<?xml version="1.0" encoding="UTF-8"?>
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<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZ52</accession>
    <name>A0A367KZ52_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_4524</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000028">
        <property type="protein sequence ID" value="RCI07450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367KZ52"/>
    <dbReference type="OrthoDB" id="5330228at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052583">
        <property type="entry name" value="ATP-helicase/E3_Ub-Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059033">
        <property type="entry name" value="C144_05_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26021">
        <property type="entry name" value="Ferritin_C144_05"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="299"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="1060"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="701"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="903"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1114"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="701"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1124"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1155"/>
            <end position="1166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI07450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1356" mass="151910" checksum="D5141E6303F04B9C" modified="2018-11-07" version="1">MTKDAIPTWIVDYFLALPTSDAVHAPSARPAKRRKIETDDSISVAPISVGKGQLSFFRSCQELADAPTVKTIRDVGSHLDFHLRDNTFSIRSRFASALGSFSVAIALKAEDASDDARKILQLEHDSVLHSSPRPLSVVFEMRIERQETAISVNVSLELLWKETSSPQLPLGSLSDGKIRQKVIDAFFPLPHTSIDGSPPSPQDFYSAAYIPPEDDAVSQHIQVSGLESPLFPYQKRSLKWLLTREGVQWSCQGSRLEPVPEDAAKPSIDIFRAVQDTSGRDVFVSDVFRVVSRDPSLFAKADSMVKGGILAEEMGLGKTLEILGLILVHRRPDTPAPFASGLRPSRATLIVTPGALRQQWMSEISRHAPSLRVTYYRGCKYSQDDDEEETVKQLAQHDIVITTYAVLSTELHFALEPPQRPRRYDRAYPRAMSPLVKIMWWRLCLDEAQMIENGYSQAASVARTIPRVNAWGITGTPIKNDVKDLLGLLLFLEYQPFCHAPHVWTTLVERHQRIFRQLFHSIALRHTKEMVQDEIMLPPQNRYVIRVPFTAVEEQHYRSLFKDMAEACDVDLDGQPLVEGWDAAQYVEVMRTWLNRLRQAALHPEIGAYNRQVLGFVKTGNRRGKPIRTVEEVLEAMLEQSEAAVRNEERAYLSSRLNLGQLYENGPRVEEALALWEDVRKETETLVADAQGKFRDVVNAKAADGDDKPDSELEDGENKGQVGEYRRRLRLALEIHHRAVFFCANAYFQMREKAKDGTEAAERLKELEDEGYQSAKAIRREMLSGSHDKAGRLMDKISRQMVTQIPDLEVLEPDRDAETGPVMNRVRVLYGELNEQAKVMDGWRSELVKQLLQPLVDEDDDMEKTGEELGDSATSQDLLLVYYQVLRAAIADRLDAISGQSNELVRHETRTSKRLAQHGDGPAPKSMLALLQERDRIKPKQSKTSMRGAISELRGMRGCQLTMTKTQTQLLEQNKVALALEAEAETFMAAMNARLEYYRQLQAVSDAVLPYEGPRTEEVEHQMKTTGLESRRRLAMTQAKHRYLQNLESSRDVGNEDQTCIICRQAATKGVLTSCGHEFCRPCMKLWFRARRNCPVCQRPLQCSDLHDVTLKPNPRTEAPLPPSSSSSASASVPATSAPTRSLPSSSANDDDDPSERAANEKETFSEPRANLVSAIQSISLGPGPSYPTKIATLVRHILFLRETDPGAKSLIFSQYSEFLSQLSQALGRYHINHGSPLSATSSSDPSVEVFLLHARAHASGLNLVSASHVFLSEPLLSPALEMQAVARVHRIGQRHQSTVWLYLVSGTVEEAIHQRRRRFGAADDVSSLVKVDKSAGELVPAEALWDCLFGCRSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZK7</accession>
    <name>A0A367KZK7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_4503</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000030">
        <property type="protein sequence ID" value="RCI07412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZK7"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI07412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="93" mass="10756" checksum="4385DF8A7672F58C" modified="2018-11-07" version="1">MTARDELPTGIQYEFCRFISIRSSYETMEYLKVKVTEVDANSFNTNNKQVPGKTDPEHAAMIANSPILNMVYHQKLERAIKHLEEKYGAYVIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZN0</accession>
    <name>A0A367KZN0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxymuconolactone decarboxylase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_1670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000026">
        <property type="protein sequence ID" value="RCI07628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZN0"/>
    <dbReference type="STRING" id="1330021.A0A367KZN0"/>
    <dbReference type="OrthoDB" id="2567457at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34846">
        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34846:SF11">
        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI07628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="22790" checksum="A69D5D1D69BFC7E7" modified="2018-11-07" version="1">MSSRFPFSEAPVSGTKELIEQALFAIHGSPPPFQWMEVDGKSMLGSHDARDLRSYTPTFVNQFFTLAKTVYDNSVVKPRNRELAILGLTSVLDVPFVVYSHREVAAKVGLTGQQYEEGRRGKVPSGLSEEEAVAYRLGQILPALKGPLDDATWQEASSKMNKAEIVGVLHTVAGYRWVAMLEQVNGLIGMLGYNVDIPAVRTNHAVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZT4</accession>
    <name>A0A367KZT4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC1 atypical kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_4519</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000028">
        <property type="protein sequence ID" value="RCI07482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZT4"/>
    <dbReference type="STRING" id="1330021.A0A367KZT4"/>
    <dbReference type="OrthoDB" id="201153at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13970">
        <property type="entry name" value="ABC1_ADCK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034646">
        <property type="entry name" value="ADCK3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051409">
        <property type="entry name" value="Atypical_kinase_ADCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019148">
        <property type="entry name" value="Nuclear_protein_DGCR14_ESS-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851:SF3">
        <property type="entry name" value="COENZYME Q8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09751">
        <property type="entry name" value="Es2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="6">
        <location>
            <begin position="721"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="259"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="358"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="486"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="546"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="494"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI07482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1075" mass="119627" checksum="FA52E7745AAEC83A" modified="2018-11-07" version="1">MEPTPKSLVRRRSDSDLMPPPPPAKKVKRPKHVLNEDDYTSTLSQIISRDFFPGIKVAAVQHEYLDAVESRNSAWISSAGRRLHDAMTPGRWRAQSLAKRLHDGGRTPPAFSGDTPSTAAATVDERPLPGSDLRLSEFQAKYTSEDNESFYKLLDKQNQKKTEKYAWMWNKNKLPSKQRLKQEEVKLRLSKTRPLVDDGFKRDRLAIKDSDDRPAQPDTWKFEPRNGLMFEPEGLEEGVVTVAQRAEDASRMPPKTIVYENTGIPEPHAPKQPPSPTMSSIRDAIAGRPRPQDRSSSDAGVGETPGLNGYTFVGEDDGETVMPESPPPINLGPGDAYNPFKLQQLRKRESLHERLVDRIAKTNKESSRRGLGRRSELQQVPKFPSSPRNSGDFTPAAQRLLSKMGTPKSKTPGSPFDRPATPAKRRDDASLDVLGAYPVLMRFVDLAIDLAAVLNASRSVAYKHVALRRRQIDAYRKISRAEAKPTELTGFDGSEERKGDSHFAKSSFATASKQSERDIKDLNKQLDAPVDVNVFHTARGSRILGSIRKGDARDVKSPQPGASAKEHPMRHWPQRPPVEFNNVSISSASDAVDESQVVEPESESSPPADKETVQVLAQAVAVQSPTQAYKLRESRVPASRFSRLWNYGGLAAGMLGGAMTESVSRAFGGGGQGSVMLSGKNMERLVTKLSRMRGAALKLGQMISLQDAKVLPSSIQEVLQRVQDKADYMPSWQRDRVLVDNLGADWQDLFLEFEETPMAAASIGQVHKAVLKSSGKTVAVKIQFPGVAASIDSDLDNLGLLLKATKLLPKGLYLDKTIDNARVELGWECDYEREAQCAKRYKELLRGDDAFLAPGIHPEASGKRVLTMDFMDGIAVTQVQSLTQEQRDWVGTQIMRLCLREITEFRFMQTDPNWTNFLFNSQRNKLELLDFGASRDYPEAFVRHYVQLLEAASRGDREGVRDLSQRLGYLTGHESKVMVDAHVDSVLTLAEPFGVSAPRAYNFKDQTITDRVRSFIPVMLRERLSPPPEETYSLHRKLSGAFLLCARLGSRVRCRDMFVEAVDKSGYVGGNGRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L024</accession>
    <name>A0A367L024_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000024">
        <property type="protein sequence ID" value="RCI07793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L024"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI07793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="92" mass="10346" checksum="5CBD5B5841D2EE04" modified="2018-11-07" version="1">MGVLQVGTLKYLEKIISISFSHLLNTNTSPASNSSSIASFRLLRDSSSSSLLPRVQLSDSGYLYTFNLFFTAFLFTFRPTNYLIRTLFSDAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L079</accession>
    <name>A0A367L079_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5771</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000023">
        <property type="protein sequence ID" value="RCI07826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L079"/>
    <dbReference type="OrthoDB" id="5402392at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI07826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="494" mass="54830" checksum="37D7F0902EC7DC82" modified="2018-11-07" version="1">MAVSEEELISTIQADLERFIKPREQVNYMRRILTLHLETYAEGPAVPPLALNDCKRLCDVGNELKGVYREYVEALQANSAARRDFEAELDAARHDYDDDSRTESISHDSDLLDSHLALMKLRQKQDCLSTIQRALKRLSEKAAFMQDLLDSEQVKQAAPALPEVPRSVVDDIAAEQSTIQPDLPSRIHQVDKALLRARLLLKKEKRLLSESRARLRDSNEPFGNDAKLEALSATRGELIAWIEAELSKASAQDPEGLTVDSERRRQPANRQTVITAQLKAISQKYATYVAARREVLELACTRWQPSMSPPQQRTAQSTQLDVHPTPVDHLLTPHVEALLSIARQQKSMVAHKSHSSSTMNKQTKAVCQALDRLAEESQLLPSHPMKGPLPQIAGVSNDVFGSSGQPQVATRAMPWVVAADSAKISTLEAVAEAIEGGQVALEGCMRSLQDIDHLLSRGLQDKKHSDTEISRQQAVDPWSFLHGNLDSIDGEPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0H1</accession>
    <name>A0A367L0H1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_5889</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000023">
        <property type="protein sequence ID" value="RCI07914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0H1"/>
    <dbReference type="STRING" id="1330021.A0A367L0H1"/>
    <dbReference type="OrthoDB" id="29879at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000008">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000014">
        <property type="entry name" value="CorA family metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF51">
        <property type="entry name" value="MANGANESE RESISTANCE PROTEIN MNR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="764"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="800"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="157"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="243"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="402"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="469"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI07914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="828" mass="92722" checksum="EB79A808ECC18978" modified="2018-11-07" version="1">MSMSGATNPASSSSAAAPSAPTAFATADDDSPKPRTVRKRKGHRGGKKKRSRRKSFAALTEDSHDDMHSSPADAFYQMPASNLSGVSIDSEALLDHREHRSMRLRRSSTTAAAAAAASSSLHNLYATPAANRHRAMHSSHSDNDDTAGRDEAIPLLSETARLRGSPVGPSSYGAAGGRTRSRRASSRSSRTKLAGLSAMKDSYHVNHPPSVPGSPTFGAADHPEMVFGDVMIRDELSLPSGSPRFSLDGDANLSATDGPVRDHRTDHGRRLTASGPGDVCFPVRGMSELGEEDAQSRDPELHQYRARRRRGQWPDLSTLEEWKRFEKEEHSDETRVKKITEPQLINGRLRPVRKGWYQADDEIPYRFTYFNEEFQSTIHSPTISELVQPGSDFRELFIPDPRVLSDDETDDEGETLSPQLRPSATARGGDGDSRTPTQQAFHPDIRRQDFARDVVTPASDRATPVSSRSPEHEAGRDKAHTGDRESASTTKPIRYGERPVWWLDVLCPTEAEMKVIAKAFGIHPLTAEDIMVQEAREKVELFRHYYFVNYRTFDQDLNSGNDLEPVNMYVVVFREGVLSFHFSMTPHPANVRRRIRQLRDYLILSSDWISYAIIDDITDVFQPLIQNIEAEVDEIDGEILQLHSSADKRIKDQKNSVDDNNTAIVDSSDMLRRVGDCRKRVMSLYRLLGNKADVIKGFAKRCNERWEVAPRSEIGLYLGDIQDHIVTMTSNLGHYEKILARTHANYLAQINIRMNERQEQTADVLGRLTVLGTIVLPMNIITGLWGMNVWVPGQQYEGDLAWFVWITVGLICFGLACYLIAKRVYKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L158</accession>
    <name>A0A367L158_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_6261</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367L158"/>
    <dbReference type="OrthoDB" id="3647690at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038609">
        <property type="entry name" value="HDA1_su2/3_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="4">
        <location>
            <begin position="57"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="108"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="194"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="397"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="480"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="583"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="753"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1100"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1137"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1423"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1222"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="199"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="230"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="333"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="428"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="491"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="607"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="638"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="784"/>
            <end position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI08170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1500" mass="163338" checksum="4A5328897A183E22" modified="2018-11-07" version="1">MPTKPSSAGSVSALRSASRASRRSVASVAGQRASHHLMKPRAKTPKTTTNKAKNEWYSIRGILRERKAKGRVEYLVDWEDDGVTGQRHDPTWTPSCDVTDAARRDWEANKAVQKKQPGDESKPPKRKRANAGHQGAEGRPHKVPKLSHSATPSEEPVFPLKADHQSLTPQAASAPTLRRLRTLVVEIAQTPLFDPSGFVSYSDSELTGAAPSQSLPKVEDDGDGDDNQTETKSVVATRESGQTIPDSQEPSGQTGLSAARSLATPRQGPSPSPDSHLADPETRQSSSPAAENRPHQLASPHRQSIDQESLPDYETPAPEARDPTELAASPSPDPERYPSRSPDYHLHQFASWSQLAYRPESPYSPLSPGAAEAAADQLSGSFESPIFASQLSPRHTFALPETSSSGNLIPATQTDSATQTDGVFFAYEQDEEEDVEQDDQTDVSIKSEDQDDEYSFVDFERAGHHSLGYYADNVLPSVESDDFVDATGNQEPHDSGAESTDAHHGSRGAGSSDYSTESPDRPVEEVNCDSPDYRPDDFEFGSAEYQPEPVAVAFPEEEEDFVSEDESLEREFAQIIARRRQAEAEAEAEAEAAAALSTDAQVDHASQHGQVDNGSQRAQFDHASQDAQVVAREHLRSQRSTFSTDSGTGHMSPAIPIPPPAAPAAPDTSSMADESQDPPPANQELGTHQEQEARCAIPPAPRKESERIIQNRQRVMQNVQNLMKLHSGPSAPPIKPSPIGTKVQNMFKDRFPNTPSRPMVASSAQDATVSPADISKPLPEPTPATWTSNTIGSSSSQATPQMGQGLPEQSSSHDSADAVIEPCQGEHVITLPFQASQRPYYDESLVKSKRVVNELNTIFSNEVWVEPTDSLVHQVDELLALLFNACDFPPDIVASLADLPASQKAKYSCDANAKFNFVFELLQGARKDTKILIIARSVALLRLLSHLTEVLELDCACEAIGQSATSAARVTLALPSDDMNGTNFDVIIGFDHSYPTWRASSSLLSSAAKKPLTLHLVTTHSIEHISLHVPANLGPVEHKNALLSSVVRARQLISDPERGYLEPHEIAGKFVAYINNTASAIAYEPVPLPDDVAHIFRTQGDEEISDSSSSPTDGDGRKRKHVRLQCRPCGHDELTVEIQDGTAENAEGETAGDARAKRPRLLPNHGANQPPLPDEVQSLLRKMGVATDTSSGRPGDVQVNVTLSSLQTLAEKFAENERRATANDAEAEYKAVISRLEKQVKEYERSMDQIYKSNRKALEDRSRFEDEKLKAEAALEDEKSRAEAALGRKETKIAELEAVVERLTSNPNGNEETPLAKTNRLLEEANGKEKQLQKRLQNAQQDMNYVKDRYQEASTSAAAAQEENSKLRAQTDILKRKASENVVKVHRMQLESDTRVLAQEASGLRAQLKERDWEMERLREEVRKNGRRETRQASLPRSPHAAGIMSPHLQARANGVGSGSRGTSPSVGTGHLDGAGGAPSGAQFTGGQPGGNGRWSHLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1B6</accession>
    <name>A0A367L1B6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Triosephosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_6320</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:18585"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="5.3.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.1" evidence="4"/>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1B6"/>
    <dbReference type="STRING" id="1330021.A0A367L1B6"/>
    <dbReference type="OrthoDB" id="6715177at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00189"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004807">
        <property type="term" value="F:triose-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046166">
        <property type="term" value="P:glyceraldehyde-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00311">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035990">
        <property type="entry name" value="TIM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000652">
        <property type="entry name" value="Triosephosphate_isomerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21139:SF2">
        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00121">
        <property type="entry name" value="TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51351">
        <property type="entry name" value="Triosephosphate isomerase (TIM)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51440">
        <property type="entry name" value="TIM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="4" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI08230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="253" mass="26926" checksum="E035E14A771013C2" modified="2018-11-07" version="1">MSSRRLVGLSTKMYFSLSQTRHFVDPLVELLPPPTAKDVSQVDIFLIPDFVSLAETAARLETTPLWTGAQDCSWEDEGALTGEVSATVLREAGARIVMVGHAERRRLMAEDDSIVARKAAAISRNGMVPLICIGETTAGAGTVAAVAECRPQIEAAVGAVSAETDVVLAYEPVWAIGADRPAGDDHVRAVVDGIRRLDCVAGRRQGSVRIVYGGSAGPGLFARLGGSLDGLFIGRFGHDPEQFVRTIREVVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2K5</accession>
    <name>A0A367L2K5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_4876</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2K5"/>
    <dbReference type="STRING" id="1330021.A0A367L2K5"/>
    <dbReference type="OrthoDB" id="4682787at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF96">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="38"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="292"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="475"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="478"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="501"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI08637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="527" mass="58130" checksum="1519DB974352B884" modified="2018-11-07" version="1">MDLSDFVKPNVDLSRSNAPGLVVVCALFLPLTWLAVGLRTYARGYMTRNFQIDDWLMLVALVTFTLTCCFVLAGVGRGLGKHNAALSIPDLVAALMWQSIATSIYILNMMFVKLSIGIFLLRLTNVWAIYKWILWISLTIVTLWSIGLFIWDIFQCTPVQKQWDFRIERGQCASPKGIVDSVIALTVLTVSSDWLYALLPIPMVWNVKMTLQAKATVIVILGLGIFASVATLVRLKFLNGLKQLDDLSYTASDTLIWSIIEPGVAIFASSMATIRPLLRFCKIKGFTTQFTKSRPGEEKTQAKEYPNEDDEGKKTGGPGAPALNISEISLNSPGVAVLTNDVGQGGHPNFANKNNSDMTPLEACKKRAQERKNSTMKGDWAAYGISGTLSFESLDYEEEEDGEEIEIGRTATANYGSLSLENFDSMRAGPLVPTDSRPLSDARSDTFVIEDHRRTSTWQHPALLTSVLAGDVDLEAQSPDKGKGRDFDGEHCDDDGHGHDDEYDDGDDVEEDTDDDELLSSYPGRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2Q6</accession>
    <name>A0A367L2Q6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CTLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_4839</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2Q6"/>
    <dbReference type="STRING" id="1330021.A0A367L2Q6"/>
    <dbReference type="OrthoDB" id="972532at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051350">
        <property type="entry name" value="WD_repeat-ST_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838">
        <property type="entry name" value="WD REPEAT PROTEIN 26-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22838:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23627">
        <property type="entry name" value="LisH_WDR26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CTLH" evidence="6">
        <location>
            <begin position="228"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="454"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="665"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="59"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="158"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI08706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="724" mass="78232" checksum="FD9BA3E6B869EDFE" modified="2018-11-07" version="1">MNFPPSPNPTAVPGRGEVDVERPSDPRGPIDDPAASHSSSNAASSARTPTATLEDDQRASSGATAFANIENSTARALPTSSPPPQVLGRRRRSLGPQSPPASAVRPTAAAVSPILPPSKRRRRDGAAMPADADTSGHPNGHLASRSNGSTAQHAGVTNGAQKSAVATNGSSSSTGEKHNQPGDAEPQPSTYFGHDREELTRILIQALSDMGYQAAAESVSRDSGFDLESPTVAAFRSAVLDGSWVEAEKLLSGAGMSDGRGGGNGLVLAATSDRNVMKFWLRQQKFLELLEQRDTSRALTVLRTELTPLYQDTGKLHFLSSLLMCRSAEDLMNKANWDGAGGQSRRQLLSQLSRCISPSVMLPEHRLAVLLEQVKQRQIDTCLYHTAASPPSLYSDHYCDKRNFPSEVAIVLADLVGEAWQVRFSNDGSKLAAGGDRENVMIWETKTFTLVNALSGHGDGVGNLAWSPDDRLIVTCSQDKIARLWDTKTGTLRKVIRTFSEPVSGCVWSADSLSFVLGTLDKTHSLCSFNVEDDGCIEWDKKHRVQDLCGSLDGKWLVAADDLTKIYVYKAATRELEYHLDVGTRPTSVSMSQDCRHLLVNKDGEAQLIDLETRQSAQKFLGHLGGAFMIRSALGGANESFVASGSENGYVFIWHKNIGVTVERLAGHLPRCNSVCWNPMDPCMLASCGDDGQVKIWTNKARMMELRSTHPKPSNGWRGSISEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2Y0</accession>
    <name>A0A367L2Y0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">H/ACA ribonucleoprotein complex subunit CBF5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Centromere-binding factor 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">H/ACA ribonucleoprotein complex subunit cbf5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">H/ACA snoRNP protein CBF5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Small nucleolar RNP protein CBF5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L249_4788</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs and play a central role in ribosomal RNA processing. The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs. Catalyzes pseudouridylation at position 93 in U2 snRNA. Also catalyzes pseudouridylation of mRNAs; H/ACA-type snoRNAs probably guide pseudouridylation of mRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a uridine in mRNA = a pseudouridine in mRNA</text>
            <dbReference type="Rhea" id="RHEA:56644"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:14659"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>uridine in 5S rRNA = pseudouridine in 5S rRNA</text>
            <dbReference type="Rhea" id="RHEA:47036"/>
            <dbReference type="Rhea" id="RHEA-COMP:11730"/>
            <dbReference type="Rhea" id="RHEA-COMP:11731"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>uridine in snRNA = pseudouridine in snRNA</text>
            <dbReference type="Rhea" id="RHEA:51124"/>
            <dbReference type="Rhea" id="RHEA-COMP:12891"/>
            <dbReference type="Rhea" id="RHEA-COMP:12892"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2Y0"/>
    <dbReference type="STRING" id="1330021.A0A367L2Y0"/>
    <dbReference type="OrthoDB" id="10250002at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000495">
        <property type="term" value="P:box H/ACA sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02572">
        <property type="entry name" value="PseudoU_synth_hDyskerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21148">
        <property type="entry name" value="PUA_Cbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.10:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012960">
        <property type="entry name" value="Dyskerin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004802">
        <property type="entry name" value="tRNA_PsdUridine_synth_B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00425">
        <property type="entry name" value="CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003280">
        <property type="entry name" value="PRK04270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127">
        <property type="entry name" value="CENTROMERE/MICROTUBULE BINDING PROTEIN CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT DKC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08068">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01136">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dyskerin-like" evidence="14">
        <location>
            <begin position="23"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="PUA" evidence="13">
        <location>
            <begin position="291"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="428"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="428"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="470"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="481"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00056777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00072225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00077661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00081789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00082909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCI08791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="511" mass="56468" checksum="19A820B616DDDEC3" modified="2018-11-07" version="1">MDLVKKKEEDYAIKPQAVTPPLDTSSWPLLLKNYDRLALRPLVPCPAYQTRIVKVLVRTGHFTPIPNGCSPLKRDIKSYISSGVINLDKPSNPSSHEVVAWVKRILRVEKTGHSGTLDPKVTGCLIVCIDRATRLVKSQQGAGKEYVCVIRLHDKVPGGEPQFARALETLTGALFQRPPLISAVKRQLRIRTIHESRLIEFDNDRHLGVFWVSCEAGTYIRTLCVHLGLLLGVGAHMQELRRVRSGAMDESKQLVTLHDVLDAQWTMDNTRDESYLRKVISPLETLLTSYKRLVVKDSAVNAVCYGAKLMLPGLLRYEVGIEHHDEVVLMTTKGEAIALGIAHMATVEMSTCDHGVVARVKRCIMERDLYPRRWGLGPVALEKKKLKADGKLDKYGRPNDATPATWKTEYKDFSTDDAVAAAAAAAPSSSATASMPQPPSSTAVTTTTTAMDTDQPPPADEAESKKRKKHEGETPEEKAERKRRKAEKKAAKAAKKSTKKEAGAADDEDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L322</accession>
    <name>A0A367L322_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_4824</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L322"/>
    <dbReference type="STRING" id="1330021.A0A367L322"/>
    <dbReference type="OrthoDB" id="38531at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057688">
        <property type="entry name" value="DUF7928"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408:SF2">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25550">
        <property type="entry name" value="DUF7928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="720"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="752"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="847"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="877"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7928" evidence="4">
        <location>
            <begin position="52"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="3">
        <location>
            <begin position="523"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI08826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="904" mass="100938" checksum="1D55D97A1C512246" modified="2018-11-07" version="1">MDSPPSSPAPGRAPLSRKTSYVEASEETSSQSNALQTRPSTPSNGTYDDVFRYRTMVSYLYNRVVASGWIPSTCNDDDCLGVMLRRSRGTYVASPDPAHPLLVGAIIRLNLAVAVTMRPQMLDGILRSLSPGQTELRFKGGSQIQIVDSLATVRAATVKKFQYAAICLHERLVLVWQDDLQHIIPTAMQIEERLLSLVWGEGKLPFNMLQLPSRAPSSLSSGISSPNGTSTPALEKAGPRLHVNESSEELTDDPSFDRLESLSRPVARASAVFIGLAMVTAISLIFGVYSGQLFTESLLDHSYSRLGLIAFCPLLLCISLFFFQVVFTNLFQLMGPIGGVSTNSRYYSCHKPCLRRAYADGFVPPKITIQMPVYKEGMDSVIVPTVRSLQAAVSYYESHGGTANILINDDGLRAGISPEEIQKRRDFYHDNNIGWVARPKHNGPERFVRKGKFKKASNMNFALNTSQKVEAYLQDMVDARVAAGGSDLIDESDEADMYKEALSRVLDENPLAWAEGDIRLGEIILIVDSDTRVPVNCLLYGAAEMYLSQEVAIVQHSTGVLQVSRDYFENGITYFTNLVYTSIRFSIGSGEVAPFVGHNAFIRWQAVQDISREDTGGYTAYWSEAHVSEDFDMALRLQIKGNVIRIATYHNNEFKEGVSLTIYDEISRWKRYGYGVSELIFHPLHRWILKGPFTPLFYTYLGSNIMLSSKISIMSYMCSYYALGAALPLSVMNYFIVGWFRDNLASCYLTSWNVFLSLVVIFNASSPVALAVLRYRTGERSLLGALVENAKWMPMMTVFFGGISYHISTALLSHLLHIDMEWGATAKEKEDSNFFQEMPRIFRTFKYMYLIVFLLAAGIIYLSVWAPPDWAITDFSVIIPVSINLAFHALAPLVLNPSLMIFNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L369</accession>
    <name>A0A367L369_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Leukotriene A(4) hydrolase</fullName>
            <shortName evidence="14">LTA-4 hydrolase</shortName>
            <ecNumber evidence="14">3.3.2.10</ecNumber>
            <ecNumber evidence="14">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L249_5087</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>an epoxide + H2O = an ethanediol</text>
            <dbReference type="Rhea" id="RHEA:19037"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:32955"/>
            <dbReference type="ChEBI" id="CHEBI:140594"/>
            <dbReference type="EC" id="3.3.2.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13 14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.3.2.10" evidence="14"/>
    <dbReference type="EC" id="3.4.11.-" evidence="14"/>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI08881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L369"/>
    <dbReference type="STRING" id="1330021.A0A367L369"/>
    <dbReference type="OrthoDB" id="79562at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09599">
        <property type="entry name" value="M1_LTA4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000009">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.320:FF:000001">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000004">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.30:FF:000001">
        <property type="entry name" value="Leukotriene A(4) hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.320">
        <property type="entry name" value="Peptidase M1, leukotriene A4 hydrolase/aminopeptidase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012777">
        <property type="entry name" value="LTA4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049980">
        <property type="entry name" value="LTA4H_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038502">
        <property type="entry name" value="M1_LTA-4_hydro/amino_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034015">
        <property type="entry name" value="M1_LTA4H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015211">
        <property type="entry name" value="Peptidase_M1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02411">
        <property type="entry name" value="leuko_A4_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45726:SF3">
        <property type="entry name" value="LEUKOTRIENE A-4 HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09127">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01263">
        <property type="entry name" value="Leuk-A4-hydro_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 14" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M1 leukotriene A4 hydrolase/aminopeptidase C-terminal" evidence="16">
        <location>
            <begin position="501"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="418"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="171"/>
            <end position="173"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="301"/>
            <end position="306"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="597"/>
            <end position="599"/>
        </location>
        <ligand>
            <name>a peptide</name>
            <dbReference type="ChEBI" id="CHEBI:60466"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR612777-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR612777-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR612777-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCI08881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="643" mass="72620" checksum="91E88355F7A7031D" modified="2018-11-07" version="1">MSSRSLLRGGCRPRSLPTPAGSHPSLVRASAAPRLFTMAHRDPTTVSNYEAWRTRHTTVQFALDFDAKRLRGSVLLRLQSQTDRKSTEVILDTRFLTISSVRVDAAPAEWELKPHSHPLGAPLHIAVPDGASKGDSVDVHIDLETTERCTALQWLTPAQTSSKKYPYVFSQCQAINARSIFPCQDTPDVKSTYTFKLTSILPVVASGVAVSPDAASPGVETVYQFEQPVPIPSYLFALASGDIVTAPIGPRSVVATGPNELADCKWELEEDMEKFMDVAEKLVFPYKWGEYNVLVLPPSFPYGGMENPIYTFATPTIISGDRQNVDVIAHELSHSWSGNLVTNSSWEHFWLNEGWTVYLERRILGEMHGKAHFDFSAIIGWKGLEDAIEMFGRDHEYTKLVISHNNVDPEDVYSQVAYEKGFHFLYELERLVGRQNFDKFIPHYFTKWSEKSLDSFEFRDTFAQFFKDVGDEEVTKKVDAIDWEAKFFTPGLPPKPDFDTSMVAACYDLANKWGDDSFEPKAKDVEELTANQKLVFLDKVQQAAPLSPERAQLLGKVYEFITTKNAELKTAYYLVALKARDPTCVYGVAELLGAVGRMKFVRPLFRELNRFERQFALDTFARNKDFYHPICRGLVEKDLGIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3U0</accession>
    <name>A0A367L3U0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_5061</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI09090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3U0"/>
    <dbReference type="STRING" id="1330021.A0A367L3U0"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391:SF3">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="395"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="423"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="61"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI09090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="548" mass="60395" checksum="97723D972C21F827" modified="2018-11-07" version="1" fragment="single">MDPWVPRGTFQQPHQPVAAPSFTPYPQTLIDYRTVCSSSDCATLPGDSGYGSIRQSFSIASASVHGGDDLSQPYLEPHSPPPPPPPPPPPPSSLDSPSKPVRGHVCDECKASLKSQGELKQGSFSLCFSKHKQRHLKSHKCPYSKCLKGQRGFSTANDLVRHKRSVHGEHDLPGKSFVCPYCIPGSKGPKVWPRADNFRSHLHRSHHVELKPDDDHKQYLYRPKNDLEGVGGSLASPASSQTPSGVVRLPVQHDAHFSAMPAMDDQQHLLCAGDDTMASSVHDPLLAISLENFMAEPDLSQPSSSSSPWPFSCGDDSHLSPTPMPTLPNWIPNEAGTGLCEFAAGPLSVGDATASAPLPSSDPSEIVKYLRTFPKPCLQTALRGSSGPSDDDSGWKCAEQDCGKTFNRPCELKKHMKRHEKPYGCTFRDCPKRFGSKNDWKRHEGSQHLGLEKWDCDEPGCGRICHRRESFKNHLQKDHGMSNGGSMDEKLESCRMGRPCDPRFWCGFCVKIMEMEDVGGNSWTKRCDHIDSHLFGKEGLTKKTMGEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3V7</accession>
    <name>A0A367L3V7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_5063</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI09088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3V7"/>
    <dbReference type="STRING" id="1330021.A0A367L3V7"/>
    <dbReference type="OrthoDB" id="899at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000003">
        <property type="entry name" value="membrane-associated progesterone receptor component 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF115">
        <property type="entry name" value="BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="3">
        <location>
            <begin position="21"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI09088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="121" mass="13184" checksum="58039A26DE58DC73" modified="2018-11-07" version="1">MAPRFEPKVPVQLDPPKDDPIPTEQLAKATGVDGSTCYVAIKGKVYDVTGNKAYQPGGSYHVFAGKDASRALAKSSTKAEDVSAEWRDLDDKEKTVLDDWITFFSKRYNVVGVVEGATNSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3Z0</accession>
    <name>A0A367L3Z0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_1565</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3Z0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016867526" evidence="2">
        <location>
            <begin position="31"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI09146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="285" mass="31166" checksum="3BC5E912B3544186" modified="2018-11-07" version="1" fragment="single">PLLLHPLHRPSQTAIIYLLLLLLLIRWSRPTPSRHEHRVPAFTPVPAKAIATCRTRARSFAPSRKQTGSGRRSHNTLLHPTSTGSLPPSTAFPAQPCNNNKTPVRRVPPLPSTLIPNATPTTICNSPPTAPGQRARSGSSGRPSNTPSAIRARTFAPRSSAPLTSGCRCRLRAYRSSPRLLACYTNRRCSSTMFRTRPSYAVAFPSLIASSVLLRRSMLLITSASSPYASYSSLIARAPSPSLPTSSSTFSAARVWIYSGVIPLHVPPRTTTWRWSPIRRVAYFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4P5</accession>
    <name>A0A367L4P5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_3703</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000015">
        <property type="protein sequence ID" value="RCI09378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4P5"/>
    <dbReference type="OrthoDB" id="4927827at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI09378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="77" mass="8346" checksum="9F2CFFB8D71260C0" modified="2018-11-07" version="1">MRYLVSIKALGLTLGDACNLKDLKLRVYADASFANDLYIRCSTASYVVFIGLSPTIVTLSSIEAEFINLTPTGISII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4Q4</accession>
    <name>A0A367L4Q4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_3643</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000015">
        <property type="protein sequence ID" value="RCI09400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4Q4"/>
    <dbReference type="STRING" id="1330021.A0A367L4Q4"/>
    <dbReference type="OrthoDB" id="207120at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11887">
        <property type="entry name" value="SH3_Bbc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057402">
        <property type="entry name" value="AIM3_BBC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035552">
        <property type="entry name" value="Mti1_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46026">
        <property type="entry name" value="RHO-TYPE GUANINE NUCLEOTIDE EXCHANGE FACTOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46026:SF1">
        <property type="entry name" value="RHO-TYPE GUANINE NUCLEOTIDE EXCHANGE FACTOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25459">
        <property type="entry name" value="AIM3_BBC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="2"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="59"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="153"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="210"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="230"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="289"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="382"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="404"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="420"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="463"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="535"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="554"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="572"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="588"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="684"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="704"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="744"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="767"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="799"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="814"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI09400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1162" mass="122998" checksum="68C541566293A4C5" modified="2018-11-07" version="1">MVAPFRVKAVYEYSSPHEDDLNFPIGQIITVTEEEDDDWYGGEYVDGAGAKHEGIFPRNFVEKYEPTAPPRPVRARPKKDSEAASQQQQQQQQQQQYSPEDAAFSPTAGPSQAAAQAEPPVLPKQESPEAVETVEPASTRSPVESPTAREAPPKASDPAAGPASPAIPSSPAPKAKPAAPAPSAEKPSSNSFKDRIAAFNKPAAPPVAPFKPSGLSGASGSAGFIKKPFVAPPPSRNAYVPPPRDTPSAPIYKREEDAESKERVPASPEQADKPRAVATGSSQDGGDEEQPKPTSLKERIALLQKQQMDQAQRHADAAAKKEKPKKPPKKRAEQDITTGDAAADVPPPAVTSPRELDEAGTRTSTDEAAPARVPPTPRRKSSKEPAAEPVHDGNDADMSGAGDTTEDHDDSTEREDSDGASLRAARRPSTAATPPGKNEDDSEDEPEGEGEEAEEEEEEEVDPEVKRKEELRARMAKMSGGMGFHGMFGAPMPPSAASGLKKKASRPETTSAGDEATSPVSRAAPPIPTLMALPGMGGGGGGGGGAKASEETASPRVASAPSVPARAVEAAPKVDKSKDAEKGKDNKEEEEVKEEEEEEEEEEEAKTPAALPDPKSNRRGTGGRSAPPPPVQLEGRSARDIKSATEGSESDDELSGAGTAARSPPAATVQSPAQPTRSPPMSPPAAGYSPASPPGASQKRMSRAPPPVPGSAPTLPPASTRPPPPPLPATMDGSAMPPRPAVAGDEENEENTEYEGDYDTDIASSVPHKDALKSHARDSSVDEKAPLSPTTDARSAPRGVPPPIPSQPPPPQEGSKRRSMEAVREDDDGPSQTSPSSGRHPYLPAAKMEDVMRGGPAAPPPDRKLPSLPGSSGVGGRGVGRPSMDASRPSIGGRASVDMNRNTSTEGFIASDLDLSAHSGWWRQPMAVPPALQGRRDVLYESDESATTNQGSKTVVTRAIYVLFQDYSQTVVTARFDPYRAADGVELEQNHEGPPRPLRQDQMEEFHERYGVKLLAAAAAAKDTVVGDGTAQGLITELLRPHRGALAPVGTRSYGALVYANMANASTQQHDVIRPGDIMSTRNARFQGKHGPMHAKYSMDVGKPDHVAVVAEWDGTKKKVKAWEQGRESKKVKLESFRLDDLRSGEVKIWRVVPRSWVGWSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4Y9</accession>
    <name>A0A367L4Y9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_3794</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4Y9"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI09481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="46" mass="5668" checksum="9350DC56CCC9DC3A" modified="2018-11-07" version="1" fragment="single">IDRIDTYNRDFEVSRENHQHQLFSPSQYKHLSCLQFFFNCLFQTIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L581</accession>
    <name>A0A367L581_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 15">DNA topoisomerase 2</fullName>
            <ecNumber evidence="5 15">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">L249_4122</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the type II topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="5 15"/>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367L581"/>
    <dbReference type="OrthoDB" id="276498at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
        <property type="term" value="P:sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16930">
        <property type="entry name" value="HATPase_TopII-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00187">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03481">
        <property type="entry name" value="TopoIIA_Trans_ScTopoIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03365">
        <property type="entry name" value="TOPRIM_TopoIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.40:FF:000003">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000008">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000004">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.670:FF:000001">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.199.10:FF:000002">
        <property type="entry name" value="DNA topoisomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.670">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.199.10">
        <property type="entry name" value="Topoisomerase II, domain 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.268.10">
        <property type="entry name" value="Topoisomerase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050634">
        <property type="entry name" value="DNA_Topoisomerase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001241">
        <property type="entry name" value="Topo_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013760">
        <property type="entry name" value="Topo_IIA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013758">
        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013757">
        <property type="entry name" value="Topo_IIA_A_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013759">
        <property type="entry name" value="Topo_IIA_B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013506">
        <property type="entry name" value="Topo_IIA_bsu_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002205">
        <property type="entry name" value="Topo_IIA_dom_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001154">
        <property type="entry name" value="TopoII_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018522">
        <property type="entry name" value="TopoIIA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031660">
        <property type="entry name" value="TOPRIM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034157">
        <property type="entry name" value="TOPRIM_TopoII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169:SF38">
        <property type="entry name" value="DNA TOPOISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169">
        <property type="entry name" value="DNA TOPOISOMERASE/GYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00204">
        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16898">
        <property type="entry name" value="TOPRIM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01158">
        <property type="entry name" value="TOPISMRASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00418">
        <property type="entry name" value="TPI2FAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="Type II DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52040">
        <property type="entry name" value="TOPO_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12 14 15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="13 14 15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 14 15" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="17">
        <location>
            <begin position="544"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IIA-type catalytic" evidence="18">
        <location>
            <begin position="797"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1176"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1283"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1357"/>
            <end position="1643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1176"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="1188"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1295"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1312"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1502"/>
            <end position="1518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1542"/>
            <end position="1561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="1604"/>
            <end position="1643"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="14">
        <location>
            <position position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS52040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RCI09579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1643" mass="183535" checksum="DCB265061E5EB332" modified="2018-11-07" version="1">MDSEDSAFSLDDESDGYVPQKKPKPSAAAPKKTLQTTLKAKTTAGKKRPKLDSDDEDPDDVSAGFSNTPPSSKKQKKPPPPTKKPGTAPLVEVENDSVMMDAPSKPKSSKSATETYQKLTQLEHIIKRPDTYIGSVEKTDQQMWVFNKTTSQMEYRNITFVPGFYKIFDEILVNAADNKQRDGSMTHMKVNIDRSTGEISVENNGKGIPVVIHDKEKIYIPELIFGHLLAGSNFDDDEQKTVGGRNGYGAKLCNVFSNEFTLECQDSEHGKRYKQTWTNNMQKMHKARISSSKSADFVRVTFKPDYDRFGMPEGISDDLEALLHRRVYDMAGTIRGVKVHLNGDLIKLKDFKAYCDLYAKSIAAERTMEEGGTPTCTVEMDKDKSHPRWEVGFTVSDGTFQQVSFVNSIATTSGGTHVNYVADQITASLLKALNKKQKGHSLKQSHLRNHIFIFVNCLVNNPAFTSQTKEQLTTKASQFGSRCVLGDEFLKKIAKSEAIQNIMDFAQKKADKMLSKSDGSKRSRVSNAKLVEANLAGTKRGHECTLILTEGDSAKGLAVSGRAILDPDRIGVFPLRGKLLNVRDATIDQITKNQEIQNIKQFLGLKHKQVYTDTKSLRYGHLMVMADQDHDGSHIKGLLINFLQVQFPSLLQIPEFFREFITPIVKVWQGPNPKKPLKLKSFFTQPQYQEWKESHKEELSRWQSKYYKGLGTSSNEDAQVYFTNLDEHLKEFQTMRPDEADLFDLAFSKKKADARKEWLGNFVPGTFLDHSGKSITYGDFINKELILFSMADNMRSIPSVIDGLKPGQRKVIYACFKRNLVKDKKVVELAGYVSEQTAYHHGEASLQQTIIGLAQNFVGSNNINCLEPSGNFGSRLAGGSDAASPRYTFTRLSPFAKKIFSPLDEPNLKYHYDDDKRIEPEMYAPVIPMALVNGADGIGTGWSTSIPNYHPMDIVKNLRRRMGRLDDGDSEEKPFETMIPWFRGWKGTAEAAGPDRYKFNGVAQLNERNPNEVVITELPIRMWTDDFKAKLEKVISGVDGPSWIKDYKEFNDHKTVHFEIQVDEKHVGKVVEEGLLERFKLTKQVATSNLVAFDTRGQIRKYEKVEEIMEEYYHYRFDMYTERKKYWLGVYHADYSKLTNQARFIQEIIDGVLVVGKKKKDVLIRELRERKYEPFPRGQDVKKKAPEDEISPSDDEEQDETADKGSRDYDYLLSMPIWSLTLERLEKLRAAIANKKAEHDELEAKSEKDLWCADLDAFSSEWNNQLALDAEIQTNIRRMGRRVSRKIGAGRSRKAKDDDAYEPEKKGRAKAKAAPAAVKTETKTAQRFAEMFSAKPKAKKEAAPAAAEADKFSDDDFAALSKGKAPAAKTSQARPVSQAPARTGERSKRAAASKAKTLFEVSSDSEDDDQLLGDIGAMVKGIGKPEGDASARLSLHAMSRPESSHGALSKLKTKPSKSSFEADGPDDTNYELLARSSPVKADTKKDVVDSFLSDDDDDDVISKAAPKAAAPKAAAPKADTGLAVVKKARGRPAKSKAEAKVAKTAKTAATLSPAAKAYAARKVAKKPVVSDESDLDDVMISAPPPEPVRARPGRAAAARRPVVVEDDDDDDDDDDEDSSLVVAEEEEEESDDPFEMEEDDGDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5E4</accession>
    <name>A0A367L5E4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nuclear control of ATPase protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_4161</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5E4"/>
    <dbReference type="STRING" id="1330021.A0A367L5E4"/>
    <dbReference type="OrthoDB" id="413313at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013946">
        <property type="entry name" value="NCA2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234:SF1">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08637">
        <property type="entry name" value="NCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI09637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="653" mass="73483" checksum="FBB40378F0296B03" modified="2018-11-07" version="1">MSVVSDQVRRLDAYLDRRPVLSPASSDNGAYDAVYADVDAFSAPRLDQLLRIAQALSTTSSSQPLLSAQRVRSLLLQSGLSSRPHHDAAALETPRSAYEIEIEWLVVTKATIQVYGVILNALLDRISPLSDDIWYWSEVLNSYTYSSLYTVQTSPLRLWAWTRDVYLASRARMCSDDLVQSTAAGLSTGWVRLYDIVRHSIRERSLSSIQRKVLSPVAFCRAEARRKLAQLRKLREISASGLGVLMDEGLQLGHDDEKAEQYDLKSIVERSVALMDMVLKEVCVLDVSIDDFEDKVFGGVEEDPELSVQFEEHNVTPDRPSALARRLLRIIDETLPDHAVTMQALAQANGRPPRLVRFWLPAVVGLLSSTTLLRVLTKRRADIVDWVVNFGATVRDFWLNWVVDPLQKVVRTIRHDESSEIAIMSRDSLMADRQSLERMVVDFAVDKPHFAVDGFTISDAQLADIRTKVAEGDVTPVLRAYEKDLKSPLMGALRGDLVRSLLIQVQKTKVDLEVAMTGIDSLLKSQELVFGFVGLTPGILVTMGTVQYLRGVVGGRTGQRRSTTTCRATRLLRNIHRILSEARPTENNVLSYRDHGLLLCELHELRLLAGKMLPRDVERDFSEDLDDLANIKGVHIQTRALDRIRWAYSRWLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5P4</accession>
    <name>A0A367L5P4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_4136</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5P4"/>
    <dbReference type="STRING" id="1330021.A0A367L5P4"/>
    <dbReference type="OrthoDB" id="5340910at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11854">
        <property type="entry name" value="SH3_Fus1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035521">
        <property type="entry name" value="Fus1_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="426"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="87"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="152"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="348"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="480"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="32"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="152"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="179"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="203"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="352"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="552"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI09756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="594" mass="61923" checksum="08317B7929D300AB" modified="2018-11-07" version="1">MAHKHFHRSLHDRRDVYGDARFVNMELINNDRPPPPPPAPPPLPLPANDIRVQNQANRQATEAEMRTVIETIYKTLDPTFSGPIGGYVTLSEDARPPASAAPSPASDRKLARIDSKSSDAVVARPSPTTETPSTAEATSSIEAALATLTSTLTSEDGSLSSSSKMAESSPSALSSPTLSPTPTPSPVPSPTPTATPHAAADLSRGKKAGDHGGGDKGGSPVGPKVGIAFGVIGGIVAVGLIAFFLLKRRRKQAAKGYKLEDEKSRKGFGAISNPFESSSRDNPGAPRISLRPVTQFLPNWNGLEKRTSRGPMAAAAAAAAASASAPLGSSWDRSINNPFDSVPSTIAEEQSVRSFSTSSGSISGTSNPFAGGPDAGSHHHHPSRPSGPSGSVDLSRKWGPGPSSPTGTDYSLTSVSSEMAAAGGPPVSSVHRVQLDFKPTLDDEMELRIGELIRVFHEYDDGWCLVSRLDRSQQGVVPRTCLSTRPVKPRQPQGVMPRMGPPVNPTGPGRGPNQTRAQGQGPARMGPPGGNFGRPPSPPGAQSFRSGPGPTVLNSGPPTNRQGPLKPRYRVSPPGPPPNYAPMGPVSRKPVPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5U5</accession>
    <name>A0A367L5U5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ras-like GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_4158</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5U5"/>
    <dbReference type="STRING" id="1330021.A0A367L5U5"/>
    <dbReference type="OrthoDB" id="25896at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00154">
        <property type="entry name" value="Rab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000808">
        <property type="entry name" value="Small GTP-binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24073">
        <property type="entry name" value="DRAB5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI09791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="34048" checksum="42D336800A354165" modified="2018-11-07" version="1">MSSSLEAKIVVLGAQGVGKTSLVMRYCKGAFNPAQTTSTVGASFMTKRVVDTDSDTVVRLQIWDTAGQERFRSISRLYYRGANACILCYSITDAQSFDDMGVWLTELRRNLPNDVVLHVVGTKADVVTRDPSTRQVPFERCIAYVAENLAPGVSSSSAGTAAAAAAAAAAAAAATPPPTAGEPRSPSSKRSSGFWGQEAGWDACHEISAESGEGVEEVFRVVARKLVEQNRKLQQALLLATATPATPGLESAPDGSSAAAAAAAAAAGYFDGSNPRGSFRLGRDRRSWLFSPAFSPAVTIDQAAANPEQPGDAETAAHTRRRCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6P1</accession>
    <name>A0A367L6P1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6P1"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="253" mass="27294" checksum="CF083D25BB529F5E" modified="2018-11-07" version="1" fragment="single">QGQAISPAPQPYVNANGPHRAPSAVAPRRFHLGAAPPPFSFIANPIPVLRTHRPLTGAGIYSAPDLPANSMLFATRQTDIHDRFQYGKAECGSIWQSLNQSAQQTNSHVVRSADILQNNKPVTNGASPTAEPKTGLRRARIVVAGSKTGGDFPSHHGTRKAGPEQSFRSATQQFVSLCVVQIQIKSVNKETEGERFEKKQRAQNKYPWLSIQTLGLSLSLDTIGIVLAAHGFEGRAGREGKKSCSPGGRLRYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L764</accession>
    <name>A0A367L764_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 17">Homoaconitase, mitochondrial</fullName>
            <ecNumber evidence="5 17">4.2.1.36</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16 17">Homoaconitate hydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">L249_8572</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 17">Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 17">
            <text>(2R,3S)-homoisocitrate = cis-homoaconitate + H2O</text>
            <dbReference type="Rhea" id="RHEA:15485"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15404"/>
            <dbReference type="ChEBI" id="CHEBI:58174"/>
            <dbReference type="EC" id="4.2.1.36"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="17">Binds 1 [4Fe-4S] cluster per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-alpha-aminoadipate from 2-oxoglutarate: step 3/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 17">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.36" evidence="5 17"/>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L764"/>
    <dbReference type="STRING" id="1330021.A0A367L764"/>
    <dbReference type="OrthoDB" id="10262323at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER01027"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004409">
        <property type="term" value="F:homoaconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01674">
        <property type="entry name" value="Homoaconitase_Swivel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000013">
        <property type="entry name" value="Homoaconitase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004418">
        <property type="entry name" value="Homoaconitase_mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039386">
        <property type="entry name" value="Homoaconitase_swivel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050067">
        <property type="entry name" value="IPM_dehydratase_rel_enz"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00139">
        <property type="entry name" value="h_aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822:SF2">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43822">
        <property type="entry name" value="HOMOACONITASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 17" id="KW-0408">Iron</keyword>
    <keyword evidence="11 17" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="14 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="13 17" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 17" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="19">
        <location>
            <begin position="71"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="20">
        <location>
            <begin position="554"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="521"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="532"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RCI10270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="755" mass="81302" checksum="4E710D49D62A7F12" modified="2018-11-07" version="1">MSACSSSPGQACLQHHTSTGNTSSPTHHHVQTVSACRYSRLLSTTRRTLASEQQGPSSPSGKRSPQTLTEKIVQRYAVDLPQGKLVRSGDYISLAPQYCMTHDNSWPVALKFMSMGATKVQRPQQLVMTLDHDVQNTSDSNLLKYRQIEDFARRHGIDFYPAGRGIGHQIMVEEGYAWPGTMAVASDSHSCHYGGVGCLGTPVVRTDAASIWATSRTWWQIPPIARVTFTGTLPAGVTGKDVIVAACGLFKADVLNHAIEFTGSEETMASLPVDSRLTIANMSTEWGALSGLFPIDRTLERWLRDKATEAASFDKRTTRRRIYQERIDELFAKPLAADTGAVYAKQLYLNLSTLSPYVSGPNSVKVATPLAELAQKNIGINRAYIVSCTNSRASDLAAAAKVFKDAAKANPTTSPRIAPGVSFYIAAASAPEQEAAEDAGDWQALLDAGAQPLPAGCGPCIGLGRGLLEPGEVGISASNRNFKGRMGSRDAQAYLASPEVVAASALRGVISGPGAYQQPADGTNVDYGFGTGSQHDAGNSQQTESSVEQPEAVEMESKSATEILPGFPERICGEIVFCDADNLDTDAIYPGKMTYQDNVSKEDMANACMQNYDPEFRNVAKPNDVVVGGWNFGCGSSREQAATALLAKGIPLVVAGSFGNIFARNSINNALMGLEVPRLVERLRARFPPADRRPTRRTGWTLTWDLKRSVVEVREGEDGEVWTERVGELPPNVQAIIAAGGLETWVRAEIGVRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L789</accession>
    <name>A0A367L789_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Branched-chain-amino-acid aminotransferase</fullName>
            <ecNumber evidence="11">2.6.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_8462</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-isoleucine + 2-oxoglutarate = (S)-3-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:18321"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-valine + 2-oxoglutarate = 3-methyl-2-oxobutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:24813"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="EC" id="2.6.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.42" evidence="11"/>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L789"/>
    <dbReference type="STRING" id="1330021.A0A367L789"/>
    <dbReference type="OrthoDB" id="1732691at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052656">
        <property type="term" value="F:L-isoleucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052654">
        <property type="term" value="F:L-leucine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052655">
        <property type="term" value="F:L-valine-2-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01557">
        <property type="entry name" value="BCAT_beta_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.10.10:FF:000004">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.10:FF:000005">
        <property type="entry name" value="Branched-chain-amino-acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018300">
        <property type="entry name" value="Aminotrans_IV_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033939">
        <property type="entry name" value="BCAT_family"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01123">
        <property type="entry name" value="ilvE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009897">
        <property type="entry name" value="PRK13357.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825:SF44">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11825">
        <property type="entry name" value="SUBGROUP IIII AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00770">
        <property type="entry name" value="AA_TRANSFER_CLASS_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 11" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7 11" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI10297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="406" mass="45093" checksum="302CC93E7AB518B1" modified="2018-11-07" version="1">MASSASLRRSVLSSLRPFLACRPYSIKAQAASAAGPGHILDVSRLTMTETQDRKPLMKLEDLVFGKEFTDHMLSVEWNQNDGWLVPRITPYQNLSLDPATCVFHYAFECFEGMKAYKDAHGKIRLFRPDMNMARLNKSAARIALPTFESTSLVELICKLLKLDSRFIPSQRGYSLYLRPTIIGTQKTLGVCPPGSALLFVIASPVGPYYPTGFKAVSLEATDYAVRAWPGGVGDKKLGANYAPCIVPQQQAASRGFQQNLWLSGEEEYVTEVGTMNMFVATKNKQTGQRELLTPPLDGTILEGVTRDSILQLARERLVPEGWAVAERKFTMREIHEASLDGRLIEAFGSGTAAIVSPVRTIGWKGERVNCGLKESEETGEIAAKMKNWIEAIQYGEDEHDWSYKVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7B8</accession>
    <name>A0A367L7B8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Chitin synthase A</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Chitin-UDP acetyl-glucosaminyl transferase A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Class-V chitin synthase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">L249_4301</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:16638"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the chitin synthase family. Class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367L7B8"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003774">
        <property type="term" value="F:cytoskeletal motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000010">
        <property type="entry name" value="Chitin synthase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000014">
        <property type="entry name" value="Chitin synthase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF13">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="741"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="778"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1046"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1437"/>
            <end position="1460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1472"/>
            <end position="1491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1498"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="17">
        <location>
            <begin position="806"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="domain" description="DEK-C" evidence="18">
        <location>
            <begin position="1731"/>
            <end position="1787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00075290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00083633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RCI10324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1789" mass="198829" checksum="8FAA84678C9AE905" modified="2018-11-07" version="1">MANRMSMFSASSDSPAGSRIGGPQTAQVSTTTLLNAIHNIYLSSDSHQLDASTSLVVNTWLTASRDGPTVDASLAARAWEHARRRAEDGCVLLGSLHQSTPSVINSFLSSFPFALPSSLNQALDAIQPFIRCVTPYSPSTPRQAALGVTLTLNLNGNLTAASLALSQGGIDTVQGLLKIPAEAGYRAFDVFYYLLTSASTPAEREFLGLEAPANYKILARSQTFTPPAYLPTADDAASADDFRQALKDIGIKGSAHRNFISVLAGLLKLGNTLGYTVESDELAEICEDVSGLLGLEPEVLLHQCSTDDRWTLIGGLYESLVDWVISKANAAIASQMDRVVAGDESLDGRGTSNPVAQHDNGDTVSITVVEIPRTTLGKALCMRSIFDDSQGINAEMIEDGVQAPPAGSSVLREMQQAVSEVAPDLGVMTGPQGRARQLELEKREQVLEKVAFAADEDGFLKKLLLPVHGQGINLGRAGRIDLPAMLSSNRLWYHLCLHPTDDSPAQLATLPSVTSAWSAGTVSRQLRSWRLPEWANRRKRNLDFTADFDLDEFAQRYAALGCKDGKDGIENWMLERGWSNGEVRVGKERVWMRESAWWEAEGMLDLKPAPGHTPMQVGAPVNPFGSGLDTGYSTGGAGYFAPQMMDPNFSASNDQLLHSRNFSQGNVSQMTLNHSPNPAPSIAHTASRVASNGDYGLGTKGDTFKGDVYYNDEGEFTGTMDPELAKNKHIQTKEVTFGRRVWVWIVWALTFWIPSPLLRFVGRMRRPDVRMAWREKVVLCFLIFLINAIIIFWIIAFGRLLCPNFDKAWSSKEVSYHQGQDDFWVSIHGRVYDISNFWRRQHSDTNIKTTSDNMMPLAGLDMDDYFPIPLNLACQGLGIKETTRLQPNNTAEFANAIHTSGYFQPVPNSALHKNDWYWTNFEPAIKEFYNGDLVFSQSLVESSGKDLQRMWARYDDKVYDLTDYFHTQDIFVNTDIYKFLHPKVSDLWRNNPGQDLKQMLDGVIKDSISDPADHAKIMNSWLCIQRVFYKGMTDFRETARCTVNNWILLAFTIMVCAVVLIKFVSALRFTSKRRPSPQDKFVICQVPAYTEGEDSLRKALDSLTALQYDNKRKLICVICDGVIVGQGNDRPTPKIVLDILGVDPKVDPPALPFKSVGPGSEQLNYGKVYSGLYEYEGNVVPYLVVVKVGKESEQTRAKPGNRGKRDSQILLMSFLNRVHHRAPMNPLELEMFHQVNNIIGVDPELYEYLLMVDADTSVEEDSLNRLVSACAHNAKIAGICGETSLENDEKSWTTMIQVYEYFISHHLAKAFESLFGSVTCLPGCFSMYRLRTADKGKPLIISDAVIKDYSICDVDTLHQKNLLSLGEDRYLTTLMTKYFPFMAYKFVPDAQCKTAAPESWSVLVSQRRRWINSTIHNLVELMRLKEMCGFCCFSMRFVVFIDLFGTIILPATCAYLGYLIYRVASHTGQFPLISIVMLAAVYGLQALVFILKRQWQHIGWMVIYIIAFPIYSFILPVYSFWNQDNFSWGNTRVVIGEKGNKQVVAVDGEGFDPRSIPLQRWDDYAVANSLPGRRGGYQEKQDYGYGDQYEMDEIKSVYSAAPAGSIMTGMGGRGSLMPSQSPAPGHGQRPPTVNMPYQDASASLRRQSFMSLGTVAHDMRSQTPYQDFPAGRPGGMPTWRSMSNLGPVAGGGLPGSRSVSALGYAGGHRPPLGNEGMQSTASFDFQRGPVVADDIAIIEAIQGVLREVDLDTVTKKQVRALVEQRLQTELIGERRTFMDRQIDRELENM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7G5</accession>
    <name>A0A367L7G5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7G5"/>
    <dbReference type="OrthoDB" id="4927304at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="161" mass="18111" checksum="1527BB0C568EB7B3" modified="2018-11-07" version="1">MARKTRHDTTNNKPSSSPPSKEEETTATFRLYQGTLLAGYEDKIRNELMDLVHQIETETKTCATASQREDLGNVVASYAEAHANGDGDDDGGDEEARRPLLEEEKMADVLLSIRNKFRDTVDGQAGESGTAYAKLINWYSRELDKLAREKMKGKKEQKKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7J2</accession>
    <name>A0A367L7J2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Cytochrome b-c1 complex subunit Rieske, mitochondrial</fullName>
            <ecNumber evidence="12">7.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L249_4430</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="12">Binds 1 [2Fe-2S] cluster per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="12">The Rieske protein is a high potential 2Fe-2S protein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Rieske iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="12"/>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7J2"/>
    <dbReference type="STRING" id="1330021.A0A367L7J2"/>
    <dbReference type="OrthoDB" id="1637982at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd03470">
        <property type="entry name" value="Rieske_cytochrome_bc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.102.10.10:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit Rieske, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.270">
        <property type="entry name" value="Ubiquinol cytochrome reductase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037008">
        <property type="entry name" value="bc1_Rieske_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014349">
        <property type="entry name" value="Rieske_Fe-S_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005805">
        <property type="entry name" value="Rieske_Fe-S_prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004192">
        <property type="entry name" value="Rieske_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006317">
        <property type="entry name" value="Ubiquinol_cyt_c_Rdtase_Fe-S-su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01416">
        <property type="entry name" value="Rieske_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10134">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02921">
        <property type="entry name" value="UCR_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00162">
        <property type="entry name" value="RIESKE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81502">
        <property type="entry name" value="ISP transmembrane anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rieske" evidence="14">
        <location>
            <begin position="163"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCI10389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="260" mass="28086" checksum="4E05F463495270D6" modified="2018-11-07" version="1">MATPLLTTASRIARSPRRLARSLPCPQLRTVIIPSPSADSTTTTYTSPFKPKETPFPDFGKYVSSKGEGSNKLMSYFMVGAVGAITAAGAKSTVQEFLVNMSASADVLAMAKVEDADCAVEFLVNMSASADVLAMAKVEVDLNAIPEGKNVVIKWRGKPVFIRHRTEAEIEQANKVNVASLRDPQTDDDRVKKPEWLVMLGVCTHLGCVPIGEAGDYGGWFCPCHGSHYDISGRIRKGPAPLNLEIPEYDFPEDGKLVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7W0</accession>
    <name>A0A367L7W0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_4338</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367L7W0"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19146">
        <property type="entry name" value="AKR_AKR9A1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF7">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="31"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI10510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1327" mass="147765" checksum="0306BA5F4C7F67BB" modified="2018-11-07" version="1">MLDVLPSAPPPKSPLARYRLLSPTAAVRVSPLCLGAMSFGDNWKNWMGACDQASTEAILDFFYDQGGNFIDTANNYQFQQSETWIGEWMKKRGNREQMVIATKFTTNYTAGPNAPNIMANFVGNGSKSMLTSVNASLKKLQTDYIDLLYVHWWDYSASIPELMQSLNHLVACGKVTYLGISDTPAWVVSKANEYARNHGLRQFSVYQGNWSAALRDFEREIIPMCKSEGMALAPWGALGGGKFKSEAQRQTAEGRQTDYPEQDVRASQALEAVARRKNTAITSIALAYVMHKTPYVFPIVGCRKIEHLKGNIEALTIHLSKDDIKEIEGANTFELGFPHNFLWPNGVPESESEVWLLNMGGAFDYVKDAAADASSLGTKWILATVCEKRMVIEQTSMGRKREHAVDDATGACRSMNRRINVRINIRDAILGAPSLVRILQGVAAATKGPHDCLAPILHWLRSAPTPKATAAVGVGGEDAQPASRRLSLDDWQRAIATELSVADDVSHHLLNVALALSLLRERGRQQKPVARANGLSQCWDLVRGAMTADGPTADLFTASRNSQGFLTVPLCSILSSEGDIDELFRLHVWLPDQQRGNPDLALHSHQCFGQGWILAGQAEDCVYDVQDAADPAEATHAEYSLAWNDGTSLDSTYKVHPPSSVIKNTGRLVKATATHIAVHTRDASYTIPANVTHRSRVEPLAFHATLFFFDSHRGFVKGAGVLGPKDGDSVTHHRAETLSTPRVLAQQVDDVRTWELLMDQGRRHARHTDWEHALRAFDRALSLCQSSQCFPNAAHFRHLTLGELGSTNRRFGRYGTAKDILESVIAEMDPNAHQVEFQGELGVSYRHMNRLEDAKSAFECQYSTAERLGLERQMCRAVGNLGMVNYQLSRQHKDEQLLDAAIRQLVQRVDMARRLSTQDEKSSLKTWEIIGLGRLSLCHSARGNVAEAVSTSLAAHELAKDSPDATVRAMTRFLYGRALLLQGRRMEALSLFNVPGTCSPAIAFAKEPSQEHRTYLGELVDIGANMNIVDHEGYTALDHAVFNGDAETEAMVLAGLRKNAAQKIELQLADARLRKQYRELFQEHMRPVLLSGGIGCLQQLRQAYVQALVSDESKKHVFDSLKFVPWRDFAALGRLPAFNDGKVAEWLSVKHGASQEQSADFLVFISYRWMKKATDATSPDDDEHTQYLRMKAAAEELLRLHPSIDEQRLGIWADYACIDQADPGAGVSALPLIIAQCNAMISLVDDDYYDRAWCSVEVLMAQTLRRSYGLHLWYEQVKRSDESAELLCEWELREGMGRDIGVDNKRLTYEEDRPKIMFLERQSRLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7X2</accession>
    <name>A0A367L7X2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7X2"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="278" mass="31933" checksum="5E6B8DB9FCD7411D" modified="2018-11-07" version="1">MTTSMSLPQHQRAKKKKTSQPRHSRQDMNIPIDDTNRNPQVLTREQNLRLARLALVRRQLHHPQLGPQLGRVLIVAKVRLRRVRPRKPLHLLERLLVELEGQVEGLGDGLVGDVIVSVDLRTQGRMKKKKKEEEDGGQLLKGEVKLMGGAPSRRSYPAAGTTHATNSLDNLPLLILDNLDSPQALAAEKKKSKRQRKRPQRQERRKKKTHDTKREAPFRHVRRVRLTRQLIQFVSHRQPGNRIISHQQSKKKSAAESKGKKRTNEKTHLPSHQGPHHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L850</accession>
    <name>A0A367L850_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L850"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="122" mass="13753" checksum="391B39AD01585BE6" modified="2018-11-07" version="1" fragment="single">CKATWNKLQPLHRSARYTNSGHSARSVVTAVITVIVTAIDALQIVRLIYNVKVFLQITYLLSVTYSHVILQLYYFFNTITSPAFNSSSILTKPLSRDSSSSSLSRDPHLDYSLLFPLPQITF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L863</accession>
    <name>A0A367L863_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L863"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017034329" description="Secreted protein" evidence="1">
        <location>
            <begin position="30"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="71" mass="8068" checksum="6670A27332FFADA8" modified="2018-11-07" version="1">MLAIISTCNCKSLYLVPLLSFSFSIALSAAPPDRAPRDTIGVLILYRRLYNPIRLGRNRPRPLYLLPLLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8C9</accession>
    <name>A0A367L8C9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_4236</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8C9"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI10671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="62" mass="7239" checksum="0617C395A2637977" modified="2018-11-07" version="1">MKVRKADADDSSKYFSRYFKVPTCSTLTYLYKIGDLEEDLYVPYPAVSAVLRGVWVRIRPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8I9</accession>
    <name>A0A367L8I9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_5173</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8I9"/>
    <dbReference type="STRING" id="1330021.A0A367L8I9"/>
    <dbReference type="OrthoDB" id="1306014at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20908">
        <property type="entry name" value="SUF4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000354">
        <property type="entry name" value="C2H2 finger domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23215:SF0">
        <property type="entry name" value="BUB3-INTERACTING AND GLEBS MOTIF-CONTAINING PROTEIN ZNF207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23215">
        <property type="entry name" value="ZINC FINGER PROTEIN 207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="9">
        <location>
            <begin position="13"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="42"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="268"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="281"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI10731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="34879" checksum="1F269A731CB0B202" modified="2018-11-07" version="1">MGKKKRGHPDIEDVLARPWCYYCERDFEDLKLLISHQKAKHFKCDRCGRRLNTAGGLSVHMNQVHKETLHQVENSLPNRQGLDVEIFGMEGIPQEILDQHRNRIIQNFYQAQEDRRIATGNPLPGQGGQHKRKKIKMETGEELKARVNDWCSKRKAEKEAAANEAEDVAAAAAAAAAAAAAAAAAASTAAATATATAATHAASAQYGGQYQQSQPGVEQSPFAYQAGSIAARPPGSMGPPPGLPQRLPEGWNAAAGDDIDRMIRMAEAGVKTASKPESGAEGEKKSKKDKKGRLVYDDAEVSPEEKMALMPRYAFVPGPEATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8M6</accession>
    <name>A0A367L8M6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8M6"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="356" mass="38574" checksum="6E250F02D861F3F7" modified="2018-11-07" version="1" fragment="single">LGLAWLGNTREQANNCLNRQPGVQSDVVVIAAAVLCRLCLVRHVRIDLPKFWKPRERRMGHVVVLSNDEEAVPVLVVARPLPLPMHAGVSGNGEQKETRRDAMYQVHVCYFIREPPPFPVIRVRMERASMRLTDGRNLTMPYHFSVQYGCDRDPVAAYCEWLPISLGTDKVAPSSKRFPLSPSLLRLCLCLSSPLLSSLPLLSSSLTIVRQRGKKRLNTIRPSMAAISLFAYTVCRVSSSSASSFSAASSSVSSSASPSASPSASSNTHLSSSRLSPYPSSRTRLSSSMPPPLNLSGSQASSTSACLLLGFGPPLIPPSFSHSVQLYPGLSSRNLSTTRRQLLVSQTATLPLPGPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8R0</accession>
    <name>A0A367L8R0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_5418</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8R0"/>
    <dbReference type="STRING" id="1330021.A0A367L8R0"/>
    <dbReference type="OrthoDB" id="25391at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052073">
        <property type="entry name" value="Amide_Lactam_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171">
        <property type="entry name" value="FARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171:SF3">
        <property type="entry name" value="FARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="316"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="643"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="823"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="659"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="684"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="828"/>
            <end position="845"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI10807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="894" mass="100027" checksum="950E222FE52A68FE" modified="2018-11-07" version="1">MTVFTRQRASRACELMTTQVRCDAASLGVPCTNCVAFQIECRIPTPKRKKPVKMLFGSLRCSDADVELYYSERELLDDHQPRLSSGSCTANQRIPTIIHSLDGTPSLPQTEAQIRQDEVDSSTYLNLVMKPKFTRAPITEAGRVAYLGESSNLTLLVDDRQGSSDVVHYPLPENIRGSRARLTELDVVEIDILHQRGAFLLPPRSLCDELIDAYFKWVHPIVPVINRNRFLKQYRDLQNPPSLLLLQAVLLAGSRVCTNTQLMDANGSTSPAALTFYKRAKALYDANYEDDRVTIVQSLLLLGWYWEGPEDVTKNVFYWSRVATIVAQGSGMHRSVEQSQLSKSDKRLWKRIWWTLFTRDRSVAVALGRPVHINLDDSDVEMLTEDDFVEDDPDIVSESQPDAVHVQFFLQYVKLCEIMGLVLSQQYSVASKGRQWNAIDLTHSDMALADWLRNCPRIVYWEMPRHHFWSALLHSNYYTTLCLLHRAHMPPGGSGRLPTESPYPSRNIAFQAAAMITSIVENLAIHGELRFCPAFIVYSLFSALIMHVYQMRSPVPSIQQATQDRLRSCMEAMKEVSRVWLVGKMVYTLFESIIGNKTLEERLQKAGAKRHRKIQQSLSQLAQQTTRSCDVSKRKFDDIAIDFTANAPTPQESYERSRPQTPSASFKNDSGNAMQPPDVPSPSARPTSGTDTFMGGTSSRPQTRPASPVYPSFSLPATPPDLYLVTRNSPNLSQSLWENFQPEQLFPESSSMPVMPSLSPTQAHQNLDHNVMARLTSSSLAPEPPSQIATHYSVRSQGQGNGFTPVHGFQAQPPSLWQSTVDLGIHDGQSPESWSSSSAQGQSAPTTLNVEDCSSALTAARCSHFHIMPCRSFLPDLPMEESFGAHATLSVSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8R7</accession>
    <name>A0A367L8R7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8R7"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="76" mass="8933" checksum="C592257640079FD7" modified="2018-11-07" version="1" fragment="single">REEEEESRDSLKEAIEEELEAGEVFVLRRYFSRYFKVSTCSTLTYLYTCTCRSDRSNRSDPMTPAITAMTRPLRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8Y8</accession>
    <name>A0A367L8Y8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exocyst complex component SEC15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_5448</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the SEC15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8Y8"/>
    <dbReference type="STRING" id="1330021.A0A367L8Y8"/>
    <dbReference type="OrthoDB" id="10267033at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090522">
        <property type="term" value="P:vesicle tethering involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.30:FF:000004">
        <property type="entry name" value="Exocyst complex component SEC15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.670:FF:000004">
        <property type="entry name" value="Exocyst complex component SEC15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.670">
        <property type="entry name" value="Dsl1p vesicle tethering complex, Tip20p subunit, domain D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.30">
        <property type="entry name" value="Exocyst complex subunit Sec15 C-terminal domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007225">
        <property type="entry name" value="EXOC6/Sec15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046361">
        <property type="entry name" value="EXOC6/Sec15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042045">
        <property type="entry name" value="EXOC6/Sec15_C_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048359">
        <property type="entry name" value="EXOC6_Sec15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042044">
        <property type="entry name" value="EXOC6PINT-1/Sec15/Tip20_C_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12702">
        <property type="entry name" value="SEC15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20651">
        <property type="entry name" value="EXOC6_Sec15_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04091">
        <property type="entry name" value="Sec15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF025007">
        <property type="entry name" value="Sec15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component EXOC6/Sec15 N-terminal" evidence="8">
        <location>
            <begin position="50"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex subunit EXOC6/Sec15 C-terminal" evidence="7">
        <location>
            <begin position="404"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="537"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR025007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI10874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="768" mass="87508" checksum="5075B1AE3406417D" modified="2018-11-07" version="1">MDRRQTAFEDFTPIIILSTSDSEFLDHLIPVLKDAAYSKTIPALTQCLIRYSDDREADTERIGLTKHEEFLSSVGRLQTVREGTVSLTAEILQLNESIQNSTESLAEQKGALVNTTAIRHNIADTANALKESLQVLHAVNNSHDLVRRKKYYSALKSLEDVQNEHIVPILQNRYATQHRLAHVIQKSIPGSQKAISEAVMTDLNTWLFRIRETSQFLGEVAFYHTELRRSRQRKRVENDEFLSNFKLNSSIELVCDESEEVDVLNNEELQVDFTPLFEAMHIHDALDQSDRFRSQYAATRRQQKDLLLPNSIELLADDETSLSSLLEGIAGFAIIEKATMRRAPHLRSAIDVEELWESMCSAAITLTAKAITDVSNAEILLKIKGVIALFVQTMEGWGYSISLLDSFLLTLFDKYAELLKRRFSEDFQEIVSTDDYMPMAINSVEEYEKVINVSWFTQDQSIEELKFPSVLPFSQMYPLCCIDIRNFLNQFYFFSDDHFQHSDAIDETLRKSLDELLTQKVCKSLVERLSSQYLGQIVQILINLEQFEVACQELEQLLIRARSSTSAGGPLKLNATEEFRMNKKTAEKRIFELVNSKIDDLVDTAEYDWLASTLISEPSNYMQTLTRYLSNIMNSTLLGLPREIKELIYFDALSHTANKILALPLSPEVKHISSCGVSALAQDVRYLTEFVSSLENGPMLRENLDELQQTINLMQSDNFDEFFDISTRNKKYGRVDALNGPLLLEKLTPVTPTTGPLSNISSRFALMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9N6</accession>
    <name>A0A367L9N6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L249_7283</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:16638"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the chitin synthase family. Class IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9N6"/>
    <dbReference type="STRING" id="1330021.A0A367L9N6"/>
    <dbReference type="OrthoDB" id="370884at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054295">
        <property type="entry name" value="CHS4-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF16">
        <property type="entry name" value="CHITIN SYNTHASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22997">
        <property type="entry name" value="CHS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="521"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1082"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1107"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1133"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase 4-like" evidence="14">
        <location>
            <begin position="424"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="75"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="624"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1218"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="169"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="182"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="630"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF22997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCI11129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1238" mass="138699" checksum="97C70D0038653AB4" modified="2018-11-07" version="1">MSLPERPGSSPPHDDRSSYRHSPSRRQPAVDVEAAGYHSISRTRNHHHHHHHHDHQRGKSASSFAETITNPNYNLDTLPLSSADHASHDGQASSEQPFSRKRSLIRPERTRIGKDHRNYHYHKHAANMDVLPSSTGNDPILEHLDGSTERSGGSQANGSFTDSPPRPHTGRDGSTEQEKAHAHARTRPARPKSSKITKQTKGERRPSRKKQKGAEDQLRPPSLWNVYCAVITFWCPDFILRCFGKPTKAQRRAWREKMGLISIILFIMAIVGFLTFGFTAVVCSAPPLRLRTNEVTGGYMIFHGVAYDLANSHHPAARGLPLRQDGLGANVLFDLPEKHSGQDGSFLFQNVNGKCKGVITLAPGSDVPTNADDELAWYFPCTTFNQDGSTQPNLTIPYYLGYACHTTQNARNAFYRDLSGAADVYFTWDDIKNSSRNLIVYSGVVLDLNLLYWFNESQVAIPDRFKELRDANSAVNKAVRGRDVTRLFQSSDDKRYAQCFEEIIKVGSVDTETVGCIASKVVLYCALVLILSVVLSRFMLALVFQWFISRHYAASKTSQSSNRRKRNQQIEAWTEDIYRAPARLPGDLGSTVVSSDRMTNKRSSSFLPTTSRFSTVYGADRGGNLRRLPTTMTSQGTTGSLLSPHSIYRNGNDSRASFLRSDTYGSSNAPEGPGPAGFIHDAVVPQPPSDWMPFGFPLAHTMCLVTAYSEGEEGIRTTLDSIATTDFPNSHKAIVVICDGIIKGKGEAVSTPDVCLGMLRDHSTPPELVQPFSYVAVASGSKRHNMAKVYCGFYDYGARSQIPVDRQQRVPMMVIVKCGTPAEEAANSKPGNRGKRDSQIILMSFLQKVMFDERMTELEYEMFNGLWKVTGISPDYYEIVLMVDADTKVFPDSLTHMVSAMVKDPEIMGLCGETKIANKRDSWVTAIQVFEYFISHHLAKSFESVFGGVTCLPGCFCMYRIKAPKGGQNYWVPILANPDIVEHYSENVVETLHEKNLYLLGEDRFLTTLMLRTFPKRKQVFVPQAVCKTTVPDKFMVLLSQRRRWINSTIHNLMELVLVRDLCGTFCFSMQFVVFVELMGTLVLPAAIAFTFYVVITSIVHSPPQIIPLVLLALILGLPGVLIIVTAHSWSYVIWMLIYLLSLPIWNFVLPTYAFWKFDDFSWGDTRKTAGETKKGGGHGEDEGEFDSSKITMKRWAEFEREKRSRSVSYWNARENAMTSSTWTVPPGNFQEDYPSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9Y4</accession>
    <name>A0A367L9Y4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_7762</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9Y4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016653963" evidence="2">
        <location>
            <begin position="20"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI11225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="92" mass="10046" checksum="50641B65EBFA2F7D" modified="2018-11-07" version="1">MCRLSFLACYCSIIIHAQAAFDGYLLGSKQSPEAGEFSLTSSTTFLFVPTVLFVLSSSFLISCQNYFPLHPSVAVFITRLPSLPLSFKIGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAB6</accession>
    <name>A0A367LAB6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH myb-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_7132</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAB6"/>
    <dbReference type="STRING" id="1330021.A0A367LAB6"/>
    <dbReference type="OrthoDB" id="3366990at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010833">
        <property type="term" value="P:telomere maintenance via telomere lengthening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11660">
        <property type="entry name" value="SANT_TRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000137">
        <property type="entry name" value="MYB DNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013867">
        <property type="entry name" value="Telomere_rpt-bd_fac_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052833">
        <property type="entry name" value="Telomeric_DNA-bd_trans-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47807">
        <property type="entry name" value="PROTEIN TBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47807:SF1">
        <property type="entry name" value="PROTEIN TBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08558">
        <property type="entry name" value="TRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="5">
        <location>
            <begin position="547"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="26"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="403"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="660"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="735"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="800"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="415"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="754"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="822"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="844"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="868"/>
            <end position="883"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI11353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="924" mass="98746" checksum="5CD274ECED016911" modified="2018-11-07" version="1">MAEPAQTEHYAAPYIKQEYDVHAVQLAGQLGPKRPLDHDRRDDPEAKRSKTENVSASDSLDDGLALLVQNALSSVGDLVDQINAKSTTTMHLDTPPQDGPRSSFAVDPQVFIRDMNVHSLANLALSLLHIYVQKPLQQTFDSIRDAESEHGRCYRQLRHSFEQLRLLYTSKPVLYAKDLDPHRKEQRALVELINLAQLGSWLIDGSPQALAEAQDNFLSLFNCQVADLPPGMTELYLGIMAQGAVESLVLRGGEKSVEQLLGEVFLAGLDDKLRRHHGNSELTSADQNFVKSVNSWRETIEREAREQADPTALRQLHPFKCLLRLFVCYVRGRLRCGSYWSSKLDIKLQLGDEDDEAEADAIAVEDGDNVPRKTTDQGLEMELDLDEISSFLEKETSGLVQDALTGLPEDGGSAGAATASDTAKADSGPTRTNGKADLMTDYKELEALVAESTSHYVKTTLNGLSPVPYQPTVPQSTAEVMASQPPYLHPYYTGYSQHPAEAEQATPGEDLPPNQTFPSAILYDKARQAALCKTTAHTRREGIHSTRRPWSQEEEKALMAGLDMVKGPHWSQILTLFGQNGTISDILKDRTQVQLKDKARNLKLFFLKTSSEMPYYLQAVTGELKTRAPTQAARKEAEVRAKQSSEEDQARLQGIMALAGGLKDPLPPPPSSSSSSSSSSAGFYGKGGVVDDRDARSGTGCDVVCAARSQRWRTYGEDVDAAGWAHVFGAQAARRFDDDERRRRQGSGDGSTGAPGHAASAASSAVSAPASAGAQRRRWRGGAGGLGGSGGIGGGVGGAGAGAGAGDGPRPTMAGSVARAPAPAPFRPRLAPAPAPAPAPVAAPVPGQAAASTTQQTAPAPEVPKAPAPAQAALSTTQQAASALEAPSQTQAQTQDKTRTETDVDGAEAVLLEGLQAVVAQTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAS2</accession>
    <name>A0A367LAS2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_7719</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAS2"/>
    <dbReference type="STRING" id="1330021.A0A367LAS2"/>
    <dbReference type="OrthoDB" id="541883at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043504">
        <property type="term" value="P:mitochondrial DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009411">
        <property type="term" value="P:response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1420.10">
        <property type="entry name" value="Rubisco LSMT, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015353">
        <property type="entry name" value="Rubisco_LSMT_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036464">
        <property type="entry name" value="Rubisco_LSMT_subst-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004601">
        <property type="entry name" value="UvdE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00629">
        <property type="entry name" value="uvde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31290">
        <property type="entry name" value="UV-DAMAGE ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31290:SF5">
        <property type="entry name" value="UV-DAMAGE ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09273">
        <property type="entry name" value="Rubis-subs-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03851">
        <property type="entry name" value="UvdE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81822">
        <property type="entry name" value="RuBisCo LSMT C-terminal, substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="2" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="4">
        <location>
            <begin position="502"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="155"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI11515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="968" mass="108781" checksum="904167A61B86FB3A" modified="2018-11-07" version="1">MPPKRKRSLEAPAPARRSARKSAAVKPDDAGLTEMKRRKPRLAVQNPDLIPPVVDKKPRQRTRKSQPSPPPPSLVEAQAEVDVQMEDAAPEKGARRPPPINSERLPLPWTGRLGYACLNTYLRFANPPVFCSRTCRLSSIIDHRHPLTDPTQTEHATKNRPDKTKPPDVARGLAFVQSLGLANAADIGKMLRWNDKYGINFMRLSSEMFPFASHKEHGYKLAPFASEVLADAGRVAAELGHRLTTHPGQYTQIGSPRPDVVTAAVRDLEYHDEMLSLLSLPGQLNRDAVMILHMGGMYGDKGATLDRFRQNYAKLSDGVKRRLVLENDDVVWSVHDLLPVCEELNIPLVLDFHHHNIVFDPVMREGTQDVISLFDRIKATWTRKGITQKMHYSESVAGAVTSRNRRKHSARVKTLPPCANDMDLMIEAKDKEQAVFELMRTFKLPGWHLFNDVVPYERDDEPRKAVLKKKIKKGKKAGGDDEVEVIAPEREVSPESVSMGGPENRVYWPEGMEEWLRPKKREVKKGVARRDIPAGTVLCTIPRKAILSIETSDLGHRLRELSSHLDDRQTPPLTDLDSWSGLILVLIYEHLLGPDSRWEPYLHLLPESFDTPMFWSEEELAELQASALPSKIGRREADDMFRDLILPVIRARPSVFRSSEGYSDEMLLRLAHRMGSTVMAYAFDLGGDDDEDDDEAAQDGWVEDRDEKMLMGMVPVADMLNADAEFNVCSTHLFPLTNNNDQLTPSNTKAHVNHQDHHLTITSLRPIKAGEEILNYYGPHPNSELLRRYGYVTAKHARYDVVEIPWSAVEEATAAHLSLSRHQLDKARDGIDPEELEDTFVLERESGEPKSDGTLDGPASVSELPADLLHQLDALLKAAPKSDKRGRDEAQTAILARVLTAIESGYPTSIAEDELLLQRDGLEARRRMAVLVRLGEKRVIDEAKSFLSDAAPRRFKKVKAGQDDQDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LB67</accession>
    <name>A0A367LB67_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ras modification protein ERF4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_7215</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Interacts with ERF2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LB67"/>
    <dbReference type="STRING" id="1330021.A0A367LB67"/>
    <dbReference type="OrthoDB" id="5377273at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031211">
        <property type="term" value="C:endoplasmic reticulum palmitoyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019383">
        <property type="entry name" value="Golgin_A_7/ERF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051371">
        <property type="entry name" value="Ras_palmitoyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254">
        <property type="entry name" value="GOLGI AUTOANTIGEN, GOLGIN SUBFAMILY A, 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13254:SF0">
        <property type="entry name" value="GOLGIN SUBFAMILY A MEMBER 7_ERF4 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10256">
        <property type="entry name" value="Erf4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Golgin subfamily A member 7/ERF4" evidence="8">
        <location>
            <begin position="50"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI11663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="199" mass="22234" checksum="5CE01F6D41400F48" modified="2018-11-07" version="1">MGDDLPPAGTNNNNAHGANAEEEWGPQHPCYPHLNPHVPVTSAEYSTTRIIRIRRDWLPHGDLAPTLSNLYPEILDPAGLSEHEFRRVIDKLNLELVAAFNPFGFRNLLDALLGLLTGWLWDDLGFTAVKSRLDRLERWIESWNRDMEKTLAVDDGLTPPKMIPLRQTAYMTLDIQIADPEIAPAPTSVTAGESHSPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LB75</accession>
    <name>A0A367LB75_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LB75"/>
    <dbReference type="STRING" id="1330021.A0A367LB75"/>
    <dbReference type="OrthoDB" id="5344482at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="247" mass="26554" checksum="34366934995DD650" modified="2018-11-07" version="1">MDRPWEPCRPVAGPSPTASTTEVVGGHLARFEFSDDGTKVLMVESPALDPVSASPAAYCWRVTWPGKSPTTALPAPDDESRRLYFLLSPDAPIPPTVTIESPGRPNIAVKSLPAIFPTGFDAEVGVRGVLHTLWAKKRLLELQREMETELTTNAEGVGLEMVLAERQWIMDTFLCPSASLPPKPRSSPKNLRLATSSTAISSLAGVLCGPGHEQPNTTGPQDDEDGLFALPMSPRSPEERSGPYSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBG0</accession>
    <name>A0A367LBG0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Yos1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_7259</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the YOS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBG0"/>
    <dbReference type="STRING" id="1330021.A0A367LBG0"/>
    <dbReference type="OrthoDB" id="15356at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013880">
        <property type="entry name" value="Yos1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15858">
        <property type="entry name" value="IMMEDIATE EARLY RESPONSE 3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15858:SF0">
        <property type="entry name" value="IMMEDIATE EARLY RESPONSE 3-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08571">
        <property type="entry name" value="Yos1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI11572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="85" mass="9272" checksum="D92ED23E24198E7E" modified="2018-11-07" version="1">MLFFGFGNLFYIAVLLINAVAILSEDRFLARINLSPASYDPAFGIGADASIKAKIIHLIASVRTLMRSPLILVNSAIILYELVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCT0</accession>
    <name>A0A367LCT0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_0024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCT0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI12230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="38" mass="3968" checksum="40E069757409E4D5" modified="2018-11-07" version="1">MDEAAGTTTAKSFVTALESLGGLHLEAGIAHREELEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LD25</accession>
    <name>A0A367LD25_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LD25"/>
    <dbReference type="STRING" id="1330021.A0A367LD25"/>
    <dbReference type="OrthoDB" id="5386674at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="615"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="701"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="718"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="818" mass="89102" checksum="19C0667588578CF6" modified="2018-11-07" version="1">MPDSQAAPERTSSFRRMLELERSYMIERLQSKKSPEGSIPNDLPASSPLSQAENIIRRASTVDGDLKPPKSSLSINTKLPIPRLPGESLGFDDATTAVATPAVGTPVAAADTADASAKDTDDRSICVSPSWESHGRRKKEKKLMEKKEREDAARTKKNRLSKQPPPPSSAEALRKAEAVPDPTVARGRVKDRSKSAAAGPVGNEAAQRKPRSRSSSFASLIRSPLSFRRASVDKASPVEPEFVGGIKLELERHMANDRRLEQQQQQQQQHRQLRDETVVHPALRQQARASGDRWPAPLQSHPPSGAATPRETGRAYPPITRQERTYRGRSMAGPPTPVTAPTTPDTGKLDQWRARVGLVPSPQPPTPPTDPDMQLMDDDSDDRDRHGFDDGFDDDDDDDIDDNDDLSLSQSRHKASSSKPSRRPKAPVGLSIFPPPARRSEEADGDGIRRKSSDAQGGYRTAPSTPPEPPRRSPKRSPRANLDNMLPPLPYQNDLISPSEVSPATLTPRTAKRMVVKPATQIVSRNGGVRRKSSKQKHRQSDDSGSDEFHSPSVPSTPATSRTESDGKKASRHLSTESSATGSSVTDGSVVLPLRQQDGGIHEIQAAADKVLASYREATSGSRRQRRESEPAGRGSLPLPVEQQRQAPQKSVRAGGAKVGRASVATTTPGSQPRRTKVRDASPATYLEEARRVPLSGVPARVAKPRLGPPASFTLPGMEDDEDESESVEVARPSLSQHEREPIAKVFVECCHCNFYHDMPSNLYEAMANPEAALSSKGTMEYGSAISMTVKCPWCRHEMSTRCCAGLAAMVFVTERLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDS7</accession>
    <name>A0A367LDS7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_1216</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDS7"/>
    <dbReference type="STRING" id="1330021.A0A367LDS7"/>
    <dbReference type="OrthoDB" id="4177236at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF58">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="2">
        <location>
            <begin position="237"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI12578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="356" mass="40017" checksum="9CF34F2623745880" modified="2018-11-07" version="1">MALPQPSPDPTTTDPNRLSPPPAIEAEQSPSSSSSSGVNIPPTPETNGNRGSQASRKRSRTQLENPPVEPTTSTTQRPVLRKRPHFLRPPLRNGHVLRLERHLQHHDLFLRVEPPPSQHEMVYKTYHRIVSYTGLVVNEWVRIHSQVPVLRFLLPDELTAAPIGRVSRGALLADCWSELTPETKRQVVDSLRGVVNKMRRTLPPAQLQGYPIVGSVITEGYSLLLQKGAGTTYWAIRQRPRAAHFTAFMLSNLRPGLPEAVADSIASQISRTSPLVLSHGELSPSNIVVLNGSVVAILGWDCGGWYPDWWDYVNFFEAHVDHRNRDWFDYASDIFDDMYTNELVAFQAILRNQTPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDU9</accession>
    <name>A0A367LDU9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Pex N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L249_0455</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BCC 54312</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDU9"/>
    <dbReference type="OrthoDB" id="5541877at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039966">
        <property type="entry name" value="C553.12c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40467">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40467:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="597"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="648"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="683"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="717"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="818"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="858"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="886"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="domain" description="Pex N-terminal" evidence="15">
        <location>
            <begin position="157"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="477"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="498"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCI12412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1085" mass="121855" checksum="3B2509CFE6164338" modified="2018-11-07" version="1">MGGAWIESVGVDPRRYRTASSGLDDVINFSSTHCELLFRSSDDASASTPEPCVASVAPLPHLFPFYLSSSACYNKPRPIRFCPVSNSSDDATTTMTDSSFILAQQRVAARHRARQAQLAAADKARHRLLPFSLEAASSREGTRPAFRVSQVDAEFLDDELVELLRVQVGDALRYFADGHLQDDWSAEVSLVLRALLFKLTVWDHDATYGAALQNLRYTDARQDGPVLVAPSRLQKSLYGLVTVVGRYAWTKWEDWLLDEGEPTSFLSRWTWRLSTAHSAGALVSFLVFLLHGRYRTLLDRLLRMRLAPPTSQVSREVSFEYLNRQLVWHAFTEFLLFVLPLVGINRWRRWLDRTWRKTKDMIRTDNDDDASSRGELAFLPDRTCAICYQDQNEDPTTAMMMASPSGVVGSAQTDVTNPYETIPCGCVYCFVCLATRLEGEEGEGWTCLRCGGHVKECRPWSGDVLVRKPSLATKTVAFSSELPEEEEEEEEGRRENMSFFQFTQGTESRTRPSDSSPLLGRYRAVPPPRGSDRLSAGEGRGSVHIGYGALIAAALDGDDDDGDDDAEGRQNGRWFRHLWVAPRQSAVKRVVDRWWRLYGLVVVLPAMLVVGWCAIPLPQYPLQDDGTEQPEPPDKSPGHGAARVRLNFWFFLFVYYGFYSLTALVWITKVFNLYSLNWWPRSLGFPLTLSLIGALSLAVPIPVYLGRETRFLTEHNTAWIAWTFVVMALPVAMALAILMSNERHVGVVRRHSLSETQRIFTSSWWSSEPDQRRRRDDGAAVAALTAAVASAPTATSTATASAVRGGNGRGVGWQPASFVRFLWLCVALLIGLLAYVLGEAYAEIYLRTLPHNSLETVVYVYGWVATVHLLDALTGWTLGIREGERVGSYPLSWVFKLYFTLTYQTYVRALYARLRSPSQFMVLQLLSSTSLVVLTPLSMTRLCHRLLVLTGLNGQSYGSYQKVQARNVFIRFLAENGSMATFLGSVAVLHYGSNRHVYPYFALDDADGPYDLKLTLWASSVTWACELVASFAVRALIRICFRVDVALEGRQDLVVWPELLPTCVTVSLHVLQNMMFSIIRLQFYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LE46</accession>
    <name>A0A367LE46_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ER lumen protein-retaining receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_0668</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LE46"/>
    <dbReference type="STRING" id="1330021.A0A367LE46"/>
    <dbReference type="OrthoDB" id="7694678at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046923">
        <property type="term" value="F:ER retention sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10585">
        <property type="entry name" value="ER LUMEN PROTEIN RETAINING RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00660">
        <property type="entry name" value="ERLUMENR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="272"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="276"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="306"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="319"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI12698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="39214" checksum="CDA29DC97C7D5564" modified="2018-11-07" version="1">MTAWNVFRILGDLSHALSKCILITSMHRNRSAEGVSFITQALYTLVFCTRYLDIFMENSVWNLLFKIFYILSSFYILAVMQWVLPRSRERELSWKLGAAVLGLSLVLSPFMMLMFERVWSFRSWMWVFSEILESVCVLPQLLLLRQTTVPTVIDSFYLLSLGSYRALYCLNWFLREFDDRKPDTVSVIFGLIQTALYIDFAWVYYTRQRVKLRGGGLVDADDMRRGWLLRRIFGKNVDGVDDEENAPALGDDARRINRPKWGARGISVSADEGVLDTERQNRADAEDAADPDAKMRDPDELARALDDDDDDDDDDDDAAAGASSSASRGQLRGMRSGDEWRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEH1</accession>
    <name>A0A367LEH1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEH1"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="222" mass="24080" checksum="6417835B0B1B0B9C" modified="2018-11-07" version="1">MALTPFEAPTTSLQSVDLARWVLIAKVHVHCEPSLVQMRCMCSMVQLGSGTIIDFAAGAAMAVDAARMEAIKVLVTRIDLQSAGVWAIPEQLIDIECLNRHMASIHSLKPRPDTTQQPTLTSSANFSDATLPDGLRQPAFVLTAAVGPAGGPCRERGSDWLTGRYNSQDTQKTKKPSDNTNYYVEWLVTSSPAAQHLERNRAASTLLGIGHEHMSSTLRPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEH9</accession>
    <name>A0A367LEH9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HAD superfamily hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_0976</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEH9"/>
    <dbReference type="STRING" id="1330021.A0A367LEH9"/>
    <dbReference type="OrthoDB" id="426235at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01427">
        <property type="entry name" value="HAD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01549">
        <property type="entry name" value="HAD-SF-IA-v1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43885">
        <property type="entry name" value="HALOACID DEHALOGENASE-LIKE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43885:SF1">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13290)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI12834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="27615" checksum="FD7CDA21699A7F59" modified="2018-11-07" version="1">MIPPAGFKRFAPLTAAAASASASASASASASTSAPPPAPTLRGIIFDMDGTLCQPQTYMFAEMRTALGIASSVDILHHIEGLDPHRQPAAADAIRAIESRAMLLQTPQPGLSALMSYLDSRRIPKAICTRNFHLPVQNLLSKFLAGSSFDPIITRDFRPPKPHPAGLLHIAASWGLHDDAGLPDASNLIMVGDSIDDMTAGRMAGAATVLLANDVNRHLVRHQHTDLAIERLDDLITILDRGFQSAEPNNDPSRHSLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LER0</accession>
    <name>A0A367LER0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_1346</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN7/EIF3M family. CSN7 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LER0"/>
    <dbReference type="STRING" id="1330021.A0A367LER0"/>
    <dbReference type="OrthoDB" id="10265275at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045237">
        <property type="entry name" value="COPS7/eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350:SF5">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22061">
        <property type="entry name" value="CSN7_HB_subdom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="218"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="218"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI12900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="268" mass="29769" checksum="818FFE7E08301698" modified="2018-11-07" version="1">MEQAKALTALEPFLALSKTATSPRAAADLIVQATSAPNTFVFAELLHTPQVQALAQSDAYRSHLQLLNIFSYGTYKDYLALASELPSLDDAQILKLRQLSLLTLARDRENLYYDRLQQALNISSARQLEDLVIKAVYQGLLSATLDPARQAVRVTSVAPLRDLRPGSIPELISALNKWSSRCTSTLGTIESNMATFRSSLATRAAEERAEEEKLRRFMAELREPDKSLESSRRGPGKRAMVDQAVTSAETMELDEPEEQTKRAGKRKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LES1</accession>
    <name>A0A367LES1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="14">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">L249_0582</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="14"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LES1"/>
    <dbReference type="STRING" id="1330021.A0A367LES1"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
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    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.150:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
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    </dbReference>
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        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
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        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="19">
        <location>
            <begin position="38"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="18">
        <location>
            <begin position="243"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="20">
        <location>
            <begin position="509"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="21">
        <location>
            <begin position="608"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="22">
        <location>
            <begin position="710"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="16">
        <location>
            <begin position="788"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="17">
        <location>
            <begin position="1162"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="RCI12917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1262" mass="142622" checksum="3F728DD3BD469BA8" modified="2018-11-07" version="1">MADYEDEYDYDNFAEEEEEGITPEDCWTVISSFFETKGLVSQQTDSFDEFTQTTIQDLVNEYSTITLDQPNPPSPPGVKIALRRYEIKFGTVMVSRPTISETDGTVTSLLPYECRDRNLTYASPLYINITKKVSAAIEKEVPLHEMDEAQQEEYARTGEHPTKLIWEQEESGEDEDSSKPADWKNMVFVGKLPIMVKSKICHLSRETDDNLFLVNECPYDQGGYFVINGSEKVLIAQERSAANIVQVFKKAQPSPYNYTAEIRSALEKGSRLISSLMLKLYGKGDSARGGFGQTIHTTLPFVKSDLPVAIVFRALGVVSDEDILNHICYDRKDSQMLEMLRPCIEEAFCVQDREVALDFIGKRGNRDQAGLGREKRVRVAKDILQKETLPHISQTEGSETRKAFFLGYMVHKLLQCALGRREPDDRDHFGKKRLDLAGPLLAKLFRGIVRRMNTELSNYLRRCVEGNRHFNLAVGIKPGTLSNGLKYSLATGNWGDQKKAASSTAGVSQVLNRYTFASTLSHLRRTNTPIGRDGKLAKPRQLHNTHWGLVCPAETPEGQACGLVKNLSLMCYVSVGSPSEPLIEFMINRGMEVVEEYEPLRYPHATKIFVNGVWVGVHQDPKHLVNQVLDTRRKSYLQFEVSLIREIRDQEFKIFSDAGRVMRPVFTVQQEDDPETGIEKGHLVLTKDMVNRLAKEQAEPPEDPSTKMGWEGLIRAGAVEYLDAEEEETSMICMTPEDLELYRLQKTGNPVDEDPGDDLNKRLKTKTNPTTHMYTHCEIHPSMILGICASIIPFPDHNQSPRNTYQSAMGKQAMGFFLTNYSRRMDTMSNILYYPQKPLATTRSMEFLKFRELPAGQNAIVAIACYSGYNQEDSVIMNQSSIDRGLFRSLFFRSYSDQEKKVGLNYTEVFEKPFHQSTLRMKHGTYDKLDDDGIVSPGVRVSGEDIIIGKTAPIDQESQDLGTRTSVHQRRDISTPLRSTENGIIDSVVVTVNADNVKYVKVRVRTTKIPQIGDKFASRHGQKGTIGVTYRQEDMPFTREGVTPDIIINPHAIPSRMTIAHLIECLLSKVSTLEGMEGDATPFTDVTVDSVSELLRKHGYQSRGFEIMYNGHTGRKLRAQVFFGPTYYQRLRHMVDDKIHARARGPVQIMTRQPVEGRARDGGLRFGEMERDCMIAHGAAAFLKERLFEVSDAFRVHICEICGLMTPIANLSKQSFECRPCKNKTKIAQVHIPYAAKLLFQELQAMNIAARMFTNRSGASLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFE7</accession>
    <name>A0A367LFE7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HbrB-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFE7"/>
    <dbReference type="STRING" id="1330021.A0A367LFE7"/>
    <dbReference type="OrthoDB" id="2290221at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013745">
        <property type="entry name" value="Bit61/PRR5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32428">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT BIT61-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32428:SF2">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT BIT61-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08539">
        <property type="entry name" value="HbrB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="715"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="841" mass="90112" checksum="1670DCDB38B58003" modified="2018-11-07" version="1">MQSGQHPPPPASSRLRAIGSLSSLTGSSSPSMKPNQSTGPTRPPSLRIDSSAGQDGNFAPSSAVNKTRGWDASPATPIYNQFATVQTSASASNLHQNFSRPAAPPQLTKPLVSPSLLKGHTRKLSATQGSFDSTLPSTTTPNLPHVGMSQPGQDSPPTSLTASQMAAKAAILSHQNTSHMRQRSQTVPFPGEPNEGSRRGSGSKVPVSPPMLSLTEASAPRDSGFAGAAGQLRDRMGFFPTSTSAANVVFPRSGPSSPREKPMSPPPVPPVPPEKPPSRLDKPKVKLFSRPVKIGTSKTDVKEKALPSPGKIGTALSALQRGNFSTASVADAPSQSLYSLHNNSSSATIRPADVPSEDKDKDKDRDKDREKKHHFLSRQKQKLKDDYHLPLSSASSNSRPTDPSAPSSLYNFNVPASPGPGSTAFVKAKKDKWLAERSESRLESEQGLGVQGDYWPGPGSLPQPATLYDGIDVAKLGLQSHVTLDDAWPYLKAKLLVIFEGEDLRLPVEDFNRVVQMHIQWCINKRSPGAILEDVGELLATGFASLDRTLRMTSEDHFLPALVELWLFTFTSILPYMQAVFLPLEFEVSGNGVLMTAEQAREFWGGVVTTSQPVDGAERAALAANLLDVRRLVLAMYRDTVILPRYDTLRSMFSRLSLEFLPSSFASVAMASPPNEPTLSTSPSESLASSSCIMAARPGTAMSLDPSVAGSSCSTSTLVGDTAGSDRGRSRAVSNVSFGSDGGASLLRPFTPSSVQVLSSVREQNVEDSKQVTDMVGRMLQCMSVLSGLGDADADANRRMVELCKMLKLNWLGRGRTGRNRRGIVGGKVRRDWARDEVRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFP6</accession>
    <name>A0A367LFP6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 6B homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_0126</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFP6"/>
    <dbReference type="STRING" id="1330021.A0A367LFP6"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000020">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000049">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000033">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="198"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI13238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="421" mass="47027" checksum="3A879A08BED7E620" modified="2018-11-07" version="1">MAEIAVENAMNHVPPHKKAAPSAIPTIDNFEGLPTDGGDDYASLKKLQRQLEYIQLQEEYIKDEQRSLKRELVRAQEEIKRIQSVPLVIGQFMEAIDQNTGIVQSSTGSNYVVRILSTLDREKLKPSSSVALHRHSNALVDILPPEADSSIAMLGADEKPDVTYADVGGLDMQKQEIREAVELPLTHFDLYKQIGIDPPRGVLLYGPPGTGKTMLVKAVANSTTASFIRVVGSEFVQKYLGEGPRMVRDVFRMARENSPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQTSNVKVIMATNRADTLDPALLRPGRLDRKIEFPSLRDRRERRLIFTTIASKMSLAPETDLDSLIVRNDPLSGAIIAAIMQEAGLRAVRKNRYNIIQTDLEDAYSSQVKGTSDDNKFEFYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFQ6</accession>
    <name>A0A367LFQ6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_1191</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFQ6"/>
    <dbReference type="OrthoDB" id="6418713at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="9">
        <location>
            <begin position="37"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI13264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="359" mass="38969" checksum="A399B9FE29A533CD" modified="2018-11-07" version="1" fragment="single">MDSAGFTNTNNQDSVRSSFLLSSFPHTLIDTRQAISLTCGHLVFTTAATQVLARTTPRLDSRHRLPLRRGTYVRAIVPIGIFYSGSLMLSNMSYLHLSVAFIQMLKAASPIATLLMSWAWGVADPSLGAFINIVVIVVGAALSSLGDVSFSLYGFSTQVGAIVFEAVRIVMIQHLLSDGGFHIQPLVGLYYYAPICAVFTFLFALKTEFALLDVDAIKSLGFGVLFLNAAIAFMVNVTSVLAIKRTSGLVMTLTGISKNVALIIVSAAIWHTYISPLQAAGYTITLIGLFQYSFGFENLAVYMPLTRGRRPLSFSNSNVLRKLASTVFVIGTVMITAAIIVFCADPSPRPWRPLHRLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFR8</accession>
    <name>A0A367LFR8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfatase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_1196</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFR8"/>
    <dbReference type="STRING" id="1330021.A0A367LFR8"/>
    <dbReference type="OrthoDB" id="103349at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052701">
        <property type="entry name" value="GAG_Ulvan_Degrading_Sulfatases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43751">
        <property type="entry name" value="SULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43751:SF3">
        <property type="entry name" value="SULFATASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="3">
        <location>
            <begin position="434"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1001"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1009"/>
            <end position="1020"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI13265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1087" mass="120596" checksum="A35AAFB1906BBB87" modified="2018-11-07" version="1">MIPRLLGPSQAGPSLSASIILFFFHRRALLPARYAFSVLTVAVLAAKLVHIYAHVDAMASGLLGYSMSFFSQDVLFLLLMRLFLDNISSISIRSLRLLAISVASFIISSTLFFASVSISFFVVTGTELRWRNVGVASDSAAWGMLLSGLFSCSVTAASIVVFAWLAQNPCAVVFGAVLNLIRWPLAFLLSKVSPRAAASCSSSSSPPTYHNIPQDDVEDASGEHKLLTVDDAPTPADEKRPSLCLHVSLAITLIIMAISSVARPVDSSLVFMSWTLPLIPFIDLLPSSPSLTRLVPSYGNEVNSDLENRTALAEAPAWPWLPQGKPLPGFTDWYDGKEHYRADKDPLRVSNLDSALLPELRHSLGNIKIRHVVLIKLESTRKDVFPIKKGGYIWETLAASHDNNTLPASAVDLFSSLTPNANYLTGDYDDGFSHTHRKARGGINANNVHTTSTYTLKSMAGTLCGLYPLVADFNREYETHVYQPCLAHIFNAFNEILKDSNAGGGGDDFNSYKWRSTFIQSVTGGYDKQDAEMPVLGYPDGFFVSKEYLHSDKAKFGKINESDTNYYGMSEEVLKDYVRDEFASAKKNNGRVFLSHLTSTTHHPFVLPEGENYLPLSDEKKLNDLSHYVNTIGFADRWLGQVMEMLDEQGVANETLLVLVGDHGLSLPENGGVTPYYNGHVGNFHVPLVLSHPLLPAIDVNDAAASLSILPTILDLLIETGSLSKTTKQAARDLMGNYEGQSLLRPQRQASWETGESNWLFTVMNPGRATIAVRDAHRPDWRLIMPVIDDVEWRFTNTAEDPHEKEPVISFSFSPLLEKIERKYGVEAAAWTETAAFKARWWVKENNKRWRFDAYQTKGHRAEKGVAGAGLANEYDATWKSYILVPCCASRRRGTGKRGFLFKAIDRLDQLDPRDGVELGTGHETVGRWFSASGPYAVGNDEFQYDCPLAETGLRTGGGGKGEPRTRVDVHSGFPPSGPGRNGGVWCGIWRPRTRITIPVGTCPGGYHEEEEEEEEEEEEGGGRRRKQMMKTQTESTMGRWKQFYSSAYVHMLLRDRERPPILSPSSSSYLVSQVFFFFFFLPVFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LG42</accession>
    <name>A0A367LG42_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ribonuclease T1</fullName>
            <ecNumber evidence="2">4.6.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_1220</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[RNA] containing guanosine + H2O = an [RNA fragment]-3'-guanosine-3'-phosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA fragment].</text>
            <dbReference type="EC" id="4.6.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonuclease N1/T1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.24" evidence="2"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LG42"/>
    <dbReference type="STRING" id="1330021.A0A367LG42"/>
    <dbReference type="OrthoDB" id="5425539at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046589">
        <property type="term" value="F:ribonuclease T1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00606">
        <property type="entry name" value="fungal_RNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.30">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000026">
        <property type="entry name" value="N1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016191">
        <property type="entry name" value="Ribonuclease/ribotoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42104">
        <property type="entry name" value="EXTRACELLULAR GUANYL-SPECIFIC RIBONUCLEASE RNTA (AFU_ORTHOLOGUE AFUA_4G03230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42104:SF1">
        <property type="entry name" value="EXTRACELLULAR GUANYL-SPECIFIC RIBONUCLEASE RNTA (AFU_ORTHOLOGUE AFUA_4G03230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00545">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53933">
        <property type="entry name" value="Microbial ribonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016958688" description="ribonuclease T1" evidence="9">
        <location>
            <begin position="19"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI13388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="124" mass="13307" checksum="DF7904B458B32DCD" modified="2018-11-07" version="1">MQLPVLALIIALTRAALGDTQCGNTLYSSSDVDAASDAACQYVRDEETAGSSTYPHRYNNFEGFRFRDFAGPFYEFPLLPSGRLYRGGRPGPDRVVITEDCEQAGQITHSGAGGNSFIGCSGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGP1</accession>
    <name>A0A367LGP1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Stress-associated endoplasmic reticulum protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_5472</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Interacts with target proteins during translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation and facilitate correct glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the RAMP4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGP1"/>
    <dbReference type="OrthoDB" id="16679at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010580">
        <property type="entry name" value="ER_stress-assoc"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06624">
        <property type="entry name" value="RAMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI13569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="68" mass="7860" checksum="53EBC6DE0B098723" modified="2018-11-07" version="1">MAQTLEQRRRNAKFAKEQEARMGLSEEQVKKRTEKTPKVPISMFWIALLAFVVFGGLLFEALARMFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LH49</accession>
    <name>A0A367LH49_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LH49"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="117" mass="13400" checksum="A31BB950CA9AC0FF" modified="2018-11-07" version="1">MLRYSFALPAAADPEGLFDYRLLRGGKDEGPALADLAAFFFLLPTAGELTADSTLFFFRPLQIRLRLRLRQTPSLLQFPYCFFFPSRTPSLARFFRLLFSYGGTRHGARRRKIRSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LI16</accession>
    <name>A0A367LI16_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_8010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI14068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LI16"/>
    <dbReference type="STRING" id="1330021.A0A367LI16"/>
    <dbReference type="OrthoDB" id="241990at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000263">
        <property type="entry name" value="Stress activated MAP kinase interacting protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031567">
        <property type="entry name" value="CRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008828">
        <property type="entry name" value="Sin1/Avo1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031313">
        <property type="entry name" value="Sin1_PH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13335">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT MAPKAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13335:SF1">
        <property type="entry name" value="TARGET OF RAPAMYCIN COMPLEX 2 SUBUNIT MAPKAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16978">
        <property type="entry name" value="CRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16979">
        <property type="entry name" value="SIN1_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRIM" evidence="3">
        <location>
            <begin position="328"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="SIN1-type PH" evidence="4">
        <location>
            <begin position="713"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="484"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="694"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="116"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="521"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="558"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="570"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI14068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="821" mass="89816" checksum="B2C7BCF08EBF4DFB" modified="2018-11-07" version="1">MSILQLDELVSYQLRTSYLDEIADGVGERLITVDETLLTSVPFKAAGWRPSSSHAKRTHSPPIPTAIASEYFQAPRQAGLTLEDAEEDGGMLTGGGADSAGPGLATKRRRRREQMMDDDSSDFSDDSEDESEQRAAQQIKFSKMPVRPRAGSSPIQTSQLAPRTPRRGSQSALETTRERLRRDTVTSSEVSSENELDAPVARAAPRTVRLQESIHEEPLSSGLERAGRVEDDDDDDDDDDDDDDSDEASDLSVDYVESIDSASILDGVENALKGSPTQPVVGTPPRNFMRRSTIRKSHAPPAKPLVLEALPPPRPLSTIRPQSVAQPQSLLSAAFRAKQHKPSVPFQQFAHFSGQGTQGSFNIRIYAPFSGTPDKPFEVPIRPRVHDGQGAERAVTVADLIGLSLYRYNEERREPAVPAEKRNINWWTLRMVEEGGEVDDDFPAFERTKQLAAFTTANNAGPRGGGRLRSNSTVTDDFALVPATAEEFEENKTLTPQEDVGGEGEETSSAEQPPPPPPPQQQQQQQQQQQQQVQQPLQQQQLQQSVLQHQQAPRPNPIVTTTYRPNTSLADAPQAPATAPSTTRGQQKFLRVHIMSADMAAGQLVTVDVTTATYLAEVLDLVCRKRQLDKANHVLKLPGSGAVVMIDRPVSSIGHVSDLELYRRRFATDGPLSMTGSPSSSSPKAMPLADGQLQRKKGPIAGPHPLAQEASSNKRYTVWRKQPMRLVGMSERILAIDGEYIHIVPASGGRAVHDGGGGKTTTVHFSNVIGCKVPRKHPTNVKLVIYKATESKRYDFEARGADEAAEIVAELKKGISPYREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIN8</accession>
    <name>A0A367LIN8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIN8"/>
    <dbReference type="STRING" id="1330021.A0A367LIN8"/>
    <dbReference type="OrthoDB" id="9975758at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="207" mass="23253" checksum="DF23CAD6A9982DB0" modified="2018-11-07" version="1">MSIQLNPPTRYSTSSPPSSSSGPSITWLTSTPWTVTHSTLSMWRTARNVRISYTALPPKNPGGRSRLDDLVEYEPVKTDGVRKTVEGVDTQASVENDAVEQQDGCASWDWRGKRWLSFVSSHWEVLGWGEEEMAGGGGVERWAVTWFAPTLFTKEGLDIYCDRREGLSEETYKSLREAFKALGVSKLVAMVDEHMRPVEIRLPWVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIZ3</accession>
    <name>A0A367LIZ3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIZ3"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="106" mass="12076" checksum="337A094120426F3D" modified="2018-11-07" version="1">MRADVMTHGDKSGVYGLSFFFCFCFCFFFSFVFCLVMFCFVAFKRAMAGPHRLCMSMTEEQGGKKKKGGKFVCIIFISSPSLDKFKSATEEEEDERVVGCYSCHDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJ43</accession>
    <name>A0A367LJ43_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L249_6142</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJ43"/>
    <dbReference type="STRING" id="1330021.A0A367LJ43"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17973">
        <property type="entry name" value="DEXHc_DHX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000324">
        <property type="entry name" value="pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000003">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044756">
        <property type="entry name" value="DHX15_DEXHc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF109">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="103"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="290"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="42"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00055599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCI14444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="775" mass="87610" checksum="46CAD166388CD1F6" modified="2018-11-07" version="1">MDSAGAKRANTEADQVSRKKTKMSQTMNPYLAHMYADDDEKSSVGGFGPLSGMSRHESTAEQATKAEDGAENPFSGRPHTQQYFRILESRRNLPVHKQRQEFLDKYHSSQILVFIGETGSGKTTQIPQYVLFDELPQQSGKLIACTQPRRVAAMSVAQRVADEMDVTLGEEVGYSIRFEDMTGPKTILKYMTDGMLLREAMHDHDMSRYACIILDEAHERTLSTDILMALLKQISVRRPDLKIIIMSATLDAQKFQKYFNDAPLLAVPGRTHPVEIFYTPEPEKDYVEAAIRTVLQIHASESDGDILLFLTGEDEIEDACRKIKVEAEEMTREVGAGPLVVYPLYGTLPPQMQQRIFDKAPAPTSKDGRAGRKCIVSTNIAETSLTIDGIVYVVDPGFSKQKIYNPRIRVESLLVSPISKASAQQRAGRAGRTKPGKCFRLYTEKAYKKELIEQTYPEILRSNLANTVLELKKLGVEDLVHFDLMDPPAPETMMRALEELNYLACLDDEGELTALGSLASEFPLDPALAVMLISSPEFYCSNEMLSITSLLSVPHIFVRPATNRQRADTMKAHFSHPDGDHLTLLNAYHAFKGQAASSADGGRNWCHEHFLSFRHLTSADNVRMQLKRIMETHGIELVSTPFEDKSYYINIRRALLAGFFMQVAKKESTGKVYRTIKDEQAVLLHPSTVLRTEYDWVVYNEFVLTSKQYIRTCTGIRPEWLLQYIRTCTGIRPEWLLEIAPIYYDLDTFEDSDVLRSLKRATVKKRRKEAMKAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJ57</accession>
    <name>A0A367LJ57_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="15">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">L249_6147</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.</text>
    </comment>
    <comment type="function">
        <text evidence="15">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of pre-60S ribosomal complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="15">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="15"/>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJ57"/>
    <dbReference type="STRING" id="1330021.A0A367LJ57"/>
    <dbReference type="OrthoDB" id="7396459at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17960">
        <property type="entry name" value="DEADc_DDX55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056330">
        <property type="entry name" value="CTT_SPB4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23681">
        <property type="entry name" value="CTT_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="19">
        <location>
            <begin position="299"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="17">
        <location>
            <begin position="347"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="18">
        <location>
            <begin position="587"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="840"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="14">
        <location>
            <begin position="299"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="869"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="881"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="892"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="20">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RCI14449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="938" mass="105083" checksum="40C33F47523989CA" modified="2018-11-07" version="1" fragment="single">VQDELADKTQRDSMIVENAFNDFDGCQRGNYIYHPAYGQLALTLLTMRWLLTKIFTESKANRIRLQILSDLHLEVGKQYSSFTFPATAPYLLLAGDVGRLIDYSEYLAFLQSLSGRYKTVLLVLGNHEFYGLDYESGLAQAQRLVREPALADAVVLLHRARWDDPDSSLTILGCTLWSDISQDRQAIVQARINDFSRISAWTVQKHNQTHADDLAWLRRQVDQLENDTENNDKRRLLVATHHAPCLERTSHPDHADNPWVSAFATDLLTDRGWDGVEVWVFGHTHYSTDFLLPSDSRAWTALTPPLAEWILEAVSSMGFAQMTPVQAATMPHLAGNKDVVMTPVQAATMPHLAGNKDVVAVTGSGKTLAYLIPAVQRLLRLDEPTKRHEVAAIIVSPTRELAAQIHSVLLSLLRFHPPSAELLPCLDSDEKRPGTSQPVVVPQLLVGGTTTPAQDLAFFLRHSPNLLIASPGRLVELLASPHVHCPQSSFDLLILDEADRLLDLGFKQHLQGILSRLPKQRRTGLFSASVGEAVTEIIRVGLRNPVKIEVRVRIKDGSLVQERKIPASLQMTYTIKPASQKLPALCRLLQQLPVTPQRSIVFLSSCAAVDYFQNVLPALLPPTLSLVPLHGKHPAKVRDKNFARFLSSVSPTMLLTTDLAARGLDIPQVDLVVQVDPPSDPKVFIHRSGRAGRAGRKGLAVVMLHPGREEDYVRFLDVRKTPVLPLDPDLDPDISPSDASAATQTIRSIVKSDRALHDKAQRAFVSWVRSHGAHHATSIFRVADLDWSDLAEAWGLLRLPKMPELRQWEGDRFLGLEINWHDLAYKDVARETARQAALLQEEGQEGEEGKQKTATRQLGKRKPSSESWSAKHEKDECRLLRREKRHRKREAQRRADMSSDDLARQSELQDLIDQVRRRNQASSSSGHHHEDEFQGFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJA3</accession>
    <name>A0A367LJA3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone chaperone RTT106/FACT complex subunit SPT16-like middle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_7014</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Histones H3 and H4 chaperone involved in the nucleosome formation and heterochromatin silencing. Required for the deposition of H3K56ac-carrying H3-H4 complex onto newly-replicated DNA. Plays a role in the transcriptional regulation of the cell-cycle dependent histone genes by creating a repressive structure at the core histone gene promoter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with histones H3 and H4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the RTT106 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJA3"/>
    <dbReference type="STRING" id="1330021.A0A367LJA3"/>
    <dbReference type="OrthoDB" id="75754at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050454">
        <property type="entry name" value="RTT106/SSRP1_HistChap/FACT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849:SF3">
        <property type="entry name" value="HISTONE CHAPERONE RTT106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="5">
        <location>
            <begin position="239"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="336"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="376"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="393"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="446"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00037550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI14504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="503" mass="55228" checksum="32FA4F7595183D92" modified="2018-11-07" version="1">MAASLDLRTIAAVFNSRPDIVERINKSADSPARIALFNDIAGHVYGQIHNSDEPAQKRRRVEQSQSNGSVTTGNAADEAVLLEVKEISVTAPLRKKLELCLTPSFLYARAPGSTVPFPGITYPWHDIEYAFFLPVPEKTQVQHNYVLFPRGACLPSKAAQQPQPEPLVFTVPSTAPKEGTIGGSEASAAASVADTYKSLFHWALGKRLKSAGNPIQIVSANPGKFHSVMRQPHRPNEKAVHVSAFRGSKDGYLFFLENGILWGFKKPLAFIPLDRVAAISYTNILQITFNIVVEVFLGEGEGSEEMEFSMLDQQDYGGIDNYIKLNRLQDRSMAEQRKGKLQLAENKRGAEDGENGVGGGALSELERAQVEAEQQLQDDEDDEEEDYHPGADGESEGSGDSSDDDEGDDDDDDDDDDDDDGVEGEGEGEGEGEEQEEEGEEEEEEIKPKEEEIKTRKKKQAEAKPKEPVVKKEATTVRRGWATVSRGVRGGDMDVDEKFDVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJD4</accession>
    <name>A0A367LJD4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_6589</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.20" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJD4"/>
    <dbReference type="STRING" id="1330021.A0A367LJD4"/>
    <dbReference type="OrthoDB" id="1334205at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06595">
        <property type="entry name" value="GH31_u1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF89">
        <property type="entry name" value="ALPHA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="5">
        <location>
            <begin position="183"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="6">
        <location>
            <begin position="498"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI14535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="786" mass="89197" checksum="43B614F1C4EFECA3" modified="2018-11-07" version="1">MAPPASPIVAGEHYRFTILTDGLLRYEWAPDGVFEDRPSFFAAARHASRPVPEYKVYETAEKLEIMTARFHLTYDKKEFTPYGLFVVVFGYTGTTWRYGETHEDLGGTVKTLDNINGRIPVGPGVNSRLGFAPLRDDSFLFTDDGFVAPRRPGPGRVDNYLFCYGHDYRKAVQALYSISGPQALLPRWALGNFWSRYYEYSAASYLELMDSFHQYRIPLSVAVIDMDWHLVDDERVRKYRGTGWTGYTWNRKLFPDPPAFIHQLHRRRLKLTLNDHPADGVQPYEDQYRAVAQKMHFDASLDKTIPFDIANRTFLDAYFDPLLQTLRNDGVDFWWVDWQQGTQSTLPGIDPLPMLNHFHYAKWTGSGRPMLLSRYAGPGAHRYPIGFSGDTVVSWESLDFQPEFTATASNIGFGHWSHDIGGHMLGSRDDHLTTRWVQFGVFSPVFRLHSTKNRWVCKEPWKLPQGPREVVVSFMQLRHRLIPYLHTMNARAADPLNGEPLIQPLYWDFPEREEAYMFRNEYWFGSQMLVAPITSPTSRESTHLGSTRAWLPPGRYVDFFLGAVYDGNRTIWLSRTLDKMPVFLREGAIVPLDGDLEPSNGGENPAKVEVVVVVGADGRFELLEERQGKESNSKPDWAKTPIVFDQAQGRVTIGPTEGGDGRAWTVRLLGYKDTKNSVKASIGDRSINPVVKTASNGLLVELGDVSAGSRATVQLGSNPQLAVNDPMALLDPILYDAEVSMRLKEYIDATFQLESKSARASQMEALEMEDGLRRLITEMLFADSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJI3</accession>
    <name>A0A367LJI3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">3-isopropylmalate dehydrogenase</fullName>
            <ecNumber evidence="4 14">1.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L249_6629</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(2R,3S)-3-isopropylmalate + NAD(+) = 4-methyl-2-oxopentanoate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:32271"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17865"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.85"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="14">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="14">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 14">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.85" evidence="4 14"/>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJI3"/>
    <dbReference type="STRING" id="1330021.A0A367LJI3"/>
    <dbReference type="OrthoDB" id="419183at2759"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00072"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003862">
        <property type="term" value="F:3-isopropylmalate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000006">
        <property type="entry name" value="3-isopropylmalate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004429">
        <property type="entry name" value="Isopropylmalate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00169">
        <property type="entry name" value="leuB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42979:SF1">
        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12 14" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="5 14" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="7 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0520">NAD</keyword>
    <keyword evidence="9 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="16">
        <location>
            <begin position="648"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="108"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="355"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="499"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="365"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="379"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="514"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="525"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCI14595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="984" mass="105172" checksum="ED4FFD2FE2B15B1E" modified="2018-11-07" version="1">MTDSSIPSFGDPKAQPQTPKQTTSVAFPSPIFDTPKPYQGSFAEPGGLTPRFAEEYSVFNSTPGNLRGSQGPFADFVPPPPYSRGHKRLLSADGSLVDIPPHASHPLSANLDKFDLPLSPPAPTPSSSSSSSSIAVPGQLSPNLARRTSLKKSRKQSDADQQLQVLSPPPSSNKGGRKLAPKLDMLTNQAFCHQPDPVEHDIMTGHPADLFGYPLSAPASASSNFWDPSVPLPMDLEFNAHPAAAGVMHPPSHRQTESFDWNADITLFQDMPAPPPQQLASQESAQPMPRQERVIALKPPNPVSLEDPFGIMNPGDAVDPGLLVSRPHTSALDCGFGTWSRSRLAEGFAPSFGGDAMGGGELRRANSSQGPSRSSARLTTTTTTTTTTTTTGRPSAVGPPVKPVARPGLGRSCSENQGRRAAGRKKCPAPPVEGLRFGPETNLVGTWHAVPTGYWPASRGSPPKTVPRMMSLASIPETSPQRRPRTSVRLTIDSRGRARAETTVIDASSREWDSTDDESTDDEPIIIPSRNSSSNASYALPDPCKPVGSIFHTSCRSVRSNSADSEAETVVNHGQRKGGDAMRELRRVIEDRQKRSRRMAGGRPRGLLSTTATATNMANFPGGIISPTSLTGSSHGGNGVRCVCDDTSADEADGLMLQCMWRERKRDRHRGITVVDGFLSDVSAADAIVLGAIGGPEWGTGAVRPEQGILRLRKELGTYGNLRPCFFPSPSLVDASPLKADVCRGTDLVIVRELTGGLYFGRRKEDDDGSGEAFDVEPYSRPEIERVARLAGFLARRRGDSVVWSLDKANVLATSRLWRKVMAETFEREFSDLKVEHQLIDSAAMMLVKSPCKLNGVVVMNNLFGDIISDQVSAIPGSIGLLPSASIGGIPDGKTRCNGIYEPIHGSAPDISGKGIVNPIGMILSIAMMLRYSLNLPSEANAVEAAVRDALDSGLRTQDLGGKAGTKEAGDDVVNRLVSVLKKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LK07</accession>
    <name>A0A367LK07_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_6620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LK07"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="120" mass="13499" checksum="92277D09999BF2A2" modified="2018-11-07" version="1" fragment="single">MANKEEVVYPYSSSRCLSYLEKGIRALMAASAGRRAAFQLTAYMRCLPYLELQAAGYSCRKHTAQGPETRFLLHRYLVVADARLIFLCAMAKARKRRYMPRLQVSECTFALAPPPLAGFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LK97</accession>
    <name>A0A367LK97_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_6391</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat WDR3/UTP12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LK97"/>
    <dbReference type="STRING" id="1330021.A0A367LK97"/>
    <dbReference type="OrthoDB" id="407922at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01725">
        <property type="entry name" value="LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000053">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000157">
        <property type="entry name" value="WD repeat domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000178">
        <property type="entry name" value="WD repeat domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051570">
        <property type="entry name" value="TBC1_cilium_biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016654">
        <property type="entry name" value="U6_snRNA_Lsm2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN 3 WDR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19853:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25173">
        <property type="entry name" value="Beta-prop_WDR3_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25172">
        <property type="entry name" value="Beta-prop_WDR3_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="104"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="420"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="501"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="600"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="642"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="689"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="domain" description="Sm" evidence="8">
        <location>
            <begin position="933"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="315"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="745"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI14820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1026" mass="114160" checksum="F25C418D615EAD52" modified="2018-11-07" version="1">MVKSYLKYEHAKSFGVVVTGTSNIVWASTDRTGAGRAVVPANEQVLCWDIKKGELLGSWRDERCAAPVTVVAQSKTDKDVFAVGYGDGSIRLWDSKIATVIVNFNGHKSAVTKLAFDRSGVRLASGSKDTDVIVWDLVAEVGLYKLRGHKDEVTGLHFVEPDGHANDGEGSRAMVRDSGNASEGFLLTSGKDSLIKLWDLSTRHCVETHIAQTNGECWALGMSPDFSGCVTAGNDGEMKVWWLDVDALTADSRGADASPTTRYLSDRGTLHRQSKDRATEVVFHPQRDYFAVHGSEKGVDIWRIKTQAEIKKTLARKRKRRREKEKDGKQADEAMADVNGEDGTNAGIGDIFVQYVIVRTGGKVRSVDWALGGGAQKDVRLLVATTNNQLEYYSIPLKDKDDTKKKQVIPDYAKTLSVELPGHRTDIRALALSSDDKMLASSANGSTKIWNVKTQACIRTFDCGYSLCCAFLPGDKVVVVGTKSGELQLFDVASSSLVDSVQAHEGAIWSLHVHPDGRSVVTGSADKSAKFWDFKIVQEEILGTKRTRPKLKVVQSRMLKVSDDVLSLRFSPDARLLAVSLLDNTVKVFFVDTLKLYLNLYGHKLPVLSMDISYDSKLIVTTSADKNIRIWGLDFGDCHKALFGHQDSILQVAFVPHNSDGNGHHFFSSSKDRTIRYWDGDKFEQIQRLDGHHGEVWAMAISRSGNFVVSAGHDKCIRVWDESDEQLFLEEERDKELEELYESTLTKSLEKEEPDLEGDGGELGAASKQTTETLMAGERIQEALEMGMADLNLLKEYDEAKLSDAKAPAPQRDAVLVALGNISAEEHLMSVLQRIKASALHDALLVLPFASVPILFTFLEIFARRSMNLPLTCRILFFMIKTHHKQIVASRTMRTMMEKIRSNLRAALRRQKDEMGVNMAALKVVGMLIRDRSVRDFFKTLIDHEVTVELKNDIQLRGTLKSVDQYLNIKLDDISVVEEIKYPHLSSVKNVFIRGSVVRYVHLPAASVDTQLLEDATRRAQRAKPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKS4</accession>
    <name>A0A367LKS4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKS4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="59" mass="6971" checksum="4D3DD0FFF41C899B" modified="2018-11-07" version="1">MPSIITTIPTLKTLNYYLISIIYYRILLLVARRANPRQYLRLPLPYCYLAKADLLCRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLH5</accession>
    <name>A0A367LLH5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_6482</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLH5"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI15286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="69" mass="7674" checksum="B431C45EF87339EA" modified="2018-11-07" version="1">MCFSFQNRVKIPGDMRSGCRPDAAGVVNDGEEELYRDMRRVLVSLGPTTDEWIEINAHPAFGMASNSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLP6</accession>
    <name>A0A367LLP6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methyltransferase small domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_6386</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic/archaeal PrmC-related family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLP6"/>
    <dbReference type="STRING" id="1330021.A0A367LLP6"/>
    <dbReference type="OrthoDB" id="406152at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035657">
        <property type="term" value="C:eRF1 methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052190">
        <property type="entry name" value="Euk-Arch_PrmC-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875:SF1">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI15320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="39109" checksum="04F549F36BADC605" modified="2018-11-07" version="1">MCTVTFFRHRDCKHMWATVTEPCGPGMGFYTCRSFEDTGVTKARPPVYRTRGRSCPRCGTGEAVDGNVVRLVERMGWGVKIGVGPDGDDWGVDLRCVMIGRKQGMLPTPDTSHVPYERVYEPSEDSFLLLDTLSSEAQRLFLRNQLSSSSHHPRLVVEVGTGSGVVLAFVHAHAEAILGSRHVFTSGVDVSAVACRATVATVNKAHDDDDVGDDDGNGRGCYLGACVADLVSPWRNGSVDLLIFNPPYVPTPSLPAPPNGGAQETQKPSFENDSHLLELAYAGGRDGMQTTDRLIDDLPRVLSPAGCAYIILCAQNKPPLVMERIRAFGSTWRAEAVASSGKTAGWEKLQVVRVWREPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LM40</accession>
    <name>A0A367LM40_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_3574</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LM40"/>
    <dbReference type="STRING" id="1330021.A0A367LM40"/>
    <dbReference type="OrthoDB" id="185175at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF125">
        <property type="entry name" value="GTPASE ACTIVATOR (BEM2), PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04450)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="497"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="135"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="691"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="188"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="225"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="257"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="305"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="436"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="713"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="723"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="733"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="747"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="763"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI15481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="790" mass="86576" checksum="41820A370FC1DBB7" modified="2018-11-07" version="1">MADGAVDARHNSPLSSPSVLLASLFHCPDPDCADGLILAVRPLRRRPRASPPQKRHFSNNHQLRDAPIDGPSSQEPLTSSAVSLLVSGRPGSSLFSLVEAISLLADSRFDSLAFLALNRPDMTRKLIPQPLVLAEAPSSADRVPDVEPAPPGSASRIASPVASQSPASSPLANKTKEAKSSTPPIINDDDKPSQEPKVSIDEQHKASPDKPKPSLDDAPPKQRRPASPALPSPSAGASPKGTKQRQKPSKAGFFHFNKSSKGSNQLPVTSRHQHQASREQLTSSGSDGVASSKRRDSPYAHDSLQKLSTPQPSRSELSLSSVGDHDTASTPPHGKKSRSKPFALLGRTKSVRDSREQGSITDPSVAGGVASKIDLVDSASQGSASDRLLREMSNSTVRNRSQDRTPSRDAKENHPSRDRDRRPPVSSQKENGGGSTFLSGLRSSSTRAADMISKGLFGKGPRNSGAEKEPVVDDEHYALKVIVLPLVEQTRLTRISKRLEHSRDKTEFWMPAFPWRAIDYLNYKGCDVEGLYRVPGSGPQVKKWQRKFDEQYDVNLFEEDDLYDINIIGSMLKAWLRELPDELFPKEAQDRISRECAGSTEVPQMLIDELSNLSPFNYYLLFAITCHLSLLLAHSDKNKMDFRNLCICFQPCMKIDAFCFKFLVCDWRDCWKGCKNEAKFIEEEYGLFEQPLPRGVSEPQQPSKEEEQEERPAVQAAAAAAESTSSKPTSSNGRKKTRSKKHDHSISQSNASVRSNGSSKSGSHSDRNAKDGLQDMRPLSPIKPLSPLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMH3</accession>
    <name>A0A367LMH3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_3423</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMH3"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI15609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="90" mass="9975" checksum="79E0E958F8C7F4E7" modified="2018-11-07" version="1">MGEAGDDEETQGGRDLFVAHVRGEEELIKGLTTYTHPPRIEIGDGCPWNEMIYRVFFRYSPTESRAALNGHPSAVLSLFSPALVSTRLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMJ0</accession>
    <name>A0A367LMJ0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_3432</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMJ0"/>
    <dbReference type="STRING" id="1330021.A0A367LMJ0"/>
    <dbReference type="OrthoDB" id="3830579at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI15610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="24205" checksum="71C00D7293097DCD" modified="2018-11-07" version="1">MASIIELITVTFKPDLQPSPGHPPSSFVSSVCDQIGRVPGVVALHHGGVQERPSDWMLAVRWRSPAHLDGFLASAERTAWLARLHAVSKRDVIRRLSLAGRPVDALSAPCTEVFFALGTDGDFVHGRLKPFVEALEAEAMHGFHASAWGPLELVACHGDEQQPPSSDASAAAAMLIGWDSKEAHLAHRGDGKAIDRHIQIVRDGRKAVEVCHVKMTVSMAPNQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMM9</accession>
    <name>A0A367LMM9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_3387</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMM9"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI15694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="68" mass="7317" checksum="28FEFA42CF96B160" modified="2018-11-07" version="1" fragment="single">MVGGLGLPPARLIPDQARQGDGAVHFRPVVTRGGPKMAKARFGRLRQIVTTQSINQSPLSYTPVLQHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LN73</accession>
    <name>A0A367LN73_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_3004</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LN73"/>
    <dbReference type="STRING" id="1330021.A0A367LN73"/>
    <dbReference type="OrthoDB" id="3196451at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060237">
        <property type="term" value="P:regulation of fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04396">
        <property type="entry name" value="RhoGAP_fSAC7_BAG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051025">
        <property type="entry name" value="RhoGAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228:SF25">
        <property type="entry name" value="F-BAR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15228">
        <property type="entry name" value="SPERMATHECAL PHYSIOLOGY VARIANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="63"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="285"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="292"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="327"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="343"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="405"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="480"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="532"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="557"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="671"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="687"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="707"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="733"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="774"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="800"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="813"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI15896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="829" mass="88857" checksum="1A094253EB69D23F" modified="2018-11-07" version="1">MSSAIPPSNRTSQAPSSPPNRRDLKSWWKNFKLPSKHQDSAPVAKAPGIFGVPLRQSITYANVAISLIDERGQSYIYGYVPIVVAKCGVYLKEKATGVEGIFRLSGSEKRIKELKSIFDSPDRYGKGLIWEGYTVHDAANVLRRYLNDLPEPVVPLDLYEKFRDPLRGATKLAVGDIEGPQFVDNFDEKAAIARYQKLITELPPLNRQLLLYILDLLAVFAAKADENRMNSQNLAAIFQPGMLSHPTHAMAPEEYRLNQCVLIFLIENQDHFLIGMQGTAADEKTMKEVASGTPTGPQTPNLNVVGPSLDRSSSNASAGATSVRRDGKIRRNRSVSSRHSRQEGSATPNSPSLATTPTGGLGRSNTVPSKKSPALGGAKLKKNDPAGHQSPVHVEPMTPVRPPQANRSSPPTATRAGSNLPGVLTASSGVSQERLLDASPESPGRERNLPSLFQRSPPDGGEKRQPNKLKKKRVAGGLNASAQSSSASLVHSSATSPTVEATHPVESMEPMAEPLSQPLPAPSSRQAQVDGTRGEAKRAPEPEQAAQKLPQALERPSQPTARASHATANTSLHPEDPRGPRSPPISVHSSSFNEGSDLDLGFDDQPTPMAEISDREKKRRWRLSRSRKDDNGGSSSSAATPPQPAIGSNDKAEISNTSIGSGASKPRDSGTNDSSEPTTVASTEGHTAGHETTKEDAKGPIGWIRSKYREAKESAEHRRNKSPSAERQASRGKSVDLKRERLDEKPQDKEAAAAPPPPPPHKERPASSPKATAGDTTSAETPSATVPPKAEAPASTQEKAIAEEARAEETQGEQKTSSATDTEAPSTRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LND6</accession>
    <name>A0A367LND6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_2035</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LND6"/>
    <dbReference type="STRING" id="1330021.A0A367LND6"/>
    <dbReference type="OrthoDB" id="5086884at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF11">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="488"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="56"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="534"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="536"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI15928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="562" mass="61520" checksum="F3C68E79E733B648" modified="2018-11-07" version="1">MDKMQLEKVVDIRGQKLQSDDQAATAELEPESEWSEVNRRLGWQRPAEFKSTWIEFCFVLSSVGALSMADFIIDGFPVILPALVEPFNIPSGSQIWPSSVVTMVAGSFLFPLGRLTDMYGGYYIFNGGLVWFTLWTLAAGFANSFVFLVFCRAMQGLGLSAFLPAGIALLGRFYRPGPRKNLIFALYGASCPLGLFGGMLTAGLAQQVFDQWRWFFWIGGAATGLCCVGTVINSPRDVVPADGRTGQRVTMDWPGTLTTVPGFMLVLYAAAKGTNSDNGFASPHVLISLLLGLAFLALAVYVEGKVESPMIPADIFQVKYMKPMLLYLLFSWGVYSMYQFYTNFYIQIVMGKSSLTTALWYAPWAAAGLLLSTLGGVVLDRIPACWLLIPSSISTIMAVLLFALMPTDPNYWAWIFPAMIFEAASADILWTVSNVFLTTSLPRHHQGLAGAIISMTLFMGDALFLAVGDVVEERLAQAGADANTQYKGVFWIAVVIGVVAILINAFIRIPRATAELTSEEKDDMMIDRVSWRRESSVSVTDSETVLGSEAEGLLGEPSEESL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNX2</accession>
    <name>A0A367LNX2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_1836</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNX2"/>
    <dbReference type="STRING" id="1330021.A0A367LNX2"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF54">
        <property type="entry name" value="FAMILY OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G13850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="3">
        <location>
            <begin position="67"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI16087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="393" mass="44191" checksum="DF161AA2B4FE14E6" modified="2018-11-07" version="1">MSATQFTAPEAVEPGQLRPMTGPLDWSGQDFENEESYTYTFDFQDVEEIHNSLASFLSLRLDRRQVSSSNFPLPRLGRRLFQAAEAIHRGHGFVVFRGLDPSLHSTEENVIIYLGLASHVADRRGQQDKDGNVLSHITSSKLWDAPMEKRHGIHSNEALPFHTDMGCDILALHARQSAISGGCTFLSSAWKVFNHLIRQEPDTAATLLASDWPVQISGGKSHHYLGPVFAVHEGRLLVNMDPHRLGPPTTADEQEHDDESQDDIPALTDRQRRALEKVSEIAELTELQLELQSGDFLFLNNWALLHRRQAYRQDEDSPSRHLVRLWLRNSTLGWSIPDLMLPPWRAAFEEGSGVEMMYPLYPPDTYVVPRYTTGSAAFVIDDGVWSVLSTAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPE5</accession>
    <name>A0A367LPE5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_3180</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPE5"/>
    <dbReference type="STRING" id="1330021.A0A367LPE5"/>
    <dbReference type="OrthoDB" id="4917606at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050475">
        <property type="entry name" value="Prenyltransferase_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42723">
        <property type="entry name" value="CHLOROPHYLL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42723:SF1">
        <property type="entry name" value="CHLOROPHYLL SYNTHASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI16261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="599" mass="66804" checksum="50297E8EA6A4F801" modified="2018-11-07" version="1">MLPDDNKPLFQPLLIYIRLIHLRKKRGEGYEKIGVKSSQLEWQTVDRQLECVQSSSLVDMNAYRLSPVGIRYTYTRCRILILLILTLSFLYKLVSTAIYRFSRPAAQMPITLMREIDLFVCFSWRDWINAVVSTWLFSLGALKDVSSMKDKALNNLGVLIWVTCCMYSFNLFSQSFSLDEDLINKPDRPIPSGKISAEEALIRSAAIWLFLFAVAVTHPQVMTETIVWFLLTYLLGATKPGGHWFGKNTVAMSFGAWAFFSAARKLMAPARAESTRHAVILSIWAGLTAHIQDFRDQRGDRKVGRKTLPLSYGDGPARLIVASLLLPAAYAIAYELDLARNAPLLLGGAHAWLSYRVLACRGVDSDTSTYTVSGRMGILTLISSLVSLGIVSVSNPVEARIKGGAILGYHSLWNISTAVQSITYQSHIDHPVSLFPGSAETINITIRASRNGVMLAQFDWAYLSTSVQTWNPFEDITSLTSHDSTKLPSTYTSRHIDLYSKNISPKMVRSVILLLGLPMLAYCATIPNGTETSSHVKRGGECRTYQDCPPCGFYQRCCLPVLGGGFCQCGTSGRENQCNKHIYVLYQCPHRRTLINLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPQ6</accession>
    <name>A0A367LPQ6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_3124</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPQ6"/>
    <dbReference type="STRING" id="1330021.A0A367LPQ6"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI16425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="97" mass="11144" checksum="0234C40DBC39E9C9" modified="2018-11-07" version="1" fragment="single">KIRTDKATFRDKEDRIGFLFRSLKGKARKTLETRLLTKTKDDSLSYEDFYGYVKDSAVKRLDAELVLPNNLPALAKYSLSILLPKTPLLNRQIDLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPS2</accession>
    <name>A0A367LPS2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_1980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPS2"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI16409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="81" mass="9284" checksum="826849E4728AF09A" modified="2018-11-07" version="1">MYLVIMKCLTKLYSIYLPLGLGDLNRISALCLTKLYSIYLPLGLGELNRISALYKEKYLYVSLERCVSPFGLDYGFNPARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPU0</accession>
    <name>A0A367LPU0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1763-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_2297</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPU0"/>
    <dbReference type="STRING" id="1330021.A0A367LPU0"/>
    <dbReference type="OrthoDB" id="4392610at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI16438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="132" mass="15188" checksum="312622E0E785F7E0" modified="2018-11-07" version="1">MTTSSIDVIHAYRHLYRSLLQAVQHAAPARYAGRDLLREAFRARGATLSPVGVKRTLWFLQAAAREAGLEHKILKNLLRVRTVQFASTSDWRKRFQDSQFKKDPMQEERAAAERHYQMTIAMLNSSMGLCLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LR91</accession>
    <name>A0A367LR91_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Multifunctional tryptophan biosynthesis protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="16">Anthranilate synthase component 2</fullName>
                <shortName evidence="16">AS</shortName>
                <ecNumber evidence="16">4.1.3.27</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="16">Anthranilate synthase, glutamine amidotransferase component</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">Indole-3-glycerol phosphate synthase</fullName>
                <shortName evidence="16">IGPS</shortName>
                <ecNumber evidence="16">4.1.1.48</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="16">N-(5'-phosphoribosyl)anthranilate isomerase</fullName>
                <shortName evidence="16">PRAI</shortName>
                <ecNumber evidence="16">5.3.1.24</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="20" type="ORF">L249_2986</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 16">Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 16">
            <text>1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H(+) = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:23476"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="EC" id="4.1.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:21540"/>
            <dbReference type="ChEBI" id="CHEBI:18277"/>
            <dbReference type="ChEBI" id="CHEBI:58613"/>
            <dbReference type="EC" id="5.3.1.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21732"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16567"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="4.1.3.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 16">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.27" evidence="16"/>
    <dbReference type="EC" id="4.1.1.48" evidence="16"/>
    <dbReference type="EC" id="5.3.1.24" evidence="16"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LR91"/>
    <dbReference type="STRING" id="1330021.A0A367LR91"/>
    <dbReference type="OrthoDB" id="524799at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00040"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004049">
        <property type="term" value="F:anthranilate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004425">
        <property type="term" value="F:indole-3-glycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004640">
        <property type="term" value="F:phosphoribosylanthranilate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000162">
        <property type="term" value="P:L-tryptophan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00331">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00405">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000136">
        <property type="entry name" value="Multifunctional tryptophan biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00135">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016302">
        <property type="entry name" value="Anthranilate_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045186">
        <property type="entry name" value="Indole-3-glycerol_P_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013798">
        <property type="entry name" value="Indole-3-glycerol_P_synth_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001468">
        <property type="entry name" value="Indole-3-GlycerolPSynthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001240">
        <property type="entry name" value="PRAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00566">
        <property type="entry name" value="trpG_papA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854:SF2">
        <property type="entry name" value="INDOLE-3-GLYCEROL-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22854">
        <property type="entry name" value="TRYPTOPHAN BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00218">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00697">
        <property type="entry name" value="PRAI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001382">
        <property type="entry name" value="TrpG-trpC-trpF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00097">
        <property type="entry name" value="ANTSNTHASEII"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00614">
        <property type="entry name" value="IGPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11 16" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8 16" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="12 16" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13 16" id="KW-0456">Lyase</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 16" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="17">
        <location>
            <begin position="43"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase" evidence="17">
        <location>
            <begin position="105"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="Indole-3-glycerol phosphate synthase" evidence="18">
        <location>
            <begin position="250"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="N-(5'phosphoribosyl) anthranilate isomerase (PRAI)" evidence="19">
        <location>
            <begin position="571"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR001382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RCI16939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="761" mass="82435" checksum="74A6387D11EAC24E" modified="2018-11-07" version="1">MHQRKLDAPGTAHILDGAVQMPTFSRRDPDPSPPVPTASNLIVIDNYDSFTWNIYQYLVLEGATVHVFRNDQITLKELIEKNPTQLVISPASLVGPSPGFAPLTLGRQCIFDVYGGDVNSAGEWLHGKTSPLTHDSRGVFAGLEQNLQVTRYHSLAGTHVTLPECLEITSRVAKADGSPSIIQGVRHKQLTVEGVQFHPESILTSQGRKMIRNFLHMRGGTWEENAKLQKMAPLNASPTVEVKAKGNNILQRIYASRKAAVAIQKEIPSQRMTDMQAAYKLNAAPPLVPLVGRLRQSPFDVALMAEIKRASPSKGVFALDMDAPTQARKYALAGASVISVLTEPEWFKGSIEDLRSVRQVLNAMPNRPAILRKEFIFDEYQILEARLAGADTVLLIVKMLEAELLKRLYEYSLSLGMEPLVEVQNAQEMKTAVQIGSKVIGVNNRNLESFEVDLETTGRLRSMVPEGTLLCALSGINSHDDVLMNSKDGVNAVLVGEAIMRAPDAGVFISELCSGSKRAIKTQPGAPLYVKICGTRSVEAAQEAVKSGADFVGICLVPSAKRCISQETALAISDAVHSYRGTSSTEGQEQMSSTGATDYFAATEWRLKSCRPRLVGIFQNQPLGEVLEMQRTYKLDVVQLHGDEPIEWASIIPVPVIRCFKPGQVGIGLRGYHAIALLDSGSGSGKLLDVSSVRAALERDADLRVFLAGGLNPDNVAAAVAALGEFSDRVVGVDVSSGVEDDGKQSLAKVAAFVKAAKGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRD9</accession>
    <name>A0A367LRD9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamate pyruvate transaminase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutamic--alanine transaminase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glutamic--pyruvic transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_2695</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRD9"/>
    <dbReference type="STRING" id="1330021.A0A367LRD9"/>
    <dbReference type="OrthoDB" id="1732682at2759"/>
    <dbReference type="UniPathway" id="UPA00528">
        <property type="reaction ID" value="UER00586"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042853">
        <property type="term" value="P:L-alanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1970:FF:000001">
        <property type="entry name" value="Alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000012">
        <property type="entry name" value="alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000010">
        <property type="entry name" value="Alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045088">
        <property type="entry name" value="ALAT1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11751">
        <property type="entry name" value="ALANINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11751:SF29">
        <property type="entry name" value="ALANINE TRANSAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="10">
        <location>
            <begin position="147"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00077894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00078532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00080525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI16957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="523" mass="56874" checksum="B210BC35FB9F4977" modified="2018-11-07" version="1">MAAAAAAAAAATTATTATTRRLSATAAAWAWTASGAARHQSTMRLTVDTINPNVRRAQYAVRGELAVKSEEFRARLAKSGGDSGLPFEQVVSANIGNPQQLDQKPITFFRQVCSLLENPELLKKRDVLINSLGYKPDVLDRAQWLLRQVGSVGAYSASNGVPAIRESVAAFLERRDGFPADPAHIFLSAGASSGVNTLLNVICADKSTGILVPIPQYPLYTATLSLLNATCVPYNLDESQAWGTDMGTIEAAYDAAKADGVDVRCIVIINPGNPTGASLPEDHVRAVLDFASRERLVVMADEVYQTNVFVGHFHSFKRVLRTMQRESPGRYDDVELASLHSISKGMVGECGHRGGYFELVGFDPDVEAEIYKFVSIMLCAPVIGQCLVELMVNPPKPGDASYELYDREYRAIYDGLRLRARALHKAFSQMEGVECAEPQGAMYLFPTIRLPPRAVEAAKAEGRSADEFYCMRMLEATGICVIPGSGFGQADGSLHFRTTFLAPGTEWVGRIVDFHKGFMAKYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRR0</accession>
    <name>A0A367LRR0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Farnesyl diphosphate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_2106</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRR0"/>
    <dbReference type="STRING" id="1330021.A0A367LRR0"/>
    <dbReference type="OrthoDB" id="10257492at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:(2E,6E)-farnesyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004161">
        <property type="term" value="F:dimethylallyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045337">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.600.10:FF:000006">
        <property type="entry name" value="Farnesyl pyrophosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039702">
        <property type="entry name" value="FPS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525:SF0">
        <property type="entry name" value="FARNESYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525">
        <property type="entry name" value="FARNESYL-PYROPHOSPHATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI17134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="40012" checksum="84D0DB4F6B1C554A" modified="2018-11-07" version="1">MAKKTTREEFEAVFPTLVDVILQHVQTYNLPSDAFQWFKQNLEVNTLGGKCNRGMSVPDSVSILLDAPLDEKQFLQAAALGWSTELLQAFFLVADDIMDNSITRRDKPCWYRRPGVGMIAINDSYLLQSSIYILLKAFFRSHPSYLGFLELFHETTLQTEIGQLKDLLTAPEIVDLDSFSMDKCRFIVVHKTAYYSFYLPVALALHMLNLATPKNLEQAQKILIPIGEYFQFQDDYLDNFGLPEHIGKIGTDIRDNKCSWLANKALELVTPEQRKILDENYGRKDDAKELVVKRLYDELKLKDHWEAYEEKRVSELRLMISQVDESEGLKKEVFTAFLNKIYKRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRS5</accession>
    <name>A0A367LRS5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vegetative cell wall protein gp1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRS5"/>
    <dbReference type="STRING" id="1330021.A0A367LRS5"/>
    <dbReference type="OrthoDB" id="5398854at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI17118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="427" mass="48284" checksum="6E3624BEE4888B84" modified="2018-11-07" version="1">MNYPSPRTPGTTPMHEWEYSRMPSATPTPSPRANWFDPSTPRRPATRAAAHHSRASSYQQPHSPWPYMESPRYNSYGTYCTVDVSVKDFSSSRRPPVWVSPPPSPCRGRASTPYAESDEDEFFEAMGRTYMLPAQHSRRRHGAWSTDRPDYQQSAAAYYADPACARAAQYYEPVRPQAHHHHHHHHHHHNQHPHHHQQQQQQHYRPPTSHARRGSTTVPQRSATVKPTTTHGPPPRPKPPAPSPTKATEADARRHKIPPGYSLKNWDAAEEPILLLGSVFDANSLGKWIYDWTVYHEGAAAPIADMAGELWLLLIQLSDHVKQAESKVGVVRSAENRETIQDFVDAGERLMDKLRGLLKACEAPMLKAARGKKQSSSLGKNSGVEFVETLFGRDRELAKTEKFMTSLRLFNLRFEANCSEILDKPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LS15</accession>
    <name>A0A367LS15_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">NADH-ubiquinone oxidoreductase 78 kDa subunit, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Selenoprotein O</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">L249_2366</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SELO family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the complex I 75 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
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        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
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        <property type="entry name" value="Mopterin_OxRdtase"/>
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        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
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    <dbReference type="InterPro" id="IPR000283">
        <property type="entry name" value="NADH_UbQ_OxRdtase_75kDa_su_CS"/>
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        <property type="entry name" value="NADH_UbQ_OxRdtase_ferredoxin"/>
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        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu"/>
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        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
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        <property type="entry name" value="NDUFS1-like_C"/>
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        <property type="entry name" value="NuoG"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN ADENYLYLTRANSFERASE SELO, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Fer2_4"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Fer4_NDSU1"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Molybdopterin"/>
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        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
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        <property type="entry name" value="NADH_dhqG_C"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SelO"/>
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        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
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        <property type="entry name" value="Formate dehydrogenase/DMSO reductase, domains 1-3"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="COMPLEX1_75K_1"/>
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        <property type="entry name" value="COMPLEX1_75K_2"/>
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    <dbReference type="PROSITE" id="PS00643">
        <property type="entry name" value="COMPLEX1_75K_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="21">
        <location>
            <begin position="647"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="23">
        <location>
            <begin position="725"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="22">
        <location>
            <begin position="864"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="37"/>
            <end position="58"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00005404"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00009747"/>
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    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022695"/>
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    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
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            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022840"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
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            <dbReference type="ARBA" id="ARBA00022967"/>
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            <dbReference type="ARBA" id="ARBA00031547"/>
        </source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00070722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU004523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="RCI17150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1358" mass="151125" checksum="2048C80AD7E33A66" modified="2018-11-07" version="1">MRLRAADLIRRTVVNMATGRSTGATLKDLPKTWRFTESLPPDRRFPSPATSHKTPRHEIRPRQVRDALFTWVRPDRQQDPELLAVSPAAMRDLGIRPDEAQTDDFVQFVAGNTLYGWDEDRLEGGYPWAQCYGGFQFGQWAGQLGDGRAISLFETTNEQSGTRYELQLKGAGLTPYSRFADGKAVLRSSIREFIVSEALHALGIPSTRALSLTLLPHSRVVRETIEPGAIVLRFAQSWLRLGNFDILRARGDRSLIRRLATYVAEEVLGGWQALPGRLDDPGRPADSPSPSRGVAADVLQGPDEVIENRFARLYREVVRKNATTVAAWQAYGFMNGVLNTDNTSIYGLSIDFGPFAFMDNFDPAYTPNHDDHMLRYSYRNQPTIIWWNLVRFGEALGELMGAGAYVDDPTFIAHGVLSRQEKGLVARAEKLITQAGDEYQAVFLAEFKRLMAARMGLRRCKESDFGELFGSALDTMEALELDYNHFFRRLSHIKLADIDSPQGKRQKASVFFHSEGPPKAVGDRDAREQLATWLEKWEIRVREDWGDPETNEEERMRAMQRVNPNFIPRGWILDEVIRRVDKERDRKVLDRVIHMALNPFQEEWGGDTDEEKRWVGDVPRPERAMQSWRTASTNHTRAFTTTPRQRAEVELTIDGKKVSIEAGSALIQACEKAGVTIPRFCYHEKLMIAGNCRMCLVEVERAPKPVASCAWPVQPGMVVKTNSPLTHKAREGVMEFLLANHPLDCPICDQGGECDLQDQSMRYGADRGRFHEMGGKRAVEDKNLGPLIKTSMNRCIHCTRCVRFANDVAGAPELGSTGRGNDLQIGTYLEQNLDSELSANVIDLCPVGALTSKPYAFRARPWELKHTESVDVLDGLGSNIRIDSRGLEVMRILPRLNDDVNEEWINDKTRFACDGLKTQRLTMPLIRRDGKFEAAEWGEALGEVTRAFCEEKKPQGNEFKIIAGALTDVESLVVAKELANNLGSDNLALDTPGGGRPLAHGVDVRSNYLFNSRIGGIEESDCILIVGCNPRLEAAVLNARIRKQWLRSDLEIGVVGQTWDSTFEFEHLGVDLTALKEALAGPFGKKLQDARRPMIIVGSGVTDHVDAKAMYETVGAFVSRNAAKFTTPEWNGYNVLQREASRVGAFEVGFVPPSSAVAETKPKFIWLLGADELKAADIPKDAFVVYQGHHGDRGAQLADIILPGAAYTEKASTYVNTEGRAQTTRAATSLPGAARTDWKILRAVSEFLGVPLPYDDVAAVRDRMADISPALLAYDVVEPVALQQLSKVQLVDQNRGVKAVGSPLGNAIENFYFTDVISRSSPTMARCSAAKAAKDPRTNFMAPGMEEDKPMGQVEYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LS59</accession>
    <name>A0A367LS59_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">leucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Leucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_2286</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Leu) + L-leucine + ATP = L-leucyl-tRNA(Leu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11688"/>
            <dbReference type="Rhea" id="RHEA-COMP:9613"/>
            <dbReference type="Rhea" id="RHEA-COMP:9622"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57427"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78494"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.4" evidence="2"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LS59"/>
    <dbReference type="STRING" id="1330021.A0A367LS59"/>
    <dbReference type="OrthoDB" id="10249672at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00812">
        <property type="entry name" value="LeuRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000001">
        <property type="entry name" value="Leucine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004493">
        <property type="entry name" value="Leu-tRNA-synth_Ia_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00395">
        <property type="entry name" value="leuS_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794:SF1">
        <property type="entry name" value="LEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794">
        <property type="entry name" value="LEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="69"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="230"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="12">
        <location>
            <begin position="846"/>
            <end position="966"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI17286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1133" mass="126708" checksum="820B0E0A52745BE3" modified="2018-11-07" version="1">MASTGAVPKAMETLTISQPKTKELKGTEKRDALIAIEKKYQQKWAEDGVFQQDAPSIQQVPLHSVSAAELREKEPKFFSCMAYPYMNGVLHAGHTFSASKVEFATGVARMQGKRALFPMGFHCTGMPIKACADKLVNEIRLFGRDFSAYNAEQEEEKEAAVPAAADDKAAKAKKEDVTKFSTNKSKANAKTVKMKYQFQIMKSIGIPQDEIHLFADPQYWLEFFPPLVIRDLSALGCRIDWRRSFVTTDANPYYDAFVRWQMNRLRELDKIKFGKRYTIYSIKDGQPCMDHDRAEGEAVNPQEYTALKLKVVEWAPKAAEAIKDKLPEGSDVFLVPATLRPETMYGQTCCFVGPKINYGVFKAGEKAYYLVTERAARNMAHQGILAQEGVVEKVCELTGADVVGTVVKAPLSRHKDGVRVLPMETVLPTKGTGVVTSVPSDSPDDYATITDLAKKADYYGIKREWAELEIFPIIETPSYGDLCAPFLVKKLKIASPKDTKQLEEAKELAYKEGYYQGVMKVGDFAGEKVESAKPKVRAQLLEAGDAFAYSEPERRVVSRSGDDCVVALMDQWYLDYGEASWKQTALGWVQKADGGKGLETWTSETRNAFEGVLNWLNQWACARTYGLGSRLPWDGQFLVESLSDSTIYMAYYTVCHYLHKDHFGRERGVGDVGPEQMVDGVWDYIFCRRELSEEVLKASGIPRSTLESMRREFEYFYPLDMRSSGKDLIPNHLTFFLYVHLALFPPEYWPRGVRANGHLMLNGEKMSKSTGNFMTLRDLVVKYGADAARIAMADAGDGVSDANLEEDVADNSILRLFTLREWCEEVVREQDGLRSGPPNSFQDAMLDNELNGLAREAIEQYGQTNYKLALKAALYELTGARDFYREGCSAAGIKMHRALVLRYVELQCLLLAVIAPHWSEHVWREVLKKETSIQEARFPEVAGVDAGLSAKRDYVRTTASSVHAVEAMQAKKKAKGKEVTLDPKRPKKLTIYTTDEFPGWQAKYVALLREVWRPGMEDKELSGRMAKMGEMKKAMPFVQGLKRRLQAGEAVETVLERRLAFDEKETLRQMRAGLCRTAGLVSCRVVAVEEGGKKGVGIDVEDGSEVTIEAGSAAAAAAEHAVPGVPTFLLENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LS96</accession>
    <name>A0A367LS96_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">General transcription and DNA repair factor IIH</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L249_2284</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the GTF2H2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LS96"/>
    <dbReference type="STRING" id="1330021.A0A367LS96"/>
    <dbReference type="OrthoDB" id="284275at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000015">
        <property type="entry name" value="General transcription factor IIH subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007198">
        <property type="entry name" value="Ssl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004595">
        <property type="entry name" value="TFIIH_C1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012170">
        <property type="entry name" value="TFIIH_SSL1/p44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00622">
        <property type="entry name" value="ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07975">
        <property type="entry name" value="C1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04056">
        <property type="entry name" value="Ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015919">
        <property type="entry name" value="TFIIH_SSL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01047">
        <property type="entry name" value="C1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="VWFA" evidence="14">
        <location>
            <begin position="132"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="12">
        <location>
            <begin position="355"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR015919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR015919-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCI17288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="489" mass="53369" checksum="EEA4A92B2DC1B3D2" modified="2018-11-07" version="1">MADSDGEYVVDGQSDDDLLDHTVSDDDYKEAGGGSRSKNGTTTTTTTTTTNKNQQQRRRRRKGDGGGGGGGGRKGGGSSAGQKAWEQSKRTWETNLPEEDADAILQLTAVEAEKRRRLLADTTPVQRGTIRNLVLVLDMSWAMAEKDMLPTRYQLMLSYASVFVRDLLEQNPMSQLAMVGMRDGIAIRISHLGGNPTEHLDKLASLEAQQPQGSPSLQNALEMCRGLLYHAPAHGTREVLVVFGALTSVDPGNIHDTIDRLVVDRIRVSVVGLAAQMYVCTELCSRTNGGDKSHYGVAIDDLHFRELVLEATKPPPTTEQDVPRLLHVGFPSAERHGKPVFCACHSRAVHETYACTRCCAHVCRLPADCPVCGLTLVLSMNLSRTHHHLFPLAHWREVSWDEAIAVTSSSSSSSSSSPYSSCCFACLHPFPLPPNPLPERREPIEGISESGRYACRECQLQFCMDCDVFAHTVLHDCPGCESGGAARKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LSB6</accession>
    <name>A0A367LSB6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2619</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LSB6"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI17308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="195" mass="21469" checksum="9D534FCE95AA3028" modified="2018-11-07" version="1">MICAIPPTIPDPRTVVPAVDQVPAYPTSTGSSSSSSSSSSSSSSSTSTTYYYRHLQTGIWALHPIPHHRSGQSSNFFLPPRPVYNEGPTYNAKPCAPCAVEWASSTCRHDWSALQRHVAVDEDDDAHQSFHLHTHASHATHYARTTHGCSLSRSTSNAARVPKPTTEQEFEQPKKKKEIVNKPDDHSWEGLHVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LSH2</accession>
    <name>A0A367LSH2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_2893</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LSH2"/>
    <dbReference type="OrthoDB" id="2504919at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.20:FF:000012">
        <property type="entry name" value="DUF803 domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF86">
        <property type="entry name" value="ADR321CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="352"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="396"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="485"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="503"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI17405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="517" mass="56225" checksum="4A0B07EDC3DB7D18" modified="2018-11-07" version="1">MAPLGGISPGGSIALGIVVGLMSTSVQSLGLTLQRKSHILEDDKYPHDVRRPPYRRRRWQLGMAMFIMANLLGSTVQISTLPLPVLSTLQAAGLVFNSICATLILSEPFTRWSLCGTVLVTTGAILIAVFGAIPSPAHDLDELMELMGRKPFVAWMILQALFVVGIAVFIEVVNKSSNLSLNSRFRLVRGILYGVISGDLSAHALLFAKSSVELIIKTIGGSNQFAHWQSWMMVLALVVLALCQLYYLHRGLKLVSTSVLYPLVFCVYNIIAILDGLIYFNQTSFISPLRACLITLGTVILLSGVLALSWRLSDEQHPPGVGQSTLAPGLGLVEDTEGEEESLLGTESVVGEDDATPTYETFPPTVNGDTTAMTPAPRNKSFRWAERAEIWGELHDRQEAGLPSGRHRSSTMPGRSESTPLVPRSGSRRIEAEAAAEAGASSDSTPRRLGRRRRRSTGFPGLVARRNVRKRSESTSGSLRNMLTLGWWTGRGSRSSLGSWSRPTTTRDNSNQAEGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LSJ2</accession>
    <name>A0A367LSJ2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BRO1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_3119</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the palA/RIM20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LSJ2"/>
    <dbReference type="STRING" id="1330021.A0A367LSJ2"/>
    <dbReference type="OrthoDB" id="64867at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09241">
        <property type="entry name" value="BRO1_ScRim20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.560">
        <property type="entry name" value="alix/aip1 in complex with the ypdl late domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.50">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025304">
        <property type="entry name" value="ALIX_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030">
        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030:SF39">
        <property type="entry name" value="PROGRAMMED CELL DEATH 6-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13949">
        <property type="entry name" value="ALIX_LYPXL_bnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="3">
        <location>
            <begin position="9"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="835"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="835"/>
            <end position="853"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI17424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="866" mass="96589" checksum="211BE64284BA7BEE" modified="2018-11-07" version="1">MSTMTTTSSILSVPFRKSTNLALSSTIQQYISTKYDQHPDMFRQDLEVVDALRRDAVNVREPHPSGIKKLQAYAGQLAWISGKFPIDIGADFTWYPALGYNTERPMVRNNLKYEYMNVLYNLCALYSQLAANSPRASSEGLKVAAHNFNLAAGVLSHIQTAVLPELRMSDPPDDMDQHTLEALKQLLLAQSQECSWQSGIMNELKDLSIAKLAARVSDLYNLAAEAAVRSEAICSAWIHHMTAKHHHFAAAAQFRASRDCLEKRKYGEEVARLRDAVACVSEGLKETKGGYLSKNIVDDLNGLKRKADDDLKRAEKDNDMIFLNPVPPKCDLKILDRFNMAEAKVPPQVAKPFDYLGDKAEFGPALFSRLVPFSVHMAVSIYEERRDRMVNQNIIQELETLTAKMHSHVSAVGLPGSLQALEKPLGLPPSLKQHAEELRQGDAIGRVHKCFEDIDKLRSTDLAMFEAGKSALAAERDEDERLRRKYGTERWTRPDSLSDPQGAKLWSHASEIDGYFQSSVSSDSIVREKFAANEDLLRLLCGPDRELMQSVPSGAQRETSSELKSAVGKLRSVYNDVLRLESRRRKKMERLRESARGDDIKPDMLKEAARLERTYPTTAIVPAHFEDFFEQRLDRLYEPELEVIDREAEEQEKLLTLVDRANSEFEAQKRKAGDRGLREREEVLQKLDSAYFKYKEIVNNLEVGRKFYNDLSKIVGQGFRDVAKGWAAERRMDARGLEGELSMPPLSNLGISRDVTTPLHSPQPVLPMAYETGQQQAYYAAPEAQHAPLPQRPSQSAAEATIQSWAAQSMPMPQPNAGARGGIWNPGMGIKFGGGGGGGGGVDGQGQGQGQERGGTWDPNAGIRFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LSM1</accession>
    <name>A0A367LSM1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_2674</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LSM1"/>
    <dbReference type="STRING" id="1330021.A0A367LSM1"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051698">
        <property type="term" value="F:saccharopine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF37">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="4"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI17387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="426" mass="47011" checksum="DF01DFB4D75FD422" modified="2018-11-07" version="1">MTSYLIIGAGNFGAATALTLAKRGGARVTLVDSAAYPNPRAASYDVNKIVRDDYPDKLYMRMLIKAMPKWRQDKLYNAYYHEVGMLRADESNFGVESIAAYKDMGVANESEFLPVDEVRRRWNGAFATSNFGGLPTILYNPTVGFAEADKALEAVVQAAVDHGVEFVEASVERLDFDASGQCVGVSLKDGRGTLRADKVLLAAGARTPALLAQSAPDNKDLHVGPRVVATGAISFHAQLTGEQKDKFAPIPVLKNCLPDVKGEGMSMLKDGTIKFNCDMCFTNYVTFPPTGQRMSVAPEEDMYNKWTGPRFVKFFQDRARKTMNGLYGKEVEDIFIQQYRMCWDASTPTHDFLITPHPHCQGLYLATGGSFHGWKFLPVIGDYVADMMQGCLDEDYAARWAWDKKGGDGHSANPTYAVVGDLQDWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LSM4</accession>
    <name>A0A367LSM4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L249_2897</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LSM4"/>
    <dbReference type="STRING" id="1330021.A0A367LSM4"/>
    <dbReference type="OrthoDB" id="5357315at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04813">
        <property type="entry name" value="PA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000364">
        <property type="entry name" value="Protease-associated PA domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051653">
        <property type="entry name" value="E3_ligase_sorting_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47168:SF1">
        <property type="entry name" value="OS02G0798600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47168">
        <property type="entry name" value="RING ZINC FINGER DOMAIN SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016786525" description="RING-type E3 ubiquitin transferase" evidence="13">
        <location>
            <begin position="24"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="541"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="677"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="128"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="287"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="398"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="586"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="730"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="154"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="398"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="603"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="773"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCI17409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="812" mass="87489" checksum="DAB016B4096B412A" modified="2018-11-07" version="1">MRPPRIAVLALFLAASIFILGRAFTPTSRPHASSSYPREARSSRSVFGFMYYNTPFSLFPPNAAISLTDDNSTSFAARPAAFGPKLAATGLSGQLWVGSGFAEDSQDGDGELGCSDLPGWGSGNSLRNSFRAHLPKSPNSSPRLLDSDHRESGADASDASTITTTTTITHAKTHPGRGVASVGSLSRRDASSSPVHADIQSIQEAAEIQGKVVLLMRGGCGFLEKVMWAQRRGAIAVIVGDNQKGGPLIQMFAHGDDVENVTVPSVFTALTTAHLLSSLTQPGSFIEDTLDDNGNPVRKVQQGPKTPDGKTRIVSPGKATEPSAGSPKTKDKRAIEPSSRAPAASRSWLSRLLGWGQAPLIVHEKSRPPSSGRLGWEVIDNWSDESDKVIREGLRRSTKHKLADDHSVMSDHRDSVMSDHRDTAKDVDSFSQEKVFGKTSRKTSSKTSGGKEANGPQGGSITPGSGDYTSARLALRDGKKAADGSHSLISRLFGDDKGIAGKATKHNTGSKPARNRDFPPHEGLWVTITPTSSASPFFDTLLVLVISPLVTLTVVYALLVVRARIRRRRWRAPKSVVDRLPVRTYHTAVSSPSPSPRLPSPSGATPTTPLLQHSPTRSRPRSRTTTGVVQSESLLVPSAAVPTPAGSARSGTRSEHEKGAGGFSAEWRKYMGRQVECVVCLEEYVDGVSRVMSLPCGHEFHADCITPWLTTRRRTCPICKGDVVRSLARGARDGPRYEPYNDGSDEDMDVEAPGSRPTDGTSDLERGILSPRPGRDASRQDRRDGWLAMLSSSFNPRMRHRSQSPQRGDRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LTH0</accession>
    <name>A0A367LTH0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Peroxisomal membrane protein PMP47B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_2421</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LTH0"/>
    <dbReference type="STRING" id="1330021.A0A367LTH0"/>
    <dbReference type="OrthoDB" id="2019556at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080122">
        <property type="term" value="F:AMP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005347">
        <property type="term" value="F:ATP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015228">
        <property type="term" value="F:coenzyme A transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015230">
        <property type="term" value="F:FAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044610">
        <property type="term" value="F:FMN transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051724">
        <property type="term" value="F:NAD transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000119">
        <property type="entry name" value="Mitochondrial carrier domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000152">
        <property type="entry name" value="Mitochondrial carrier domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF5">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="8"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="108"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="216"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI17442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="33684" checksum="56F8C6D99AA86193" modified="2018-11-07" version="1">MTSSLPQNDNVAHALAGAGGGILSMILTYPLITLSTRAQVESTKAETGFAAAVRRIVAREGVAGLYAGVNSALFGISVTNFVYYYWYEWTRGFFERAARSAGRASKKLTTVESMIAGAIAGSATVVITNPIWVVNTRVTTRRQSTADADPEAAGGSSRVAATPSTLGTLMSLLRNEGPQALFAGVIPALVLVINPILQYTFFEQMKNAVEKRQRAVTPTIAFLLGALGKLLATSVTYPYITVKSQMHVAGHNKAKKEGMSQTLRRVIKDEGYAGIGPKVTQSVLTAAFLFAFKDVLYEQTIRLRTAAARKRLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZ63</accession>
    <name>A0A367KZ63_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">N6-L-threonylcarbamoyladenine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_4513</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="9">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="LKCN02000028">
        <property type="protein sequence ID" value="RCI07469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZ63"/>
    <dbReference type="STRING" id="1330021.A0A367KZ63"/>
    <dbReference type="OrthoDB" id="10254073at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd24132">
        <property type="entry name" value="ASKHA_NBD_OSGEP_like_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000038">
        <property type="entry name" value="Probable tRNA N6-adenosine threonylcarbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01446">
        <property type="entry name" value="Kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034680">
        <property type="entry name" value="Kae1_archaea_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03722">
        <property type="entry name" value="arch_KAE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF14">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="10">
        <location>
            <begin position="48"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="149"/>
            <end position="153"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI07469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="358" mass="38366" checksum="555806C243834BB4" modified="2018-11-07" version="1">MESSPSPPPPIKGAYIAIGLEGSANKLGIGLVRHAPPSRPTILSNLRRTFIPPPGAGFLPKDTAAHHRKNVASLAVEALSVAGVHPSEVSCICFTRGPGMGAPLASVAVAARTLSLLWGGVPLVGVNHCIGHIEMGRLVAEASNPVVLYVSGGNSQVIAYADHRYRIFGETLDIAVGNCLDRFARCLELSNDPAPGYNIEQLAKRGTKLLDIPYAVKGMDCSFSGVLAAADALAKVLRRRDPPPDFTPEDLCFSLQETVFAMLVEITERAMAHVGSNQVLVVGGVACNERLQNMLGRMASDRGGTLHATDERFCIDNGIMIAHAGLLAYRTGFRTPLDQSQCTQRFRTDDVYVNWRDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZV2</accession>
    <name>A0A367KZV2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_5676</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000024">
        <property type="protein sequence ID" value="RCI07694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367KZV2"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd19542">
        <property type="entry name" value="CT_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19534">
        <property type="entry name" value="E_NRPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19545">
        <property type="entry name" value="FUM14_C_NRPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.30:FF:000002">
        <property type="entry name" value="Nonribosomal peptide synthase Pes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000005">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF12">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE IVOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="428"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1512"/>
            <end position="1588"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="3323"/>
            <end position="3397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="386"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="868"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="386"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="415"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI07694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="3397" mass="368401" checksum="B30191B23A17BC4E" modified="2018-11-07" version="1">MGSSPAQLTKGLPALSQQDPDGVLAEPIEACVHSLIKRHVVERPSAPALCSRDGELGYGQIDVLSSRLARQLALVPASTVVLCFEKSLIAPVVALAVFKAGAVAVALDLDQPLDRLRAIVGRLSDPVFLSSSANASLARQLAPGPVVVLDPDTLSAPVSEANAGLPPVSPSDTLCLVFLSDDLHGLTGATVSHRDMSSAIVYQQRKLGYAADCRTLDAAPPGSYTAWCNMLHTLASGGCLCIPSAADDVWSSAAALRANTAHVTPDLARGLLHKSGPAGRLHLTLVGEPLATPESDPDSSTAQTLCSLSDGVRALLDDPPLSHSLGRSVGRLRPEGPLFRPAPDSAEILNSATSLASTWSGCCGWTCSAGDVVTCADGGVVVVRVRPVDGEPKSQARGDSEPSEDSIENMQFTSESEETLDTPEAEQVDSSDMEQLLLPLWAQVLQINPDKISSDDDFFELGGDVAKSMRLHALARQHGFYFSVRDFFRGPSIRQLSARTSQTSAAPAVSPFSLLDKTSLNLDETRAHVAQLCGAQTSQVVDLLPCSPLQEGLLALTQRLPGSYVAQHVYEVDEGVSASRLRRAWDQVVAMNPILRTRVVSLPSQGLVQVVLDQGAPWLSATDLDDYQRRRSGTEQQIGLGTPLSRFAMLDNGAGGARPCFVWEIHHALYDGWSLPLLMAEAEKAYYGEMGQDLQPMTGFIKYIQDGDEMAAKAFWRAQFTGIQEVHFPRPRPAAAGSRSAALLSLTVPNLGWGRSDFTPATMARAAWAVVMARGAGSDEALYGVTVTGRQAPVDGIEHMAGPAIATVPMRVRLDWGDSVYKLLDAVQRQSTDMIPFEQTGLQRIRRMSDEAALACSFGSLMVVQPAAAGGDGEGGDSPTRPFLSKPGGDDDDDDDDQAAREAAPVTYPIEVECHLGTDEARLRVEFNPDAISRREMEAITESFEQVLRKLADRSLAQEKLASLVASHSDRRVQDALGWNATVPEPVEQCVHHIFSSRVHDRPLAPALDAWDGKLTYRELDSRSTTLALRLVARGVSPGMLVPVLFEKSAWMPVAVLAVMKAGGALVAMEVKEPEDRLRTIASQVTSPVLLSSVRNAALARRLTADDMAVEVIGDDARSESADAEPQHALDVLPVVSPSSLLYVVFTSGSTGTPKGVMISHSNFCSAIAYQQQFLDYNQNARVLDFASCAFDVAWSNLFNTLTSGACLCIPSPEERENDLAGCLSKYDISFADLTPSVARALGPDVLSRLTTMILGGEAPLPSDALLSSGKTHIINAYGPAECTPTATLSTLDATDVSIGRGLGVCTWIVDEAESLTPVGDVGELWIEGPLVGQGYLNDPERTAAAFVRDPSWLQRAVGRRGLVYRTGDLVRYREDGALVFIGRKDTQVKIRGQRVELSEVESCVRQLMDATDAQVVAEAIQPAGSGNPILVAFVALPVDDHDEAVRKATEGLSDRLRQVVPSYMVPAAYIPVPEMPVTTAGKTDRRRLRAIGASMWAQYRIATEKKGPSTQPANEIESILQKVWMSVLNLSAEEASVEASFASLGGDSISAMQLVSRCRLHNVMFTVSDILQSNTIRRLASLYKPVASVTGSELLTELEREEEEDPAAEFDLSPMQQSFFRDYPDGLNHFNQSFLLDLGQDVTTQQLMNAMKALVSRHAMLRARFLRDPGSGVWRQRIEDEGPDSFAFAEHTVENRDEVGRIGQKRQGDLDICDGPVFACDLFHVPDGGGGGEGGGQVVLLSAHHLVIDLVSWRILWNDVEEYVKLGELQLQKTLSFRSWCAAQAKVGSSLSPLSVLPYPIPEPELDFWDLPLEENTFGDCDTLDVGLDPDVSKLLFGKSNESLRTEALDLILGALSYSFHQTFPERSVPAIWIEGHGREQLEDNLPTDVSGTIGWFTTMYPLAVPIGADQTVTHAVRLVKDTRRKVPRMGLPFYACQHYSESGRQAFRGHDVYEVVFNFTGRFQQLEREEGLFKSSQTTDESDVKITEISKSARRFLMLEIGAVVADNALAVSFNYHKGMKHQDRLREWSQTFVRVLESAVHLLARAPVGFTLSDLPLLQLSYRGLDSLVMEQLPRMGVKPQSILDIYPCSPLQEGMLLSSVKGAASYITYTIWRCLSTDGAVSAVKLEEAWRKVAGRHTILSTIFALHPEGNGFLQLVLDKPPVRVTHLRCGSGSPAETLSRLPESTFADDEPEHALVICQSDTGEVACRLDMSHALTDAHSSSLLLTELATAYLGNGELTVAPAFADIVRYINSTSRSQIVSTWTSLLDNVKPCEFPLSPVVPDDSIQETFTELSCNASLHISINEFCKKTEVMPSALIQVAWAMVLSHMTGMRDVCFGYLVSGRDAPVDGVENLVGPLANLLISRVNLGASARQVLETTSEGLKQHLSIQHVSLAEIQHHLGLSGRRMFNTSLSIRANDKEKSDTAATGLSFDIQAGGDAHEFDVKCNASIGGADIDLSVEFREPYVSRRVALEARSTLESAIGYLLANTYPDLDIEGLAEAKGETDIDLDAMTLHGGFFKHTTGVHDSDATSFWEAQFAHTQGTHFPQPKPSIQHSVLDDSMDLDIGTLDWQTDEFAVETMVRSAWSVLTARVMCSDESIFGTRVSGNDVMPIRVVVDWDRSVDSLLNQVQGQSTAMKPYGRMGMERVRRVNGDAALASGFQTLLTVLDDDDDDDDEAQGVERRGDDADHVTHSLEMTIRRGKTMMTRVSARFDSRIINQVRVSRIVHQFAHVLQQMLDTNMRQGKLREVTVASKRDLQDVWTWNADVPSPVTGCIHDDIVRNAETHPHAQAVHGWDGSLTYKELEEVSRNLAVRLMKRGVGRGSIVPLCFEKSMWMPVAALAVMRAGGASVAVDTTQPQERIRTMTSTVFAALEGPKVILSSVANEAMVSQLGADEVIVVCRHGLDEVEEAESEAPELPVVSPSDVLYVVFTSGSTGKPKGVVINHQNFYTATHYQRTLLGVKRESRVLDFSSYAFDVAWLSMLKALTAGACLCIASAAERQDDLGGCLIKYGITVVDLTPAVARVIEPREALSSLDTLILGGEAVSAADADLVGDKTQVMVAYGPAECTPTCSIMNLSKTRSHGIGHGVGMCLWVVDLENADGLAPVGVTGELWLEGPLVGMGYLNEPQKTAASFVRDPAWLSRGSPDGKRPGRRGCVYRTGDLVQQLEDGSFLFIGRKDTQVKIRGQRVELGEIEHHVQQTLEESGRVGKVHVAAETIQPRGVAGKMLVAYVAAEGTTKAGADDDEVRQAAAAATDKLAKTLPVYMVPTLYIPIKALPMSATGKIDRRRLQEMGSSLTAKDVAAMSRAGEQRRTPQTEAERTMQSLWAEVLHVEAESIGADDSFFRIGGDSIGAMRLVGLARFRGFEFSVRDVFQSPVLSDLAALEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0E5</accession>
    <name>A0A367L0E5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Matrin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_5789</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3A2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000023">
        <property type="protein sequence ID" value="RCI07898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0E5"/>
    <dbReference type="STRING" id="1330021.A0A367L0E5"/>
    <dbReference type="OrthoDB" id="10250970at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052092">
        <property type="entry name" value="SF3A2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031781">
        <property type="entry name" value="SF3A2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205:SF0">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16835">
        <property type="entry name" value="SF3A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01050">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="11">
        <location>
            <begin position="54"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="86"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI07898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="242" mass="27737" checksum="B39CD1A54FBE18D9" modified="2018-11-07" version="1">MDYQNRAGSKFGGGGVASHSATNADRRERLRKLALETIDLDKDPYFFKNHVGSFECRLCLTVHQNDGSYLAHTQGKKHQTNLARRAAREQKEGRHQDRHTAIDPATGLPYSALVPGPRRNVVKIGRPGYKITKIRHPVSRQQGLLFQLQYPDAAPEVAPNWQVMNAFSQHIEEPDKNFQYLLVAAEPYETVGFKIPARELDKREDRQFCFWDPDGKEFWIQVMFMTEREERFNAAPGLTGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0S6</accession>
    <name>A0A367L0S6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7888</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000022">
        <property type="protein sequence ID" value="RCI08039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0S6"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI08039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="70" mass="8079" checksum="37756DA1C97205A3" modified="2018-11-07" version="1" fragment="single">HFLKSYNLYLARYLFILRFLATSLREILLALYITPTPKAPLIISLLSKVSNFANFFSKEKASALLLYYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0X8</accession>
    <name>A0A367L0X8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_6273</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat ELP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0X8"/>
    <dbReference type="STRING" id="1330021.A0A367L0X8"/>
    <dbReference type="OrthoDB" id="27911at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000400">
        <property type="entry name" value="Elongator acetyltransferase complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037289">
        <property type="entry name" value="Elp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44111:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50993">
        <property type="entry name" value="Peptidase/esterase 'gauge' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="7 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="51"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="205"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="295"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="403"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="521"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="522"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI08090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="830" mass="90321" checksum="2B8B4636042AD897" modified="2018-11-07" version="1">MVSVDYLAIGANRHAAVADWDRNGLLAFGADVNVALWRPNLVPPRGIEQLLSGHTGTVKSLRFLPEPEDDSCYLVTGSDDRTLIVWASTGQDQPFKALQTCSDHTGAIDCIAAVRLAGDDARWIVATGAADATIRLWLFANRRLLLRQTIQPTPKFFPLALAMTALADNGHPLVLAAAGTRDVVQILTADDTNVETFEFRLQATLSGHEGWIRSLSFAKENNSPGSDLLLASASQDKYVRIWRFHEGRHLPAPSTSAAGPWDSSTFVEEGKLPSNKAHRLTSAGRDFSVTLEALLLGHEDWIYSAAWSSSHDGGKLRLLSASADNSLAIWEADKSSGIWVSQARLGEISIEKGSTTATGSTGGFWTGLWSPDGLSVACMGRAGSWRRWRYEPADDAWRPCIAVSGHTRAVRGISWSGDGGYLLSTSADQTTRLHARWKATGSWHEMSRPQIHGYDLNCIGSLGRSRFVSGADEKLMRVLGMPKTVAALLEKVAGVYETDADHMPDAANMPVLGLSNKAIEATTDDDDDDDDDDDDDDDDDDHHHPDGGETTDGSGSSPPLEETLSRHTLWPELEKLYGHGYEISCLAASHDGRLVASACKASSANHAVIRLFETQHWTEVKPPLTAHSLTTTRLRFSADDDYLLSVGRDRQWAVFERDQGTYRALQSNSRGHSRMILDAAWAPPPPPPSCGASRIMFATAGRDKQVRLWAAGPQAEEQEEGQKQFAQTASLTTESPVTAIDFLPQRVDGRAVLAMGTEAGRLSLCLVSGDGSEISQLPPQSELAFPRAVLQLAWRPPDSDDTRRLHHILAAAGEDSSLRLFSWDGKSWLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L114</accession>
    <name>A0A367L114_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminodeoxychorismate lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_6317</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L114"/>
    <dbReference type="STRING" id="1330021.A0A367L114"/>
    <dbReference type="OrthoDB" id="5288718at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI08129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="30836" checksum="44554CC4FB4CBA93" modified="2018-11-07" version="1">MSEAPFYLLTSLRHDVELESLFTGDSRHIGWNYNHKSPLYMLDFHRDRLLRAAEHWGWNEAVEKLSGDEALHELARMAQDAAVDTTTKPQRLRILVNSQGTLTFQKFDTPSQPLENLYPRLLTPPSLTAGPDEHPPPPCFDLVVDDSATPRSEFTHFKTTWRAVYDAARRRAGIRPGDLKEVLILNADERSVMEGSITTPYFWRRDRWVTPPVSPRFSLDKGSGGHDGTSRRWALDRGLAVEEAVLVDSLSDGEECWISNGVSGFQRAVLHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L180</accession>
    <name>A0A367L180_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">6-phosphofructo-2-kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_6282</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L180"/>
    <dbReference type="STRING" id="1330021.A0A367L180"/>
    <dbReference type="OrthoDB" id="267323at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000031">
        <property type="entry name" value="6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001280">
        <property type="entry name" value="Related to 6-phosphofructo-2-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF39">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE_FRUCTOSE-2,6-BISPHOSPHATASE YLR345W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="4">
        <location>
            <begin position="64"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="514"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="514"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="561"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI08193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="570" mass="64689" checksum="F7FD31AF62C90E2A" modified="2018-11-07" version="1">MDTLLWVDRLFHLTLVKEADADVYRTAKIAANAPRYRRRSSTFLDGIHDVIEDQDMAPAQLYSTMSGRLFHSGRIAIVMVGPPARGKTHICVSLARYLQWLGVKTRIFHLGDYRRATVGPEGSVPEDYFFPNASPSSAMLRQKILKKCREDIYAWLNHENGQVAIYDAVNPTASGRRSLAKELGKHDVQTLFIESYVDDERILRENARNVKISSPDFAGMDPDEAAKLYLKRIEMRIPMFETMNEAELNYIKMINAGAKFFYNNVSFNYLSHRIVFYLTNLHIKSRKTFFVRAGTTEMEDSYKADAPLSEQGKVYAEKMSKTLLKHREQEQAEQAEKGGAQTSLRPLTVWTSTRRRTVQTADYLREQGYKVRQRSQMSQINPGVCEKMTERIIRQIYPEEVEKHGLDPYHHRYPRAESYHDLAVRLEPIILELEREQNDLLIIAHESVLRVLYAYLMHCSTMQIPCLKFPRDEIIEIIPAAYQNEAKRIHIPGLDPRLLPGSPDDITVPLRMAGASASGKESSGGSAPSSGQMSPIAGGIGSPALPVERPPEKVINTAKDMVADKVDDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1V5</accession>
    <name>A0A367L1V5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1V5"/>
    <dbReference type="OrthoDB" id="10676300at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016875405" evidence="1">
        <location>
            <begin position="24"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="263" mass="29074" checksum="13F936B16E3FD0D8" modified="2018-11-07" version="1">MPAFSQQALNINIVLLFLAVADETTNHSMRRGIANWAEPSVPSSASEHSACLDAPLPAKPGIYRLASPQTSIQTQRLTRELKVPFLRTSHVQLERLLQVVPQASHVAVSRRPSAAHFPKSLTRFPRPLFVDDLFWPRAVASASTSFRFFFFSPTFVTWSRSSQVQVFQQLGILKFGAKNGLDRPALTEPVEHSPVVRQYSPRGKFDSYPRTLIPRSSQGNQRSLALHAYTVSATAASRDATAQRSLLLAQAQESCVQGHAVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2I5</accession>
    <name>A0A367L2I5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">hydroxyacylglutathione hydrolase</fullName>
            <ecNumber evidence="5">3.1.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glyoxalase II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_4878</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an S-(2-hydroxyacyl)glutathione + H2O = a 2-hydroxy carboxylate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21864"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58896"/>
            <dbReference type="ChEBI" id="CHEBI:71261"/>
            <dbReference type="EC" id="3.1.2.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.6" evidence="5"/>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2I5"/>
    <dbReference type="STRING" id="1330021.A0A367L2I5"/>
    <dbReference type="OrthoDB" id="515692at2759"/>
    <dbReference type="UniPathway" id="UPA00619">
        <property type="reaction ID" value="UER00676"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090730">
        <property type="term" value="C:Las1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004416">
        <property type="term" value="F:hydroxyacylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07723">
        <property type="entry name" value="hydroxyacylglutathione_hydrolase_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035680">
        <property type="entry name" value="Clx_II_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032282">
        <property type="entry name" value="HAGH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007174">
        <property type="entry name" value="Las1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935">
        <property type="entry name" value="BETA LACTAMASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935:SF94">
        <property type="entry name" value="TENZING NORGAY, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16123">
        <property type="entry name" value="HAGH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04031">
        <property type="entry name" value="Las1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="11">
        <location>
            <begin position="370"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI08634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="641" mass="71191" checksum="7AF7F50D30770FEC" modified="2018-11-07" version="1">MVRYVFNSWRRRHDLLLVRRQFYPGDHRDDSRDDDGDAAAADDDDDDDDDVEDARQLAVGRVSMWMTRQHCPHLVESTALLTAALLTDEADDSRRLSSSCPPSVAYAVRAAYAAAFSRFVTGLLDGHQDKLRKQSMYTIAASIGLPSAFVELRHQSTHEQLPSRARLRAMAERALVWIWDYYWKHLDAAPADQQHHPDDDCRAAVLAFLRAADDVEREASQRAAILCRWDRDRVLATISRLQNTLPGNQAFLKCLSLSRHVMEQPRQEVEPPPLETDQGGVVVEADANTVYVGDDVDDDDDDDDDDDAPVAWSLLDGHWKPIPIGVRLPLILMVLSLLSRRQLLVQIIPKLAARRAMHIQSIPMWVGSSNNYAYLVVDDKSKDAVIIDPANPPEVTPVLKKALEDGSIKLKAIVNTHHHWDHAGGNKKLLAELDAVPNLDVVGGKDCEAVTKTPAHGETWKLGDISVKSVHTPCHTQDSICYLMEDQTGRAVFTGDTLFVGGNNPAPYLPINITMSDTIGTYIHSTGSGCGKFFEGSAAEMHEALNKRLASLPDDTVVYPGHEYTASNAKFAMSVQPSEAVEKLQRFAADGTVTTGKFTIGDEKKHNVFMRVEDPEIQKVTGTTEPIAVLEKLRDMKNNFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2Z7</accession>
    <name>A0A367L2Z7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2Z7"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="101" mass="10967" checksum="BA3452D3490FA286" modified="2018-11-07" version="1">MVRKHDRPQRFPACRDSTQDETANTTTTTTTTTTTMKNQARTVRSGDCRTGPGTHRLPGPASTVPGGTIQYNRTTLAFSLFVSAQLRSALCKHMPSPNTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3D9</accession>
    <name>A0A367L3D9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ribose-phosphate pyrophosphokinase 1</fullName>
            <ecNumber evidence="4">2.7.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Phosphoribosyl pyrophosphate synthase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">L249_4930</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15609"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.6.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.6.1" evidence="4"/>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI08918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3D9"/>
    <dbReference type="STRING" id="1330021.A0A367L3D9"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009156">
        <property type="term" value="P:ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000017">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000043">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000842">
        <property type="entry name" value="PRib_PP_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF57">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00114">
        <property type="entry name" value="PRPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="18">
        <location>
            <begin position="5"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="212"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="213"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="259"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00077829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RCI08918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="488" mass="53123" checksum="8466886359C449BC" modified="2018-11-07" version="1">MRNTLIFAGNSCPALTGQICEHLGMYAADAELTQFSNGETSVRILTSVREKDVFVVQSGSTRVNDSIMELLIMISACKGGSANKITAVLPYFPYSRQSKKKSHRGAITARMLANLLGVAGVKHVITVDLHASQMQGFFKCPVDNLHAEPIIAKWIRANVPDWREAVVVSKNAGGTKRATSLADALKLNFGMVTTDRKRGTSMTTSIVLNPADRCVEAPHTPKSENGRGVVRETIPVRSSRTITDARGSPIRQVEVPLKVSGSSPQSVVVSTKTPPPPRSSRRPSTNGDQDYHDERVREVIHGRLVQGHLVEDNFPSVERSAEHGILDDDSMTTSHASSFFTHDRQSHGGGDPAVSSDEEDDAFQNTKDEHMITLVGNVKDRAVFIVDDMIDKPGSWIAAAETVVKKGRAKKVFCIATHGVFGGDCLQQLQACECIDSIVVTNSFPISQETAMRTGKLIILDLSSLLAEAIRRNHYGESISPLFLHTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3K4</accession>
    <name>A0A367L3K4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LPXTG-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_4789</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3K4"/>
    <dbReference type="OrthoDB" id="5239590at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017058682" description="LPXTG-domain-containing protein" evidence="3">
        <location>
            <begin position="34"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="367"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI08792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="45329" checksum="35A1F0A955C5DFBF" modified="2018-11-07" version="1">MKPRRLSISRGGTTPTTQQLLLLLLLATTASRAVLVAPGSPCSTGCGNVLASTSADDVVCDTGAYNSSAVGQLFQGCVECEMRSGFGRGDETDVKSMLYNLRYALSYCLFGYPGNSQLGSTPCITSKACGPFRDATLYGNLSSRYKGYEYCESWPLSRGGDVDYRACAECLQAAENPYLANFVVVLEAGCEQKPVPGVDLGMTGQVFSHDYVNVTAPSPTATVNPAWFDQGRLGLGGKVGIAVGSLVLVLIIAGCAVVVNGRRRKRAYLCRLEARYGPSSSKTGEKEPASAGGRAWDDTPSSQQPLRPWDDRHMSPCSSHYNSPVSPSNTHLSLSALGIIHQPEGKGKEKEEVIEMQQQEQEHQHQHQQQQQHQQQYQQHVDHRIVPPPAEAPVLGHPGFGRSLDEPPRQYEADAKRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3L1</accession>
    <name>A0A367L3L1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_4973</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI09021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3L1"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI09021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="83" mass="8966" checksum="F01885B3C2D2D6AE" modified="2018-11-07" version="1">MVFVLDISVEERSGLGFWIYVGKRFERSGSLLGSRLPVLATEGRGLSLGSVCQGYDQMVGALVTVATWPEGSVFVRRVTARSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3S7</accession>
    <name>A0A367L3S7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase M48 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_5121</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI09079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3S7"/>
    <dbReference type="STRING" id="1330021.A0A367L3S7"/>
    <dbReference type="OrthoDB" id="7464992at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07331">
        <property type="entry name" value="M48C_Oma1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051156">
        <property type="entry name" value="Mito/Outer_Membr_Metalloprot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726:SF1">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="8">
        <location>
            <begin position="118"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI09079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="342" mass="38885" checksum="EAEC58140C2F5476" modified="2018-11-07" version="1">MLRRSVHIRQLSQLTRRQREEALRNARPLVPTALADRFARPLPGRKRIMLASAFAVSALTFYLLNSETVAQTGRRRFKFLSSRFLAYVYADEYDKVVRLMQDRGQWFLPDHDARVVIVRRVMERLLPFSGTDEELRWRIHVIEGPESIANAFILPGGNVFVHSFLINACYSEDALAAVLGHELAHAAVEHQAEDASAIWAGTLTAGFLFFAAGAIPGLALFLLWGAGGGYYLGDFLLRLPRSRKHEAEADYVGLMMMAEACYDPRAAIGFWELMETLRSYTKVDAVPELLSTHPTHENRLKNIKEWLPEAMQRRHQNGCDNLSVFHRVVESMTSSSKRRRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3T8</accession>
    <name>A0A367L3T8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI08872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3T8"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="188" mass="21068" checksum="A75DE8471792106F" modified="2018-11-07" version="1" fragment="single">MHHTLSLPLFLPPPPPPPPPPPPLRLRRSERRSPPTIPLPPIPSHSRPAQRSIFSPPFPPPYPCPLDLPGSLPPGPIMNRDILFPSLSFSRRDTLRRFPSPLPTAQWGPRRPALCDQLKGRKSNGPPPTTWLSAHTHTPLSPTLLFLSPFFCFFISRPHIFSPPPSMTHHHPDVRGLEAARDSTPQEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4M5</accession>
    <name>A0A367L4M5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_3767</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000015">
        <property type="protein sequence ID" value="RCI09358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4M5"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI09358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="113" mass="12597" checksum="724C1E3D157649B3" modified="2018-11-07" version="1">MAPLASAWEALLSGWPGKLWRWGSCSPPRHAIHGSAIQQRSSPVAIGHRIQLFICISFDGRHNSKLSFTKRFFGHGENQLRARWVGYGPPHELLSATDPQLRKGWGNLSLSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4Q3</accession>
    <name>A0A367L4Q3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3664</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000015">
        <property type="protein sequence ID" value="RCI09397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4Q3"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052635">
        <property type="entry name" value="Sec_Metab_Biosynth_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39607:SF1">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39607">
        <property type="entry name" value="XANTHOCILLIN BIOSYNTHESIS CLUSTER TRANSCRIPTION FACTOR XANC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="551" mass="60079" checksum="9DC94E4E5CF99F44" modified="2018-11-07" version="1">MIQEERITHPASRDSPRHLSSSSNLSMAAGATVQTPDFSMSSSPEAMARPQGNDNSNEASGGGGLSLRPGRWPRPAEVIDDADDWTQVTDPKEKKKIQNRVAQRSYRQRMKSKVSNLEATVAHYQRLAPPPPTVPSSLGDESAICTSFLSDSTAPFNYRLWSSEPEPSIYSAAMLDSHAFQPPVEREGPLRELGDMIVNHFQLQLKTINRLSESSSSSVVGNGHHPSSASSSPPSPHSPRTSPNLSTLLLPPLRASKSVVLFSSSPPGWLAEAERKADNDSSIDFSLDDGSTTHWGQKSPSDNSLVFPSPQMMSVTDEVTTSPGMAVPPDAMLETRLQAVMKQAEAAGFSSFDQLVVAYYGRPTGGTTTTTTTTTTTTTTATTTMDGGGHPVRNRRLTSVMSQLFQMANCWTPWERSDFHQEMMKMMESVLKTEFTAVRDTLLPQLQPLIDAVDDAGHGSEALVSMKRILHMAVSCRETRAWAEHELIDIAKLPISWELISSLTTESVPMWQQSRSNTAMAVMMLLQLSGYIPTGLLVRLIAASLDDNGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5D2</accession>
    <name>A0A367L5D2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_3660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000015">
        <property type="protein sequence ID" value="RCI09432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5D2"/>
    <dbReference type="OrthoDB" id="2132010at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017008517" description="Hydrophobin" evidence="2">
        <location>
            <begin position="20"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI09432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="15478" checksum="BA9D7AA56EF3E32F" modified="2018-11-07" version="1">MVRIAFATILAVLATSVAAGQGGSQAEATQGVGSGGNGNFGGNGNGNGNGNNNNNNGGGGGGGGGDDDGAAGSQNVGNGQGKQFITGECASKEDCASQCCAARNGGLECAAPGALGVQLGDAECDQSSGGGNGNGNGNGNGNGNGNGNGNGNGNGEAGGQARRRVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5U4</accession>
    <name>A0A367L5U4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_3890</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRM CPSF6/7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5U4"/>
    <dbReference type="STRING" id="1330021.A0A367L5U4"/>
    <dbReference type="OrthoDB" id="10065185at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034772">
        <property type="entry name" value="CPSF6/7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23204">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFIC FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="75"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="11"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="159"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="306"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="16"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="169"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="195"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI09805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="341" mass="35671" checksum="784713856699BF40" modified="2018-11-07" version="1">MADVEFEIDFFGDAANDQQQDGSKVAQNDSQDRDDDASSKTVDQQPEQEDGKAFFQGAKRKPEEDDRPVDPGATTAVMIAELTWWMTDDDVRGWISKAGCEDEIKDLTFSEHKVNGKSKGQAYVEFTSRQAATAAKHHMDQAVADTTQPAQKKVLVSYSGPGINPFRTLPKDAPARGKEQQRLTPSGSYNDRGNHGGFRGRGTFGGGRGNMAQGNFNRNFNSMGYNNNMMGGPMGGVGGGNFGFGGRGGMMGGGMRGGPGGMRGGRGGNMMGMGGPMGMPPMGMPGNMGMMGMGGGMPGFQGMNPGFSGPGFGFGQNPGGGGGGGNGDWGNPHGAKRPRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5Z3</accession>
    <name>A0A367L5Z3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Saccharopine dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_3847</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5Z3"/>
    <dbReference type="STRING" id="1330021.A0A367L5Z3"/>
    <dbReference type="OrthoDB" id="10059875at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004753">
        <property type="term" value="F:saccharopine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000008">
        <property type="entry name" value="Alpha-aminoadipic semialdehyde synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1870.10:FF:000002">
        <property type="entry name" value="Saccharopine dehydrogenase Lys9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1870.10">
        <property type="entry name" value="Domain 3, Saccharopine reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032095">
        <property type="entry name" value="Sacchrp_dh-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF22">
        <property type="entry name" value="ALPHA-AMINOADIPIC SEMIALDEHYDE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16653">
        <property type="entry name" value="Sacchrp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="4">
        <location>
            <begin position="57"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Saccharopine dehydrogenase-like C-terminal" evidence="5">
        <location>
            <begin position="149"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI09839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="473" mass="51350" checksum="DAF0AB22F976C134" modified="2018-11-07" version="1">MASRKVLMLGAGFVTRPTLDILAEAGISVTVGTASPDPHCCFYKPHTSPTNTLQLQACRTLSAAQSLSAGVKNASAISLDVNSDKALDAEIAKHDLVISLIPYTFHASVIKSAIRQKKNVVTTSYVSPAMMELDQQCKDAGITVMNEIGLDPGIDHLYAVKTIEEVHKAGGKITSFLSYCGGLPAPESSGNPLGYKFSWSPRGVLLALRNPASFYQDGKVVDVAGPDLMATAKPYHIYPGFAFVAYPNRDSTGYKERYNIPEAQTIIRGTLRYVGFPEFVKVLVDIGFLKDEEQSYCKEAIPWKEATQKIVGASSSDEKSLIDAICAKTTFPDKGQRDHIVAGLRWIGLFSSEKIIPRGNPLDTLCATLEKKMQYGEGERDLVMLQHKFEVELKDGTKQTRLSTLCDYGSTEPGGYSAMAKLVGVPCAVAVKQVLDGTLSHKGVLAPMSSKINDPLIKELKKYGISCKEEIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6K1</accession>
    <name>A0A367L6K1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_8716</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6K1"/>
    <dbReference type="OrthoDB" id="2428527at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF1">
        <property type="entry name" value="LOW AFFINITY AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="455"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="42"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI10055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="510" mass="53915" checksum="94BDE42B99146D6C" modified="2018-11-07" version="1">MSDSASIQPEPEPEPEPKSESASLPPPRWASQSLTPMREALLVFTTCMAQFCTQSAFFAVLVLLQPVGDSLGVQSRPRLAWLVAGYSLAAGTLIIFCGRLGDVYGHGRMLVVGYAWFALWSCLAGLSVYSGFHLAVVARVMQGVGPAVCLPNALAVLGTAYPPGHRKAMVFALFGAVAPVGAIVGGVFASLLALAWWPWAMWALALWLLVLACLAAAFVVVVDDDDDDDDDDDDDFHDDDRQQNKNPRRFKSVSDALDLPGAVIGISALVLFNFAWTQAPVDGWGKPSVLVPLVAGIVLFALFLLFEMKLSPAPLLPLDAVTADVGFVLAAVVCGWASFGVWTLYLTQTLQDARRLSPLLLTAYFSPVAVAGAAAAVVTGLMLGPLRFGPPTVMTTALSAFTVGSLLTASAPVHQTYWAQIFVAVVVMPLGMDCSFPAATLIVSNAVARRHQGMGASLVSTVVNYGIAIGVALAGTVEMRLQGDPDTVEGRLRGFRAALFVGIVFCTGVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6T6</accession>
    <name>A0A367L6T6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_8388</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6T6"/>
    <dbReference type="STRING" id="1330021.A0A367L6T6"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI10137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="139" mass="16122" checksum="3FFF3605608288C1" modified="2018-11-07" version="1" fragment="single">KTRCKDIRTFSRKKGEFSAFLTNLKNKIRTDKATFRDKEDRIGFLFRSLKGKARKTLETRYDSIERPFSRLAEIIYLLTKTKDDSLSYKDFCGYVKDSAVKRLDAELVLPNDLPALAKYSLLILLPKTPLLNRQIDLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7A9</accession>
    <name>A0A367L7A9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_8654</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7A9"/>
    <dbReference type="OrthoDB" id="5086884at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF11">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="468"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="503"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="545"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="113"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="581"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="581"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="591"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI10316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="613" mass="65189" checksum="B62C1DEF043705C4" modified="2018-11-07" version="1">MAVSKSNQRWSAAAVTTNINNINNNNNNNNNTNKNTNNPAMNKVASLAKRLKPAAAAAAAAASAEESAAGLSPTPVIVSSGEESDGVLVTDHVKLLGRARPAIFSGPLSEVGFVFTVVLSMMTSEYFVGGFDLVLPTIADDLQMPPAARTWPAGVVTLTTAALLQPFARLCDIYGSRLVFLYGQAWLLAWSIVTGFSVNTVMLIVCRAMQGIGAAAFLPAGIALLSHAYRPGPRKNVAFSIYGAFACVGFYFGIFIGALAAELLTWRWYFWIGAIICSADLASGLMTIPRDISDVDPDARMDWLGVLTIVPGLVLVVFAFTDAGQAPGGWRNPYIYVTLVVGVVLLAAAVYVQGWVSTQPLVPPALFKPKYMKRLMLSLFCYYGVFGIFLLYSTFYIENILHIKPLLAAAWFTPLAVGGMILAIGGGLILHVVSNRILLTVSGIGFLLSVLLFALIPGPDEGKSTSFIYWAYVFSAMLGGTIGIDITFNVTNVFITTAMPRRLQAAAGGLINSLLYLGIAFWLGVAETAISATDERRAGGLDAEGQYRIAFWTGVALAGVALCLTVTIRIGQATAGLTADERAEMDRDAAEAEAEAEAEAAAAVEEEEGREST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7E1</accession>
    <name>A0A367L7E1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_4343</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367L7E1"/>
    <dbReference type="OrthoDB" id="5232836at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051037">
        <property type="entry name" value="RNAPII_TF_IWS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010:SF1">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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            <begin position="752"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
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            <begin position="1"/>
            <end position="473"/>
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            <begin position="929"/>
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            <end position="76"/>
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    </feature>
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        </location>
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        <location>
            <begin position="1107"/>
            <end position="1119"/>
        </location>
    </feature>
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        <location>
            <begin position="1289"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1304"/>
            <end position="1358"/>
        </location>
    </feature>
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        <location>
            <begin position="1370"/>
            <end position="1385"/>
        </location>
    </feature>
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        <location>
            <begin position="1408"/>
            <end position="1417"/>
        </location>
    </feature>
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        <location>
            <begin position="1418"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1433"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1456"/>
            <end position="1489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1516"/>
            <end position="1528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI10343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1960" mass="209484" checksum="51693B40773A8114" modified="2018-11-07" version="1">MAPRGRGGKGRAPSQPRATRAKSAAPKSQAADPQAGPAPTGRETRSRQASGSKQTAAGPSKTKTTAGPSNVSSNTRSHSRQPSDHAATRGARTASSTTATTKGSKAGSSTAASSRGNKKTTTKTKTKNAPLTGGSAPKLSEKAKGKRRAVSVSSSDTSDSDRHGRGDKRRRLEEVGGEEDEEDEEDEEDEEEEEEEEEDGDDDEGEEVEEEEEEEYGEDEDAEGEEVEEEQVQQYFGNQQPQRPTPAAPNSQVTGKRKRGGQSGQSQGQSLGQGQHQGQHQGQHQGPGNNNMAPYGGAAPTVVNPYGSLARPTPVPSGNAFNYRQPPAGGLNPSILLSQNPQPGASRGGYQPGSYAGAHQPASSSLPGGTYISPQQWINQPIDHNAPYQTGGNQYGPRQGNQQSAPQSAVQPGGASQPGGQASPSRGSAAAGRGGPSKSKRKRGPGRGGDPDDSDGPQGDDGSPNPPKRRRAKRVCDFCKEAAAARKENPRLPALPPCDWIDMDKFSRECSNCANHRFNNPGSAEHECKISRKPQEHIFRRYADGHPSQYSPNKCERCEAAGFGGYCDADPYLGLSCSGCSTAKNQQECKVGGKVMDRRPNPRQGVEKWFRRQCEGCGNPKSRKNGMGCSWLQDRTGWTNPCVDCAIKGRACIDSGFIVGEIPPPKIPTKWLVSHQLNGAWAEIRGITPWRSGCKECVINGNHCRAMTDTAEFACNRCQQLGIDCFDNNSGILRPQFDISRVGIGIFLPFFACGRCRELKRNCDHQRPCDSCFHRGEEHLCDDPTANQKKTGFFKNRLEPKPGPLYYLGLGYGAGGVDDVKDGSKIEHWIGAPFAMYQMAGRVGETTDAGKMALVSLSERVRNSLKPMQAPPHGGIGGRLAGRQPSSLTVAELEFMLREMWPDIYLMRDHPNYGAIKEDAVQMRRKAIKTEEDDDNDDDDAADDNDPGAGPSTAPAASASATASRGRGGSVRGRGRSRGRGRGGSIRGTSSAPTAHQPQQPQQAEQPQQPQQPQQPQQPLAAGPFPQSSSGALEQAFARNPGQDFLEEQDIQSQLHDSQGLNDDFPQDFGGQDFGGPDLENQGGFQALLSSHHHGDDFQQHPVPHGQNPQPTNSNQGYQQHAHGDHQGIQQPLDPGLEGYQQTQAASGFHQRGNDQRQAGPYPQGMMAQNVPPNQGMPQNVMPQNQAFMGQNPIILQGLPQQSPPQQGVPDPIFQAFPQDVPMPPQQPRVLRYIHFDPTTRMGMLQQLSFATILAISGDRRVQPLVEPHVLQFADTINGMIDATSGTAPPGPPPPGPSPPGAPFNGGGGNGGGSSGPPGGGGPPYGGGGGGGGGGGPPGGNGGGNGGGNGGGRGGGGGGPPPPRNNPFDNDNDDENNNENDENNGNDENHQGDDNNNNNTKKDARQSNNNNNNNNDNPQDQESSSHNTSRATRSSEARRWSAMDDNQTRELLNQADEERALARDEEYEELRRSEGPTRIYEDPREHGDDSENSPVNDENEAPGGGGGGGADEVENRPPPLHPHPAFLPPVGPALQTMGSHARLADPFEPSTAPPHGSLAAVMAASQRLSLAFAAPVSVTRRERRPLGTIQRHAPSPSTVVNSNRTSIESIRWLLSRPNVLVMEHWNSVEAAAERPTPPAARLFNTVNGVEGTSQLPCPGAGEAPVHDELMRIPLVSDDNNNNNNTDDEASATAAHPILCSDPGKDNPQDTVCGTALQPGQACISLDHKGDTSGNGSGVCNSCSQTSIEILNDIDEDPISPQELKAMRAYLCNACSVTFSRLTRETAVQLLQMGAREVYGADIKDPSAATTEDGSDMDLEATIQGQRFKAHSISLPATGCPCATKMFTQRLCRHHRLSYAERATRRARTMSDWRSVAFQGADPCPGCLLAKPASEANLSSSWIRGDKPVAWICMQCNAAVVNQPDRTLVDGFQDWFAVAPPAQWISHTQDMSDPVEIWTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7G6</accession>
    <name>A0A367L7G6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7G6"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="59" mass="6907" checksum="D5C3ADD889273AF3" modified="2018-11-07" version="1">MEEEEEEEEEEEEEEEEEEEEETTQGGIVFAFGRRRKMDASSSHAHKMMQRTKLGSEGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7G9</accession>
    <name>A0A367L7G9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BRO domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_4290</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7G9"/>
    <dbReference type="STRING" id="1330021.A0A367L7G9"/>
    <dbReference type="OrthoDB" id="2141925at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09242">
        <property type="entry name" value="BRO1_ScBro1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09237">
        <property type="entry name" value="V_ScBro1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.560">
        <property type="entry name" value="alix/aip1 in complex with the ypdl late domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.50">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.280">
        <property type="entry name" value="alix/aip1 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025304">
        <property type="entry name" value="ALIX_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004328">
        <property type="entry name" value="BRO1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038499">
        <property type="entry name" value="BRO1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030">
        <property type="entry name" value="PCD6 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23030:SF30">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13949">
        <property type="entry name" value="ALIX_LYPXL_bnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03097">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01041">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51180">
        <property type="entry name" value="BRO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRO1" evidence="7">
        <location>
            <begin position="5"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="786"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="802"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="845"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="914"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="924"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="945"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="973"/>
            <end position="983"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI10366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="992" mass="110123" checksum="654CF3B763239880" modified="2018-11-07" version="1">MTQSPMISAPIKATNEIDWVAPLKAYIRETYGDDPERYAEECATLNRLRQNMRGAGKDSIPGRDILYRYYGQLELLDLRFPVDEQHIKISFTWFDAFTHKPTSQYSLAFEKASVIFNIAAVLSCHGALQNRAEDSALKNAYHSFQASAGMFTYINDNFLHAPSFDLSRECVKALIQVTLAQAQEIFLEKQVADQKKIGLLAKLASQTAYLYAQAAEGVQENVSKAIFEKAWLTLVQIKANLFNSKAQYFQALSDAEAGDHGTAVSRLRVAEGVAKEADRMSRSFPTSVPAGCNLGAETSGILQELSKRQLATVQERLAEEVKDNDFVYHQTVPPEAGLAPIPKLAAAKPIPVSELYAGQDISRITGPDLFAKIVPMAVTESASLYDEEKAKLVRAETEKADTANGEMAAALDYLRLPGALQVLKGGFDQDPEPDEDFRQWCDDVADHENPSAILDWLRSEKESIVSILDRSAKQLDMEESVCEKMRSKYESEWSQQPSARLTTTLRGDIRDYRVALEEAMASDSQLDAKLRQNAGEFDDMRRAAQNGEVDQLYQRAVAAARGKGGSVSTTSSAPEPNLLDADFDDGEFSVADQVAKVEDLVKKLNLVKRERNQVLKDLKEKVHNDDISQVLILNKKSISNYEAQLFEQELGKFRPHQNRLLQANHKQSALMKELMTIYNALLQDKRVRSERSKYEAIQRQTSTVVNRYKRAYQEFLDLEAGLQSAKNWYGEMRETAESLEKNVETFVNNRRSEGAQLLNQIEQDRSVSKSNQAELERERLRGLMERMSMEPAKSPPRPASGPSPLLLSSQPGSMGSAARYPQVNFQGHYQVPTSPPPPPHQAGNMQQQQQQQQQQQQLQQALHMQQHQHPYPAYGGYSSPAAASGSFSPPTYNPSQYGPTAGPRSPPATQTSFGQQAARPYQAYGGGPPQQPQGAGGGGPVPHGFVPPPPPGPPPLGPQQTIHYGKHKFEVPSSAQAGQQPQDPWTELDAWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7M1</accession>
    <name>A0A367L7M1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyltransferase family 25 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7M1"/>
    <dbReference type="STRING" id="1330021.A0A367L7M1"/>
    <dbReference type="OrthoDB" id="47375at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="458" mass="51517" checksum="D704E537E72582B2" modified="2018-11-07" version="1" fragment="single">MRRLKSANLNPNQAPRRLPPQAATKFITHFQQQKKKKKRPAILRVHVHDWPAAHTTMRPRKAHVRLRATKAVILVLVCCSVWLLTSQLVRRAGPFSSASSSSSSLLSFSSLFPSPSSPSPSSSSNSTLGFGRIYVVSQQDSPRRKTIIQAANVTELTLTIPLQPVWTDQDERKFRLPKDSSIQRGSLLAWLGHLHALQQFLDSGAETALFLEDDVDWDIRLRTSQAPLVSAAARRLLAVDDGRRYPYGHPDRWDLIYLGHCGDYWHGMDVEFVDGHVKPSDLSSTPHAAFADHSMSPPHRLHPFTASLFKNLGVGPQTRLFHRSVFPLCTFGYALSRAGALRLLQLGRKEPSTSGHKAYDVLILLSCRDYGLRCWTVNPEIFHHMPGPSIIDVQQGNTELPPVDRAAKDQIKDRGETPNIDCGFWDGSFRFDDGDVTRLDWLRREVGRKGRCLKKGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7P2</accession>
    <name>A0A367L7P2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_4270</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7P2"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI10431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="93" mass="10807" checksum="65647B19A9D7BAF6" modified="2018-11-07" version="1">MLIILPSSTLTYLYKIGDLEEDLYVPYPAVSAVLRGVEEEEESRDGLKEAIEEELEAGEVFVLRRYFSRYFKVPTCSTLTYLYVRTLPRFPCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8U9</accession>
    <name>A0A367L8U9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8U9"/>
    <dbReference type="OrthoDB" id="4914391at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016562083" evidence="1">
        <location>
            <begin position="36"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="368" mass="41759" checksum="804DA27CDFEB7A5E" modified="2018-11-07" version="1">MLCVSAICCFHVNQPSTMMKFKLLISVASAMLALAEYDVPPELHLDDESFQEIFERLSKIDTSNIPYFNSSQSVSKPCSRLGTYSWPLGGRKCCPKIHYWVEEELIPGSVNIMATPQINIEADVSANGSSVLFNTSQTTVIFDYDAEGWSLDVQPKSHDLGNLFTRGKIQPRAHRERETIKQTTEYHCPAWHDCQVQVLSWHATVLGKCKSTAKFACSRELRMCDQKKEDLRCEASQRYYDQHCHGDRSRACGFTVPLFGQSGMPRSEINMLTRDRRPHFTGCFKGFPWATLSNGEVYNPVDDSYFVHSSGVSRWYTKDRSEPPPLMPREFPCPRPQATNLESLRDCTDAACQQFRDDSLVREHAGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8V7</accession>
    <name>A0A367L8V7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial distribution and morphology protein 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Mitochondrial inheritance component MDM10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MDM10</name>
        <name evidence="11" type="ORF">L249_5266</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the TOM40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of TOM40 with the receptor TOM22 and small TOM proteins. Can associate with the SAM(core) complex as well as the MDM12-MMM1 complex, both involved in late steps of the major beta-barrel assembly pathway, that is responsible for biogenesis of all outer membrane beta-barrel proteins. May act as a switch that shuttles between both complexes and channels precursor proteins into the TOM40-specific pathway. Plays a role in mitochondrial morphology and in the inheritance of mitochondria.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. Associates with the mitochondrial outer membrane sorting assembly machinery SAM(core) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Mitochondrion outer membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="8">The ERMES/MDM complex localizes to a few discrete foci (around 10 per single cell), that represent mitochondria-endoplasmic reticulum junctions. These foci are often found next to mtDNA nucleoids.</text>
    </comment>
    <comment type="domain">
        <text evidence="8">Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the MDM10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8V7"/>
    <dbReference type="STRING" id="1330021.A0A367L8V7"/>
    <dbReference type="OrthoDB" id="2103793at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032865">
        <property type="term" value="C:ERMES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001401">
        <property type="term" value="C:SAM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051654">
        <property type="term" value="P:establishment of mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070096">
        <property type="term" value="P:mitochondrial outer membrane translocase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990456">
        <property type="term" value="P:mitochondrion-endoplasmic reticulum membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015914">
        <property type="term" value="P:phospholipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03102">
        <property type="entry name" value="Mdm10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027539">
        <property type="entry name" value="Mdm10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28035">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28035:SF1">
        <property type="entry name" value="MITOCHONDRIAL DISTRIBUTION AND MORPHOLOGY PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12519">
        <property type="entry name" value="MDM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 8" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="474"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="517"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="627"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="652"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="688"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="719"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="760"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="308"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="566"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="597"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI10846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="780" mass="84633" checksum="E78F2A517CE4B002" modified="2018-11-07" version="1">MREFMELVHGAFYEATGWRRDNSYAALNATPDALLDFATPRGLRLTLSSLATTNFASSYQLGSVGVVDGSIAYLFSSVPLRLDLACAASLRRLLRAYRPLEPLVPTASPPFHSSSLLYGRLYLPQSRLEALAVRRVSAALQLQLSAVSDRALRDGGTVLGLAQYDVGRYSFDGIGSTDGGLLGLRGVYNFGDDELRTTQQQRSQSTERERIYGRFSTGAEIYYGTLNKSGGISIGSRFATLPSYGGTPLSATLTINPLMGNVSASYAVGAGENCSLATRMEFNVFSYESAWAVGMELWRKPFRRRSTFGDDDDDDDDDDDDDDDDDDDDDGMKMRLRLPPERSWQAKLAWKQDEDDRQQRLGGVLKARLDQKLRIGLVWEGRLKSLLFSLGSGIDLGRLDRPFRTLGLEVQFSSAHNDDGPHEAGEDCHAGPVAIGKLPLRIGAIFILLVLTFITAVVPWMVSSKTQNNAAARAAMFIFKYVGTGVIIATAWMHLLAPAVEQLGNECVGHVWPVMAGYPWALCIGLMTIMAMSLLELVVSSMTNDDDGLGRAVTIAGSCDSNDMLTRKKSVVDDEDEARTGSPPRTAVEADNEKQQQHSSLQQQGIRDGQRGGGGGGGFAGQVSAMLMLEFGVVFHSVFIGLTLGTTTDDKFNMLLVVLVLHQMLEGLGLGSRLAVTSWPKSKDWVPWVLALGFALSTPMGMVAAISTKPPSQMATQTLINGIFDAISAGILMYTGLVELLAKDLFFDPAMKRARLGRKLAVFGCVAVGVFAMALLAKWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8X6</accession>
    <name>A0A367L8X6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Vta1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_5206</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the VTA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8X6"/>
    <dbReference type="STRING" id="1330021.A0A367L8X6"/>
    <dbReference type="OrthoDB" id="391137at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.420">
        <property type="entry name" value="Immunoglobulin FC, subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.270">
        <property type="entry name" value="Vacuolar protein sorting-associated protein vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044538">
        <property type="entry name" value="Vta1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039431">
        <property type="entry name" value="Vta1/CALS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023175">
        <property type="entry name" value="Vta1/CALS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041212">
        <property type="entry name" value="Vta1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46009:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VTA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04652">
        <property type="entry name" value="Vta1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18097">
        <property type="entry name" value="Vta1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vta1/callose synthase N-terminal" evidence="10">
        <location>
            <begin position="13"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Vta1 C-terminal" evidence="11">
        <location>
            <begin position="310"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="155"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="162"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="205"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="244"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="261"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="296"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI10880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="37604" checksum="B1CF91ADD1C060D0" modified="2018-11-07" version="1">MEPLPAGLKIPEVSRFINRANQLRSIKPALAYWCEYHAVNQIVGRSLHTTDDACFAFTKTLIESLEAVKAERADDDAIVDNDAGQAYVEQFANETFARAERALRADKVTRQTADTFDAAATFFDLTREWGTPDAETLQKIKFAKWNAARILKAIREGKDPNESNPAKQPSADQQVQLSPDDPSVRQIISPPPPAAVDGDEPAVAVDHEHSAAEAPPRDEGGYFPPVPSDAAVPAAGQGPVSFAPSDPMSTSPPTTQTDNPQFPPGPSAPPPQFMPSSPSFRAVATSPPAFSPPPQATSSVAPRASMTSQRDINDAQKHAKWAISALNFDDVPTAVKELRNALQKLGSPLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L991</accession>
    <name>A0A367L991_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5354</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L991"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI10974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="115" mass="12102" checksum="9DE4E90980C1A7B7" modified="2018-11-07" version="1">MAPGKGLTQASAWEAGHSADGIFGYPGSPSPHNGTKAVRLLIEKGKNEKKPPTLPKSVASVCDSSQIPPPANHGSFLFLYRACAMITTTCPAPSLTGNITTSSICVWMDMMASFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-05-03" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L996</accession>
    <name>A0A367L996_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5411</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI11000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L996"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI11000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="82" mass="9100" checksum="20F20C2CF90DF289" modified="2018-11-07" version="1">MQFEDGEGGNRLTECEASHVQWINKKVREDSTGSTGNGTTPGGYFWLGLRAHNRHQETSLLSLNSKLAVKRLDAELVLADTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9H5</accession>
    <name>A0A367L9H5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9H5"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="113" mass="12370" checksum="A028B4B632C4019E" modified="2018-11-07" version="1" fragment="single">PKARHNALSHSGAIAVIAPDRLVIAIGALQPSHRSARCTNSGHSARSVVTAVITVIVTAIDALFNFITSSIQSPLLPSILLQSSQNHHHVIRLLLLYHVIHTLITHYHFHCRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9M7</accession>
    <name>A0A367L9M7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fungal lipase-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_7280</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9M7"/>
    <dbReference type="STRING" id="1330021.A0A367L9M7"/>
    <dbReference type="OrthoDB" id="438440at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051299">
        <property type="entry name" value="AB_hydrolase_lip/est"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640:SF1">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016669742" description="Fungal lipase-type domain-containing protein" evidence="4">
        <location>
            <begin position="32"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="5">
        <location>
            <begin position="105"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI11127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="397" mass="44226" checksum="F6045D002ADB508D" modified="2018-11-07" version="1">MTKLARSFIRPSPQWLLVLLVLLVLLPLSTSRIPTSLWTDLERLSRIADIAYCVGTSGVRKPFRCLSHCSDFPDLSLATTWHTGMLLSDSCGYIAYDASTSSILVVFRGTYSVANTMVDLSSVPQPYMPYPPSTAPDDEDDNDGRRRRRRRFQCENCTVHTGFYQSWLNARHLVLPEVKTLRELHPSATIHLVGHSLGGAVACLAALELIVSVGFRDVRVTSFGEPRVGNGGMARFVDSVFNLVVEEDHQKGQGEAEDKDEDVKVQEEEEFRKDGSSYRRVTHFQDPVPLLPWDEWGYSSHAGEIFISKAGLSPSEEDLHPCFGDADAECSTALLGRQTGAAAYRSRALLSSSSPISPWPPLFAHRDYFLRLGLCVPGGDPANWARRERQEKQPDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9R9</accession>
    <name>A0A367L9R9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="2 12">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L249_7494</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD(+) = N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="10 12">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="12">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="2 12"/>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9R9"/>
    <dbReference type="STRING" id="1330021.A0A367L9R9"/>
    <dbReference type="OrthoDB" id="361797at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000001">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000025">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050151">
        <property type="entry name" value="Class-I_Pyr_Nuc-Dis_Oxidored"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912:SF151">
        <property type="entry name" value="DIHYDROLIPOYL DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912">
        <property type="entry name" value="DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 10 12" id="KW-0274">FAD</keyword>
    <keyword evidence="3 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 10 12" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 12" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="14">
        <location>
            <begin position="47"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="13">
        <location>
            <begin position="392"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="490"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="187"/>
            <end position="189"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="224"/>
            <end position="231"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="364"/>
            <end position="367"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="11">
        <location>
            <begin position="85"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCI11156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="511" mass="55059" checksum="8C2BD59ABA707788" modified="2018-11-07" version="1">MLTCRLLTRTVFRPLPLKQSSFSPVAVSSWNSWSRWSRGFASVSEEKDLVIIGGGVAGYVAAIKAGQEGMKVTCIEKRGTLGGTCLNVGCIPSKSLLNNSHLYHQILHDTANRGIEVGDVKLNLAKFMKAKDTAVTGLTKGVEFLLKKNGVEYLKGEGSFVNENDIMVNLNDGGETTVRGKNILIATGSESTPFPGLEIDEKRVITSTGALELKEIPKSMVVIGGGIIGLEMASVWSRLGSKVTIVEFLGQIGGPGMDTEIASNALKLLKKQDMEFKLKTKVTSGDTAGDMVKLQVEAASGGKAETLEADVVLVAIGRRPYTQGLGLDKIGMELDERGRVIIDSEYRTKIPHIRCVGDVTFGPMLAHKAEEEAVAVVEYIKKGYGHVNYGCIPSVMYTYPEVAWVGQSEQDLKNQKIPYRVGTFPFSANSRAKTNLDTDGMVKMLADPETDRLLGVHIIGPNAGEMIAEGTLALEYGASTEDIARTCHAHPTLAEAFKEAAMATSSKAIHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9W6</accession>
    <name>A0A367L9W6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitochondrial presequence protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_7642</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9W6"/>
    <dbReference type="STRING" id="1330021.A0A367L9W6"/>
    <dbReference type="OrthoDB" id="4953at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000015">
        <property type="entry name" value="Putative zinc metalloprotease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000031">
        <property type="entry name" value="Putative zinc metalloprotease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016:SF16">
        <property type="entry name" value="METALLOPROTEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07610)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016">
        <property type="entry name" value="PRESEQUENCE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="2">
        <location>
            <begin position="60"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="3">
        <location>
            <begin position="198"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1016"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1023"/>
            <end position="1056"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI11221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1056" mass="118277" checksum="8C084757AEC7F220" modified="2018-11-07" version="1">MPADTLKSRFRKVQSFETDYAPCTITQYVSERSGMSVVVADRKGPKINGYFTLATEIFDDSGAPHTLEHLVFMGSRSYRYKGLLDKLSSRAYSSTNAWTATDHTAYTLETAGWDGFSQVLPVYLEHIILPVITDDAIVTEVWHVDGEGNDAGVVYSEMQAVQFRSSEIMDLKARRHLYPENVGFRYETGGMTDALRVLTPDRIRQFHRDMYQPRNLCLVIVGEADHADLLRILDEFEESIAEDIPPLSAPFKRPWIDSSQPSPLRETVVTTAEFPEEDESVGEILVGFFGPNCIDMVATSALNVLLTYLCGSSISILENVLVEREELASSITHYWESRPNSVIWLQPTGVATEKLEMVERRLFELLKEVAAKPIDMDYMTDCIHREKRQVKLHAETSESFYATNIITDYLFGKRDGSTLRDIETLKEYDDLEQWTDEEWRDFLSKWMADAHHISILGKPSHALAARMKSDEAERIAKRKEELGPEGLQKLGKRLDEAKQNNDVTIPAEVLERWSVPGTESIHFIESDTARSGPARSVGLGQGEAQVRIDAAGDGGGERPLFIQFEDVPTSFVHITIHVGTSRVPVELKPLMPIFSDNFFNTHVMQEKLVNFEQVVREIERDSVGYGISSARSLGDPDGLMIQFQVEPDKYRVAVDWLRTMMFDSVFDPSRLRAAVIKALADVPEGKRDGRGMASEVDAAIHLDKSSLSVAKRVLVRAVYLKRLKKMLRDDPDKVVSWFETIRRSLFTSHNMRFLVTARLQGLAEPVATWDCLAKVLPRGDEDMVPIPKQVSLLNQEGSNPGSFGAVVIPMTTLDSSYSVSSARSISSLSDPRFPAIMVAIGYLESVEGPLWNAVRGRGYAYGSFFSRSFDSGIISYRVYRSPDASKAMAASHDAIRAIAEGQVPIDRHLLEGTMSQIVVMIADEQATMPSAAQQNFVQGVVRGLPRDWNKDILRRVRAVSEHEMKAAMTDFILPCFQPGKSNVVVTCAKLMTEGIESALKAVGYKVQTRELSYFHDDYGLEAGDGDDEEEEEEDEEDEDGDESMDASGDDDDEDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LA57</accession>
    <name>A0A367LA57_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_7204</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LA57"/>
    <dbReference type="STRING" id="1330021.A0A367LA57"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03755">
        <property type="entry name" value="proteasome_alpha_type_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000004">
        <property type="entry name" value="Proteasome subunit alpha type-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 3 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="6">
        <location>
            <begin position="5"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="237"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI11296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="269" mass="29229" checksum="8C7C5186BD4CAD0C" modified="2018-11-07" version="1">MASGYDRALSVFSPDGHVFQVEYAGEAVKRGTCAVGVKGKDVVVLGCEKRSAMKLQDTRITPSKIQVLDTHVALAFAGLNADARILVDRARVEAQSHRLSVEDPVTVDYITKYIAGVQQRYTQAGGVRPFGISTLVVGFDPGSQVPRLFQTEPSGIYSAWKANAIGRSSKTVREFLERNYKEDMDREATIRLAIKSLLEVVQTGAKNIEIALTAPGMPLLMLPTEEIEGYVKEIEQEKQEEAAKKKTGRGPGTGSAAIPTRAQDDSTTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAX9</accession>
    <name>A0A367LAX9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAX9"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="177" mass="19691" checksum="88DDAF902F73C6C6" modified="2018-11-07" version="1">MGGRKRELSQPSTEDSLSLSSLHGATVPARAGRALKGRGQDEVAKDVQGFDPFFFIDSRTLSLLSTSISRLTHLVVSCIQLPMYGWMHLVSGIGKLEGGRSRKEDNQGRTNQQRDKGKKNNAITDINNPVRPPSQKQQKQHTWERKKASVVRNGHTSYGPYIHVYKTFSPSPPPRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LB43</accession>
    <name>A0A367LB43_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_7198</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LB43"/>
    <dbReference type="STRING" id="1330021.A0A367LB43"/>
    <dbReference type="OrthoDB" id="3145928at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF11">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="55"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI11462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="479" mass="53841" checksum="F62253160E5587F8" modified="2018-11-07" version="1">MVGVPGKYKGCETCRRRRVKCSNERPFCKNCVNNGRQCEGYERERVFITGTLETKGRVASHPKRAGSTSKHRSKAAAGVRATSKPQIVPTRPLTSAWDDSVTLSGEGVEASVRMTALQTSLQNVVDRRTDDHAGISLSLPPFVAPELQPQAGELNAKARCLVRMGGVYDAHDLTDGYCAFLFEQGQCHEPPNNCAEPWDSHSQQASLVKRLGPKSFTTFPNHQYFVSLALLGRRDCFLSEQEWMTTPWTGHPKSPLDRLFDVVLRLPSMLATADDLLPLAATMTRRIRAQDLLQECLIIEMHLHEWLQSVTTGAEGQHAPYWSQEESGGEIPFANPYAFRDGLAALMMLYYWMALIPFHRCIDSLHEAIFQPVVDAYPNMWPDLPPNLQIDPSQYQDGRELAANICRGLNAALDTTTQPDILVAPMTMAMDFYRNINATLQDGVLEILWLEAFQRKLAFKVQYIAGVLQQQRWVEVARY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LB47</accession>
    <name>A0A367LB47_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SAM-dependent methyltransferase TRM5/TYW2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_7234</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LB47"/>
    <dbReference type="STRING" id="1330021.A0A367LB47"/>
    <dbReference type="OrthoDB" id="408788at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070901">
        <property type="term" value="P:mitochondrial tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.110:FF:000001">
        <property type="entry name" value="tRNA (guanine(37)-N1)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.110">
        <property type="entry name" value="Met-10+ protein-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03152">
        <property type="entry name" value="TRM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056743">
        <property type="entry name" value="TRM5-TYW2-like_MTfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056744">
        <property type="entry name" value="TRM5/TYW2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025792">
        <property type="entry name" value="tRNA_Gua_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245:SF36">
        <property type="entry name" value="TRNA (GUANINE(37)-N1)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245">
        <property type="entry name" value="TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="TRM5-TYW2_MTfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25133">
        <property type="entry name" value="TYW2_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase TRM5/TYW2-type" evidence="10">
        <location>
            <begin position="143"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI11643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="461" mass="51262" checksum="1019A89713C08CAE" modified="2018-11-07" version="1" fragment="single">QGQADEALSRPAAARAATTLDRSLFSRSVPTAAASVRDNRLISKYRKPLAGTRELLQFDKFDPIAPDPDPALAAQGRKCFILQPDVKPAEPETWSPVLREASELGDLSLVPTEVTIDYDMWSYLDVVRALLPEELHDEIPVGFNTAGHVAHLNLRDRYWPYKHMIAQVILDKNPAIRTVINKTDNVGTENEFRTFSYEVLAGPDNMMVDVSMAGCVFHFDYSKVYWNTKLGNEHQRIASLFRPGEVVADVMAGIGPFAVPAGKKGVFVMANDKNPESYKYLDEAIRRNKVAQFVRPFNQDGHDFIRNAAKLVLEASRRGDCALIHAAKVRRGTPQQPPPPPPRRVPMPPTISHFVMNLPASALGFLHDYRGLYRGHEELFAPHTDMQLPMVHVHCFAAKADGAGPLDDICRRIYDEIGVGLVPGDADVRGHVSIEEVRDVAPSKRMFCASFRLPPEVAFAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBG4</accession>
    <name>A0A367LBG4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7381</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBG4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI11770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="157" mass="18156" checksum="0A91DEBFFC3E0050" modified="2018-11-07" version="1">MLRRPKRKPLPPSSLFDGDKTLFLARDIPYNNYARAVTRIRSIAINIEAFCLKAYSNAKRAPLASKTRLRPNTLITDIYSVSSDIIKQRCVDSICLCYSVPRHFLKSCNLYPAYCLFILRIRFIDILMRYNVLVRASRRELIIYSADNLVIYSSAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LC97</accession>
    <name>A0A367LC97_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_0539</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LC97"/>
    <dbReference type="STRING" id="1330021.A0A367LC97"/>
    <dbReference type="OrthoDB" id="605656at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000001">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056263">
        <property type="entry name" value="RPN11_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23594">
        <property type="entry name" value="RPN11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="9">
        <location>
            <begin position="33"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="306"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="306"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI12031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="330" mass="37184" checksum="F251BDE17E2719DE" modified="2018-11-07" version="1">MDRFRSLLGGGMGLGGAAHGTDNTNLIDNSETVYISSLALLKMLRHGRAGVPMEVMGLMLGEFVDDFTVKVMDVFAMPQSGTGVSVEAVDPVFQTKMMDMLRQTGRPESVVGWYHSHPGFGCWLSSVDINTQQSFEQLNPRAVAVVVDPIQSVKGKVVIDAFRLINPQLLMMGQEPRQSTSNLGHLNKPSIQALIHGLNRHYYSIAINYRKTALEENMLMNLHKHVWTEALQMDDFRSEGNKNKERLQRLVSLADGYEKRVKEETELSKEQLKTRYVGKLDPKKHLEDVGQEIIEDNIVSVSRQMIDKEATMPKKEDRQPSLNVDQMDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCM5</accession>
    <name>A0A367LCM5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_4585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000008">
        <property type="protein sequence ID" value="RCI11982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCM5"/>
    <dbReference type="STRING" id="1330021.A0A367LCM5"/>
    <dbReference type="OrthoDB" id="5545479at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28139">
        <property type="entry name" value="UPF0768 PROTEIN YBL029C-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28139:SF1">
        <property type="entry name" value="UPF0768 PROTEIN YBL029C-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI11982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="101" mass="11573" checksum="AC6079F32C87B971" modified="2018-11-07" version="1">MFFFFFCGEHNFRKDVRGYEGIVCQCHHCGNMAGHVIKSFPWFTICFIPVLPFTIKGYTDVTCNICNFSQPLDTRPDVVAMAQDARPPQYTSEPPSHQTYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCU3</accession>
    <name>A0A367LCU3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor 38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_0758</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PRP38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCU3"/>
    <dbReference type="STRING" id="1330021.A0A367LCU3"/>
    <dbReference type="OrthoDB" id="190958at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005037">
        <property type="entry name" value="PRP38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23142">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03371">
        <property type="entry name" value="PRP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="204"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI12235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="235" mass="26625" checksum="9318C93BC845B0D0" modified="2018-11-07" version="1">MAHPSVTVPGARHFLDTRGTTATLAPNGLNPATIMEKAVRDRITNSYFYQEQCFFANEADVVESVVQHVSFIGGTHGADQKPSPFLCLAFKLLELAPGDDVLAEYLAYGGEQFKYLRALACFYVRLTRPAVDVYKMLEPFLADRRKLRRRRREDCYLSFVDDFVDQLLTKDRVCATSLWKMPQREALEDAELLEPRVSPLGDLDALLEEDSDDDDNSGKHHDDEDEAEKDNDNDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LD93</accession>
    <name>A0A367LD93_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_1121</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LD93"/>
    <dbReference type="STRING" id="1330021.A0A367LD93"/>
    <dbReference type="OrthoDB" id="4927449at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016737179" evidence="2">
        <location>
            <begin position="19"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="417"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="453"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI12403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="549" mass="56252" checksum="C29321817DAB4D06" modified="2018-11-07" version="1">MNKCTSVLVGFAAIGAFAQLDSGSKVPETPGFGDACHQNGYPDGYPAKYYPCNEVVEYTAACNGINDLVKHRNCICEPYLRAVEEGCLKCKQAHGLHSKNEDKYWKEMLESTLAAYCKMGNPTVTYPVHWQGRRTKKGDPPLPGAEGDDERINSLGGDVSPERYMTEFPAKPDMSKYGPVPTGTVPVEPSRVLVVATQTASADGVTASASVSIPKYPTNGTSSSFEASVDAKVSLHVVGFDVKANVTNEGVKWQSSSPYYVPNAKVEAASIVKISAKARVNIVDGSFCGCIPKTVACGQSVVVDGKVKAKACYTALKPSADGKELVVDEKRTSDKPLPGAGPISISASASVGVVPYYPAPAICRPECNKAEAHVSVSPAGVHAKASVCVVVAAQGDSKVYVPAAYVKNDAVVPPGAPAPLPNTVPEAPAGSSKSHKTAPGSGPAAPAKDSRPDSSNPSPADGSSPASGAESADSPARPASGGAKSADSPARPASGGAKPADSPVRPVGTGLPIPPASVPQKPEAEVFKGAAAMNLPSMALAAGLLVAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDC4</accession>
    <name>A0A367LDC4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_0454</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDC4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI12411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="191" mass="21205" checksum="9BC3DD3980CB471E" modified="2018-11-07" version="1">MDAVPSLQVSKVNPPSQLHTVKKKKKLHGQHVILPHTPQSIISPFERRREGGLLLHLQPFPFPIPKPSSSSPYIKSYQNVFPPFPTASSYPPPPPISRRLRRTSSSPYLSSSYVCTCICFHPSQTGATGSLGPPSTPLEMGSSIALEICDRCFRDRCFVYQASRELRFSFHFLFLPSHSSSSGKPIALSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDF9</accession>
    <name>A0A367LDF9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_0433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDF9"/>
    <dbReference type="OrthoDB" id="10602780at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI12459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="148" mass="16168" checksum="F5531E7359BF429F" modified="2018-11-07" version="1">MPQLFGNRGSSTHSESLSQYCGLIRKPPQEGYLFWQVPLHLSRSAQLGEEGTQMVSLGQGAIFRPHGRPAVSACAAASAWAAAKLAKAVARARMVRGRRTEKPECLVPDNGALAVFQPRLSRILQDNHKDYCVEKVCVRGVSLSTELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDW6</accession>
    <name>A0A367LDW6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="2">1.11.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_0647</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="2"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDW6"/>
    <dbReference type="STRING" id="1330021.A0A367LDW6"/>
    <dbReference type="OrthoDB" id="185659at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03015">
        <property type="entry name" value="PRX_Typ2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000003">
        <property type="entry name" value="Peroxiredoxin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050217">
        <property type="entry name" value="Peroxiredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF171">
        <property type="entry name" value="PEROXIREDOXIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681">
        <property type="entry name" value="THIOREDOXIN PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="3"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="10">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI12618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="214" mass="23432" checksum="56D202C6992C58A2" modified="2018-11-07" version="1">MSAFVQKPAPAFTAQAVMPGGEFKDVSLADFKGQWVILLFYPLDFTFVCPTELVEFSDAMERFRKINTTVLGISTDSAFSHLAWVQRPRSQGGLGPEMQLPLVADKSLSIAKDYGVLLEKQGIALRGLFIIDPKGIVRQVTVNDLPVGRSAVEAIRLVEAFQFVEEHGEVCPAGWNKGARTIKADPKGSLEYFAAAHGEKTNGNGESHKRPRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEU3</accession>
    <name>A0A367LEU3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">HMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L249_1320</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEU3"/>
    <dbReference type="STRING" id="1330021.A0A367LEU3"/>
    <dbReference type="OrthoDB" id="432719at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd02094">
        <property type="entry name" value="P-type_ATPase_Cu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000001">
        <property type="entry name" value="ATPase copper transporting beta"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006122">
        <property type="entry name" value="HMA_Cu_ion-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00003">
        <property type="entry name" value="copper ion binding protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF8">
        <property type="entry name" value="P-TYPE CU(+) TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00942">
        <property type="entry name" value="CUATPASEI"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01229">
        <property type="entry name" value="COF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0187">Copper transport</keyword>
    <keyword evidence="13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="401"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="449"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="478"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="666"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="708"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1058"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1087"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="16">
        <location>
            <begin position="28"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="16">
        <location>
            <begin position="115"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="16">
        <location>
            <begin position="200"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="16">
        <location>
            <begin position="282"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCI12945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1168" mass="122732" checksum="4303D8B1C13FAD35" modified="2018-11-07" version="1">MAPLIIAIPPPASDGARLAVSSGRPRMATTTLRVGGMTCGSCTSAVEAGFKGLIGVRSVSVSLVMERAVVAHDVDVISAEQVCEIVQDRGFEASILSTDMRSPVVKSFSDRAQLASTTVAIEGMTCGACTSAVEGGFKGVPGVESFSISLLSERAVIEHDPALLTAEQIADIIEDRGFGARIVATAASVALSHNTSGTVATTTVAIEGMTCGACTSAVEGGFKNVDGVLKFNISLLAERAVITHNTTKLSAEQIAQIIDDRGFDASVVSTIFEDRDQGDSLNTAQLNVFGKPDAAAASTLEETVRALPGVMAASLSLATDRLTVTHQPAVIGLRAVVEAVEALGFNALVADGQDNNAQLESLAKTREINEWRSAFRTSLSFAIPVFVIGMVLPMFLPGLDFGAWALVPGLYLGDVICLGLTIPVQFGIGHRFYVSAYKSVKHGAPTMDVLVILGTSCAFFFSLLSMLVSLLVPPYSRPSTIFDTSTMLITFITLGRYMENRAKGQTSKALSRLMSLAPSMTTIYADSIAVEKAAEAWAKSPRGPMTPTTPRLMTGSGASAYEEREIATELLQVGDMVIIRPGDKIPADGVVVRGETYVDESMVTGEAIPVKKRVGDSVIGGTVNGNGRFDFRVTRAGKDTQLSQIVRLVQDAQTARAPIQQLADTLAGYFVPTIVVLGLCTFVAWIVLSHVLPHPPQIFLQNASGGKIMVCVKLCISVIVFACPCALGLATPTAVMVGTGIGAENGILIKGGGALERTTKVTQVVLDKTGTLTHGKMTVARTTMATPWAANDWRRRLWWSMVGMVEMGSEHPIGKALVDAAKREVGIEPEGAFSGSVDEFEVTVGKGVKALVEPHSTPAVGYRVLAGNVGHLQANGVEVPREAVVASEELNAAASNNKKGDEDNSGTTNIFVAIDGQYAGHVCLADTIKDGATAAVAVLHRMGVKTAMVTGDQRSTALAVAAAVGIAGCDVFAGASPDQKQAIVRQLQARGEVVAMVGDGINDSPALATADVGMAMASGTDVAMEAADVVLMRPSDLMSVPAAMHLTRSIFRRIKMNLAWACLYNVLGLPVAMGFFLPLGFHMHPMMAGFAMACSSVSVVVSSLLLKFWSRPSWMMADAGGDDVAAALPSRFGLWQAWLLRLRRPRAAVVAADAGYVPLQDLDVENGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEV5</accession>
    <name>A0A367LEV5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Plus3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_1047</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEV5"/>
    <dbReference type="STRING" id="1330021.A0A367LEV5"/>
    <dbReference type="OrthoDB" id="166375at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990269">
        <property type="term" value="F:RNA polymerase II C-terminal domain phosphoserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.200">
        <property type="entry name" value="Plus-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004343">
        <property type="entry name" value="Plus-3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036128">
        <property type="entry name" value="Plus3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13115">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13115:SF8">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03126">
        <property type="entry name" value="Plus-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00719">
        <property type="entry name" value="Plus3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159042">
        <property type="entry name" value="Plus3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51360">
        <property type="entry name" value="PLUS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Plus3" evidence="6">
        <location>
            <begin position="235"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="132"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="438"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="178"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="448"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="511"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="546"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI12762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="582" mass="64646" checksum="8F7559DF048F5045" modified="2018-11-07" version="1">MADIDDELLALAGGDSEDEGSPRDASTSPGRTELAKNTKRRNSGDEEEATSMPGTPNSLESAPMDESDSDAEQPAPRNGGGEGDQKYPVDGMFASQAEKAEIMALREVEREQIIADRISEIERQRQNRLLRQMVTSVENEERKHVKKKRSADAADLDDGDRLASRQRTGKVSETAMDSLRRAKAEKQRRKEDQDRRKDALSPRRDTAGQAESDHDFDRVRSRTPQDDGEAKGLPPPELHDYDRVRLGRNEFAQVCSTPGFDTTITGCFIRLAVGTHPETGIPQYRMACIKGFATGKPYAMSGPNGQFVTDQYIKAAHGKAIREFPFIATSSGKLTDAELNRYVITCRNEGVSLPTKQSLVDKIDDINALINHSWTSEEIKARLARRTELKRLFDPAQRERLGRLLDEAVARGEENKVEELQQELAELSGHRLAFRTTLGAARGGETAKSSEQDRLAERNRENRRMNVEQVRRAQLKEKAKTRGGGGGGGDDGSRRPRIKSAKSAEDERQQQHQGQGQQQQQQQQQQQQQSSAAESAAKQMASHLAKLQEKKHGDGKGLPTIHKPLMDDEVIGALDLEIDVEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEV8</accession>
    <name>A0A367LEV8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_0105</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEV8"/>
    <dbReference type="STRING" id="1330021.A0A367LEV8"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000001">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF3">
        <property type="entry name" value="AMINO-ACID PERMEASE PB1C11.02-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="452"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="62"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI12950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="554" mass="60563" checksum="C798D9E1AF4183C9" modified="2018-11-07" version="1">MASKHKQAQSEASTPTLHRKRPDDDDDDDAGDRKKREDEDAEEGLVFAHSDRLKRSLSARQVQMIAIGGTIGTGLFLGSGKSLAAGGPASMLLCYAVVGAIVFVTMLSLGEMSAFVPVAGSFCTFAGRFVDDAFGFALTWNYWFNDAVSTAADLVALQLVLQYWTERFPGWALSLIFWFVLVGVNLATVRAYGELEYWLSLLKVIAIMAFIVVGIVVNVGGNLDGRYIGGDNWRLPGGPFVGGIGGFASVFVTASFAYGGTESIAITAGETKNPTKTMPRVVKNVFWRILFFYILSVLLIGLDVPYTYPNLSSKKTSTSPFTIVFQMTGARAAGSVINAVILTSVLSAGNHALFAAGRLLYTLAIEGHAPSVLARLGNNQVPWVAVLTSALVAGLCFASSFIGAGQLWTWLQNLVGVSNQLSWIAIGIASIRFRAGLERQGKTHLLPFRNWTYPWGPWAVVILNSFLVLVQGWSCFSPRFDAVGFVSFYVEIPVILIMYVVWKIWRRTKLVGLNEMDLETDVHNVHEVPVEEGKGGGERWRWSSKAKRVLAWLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEZ1</accession>
    <name>A0A367LEZ1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Lysyl-tRNA synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_0261</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEZ1"/>
    <dbReference type="STRING" id="1330021.A0A367LEZ1"/>
    <dbReference type="OrthoDB" id="21243at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070154">
        <property type="term" value="P:mitochondrial lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918:SF5">
        <property type="entry name" value="LYSINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918">
        <property type="entry name" value="LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="7">
        <location>
            <begin position="247"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="22"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="527"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="644"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="555"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI12986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="678" mass="75954" checksum="43739408280CCD51" modified="2018-11-07" version="1">MMYGKCLRLARRTVAGGLGRWTCPSGKTTPSGLYRHAPGRALATGPPDNNDDDDSSGPPEGASRTTKLEDHTSFRQHRLASMDADRLTEEPLYPDDYPRIETQHVTKSVPELLQNFEDCSRRKEPVTVMGRVRSKRVHGSSLIFLDIVNEFQMVQVLLNKKNVTSFKTRRAYKFAFLRSLIQVGDHISVTGTATRSLTGEPTIDASMIPRLLSPSMSQLPDSRKVSKTSDQERHVDMLVNRSTTDILRLRSEITRHMRNHFHSRRFLEMQTPILAEDAGGAIARPFRTRSNAVRSRKDLALRVAPELWLKRLVVGGFDKVFEIGPAFRNEGVDASHNPEFTMCEFYSAYTNLENLIKETEELIHSLAAHCKEVISTELVSLPAIDLSKFKRPFKQVEFVPALEEAMGVRLPKLNSEGAFAEMLVLMELTNIKLSDLMADSLPKLLDQLAAHYLEPMSMAEPIFIINHPSCMSPLAKSFLCPKTYQLVSARAELFVCGRELANMYEEENSPHEQRRKLALHRSLVTKPDGSIAPSEETDRPGNQDDDEKQETYGSEDPRDSRSQKRACDDWVTAPLDRSYIRALDYGLPPTGGWGCGVERLVMLFSGSTRIGDCLSFGTLRHVVGISAPQEGEEEEDFLRVERDGAIESESSETVELEGSSTKEPPGQKMARTRGEEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFA5</accession>
    <name>A0A367LFA5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_0056</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRIAP1/MDM35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFA5"/>
    <dbReference type="STRING" id="1330021.A0A367LFA5"/>
    <dbReference type="OrthoDB" id="19091at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990050">
        <property type="term" value="F:phosphatidic acid transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007918">
        <property type="entry name" value="MDM35_apoptosis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46403">
        <property type="entry name" value="TP53-REGULATED INHIBITOR OF APOPTOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46403:SF1">
        <property type="entry name" value="TP53-REGULATED INHIBITOR OF APOPTOSIS 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05254">
        <property type="entry name" value="UPF0203"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI13114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="119" mass="13537" checksum="5AB255A5A9ECC9C1" modified="2018-11-07" version="1">MSASLAPECNEVKERYDTCFLKWYSESKTARRERASNDLDSPSSEYLRGGEKDSKECDELFQVYRKCLDVIAALNLHCVAQALTLSFQIALKKRGIDKLVDEAREDNKENDARLTAPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFG5</accession>
    <name>A0A367LFG5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Transcription elongation factor S-II</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_1281</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFG5"/>
    <dbReference type="STRING" id="1330021.A0A367LFG5"/>
    <dbReference type="OrthoDB" id="44867at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001139">
        <property type="term" value="F:RNA polymerase II complex recruiting activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031440">
        <property type="term" value="P:regulation of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00183">
        <property type="entry name" value="TFIIS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13749">
        <property type="entry name" value="Zn-ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000001">
        <property type="entry name" value="Probable Transcription elongation factor S-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.30:FF:000003">
        <property type="entry name" value="Transcription elongation factor S-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.30">
        <property type="entry name" value="Transcription elongation factor S-II, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045564">
        <property type="entry name" value="DUF5910"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046533">
        <property type="entry name" value="DUF6598"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003617">
        <property type="entry name" value="TFIIS/CRSP70_N_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003618">
        <property type="entry name" value="TFIIS_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036575">
        <property type="entry name" value="TFIIS_cen_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006289">
        <property type="entry name" value="TFSII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01385">
        <property type="entry name" value="TFSII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477:SF0">
        <property type="entry name" value="IP08861P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477">
        <property type="entry name" value="TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19287">
        <property type="entry name" value="DUF5910"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20241">
        <property type="entry name" value="DUF6598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07500">
        <property type="entry name" value="TFIIS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00510">
        <property type="entry name" value="TFS2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00509">
        <property type="entry name" value="TFS2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46942">
        <property type="entry name" value="Elongation factor TFIIS domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51321">
        <property type="entry name" value="TFIIS_CENTRAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="10">
        <location>
            <begin position="590"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS central" evidence="11">
        <location>
            <begin position="728"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS-type" evidence="9">
        <location>
            <begin position="845"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="213"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="669"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="691"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="708"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI13127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="887" mass="98591" checksum="6A9E0FB3819135F5" modified="2018-11-07" version="1">MHILQAMRIAGFKLIGNTGFSWQREYEEGHELEECDQIQLGRGVYTTPHLNAWKDAGWQCAVFADKEKLKAIPKVVISRQVYQQTLNHDPTMEIHAYIRNLYKDVDPRRCLLIGYIDEGPELQMLIPFDLLDAYQGGLNITVECASSENMNALANKVDIMLDHNVRVNYSSWEGVLGDLSDDEGDYYDYQYDFVGRNTSSEVMAYHSLSSEHQTSLCSGSDDSEVETESPSESQSEDEEPGEYCNLGEHTSRPLEEQFRNAFVQAQTRSVDELQGLYPVIAFPLLALLASGICLPNEHRIRRETPRATIGKNAALQCCQLSQELMGFLVAQNPEIVLDDWEATDRLRALGQVIDVRINNIDGESYGELYGKITVRDPVGEMTLYDVARGSAQESSPGSLVRLSDGKRVIEGSNPFSIDVRLWDRDRISADDLISNGTIEWSLDGPHNQIFSTEVPGTYGSATIRWTVLKFASAANIQVVLINGDGESPANIFGSCQLKTETVARTWFDVKEGGQSDVYKGNVITETSVAVAADTFVEITVNIWDHDVISEPDSVAKGTVAFYPDPGKTARKRVKGDNGEVEVVPFMDQRELEARIKALTKSVAANEPPENAIRLLDMLKKDAAPTEEMLRATRAGVFVGKLRGNPNKEIARAAMELVNKWKKLVEQEKNSKLQKAKMGSPALPAASPPSSAPQNAAASTATRKAFTGDPEKRKYDSDGVDIKRTASNVRNQCIGLVYNGLAFRSTESASDVIAKAVAVEQAVFDSFGSENAEYKKKVRSLFANLKNKSNKELGRRVMTGDITPERFASMTDDDLKSEDQRKKDLELEKENMKKAQVPMAEKSISDSLECGRCKKKRVSYTQAQTRAADEPMTTFCECMNCGHRWKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFI4</accession>
    <name>A0A367LFI4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_0233</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFI4"/>
    <dbReference type="STRING" id="1330021.A0A367LFI4"/>
    <dbReference type="OrthoDB" id="4903907at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI13186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="314" mass="34719" checksum="67EB0F9BCAFB9B39" modified="2018-11-07" version="1">MSRRQRSVKTRVEGNDEVDLDASAFSRAFKTIIRWKYKRKNFKCANGMVSTESSNVESQPRPLGFTSTSQNKGKLTSLVLLETRTGRWKALPRMAINAAKIWLQLNNCSYERETSCYNASFRNYLPQYPSICLSGHHFPIMKPNMFLAALFAIQIEASPTSANELKKGSWYDEDGNTEWLQFQRRGDPSSGATKAVDGPPSGDAYFCSGWKVKAEDAERAIEGLISMCGSGRRFASVMTYATGSAVAYGCSHNYREVTCAQGAYNATGFLRGLRHACGEGNTGFFSLPRTARTARTAVAPFLTFGRPPTIGPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFN1</accession>
    <name>A0A367LFN1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0282</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFN1"/>
    <dbReference type="OrthoDB" id="4863639at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017008522" description="Secreted protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="75" mass="8044" checksum="FC95A8444B539FAE" modified="2018-11-07" version="1">MKPLRLLLPAWATSSAVLVAAFPISPQGPCDPFKVDQILLGKLGHEACCSYGRCKRDVVVSEMPTTEKTKATSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFP3</accession>
    <name>A0A367LFP3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_0340</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Necrosis inducing protein (NPP1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFP3"/>
    <dbReference type="STRING" id="1330021.A0A367LFP3"/>
    <dbReference type="OrthoDB" id="89086at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008701">
        <property type="entry name" value="NPP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33657">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33657:SF8">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05630">
        <property type="entry name" value="NPP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029958">
        <property type="entry name" value="Necrosis-inducing_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016621551" evidence="4">
        <location>
            <begin position="19"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI13246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="240" mass="26707" checksum="A89EF6436A2F6CDD" modified="2018-11-07" version="1">MVAFSQLTLGLTAAACMASATVIKPRLAHDKVEAFPETVPDDLTGKLYKRFKPWLHIIHGCTPYPAVDGQGNTNDGLDKHDGDESNECDHSTGQVYSRSAEKDGMFAIMYAWYFPKDVPSVGLGHRHDWENVVLWFSEKSESAKYLGIAISAHGGYAKYRQGSDKVTWDGDRALIGYTNVWPINHHLDTTKDKPSGDVPLIGWESLPKASWDALQAKNWEEADLSFSDKNFDKLLGDSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFS7</accession>
    <name>A0A367LFS7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">asparagine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_0114</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="2"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFS7"/>
    <dbReference type="STRING" id="1330021.A0A367LFS7"/>
    <dbReference type="OrthoDB" id="43906at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04318">
        <property type="entry name" value="EcAsnRS_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF34">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="8">
        <location>
            <begin position="190"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI13275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="534" mass="59485" checksum="F44786C6F7E6B61D" modified="2018-11-07" version="1">MVTPRVTPRVTPRVTPRVTPPAWRRRQVCRRLASRCYSASAPNSPIRNVADVKAWKPAIDVPHVEVCGWVRSVRKSAGVRFVDITDGSSMRPLQAVVDKALCGDIRPGAAVRLNGILKSTSETTGHVSNIPSSPSVASHKTTHELHVDRVDVLGPSDPRTYPIQNKYQTAESLRTISHLRWRTPLNATLLRLRSDAMAVLTDFFSRQGFQQTHTPVITSSDCEGAGEAFAVRPDDFFKSPKYLTVSSQLHLEALAQALGDVWTLSPTFRAERSNTSRHLSEFYMLEAEMSFVRDMGDVMELVQSMLRALAAGLSQRHAATELHVNRLNSRDPAERLAFADLAPGDELGRRWRGLLGPGTWPRITYTDALARLQPVADQFEHEPQWGCALQSEHERYLAEQLGYNEAEDASMPVFVTHFPQDIKAFYMLPSNSPPAAAGQTTTTVECFDLLVPGLGELAGGSLREHRLKELEDRMRRQGVDKGADMAWYLDLRRWGCPPHGGFGLGFDRLLSYLTGVANVRDVVPFPRHFGRCDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LG37</accession>
    <name>A0A367LG37_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TEA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_0306</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LG37"/>
    <dbReference type="STRING" id="1330021.A0A367LG37"/>
    <dbReference type="OrthoDB" id="10006572at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.40">
        <property type="entry name" value="TEA/ATTS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000818">
        <property type="entry name" value="TEA/ATTS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038096">
        <property type="entry name" value="TEA/ATTS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050937">
        <property type="entry name" value="TEC1_TEAD_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834:SF0">
        <property type="entry name" value="PROTEIN SCALLOPED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834">
        <property type="entry name" value="TRANSCRIPTIONAL ENHANCER FACTOR TEF RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01285">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00426">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51088">
        <property type="entry name" value="TEA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TEA" evidence="8">
        <location>
            <begin position="128"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="TEA" evidence="6">
        <location>
            <begin position="128"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="501"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="713"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="802"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="512"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="713"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="806"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI13379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="875" mass="96943" checksum="3D675029189F44D9" modified="2018-11-07" version="1">MSSSLYQSRPATGTVVSSPSEYADVRRGGSIQVPPGRLPLRESTGNAQSHNFNGIVSCYQSPVALSPSMQANIPAPMVPSQSFDCLYRVPTPRQQPRYHRRPRSAINPLYFWPAFRQYRNRQAHKDTQKDKGGVWRRPELEDAFVDSVLLMPHMGRRKFSMGGKLHGRNMLISEYIFVICVAILGSKEIFRIDNSNESIEQMGRKQVSSHMQVVKKFFEDLRCFHFLFPSEEKKEPGSTNSDDYYDEEEQESFKSNPVLTALAEGRVPDVKPNYEYFSQLLALQSAICVRPKTCEIFVSSSDIKMRDEVAYDAHDAPLDQASFPHLNKYSNCDDSPNVLGKDVLLHEYTRSLDRTTSACVKTTTRRWQKDSPAMYETLELPAQDEECLLLEMCATIELHEHAKFPPGSELTGFVEVAITHPALQHHRWKCVTRLTRPAELGSDEGKTGVYTNDSGIHRRGCSDAKSDCDCHTRPRADIHVPFPAVEWASMLSMAVQYPDVEHQRVREKRRRNADGDKKDLERAGSKRKRSEDEGDAASWSRREPTGSDLICRVAMYQELWSCAPDSTQWTRQAIIFWRFNTTNQWHKYNPVFKPAGTTWRWLTMNDPMSRYHQQKALVYPTAGVSRDAVMSPTPTINQHLTAAMNETFSSAWEGGPVPALQTPANSLSLFESFPSGLATPPPTAGYSTTGSSFDAAMNSGFLSAAGTAAAAAGTTTTAGTTTTTTTATGSGGSGSESGNGRRSYYDGPPPPTAFGDMKPINTAVGPYMSEMPNQLVYDSSPCDTASSMQGWDMATAASLDSWAGSAPTTAGTEWSQASKMEGPGEHPGMWAAAPPHPQQWPLSAGPSSHERGASPRPMKRRRETIDSHVPVTAGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGI2</accession>
    <name>A0A367LGI2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_5599</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGI2"/>
    <dbReference type="STRING" id="1330021.A0A367LGI2"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000050">
        <property type="entry name" value="Aldehyde dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="49"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI13543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="525" mass="55208" checksum="5F293B3E646A258F" modified="2018-11-07" version="1">MIISVYLKHSHDRTGNKKKKMLPPAEAKLKAPNGIEISLPTGLFIDNEFVDSGSGGRITSINPSSGSAICEVVAASEADIDRAVAVARTAFQSPEWRDMPGGQRGRLMLRLADLVEEQTEKLATLEAWDNGKPLAVARDEDLAEVIGCLRYYAGWADKLQGSTIPTSSGGAKLAYTLRQPVGVCAQIIPWNFPLAMAAWKLGPALAAGNTVVLKPAEQTPLSALLLADLIRRAGFPRGVVNIVNGLGRDAGAALASHPGVDKVAFTGSTATGRHVMRAAAAGLKNLTLETGGKSPLLVFADADLDQAARWACSGIMGNMGQVCTATSRLLVDASIVKPFVDAFLHQVRSTRVVGDPFDPKTTHGPQVSRDQYDRVLGFITSATDQGAQLELGGAPAGDADAGKGFFIQPTVFSGVTPEMDLFRDEVFGPVAAITPFGSEEEAVRLANDSEYGLAAAVFTTAVDRAHRVAAALQAGTVWINSSQDSELQVPFGGVKQSGIGRELGEAALAAYTETKAVHVNLGARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGJ7</accession>
    <name>A0A367LGJ7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nucleolar protein 12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_5461</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGJ7"/>
    <dbReference type="STRING" id="1330021.A0A367LGJ7"/>
    <dbReference type="OrthoDB" id="551633at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019186">
        <property type="entry name" value="Nucleolar_protein_12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09805">
        <property type="entry name" value="Nop25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="202"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="150"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI13529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="267" mass="31314" checksum="2583D51C3657CE75" modified="2018-11-07" version="1" fragment="single">AALRLCIVTGLHNAPLPVATRLVHTEVWFPIEPPFGESRQTYHFANLRAMFAKPRPKKSLLPPSNVKRRKLKSSTEEVTFDDDARHEYLTGFHKRKQQRIKHAQEVAAKRAHQDKLDARKQMRIDRRREVEQHVETVNRMLRECGAVTDPVEDDSNQHEEEDEWDGFPDKPNLDILNHEEEFIDEDRYTTVTVETVTISRDGLDKVQNLPSEEEEEGDETEPQRPPIDSEPRKTRLRPTRKKKNFRYESKAERLLGGGAKKRWRRQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGQ7</accession>
    <name>A0A367LGQ7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5493</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGQ7"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="67" mass="7390" checksum="AFBB07D0E9DFF468" modified="2018-11-07" version="1" fragment="single">MLIVSMEQAAFPPPSSTLMTTREALAASSTTPIELRLFKQTMHGGEYVSVEAVCFVALVLIHILRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGU7</accession>
    <name>A0A367LGU7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5537</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGU7"/>
    <dbReference type="OrthoDB" id="3599317at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI13640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="139" mass="15379" checksum="AD2DAB2F1ED0CF94" modified="2018-11-07" version="1" fragment="single">MGIISISFSHLLNTNTSPASNSSLIASFRLSRDSSSSSLSRNHLPDSSTLYPLLATTRNTLLPSFQARATIPIRHCEIREKLQGALGSIAYNKSEDALALIRLQLEDRPLTQIIHLRSAKEAWDKLKDLYNPVSQGYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGW8</accession>
    <name>A0A367LGW8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGW8"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016744775" evidence="1">
        <location>
            <begin position="19"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="73" mass="8158" checksum="2EFB9858AF5C0C6C" modified="2018-11-07" version="1">MLIRRLIVFLKKARLACSLTYPTFLPSYGPYGPYGPAVTYSLCNVRRPRAGYGRPGVTVSSAPAKVVYLDKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGZ9</accession>
    <name>A0A367LGZ9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7952</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGZ9"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI13713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="242" mass="26842" checksum="6E24AC1C5DF17FCC" modified="2018-11-07" version="1" fragment="single">KNKPQARGGTCELFVERVPVRPRTRKRVPGSLQQRNCMHSPPLSSLAVCTVSVTRTPEHFGFETGKSRQQRRPRTTSYRTYFIVNILQEGPPPQRGSSDCLQKASVNFIVTPSASLPCVLHPISAAICISNKVSEPQRLQIIQSRASDTAGRKRGNMQNDKCWRLLEQQGEVDKRKGVLPSPLLQPSARLSSIQFPAEAPSFADHSSHLAPPFISIRQSLPVTNSAYRAHQPLAWPLSCVCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LH93</accession>
    <name>A0A367LH93_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CDC20/Fizzy WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_8143</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LH93"/>
    <dbReference type="STRING" id="1330021.A0A367LH93"/>
    <dbReference type="OrthoDB" id="10263272at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000025">
        <property type="entry name" value="FIZZY-related 2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF1">
        <property type="entry name" value="FIZZY-RELATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="10">
        <location>
            <begin position="292"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="336"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="419"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="549"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="86"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="128"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="177"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="182"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI13781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="607" mass="66496" checksum="C0AC719A9E38DC3C" modified="2018-11-07" version="1">MLPDSQAHAASASSSKRALGEIKTSPVTSAPLSTPASPTDQRRPEAKVNEGSGGPATVRSSSRISDAARAMPLDADAVENALLRELQRPHRESTPIASPHRKRQRINGDRFIPSRSGQDLQASFSLLHEDGSPATPSKQKKRTPHGELHFQRTEEANRTFSTLLRTELFEGSVPQAIHPSLSADNTLPDPSNVNDGTRARTPPNNNSTSSLPSSLTPSTPHKNLFSYLSPRHHSHVAGHPTPSKTPQSRHGPNLDTRAEIYSLSPVRFGSQQLLLSPRRQPRAVSKVPYKVLDAPELADDFYLNLVDWGSANVLGVGLGSSVYMWNAQTTKVNKLCTLEDDTVTSVSWIQKGTHLAVGTGKGLVQIWDAERCRRLRTMTGHTARVGSLAWNTHILTSGSRDRLIYHRDVRAPDQWLRKLVGHKQEVCGLKWNCEDGQLASGGNDNKLMVWDKLSDTPLWKFSDHTAALKAIAWSPHQRGLLASGGGTADRRIIFHDTVKGSVINEIDTGSQVCNIAWSKNSNEIVSTHGYSQNQIVVWKYPSMTQVASLTGHTYRVLYLAMSPDGRVVVTGAGDETLRFWSLFGRRPGTREDGEAGGGRLADWGIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHY6</accession>
    <name>A0A367LHY6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_8190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI14036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHY6"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="285" mass="31260" checksum="5C880948471E9D40" modified="2018-11-07" version="1">MAQQYSLPMRGSMLAKSLLQNALENKIPKGFIIRRQQPTKGTAPVVPIKRLHTAMRLHCKTGLAPPPYQVHVSSPYWVGKGRTNGPIAAEFRRAEVGYSDNQGGKVLERRTLRAEARKKGQKPEFEAPPPSICCQSRRKIRLLFPTALVEKSKRPNNNIHMTAAVAASHSSGHLDRTTMASQQIFSASLGNFNGSGPNDRRPLWEIRMILFGTDSDGRLPMEMEEMGINSRCTRASPGRAATLGGGGEGSAAAAQREVLFLPGLKMSSPVYGEEKTLEQFNEPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LI22</accession>
    <name>A0A367LI22_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_8097</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI14060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LI22"/>
    <dbReference type="STRING" id="1330021.A0A367LI22"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="138" mass="15644" checksum="ADA38F6E87DF90B4" modified="2018-11-07" version="1" fragment="single">TRCKDIRTFSRKKGEFSAFLTNLKDKIRTDKATFRDEEDRIGFLFCSLEGKACKTLETYLLTRTKDDSLSYKDFCGYVKDSAVKRLDTKLVLVSLVPLVDFQGRLASSPNDLPALAKYSLSILLPKTPLLNRQIDLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LI27</accession>
    <name>A0A367LI27_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">GDP-mannose transporter</fullName>
            <shortName evidence="7">GMT</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_8013</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 7">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Golgi apparatus membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Cytoplasmic vesicle membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI14071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LI27"/>
    <dbReference type="STRING" id="1330021.A0A367LI27"/>
    <dbReference type="OrthoDB" id="5547497at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI14071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="322" mass="34630" checksum="13D8C39AFB6BB710" modified="2018-11-07" version="1">MNAPRLPHRDEEMATSDPPSPEPPGRLSVPIAWMAVNTLATVGIVFINKAIFSDASWRDSQLTFACFHFCVTWITLFVLASPGFACFAAPRRPPIRHLLPLALAMCLNVILPNCSLAFSSVTFYQVARVLLTPVVALVNFLLYGATLPLLAGLALVPACLGVGIVSYYDSLPAADVSIKTTSPLGVVFALTGVLASSFYTVWIASYHRKLQMSSMQLLYSQAPIASLMLLYVIPFLDALPDPSGVFASLINISQFFIVAHTGPVSSTVVGHVKTCTIVCIGWIVSGRSAGDRALVGVCLALAAIVVWVIPFLKCHMRRLPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIH6</accession>
    <name>A0A367LIH6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_6038</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIH6"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="69" mass="7755" checksum="E24C7980B24E03FA" modified="2018-11-07" version="1">MAVTATVCRLLQPSGPQRGSQHQEKRYYNEKRAIRRDGRITCCATQAVDIGLLIQIWCANHMSLTGLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIN4</accession>
    <name>A0A367LIN4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_6082</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXA1/ALB3/YidC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIN4"/>
    <dbReference type="STRING" id="1330021.A0A367LIN4"/>
    <dbReference type="OrthoDB" id="2148490at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428:SF65">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX18, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="OXA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI14303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="325" mass="36265" checksum="18687804E31A2E09" modified="2018-11-07" version="1">MLHRTITGFGPTIRARAGAGAGASHATMTGRRHFHLGTVFAWTADAMSSGHAIGLPWYIVIPLVAAGVNFAIRLPIHLYVSRLEQRRRQLRPLVAAWNVRHAINHPNFPEDKRRAVALAKRSRRRIFKEWHVQKWKSSLSMLSAAPFIVVTQALRGLCGAPAFAATGLFDQSLADGGCLWFVDLTAHDSYYALPLLCSGIMAYNIWGKLSRENLRELLTLNENRPKSSAERLKLRLTRVTLFFPLLAAASAYLPSAVFLYWATAFGLGSVNSAISRWRVFEIDPCPHITVPERAPKLRASLPYVLGRCPERKLGEQSRTPENHNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIZ6</accession>
    <name>A0A367LIZ6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aspartate aminotransferase</fullName>
            <ecNumber evidence="8">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_6061</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="8"/>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIZ6"/>
    <dbReference type="STRING" id="1330021.A0A367LIZ6"/>
    <dbReference type="OrthoDB" id="6752799at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006533">
        <property type="term" value="P:L-aspartate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000026">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000001">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF22">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="9">
        <location>
            <begin position="60"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI14347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="430" mass="47734" checksum="5F9544C341C49851" modified="2018-11-07" version="1">MLSTLRIASRRPMTLSACAVRTASTWSAVPAGPPRADFCALPSQAILGITEAFKADLNPQKINLGVGAYRTRHGNHYVLPSVLKAELDIIESRLDKEYAGITGIQGFPVFAARLAYGEDAAVLDRLAITQTISGTGALRVGAAFIQRFYRGNKTVYVPNPTWANHRAVFSDAGLKVEQYRYYDKNTIGLDFDGMLADIKAAPRGSIILLHACAHNPTGIDPTQEQWKKISTEVKNNGHFAFFDMAYQGFATGDIDRDAFAVRHFVEEGHHIALCQSFAKNMGLYGERVGAFSLVCDNVEERKKVDSQLKILIRPMYSNPPIHGARIAEKVMASHNLRQEWLSELKQMADRIIKMRSLLRENLEKLGSVHDWSHITKQIGMFAYTGLSPAHMERLAKEFSVYATKDGRISVAGITEKNVEYLAQAIFKTKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKW2</accession>
    <name>A0A367LKW2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKW2"/>
    <dbReference type="STRING" id="1330021.A0A367LKW2"/>
    <dbReference type="OrthoDB" id="3439480at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="342" mass="39487" checksum="D1874BA9D6198C95" modified="2018-11-07" version="1">MCTTNSWTYVYPDGRRRDSNQRVTLCAASRHGQPCANNRLLKHPEIIMPMAAYPAAPIPLQQPPPLPPYHWLPPTPPIDDSDRVRRRSTSDNRRSGGGGGGGGGGTAHRQPSGRRLSSRDRVVLVENPPSARTPPQTYSTPHTAPSSPRFTSSSRPVIVDERQQLPDDDSSSPSRHRYRQHRRDSSASSRDSSMRPSSRDSHHHHHHHHHRHHRHHHRRLSSNGSNYILETETEARQRRQLRTRQRIIEANAEIAGRPPVPLAPTPRRRSSTYDDARETELVETLRRLDLEERRLVQRVEEDERLRMGRLRERMELPRRRSTVGPGARRHRVVYDDGIYRWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKX2</accession>
    <name>A0A367LKX2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peroxidase</fullName>
            <ecNumber evidence="12">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L249_6659</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 12">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="9 12">Binds 2 calcium ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="9">Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the peroxidase family. Ligninase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="12"/>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKX2"/>
    <dbReference type="STRING" id="1330021.A0A367LKX2"/>
    <dbReference type="OrthoDB" id="2113341at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001621">
        <property type="entry name" value="Ligninase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF66">
        <property type="entry name" value="CATALASE-PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00462">
        <property type="entry name" value="LIGNINASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 12" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="14">
        <location>
            <begin position="138"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="203"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="214"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="90"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="111"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCI15086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="371" mass="39873" checksum="4283C76C04460172" modified="2018-11-07" version="1">MKNSASLIAALAGISSAFPAMEEVVKLAGKRQAPSTELLGDLTTLQDSQLTQTGKDIKSILRGTGSGIDAISTAGNVPPKESTECAQDPCCIWKYIADDMHSAMIDSNQQCNDLAHGSIRLGFHDAWGWSKTTGPAGGADGSIVLAGECESRPDNSNLKDTCNQMRTWFSQYQQFGIQMADLIQMGANVATVSCPLGPRVRSFVGRNDSSQASPRDDLPRGNDTADTHINSFAERTFTPENLVALVGAHGTGRQRTIAARANDAFDSTPGVWDTAFYGEVLDPNAPSQVFKLPSDVSISQDTRTKQTWNTFVGPQGQQPWDAAYATAYVRMSVLGVQNINGLTECTKVLPPFIQSPPAGKRNKTGNLRRMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LL65</accession>
    <name>A0A367LL65_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Telomere length regulation protein conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_6368</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TEL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LL65"/>
    <dbReference type="STRING" id="1330021.A0A367LL65"/>
    <dbReference type="OrthoDB" id="10258062at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.720:FF:000004">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.720">
        <property type="entry name" value="Telomere length regulation protein 2, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038528">
        <property type="entry name" value="TEL2_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051970">
        <property type="entry name" value="TEL2_Regulation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019337">
        <property type="entry name" value="Telomere_length_regulation_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15830">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15830:SF10">
        <property type="entry name" value="TELOMERE LENGTH REGULATION PROTEIN TEL2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10193">
        <property type="entry name" value="Telomere_reg-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Telomere length regulation protein conserved" evidence="3">
        <location>
            <begin position="588"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="506"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="508"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="549"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI15127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="973" mass="105716" checksum="16FA10475F2D3484" modified="2018-11-07" version="1">MDLDLTPVSTTYLRTRHGQELSPSETRPAKKVKEAAAVTSTDEALHALKSQPDYEGLITVLRYLDTSEARLRLPTPASASIIHALVSEIVPNYWILLRENSGTDEAKHLELLLTCLRSVTGLNAIITHCKALIQESKLSSNKVRRPDVELNLRLLLDVLASLLAGHGSIRLLWEASVTNHENSTANKAQSQQLAALVANGRILSTAAEASVVVGKETLSNDLVWLSSGVDFSVWIGRNLSSWASTQMSEGEVAFAFDVFQRSMSLGYTGTVVNTMIDELLLSPRGKPSGFTRICFHQPRLVKKIIDILLQHASQRFLNNAALGGSNLDATVAAVAGVIEFVVGDDEMRTSHLVSWCTASSGAGLGDPVGIRRAVVTVLAKNKETISAVLEKSLAQFGDQLYIKHAAVLQQEVHTQVLLLSAGYVARLAPIKLAMLLRSGTYLSAISNRIAATQARARFLGMVVGEILSALAEGKAKKLDFHMEEMETDEADWLKGLTKTEDHAGSFDSLVSSQDSAPPTSRSVPTVPKPQHKVRPKPGPVAPLPKAIIEEIDSSDDDDDDLVPYAKGSDPEDSDDDATLVQRNKPRAPVYVRDLIAYLRDTENYDKQKLALQSAPDLISRKANYGTEISSHADELAGLLVGLQDKFELQDFVEKRQQGMIALVVAQPKSMAPWFARSFFEGDFSLAQRTSILVTLGLSARELAGQQQEARGGDSFASKRLPEKIERLFLDAAQRPEQQQPASSRLEALPPNALGAITKSLTSSFLEPLAAQAADDTTGPDALKLETFTQRYKSKSNFKARPRVRAIANTTAALLASSFFAPLTAHFQLALGSSKPMVVNPAILSLYLQTLGIVVDAAGPSALALPQMTSELWHLLLRVRPHVLGDVDATRGWLFALTVLIDVNENRMRTLCEELGRELVETRETLAAVFARTRGDDGGEENDVKMLAAGALIKLGEVVEKYQALLIGDLVSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLD1</accession>
    <name>A0A367LLD1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Polyprenal reductase</fullName>
            <ecNumber evidence="5">1.3.1.94</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_6465</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Plays a key role in early steps of protein N-linked glycosylation by being involved in the conversion of polyprenol into dolichol. Acts as a polyprenal reductase that mediates the reduction of polyprenal into dolichal in a NADP-dependent mechanism. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a di-trans,poly-cis-dolichal + NADP(+) = a di-trans,poly-cis-polyprenal + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:80727"/>
            <dbReference type="Rhea" id="RHEA-COMP:19536"/>
            <dbReference type="Rhea" id="RHEA-COMP:19537"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:231623"/>
            <dbReference type="ChEBI" id="CHEBI:231637"/>
            <dbReference type="EC" id="1.3.1.94"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="5">
            <dbReference type="Rhea" id="RHEA:80729"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="5">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the steroid 5-alpha reductase family. Polyprenal reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.94" evidence="5"/>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLD1"/>
    <dbReference type="STRING" id="1330021.A0A367LLD1"/>
    <dbReference type="OrthoDB" id="541710at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003865">
        <property type="term" value="F:3-oxo-5-alpha-steroid 4-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160198">
        <property type="term" value="F:polyprenal reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102389">
        <property type="term" value="F:polyprenol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016095">
        <property type="term" value="P:polyprenol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039698">
        <property type="entry name" value="Dfg10/SRD5A3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14624">
        <property type="entry name" value="DFG10 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14624:SF0">
        <property type="entry name" value="POLYPRENOL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="187"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="6">
        <location>
            <begin position="189"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI15245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="301" mass="33975" checksum="50DADE5E6FBE769C" modified="2018-11-07" version="1">MPAELLAFILSASYPPSLWCQTLLLGTTGVLLALHALPDALLQKLTSYGARNSHHDMTRSSGWVFHQVPHAWFWHFYFVSVCWSAFWAWQYFGRGAVMAALARAQLHHVASTDLGRVYLAWAMMAVQGSRRLFECFFVLRPGSSSMCWVHWLLALVFYTTVGIAIWIHGSGRTILESWASVEPVATLTLRDLSGLIVFLVAWLEQNRCHRYLASLPKYTLPDRGLFRGIVCPHYTCECVIYIALAFVAAPSGRLFNPTLLCVEAFVVANLGVTARGTKQWYAQKFGREKVVGRWNMIPLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLH7</accession>
    <name>A0A367LLH7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLH7"/>
    <dbReference type="OrthoDB" id="10593042at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="210" mass="22962" checksum="F4DAEBB1F31D3310" modified="2018-11-07" version="1">MGHYWPYLLDTVQRRRLSLRLLNRRRTHEQRNRLQWTWRKGKAVDRIVHVNPDGRGGGGGGGGGGGDARADARALPMACPRPNRSPRLLLKTAPKLAQPSPPGKAPIDEADTPKPPLHHHIVRPAFNVKDATPTKRRLVHLPRWTLSVPHRHDAGTHPSAPAEKAAVASSVPETPSQTDAFVPADDHLPAHPADGKVQHGPVARLASQTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LM66</accession>
    <name>A0A367LM66_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TAFII55 protein conserved region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_3455</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LM66"/>
    <dbReference type="STRING" id="1330021.A0A367LM66"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08047">
        <property type="entry name" value="TAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037817">
        <property type="entry name" value="TAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006751">
        <property type="entry name" value="TAFII55_prot_cons_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228:SF0">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID 55 KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04658">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01370">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII55 protein conserved region" evidence="8">
        <location>
            <begin position="177"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="76"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="137"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="344"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="455"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="518"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="352"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="458"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="503"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI15490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="568" mass="62479" checksum="A579BCD7AAD56BC6" modified="2018-11-07" version="1">MTAYDQGGADASPPPTVAPPPAKPRLKLNLNRTSSMVGFSDNAAVETPRKLVKLKVNTQSSPSSQVSTATTATVAAAAAATTTTTKTKAGRQPKPTQKLVESKKRPLEDEYDDELTFANHHHPPPLSAATTTKIKIRQASKSAPTQVVVKPRGRVPHHPPGDGYDSEASDREEDPAIEEQFVLRMLPGEHCDYVRWCMENGKVGVPRSQGGADLTVKFFEEETRRALVTVKGQPFVAVMVDLPTITEAMKTWDKKSLIKSADICQMLLVFSKVKDDTEARSAPLPVIIDSSYRWPHGLTPPMHDCVNRRFAKTISRKEIEDKEAEVERLLAEDAKAVSTKWEWVDDRGGQVEDGDEDAEGEADDSNVGFFPQQQQQQQQGEGVGGGEGGVVIMDVDDDLNKSSNNNDNDDLEADLEAAFADDSIMMASTPATTTMMDMTTPMTAQVETPAAALHESIEKDDESGAEADDDNENNNGDDDDDDDDDDDDDDDDDDEDEDDLDEDQRARRDEEEAVRDIIKDLENQLKARRLDLDKTANKILRSRVENQIKQLESAIELKKSSIGIETDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMV7</accession>
    <name>A0A367LMV7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_3235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMV7"/>
    <dbReference type="STRING" id="1330021.A0A367LMV7"/>
    <dbReference type="OrthoDB" id="4923306at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016892243" evidence="2">
        <location>
            <begin position="19"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI15748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="864" mass="96486" checksum="0DA1BC631F7702CB" modified="2018-11-07" version="1">MHLGRVLVCFVLPWLGTAKSLLHARSPPKPKPIQGSPVGDPRLMYIVGPVPASTAFSIGIHGSYSLEHRVVEWGSYEMVAIVPGRYHVMAHTNPELAIQGWARTWARRRHRRFTSVQIYAVSLTEDDRIFSRSNNDTILYSTYWSPCEARAWPPRFVHFFASLPQITDYALLADRNVVDTIFSRLSWRARRFASLEHLGSLVPVLNAPVGSTVCHCQTNFHLTQQLNEMMSMERQIINSLYTETGELLRDAYCDHLLSRDDYDRCVQMAQDVVRGRFGIQHGGAGVPLEAMNHQSMMAHRPMTLGANPLANVPPLLPAPEANFPLGMVHPSAQIPPPPALPEMNPQVPPPIQRAPNPYARPAFHVEPPVRMDPTAPMMSDPEPIPGPSYQEHPPRPYPPAAEVPLQFPVPNPPPEPPLPAPGLSQRRLENELQEFACQETLTEGDIFQGVWDALRPFVGMNVELLQQHFPNLDAASLHILSQGSCSRFDNHYLHKRSIEEEESSESTANATSCKDLAFSIAGKASGFSPMMEAQLLKPTLDGLEETENCMQLKSLHVRIELSSDVIYGWEGAGTNDDIYIEVGNQTILLLNSPWRGSVADKPVDLVKAFGSQPVSFDKFTTFSLFPRRSETMGPGGDPFKLKGLIFTARCESDPHREVIVDKYSSVNKDIYRLRWPSKYDGRIAVKDWHYSPFDTKAQTLAVSPPGRRDFCSHLKALQVRLTLDGLWQSWFSGGTVDDVYLSIGMENQPGKGTILLAQSPSAGQEFTTDVDLVKFFGRKTVPVAAVLSYVDIYATTGSGQSVNYTDGWQIKSIVFDGQCSDSNNTVRASIDFPDGKWVERQAGKEWGLVYTHDKIGLQRWFRVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LN19</accession>
    <name>A0A367LN19_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell cycle control protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LN19"/>
    <dbReference type="STRING" id="1330021.A0A367LN19"/>
    <dbReference type="OrthoDB" id="2398441at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033768">
        <property type="term" value="C:SUMO-targeted ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038886">
        <property type="entry name" value="E3_SLX5/Rfp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28042">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE COMPLEX SLX5-SLX8 SUBUNIT SLX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28042:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE COMPLEX SLX5-SLX8 SUBUNIT SLX5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="43089" checksum="195758352F4628DF" modified="2018-11-07" version="1">MPPPVGSWLEANSDDEPVEIGITRLQSLQNHDPQRLPTPAGQRPNLRPERQRSPRRPSRSEWPIAVIDLTNEPDSPEDQRSQQRNPRRTNSQHASPPRLARSDRSFISPFASFIDLTGDSPEDQRGPEPPRLLRPRHTFPRHHHHHHHHHHHHRPRQNQHQNQPQRGGHFQSFDDEGFIGLEYISDGPFGLLHDDAARSLHRIPVGLHSGFTVPSAWRRSGFNPPSWEFAAAAAASFDDEIRDRTPKPPMEEVPPARAGFTRDTGEDNDSGSGKMIVCPACKEELAYDKSSTTSAQAIPGSSSRKRRKMLGEHHFWVLKKCGHVYCADCFENRRPTKALPNGAGFRGSGSRAPGSSSSVNDLRCAVADCETKVAHKSEWIGIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LN82</accession>
    <name>A0A367LN82_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Formate dehydrogenase</fullName>
            <shortName evidence="6">FDH</shortName>
            <ecNumber evidence="2 6">1.17.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">NAD-dependent formate dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_2016</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>formate + NAD(+) = CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:15985"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.17.1.9"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.1.9" evidence="2 6"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LN82"/>
    <dbReference type="STRING" id="1330021.A0A367LN82"/>
    <dbReference type="OrthoDB" id="418179at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008863">
        <property type="term" value="F:formate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042183">
        <property type="term" value="P:formate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000057">
        <property type="entry name" value="Formate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03210">
        <property type="entry name" value="Formate_dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033689">
        <property type="entry name" value="FDH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005750">
        <property type="entry name" value="PRK07574.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42938:SF9">
        <property type="entry name" value="FORMATE DEHYDROGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="3 6 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="8">
        <location>
            <begin position="8"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="9">
        <location>
            <begin position="104"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="149"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="204"/>
            <end position="208"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="285"/>
            <end position="288"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="6">
        <location>
            <position position="232"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="6">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00071864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI15860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="336" mass="36915" checksum="CD9C02C15D8497DC" modified="2018-11-07" version="1">MELNLRKWLQDQGHTLVTTSDKEGPDSKFEKELVDAEIIITTPFHPAYLTADRLAKAKKLKLAVTAGIGSDHVDLDAANKTNGGVTVAEVTGSNVVSVAEHVVMTILVLVRNFVPAHEQIVKREWDVAAVAKAEYDLEGKTVGTVGVGRIGERVLRRLKPFDCQLAYFDYQPLDEAVEKELGAKRYLRLEDMLEACDVVTINCPLHEATRGLFDKKLLSHMRRGSYLVNTARGAIVVKEDVADALASGQLAGYGGDVWFPQPAPADHPLREARNRFGGGNAMVPHMSGTSLDAQARYAAGTRAILESYLTGKFDYRPQDLIVHNGDYATRAYGQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LN94</accession>
    <name>A0A367LN94_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_2541</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LN94"/>
    <dbReference type="STRING" id="1330021.A0A367LN94"/>
    <dbReference type="OrthoDB" id="5345494at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI15857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="504" mass="55193" checksum="B95D032429D039DF" modified="2018-11-07" version="1">MSRAIVIGQPLPKPKTTSLPSLYDTLHNSLILATVAPYLPLSSILNLAATDKAFRALVYSTPGVFRHLDLSCLRQARLELSDSDDSDDTTDFWHSPRLDGSVTEDDFYSGPLRGIISNLRRRDILSVVQTLVLDGLSVTAELCRDIINDASLNVRILSLREVTNLDHVTLRAVLRYACRKTRPDNTPKLRALYIFGDKEWSPPPPRSGYAAPTGSDWNHKSRRALSSSLRRDGDAWWARRGRMITGGTAHDWGDCMLACDGIIAFDSVVCQGPRHRNSPARPSPPIELHPPAAATFAVSACAGCGSAPEGLVHPTRLPARLPLLAPLPISSSSVVAATTPHHPYQPFVGRCGECIGDRYCLACHRWWCENCYKSPGQAVVIDDDATTPEGFVAAVKIEVRNLRCHQCDYDYERTDPLFVTFIGIALDAPCGCALTLSNPSSLHMAAQNRISKSCWECGNNCDACIDQTQRVCRKCCGGYCIIHNEGSSSSHVRCVSRGRGLGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNF4</accession>
    <name>A0A367LNF4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_2831</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNF4"/>
    <dbReference type="STRING" id="1330021.A0A367LNF4"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF7">
        <property type="entry name" value="CIPA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="19"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI15917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="349" mass="38234" checksum="002188ED9525FE68" modified="2018-11-07" version="1">MAAKYAKDQPAGFTNRIERVAIVGATGKVGSYMTAALLSTGKHVVTAITRKGGGSNSNMPKGVKVAEVDYDGEETLVDALSGQQFLIVALSATAPSDTQEKLARAAAKAGVSWMMPNCYGTDVRNAALEAENLSGPPILGGIDAVERAGVSWVAMCCSFWYEYSLAMGPCWFGFDFNKKEVTLFDQGTTRINISTWDQCGRAIAALLSLKELPQDESDESVTLSRWRNQPLYVSSFLISQRDMLDSIHRVQGTTDADWHIEHEECGARYKRGMELLQKGDFRGFGICLYTRTFYPNGDGNFEAKYGIANHPLGLPKEDLDDGTERTLKMLAEFQRSPAYLHAYGSGETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNL0</accession>
    <name>A0A367LNL0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_1978</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNL0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI16024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="84" mass="9536" checksum="9B70D0E27B8A2BB1" modified="2018-11-07" version="1" fragment="single">MSPSWTQRSTAYSATNERPLRSIQGGFLHISYPDTIRRRRRQNTGLLTWLGELDRWTSNRSSESGIEITDRQANGTLARAITVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPP5</accession>
    <name>A0A367LPP5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="2">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_2241</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPP5"/>
    <dbReference type="STRING" id="1330021.A0A367LPP5"/>
    <dbReference type="OrthoDB" id="10264196at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06822">
        <property type="entry name" value="PLPDE_III_YBL036c_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000007">
        <property type="entry name" value="Pyridoxal phosphate homeostasis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00044">
        <property type="entry name" value="YggS family pyridoxal phosphate-dependent enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PROLINE SYNTHETASE CO-TRANSCRIBED BACTERIAL HOMOLOG PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146:SF14">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE HOMEOSTASIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004848">
        <property type="entry name" value="YBL036c_PLPDEIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine racemase N-terminal" evidence="5">
        <location>
            <begin position="27"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2 3">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR004848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI16415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="260" mass="27787" checksum="C14B87EA1202CB29" modified="2018-11-07" version="1">MTEEMRLDPSKTEALVSRLTCIRDRVTAQAQGRNVRIVAVSKLKPANDILALHREPASHNHFGENYAQELSQKANLLPRSIQWHFIGGLQSGHCKSLAKIPNLFCVSSVDSAKKAHLLNTARAALLSSNPSLPKLSVHVQVNTSAEEAKSGCPPGAETVALCRDIVDSCPNLRLLGLMTIGAIARSKAAAEGDPNEDFVSLAKQRDLVAAELGLSPDSLELSMGMSDDFENAVALGSGEVRIGSTIFGTRPAKSDAKIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPX6</accession>
    <name>A0A367LPX6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_1859</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPX6"/>
    <dbReference type="OrthoDB" id="5538558at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
        <property type="entry name" value="4HBT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI16292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="26165" checksum="C019B758419894F3" modified="2018-11-07" version="1" fragment="single">TNEANQGNTACYKSARLAESSYLSPYSRLGAPDRAHPNTDPYAPLRTRALATLEAMGFDPNLMVEHGVLWADHQDPYGHVMHSQYMNFLGATFWRTLESYDEFLTHEECDNMVQAKTVIPALKKYELDIKRQVKYPDSLIAAYRQDGMDPSRSHGTSVLFSLKQQAIVAEVKGFVTYVDVKTARPADIRSLGPNFVALYQGISRRAERARALREQWEKDNPKRRGGAPTANI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQ02</accession>
    <name>A0A367LQ02_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_2477</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQ02"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI16450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="103" mass="11924" checksum="C73C07061A0F87E9" modified="2018-11-07" version="1" fragment="single">LYAPSTQISVILNYSELCYTAIRPQLATNLRIPIERISPYRIRAYTLLFYSLRIPPLARRLLGLGLISRLPFYPSLGDLLRPAYNGFRLYRLSYPQPSHNDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQ09</accession>
    <name>A0A367LQ09_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQ09"/>
    <dbReference type="STRING" id="1330021.A0A367LQ09"/>
    <dbReference type="OrthoDB" id="5335210at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="647"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="968"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="703"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="755"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="874"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="968"/>
            <end position="981"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1044" mass="112046" checksum="A1E75830C58394B9" modified="2018-11-07" version="1">MNRLRGKKKNKDDAFPARPSIDTESSGPFRMFAKKKSQEEEEPKKVVDLTAALPPSDDFRTSLLMTGLSARFSMLREQDDPHSKLGKASDDSVLFPKRHSRLGDYGLAAALPDITEIESIKAPPFARVDSYVSSDDAASTNGSIMNRGKPSDGNNLFGGRQKIYKIPVGSTAKGGGMGGRALYDDDVAQSAFQRWRQAERERHSLERDRKDEPADAADPDYSRRRETSSTTSSAAARNSTAATSVASSQPASVKDWPVNQSSTTLERSVTRTRRLYEQGLSQDLHEQQSSALSRMDTLSRARQLGSRTPEPAPLVPSPTGMAFGERPQERRPIISKASAPNLRSFSPPTASSSTYTMSPPESTSKFSNKLDPKPNYGGNPPLSPPISESEDYPVLPIQPNDRGKATAMGVFQRPVQQYDESKYAQRQRQLQQGREMPSSDSNLVLGGTFRSASSSSSRRSEKTMASMEVAARKETHSTTFFDDSDDASVDNRSSIPSIPPHLTIDRPDDQDHPALRGAALPTPMSLSSLALSDETDSLADKPGELSPDQPLDSPTLGPNSGLSGLVRQHLRHDSVASSISGITDRDSMALPSSGGKPNRRREQADKVSPVSDGPRIREDGLAGNQDDFARHLADGARRVRERLTTYVETDAPSTPLNAANKDEGALRPNGLGILRSKSSRGSLRDRHDQEPGQSRLFKAQMPSSMSAGSSVSTHTSFASARDDGPGSSERLAGKESPSMNKDDSAPAGLKAFRQARRELQKMKELETRQRYQKSTGEMGHAEEGGTTHPAFLNRRPRDESANSNRSSECSRAASDSRERSGSEASTVMTSYMRGARQRNGSVTYDEYQGPYGGLGRSSPNNGLTGLAGWDIRPSTGTSMSPSQSTGAIDGTGRRSGPRGSSKAGSPNPQRHKMLHEGQPYRSAGLPSAAASTPNLHAAVAAAPPLPPINPRRKNGFGATMVRPAMEHASASHGSLSGGSEAYATAPTSEDEGFPKYRLGGRRATAGDGGRAKATSPPKLSARTMVSQVNMTRGGLPGGDCLSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQ24</accession>
    <name>A0A367LQ24_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">U3 small nucleolar RNA-associated protein 13 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">L249_2087</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the ASTRA complex involved in chromatin remodeling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LQ24"/>
    <dbReference type="OrthoDB" id="5414888at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02669">
        <property type="entry name" value="Peptidase_C19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001009">
        <property type="entry name" value="Small nucleolar ribonucleoprotein complex subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000068">
        <property type="entry name" value="U4/U6.U5 tri-snRNP-associated protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033809">
        <property type="entry name" value="USP39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013934">
        <property type="entry name" value="Utp13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF15">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08625">
        <property type="entry name" value="Utp13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="3 13" id="KW-0853">WD repeat</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="129"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="247"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="295"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="445"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="559"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="634"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="657"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="708"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="domain" description="UBP-type" evidence="17">
        <location>
            <begin position="1069"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="16">
        <location>
            <begin position="1191"/>
            <end position="1505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="194"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1004"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="213"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RCI16470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1516" mass="167672" checksum="C47C2B9054EDD12F" modified="2018-11-07" version="1" fragment="single">MPMMGVRLNEGGSPTLGFQFYIDPSQSPSAMTTKQPLKTTFEANRVLKPTYTGGSVAIDNDARILVTTLGEKAVLTNPANGRHLAEVEGVVSPSASHLIICSRSLSMRIFALKYSSDGNSVELTLLRTLKPLTTPVAVLAVDRTGTLLATGGTDGTIKVWDIARGYLTHTFRGPSVLVSALHFFEVAAHTQITGRPSKRRKGDKVREEPGAEGTQQGTTTSFRLASGSQDGKVRVWDLHKRSCVANLDSHVSDVQGLDYSPEQRAIVSASRDKTIVWWDATSWKVRKVVPCLELIEAAGFIDDGHLTFSAGSNGHLRVWDTDTGRELSQKQPAKSDEEAIVSTIHRPGLPFILCTQVDHTLALYHLPTMANGTPLSPQEPFRRISGTHDEVIDLSYVLPDKSMLALATNSEDVRLISVLETKAAARPERWAQDKAPYFGQEVALLRGHEDIVITMDVDWSGHWIATGAKDNTARLWRVDDSDGSYVCWTIFSGHAESIGAVALPRAVPAEGTLSRTDPLNHPPPFLLTGSQDQTIKKWEIPRQPQPQDQKPCSRAVFTRKAHDKDINAINVHHAGLLFASASQDKSVKIWSVKEGEVQGILRGHRRGVWTVQFAPAKLAAIQTEDSSVVGKGVVLTGSGDKSIKLWNLADYTCIRTFEGHSHSVLKVAWLSGSTGPSQSKRPMLFASAGGDGLVKVWDANSGETECTLDNHEDRVWALAVDAETDAIISGGGDGKITFWKDTTAETQAAATQAALKVMEQEQELQNYIFAGSYREAITLALQLNHPGRLLNLFTSVVTSGKPEEGSLCGQKAVDEVLANLSDEQLFLLLLRLRDWNTNARTAPVAQRILWTLVRSYPASKLSNLSVRGGKGQKSLEDVVHALRAYTERHYKRTEELVDESFLVEYTLQEMDNLAPLVDREDVVLREGGDGDTLCSELCSSITARLNIRPEADVFATNQLARHSSGKVVVVRALSVLAAVGGGESRFAMSKRHASDVLEDEASAALPASKKSRTDELDGVLNGTGESGDGVDDKDKGNGGGDVLGDEDDEMEDRMPLPGPIRQDAPTEGYDDLYLDTIDRNVLDFDFEKLCSISLSNINVYACLVCGKYFQGRGPNSHAYFHSLDEDHHVYINLETQRVYVLPEGYEVKSKSLDDIKYVLDPRYSKREVLTLDTSTAYSWTLAGKQYRPGFVGINNIKENDYFNVVVQALAHVKPLRNRLLLDGLDKRPELVKRCGILLRKMWNPRAFKAHVSPHELLQEVALRSSKRFTLTTQSDPVDFLAWFLNHLHLGLGGSRTRPGSSVIQRTFQGRIKVESQAITARADAGDKLRFEEAGNVNVDTVRFLLLTLDLPSAPLFQDELEKTSSPRAQEQHAQRKRYRLLHPLPPYLIFHVKRFSQNKFVSERNPTIVTFDARNLDLSPYVEPDPGQWPPSEPIWYDLVANVVHEAVRTKDDVADTGDERKTWKVQLRDKATGQWLICQDLFVEKIQGELLYLGESYLQIWERRTVSEASNSTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQG2</accession>
    <name>A0A367LQG2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_3331</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQG2"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI16627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="139" mass="15387" checksum="1B813CCC27DEB494" modified="2018-11-07" version="1" fragment="single">CSCVLLSCQLRESPPISSPATKVVTCRVRLSVTVTNHRHQSSFSSVLITPYYPMKKKKAMPRIAINVKLREPSWHHRQSGSPYIQPTRLIRLPSRSIALALLPGSSSTQPSLIPPGRRPSFRPTLTLSPVGKVLLLRGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQI2</accession>
    <name>A0A367LQI2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein PBN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_2213</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQI2"/>
    <dbReference type="OrthoDB" id="3360032at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031501">
        <property type="term" value="C:mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019433">
        <property type="entry name" value="GPI_ManTrfase_II_coact_Pga1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28022">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2 SUBUNIT PGA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28022:SF1">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2 SUBUNIT PGA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017033309" description="Protein PBN1" evidence="2">
        <location>
            <begin position="24"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI16669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="239" mass="26427" checksum="8F3DA8731A181873" modified="2018-11-07" version="1">MGRRSRRRPPLLLAITSITSVLANVEKVIFTGPPTVNIPPVKPSLADLGLDFLSPHHTAIRTNLSRIFPADEGLASRGQSTWLLLHHLVEGRQYELRVCWAAVEPTSFTLDVHQLDHAWDTPDLIQSLFDYASSRREVDVPADAGDNTSPQSQESVLLLHVRAAADYFTDDVQLMRHAPPVLVDLILDPFLYNLVPLSLVPTAGFLVLVAVVTWFVAQWVSSGLGSVAQHPEKHAKKQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQU0</accession>
    <name>A0A367LQU0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Malate synthase</fullName>
            <ecNumber evidence="3 10">2.3.3.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_2951</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>glyoxylate + acetyl-CoA + H2O = (S)-malate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18181"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the malate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.9" evidence="3 10"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQU0"/>
    <dbReference type="STRING" id="1330021.A0A367LQU0"/>
    <dbReference type="OrthoDB" id="186072at2759"/>
    <dbReference type="UniPathway" id="UPA00703">
        <property type="reaction ID" value="UER00720"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004474">
        <property type="term" value="F:malate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00727">
        <property type="entry name" value="malate_synt_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1220.12:FF:000001">
        <property type="entry name" value="Malate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.360:FF:000001">
        <property type="entry name" value="Malate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.360">
        <property type="entry name" value="Malate synthase, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1220.12">
        <property type="entry name" value="Malate synthase, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044856">
        <property type="entry name" value="Malate_synth_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011076">
        <property type="entry name" value="Malate_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006252">
        <property type="entry name" value="Malate_synthA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019830">
        <property type="entry name" value="Malate_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001465">
        <property type="entry name" value="Malate_synthase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048355">
        <property type="entry name" value="MS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048356">
        <property type="entry name" value="MS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046363">
        <property type="entry name" value="MS_N_TIM-barrel_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902">
        <property type="entry name" value="MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902:SF1">
        <property type="entry name" value="MALATE SYNTHASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20659">
        <property type="entry name" value="MS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20656">
        <property type="entry name" value="MS_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01274">
        <property type="entry name" value="MS_TIM-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001363">
        <property type="entry name" value="Malate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51645">
        <property type="entry name" value="Malate synthase G"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00510">
        <property type="entry name" value="MALATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Malate synthase N-terminal" evidence="12">
        <location>
            <begin position="10"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="Malate synthase N-terminal" evidence="12">
        <location>
            <begin position="90"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Malate synthase TIM barrel" evidence="11">
        <location>
            <begin position="182"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Malate synthase C-terminal" evidence="13">
        <location>
            <begin position="434"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001363-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI16592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="560" mass="63201" checksum="C370E5BA805FF14C" modified="2018-11-07" version="1">MSSTESILQGVSVQGKVDDIHRKILTPQALAFLALLHRSFDGTRRALLERRRLRQSELDRGVLPDFLPETRHIRENATWRGAVPAPGLVDRRGKVDDIHRKILTPQALAFLALLHRSFDGTRRALLERRRLRQSELDRGVLPDFLPETRHIRENATWRGAVPAPGLVDRREYRLRTDRTLPTLIVRPRGWHLDEKHVTVDGQPMSGGLFDFGLYFFHNAAETQRRGFGPYFYLPKMESHLEARLWNDVFNLAQDYVGIGRGTIRATVLIETILAAFEMDEIIYELRDHSSGLNCGRWDYIFSTIKKFRNNSSFVLPDRSCVTMTVPFMDAYVKLLIQTCHKRGVHAMGGMAAQIPIKDDPQANDKAMENVRADKLREVRAGHDGTWVAHPALAAIAVDIFNAYMPTPNQLFVRRDDVTVGRNDLLNMNVPGSVSEDGIKKNLNIGLGYMEAWTRGVGCVPINYLMEDAATAEVSRSQLWQWVKHGVSTSDGRKVDKAYALKLLDECADGLAAKAPKGNKYKLAAQYFAGQITGEDYADFLTTLLYDEITQLGSPRPASKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRF0</accession>
    <name>A0A367LRF0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_2304</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRF0"/>
    <dbReference type="STRING" id="1330021.A0A367LRF0"/>
    <dbReference type="OrthoDB" id="2108at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050596">
        <property type="entry name" value="AspAT/PAT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46383:SF1">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="108"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI16991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="463" mass="52263" checksum="32DBDA12B52FA4A0" modified="2018-11-07" version="1">MYEYRGRKFSINRHTGVPKPMMRRFSNVEPSMNEIQSKVHRQFRNAHEGHMPHAGLDASRSSTGVVWCTERASEYGYLEEPDAWANLGQGAPEVEDDIDGCFKRPESIDVSMAAREYAPTAGIKPLREAVAKLYNEMHRKGKESLYTWENVAIVPGGRAGLIRIAAVLGNAYLSFFLPDYTAYNEMLSLFKNFAAIPVPLSEEDGYHIHPNKIAEEIARGTSVILTSNPRNPTGRVVANPELAEIQDICRGRATFISDEFYSGYNYTTDCDGSTISAASNVDDVDEDDVLIVDGLTKRFRLPGWRIAWVIGPKEYISAIGSCGSYLDGGACHAFQNAAIPMLEPKLVHTEMVHLQRHFRDKRDFVVKRLREMGFVIKYVPDSTFYLWLNLEGLPESISDGLNFFQACLEEKVIVVPGIFFDLNPSRRRDLFDSPCHHFVRFSYGPRMDTLRMGLDGIERVVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRQ9</accession>
    <name>A0A367LRQ9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRQ9"/>
    <dbReference type="STRING" id="1330021.A0A367LRQ9"/>
    <dbReference type="OrthoDB" id="5383784at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI17133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="535" mass="59968" checksum="FC21328025C911D4" modified="2018-11-07" version="1">MGMHGPLAAQALGRSPYDDVVRGEGEENVRQPTQQYNNRGHPINPETRRLNRQIVRSHNEVMLVIGVAETDNPTSTAEPDYQARHEAYENSVGAVLNTPAKSSIDAVGLLGFIGLRHRILTYTRYSRIPFWDLFRAARRNSTLSRDIFAGTPTAIVTQYAQSLANHRRLKARDKAVVRRCIHWAWLYIRSHLEYFVVLQRLGLAPNSLFLPKPQFFIPFTQLSPIKASSLPEDLSFPSLLRWIGGALISTAPFMIWAMTRYILHRFHRPIWSLFRLPNTSRFARRSPISSQGLPPIPAPSDPSQSTATPELSRGSSDGMPRPEAPPETDNSRDNGTSPLQDAESHTPDQSNSPAAGRRPSTFSSRADDYASDEDENEGVSTTLISFDVEATDTSDAPPGLWSAELRPSMASDSRTSVVLPILYLDTRLTQIPVWMAYRIFGTSLDRLMVAPFEAIAFRLAARQSRLQQGLSCADIFTTDLTSGLSLTWAVNFFATELLHMALCGEVWAVFTAITQWFHKTDEEWKQKEEEARAQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRW7</accession>
    <name>A0A367LRW7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRW7"/>
    <dbReference type="OrthoDB" id="201504at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251:SF17">
        <property type="entry name" value="STEROID 5-ALPHA REDUCTASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI17159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="309" mass="33955" checksum="610BB9392E7B855A" modified="2018-11-07" version="1">MSLLQGLLRTTAFRSPLLQTAVPCIATAFAIQALFAVPSTMCRSERFYDLSGSVTVFAVGGLGLFLPAMRMPSWSWSSLLASRHWRQVALTAMAMVWTLRLGSYLFNRVLSHGTDSRFDKIRNRPFVFASAFAAQATWVSAIMMPVLLVNAVPSAAALPASLGLFDLFGFSLWAAGLALEATADRQKGSWLEGRRLKQHDEPFMSDGLFSFCRFPNYLGEISLWTGLATVAASTLARRPVQLALGLGGGPAGIMTTTALAMLSPAMTTFLLTRVSGIPLSEAKYDKRYGDREDYRRWRQNTPRLLPGLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LS38</accession>
    <name>A0A367LS38_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mitochondrial fission process protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Mitochondrial 18 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_2859</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MTFP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LS38"/>
    <dbReference type="OrthoDB" id="424969at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019560">
        <property type="entry name" value="Mitochondrial_18_kDa_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11001:SF2">
        <property type="entry name" value="MITOCHONDRIAL FISSION PROCESS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10558">
        <property type="entry name" value="MTP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="275"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI17264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="285" mass="31798" checksum="4A12D1BE1DD14D24" modified="2018-11-07" version="1">MPWWGKSKDSNQPEKAQEKDASSQNSTFDPDKLPAREKLPKGLQKIVNEADADSRFFDDIRDGYAPPSTDSNVRYAAYATRFRTIISAAHRYVAYTSDIGESFRPVAHWKVVRAAYGISWLYIGGDVSYEGYKAYWQNQRIRDPQLQLTARQEQMTGLPAQGAPDAIPGVVAPLDDWRTVMVQRGVFQSIASMGLPAFTIHSVVRYSGTAMKGVKNARIRTWAPIGLGLAVVPFLPQLFDEPVEKAVEWTFHKAFETLGGKQYVGSSPATGREALLNERPKAKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LSN7</accession>
    <name>A0A367LSN7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_2793</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LSN7"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="15"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI17431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="109" mass="11867" checksum="1E557C9ABD3E482D" modified="2018-11-07" version="1">MLRRISKPAGMSSTIVIVIIIISISIIIVIIIVIVIVIVIVIVIVIVIVIVITTKKNNASTVCPACSSWPFFFVSPIEATLFLHLGQEKQSKEGEGKNQSNEAVELLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LSP1</accession>
    <name>A0A367LSP1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_2402</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="2"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LSP1"/>
    <dbReference type="STRING" id="1330021.A0A367LSP1"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF9">
        <property type="entry name" value="HECT-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="7">
        <location>
            <begin position="809"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="33"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="206"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="270"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="338"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="152"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="290"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="1124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI17370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1156" mass="129235" checksum="B4093D759E10FFD4" modified="2018-11-07" version="1">MASSTRNRHDLVTRIHDSALLTPTALPARLDIANPETSTESESDFEHRFASRHSRSMSNPFPSLFNSKKKRQDSTPLPSPSCLELECEGGGGGPAMPAQSPRKHKRAGPFGSKDFATGNCMTCASLVKWPKELNVFKCTICATVNDLVPAQKKESHWSRPSSRRRDETTTSSSGAQPISFQLTKRLVKQCLCSFILRRLCIKPISSSEDPSPLPPRTPCNGQQRPSPNGRGYVKSGADRDALTAHEPKFVFDEEPTLHPNNIALRSFSASFPDHHSAHPPPPTAVPPGSRRREPSTARKDEARRVFKPLTDYIASCFASFASVNSSFMTSSRQTGRIGGEFAIRRKPVPARESQKRQQPPEPAKESPIMDYFLSDLDPKMLLLGDFAENGTWWAGGQQGATASPASRADGPSKASASSKSPYVNWHELSEWYSMVINAAEGWHDVLDELSRDAGVVRPADEHLRALERDLLDAQFHVQRLLLKVTEMLLKRPGRPLTNPVDLRFLLIILENPLLRADAQTFEGFLQTAASPRRGSLAGQSVASRRGLSSGHHSGIIKRIVGLLSNSSTECHNHLIGWLARYHTARFVRVKDLFSGFLTYRLLREGDKARPPQVDITAGLIPEMQTGRSVAAYLHDEIASGASKKQKELDKKTAYTDDWQIKAAARVLALLFAASNLPKARQGDDSSTHAGEAQIATVRDSVHANGQLLPTSDFYNLVIDNIDLVADFESWELKRSKFCFCQYPFLLSIWAKTKILEYDARRQMQNKARDAFFDSIMTRRNIKQYLALDVRRDCLVDDSLKAVSEVIGSGSGDVKKALRITFRGEEGIDGGGLRKEWFLLLVREVFNPDHGLFLYDEDSRYCYFNPNSFETSDQFFLVGVVMGLAIYNSTILDVALPPFTFRKLLAAAPAHGQGPSSHPRPSMKYTLDDLAEYKPRVARSLRQLLEYDGDVEETFSLDFVYEMERYGTSVPVPLCHGGERKPVTKGNRREYIELYVRHVLDTAVARQFEPFKRGFYTVCGGNAFSLFRPEEIELLVRGSDEPVDISALRAVAEYDNWGRGKPDGEEPVVGWFWETFARAAAADQRRMLLFITGSDRLPAMGAAMLTIKISCLGEDCGRYPIARTCFNMLSLWRYQSRQRLEAMLWRAVHESEGFGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LSS1</accession>
    <name>A0A367LSS1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_2248</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LSS1"/>
    <dbReference type="STRING" id="1330021.A0A367LSS1"/>
    <dbReference type="OrthoDB" id="58297at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47562">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47562:SF2">
        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="2">
        <location>
            <begin position="31"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI17437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="280" mass="30297" checksum="302C8094E1C3157D" modified="2018-11-07" version="1">MLIKEDSVDVPTPAGNMRIFLFHPVIPGYSKARFPGVCLFSEIYQVTGPVARFGRQIAGHGYLVAAPSSFHDFASPEPFSYDAADTDRGNKFKVEKTLASYDADAKATIDHLLSLPNCTGLIGATGMCLGGHLAVRAALDARISACVSYFATDIHSRTLGPHAQPNPNPSSSSSSSSHTLDRLSDINAEVALIFGVKDTHVPDAGRDLIRAKLREADVVFSFYEVAGAQHAFIRDELSKGRYDPAVTKVCFEILLELFGRVLKTDLGERDFAVSPPEHVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L111</accession>
    <name>A0A367L111_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein YTM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">YTM1</name>
        <name evidence="9" type="ORF">L249_6257</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat WDR12/YTM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L111"/>
    <dbReference type="STRING" id="1330021.A0A367L111"/>
    <dbReference type="OrthoDB" id="10251381at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03029">
        <property type="entry name" value="WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028599">
        <property type="entry name" value="WDR12/Ytm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855:SF11">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855">
        <property type="entry name" value="WD40 REPEAT PROTEIN 12, 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="8">
        <location>
            <begin position="8"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="160"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="210"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="370"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI08101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="476" mass="50790" checksum="106444FB05EB14EB" modified="2018-11-07" version="1">MDSSSVQIKVIFTTNEPDLQLPEPKQQLLVPADIKRYGLSRILNSESMLDTSLPIPLDFLINGTFLRSSIQDYLAANGLSSETTLTLQYVRSLLPPAYQATFQHDEWVSDVDVLSSTASAGKVAQDGPVNDRVATASYDGLVRIWNASGNTVAVSPAGRAGGHTRRINAVRWLSPSKLASAGLDEKIVVWDYTEADDGSSSGSLKLNMELWGHRKQVIAISANASKKRILTASSDGHVGFWTTSKSAAPQADPESLPSAFISKRAKLSAAAGSTAQRGPLALMPMHTQAVTAAIFHPNDATVAYSASEDHTVKTIDLTTQREVSRLTTLHPILCAAALPATSLIAAGSSARHVTLLDPRESAAETATMTLRGHVNFVVSVAPAPDNDYSLVSASWDGTCRIWDLRSVRPGTADEGGGRVSEPVYTIGREWLRGKKLPPAGEGVRVMAVEWDATWGIVSAGQDKKVQINNGKGLLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L166</accession>
    <name>A0A367L166_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase RBP11-like dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_6245</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L166"/>
    <dbReference type="STRING" id="1330021.A0A367L166"/>
    <dbReference type="OrthoDB" id="10248581at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06926">
        <property type="entry name" value="RNAP_II_RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037685">
        <property type="entry name" value="RBP11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I,II,III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946:SF16">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RBP11-like dimerisation" evidence="6">
        <location>
            <begin position="168"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI08183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="275" mass="30955" checksum="B489D65969648EAC" modified="2018-11-07" version="1">MNAPDRPSFPLSETVEIRGLARQDDFKCRPEGAGDGAANSQRAIAPDCRCQQLVNNLWEKKKHNHATLFLPLHDAFPRLHLIKTASLSPHHHPASQTSPSLSIKIPKISVMAGCNIKHFNIQDNVFELFLLAEGEKKIEEKVYSGKPPFFDSAVAPLLTPPQGMSNTSDFILNKEDHTLGNLLSEHLKLHPNVYMAGYKRTEHVLSLRTRLAHPNVPQLFIRVQTDGSKTPREVFCAVCEKLINQLESLHQAFTREWELRRITNIGEQAMQANGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L183</accession>
    <name>A0A367L183_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Hydantoinase/oxoprolinase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_6349</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L183"/>
    <dbReference type="OrthoDB" id="5404895at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.390.10">
        <property type="entry name" value="CV3147-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1610.10">
        <property type="entry name" value="CV3147-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048350">
        <property type="entry name" value="S-Me-THD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024071">
        <property type="entry name" value="S-Me-THD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010318">
        <property type="entry name" value="S-Me-THD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027479">
        <property type="entry name" value="S-Me-THD_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF10">
        <property type="entry name" value="HYDANTOINASE_OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20906">
        <property type="entry name" value="S-Me-THD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06032">
        <property type="entry name" value="S-Me-THD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160991">
        <property type="entry name" value="CV3147-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="3">
        <location>
            <begin position="5"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="2">
        <location>
            <begin position="206"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="S-Me-THD N-terminal" evidence="4">
        <location>
            <begin position="638"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="domain" description="S-Me-THD-like C-terminal" evidence="5">
        <location>
            <begin position="801"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="573"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="579"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI08199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1027" mass="109325" checksum="6E8FDD83CE307B7B" modified="2018-11-07" version="1">MSLYRIGVDVGGTNTDAAILDINALDQPGQRGVLASHKTSTTTDITGGIEAAIRAVVEASAVDQDRVLSVTIGTTHFINALVEADARRLDRVAVVRLCGPYTRQLPPFSGFPVGLRRILDGGVHYIDGGLEMDGRQIQKLDPDQVRRVAAEVVAAGVGAVALVGIFSPLDHDGLHEERCRELLLRHVPGLRVVCSRGIGSTGLLERENATILNAAILRTARRVKTSFRRAMHRLRLRCPLFLSQNDGTLIDADVAAELPIKTFASGPTNSMTGAAFLAGIDRAEPPDGNQAGDGPQVLVVDIGGTTTDVCALLPSGFPRQAPGFVDIGGVRTAYSMPEVLSIGLGGGSEVVVEQDEDGGSASSSSSSSDPHHHRRPVCVGPTSVGHRLREEARIFGGSTLTATDVVVAAGRADLGDAALVRDVPKPVVKLACDDIRRQLEAVIDRMKVSSAPVHVLLVGGGALLVQGELAGVEKCIRPVHQAAANAVGAAIAKVSGEVDSLEVLGRRDVKDIIDAACRRAVDRAVEKGASRQDVRVVEIHKQPLQYMSQETVRIQVRAVGKLAIPGHDTVPSWSNNIAVDDDDDDDDDVKDEDDNDDGARKISIPDALRPTTKPTLAIDLAAYRPDVRAGVWYISEVDLELIATGCGVLGTGGGGPTYYEYLKCLHSRRGPGGDRMRVISPRSLADDDLVCFGAWYGSPSVINERIPGGGELAAAIDAVKRVKGFDSFAALYLDEIGGGNGMCTFPGAVHYDRPVVDGDAMGRAFPTLYHFTFSVYGYSLTPCTLTDAVGNVFVALEASSPYRLETVIRTVAVELGLSCASSLNALPGSAIKAHGVPNTISQAWFLGRAVHMARRSKTSYVDAIFDVCAGKLLFSGKIIDVHRYIGGGYTMGAVLLGPLREEERESPMNASRQQVPKDRHMIVPFQNEYLYAAYCDAQGSESSRDVVCTVPSLISILGQDGEAIGSQDLRYGLRVNVIALPAHPLWRTPEALKVGGPEGFNLDMPEVGVETPHEFTGARSVIDEFGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L196</accession>
    <name>A0A367L196_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_6284</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L196"/>
    <dbReference type="STRING" id="1330021.A0A367L196"/>
    <dbReference type="OrthoDB" id="3365616at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22952">
        <property type="entry name" value="ART10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF166">
        <property type="entry name" value="ARRESTIN (OR S-ANTIGEN), N-TERMINAL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G02050)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin-like N-terminal" evidence="2">
        <location>
            <begin position="101"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="574"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI08191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="626" mass="68312" checksum="5672224B448EA699" modified="2018-11-07" version="1">MTRQVASTLTSQPQQASSRAAGLWGGPGGRERVDQTPPAPASVTEACHSLFPFAQDALSQQQKETENKNVVDSHLSPLIWSGRPGSAEAKSKEEIGKMSLRITIDQRPEFYTNLDHVVGRVVLSLNRAEQVGSIVVKLEGESITAHQVPNPFELDANGHPPPAMPGPPGSVVVENHKILYRIQQVFPDDYHSSSSNPYGAFPLQPGEHEFPFRFKLPVNNACSDNVAMARMGGFNSGGGLFGMGGVRLMDGTKQLYLRHVTRTLPPSLTGYPMDGEIRYFIKVTVQRPGFLKENWRYQTGLKFLPIEPPRPPKSGQEAFARRPFTFRPRSGPSYPDMKRSKKGEKDSGLPTSPPPPPPNIEISARLPHPPILACNQPVPLRLIAKKLSKCPDQVYLISFQLDLIGLTEFRTHGLNKVKINRWVVVSNSNLNIPVTSSPHDDVGDELVLPDELWRSRPLPNTVAPSFVTCNITRRYQMEIKLGLAWGKPGTLKDPLQPQTIYLSLHFSHIDVYSGITPPPELVEAAKSQKPGRVTSGRPPLPARPSVTGSSASTGTRPSSVASSSHDPLYPPQLAPGQSPASSDAAPPSYDEAMAENLAGPFDGTRPRPAYSGVTNENAPSTMPEKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1C3</accession>
    <name>A0A367L1C3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Golgi to ER traffic protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_6305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GET4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1C3"/>
    <dbReference type="STRING" id="1330021.A0A367L1C3"/>
    <dbReference type="OrthoDB" id="10252405at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045048">
        <property type="term" value="P:protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007317">
        <property type="entry name" value="GET4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875:SF0">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04190">
        <property type="entry name" value="GET4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI08218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="328" mass="35661" checksum="9586821A00EEC739" modified="2018-11-07" version="1">MANRVERIVSRLQQKITEGDYYEAQQQTRVAASRHIKTRNWPAAIDILATVAQALLRAGQGGSGGDLCVMLVDVYVQAQLKPDAESKGRLLTCLRLFEPGEPTRKRFISDMMSWSAKFGDYPAGEPELHHVVGSLYADEHEPYEAERHLILGTKDSPEVLAKMEYSWYKEGDAHLAPQFAGRAILGYLLVGNLRAANNCHRVFTSALSSDNAGLGVQDVSSASCDLRIFPSLPLLNFLGLLLLTVPRGAPEIFRGLVGKYSTLLNDVDGWPEALEQVAELYFGISRPRQSNPLMDMMSGFFGGGAGGGGGSQRRGLRGVEAPAPAGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L276</accession>
    <name>A0A367L276_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_8947</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L276"/>
    <dbReference type="STRING" id="1330021.A0A367L276"/>
    <dbReference type="OrthoDB" id="2095648at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027040">
        <property type="entry name" value="PSMD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223:SF2">
        <property type="entry name" value="F-BOX AND WD DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G11400)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="73"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="858"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="934"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="866"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="956"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="981"/>
            <end position="994"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI08322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="994" mass="108070" checksum="C86064D21E5F16BC" modified="2018-11-07" version="1">MQQVPTESSEQHHQSINALDNDPNRHHGPCLCPRLYVSPCPVSVDHVGDQLGRLQTNPDCGHAPTPSTGVVRRESLDKLPNEILTQILSHLQPDSHAAVALVSKRFYSLVTSPHAWRMAFFRFYAGHTLIDAGPQERIDPALGLVQPRTRYFGRLTALASWRSEYLVRTRLIRCLMRGKPASRSGFIGSSGRAAGKNSAVLTYDTKLYWPVTSIHAILSNRQKPPRVIHGAARAGVATISDPTTGKVEKWGLEDTFAAAQPHPTALLYGLGDGPATVPNVMDVSQPYGILVGEGFPGGRAHFRGAGDMSGRYLDAGISDVALPGVPSIPQASEAICSVWIAKSSITPATTQSRCGIFTGSTLGIVTAYSLGRWDAAGSRRSDGDMTARWVVSPGVPIIALKVDDDYSQARKSASRMWAVALNALGEVYYLTETPVCTESPFAAEDAAERAWLTGRSVQWRLIQATQRVQRPDEPVCGVARQTFGIATVDRERRPVEMVRYGPAYFRRLYEGWDMQRRLEVDFAADDGNGAGEGVFVIDCGLAADRSARVSRWSRSTMICEVGPEPESSVPCASAEADVDGNRSARVHEWRYSLLELGGHGQAFISASSMDCSTFSLLTLTEDPLHAPRETSTQDGTTASSIPGRRARFIAVGTGSGAIVVWNARQRHADGMQPVRIIQTQSPEIRSLAVSALYLVHGGSDGLVQAWDHLASTTDAIRTIHVRSSGRRHRHAMGPDLTWSESNHAAAGAVYLDPDPTVLRGVVSLGALVRFWSFSASGQPASRKFRHRHSDMHGRLASRRSGGAVSVYIAAEEAEVRREKEQRAREQARLHRRFGALGDLTEEEALRYAQMVSQETFLQDERRRASDSAADASFDTASSLDETAVDTVTPPPAWTATESHLEQQMQQALRLSLLEADSPGGFEYAIRYKAKGNRKGKRRTWASPTARGGPSQAAPSWEEEGEEEEEEALARALGLSLQDQASSSSSSSPSPSSTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2G4</accession>
    <name>A0A367L2G4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_4718</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2G4"/>
    <dbReference type="STRING" id="1330021.A0A367L2G4"/>
    <dbReference type="OrthoDB" id="1875589at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23702">
        <property type="entry name" value="eL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039660">
        <property type="entry name" value="Ribosomal_eL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002784">
        <property type="entry name" value="Ribosomal_eL14_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01929">
        <property type="entry name" value="Ribosomal_L14e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL14" evidence="4">
        <location>
            <begin position="58"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI08621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="147" mass="16783" checksum="125FACE1D49A8F72" modified="2018-11-07" version="1">MGEAVIEGSNWRLVEVGRVVVITGDHPYSGGLAAIVEIVDHKRVLVDGPSPDHELAVPRQCVPLSKCLLSQFVVEGLLRGSRHGTLKKLWEKSEIDAKWKKSNWAKKRDQLKRRKSLTDFDRFKVMRLKKQRRFEERKALAKIKASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3B0</accession>
    <name>A0A367L3B0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5151</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI08921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3B0"/>
    <dbReference type="STRING" id="1330021.A0A367L3B0"/>
    <dbReference type="OrthoDB" id="4509994at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI08921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="116" mass="13578" checksum="D418A29DE282260E" modified="2018-11-07" version="1" fragment="single">LKNKIRTNKTTFRDEEDRIGFLFRSLEGKARKTLKTWYDFIERPFSGLAEIIYLLTKTKDNSLSYEDFYSYIKDSAVKRLDTELVLPNNLPAFAKYSLLILLPKTPLLNRQIDPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3N4</accession>
    <name>A0A367L3N4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha-methylacyl-CoA racemase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3N4"/>
    <dbReference type="STRING" id="1330021.A0A367L3N4"/>
    <dbReference type="OrthoDB" id="16747at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="entry name" value="formyl-coa transferase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050509">
        <property type="entry name" value="CoA-transferase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228:SF5">
        <property type="entry name" value="ALPHA-METHYLACYL-COA RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228">
        <property type="entry name" value="SUCCINYL-COA--D-CITRAMALATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="395" mass="42915" checksum="61AF1E2FDD1FCAE6" modified="2018-11-07" version="1">MAAPLQGIKVLEFAGLAPGPFAGMLLADCGATVLRIDRPGSEVAAATDMLARRKSSMTVDIGTEGGAALIRALVARAGIDVLIDPYRPGVLEKKGLGPDSLRKLRPQLVFARLSGFRRTGRYKDMAGHDINYLAVSGLLNALGRADEKPYPPLNLVADFAGGGATLVLGVLLALLHRSRTGSGQVVEANMVDGAGYLGTFSRISRKMPPPLGGSDRGRNLLDGGCPFYDTYETSDGLYMSVGAIEWRFFSDLVRLLGLSGWDDDETRMDRKAWPRLRAEMEAAFRSRDRKHWETVFDGSDACCVPVLDFQELETDARREGFLSPVVDLHQSPLIPPAPTAHTCVVPRPGYDHVPLSLDTGGQELVREWLGWESGKQYHRLEHGGFVLDSGFSSHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3S9</accession>
    <name>A0A367L3S9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_5083</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI08862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3S9"/>
    <dbReference type="STRING" id="1330021.A0A367L3S9"/>
    <dbReference type="OrthoDB" id="2426396at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39599:SF1">
        <property type="entry name" value="GPI-ANCHORED PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39599">
        <property type="entry name" value="GPI-ANCHORED PROTEIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="357"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="147"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI08862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="384" mass="38106" checksum="7DCE149958D6BC09" modified="2018-11-07" version="1">MASLFRLPPGAPTALSKMPFDAGVKILPHHLAFAPAADALLLAVAASCPAGMNSCADQKSPNKCCQKGTYCTAVPDASVEHVACCPDGARCGGQVGTCPADATSCPSELGGGCCIAGYVCRGLGCVPRDSAVESSAPTPDAYRPVDTGSGTTSLVVVVGPPPTQSDTPTTSLSLASSDTTIITSSSLTTSDTLSLTTSDTLSLTTSDTATSSDAGTSPGPPWRPTGPSPPPPTTTTTADEPSTQTGCPTGFYGCLATHGGGCCRTDRDCHTHSCPATSTSILIASNGATVVVPGGRSPQATCAGGWFACGSSDDDGCCPSGYQCGSASCVAGGAGGSTGSVGKQPARTSGAAGARKLLLLLEGWFYCYWILVMVVVVVVGVVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3U8</accession>
    <name>A0A367L3U8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">rRNA methyltransferase 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_5065</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI09094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3U8"/>
    <dbReference type="STRING" id="1330021.A0A367L3U8"/>
    <dbReference type="OrthoDB" id="270651at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18105">
        <property type="entry name" value="SpoU-like_MRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047182">
        <property type="entry name" value="MRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047261">
        <property type="entry name" value="MRM1_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013123">
        <property type="entry name" value="SpoU_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46103">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46103:SF1">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08032">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00967">
        <property type="entry name" value="SpoU_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="RNA 2-O ribose methyltransferase substrate binding" evidence="10">
        <location>
            <begin position="111"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI09094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="450" mass="49394" checksum="089640C99F40BE86" modified="2018-11-07" version="1">MTGLRRTAKAEETTSRGRAACRVGSPTYLTLLAGLSDPLSLNELTNNLTGVTSVKEAKDLVNWTDMINKKTNHAHHNRATTPRIKPHLLRQADRGYGVLTEVKYTASGSIFIYGKNCVKAALRAGKRQFYTLYMMVDKNRGMTAEDTIIHRMAAGRGVSIMRVEDYKRGMLDKMSGGRPHNGYVLETSPLPQKPILGLGEVEESADRLGFYVKLDHQSKEQERINGKDNFIPRMDGISPKPFILLLHNVVDPGNLGALVRTAHFLGVDAIAMTKTHSATMDSVALKASAGSAEEMTLFSVSSAVDFIEQSKPFGWRSYAAVAPLSKATLSRGVEPPLTAGEVERTDPLIRDPCILVLGNESQGLGHAIKDAVHHHVTIPGWRPYRTVDSLNVSVAGALMCQSFLKASHASEGMIEAAANRWKKVHVKPNRRPIRPEPPLQPQTGDFGWLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L435</accession>
    <name>A0A367L435_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_5037</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI08972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L435"/>
    <dbReference type="STRING" id="1330021.A0A367L435"/>
    <dbReference type="OrthoDB" id="3353407at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021822">
        <property type="entry name" value="DUF3405"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36205">
        <property type="entry name" value="CHROMOSOME 19, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36205:SF2">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11885">
        <property type="entry name" value="DUF3405"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI08972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="797" mass="91189" checksum="310AA47D2CBEA353" modified="2018-11-07" version="1">MGKMLNPPGRRKLGLLPRPRTILLLAVAAATSYLILFSGHAPRVHIVPYLRDTPPSSPSSSSSSSSPTSSHSDELSATKAEWHVEIDDLRYWRDPDDPENPDDVLPGYETDGKHREPGDVGRLQHEKNLRKMWRYLYKTTANLKTSNLVYGNTLESLVLKENRSDQLRKPLRDDPRVDLIFAEDKPVRFDPYPDYNSDTWTRHGHAAYIPCKGPTGELVEDLLVFKGRPEKWPASKFGSYDVLGMDANLCWERETRLGPFGLVQQKKKVGGEYKPVDWDNVNWGDLQQRCLKLNAGRFDMHRSQKNDYLAAYPETAEPVPPPAEQMAQLRHQHTAGHVSSLASSGAAVPAAPAAAAVHYHPQQQTRRSTDEANRDGGALKVKEKRTAVLLRSYTGRKYSENDKQVIRALVSELSLKTGGEYEVFLLVHSKDRNRRIFDDHEAYLSVLRDNVPAEFRGMTVLWNDDQVGNIYTKLTDEEERSVHTAQWLSVQKFSHDHPQFDFIWNWEMDFRYTGHHYDLLDKLAAFAKKQPRKYLWERNERWYIPEYHGDYDTAFREQVARRHGDDTVWGPVDLPFINPVGPKPPVPSHDDDDYEWGVGEDADFITVGPMFDPIDSQWIIGKHVWGFSDGRHKSVDLPRRTTIVTQSRVSRRLLDAMHVENMRGNHVASEMTPQTIALLHGFKAVFAPHPVFMDRDWTGPFLNSWFNPGPKGECGGRGSPMGWGRERRYQGTTWYYRAEPPNRLYNNWMGWPDTGMGGPAWEEQHGRPCLPSVMLHQVKDTEPTKPDHQTGFDLAYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L452</accession>
    <name>A0A367L452_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Acyltransferase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_1440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L452"/>
    <dbReference type="STRING" id="1330021.A0A367L452"/>
    <dbReference type="OrthoDB" id="5819582at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050879">
        <property type="entry name" value="Acyltransferase_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028:SF134">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="470"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="3">
        <location>
            <begin position="95"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI09200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="518" mass="59386" checksum="3494D2AD4B109FAE" modified="2018-11-07" version="1">MATHSPCHDDRMGLVAPSDTDSDADTEHDAAAPFLTKLDPPAKPRLSLLAAVAAFLSSTPWRLLMLRLVNFLLPSFLQRHHHREQTGSVRLSPTAYLDGMRGLAALFVFFCHYTYQAFFIARGWGFAGDNYDFLKLPFLRLWYSGPQAVCVFFVISGYALSYRPIKLIRTRALPDFSTTMSSLVFRRGLRLYLPTAISTLLIVFLLRLGAYEWTRDFANDRTYMHNVVEPHPARMDSTYDQLRDWVAQMYRFIHVFSWDMAAGRLPYDVHMWTIPVEFRCSLFLFLVIIGTARLRTRFRLLVVVGVMWFTYLHSKWEVLLFLCGMLLAEWDHIRGAHVCPPALPQDEKAAAAPGRPLWKKISWTVVSIVGLYLMCQPDEGGSDTPGWRMLTSMIPTWWEAEEYRFWQSIGAVVFIAAVGHSSGWQSLFNHAAIQYLGKISYALYLMHGPAMHTVGYHFEKWAYSLTGVDGYWYNAGFVLGACFCVPTVIWWADVFWRMVDIPTVRFAKWVEGKCIAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L487</accession>
    <name>A0A367L487_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Imidazole glycerol phosphate synthase hisHF</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="12">Glutaminase</fullName>
                <ecNumber evidence="12">3.5.1.2</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="12">Cyclase</fullName>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L249_1537</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 12">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">In the C-terminal section; belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="12"/>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L487"/>
    <dbReference type="STRING" id="1330021.A0A367L487"/>
    <dbReference type="OrthoDB" id="10254903at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01748">
        <property type="entry name" value="GATase1_IGP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04731">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000094">
        <property type="entry name" value="Imidazole glycerol phosphate synthase hisHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000039">
        <property type="entry name" value="Imidazole glycerol phosphate synthase hisHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00278">
        <property type="entry name" value="HisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004651">
        <property type="entry name" value="HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050064">
        <property type="entry name" value="IGPS_HisA/HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014640">
        <property type="entry name" value="IGPS_HisHF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010139">
        <property type="entry name" value="Imidazole-glycPsynth_HisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00735">
        <property type="entry name" value="hisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01855">
        <property type="entry name" value="IMP_synth_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21235:SF2">
        <property type="entry name" value="IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE HISHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21235">
        <property type="entry name" value="IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE SUBUNIT HISF/H IGP SYNTHASE SUBUNIT HISF/H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036936">
        <property type="entry name" value="IGPS_HisHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 12" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 12 15" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="16">
        <location>
            <begin position="8"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="360"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="398"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="472"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="498"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="521"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="13">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="13">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="13">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="248"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="14">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="467"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR036936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR036936-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR036936-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCI09245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="557" mass="60107" checksum="DD278109E39AA059" modified="2018-11-07" version="1">MAPPTVHLLDYVAGNIRSLVNAIEKVGYQVEWIKSPDEVAKAEKLILPGVGHFGHCLSQLSQANYLSAINKHIADGKPFMGICVGLQALFQGSAEDPSVPGLSLIDGSLDRFDDAAKSVPHIGWNSANVVGGRQMYHLSPTTSTKYYYVHSYKYPYLPGRLEEQGWTVATATYGSETFVGAVARRNVYATQFHPEKSGVAGLLTLRSFLSGKGAASLGRPFPESDMASSSSSLVANDGLTRRVIACLDVRTNDQGDLVVTKGDQYDVRDNDSSVRNLGKPVDLARRYYEAGADEITFLNITSFRDCPVADLPMLQVLRRASTCVFVPLTIGGGIRDTSDATALDVATLYFASGADKVSIGSDAVIAAEQYYARGRVLDGKSSIELISRAYGVQAVVVSVDPRRVYVSNPDKDATHHHLVETLFPGPEGESLCWYACTIKGGRETRDLDVVQLAQAVEAMGAGELLLNCIDRDGSNSGFDLELIRHVKAAVKIPVIASSGAGEPAHFEEVFNETSTDAALGAGMFHRGEYTVKQVKDYLEEKGLLVRPFDGDLDLAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4T0</accession>
    <name>A0A367L4T0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3662</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000015">
        <property type="protein sequence ID" value="RCI09430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4T0"/>
    <dbReference type="STRING" id="1330021.A0A367L4T0"/>
    <dbReference type="OrthoDB" id="1060854at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20558">
        <property type="entry name" value="CYCLIN_ScPCL7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF94">
        <property type="entry name" value="PHO85 CYCLIN-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="520" mass="55680" checksum="681837F6E13DF154" modified="2018-11-07" version="1">MAAVIGDLVADVSRLRDLITNPRQRSRSQTLDASSPRRSASRLWPAPATPPRSSLRHDAEARPALSAAARGDSQEDDNSSRPHHLHRASSALAPRTAPRTGPSGGGTSRIPSPPSSRSPSAVATGPRSTDDDQGVQSMASKTQGGSQPLAPPDTASMSGSRQQQQPSPPADDVEMTGSHTSSEAPAIPSPTHTLAPPIGHSPGQQVVVHVRDLSHVQTLASTQGLDGAAAGRTKYEISGMPMDDVIEMVAALLTKIIATNDLQHDATQRSASHGSPMMACGGSPISHSVFAFHGKNVPAISICSYLSRIHKYCPTTFEVFLSLLVYFDRMTERVNDAIMKCGKAGRQSRAASEPSQDGTPRKDTPMGGEGRDETDLDIADDDDDDDDDEEEDQDEDEGEIVGRADNHDDGERIVVPDVHPSSSRPVTYFVVDSFNIHRLIIAGVTCASKFFSDVFYTNSRYAKVGGLPLGELNHLEIQFLILNDFRLAVPVEDLEAYATMLVEFYAREVLTARAAPTPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4Y2</accession>
    <name>A0A367L4Y2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyltransferase 2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_3796</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4Y2"/>
    <dbReference type="OrthoDB" id="2016523at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22189">
        <property type="entry name" value="PGAP4-like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029675">
        <property type="entry name" value="PGAP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31410:SF1">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31410">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 246"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016751670" description="Glycosyltransferase 2-like domain-containing protein" evidence="2">
        <location>
            <begin position="27"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI09479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="47915" checksum="E9275FD2A3C01B69" modified="2018-11-07" version="1">MNLAHLNAGFWLVWLSLLVLCYFNSSDDPTSLFYDRTRAYEQKYSLQRAAEAKDYLQHVTDKIEQAEPDRRLLCIGIPSINRTSESFLAYTIATLTDTLTAEERASIRLVVLLADKSPESHLAYGQPWLEEIADEVLLYGGEGSSWGNHSVYRTVPYNLYTEGPGRGTGRVENMRLDHSLLVETCRDYKSPYFALIEDDVVASPDWFTKLKKGLEYVESRSAGQTGDWLYLRLFYSEIFMGWNNEEWLSYSQNVFFVYTAVLVVFLVKMLMRKRNSAPGPARSSAIFAALLLGLWLPALIALYFVAGRISMSRINPFAWNWHPAREMPNYGCCAQGLVFPFRHLEGVQALFRRPPYAFAGDQILEDYARDHSLSKWALEPSVLQHVGLKQSSAGDQRAEVWNFSFERKQLKKAHRSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4Y8</accession>
    <name>A0A367L4Y8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mediator of RNA polymerase II transcription subunit 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Mediator complex subunit 12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_3964</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SRB8-11 complex, which itself associates with the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367L4Y8"/>
    <dbReference type="OrthoDB" id="20828at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057344">
        <property type="entry name" value="ARM_SRB8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019035">
        <property type="entry name" value="Mediator_Med12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46567">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46567:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25326">
        <property type="entry name" value="ARM_SRB8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09497">
        <property type="entry name" value="Med12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01281">
        <property type="entry name" value="Med12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med12" evidence="13">
        <location>
            <begin position="291"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1316"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1327"/>
            <end position="1355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI09496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1525" mass="166216" checksum="DA005BCA56769B63" modified="2018-11-07" version="1">MTSRPPIGVLPRQPQRAPASHSAVQRPSKHHQRSLSQQYLAPSASPAVRRDSHPEAPGEPSDVPHPAAAAAAAQTRHHASTPRRGTSKLRLELSNNDWDPDLATTSDSPQILTPSRAAPVLAPPVSDADKVSPAQSRGSQYDDNPPIPLPKRRLQLPERAVSTPRPCTAVVAPTKKDARPRPYTVEVPSSAPRFVSIHKHDIPNRDPFSKGLHTGHADFFPWSGHHHEDEWSSEAIQKGTWDRGAQNETSSARLAVLPALKQKSGLNALSTIFMGVMNQRRFRGQILSPSTFKPPPRVTLTDTKREVWLKDLANPTISLRRLSRTIPHGIRGRTLLDQCLNKNVPTERAVWLAKCVGANEIRAFKRKGAGGAFVMGGESKWVRDWTVFVEQFVETVVSAFGEPDWKTRVTYAIRLATNLYSEHLMDRDHYLDWITSNLESSPQSRMPMWILIAQITWADLVRSRKYGRRLVYTLLAQLNNIHNDPDRDILIQLSSQLTGLLKTLLRSNPESFVAPKLWPKHRDALKAFLAPDDALSQDAWQRVDGRNARLSVGGCNTASPPAGRQHLIKLLDSTIQGHTDRELASKCLTVTNDKAELVKTLVEWATSVHRPGLAKLYVAVSLIKAWAASDATSVIVDLLDHVPSSNRLRKKAIFHLVSELIRAGLFSVPQYIKWLIGRGGLHDAAEIDADEGPCSSRLLVELPIHCLSESQRLQRTNLLRRAGQYSTAEEAKDMANALRCVDGSLGLSQHLGNKDGASTKCLSMPKLLRRISNSSKAVQTSIGAHLRDVLTPELLAKVEPVVALSTFSSARLVLETARDFGSLSQVLKSYAAASDVEVLAACADTVNSLLDVFLAMGSADALFSALTGRLKSLNREQAAAARPLLVALASLARRLPNRGAVAQQLQRELAQSERSKAIDACSPVSDSMALQAQNGESEVSEQIDKLLASGNTVDPPTMNRLFRNIIPKLEAGWAKADGGRRVFASLLARLRIFDAQHFDKLMADWVSHVGTLKDRPRLLELFPLLISLGCLSIPTVLRSANSVTSTDPGSPSDASSVYLQELLQLIVMKLPRAGRLDTAETYRFEIQQRTARLEHGGALLSLIRNAVAEYAAVVGSRKDCPLDDTFCRDCLVETLRYLVVTDSSAVAKVLDAGTLAAGAVEFVDQMVTRLLAPEGDGGSQESFDQLLSLSNELTMPFCQLKLDVYLSGAEKSSSRLEGFARAMDRAIEARNIAWTKMLPCLSQDITRSLSMQAHARFLGLIPSLKSDEEASSEQAVDLAENLLGVIEAITWPKSAQLTAALAEKLCDLWGSYLEPSGRRDGGGGGGGDDDDDDDDDDDDDDDDDDDDDDDDDDGDGAGSQDDVVRARIILVLCGLLLELDSRRRGSLSQQVLDVATLLVDGLPDEARMQCAKNILFLSGGGAGGGAGGAGGGGNTSSDPRLYYLFSLQQPTWAENLKLAHKERASIAYSAAARGMSTLYGIGPASSERLSPYVLRRWEVLSEPTPNVGENDTSLSLGLFEAIKMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L593</accession>
    <name>A0A367L593_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_3724</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000015">
        <property type="protein sequence ID" value="RCI09392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367L593"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF3">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03403">
        <property type="entry name" value="PAF-AH_p_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="1106"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="633"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="642"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI09392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1317" mass="145718" checksum="293180890C8EA020" modified="2018-11-07" version="1">MELSSAFAQLPHPTSITLSSSNMIRLSLASLSSRGSLAPAPSKVAALLSRISPVPAFPDYTGPFKVGTIDVEVPIDHLDSPAPTPLNAADIATVQFRVFYPAVDDSADKFISWLPVPRRQHVSAYSQLVGIRPALADFLSEEEVVLTTASLLPRHLYCTTIPAYSNAQLRQPETKSSPRWPTVIFSHGLAGSRHMYSYLAGSLASHGVVVFCPEHRDGSAIVSFIRDETSSRRAVSYVQMSHKPSPEVYQAREAQLRIRLWELGLVHDAVLAMDVGKELASRDPSTPSLQSFAGRLDVQEPGHIIFAGHSFGAATTYQFLKCVYYADHPSLAAMANPIYSPARDSSLCKQVTERTVTMLLDMWCLPVMTPGSAPLLALPLPAYADVPTAPGGRALLAVESEAFYKWTDHLRTKALLLCPEPSARVVTAQMYERPCGVRLPEPNFFYVVKSAHLSQSDFGILFPWLSKKIFAADEPERALRLNLRAQLQLLRANDIVVARTSTGDLVDGPRRAENKAGVCDDEAILDRSGHHVVDHWRRIDLVGLGGAVETEAEPDSASASRLFFKMSDSPHDDAYSTDAWRLLFGPHGYKADFNSLPLDHFHLLLLLIFSILIIVIFRPILIGSSSLAMSDAEQQTRKSDDSSASAVVVSPVAEEKPTEEKAMVGLLAQSKELYAKIDEHRNRSWTDKKPDDFEEASENEETAKYAVIVRKGQRPSRELQKPKDADGKALVIDSLIIQSPYLKRVLSDVLEDYPGIITDVARLKLWAPFECLVHRWDRLEAAARDPSLEGPAKEHLQLFMEILRQELGPVIQLRDDYFKNRAAAFEHIWTLFPPGCTVLGLKNGKPVAAKFRRGYQVETTCGKMYFLQCRIIDWDGSTMGWTDLNQQIPAFIGTMPFASLPCHPLEYDDDAAAVKRMLMDRGRRFEALAGYCYRAYRGVALWHPEPRKSIRETVQSRIVVDGANWEKENFDHQVEITPLHREASRTNNISGRARRYGSFSSVDSSCSSSPPFGGGPVLDGGEAGVGRPPLTDELLLVTSPMVRGYALQNKRWMEFFVDDVSDVQFDEHAFSSLVLPTDKKELILAFAQSQARYKDAFDDVISGKGKGIIILLSGGPGIGKTLTAESVAEEMRVPLYAMSAGDLGSDAYDVENNLSRTLAMVADWNAVLLLDECDVFLEARGPHDLERNRIVAIFLRTLEYYQGILFLTTNRVRDMDPAFASRVHVSLEYPALDAGARAAVWRSFLARCVVDVANPTVRGDGAHDVGEEDIHALSALDLNGRVIKNVLKAANLLACHRGARLTMEHLRTVLKVEGHSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6I6</accession>
    <name>A0A367L6I6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_8744</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6I6"/>
    <dbReference type="STRING" id="1330021.A0A367L6I6"/>
    <dbReference type="OrthoDB" id="4094614at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038843">
        <property type="entry name" value="Sed1/Spi1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35523">
        <property type="entry name" value="CELL WALL PROTEIN SED1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35523:SF1">
        <property type="entry name" value="CELL WALL PROTEIN SED1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016629110" evidence="2">
        <location>
            <begin position="18"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI10034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="516" mass="51814" checksum="96B6D4B192C062F4" modified="2018-11-07" version="1">MLPKAVLISSLAGFSMAQFDQVVSKVDSIFSAAESAVDNKASDIVSKIESKTSIISEILSDKTAAASSAPAPASSASSAPAANPTTTTNEPVSTGMKAGSYDQPTPAPGPVTVTTTRVVHDEYVTWCPEPTVVTMNGKFYTADKPMHITIKDCPCTIVEPVPGGGSGCSGPECGGGGGGGKGGCSGPECGGGKGGPGNGCSGPECGGGNGKGGPEGGKPGCSGPECGGEGGAEGGKPGGCSGPECAGGPEGGKPGAEGGKPGAEGGKPGEKEACSGPSCPKGPEAGKPGAEGGKGGDKGACSGPSCPAGSGNGYNNYEKTVEVASAHAKSIAYALAMAAAGVVSYLALITGRTQHYRHTLGDQGYSLYREQLQLSPAITRPAPAIGPTPGFPTPAATATRPHTEPQSPSRRHYLRKRLLVVPRESITTSGADPSWRSLPSFDPLAATTPAKVKGLSRSCVSEQIPIKMHMDSAMERIKGQVVHQQQFAMEILLCHAPAVEKGARDIDESVRIRLPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6J3</accession>
    <name>A0A367L6J3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6J3"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="68" mass="7450" checksum="04E3F8F3CAEA7A84" modified="2018-11-07" version="1" fragment="single">MSVYISKEEEGRTTTTTTISKNKNMVTGNPLDSKKDDELVSSEREGSCAPDPRGLIARLKKKRGLIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6N5</accession>
    <name>A0A367L6N5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">H/ACA ribonucleoprotein complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Nucleolar protein family A member 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_8547</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Common component of the spliceosome and rRNA processing machinery. In association with the spliceosomal U4/U6.U5 tri-snRNP particle, required for splicing of pre-mRNA. In association with box C/D snoRNPs, required for processing of pre-ribosomal RNA (rRNA) and site-specific 2'-O-methylation of substrate RNAs. Essential for the accumulation and stability of U4 snRNA, U6 snRNA, and box C/D snoRNAs.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
            <location evidence="1 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6N5"/>
    <dbReference type="STRING" id="1330021.A0A367L6N5"/>
    <dbReference type="OrthoDB" id="1924699at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000002">
        <property type="entry name" value="NHP2-like protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002415">
        <property type="entry name" value="H/ACA_rnp_Nhp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00883">
        <property type="entry name" value="NUCLEARHMG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="11">
        <location>
            <begin position="19"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI10069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="126" mass="13399" checksum="9791455F98C36040" modified="2018-11-07" version="1">MADDTNAAWPLADAQLTEEILNLLQASTHIRQSKKGANEVTKSLNRGTCEIAILAADTTPLAILLHIPLLCEDKGTAYVYVPSKTALGRACGVSRAVIAASINTNDSSELSGQIKALRDKVERLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L713</accession>
    <name>A0A367L713_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">D-3-phosphoglycerate dehydrogenase</fullName>
            <ecNumber evidence="12">1.1.1.95</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L249_8515</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="EC" id="1.1.1.95"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.95" evidence="12"/>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L713"/>
    <dbReference type="STRING" id="1330021.A0A367L713"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00196"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010960">
        <property type="term" value="P:magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04902">
        <property type="entry name" value="ACT_3PGDH-xct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04590">
        <property type="entry name" value="CBS_pair_CorC_HlyC_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12173">
        <property type="entry name" value="PGDH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.90:FF:000003">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000021">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000006">
        <property type="entry name" value="DUF21 and CBS domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.90">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045095">
        <property type="entry name" value="ACDP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029009">
        <property type="entry name" value="ASB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044751">
        <property type="entry name" value="Ion_transp-like_CBS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006236">
        <property type="entry name" value="PGDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045626">
        <property type="entry name" value="PGDH_ASB_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01327">
        <property type="entry name" value="PGDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064">
        <property type="entry name" value="METAL TRANSPORTER CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064:SF97">
        <property type="entry name" value="METAL TRANSPORTER CNNM-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19304">
        <property type="entry name" value="PGDH_inter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143548">
        <property type="entry name" value="Serine metabolism enzymes domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0520">NAD</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-0718">Serine biosynthesis</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="ACT" evidence="14">
        <location>
            <begin position="477"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="15">
        <location>
            <begin position="636"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1110"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="1129"/>
            <end position="1138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCI10211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1154" mass="122819" checksum="60A8F43DB749F8BC" modified="2018-11-07" version="1">MAPSADPDVSSQSARALILVPETISPDGLALLSPSFDVHVRPGLSPDELETIIPGYHGLIVRSETKVTAAVLRAGRKLKVVARAGVGVDNIDVAAATSQGVIVVNSPAGNIVAAAEHTIALLLATARNVGRADAGVKDGRWERSKLVGVEVGRKTLGIVGLGKVGLNVARMAKGLGMQVKAVDPYASADLALQTGVELVADLGSLLGEIDFLTIHTPLLATTMDLVGEPELRQMRPTARVLNVARGGVYNEAALLQALDEGWIAGAGLDVFTSEPPHSVAAQLARHPRVVATPHLGASTVEAQENVSMDVCKQVREILEGGLPTSAVNAPIILPGEYRKLQPVVRLMEQMGRLYTHYFVRSKGGGRKFEVVYHGDLACMTNTKPLFAALVKGLVASISDSNVNIVNATIIAKEKGIVISETYERQSKDHQAYSNLVTLKATADDGSEQVIEGYASDKRVYISKLDRFRAAFRPEGTLIILHNYDEPGKIGCVGMALGSHGINVHFMQVASLGVEAVEAQRDNEALMILGVDGEVGGDVLDELRRTEGVLDVSLREAAHPPTVFFPPSSYHRNQFNTLSKAFRGRICPYGSRSEMRRHGPSGAFTNLRPVVLGLGRLLGVAAAPLAARGADYDNDGEVAPLWVLAVASMALVLLGGAFAGLTIAIYLQVLSGDPAEPQHRNAKRVLNLLNRGKHWVLVTLLLANVIVNESLPVVLDRTLGGGVAAVVGSTIVPQSICVRYGLPIGGYMSKPVLVLMYLLSPVAWPTAKLLDWILGEDHGTVYKKSGLKTLVTLHKSLGDLSERLNQDEVTIITAVLDLKEKPVSEVMTPMDDVFTLAEDHILDEKTMDNILSSGYSRIPIFRAGNPTDFVGMLLVKTLITYDPEDRIPVRDVQLGAIVETRPETSCLDIINFFQEGKSHMVLVSEYPGSDHGALGVVTLEDVIEELIGEEIVDESDVYVDVHKAIRRLTPAPRAKRLHHDDGSPAVPTAAMAVKRPGDGSVLVDIAEHPDGPVLTVGSPGALSDTGGVAEEHHPKTAIFMKRRRSAGPDGKAERGTVPIKASLDEMKRQLRLGPANRAARPRNTRTNVFKIKQGLTTGPGTGSNGKLVAKAAAVESEETPLLPTANGGRPSAGGYGSGETGKKKPEGGAAAVGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L744</accession>
    <name>A0A367L744_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L744"/>
    <dbReference type="STRING" id="1330021.A0A367L744"/>
    <dbReference type="OrthoDB" id="3508416at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="22907" checksum="354BFB0C633D9536" modified="2018-11-07" version="1">MAVAAPEQRRQLHQASNSNKFSSRYHGMHTENNASADHLTPAQNCALWLTNLPSDVGYSELLASITNVGRIWCTFINLPDMMRHQTAAAKVVFSVPEAAQKLLNQSWTKTIVIRDHRVRVSHNRIKYPANDMPDRRSRVLLITGRDFFVNPDSLRCWFQHRFVFQEDRVIELIKAGGRAVRELSQPGANGRQGSRDGSSGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L772</accession>
    <name>A0A367L772_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L772"/>
    <dbReference type="STRING" id="1330021.A0A367L772"/>
    <dbReference type="OrthoDB" id="271745at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="355" mass="37204" checksum="7BB6A016F1637296" modified="2018-11-07" version="1">MSCIRSEQLQARRPFERNALIGLSAVPREAVPESEPPNAVVVVVVVVISGVLQREALPKGFFSIPATSLAQEAAAAAAAVSPCAINPLVNLPSAFESAATKRPSSLKHQTPPLLLTKRLNAFLHANQSPLLPTLLLATAHGKLLAHAGAHPVSTLRTHATVAASLLAIHTSASVEVPSALPGAARCPPSDESADDESAAAADDDDDDDDDDVDDDDHVAAITHARAQRRAAGKAVQPAAITVQLSGGTVVIRRLKCNLLFVAIGPSAQDYHPPQQHHHHHHHHHHHHHDNGDAGGSPSEAESMASAGGHTTSSLESVGAASVVAMRRHAGELTRWLDDRLGTLKVPREDGSIVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L783</accession>
    <name>A0A367L783_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_8573</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L783"/>
    <dbReference type="STRING" id="1330021.A0A367L783"/>
    <dbReference type="OrthoDB" id="446113at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12611">
        <property type="entry name" value="RRM1_NGR1_NAM8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12613">
        <property type="entry name" value="RRM2_NGR1_NAM8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12346">
        <property type="entry name" value="RRM3_NGR1_NAM8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000065">
        <property type="entry name" value="mRNA binding post-transcriptional regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000227">
        <property type="entry name" value="mRNA binding post-transcriptional regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000159">
        <property type="entry name" value="tRNA selenocysteine 1-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF10">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="90"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="183"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="322"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="391"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="437"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI10269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="453" mass="48695" checksum="DD7FB4B54985A74D" modified="2018-11-07" version="1">MSARQSGTFIHSLDSQIPRRGVLVILRAFQLLYHDPSEPQATRASTVRLISTQAISCNRAKMSYPNGTPPATDMSTVPPPPVGGQDQPKTTLWMGELEPWMDENFIKGVFLSAAGETVNVKVIRDKNSGNAGYCFVEFPSPEAASKALGLNGTAVPNSSRQFKLNWASGGGLVDRRDDRGPEYSIFVGDLGPEVNEYVLVSLFQARFPSCKSAKIMTDAMSGQSRGYGFVRFSDENDQQRALVEMQGVYCGNRPMRISTATPKNRQVCGNHGFGGHGHHGGPMMGGNAGMPQQQMWGGMQGFAYGGYNPATQMNQFTDPNNTTVFVGGLSGYVTEDELRSFFQGFGEITYVKIPPGKGCGFVQFVHRHAAEMAINQMQGYPIGNSRVRLSWGRSQNNSGVGTPYRPAPPPPHYMSMPSHGPGPYGPQHFGAPAPGLQGPPGPPGPPGPGGPPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7M2</accession>
    <name>A0A367L7M2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_4358</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7M2"/>
    <dbReference type="STRING" id="1330021.A0A367L7M2"/>
    <dbReference type="OrthoDB" id="9984533at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI10411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="745" mass="83804" checksum="1BECECC3314197F0" modified="2018-11-07" version="1">MDQVMDLVLDQDIDMDQGHLNIALIPAEFKFGEVDCALCGVPIIHQPLEERAPDLQDFALEKAEQTRWLRIARLIGNHPTSKQPLNARVSHPAYDSGNGNFMVAQGQTVKTYHRREGHPFVVPFHNDCMALLRHYLDETCVELEIDIEVLFDAVNHLSVDDNSSRTWKSLGIPYVGVGLLGMVDPFMPGAEHLAMSPIEIPELKSYYENLPRLSLARPDKVAAGNDIFSRLDHGIMANICRYLETNDIAKWRSASRSAARLDLDNDFWQTRVGEDMPWLFDFPDEAFPDTDWAEVYSDLSKASQLTRVDKMLGLANRRRIWEKQGPFFHAAYKFADNCKNYWMRELARYVGNFEVKQSLPLSFPPPLKTAIYLPTLLCEDLQDLDDAEPYINLSWTVSGTLAGIDVMKNGRMETLDHRFGEDHVGSERMMPFDQRISIPLDDWVTGLVMYCSTQPLDADLHDATCAVENIPDDKRDELLAADAEDQIGFYSFSRRVVGIEIQFAHQAAFLAGFRTDDVKLVHADPGRFVVGFRIERQTCSAAVTRVGLVMAPITPGMPGIQRVAPDDYWRDHKVPLDQLTLTRVPPAPLRLCEGLGWVTRAAKSRPCEVLVLGETNWELSHLTSISVDDNLDGIRADYSNGPPRSIGWVRDERRIFDIDGQGGERIIALFLIHDPELGSWRFQVNTSRQRQLVIDQGAAGPMVRLPLWSGLGGMNLVGGIYATWLSGHGHKLAGVGCLTTDDRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L835</accession>
    <name>A0A367L835_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_4240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L835"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI10588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="210" mass="23448" checksum="F7AD9A6822B7C31E" modified="2018-11-07" version="1" fragment="single">EGIHAQSPIGIVIAARELGKSDFLSIGHDFSMRKNVGKKWVCLLKSVGKVESNEVFCGAVEEEEGGEKLVEMEMIMSNQGVDHVIEKKKTNHVIVVLSDEVEADNKLEVGTSKGDLEEDFNVMDQPDDLTLRVDRLQRADRCNGCLVPRSIGCYDRYRYSAPIAVTIAVTSRFGRYDRYSPTVTQGVVAGLRPNWYNLFQVALQAYFLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L859</accession>
    <name>A0A367L859_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L859"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="71" mass="7199" checksum="8441F58BC51A5B4E" modified="2018-11-07" version="1">MPNIRGLRGASRGSPSRTPLGPGYACPYPGCARSSPARANSDKELANNDDDNYEPSPGAGGPYGGHGLGDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8D4</accession>
    <name>A0A367L8D4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5385</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8D4"/>
    <dbReference type="STRING" id="1330021.A0A367L8D4"/>
    <dbReference type="OrthoDB" id="9991317at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039340">
        <property type="entry name" value="Tfc4/TFIIIC-102/Sfc4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23082:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23082">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIIC TFIIIC , POLYPEPTIDE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="894" mass="101237" checksum="CB748022EEA461E2" modified="2018-11-07" version="1">MSHTENTLFRLSDHEGSEVDSDLEELRDDIAKLDESVRNFLASHHGLEATSGSARGGSRARGTRGPRKAAKPRGDITARLSKVNQAFLNGDYDQALDLATEVIRINAETHQAWTTLASIFRERGEPSRALSAMVYAAHLRPKDISGWLECASFALDFDESRDQAVDSLDTARLCYSAALRIDPAHIDARLGKAAVCHRQGHYAAAITEYKSILKRQPHDLEVVRKLAEACLDSRNTSAAVPSAVEAYKQFFALVTRRWPPLQEDSLWHDIGIFVDLLASINQYEEAIYELKSRSRWLVGRSSDLFWDEWKDDDREWDLDELRRMPVNSYSSLYAKSSLHGNALPQDLRIRLATYRLKLGHVSEALKHLHLMGWDDTRRNEFVEEFPFLAYDLAFELHRHGQQPLAIQFLQLLRNFLGDSDPSLLLHLGRSYLASGEQSSAEECLLAAIEADQDSIDARIELANIYEKAREDEEALILAAEAMALQEARAHVTHSFISGSDDATRPGVGLSRRRQCRVLSNNAVSAARASYESVVPRRYRPKRLTDTNKRLQDEQARVAKLSKHYETVRDLKQQIVAGREDLIPAWMATSKELVDDFRSLRRFYSWDKYLHFLGSGRYASTCAGEGSPSELTEMYERLSRCVAPQSDQPGRGLGYAGLSAHRGISFDDWLDLFLDYAIGLALMHRQEEAYQICKAAKDSTVFQSPEYCFNIDVAWSGKFREHTNALCRGLIISVCAIYTNDEERCVTIARQLMRDGATTDSYRMFALLSRLTQSPIAWYTSGPAQKFVLRQIKAIDASHSHRRRHLPESNIDTCLLMLYVFIYASIDSSNPMINISLGLAYVHYGMKRQSANPWRTDLHSGTIVQSRTVISPAWDQRYQFEILREGIRDRPGGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8D6</accession>
    <name>A0A367L8D6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8D6"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="143" mass="15423" checksum="CF535D31855934E5" modified="2018-11-07" version="1" fragment="single">YRYFSGSARHSYTHTQGTRPEGLGGSRDAGPAAAGPRPPYVTEAVRYSGCGYGTATPYSGYGRTGRTGRTRPEGLGGSRDAGPAAAGPRPPYVTEARLYVTTIGRNVTEVGTAQQRRRRLRHGYAVQRLRPYGPYGPYKGRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8F5</accession>
    <name>A0A367L8F5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_5382</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8F5"/>
    <dbReference type="STRING" id="1330021.A0A367L8F5"/>
    <dbReference type="OrthoDB" id="996720at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1730">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002673">
        <property type="entry name" value="Ribosomal_eL29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12884">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12884:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01779">
        <property type="entry name" value="Ribosomal_L29e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="39"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="82"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI10694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="120" mass="13580" checksum="15B46EB12700A32C" modified="2018-11-07" version="1" fragment="single">DNPHLSSFCKHCRAEYSHHILLNFTCITKAVNLQLASTTMAKSKNSSQHNQSRKAHRNGSVTVTQNNNTPLIYYSIKKPKTSKYPSLKGTDPKFRRNHRHALHGNAKALKEAKDGKRETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L975</accession>
    <name>A0A367L975_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">rRNA biogenesis protein RRP5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Ribosomal RNA-processing protein 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_5290</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the biogenesis of rRNA. Required for the formation of 18S and 5.8S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367L975"/>
    <dbReference type="OrthoDB" id="412781at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05702">
        <property type="entry name" value="S1_Rrp5_repeat_hs11_sc8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05703">
        <property type="entry name" value="S1_Rrp5_repeat_hs12_sc9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05693">
        <property type="entry name" value="S1_Rrp5_repeat_hs1_sc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05697">
        <property type="entry name" value="S1_Rrp5_repeat_hs5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04461">
        <property type="entry name" value="S1_Rrp5_repeat_hs8_sc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000103">
        <property type="entry name" value="protein RRP5 homolog"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000155">
        <property type="entry name" value="rRNA biogenesis protein RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000159">
        <property type="entry name" value="rRNA biogenesis protein rrp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000196">
        <property type="entry name" value="rRNA biogenesis protein RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045209">
        <property type="entry name" value="Rrp5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057302">
        <property type="entry name" value="Rrp5_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048058">
        <property type="entry name" value="Rrp5_S1_rpt_hs11_sc8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048059">
        <property type="entry name" value="Rrp5_S1_rpt_hs1_sc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 11 PRE-RRNA PROCESSING PROTEIN RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270:SF10">
        <property type="entry name" value="PROTEIN RRP5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23459">
        <property type="entry name" value="S1_RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="126"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="519"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="613"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="701"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="797"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="891"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="1000"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="1087"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="1181"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="11">
        <location>
            <begin position="1270"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="77"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1342"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1381"/>
            <end position="1464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1345"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1383"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1422"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1448"/>
            <end position="1461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00055575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00073619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00076674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI10969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1757" mass="191783" checksum="946E8D11BF159163" modified="2018-11-07" version="1">MSNLKRKTAPGGPPPTSSTKKAKNNTSDHEARPKAPVVSLLRNEEPMFPRGGGSVLTPLEKKKIHLEAKADALHDEEFNTAADGDSNKKRRRSLPHLDKTKAVGSKVAEEPGVKVESLNFKKLVKGSLVLAQVSRIDSLNLQLSLPYNLSGTVSIVAVSDQLTSRLDKAARENDSSDDESADDIKLKSIFAPGQYLRAYVVSTAQESLSGKPRRKIELSLRPAEANSGMNGDDVVPCSTVMASVVSVEDRGCVMDLGIPGLRAFLPTDKIDSSINHQRLQPGAVFLCRVSAKVSDGTVAQLSLLQGELARVGRVPSEATTINTYLPGTPATVIVSSVDRRGIVGKVMGHLDVTADVIHSGAGPDGVDLESKYKVGAKVKARVICNFPHAKDPKLGISLLPHVTGLTLKRPVSEDAADKLPTDVLPVSSLAEKCVVRHVEAEIGLFVDTGLPDLPGFVHISRVKDGKVDALYEGSGPYQLQSVHKGRVVGYSELDGLFHLSFQKSILEQPYIRVEDVPIGAVVTGDIDKVLVNEHGVSGLMVKIADGVSGFVAERHFADVRLQHPEKKFREGVKVKARVLSVNPSTRRMRLTLKKTLVNSEAPVATSLDQVSVGMHMPGIIVKLQHNGAQMQFYGSVRGFLPVSEMSEAYIRDPADHFSVGQVVGVHVVNVDAEQNKLIVSCKDPSAFGLDKQNAIKSLALGELVSAKVTEKTEDLVLVELEGSQLKAILPVGHLSDKSPTKNSSSFKRISAGQTLSGLMVVDKHEQRRAIILTQKPSLVRAFKDNKLPSNFEDVSIGDRLHGFVRDITPTAVYIQFCGGLYALLPKSRLSKEAQSQPSFGLHKHESIEVKVLSLLPELRRILVAPALAADEAALEQQKNKSGAPDDGLTYGSKATVRITSIKRTQLNVQLVGRETQGRIDVSQVFDGWDDIVDPKKPLGKFHRNQELAVKIIGVHNSKDFRFLPLSHRSTHSVLELTAKTGDVEGAATPTLLTLESLKVGESHVAFVNNATPNFLWVNLSPSLRGRISAKEASYDLAQVSDLESNFPVGSALKVTVKSVDVASKHLDLSARSQGSSGAVTWDGLETNMVMPAQVCQVSERQVLVKLSDSVSGPVELPDLADDYGEANAFSHRRGDMVRVSIVEVKAGSQVLRLSMRPSRILSSTMAVVDKEISHVSQLAAGDLVRGFITNMSDKGVFVHLGGQVTAIVMIRNLSDDFLKEWRDHFRLDQLVKGRVVSVDAAEGHVELSLRASAVDENYTPPLTWKDIRSGQVVTGKVRKVEDYGAFVVIDNSVNVSGLCHRSQMADKPVRDATKLYKEGDVVKAKVLDVDSQKQRISFGLNPSLFEDEDSDMVDASDSDADVGGAAAEDMDDVVFKLQKSDDEAAEDEAEEEEEANDGEGEMTNEMGGLGAGKKMSWAADPFHSDSESDEEAGPKENKRPGQRKKKEKASVEVDRTGELDAHGPQTASDYERLLLGQADSSALWIAYMAFQMQVSELPKAREVAERAIKTINAREEREKLNVWVAYLNLEVAYGSKKSVDEVFGRACEYCDGLEMHERLASIYIQSEKLKEADELLETMVKKYGAQSAKVWTNYAHFLHVTLGQPTRARALLPRATQQLDKRHYLQTISRFAALEFRSPKGEAERGRTMFEGLLATWPKKGDLWSQLVDLEMSVVAKASAAKGEKKAAEAAVREVFERRVRVGGLKPLQAERWFRRWTAWEEEAVDGGERAKEGVMAKAREWTVAYKARREGGGEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9H9</accession>
    <name>A0A367L9H9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">cystathionine gamma-synthase</fullName>
            <ecNumber evidence="10">2.5.1.48</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">O-succinylhomoserine (thiol)-lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_7460</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of L-cystathionine from O-succinyl-L-homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2-oxobutanoate, succinate and ammonia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-succinyl-L-homoserine + L-cysteine = L,L-cystathionine + succinate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20397"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57661"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="EC" id="2.5.1.48"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-cystathionine from O-succinyl-L-homoserine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the trans-sulfuration enzymes family. MET7 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.48" evidence="10"/>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9H9"/>
    <dbReference type="STRING" id="1330021.A0A367L9H9"/>
    <dbReference type="OrthoDB" id="10047078at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003962">
        <property type="term" value="F:cystathionine gamma-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000111">
        <property type="entry name" value="Cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000063">
        <property type="entry name" value="Probable cystathionine gamma-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051750">
        <property type="entry name" value="Trans-sulfuration_enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699:SF1">
        <property type="entry name" value="CYSTATHIONINE GAMMA-SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="4 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00051441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00058439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00060510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00066530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00083849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI11066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="595" mass="67514" checksum="ADD00BFB879A3C54" modified="2018-11-07" version="1">MPRFILGQSIPPDTAHAISVSLPTWKSNVGYEEGQEWVISKLETGYPRFHIHESIKALTIHIRLYYGRPGQQAMLFSTLGSATRCIAFIRRYAMPDMKSCLNILDLVVDVSKSSSALLRWLCPTLHVAFFDEGAYGLAKQYWQHTGDGVSSRRAEFYFDLLRNGILIPRQAADHQSQFRLQKGPRRYMSKLTYTTSVSPDVKSFPYDQTGDHDECCRFLEERFGRNLDFGLVEQANLAIRRRIAGFLTHDSSRNEFRLASVNPSFQAQQDVKEDDVFLFPNGMNAIFNVHRTLLSALGQFPSVSFGFPYVDTLKILQKFGPGCMFLGRGSSDDLDELESLLRSGERYLALFCEFPGNPLLTCPDLQRIRSLADRFDFSVIVDETIGTFANINVLPLADIVVSSLTKIFSGDSNVMGGSVIFNPHGRHYALLKRVMVEEVYEDAYWPGDIIFMERNSRDFVPRVRRINVNAETICHVLRESSLVKRLYYPMFNPSRDYYDARRLPQGGYGGLVSVIFHYRRQAEAFFDAINTAKGPSLGTNFTICSPYVILAHYQELAWAAEFGVQSDLVRISVGLEDTESLKSIFKTALHTAEQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LA90</accession>
    <name>A0A367LA90_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_7606</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LA90"/>
    <dbReference type="STRING" id="1330021.A0A367LA90"/>
    <dbReference type="OrthoDB" id="409586at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF12">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="51"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="155"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="260"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI11347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="38310" checksum="56BD5F8956F5B526" modified="2018-11-07" version="1">MEDGRKSFTRLTNIIYTCRAQYKQMEKSTTSDLQPSSGGGGGAAAAAHQTTKDLFSGAMGGIAQVLIGQPFDIVKVRLQTTNRYTGALDAATSIYKSEGPLAFYKGTLTPLIGIGACVSLQFGAFHAARRWFEARDNNDHRNPEAAFVNEQQQQLKLSNIFLSGAFAGVVNASLSSPIEHIRIRLQSQPHDRQSRLYSGPLDCARKIAVEAGGWLPGLYKGTCVTLLREATAYGAWFATFEALMTADVNRNRRTDRAQVPAWKVAFYGGLAGEALWLVSYPFDVIKSKMQTDGFGVTCRYPTMRSCFVHTWQQGGFAAFWKGIWPTLFRAMPVSAGTFAVVEMTRRAIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAK1</accession>
    <name>A0A367LAK1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7509</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAK1"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI11457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="160" mass="17947" checksum="8D820C6532A6BD56" modified="2018-11-07" version="1">MGPDGKRRSQDSLGTAGFPDDHSLFNRSVLVFPVDEATYLVVYKPQQTDMLVTVASDISNAAPQRSFPSSDPASSVAFPSSQLRYLALIMVQVDHWLHKQVGDMRHTAAYGAFKCWQSASWMQKGGKYFQVALYLNTSQKLRVITERMTAEILLFFFSPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAM1</accession>
    <name>A0A367LAM1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7124</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAM1"/>
    <dbReference type="STRING" id="1330021.A0A367LAM1"/>
    <dbReference type="OrthoDB" id="5235778at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="569"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="605"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="761" mass="82749" checksum="12B795E11109A588" modified="2018-11-07" version="1">MSSCTGIIMEEPKLVDVAMKTTMTTTTSKTTAEKPEQQEQQPDDQQSSPTSPKLLTVLDPPPTRDADADEEQDKPPAAQQPQAPTPPAELELSREAKKESPPAARLSPPPFTGPDHDDAEVESELSEPGSNVASPPAESMMELEDEIVVGDRPNERTKTSPPRGNPSAEPDQEMQDVRDELSVSSHYPKRKRTSLYSDLSETKIEISQAQPANDSRLPALARDLKSKSTRQSLAAANVKGVLLGHWRDSAVTDESMKHAVYGFIDSRDRLRTRIQPQTKGGKSLVQDHPLPPGAGATWVTFDRVVLSPHLANLDQLQIKEYTRIRLTAASDETDQERKAAEAEAAKEAVSRVKDVNAGSETPDATSRPDAKRRKVSGGYAAGTATPSDSSVVDAVRSQTPPHPIASNQTRFSIDPLPGTRPTRILLGFWRPSSEVDPKDRHAVYGILGQNDMFRVKVVRETRDGRFVDGNFPSGAGALWIPYEEVEFDQHLARLSRQEIKEFCRIRQFQIDHGETEADRADNETKAVQEAQTRAAVLLKQPSASAAAAAAAAAVATAAAAAAALTATASNPAASSDDMPDRPSVKPAHELRQSRRIEPRPDSGRNLRQTPNEGGTRSTQRLQGSDAVERTSALARREISRVEAIQGRVDRLALSRERAVAAATDAASAAAAAAAAESPAANGRTTLFHESEDMQRLNKVWARQESLRMKAGAEDVKIYDGVKYERKSTGPFMGKLVSQGAIINIEGEDYVEYRVLTKPSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAT7</accession>
    <name>A0A367LAT7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_7488</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAT7"/>
    <dbReference type="STRING" id="1330021.A0A367LAT7"/>
    <dbReference type="OrthoDB" id="1049195at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000145">
        <property type="entry name" value="Putative RNP domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000280">
        <property type="entry name" value="RNA-binding domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF3">
        <property type="entry name" value="FI21236P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="208"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="374"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI11524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="474" mass="50961" checksum="042C68FBF8101B4F" modified="2018-11-07" version="1">MSAHVQDPAADMSPQRERSRSPRRRSRSPGRQPRRRSYSPRSRSNSRDDYRRGRDRSPMTGSGAPGGGTGASFGSQPSHRSYEERAVAREQMMNNIRETSQQDRRVYVGNLSYDVKWHHLKDFMRQAGEVLFADVLLLPNGMSKAVAQLSNQNLMGRLVYVREATQDREAEPRFISANSGNRGGFGGGMSPGFNPGYGGPPGGGGGGRQIYVNNLPFNTGWQDLKDLFRQATRIGGVIRADVHVGPDGRPKGSGIVVFESPDDARNAIQQFNGYDWQGRLLEVREDRYAGAGMGFPPRGGYGGGMRGGYGGAGGGGGGGSFGRGGFGGSRGGFSFSGRGGFAGGPGGGFDSAPATTVPPNPFTDNATAGTERGQTIYVRNLPWSTSNDDLVELFTTIGKVEQAEIQYEPSGRSRGSGVVRFDTPETAETAIAKFQGYQYGGRPLNLSYVKYLNQAAVDNMETDPHVGLTQDQIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAX3</accession>
    <name>A0A367LAX3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glutathione synthetase</fullName>
            <shortName evidence="10">GSH-S</shortName>
            <ecNumber evidence="10">6.3.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L249_7255</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13557"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58173"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10 12">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the eukaryotic GSH synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.3" evidence="10"/>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAX3"/>
    <dbReference type="STRING" id="1330021.A0A367LAX3"/>
    <dbReference type="OrthoDB" id="2020073at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00210"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043295">
        <property type="term" value="F:glutathione binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004363">
        <property type="term" value="F:glutathione synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.50:FF:000002">
        <property type="entry name" value="Glutathione synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1760:FF:000001">
        <property type="entry name" value="Glutathione synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1760">
        <property type="entry name" value="Glutathione synthase, substrate-binding domain superfamily, eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1080.10">
        <property type="entry name" value="Glutathione Synthetase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005615">
        <property type="entry name" value="Glutathione_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014042">
        <property type="entry name" value="Glutathione_synthase_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014709">
        <property type="entry name" value="Glutathione_synthase_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014049">
        <property type="entry name" value="Glutathione_synthase_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037013">
        <property type="entry name" value="GSH-S_sub-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004887">
        <property type="entry name" value="GSH_synth_subst-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01986">
        <property type="entry name" value="glut_syn_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11130:SF0">
        <property type="entry name" value="GLUTATHIONE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03917">
        <property type="entry name" value="GSH_synth_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03199">
        <property type="entry name" value="GSH_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001558">
        <property type="entry name" value="GSHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="4 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="9 10 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutathione synthase substrate-binding" evidence="14">
        <location>
            <begin position="214"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
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        <location>
            <position position="146"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
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        <location>
            <begin position="148"/>
            <end position="151"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
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        <location>
            <begin position="224"/>
            <end position="226"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
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            <position position="230"/>
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        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
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        <location>
            <begin position="289"/>
            <end position="292"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
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        <location>
            <begin position="395"/>
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        <ligand>
            <name>ATP</name>
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        </ligand>
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        <location>
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        <ligand>
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        </ligand>
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        <ligand>
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        <ligand>
            <name>ATP</name>
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            <position position="483"/>
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        <ligand>
            <name>ATP</name>
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        <location>
            <position position="489"/>
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        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
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    <feature type="binding site" evidence="13">
        <location>
            <begin position="492"/>
            <end position="493"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001558-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCI11566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="505" mass="55062" checksum="15A234C784D4E5B0" modified="2018-11-07" version="1">MAPPNLPPSLSDTELDNLVRTVDDWSIANGLVVRPPPGLVATETAAVCAPVTLFPSPFPRGCFEQANALQKTYNELYASVSRNEDFLADMVKQVMDGDEFILKLWKLHLRVKQEGYTQPLSLGLFRSDYMVHQDGSTMHAKQVEFNTIAASFGGLAHRTSLLHEYLAGSEYPLLRKPIATGSLALPENDTLRGLAAGIREAYRAYSTSELGHATCVLFIVQDGERNVFDQRHLEYAVLGASSPAIPLFRLAFANIMAHTSIADTPRRQLLYRSPCNPSAVWEVAVVYLRAGYSPGDYPDQAAWEARYQLERSHAIKCPTVLTQLAGTKKVQQVLATPGSPSAPSVLARFIGDDPAATAQLQNTFTNIFPMDTSAEGLEARRRALDPDLCKSYVLKPQREGGGNNTYRGAIPGFLRSVPEEHWPSFILMELITPPPVSNLILRNGRVEKGEVICELGVYGACLWNQLSGELAMNEGAGYLLRTKGSASEEGGVAAGFGCMDSCALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBN3</accession>
    <name>A0A367LBN3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_7513</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBN3"/>
    <dbReference type="STRING" id="1330021.A0A367LBN3"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="512"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI11825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="532" mass="59510" checksum="F449EB833360A2BA" modified="2018-11-07" version="1">MSILLRSLSAAALIAFLSLIVSRSWRRKGVVLRLPPGPKPLPLVGNIRDLPPKGVPEFQHWLAHKDIYGPVSSVTVLGQTIVIINNRQAATYLLEHQWLKTSGRPQTTFVDMCGMSHFIACLSYVDDLRRRRKLMLQMLGTERRTEQYHDAMENSSKCFLNWALTSPEKIFKHLENFTGAAILNATYGYSIGTDQEDPLVRLGRSLMIKFSLAVAPGAWPVDFIPALRNLPDGLPGTESNATARRWKKTSQRMVEVPYLFVRNQMKTGCYRPSITSRLLELHGQKELNSQEEDDIKLAAAAQFGGASETTAASLKGFLLAMIRFPDVQRKAQNEIDRVVGTERLPRCQDRANLPYVVNLVKEIFRWSPVAALGLPHTATEDITYGGHLIPKGAILLPNLWWFTHNPEVYSDADSFNPDRYSESLCEPDPTVAFGFGRRACPGRFFAEASVFTIVSQFLSVFNISEAVDQGFGIKAQPQLKALPGIITFPEDFAYSITPRDDTKDKFVQNMMADQPVQSSDASSLDDAVFDRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBS4</accession>
    <name>A0A367LBS4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000009">
        <property type="protein sequence ID" value="RCI11879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBS4"/>
    <dbReference type="OrthoDB" id="4931002at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="8"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="160" mass="18622" checksum="EB1EFE1A4BB5E592" modified="2018-11-07" version="1">MLRYSFALRSRSGLQRQQQQQQQQRQQTQKDHLITGCQEGGRTRGPRQQTSRPSSFLRQGIGFYEKLRRHEARRPKTKDTIDWLEKHAFFYRKVGPGPGPDESTEHSYGLFQALPKEIQVQLYDKLERPSSSPYGILFSTAYFLTQIQLEDNSYSGFSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LC59</accession>
    <name>A0A367LC59_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_0848</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI11991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LC59"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI11991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="47" mass="5328" checksum="CCFBCFB129FFDD14" modified="2018-11-07" version="1">MLLESLSSLITSLPLLSTPSRSFCLRRLYLIGRSTWLFKLTRNAGTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LC90</accession>
    <name>A0A367LC90_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_0530</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LC90"/>
    <dbReference type="STRING" id="1330021.A0A367LC90"/>
    <dbReference type="OrthoDB" id="566138at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018555">
        <property type="entry name" value="C630.06c-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678:SF34">
        <property type="entry name" value="OS04G0183300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09428">
        <property type="entry name" value="DUF2011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016834010" description="Thioredoxin domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="4">
        <location>
            <begin position="50"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="839"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="696"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="715"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="733"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="753"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI12040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="958" mass="102953" checksum="F6C261377CE6CE07" modified="2018-11-07" version="1">MKPLLRLLLALAPLASTTVSELAPKFPPLLDSTLDDLQAGLEAGHFTSVDLVRAYVARIEQVNDQLRAVLEINPEAEAIAKVLDLERRNGQRRGPLHGIPVLVKDNMATHDAMNTTGGSFALLGATVDEDSTVVSKLRRAGAIILGKSNMSDWAGARSPTCPEGWSPRGGQTVGAYFAGQNPQGSSSGSAVATSIGLAWAALGTETTTSITGPAHANNIVAIKPTIGLTSRHLVIPLSRRQDSVGSMARTVKDAAALLSAIAGPDANDNYTSAIPFKQLASYVEACRPGALQGKRIGVVRGFEQLKPQPDQTVLLSLASFNSSLDVLTEAGAILVDGISLPDLPEYSEFPLRGLCILSDMRDRLPEDYLRHLKKNPSGISSLRDLRRSVLETKSEGDCDTLLWDVALSMSPGDKFVHDMAGRGLSSTVMRTHSLDALIMPPLYAALVASVSGLPVVTVPLGATPSDTAIVANPDGGGTNIMGPNHPFGISFVGDAFKDANTRHGSTPNTAANRLMFPYNRADPLLSPFDCISTMFELPEAKRVRREDLEASDGLSQISDDDTDDAVRASLQAQLEKSLGFESCDVKSTTDKGSTLPVSRALNDEEKNDAGEFEFRLFSTAGSVPKVVLDAGDEAPGEGDIVAKRPPTHYLASIPEKLRQEYEVSSVSGEDVLARSRCRSWGLELPWKVITVTTFSKARPDGGSTTESAGNTEPAKRKRPGKKMRIAMRKRERAARERHDLEVKQEVEKAEHLKNKKTKLNRAKKLRRRAKEKDKKMAAVNAAPGSDAELGSLEDGPGWRSVKDGTDMRIAIPRTFVRRLSSLPNSSKMGQNSPLRNISSEEEFTSLLQKTTYVVVDFTADSVAPIFESLAAKYSVPNVLAFAKVNVDNVGTVAAKYSITAMPTFLFFKEAKQVAVNGQAMIRGADATALTSAAEKIVGFDRLRESLGLESAFSSRGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCA7</accession>
    <name>A0A367LCA7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCA7"/>
    <dbReference type="STRING" id="1330021.A0A367LCA7"/>
    <dbReference type="OrthoDB" id="5151897at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF467">
        <property type="entry name" value="INTEGRASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="425"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="545" mass="60851" checksum="FC94D930EE372728" modified="2018-11-07" version="1">MGEDEEGEKIWSVYINICSKFMQWLTLGSNLAKHCSERGFCVVVRNGDLGKMKQLGIVKLHLKHIYLPYNKTKQNGNPRLGCQTTTTDGDEPDETVQGGLGLLQARMFDTAQATSWGHDPLPIWAREAFLRSNCLPSLMLLALIFLLVTETGGGSQTRGDDLPINTITSLYDIIQLADIVQVPNVRPLRHRHHRDSCSSRAMPILVFEEKSWSRRGAAVASTCLGSSSLDKARLQMNILIARREEAVRVMLSKSSDEMVNIKDKHSLWMAALPEPACASAVALATFLSLGINLGGQPDKGKDLCLGMHSDASFADDKASRCSTAGYIIFFSRGPIPWRWKKQNLVITLSTKAEFIALKPAALVTIWIWSIVKDVGYEQKCPLLLYTDSQNALLAVLNPLNKTRTRHVDMCYKWIQQRHQQGFFRAASVILIGYELLTLSLFLSLSRAVYGVRLKAGIRRRLLVIFFLRLLRCNLPNLVRRSPDRDTTLLSPGTKNFASWNATITLCLMDGGLEDYVLYPDARAQGPTPAHFVCTSIIRISTFRAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCE9</accession>
    <name>A0A367LCE9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0884</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCE9"/>
    <dbReference type="OrthoDB" id="3540210at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="565"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="695" mass="76944" checksum="A51958E8ABB9D319" modified="2018-11-07" version="1">MSDSSAQRRVHLGSWTDWSRGPVMGVTLTLDRKQGALLIAFTAFFVGIVASCFWRILVFFVYRLYSTAAPRDALHHQRQALLRNSVTAPSTLWAFSQLCWTWRRAGASRLRRTLPVIVCALVSIALFAVASGFSSQIASGTGSAALLDGSHCGYVQGATQASRLDDLGVLFPYGVRRLTESANYAQQCYSARTGAGLLSCGTFVLRSLPYTSNHQASCPFRGGICRSNTSNLMLDTGYLDSHEHLGVNSSPDLRIRFRTMLHCAPLETEGYSTDIRNPSRNYTRYFYGRRTHESSPDRDGNYTLQVRALSDQYGWYYRNADNQDAGYSPSIQNYVAFVRDGRFSANGSEFEPIPQLSRADGDIMIFFLVGNGATFMRPTPDLWYRGTASGKNVSVDHSADKLSLETYEPEEAASPLGCVQQHQFCDSSGRCGPLAGYLDALQGAHILFNSTALGQYRPDEKPDTLFGSFRRALGQSLGTIDFMVSSFQSNSLLSQQVSSSGLRGPLPDNQWQMDVNYWWDTMLATMQASFVQLAAWTADRELEPYVTHLNSSYICRNQKILTSEYTAFSVFGLCFTYSLGCVIILISFGLEPTLDFLGRRRKPQGYTSLERQSYQLLQLQRAAYQGIGSGIWQGFTGAVPTTKGVEVLADLASRYGGSEKMTGHSAVDSDDTRINLDEDDVVVVSPTIPRRHSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCQ5</accession>
    <name>A0A367LCQ5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0501</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCQ5"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="193" mass="21254" checksum="3175451F69A861C9" modified="2018-11-07" version="1" fragment="single">MKVRIEMVSRPVQQGEGISSFDPSLYRVDLKRRPADQRFGRARAALSLQRGSSHLQGGGPDQSKRWPSIHPQSYSRGVDQYPRCKAFVTYAVSRESSFSLWKGEKKRGLMVDDTPAIGRPGPGQKPLHGDGEGERGGLGEKPIYVSVTSRMKPNRDGAQTMRTARTPPVSTFSFECAQGPGEKYSTLQKASTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCR7</accession>
    <name>A0A367LCR7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_1353</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCR7"/>
    <dbReference type="STRING" id="1330021.A0A367LCR7"/>
    <dbReference type="OrthoDB" id="10253125at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000002">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000004">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005711">
        <property type="entry name" value="Ribosomal_uS5_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01020">
        <property type="entry name" value="uS5_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718:SF4">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="RIBOSOMAL S SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="9">
        <location>
            <begin position="79"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI12216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="275" mass="29720" checksum="E7FF58B0B1CA45F8" modified="2018-11-07" version="1">MADRGGRGGGFGARGGDRGRGRGRGRGRRGGKSEEKEWQPVTKLGRLVKAGKINSMEEIYLHSLPIKEYQIVDNFLPKLKDEVMKIKPVQKQTRAGQRTRFKAVVIIGDSEGHVGLGIKTSKEAVVIIGDSEGHVGLGIKTSKEVATAIRAAIIIAKLSVIPVRRGYWGNNLGTPHSLPCKQSGKCGSVTVRLIPAPRGTGLVASPAVKRFLQLAGVEDAYTSSAGSTKTLENTLKATFVAVSNTYGFLTPNLWKETKLLRSPLEEFADTLNKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCU9</accession>
    <name>A0A367LCU9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histidine kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_0259</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LCU9"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050956">
        <property type="entry name" value="2C_system_His_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058846">
        <property type="entry name" value="PAS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719:SF30">
        <property type="entry name" value="TWO-COMPONENT SYSTEM RESPONSE REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26131">
        <property type="entry name" value="PAS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="1014"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="1338"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="120"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="192"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="1398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI12237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1481" mass="164748" checksum="4C5B2B96021DC72D" modified="2018-11-07" version="1">MQPPGNGAASRTRPPSFAPTKSTSPIPAVTNPTRPTAPTATPSAPPPPIAAAGSAPPYDEAIPEHRRRRQQSHRRHPGPPAPPWASVNRPDLSSSAQSSSSSDAALTSHYRALYYRPHQPQHHSAFGRSSRTRSQLAKRQLPRHDDTGMHQAPAKKLRTLASPPRRFEMLSSSTIPSPSLHPPNPQVPHDGPFSPSPVFSPSSSRPLARSTNSLSSDMGMLSRSRDDAPSITTVKLPRASVCSSPAMTGSSLSSSLDLSLPKLSPDGRNLPASLQRVQNIGAIELVEHDDRPTFLVDTYTPPDANHPGLNILYYNTAMRSCPDLCASLAIDSGGHTSEDFDRFKTWVYCLNISDTSCSLMSTHQYGGTNWTATTLRQRFRFISTTITPRASLLDLSRRSSFESGPSVVESPLTQSMPITPEGDNPDLPDYFGNAASDGLGHERLPSFTNLVTEPDLEADRRHPDEFTNQVLQLQPTKSVFDWTRIPFSDSLPEHIKFVKSFDWASTPLGPLSEWSSDLRAMSNLIMGSPHPAAMYWGPELISIYNAAYIELAGQKHPSLMGKPYKEGWSEIWEEIAPIFKSAKECGQAIMKHDNQLFLNRHNFLEETFFSWAIVPLVGVEGEVVGLYNPAFEHTLRRINDRRMLTLRELGERTATATTVSGFWPQVQKGLEYNEHDVPFSLIYSIKEDVESEVSSLQSGSFMHSPQILLEGSPGVPEGHAAAPAYLDLRTAEEGFAPYMRQCIQGGGEPLVLSARDGTLPKHLLEGIEWRGFGDPCTTIVIFPVVPTTKEAATGFVVLGLNPRRPYDDNYKLFIHLLSRQLATSMASVVLVEEEIRRGQRAARLAALDRQELSMQLLLRTQEANESEYRFTRMAEFAPVGMFIADCHGRINYCNDMWWQISRHSRFDETKLAWMSSVRAEDRPSLEEAWQKLLDERVTISVEFRFNHSQQRGSNTIDTWALMSAYPEQNADGGLKSIFGCITDISSQKWAEKVQSERREEAVELKRQQENFIDITSHEMRNPLSAVLQCADQISNSIVKFSTHKDQGQLDTFLEACLDAANTINLCASHQKRIVDDILTLSKLDSNLLAVTPIDEQPVKAVQRALKMFESELQAHDIELEFNVDDSFERHGIEWAKLDPSRLRQVLINLMTNAIKFTQGRDKRRIIVSLSASKDISEVTSKGVLYFDRIDSQRTTGMDIENEAEWGSGERINFHCSVEDTGPGLAEEELKLLFQRFQQATPRTHVKYGGSGLGLFISRILTEMQGGQVGVTSVRGEGSKFNFYIQSRKCVDSASGYERTSTFKMGRKTQVAAAAASTTPGGVTASREVRDKAEQSLFDVLIVEDNIVNQKVLQRQLRSCGNNTFVANHGREALQTLERSRFWAGHEAEGVDISVILMDLEMPVMDGMTCARRIRELEKEGTIVKHIPIIAVTAYARPEQIEDAKAAGIDDVISKPFRIPELMPKIEELVGKWRNLAVPAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LD01</accession>
    <name>A0A367LD01_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Secondary metabolism regulator LAE1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_0277</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LD01"/>
    <dbReference type="STRING" id="1330021.A0A367LD01"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI12300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="36744" checksum="6AA8A546CC695FD0" modified="2018-11-07" version="1">MSPNTIPGQLPQPPQLLQGFWAHGRFYGGWRPRKYPFPIDSEELNRLDLFHKFFLVARKKALCANNLNLGRPAKILDLGTGTGIWAINVAEESQQMPEIMAVDLNRIQPPLIPRGMETLQFDIEDPSWDSLMWNCDLIHLRMLFGSIQTDLWLDIYSKALDHLAPGTGSLEHVEIDWVPRWESSGDLPENSAFKQWSDAFLKALDLFNRSARVSTHHTRHLMEQAGFCDFREQTVRCYVNPWSPDAWEQETARWFNLGLRHCLDAMSLMPMVERLGMTVEEVKDLCGRVNEENLKLRYHGYCMSPSSPIQAGRHGPAGRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LD90</accession>
    <name>A0A367LD90_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_1293</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(27)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60292"/>
            <dbReference type="Rhea" id="RHEA-COMP:15535"/>
            <dbReference type="Rhea" id="RHEA-COMP:15548"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.356"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LD90"/>
    <dbReference type="STRING" id="1330021.A0A367LD90"/>
    <dbReference type="OrthoDB" id="6141102at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140951">
        <property type="term" value="F:histone H3K27 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026489">
        <property type="entry name" value="CXC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045318">
        <property type="entry name" value="EZH1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048360">
        <property type="entry name" value="Ezh2_CXC_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040968">
        <property type="entry name" value="EZH2_MCSS_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040595">
        <property type="entry name" value="EZH2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041355">
        <property type="entry name" value="Pre-SET_CXC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45747">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE E(Z)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45747:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE E(Z)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21509">
        <property type="entry name" value="Ezh2-like__CXC_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18600">
        <property type="entry name" value="Ezh2_MCSS_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18601">
        <property type="entry name" value="EZH2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18264">
        <property type="entry name" value="preSET_CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51633">
        <property type="entry name" value="CXC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CXC" evidence="9">
        <location>
            <begin position="547"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="8">
        <location>
            <begin position="679"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="69"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="821"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="855"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="979"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1000"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1019"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1071"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1097"/>
            <end position="1106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1112"/>
            <end position="1124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI12389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1131" mass="125983" checksum="ACCA824D6C78B9D7" modified="2018-11-07" version="1">MRRNQSSIPLASSGPEAQASDPESLASWHRYEPSDCFRALAFTPWLMSPSSPSASSGTLQAAFDPDKAGALSMAPGLPRRSPSLGASDRNETVNLSDSRDEWTVPEVAEQLSRFRQEVRENHAQLVSYIIESSRSIERRVPHGADLFAAERSASVPEKKATTMRFKFKHFLKSKKEGKEENHVVTCIKTDKGRVPRYRFHHVDIKKNVLTPNTMLTFVPHLRDLESSEETKYNLWLKELEDIDLKSGFKPMNREEKQALTYQLERAATIAPYLGIWLDKLAIPGCDKQTLVRYMASRAPDDAALPLQKLETARSRRDSKNVASAEDNGGARMFEEAFTTVFKNRLPPAKQVNLRRVLLLEESPDGFVDSKPSAKDGTTTLREDDDELAENYLATYCLLGCLICFSHSCDHGEYDNKNMKRTFSMASCFRLSDALKRRRRGAINGATSVPLPCARGCYRWFESDRSMWTFSEHEEKPWSEEEEGVLRSVFATASHSKYKGDVVCLAAKFLSRSCRESHAKLKRLGVRLPEPPPLPESVRVKSLSWYDRRRKALLGDWPDHTISHEHQRRETLEPCCHDGPCVSRLCPCVDAGLLCDKFCGCTADDCAYKFTGCACHSQGKTCQQKQKDKPCICVQLNRECDPQLCGSCGAVERADPLNADDEQLQATGCQNCHLQRGVGKPLILGQSQLEGVGYGLFTAQDIAQDDFIIEYVGELITHDEGVRREARRGDVFDEESNLSYVFTLLENDGIWVDAAIYGNLSRYINHASEQDKRGCNITPRILYVNGEYRIKFTAMRDIRAGEELFFNYGENFPNLTKKLLDHKAGQQAGKSNKESRRASAGDQVARKAPNPVQKRGLPKAKPTKKRVAIDPYRFESTEAEVQPRRRQRRVGGQESLPGTLPTSNAAKKDPQPKEELDEGLTRLRKRTRSSSGCLEMKIAEPPKKKSKRGGARPGSGRPRKHPRPVPKPPVPLAAPEGEDGASAAAAGTTPGATVDAKVESIENDSGDVAEAEAKPTTVEPKAKPVEFEAKPVDSTTTPVEPKAKPAEQLQAKPVAARDEVITPKAVPPDVVMIEDTDDETTIDSDESPPQARLPEMTEQADDDEDQDVVVRNRNGRAARNRRPPAKLREGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDA7</accession>
    <name>A0A367LDA7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_1124</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDA7"/>
    <dbReference type="STRING" id="1330021.A0A367LDA7"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016578754" evidence="8">
        <location>
            <begin position="21"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="9">
        <location>
            <begin position="46"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="10">
        <location>
            <begin position="171"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="6">
        <location>
            <begin position="171"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="355"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="437"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="381"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="437"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="448"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI12400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="459" mass="51253" checksum="D50E581DD357EAF6" modified="2018-11-07" version="1">MLVRILGLLLLLALLQVVACEKDYYKVRLRTSTRASSKEQLSHNVGFFQVLDVSSKATDKELKSAYRKLSKKYHPDKNPGDESAHENFVQVADAYSILSDPEMRQVYDRYGHEGVKSRRQGGGGGADRQDPFDLFSRFFGGHGHFGASSHEPRGHNVEVRVEIALRDFYNGVDTEFHWEKQHICETCGGSGSADGHVDTCNVCGGRGVRIIKQQLAPGMFQQMQMRCDACGGRGQTIKHKCPACKGARVERKSTTVSLKAPRGVACDARVVFENEADQSPDWVAGDLLVILVEKTPSADDNPSSVDGNFFRRKGDDLYWTEVLSLREAWMGHWTRNLTHLDSHVVRLSRPRGSVVHPGHVETVPGEGMPIWRGEEQDDDSSSSSSSSSSSSSSSRPTTSYGNLYVTYEVVLPDQMEPAMEKDFWSLWEKWRKKKGVDLHKDSGRPDEPPFSPPPPRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDI0</accession>
    <name>A0A367LDI0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_0411</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDI0"/>
    <dbReference type="STRING" id="1330021.A0A367LDI0"/>
    <dbReference type="OrthoDB" id="10259133at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09251">
        <property type="entry name" value="AP-2_Mu2_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14836">
        <property type="entry name" value="AP2_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000002">
        <property type="entry name" value="AP-2 complex subunit mu, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043532">
        <property type="entry name" value="AP2_Mu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043512">
        <property type="entry name" value="Mu2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0168">Coated pit</keyword>
    <keyword evidence="2" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="7">
        <location>
            <begin position="180"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI12488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="458" mass="51485" checksum="CEA68D9EF8DA2A84" modified="2018-11-07" version="1" fragment="single">QSRVEGSLAHAIMISGVLVFNQKGENLIFRAFRNDCRPRLADVFRIQVISNAQVRSPILTLGSTTFSHVKHENIYLVAITKSNANAALVFEFLYRLIQLGKGYFGKFDEEAVKNNFVLVYELLDEIIDFGYPQNTETDTLKMYITTEGVKSEVKPQDTSKITMQATGALSWRKANVRYRKNEAFVDVIEDVNLLMSATGAVLRADVTGQIIMRAYLSGTPECKFGLNDRLLLDNDGLQSYPSGNRTGTKATKAAAGSVTLEDCQFHQCVKLGKFDSDRIISFVPPDGEFELMRYRATENVNLPFKVHAIVNEIGRTKVEYSIGVKANFGPKLFATNVVVRIPTPLNTAKITERCTLGKAKYEPSENNIVWKVGRFTGQSEYVLSAEAILTSMTNQRAWSRPPLSLSFSLLMFTSSGLLVRYLKVFEKSNYSSVKWVRYMTRAGSYEIRWDGDPIWLPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDR8</accession>
    <name>A0A367LDR8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_0338</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDR8"/>
    <dbReference type="STRING" id="1330021.A0A367LDR8"/>
    <dbReference type="OrthoDB" id="5204190at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="172"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="270"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="374"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="89"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="243"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="345"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI12569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="537" mass="57532" checksum="43E87FC025139BCB" modified="2018-11-07" version="1">MADSQPDIQSILAALASQRPPHSTAGQTPGAPPRPWLSNASLVDAAGWLPAASPFRRRPPYGGPAHSLPTPAASGNVDLSAIRPVTSGTMNFDDVGSKGFAPEKVGGDRQLVYGTDTRNNDRSYRRSRSRSPRAEYGRDYGRERSYSPPSRGRPFSPRGGNGRQRSPLRAVDDNSETIQIESSLVGLIIGRQGENLRRIETESKCRVQFLAATDGVPYRQCRVSGPRQRRAEVKAAINRIIDDSGMGALNRPPDKSRDQTRGGTASLRDGEDHMQIMVPDRTVGLIIGRGGETIRDLQERSGCHINIVGESKSVNGLRPVNLIGTVEAAARAKDFIMEIVDSDTRGDGPAVKKAPPTAGRAEAPPREVAGGGQDKVNDVIYVPSDAVGMIIGKGGETIRDMQNSTGCKINVAPSSGSGEAQREIGLIGTRDSIARAKQAIDEKVDAVRQKSGGGGRNRGQQPDMDRAAYAQNPSTNQAAGDSSDPYAQCEWWRPQRQSLTDPTILDGGYQNYVALWYQSLMYQQQQGGQGASAGGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDV9</accession>
    <name>A0A367LDV9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_0180</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDV9"/>
    <dbReference type="STRING" id="1330021.A0A367LDV9"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000003">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF10">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="254"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="286"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="309"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="338"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="10">
        <location>
            <begin position="33"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI12422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="472" mass="50236" checksum="9ED447D06B8425E8" modified="2018-11-07" version="1">MATAYNGTTGIADAGYSTKATNLNVFYDTGNLAFLTVSSVLVLLMIPGVGFFYSGLARRKSALQLVLLSMLSVAVIGFQWFFWGYSLTFSRTGNSFLGDLSQFGLMKTIGQPNGSALLPDILFCLYQGMFASITPALAIGAVADRGRILPALVFIFIWSTVVYDPIAYWTWNANGWLFKLPSYDFAGGGPVHISSGSCALAYSLMLGRRTGYSSNGGLPYRPHSVTNVVLGTVFLWVGWFGFNGGSALGMNIRAVMACYVSNLAASCAGITWVLLDYRLEGKWSTIGFCSGAISGLVAITPAAGFVTPWAAVIIGVCGALCCNFATKLKFVLGVDDALDIFAVHGVGGMVGNLLTGIFGTSSMASLDGNAYPPIGWVERHWIQLGYQAAGICAAFAWSFGLSCIILFLMNLVPGLSLRVSADDEVVGIDDCQLGEFAYDYVELTRHVADSVHASDRNGSSDGEKQANMVMSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDX0</accession>
    <name>A0A367LDX0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_0310</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LDX0"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000700">
        <property type="term" value="F:mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10028">
        <property type="entry name" value="UDG-F2_TDG_MUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.470.10:FF:000010">
        <property type="entry name" value="G/U mismatch-specific DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015637">
        <property type="entry name" value="MUG/TDG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF21">
        <property type="entry name" value="NON-REDUCING POLYKETIDE SYNTHASE AUSA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00987">
        <property type="entry name" value="UreE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="8">
        <location>
            <begin position="361"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="9">
        <location>
            <begin position="1263"/>
            <end position="1578"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="1693"/>
            <end position="1767"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="5">
        <location>
            <begin position="1263"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="5">
        <location>
            <begin position="1423"/>
            <end position="1578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1604"/>
            <end position="1689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1763"/>
            <end position="1783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2143"/>
            <end position="2186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1609"/>
            <end position="1637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1659"/>
            <end position="1676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="2143"/>
            <end position="2160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="2161"/>
            <end position="2175"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="5">
        <location>
            <position position="1296"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="5">
        <location>
            <position position="1485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI12619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="2364" mass="260225" checksum="9DA51A434E5068AB" modified="2018-11-07" version="1">MAVDNTNNNMNHDGTSVLFGPTGAVTTESLLTIRNLLQENADLGFISSTISELPTLWPSIQEAWPPLSKLPAEEKLKELGDFFSSQRDSRSILTEATNNNILSCPLAVISQLIDFWKLTRDGEPLGSSRVRDVQGFCLGFLTASAVSSAKSESQFRHLAVKAVRLALCLGAVVDLDSVRRSDCASTLAVRWKSGAQLQQLRHTMKLYPASYISCTTGSKTATVTVPERDSVALMAKLDLPAMPLPTRGRWHHRDNVEGMQAIALLCEHDERFRLPDAGCLNSQLLSSVNGGRILRGDGALHNIALRSILTETARWDLMFDAMFNVGYRHVSIGEKVVIPRRRRVDASPPDDAISPDTHQKGGAVAIVGMACRYPEADSVEDFWHLIEAGRCVVRPFPQERFRPSDLVREPRGPFWGGYLREPDMFDHRFFRLSGREAKSMDPQQRLSLQVAYEAMESSGYCGLGSGRFDRDVGCYIGVANDDYDCNVASHPINAFSLTGTLRAYISGRISHFFGWSGPSVTIDTACSGSAVAIHTACRALQANDCSLALAGGVCAMTSSRMTQNLIGAGFLSPTGASKAFDIEADGYCRAEGAGMVVLRRLEDAVRHGDSILAIITGSAVNQGSNTSSIQVPDTESQLSLYSKVLDASGTDAADVTYVEAHGTGTQLGDPVEFKSIRETFGRRHRKEDVFVGSVKDNIGHTEASSGAASLLKTILMMQKKKIAKLANFNRLNPKIEPLGGDGVLIPTETREWTAAKRIAMINNYGAGGNNAALILQEASSSSSSPPPARTCAAPSRSFPVFIAGGTAEAVRSYCRRLREFLKPSTRLDDVAYNLAVKQNRDFDNVFATTTDGILDLSAKLDELSSGTAEPQKKASRPKAVVLCFGGQDGRLAHISKALYDDCLLLQHHLAQCEVVCTEQLSLPSLFPAIFSPDPVDDIVKLHCILFAIQYACAKAWLDCGLEVDRIIGHSFGQLTGLCVAGSLSLDDAIRLVSTRARLLESHCGGEEGGVMLAVETSDVDRVLGLAEEQRRHRFAVDVACYNGPRNLVLAGDVESIRAVEDVCRTGGVRAKLLDNSHAFHSRLLDCILPPLLEAAAELRFETPRIPIEACSKESDWSDVVTADKVVRHTRMPVYFVDAVRRIEEQVDGPVVWVEAGSGSAVIPMLKRAVGSKSHEHVYVPSSLRGSDGRLNLAKAVSRLWSIDIRAQFWPFHGSQRAEYGWINLPPYQFAKTSHWLEYKPSQPIWNEVATTTTTTTTTTTMPRELVTLLPSDSQGEAALFEINPSHNLYQFNTSGHEVVDQSLCPASLYIEFVITASHQLADTTSTALVPHVADLTMSSPLVLNPAGRVFLKLVEKTAQSRSWDFSIFSHDQQADDDDDDDTVVQHGKGRVTLSATSIPMLISNFDSLSSLILDRCKEMETCPSSIGFKGPTVYQAMRRVVTYLDYYHGIQSYYTMGNEAVARIQMPAARPAGMGSSFCDPVLTDSFTQVAGVLANCFCIEDDGDMWIVNFIGDVSYTQTFMDDGRKRQSCWTVYSRYERPSPKTLRCNVFVLEPESGHVVVTIMSISFQKTSIRSLRRVLGKLNSRAREGTCIDYEHFITSHDGQHQHQYHRHHQHHQHQHYQHHQHQQHQYHQYHQHQQQYQQQHHHDHHQQQHQQQQHHHHDHHQQQQHHHDHHQPSQDKTATAETDDNQANLQRTKKMLSDVLEIPPQDISSDSSLEHLGIDSLVATELFVEMRKRFNVVVSHPDFAAVSTVQGLAQLTSSSPCSSSSRSTPPSTTSPPSCFHVETVVYGEQDGIPLSADVYYPDETGGRRRSPMPVALMIHGGGHVLSTRRDVRNDQTRILLEAGFLPVSVDYRLCPEVTLSEGPMRDVCDAFCWARQTLPTLRLGRHDVQADGERVVAVGWSSGAHLAMTLGWTASSAGVRPPEAILAFYGPTDYEDGFWRRPNRPFGQEPMPPPPGEGYHHLYAGLYDEPIVGYSPAASLRAMGGWMSLDDDRCRILLHMNWQGKTLPVLINGLERTGSKCVTSPSAPSVQQVRDVSPLAQIRAGRYKTPTFLIHGSRDDLVPWQASQRTYDALREMGVAAGFEVVEGGLHLFDVFLSSKRDAGCVEAIERGEWVMPDDGFCLDRFRYDAETDSPTRLLRRPCSSSTPSSPSPSRRKPKPKPKPKLKPKGQQANGHDRLPLLPDALAPNLVVLLVGLNPGISTSISGHAYAHPSNLFWKLLHASGTTPRLCLPAEDALLPQLFSLGLTNLVARPSRSGADLGRSEMDAGLAVLEAKVGRWRPEAVCLVGKGIWDTVARGKMIPRTAFCYGWQHHCRLGAVEGGWEGAPVFVASSTSGLAASLSPAEKLRIWTELGDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LE06</accession>
    <name>A0A367LE06_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0377</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LE06"/>
    <dbReference type="STRING" id="1330021.A0A367LE06"/>
    <dbReference type="OrthoDB" id="5339776at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025040">
        <property type="entry name" value="DUF3984"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13136">
        <property type="entry name" value="DUF3984"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="371" mass="40857" checksum="C7086EA2E8815A68" modified="2018-11-07" version="1">MDLAYDQHTERARRKDRSSINNGHHLSLAPLTVKLPLDGDDVGDGQPFPPYYNGRSSSYLQGKSAPTTPRLLSRPTTPSAARSRSHHRRRPSAPIASNRPASGTATPRRRGLRPDDGGPLGIGLRDGPDGDWLLRTGALITSEAREFKGQSWLVSRQSSTSLAGMRDNDDSNDEDAAREDNEAREMMASRRGSRRGSSDVDPSTPNGSRFNSRYTSRRQSIAESRSFVATPLHQPDGAYFDDVAPDFVHLDARLEELELDTADEDEAAVRRLVRHGHAGKGSWISNVIGWSLFSVNEDEDDDEDDEDDDEDVEESDEKRSEGSVSPSGRWPARRASNTTGGPLERMPLPAKDQGGWRDAAWLLDVASKVAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEB0</accession>
    <name>A0A367LEB0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ABC1 atypical kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_1044</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEB0"/>
    <dbReference type="STRING" id="1330021.A0A367LEB0"/>
    <dbReference type="OrthoDB" id="427480at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13969">
        <property type="entry name" value="ADCK1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045307">
        <property type="entry name" value="ADCK1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF19">
        <property type="entry name" value="AARF DOMAIN-CONTAINING PROTEIN KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC1 atypical kinase-like" evidence="2">
        <location>
            <begin position="155"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI12759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="588" mass="65505" checksum="BF80EDAFFF32D522" modified="2018-11-07" version="1">MKPWTVTRAAARLRLAVATPAPASSWSSTLAPRTRRSGSWRPSRSALLFASTGIAGTTLAFTDEIKSGYEAAERTGRVATALVICINDYRTTLNAKAASDDKDGGELLKACHKRCAERTLRVLEKNGGIFIKLGQHLSAMNYLLPPEWTTTFIPLQDQCPVSSFESIQNMFRRDTGKELCDYFSEFDPEPIGAASLAQVHLATIKDSGKRVAVKVQHPDLQAWAPLDLALTKYTFSTLKRFFPEYDLEWLSSEMELSLPKELDFQEEAENARRMKAHFEKVPALPLIIPQVIWAKKRILVMARESGCRPDDLEYLDSNGIDRDEVAATLARIFNEMIFGDGAPLHCDPHGGNLAIRKNDSRRHHLFRSGPNFDVILYDHGLYRDIPLPLRRSYAKLWLAVIDGDLDRMRRYSRDVAGIGDQDFPLFASAITGRDFGVVSGRGSILETRTADEEQSMSGALQEGLIVDLVQMLSRVPRIILLILKTNDLTRSLDENLQTRQGPIRTFLILARYCARTVFHEQLDDIAARGSLLWPSNALNLLVAWLGYLRVEVKLEAFELALAFKRALGLRPADLGSGGNPLGEPAGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEJ1</accession>
    <name>A0A367LEJ1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEJ1"/>
    <dbReference type="OrthoDB" id="4903873at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016968461" evidence="1">
        <location>
            <begin position="22"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="182" mass="20602" checksum="F6E5F04ACE928568" modified="2018-11-07" version="1">MMKSCLLFSAIFSSLLHTSSAHEWCPHRQECLPERIYLDGGRELECRYIHGDLHCKTMHNDDSSSDVTEQLSSHGPIPQNRICPRFDGKEFSTRTADGNVATWHVHCNTAVVNPLPRPYPCPAGSVTQILEQRQRNGDYRGLYWDLGGVCQDVLPSEAGWTAYRTLPADAHAFIRRVDFKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEK1</accession>
    <name>A0A367LEK1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEK1"/>
    <dbReference type="OrthoDB" id="4941368at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="167" mass="18577" checksum="449C72D284F07385" modified="2018-11-07" version="1">MWPLYQPVLTSASSHHRFTMNSSPDPRFSMSTEAGPSRCHMESSFYSILHSSGFAEWAARAESQNSRLRAGGKLDGESSLGKHGDDSSSPVRSLHTSSDEAEPRTAQTSKKSSPDAASRLTDEAANEAEQSDDGCHIENFTWHYSNYSSMDAELMILKKHLMKRTRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEV0</accession>
    <name>A0A367LEV0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_1324</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEV0"/>
    <dbReference type="OrthoDB" id="10261634at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="293"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="10">
        <location>
            <begin position="58"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI12941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="373" mass="40942" checksum="A79ABF4830665176" modified="2018-11-07" version="1">MARQSGDEPVALLAPEEQDGEFKADVRDVESEADSESLPNQNLDHEYSIPSTVKFTWLGTYFFFSLLLTLYNKLVLGMFSFPWLLTCLHASFASLGTYTMMNMGYFKLSRLGRREYLALLAFSALFTANIALSNLSLAMVSVPFYQTMRMLCPIFTILIYRVWYSRTYSGMTYLSLVPLIIGAAMTTMGEMTFTDAGFLLTILGVVLAAVKTVVTNRFMTGSLALPPIEFLMRMSPLAALQALACATVTGEVAGFRDLITSGNIALGPALASLAGNGFLAFLLNIASFQTNKLAGALTMTVCGNLKQCLTVLIGIFMFRISVDMLNGAGMAVTMIGAGIYSKAELDNKRKNRQPAYEALEQKPRTIRDKLYPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFW2</accession>
    <name>A0A367LFW2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFW2"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="186" mass="21896" checksum="58F5DFF1926B3FAE" modified="2018-11-07" version="1" fragment="single">LDQYESSGRAVKRRRLPQPSLPSLPKTQGKKDMRHRLMVLKHMKNQKSDIQGRIRSHLSQKRLVWDSSGNCECDMEISSREKDNGKHEQKLTLDATQELETCGERALGPETDLLHGRFSWEKKTYFCVPSEREKRKTSYLVRRRLLLQQMGHERHTRAVRREQEEDDDDETEGKKRRTRGTRGNPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFX9</accession>
    <name>A0A367LFX9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_0328</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFX9"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI13333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="210" mass="23449" checksum="64E55F2D7226AF18" modified="2018-11-07" version="1">MAQVYFDRLWTFPLPPSPRHCPPPIFFPRPLWPTGCIMSVAAVQPSSSSLHVTFSNLELANRKKGHIRMGFSYLLFFLFPSTKMKGRNGQKQIKKNEKKRGGGAKLSSALSSLDLSASETVQFYHSAYGTMQDTDRQTLRALVEMGGTGNKVGWCCFGSGKWVYDAWPCSSTPNPSLLFRYDDSSTAPNPSRDRSCLFSAMHVNFSSLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGE1</accession>
    <name>A0A367LGE1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Adenylate kinase isoenzyme 6 homolog</fullName>
            <shortName evidence="10">AK6</shortName>
            <ecNumber evidence="10">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Dual activity adenylate kinase/ATPase</fullName>
            <shortName evidence="10">AK/ATPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_5527</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Interacts with small ribosomal subunit protein uS11. Not a structural component of 43S pre-ribosomes, but transiently interacts with them by binding to uS11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the adenylate kinase family. AK6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="10"/>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGE1"/>
    <dbReference type="STRING" id="1330021.A0A367LGE1"/>
    <dbReference type="OrthoDB" id="10251185at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000372">
        <property type="entry name" value="Adenylate kinase isoenzyme 6 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00039">
        <property type="entry name" value="Adenylate_kinase_AK6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020618">
        <property type="entry name" value="Adenyl_kinase_AK6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595:SF0">
        <property type="entry name" value="ADENYLATE KINASE ISOENZYME 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595">
        <property type="entry name" value="POS9-ACTIVATING FACTOR FAP7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13238">
        <property type="entry name" value="AAA_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 10" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMPbind" evidence="10">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="10">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="18"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI13485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="173" mass="19907" checksum="6F96148A3D5F0914" modified="2018-11-07" version="1">MRQLPNIVVTGTPGVGKTTLSEKLAERTGLRHLSVNRIIKDRACHEGWSEKYQSWIVEEDKLLDSIEADVEAGGCIIDWHACDLFPCSWIDLVVVLRVDSSTLYDRLKSRNYHESKLQENMDSEIMDVLLQEAREAFDNKVVLELISHTPLDLERNVARIKNWIAKWESTTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGS6</accession>
    <name>A0A367LGS6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGS6"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="78" mass="8425" checksum="0E05EBE4A1CA0123" modified="2018-11-07" version="1" fragment="single">INYFSGSARYSYTHTQGTRPEGLGGSRDAGPAVAGPRPPYVTEAERHNNVGGGYAVQRLRPYGPYGPYEGRNVGRLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGY6</accession>
    <name>A0A367LGY6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7979</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGY6"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI13680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="144" mass="16540" checksum="D1A69AFD02180BE9" modified="2018-11-07" version="1" fragment="single">RPIDSSQRSSQRSARCTYSGHSTRLISAQGSRHIDRRAVLIAVIALDHDRRAVLIAVIAPDLDSRTKSSSKSPIFQVKYLKKENTYEQTERFYYKLQLYYFFNTITSPAFNSSLILTKPLLRNSSSSSLSRDPYLDYLLLFLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGZ3</accession>
    <name>A0A367LGZ3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGZ3"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="100" mass="11003" checksum="E716DB91185A2984" modified="2018-11-07" version="1" fragment="single">RGRVRTYRGYSGRVIAVIAGVIGLPLNYRSSKYVRVLQVGTLKYLEKIISISFSHLLNTNTSPASNSSSIASFRLSRDSSSSSLLRDHLPDSSTLYPLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LH68</accession>
    <name>A0A367LH68_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5643</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LH68"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI13592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="91" mass="9870" checksum="ECA530C22C4A0A9C" modified="2018-11-07" version="1">MHPIRTHAFNSLARVVLQENFRAVWAIMDTTDETSLPATITRAIQKSVESAVQKVLQPYATRSKPSWAAVLAAPATAPPSGPPLVRLVPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHB0</accession>
    <name>A0A367LHB0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">SAM-dependent MTase RsmB/NOP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_8021</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHB0"/>
    <dbReference type="STRING" id="1330021.A0A367LHB0"/>
    <dbReference type="OrthoDB" id="6093671at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016428">
        <property type="term" value="F:tRNA (cytidine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057285">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057286">
        <property type="entry name" value="PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023270">
        <property type="entry name" value="RCMT_NCL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018314">
        <property type="entry name" value="RsmB/NOL1/NOP2-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808">
        <property type="entry name" value="NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808:SF1">
        <property type="entry name" value="RNA CYTOSINE-C(5)-METHYLTRANSFERASE NSUN2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25376">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25378">
        <property type="entry name" value="PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02011">
        <property type="entry name" value="RCMTNCL1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01153">
        <property type="entry name" value="NOL1_NOP2_SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="12">
        <location>
            <begin position="56"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="475"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="866"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="475"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="522"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="566"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="584"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="880"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="903"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="175"/>
            <end position="181"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="269"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI13800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="933" mass="104612" checksum="14B7E6486F22827F" modified="2018-11-07" version="1">MGRKGFRGKNRRGGGGGQSRGSGSWRDYSHMVKENEKLMSYYNSLLQLPEPEAQLFWDALRRELPNSFRFCGSKGHALAVKRLLKTRYIPEIVKIEKEDGTPVEAPMPVPWYPDELAWWMTTPKNVVRKFPPFAAFQKFLVSETSIGNISRQEVVSMIPPLLMDLRPGMTVLDMCAAPGSKSAQLIEMVHRGEEARVRKVLRAFAEEDGLDLGRETQDEIEADLEADPSDNGRATGLLIANDSDYKRCHLLVHQLKRLSSPNLIVTNNDATQFPPLKLPSTDASSKNVYLKFDRILADVPCSGDGTLRKNANLWRDWQPGNALGLHHTQVRILVRALQLLKVGGRVVYSTCSMNPVENESVVASAIERCGGPTNVDIVDCQDQLPALKRRPGLKSWTIMDKAGRTWRSWAEVESFAKEENEGQIPGRVAQTMFSEGQGSDRGLLPLERCMRVYPHLQDTGAFFIAVLGKRAEFKARNENEPKRAAENEDGAVDVKDLPEVKDASEAKGAPEAAAVLTTEESSSVKRDDRVQGTKRPSDATDDDHQAAKRLKAEDEEEKEPDDASKTENGQQNQGSKRPSDATGEEQHAAKRLKTGDGEKTEMDASTSTGDDDGQQKVKKTIKPEEDGKQQANNAAQGGEGDGTDKTKAQMRPPNKTHNAPPEEPFKYLDPSHPIIQNIKHFYRISTRFPDNRYMVRNEMGEPAKAIYYTTALSRDILTENEGRGVRFVHGGVRMFMKQDAPSAEVCRWRIQAEGMPILQGYVGEPRVVHLRNKETLRKLLIEMFPRISGESWRDFDEIGDQVRDVGMGCCVLRIEPDGEDADFSERMALPLWKSIQSLNLMLPKEDRAAMLLRVFNDTTPLINTTLQKQKQQKKKKEEEEKAEEEKAEDEEEGKEGRESADKDVDDDNDAAIEDMPTPEEMMVDQASQQEVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHD2</accession>
    <name>A0A367LHD2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7925</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHD2"/>
    <dbReference type="STRING" id="1330021.A0A367LHD2"/>
    <dbReference type="OrthoDB" id="5388207at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="277" mass="28998" checksum="D899CDE01157649C" modified="2018-11-07" version="1">METVSNMAAQAAKLVWGGNPEEKEPISGAQGNVSRGEPFDAGNMDPSHQQTMSTTAGSNRDASTQPNIGKSSHVDNSRQVDPISQPSTVAAAETETPKVTDERESQVEERVTSSRTSDDGASKPQTADDSRAPKTVSGKGSATTGKATEESHDDGETGDPNTGIMGDGPKPLDVVAEENGGDAGNNVDTKHKSENDDENDTRSRDQKSKGTGEMHVMTSGFAADGGDFDATKPGAGREADRLMEEKKGHAGAEPDGTGSTQEKPSLGDRLKNKLHKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHE7</accession>
    <name>A0A367LHE7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_8261</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHE7"/>
    <dbReference type="STRING" id="1330021.A0A367LHE7"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI13864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="122" mass="14004" checksum="61BAB6E2F75FDD2F" modified="2018-11-07" version="1" fragment="single">TRCKDIRTFSRKKGEFNAFLTNLKDKIRTNKATFRDKEDRIGFLFRSLKGKACKILETYLLTKTKDDSLSYKDFCGYVKDSAIKRLDAELVLPNDLPALAKYSLSILLPKTPLLNRQIDPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHL8</accession>
    <name>A0A367LHL8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_8165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHL8"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI13934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="84" mass="10167" checksum="1771762066AEF9D0" modified="2018-11-07" version="1" fragment="single">TRYKDIRTFSRKKSEFSAFLTNLKDKIRTDKATFRDEEDRIGFLFRSFKGKARKTLETYLLTRTKDDSLSYEDFYSYIKDSVYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHN5</accession>
    <name>A0A367LHN5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_7949</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. DCP2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHN5"/>
    <dbReference type="STRING" id="1330021.A0A367LHN5"/>
    <dbReference type="OrthoDB" id="18996at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140933">
        <property type="term" value="F:5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03672">
        <property type="entry name" value="NUDIX_Dcp2p_Nudt20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000003">
        <property type="entry name" value="M7GpppN-mRNA hydrolase isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1050">
        <property type="entry name" value="Dcp2, box A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007722">
        <property type="entry name" value="DCP2_BoxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036189">
        <property type="entry name" value="DCP2_BoxA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044099">
        <property type="entry name" value="Dcp2_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114:SF17">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05026">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01125">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140586">
        <property type="entry name" value="Dcp2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="10">
        <location>
            <begin position="91"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="282"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="444"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="616"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="466"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="488"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI13909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="662" mass="73088" checksum="4C216351FF545AC7" modified="2018-11-07" version="1">MAGSHMLLEDWLDDLCVRFIINLPEEDLSICFQVEEAQWFYEDFIRPLDPTLPSMSLRTFCLRIFQHCPLLASFSAENHAAAFEEFLQYKTRVPVRGAIMLNHAMDSVVLVKGWKKGASWSFPRGKINKDEDDLDCAIREVYEETGLDIRAAGLVGQKKPKSIEISMREQQLRLYVFRDIPMDTDFQPRTRKEISKIQWYKLSELPAFRKKGDKHNYTGAANQTSKFYMVAPFLVPLKKWIASQREMDQKAAVSVNPANLVHQYSAPEEAFSVDDETWATDQRCAPGGHVPPRTQLHTKAPEAAQHQDKGSALLSILQAGNAQSRGVQTPFDLVDAEPALPRNPHHHTNQNHLLSYASVQGRPPPSFPLASNQRAVSSQAGVMGPALQSFRHDASPALPQTLTPQMLQDVLSRSASRGAPIFDQDIPIQKHTGSGLPLAQAMQGSRTAQVDGHSTALTTRMKRDATPTNANPYTEVSSRSLATPQPPHSSSSGLPGPGANTSTDHRNALLGMFKRSEADAIRQDTQAPSFGPLPGQTRVAQSMAREEKTMPFVHDGGSGVQTPMQPWQILQRSHRVGDDSRYESARLADTAAAKRVASREQKMQLLSLFGGRQENATLGDGGEGATVVTSPRADREVKTPMSPADQSFVLEYLQTVTSNAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHZ8</accession>
    <name>A0A367LHZ8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_8039</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI14041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHZ8"/>
    <dbReference type="STRING" id="1330021.A0A367LHZ8"/>
    <dbReference type="OrthoDB" id="5417887at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF155">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016951866" description="Rhodopsin domain-containing protein" evidence="8">
        <location>
            <begin position="20"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="223"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="9">
        <location>
            <begin position="73"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="335"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="350"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="362"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI14041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="372" mass="41147" checksum="B6AB5EA462440C93" modified="2018-11-07" version="1">MKPRLLFLFFSFCIIRYHSLTPSPSPSSSSLPPDHVDLSSTSSTGCFVPLPWFTPDATQQVVNHISSTASVALRLISRNLREEQGRWGFDETCLIFAMAVVLARSVYITYCIHLGFGRHLHPLLEADVVGTVWLTRHLVILEALSLWTWALPKLPVAILLFRIFGKFKRGLGIILYSLVAFLIAIVVVQTVVTFVKCQPISKNWNPTVPGRCWNTDIYTDIGYFAGAYSAALDFGFALFASTQVFGLQMERSRKMLIAASLSLGIPAGVTTCIKLAMIASLNTSDITYSTVPLEVWNSVESCALMVAACVPATRPVMRLLGKRLGEWRSLISGRKSHSSAKTESSSGVSSKDRAGELELGRRGQQQQQRRWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LID1</accession>
    <name>A0A367LID1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_6072</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LID1"/>
    <dbReference type="STRING" id="1330021.A0A367LID1"/>
    <dbReference type="OrthoDB" id="5397827at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI14175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="247" mass="27845" checksum="3D91A88A49128A34" modified="2018-11-07" version="1">MTSSTTATMVAASGAYLRRRIFIGVRFPTIYFTRLSSSSSSSSSTTDRPIVLEKPTKFNPPSHGSRLRKGGALPRHYAPPLSAAEAAARKQKDYPGVMAPEGSWAHWMWHSRLLHTFITMGALFAMAIATFFLNYTHNSPFKDLVPAISDLWQRPLYFFSAWKNVIILHEKDNSAKAVDHRMAHLDDVAKRRYYMKMHGIEPKDPVSMVFGKGQNKLVETAATVPDMGSVLDVEEKPAQRKKWFGLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIQ8</accession>
    <name>A0A367LIQ8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HAUS augmin-like complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_6054</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIQ8"/>
    <dbReference type="STRING" id="1330021.A0A367LIQ8"/>
    <dbReference type="OrthoDB" id="66964at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="36509" checksum="2BD36C610C0C8089" modified="2018-11-07" version="1">MLPPLDEETLRNNPAFANLYSSLTQTFLHPDGSTRHDEEAEERAAVEQELDKWRFSTAKDRLIEHALFTAHLQQRSSLPEPLLELLLLLPPLLAHEQPLASESTDMLLSSRPLSDWETLLPDVASLTSSSLHSTALNLARVFHPTTNASYLHRQIPRLPEHYTTIRTDLVAAKRSLVKSRMRILAALGRLLGCYSQSLVHLVRSLEAKHGVVARSLELRASDVCLRAQRTDVEASGAVHEINRDLYPPQAIDALHNYAECLKDSKLRVADRVRQLRADLGEYGVGVAGCEDKEKMFTEMAVVYRDLSGQIADVKSRLECLQSPAGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJ55</accession>
    <name>A0A367LJ55_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJ55"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="79" mass="8543" checksum="D657113164B65200" modified="2018-11-07" version="1">MFRKKSKVREGVDVGAALRCARPRRPTIGRERLRRPPLACSECPIRGSIGGISVLPREPRVCGSSPILVLAGHFAIPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJV4</accession>
    <name>A0A367LJV4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_6932</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJV4"/>
    <dbReference type="STRING" id="1330021.A0A367LJV4"/>
    <dbReference type="OrthoDB" id="441771at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030692">
        <property type="term" value="C:Noc4p-Nop14p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025239">
        <property type="entry name" value="DUF4187"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007276">
        <property type="entry name" value="Nop14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23183">
        <property type="entry name" value="NOP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23183:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13821">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04147">
        <property type="entry name" value="Nop14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01173">
        <property type="entry name" value="DUF4187"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="G-patch" evidence="8">
        <location>
            <begin position="995"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="60"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="148"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="273"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="945"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1008"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="298"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="398"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="435"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="462"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="952"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1029"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1048"/>
            <end position="1065"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI14704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1228" mass="140396" checksum="D2A16E5561CD1B89" modified="2018-11-07" version="1">MAGSQLKRLKASLREQGITGPQQSKKQKRKAAQDSRARGEKKLQRGLVLDGIRQQFNPFDLKHNARGPKFEVTTNRPVTGDVARGIKGRPTQARAAGEERRKQTLLVEMQRRNKVGGILDRRFGENDPTMAPEEKMLERFALEKQRSHRKRSLFDLEDEETSEVGLTHMGKSLTFDDEPADDFHEEDLDAADDSDGSVRERQRLKRVRSMAAVPGEEEEAEQPERKKTKKEVMQEIIAKSKMYKHERQAAKEDDEDMRVELDKELSDIRLLLSTTTSNAKRSGHGELSVPTIGGTNRDAFEKEYDLQVKRLAQDRRAQPTERIKTDEERAKEESERLQKLEERRQKRMRGEEVSDTDSDSDGDNNKALDTTAQEEEVEDEFGLGSGLRTRPTAKEVVFDDEDDFVIDDDLVASGSDFEEVESDDEDDVASAQGEADVEEDDEDEFTKGLLNEEETSNPIFKLTSTPGPSTTPLPKSDNDGLPYTFPCPQSYEDFKALTEAFPRGSLPTIVQRIRALYHPKLDSKNKERLAGFAAALVDFVSSPWEEKTRPPFSVLESLVRHIHSLAKMFPVEVGSRFRHHIGEMGRERPLALRPSDLILLTAVGTIFPTSDHFHQVVTPAMLVMSWYLGQCVPREMSDYAVGVFLSALTLQYQQMSKRYVPEVMNFCLNALCALSPVSPTEQLGNFPQHEPPRGIRMENAQAIRLRPLRFTDCDSADVEGEKAASLKAALFDTCIRVVEGAAELWSGKSAFLETFEQAARVLKHSRSEGCLEHLPTQLLDRAEKVEVKLGRMIRLAQLSRRPLELHHHRPLAIKTFIPRFEERFDPDKHYDPDRERAELAKLKAEHKRERKGVMRELRKDANFMAREKLRIKKAKDEAYEKKYKRLIAEIQGEEGREANEYEREKKAHQAELLSSIMSLPYVKKETSGDEDDDYMKMTFDDANRVQESSLQRTRRLKKESHARGFVKSKSSLAAETAAARDKALSMSLLENPRTKNSKGLAMMNKMGFTGGALGSGPDSSGPTEPLKPTIKEDRGGIGHEPVKKRRPQRDAAANEHETKVPRTEPGEYRERNRNMHAEGRLRGKMHGLQRIAMELDDKVSYDANVRRPPLKDLPVVYRGKVRRRERKLRDERARRQTYYRRPMCNNDEADGDDRMALGLDRDAKEDVVDELDETDDELDSFEAMAPRDQFIQTLSYLRYQHRYCFWCKMMYPNDKMEGCPGLLEEDHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LK58</accession>
    <name>A0A367LK58_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_6395</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LK58"/>
    <dbReference type="STRING" id="1330021.A0A367LK58"/>
    <dbReference type="OrthoDB" id="161814at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF115">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI14816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="129" mass="14936" checksum="70B0AA9113A6C077" modified="2018-11-07" version="1">MLFTWDTTNLCIVFRQWHIRSTASLIFSLLAVILLAMLYEALRALSRRFEASQERRIAAMPRQNHYQASQRAQVIKSLFYALQNFYAFMLMLIFMTYNGWVMIAVSLGAFFGYLLFGQATSATKDNACH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKE2</accession>
    <name>A0A367LKE2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_6994</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKE2"/>
    <dbReference type="STRING" id="1330021.A0A367LKE2"/>
    <dbReference type="OrthoDB" id="1708389at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021709">
        <property type="entry name" value="DUF3292"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38694">
        <property type="entry name" value="CONSERVED EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38694:SF1">
        <property type="entry name" value="PEROXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11696">
        <property type="entry name" value="DUF3292"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI14894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="685" mass="75129" checksum="67F90BF059D9EA27" modified="2018-11-07" version="1">MIVSEPTSDSGLPRWRHNNSSPQPRPQGPDHGRETGPTMVQSHDDSMPTASHALAYESIRREAPELKGVSQMEHDEVEVKNVGWNDKGRVVSQQVMGGLRNDELWTLIRRFNKFVFRVRSIEEAPLATTLDMNVADEDDFSPDKLRATLERLYMTVLVSLLSGWKHVARIRSWREHRRTAVFTTVYAAAWFYDVLVPTVVVLGMTLILFPCSRAACFPPVPPALVSATTGGVQKPAAGVLASTDSMTGAPEKHKGEAVEQEAHNFINTLSTLAISATAGKQPQGDAHDDDDDDDDDDDDDDATKLADGVANVRRTNGSIHDQTREPVSRAVWNEARPLMHLVCSLNDTWERFANGLSPTRPFPRLRPRLVLAACLVPVLVTWWLMTPYMLLKGLGFVLGFGLFGEPVVALSVDVADRFYPPWRHYVQVRNSVLRGVPTNAQLTITLLRVGERNKAPLPPPRKTKSAPKAGSDWGAAAGELDNMGATDAEKRLALEPAAQPNGDDELNDESDRRGIQTNRLFNLVKKTARSGVAAALAADKAKAAVGAKRARQRLGVVRRASSGEEEEEEGGPVRFPARYGGRGGHAYVTSTATAPALSWASTCPRSGRSEPVWTVAIGDIDRITKVGGLGWKRKMVVGWALDSRIIDGLVVRTKQGDEYQLTAIVARDELFNRLIAIGSQMWEAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKK1</accession>
    <name>A0A367LKK1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7107</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKK1"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="82" mass="9036" checksum="7ADF4949CB707C56" modified="2018-11-07" version="1">MFRKKSKVDKIVRLPYILRVDVGAALRRARPRRPTVGRERLRRPPLAYSECPIGGSIGGISVLPGEPRPILVLAGHFAIPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKN2</accession>
    <name>A0A367LKN2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKN2"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="74" mass="8220" checksum="78DECAB531C9D052" modified="2018-11-07" version="1" fragment="single">VYVRLALGITRHYALTEENYADGKEDREALQIRGCFAGSEGIADLAVAYKDYINPCVSPRLAKNMPNPFIDDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LL95</accession>
    <name>A0A367LL95_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7098</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LL95"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI15205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="202" mass="23024" checksum="EA0DBFA1CD7FB962" modified="2018-11-07" version="1">MSAKLVNYARIASNEEDIRRIAATGYKEAIKFFPEEKRPTSPERIYKKSFNKANKKTTAPNPDKLYSLTNRERNRYALGFYSRLIVTAGVQGQDIEASSDAEDRDIAINIISDNPLDPSPSDRCVQPYNFGYYNLTNTDINRQKGAQKEALLAATNLRRRLNPEFRKDKVTNMLANKIVSKKIPISIANLIYLIPKFRYLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLB2</accession>
    <name>A0A367LLB2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_6774</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLB2"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI15226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="160" mass="18142" checksum="00EB106CEC5EE50C" modified="2018-11-07" version="1">MAYVFVGWVSLFSKMSSERDEEFKATGGLKRCFIRGVMSGMVHRKATSRNGKGRTEECGQRAAECVLVCVCVRVFECVCSGSVIRREREDGNWNEMMMGWDGMGWRYVRKQLLLPTLSIATSQQHGTWVPCLGDFNDCSTMTSTDSQHQRESNRFDTSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLF7</accession>
    <name>A0A367LLF7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_6925</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLF7"/>
    <dbReference type="STRING" id="1330021.A0A367LLF7"/>
    <dbReference type="OrthoDB" id="5416384at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF8">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="49"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="614"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="742"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="620"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="643"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="767"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="803"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI15230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="935" mass="103573" checksum="BE849135B6A7DE43" modified="2018-11-07" version="1">MDPAHIFRQGLGSVPPRQHLGQSQRHPQGLPDLSDHDGSGQRVAHTLTACCRCRQRKTRCDPTLPRCLPCERSGSTCEYLDTTKGRKINRYYVVRLQDKVRALEAELRQYTDDGNDYPCSNEDILRPGGMIRVGASDETPRYLGPSSGIAMSRLLMEEAKRYTDSHRISELIPQVRRMQSVHMSANRQKSYPVISDHPAESLPKRETAENLARVYKQKSQLLWPLLHEKDFDRDLAAVYDGDDDPYKNFVIRMAIAISLQKLEIQYAGLADSYYVAAMRYAEALIRPKDLKTLQCLLMIGQYSLLTPARTPFYYVIGLATRICLQEGLADEQTITAGFNLDPQTLDMRRRLVWIVATAECGLSYHMGRPSGFATSDDRLDVAFFAPVDDACITPNGIKPGPPSDGKLVAIHIYKTRQFQAEIRRVLYEKKRAEPKNDSHPWFAQVEQKLKAWLDEAPVNPRGFRSWYRHLHSPPLLSEPSSDGQSRFIGYYHYLRVALYRPSPQVPQPSPRAAAVCFESSASVLEQAREQIKDGAVSITWIFLLTLNLALDALLWATSYADVRLAHPRAEVEELVDESLLCLDRCAERWPGTAYTSQLYRVIAKACLQSYESTGVDGQQPPLSLASPSPAVDKSVQLADSSGQQQQQQQQQQHQRLQQQQQQQPIPFLNPPQFGIVFDSPAEPMDTFAVDPNFPPHPTFRSNSIFCNPATESSGRRFSYFPPDFNQSGDGAQLDVLTVPDHILASPPDQSACQLPTPPESLPTGGLTNSTPSTTFSPTGMAPATDASAHTSPDLKMMPVQTANPPPAPHPGPGPTPAFDASSRLPLPAQRPLPTTTGPADCFTSPASFFSPYNFGSGGAGFFNDVMHNPFADTGPVTGLGLQNVGFDPSFFPQSRQGSLTHEQQEELMKVLETDGAGDIEAFLSAGNGVPDGTWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLM4</accession>
    <name>A0A367LLM4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fanconi-associated nuclease</fullName>
            <ecNumber evidence="8">3.1.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_6388</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Hydrolytically removes 5'-nucleotides successively from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.</text>
            <dbReference type="EC" id="3.1.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the FAN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.1" evidence="8"/>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLM4"/>
    <dbReference type="STRING" id="1330021.A0A367LLM4"/>
    <dbReference type="OrthoDB" id="76364at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070336">
        <property type="term" value="F:flap-structured DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004528">
        <property type="term" value="F:phosphodiesterase I activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22326">
        <property type="entry name" value="FAN1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1350.10:FF:000009">
        <property type="entry name" value="Fanconi-associated nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033315">
        <property type="entry name" value="Fan1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049132">
        <property type="entry name" value="FAN1-like_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049126">
        <property type="entry name" value="FAN1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049125">
        <property type="entry name" value="FAN1-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014883">
        <property type="entry name" value="VRR_NUC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15749">
        <property type="entry name" value="FANCONI-ASSOCIATED NUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15749:SF4">
        <property type="entry name" value="FANCONI-ASSOCIATED NUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21315">
        <property type="entry name" value="FAN1_HTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21170">
        <property type="entry name" value="FAN1_TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08774">
        <property type="entry name" value="VRR_NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00990">
        <property type="entry name" value="VRR_NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VRR-NUC" evidence="10">
        <location>
            <begin position="713"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="491"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="589"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="268"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="590"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="620"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI15318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="840" mass="96351" checksum="137BF22C3F6801F5" modified="2018-11-07" version="1">MEERPTKRLKTEKPQEFSWEENDDESTVYAGKSRGRDGMTDVENVLPPTQDEDEAVDQYQLIKSQQTDGGSKFVRGKSSIYVDAFNLALDTVLEQESELFDDKEKEVFEQWRGLDYESQYLYVRLFLRKTWAWHRCSRLRYHSDVSDLDGAIESLQRTRELPHLEVAQEGPPDFDVEPFKLGGSFTFADASEDHIKTMDEAASLLYLDELKILAKEAKFQGRNKAELVKGLCRTSQQQTGLAAVGLLLLLPRRRRRRDSDSPARLGREEEEEEEEEEEEHSNRDRHFMGRVMAMAGRCIRLSSSTQKLFERVHLVFYRSTQWTEKSLTTVILAKMARRNFPEYIVCRTRTIFASRMHLLEYEAAIRLEAEVEGMLEGKGATPTEADMQRMEETSRRILPRWRTLVAEEDDKERTVYEMGEGPYLRRFNPAHSYTRILHKCLWVTGRRKEYGKEHKMLTELLAQRLFHTARRGAWYQRKALVEERYMAAAEKEKEKEKEKDDDDDDDSGDGGGGYVDEDSIIVKRWKRAAAATCEAGLQDPDCHLIYHHDLQKRLVKLEKKLRIPRRLQHDFGHVRLSEPVEMTIEGIQVTSTTSNSSSSSSSSSSSSSRRTIWLDEAEETTTTTTTTTTTTTTTKTCTVEEMCLSHFRNQGWKGYHSEGGIVRTLFAYLFHDILFSYMPNVFQTAYQTCPLDLFTDAFFPARSSAINGRLAEIANGRAGHILRRVWEAHHVRRPVVAGLDWDFDVDDLVDLVGCFPGGALASVCLVVAQEYRQRAGGVPDLILWRRGGRRCGDEILFVEVKSANDRLSDSQRLWLHVLAGAGIKVALCNAVAREVRTLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLZ5</accession>
    <name>A0A367LLZ5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_3466</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLZ5"/>
    <dbReference type="STRING" id="1330021.A0A367LLZ5"/>
    <dbReference type="OrthoDB" id="9987011at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048273">
        <property type="entry name" value="Luciferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38695">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38695:SF1">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI15429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="192" mass="21477" checksum="B9AB60B0C81831B3" modified="2018-11-07" version="1">MSAAVAPSHLRAVALSSYDATEPPSDIQHRPLSITLDGPTIIALALSLVLLIHFLGCHPTEILVSLTTIFLLVRNDYRNFVSLGPGGHPSTFRGYLRVSWLRLWAIRDPFTAPSPDPTRVLRRGILASRPLPYRPSPRPRVFCRCPCRRISSWSMPLEVDELELHVTYRIIEAAIWCILAEHVELGPSLNQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMK0</accession>
    <name>A0A367LMK0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF962 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3378</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMK0"/>
    <dbReference type="OrthoDB" id="2124888at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046521">
        <property type="term" value="P:sphingoid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009305">
        <property type="entry name" value="Mpo1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28026:SF9">
        <property type="entry name" value="2-HYDROXY-PALMITIC ACID DIOXYGENASE MPO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28026">
        <property type="entry name" value="DUF962 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G05310)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06127">
        <property type="entry name" value="Mpo1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="21257" checksum="953FDD2C3A264492" modified="2018-11-07" version="1">MSLDLEKHLTFYGAYHHNSVNVAIHMVCVPLILVSAFCMATYTDTLIQTPPWLSVPNLELNLGTIAAMVYASLYVLLEPVAGFVLAAFCIGSAAFANHLRSEAPQTTFRAALVLHVVSWIAQFVGHGKFEGRAPALLDNLVQAIFLAPMFVWLELLFKLGYRKELQSRVEKAVRLEIAKFRSQSQGKNGKGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMM4</accession>
    <name>A0A367LMM4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_3562</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMM4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI15637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="164" mass="18831" checksum="13B5BB7E08DAF922" modified="2018-11-07" version="1" fragment="single">DIVSAQRMLSPALPFPHPLVPWIVEESERLGLSLSLGRSLPSVEAQIFRNMDIRRTLIRRHQDDTYMYMLHLYVVRHRRVLRPSFIIRPSFIYRSGPKQPCIMQVLGKPYELDVQQLKISVMSYARKKSSLIERVYEKPQATVFLTSTDSGLCSHTDRGGGSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMY3</accession>
    <name>A0A367LMY3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_2502</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMY3"/>
    <dbReference type="STRING" id="1330021.A0A367LMY3"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF3">
        <property type="entry name" value="POLYAMINE TRANSPORTER TPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="509"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI15760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="530" mass="57233" checksum="F278E320394B8DCB" modified="2018-11-07" version="1">MEDNNNHHRLSADRALATLGYRAELPRNFGMTSILGLSFAIMAVPFGISTTLYITLTNGQAVSVLYGWLLVSLISVCIAASLAEICAVFPTAGGVYYWSAMLSPRPWAPLVSFVDGWLTLVGNWTVTLSINFSGAQLILSAVSIFHPDFVANQWQTVLCFWALMILCALVNAFASRHLGLVNNLCLYWTTATVLIVLVTLLATARHRHDAAFVFAHYDASASGWPEAWSFFIGLLQPAYTLTGYGMVAAMCEEVQNPEREVPRAIVLSVVVAGITGIVYILPLLFVLPDVQMLLQVANSQPIGLLFKTVTGSSAAGFVLLFLILGILLFAGIGALTAASRCTYAFARDGAIPGHRLWSRVNKKLDMPLWALALSTVVDCLLGCIYFGSSAAFNSFTGVATICLSASYGVPVLVSLVRGRKHIRNSPFSLGNFGPLINIICVAWIAFAVVIFCMPVSLPVNASSMNYASIVFAAFALIAVVWYFVYARRNFTGPPVIKADLLDQNVTDGNAAASEASQQQQEQQASQKKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LN34</accession>
    <name>A0A367LN34_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Threonine synthase</fullName>
            <ecNumber evidence="5">4.2.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L249_2563</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-homoserine + H2O = L-threonine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10840"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57590"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="EC" id="4.2.3.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:10841"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the threonine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.1" evidence="5"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LN34"/>
    <dbReference type="STRING" id="1330021.A0A367LN34"/>
    <dbReference type="OrthoDB" id="5203861at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004795">
        <property type="term" value="F:threonine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01560">
        <property type="entry name" value="Thr-synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000046">
        <property type="entry name" value="THR4p Threonine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1380.10:FF:000003">
        <property type="entry name" value="THR4p Threonine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1380.10">
        <property type="entry name" value="Threonine synthase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029144">
        <property type="entry name" value="Thr_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037158">
        <property type="entry name" value="Thr_synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004450">
        <property type="entry name" value="Thr_synthase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051166">
        <property type="entry name" value="Threonine_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00260">
        <property type="entry name" value="thrC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42690">
        <property type="entry name" value="THREONINE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42690:SF1">
        <property type="entry name" value="THREONINE SYNTHASE-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24857">
        <property type="entry name" value="THR4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14821">
        <property type="entry name" value="Thr_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0791">Threonine biosynthesis</keyword>
    <feature type="domain" description="Threonine synthase N-terminal" evidence="14">
        <location>
            <begin position="8"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="13">
        <location>
            <begin position="93"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00050436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR604450-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCI15797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="525" mass="58283" checksum="EB1D955B91A1C5C1" modified="2018-11-07" version="1">MAGSSQSYLSTRGEDDGLSFETVVLKGLAADGGLFLPEEIPLAADWHSWSDLPYAELAFRILSLYISTDEIPANDLKDILKRSYSKFRADHVTPLKHLSNDLWLLELFHGPSYSFKDCALQFLGNLFEYFLVRKNQGKQGRDRHHLTVVGATSGDVLLPSVPTGSAAICGLRGKKDVSVFILHPKGRISPLQEKQMTTVLDANVHNIAVNGTFDDCQDMVKALFADKETNERLKLGAVNSINWARILAQIVYYYHAYFSLVKSSSSFKLGDKVRAVVPTGNFGDILAGYFAKRMGLPIEKLVIATNENDILHRFWKTGRYDKKGTDGQTGGVRETLSPAMDILVSSNFERLLWYLAFEFASTAGMDQQWSRTQASREVTAWLADLKNKGGFGPVYADVLESARRTFESERVTDSETVQTIQKYYRDVDYVLDPHTAVGITAAERSMARTAAMGLPHISLSTAHPAKFAGAVNMALEAEPGFDFSRVLPAELAALVDMETRVSTVDASWQGLRELLTKQVEDDLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LN54</accession>
    <name>A0A367LN54_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_3286</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LN54"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="396"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI15817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="495" mass="54251" checksum="6DA607EEF013F32F" modified="2018-11-07" version="1" fragment="single">MPEFIRSKSRMANLYGKGIKRSTTDIQIFRQGKLCVVRLKISKLTGVHYIYRLITKPNLKSHASPRAVVLTKSNDLFAGPEPSDLASQDEVRRMQVRCSHSIPQEMLVSILATVLSVYCVAVARRWGTTVLVDCVIGEPIRFSSVVLNYITGQTKRWTVDREMEYIKLPIGLLNKEKNHRSHQQASRFPPNVQYQTTMKLQSIAVVGALAGLSVARPTVDNNSRGPSQSSGLPSSSDPSADSAGLPSGPIAKEQVASPSVSGSNSTMVSGAMTKRRTSKRPTPGGSSPPHPSASPHPSASDEELSTPSLEKRSGPSQSPHPAGASSSPDSQDPSGAAPSSSPGAQALYPTLALTLAPSARLAPMAHLARLGLAPPALAPALALSARLAPWPVWASWAVWAVWAFWAFWAFWAVWAFWPVWCPGRESGDSRRRSRRWPRRWPPWPVWPVWPVWPVWPVWPVWPVWPIWPVWAFWPWRLPVAPPALAPALAPMARLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNG3</accession>
    <name>A0A367LNG3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_3310</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNG3"/>
    <dbReference type="STRING" id="1330021.A0A367LNG3"/>
    <dbReference type="OrthoDB" id="434783at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005310">
        <property type="term" value="F:dicarboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006839">
        <property type="term" value="P:mitochondrial transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000034">
        <property type="entry name" value="Mitochondrial 2-oxodicarboxylate carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051752">
        <property type="entry name" value="Mito_2-oxodicarb_carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46356:SF1">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="7"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="107"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="202"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI15792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="32907" checksum="BAD9E8656043DA41" modified="2018-11-07" version="1">MSQEKPLPFRYQFAAGAVAGVSEILVMYPLDVVKTRVQLQTGKGSGAEAYNGMLDCFRKIIRQEGFSRLYRGISAPILMEAPKRATKFAANDEWGKAYRRMFGMQSMTQSLSVLTGASAGATESFVVVPFELVKIRLQDKASAGRYNGMVDCVVKTVRNEGPLALYQGLESTMWRHVLWNAGYFGCIFQVRQMMPTAETKQGRLFNDLVSGSVGGTVGTMLNTPMDVVKSRIQNTPRTAATSPKYNWAWPSVLTVLKEEGPAALYKGFLPKVLRLGPGGGILLVVYTTVMDTFRKWQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNJ3</accession>
    <name>A0A367LNJ3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_3326</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNJ3"/>
    <dbReference type="STRING" id="1330021.A0A367LNJ3"/>
    <dbReference type="OrthoDB" id="343296at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000003">
        <property type="entry name" value="Calmodulin A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050145">
        <property type="entry name" value="Centrin_CML-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23050">
        <property type="entry name" value="CALCIUM BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="53"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="138"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="176"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI16005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="209" mass="23991" checksum="D1325238CAFEF453" modified="2018-11-07" version="1">MNSHSASRPFALRSAAGGSSQQQPQVQQRPAQAQAPPPPQVSSNEDYSAIADEDREHIDEVFDLMDMKKKGWLNSYEFRHALAALGFDLPKPLYFQELESHGSVPPEWRDPHSCPVNRLYMYLDQFRLCAAKLISNRDPREEATKVFNMFDYDQDGIISFDDMRRLAQEIKDDRVMTDEEIQSMIEYLDHDGKGGVNLEEFIQMMEEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNP1</accession>
    <name>A0A367LNP1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_1744</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNP1"/>
    <dbReference type="STRING" id="1330021.A0A367LNP1"/>
    <dbReference type="OrthoDB" id="674948at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI16001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="113" mass="13191" checksum="9310A8BB4B9E9D6D" modified="2018-11-07" version="1">MDATMEALRLVSEGCDERAGSWRFETRGSRGVSDSLTQCLRDFGQPSREVLLTLLWVLRLEEHKIQRDEEQKFRSGNNILKEKSTQKYVLKVKEMGKGNNDRPVAFDQYRRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LP04</accession>
    <name>A0A367LP04_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_3243</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LP04"/>
    <dbReference type="STRING" id="1330021.A0A367LP04"/>
    <dbReference type="OrthoDB" id="2414662at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016212">
        <property type="term" value="F:kynurenine-oxoglutarate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000024">
        <property type="entry name" value="Kynurenine--oxoglutarate transaminase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051326">
        <property type="entry name" value="Kynurenine-oxoglutarate_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43807:SF20">
        <property type="entry name" value="FI04487P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="6">
        <location>
            <begin position="51"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI16175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="439" mass="49654" checksum="01A198A646C04758" modified="2018-11-07" version="1">MRARPWRQILRHRLYNTMSKTIQPAARVSGQKQDVWSIINEAAAASPKQPIVNMGQGFFGYNPPDFILDAAKKALDRVECNQYSPTKGRPRLRKAIAEAYSPFWGRAIDPETEVTITTGANEGMLSAFMAFIEPGDEVIIMEPYFDQYISNIEMAGGTIVYVPLHPPATGATHTSSAADWTIDFDELQRAFTPRTKMIVLNTPHNPVGKVFSKDELRRIGDLCVQNQVLILSDEVYDRLYYVPFTRMATLSPDIERLTLTVGSAGKNFYATGWRVGWLMGPPELIRHVSTAHTRICYSSVSPLQEACAVGFEQAEAKGFWKQTVADMRAKMNLFNGVWRELGLPYSEPEGGYFVLVNMRRVRIPDDYPFPAQVADRPRDFKLAWFLIQEVGVAAIPPTEFYTDANAHVAEDYVRFAVCKEDNVLEEAMERLRGLKKYME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LP70</accession>
    <name>A0A367LP70_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_3145</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LP70"/>
    <dbReference type="STRING" id="1330021.A0A367LP70"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="4">
        <location>
            <begin position="545"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI16233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1034" mass="113478" checksum="FEA1105550841712" modified="2018-11-07" version="1">MINYFTCTLGHGHRRRQQGLDNATPFRTVLHLIDEQARHAPSALALGFASPTPESLTFDELRLRSNGAAGTLASCVGPPPADAESRPRSVGLLCVSSLDFVLTWLGLMRLGWSVLLLAPQLDAPAARHLCTALGIDVVLADDANVEGARRIRNGVRAVAIPSYDAAAPEAGGCCPTLSSSDTAYFFHSSGTSSGLPKPICQTHLSAAGALPRFPVQSEMEATFTTTPLYHGGLADAMRSWTAGAPIWLFPERLMPITAANVVRAVNVARSRSAVGYFSSVPYVLQRLAEHRQALELLRSMAVVAFGGAALPVSVGDGLVDAGVKLSSRFGSAECGFLMSSHRDYSVDREWQYLRPVYDPHLLTFEPRDDDLCELVVRPGWPVRAKTNRPDGSYATSDLFQPHPWRPNTWRYHSRADSQIVLLNGKKFDPAPMEADILASTTSLLRDVLIFGTGKDYPGILLFPAADTEAGADVANLIWPVIDTMNAATASHSRLIRPMLIPIRDELPLDKSSKGSILRRQAEERYAQAIESAYHVTGPSSSSSLDTHEQLLPTVLSCFQQVLGRHIDPHEQLFRQGVDSIASIQIRNLLQSCAITEKKLPVTILYDKGTVDRLVVYLERLRNDDEHDDGEEEKELDTMQHLADKYSDFSRLQVTPREKKAVCITLTGATGFLGAHVLKQLLHNTKVMRVYCLVRASTQQTARGRVSSSLSTLGLGTLDDAKVGCIPYDISSTGLGLEETHRQLLLRETTAIVHLAWAVNFSFPLGSFEHHIAGTRELISMAVESCSRFFFISSTAAVSLCASTPVPERLSERAADASPLGYARSKWVTERVCAAASEHLYRLGLAGCVSIIRVGQLCGDEAGVWNASEAYPLMLSTASLAGCLPHLPRERLDWLPVELAARAVMEICLPTTATPETTRSEATRVYHVVNPSTCPPTWRQLLEWLSQDSVGPSFDIVPPETWLLRLEQALKDGETNHPAEALLELWKDSYCRDKGACPQFSVEQSQRVSATMGAVEPLDRERLIRIWRWICQTRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQC0</accession>
    <name>A0A367LQC0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GTPase-activating protein GYP5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_2231</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the GYP5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQC0"/>
    <dbReference type="STRING" id="1330021.A0A367LQC0"/>
    <dbReference type="OrthoDB" id="295078at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000044">
        <property type="entry name" value="GTPase-activating protein GYP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23436">
        <property type="entry name" value="RabGap-TBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="3" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="12">
        <location>
            <begin position="363"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="43"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="395"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="735"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="46"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="189"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="219"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="239"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="405"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00072088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI16609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="870" mass="96453" checksum="F4461A23E427AC10" modified="2018-11-07" version="1">MEEPIVSRPASAAEANHDTHFKAFEHESFEDAVDAVDAADLHDTVSVRSLTKRTVSVSQSPASDESDDTDNSGENDEEVHKARDAEQDLSKARPPSSRQSPAPSSHISSTPNLDNVNLDDEAPPKHRESQSSVEKDQPTKKLSLGSIAGALPSMPWNPPTEPSPKSEPPSKGNALITASSHPPPPPTRKLTSPFSWLSRSANTKEKDSQTSPPTLPSPRRNTASSVATLMSNPEMMLSRLEEEREGDGHGSNRESLKDRFKALRLREESGISPQEAHGDKAGGELGLAHQDEDYAAGEVPPPSPVPGPNNELAPGTMSGINAGPSAMPDTRVDWDLWQSVVYEGPTAVARSSPEELNRAIATGIPNAIRGVVWQVLAQSKSDGLEVVYRELVARGTEKDRDRHSNSTTASSISNASLSAHSGDAPTSSASSVHSDQSAANGASSPKGDKGADVVVKVTAVSPQERKRKTKENAAALSKLEKTIRRDLGARTSYSKYAAAAGLQEGLFGVCKAYALYDEAVGYAQGMNFLIMPLLFNMPEQEAFCLLVRLMNHYHLRELFIQDMPGLHMHLYQFERLLEDIEPALYCHLHRRGISPHLYATQWFLTLFAYRFPLQLVLRIYDLILSEGLSAILRFGIVLMQKNSATLLGISDMQQLTTHLKDKVFDVYIDKDPSQGSILENGFFGSSSSSLDKEVYRADQLVRDACEVKMTPEMLKAYTTEWEEKTKAERSREAELQELNLANQSYAIQLRKLEERVEACDREQTALATEMVHTKVENEELRDENESLKGQVRELKVVIEKQPAQIEASWKLERDDLMKRNGHVHEENQRLEKELAELEEELVQTKMQYAEINSQHETLMRKWSDLKRQFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQY5</accession>
    <name>A0A367LQY5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L249_1771</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQY5"/>
    <dbReference type="STRING" id="1330021.A0A367LQY5"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF3">
        <property type="entry name" value="REDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="279"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="15">
        <location>
            <begin position="353"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="535"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="333"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="549"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCI16864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="626" mass="69488" checksum="5D14FC3B173C8A7B" modified="2018-11-07" version="1">MLRPRHIQNHSDAAAHEPHWGYPDRAIPCTNDAGSCAYLDVVYEAHDRGMLYVGIIWATVCALLSICFLLRLLHRPVGFVTPPPAIRARTRLCAALASLRRRLFLPVAARPLFGRGSRMQVFVLACLAGYLILWTFVGIAYRKWITPVKGQPGLFNTRTSLGPWSDRVGVIAYALTPLSILLSSRESMLSVLTGLPYQTFSFLHRWLGYIIFLQGALHTIGWFVIQFRLYQPQPSAGLKWIKETYIVWGLVAMMLLCLLFLLSTPWAIRRTGYEFFRKAHYVLAMVYIGACWGHWDKLSCFLIPSFIFWGLDRAARLARTALLHYHPWGGKASSSSSSSSSSSSSSSSKGVGFRPATASLSIFKEPSGGEVVRLDLDNDQDVWAVGQHYYMCFPHCSFWQSHPFTPLNVPVLRNGTVRHSYIIRSRGGETQKLAKLAASQASTPVLLTGPYGEDLVSRVGASNIICVAGGTGISYVMPLLLQLQQHQTMADRRIELVWAVRHLGNVEWVREEIDALQKTPNLTVRLFATRDGKAEKGTVSASSSDDDGMSVHKTGDDSHRHPDLGRIVNDFVESTVSGPTAIVASGPGSVIADLRAIAAALNSPSKVWKGQERFDVDLICDDRMEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LS88</accession>
    <name>A0A367LS88_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_2617</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LS88"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI17316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="64" mass="7796" checksum="F00C0C50C2149B95" modified="2018-11-07" version="1">MSSQLKPTKREKKATWNSLFISRAHHLAYMDCRCQRSTGWKEISIHHILFIFYRYRYTETVSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LS98</accession>
    <name>A0A367LS98_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ACB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_2348</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LS98"/>
    <dbReference type="STRING" id="1330021.A0A367LS98"/>
    <dbReference type="OrthoDB" id="346910at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF133">
        <property type="entry name" value="COA BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="ACB" evidence="3">
        <location>
            <begin position="5"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI17112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="285" mass="32562" checksum="1B8F1A9C26A20681" modified="2018-11-07" version="1">MADSVDRVFVHALNTVKKIPKTGASRPPQSDRLRLYGLYKQAMEGDVDGVMEQPAPSPGLTAEELQREQDKWHAWNSQKGLSGTEAKRRYVEALIETMHRYATTKDATELVSELEFVWNQIRHNSSGSSDYSPRTAAARLHQQQAASSAEGPMKVLTPMSEQGEAEMRSHRRRMELLDDAAADGERSGRWQRTMDRAVTNLSAEVAALREQIATGREWKSKKKRSFSAWLRWMAWKVIKHLIADCIVLAIVLLWLRRRRDTRLEDLVRAALKLGREYARKVLPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LSN1</accession>
    <name>A0A367LSN1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED6</name>
        <name evidence="10" type="ORF">L249_2090</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LSN1"/>
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    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="F:transcription coregulator activity"/>
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    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.580">
        <property type="entry name" value="Mediator complex, subunit Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007018">
        <property type="entry name" value="Mediator_Med6"/>
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    <dbReference type="InterPro" id="IPR038566">
        <property type="entry name" value="Mediator_Med6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13104">
        <property type="entry name" value="MED-6-RELATED"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="172"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="238"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI17397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="349" mass="38187" checksum="8BC5331A602DDF8E" modified="2018-11-07" version="1">MANPNDPPLSEIQWRSPPILAHMGGLHSNTILFYFAESPFFERTSNNAVIMSQAMNNVSMYHFIQTREAFEGRLKTMSGLEFVVGEEPAETGPGMGTGVWVIRKQTRRKRYPEDDEITIHASFFVVGENIYMAPCLSDILASRIMTISSAISKALSAAEGARKWSASTGHLYHIPSTQNTTRRKLSSDGDTPTGPDTPAKATATTTTTATAPQKANELSLERASEEAFLTHMRHGGEYIDENPITGRPGEFHLSSTGRKAVPPPKLNAGSAMGAMNGPTLDTKVEEKKDAKTEKSPNLTDEERRSPAIALGLLVYYEPVSSDYGAMLQLSTSYEDNIPPPSTKIHRDKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZ02</accession>
    <name>A0A367KZ02_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MHYT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_1364</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000031">
        <property type="protein sequence ID" value="RCI07398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1330021.A0A367KZ02"/>
    <dbReference type="OrthoDB" id="264015at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005330">
        <property type="entry name" value="MHYT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35152">
        <property type="entry name" value="DOMAIN SIGNALLING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G11310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35152:SF1">
        <property type="entry name" value="DOMAIN SIGNALLING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G11310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03707">
        <property type="entry name" value="MHYT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50924">
        <property type="entry name" value="MHYT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="235"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="MHYT" evidence="3">
        <location>
            <begin position="20"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="679"/>
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        </location>
    </feature>
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        <location>
            <begin position="823"/>
            <end position="861"/>
        </location>
    </feature>
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        <location>
            <begin position="427"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
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            <begin position="679"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI07398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="891" mass="97832" checksum="7971DDC28FB727E4" modified="2018-11-07" version="1">MASAQELLREFEGKIVPFKFEAGYIVVSYIICFVGASSALELIRRQTSNKGIHNLLLLAGAAISMGGIAMWSMHYVGYRAVHFLHGQHEFEFVFKTGLAVAALFIPIVVLFVAFVIITRHGRVCWIRITMAGFLSGATLVGMHYLADASISNYKPVYRAGYIVGAALIGVITNIAALAFLFVFESAWTNAWWKRPLCALILAAAISAENWCAAAGTKFKLLPPHHTGPTFSLRGAIIVVICLTVGGCVFTIISALYSYWIKKDYAKKAQKVALAAAVFDDRGRIMVSHEGLLPSEVVTDTFIPTTNNDAFDTSNPVFHWMFWASRNWPRIAHVLGGMEDHVTSLSTKSKRKLKLKLLRDDGEAVENYNTILCELYCLAAASLSTRMKDDLESSGTLWDEIFATGDISSSSNRISANYTGGSELPLYRSSTSSFTKPQSNGSGEKNYESSEEGHGKGSLMFLVRHVSSRREVEKLEAAGFRFAELHRVLGTIRTGMQIKTPDFAARLRIMSNFTEQDADLRPGVHVGLFAVRARVDFGGFDVLVQRKAKNLLPAIHLQKETLRPWQKEILKRLQGMTTPEIIQNLDIDRFESARERHFARQLLESITSLRSLIDQPVFDEARLNTSVFQVPCSSIDKSATCSVLAFQLVLPIHTKISFRNCEAIPLQFFKIRQFFSQGFTGPGRTPTGGVEQNDLHFPPSSSTLGPATAGPSSFMEFVRPGRPFRKNVPHPASHHALAQSLRALTAITRNNNVNGQAATPGGDANARNGDTQPLAAAMAPAGQSDGRHGGSILVSQEVVIDYQQDSSSDEDDDMDELDNMEKATIESSSGPQSAPVAANRHYRPNLSPAPEEESYSVTATGRDIAGATKDQASFVDELLQSCMEKYKPNSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZU2</accession>
    <name>A0A367KZU2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_5713</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000024">
        <property type="protein sequence ID" value="RCI07713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZU2"/>
    <dbReference type="STRING" id="1330021.A0A367KZU2"/>
    <dbReference type="OrthoDB" id="1717591at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072318">
        <property type="term" value="P:clathrin coat disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000002">
        <property type="entry name" value="putative tyrosine-protein phosphatase auxilin isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000354">
        <property type="entry name" value="UBA domain-containing protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172">
        <property type="entry name" value="AUXILIN/CYCLIN G-ASSOCIATED KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172:SF19">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="3">
        <location>
            <begin position="245"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="199"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="266"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="336"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="662"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="686"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="353"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="410"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="476"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI07713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="808" mass="87639" checksum="E631EA43FECA1BBD" modified="2018-11-07" version="1">MDDLSGLDWSKPAAAPPKQQPPKPRPPPNQPMASLQPKPSAASFLPAKPAQQKDSFSNLVSFGPNKASQNLSLAERQAQLEAEKRKRDEERRKVSEAQFGSGLQWDALGSRAFTPSPNLQPPAAAADEDDLFAAFNKDTKVDNASHYPPPSSERSISSDGRQLNLRDPKAWKPITAEDDDDPFGLNELKSCTAAPVIATDEDDFLGDLAKPVDEVRRKRQEAARPEPGKPIEPDDTSSSEEDVRQSDDALDRAVAQLVDYGFSPADAMRGLKHSGGGSANPQAAANWLLDEAHRNAERKSQGRSASAGPKNEADFTRSAAAVGNSFFKTANSLWKTGQKKMQQAVADFQQEGDTGRPRWMRDAHQEQRTSAGDARATDEALALESGGRPAPVHADRKAMPQHNSGRGTWSTPSSGSQSRSSPVPRWQQQAPPPAVSDARSRLNRLAADDDSDSFSGHVRRRKPEKQADLMLDTTEAPQPVRTAAAQRPARAQIHNNSPPKMAPPRRVPPINPAALQASTRHRIQGTAHFKRGDFAMAHSSYSSSMAGVPATHPLMIVLLTNRALTALKTGEPKQAVSDTDEALKLIGPGRGRDETVAVRGEGGQEETKPLTELYGKALSRKAEALEQMEKWADAGAVWHLCVEAGVGGPTAVKGRQRCQEALAPKKKPATTTAVKRPPRTSAPAKTSAAVERLREANQAAAREEDEKFALAEQVDSRISAWRDGKRDNLRALLGSLDKVLWANSGWKTVGMHELVMANRVKVVYMKAIAKTHPDKLPQDASTEVRLVAGLVFSTLNESWDRFKADNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZW0</accession>
    <name>A0A367KZW0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">p-aminobenzoic acid synthase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Para-aminobenzoate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">L249_5714</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>chorismate + L-glutamine = 4-amino-4-deoxychorismate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:11672"/>
            <dbReference type="ChEBI" id="CHEBI:29748"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58406"/>
            <dbReference type="EC" id="2.6.1.85"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 4-aminobenzoate from chorismate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000024">
        <property type="protein sequence ID" value="RCI07706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367KZW0"/>
    <dbReference type="OrthoDB" id="27962at2759"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00149"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046820">
        <property type="term" value="F:4-amino-4-deoxychorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01743">
        <property type="entry name" value="GATase1_Anthranilate_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.120.10">
        <property type="entry name" value="Anthranilate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005801">
        <property type="entry name" value="ADC_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006805">
        <property type="entry name" value="Anth_synth_I_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015890">
        <property type="entry name" value="Chorismate_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058565">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058567">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058568">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058564">
        <property type="entry name" value="TPR_TRAPPC9_Trs120"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006221">
        <property type="entry name" value="TrpG/PapA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013935">
        <property type="entry name" value="Trs120_TRAPPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058563">
        <property type="entry name" value="Trs120_TRAPPC9_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21512:SF5">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04715">
        <property type="entry name" value="Anth_synt_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00425">
        <property type="entry name" value="Chorismate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26254">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26280">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26282">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26283">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26251">
        <property type="entry name" value="TPR_TRAPPC9-Trs120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08626">
        <property type="entry name" value="TRAPPC9-Trs120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56322">
        <property type="entry name" value="ADC synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="5" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trs120/TRAPPC9 N-terminal" evidence="13">
        <location>
            <begin position="453"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 TPR region" evidence="14">
        <location>
            <begin position="876"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 first Ig-like" evidence="15">
        <location>
            <begin position="1191"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 third Ig-like" evidence="16">
        <location>
            <begin position="1526"/>
            <end position="1684"/>
        </location>
    </feature>
    <feature type="domain" description="Trs120/TRAPPC9 fourth Ig-like" evidence="17">
        <location>
            <begin position="1688"/>
            <end position="1790"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase" evidence="10">
        <location>
            <begin position="1876"/>
            <end position="2085"/>
        </location>
    </feature>
    <feature type="domain" description="Anthranilate synthase component I N-terminal" evidence="12">
        <location>
            <begin position="2182"/>
            <end position="2332"/>
        </location>
    </feature>
    <feature type="domain" description="Chorismate-utilising enzyme C-terminal" evidence="11">
        <location>
            <begin position="2514"/>
            <end position="2742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="277"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="386"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="658"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="704"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="844"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1200"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="2456"/>
            <end position="2482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="279"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="846"/>
            <end position="855"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF26251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF26254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF26282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF26283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RCI07706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="2754" mass="301492" checksum="3EA7A9ACBD7DFF66" modified="2018-11-07" version="1">MAEAETEAATQNAPRTWLLTAALSPLAVRLIRRLLSHGDHVVACLPPHEMDDEERSAEFRQLISECKAGGGDRYGWRDRIRGIRCDGRMSSCGAAVAEAVQVFGRIDILLCCRSEAVVGTVEELSTTPLTQNLIRDQFEAIFFTQVNFIKATLPTLRSQHTGHIIILSSIGGHIGTPGMSMYTAATWALEGFCDSLAYEIAPFNLKLTIVQPNKEIQSLTNRLIFAPQMPAYADIFHNAPSIREMLIDVLNANPETAMPLEPMLIDVLNANPETAMPLEPVPSEPFPPQQAPATPDSSSLEPEAVPGGQILYRYPRLPPFAADRLVAETIHALTAIGGHENPPSRHIVGFEGALAVKEKLKTVTEEMEDFVDASLAVDIFDSVLKEEASRRGPPEPEPEPGPGFGARSEPGPQAFALHTSPLRFVPPPTRNPRALAPWSAVDSRDARMNLDPLLPIAPARVRVLLLPLGRLKAVNFASYAERLQTEHVVCLRDVSADGRPDRNMFSPLAFPDGTIFYHLITHMLPPSHLALWPFDIYREPLVILALADGEELQNATSSSTHPESSVQALEEELEKLRESHPKALVHRVIVFDHVASETDTPLPDGVVSVPPVEDCKRTTLKTVMCDVSSLLLAEMTTLAKSFEGISVIESPGQAAAASRHIEGNAASSTTARRNSHFSLPHHEPRPNSAAGLENVRQARMSMPPMASIRPPINSTSSLPARPSTPVKGGLPSIPMSPDDADAGSLSSPEQKRDGDRVSVQGFGVGSPNDRWRQRGKGRTSVVIGSLYLQGGRWIESLKELCEAASTARSLNDHVWHGKALELIVIDLLLLAWAGMSFQVPAVCQPPQEQSSSNGSILKGEKDANPKAQQPLHIRQLQALLPELLDRIIALYSKVSSESLPPLPQSEAIIRFSRILLAIHLAGGRLDTTALDIIVRGTPPPQRLTTSPRLNVVPARQHIVGLLFKAFPSSATELLTTTDRASVLCGMAAVLGSLGYHRKRAMVMRELVSVLIGGLVEARTRGAADAGVHPAAGLVSLTSGHDGAMALDLGEGDTEFGLEALLEHLCSSYGIVGFKSKSGDDDDSDNATVARILDQSWARFFGLTGVKLNILRACINFSEALPDFEGVLKFSSDLLRTGGSGVAPGPRREDATPLIHKDEQVRLATNVSRTASLVQRLGMGHLTAEYWDEFLVRGITLEPPPEARTPVPHARSDLPGGDTSEVRSSQGVNPFIYNPFLKEPDEVVEQHLVAGEVATFRVRLQNTYDIEVDIESVRLCTEGVDFESWPERLTLGPYRTQLVRIRGRPREAGSIRLTGAMVKVCGCRERRFLIFAKSWAPPPQEKIKVRGTAALEAAVGGGEKAPPPEATTVSFNVIAAQPLVAVRSTTLPQSAVMILEGERQRFSVTMANVSAVPVDLMLFSFKDATQAPLQEALGRRDATPAELYEYELILSKRQALRLVGGNNDQDRSIAAGGEATFEFVILGKPGLTSATIQVDYTYLGTRRDEVKDRFFTRRASLDLRVTVNASVELTRVDALSLEGEMPAPLRNRLGSGLPARADEYCLLCVDLRNAWPSLMAVRLEGDDGLAAEEDVLPGKTSRLVLPVKRIHIEGAHEPIPSLNPSRGRQFVVSASKISPDAERTSRETFWFRERLLERVTATWRTTTGRNGAIELRNMRLTSRMIEALRVDEVEIEVTVDEATTTAYVDDFLTLTVRLTNRTATTIFPLVRLLPALRHRPLNVALDQTRKFAWNGTLQQLLRPLPGHGSISFSLGVTALCRGEFELGVSVEEVQTTYFREGSGYFRGTLISCCLPLTERTIAKRLGAPLFLSLHRLLPPSGPNQGHVSAHSTLESPANVGSEASVATMTVPKTMPPRRILFLDAYDSFTNNIVSLLKDVLGSQVTVHVLHMDLKTLDSDPSPDWTPGQFSERLSAFDAVVCGPGPGSPVHDADVGVFKMLWENHTVPVLGICLGFQSLVVHFGGGIRRLRCGGLHGLVHVVEPVDGADIFRDVPAFGATLYHSLCADVGQDHIAEGDWPAARRSRPCCAPDLVPLAWTHHADERILMAVRHASRPFWGIQYHPESIRTAAVAHDVVRNWFRAALESNQGLRPKVDSFTCVDSLSPSVCALNAAQLRPAACPWRDDMQSGLAAEAVSRPRYSCRRVAMPKGTNAADVAELLGLDVSREAVILDSSSAVRGDPRAKNSIIALAVDEALRLEYHVGDDYLSLRLPAARGRDERRQRIRLGLDRDGNIDPRSPWHIMSELWRRWRRRRRRREWIPEAGDNPVFKGGFLGFVTYEMGLSTLSPGLVPRNRAHKRPDVCMAWVKRSVVLDHEACVAYVQSLDEDDGGWMDGVVEVLEREARHGTDGEDAATFVDNDQLLRDIRSGGRLRFDVPEAEAYEKLVRRCQEKIREGESYELCLTAQTTVRPGGCGEHGRLDIGDVGGCDYLMDGNNHRRDDIDNHHHDRNNHNQNHDEGRNHSCNGTDKDGDGDGNCNGNKHQNNHNGIDQHNDKWSKTAWQIYRTLRGRQPAPFGSFVRLGGATIIGSSPERFLQHGDDGVCLMRPMKGTVRKSPSVSTLDQAEALLHVPKEEAENVMIVDLVRHDLSGVCGAGRVTVTDLLRVEEFVGVFQMSTDVRGVLPGSGNKLSERTTTGFDVLAATLPPGSMTGAPKKRSCEILASLEASERSLYSGVVGYLDVDGRADWSVTIRTIFRWEGEDVWRIGAGGAVTGLSAAEAEREEMFVKLCGPLRVLRDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0A7</accession>
    <name>A0A367L0A7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000023">
        <property type="protein sequence ID" value="RCI07841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0A7"/>
    <dbReference type="STRING" id="1330021.A0A367L0A7"/>
    <dbReference type="OrthoDB" id="5396252at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42068">
        <property type="entry name" value="YALI0B18964P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42068:SF1">
        <property type="entry name" value="YALI0B18964P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="842"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="849"/>
            <end position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI07841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="901" mass="97277" checksum="050A3D093280B8E0" modified="2018-11-07" version="1">MPRFSFAFSRRKPSADDFENVHITTTAEQPSFRVFERPDTSNRSFDGGARLARVPRTALPRPDLPRPNLVELDADDNMFADLKVNRGSGLSNTTKATSTDNSSRYSNASTAPSSADLAGHESQPPPRESPSRTESKSNSFLDRATRTFSFGVQKKHTVPPPKESIVPDLPPVLSLSGDTSTTTTTTTTTTTSSENRSRGLTCSTDSTATPTQPHPAAGINLGGDFSSILTSFEEKQPNDAIDPRFPAGIRQVSALDPGVAIVSPARGGLSHQSHENKPSTFSTQQRLGSRYPEPDPVSRQQVLGSRYPEPEPPKKVVVVDEDAKFLQESLAAINLFSDPHASASSPAQAHRYRRDEDTFHATPTKTVAPKEDNIFEGSLSRASRVSHRYVPRTTYQHNKNKVMTPAEFEKYRQDKEKQGSKQQAATEAVKEDEDDINYEDDEDELEQSKQQAKQRRKQEAHMAVYRQQMMKVTGESAASPPVQRNPRAGLPPSSSAPQLSTKSVSGVEDEDEDEDVPLGILQAHGFPARNRPPTRLAHSGSSTNLRSSPQGPPAGRPASITGEAPSNAARRQSVLPAFARNLPQDPFVGASIARPALRESLSFGDAGQFAQLQQQQQQGPLPPGGLVGVIASEERSRALRRGSPSVDNMKLPMGMGPSGPHAPGLDPVGGIPPHMMYGPGSMPGMASMPPPQPPAMMPGDQAQLHMTQQMQQFMQMQMHMMHMMAANQGGGGGAGGHPMQPQMQPPYGGGLPSSMSVADLSSRHSVISDPARAMSMLHGNTPFLQQPPQDGYLSAAGYAPSIAPSERSNIGLPGRYRPVSQMPPGPSMPAVAQGHQRSATMSGRLSSWGDDKSRSTVRVVDRAGEGSDEDDEQGWAAMKALRERKKSMWKTKKSYGSELAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0D5</accession>
    <name>A0A367L0D5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000023">
        <property type="protein sequence ID" value="RCI07876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0D5"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI07876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="127" mass="14844" checksum="6D4FD8E1791FEEB6" modified="2018-11-07" version="1">MGDAGRERSRSNFLSTLLRRRSGKHIIYIHQIGRYQRGRSRCFTSQHSKRGSITRIIQTNFFTDKESSETEAEPKKDSIIFHCGPSHTSQIRAPTFNAVRRTERRCRGGNGGRRHKERRKKRTRNTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0I6</accession>
    <name>A0A367L0I6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="2">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_5861</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="2"/>
    <dbReference type="EMBL" id="LKCN02000023">
        <property type="protein sequence ID" value="RCI07926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367L0I6"/>
    <dbReference type="OrthoDB" id="10264149at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05167">
        <property type="entry name" value="PI4Kc_III_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.70:FF:000011">
        <property type="entry name" value="Phosphatidylinositol 4-kinase alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000022">
        <property type="entry name" value="Phosphatidylinositol 4-kinase stt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045495">
        <property type="entry name" value="PI4K_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF15">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19274">
        <property type="entry name" value="PI4K_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIK helical" evidence="7">
        <location>
            <begin position="1377"/>
            <end position="1552"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="6">
        <location>
            <begin position="1685"/>
            <end position="1952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1652"/>
            <end position="1679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1658"/>
            <end position="1673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI07926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1968" mass="217617" checksum="4F30908A5156758D" modified="2018-11-07" version="1">MMRDLRAQAIEKIALLSAAASAPSLDRSDIDQLCRACHSAGRGREMAHGGSGAKSPGSLGRAPMSIREFEILLALCKSAPRIQSSQSAQRLSYLLLPYILDSHSQAFAPSPFFRRVQPSATESLALHVTGALLALGSNFIDLRETVADGILAFTNSCSKAVEKVVLQVSDLENPCMEDSVRAVTISLAILGFLDAASTQADFWKVGSRLSLIQRFRHILSEPFLVALETSLSTIRNSHSQAREAKEWRRLARHYASSGRPLGAMLLQRSFMWLVLSNTALMVADGPTLRGSHILDLLMSEGRKLQAEPDHLIDSDLRSVELCAGLAVEHMDYIEAGTDFIRLGSPNQQRLAYATKSAAMISFLNCALVNDELADPDILMTWLQETLDDRIQMADSALASVVLRCFALICRVAPVLSSIVSRVLPRFIVQATPDGDTVGVASMSLAYVLKTLSKDAVISTLYTLGNVLSPVSGGIATNGQTNGAAGTEAVSDPVYAGRHSTGSSISLLRTNGEEETAIVYGNVVQAICGIASACKDEKITALAQSMLLQKVDKVNAEVGAHVISGAGALALNGGQLEFRALLKMYSRICHMGVAERRYPLLTAVMKARTHISANLRRDSPLFDIYWEHLLDSIVSLGDVESSSHTKESDVQLVALEIGELLRPLAVLMASNDFASKPIVGDEARSLLRDAWFNIVVHGFTTTTDRGKRYSSELHTIAVHSPPLIADERSEQVESDIELNTVLRRGHSNEREAGQKKLLSELIPSKAADIKSLSYRKVIFLQAAYLVESLRADSGDCTKVLSYFLEPSMRKGDVSSTMEGITLAVVDQYLSKTLGGADPAFSAHYAATQLATVFCRCCHRIERVQQAAFQCADRIVREVPSALCYRTSLFALLELLSLMWASCLEAETDPYTPRSIFTSDLGNVTLELSDDFNHRRWTLDVLNRKAKAWVGTVVNLAPLDVKGLLQTYLSEFDDEGAYGHVSLGRSFALELGSMMPSTDSRLQSLDRIGDCDINTASDLIAQYTTRQEYRYGETLPDRGVVPVMDKSGPSAAHSTAAESSNASTALAHVEARILSMKATPLTEVRDILRRAAALLCRSSRDEAAVARHLVSIPFSLFTKQSIKLGVSLWLGVINENPRLEPKLLNGIAQQWELTISRKVGLFDPALAHPDPFFEKEEFAPSDLEALARRRQAVHDMLSPHKRLLQFFSSHYNATRLSSTDTQRVFLRMLDLTMNALKKLTSHPMTRELHFQIVLFGLEVLRSSTTLGAGAQWRLKRKILAAGLAWFKNAPRWSFGCNILQLRTEVRLISDVLDALKAVSFIGVRAVGNIQSLQAREQLLQLLLENEQSRLSVWIAPLEHRHAHLSLHGGSKSSLETALTSLVRTAWCEDAAIAMELTTRFHLPRLHRDVRQLLMSAPERAVSQPEALPLMFGGHLADDVDWQLKYLLYWEAANPLTAVTMFLPEYKDQPFIIQYAMRALESHSVDVTFFYVPQIVQTLRYDSLGYVERFIVETAQFSQLFAHQIIWNMKANSYKDDDAQVPDEIKPTLDRVMEKMVDSFAADDREFYQREFAFFDEVTSISGKLKPLIKRSKPEKKQKIEEELRKINVEVGVYLPSNPDGVVIGIDRKSGKPLQSHAKAPYMATFRIRRTKAEVKAPASTTATTTTTTTTTTTTANGGGSGSVVINGSNKNVISQGQEQAAEASTTTTTEVWQSAIFKVGDDCRQDVLALQMIAAFRGIFHSVGLDVYVFPYRVTATAPGCGVIDVLPNSISRDMLGREAVNGLYDYFVSKYGNEDSLLFQRARNNFVKSMAAYSVISFLLQFKDRHNGNIMIDDAGHILHIDFGFCFDIAPGGIKFERAPFKLTSEMVAVMGGSADHQSFRCFEELCVRAFLASRLHCRDLSHIVRLMADSGLPCFRPETVRHFRERFVLDKGEREAAEFMKDLIRKSYSSYSTGIYDQFQLLTNGIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0L5</accession>
    <name>A0A367L0L5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7874</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000022">
        <property type="protein sequence ID" value="RCI07968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0L5"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI07968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="117" mass="12950" checksum="BD5574A610ED398E" modified="2018-11-07" version="1">MGKDAGCLKKPSSIARVLYTEVRIKRYNPSRVLFNTTCISESCYFTSSIKAVLQQRAMSTYLSTYPGMAEACGTARLGKDGKVTMRRLTSDAFPSLLVFNEGLLPQFLCLDLPNIDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0M7</accession>
    <name>A0A367L0M7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleolar complex protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_7852</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000022">
        <property type="protein sequence ID" value="RCI07957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0M7"/>
    <dbReference type="STRING" id="1330021.A0A367L0M7"/>
    <dbReference type="OrthoDB" id="10266662at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030690">
        <property type="term" value="C:Noc1p-Noc2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030691">
        <property type="term" value="C:Noc2p-Noc3p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005343">
        <property type="entry name" value="Noc2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687">
        <property type="entry name" value="NUCLEOLAR COMPLEX 2 AND RAD4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687:SF4">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03715">
        <property type="entry name" value="Noc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="723"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="32"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="73"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="170"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="723"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="758"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI07957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="797" mass="89518" checksum="3518812B9BCDF812" modified="2018-11-07" version="1">MGAAKKNLKATKKFEKKHLRGVLDKRKETAKIKQRLQIKEKKKTRRVKDSDFYKGPKKDEEHGKSGKANGSEASRKLNEMSVDEFFKGGFDDFIDGKALKPRKRKRGEPAKQDAETGDESASSIIEQPVASDSDADENEEDDDIGMSKETMDALADKDPEFHQFLKENDPEALDFDQDADLAEVDELSAGEEESDGAEEKKPKKKRKKAKATSTDADDEEDDRLTRAMVDSWSKALVDKKSLRAARQVVLAFRCAAHLNEQDGDEEKKPRWTIDSPDVFNGIVILALKEIPVVMNHHLPVKESAAGRVYVQTESRKFKTLSMLLKSFTSSVMHLLGSLSDDMTLKLTLSSLTPILPYLLSFKKLVRALTKAVVNFWAQPASSETTRITAFLVLRRLVSIGDKGIREGALKATYQGLVQGCRITNHNTMQGINLMKNSAAELWGIDATVGYTTAFTLIRQLAIHLRNSIVHNENESFRMVYNWQFTHSLDFWSCVLAEHCSPLREAEAGKESQLRLLIYPLVQVTLGAMRLMPTALYFPLRFHLVRSLLRTCRATGTYIPLASPLLEVLSSAEMRKPPKLSKLEAFDFAVSYKTTKPYLRTRVYQDGVGEQVVELLSEHMLLWAKSIAFPELALPVIIQLKRWLKQTRSRASGNKNAKLGGQLALLVQKLEANVSFIEERRAKVDYAPRDRSQVAAFLADLDVAKTPLGAYAIGQRKARAERAKMLEDARREEERQRREDEKGGMQGDGESESEHEMGLEAESEPEDEDEDGDGDGDGDEVEDEDEDEDDNSGEDNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0N4</accession>
    <name>A0A367L0N4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_7822</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000022">
        <property type="protein sequence ID" value="RCI07995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0N4"/>
    <dbReference type="STRING" id="1330021.A0A367L0N4"/>
    <dbReference type="OrthoDB" id="9978720at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050228">
        <property type="entry name" value="Carboxylesterase_BioH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194:SF4">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194">
        <property type="entry name" value="HYDROLASE ALPHA/BETA FOLD FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="37"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI07995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="381" mass="41767" checksum="626DD1BFA19FA35A" modified="2018-11-07" version="1" fragment="single">TFYVRAYWADAGKVMRSGGHMYVERLDPLLIVHPLPIVFIHGDWHTGQIWTTKPDGRPGWAAYFLYQGYRVYVVDLPACGRSNSLTGSQVHVANQSPVPSKAIVSRDVTATASQTHEGWDSAKKHNKWPGTGQPGDGTFERYYASLVPLLLRKVDRQKLAQNALAELLENTGPAILIGEGTGATMAWLAADAKPHLVAHVMAIEPAGPPCGSARGQGLGGTRRFTPYIRLDPNVRAYGLADIPMRFEPPIPESDGEEEDGNANPKLDVLSTAMFNEVGATCVMQRCAENSHTRPHTQPRTLVNLQLMGHTIVTAQASSHSTYDWATVKFLRQAGVTVEGRRLEEYGVTGNGHLMFLEVNSDEIACLLCMWISARFPPQSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0X2</accession>
    <name>A0A367L0X2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DUF7707 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_7841</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000022">
        <property type="protein sequence ID" value="RCI08047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0X2"/>
    <dbReference type="STRING" id="1330021.A0A367L0X2"/>
    <dbReference type="OrthoDB" id="196717at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000029">
        <property type="entry name" value="CDP-alcohol phosphatidyltransferase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056124">
        <property type="entry name" value="DUF7707"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414:SF77">
        <property type="entry name" value="CDP-ALCOHOL PHOSPHATIDYLTRANSFERASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24808">
        <property type="entry name" value="DUF7707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="403"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="432"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="496"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="579"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="614"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="645"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="673"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="712"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7707" evidence="8">
        <location>
            <begin position="132"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI08047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="759" mass="83216" checksum="B770C1A18910029E" modified="2018-11-07" version="1">MRLITQASRGVCFLPIRTPYSVPTYLYLDLAPSLPLTSPLFLSSPLLSKYLSIPPLLSARLSSPLFALAFLSPLVARCNPTVFFCHTEPPPSWFFLFTIRHIPFPNITMPSLRSTVWAAVAAFSAVARADLSVDPSSVPMSTRQAWCADEKNTCPLICQQMEPRTTLINECDPKQLTYGCLCGNNQRPNISEYTLTLPYFICQEWGNQCVKKCNGDNECQGKCREDHRCGATAPKKGNGTTSTMSTPSATDDANTIFTDGPGNSKSDSKGAGVTLEVGRTYGMAVVLTGLFAGFALFLPSILTPGRPHPEPSSVFRLPRHSTGSDDRKVSGRNSLLFPPPGLAAAMAINSRTAAAECISDEALMHLKSYKYSAVDKSPVSKYVLGPWWNAFVRVLPMWLAPNMVTLLGFFFILGNVGLLVLCMPDLVGPGPAWLYFSFSLGLFMYQTMDNVDGKQARRTGTSSGLGELFDHGIDSLNCTLASLLETAAMGLGPSRAGVFTALCPCLPMFFSTWETYHTHTLYLGVFNGPTEGLLIASGIMALSGVYGPDIWTQPIAQILSRILPVGVARLLGETTSRDIWISLIISSLLVFHVPFCVYHVVLARRSKKLPIAPVFLEWTPMAVYTLSIGAWVFSPHSTLMRDNHLVLFCLTMSFVFGRMTTKMILAHLTRQPFPYWTVMLFPLVGGAVLGNLPLLGLPAVSAHAELLYLRAYFVFALAVYFRWAFLVVTSICNFLGINALTIPKEQQLANKRAQALKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0Y8</accession>
    <name>A0A367L0Y8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6256</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0Y8"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="137" mass="15394" checksum="00FB8B70BB3FE3CB" modified="2018-11-07" version="1" fragment="single">MSRLRAQGPWYDYCHTMDIMAVRRSGDERARHVMSCHASLFPPSIPIPPIPPQYQNRESPPPPPSAILPPTLQAPAPNLPSIRVPSPHSPRRSVQHANALPSECVSLVQMSCVKKISKTKRKTKQRLKFVLVLDNDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1K9</accession>
    <name>A0A367L1K9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1K9"/>
    <dbReference type="STRING" id="1330021.A0A367L1K9"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="201" mass="22520" checksum="5A8D6B16090A80EA" modified="2018-11-07" version="1">MPTYLCHGFRWERRKIRVFVLLHNLEEAAPDWVMGRRSAEELREQMEEMFDFVPRGGADEMGEEEEEEEERKGIQLLEEYDWNEREHATRPYAYVADYVVRVDLSVDVDEAMAGYRRDEGGGEGEGGEGEGGGGGGGGGGWLGLLRDRLQSGEEIRWYIVVCADEERSVEQEEQEEVEGGGGGGGGQEELTLALRSGPESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1V4</accession>
    <name>A0A367L1V4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8979</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1V4"/>
    <dbReference type="OrthoDB" id="5370011at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="335" mass="37375" checksum="50C7049A5890AAD6" modified="2018-11-07" version="1">MAESQSSSAPRAAKEKKPKRLGRVISKVMVALKRGESSKPQPSKTPATTREPPAPSKPAPLSKAAEARARYDGLEGVTRVIRSQLLQERAKKLAERYGLEISTSDLIKTSADDTVLRMDKPIRIRVRSTCHRCDTTLSVSKECPNCQHLRCTRCTRYPPKRTEAEKLASRERRAAIAQAIKDNPPIIADYSYTDTHVVLKRPSKTGGQDLHHKKPRQRVRRTCHVCQTVFMTGSNKCEGCAHVRCTDCPRDPPKKNKYPFGYPGDAFAPGSLPRYECERCESLLPSGAEMGLACRKCGHEMSDKTPRALPRKVEPEPDPEILRVIQARLDSLKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2T9</accession>
    <name>A0A367L2T9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tuberous sclerosis 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_8951</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2T9"/>
    <dbReference type="STRING" id="1330021.A0A367L2T9"/>
    <dbReference type="OrthoDB" id="6022054at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033596">
        <property type="term" value="C:TSC1-TSC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032007">
        <property type="term" value="P:negative regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007483">
        <property type="entry name" value="Hamartin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15154">
        <property type="entry name" value="HAMARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15154:SF2">
        <property type="entry name" value="HAMARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04388">
        <property type="entry name" value="Hamartin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="442"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="524"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="850"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="614"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="491"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="524"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="879"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="903"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="926"/>
            <end position="942"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI08532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="958" mass="106818" checksum="AD7E844FCCA7F538" modified="2018-11-07" version="1">MASPGQHLSKAVIASLTQPVLPLPENTLDAIAVYLDHHDKHDSADLDRLQDELSAIFEKHARGNLAASAPWIAIVWRLLPALPASDRIWPWFESCKGLLDRPGIVLDEVIAALVQLIEHYQPSSEENDSVTIPIIDVLLSISITRLYPALAQGNTSHEYNDKIVRRALKSFGKKRPKEFFAAVDAYFVRKQHRHASLRLLCDFIHEKPPHLHQVLHTSIFFNLLTCLQHDASTTVVSSALTVLIMLLPHMPNSLVPHLPTLFNIYARLLFWDRDRSRAAEAFADDAVLQSRGWEACAYDADIDDFDVPQLPNYYTILYGLYPINFMDYIRKPQRYLRHANISNPDDIEIQPTEMRHRSERFRRCHLLHSNFYTMTIDSEKTDNSRWIKSEAAEVLVACMELYYPADLRGPPPPMPGSTVEKDVNEPAPWAAAEGTLDSWRNSQLTSTDSEAEASNPPLSATLRRRVSHPSQAECRHATDQGQAADSPAMAAQSTHSPSSQGQLQDLIRSNKVIKSGLHQSLANDSVPSLSLSHQEPATQMPATMPQPAANSPPGPTVLGTQLANLQRRVLMLENDLSFERYVKQQHMAHIGELRRRQMVEAASEAETQNLIMLNRNLKSRCEEAKKAERQILKESERSRALAKKWESDLAGKLKLLRDESKKAGAELDALRRQLEESTGECEKLRKLVCDGEVKELNLQQSMQSVEIQKTEVDRLREQVEELTKSGHDQHTRELEREAALRSSAAAEAKVETMRMELAARKHDGDRERDLLRDQVTELQAQLAEAQGERARPGSNSNLAMESAFAASRAKQAELQKQYNLLMRKYTALQSSLLDMQSEAAAASAATATGIGMATRGPPGQEAADRSESECQPLSPVRTEATTTHDNNSSRAPRPVSYAGVPTSASAAEGSVSSERHFGGRLHSRSRKEARDKGGKEEGSGKAKKEKKPSGLRGIRGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3F7</accession>
    <name>A0A367L3F7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5059</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI08959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3F7"/>
    <dbReference type="STRING" id="1330021.A0A367L3F7"/>
    <dbReference type="OrthoDB" id="2156052at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052396">
        <property type="entry name" value="Meiotic_Drive_Suppr_Kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37171">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE YRZF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37171:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE YRZF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI08959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="601" mass="67495" checksum="8B72719031C5B3D4" modified="2018-11-07" version="1">MAAIRQPLDAPLLKRDIRNDADNQSDDQDDNVLLLKQTLLEYLQTCHRLTLAVEPATVDAIPSRDETTNPAGRSFPRRIIPWDTFAAQQQETWNLVGSHKSFFAERDYPYSLADTTNSNSPMTDDVQVRDFDLDAVASAVTTLINMACRDAHLRSTLGFFDRITVRCIRHVLDRSHASFNGKVEQWCSYSFESSGAVYPCLAMDYIAPWKLSLDEIMTGLASEIHLPGDIVDDSADNLQPKSLCAAAVTQLFSLMIERGTSYGYVCTGEAYIFLHIPLDASIVYFSVQSPKLMVGYNDEGALYHTAVAHIFALTLRALREGPACQNWYDRVEGLDSWTKSHQWSLKRNPKGPRPPVVHVGAVGESSHGRMQPRQNSWKRMREREYCTHKCLRGLLLGDEVDRDCPNAEEHGIIHLRLDLFWVLVKNQLFSDRGIDANCIPMGFAGGVASVYKLQLAVKGYTMVAKGVMAECWDSLTNESEIYEKLDDLQGKHIPVCLGFSGILGCSYKFDTRVCDCFLLLSYSGILPRRKDMTEEMMAKACAALTEVHNRGVLHKDIGPFNLLHQGDKVVIMDFEFAEVHEPGVDEQFAVEMDDLRDGMES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3Q6</accession>
    <name>A0A367L3Q6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_5144</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI09047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3Q6"/>
    <dbReference type="STRING" id="1330021.A0A367L3Q6"/>
    <dbReference type="OrthoDB" id="447103at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF3">
        <property type="entry name" value="N-TERMINAL KINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="670"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="553"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="613"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="681"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="720"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="748"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="758"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI09047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="768" mass="82728" checksum="88BDBE14D83CB6BA" modified="2018-11-07" version="1">MDFLKSAVASAIAQGPPFPYSFGDKVDLDQSIWTLYNGTKRASLGLRPEDGSNCSIFSFSVPANKGRLPLAKNALKKLRTLRHPGVIKVLDTVETDDYIYIATERVVPLAWHVRRKSLSPETIKWGLYGVARTVKFINSDASSIHGSLKIGSVYTSESGEWKLGGFEVLSSVKDDEPVIYTYGSLVPDSARYCPPEIVQGGWDVIKKNPHSAVDSFDFGVLIFEVCHGSYNGPDQAGQTKDIPPSMHSSYKRLCNANPKSRISVADFLLQGTRKGSFFDGPLIKLTEGIDNLGVKSPDERDAFLSDLVELNDDFPEDFFKLKVLPELIKSVEFGGGGPKALAVVLKIAAQFSQDDFIQKVNPFLIRAFANPDRAIRVCLLDNLPLVFDHIPQKVVNDKIFPQISTGFTDLQPVVREQTLKSVLVLVTKLSDRTINGELLRQLAKTANDEQPGIRTNTTICLGKLARHLGTSSRTKVLIAAFTRSLRDPFVHARNAALMALAATVEYFTEDDSSCRILPAICPLLVDKEKLVRDQANRTMDIYVQKVRKAAAALPDSALPPSQASDAQPARIETPQSSGPSSWAGWAISSFTNKVSTASGDMQTAGGASNAVQSKNSPSPDSKKSATASSSSLRHQVMRSPAADVSGTSSPSADAVAEAFFPDDGADTWADMGDMGDDDGAVDAPATTAAASPMAAPFDDGEPDFAGWLAAQAEKKKKPGAGKPLPKGLGKSAAAKKPTTKPAVKPVAKKIDMKPKETENDDDGWGDGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L433</accession>
    <name>A0A367L433_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein phosphatase 2C homolog 2</fullName>
            <ecNumber evidence="4">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_1507</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:47005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="4"/>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L433"/>
    <dbReference type="STRING" id="1330021.A0A367L433"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000016">
        <property type="entry name" value="Protein phosphatase 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF565">
        <property type="entry name" value="AT28366P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="13">
        <location>
            <begin position="23"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="344"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="399"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="462"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00074087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI09168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="479" mass="51985" checksum="CC7377B91AEAF65A" modified="2018-11-07" version="1">MGQTLSEPVVDKTSDRGEDDRLLYGLSAMQGWRISMEDSHTALLDMAMHYPDFYKTRPAKLSFFGVFDGHGGDKVAEFAGEHIHHIILQQRSFKAGDYAQGLKDGFLATDRAILNGSTTSSKNRPLHSDLDTSDPRYEDEVSGCTACVSLIADNKLYVANAGDSRGVLGIKGRAMPLSQDHKPQLDVEKNRITAAGGFVDFGRVNGNLALSRAIGDFEFKKTAELPPESQIVTAFPDVETHDLTPEDEFLVLACDGIWDCQSSQAVVEFVRRGIAAKQDLHKICENMMDNCLASNSETGGVGCDNMTMVIVGFLNGKTKEEWYEEIARRVANGDGPCAPPEYAEFRGPGVHHNFEESDSGYEMDGENKRKGFGTGPRGRIIFLGDGTEVLTDSDDAEMFDNADEDKDLDSQVSKKASPPPDKDGASSPKLTAAEETQPAVESSEPEARDGNKAAAAPSPSTKLKEEAKAGSPKETKDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4C1</accession>
    <name>A0A367L4C1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Enoyl-CoA hydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_1495</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4C1"/>
    <dbReference type="STRING" id="1330021.A0A367L4C1"/>
    <dbReference type="OrthoDB" id="14970at2759"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051750">
        <property type="term" value="F:delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000004">
        <property type="entry name" value="Delta3,5-delta2,4-dienoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000024">
        <property type="entry name" value="Delta3,5-delta2,4-dienoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045002">
        <property type="entry name" value="Ech1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149:SF1">
        <property type="entry name" value="DELTA(3,5)-DELTA(2,4)-DIENOYL-COA ISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149">
        <property type="entry name" value="ENOYL-COA HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI09283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="31814" checksum="A389FDE7FA7CC89A" modified="2018-11-07" version="1">MADTPSTAPPLPGYSYEHFRITRPLDQGQQHWTAHVEIDRPRKLNAFVPGMWRELGDVFRRLGREAEVRAVVLSGAGPRAFSAGLDIGDAAAGPLSAPGGEGDAARRAWAFRREIEEFQGCVGEVERCEKPVICVLHGISFGLAIDIASCADIRLCSRETRFSVKEVDIGLAADIGTLARLPKIVGSTTWVKEVCFTGREFSASEALDVGFVSRVLDDKASAVDAGLALAAVLAEKSPVALQGTKELINRGRELSTAEALRYTAVWNSVALQTEDVAVAIGRVVGKGKKKAVFEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4J4</accession>
    <name>A0A367L4J4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Acyl-CoA dehydrogenase/oxidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_1416</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4J4"/>
    <dbReference type="STRING" id="1330021.A0A367L4J4"/>
    <dbReference type="OrthoDB" id="10251155at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052904">
        <property type="entry name" value="Acyl-CoA_dehydrogenase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42707:SF2">
        <property type="entry name" value="ACD11 DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42707">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0274">FAD</keyword>
    <keyword evidence="2 4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="7">
        <location>
            <begin position="190"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="6">
        <location>
            <begin position="314"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI09331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="634" mass="67808" checksum="B026F53FE78BECF4" modified="2018-11-07" version="1">MQSSSADQGFFQEPPVLVNQFEDDVSFGRCFRLFLPAHVRAAAEAEVAALGQDVLADDVLAWISDAERNEPYMRGDGRDVFGRPAVELVTTEGWRKLRDFGIAKGQVACLLVRVKRLPNVASAAASSPVAMIRPSCANTGCPGAMQDGAASLLRKHLKTQSLSANQRHAMEDALTRLTSRNPASAWTSGQWMTERPGGSDVSQTETTAVPVRSPDDESLGPWAIHGFKWFASATDSDMAVLLARTSAGGLSAFFAPMRRHDAMARTKAGSPLADGSRLNGVRISRLKRKFGTRSLPTAELVLDGMRAWLIGDEGQGVRAMGAVLALTRIHSAVGAVGGIGRGLAVARAYARVRVVSGDGDGQSRIRLAEKPLHMRTLARMTAEYHGLMLLSFFAAYVLGLAENPLAAPLTTGPLAAMTPELELAEPLLRVLTQLTKAYVCKASVPLMFACMESLGGIGYLSTDGPVDLGRIFRDLCVGPIWEGTTDVLCADFVRALRRPGSGGRSLAALDEVVARAAAAAAGGGQDAEMPRPSDWQPAQRWASVRARILDAPQADAAAQARELVWEVAEVLVSLLLYVDAGSDDDPVAVDVLRRFLEAKQWVSPRARGTWREELARDSAIVYGVEGGSNLASKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4Y4</accession>
    <name>A0A367L4Y4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histone deacetylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_3657</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000015">
        <property type="protein sequence ID" value="RCI09468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4Y4"/>
    <dbReference type="STRING" id="1330021.A0A367L4Y4"/>
    <dbReference type="OrthoDB" id="5232919at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004407">
        <property type="term" value="F:histone deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09998">
        <property type="entry name" value="HDAC_Hos3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000011">
        <property type="entry name" value="Histone deacetylase HOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053244">
        <property type="entry name" value="HDAC_HD_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47558">
        <property type="entry name" value="HISTONE DEACETYLASE HOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47558:SF1">
        <property type="entry name" value="HISTONE DEACETYLASE HOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="2">
        <location>
            <begin position="223"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="563"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="671"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="735"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="614"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="678"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="698"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="791"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="864"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="931"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="962"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="989"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1012"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1047"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1064"/>
            <end position="1079"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI09468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1119" mass="119070" checksum="72A91B55689EC71A" modified="2018-11-07" version="1">MSSLSPARSATGKEDDEDAGLSQSLQELTLTTTAQPRRSSAFQRRRSSQTSARPGVSSRSPSSASRAVTPPLIRKASLNSLRSANGPRSLSRRSSSAHLSSPTPKAGLATSHEDAHEEDERPFVTANSVASDYFRAELDALDGPGSAPESDVIVVLNDAVYGHRYSRPRTSRGTLSTIVERPERIKATVLGIATAYVKLGRRHGNGMLPHLPWAPFRIRKTERRVPLTSAAVTNVHGVKWMEELKVMCDAAESRLAMGTKELQRPHANRAGSDAATPTKLHEGDLYLCAESLEAMEGALGAVCEAVDTVFSSAHRRAFVGVRPPGHHCSASHPSGFCWVNNVHVGIMHAMLAHGLTHAAIIDFDLHHGDGSQDIAWQHNSRSVTAAKNAAAWKKTSIGYFSMHDINSYPCEMGDEEKVKNASLCIDNAHGQSVWNVHLEPWKSEEDFWLLYETKYASLLEKAGHYLRRQAGRLRASNQTPKAAIFLSAGFDASEWEGLGMQRHRVNVPTSFYAALGRDVVKLAAEEGLAVDGRVISVLEGGYSDRALFSGIFSHLCGLVGDSRPSTTEVDGQEPVQAPTYTYDPSWWSSSELDKLEKPPEPPEPPRKPRVMTPPTYSTPTQASTAKVVDPEKMRRSLSGIGTARPMERPPTPPPPQVPWMVAAHELSKLIIPTGRQTDSCRPEDLNAEATRARRDRQSNLVTSAPVETSSRPTSRMALRERKTKVIVSIDEEAAELPAKSRRKTVGVSGVSAVDKSLASSTPALPQGPPSTRPGGGGGRRLSATPAPFGLAKEEALAAEAGHDDLGRPASAVVGNRPPSRGKLAVKKTRSTGGKDTASRAPPRSPKAPAKEEAQRPPGGPVSSAATGADTTDAMDGITAGMKRIKINLVTRSQREAREATASVKGDDATLSPPPRGDAMLSDGALQHATDADAGAIAARTPAGANDAGVNLAKTASSTGGRPVTPTTVVAPQASSALESPDPLQGPAVVNSSPRTMQPCQVGGGGDVFVRHQPSNPSSMSSSSSPQGEQQQQQQQPPLRWQPSNVPMMPPPPPPQPQPQPQPPSVTTTTKSSSPLTSPSAAGKKNGGLFHYTSSGIPFAPRSQPGDEGSVWEVPESPRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L594</accession>
    <name>A0A367L594_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_4149</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L594"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI09606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="44" mass="4973" checksum="D3B75F4128AEA193" modified="2018-11-07" version="1">MHRGFKSSCSDTWNPTLCGMWTFDWSLLSIPVGPRLVSSRSTRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5T2</accession>
    <name>A0A367L5T2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Pyrimidine-specific carbamoyl phosphate synthase-aspartate carbamoyl transferase</fullName>
            <ecNumber evidence="6">2.1.3.2</ecNumber>
            <ecNumber evidence="5">3.5.1.2</ecNumber>
            <ecNumber evidence="19">6.3.4.16</ecNumber>
            <ecNumber evidence="4">6.3.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">L249_4134</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29 30">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="24">Multifunctional protein that encodes the first 2 enzymatic activities of the de novo pyrimidine pathway: carbamoylphosphate synthetase (CPSase; EC 6.3.5.5) and aspartate transcarbamylase (ATCase; EC 2.1.3.2). The CPSase-function is accomplished in 2 steps, by a glutamine-dependent amidotransferase activity (GATase) that binds and cleaves glutamine to produce ammonia, followed by an ammonium-dependent carbamoyl phosphate synthetase, which reacts with the ammonia, hydrogencarbonate and ATP to form carbamoyl phosphate. The endogenously produced carbamoyl phosphate is sequestered and channeled to the ATCase active site. ATCase then catalyzes the formation of carbamoyl-L-aspartate from L-aspartate and carbamoyl phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>carbamoyl phosphate + L-aspartate = N-carbamoyl-L-aspartate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20013"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:32814"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18029"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; (S)-dihydroorotate from bicarbonate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="18">In the 2nd section; belongs to the CarB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">In the 3rd section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">In the C-terminal section; belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17">In the N-terminal section; belongs to the CarA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="29">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.2" evidence="6"/>
    <dbReference type="EC" id="3.5.1.2" evidence="5"/>
    <dbReference type="EC" id="6.3.4.16" evidence="19"/>
    <dbReference type="EC" id="6.3.5.5" evidence="4"/>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367L5T2"/>
    <dbReference type="OrthoDB" id="1924069at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00115"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005951">
        <property type="term" value="C:carbamoyl-phosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016597">
        <property type="term" value="F:amino acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004070">
        <property type="term" value="F:aspartate carbamoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004087">
        <property type="term" value="F:carbamoyl-phosphate synthase (ammonia) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01744">
        <property type="entry name" value="GATase1_CPSase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01423">
        <property type="entry name" value="MGS_CPS_I_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1370:FF:000002">
        <property type="entry name" value="Aspartate carbamoyltransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000036">
        <property type="entry name" value="Aspartate carbamoyltransferase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000025">
        <property type="entry name" value="Bifunctional pyrimidine biosynthesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1370:FF:000005">
        <property type="entry name" value="CAD protein-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000005">
        <property type="entry name" value="CAD protein-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000004">
        <property type="entry name" value="Carbamoyl-phosphate synthase (glutamine-hydrolyzing)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.20:FF:000002">
        <property type="entry name" value="Carbamoyl-phosphate synthase 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1030.10:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000002">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1370">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.20">
        <property type="entry name" value="Carbamoyl-phosphate synthase small subunit, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="entry name" value="Carbamoyl-phosphate synthetase, large subunit oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00001">
        <property type="entry name" value="Asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01209">
        <property type="entry name" value="CPSase_S_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006132">
        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006130">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036901">
        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002082">
        <property type="entry name" value="Asp_carbamoyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006131">
        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006274">
        <property type="entry name" value="CarbamoylP_synth_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002474">
        <property type="entry name" value="CarbamoylP_synth_ssu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036480">
        <property type="entry name" value="CarbP_synth_ssu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035686">
        <property type="entry name" value="CPSase_GATase1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006275">
        <property type="entry name" value="CPSase_lsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CPSase_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058047">
        <property type="entry name" value="CPSase_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00670">
        <property type="entry name" value="asp_carb_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01369">
        <property type="entry name" value="CPSaseII_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01368">
        <property type="entry name" value="CPSaseIIsmall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002032">
        <property type="entry name" value="PRK00856.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003671">
        <property type="entry name" value="PRK05294.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009455">
        <property type="entry name" value="PRK12815.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009475">
        <property type="entry name" value="PRK12838.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF5">
        <property type="entry name" value="CAD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405">
        <property type="entry name" value="CARBAMOYLTRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25596">
        <property type="entry name" value="CPSase_L_D1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00988">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02142">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00185">
        <property type="entry name" value="OTCace"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02729">
        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00100">
        <property type="entry name" value="AOTCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00101">
        <property type="entry name" value="ATCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00099">
        <property type="entry name" value="CPSGATASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01097">
        <property type="entry name" value="CPSase_sm_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00851">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53671">
        <property type="entry name" value="Aspartate/ornithine carbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="Carbamoyl phosphate synthetase, large subunit connection domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52021">
        <property type="entry name" value="Carbamoyl phosphate synthetase, small subunit N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 26" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="10 26" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-grasp" evidence="27">
        <location>
            <begin position="573"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="27">
        <location>
            <begin position="1110"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="28">
        <location>
            <begin position="1367"/>
            <end position="1545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00043968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00043979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00043984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00043998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00044063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00058513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00081752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="RCI09758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1879" mass="206075" checksum="813B120860500E7D" modified="2018-11-07" version="1">MASAVPLPPASARMASVADEGLVCLELADGSAVQGYSFGAQASVAGELVFQTGMVGYPESLTDPSYRGQILVLTFPLVGNYGVPSPEAVDDDVCRQLPAHFESASIHVAGLVVASYCGLDFSHFLAKSSLADWLKDQRVPAMYAVDTRALTKKIREQGSMLGRMRLQTRALPTNGLAVARVPPASPSASLDNFAAVDWLDPNEQNLVAQVSIETPKLYSPPGMSVATRSHPSGRPLRILCLDVGIKYNQLRCFLRRGVEVLVCPWNYDLTGVAHDGLFVSNGPGDPALLDVTVANLRAAMDRNKTPVFGICLGHQLLARAAGAKTVKMKFGNRGQNIPCTSMVTGKCHITSQNHGYAVDADSLPAEWVELFVNANDGSNEGIMHRHRPYFSVQFHPESAPGPRDTEFLFDVFLDAVVACSQQSALLQKPVEFPGGSADENERLHPRVSVTKALVLGSGGLSIGQAGEFDYSGSQAIKALKEEGIYTVLINPNIATIQTSQGLADKVYFLPVNADFVRKVIHYERPDAIYVTFGGQTALQVGIQLKDEFEGLGVKVLGTPIDTIITTEDRELFARSIESIGEKCAKSASACSVDEALTAVKDIGFPVIVRAAYALGGLGSGFANDELELVELCNKAFAASPQVLIERSMKGWKEIEYEVVRDAQDNCITVCNMENFDPLGIHTGDSIVVAPSQTLSDEDYNMLRTTAVNVIRHLGVVGECNIQYALNPFSREYCIIEVNARLSRSSALASKATGYPLAFIAAKLGLGIPLKDLSNSVTKETCACFEPSLDYVVVKMPRWDLNKFTRVSTQLGSSMKSVGEVMSIGRSFEEAIQKAIRAIDFHNLGFGPTKALMSIDDELQTPSDQRLFAIANAMHEGYSVDKIWEMTKIDRWFLRKLKSLSDFAKDMAGRTTREIARSPQVVLEAKRLGFSDRQLAKFWDSNEIAVRRLRQEAGIRPWVKQIDTVAAEVAAKTNYLYLTYNGSEHDVRFDDRGIMVLGSGVYRIGSSVEFDWCSVRAIRTLRTSGFKTIMVNFNPETVSTDYDEADRLYFENIDLETVLDIYQLEGADGVLGAMGGQTSNNIALPLHRAGVRMLGTSPEMIDMAENRYKFSRMLDRIEVDQPTWRELTSFEEARDFCKTVGYPVLVRPSYVLSGAAMNTVYSEKDLVNYLAQAASVSREHPVVISKYIENAKEIEMDAVASDGVVVGHFISEHVENAGVHSGDATLILPPQDLEATTIERIEEATRKIGAALNVTGPFNIQFIAKDNDIKVIECNVRASRSFPFVSKVMGVDLIEMATKAIAGLPFEEYPATTLGPDCVAVKVPQFSFSRLSGADPVLGVEMASTGEVACFGVDRYEAYLKALLSTGFKVPKANVLLSIGSYKDKREMLPSVQKLQRIGYKLFATAGTADFLEEHGVQAQFLEVLGRDEDMESEFSLTQHLAKNTIDLYINLPSNNKYRRPANYMSKGYKTRRMAVDFQIPLVTNVKNAKLLVEAMARHDYLDVSKRDCLVTQEPAAAGPEPSPSSKMMTMMMMPPDHHHHVRPLTREGAVGFSGDGSSSSISTSVMQLLAQPSCFKKANVLSVEQYTRADLHLLFTVAQEMRLGVQREGVLQLLRGKVLCTLFYEPSTRTSASFDAAMQRLGGRTVAVAASRSSAQKGETLQDTLRTLACYGDAIVLRHPDEGSVDVAAKYSDVPVINAGNGSGEHPTQAFLDLFTIREELGTVQGLTVTFVGDLLHGRTVHSLVRLLGHYQVKVQLVAPAGLELPAEMRERLAGSGQLLCECSALTPEVTGRSDVLYCTRVQRERFADEALYERVRESYRVDNGVLKHAKGSMVVMHPLPRNEEVAEEVDFDQRAAYFRQMRYGLYCRMALLALVMIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6E7</accession>
    <name>A0A367L6E7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein PET100, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_8407</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PET100 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6E7"/>
    <dbReference type="OrthoDB" id="18175at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018625">
        <property type="entry name" value="Pet100"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33968">
        <property type="entry name" value="PROTEIN PET100 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33968:SF1">
        <property type="entry name" value="PROTEIN PET100 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09803">
        <property type="entry name" value="Pet100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI10006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="83" mass="9951" checksum="F8D13600C3C0AD29" modified="2018-11-07" version="1">MGGINLEIFKFGMYVMFPIGIMYYFGTNLDNRFAVPGFWPKPEECNKVPHDREEIEAEYARIVERQRRRQAFMLEEEKRRGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6F7</accession>
    <name>A0A367L6F7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alcohol acetyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_8694</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6F7"/>
    <dbReference type="STRING" id="1330021.A0A367L6F7"/>
    <dbReference type="OrthoDB" id="2150604at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052058">
        <property type="entry name" value="Alcohol_O-acetyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010828">
        <property type="entry name" value="Atf2/Sli1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037:SF1">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07247">
        <property type="entry name" value="AATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI10015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="492" mass="54678" checksum="EEAFDE82DB79CE15" modified="2018-11-07" version="1">MLSSSSELAIASAIRLGLYRTVTVSSRYECKKRLGKGHLVRALSSIVSSQAMLRVGIEAVDDARFLHFHSIDLSRHLFFETLRTKRGEGEGGDCDDDELFRSKLQHFHDSTWEHAHLRPPWKVSVFYHDDDDDDDDKEKDVFCCDIVFAFHHSLADGISGRTFHQLLRRALNNNKDKDEPVRKNEKLVLLFPAPLPSVIPAPQEEAVPFSFSPSYWLKMHCIRLAANALAKPLNRYVNKVDDRANGSTLLLPINLSGCAAAALLAGCRSRKTTVTAVLHALVLTSLSRRLPRGSSSSFKAITAIDLRPYLDHRHGDDDDDASSQFRLLVSAYQQGFSVSEDEEESIWDAARIARVSLSARRDSLPADDIFGMPSCLNQVFSSWIALYGKSNLRSWLLSNIGVLDDDDDDDDDDEDDDNDEDAFCRISRVTFVGMPFLHGGPPIFVSVASVAGGAMTVVVSWVQGVVPHELATGLADDLRAWITNFADKGKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6G3</accession>
    <name>A0A367L6G3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6G3"/>
    <dbReference type="STRING" id="1330021.A0A367L6G3"/>
    <dbReference type="OrthoDB" id="2098203at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3440">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042831">
        <property type="entry name" value="Ribosomal_mL40_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39150">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L28, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39150:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="194" mass="22540" checksum="4A7D16AF630DC785" modified="2018-11-07" version="1">MAPVLSLLSLVARHLPRVPPRCRPLQTTTALNYPRAPPPSLKRGSVPKGKAKVGSKAGNQKKKKKKKGKGQARSEHYHKVRILTQNMFSPAPPPLRMARLRHLRHWTIHRAWQLFRRQHHERLALERHRLHAAMYNACEELRKTRGPGNRPEGSLYRVAMIKSGLWKFGFIPIEYARMQTETPAREAWNHAWKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6T5</accession>
    <name>A0A367L6T5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome biogenesis protein SLX9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_8602</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLX9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6T5"/>
    <dbReference type="OrthoDB" id="5065855at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028160">
        <property type="entry name" value="Slx9-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15341">
        <property type="entry name" value="SLX9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="74"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI10131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="133" mass="14569" checksum="751C084CF07AB14E" modified="2018-11-07" version="1">MSSMKSLAEALPLMEGEEEDANINNKKNSYPSVRNTTKTTHRQRSLPSKPGALKRRQRIVRGEMERFRASMARLATVPVEGSASEQPPSLPPSDGTDNDGRPPQPPSVADRWAALRGYISATVEQSPAFAHKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6V4</accession>
    <name>A0A367L6V4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TOG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_8384</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Spindle pole body</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6V4"/>
    <dbReference type="STRING" id="1330021.A0A367L6V4"/>
    <dbReference type="OrthoDB" id="205662at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990498">
        <property type="term" value="C:mitotic spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099070">
        <property type="term" value="C:static microtubule bundle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061863">
        <property type="term" value="F:microtubule plus end polymerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030951">
        <property type="term" value="P:establishment or maintenance of microtubule cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990571">
        <property type="term" value="P:meiotic centromere clustering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046785">
        <property type="term" value="P:microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000022">
        <property type="term" value="P:mitotic spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000019">
        <property type="entry name" value="Cytoskeleton-associated protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000282">
        <property type="entry name" value="Spindle pole body component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048492">
        <property type="entry name" value="Stu2_CTS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045110">
        <property type="entry name" value="XMAP215"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048491">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12609">
        <property type="entry name" value="MICROTUBULE ASSOCIATED PROTEIN XMAP215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21042">
        <property type="entry name" value="Stu2_CTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21041">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TOG" evidence="6">
        <location>
            <begin position="29"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="6">
        <location>
            <begin position="299"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="527"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="856"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="924"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="677"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="537"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI10139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="944" mass="101391" checksum="AF23AD5E64514503" modified="2018-11-07" version="1">MRRVRRLASFASGRRSGESAATRSDLDSSEATMADAEEDFSSLPLPDRFTHKAYEAAAKQFSLSPNESDPCFRPFLNDPGLWKSAVTDSNVAAQQEAVIALCAFLKFGGRDAALRTRNLTISPIVEKSLSSTRAATKQNALQVLLLYIELDTAAPVLEDVLPGLSNKVPKNVAATLNALTAIFHNYGCKLVDPKPVLKVLPKVFGAADKNVRAEATSLTVELYRWLREAMKPMFWGELKPTQQSDLEAQFEKVKAEPPPKQERLLRSQQAVAEAAPTGGDDGEVFDDEPEDAGAVDAFSLAEPEDISKKIPPNFTDMLASSKWKDRKEAVDALGQALNAPRIKDGDFHEVNRGLAKCMKDANVAVVSQAAQCIELLAKGLRQAFAKYRTIVMQPIMDRLKEKKATVADALGAALDAVFMATGLTDCLEDIIAYLGNKNPQVKEGTMKFLIRCLRTTRDVPSKPEIASICESGKKLLSESSPALRDGGAEILGTVMKIIGERAMTPNLEGLDDIRKNKVKEFFEAAEVKAKDKPKPAPAAKAPPAGAKKIVGGTKKPTMRKPTAAAPAVESSPLAPQPSSRLAASGSKLGLPKSTSGLGSLKAPGKRTLGAPGAASPRRSAVGVPVMPVMPAEDEPAAPPAQPRLGLPKSLTCRSLAKPNASLAQPRLDSPSPPSGITAVERAELEELRAANDRLARQLDDMRQERSKFMSEIQELKNQNAGLIEDHTRDVLSIKAKETQLVRARSDAEATEQTNERLRRELERLKRALSRAEGLGASSGMASPGELPSGGLTCSDATDHCLPVVMSPSHDDVGIYRDAGSASANRNRVSFASSLSEEKENGEVFYPRRKLSPELRYAGSVGSSGRGSPARGFRSAAFSQDDGVDSGTGAARERPASSLPTSASGGVESWKRAAEVTSQLKARIEQMKVGRRFDDDEDSEHAQTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7J5</accession>
    <name>A0A367L7J5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Probable aspartate--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Aspartyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L249_4309</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7J5"/>
    <dbReference type="STRING" id="1330021.A0A367L7J5"/>
    <dbReference type="OrthoDB" id="372395at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04320">
        <property type="entry name" value="AspRS_cyto_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000038">
        <property type="entry name" value="Aspartate--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024320">
        <property type="entry name" value="LPG_synthase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003483">
        <property type="entry name" value="PRK05159.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450:SF2">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="ASPARTYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09924">
        <property type="entry name" value="LPG_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="250"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="22"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="551"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCI10394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="881" mass="98934" checksum="A60DD38013F94B62" modified="2018-11-07" version="1">MPAPSAGILSVLGLPRRSRSKTSNIIITSGTRPADRGPMRGPLDGTTVAHSGGDPRGLANPSSSSAFVHLRRRSRMNDSGVELPRESARSSMDRSYASIDSGHSSADWPVHPFELNAIAELGSLPVDSEVNIRARIFTHRPLSKTLDFILLRDQTHSVQAVLSRDDVDMVRWVQKLPPESLVQVSGTLKAPPEPIRSATVDNMEIHVQSVHLVNTAHNAPFTNYKPPESLRNRMSSRILDLRHPSNQALFRIRSLVTRKFHDVLFDHGFVEINTPKLQPAATESGAAVFKVNYFNRNAFLAQSPQLAKQMSISADFGRVFEVGPVFRAENSNTHRHLTEYTGLDLEMAIEHDYHEVIDVIDEFLKSVFKAVYEMPEIGEVRSRWPSEDLKYLEKTLILDFSDGVQMLRDDGRDVADDEDLSTPDEIRLGQLVREKYDTDYYVLDRFPASARPFYTHKDPENAKWTRSFDMFIRGQEICSGGQRIHDVVELRANMRAAGIGEEGMDDYLDAFDLGAPPHAGAGLGLERIVAWMLELGDVRYASLFHRDPKSLPERTPGLAHPEADTTKPLADGGMLPPVEKLIANYGDASNTSWLDERFSIWRHPSGAAVGYVKQDKFAMMTGDPLCDASQYKEVCTAFVKFVVSELRLVPVWMLVSFDVQKMLARQMGWRTLSCTEEQRVNTDKRFSSIDGAKIRRVEREGVKMHEVKPDEDLIRRTEPGIQAWKANRKGRQVHMTEVRPWIDTEHRRYFAAEKDGRVQALVVLAKLSPKHGWQVKWALDFPGAVNGAIEVLIDYTLSAVHGPVTFGVGVSEKLKAGEHLHGIRARFLATTYNSIVESLGLRRKAGFRNKFGALGEEVYICYPKHGVGLRDLGQIVKFFQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8F4</accession>
    <name>A0A367L8F4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8F4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="219" mass="23920" checksum="F646A76B6A0E3751" modified="2018-11-07" version="1">MGSQSPRLFTWRKSLKPSIRNIKVSSELLANMLALIYKDLLSKKMEHACVEGLELSSGRGDQAIPPSLQIDPFPLATSISISDGKAGRLESAPFSLGRRRKRHDGHDPPDKPKGAVESGMCMYVAANSVDSTRRRRKGDALAHAVTYLRMRCNGRALLAASCHERNVTLLMVQLRVAPTESKEVALGVPTASTVKKTPKEAQLGLEESWKRGSSSSQVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L959</accession>
    <name>A0A367L959_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_5311</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0357 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L959"/>
    <dbReference type="OrthoDB" id="447314at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018559">
        <property type="entry name" value="DUF2015"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28023">
        <property type="entry name" value="UPF0357 PROTEIN YCL012C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28023:SF1">
        <property type="entry name" value="UPF0357 PROTEIN YCL012C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09435">
        <property type="entry name" value="DUF2015"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI10946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="130" mass="14633" checksum="9DE08F2B961752EC" modified="2018-11-07" version="1">MAYKYILFSFSVFLFIVATALFLTRHHWRPHVPAIRLPGAGYLYSQLPRSFVDDIDAGLTSDTFDLGGNVEAGDGRAGLENAAKAEILKIMKRRRMTFDQARKVYTENRFKANGIGADGRPRDPKFVSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9L7</accession>
    <name>A0A367L9L7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7303</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9L7"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI11109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="169" mass="19473" checksum="70E76DB780AB3B11" modified="2018-11-07" version="1">MSAKLVNYARTASNEEDIRRIAATGYKEAVKFFPEEKRPTSPERIYKKSFNKANKKTIAPNPVLTKVDNLTKQLNNPLDPSPGDRCVQPYNFGYYNSTNTDINRQKGAQKEALLAATNLRRRLNPEFRKDKILSYCNLLINTRRCRTNEFAVLRIIFPEKFLSIESPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAC8</accession>
    <name>A0A367LAC8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial inner membrane protein OXA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_7649</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXA1/ALB3/YidC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAC8"/>
    <dbReference type="STRING" id="1330021.A0A367LAC8"/>
    <dbReference type="OrthoDB" id="2148490at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032977">
        <property type="term" value="F:membrane insertase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032979">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane from matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001708">
        <property type="entry name" value="YidC/ALB3/OXA1/COX18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428:SF66">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEIN OXA1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12428">
        <property type="entry name" value="OXA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="366"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="27"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="389"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI11388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="415" mass="45121" checksum="B51419838FE774D4" modified="2018-11-07" version="1">MPGWPSSIPGWSSMPGWSSVFGKEKPSPPAEPPPQPSPAIEPPPPPPPPPPDPLPPASEASDVPILPDALTAQDILGMPETPGFLHAIGLDYGWGPTSVMQWALENVHVYTGLGWAGSIVATAVLLRLTMLYPQYRALRFGDVLNRMKADPRTAEAVKLGQEGARLKNLEMQQRSRALYKLLQKEYGFSGKGVGWSVIQIPFGYGLFRVVNGMAHIPVPSLETAGWLWFPDLAARDPYFILPALASGLMISSVLINSKYSSASQFKNMKPVMYIMGSVGLVVTTFLSSAVNLMGATMGAGTLLTSVFFNLASVRRLLKLPPTTTTTATTPKRNITYEAPRPATFRRRVTDSLNDVRKGFADQITSLTGSASASPSAEDSARNQRRAMLRKAEEARTRLREEEFQRKWKGGASSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAD1</accession>
    <name>A0A367LAD1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAD1"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="353" mass="36308" checksum="C3DA4F4B1A80FF0C" modified="2018-11-07" version="1">MTDQTTENNAAEGEARAGARGEWAGEAVVPDTVCPAYISSGVDAGQEVEVLEVESPAEEAADGQGEAEEAGEDGGENLGGAHRVKALVVPGEVRDAPCVLCLTGGLECRIQAGSTRAFSCAECATKGRRAAQSGQRRKDAEHLRRLMKSVTTTMRHIGLLEAAKYLPAGTTYQALSGAELIADDDDDTTAADAAAATILAAAGAAAASIPAAAAADDDDDEDDDSDEEESDDDDDDEADDDDDHDAPGLSAVVRVFRGWEGRLAAVEARVDAEAAAFRAELAAAAAKKKMKKNKKKKTTTKTPTTATPATPTKNRRGAAAATTATPTTPTKTPRKRAASAAAGSALKKAKKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAL9</accession>
    <name>A0A367LAL9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">USP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAL9"/>
    <dbReference type="STRING" id="1330021.A0A367LAL9"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000127">
        <property type="entry name" value="Ubiquitin C-terminal hydrolase Ubp8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF937">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="1">
        <location>
            <begin position="216"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="551" mass="62560" checksum="A2A69531AB91A59A" modified="2018-11-07" version="1">MASIPVSPKNFKVKPPSPGTPMFGCEHVQLLLSQGQEVMNSSIAHYKMILRCILDAAPIVPQTSTNHEGRPITCLTSNFLCLQCPTIVLEEDRLKHGFKKSHRFCELPERTSTLAVTLTDWQTWILETDVFIAKFAMTWSGILLSKNFVCANSEQDPSQVGTPSVEPSTCSRVCNCRLFPGRKRKHNELFTDSTKEDARYISANTVTPSCRANGLRGIYNAGATCYQNVVLQSFLHNPLLRNFYLSDGHQSNDCHVQHCLSCAMDDMFQDFYALENTNGYTAANILSGFWISEKKAFENLVTTKEQDAHEFFQFLAEELHERNGDGKRPEIGSEHSCNCIIHQTFYGKMLTTTTCQNCKGTSHAVQSFLDLSLGLDSLAHRRAKKSTQKMPALALTDCLDEEYVKFDKCEYRCHNCVSSQQAKRYTSIKLLPNVLSIQLKRFEYKQGRHDRAASKIDNVVQFPLQLNMLPYTNRVRSYESRESLELERSCIYDLLSVVVHVGEIETGHYVSYCRVGDQWFKFNDHKVELASVSDVLGAQAYLLFYIIRFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAW6</accession>
    <name>A0A367LAW6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">T-complex protein 1 subunit zeta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">CCT-zeta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_7564</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LAW6"/>
    <dbReference type="OrthoDB" id="10052040at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03342">
        <property type="entry name" value="TCP1_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000058">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000004">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012722">
        <property type="entry name" value="Chap_CCT_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027974">
        <property type="entry name" value="DUF4470"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02347">
        <property type="entry name" value="chap_CCT_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14737">
        <property type="entry name" value="DUF4470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4470" evidence="11">
        <location>
            <begin position="74"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="23"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1786"/>
            <end position="1816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="420"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI11561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1816" mass="202142" checksum="429A4D73A9C0FF0D" modified="2018-11-07" version="1">MHRRPLKRVFGDSVPDSNLWRVKAAEKFSRPQQRPPPPHTLPKKKKVRPSKAKTPPPFRILTPAVANRFNFFYPVGNTPAVNLTRNVPNDQDADILALGCGDLRNLLYTIYSQGKLPRRKLDFTLCDHDEDIIGRNFVLLTLMLENHLSVVWKLYYQYTVTRTQLDLLARHLKKMLALLESCDVWNSTPHGRYVKFCDDATFDYVSDVCKRLLFFSQHCSTRKFLEKLARPFAMSVNIRNQNIRNESMGDEAVSLSAIRSSAPSSLQEGWNFDTLHRRNWSDFINSQKRLEKNHPNPMFAAFLSEQKAYHYGSNPVLGFHLATAFAPLTDDSPLKPNRRVAEAAAENQFNKWMAAFKYAVLENLIRVRLVVAEPLAFSHTLQQAASTGNNSANWYARQFGLGQLVLDEIRYGPDNDSRPRPHPKTRKPPNRRAPMAFDVIDTSNLSDRFGALNVIVATTPLLKQKTWATILTETLIKRHESKEMDLDSLLCGHWPTVSLLLGIAAVQCWTNAKSEFHVDEVSMGHIDRSSGDTGERQSLSRLAWKRDDMFSGSLDGRGKLHLEPDAACRLLFHMYRRMFESENLQALLAAAVSPPKPEMASKQNSTYGHVHQSTFAALLKLVKSRVKTDWPDVCEGLIRSISQDRSLSLSANFIPELCLQMHLQGVYIQPWLLEGMGEPPSTGILSSWSQIPPSIVLTLVVPRESIDRLHNFSLKYEIASPMLIGSIRSHVKAREEFHHLYSDVHMVFGTVKDGPDGTIVVEEDELRWQGSSPLVVSFAVPAAFLRLQPPETRVMLEIMPSPQSNALYSRMLGLSLSVFGTTLGDSTRVFASRFMPGLDGHRIVCGGVRQLEDSVGDASKDRRLTISADIPESETRVSTLTCRVDVSSKWGLARLQSKRPLVLRQVDPFVIELVFQEEKGQFVSPLTFPCPVTKTGSKTRIDETSGYVEVVAPLADPLSTDVLSDFVFPTSMSLHSNPKDRIPVALNAPHMSLDTMPILDVNAEDRLGWLKTLTSFQFSAREVRLGLEKKAKGDRVADARINFKKSLLSMFKHCSPGLKGDKAVTFALNHPERGGLQMIFLVSALRLDGDAGSVVMDAAVLPIIKSNASSERIQSLVNETMRVGCRIINVDDAELVLWKRVLPAWVERCRTWTHLHDCQYRRTRLMTVPLSTELTKKFICACGKDKIPQDYLNMRKWKLARKHAFRVAISPTFAVPFVEDVVPSARELASMTDSLEVTGKRPSCNASKGEAITVTRMSAAQLLNPKAESRRRGEALKVNINAGVGLQDVLKSNLGPLGTIKMLVDGAGQIKLTKDGNVLLREMQIQNPTAVMIARAATAQDDICGDGTTSVVLLVGELLKQADRYIAEGLHPRILTDGFELAKVEALKFLDSFKLPKEVDRELLLNVARTSLTTKLNASLAQKLTPDIVDAVLAIYQAPAKPDLHMVEIMKMQHRTAADTQLIRGLVLDHGARHPDMPKRLENCYILTLNVSLEYEKTEINSGFFYSSAEQRDKLVESERRFIDAKLKKIVELKRELCGTDGKKNFVVINQKGIDPLSLDVLAKNGILALRRAKRRNMERLQLICGGASQNSVEDLSADVLGWAGLVYEQTLGEEKYTFVEEVKDPKSVTIMIKGPNQHTISQVTDAVRDGLRSVYNMIVDKSVVPGAGAFQVACAAHLKSDAFRNSVMGKAKWGVEAFADALLIIPKTLAANAGHDMQDALAALQDELAKGCVSGLNLESGVPMDPELEGVFDSFRVLRNSIASSSSIASNLLLCDELLKARQMGRQGGPGADGPEEMEQLGGMGLVDVYDNEMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBI5</accession>
    <name>A0A367LBI5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBI5"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="87" mass="9400" checksum="FA0E948E433CAFD1" modified="2018-11-07" version="1" fragment="single">ERKKNSEKFSKIQGKIQKEGTPFLSCSKEGSLTYPTFLPSRAVAVAASYVVVPFLPLLCNVRRPRAGYGRPDVTVSGAPAKVVAVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBK7</accession>
    <name>A0A367LBK7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7278</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBK7"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI11622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="80" mass="9088" checksum="2EDD80CAC98E4CE4" modified="2018-11-07" version="1">MLCSREVKSGSKAGVFPSISFMQSWITPTMVERSLWGRRTIDAIEARRINEFISKGEFSSWPGIEAVLVTMFDSEFHEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LC01</accession>
    <name>A0A367LC01_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ATP-dependent bile acid permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_7690</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LC01"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18596">
        <property type="entry name" value="ABC_6TM_VMR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18604">
        <property type="entry name" value="ABC_6TM_VMR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000565">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000825">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000010">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF353">
        <property type="entry name" value="ABC TRANSPORTER ATP-BINDING PROTEIN_PERMEASE VMR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="326"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="521"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="550"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="628"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="661"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1030"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1119"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1194"/>
            <end position="1216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1222"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1312"/>
            <end position="1330"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="331"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="730"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="1042"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1400"/>
            <end position="1650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="422"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="470"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="425"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI11762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1677" mass="184567" checksum="0FD6015C6A8E888B" modified="2018-11-07" version="1">MGAFAQCSLPIWRVDDLTPCFRQHYLQILFPLISVALSCACLAWSALAHAAARRRSKAYRPLNRHIATARDHTGLPPDENIGRDSEDDDDDDDDQPQLQINGGRLALAKTRSGGSIVQADTPTAQRLSQVVEELAIVGLIALNTVALLTRASRFVAAAGLVTWLYVFALASLRLFVAPTDRRLSGLWNHTAAIYGILWAIHLVIFRSALIHPASALVQVLDIIQFALVTVLFALALTTRKGNRTVKLVWEDGIEPSREPLASLFSLATFSWVNDIVFRGWKETLEMDHVWNLLPADKAAAVIADYRQLKKTSALAWHLLKFFKGMLIYQCFMAFLSGLFTFAPTLLLKAILEYVQRPDRAPVNVLWLMVIALPVLDTVRSYADGMALWTGRKICIRVRAIIIGDIYAKALRRKAAAGRDKILLDNNNNNNNNNNNNNNNNSRSAAKEAESDGENAAAKIKGVLGIGKRKSKKASSSTGSDSDPADGLIGDESQAEGGDDEQANLGTIINLMSVDSFKVSDVTAYLHFLCAAAPTQLVICVVLLWRVMGLSAIPGLIVMALLLPVNYFLARGFNITSKNIMAATDKRINVTNEVLQNIRIIKYFAWEERFGRIIDEKRRAELGALRSRFILWAVAVAIWNSVPVLITFFSFLVYTLIEQKPLYPSIAFTAISLFMLLRVPLDQLGDMFAHVQESKVSIDRVQEFLDEEETEKYQQLGLDNADEEGVRRIGFRGATLIWGGRDTVASDGSRAFRLLDVDVDFAIGKLNIIAGPTGSGKTSMLMGLLGEMTLMEGRVFCPGGRSREDVRPDPETGLANTVAYVAQAAWLVNANIRDNILFAAPLDEARYRDVIVACALERDLDVLDHGDETMVGEKGITLSGGQKQRISLARALYSNSAHVLLDDCLSAVDSHTAKWIFTNCIKGPLMRGRTCVLVTHNLQLCVPSADYIVVMDNGRVAAKGPARDVIASGRLGEELQRSRCCCHEHNPNDTFRSLAISGKAKASNSKKAQADLGRREETKATGSVKWPVMKLYLLSMGPWWFWIVALVVFNLQQLSTVGTNFWVRQWANQYVEGQPEALFVPSSLTASSRGGSLTKGSWARFGGGGGGGGGGGFAGADVNLAYYLTGLAALGTAGALAALVRDVWIFYGSLTASRKLHDRLMSAVTRARFKFFDVTPLGQLMNRFSKDLEAVDQEIAPTAIGVMSCALSLVVTVVLIAVITPGFLVAAVFISVLFYLVATLYLRASRDLKRLESVQRSPLFQQFGETLSGVTTIRAYGDERRFIRDNLAKVNTQSRPFIYLWACNRWLAFRADALGNLVSFFAGVFIILNLGKIDAGAAGISLSYAMNFTENILWLVRLYGMNEQNMNAMERVKEYLDLEQEAPPVVEDGRPPASWPDEGNVEFVDYTTRYRTDLEPVLRGISLRIRGRQKVGIVGRTGAGKSSLALAIFRALEAEKGRIVIDGVDIGRIGLRDLREKIVIVPQDPTLFTGTIRTNLDPFDQHTDGQVFEALRRVQLISLDEPSSSSSSRPSSSAAATNKNIFLDLSSPVTESGSNLSQGQRQLLCLARAMLKRPKVLVMDEATASIDYGTDSKIQETIRELTGTVITIAHRLQTIVDYDRVLVLDQGEVVEFGHPWELLSREEGSFRAMCDMSGELEALTRAARRKWDEDGRGGGRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LC32</accession>
    <name>A0A367LC32_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000008">
        <property type="protein sequence ID" value="RCI11977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000253664">
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    </dbReference>
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            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
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            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="96" mass="10204" checksum="2418A64555CF1E0F" modified="2018-11-07" version="1">MAGPYNAQVHQTLREASLGTPRTSTRSTASYEPSTSDSSPPRSISPGTRRVYGASLHEASVTRSSNGTTVINYNMTGYQPGSPSPSYGRTYATNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCF8</accession>
    <name>A0A367LCF8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Formamidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_0717</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1330021.A0A367LCF8"/>
    <dbReference type="OrthoDB" id="9975579at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.580">
        <property type="entry name" value="Acetamidase/Formamidase-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004304">
        <property type="entry name" value="FmdA_AmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054833">
        <property type="entry name" value="FormamaseFmdA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF045496">
        <property type="entry name" value="FormamaseFmdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31891">
        <property type="entry name" value="FORMAMIDASE C869.04-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31891:SF1">
        <property type="entry name" value="FORMAMIDASE C869.04-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03069">
        <property type="entry name" value="FmdA_AmdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141130">
        <property type="entry name" value="Acetamidase/Formamidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI12118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="412" mass="44702" checksum="FFC55C45CE303AD2" modified="2018-11-07" version="1">MPGKIRTIQSVSFDVPASEQPHLHNRWHPDIPAVASIKPGETVKIECLDWTGGQIGNNDSANDVRDVDLTEVHYLTGPFDIEGSEPGDLVVVNITDIQPFDHSPWGFTGVFARENGGGFLDRHYPRAAKAIWDFDGIYCSSRHIPGVRFAGLIHPGILGCAPSAELLAEWNRREGELVTACRHSHPDQVVALSPLESKVHAGQATGEAKAKIAREGARTIPGRPEHGGNVDINNISRGSTTYLPVHVAGAKFSVGDLHFSQGDGEISFCGAIEMAGIITINFGLIKNGMKEKAIKSPVYRPGDVAQLFSPSRYLTFEGFSVDESGKQHFLDATVAYRQACLRTIEYLQQFGYSGEQAYLLLSCAPIRGSIAGIVDVPNACTTLGLPMDIFDFDISVEAERRTRSMASCALCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCV3</accession>
    <name>A0A367LCV3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small ribosomal subunit protein uS17 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_0253</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCV3"/>
    <dbReference type="STRING" id="1330021.A0A367LCV3"/>
    <dbReference type="OrthoDB" id="10254436at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00364">
        <property type="entry name" value="Ribosomal_uS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.1000:FF:000001">
        <property type="entry name" value="40S ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028333">
        <property type="entry name" value="Ribosomal_uS17_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_uS17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032440">
        <property type="entry name" value="Ribosomal_uS17_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03630">
        <property type="entry name" value="uS17_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744:SF9">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16205">
        <property type="entry name" value="Ribosomal_S17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS17 N-terminal" evidence="5">
        <location>
            <begin position="54"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI12241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="207" mass="23683" checksum="858D2E890F3172E2" modified="2018-11-07" version="1">MDMRLRRVGSEALPILLYAEQLIVLQQPPRHASCNDASSEQDRSTCQATELTVQSERAFQKQPHIFQNAKVKTKSSRPGKNGRRWYKDVGLGFRTPKTAIEGSYIDKKCPFTGLVSIRGRILTGTVVSTKMHRTVIVRREYLHFIPKYSRYEKRHKNLAAHVSPAFRVEEGDQVTVGQCRPLSKTIRFNVLRVLPRTGKAVKKFSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCY2</accession>
    <name>A0A367LCY2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCY2"/>
    <dbReference type="OrthoDB" id="4927326at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016834257" description="Extracellular membrane protein CFEM domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="118" mass="12052" checksum="BB47627E667A27D5" modified="2018-11-07" version="1">MKFAIATLALASIASAASAGNSGMQASAQSQAEALDIGKLLGGLKPLLKKAKCVAPCFSKKTDALECSDKGPLSTICTNIDNIARGCEGVIKKCGVDKSTTGTVSKVLKDMCATIETR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LD59</accession>
    <name>A0A367LD59_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Isoleucine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L249_0214</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Ile) + L-isoleucine + ATP = L-isoleucyl-tRNA(Ile) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LD59"/>
    <dbReference type="OrthoDB" id="10264412at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07960">
        <property type="entry name" value="Anticodon_Ia_Ile_BEm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000111">
        <property type="entry name" value="Mitochondrial isoleucyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033708">
        <property type="entry name" value="Anticodon_Ile_BEm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050081">
        <property type="entry name" value="Ile-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42765">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="2054"/>
            <end position="2075"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="14">
        <location>
            <begin position="30"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="15">
        <location>
            <begin position="700"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="958"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1040"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1095"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1206"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1276"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1366"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1509"/>
            <end position="1686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1711"/>
            <end position="1795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1822"/>
            <end position="1892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="965"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1118"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1302"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1425"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1463"/>
            <end position="1475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1573"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1606"/>
            <end position="1628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1712"/>
            <end position="1722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1779"/>
            <end position="1789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="1860"/>
            <end position="1880"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCI12359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="2101" mass="233209" checksum="1F0C8EFD03BD46E9" modified="2018-11-07" version="1">MRSWKETLRLPRSTFKARPNLQLLRNNREAADLYQWQATHRHQDDLFVLHDGPPYANGPLHLGHALNKVLKDMVLRLQVQKGKRVLYRPGWDCHGLPIEMKALEADAARALSPVSIRRAAKRLATKAIAGQLTGFQSFGVMAAWDDKWTTMGHAFEMRQLRIFQKMLRHGLIYRKYKPVYWSTTSRTALAEAELEYRDDHVSHAAYVRYPIVSDCSAIPGLADFTHGLYAAIWTTTPWTLPANRAIAVHSHLLYSVLRVGDHGLIVASSRVEALREHLPSFEVAVEGITGEQLAGLTYRNKLRGKAAPSQPIVHADFVLADSGTGLVHMAPGHGQEDYEACSALDIAAFAPIDDDGRFTLEAFPDQPQLLTEAPSILQGGSQAVLDLVGEDVLAVHELRHKYPYDWRTKQPVVLRATAQWFADVGSIKEAALAALGGVRFVPESGRARLESFIKRRREWCISRQRCWGVPIPALYDADGKAVMTNESVEHIISVMQERTSEAWFSDAADDAAWIPPSLKQGRYHRGTETMDVWFDSGSSWTETTQQADVYLEGSDQHRGWFQSSLLTYVAEQKLNGKTDDEITAPFKTLVTHGFVLDAQGKKMSKSVGNTISPDELILGHLSPHRDKARAGEKGGGKADALGPDALRLWVASSDFTTDVVIGPSIMQPVHNALVKYRTVLKMILGSVHQSSRSATLTKVDQMAIMQLEDTMKQVRDAMDAYEFPKATALINRWVANDVSAFYLEALKDRLYCGDGGGALEPILVGFLRMLAPMTPLLVDEAWSNRPQWMADDETLQHPGRQLYGEPVVDARRLTVSQSRLRRDLPSLMAVRGAAKAGLEEARAAGVLGSSLQSSIVISTEDRELAATMGFYLDELDAMLVVSHVGLNEQMADGGWSFVKPFEGGRVHVLPPRHHKCARCWRYLATSEHQLCGRCDEAVRHQHAIQEGLTTLDSLPSASASYEMGESSARASSRPPSEDAQSADSRTRRARHRSAGGFMLRDPAPSDRHLARRRFAHDAPHSKSRAKPTPRTVDTIVRPNRGLAMSSDPAMRDSMHSRVQSSVDSDYGTGPDVDTAQIVNMALSLSESRKLAARGNNNLARGTPPRLAPLPDGSSASNLRQHLQQQRRSSLTQSPVSASSASPRRASGVRFGSSRLSESDSGVDGQYRYHFSPSTLARAQKARQTLELMTEYRRLLPALPPVKSLDALPPRCSSPSRAAKRKVANQAHGREYNPLQYIRNRKVRARERMVINGDRQGFGDVEDVRQWVDKVRQRSTILNADAEDEDDGPAMPPFPGPDGGADGQTSTQAAAATSSPAAARSRRPRVDWFVEPSDMIADAYWLEQNHHKFLIEDRKWRKILSPPVDPIRPVSSGSGYPGSGTAQSLSLRSEGLTEPTASAVSKLDMTGNGKGTKDRAKQKLQNMKAFPHRHTGSLHGHPHRRHHHPPRHPDLKRPRRHSAGDVLIKQEKGQTRHDQTRTPTSSANDLLERQMMEMVANEAHELEMTEPPVVDEDQVMGPPPLAAPRKSNSTTDSDRRGGDGGKQTMDSPRRRRPVQWGADVPTTQPPAPSFPLPQASEDAAEQATTSSSTSGRHESPTRNALFKFKHAIRDKNGDAGEDASHDGDRDPSGRKSTSSPERAGPSKRRPSSPAKLSAFERPSENSRTHKMSKSLRHRSDNPGVGLRGLFKGPRLDTVFRGGVFKLNDMLWRKDEPVAEPDSTDESESERTRGRSKMLSPSKRSHDENRPGPRNFLEFMPEFSHAPGAQSRNAGYDCGKETATSSPSRPSRPSSQIETLKPPLSGIWSEYRSASVSPSPFPLDVWRVRGSGGGGGDSDLWDSESYQGSGGREGATDEASTDPPRHKQHHDHQHQHDHHHHHHGRHWSIADKTTYTGPPTRREIARVKVLMLSSGIKALGISRRSVEVPAPGNTKWATELLQRLGGGEKVNSGKTTMTLPPPCELYPLAGRTIRTAMLSSSRHWQASATRLTSQTSPELHRRIGEVRARLTDELSEMARMAANEADETGQELALGQPLKLKHVVDMMDRMLRRRRRRLRWLRRALWLIVEWMLVGLMWYVWAVVMLLRVVSGVGRGCWTGLRWLFWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDA0</accession>
    <name>A0A367LDA0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_0451</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDA0"/>
    <dbReference type="STRING" id="1330021.A0A367LDA0"/>
    <dbReference type="OrthoDB" id="21204at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053238">
        <property type="entry name" value="RING-H2_zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14155:SF627">
        <property type="entry name" value="OS06G0192800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14155">
        <property type="entry name" value="RING FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="373"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="309"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="478"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="478"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI12408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="604" mass="66742" checksum="902789D014952924" modified="2018-11-07" version="1">MSLIEIQNAILLVSNPVWEGDKTVPSTLVRNISALSSQIGYEDRISTNLTTLTTTNAPKLEGTFGGLLFVPQITAVPDCDAQQYDFLPRNVTRREQLPPSNLNVVAIAPWFSIECTRAYLASAARGSARALVFYKPNNSTNKPQEVDSPVWSLDDDDAWRKNHHFPIFAIPGLEGQKIVRQLSLYSGSIDQVPHGQEIGQLYGPNPSDYVRVWTDLTMQNTSNVPAVWAFVLIVIGALLFVIAVVSLAMHFIQRRNRSSLRRRVRSGEVDLEAMGIKRLTVPASHVDRFPLFTYNAEADLQAAPRSPPVDAALAHAARRPSRKGRRGADHRSASADANTVGTRSVRSVRSIRSKRSSITGTTDTTATNFQPNCHICLAGFEHCRTIIRELPCGHIFHPACIDEFLTQNSSLCPMCKHCMLPRGYSPKITNGMVRREQAVRRLREHVDLEDSSFDSGELKLKEWGKRLFTVSHAAAKLPASDAPPTGDAAASASASASATPRPPDPEAPAPTHKMDPRRIRPRALRPLPTHHEGTEPKEEEQEQEQERRAGAAAAVVVVGRLSPSSFARERMRQIAASNAPFDDDLDHPRPKWRRLLSKAFPGFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDK8</accession>
    <name>A0A367LDK8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">UEV domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_0602</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDK8"/>
    <dbReference type="STRING" id="1330021.A0A367LDK8"/>
    <dbReference type="OrthoDB" id="306304at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072666">
        <property type="term" value="P:establishment of protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11685">
        <property type="entry name" value="UEV_TSG101-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052070">
        <property type="entry name" value="ESCRT-I_UEV_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017916">
        <property type="entry name" value="SB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008883">
        <property type="entry name" value="UEV_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306:SF3">
        <property type="entry name" value="TUMOR SUPPRESSOR PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23306">
        <property type="entry name" value="TUMOR SUSCEPTIBILITY GENE 101 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05743">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09454">
        <property type="entry name" value="Vps23_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51312">
        <property type="entry name" value="SB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51322">
        <property type="entry name" value="UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="UEV" evidence="10">
        <location>
            <begin position="6"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="SB" evidence="9">
        <location>
            <begin position="420"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="147"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="248"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="284"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI12505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="488" mass="53760" checksum="F7D29180A2F60EE3" modified="2018-11-07" version="1">MPVQQHVLNWLYSVLTSEYHDVNHTYNDVARVLNRHSTLSPRTDVHTFFDGTSALLLHLSGTIPVVFRGSTYRFPLSIWVPHAYPREPPLVYVTPTQSMVVRPGQHVDPQGQVYHPYLARWSDFRDKSTLEDFLAVLTDVFAKEPPVVSRQAPRPVQVERSTPPPPPPVPPLPPEMASNQPRHIVSNEQQPPLLPPKPQDSQPLDSQTLAVTASRYDSAPPLPPEAQEAPVHEQVLRPQAYVDQRMSIPAPSPQMAPPMTHQTAASPHTPHGLMSQPRSPWIEPPTTQRTTPTPAAAPPNILDEPQEVMADTTAVAAPPIPPNPEKDALLQQLAETLATMRKRSRQQDESSMAGLKAQRGAMLAAMAALQSEASQLTQLSQVLTSNTKILHEALHKADGVIEGSCNHPAAEMDELLVAPTVVANQLYNLVAEERALGDAIFMLGRAVERGRISPAVFAKTTRSLAREWYLKKALARKIGEGMGMYSHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDP4</accession>
    <name>A0A367LDP4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit SPC19</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Outer kinetochore protein SPC19</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L249_0838</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex SPC19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDP4"/>
    <dbReference type="STRING" id="1330021.A0A367LDP4"/>
    <dbReference type="OrthoDB" id="3361333at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013251">
        <property type="entry name" value="DASH_Spc19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28262">
        <property type="entry name" value="DASH COMPLEX SUBUNIT SPC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28262:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT SPC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08287">
        <property type="entry name" value="DASH_Spc19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="108"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="151"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCI12548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="185" mass="20951" checksum="6D3F757BC8ECF450" modified="2018-11-07" version="1">MASAASSSHADCVSSLRSSLRFLESSVQTLEAGVSDFPRLVRVLKTVRHYELVSQPTLAAAEASLRDEIGPYVALLLSRADAQIERQDRRIETLKARHDLQQGRLVRPAAGDEKEDDVAAHHHHHHQQPRSCSSGNSLSRKLLAPEDRLRARALRQRKEALRYGVERLELEVLQKQRELKRRLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDP8</accession>
    <name>A0A367LDP8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_0299</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDP8"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000014">
        <property type="entry name" value="MFS drug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF158">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14490)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="461"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="500"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="581"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="111"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="59"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI12540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="621" mass="67027" checksum="25A44E5A0EE88451" modified="2018-11-07" version="1">MHYHVKRISLHLLIPPFPPSAIAIAIAIAIAITSHLQVPSYVPDTTTYYSLFRMMEENAAPPTAPPPPKPSAPKPSPTDMEESPPPPNEPLDLSSSEEQPSVRSKLRIYTILVALCLELFIAALDQTIVSTAAPSIVANLHGSLGYTWIGAAYLLANAAAGPIWVKCSDIWGRKPAILSAIAIFAAASIVTAASVNMPMLIAGRALQGAAGGGLMQLVNITISDLFSMRSRALYLSAMGLVWVLAGTTGPVFGGALSQYASWRWCFWINLPVCALTFVVILFFLDVHNPRTKLGQGLMAIDWLGTLSMLAVTLLLLLGLDFGGVIYPWNSPKVICLIVFGSLMMAFFLYSEKRLARYPLMLLSVFQGWSNNAVVVVAFTHSMASFGVEYYLPLYFQSVKQASPLQSGLLLLPMIITCAIVDILAGVFMHQIGRYRELIWAGTALMTLGAGLYTMFGTDTTLGTIVGFQIIFGFGMSLLFQTPTMALQNSVSQADTATAMATLSFMRSLATSLSTVLGGVVFQNSMTVRSPSLAASGLGKPQLEALSGYQAAANVHLSQTIDDPAKRRAVEEAFAWSIRNMFIMYSCIAAVGVLASAFVKQRHMSKEHTETKTGLENMTKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDY4</accession>
    <name>A0A367LDY4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_1233</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDY4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI12633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="115" mass="12007" checksum="DAC6FE5096BAF583" modified="2018-11-07" version="1">MGKPSHDVSPSGAVSKGPDSPTPSFPPAVCGSHRCHPSGFQGVVMQFVVVSGLLFVVLVRKASDAEIRSQELQGRTKFTSEVAPVTGSVGSVLGVTLGRSTSREVDEMGVGLLWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEE1</accession>
    <name>A0A367LEE1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_0091</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEE1"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI12789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="66" mass="7630" checksum="236594C4F01349FF" modified="2018-11-07" version="1">MKWRRGERGYGRSRTPPLVARSPWLFWLAGRLLASPFSPIWAMGCAEMDSFFYGIADRTQVRIVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEF1</accession>
    <name>A0A367LEF1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="16">ATP-PFK</shortName>
            <shortName evidence="16">Phosphofructokinase</shortName>
            <ecNumber evidence="16">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">L249_0729</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 16">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16 17">
            <text>beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="16">Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5 16 17">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 16">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Mitochondrion outer membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="16"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEF1"/>
    <dbReference type="STRING" id="1330021.A0A367LEF1"/>
    <dbReference type="OrthoDB" id="537915at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005945">
        <property type="term" value="C:6-phosphofructokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070095">
        <property type="term" value="F:fructose-6-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061621">
        <property type="term" value="P:canonical glycolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030388">
        <property type="term" value="P:fructose 1,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.450:FF:000010">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000007">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.460:FF:000008">
        <property type="entry name" value="ATP-dependent 6-phosphofructokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="entry name" value="Phosphofructokinase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03184">
        <property type="entry name" value="Phosphofructokinase_I_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009161">
        <property type="entry name" value="6-Pfructokinase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015912">
        <property type="entry name" value="Phosphofructokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02478">
        <property type="entry name" value="6PF1K_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697:SF4">
        <property type="entry name" value="ATP-DEPENDENT 6-PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13697">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000533">
        <property type="entry name" value="ATP_PFK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="Phosphofructokinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00433">
        <property type="entry name" value="PHOSPHOFRUCTOKINASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="12 16 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14 16 17" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="11 16 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="13 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16 17" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphofructokinase" evidence="18">
        <location>
            <begin position="6"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofructokinase" evidence="18">
        <location>
            <begin position="398"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal catalytic PFK domain 1" evidence="16">
        <location>
            <begin position="1"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interdomain linker" evidence="16">
        <location>
            <begin position="384"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal regulatory PFK domain 2" evidence="16">
        <location>
            <begin position="398"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="77"/>
            <end position="78"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="107"/>
            <end position="110"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <begin position="153"/>
            <end position="155"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <begin position="197"/>
            <end position="199"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <begin position="291"/>
            <end position="294"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <begin position="532"/>
            <end position="536"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="570"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <begin position="577"/>
            <end position="579"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <position position="637"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="663"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <begin position="669"/>
            <end position="672"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="16">
        <location>
            <position position="741"/>
        </location>
        <ligand>
            <name>beta-D-fructose 2,6-bisphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58579"/>
            <note>allosteric activator; ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00002659"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004570"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR000533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RCI12799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="784" mass="85776" checksum="B1EB0C94E3F09748" modified="2018-11-07" version="1">MAPKKKIAVMTSGGDSPGMNGVVRAVVRMAIHLGCDAFAVYEGYEGLVRGGDLIKQMDWHDVRGWLSEGGTLIGTARCMAFYERPGRLLAAKNMVLHGIDALIICGGDGSLTGADRFRSEWPSLLAELVQKGQLTVEQTKPYKHLNIVGIVGSIDNDLSGTDATIGCYSALSRICEMVDYIEATASSHSRAFVIEVMGRHCGWLALLAGVATGADFVFIPERPQDHDWRQEMSDVVRRHRKLGKRKTIVIVAEGARDKDGAKIHPDAIKDLLADKGEGSLGLDTRITTLGHVQRGGTAVAYDRTLATLQGVEAVKAVLEATPETETCFIAITENKIVRKPLMRAVQETKDVAAAVEAKEFDRAMSLRDTEFADQYRSYLTTTNALAGDRSLPEKSRMKIGFINVGAPAGGMNAAVRAAVAYCLSRGHEPIAIHNGFAGFARHHGDKPLGAVRPFDWLEVDGWASKGGSEIGTNRELPSESGMELIANLVEQYQFDALFIVGGFEAFHSVSQLRKARDDFPSLCIPICLLPATISNNVPGTEYSLGSDTCLNELVHYCDKIKQSASATRRRVFVIETQGGRSGYVATLSGLNVGASAVYIPEEGISLEMLNADVKHLKEVFRKDRGQSRAGRLILVNEKASKVYDAKLIASIIRDEAHDRFESRESIPGHVQQGGVPSPMDRCRAVRLAIKCIQHLEDFGRNAHNRVKKDPNSTTVIGIQGTEVVFTPMKKLEEEATDWPNRRPKHAYWLHMREVVDILGGRPDYPRPERSLEGLLAKDTKRGIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEJ2</accession>
    <name>A0A367LEJ2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0624</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEJ2"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="51" mass="5233" checksum="67B989DD76A54EEC" modified="2018-11-07" version="1" fragment="single">HDSAYESRAESGMHTVREGPVAPAGPCGGAGAGRDGCARMMTCRLWDGIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEQ5</accession>
    <name>A0A367LEQ5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA (cytosine-5-)-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_0143</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.37" evidence="2"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEQ5"/>
    <dbReference type="STRING" id="1330021.A0A367LEQ5"/>
    <dbReference type="OrthoDB" id="5376140at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003886">
        <property type="term" value="F:DNA (cytosine-5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044027">
        <property type="term" value="P:negative regulation of gene expression via chromosomal CpG island methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04712">
        <property type="entry name" value="BAH_DCM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.120.10">
        <property type="entry name" value="DNA Methylase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050390">
        <property type="entry name" value="C5-Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018117">
        <property type="entry name" value="C5_DNA_meth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057215">
        <property type="entry name" value="DUF7893"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629">
        <property type="entry name" value="CYTOSINE-SPECIFIC METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10629:SF54">
        <property type="entry name" value="DNA METHYLTRANSFERASE DIM-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25423">
        <property type="entry name" value="DUF7893"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00105">
        <property type="entry name" value="C5METTRFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00094">
        <property type="entry name" value="C5_MTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51679">
        <property type="entry name" value="SAM_MT_C5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BAH" evidence="10">
        <location>
            <begin position="374"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="970"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1080"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1104"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI12896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1172" mass="130875" checksum="0F8FF9643E8F071C" modified="2018-11-07" version="1">MPARTSSTQTEWRDKKDVFVTSDMAVDDQLDDVDDSPVCRPIRIEIPASTLGTPRALFEPLDDVDAPFMSEPEALAALAQVNRDTDNDDDDDDDDDDYVAYDLDDFAVYRHHELYPLEMRSLHHLQRPGGHFFCGILSVKGENPILVKHVPIAVMPVDNYGDLSMHTVRGDIWLQSELSRRSNVYYRLGRPAKEYARFYKPSLWVADLAKHFVDFLKVMQDNKRPVSTQLFQHVFRNWLTEAHGDAPAFVEWLEQYPRADFRSAVIANISYLHKEAVGVLGERATFFHPVWSELLTFTRYKPQHAATDSRTVVTQYIYDCFEETLFQEQLIVVPMSANTERLRNRLIRDRHLELPSALDTSIMSLSTAADEQIKGIKPGDTISTHRDGELSGTKWKREVSRGFDDADRWLALVQKAHVGRDGVRVFDVIWYYRPVDTLCGLMKYPWHNELFLSDHCSCEDETCKIREDEVLGVHDVDFGGTSTTTTAEFFCRQTYIPEERKWISLGPQHMRCEHVRQGNREPPYQAGDTLLVLLKARDTISEPCELVTTVMQETQTVYQLRKLARRKRTDPRARPNELVYTDSLFECREEMVVGRCHVRFFPAGSDILTPYDRDGVGCFFYITHRQVDGGSLEPLVSAPTSLRQGFDPAAEIPRLRGFDLFCGGGNFGRGLEDGGGIRMKWANDYDREAIHSYMANVPPNETVAPFYGSIDDLQRAAIQGRFSDAVPVIGEVDFVSGGSPCPGFSRLTNDKTTTAQRKNQSLVASFASFVDVYRPKYGLLENVPGIVHKKSNRDQDVFSQLVCAIVGLGYQTVFFFLDASSCGSPQRRSRVFLAFAAPGCRLPAKPRITHAHPPWTKSQGLGMLPTGEPMAEREMPRATPFNFISAAEATADLPAIQDSRPDTCVPYPDHRVAVGMTKTQRLRISLIPRHPWGMNLARAWFGTGPGGGGSVLTEAERDFFATVRIEGITDKASSGREQTGHPRKLKSKSSTNAYGRQWPNRLMETIVTTANPCDSKSGRTLHWSEDRAISIMEARRAQGFRDDEVVLGSAATQYKIVGNSVAREVAVALGAVFREAWAESRRTGQEGVAVTQQGASGTDKACFSDSSSSSSSSSSSSSSFSSSRTSPTTSHAPWSRCAVSSAPTTPTPTVGAGKRQSSLVVKVPGPKRSRNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LF34</accession>
    <name>A0A367LF34_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prokaryotic-type class I peptide chain release factors domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_1093</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prokaryotic/mitochondrial release factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LF34"/>
    <dbReference type="STRING" id="1330021.A0A367LF34"/>
    <dbReference type="OrthoDB" id="2019491at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000004">
        <property type="entry name" value="Peptide chain release factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005139">
        <property type="entry name" value="PCRF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000352">
        <property type="entry name" value="Pep_chain_release_fac_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045853">
        <property type="entry name" value="Pep_chain_release_fac_I_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050057">
        <property type="entry name" value="Prokaryotic/Mito_RF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43804:SF7">
        <property type="entry name" value="LD18447P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03462">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00472">
        <property type="entry name" value="RF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00937">
        <property type="entry name" value="PCRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75620">
        <property type="entry name" value="Release factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00745">
        <property type="entry name" value="RF_PROK_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prokaryotic-type class I peptide chain release factors" evidence="4">
        <location>
            <begin position="271"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI13027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="419" mass="46961" checksum="77D062CAFFF30CE8" modified="2018-11-07" version="1">MHAPPWLCRSCSRAWRRYHQQQTARFVTNAPSLLLRARGLTAEYSNLKKALEATFDASSAKRVGELQRVATALRAWDEARGAMAELEILARDPSEDEDLTAIARDELAAERSKLESLERNLSVSLTPRHPFADLPCMIELRPGPGGLECRYFADTLFNMYKFLCMRRRFRFNVIKHELSDDRSSTLGESPLLEAVIEVQDSGAYDVFRGEAGMHRVQRIPGNDTNGRVHTSAAAVWVLPAFREDGGGGDDENDPGSDFFIDPSDVRVETMRAGGAGGQHVNKTESAVRLTHVPTGTVVSIQDNRSQQRNRDQAWKVLRSRIASQRVEQREAEAARLRSSILNRAQITRGNKIRTYNYVQARCTDHRAGLDVHNLPDVIQGGETLDRVMEATKKWLVDVEIQDLIASEETKPNKTGKIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFI1</accession>
    <name>A0A367LFI1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6590 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_0424</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFI1"/>
    <dbReference type="STRING" id="1330021.A0A367LFI1"/>
    <dbReference type="OrthoDB" id="3559580at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046497">
        <property type="entry name" value="DUF6590"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391:SF5">
        <property type="entry name" value="DUF6590 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20233">
        <property type="entry name" value="DUF6590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6590" evidence="2">
        <location>
            <begin position="328"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="225"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI13147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="492" mass="55146" checksum="120FC29E9CAFD826" modified="2018-11-07" version="1">MHKHKHNSKAVSHTWGPWSEWAWDESRRRWYRVRRDTNGALDYDWDNRQTPREVEQLTQDLGNLSPGSSYDAHGMASRPRRSVVTAADAYHAAAADESSYTVSKDKSKSSTKTSSSSKSKGKGHRSYDDVDDSARAPYRAVPSSSSAHHSKQYHDAKCMYSSHIPTLSYQLTLPDAGYEKSSSAYYGQSSSAGEVRTLLSKLLPLTPLALAIPLDPRATTKQAYSGGSSSRNVSSHGRDPTDEELRAAMSRSLYYAERSAAPGPSSAAYGPYYDDDDDGPPTPKAPRITADEELLEEMDPRASTRLLPHPITPNELIILPGYRVQHSSRFNPGEIFKVHWSEPEGSGNEHAPSVSGRHETQNRFGTKFYVGFRRFIVIANEPGHSICVQVYPRCKKRGLKPAKHGVVHERGHRPRLLEGEPKLGFTPIRVDMTEEGEKLSKESRVNYSKLVTVEHNVKVFFIGSVVANDWDIVQEAVNRCWSEKDHRNRRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFM6</accession>
    <name>A0A367LFM6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_0827</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFM6"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI13234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="52" mass="6017" checksum="D1BBB5455912AA29" modified="2018-11-07" version="1">MPPQHLGNLVRMDRLLPEPLFFSFCDPWKPLSFLFLCKNSPLLLCLFSPVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFZ3</accession>
    <name>A0A367LFZ3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">acetylglutamate kinase</fullName>
            <ecNumber evidence="6">2.7.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">L249_0790</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>N-acetyl-L-glutamate + ATP = N-acetyl-L-glutamyl 5-phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14629"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57936"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 19">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 19">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 19">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 19">In the C-terminal section; belongs to the NAGSA dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 19">In the N-terminal section; belongs to the acetylglutamate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.8" evidence="6"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFZ3"/>
    <dbReference type="STRING" id="1330021.A0A367LFZ3"/>
    <dbReference type="OrthoDB" id="438291at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00107"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003991">
        <property type="term" value="F:acetylglutamate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003942">
        <property type="term" value="F:N-acetyl-gamma-glutamyl-phosphate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070401">
        <property type="term" value="F:NADP+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04252">
        <property type="entry name" value="AAK_NAGK-fArgBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23936">
        <property type="entry name" value="AGPR_C_ARG5_6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd24149">
        <property type="entry name" value="AGPR_N_ARG5_6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04263">
        <property type="entry name" value="DUF619-NAGK-FABP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000019">
        <property type="entry name" value="Bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000029">
        <property type="entry name" value="Bifunctional acetylglutamate kinase/N-acetyl-gamma-glutamyl-phosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000046">
        <property type="entry name" value="N-acetylglutamate kinase / N-acetylglutamate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00150">
        <property type="entry name" value="ArgC_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004662">
        <property type="entry name" value="AcgluKinase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023013">
        <property type="entry name" value="AGPR_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058924">
        <property type="entry name" value="AGPR_dimerisation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000706">
        <property type="entry name" value="AGPR_type-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041734">
        <property type="entry name" value="NAGK-fArgBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011241">
        <property type="entry name" value="NAGK/NAGSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000534">
        <property type="entry name" value="Semialdehyde_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006855">
        <property type="entry name" value="Vertebrate-like_GNAT_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00761">
        <property type="entry name" value="argB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01850">
        <property type="entry name" value="argC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23342:SF0">
        <property type="entry name" value="N-ACETYLGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04768">
        <property type="entry name" value="NAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01118">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22698">
        <property type="entry name" value="Semialdhyde_dhC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036440">
        <property type="entry name" value="ARG5-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00859">
        <property type="entry name" value="Semialdhyde_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01224">
        <property type="entry name" value="ARGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51731">
        <property type="entry name" value="GNAT_NAGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 19" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 19" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="12 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="16 19" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="17 19" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="13 19" id="KW-0521">NADP</keyword>
    <keyword evidence="10 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="14" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="22">
        <location>
            <begin position="330"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="527"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="527"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="active site" evidence="20">
        <location>
            <position position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR036440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="RCI13354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="877" mass="96522" checksum="F6D04F5D7A791174" modified="2018-11-07" version="1">MLVATALRTGARRATAVLTLRPPLCRRALSSTRVRAWPPARDRTREIVAQTVSSIGSKREGQQYLKLFTSVSSQKFAVIKVGGAILTHHIDELCRSLLFLYELGLYPIIVHGAGPQLNRLLEEAGVEPQFEEGIRVTDAKTLSVARKLFLEENLRLMDRLDDLGVQTRSLSGVLIADYLDKDKWQYVGKITRVNKAAIEKSIEAGYIPVLTSLAETEDGRLLNVNADVAAAELARALEPLKVVYLSEKGGLFDGDDHKISHINLDEEFNHLMSQPWCKFGTRLKIRQIKELLDTLPRTSSVAIIHPSDLQKELFTDSGAGTLIRRGDKIQKITSVSDFGDVARLKATLIRDRAGLDAEATVDRWVDFLAENPFTAYFDEALQCLAIVMPPGNGRAMSTLATLTITKSGWLTNIAENVFAAIKKDYPSLVWTVSEADENLTWFFAKAEGSFNIDGSVLFYYGCDLRSEALAPVYDEFVAHGRAMLGGSNLESRLRQAAQAAAKPARVAQMQQKQQAQGYSTLVNSARRSYSLEPSQQRRGFATTNPNPPLGEKNASNTKPTRVGLVGARGYTGQALVNLLNRHPYIDLRHVSSRELAGQKLQGYSKRDITYERLDPSDVGKLNRDGAIDCWIMALPNGVCGHYIEAINESGNKKSVIVDLSADYRFDGAWTYGLPELTKRSDITSSVRISNPGCYATAAQLGIAPILEHLGGEPTVFGVSGYSGAGTKPSPKNDVEALRDNLMPYSLTNHIHEREISKHLGTPVSFIPHVASWFRGIHHTINIPLNKTMTSRDIRQMYQDRYAGEQLVKVVGEAPLVKSIMDKHGVEIGGFAVHSSGKRVVVCTSIDNLLKGAASQCLQTENMNLALGYAEFEGIPTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LG98</accession>
    <name>A0A367LG98_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5634</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LG98"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI13439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="89" mass="10390" checksum="772C170A251C96C5" modified="2018-11-07" version="1" fragment="single">CPSLKAWQKSISSRRKVKRKAVKKKVKMDKELTNREEAIKEELEAGEVFVLRRYFSRYFKVPTCSTLTYLYVRTLPRCKRCAQGGVGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGF1</accession>
    <name>A0A367LGF1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5505</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGF1"/>
    <dbReference type="STRING" id="1330021.A0A367LGF1"/>
    <dbReference type="OrthoDB" id="531564at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI13495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="142" mass="15905" checksum="AB04ADE7EA1137A5" modified="2018-11-07" version="1" fragment="single">MGPPKPPVPHVAPIYRLTATALGASMWFWTSMGALRLRSRSLISGTPHAGLRRGMKSPFLLVLQRNRLRITSLNKETVHQAPCVSAFVRKQLRASHIEDQPSIIPRNRLFVSVRLCQMRHQLLLVGHHGRQPVLTPSLSALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-05-03" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHX0</accession>
    <name>A0A367LHX0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_7994</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHX0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016859782" evidence="2">
        <location>
            <begin position="19"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI13999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="64" mass="6979" checksum="D183D8F698455BA7" modified="2018-11-07" version="1">MSVWLVFYLSLSLSLSTGFSTRLNHRPAAGPKCLCNLTSHEPFLQRTQPARGPGLASKTESDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LI97</accession>
    <name>A0A367LI97_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_8103</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LI97"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI13982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="103" mass="11951" checksum="AF6BB32B0A0CC5DA" modified="2018-11-07" version="1" fragment="single">AKVAPFFERGEEYAYNTEHFLNYLDSVSSDIIKQRCVNSICLCYSIPGHFLKSCNLYLARRPSILRLTRYNVSVRASRRELIIYSADNLPARDLVSALYYPYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIS3</accession>
    <name>A0A367LIS3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein ERB1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Eukaryotic ribosome biogenesis protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ERB1</name>
        <name evidence="10" type="ORF">L249_5952</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat BOP1/ERB1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIS3"/>
    <dbReference type="STRING" id="1330021.A0A367LIS3"/>
    <dbReference type="OrthoDB" id="5571054at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000061">
        <property type="entry name" value="Ribosome biogenesis protein BOP1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03027">
        <property type="entry name" value="BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028598">
        <property type="entry name" value="BOP1/Erb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012953">
        <property type="entry name" value="BOP1_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1 BLOCK OF PROLIFERATION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08145">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01035">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BOP1 N-terminal" evidence="9">
        <location>
            <begin position="131"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="400"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI14277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="747" mass="83394" checksum="897395B26E88DABF" modified="2018-11-07" version="1">MARLTSRKRTSDTAAQASHSEEFLGNGADDALAYSDASSGDDEFVYDHETGNISDLDAEEGSESSESEVQHRDNNDGAILPATDGPVYRITADANGGKRYEYDEIDPVYDSDDTDAQEPINTVGNIPSSFYDSYPHIGYDINGKKIMRPATGEALDALLDSIELPQGWTGLVDPQTGKPLTLTREELELLRRLQLNEVPQDGYDPYPEMVPYFTGIEEKMPLSAAPEPKRRFIPSKHEAKRVAQLVRAIKQGRILPYKPPETRQRQEAEAEEALYDVWADQEPQERHATAIPAPKLAPPGFDLSYNPPAEYLPTAEERRMWESTEAEEREKDYLPAKFDCLRKVPGYPEFVKERFERCLDLYLAPRVRKNRLNVDPNSLLPKLPSPADLKPFPTACQAVFRGHDGPVRSVSFSPDGDCLASGGQDGTVRVWALNGHQDWLVKLSTDEPVNAVRWRPNKDSFVLAAAAGEDLFLMIPPMCSAEMEKSSRDVLSAGFGFVAGEPSSTTADRKEPAARWSRPGSKLEEAGVLVKATVRAQIKTLTWHRRGELLCSVSPSGQRSSVLIHMLSKHQSQVPMRRLSGLAQAAQFHPSKPLFFVATQRKIRCYDLQRQEMVKVMQPGARWISSLDVHPGGDNIIVGSYDRRLLWHDLDFSGRPYKTMRFHAQSIRAVKFHRTLPLFADASDDGTLQIFHGKVVNDLMESATIVPVKMLRAHSVVDNLGVLDVDWHPRHPWCSSAGADGTCRLWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIU8</accession>
    <name>A0A367LIU8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">TRAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_6067</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIU8"/>
    <dbReference type="STRING" id="1330021.A0A367LIU8"/>
    <dbReference type="OrthoDB" id="10250660at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030697">
        <property type="term" value="F:tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009451">
        <property type="term" value="P:RNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000201">
        <property type="entry name" value="TRM2p tRNA methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030391">
        <property type="entry name" value="MeTrfase_TrmA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002792">
        <property type="entry name" value="TRAM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025795">
        <property type="entry name" value="tRNA_(uracil-5-)_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061">
        <property type="entry name" value="RNA M5U METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11061:SF30">
        <property type="entry name" value="TRNA (URACIL(54)-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01938">
        <property type="entry name" value="TRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05958">
        <property type="entry name" value="tRNA_U5-meth_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51622">
        <property type="entry name" value="SAM_MT_RNA_M5U_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01231">
        <property type="entry name" value="TRMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="TRAM" evidence="7">
        <location>
            <begin position="74"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="541"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="551"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="492"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="492"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="416"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI14341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="574" mass="63245" checksum="3DF57D8723A8C521" modified="2018-11-07" version="1">MASSSGPMARASASAGKRTSSSASKRPKRTKRERNMGEGSADQVLRFDVDALLSSVSPEFWEMDPQGDPGLRKAFSEIEVDIVDISANGDGLGLLPSQPNHVYIVPFTVPGDKAKIRIIHPGMSDHHSTADLVAVVKPSPLRSDYRARCRYFGHCGGCQYQMLEYSEQLRLKRLVIVKAYRYFARLPDHLIPPIGETIASPLQYGYRTKLTPHFDGPPSATRRPHKKNRQGEPRPAFEACPDIGFLRKGRRSVMDIEDCPIATAAIRRGLKRERERMRNDFVHYNRGATILLRESTSRYDDDGSVPNPPDPNALRVEGDGFVDLKTCETDSKAITTEYIGKHIFTNPAGAFFQNNNSILPVFTAYVRDNILPPSASSSSSSTPSADSPFYLIDAYCGSGLFTVTLASLFTYSTGIDVAADSIESARSNAALNGLTEDRCRFIAADARDLFREIEYPPDRTAVVLDPPRKGCDGDFLDQLTRFGPRRILYVSCNVNTQARDVGCLVRGKAGGAAYRLRSLVGFDFFPQTAHVEGVAILDRYDGEDESGANGRRNDEANSSDRHGDKDAQESTPKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJ69</accession>
    <name>A0A367LJ69_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJ69"/>
    <dbReference type="STRING" id="1330021.A0A367LJ69"/>
    <dbReference type="OrthoDB" id="5404794at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="449" mass="49652" checksum="F076FDBB9F6FAACC" modified="2018-11-07" version="1">MPPAEIADSDDDDNGSDSPFAPENNELITVSAQTRSSDRTSHATASTDPILFQTVFDEQREAAHQSALKDAFYPTGSERCHENTSSASIELLAAPDAWSSTNPGERQCSTTKRKTEGAAMVEAKDMWDVPSSPERNPGSSISRTKSRQATTIKITRGLRRNVEMLGYESDEDAGRTRRDTKRRKSQSSTDDDLDTPIKDKKSPNAVTISTMNIDDQQHPLCIATKPLSESQKEEYESVRGSQTNTMAKEASDSKRQHSSGTATNFNTPRVNDPSSHEEGGGLTQVKRRTRARRDSSPDVITLDRGGDEVQGCDASSQGDHVDMPSRRQDQQDDDESDFGESMVKERQKKKRGRPPKKMVASEPLKAKRGRPKKKKKKTEEQGGERALEETIATEDPKPPEETKKQDAALTTKTASPQPPPPPLSRNKPLYRVGLSKRLRIEPLLKSLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJI4</accession>
    <name>A0A367LJI4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6164</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJI4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="94" mass="9952" checksum="E1229CCC32DA9B63" modified="2018-11-07" version="1">MPMSKAEEKRKEDLLMRVGRGRELLAMDGGGMTYAYSSSSPPSRGGGGDDEKSVYVPARTDMMLSISISISATSSYMCISGHVLLGRDAPCTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJT3</accession>
    <name>A0A367LJT3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA mismatch repair proteins mutS family domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_6950</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJT3"/>
    <dbReference type="STRING" id="1330021.A0A367LJT3"/>
    <dbReference type="OrthoDB" id="2534523at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043504">
        <property type="term" value="P:mitochondrial DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001238">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000042">
        <property type="entry name" value="DNA mismatch repair protein Msh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000010">
        <property type="entry name" value="DNA mismatch repair protein Msh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF34">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="8">
        <location>
            <begin position="857"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="42"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI14660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1016" mass="112149" checksum="D66E122E64F70E8B" modified="2018-11-07" version="1">MFRPRRLDGLRRAIHTIGRPVLSGAGNRSVVVVPARGKKTKTTVKMSELPQGPIRTESVPTLPLEPAEDDSRGPPYPTVILQAWRNMRKFDNCILLTRVGGFYELYFEHADEYAPLLGIKVATKKTNAGPVPMAGFPFFQLDRYLKILVQDLNRYVAIAEELHIDAADKVKLGGLMRDRKVTRIITPGTLIDENFIDPYANSYVLAIHVCQDETPLAETDAQVETEAIDCDIPALPVVGSVPLGLAWLDLTTGHFFTQSTRMQSLSAVLSRISPREVVVDQDLQQHEDHDLLTVLAEDRHFITYSPQGTLANVSDWTPLLEEEVPESTRSSFTDEEVLAGGMLLSYIKDRLQGMAIKLQPPRRHQSMDVMSIDKNSMRALEIKLTMRDGLFRGSLLHAIRRTVTKSGARLLNEWLGAPSTSIEIINQRLDLVSRFIAAPELRDSIVQLLRRSHDSQRLVQKFAMGRGDADDLLALANTVRATEDLVALLTQAARSESGSEPDCLDPLASRISLEEPVKLAQRIKDAIDEESVIYQHKLEESEASDLMVLAEGVVASEGSQEDASLLPKCRKKRPTTLREYYGEDNEAWIMKPAASSVLEQLHDKLNGLAAEKDTLEQSLGEQLGASSLSLKWNPGLGHFAHIKGKDVKKLTDVKALSVSRSTRSFHLPEWTALGQRMDQARFRIRREEQRVFQSLRQHVVLNLVKLRRNSVVLDELDIVTSFAKLAVEHDLVRPGINDSTGHTIIGGRHPTVEGGLVAHGRTFVRNDCLVGPPAGGLVWLITGPNMAGKSTFLRQNALITILAQIGSYVPASYAEVGIVDAIFSRVGSADNLYRDQSTFMVEMLETAQILRQATSRSFVIMDEIGRGTTPEDGAALSYACLHHLATANRCRTLFATHFHDVVDLAARDGLLLGHHHHHHHPDDSDSSNDSNNAFRGGVAPVQTYCTDIEEDGKGGFVFVHKLRKGVNRRSHALKVARLAGLPERAIDAAQRVLAARNAVVSVGDADANKGVANAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJV0</accession>
    <name>A0A367LJV0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">DNA topoisomerase</fullName>
            <ecNumber evidence="3 7">5.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_6451</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13 14">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="3 7"/>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJV0"/>
    <dbReference type="STRING" id="1330021.A0A367LJV0"/>
    <dbReference type="OrthoDB" id="430051at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.290.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.140:FF:000005">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="entry name" value="Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="entry name" value="Topoisomerase I, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="entry name" value="Topoisomerase I, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390:SF21">
        <property type="entry name" value="DNA TOPOISOMERASE 3-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PROKARYOTIC DNA TOPOISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="Prokaryotic type I DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52039">
        <property type="entry name" value="TOPO_IA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="9">
        <location>
            <begin position="2"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IA-type catalytic" evidence="10">
        <location>
            <begin position="166"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="530"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="539"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="562"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI14715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="663" mass="74110" checksum="CB039F4AE34DCCAF" modified="2018-11-07" version="1">MRVLCVAEKPSISKAVSGHLSGGRVQTHNTRSRFIKNYSFAFDFAQAWGQCEVTMTCVAGHLTNVDFPSEYRNWSHPPPETLFTAPIITNIHDDSKIIAKNIQDQARYSRLLVIWTDCDLEGEHIGQEIVDAARQGNSGIQVKRARFSNVERAHVLSAARRLADLDENKVNAVKARIELDLRIGCAFTRFLCNSLRPLGGPMEKLTLSYGSCQFPTLGFVVDRYFRVKNFVPEPFWSIKLTHTKQGKTVVFGWARNRLFDRTTTVILYERCLAAKKALVTQVQEKPTRKFKPLPLTTVELQKAATRLLRLNSQQAMNIAEGLYNKGFISYPRTETDRFDKGIDLRALAQKQTASQEWGQFAQGLVDGAFQQPRQGRHDDKAHPPIHPIAYAAPTVLSADEARLYEYVARRFLACCADDAKGMATDVDVEYGDERFHARGVIVLERNYLDVFIYDKWDNTAELPPFSRGEWFEPTEAMMTEGKTSPPNYLTEADLIALMDANGIGTDATMADHIQKIQDREYVAVIDRARNAEPGDGDEMTGGGSEAGAGRGRGGGRGRRGGRGGATSTGRGRGTQKVFVPTQLGVALILGFDRMNFETSLGKPFLRKEMELKMKAICEGNVTRDMVLRESISQYRHVFFQSQEKLGVLRAACREFVFGQPAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKL7</accession>
    <name>A0A367LKL7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKL7"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="135" mass="15310" checksum="06738F9817BE3BB0" modified="2018-11-07" version="1" fragment="single">GYSGHSARIDSLQRSSQRSARCTYSGHSTRLISAQGSRHIDRRAVLIAVIALDQSSQRNRHSDRRAVPIAVIAPDLDSRTKFIISFNFITSSIQSPLLPSILLQSSQNHHHVIRLLLLYHVIHTLITHHHFHCRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKP4</accession>
    <name>A0A367LKP4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_6845</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKP4"/>
    <dbReference type="STRING" id="1330021.A0A367LKP4"/>
    <dbReference type="OrthoDB" id="5344325at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF84">
        <property type="entry name" value="FUNGAL SPECIFIC TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="20"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="575"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="622"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="576"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="658"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI14970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="818" mass="90454" checksum="916C7D5A7DB274B6" modified="2018-11-07" version="1">MATSAASASLDPASGYNRSACTECQRRKQKCNREWPCDRCQRRKIADECRYNYSSAPPVSSSANAFVPLAPASAIGHGRPDEQPRTIVAEAEPVSALSPPSSGPDAPGFDALAAARLLNNLGIELKVPMQRNQADRYLDTDVPFYQTKPSETASKEDLAAEDATPQMQRVLELLPQRQTMDKLISDFTHNINYHYYIIYPPDFLRCYHIWWERRSKSKPIALQYTALLAMICACCMQHAENEMQLELRRASGLSAEDLSEQLQSAVRELSSVIPVGHFHMHNVQRLLHSCYWYKAEARFVEAWHVLSAAIREGQELEPPEGTETEHEREMRRRLWCILDTWDWQISSGLSRPKIIDRDDCDAELPSLTLERFSSRTPSPLLHMKMQSELTRQLASRFSAPKNIIDPTEVLEYQALIEAWMRRFPAVYDFDHPDLSCDAQYPWVFPHRYYVYTMACLLILNPIRHYMVRSYTPSSPSVELGIHATGVAYSLKLLRTLRSWVDAIVHRDGRLHFIVFSIFDTAAILCTAIIKDGHNMLAERDEISRAIADALAMLRRLNSISRTSRTSYELLERLVRRLPPSSRPKQQQQPQRKRTKMATGVPAAASASAGVMMPCSGNGINQLDLAPTPPANHTHQCHRHHWQHQVSPPPPPVLRSNHAPLGSLPQALGGASLGPPGGPLVSSTSPSYPSSSASDCTSPGVDDRMLTSLSSPEVSAVVSHGVGLPLPPSTSALATCGFVSGEDEAQVSPPAFELETVTQAQLGELAPLWNWHSENLDIVSSMGIVSARPDVVAVAAPLGPATGFSSSPGTCEGGGRAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LL16</accession>
    <name>A0A367LL16_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_6826</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LL16"/>
    <dbReference type="STRING" id="1330021.A0A367LL16"/>
    <dbReference type="OrthoDB" id="10251574at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097373">
        <property type="term" value="C:MCM core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17755">
        <property type="entry name" value="MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000217">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008047">
        <property type="entry name" value="MCM_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF66">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21128">
        <property type="entry name" value="WHD_MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01660">
        <property type="entry name" value="MCMPROTEIN4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="604"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="180"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="325"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="555"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="122"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI15101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1024" mass="113107" checksum="56060D913889E7D4" modified="2018-11-07" version="1">MSSPSNRRQRSSPSVATPRRSTRQSSQLASSPLMFPSSEDDQHDQQEQHQRDDAQVSSPLRQASDSQMTAGRAPIPGSPLRQMTDSQTPRLDDDDDDDDDREATPRASGRSARESSPIRYDPSSSPGRSFRQQSELGGENFVGSQRNASAARRRGDINSDSIRTPRAPRRIILDEAGRVMREGQTPGSDAASFANRDPNTSEADALGGQGETLIWGTTVSVNDTFAAFKDFLRNFKQKYRMYRDGLSVEEAAAAPDAESKPYWEALEAMWMLSSTRLYLDIADLNLYPPTRKLWYQVQAYPEEVIPIMDQSVHDMMMEIARVDTARSRPSNGNPPETPQGTQNSDALFFPSSDRPEDTATPRPPQDQHMSEDEVAASVYVVRPFGLDSTINLRELNPSDMDRLVCIKGLVIRTTPVIPDMKDAFFRCNVCNHSVNVGVDRGKIREPTQCPRQICESKNSMQIVHNRCTFEDKQVIKLQETPDAVPAGQTPHSVSVCVYNELVDYCKAGDRVELTGIFRVSSMRVNPRQRTLKSIYKTYVDVLHVQKANRKRMGADLSTLGIEGEREAEEKGGDDDDDKNRPEETRAITPEEEARIRETATRPDVYELLARSLAPSVHEMDDVKKGILLQLFGGANKTFSKGGSPKYRGDINVLLCGDPSTSKSQLLSYVHKIAPRGIYTSGKGSSAVGLTAYVTRDPETRQLVLESGALVLSDGGVCCIDEFDKMSDGTRSVLHEVMEQQTVSVAKAGIITTLNARSSILASANPIGSRYNPDLSVPQNIDLPPTLLSRFDLVYLILDRFDEKADKKLAKHLLSLYLEDKPHSAPTSRDILPVEFLTSYISFARANVQPTLSSEAARKLVECYVDMRALGHDVRSAEKRITATTRQLESMIRLSEAHAKMRLSDTVTADDVAEANRLIQSALKTAATDAQGRIDMSLLTDGSTAADRQRRSDLRDAVVRLLDEMTSAGNAVRWGDVARRLAEGAGVPVEPADFSDAMRGLEAEGAVTITGEGARRTIRRVTAMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LM72</accession>
    <name>A0A367LM72_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome biogenesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_3579</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in ribosomal large subunit assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RRS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LM72"/>
    <dbReference type="STRING" id="1330021.A0A367LM72"/>
    <dbReference type="OrthoDB" id="28455at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007023">
        <property type="entry name" value="Ribosom_reg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04939">
        <property type="entry name" value="RRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="144"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="144"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI15536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="195" mass="22162" checksum="0D92DA6D4314EE14" modified="2018-11-07" version="1">MSLPSSRPKLPVAVEKPTPYSFDLGRLLAQDPNAIVLTASREQSLAEVARDGAQALINQLLTTCPLTSTAADGVLLTLPPPSTPMPREKPVPEARPPTKWERFAAKKGIRPKTREQRKNLVYDAESGEWRRKWGYQGLNKKSETDWLVEVDPKKEKDRKEGTTPRGDARRERKERIRRNERKMRKNERLAAEKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMC4</accession>
    <name>A0A367LMC4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like-conjugating enzyme ATG10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Autophagy-related protein 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_3496</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMC4"/>
    <dbReference type="STRING" id="1330021.A0A367LMC4"/>
    <dbReference type="OrthoDB" id="4089664at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061651">
        <property type="term" value="F:Atg12 conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007135">
        <property type="entry name" value="Atg3/Atg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14957">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14957:SF1">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03987">
        <property type="entry name" value="Autophagy_act_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI15559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="245" mass="27378" checksum="BEBB552640D49D6C" modified="2018-11-07" version="1">MADDIKHFPSLDRLEFSAACHHLERRYRQATLGPLRSRWKLRLCTALDAAFTVDGTYATYAQIKRPLEPTTDCHGLSLAMERVSFDEEDSEIIRAEESDSVRGASSTHSLCPDQYIQAAIVKDVPHDDAAHVIYEIHLHPTYRVPCLWFTLHNLSVDEPALSIETVFRRLVPDEYKSRLRGVGAVGGISADHHPITGLPAFFVHPCLLGDAISGFQCSLDNYLIIWLGLVGGCVGLWVPREMALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMI9</accession>
    <name>A0A367LMI9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_3580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMI9"/>
    <dbReference type="STRING" id="1330021.A0A367LMI9"/>
    <dbReference type="OrthoDB" id="2419400at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000028">
        <property type="entry name" value="WW domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043904">
        <property type="entry name" value="PhoD_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689:SF2">
        <property type="entry name" value="WW DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G06520)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19050">
        <property type="entry name" value="PhoD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="411"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="360"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI15656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1162" mass="126438" checksum="F93DE79E904056CF" modified="2018-11-07" version="1">MEATRSVPDKDKFLSKPDSPTVRPLRIFKSQSPGPVARTDASTSLPSFPLPPGASSSAAPLPLPDDDDVCKPAHAKSSNNYAATGTRIDTNIAEKRPGLAERRGASPKVIHSPSSPEAEGQYLPRPLKDPGSSNPGRPHQTYYPPPAAGPALFSVSDSRLSDQHLRSDDQCVNRFASTASNYTTKATRGSPPPPATPIAEPGAVPGGGIEARYAASGISGTATLNSLQAQTAAASQRLPQYGSQPPQPQRPWTPTESPGQAPSGPPTVYQGTTPISSTGVRLTFSPPPDQPTNKDGNPALQVSVLEQDFQRMGTKTPPPAYSKVNPSRGSPRAREKQRPQQGTSEADPSQTSPPSNKPVASAAPATAMASPALQHPGHPAFANDPRPEANGQTLEAVPAASPPVPTPASPPPLPEGWFASLDQNSGQYYYIHFATQATQWEFPKGPNPIQHEQTPLSPTASTYGNPLTSPMFVKQPMASPMFTPHTPGGYAESIMSVAASQAPSTAGFSGPPPSSGVSMYRVQPTNGVYFGPYLRYVNMDVEKGTWYGSIMIVTDAPQPPTIHIHLSVDLSPNPRQLQPRAVYVHQRWTFYRYEVDLQMGENGTERWTYAVTSHLGCTRYEFVVAGRHETGWRFIAHSGNDFASNTTQNERARLGGVGFMWKDVLQKNVDCGGFHAQLGLGSQIYADRLWKEVPLLKQWLAMSGRDNKKNAQWTARHEEDVTHAYFHFYTSHFDQPFLREAFAQIPHVLQINDHDIFDGYGSYPPYMQAWAMFKNIGRIATDMYLLFQHHTTVEMMRNVSTDLDIFTVTGVGWHFVKFLGPALAVVGPDCRSERTQARVMAGPTYQGIFPRVAMLPPSIQHVIWMISVPLIYPRLDTVESLANTVAAGKKAVNTTYNILGKVTSSMAGVVGGKEVVAQGFTQVKKAVGKTGLMGHVLNQFGELDIQEILKDMWTHESKDLERTYLVRTLQGIAQQKGIRMTFLSGDVNASGAGLVHDPTHPGDHKTMYQIISSPIVGAPQGGYVSKLLHNQKTLYVPLNGQRSTHEVSDTKEDMMEIFHTDASGATRELKKLMNRRNYVVFVTFDQEAATQTPFSPGASQMPLSSGASIGDQQQQQQQLVLHQQQGLSRLGLAVDFVVQGDGAYQATTKYGPVIIPHLEYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LML2</accession>
    <name>A0A367LML2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Clp R domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_3454</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LML2"/>
    <dbReference type="STRING" id="1330021.A0A367LML2"/>
    <dbReference type="OrthoDB" id="47330at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19499">
        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000120">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000025">
        <property type="entry name" value="ATP-dependent Clp protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000010">
        <property type="entry name" value="Chaperone clpB 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF176">
        <property type="entry name" value="HEAT SHOCK PROTEIN 78, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="112"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="513"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="domain" description="Clp ATPase C-terminal" evidence="9">
        <location>
            <begin position="691"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="325"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI15492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="788" mass="87106" checksum="F684230927AEFE17" modified="2018-11-07" version="1">MQARKQLITSAQRLVGASTRSARPLARLGTGQIARGTLLRLTPTISVRNYASGRPHPPGGTHRMNLGGEAEKPALEQYGIDLTARARDGKLDPVIGRDSEIQRTIQILSRRTKNNPVLIGNAGTGKTAILEGLASRIIRGDVPESIKNKRVISLDLGSLIAGAKFRGDFEERLKKVLDEVQKAEGEVILFIDELHTLLGLGKAEGSIDASNLLKPALARGELQCCGATTLNEYRQIEKDVALARRFQPIVVSEPTVEDTISILRGIKDKYEVHHGVRITDGALVAAATLSNRYITDRFLPDKAIDLMDEAASHLKLQHESKPEEIMRLDHKIMTIQIELESLRKEKDVASKERREKLEKDLKKFYDDISHLNARWDKEKAEYGAVKKIQEELDKAKFELEQAQRDGNFGRASELRFGVIPDLEEKLPKEDGSARQDGEEPSLVHDAVDSDDIAAVVSRITGIPVSKLTSGHIEKLVHMEDSLRDKVKGQDDAIKAVSDAVRLQRAGLSGDNRPLASFFFLGPTGVGKTELCKKLAGFLFSTESAVVRFDMSEFQEKHTVSRLIGAPSGYVGYDDAGQLTEAVRRKPYAVLLFDEFEKAHRDISALLLQVLDEGYLTDAQGHRVDFKNTIIVLTSNLGADILVGQNALHPYKENAKGEMDASVRDAVMDVVGRAYPPEFLNRIDSFIIFKRLSRDAIRSIVDIRLSDLQARLEERRIKLSVPAKARDWLGDRGYDPKYGARPLNRLITNEISNGLADGIIRGSLKMGQTAEVAVREDQKGLVVAAAEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMS9</accession>
    <name>A0A367LMS9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_2824</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMS9"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI15753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="131" mass="15070" checksum="DEE2552FE5BB0B60" modified="2018-11-07" version="1">MSLRLSCHRQQFPGRDVLLLLLSSHQHIGEHLSWTEKLLGINHAGRFVLTPLLWPRTDMPSIFVFFLSLHLTAPPWDTSRRPSFMQPHVPWPLWLEPLFSARYASALREMAPKGGGGFVLLVRVTADYFRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMV6</accession>
    <name>A0A367LMV6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial import inner membrane translocase subunit TIM23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_2978</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMV6"/>
    <dbReference type="STRING" id="1330021.A0A367LMV6"/>
    <dbReference type="OrthoDB" id="159299at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045238">
        <property type="entry name" value="Tim23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371:SF0">
        <property type="entry name" value="SD19278P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15371">
        <property type="entry name" value="TIM23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="44"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI15783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="469" mass="51288" checksum="328AEE04F31456C0" modified="2018-11-07" version="1">MPCCTFYHRPRSLSPSILDIHFSAHRLSRPSSWPRLPPTMSSLWNALTGTSKSSQTQAHPQGQSQSLPPTGLSEPAEASSFAVSLTPGTDAYLQSSTFADPSLLHPLAGLDKGTLEYLTLDESVLSDLPGGQSVLPSRGFTDDLCYGTGITYLTALSIGGAWGLQEGLRRSDGQPPKLRLNSVLNAVTRRGPFLGNSAGAVAITYNCINSLIGYVRGKHAASNSVLAGALSGMVFKSTRGLRPMMISGGIVGSVAAVWAIFRRSFFPVPDRSVPQQTFVGRYPMGGGGKWRVYITARGQRGLDGSGRGVWVYNWIHLQRMRGVARPCRYDHVNDMSFAYLVRVNGDLGPHSPSPAMCLPCFPWTWTQYDDPLDSLPQPRVWKREGSSWALVKAPCQLPEANASPPSIFSSHHTPPPPLLLLPSAPSSHIFFFPILHRFEHLKLEPYPPFHIPSSLPTPYERSQRTKYKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LN29</accession>
    <name>A0A367LN29_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ADP-ribosylation factor GTPase-activating protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_3583</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase-activating protein for the ADP ribosylation factor family.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LN29"/>
    <dbReference type="STRING" id="1330021.A0A367LN29"/>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08204">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07608">
        <property type="entry name" value="BAR_ArfGAP_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000051">
        <property type="entry name" value="ARF GTPase activator (Csx2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000252">
        <property type="entry name" value="ARF GTPase activator (Csx2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000017">
        <property type="entry name" value="ARF GTPase activator (Csx2), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045258">
        <property type="entry name" value="ACAP1/2/3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180:SF160">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN EFFECTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23180">
        <property type="entry name" value="CENTAURIN/ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16746">
        <property type="entry name" value="BAR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="637"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="domain" description="Arf-GAP" evidence="8">
        <location>
            <begin position="823"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="38"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="526"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="606"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="747"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1061"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="526"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="622"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1078"/>
            <end position="1087"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI15652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1105" mass="121323" checksum="6A3DA074C41FA973" modified="2018-11-07" version="1">MGNVSSRPDDGAALFLRDQNRLAVSSLVITNGRKRSSLNILPNASPASRLSVSRPTGEASPIEYVQDPEPSNPANTPSFLLKLSGDDELIFTFTLVMRQSQSPSSSNVDAAASAQSDTSISGLTFVCASTSREVENLVTREFHADPNLHKNANVDLVGDYGTNGSPSKSFEWTWKWKPPKAVEDRGGGWRNSCSFVEYDSRAHRLLTLASFSFWVSSTSVTLSHPGSPSPPFLLASPPKIRVASAHSVDSRLTAGADVDEPVSPLLPPNEPAVPPATPLAKEPVKVDVSCPKPGDDVTVSDDGPVFRATLKALEQKTGSMRTQIKKLLKRAEQAHSNQIEANEAFHAFMDALREASSTNANAVQPALEHYFDNIARQVLSYEQQSTTNLQRIIIDPLNRLYQLDIKQAESKKRDFEEESKDYYAYVSRYLGQRQDSVKAKKLAESDSKYQNKRRNFELKRFDYSSFMQDLHGGRKEQEVLSHLTKYAETQTKGFLDTAKKVEDFLPQLEALSTEVQVADKEYQYRRREREEKRRGLEKSNTPYMEPEQASLSSTIPAILNGNAGSTSDSELGRADSTGSQVKNAIPIGAVQTVAAHGMELSRSPGSLTQNAMGSPAPSKFKGFRDLEERDSSQATASQRKEGLLWALNRPGGHVDPRTLNKQGWHKFWIVLDQGKLSEYSNWKQRLDLHIEPIDLRMASVREARNAERRFCFEVITPSFKRVYQATSEDDMNSWIVSINSALQSAMEGRAGHERAGHAQGSGEMSGQRDIGSILTGKTHSAGHGASPPHHAGTGSVLPSRRITVGARPTMVRTSSSGYDENPDKLLQMVRDADQGNCWCADCGSGSKVEWVSINLGIVLCIECSGIHRSLGTHISKVRSLTLDIKSFTVDIVEMLLLIGNRVSNMIWEARLDPAGKAGPQATREQRLKFITAKYVERAYVEPISSTLSRFGTADETLLAAIKKNEIQQVLYALALRANPNVVDRMRGTHAIWLALAAADPASPSPTPNVSAAEREDKTVPFPVAELLTQNGAEMPAWLPAFPLGRFAMQYYEQKLGKGNGGAGDGLSSLPANAGANEKLQREREARLQKRVSTGGRLAKSPIPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LN76</accession>
    <name>A0A367LN76_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutamate-rich WD repeat-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_2481</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LN76"/>
    <dbReference type="STRING" id="1330021.A0A367LN76"/>
    <dbReference type="OrthoDB" id="2161379at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051972">
        <property type="entry name" value="Glutamate-rich_WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903:SF1">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="8">
        <location>
            <begin position="97"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="305"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="350"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="400"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="160"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI15837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="493" mass="54310" checksum="354DF712FA10D02F" modified="2018-11-07" version="1">MSKRKSDVENGHGLRLKSGDRPEKMDMDVENMGEFEDDFEDEFESEDDIMEAGVDGRPDAEREAEEKTEMDVDQAIFIVGRSKLEPGQTLAPDLDSYHMIHNLSTPWPCLSFDIVRDSLGDNRKAYPATMYTVAGTQADSAKPQDNQLLVNKLSGLGKMARQHVDESDGDDDDDDDDDDDEAEPVLESKSIPIGSTTNRIRLHQIPSDDPARPPTTLTATMTESTKVLIHDVTPHLASFDNPGTVITAQQNKPISTIKMHKSEGYAVDWSPTAASGKLLTGDNDGLIYVTTRTGGGGWVTDNRPFQGHAGSVEEIQWSPSEASVFASASSDGTVRVWDVRSKSRKPAITVQVSSSDVNVLSWSRQTTHLLASGADDGVWAVWDLRQWKASSDKPQPLASFDFHKEQVTSLEWHPTDDSIMAVAAGDNTVTLWDLAVELDDDESKDTAGVQDMPPQLLFVHYLKDVKEVHWHPQITGSLVATGEEFSVFRTINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LND4</accession>
    <name>A0A367LND4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_2751</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LND4"/>
    <dbReference type="OrthoDB" id="73788at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3970.10">
        <property type="entry name" value="BSD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005607">
        <property type="entry name" value="BSD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035925">
        <property type="entry name" value="BSD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051494">
        <property type="entry name" value="BSD_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019:SF5">
        <property type="entry name" value="BSD DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019">
        <property type="entry name" value="SYNAPSE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03909">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00751">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140383">
        <property type="entry name" value="BSD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50858">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BSD" evidence="2">
        <location>
            <begin position="232"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI15762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="395" mass="43468" checksum="B71D6F6EE7803C3B" modified="2018-11-07" version="1">MDLSYDFIQDDQAGSSKSSNPDQPQASLESDLQDAYKAISTSTWGLKIGGFIGNVVKQGESVYSQAQKELAEVGEDASKGFTDLRDSIMNRTRSLTQTTVREAGPKDADDSESTTTISKATSSDDAAQQPETVLSLLRAEAAKRLQDLQRAEDAADEALLRFGGNVRDFLRDAITIAPPEEASQDTTVLFESKDAQGKRVIHTSRFDAQLHVIQTSADRFTEDQSGAEYDTWASGFDIDSKTEDISADLAKYPELRTTMEKLVPDRVSYADFWRRYYFLRHGIETAESRRRDLLKAASAEDEVGWDDDDSDDEAADVNKPVKTKTASVTSSTTIQPRNQAQEKPTESRKSNDEKSVADSSEASYDVVGAASAKTSQAPSSPKESKRTEDSDDDWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNJ4</accession>
    <name>A0A367LNJ4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_2993</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
            <orientation evidence="1 12">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the small Tim family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNJ4"/>
    <dbReference type="STRING" id="1330021.A0A367LNJ4"/>
    <dbReference type="OrthoDB" id="1551503at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050673">
        <property type="entry name" value="Mito_inner_translocase_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13172">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM9B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0143">Chaperone</keyword>
    <keyword evidence="10 12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Tim10-like" evidence="13">
        <location>
            <begin position="21"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI15988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="95" mass="10918" checksum="3AE62A13357117C6" modified="2018-11-07" version="1">MDRQVIQPSALSSAEQRQLEQRIQKRQIKEFMGVFGGVVEHCFISCVDDFTSKALSSRENGCISRCVGKWMATQQRLGERFQEHNAKLAQQMQNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNQ0</accession>
    <name>A0A367LNQ0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNQ0"/>
    <dbReference type="STRING" id="1330021.A0A367LNQ0"/>
    <dbReference type="OrthoDB" id="5430106at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22794">
        <property type="entry name" value="THAP DOMAIN PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22794:SF2">
        <property type="entry name" value="THAP DOMAIN-CONTAINING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="546" mass="58045" checksum="03E64CDC849ECF9A" modified="2018-11-07" version="1">MARDGEDDGAGQSKRSALNHRDTDLAHNTPAPPAHPSRKKHHHVGRLHARVPSSKAISKQVGHGTKLTRPDAATTTTTTATTAITPNTTAAAHRRVTSEVRLPSRASAGNVSKSASHTSLKRNRSHVEVTKHNHSSDKLKRTASGSGIHHNHRHKTSKSQVHFDLGSEDPDEDEWVDASGFNSPHLSRKPSLNSCGQSSPLRPALSNLSARPDSRALPAQPCAPSSPDRETSHHKAYLTSRLLQRTPSQGAPPKMTVDFAQAARPQLSVSHSTDMDVSPLTASNSGELTSRFVDIPGSTIASHGSFYCPPGASDQAALRLSTATAALACDAIDTTPSTDNDDSVLVPRSARRTGALPAETSRVQQKLNLQRASSVLEPGQAVTGVGGVVGTSPLIGIGGSSFESSRDPRVGKLLERTGMEYLVVRRYQNPVSRSINRLGRSLGWDSNRRTPRGTPSSMNGHNKHMDVTGRHSRNASTPEPRLGIVARRPASVRTVGTGASFEGDGVSRLSERLSGPSVVGTEEEDGTTALLRSIWDRSMDLGAGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNU6</accession>
    <name>A0A367LNU6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aminopeptidase</fullName>
            <ecNumber evidence="11">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L249_3211</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="11"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNU6"/>
    <dbReference type="STRING" id="1330021.A0A367LNU6"/>
    <dbReference type="OrthoDB" id="10031169at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000001">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF171">
        <property type="entry name" value="AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="14">
        <location>
            <begin position="12"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="12">
        <location>
            <begin position="253"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="13">
        <location>
            <begin position="545"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="326"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCI16114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="887" mass="99097" checksum="70B93A1618F6FC24" modified="2018-11-07" version="1">MADRDILPDNVKPLHYRLSLSALDFVAWTYKGTVTIEAEIVKPTRSIVVNALELKLFRASVTVDQAKSSQAFETTDIAYDARAQRATMTFKDELPVARRAAVVIEFEGVINNEMAGFYRSRYHPSISPPDSVAVPHDDDWHYMLSTQFESCDARRAFPCFDEPNLKAAFDLELEVPSGLVALGNMPVRAERPAARDGFKIVSFETTPVMSTYLLAWAVGDFEYVEALTDRRYNGKKLPVRVYATRGLAEQGRWALEHAHKIIDFYSEVFAIDYPLPKADLLAVHEFTHGAMENWGLVTYRTTTVLFDERTSDGRFRNAVAYVVAHELAHQWFGNLVTMDWWDELWLNEGFATWVGWYAVNHLHPDWEVWAQFVNEGMEAAFRLDGVRASHPIHVPVRDALDVNQIFDHISYLKGCSVIRMLANHLGVDVFLSGVSRYLGAHAYGNAKTEALWRALTEASGQDVAALMGPWIGRVGHPVLTVAEEPGQVTVKQSRFLSTGDAGPDDDSTTWWVPLGFEGRSGEAGVVPGLSLKAKSETLRDVDEDFYKLNSGATGFYRVNYPPTRLARLSTQLNRLSAEDRIAIIGSTADLAFSGDGTTASLLTLILGFRSETHPLVLTQLLDSLGSVRSIFGGDAELRRGINEFERQLIEGKVREVGWESAPGEGYLAGIVRKYLIVAAIDSQHKETIDEALRRYDGWVVDAEKNPIPPSLRLAVWRSAVRRDPGPAVEVLKKEWATTKSIDGKTICLQAMAAAEDKEVVEKDILAFNFGTSSDDVPAADMHVLGLMMADNPPARDWQWEYVKKNWDACVAKLGNPIVVDRFVRMALGGFVDDSAVDDMDAFFRDKDTTAFNRTLATVTDRVRGRAAYRRRDAPSLREWLAARGYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNY7</accession>
    <name>A0A367LNY7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_3266</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNY7"/>
    <dbReference type="STRING" id="1330021.A0A367LNY7"/>
    <dbReference type="OrthoDB" id="5411678at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="382"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI16119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="462" mass="46962" checksum="9EB4CC3A3F5074E9" modified="2018-11-07" version="1">MQSEPELDNMRSGANRSAQFQEKRPSSSRFSTVTMSGRTSQAPTSAAVESPTSAAAAQPTNNEAAASSAAPSPSSSPPSPSPSANSSTPPVAGSSLAPSSPSSSSPQPSQTEERPPPVATQTTATTTTSSSPPQHAAPSPTPSSTASAQPSAPPAAAAPSSSSSQQQPEASPAVVTVTPSNLATSVQVVTSTTTRAPAAGPLTTSSRPPSSTSGAAAIDTSASGSGLNQASRVAIGVVVPIAAIAFLAIAGLFWWKKRRARQEAEEERRKEVEDYSYNPNADPTMPTVEHAYEMKDDGGYRGWGSTATATTGSRGRKASTTMSGGAAGTYSDPASPVRANLSEARSGEPLVDGSSLHDGEILGAMGPSAAHNRGGGADVRRGPSNASSSYSAAARSDGSDGAMYNGNGAAYYEQYGQNPYGEQRPHEPGSQAVIRDNPARRNTRIENSAHYPQQSAGIAQNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPQ9</accession>
    <name>A0A367LPQ9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPQ9"/>
    <dbReference type="OrthoDB" id="5383057at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="151" mass="15581" checksum="2F38DFD050C31053" modified="2018-11-07" version="1">MATVQDRKAPSAGTKVEAGQNAPVTREGAGFVASDSLAAESSRNDGGFAENRRNQPDPSQDFGDYTTSPAKTDASGAQSKMSDAGGFDDPRLKDGLAKALESEPGSADDPSRLAEAQMRQAGAARPSVTGNNQSELSTGTAYDPLSRRVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPR4</accession>
    <name>A0A367LPR4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPR4"/>
    <dbReference type="STRING" id="1330021.A0A367LPR4"/>
    <dbReference type="OrthoDB" id="244495at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF118">
        <property type="entry name" value="CYCLIN, HYPOTHETICAL (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="520"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="328"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="348"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="389"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="528"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="643" mass="69519" checksum="D1F9E8CBFFB0ECF6" modified="2018-11-07" version="1">MSVEQAPPPACVLLGDEAASSDRGLKKPPPSDDMSTAYHPAMPAYDGRAIHGYPSSAMAHPSRSRPVVGNSSQNYRCPPQQMHPAASFTAKNQLSDLSARRSNRGPTPSTGAAKQDADASRTSSETLIYHSLQIPRCISPDGGNLSDFAAQMTCLFWFESAENLKRAETIRSRPPNAPIARLPTLAKPYDQFRKWVYNVLSTTQVTQNVIILALLFIYRLKMSTPQIKGRAGSEYRLLTVALMLGNKFLDDNTYTNKTWAEVSCFAVQEIHVMEVEFLSNMRYNLLASKGEWEEWLVKLACFHEYYDRSLKLPASPMRHPSPASIAFGSPGPSPTTTSLPAAPPDMGPYSSAAAAFSPSPSHHPKGYQVGATSPLTTSKPSMNPASRKRSPEEDLADHPPKRQVPSRPAQGVAVHGHRTGSTADAARLPVPQLSIVTNQGRNAFTTANGYPPQMSAGGQQVVSLPPLQPGIRAMTGLYPSAAPTTMAQQPAQPQAPAAAPVPTTPYCMAPMVGHAAMSYGTPTKHHSPSSLGPFGSSPLMDHLGAGSGGVHTPLSTSSPSVYLQQRNSPYKPIRHVNTLLYPPPSASLDQYHLSVPVQPNQMHYQPLGRRHDVRTGVVPEFLVFNRGQQQHQHLGGQHGHYPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQF9</accession>
    <name>A0A367LQF9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mRNA N(6)-methyladenine demethylase</fullName>
            <ecNumber evidence="2">1.14.11.53</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_3293</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an N(6)-methyladenosine in mRNA + 2-oxoglutarate + O2 = an adenosine in mRNA + formaldehyde + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:49520"/>
            <dbReference type="Rhea" id="RHEA-COMP:12414"/>
            <dbReference type="Rhea" id="RHEA-COMP:12417"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74449"/>
            <dbReference type="EC" id="1.14.11.53"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:49521"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the alkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.53" evidence="2"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQF9"/>
    <dbReference type="STRING" id="1330021.A0A367LQF9"/>
    <dbReference type="OrthoDB" id="6614653at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990931">
        <property type="term" value="F:mRNA N6-methyladenosine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.590:FF:000014">
        <property type="entry name" value="Oxidoreductase, 2OG-Fe(II) oxygenase family family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004574">
        <property type="entry name" value="Alkb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16557">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16557:SF2">
        <property type="entry name" value="NUCLEIC ACID DIOXYGENASE ALKBH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="11">
        <location>
            <begin position="219"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604574-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI16658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="341" mass="38133" checksum="3FF82CC2C58E5CE1" modified="2018-11-07" version="1">MANNNGSQLSDLDAHEPPPASLRAAWKQLTRLEPDASPVDDPLSEESGFVRVGAISRESQAQAFAQLQPGLENQASDETPIFHHPLLPGLLAVPSLLPPPVQTVLLDRMLHRDLGDRQHRTNLHLHYDVPYPGAAPTADADDGSRSLFSLPPDTPELFRPKDPTVHKPLSARQVLQRRLHWLTLGGQYDWTNRVYPPEPPPPFPPDIAHFLEALFPDTLAQAAIVNLYSPGDTMMVHRDVSEHVDRGLVSLSLGCDALFLIAPDHPDVPDKSYLLLRLRSGDAIYMTNEARRAWHGVPKVVRGTCPSHLEAWPARHDGLFREWEGWMRNKRVNLNVRQVND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQI6</accession>
    <name>A0A367LQI6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_1928</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQI6"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI16724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="90" mass="10144" checksum="E2FD3617B9C67BAD" modified="2018-11-07" version="1">MVVLKSDRYKPGFSYLIRDTNKLSTNFSPPSSSSTAPQNTSFDSTFPTLFSKHTYFFPTFFLIKKSCLILRKSLLPSSRAAITIPIRLCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQU9</accession>
    <name>A0A367LQU9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ca3427-like PBP 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_2025</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Periplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial solute-binding protein SsuA/TauA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQU9"/>
    <dbReference type="OrthoDB" id="1363at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042597">
        <property type="term" value="C:periplasmic space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd13637">
        <property type="entry name" value="PBP2_Ca3427_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054364">
        <property type="entry name" value="Ca3427-like_PBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30024">
        <property type="entry name" value="ALIPHATIC SULFONATES-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30024:SF47">
        <property type="entry name" value="TAURINE-BINDING PERIPLASMIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22384">
        <property type="entry name" value="PBP2_Ca3427_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Ca3427-like PBP 2" evidence="4">
        <location>
            <begin position="86"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI16789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="299" mass="32653" checksum="E9B7605B1B6083C9" modified="2018-11-07" version="1">MALRIGFVPEHFSAPLHFAQKYYGLDATLIPFPSGTGHMVTAMRAGEIDVGIGLTEGWIAGLGREGVEGDGGYRLVGTYVETPLRWAISTGAQRNDLTSIDSLRGRRIGISRPGSGSQVMGYVLADEQGWLSSSSSSQEAPFSDTVVLDTFERLREAVNSDAADFFMWEHFTSKRFHDSGEIRRIGDMLTPWSSWKIVASTALAPRHGCLDSRLRSVFQKLDQGIDYFNKHPDEAVVYMSSSLGYTEADARAWLGTVGFPARTEGVKPEVVNNCVAILRKAGVLVEGKGMAPEDMVVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQZ0</accession>
    <name>A0A367LQZ0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">IDI-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3037</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQZ0"/>
    <dbReference type="OrthoDB" id="3660930at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016752985" description="IDI-2" evidence="1">
        <location>
            <begin position="20"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="14098" checksum="B1144723DC17E524" modified="2018-11-07" version="1">MKFSTTIFMTILQVAGVLSSPTESTAEAECGPLGVMKVDLTKLPAGVDPNNIRKCAEHPLRHTLNRRDCWFGDQAGCSKGYCYRNCGTGGSGQWCWSANNGGLGSWIACKKNSDCNINMSCGIGGCKSCGCSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LR07</accession>
    <name>A0A367LR07_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">Chitin synthase</fullName>
            <ecNumber evidence="2 12">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L249_1960</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:16638"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Cell membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the chitin synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2 12"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LR07"/>
    <dbReference type="STRING" id="1330021.A0A367LR07"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF9">
        <property type="entry name" value="CHITIN SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10 12" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="588"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="632"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="663"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="711"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="842"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="883"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="14">
        <location>
            <begin position="172"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCI16884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="915" mass="103646" checksum="DF1EF04335643D86" modified="2018-11-07" version="1">MSYNRLDNGYYPDPMDPRGRPYRSPSPGQPLQQGYQLDDSPYGQQRLTPGPPGHHQRLGTPSDQLNIVAAVRLAHPSTQTVESLPYSSSRQQNYGDAVVNPQLIHDEYGGMHQTYPQQDGAYYEPQVHGYEVDDRRPMLQHHTTGSSGYDDPYRDHAPSQQQQAAGALRRWKTVKQVLLYRGNLVLDCPVPPVLLQQNQHGERDEFTHMRYSAATCDPSDFYNENFTLRQKLFSKPRHTELFIVITMYNEDDVLFARTLIGVFKNIEFMCNRPNSKTWGNEAWKKIVVCVVSDGRAKINPRTKAVLSGMGVYQEGIAKQQVNNKDVTAHIYEYTTQTHLQLKNDTVTLVHRRRPVQMIFCLKEKNQKKINSHRWFFQAFGRVLDPNICVLLDAGTRPGGNSIYHLWKAFDLEPMCGGACGEIKAMLGTGGKNLLNPLVATQNFEYKMSNILDKPLESAFGFISVLPGAFSAYRYVALQNDKNGKGPLEKYFLGETLHGGSNAGLFESNMYLAEDRILCFELVTKRNCHWILQYVKSANGETDVPDSVTELVLQRRRWLNGSFFAAIYAIAHFHEFFRSNHSIFRKLGFFIEFVFQTINMIFAWFAIGNFFLVFKILTTSLGSDTLLGRVGEILSVVFTWLYGVILITCFVLSMGNRPAGSGRLYTAMVWFWAGIMIYLLFAAIFIAVKAIIADINDGDGFNIRQLFTNQVFYTLIVSVMSTYGIWLLASLLMFDPWHMITSFVQYMLLSPTYTNVLNVYAFCNTHDVSWGTKGDDTVEKLPSVNTKDGQGKTDLPDEGDLNAQYQREVALFSTKYKAVKTKPTAAQLQEKQLDYYRGVRTGVVLIWMITNFALAALVLSSAGLEKITPGRGSQADEEKARANLYMAIVLWSVAVLSGFKFLGAMWFLIVRLFRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LR61</accession>
    <name>A0A367LR61_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Retroviral polymerase SH3-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2982</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LR61"/>
    <dbReference type="OrthoDB" id="4960422at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retroviral polymerase SH3-like" evidence="1">
        <location>
            <begin position="18"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="93" mass="10738" checksum="05D592DC20FDE8B4" modified="2018-11-07" version="1">MLYILLPSIAEPNALASAKIAPRAKKGYLVGIEGLYRHIYKVFLLDKDKIVRACDVRFYNPANLNLDRSITHIVNVSKDNNPFNPNNFFYYYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRE4</accession>
    <name>A0A367LRE4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7587 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRE4"/>
    <dbReference type="OrthoDB" id="3783227at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056009">
        <property type="entry name" value="DUF7587"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24494">
        <property type="entry name" value="DUF7587"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7587" evidence="1">
        <location>
            <begin position="155"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="395" mass="43121" checksum="67825F4C78A7B5E8" modified="2018-11-07" version="1">MDQATSDIVRRLKEISLELKDPAELPRETLSQVVDRLADCISAFTREVVKASVAMAVANSKAPEAAGRGTAWGQRAALGKSPSAVRTATKVATPSVVSARSASMGGFAADDGATNADAPQAGNPSLGPTDKLNFTRCYSDSSAGRLCSGKGPVGPSLSSEELVSEFANHRLKGNTTCPTALVSVSDRILDTLKRALNKHYEDGEDPGLIKIVFIEIPSDRAEEVAVHSAQRLAEQCQVEKAWLFKHEYLFEWAIPPEYVRHTVSVETLFHRGLDLGDFRCTNIDGVGTRRSSQCILPPVSVLRQAMAAKYIFNGSDSWEVGVCLGSLARPFGARAPLSWIPRRLYLDLVEGAKGDGDEDFFCYYDAEYFKFMDDGIDDVLVEWWLLSDRFVGDEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRG2</accession>
    <name>A0A367LRG2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_1823</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRG2"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI17035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="128" mass="13441" checksum="F668CA688044837E" modified="2018-11-07" version="1">MTHLLLPYGVVPSLTGSVTVKSIVQSASGLFPRSSILRAVSPIVKSEPTYRVTCLDIPTLGLGSRLSWGAGPGPAQLFSPGSGRPLHITIRDIITTTIPSSSGLWDPGHPLPIMALMLPADDMSLKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRH5</accession>
    <name>A0A367LRH5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_2705</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRH5"/>
    <dbReference type="STRING" id="1330021.A0A367LRH5"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF10">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="243"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="325"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="149"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="325"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="343"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI16832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="802" mass="89131" checksum="2AFB77D6B2860DBB" modified="2018-11-07" version="1">MNVSDLLNRHEKLVHLNEGGNKESDRQKKKSSSSHTSSQSAGSSAARPQTLPFAVPDQPPLQPLDPHHLQQQYHHHLYPFQHSPQNQTLYHHGPAGPGPLPIAQDVHDSPKSGAANLELLSDAALGEPAATINMKPRDEESPPFCPSQEDYNASTPLRESLGTASQIASSQFREDRRTAIWSGLSDSLPSSLSFGSLDPDVHDPGGGQHRVSALEYVSIKNRIDEYSAVLPSDFIFPSRHTLTRFFDGYVFGFHEQLPMLHLPTLALVELSPELLLAILALGAQCRFESNRGYALWYAAKAVVLEQIRRRQSSDVHALLPTAAAYSPHSTRPSPSTTYRHSFASAQSERPMTQDTHREPYSPNTPQARLETIQAALLLFAVGLWGAKTITCDALSLQGTLNMLIRDEGLTDKTNPALLTDWDVWVRLEGANRTRLVAYCLFTLCTVTYDSSPQLLATELNIHLPLRARLWRAGSNWQWQQLRQSTPAAAMTTYEAVVRLFSRYKGKLDRARLSENLSSFGYYVMLHMMLQNIYLMGHLSAPFADLPFETRRRLQPDDADAMMETLQFWRWSFDHRRQLRTAETGYPANAEMAGGPLAHNMAAMVRLAYLRIQADVAPGWTLQTRDSKFVATVLSSNRSSPPRGPRLIRAVNHAVHALSTLVNAGVGYVARAKSEWGMLSSLCNFECAVLLAKWLLALSERKQSDPPVFHEEKKMLELVRVMLDETEFAVPIDPSLLETATSDGDKLRQLASAVLRVWAVMFKATDTFDLIRIFGASLDGYADAVDSRTEAAGRGEGQDGAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRX7</accession>
    <name>A0A367LRX7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytokinesis regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRX7"/>
    <dbReference type="STRING" id="1330021.A0A367LRX7"/>
    <dbReference type="OrthoDB" id="19159at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990334">
        <property type="term" value="C:Bfa1-Bub2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031578">
        <property type="term" value="P:mitotic spindle orientation checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034586">
        <property type="entry name" value="Bfa1/Byr4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35140">
        <property type="entry name" value="MITOTIC CHECK POINT PROTEIN BFA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35140:SF1">
        <property type="entry name" value="MITOTIC CHECK POINT PROTEIN BFA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="689"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="729"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="765"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI17110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="983" mass="109568" checksum="054F519557EB1843" modified="2018-11-07" version="1">MDRQGSKLKTLMDDVENWDDDDLLVDGDELSFRNSLANHGIPPRRDSASSHVSLRSDLESWPGEEKQVHLPAEDESCTVEAIATAEKAGIPLPKDIPYSALMGGTIKRLGGRRIGKLIQEDWDSDLELPDISQTLKLKPKNDSDFPDSLRQVSGESFQAHPKTNFTRDEDERRSAARTSTPLTPVYNLDDSKHDLGTDTIKVSKHRPSQPLPFITPPTPRKQHSSTTAKEVDEDFEQDLELPSDGKFKLSTKRDIPRTPLAQPEELDWGEGSLGTRYGGTRRDGRSNRSSSVSALSPSVSSSLTVESEDETLEGLVLPPGPVNFKERLKKRRKSSSSDRIPEEPEPPSHRKLPMPVEPDRQDFFDGLDICDGKVFDTGKLTLHRNIQVKATRPASPTRIKTAVSLTFTNKTPAQTRIPRLSHERAHSTSLEPVYESGGAAPQRSRRSRSRLGHASQLSVTSLPTPTTTTSPGRSLPPSTPQRREIGTRSSFSSLRVEPSTTSAQLLKQKRSLPAVRQVNNTPAKAMLNRSDRPPSRSGSNRPQSGSGPKTPADRQRPGIVETLLSQARRSHLPFLPAGASQSQSQHVTSKTLRSFRRHDSDNAIDTRPFSRTFSRCTARSPSPRRWRVAADTWERLSKPKIKKQFGDGHELDGFDDLPTSRETETKFLRQPVANTPKTSLRSKIYHHILPERMTTPAPATSNSPARATPTPRFARDTAASRIARETGLALRAPSSGSHASVSSHKETPQTATRSLLPPLPQTTMRAKKTTKRPRQLKPHLIANLNSGKESKVVNGMYYNADTYRWEGNENALNVFDNGPASTPSTTSAAQAWARDKEVTTPRPALITNISATKGVQVVGGMVFDPQNMCWLKIGLPSKDSKSEASDTMDGFNALDDEEDVFKDIPDLEDNTTDDREGRLSEIKDDWLVGEEFDVGPEFIRRQREEEERWRKKCDKWIGRGLRDHDTWRWTIRDLVSQFDDLPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRZ5</accession>
    <name>A0A367LRZ5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_2160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRZ5"/>
    <dbReference type="STRING" id="1330021.A0A367LRZ5"/>
    <dbReference type="OrthoDB" id="5379420at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI17188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="308" mass="34261" checksum="4F14702B063B4A12" modified="2018-11-07" version="1">MAGRYPLTAYRLASKLKAPTIACQSSPLSSQTDRPTLTLGAVTPTLFEKVIASTGNSFNRLTPQQYYARAEKFVELTEQASSVVLVRDSALPPEVVHELGCILCYLSQYTRLSKALWLNASHMGFDPSTISLAMGIVRAECFGELKGFHEVEARFKQLVVEGKNPDALTVEGQRLFMQSDYFGALEVLNRAMRIAGVSDFELKTTCRLHIAKAFLSLDKKTVAMSVFNDVAKTGLAEAHAELGRLLRPTDPVRARQHLYEGAPGRSELYRDLSEMAVEDAASTKGTHHKNLSRWAWEWSRLADRSVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LS09</accession>
    <name>A0A367LS09_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LS09"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI17234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="171" mass="19103" checksum="D75EF46CED6E54F2" modified="2018-11-07" version="1">MARSVGCGASHRWSGVELRGERPVLWRAEKVESPTEICLEVVLLCMYSNFFHSNKKKTDEKRKGKEKRGGVGKGMDRHGWAHISGVLAKLGFVVTKAQVPLYDARIRDKHISNPTHLQRRVNPGGQSRCGAVRIPIRISAHVPAVSREKSWGRAEQAACSEETTRPWPLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LS22</accession>
    <name>A0A367LS22_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LS22"/>
    <dbReference type="STRING" id="1330021.A0A367LS22"/>
    <dbReference type="OrthoDB" id="5329403at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI17243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="718" mass="76779" checksum="939358802DB7AC52" modified="2018-11-07" version="1">MAPSNGVARPRSKQPVKPVVPLPYVKRHASAGSTAPSPPTAASLDQGIGLVSGGGTNNGNDLSPADDAASELPSPKPVDLSESPPVVLDGPRREAADVGLAKAPEGAFSPSPTLFHQTLPPFAPSSRPMPAMVNGEWPYGPAPYPHNGPDPMHHYARPSNGSIHFGTLHDSQGSSPAPPHSAGIAPPPGIGGLDGRPAYMVPTPNGFPPMLSYGGDMVPAANIDNCCHAAANFGPMDSFPPYGANYGPSTPHSFHGSQSSGHPDDVGMYGHFPPGPHRNGGPVLGDDMHHSNVQRRILGPVDHPRMLHGMPPPPPMPPGDLADGLIGYLQQQFASSEFADCTLELRYTDQRAPPLRIPGHRLVLRRSHELASRLQKSALKAGPATVVLESGGRWMRSDAFYMAVQRLYGQPLLPIPPHGRADSGDVMDAGSAKDQLDFCLSYAAAGRLLGWAPVTRRGCEVAMPLLGWQTLETVMEFILDGFVDMGTHESFKYGDGSQMLLDAVVAFIAHNLLPSFRLDTVIENGQRYGRLPVRLPAPAPAIASVEASSLSMARGPPVQLGMGRRPQHIPHIQFGDLSVSEPETPKTTQTLQPASHAMLSRVLLELPYSRIKMLLESPLGLTNFNRWADSARTLKTVVEEREARRRRTVEAVVDGRIAVSDAVRTALRSPSPQDAGQWSLLGWQEEMLPSASPEGSSLLRKWVPLVEEAQNGSTSEYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LS33</accession>
    <name>A0A367LS33_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_3170</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LS33"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="428"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="59"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="573"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI17221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="594" mass="65121" checksum="6B4A38167A457590" modified="2018-11-07" version="1">MASFGKPGAAISSARLKGSEGRDMMDLSGLQHLPVYEQKCTLVSRELDHQGMGRYQWYIWFLCGFGYFLDLLWAQAFALVLSPLQQELGFSNSQSGNISMSFNVGLTTGAFFWGFMSDIVGRRWAFNLTCLLSSVFGLCLGAANNYTTFLVLTAFIGFGVGGNIPVDGAIFLEFAPQYMLACLSIFQPLGVIACSALAFAFIPTHSCSPNFSEPKPLPSCYNVSGTACCSRETNMGWRYLLFTLGALTLGIFVLRTLFFRCRETPRFLIYRGEDAKAIRTLEYVAKINKRKCLISLQLLDSLQNEYDLKQARSSQFSPPSPLSPLTPLSPVEERRRLFPKTKMQKMGRELARVKLLFGSLRMTALTVLTWLTYILDFGGFNIAGIESTNAFAFVTSCSLCKQTGFYLPRILALKNGQESISLNHTYASYIYCYAPGILAVLLGAYASQIPAFGQKWTMVASSALMGTSIFLLSRVDSAAKSEGLFALEYFFQSTFNAVLYGWTPQAFPAPIRGTACGVASFWGRLFGIVSPLIAQNLYGRASGSRGDVDGVLYLAGGVTMGCVVTTALLPRSPAEEEAEEATDSSYEPIASPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LS85</accession>
    <name>A0A367LS85_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_3151</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LS85"/>
    <dbReference type="STRING" id="1330021.A0A367LS85"/>
    <dbReference type="OrthoDB" id="408493at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF562">
        <property type="entry name" value="ALDEHYDE REDUCTASE II (AFU_ORTHOLOGUE AFUA_1G11360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="283"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="9">
        <location>
            <begin position="824"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="129"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI17269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1228" mass="137452" checksum="E0580A38DE09FC70" modified="2018-11-07" version="1" fragment="single">RITEEEAFYFVGSPSISNQGSLFQVGESLFVRILSDLNPTAAAVYDVLAPKEATNKSIAHISTSYQAVAAATGLVAIQVGLGVILKLAQNDGSYSFSTSGSVSISEFGKLILSTILFCRECSHRIARGMKPRTHTGGDYESPPLTSTPGASSRGQNGRDEDDEEEYFPHVKLQYNMVDAKLSPAVVWRYFRGEVTDEKQAGFYILALCYTLINNSIFLSYYLADPGTIQLSKSSGALMTAVIMVVSLKTALSRIQWATIFLQVFGLILSQYKPGIGSAYPATTYAILFFQVFISASSAVYNQRLLKTDNNSMHADNMILYAFGTVINLVCHLFIFTMAADEPSFFVGYSDIRAILVVVSHAFVGVAITYVYKCRFHTQLPWLTVLTERQDADAVVKCLATAVATGILLFLSPILFGSELGSLVIPGTLIVFASSWLYMMYPASTSQTADHDSKRLPKYWRVILGLLTVVTVGIVIAMAVVRDRLPTTSKQSSQHAVHESKDDEVVSPFHDVLAMVRWNSAHPERVPQIIKYEPFFDTVHISMPGMMPDQPETFYNWTHDQFRGTFTIYLQVAKTMQMALAEKPHIKGLMYFHFDAWLDPLAWGDTNWDNIWIANGSTPPHQCITSTRAYDWWGWASDLHLKLMNASAAVQQLGLGYKVNTKEWCLGWSDIYYIPRRFFADYILLADVYNQFDAFHELAIPTMLNIINNSQQSNTSVVKLVEDCWGSCCDTIAKPDQVLKNRCGHRLDYLNQPAVDQYYAKLDAQAKLTGLMETNFKYQTWASSSISMSTSTERILPFHYLYHEAQVCLNYSIRTMQAVPTGSLILVTGVNGYIASHVAEQLLEHGFRVRGTVRDVGKANYMHALFDQKYGFETLVVEDMAMRGAFDEAVKGCAGVMHLATDLTLNPDPNKVIPMVLSGVRNALTAAAAETSVKRFVFTSSSAAVTPYTRNKRSYVDSTSWNEREIEDAWAPPPYNDDRKLAVYAASKALAEKECWRFVQEEKPAFVLNTVLPNCTIGRILSKEQPASTGGWYRKFWERDESILGLMKNLSPQHYVNATDTALLHVAALREEDVVGERLLAFAGPFNFNLTMEAFERLRDQGYGNDKREFPRIADDDRDLKIVDTTRSQELLKRYNRPAFADLDMCLKEVIESSEGFQKESSAYRIYESFTTVGEHDLMIVETASDAGKEQDRCGNVRLRTGSTYQASSATAWGYVRHRAIHGGFLIRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LS97</accession>
    <name>A0A367LS97_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ras-related protein Rab7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_1998</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LS97"/>
    <dbReference type="STRING" id="1330021.A0A367LS97"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032889">
        <property type="term" value="P:regulation of vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01862">
        <property type="entry name" value="Rab7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000086">
        <property type="entry name" value="Ras-related small GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF20">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB-7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI17326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="23039" checksum="0D80D262C6BEF5AA" modified="2018-11-07" version="1">MASRKKVLLKVIILGDSGVGKTSLMNQYVNKKFSASYKATIGADFLTREVLVDDRQVTMQLWDTAGQERFQSLGVAFYRGADCCVLVYDVNNSKSFEALESWRDEFLIQASPRDALNFPFVVLGNKIDVEDSKRVISRKRATTFCQSKGDMPYFETSAKEALNIDQAFEVIARNALAQEESEEFSAEYDDPINIHIDNDQDGCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KYZ9</accession>
    <name>A0A367KYZ9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_1383</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000031">
        <property type="protein sequence ID" value="RCI07401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KYZ9"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI07401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="148" mass="16435" checksum="E28C6C9FCD3E86F1" modified="2018-11-07" version="1" fragment="single">PEEKKKKKDPEEKKKKTTNTRTKVRSYAAVVPVVTAIVTAVVTAALGSYPYSAVDLVPDPDPDPDPDPDPDPVPVVARRENDTLGWNRTLIYRKFDCLDRPPFLGSLTYPTFLPSYGPYGPYGRSRSAVTYSLCNVRRPRAGRSRPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZR2</accession>
    <name>A0A367KZR2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_5750</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000024">
        <property type="protein sequence ID" value="RCI07669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZR2"/>
    <dbReference type="STRING" id="1330021.A0A367KZR2"/>
    <dbReference type="OrthoDB" id="10253744at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF189">
        <property type="entry name" value="CYTOCHROME C MITOCHONDRIAL IMPORT FACTOR CYC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0274">FAD</keyword>
    <keyword evidence="4 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="10">
        <location>
            <begin position="45"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="267"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI07669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="373" mass="40702" checksum="C2D8084F9204DF04" modified="2018-11-07" version="1">MSPSPTVASSSPPRLVLAASAAAALAAVLSAAAYHHRSASWRDRDRFVRCLVTDREPVSSSAAILTVAPPMIPCHGRLWTVEFKQPEVQIARHYTPLPPRGPDDNRLRFYLRAVEGGEMSAYLTRLSAGHDLWLRGPHLGFDIARRLGRRKRLVLLAGGTGLAPAMQAAAAVLDKPDTSATLLWAVRRRDEIQLTRPSHPWWRKNLLWLHSPAPNELGPQQLEEPSPIAVQLSQMKARYGSRLQIRIAIDEDGSIFRDEDIQRALLPPSPPPPSLPSSSAFPPPASTNCECHDQALHASASEFDPPNAICRCPPPAAGKNLLIVSGPDGFVSHYAGSKHWSGGTQTQGPLGGVIARLQRRHPSLARDWLVLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L014</accession>
    <name>A0A367L014_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_5668</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000024">
        <property type="protein sequence ID" value="RCI07783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L014"/>
    <dbReference type="STRING" id="1330021.A0A367L014"/>
    <dbReference type="OrthoDB" id="2308815at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052985">
        <property type="entry name" value="CoA-trans_III_biosynth/detox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48229:SF1">
        <property type="entry name" value="ALPHA METHYLACYL-COA RACEMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48229">
        <property type="entry name" value="CAIB/BAIF FAMILY ENZYME (AFU_ORTHOLOGUE AFUA_1G05360)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="541"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI07783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="563" mass="61756" checksum="F1A46AA07E7EB378" modified="2018-11-07" version="1">MASPDASSYSSKAESNRILSLIHDIFDNDSLSLPAEVTAKSRQVRFRAGLGRPYFPIPFKQTETAAALKAIEASVAALLADSGGHVRDRNMVVDLEKTTAFLFQAYLARIGGLGKLDAGVRSLLKDTDYLQAQSNPYRRMAANLYATADEGEFYHIHGSLEASTTLQMLGLAPYRPDLNTHRDIVDVIEPAVRKHTVAELEALNAHHRQAGVKAFKHHDFLQTPHGKAAWDVPPWTVERLEDKTPPRQLPQRGPRLLAGVRVVELCRIIAGPIMGRILAEYGADVLKVTGPGISDVPFFQVDGNMGKHAAELDLKTVEGRAAFDRLLESADVVLDGYRPGVLDRLGYGAGELARRAERRGWGIVYVAENCFGHRGEWAHRPGWQQIADCASGIAWDQGRFMGLDEPVVPPFPISDYGTGCMGAIAALTGLLQRSARGGSWLGTTSLLQYDLLLYKAGPLPDEEQRRLRDEASAEFLSLRHAHSVDAVSGAALRQMRTLYPGLIDSRRHMDRWFSSGYRAEVAVVKPVVEVDGLQLGFSRATRPNGMDEPSWESFGDDGRGMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L051</accession>
    <name>A0A367L051_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61</fullName>
            <ecNumber evidence="2">2.1.1.220</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">tRNA(m1A58)-methyltransferase subunit TRM61</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_5681</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.220" evidence="2"/>
    <dbReference type="EMBL" id="LKCN02000024">
        <property type="protein sequence ID" value="RCI07796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L051"/>
    <dbReference type="STRING" id="1330021.A0A367L051"/>
    <dbReference type="OrthoDB" id="1925287at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160107">
        <property type="term" value="F:tRNA (adenine(58)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049470">
        <property type="entry name" value="TRM61_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133:SF2">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE CATALYTIC SUBUNIT TRMT61A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 C-terminal" evidence="11">
        <location>
            <begin position="124"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="77"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="353"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI07796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="920" mass="104037" checksum="652E649EDA637742" modified="2018-11-07" version="1">MANPSPSPFLEPGTKTRANTLAIVSLSRDNFQPITLEQSSGAVDGYAEGATLNTRFGSFPHSTLLDIPWGSQVRASVVDTGSRGRKRRRDEIESDATPVASPDEADDGSGPTMVPAKAVAAASGFIYVLRPSPELWTSSLPHRTQVVYTPDYSYILQRIRTRPGSRLIEAGAGSGSFTHASARCVYDEDARGQVFSFELHEPRFRKMQEEIRDHKLEGIVRITHRDVYRDGFLIEGRSPKATAVFLDLPAPWEALHHLSRRKEDDNWICPLDPEQSAYICTFSPCIEQVTRTVAELRTLGWTDIDMVEIVHKRLNVMRDRVGVNVPGEKGFNPTSADVDEAVVKLKEDLKRTQEFHKAQHSNDGPPVKSSTREATNGKEKPAFMQGGIVHRAEAELKTHTSYLVFAILPREWGAENEAAALAKWPCGQEGKTIGKLDKKARKEEKRQMLASKKKKRKAVQAGGLLRLGSPATQQMAIFDELADLQRDRVSKQWIYLAFNSQKEIADFVAQERSGGKAEGIVSWFAGSYNFCFRVRFDDGGPDAVIRFPKPGCTTFCEEKITNEARVIEFILENTTIPVPRLISWGLTKDSPKQLGPFLISDFIDGVSLSSLLRDETDSDRQSLSPNLDEQILDTIYEQIADIVLQLFQFDFHQIGAISKDMSSNTWSVSGRPLTYRMNELATTTFFPINKFPTKPFASTKDYFQSLALENIINLQTQRNIATSQDRARELYVARHQFVRLVDKYYIDNEGPFKLFCDDFRPHNILINPETLRITAVIDLEFTNAMPSQFALDPPWWLLLAEPETHLILGHTPAEFSTAFEVRLNQFLQAVQRAEKARGLDYASYTISSRMRDAWNTKRFWFNYAARNPFDVEAVCANFLKEESNSCDELLDEQVRSEMESFVQMKMEQLKAYDRECELCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0J1</accession>
    <name>A0A367L0J1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA repair protein RAD51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_5848</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required both for recombination and for the repair of DNA damage caused by X-rays.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the RecA family. RAD51 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000023">
        <property type="protein sequence ID" value="RCI07934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0J1"/>
    <dbReference type="STRING" id="1330021.A0A367L0J1"/>
    <dbReference type="OrthoDB" id="10251254at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990426">
        <property type="term" value="P:mitotic recombination-dependent replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19513">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000008">
        <property type="entry name" value="DNA repair protein RAD51 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000092">
        <property type="entry name" value="DNA repair protein Rad51 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011941">
        <property type="entry name" value="DNA_recomb/repair_Rad51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003301">
        <property type="entry name" value="PRK04301.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02239">
        <property type="entry name" value="recomb_RAD51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF39">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="Rad51 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="9">
        <location>
            <begin position="100"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="RecA family profile 2" evidence="10">
        <location>
            <begin position="280"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI07934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="349" mass="37732" checksum="5EA810A490F8339C" modified="2018-11-07" version="1">MSGEDHDENQMEDENGSTGPGAPTPLSALEGVAGLTKRDIQLVVDSGYNTVESVAYTPRRMLEQIKGISEQKATKILGEASKLVPMGFTTATEMHQRRSELISITTGSKNLDTLLAGGIETGSVTELFGEFRTGKSQICHTLAVTCQLPFDMGGGEGKCLYIDTEGTFRPVRLLAVANRFGLSGEEVLDNVAYARAYNSDHQLQLLNQAAAMMCETRFSLLVVDSATALYRTDFCGRGELSNRQTHLAKFMRTLQRLADEFGIAVVITNQVVAQVDGGPSAMFNPDPKKPIGGNIMAHASTTRISLKKGRGETRVAKIYDSPCLPESDTLFAINEDGIGDPSPKDMEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0M1</accession>
    <name>A0A367L0M1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWR1-complex protein 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_7814</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000022">
        <property type="protein sequence ID" value="RCI07979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0M1"/>
    <dbReference type="STRING" id="1330021.A0A367L0M1"/>
    <dbReference type="OrthoDB" id="5338195at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140849">
        <property type="term" value="F:ATP-dependent H2AZ histone chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037651">
        <property type="entry name" value="Swc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057558">
        <property type="entry name" value="Swc3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28108">
        <property type="entry name" value="SWR1-COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28108:SF1">
        <property type="entry name" value="SWR1-COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24707">
        <property type="entry name" value="Swc3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SWR1-complex protein 3" evidence="2">
        <location>
            <begin position="54"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="638"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="294"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="642"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI07979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="706" mass="76096" checksum="05CA44BBF31C4BAA" modified="2018-11-07" version="1">MEKKRKLTRASARAEQATKKRRDRSPSPPPPPPQPQSQPQPELSSSIQVGKPLPTVEEVQPDLPLADYQSISESGVLAESLCRSRQRWTSDGLFEKFWSKPHKRKGVLQEDPGNPPKDSMTRVGTVTLAIEPHIIEATMFVVKAPKPPEPVQQQPSTPARQDNPASSSTLARPVLQYGPPSGVMPPPSTPIFVPIALDRPSVAPPSPATNASQRSVSPSSHNKSGVVSSVEPCELPSPATVAANATPAAASAGPATVHTNTSPATPIAAAPHTVASQRSCNGPQQTAAPPAVGAQQTSPAPTATSQATDRPTAASAPAAPKPAANDPVIALLAQKASGDSELRDLMKRVAVGQAKDGELAQFQKVIDQLNAECKQRSGPPADKLFVDGRTVKYFADEVRTILDIVLASNPNQKSAELKPPPRSDPLVVLLVKTALEDQRTRDMIRRIADGRPGLTDAQDLREILDRLHRDAKTVPKGPPPRPKHPPVANGAANANSPQATNNAQALRCKGLSSSTARQDISAAVFDFGNGDRYLFPKYSILEYLPTQSGQQVIASFLIVRKGSSSEYGGDPALDYYQPVTIRISTASGRYLDNLARVVASPDEVRRYMDDVMDNMTRAEYVLLAMRLPRVDVDIQGVFTPADEPKSDPELDRSQPTKPGVLWATAASKKPLELSEPIKFRDAEQQTQLRYERFIRSMAERDPEPVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0Z9</accession>
    <name>A0A367L0Z9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_6353</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0Z9"/>
    <dbReference type="STRING" id="1330021.A0A367L0Z9"/>
    <dbReference type="OrthoDB" id="1694274at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02603">
        <property type="entry name" value="HAD_sEH-N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052898">
        <property type="entry name" value="ACAD10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829:SF1">
        <property type="entry name" value="HAD FAMILY PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI08110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="283" mass="31709" checksum="1444D1C892988BDB" modified="2018-11-07" version="1">MSRPKQPKVLLFDIGGVCVISPFQAILDYELTLGIPPGWVNYSISKASPNGFWHRLERGEIPLDAAFFDGFNRDLHDPALWKKFYEREQLKNDNLAQTLLPPLPALDGEWLFNKMMHTSQEPDPWMSPALKSLRESDSYILGALSNTMIFPPGHALYHADYFKHPLRQSFDVFISSAHVGLRKPDPAVYKLAVATLDQYAKDNAASERGSRCGWQVGVRADDILFLDDIGENLKVAAAQGFRTIKVPLGKSYEAVEELEHVTGLKLQGHHPKSHSSTTTKAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L144</accession>
    <name>A0A367L144_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L144"/>
    <dbReference type="OrthoDB" id="21418at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029196">
        <property type="entry name" value="HAPSTR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38645">
        <property type="entry name" value="CHROMOSOME 9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38645:SF1">
        <property type="entry name" value="YALI0F12243P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15251">
        <property type="entry name" value="TAPR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="320" mass="35228" checksum="0F32F6BC4E198D71" modified="2018-11-07" version="1">MLGTPTDGTRQIAGGIMALLRLGMFSPHVTRQTSQQTNLSASNRFCSRTQNARLDQPRFTTIDSADVAASRKAPFTHQQTPKGMDPARGSKRNMPLHESPEQLLDVFKAAALSVTKLYKTSALVESRARTEGYQECLQDLLMLLDRENLGLRDGEGWTIRAWATERLDVRDPTLLQATESEDEVERSDRTTSPELPRTSTEPQPPAQRPAEPPTTSVVSVHEEPAPIVVPTQDAFTFQSTYPYPNIATLDLSDSRHDVPPLQAPRNSKTRMSGSKPGSRTSGHLGRGAGNKRRWDINDFFGGCLSGKDPLGNGSKRSRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L167</accession>
    <name>A0A367L167_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_6241</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L167"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI08180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="94" mass="11266" checksum="F84F09554EC96F23" modified="2018-11-07" version="1" fragment="single">TRCKDIRTFSRKKGEFSAFLTNLKNKIRTDKATFRDEENRIGFLFRSLEGKARKTLETYLLTKTKDDSLSYEDFYGYIKDSVYCRKRDAIRRET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1A0</accession>
    <name>A0A367L1A0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_6281</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1A0"/>
    <dbReference type="STRING" id="1330021.A0A367L1A0"/>
    <dbReference type="OrthoDB" id="427030at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002157">
        <property type="entry name" value="Transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000417">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050717">
        <property type="entry name" value="C2H2-ZF_Transcription_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196">
        <property type="entry name" value="ODD-SKIPPED - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14196:SF12">
        <property type="entry name" value="ZINC FINGER PROTEIN 208-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016743653" description="C2H2-type domain-containing protein" evidence="7">
        <location>
            <begin position="21"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="265"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="295"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="325"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="353"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="80"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="220"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="416"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="164"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="416"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="441"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="481"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="494"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="548"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI08194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="595" mass="67021" checksum="A05BCF225F28DF63" modified="2018-11-07" version="1" fragment="single">GKRNIIFLLVSLPVARLTTTDKLALTASPVATQTWGRWPQQQASHDFPGMMEAPGFISYDSRNAHLQQRPLPQQYVVGPTYNAASLPNSGPPPQQHPYSSQSPFPYVPYQSSPPSTPIGSPFKHDAHQRPAHGQRMPVPVDDGPRHGPFRRGSKSLSESRRRQSPSTRSESQVSTTARSIMSNPTANSKTITYNETINPADRINFETDVDELMKVIQTNDDDADEEVAPRGQAPTPAHTPVSDAASVQKSPAPPGRAESKSKKKWVCDGPSCRKRFVQKTHLDIHRRTHTGLKPYVCTKDNCGLTFSQRGNLKTHMRRHTGEKPFSCGICGKMFAQRGNVRSHEETHKGLKPFVCRLDDCHKTFSQLGNMKTHQNNFHKESLQQLTSMFIRCAQMGQVPDEHQELFEYFKAHYKNSNKGIKGRGKARTVAPKVPKGESQAQQQQHQQQQQHQQQQHQQQPTQQHHQQQYSQSQQQQSQPPPHHHHHHHHHHQPQHQSQPQQQHTPPQQHPPPPPTALAFPHHLPMPNPQQPSHASYVPGPAGPMTSIPRHHHHHHHHASVFDAPHQPPAAGNGAAGMLYEDEHARQMGFTTDRMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1D4</accession>
    <name>A0A367L1D4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rho termination factor N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_6324</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1D4"/>
    <dbReference type="STRING" id="1330021.A0A367L1D4"/>
    <dbReference type="OrthoDB" id="4034134at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038872">
        <property type="entry name" value="Put_GTT3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41807">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41807:SF1">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="326"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI08226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="354" mass="37943" checksum="DF5C931F884870E3" modified="2018-11-07" version="1">MMASTNSWLKAQRKSELVELADSVGMTEYDRLKKSELEIALDEFIPRHASSLASRSDLAGYFASRSKALASSPVKRERVDEPLLRVPRSRITRRASAAPPPPPPPPAAAMMIHELSPESPSESGSSSSRSGSLVLATTQTPLRNVELASSVMALPATPADIAQAVDRSTTAVRRRFSTLYRDSGIPLASVTARQALSTVNSILLFVSLVELCTIRPEILPSRQAFVVPAMPALGTDDYPVPLPDMFLLLSSSFWSPAATWALTAFVMPCLAGYVFNLTAAARAAPNVVVDPLVFSIAKALVAKVVYGHRSTLHGLLDPVSIERLDGAVYGGYRGVIVGAVITGLVSMYDAVLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1P7</accession>
    <name>A0A367L1P7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1P7"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="146" mass="16827" checksum="CB1F43EFD2D88BB8" modified="2018-11-07" version="1" fragment="single">MKLEKGNLPEEKADEKQKKKKKKKTPIIKVHHRGGPERRRKRGNPRQRWMTTTTKQEDIKFDQGLGQFTVGCFSLGSPARGGSGRYGGLFLNLSPFIGKKKNKKRFKNVCLVALWSCPLGLIRLRMQSDWKNIKEDRERHPSKPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L259</accession>
    <name>A0A367L259_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_8781</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L259"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI08487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="172" mass="17845" checksum="B3F9D4CE9AF4A4A4" modified="2018-11-07" version="1">MLRTTPSLARRSPILSPWLFELTGKTNRRSDAVSDVKSSLNRPDTSTLPRNPWPSLTALRLRVARPQGRFVSVAGAASGSAFLFLVVGVIVVALVAAVFVIAVIVTPSPPRASSAATRPSRAAILPVKPPPPSLSSPLPSKTTATAALTASPLTTANAAFNAASARRLSSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L264</accession>
    <name>A0A367L264_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_8840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L264"/>
    <dbReference type="STRING" id="1330021.A0A367L264"/>
    <dbReference type="OrthoDB" id="2507140at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016892238" description="Extracellular membrane protein CFEM domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI08521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="163" mass="16409" checksum="8D3B59A2050D9574" modified="2018-11-07" version="1">MKLLLPLTLLATVAGVSAQEKCDADYIVEACLSSERAKVEVCSPTDYDCLCAAHGAVATCYNNCPNDQRASSARQAVRSNCQNASMYGSKAHASKTSSMSPSSTSDTSATPSDSASTTEGVQRAASSTSTSTARPSSSGAAEALSGNTGGLFVAVAGALVALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2D1</accession>
    <name>A0A367L2D1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_4756</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2D1"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI08575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="491" mass="53867" checksum="BB7D3532CC9CDDEF" modified="2018-11-07" version="1">MTTSVSVSVQRGRIGAIALIQTCPFQQFLQGCIGDMSEHALGQPPRAKAYPRLGAGEREEEGHAMRWGHPVKEYQTHPGLGVAGLAGLIGMRRANERSADYRTRKKKSNLLSGSTYFVFTTLFPLSPSLTIVIISALGDSLPLFFSFLSLSPLLLASFPLSTQLNPPSRQVQGSTPRHEGARCQDVVSTPPSPPLFSPSPSSPERAGLLRTRTATGCDNPLFGSLRVQQKKTTFKEYLRKTDDSCGRQRFHLAFPRPHLFSPKFLLTLRLKGGSQAGGRIRQEQQAGCSSTPRGVYAGADLGCPSRADKSIMTAAKIKKEQDKEMNNVSPLSLHPFFPTPSNDMLLYLDLLSGHSLRDRQAAERERGTNHTRLLPPSLRPQCRRKPDRDKSQRVGRLFHQIGQECARSGRLQAFRISSPAVCDAAAQGFGPGLKDAPGQAIAARRLAMPPKIKKKKRRAASREPRTANPGCVLARWLAPVFRFPIGQLLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L310</accession>
    <name>A0A367L310_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PQ loop repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_4843</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L310"/>
    <dbReference type="STRING" id="1330021.A0A367L310"/>
    <dbReference type="OrthoDB" id="292213at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052241">
        <property type="entry name" value="SLC66/Scramblase_ANY1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14856:SF9">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14856">
        <property type="entry name" value="PQ-LOOP REPEAT-CONTAINING PROTEIN 1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI08821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="289" mass="31954" checksum="1D49E3A08D045318" modified="2018-11-07" version="1">MSGWLAACAGYVAPLFIVLSPILSYGDQALSMHRAKSSAGFSLDIPLIMLVASFFRIFYWHGARFDTSLLIQSLVMVAMQLVLLKIALDHRPGPSSKGDEAAIPFVGAQHDNLLSVQRPFSFWQWRSPKPYWQFLVYLVCVLMAFEIVLAAMPPVYALWSATLGYVGLSVEATLAIPQILANSQARSCKGFRLSVLVAWLGGDALKILWFFTSTTDIPVAFKVCGIFQAACDCLLGAQYMQYGEGERYIAEHPLEEGQWSSAVMTSDRPHSRSFSQTKSGVIYTDTEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L319</accession>
    <name>A0A367L319_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_4841</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L319"/>
    <dbReference type="STRING" id="1330021.A0A367L319"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI08823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="518" mass="59371" checksum="C11700D07CF4D35E" modified="2018-11-07" version="1">MQTVAGVLATGVAYYVYQRVRDSPDGEKESCKPPLCDYVDPIGVSGLYRSLRASNENRFLDFVQEEIDSVGRRVGRPLRTVSVRVLFFQNAIFTFDPLNVQAILGLRFDDFELGTSRIEGFRPYLGTGIFAAVGKQWELSRNLLRPHLFRSRIDLEQGERHVQAFITALDRRREPSRWTKLTDLQDLFFHYTLDSTIEFLFGRNVNSQLGEETQDVSFSKAIHQSQSGISLSAKLGPFYWLAHTPEFKRHLKTINQVVDPWIDAAIKQRQTEEEVEQENCPLLYALTKQTEDPIELRNQLLSLLVAGHDTTASTLAWFVILMADRRNEAIFQRLRASILDHFGDGSDPKEVTFGRVKSCRYLQWCIDETLRLYPAVPMNIRVAKRDTCLPTGGGPEGLSPILLKRGEEVTFSHLIRRSQRKQVHLMHRCKEIWGEDADVFRPERWENKPSRWNYVPFNDGPRSCIGQQYAMVRIAHLVIRLLQRVDGLDGSQLGSVGQHLTLVNLPDNGVKVRLRFAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L386</accession>
    <name>A0A367L386_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PXA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_5082</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI08884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L386"/>
    <dbReference type="STRING" id="1330021.A0A367L386"/>
    <dbReference type="OrthoDB" id="41200at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000065">
        <property type="entry name" value="PX domain protein (AFU_orthologue AFUA_2G07450)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013937">
        <property type="entry name" value="Sorting_nexin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775:SF47">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 122 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22775">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08628">
        <property type="entry name" value="Nexin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="PXA" evidence="5">
        <location>
            <begin position="151"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="4">
        <location>
            <begin position="471"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="366"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="644"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="376"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="422"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="668"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="702"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="714"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="731"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="791"/>
            <end position="819"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI08884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="987" mass="105850" checksum="F686D187C2FF9331" modified="2018-11-07" version="1">MASPTDGGGNAAAGHARPNAAPDPPSSRHNHARTSRLDRPPTPTQQGVSAKALHFISTASPGTLAGIAVAFSGVTYAILGRLGLLVIGAVGGVIAFASLEAKHPDVARAVRGEKGPDVLDRLWLDLQNTSSSSPAADDDDDLPLKTFDDFRPETREALGGFVDAIIRDYVKWWYSPLVPTDHSFPLACRKVLNSYLISISNRMSRKRPADAFLDLLTNCSSIIIVFMSELAAAYADLPPDTNMTAADAIYNYLASNPDSRLASLLNQRQQAAKFKMVAEDLLVFLERAPQSCDPARVFLREILANSVLETTLQTCSKAEWINGMIVHLLEAGEPDLNQAIDVGMQNGNDAGVPNVFADLDGNVGNIGIAKPGRSSPEAERSRRKDSSGQGNGKTPPRGDSLARGGSVSEIESTPSRWSMAGSSSRESPSPPNNRSSGQQFTSFDQIVSHGSVQALEHDAPKKEPLHLHNASFTLHDDTTGDGGKIRNKPNWDYLIQVEPSLAVYSGWMIVRRYSDFETLHEILRRIATVSGATAFTELHKELPGWKMHTRESLRGELERYLRDACWYASLAESEGMKRFLEKSQGHTHGSSKSFGWETVGKNMLDALTIGPKGAVEGGKNLVGVFGLGRKPTNPLSVVDAAAASTGRLSRSNHSPVAKSPARSERASTDSQRSSVISTQPGKVAPMDRRASHQFAGGEGDVDYTRLGRLDRTDSGSAGSNSAHPSREHSRASSLAPVQSPSMSSLDMMKLPPPPDEIDDDYMALTGTGGAGDGYGSPAAQRDRRRSSVNVAATASAKKTAAAGMPSSSSSSPPSAARPARQYSQLSEHETRVAVELLFAVINEMYTLSSAWNIRRTLLTAAKSFLLRPGNPSLLTVQSLIQTTVLDANTSDGGIAATIRKMRENSVPTEEEKAAWPADLSADEKEKLAVKARRMLVQRGVPAALMGVMGQAATGEALGRVFDCLQIEEVARGLIFGLMLQVVRIVTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3R1</accession>
    <name>A0A367L3R1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_4972</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI09061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3R1"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI09061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="98" mass="10552" checksum="B7F99A64B605EFE2" modified="2018-11-07" version="1" fragment="single">GTGWVGIKGVNSSYRVRRGSSWTARINWSRQSWSSSWGSDEFGIEAFNGLLGELATNEETGICSEVVGSGVGVLLKPEIRARTCRYPSLPSDGISLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4X2</accession>
    <name>A0A367L4X2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_3656</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000015">
        <property type="protein sequence ID" value="RCI09469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4X2"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI09469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="94" mass="10418" checksum="54318DBF49D7C705" modified="2018-11-07" version="1" fragment="single">KDQHDPPDDETARANFFKERSERTLCLNRKIHAPRNGMKPVYPCGQNYHSNRTRSGLLDSGGILNKDVRAVSTAIARFTLGESHASQAPANLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4Y0</accession>
    <name>A0A367L4Y0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_3659</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasm</location>
            <location evidence="1 6">Cytoskeleton</location>
            <location evidence="1 6">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000015">
        <property type="protein sequence ID" value="RCI09467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4Y0"/>
    <dbReference type="STRING" id="1330021.A0A367L4Y0"/>
    <dbReference type="OrthoDB" id="78652at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF27">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4 6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="9">
        <location>
            <begin position="2"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="8">
        <location>
            <begin position="299"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="683"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="691"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI09467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="740" mass="80347" checksum="BE2585BAF9C737F9" modified="2018-11-07" version="1">MLHEMLLALSGHPSPLLRDPGPEADASVGITPPERHLLSSVAHLGHVHSQLVHLASSISSSHPSAICRAVAAAIQTRHLSAFQRKVLDVEQSILSNGPAFVGAYSIVPLTAVVGEFQQWTARMDWLLETAQFISTSKQALTARHGVDLIDRLRRQSQSGYRHVAETALSLLSAAETAWLKQATAWILYGRLPNFGAVDLFVQASGEEMVLVSELLPSFVTPRTASSMLYIGTTLHRIRAVGDASASLGGLDCVLSKLQLLASLASPLSAVEFSRAVGSIRLSLFQQSLSKLLPMAKVVEMLHLLRNFFLLGRGEFALALVQEADDEICGRWQRVADGVGKVAVDESQVAAVLNRTWAVLAAMQGQHGDEDEELDLARDLLRLLPASSAPLGPGPGLSADAAKLLEALPFGNLLLSVPTMLSLKPPSPLDMVISPSDMGLYALINSYLLSLRRAHIRLTDLWKMTSLRRHHTAPVGAGEQAVALRMRWSTRSAALRGSWTTASAAVFFLGETEAYLQAEVVGGMWESLRSWLGGDDEKCEETTWEKQSIIAGSDGEDDADVFLYSKESVTAPEAEARRAHDPQTLARAHSVYLATLARRLLLMEPTFTGSLHTLLRHIDGLASLMRRLHAIFTATDLETDAGVVDASVDLGREEAELTAQLGATEVKVRKGIEHVVEQLRALESRPEREAEVGDEDNDEDDDALLPGRKYVVGNIGGVDRLLMKLDFGSWLGSRLDGWETC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L535</accession>
    <name>A0A367L535_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_3944</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L535"/>
    <dbReference type="OrthoDB" id="196650at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000223">
        <property type="entry name" value="Major facilitator superfamily domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF31">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI09518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="417" mass="44853" checksum="2C3BF59C7D1E803F" modified="2018-11-07" version="1">MHISFTFILPLFPRLLEFYRDREAPSLREAGPPTLLQRLLVGLNSYKAAFSRPIDSRHDIVLLGGALGSLFSLLQAIASPVIGRLSDRRGRRAALLASMCGNILSVLLWLAAVDFRTFVASRVVGGLSEGNVQLANAIASDISDDASRGSTMAIIGACFCVAFTFGPALGAWLSNIAIFSANPFAMAAGFSLFLVLVETIYLYRCLPETLPALTRPERRAQKAEAVVKRQVERTNSPSVLYAVNFFFLLFFSGMESSLSFMTYDLFAFTSAKNGRLLGFIGLVASILQGGVTRRMPPLQSIRVGLLACLASFVLLGRIDTIGGLYAAATCLATTSATVVTGLNALSSFDASEDERGSKLGVLRSWGQLGRGLGPILFTSMYWWAGRAYAYNVGATGILMVAAAAMVGLKTPRTQRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5H4</accession>
    <name>A0A367L5H4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,3-glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_3836</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5H4"/>
    <dbReference type="STRING" id="1330021.A0A367L5H4"/>
    <dbReference type="OrthoDB" id="5589195at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042281">
        <property type="term" value="F:dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413">
        <property type="entry name" value="DOLICHYL GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413:SF1">
        <property type="entry name" value="DOLICHYL PYROPHOSPHATE MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03155">
        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="181"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="235"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="408"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="478"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="510"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="545"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI09686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="591" mass="65846" checksum="B2996DB44957057A" modified="2018-11-07" version="1">MAPASPSPRKPRRKQRRTGLGPEAVGSLLFRAPSFALAALLWPARCASSQWESLPMTLMAVGLFRWAAGLWGYSGFQQPPMYGDYEAQRHWMELTTHLPVSQWYFHDLQWWGLDYPPLTAYHSWLLGKLGALINPAWFALFTSRGSDDPDLKIFMRASVIVSEYLIYIPATVAFVRRFGRLSGVGSWASSIALAAFLMQPATILIDHVHFQYNTVMLGLVIASMNSMLAERYKSAALFFVAALGFKQMALYYAFTVFSYLLSKCLLPTVNPTRLVSVSLTTLLSFVALLSPLVLGALYDNYRGLDSRPDLDTAPPPLPLLPFLANYLDTRSASYAVIEQLLQMIHRVFPFSRGLFEDKVANFWCAANVVFKLRSLSPETLQRASLGATLFSILPPNAIIFFRPRKSTLPLAFAATAWGFFLFSYQVHEKSVLLPLMPMTLLLAGRNGLSSEYRAWVGFANLLGAWTLFPLLHRVSLGIPYAVLTLLWAYLLGLPPFSWDALWELPDGQSALVRWGTILIHGTFYGAMGLWHIIEASFPPPLDKPDLWVVANVGIGAAGFGICYLWCLWKLVQGSDLLPTGRAAKATKAKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5N8</accession>
    <name>A0A367L5N8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_3934</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5N8"/>
    <dbReference type="STRING" id="1330021.A0A367L5N8"/>
    <dbReference type="OrthoDB" id="6415790at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008521">
        <property type="term" value="F:acetyl-CoA transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035348">
        <property type="term" value="P:acetyl-CoA transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000289">
        <property type="entry name" value="Acetyl-coenzyme A transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024371">
        <property type="entry name" value="AcetylCoA_trans_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004752">
        <property type="entry name" value="AmpG_permease/AT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778:SF9">
        <property type="entry name" value="ACETYL-COENZYME A TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 33 ACETYL-COA TRANSPORTER -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13000">
        <property type="entry name" value="Acatn"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="519"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI09745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="557" mass="61743" checksum="D012E630CC8D730E" modified="2018-11-07" version="1">MSARARRPQSTEPTQSLSAEADNANGKMHSGFEMRRKGGSPKTGNMALNVMSRDGFSLDEPVPVPTPAGHGSRGFLELPRQDQRNFLLLVLLYFLQGIPMGLAMGSVPFLLKNHLSYGEIGTFSLASYPYSLKLLWSPFVDAVWSRRMGRRKTWIVPIQFLSGLGMLWLGSRVEDMMQTMGRPGGPTVWGFMLWWFFLVLMCATQDIAVDGWALTLLTPANVSYASTAQTVGLTAGHFLSFTVFLALNASDFANKWLRTVPSEAGLVSLGGYLKLWGWAYIIVTIGLALLKREERSHNEDGVWEVYRTMWGILKLRNVQAIIIVHLIAKLGFQANDGVTNLKLLDKGFGKDNMALTVLIDFPFEIGLGYYAGMWSQRYTPMRLWCWGFVGRLAAAVLAQFTVMVFPRDGVTTGYLLLVIGEHVLSTFTNTVMFVAISAFHAKVSDPVIGGTYMTLLATVSNLGGTFPRYFVLRLVDALTEATCHPAKGAETEPFSCAVQAAKEQCEKAGGRCEVLRDGYHAVNVLCVAFGVVTFFWYIRPKVMHLQALPLRAWRLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5R4</accession>
    <name>A0A367L5R4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ketopantoate reductase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_3914</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5R4"/>
    <dbReference type="STRING" id="1330021.A0A367L5R4"/>
    <dbReference type="OrthoDB" id="73846at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050838">
        <property type="entry name" value="Ketopantoate_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765:SF2">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="5">
        <location>
            <begin position="163"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="6">
        <location>
            <begin position="319"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="146"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI09775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="474" mass="53256" checksum="31E2546560B38E20" modified="2018-11-07" version="1">MRANRARADRGSSNKPRKSDPSSGTPTRTDGAKADTVFPDKPRKTISPSDAPGKENRVRVDRGSLDKPPKPDASSALAAVKPIHAPNPKFALLPASTALPPAPVHKIHIIGEDAKAKFMAHVLCDIYESVELLGWRRISSKYSNISSGAERSKRKSTTPWPSPTGLKRNAVPERKLAKDDSSHIDLLVVTGPACDAAAALNSIKHRVDDKSTICLMSEGLGVMSDVKENIFEHVDSKPDFLLGYMSHKVAWHRNSDSVKRLKDGETRVTHPISDFELKKVVRHKSPPRPTRVDTWSSSHDLCSSVTAYDEWLQFKMPGMIFDCCVEPVCTVLELSYKNVMWNQAAQSLINKLLNEILNVIKHMYEIQGSPVMRSLVNHQRVSSWLRRSILAKRDQPCQLVKRIEYGLPTDIEYRNDYFIRRARQMGIYPRTNATMSDIIKAKQIQALARINSQVRFEETTIPGHLEEQYRSLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5X2</accession>
    <name>A0A367L5X2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAD4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Outer kinetochore protein DAD4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L249_4175</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAD4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5X2"/>
    <dbReference type="STRING" id="1330021.A0A367L5X2"/>
    <dbReference type="OrthoDB" id="5516652at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013959">
        <property type="entry name" value="DASH_Dad4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28222">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28222:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08650">
        <property type="entry name" value="DASH_Dad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="15" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCI09819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="91" mass="10512" checksum="3EBAF76F061FCA17" modified="2018-11-07" version="1">MTQLISLYERDTIITATTNKESPHEHQQNLLLSRIITNVEKLNEAVVMMNKSLQEINIQNMNVELVAQMFKNYQSNVLFHLEATDNLKPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L702</accession>
    <name>A0A367L702_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein transport protein SEC13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Protein transport protein sec13</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L249_8512</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L702"/>
    <dbReference type="STRING" id="1330021.A0A367L702"/>
    <dbReference type="OrthoDB" id="364224at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090114">
        <property type="term" value="P:COPII-coated vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032008">
        <property type="term" value="P:positive regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032527">
        <property type="term" value="P:protein exit from endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000017">
        <property type="entry name" value="SEC13 homolog (S. cerevisiae)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF2">
        <property type="entry name" value="PROTEIN SEC13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="11" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="6 13" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="52"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="14">
        <location>
            <begin position="93"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="209"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCI10210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="304" mass="33451" checksum="1FC4D4D093F87A99" modified="2018-11-07" version="1">MMANTGHDDMIAEQKHDAVLDYYGRKLATCSSDRTIKIFEIEGETQRLVETLKGHEGAVWCVAWAHPKYGNILASAGYDGKVFIWKEQGNSNQWQRIYDFPLHKASVNIVAWAPHEAGCLLACASSDGNVSILEFKDNSVDHSIFPAHGLGVNSISWAPATSPGSIVSSAPSLGSVGNRRFVTGGSDNNLQIWAFDPASQSYKQEREPLTGHTDWVRDVAWSPTVLQKSYIASASQDKTVRIWASDASGSGQWDCKVLNFDAAMWRVSWSLSGNVLAVSGADNKVSLWKENLRGEWECVKTIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7Y8</accession>
    <name>A0A367L7Y8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_4487</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7Y8"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI10543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="63" mass="6962" checksum="18BF4181A4520243" modified="2018-11-07" version="1" fragment="single">RVRSIGSIGLIRSIRSVRSLQVFLQIADLLNPLFPTKFPLSATIGNVEKYSFAKLSGSGNYTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8U5</accession>
    <name>A0A367L8U5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7029 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_5267</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8U5"/>
    <dbReference type="STRING" id="1330021.A0A367L8U5"/>
    <dbReference type="OrthoDB" id="160645at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054293">
        <property type="entry name" value="DUF7029"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22974">
        <property type="entry name" value="DUF7029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7029" evidence="3">
        <location>
            <begin position="187"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI10848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="735" mass="80365" checksum="2D39A7B9FDC437A2" modified="2018-11-07" version="1">MRLIRPTGFNAPVARNTTMPFFSLLALPLSGIIATNGLVSTAWKTDPLRLLLMPESIKMKLHSLSLSLSLSLLFLHHSSAIDPDLDLNPAQAVDGEATPALLPVGMPDRDLMEPNNTQPARRVSMLWVQGTGKGRVKVTGRMRWPTVLLEDIGAVRGVTCEEGMVRVRFGDGDDGGGGDGDGDGDDDDDAFVRARDSWMAHPRFVLVTNALGACDAPAERGIYLANGSAVTVHLSDRRLDVPAQRIDFADAVRTSQVTVKSKRGGARRRRKRVTMDLNPTLDMSGLEVFRFENSSLVADRLRLDASLTLSGKLRLGFFSVEECWFDIRGLAALDLALDLQVDAQLQRTFEQSTPPLTLPLLAVPGIFAVGPAVQLAVGVDVTAMASLYAEAELRMEFVDASWHVDLVDGSRSQSVGMTPVCDVAVRLGGKASLHFDPFVDVRFLLNVRLLSGLLNLNGGIKVVPKLVNAFALDDGHWMSEEKPEAAIDTTHVQPPPLISIVLLDQGKEGEEKDGEPSARYKYDVVDGWQSGGPPRLQYPQSDKSKKRKGKKKRGHQQDKPFDVWQRSNAKSLSVRSTAGGRGKSIVDETDATTEVETVEKSPEQLAAERKAKEGRRKSNEAAAACRDGISLKSEIRLDVIAVLAKWEWNLYRRSAPFFDGCYALPTGASSEGLRLLGPPRCVVMLRRRTREEKIIDARPEGSSAWGRSCPLHARGAAAGKLSETQRDFCRNRKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8Y9</accession>
    <name>A0A367L8Y9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_5225</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the trehalose phosphatase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8Y9"/>
    <dbReference type="STRING" id="1330021.A0A367L8Y9"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01627">
        <property type="entry name" value="HAD_TPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000036">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase subunit Tps2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1020">
        <property type="entry name" value="Trehalose-6-phosphate phosphatase related protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00685">
        <property type="entry name" value="T6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF123">
        <property type="entry name" value="TREHALOSE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="78"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI10891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="835" mass="92644" checksum="889E9392F56FD393" modified="2018-11-07" version="1">MTRRESLAELQAANPELALSGNIISVTFDLPYALTYRKGGDWKLKPRRGQSALFDALAHLSSDATPWNHTVVAWTGEIESPSPSDAPSAADVNGLDSRLPTPPPSDGLRIVWLADDDDDDDGGGNGVTLRDQTRWRRYAQHELFVLLHYQQNEPTDGRRERVQWADYYRMNQHFADRVLEVYRPGDVVIVHDYPLMLLPSMLRRRAPAMYISFFLHCPFPSSEFVRCLPRRKEVLEGVLGANLIGFQSYSYSRHFLSCCTRILGFPSDTLGIDTYGSRVQVGVFPVGIDTAKVESLAWSDSVSAKLDALRALYAGKKIIVGRDRLDSVRGVTQKLQAFDRFLELYPEWRERVVLIQVTSPAGRNGGDDGEEARVGNRVHELIMKINGQYGSLGFSPVQHYPQYLSQDEYFALLRAADIGLITSVRDGMNTMSFEFVVCQKHGRSPLMLSEFSGTATSLGDAIHINPWDLTGVADRIHAALTMPDAARADMQARLYRYVTVHDAQSWMAKLIRKACSVLGEAGGAAATPMLDRAQLLKQYRSAGKRLFMLDYDGTLTPIVREPSAAIPSERIIHALAMLAADERNAVWIISGRDQDFLGHHLGHVPRLGFSAEHGSFMRHPGSDQWFNLAEKLDMGWQTEVMDVFQTYTNKVPGSFIERKRCALTWHYRLADPELGLHMSRECQAELGAGVACRWEVEVMPGKANIEVRPTFINKGEIAKRLVATYHKPRAPLAGKGDVDDVDGEIGFALCMGDDFTDEDMFRSLNGASGTVLKSEGVFTVTVGASTKVTLAKWHLLEPEDVIECVALLAGEQGHTGGVNLAALSTVEGHIPPEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L939</accession>
    <name>A0A367L939_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Retrotransposon Copia-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5161</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L939"/>
    <dbReference type="OrthoDB" id="3599317at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI10938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="23869" checksum="3C8D15BD0D26BA4F" modified="2018-11-07" version="1">MGIISISFSHLLNTNTSPASNSSSIASFRLLPRVQLSDSGYLYTFNLFFTAFLFTFRPTNYLIRTLFSDAFQQSDPLFLKKFPLSATMGNDQKYSFAKLSGSGNYTHWALRMDSLLIREKLQGALGSIAHNKSEDALALIRLQLEDGPLTQIMHLRSAKEAWDKLKDLYNPALRIDSLLIREKLQGALGSIAYNKSEDALALIRLQLEDGPLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L989</accession>
    <name>A0A367L989_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteophosphoglycan 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5356</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L989"/>
    <dbReference type="OrthoDB" id="2142961at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016071">
        <property type="term" value="P:mRNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028322">
        <property type="entry name" value="PNRC-like_rgn"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15365">
        <property type="entry name" value="PNRC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="371" mass="39882" checksum="0C76617DED180862" modified="2018-11-07" version="1">MDRLPSHIPSMPQNHGRKAYASENDAASLHQPQTPNKPSHVAGSPMPASSKQQQTGKSSNKKKARARNTPTSPDSMQRQTPPHGPLYLKPAPNRAAFAGATFHASPAPSALPIPSFVTRSSSDSPLVVHAGAREDATQEPSPPATDTDAPTPLRASSAPRSRESPLDFMFRAHREEKERSGKLSRAASSSSQVAAAATTTRTRLQSQAGAKSSPNLLTTSSEADKHVSRTSPLTGPEPDGLHGLPMGPAFSTPYQERMKAARSDYARRPPPQARRLPDATSNGATPPEDPTEALKKFLFGTPPPTSKNQPSLATPTTGNAHRPQLRKAETLPPEPSRSHDIQAMENDLRRILKLDLNNNHSHSNHHNPPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9E5</accession>
    <name>A0A367L9E5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mpv17/PMP22 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_5218</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI11045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9E5"/>
    <dbReference type="STRING" id="1330021.A0A367L9E5"/>
    <dbReference type="OrthoDB" id="10267969at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF80">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI11045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="25322" checksum="1005FD1303B9447A" modified="2018-11-07" version="1">MTSLVDHKQQVETVLASKRVTTKQFIPTSLTMPSPILIATLQAAGLSMASNLCAQFLDAYQHQHAFVPDPSQLSRFLALTLVTTPPNYLWQQFLERSFPSHPRVSVIASDDIELKAADQTTTTTAPTPIRPLSIRNTATKWFVDCITLGALGNTVAFLLLMGLLKGQPAVHIWHNIRSETIPIIVAGYKIWPLASVISFSFVPVHRRVVFLSFVGLLWGIYMSLVAARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9T4</accession>
    <name>A0A367L9T4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9T4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="70" mass="7508" checksum="155546CCBB948563" modified="2018-11-07" version="1">MKGRISNSPLTCIFPPTLTVPSAPGEGGGVQRARDAGQISGNTGELKGRIFFGPLLSFFLMFPPTNLEKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9U8</accession>
    <name>A0A367L9U8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small nuclear ribonucleoprotein E</fullName>
            <shortName evidence="9">snRNP-E</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Sm protein E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_5253</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in pre-mRNA splicing. Binds and is required for the stability of snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site. Involved in cap modification.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI11012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9U8"/>
    <dbReference type="STRING" id="1330021.A0A367L9U8"/>
    <dbReference type="OrthoDB" id="25620at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01718">
        <property type="entry name" value="Sm_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027078">
        <property type="entry name" value="snRNP-E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11193">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="22"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI11012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="117" mass="12953" checksum="35D1FBD59E1910FF" modified="2018-11-07" version="1">MTGRGGGGGRRVLLPPINMIFKLLQSNSLVRVWLYEQLSIRIEGKIRVRSSPPFSPFHEGEADGSRAQGFDEFMNLVIDDAYEVKQDAKKPGGEGEERKPLGQILLKGDNVSLIQSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9V7</accession>
    <name>A0A367L9V7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9V7"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="95" mass="10267" checksum="1EB2136BE6C0771F" modified="2018-11-07" version="1" fragment="single">PKARHNALSHSRAIARSSQRSARCTYSGHSTRLISAQGSRHIDRRAVLIAVIALDQSDRRAVLIAVIAPDLDSRTKGALGSKTHNKSEEAGLEQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LA29</accession>
    <name>A0A367LA29_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7221</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI11275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="86" mass="9642" checksum="1E8BCBA373733BE5" modified="2018-11-07" version="1">MEAFIQRNNFVEVSLPLFVKPGEPMKPPLLVSFREQRSEGNQPHMYQARLILSSIDGKPQDPXCTVEEGQGCRVPGGLTDKWCTVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LA67</accession>
    <name>A0A367LA67_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Signal recognition particle subunit SRP54</fullName>
            <ecNumber evidence="14">3.6.5.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Signal recognition particle 54 kDa protein homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">L249_7771</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.4" evidence="14"/>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LA67"/>
    <dbReference type="STRING" id="1330021.A0A367LA67"/>
    <dbReference type="OrthoDB" id="10250817at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17875">
        <property type="entry name" value="SRP54_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.30:FF:000003">
        <property type="entry name" value="Signal recognition particle 54 kDa protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000022">
        <property type="entry name" value="Signal recognition particle 54 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.140:FF:000001">
        <property type="entry name" value="Signal recognition particle GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="entry name" value="Signal recognition particle, SRP54 subunit, M-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006325">
        <property type="entry name" value="SRP54_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01425">
        <property type="entry name" value="SRP54_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 54K PROTEIN SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF5">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="Signal peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="17">
        <location>
            <begin position="845"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="537"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00035672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RCI11317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1062" mass="117814" checksum="83EFB2F3F438974C" modified="2018-11-07" version="1">MATPSTPVRRYAVIPSGSATQLSRSVKRMISPSSTQSPSQKSILLVASDESPHQPGQQLDIGTYFPPRQLFPNNQAEVSPEPATWHTANVLVPFNMRDLQVSLEEGEPMRILHSIFPQTIHVMESVPRRWLNFYVRQLPSTPWPVAVGGLPITICTNTQGRGPFFPAKRRQGNLGISLFQDLNGRAEDYFSLEDFRSLAATVHRYFLAHHENVKLCEIITTMQNEIVVVLDGDGFAINLLAPKLPGKIAKCFVGYLHESELHRPLSRSDSRARRIIRPDHFSRVSDNTAYDVIRPGVMLWSDRLLTHAHPFTMTTTAGVLIQSRNDQMFLTGASHGFGDDRVVYQLRADNSKRIIGEAIHEITHTDVALVKLRDDVSAENVTFEDQNGNVPTFVRLLGEKASDLSPKSKYPEMVFLNSPFSGVVEGITVARSIKIESENAAEQRVRFVPYSWSFTGQVEDAGDCVRAPPEGVCGSALWDDEGVVRGFFQYFIAEGRYAGFSVSADASELVEAGYRLAQYFVRRWQYVYPTPVAFTDVPRPRSSRTPSSGETSEHLSGFHVQSSSHLSSREVDGLLVMVLQDLGRRINAAVTNLTREQNLDEKALDSMLKEICAALLEADVNVRLVGQLRKSIKSSVNFKELPPAVNKKRIIQKAVMDELVNLVDPHVDPFKPKKGRPNVIMFVGLQGAGKTTTCTKLARHYQARGLRACLVCADTFRAGAFDQLKQNATKAKIPYYGSLTETDPAAVARAGVEQFKKDKFDVIIVDTSGRHRQEAALFREMVDIQHAVRPDETIMVLDASIGQQAEAQAKAFKEAADFGSIIITKTDGHAHGGGAISAVAATRTPIVFIGTGEHMLDLERFAPRQFVQKLLGMGDMAGLVEHVQSLNLDQKDTIKHLQEGIFTVRDLRDQLSNIMKMGPLSKMAGMIPGMGNIMQGMDDEEGGAKLKRMIYICDSMTDKELDSDGKLLAEQPTRMTRIARGSGTSVREVEDLLTQQRMMAGMAKKMGGNMKNMQRAQQAMGGGNKAHSWPRCRSGYRAWAAVEEEDQAEEDWEEGVCRTWAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAQ6</accession>
    <name>A0A367LAQ6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Poly A polymerase head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_7692</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAQ6"/>
    <dbReference type="STRING" id="1330021.A0A367LAQ6"/>
    <dbReference type="OrthoDB" id="445712at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052929">
        <property type="term" value="F:ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052927">
        <property type="term" value="F:CC tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3090.10">
        <property type="entry name" value="cca-adding enzyme, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032828">
        <property type="entry name" value="PolyA_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734:SF5">
        <property type="entry name" value="CCA TRNA NUCLEOTIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734">
        <property type="entry name" value="TRNA-NUCLEOTIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12627">
        <property type="entry name" value="PolyA_pol_RNAbd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81891">
        <property type="entry name" value="Poly A polymerase C-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly A polymerase head" evidence="7">
        <location>
            <begin position="56"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA nucleotidyltransferase/poly(A) polymerase RNA and SrmB- binding" evidence="8">
        <location>
            <begin position="237"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI11501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="551" mass="61977" checksum="14B700348EE6696D" modified="2018-11-07" version="1">MEPQPKKPRTDQTRPMTSRDGTISLLPAEKLLRELLLDCRSHIQKSGLAAANNLEMWITGGWVRDRLLGIPCSDVDIALSTMTGSQFGEALTEFFHLEANNGFRDQASDLGLETPSVFTGFHTTKQNLRKSKNLETTIGKVFGLDVDLVNLRKEVYDDDSRTPTMEFGSAEEDAFRRDATVNSLFFNLDTQKVVDLTAKGLDDMAAGIIRTPLEPRKTFMDDPLRVLRLIRIGSKLGYTVEEATRRSMGDADIHAALSVKVSRERVGIEVFKMMRQPNPQFALQSLFEADLYHTVFLERNSAVRKALQQRLPPQEAERPWPMTWPRAYRLLTRLLADETSELGRMLHAHESVECLWLMAAYAPLAELRQDMLKKAVAVAAESIKATNKHSKLLDQALRNVDSIRDTIVLVDGQQDKRPARGSIGMTMRAWGDTWRPQVLFSLLAQVVYDTTSPSSLPSAEEDTALKSILNQYNAFLAFVTRESLQDVCAIKPLLDGNAIMDLFGRQQGGRYLAKAITELVAWQLENQTLGIEEAKEWLLQQKDRMGIPATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAW4</accession>
    <name>A0A367LAW4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA ligase</fullName>
            <ecNumber evidence="7">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_7563</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="7"/>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAW4"/>
    <dbReference type="STRING" id="1330021.A0A367LAW4"/>
    <dbReference type="OrthoDB" id="206088at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07900">
        <property type="entry name" value="Adenylation_DNA_ligase_I_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07969">
        <property type="entry name" value="OBF_DNA_ligase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3260.10:FF:000004">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000018">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF9">
        <property type="entry name" value="DNA LIGASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="10">
        <location>
            <begin position="501"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="590"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="723"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="834"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="84"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="596"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="616"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="723"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="843"/>
            <end position="854"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI11559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="854" mass="95118" checksum="F9921390A36A80E8" modified="2018-11-07" version="1">MSSPLKKRKLNNGSKSQTKSLEYFFSKQRQNTTSTHAVTDEELALKLQAEWNREECVNGASSDGLKKEYGSECFDKTQDANPPAQASTSTLSLQSADTAEDVVNSSIPLDESPLTFDPSKYVPRLKECWASEGGSASYGLLTRTFVLVSATTSRIKIVDTLVNCLRLLIDGDPSSLLPAVWLATNSISPPYISLELGLGGSAISKALRKVCGLDNRALKAVYDKFGDAGDVAFEAKKKQSFTLRKPKPLTIKGVFQSLVTIATSQGQGSNEAKQRIVDRLLQDARGGEESRFIVRTLCQHLRIGAVKTTMLIALSRAFLLSRPPNADFPLKPISELAALKKEEMAEVWGKAEEIVKACFARRPNYDDLVPALLEFGATEELLARCALTLHVPLRPMLGSITRDLSEMLTKLQGRDFTCEFKYDGQRAQIHCDEQGKVSIFSRHLELMTDKYPDIVELVPKIRGEGVDSFIMEGEVVAVDGETGELMNFQTLSNRARKEVSIDAIKVDVCLFSFDLMYLNGQALLDRPFRERRELLRSMFIEIPRRFTWVKSLDATSGDSEAVLDFFKTATDSKCEGIMVKVLDAAPRCPRDAEGREAEDDQEAEDQAAEKLTTPSKSKRKQKIKKGTADGGEKRRRKPLLPTYEPDKRLDSWLKVKKDYSSSFDTIDLIPIAGWHGQGRKAKWWSPILLAVRNPESGSLEAVCKCMSGFTDAFYKANRAYYDDDDDDDDDDDDDDGGEGGKKSKKTRAQKPSFVDYAGPSPDVWFEPHEVWEMAFADVTQSPTYRAAIGLVSDERGLSLRFPRFLRKREDKSVEEASSCHFLAALWRKQEAKVLTEREPGGDAYEDEGDDGDGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LB23</accession>
    <name>A0A367LB23_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_7759</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LB23"/>
    <dbReference type="STRING" id="1330021.A0A367LB23"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF6">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="468"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="72"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="496"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI11615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="532" mass="58301" checksum="B55E39341ACC1DCD" modified="2018-11-07" version="1">MRNEEDGQISLSASTSATSAAGPSSPPSHQPLLVPATMKKRAGEDTVEPMPEMDPEQRARTEKRLKRKLDARCAIFVLIYIMNYLDRQTISAARLKGLQDDLRLDNTQYATCLSILYAGYILMQVPSNMLINRIQRPSLYISAAMILWGLVSTLSGVAHDFVSMLCTRFFLGFVEAAFLPGALLLLSKLYTRRELTTRNAILYCGNLISNAFSALVGAAVLSNMQGVLGHAAWRWLFFIEGGTTMVIAIAAAFILPDLPHNTRGFTAEEKIVAQLRMTDDVGEADADSHGQGVFDGLILALTDVKVYVVMLTVTAYVLGLSFNAFFPTLTGTLGFDYVPTLLMSAPPWLFSCIVSVLVSLHSDASQEKTTAPFFKFWHVVGPLILGIVGFAISMSTLNVAARYVALFLQAASYAGYIVFISWISSSFPRPPAKRAVAIALINAVSQVGNIAGSYVWDLKEDGYRKSYGIVLVMFCLSIAGSCVFRAMLGRLNKEMEAHERRNPTQPPPPPPSAMGSRAEDTLRMKKGFRYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LB91</accession>
    <name>A0A367LB91_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7572</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LB91"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI11681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="94" mass="10671" checksum="1DFD0EE31D9BF651" modified="2018-11-07" version="1">MPSIWGYSGYSARSTRYSDRYSDRRARSISRYSGYYSNRYSDRRAVLIAVIAPDLDSRTKVRSSGYEPGFSYLIRDTNKLSTNFSPPSSSSTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBE5</accession>
    <name>A0A367LBE5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_7618</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBE5"/>
    <dbReference type="STRING" id="1330021.A0A367LBE5"/>
    <dbReference type="OrthoDB" id="332281at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009316">
        <property type="entry name" value="COG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024602">
        <property type="entry name" value="COG_su2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12961:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06148">
        <property type="entry name" value="COG2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 2 N-terminal" evidence="10">
        <location>
            <begin position="33"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="183"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="183"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI11734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="297" mass="32692" checksum="90DF41853F0F3954" modified="2018-11-07" version="1">MAHVARIPSPALSSTDDNDDDDTPLPFPAALPRSDFLASEFHPAAYLSALPHRHQTLEDLRADLRDRSSAISAELLELVNANYTAFLSLGSELEGGDDRVEGLRVALLGFRRAVDEIKANVSRRRCETSALNAKLRRVRLSVSRARAMLDLSDRLSALEERLAIRPEGQAQTDESVTVDAAAADDDDHDDAEDTEDSDADEHSHGLLGSPPAKLLQSARECRRLQALAAALDAQHPFVAKMQRRLSRCRSTLLLDLSNALKEARGAGHGGHDRVMRYLEIYRVLESPREAVKALRSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBI9</accession>
    <name>A0A367LBI9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Delta(24)-sterol reductase</fullName>
            <ecNumber evidence="2">1.3.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_7710</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.72" evidence="2"/>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBI9"/>
    <dbReference type="STRING" id="1330021.A0A367LBI9"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000246">
        <property type="term" value="F:Delta24(24-1) sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050614">
        <property type="term" value="F:Delta24-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000031">
        <property type="entry name" value="FAD binding domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040165">
        <property type="entry name" value="Diminuto-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801">
        <property type="entry name" value="24-DEHYDROCHOLESTEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801:SF10">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14300)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="8">
        <location>
            <begin position="1"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI11602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="493" mass="56010" checksum="F8675DF306270DC0" modified="2018-11-07" version="1">MERHKEAVAVIAAAIRGFFQRKESFRIAHGSTNSTRPQHRPGARVVDISSLSRVVSVDGASRTALVEPNVPMDRLVEATLREGLVPPVVMEFPGITAGGGYAGTAGESSSFRHGFFDATLNRVEMVLGNGDVVSASPTDRSDLFRAAAGAVGSLGVTTLLELRLVKARRWVRTTYHRTSSVSEAVEAIRAETKNPDNDYVDGILFSPTHGAVISGRMTDEKPDDCEPQTFSRAWDPWFYLHVRDRSQVKAETTEYIPLAEYLFRYDRAGFWVGAQGWTYFRLLPFNRFFRWLLDDFMHTRMLYRALHASGESSRFVVQDLAVPYEKAEELINYTTHNFDIWPLWLCPLRQAPTPTFHPCSGAVPVEQDVLNVGLWGWGPSDHEAFISKNRALEDKLVELGGRKWLYAHTYYSEDEFWRVYGDRGWYEALRAKYHATTLPTVYDKVRIDVKAAREERAASPWKSTWPFGGLYGIWKSIQSGDYHLHRNPGWKHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBJ9</accession>
    <name>A0A367LBJ9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inositol polyphosphate-related phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_7659</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBJ9"/>
    <dbReference type="STRING" id="1330021.A0A367LBJ9"/>
    <dbReference type="OrthoDB" id="2248459at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000036">
        <property type="entry name" value="Inositol polyphosphate phosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF240">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE 5-PHOSPHATASE C9G1.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inositol polyphosphate-related phosphatase" evidence="2">
        <location>
            <begin position="753"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="383"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI11781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1145" mass="125989" checksum="97FE6C0BF11920C4" modified="2018-11-07" version="1" fragment="single">METAAAEDGPDGSSIKPVSSLLARFENMNSGSQQQEQSRPLSPAPKPERLRSFKPAAHDVAPAPKTPAKIPDRLVADRTGNARPSARPCSTIKPLGISLQPPAVTVQAPPLSPEGASPIAESHSPFLDPPGREARVAPSKSNKMPGQPMSPHAPTIKPPRPCLSNPPSPPPPRRSAETRKDREGKQAPPPPPAPRSTRARPAPSLPEPRDKADISQAVSPFNSPPNSPPQIHNEPLRELPTRLTGKSIADGAGLEPLPPRRPSFAAKRTEREQITTASARSHLTSPRTADHRLVPDPSRLRGAEDHVNDAHSRPSPVLLQANTHKLEAPPPPPPPPPSDRPISQPASRQAPPLPTRQTNNVRLRERTPNGTRPESGSGSLPNTAASKAPPAAATEAASSSIKAIGAFPDGSNSNRRPPFIRKGCHEIQTRYDARAIDACGELVCTTGQLTRVWNLADGEQTMSLSHTEGVRATAVAFKPAPSADLEGSTLWIGTNLGEIMEVDVATQRVVHTKANLHGRCDVIRIYRHVNELWTLDEMGMLLSWGPDADGVPNLTGHPHQSNKLPRGHTFSMVVGDELWHAAGKAIRIFAPSPASSGPFQVLVRPLTYEGAGDVTAGTLMRTQPNKVLLGHIDGKISIFSTQDYSCLAVLTISSWKINALAGVGQHLWAGYNTGKMCVYDLTTSPWTVRKDWQAHDQSIIKMMADPAAAYRLDRVQVVSLGADNKIRAWDGLMQEDWLEEDMKSRDVEYCDFDEMRATVMTWNAGASTPHSLRYSDSDASFFRELVQSSSSPEIFIFGFQELVDLEDKTATAKRFLKAKKKEGADQERMSHQYRDWRDFLIKALDDYAPGDDLYHLLHSAPLVGLFTCVFVKASLRERIRNVSAAEVKRGMGGLHGNKGAVVVRFQVDDTSLCFVNCHLAAGQSQSSSRHNDVAAILDSTLFPAERDTEARIDSFAGGGDGTMIMDHELCVLNGDLNYRIDTMSRDTVVKAVEQQNLAKLLERDQLLMARRRNPAFRLRAFDEMTITFAPTYKYDVGTDTYDTSEKRRSPAWCDRLLCRGRGRIQQLDYRRHEVRVSDHRPVTGNFRLWVKKVEARGRAVAWMESQQRFEDVRQRETDDEQISYLVHTCGYDQASSEKFVAERSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LC77</accession>
    <name>A0A367LC77_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="8">PPIase</shortName>
            <ecNumber evidence="8">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_0532</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="8"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LC77"/>
    <dbReference type="STRING" id="1330021.A0A367LC77"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000032">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF385">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="9">
        <location>
            <begin position="77"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI12038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="237" mass="25777" checksum="507E92B213089F4E" modified="2018-11-07" version="1">MRSTLLLRPLLPRYNLCPLGSRAFSPLHLTPSLQKPSRFFSATSAAMGSIKCFFDVQWTGPVFKDGKATNEVKDQSGRINFNLYNDTVPKTAENFRALCTGEKSFGYKGSSFHRIIPGFMLQGGDFTRGNGTGGKSIYGDKFADENFKTLHSRPGLLSMANAGPNTLVFPHASRVVNGSQFFITTVVTSWLDGKHVVFGEVADPESMKVVQAIEGTGTQSGSCKYDKRPTIVDCGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCF0</accession>
    <name>A0A367LCF0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_0881</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCF0"/>
    <dbReference type="STRING" id="1330021.A0A367LCF0"/>
    <dbReference type="OrthoDB" id="38531at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057688">
        <property type="entry name" value="DUF7928"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408:SF3">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25550">
        <property type="entry name" value="DUF7928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="283"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="682"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="721"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="762"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="815"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="845"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7928" evidence="4">
        <location>
            <begin position="71"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="3">
        <location>
            <begin position="492"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI12097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="874" mass="98090" checksum="6B824C3D151E7869" modified="2018-11-07" version="1">MGLGSYFGAGKSGSKVATAGEDAAARQESGRSEKQGDDRLMPPTPRFHSRPQSSSGRSTPSTHSSVFLDDIKHEVMVNYLYQQQCSQLWVSDGSGEMEGVLLRKARGHYMACPPRLGTSAFAIACAAMNLQCAMTVNSRVIKSFLQWSPDAVDVPLMNGLRIQILPTLDDLPRARKHQFAAFVASEGLLIVWDDDPLHLVQRARAIESELMELVWKAGGNDGGDADDDDDMDEESGEIRPERRRRRPVHLQNSVLVALTLVLVVTSLGAAWRQLAIQVSVDGSYTRLALVALCPLQIFFSLFFAQVIVGCLAQILGPIRQLKINSKFYSARPPPRLQTATLPHVTIQCPVYKEGLQAVIVPTVKSIRQAMSTYELQGGSANMFVNDDGLQLMGEEQRRARIDFYADNSIGWVARPRHGDNGFRRGGKFKKASNMNYALMISCKVEHRLQALQRPADWSQHDEALAYEQALNDVLDGEDGRAWADGNIRVGDYILLIDSDTRVPADCLLDAVSEMEQSPDVGIMQFSSGVMQVVHTYFENGITFFTNLIYSAIRYTVSNGDVAPFVGHNAVLRWSAIQQVSYRDDDGYDKFWSESHVSEDFDMSLRLQCSGYIIRLAAWAGDGFKEGVSLTVYDELARWEKYAYGCNELLFHPIRTWLWRGPFTPLFRRFLFSNIRFTSKITVISYIGTYYAIGAAWIMTAVNYFLIGWFNGYLDKYYVDSWQVWFSIIVVFNGLGNVALAVMRYRVGERSLMALFENFKWTLMLAIFLGGLSLHVSQALLAHMFEVDMTWGATSKEAEFSNFFIEVPKVLKKFKFSMLFSLTFIIAIIVLAVGPFIPHDWRITDFVAILPMATVSASHFLLPLALNPALMTFSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCI8</accession>
    <name>A0A367LCI8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_0384</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCI8"/>
    <dbReference type="STRING" id="1330021.A0A367LCI8"/>
    <dbReference type="OrthoDB" id="343582at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16982">
        <property type="entry name" value="CID_Pcf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000016">
        <property type="entry name" value="mRNA cleavage factor complex component Pcf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045154">
        <property type="entry name" value="PCF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054127">
        <property type="entry name" value="Pcf11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047415">
        <property type="entry name" value="Pcf11_CID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021605">
        <property type="entry name" value="Pcf11_Clp1-ID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921:SF3">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX 2 PROTEIN PCF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21936">
        <property type="entry name" value="Pcf11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11526">
        <property type="entry name" value="Pfc11_Clp1_ID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="2">
        <location>
            <begin position="4"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="607"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="364"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI12140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="652" mass="71185" checksum="A11D4030F97FEC9C" modified="2018-11-07" version="1">MASDADEVAEDYRHALEDLSSNMRFEISNLTVIARENTEHALAIAQVLQQHILKAPPSKKLPALYVLDSIVKNVGTPYTLYFGRHLFKTFMESYAVVDHNVRRKMEEMLRTWKDPVPGSMDTRPVFSHELVRPIENALIKARAVLMPQQPGPIPGRPRSAMLPRRDTPTPPTAPVPGQAFAHPSGTRPGELAALGPQRQFVDNGSAPAFAPAAMFAQYPQHAALPFQPGPYGGISVETLNNDIQNLIVAMKAEFSHNPHDASVQNRLRALLDLQGVVQRASLPPDQLELIKNKVTELAAVTMRPSSAQNVAHKPALVPHLQALAPSPQPVSSSSAPPAPLSQAPVTLDSLLGPGALATLLARQSTTATTTTPTPTQNSPPYQAPVLTERPKTTGAPPVNPIDLLGQLRQAGILPPANAGVGGQPSMPPLNTASLLSSAKVAAAPNIHQTLDPVALKRRFNPESVAALYDELGTPCRQCGRRFTTDEEGKKRKTSHMDWHFRVHQRSNEAEKRGTHRSWYVDQQDWVRCREVVDSDHIAAPEETSKEATQTEKGPRFMAVPEAGSGVHNVCPICQEKFENKWLDTAQEWVWLEAVLVGNRAYHESCHAEATRDREGTPAVLSSRRSPEQVVLGKRKAETSISSPKVRAMKTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCK2</accession>
    <name>A0A367LCK2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_0385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCK2"/>
    <dbReference type="STRING" id="1330021.A0A367LCK2"/>
    <dbReference type="OrthoDB" id="2119228at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01833">
        <property type="entry name" value="XynB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051532">
        <property type="entry name" value="Ester_Hydrolysis_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383:SF5">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383">
        <property type="entry name" value="THIOESTERASE 1/PROTEASE 1/LYSOPHOSPHOLIPASE L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016793764" description="SGNH hydrolase-type esterase domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="2">
        <location>
            <begin position="67"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI12141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="317" mass="33978" checksum="241F1B78F7F36537" modified="2018-11-07" version="1">MRAPLLAAACCLLRLTAAGPGAALQKTLNPRLLARSNATSDSVLNPRQNLTAPGDKLKPGPQLRVLCTGDSITAGTFSELDGGDGNGYRLRLRENLSSGVSADRVVFAGTETAPQGTMSDGFFAAWPGKTIKFMTDHIEPSLKQRPNLILLHAGTNDMNADPAISTEGNDPTEAVKRLGTLVDRMSDSCPDAVVLVAMIINTCVPAQAPRTQEFQRQIPAMVQQRFEDGRRVLAVNMTSFPTDQLRDCIHPTNDGYRLFGDYWSDVVTQVPEEWLEAPAEANSAEDPAASPANRSGVPQWRLAVTLAAAAVGVLTAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCR2</accession>
    <name>A0A367LCR2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GH64 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_0150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCR2"/>
    <dbReference type="OrthoDB" id="10058186at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09220">
        <property type="entry name" value="GH64-GluB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.50">
        <property type="entry name" value="Beta-1,3-glucanase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.110.10">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032477">
        <property type="entry name" value="Glyco_hydro_64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037398">
        <property type="entry name" value="Glyco_hydro_64_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042517">
        <property type="entry name" value="Glyco_hydro_64_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037176">
        <property type="entry name" value="Osmotin/thaumatin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38165">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38165:SF1">
        <property type="entry name" value="GLUCANASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16483">
        <property type="entry name" value="Glyco_hydro_64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52006">
        <property type="entry name" value="GH64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017074585" description="GH64 domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="GH64" evidence="2">
        <location>
            <begin position="70"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS52006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI12201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="452" mass="49292" checksum="2EBEE2F5E11C4036" modified="2018-11-07" version="1">MVRLRSATCLLGLTSATLALRGRGYSAFSVVKPGGIDDVLVTEDNMMTGTFHGNKTRVVHQHRARRADDEAALTLELVNLYNAKQTINAYVTGLDGSNRVVFVRADGSMVYPSSGGSETPVLIKESVAIPLTNGSQRMPLPTALYGGRVWFADGQLQFYMVKTPYGDGMVQPSVMNLRDPSAAVNWSFAELTYTRERSVFANISYVDFVGLILSMALKQRNNRGTQTIRGLDTDAVTKICSGMVDQSDNDGFPWSRLCVADDTGTPIRVLSPNSYGTINQADFGQYWDAYVDRVWEQYRQTALVIDTQSAAGQVECRVSPGNNTLLCGGGDNRGYKKPSANDIWGCNSGPFERLPDDNGVHVAVIPRLCAAFVRSTLLLAGGNIQPRLNATHYYRDTSASHYSRLIHELELEGRGYAFPYDDVNPEGEADASGIVASGEPDTLTVYVGVPPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LD83</accession>
    <name>A0A367LD83_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_1297</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LD83"/>
    <dbReference type="STRING" id="1330021.A0A367LD83"/>
    <dbReference type="OrthoDB" id="5353066at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="641"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="682"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI12393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="709" mass="78363" checksum="B1FDF1011D14B9DC" modified="2018-11-07" version="1">MKPTTLEKDSPFLFPFPRSGEARNVAVDPFRPKQAAEPDMADLGNGIKQQLDDDKEWETEADDDDRVFSTEATTKPNNCARAASRISRRLDSSARSTQPSPIAHPATRCSEQHIHCSSIYSEASKGDEHAVDQPPGRLDCSLQEHNNPRPLPPATLWPQRSTSGGGETAWSKTSSSISMERFKFDRGMYSLLMSSAEREVSNTLDCARISTDTLVTVIEQPPKKIKPGPELSSIDHNVPVIKGECANPREEPVQSPVPTKNSLDTDGDWQTITTERPHEPIREIELNFAKGAGSSLADVSDTSADDVRNAQLDDLSAKAGYLAQSTLDEFGLARQCNHHLAPPRANTGHASHVFQMPQRPARAAEAIRCFSNPFRQDFAPPPDAAFEMAKLSNSYDSLESGPIEVCRKGIRYSNKLGQDPPKLPSVMFDRQSNWPSFRQSTGYKEEGLVSRDTSRLPFPLISLPEAARLQSFRRERGQEDHTDPPGFFAARVRSARSATVSTMSTVNSPMTPLSAYVDWQANMSPRGHGRARAACPGHGLPRQPCSPNPFHSGSPRPKTGRKLFGQDVSDSSSIIEARILRLRGFAMSAREIRAGIGHESSELSEIELMERGRGRALHGGQPGKTTTPLRVLFWGIRVTTVIFPLVGILALCGHFDSTISWYSRGQRHSLLTRQRFILKRQLLVELVMYAVLITALVVYYSLHGQRSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDN4</accession>
    <name>A0A367LDN4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Succinyl-CoA:3-ketoacid-coenzyme A transferase</fullName>
            <ecNumber evidence="3">2.8.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_1189</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate</text>
            <dbReference type="Rhea" id="RHEA:24564"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35973"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.8.3.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 3-oxoacid CoA-transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.5" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDN4"/>
    <dbReference type="STRING" id="1330021.A0A367LDN4"/>
    <dbReference type="OrthoDB" id="1933379at2759"/>
    <dbReference type="UniPathway" id="UPA00929">
        <property type="reaction ID" value="UER00894"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008260">
        <property type="term" value="F:succinyl-CoA:3-oxo-acid CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046952">
        <property type="term" value="P:ketone body catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1080.10:FF:000001">
        <property type="entry name" value="Succinyl-coa:3-ketoacid-coenzyme a transferase subunit b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012792">
        <property type="entry name" value="3-oxoacid_CoA-transf_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012791">
        <property type="entry name" value="3-oxoacid_CoA-transf_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014388">
        <property type="entry name" value="3-oxoacid_CoA-transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02429">
        <property type="entry name" value="pcaI_scoA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02428">
        <property type="entry name" value="pcaJ_scoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707:SF60">
        <property type="entry name" value="ACETATE COA-TRANSFERASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000858">
        <property type="entry name" value="SCOT-t"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="5-glutamyl coenzyme A thioester intermediate" evidence="4">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000858-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI12535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="538" mass="57600" checksum="3F1219A77193D330" modified="2018-11-07" version="1">MASTLVLPLPVPVISISTRLSRASRRVKKTTTNFALRTFVTTTHRCSQPAQRKTSKVFENANHAVADVKSGSTVLSSGFGLCGVAETLIKALKRRGRDNLHSLTAVSNNAGREDLGGLTHLTESGQVKRLILSYLGNNKWLEKNYLGGTVAIELCPQGSLAERLRAGGAGIPAFYTPTGAHTLLQTGGIPTRLDTSGNVTEGGKPRETRDFSGRTYLLETALTGDVAILRAWKADKAGNCVFRYTARTFAPLMAKAARLTMVEVDEIVEVGEIKPDEVDLPGIFVDRVVKSTEEKAVEIIKLRDAADDGKPLKASSPAEERRMRIARRAARELKEGYYVNLGVGIPTLAASFIPEGRTVWIQSENGILGMGPYPTKSELDFDIINAGKETVTLLPGASCFDSAESFSMIRGGHINVSILGALQVSAAGDLANFMIPGKIFKGMGGAMDLVANPDGTKIVVVTEHVAKDGKSKIVQQCQLPLTGARCVSTIITDLCVFQVDRTKGSLTLTELAPGVSVEEVRAKTEADFGVADNLEAME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDT1</accession>
    <name>A0A367LDT1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histone H1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_0107</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Could act as an H1-type linker histone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the histone H1/H5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDT1"/>
    <dbReference type="STRING" id="1330021.A0A367LDT1"/>
    <dbReference type="OrthoDB" id="1110759at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00073">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000383">
        <property type="entry name" value="Histone H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005819">
        <property type="entry name" value="H1/H5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00624">
        <property type="entry name" value="HISTONEH5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="8">
        <location>
            <begin position="18"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="76"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="108"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="204"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00055135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI12585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="217" mass="22055" checksum="C8DADEBED90B6509" modified="2018-11-07" version="1">MPPKKVDSAAKPAAAKPTHASYQDMITDAIVNLKDRNGSSRPQLKKYVKANNQLNVSDNMFDALFNKALKNGVEKGVFAQPKGPSGGTKLAKKKVEPKKPAAKKDAAAKAAAKKTSAPKKAAAAAPKKAAAAAATASAPKKDKAAATPKKAASTPKKTAPPKKAPAAAPATAPQAEKLETVTTKTKSGRVTKAVKPAAKKATPKKAAAPKKAAAAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDY9</accession>
    <name>A0A367LDY9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_1236</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDY9"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI12630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="74" mass="7937" checksum="5658692BFB6FD433" modified="2018-11-07" version="1">MDGLMDGDWRGDYIGGASAAKAGLERVKGSKGRRRTQGAGRIQALRPAIWGYMPSQSHVATQGPQAPQQFALPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDZ2</accession>
    <name>A0A367LDZ2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_1235</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDZ2"/>
    <dbReference type="STRING" id="1330021.A0A367LDZ2"/>
    <dbReference type="OrthoDB" id="42889at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF146">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI12631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="467" mass="52455" checksum="3C5FA37E2D2E9291" modified="2018-11-07" version="1">MADDQIESLLAWATRQGALIHPSVQVYRSPATGLSLRVKPTVAAGPDPSEAILRVPTSLTLSYLDASSPTSSFPPELAAGLPPHVVGRLLLIRQYLLGPSSFWWPYIQALPQPKQADQSWRLPPFWPPDDVDLLDGTNVGVGAAQIRQDVAAELTLARELLRHQDGQDAVALAEALRAPDLYHWAYCIFSSRSFRPALVLSPSSHQHSLLAERGASLDDFSVLFPLFDIANHDMTAHVEWRLDDKFSQSCELRVHRLHAPGAQIFNNYSLKTNAELLLGYGFILPVTDEVHNDYVHVRKRGTATSDYLISLRPLAQPSSLLVRSRDRQSPCKSDDGVLGAFRHVQPDLVWDIFCTMAPLERLARLIPTQEDEGDDNKDFEYERRRRFLTGRVAGDCRPYLEQTMALVQHKVVLELERLNETDLEVVGADVDLLSRNQRLALDYRARCRRVLENTIEAMEGFAVDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LE22</accession>
    <name>A0A367LE22_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LE22"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="185" mass="19883" checksum="A0A5E8A1C250062B" modified="2018-11-07" version="1">MPSRSFGAKACLSRRKPHYSLVQLPSARFSRSIMNFSVIVQALLVGLGSAASQEVNVKGCDLQGASPPRGDTGVCPAAGQSCEAFCADLYNQVVLNVTSEESVNSTDQEQKAESSADQQPPCKSDSNIVFPSDSEKQKKETMDMDSLVGNGNQLQGLLVKMKMDHPYAFVLTFAALYILSRDSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LE41</accession>
    <name>A0A367LE41_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pheromone receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_0601</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LE41"/>
    <dbReference type="STRING" id="1330021.A0A367LE41"/>
    <dbReference type="OrthoDB" id="5402633at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038038">
        <property type="term" value="C:G protein-coupled receptor homodimeric complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004932">
        <property type="term" value="F:mating-type factor pheromone receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000750">
        <property type="term" value="P:pheromone-dependent signal transduction involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14939">
        <property type="entry name" value="7tmD_STE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.920">
        <property type="entry name" value="Pheromone alpha factor receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000366">
        <property type="entry name" value="GPCR_STE2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027458">
        <property type="entry name" value="STE2_TM1-TM2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28009">
        <property type="entry name" value="PHEROMONE ALPHA FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28009:SF1">
        <property type="entry name" value="PHEROMONE ALPHA FACTOR RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02116">
        <property type="entry name" value="STE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00250">
        <property type="entry name" value="GPCRSTE2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="319"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI12502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="393" mass="42714" checksum="0A4A65A75C059C19" modified="2018-11-07" version="1">MVYVPAEPASILSELPPKPTPGFDPWSQTVAFYGSDAKTIIGVPLSAVDNFSDETASMSISAGVQIGACTISLAALLILTPKAKLRRPMAVLQIIALVLVLARSGFQASDFVAPTVHFYIWWATDYAGVPRGVTYKTLASHVVTMFVNIAVEAALMNQAWTMVTLWPAMVRKALIVTSAFVAAALVSLRILFAVMLSRADLMGWPRSSLSWIMTTTLIANTLSIFWFCAVFNVKLVLHIVSNRGLLPAARKLTSMEVLVMTNGILMVIPVVFAGLEWGHFRNFEPAFLTNSSVAIILPLGTLAAQRMGTFPTNAHYRNPSAAPESASSASQRFRAGHPSFRKPSLSNSSGSPCEPAQVARQSRVDDAFDLELRRIDSEAFTMDQKMGQRCEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LE57</accession>
    <name>A0A367LE57_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L249_1258</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac. The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination. Recruitment to promoters depends on H3K4me. Also acetylates non-histone proteins. In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LE57"/>
    <dbReference type="STRING" id="1330021.A0A367LE57"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046972">
        <property type="term" value="F:histone H4K16 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF219">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="16">
        <location>
            <begin position="111"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="143"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="14">
        <location>
            <position position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCI12701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="480" mass="53573" checksum="033262DCF584E677" modified="2018-11-07" version="1">MPPKRKLPPTTAEAPPSQPQEPQAPGQRASRKTPLPVSDRFREMRRGWGRGGPSELVAPEITYHVPQQQQQQQQQEGFSALVRPLGPTQQQQQESSKQKKKPSSTALPPPRADRNIDKVVLGNLCFRTWYSSQYGKEVFDNNVYNTNSNNNNSSSNSHHNNSNSNTTQAMTSSSHKREPPRMLERLYVCPCCFKYARELVAWRGHVRLCERRRHVPGHKIYVHPRTRRRREDGKDSGEGFKRRRAESCVDHLAESEGEWSIWEVDGDKDGLEKGFGGEELVVVGSLTSFELFCQNLSLFAKLFLDNKSVFFDVSGFNYFLLVYTPPTRLLPPPGSNLGPPAPQVTGFFSKEKLSWDSNNLACILIFPPWQRKGLGSLLMGASYEISRREGVIGGPEKPISDLGRRGYRRYWASEIARWLLGVEVGSVGGEGGVVISIGDVSRATWIAQEDCLAVLREMGVVEDGGGGGVEGVPRSNDGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEK9</accession>
    <name>A0A367LEK9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_0707</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEK9"/>
    <dbReference type="STRING" id="1330021.A0A367LEK9"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="886"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI12857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="945" mass="106090" checksum="8F9894A9BF9D6BFF" modified="2018-11-07" version="1">MQNRDSQHRPSMRFHFDDDQTAEAYIEPDVSVDSGVDPFFDSASLSESVLDFPQEFGRTYHAYRAGSYAFPNDVPEQERLALQSSIIKRLFGDRLHFAPLDPVRPPRVILDVATGLGDWAIEMGDLFPGSQVIGTDLSPIQPDIVPPNVSFFVDDATDPWCHDQPFGYVHTRLTGGCWGSFEKEIAEPAFASLEPGGWFESQEIDGLVFADDDSLAADSAMHRWFQEVATAAERLNRPANLGHSLREVYERVGFVDVHEHIFKMPTNGWARDERLKELGRLWERNLLQGLSGFSFQLFNRAYDRTVAQIEVSLVDVRRELSDPTPSSRPPRSNPPSITILHALAGPPRHVSQGKVAQARWQANAALSYVQLTLSRHNGTNSNTCQRPIYYATGGLLPSRLRPSACVCMYKPDGPWPRLLSSKRATPTIMALWLALGALAVYLLVRTIYRLRFHPLANIPGPRLTAATHLYEFLYNVVRPGVFLFEIEAMHRKYGPIVRINPREVHVSDPAFYHVIYASSRRRRDKDPQFVPTYGLPDAMVAAVSHDQHRVRRAALSDLFSRRAVVERSGLVAERVERLMQRLSEARDAGTVVSLDEAFTAMASDVITAYACGRHWGSLDDEHFGSEVCRATADVMRFAHISRFAPYLVALPRLVSPRAMALLMPAKAALFRHLEAIFDHVRGTSRDAPGSSDTVITALTDPILPPHERSVSRLRDETWAIVGAGTETTARVLTVAAYHLGRNPDVARKLRAELFTVLPELDSTASWAELEQLPYLSGVVHESLRLAYGLTGRLPRVAPTEALQYKGFVIPPGVRLRTFFFYPDDTLMLMCCLDQTPVSSSSYIIHRDASIFPDPETYDPERWVRASNKGDHLKRYLTSFSKGSRSCIGINLAYMELFLTIAHLGRRFDLELYDTGPEDVRIVKDMNMGFTRRGAVRVFAKVTGDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEQ4</accession>
    <name>A0A367LEQ4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_1341</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEQ4"/>
    <dbReference type="STRING" id="1330021.A0A367LEQ4"/>
    <dbReference type="OrthoDB" id="539158at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000692">
        <property type="entry name" value="Serine/threonine protein kinase, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="18"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI12905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="524" mass="57822" checksum="E44AD16650A26C30" modified="2018-11-07" version="1">MMRKKSQLDPLPPDLPFRIVSKTIGRGAYASIKKAIPLDASTPVFAVKLIHKRYATKHGRVSAKQLAMEVSLHSHVGQHPHIIEWFASGEDPVWRWIAMEYAEGGDLFDKIEADVGVRQDIAQVYFVQLVAGVSFMHSKGVAHRDLKPENILLSSDGCLKLADFGMATLFEYKGRRKTSGSLCGSPPYIAPEILACGRGETVDAQYAADAADLWSCGVILFVLLVGNTPWDEPSPANWEFSNYVHTAGHSTDALWKRIPPEALSLLRGVMAVDPARRFGFSQIRTHPWYTRRNPLLTDDGHVSDPIILATQMLESLRIDFSQSPLASQPADPMQIDTNLGKLPSTQPETPITDKAWDWEQPVLRAAAGPASSLPSRAAVLGVLADEPSMSQFSHTPGPSLTLTQQARRFRDICPAESLTRFFSHVPVAHLVQMLGDALHQLNVPSSPVSPNLSSSPVANIKVKALDGRQQSLHGEIKIHKQLLHDGSEILDVRFVKIKGDPLEWRRFFKSIVVLCKDGVYVPDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEY2</accession>
    <name>A0A367LEY2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="7 8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_0264</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the PPP phosphatase family. PP-Z subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7 8"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEY2"/>
    <dbReference type="STRING" id="1330021.A0A367LEY2"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07414">
        <property type="entry name" value="MPP_PP1_PPKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000006">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011159">
        <property type="entry name" value="PPPtase_PPZ/Ppq1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF484">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE PP-Z1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000909">
        <property type="entry name" value="PPPtase_PPZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="10">
        <location>
            <begin position="334"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="187"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI12983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="544" mass="59240" checksum="E8197F6A24414456" modified="2018-11-07" version="1">MGNQASKDGGGSSTKGSASAGEGHFQSYPSFSRSDTRESSRSFRSLRSKIPGGVKSDSPRNSAVLTNSDTPADKAADAASVRSGRSGRSSMSRTSRGDLPPLNRTDLPHARHNSADLTQDSFAIFEDQPPPSPISASALRGGNHDVSAAQASGEVDHVSDQPPSANAGINTHMQAPGQPILMKRDSVVSPAQGGPSADSPPKADANGNTAVAMADIKDIDLDDFIKRLLDAGYAGKVTKSVCLKNAEIVAICQRAREVLLSQPALLELDAPVKIVGDVHGQYTDLIRMFEMCGFPPMANYLFLGDYVDRGKQSLETILLLLCYKLKFPENFFLLRGNHECANVTRVYGFYDECKRRCNVKIWKTFIDCFNTLPIAAIVAGKIFCVHGGLSPALSHMDDIRNIARPTDVPDYGLLNDLLWSDPADMDQDWEANERGVSYCFGKRVINDFLAIHDFDLICRAHMVVEDGYEFFHDRVLVTVFSAPNYCGEFDNWGAVMSVSSELLCSFELLKPLDSSALKSHIKKGRNKRQQMLNSPPASVQPQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LF27</accession>
    <name>A0A367LF27_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_0995</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LF27"/>
    <dbReference type="STRING" id="1330021.A0A367LF27"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000165">
        <property type="term" value="P:MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06620">
        <property type="entry name" value="PKc_Byr1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000253">
        <property type="entry name" value="MAP kinase kinase Ste7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000261">
        <property type="entry name" value="MAP kinase kinase Ste7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049613">
        <property type="entry name" value="Byr1-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050915">
        <property type="entry name" value="MAP_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE STE7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="65"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="352"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="362"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="436"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="466"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="482"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI13034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="507" mass="55585" checksum="4F673861345B2666" modified="2018-11-07" version="1">MADPFAPRSMKRKNVKGLALTPAAPRPPPTAETSRPDADAGRDENKDGQLEIGIEYKLDLRPEDLEILKELGSGNGGTVSKVKHLTTGTVMARKVIHVEAKKEMRKRIVRELQIMHGCHSDYIVNFYGAFLNSNNDVIMCMEYMDVGSLDRVSRVFGPIRVDVLGKIAEATLGGLTYLYSKHHIMHRDIKPSNILVNSRGSIKLCDFGVSGELINSIADTFVGTSTYMAPERIQGEKYTVKSDVWSFGLTIMELAIGKFPFAASEQLSDDECAPAGILDLLQQIVHEPAPQLPKSDAFPSILEDMIQKCLYKEPEQRPTPQELLDRDPFVQAAKRTPVNLREWAVGLMERDNRKSHLAPQLSPATQDLLRSNSDSPTYHKHAEERPAHTPTSGEIPIGGAGVVSPRDHSSRSPSRNGFGNSRTPAAAHPGLGPRGATTNSIPQVPRYLNSSAPLGANVTTFNLPVRPAPPNVPLPPAPARKQTPDESRKEMRRQATFGLPPNPSYGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LF58</accession>
    <name>A0A367LF58_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_0696</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LF58"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI13059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="70" mass="7606" checksum="368647851309D80C" modified="2018-11-07" version="1" fragment="single">YLSGRSNVCIHGLEPPEQLTDDIYPSRIGSRNHQALLAVIRPASPTALIPRGVSLFSVACVWLLSGFASW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFX7</accession>
    <name>A0A367LFX7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0324</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFX7"/>
    <dbReference type="OrthoDB" id="10635410at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="182" mass="19977" checksum="D8EF466D5E94DCB6" modified="2018-11-07" version="1" fragment="single">MYTTINPLPPSRSPRGQSIVASSIRNGTSEDAQQRPLRTPPCSSLVACTDSASRLVPNHGKQRQKYGKNGQSVNLGRPVMHPWRPSLEGKEKQEKKKGEGEGEDEDEDENDDEGGICTIIRGEKKGETTRNKCTVVGTIKKKDVMRWVVVGFAPRGNISQVKASRMDARSAWTAKPGSFNVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LG10</accession>
    <name>A0A367LG10_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Anaphase-promoting complex subunit 4 WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_0325</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LG10"/>
    <dbReference type="STRING" id="1330021.A0A367LG10"/>
    <dbReference type="OrthoDB" id="4096at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000234">
        <property type="term" value="P:positive regulation of rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053826">
        <property type="entry name" value="WDR75"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23869">
        <property type="entry name" value="Beta-prop_WDR75_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="353"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="604"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="865"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="865"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="877"/>
            <end position="921"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI13327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="967" mass="104489" checksum="B30F051786117DA2" modified="2018-11-07" version="1">MAGQNSPQVKDNKAQKRKREAGESETKSKRHRHGRRHNQDNANKKPDRCTATASDSLVKKSQDLSHHSGSGWRISKPMGGRILDIDPILTADERFLILLYNTSVQVYNASNSLLIRRIPICSLDASAPPGSSPASITAARLSSENREFIWVACSDGAVYHVDWTVGKEISPTFRTASRTAKAMVVVPFASEGNGEMIIIAESAKDHCMAVIAYHCQAGSVSGSKTIHTQTSKKRAKHESGLHLLEASRDGKVLTGALSDCLFVCVASGAGEGEFSQVQYKAFSFEVPEIITTIDIRMHAETSLLQGNDMASNEEQSDAVDIIVGGARGNIYVYGDVVSRAQSAAKDGISVSKLHWHRKAVHSAKWSRDGNYIISGGSENTLVLWQVDTSKKNFLPHLSGTVENIVVSEGGSSYVVHLDDNSVMVISTAEMEPTAYVSGIQSAVAEVMTPKDLLVKRCFTVTDRVRRPVPAAINFKESSRLHICVGNGRQGTMWGDFSAPLLQTFDLHTFASVGKQALARTRPTEVNATAQGHTIDEPLITHIAFSGDGKWLASVDEWKPAEGDLGYKLDEQIMRERREVYLKFWQVSDGDEPMTLASRINDPHGTSQSETVLGLAANPATTDFATIGSDGTIRLWRPRARKQAQGVTAGDNALFWRCTWLAEVGAGSGRELMTDAASGEARKAQGSIAFSEDGSTLFAAFGAGDSGAVYVIDTASGEVVRMLDGLWSGQLHAISVLSSFLILLSQELRVYDVVSDELRYGIVVPKTSEVHELLQLATDRSSGHFAVALPKGSSSSVGVFHPDDPEPLLVRSIPHRIVSLVSAPSASGFVAIDDVAQVWVVTEGSDPTAVATVQSLQDLRLDGLTEADGHGGIHIGEDEGAESDAEMEDKSGEEEEEEEEEEDDDDDDDDDEGEDVVMDDSDWTPTAVPRQYLADIFDAAPAFAAPSAEEMFYKVVDLLARPVPMASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGR4</accession>
    <name>A0A367LGR4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Calcium-transporting ATPase 2</fullName>
            <ecNumber evidence="2">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">L249_5550</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. Transports the calcium to the vacuole and participates in the control of the cytosolic free calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="2"/>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LGR4"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000018">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006408">
        <property type="entry name" value="P-type_ATPase_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01517">
        <property type="entry name" value="ATPase-IIB_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093:SF369">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24093">
        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="360"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="805"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="871"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="945"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="977"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="22">
        <location>
            <begin position="90"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="20">
        <location>
            <begin position="188"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase C-terminal" evidence="21">
        <location>
            <begin position="824"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1033"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1129"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1245"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1039"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1052"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="1077"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1129"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1250"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1281"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="23">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00059328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00067965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="RCI13587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1321" mass="145200" checksum="88D022D492ED433B" modified="2018-11-07" version="1" fragment="single">LHTLVNFRNLATLDDFGGLPGLAAGLRTDVVAGLNADEAFLDGTLTFDEAVAAGRHGRASILAALESPPPSHHGPASVEADVDPDSLRFADRKRIFGTNRLPRRRHKSFLKLLWVAFNDKLLILLTITALISVAIGIYRSLSVEVGNSSIEWVDGTTVVIAIIVIVLASAFNDWQQNHRFEKLNERKNQRQVTVVRSAKPQRIWNHELLVGDVLHVEAGDILVVDGILVQAAGLHIDESPVSGESAPVRKTTPSDHNASHTGLADPFVLSGTTVTCGVGRYLVTSVGASSTHGRTLMSLREDVEETPLQAKLGRLGKQLIIFGAVVGGFFFVILFIRYLANLKQMAGYSPSRKAERFFQIVTISITLVIIAVPEGLALNVTVALAFAAKRMLKDNNLVRLIRSCEIMGNVTSVCCDKTGTLTQNKMNVVAGRIGTEGAFDDRQVPIRRGNQGVNSSRLVASLAEEVKDLVKDSMALNSTAFESDDPAAAASGFLGSSTETALLVFSRDRLGMGSLREERANSSIVTMLPFESTRKWMAVLVRLSHARYRLLVKGAAEVVFEFCAYVLCDVTDELAAERLSEDERTTLGLTIQGYAENTLRPVATAYRDFDASEVFESDDDDPADVNLEWLASGLIFIGVFGIRDPLREEVADSVRKCQAAGVFVRMVTGDNFLTARAIAAQSGIYTPGGVAMDGATFRRLSPTQLDAVIPRLQVLARSSPEDKLLLVSHLRAMKETVAVTGDGTNDALALKAADVGLAMGIQGTEVAKEAASIILLDDNFASIVKALSWGRTVNDSVKKFCQFQFTINITASILTVSVLVGLPIFTVVQLLWINLIMDIFASLGLATDLPSSECLRRRPEPRNAPIISITMWKMILGQSIYQLVVVFTVHFAGWDIFNPNTQFEMEKLQTLVFNIYVWMQFFNQHNCRRVDNKLDIWYNVLRNPWFIGVQCITLVGQFAIIFQGGEAFDTVPLTGAQWGWSLLFGLLTLPLGALLRQVPDRYVSKLFRLLYRIVLAVGRSLRPISACISRFTRPRRRQGRQESHDDARHQTQNETTPSSAQAVGALSIPDPAARHSMGSNNVEESSENWTRLETSSSLDEGDEKVDLQALIDAARVGRTAGRHWLELHPGTLKDDPILGRRSDINLPPSQDPALQIPQPGDRWMEDGSGEAKTGRPXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXPGTLKDDPILGRRSDINLPPSQDPALQIPQPGDEMDGRRLRRGEDRPTWAEPRCSPPTAHSRWLSLEGFLRSNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LH10</accession>
    <name>A0A367LH10_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_8154</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LH10"/>
    <dbReference type="STRING" id="1330021.A0A367LH10"/>
    <dbReference type="OrthoDB" id="10264728at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031416">
        <property type="term" value="C:NatB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:protein-N-terminal amino-acid acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000058">
        <property type="entry name" value="N-acetyltransferase (Nat5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051646">
        <property type="entry name" value="NatB_acetyltransferase_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="2"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI13723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="190" mass="22093" checksum="9D5325C0C8F78EDE" modified="2018-11-07" version="1">MATFRRFEYGDVNKFSRCNLDPLTETYDMGFYLHYYAKWPSLFYVCEDANGNITGYIMGKVESSPDAYKYSKNYLPWHAHITALTVAPEARRLGIGKILTEMLEAAADANDAWFMDLFVRKSNRKAIAFYKSLGYSVFRVVREYYGDHATDSTKSSEDALDMRKAMKRDVKKQHIRDDGIFHEVDPEDVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LH61</accession>
    <name>A0A367LH61_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_8311</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LH61"/>
    <dbReference type="STRING" id="1330021.A0A367LH61"/>
    <dbReference type="OrthoDB" id="425534at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF25">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016819046" description="AB hydrolase-1 domain-containing protein" evidence="3">
        <location>
            <begin position="34"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="100"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="5">
        <location>
            <begin position="434"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI13750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="562" mass="62801" checksum="2FD0EB10F76CCFD5" modified="2018-11-07" version="1">MESLRPSAATHGPCRVARLAALVVILVCATAQAVHPDCGTIRFYAGEKIGWKPCGEAKGREVECSDINVPMNQFGPPGADGMTFNIPLIRMRGKNGTQNLLLNPGGPGESGLVFLHTDGASLHDVVGEDYHLLSFDPRGIGLSRPTASCYPTRDTRRSRFRFTDPDPFSQSVTRFAWTKNYVQSCADTMKGYGKYINTPQTAADMNSILDAVGQKQMLFWGFSYGSLLGQTYAQLYPDRSSRVIIDGVTDFFDWYEEPILRGDFVDTVNVLDGFLDECAKAGATCALAKHGSTKKELQQKLMGFLRNLSAHPMPVYVDVFKQGVLDYSTVLNEVIYSSLFAPSTWPLLARRLAQVMDGNATEVFLAHGDYDLGEKRRTEGNDEVNDIVEINDGLSGPEHWPEGRKGLVNMLKPWYDSSPFFFQMNREYYAKQQWTIEKGHSFVPKRKVRTTHPMLIISTTYDPICPLVSAKRSQEVFENSSLIEIKGYGHCSLSLASLCMAKHLRRYLGNGTMPESSHSLCEADRPYFPVLTEPRLAVEEEPRISSAQVALAEVSRMRRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHH8</accession>
    <name>A0A367LHH8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">L249_8204</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HRD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LHH8"/>
    <dbReference type="OrthoDB" id="7759664at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16479">
        <property type="entry name" value="RING-H2_synoviolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057992">
        <property type="entry name" value="TPR_SYVN1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058051">
        <property type="entry name" value="Znf_RING_synoviolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763:SF184">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SYNOVIOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25563">
        <property type="entry name" value="TPR_SYVN1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="594"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="620"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="689"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="729"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="763"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="872"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="19">
        <location>
            <begin position="937"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="503"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="994"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1256"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="786"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="1102"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1026"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1273"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1362"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="1376"/>
            <end position="1387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RCI13893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1407" mass="154679" checksum="90393208C3F86628" modified="2018-11-07" version="1">MCCLPMPSARQAILTQSRALQRSIIRCVPDGSGVPAAVIRLSGTAFRPLDSGCRAACSEPGPYFSASDPNATLPARLKLLIKHSPVFEHNTGQEFRPYSLGMEHVIRMYGYVCKYYVVYIHVHAHILAVAIRLEECQRITYLTRSELHIGLRTHGYCFSCTDHLCVHMRMHTHTCRSVNVVAASEEASPLCNLVRTLGFNLVLFVQPLIRHHLQRPEMVATRDDHRTEGQITGARRILGVVSASGFAFSTSSLPPYIMNIPASSVIEVPLTQTDDALGFPSFIFIGIPASLSCLPTHDIGPSRLARRLPPTRLSPGQGCHRCAPWHGTHGLEPCLVAHSRCPQLHRLQHVQGSQPLHETQARPNEWTQISVYRHATGVSVALGNSKQQADDIVVSLTPEFVLLFSTLLILCPRHDDEDNLCRAAFCAARESSLARNRAHRGLVSDVRRSKTFVYRRKVQSPESSIGSAWLCLPPNRDGAPPPSASDGPTTSCITWADDFGATSPKAPSAETRSAVNEVEAGRDGVGRHSTPGSQGLVASASGSRRHTTYRPSGQWTARDLVLESAPRHTMTGGPCPLNRSRSSDSWPSMPKMRLGWYAGVSTALAGGVVVSAFLQRANFYSAMVYLAQSNFCLLALVNFSLLLYSSFIYGLTRLCFGTLRAVEVEQLTERAWFAITETCLAMTIFREEIGAWFLVMFTALVTGKVWGWIGDGRVEFLEQQPPPNPRLFHIRLSISLAMSFLYDIWILRYSVQNVIQQARPNMMVMFLFEFAVLATCSWRTGARYVLVLAEQQIIKTQTRKRLLERRQEVREQREALLRQREQAAAAGEDMPANNEPLPSEDDVDEMDIEVPGWAAKGEWVLWLDLLSDMIKLGIYVAFFFMLLMFYGLPIHIMRDLFITSRDFVKRLHALLRYRRAIQEMNRYPDASADDLAQENTCIICREEMRPWDPVANPGAIDRVRPKKLPCGHILHLGCLKSWLERQQVCPTCRSPVTADRPRGGIPVGAAGLRIQFGGHPRPQGQRQPADDAPQGQGDDGPQQRAPREGGGPRIFNLGPIRLGFGTNGQQVRELAQQFGVPHIAGNQQPAAARTQEQSQATLSDNLQSISNMIQQSEQMLQRETQRLHGAQQELQIANLLMAELLRLQQRRQQGQDQPPPMMQPPTVQPPMVHPPMAQPPQPWSVPMNMPFPPGQQVPVPAAGFQPPFPGIPMFPGAPPRSGSPLMARLGTTGATAPIPSGSADLPEGLSLPPGWSMMPLQRLDGSLPNPILPQPQTPLQSGDVATSSTPAASEHPMPASSSLNPTEGPRAVVPPDITAHEPMSTAAAEPAPVVAPSPLMPSWGGSSQLFDNGSRVGLSEPERQQAEPSNAAGPSSAEQADTEEKEEDEEGSSSKGKARAVTVEEALDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHL5</accession>
    <name>A0A367LHL5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ABC transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_8147</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Mitochondrial peptide exporter (TC 3.A.1.212) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHL5"/>
    <dbReference type="STRING" id="1330021.A0A367LHL5"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18573">
        <property type="entry name" value="ABC_6TM_ABCB10_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000095">
        <property type="entry name" value="ABC multidrug transporter Mdr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000218">
        <property type="entry name" value="Multidrug ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF1">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="393"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="416"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="491"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="533"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="266"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="589"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="830"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="849"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="864"/>
            <end position="884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005580"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI13889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="884" mass="95620" checksum="85C1A8B91C324C83" modified="2018-11-07" version="1">MRNSAVKTRVINGLCLAQKYHPSSLDSGCTSHFRVVYCKRFAAAESGFVISTVLPQPFPPDCFLTSKQTPLSTSEWAEDASSTRRHKARQSFNMISAAARRALLTRVAEGLPATARVFPCGQTAQLSQVRCLSATAARKQLIAAPPPPKILLRARGDATPFRFGRPGSPSPLGVALGAFRLFSHSWRGQEKIKTGAGGKQETKADELVTSRDEESLDFKKSEKAAKAAQVNLSARLSKEGKTQSNAGLGEIWRLVKVARPEIRWLALACFFLVIGSSVTMSIPFSVGRVLDLASKGDGNGDNTRLFGLTLNQFFFGLGAILTLGAMANYGRIVLLRIVGERVVARLRSQLYRRTYVQDAEFFDANRVGDLISRLSSDTVIVGKSVTQNLSDGLRSLFSGGAGFAIMVWTSPKLTGLLLLMFPPIAIGAFFYGRAIRNISRALQKNLGTLTKIAEERLGNIKTSQAFVGEVQEVGRYNQQIRRIFALGKKESLTAATFFASTGWAGNMTILAMLIVGGSFVRSGEMSIGDLTSFMMYTAFAGSSLFGLSGFYSELMKGVGAASRLFELQDRKPGIHQTVGVRVVSAQGAIRFNDVSFAYPTRPAVRIFNGLSFEIPSGSNVCVVGPSGGGKSTVASLLLRFYKPNSGTITIDGVDISSMNVKSLRRRIGVVSQEPVLFSGSIAENIAYGNPMAPRADIVSAARRANCNFISDLPDGLETQVGARGSQLSGGQKQRIAIARALLKDPDILILDEATSALDAESETLVNEALAVLLRGRNTTISIAHRLSTIKRSDQIIVLNTEGKVAEIGNYTKLAADPESAFSKLMEWQMSGGEVPEKRSSDSGPHITEAEEMEQEDELEDEEVPEAKQAEKERPQRPDDEAGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHR9</accession>
    <name>A0A367LHR9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription elongation factor 1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_8109</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ELOF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHR9"/>
    <dbReference type="STRING" id="1330021.A0A367LHR9"/>
    <dbReference type="OrthoDB" id="445983at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.190:FF:000001">
        <property type="entry name" value="Transcription elongation factor 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007808">
        <property type="entry name" value="Elf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038567">
        <property type="entry name" value="T_Elf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934:SF0">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05129">
        <property type="entry name" value="Zn_ribbon_Elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="94"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI13984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="122" mass="12896" checksum="3E7B59B1BB0A8D77" modified="2018-11-07" version="1">MGKRKKSSRKPMGPKKADPLPTTFTCLFCNHEKSVTVKLDRKAGVGQLDCRVCGQKFQCAVNYLSAAVDVYGEWVDAADAVARQDTSNAGRYSSTAIITGSENASGGTSGTGRDGYGDAPIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHV7</accession>
    <name>A0A367LHV7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_8302</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA2/NAM7 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LHV7"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001147">
        <property type="term" value="F:transcription termination site sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18042">
        <property type="entry name" value="DEXXQc_SETX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000326">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001152">
        <property type="entry name" value="tRNA-splicing endonuclease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024481">
        <property type="entry name" value="Helicase_Sen1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056474">
        <property type="entry name" value="SEN1_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF495">
        <property type="entry name" value="HELICASE SENATAXIN ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23576">
        <property type="entry name" value="SEN1_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12726">
        <property type="entry name" value="SEN1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="10">
        <location>
            <begin position="1317"/>
            <end position="1560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="917"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1348"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1843"/>
            <end position="1944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1986"/>
            <end position="2046"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1442"/>
            <end position="1502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="918"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="985"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1025"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1851"/>
            <end position="1864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1865"/>
            <end position="1876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1880"/>
            <end position="1897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1986"/>
            <end position="2008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="2009"/>
            <end position="2022"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="2030"/>
            <end position="2046"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI13977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="2046" mass="227700" checksum="9C9B781732E0E97D" modified="2018-11-07" version="1">MTEFNEHLTKWFEEFQKIPPSCHLLCPKISDSDEENYRTLDNPTSGITLAEKEKRIQDGQRRIEITYWNSLIFGFDRYEAGNWLEDYAIRLQTCLKECPDCVFNWHSNRRAYLQKFSERWNEDSMIHIERILDKLDVKRIEESMAWAKKYVDKVEATGVTFKRSLLSPADQSLLLTAVYEALCCVPFFANPDKRTIFQYVFMRLQGRTYLKLGSNDPLPAMTFFLFDFSIEDRFRFATGNWKSVPADSMTELQFDWAVNGGLVRGIADAAKKDISQANSADSHEVQLFWNSINIILRAMTGDLILSRLRSLEVRPGSPSIYDLLFRHVQHCRSEGVLVATISVLTSLLKKAPKAIWDVIGDARPTVITDLIFGSPMYKDLLRQSLGDFWTGFEPSFHEALPFATSWIQPWLQSLNRDRRYDACDVFMHTLFKSLAEDKTIGEPGQAACIRAGFDALTFTLKSFLDDNVQMTSGSTHLYASSAVNLVVKYRGVILRNLKCPGVDNEGWTTLKVAQSAKDLILTAMRLDLKILSDEFYAIQDGKELHSAVVRDSKAYWDCVYEAFDASTERVGLAKDILPCLGPLISLEQFRPFKKVELDKSCKPFNDTFSGIAVVLARLLGVISDFDLTDLNVLFADRLPFQAIIGLSVNGEPDLAEASVSILTSWTGELSRHSALEHMARLHPEQTISSIVWTLDRIVRPPFPWGPIRPLLNTSRSVLQGLVDPTSGVLRTTTVEPKLAAIILRWWNEQWRFVSIGCLSIENWSRYITNAVMMEFCREIMDLADALVAEDGLLATTIAPGKSSKDAMAMILSPLKEHFRGMDNMIRLKDAWLVDKTVGVLCRILTRLRENGLEIGANSRRTITDACVPTRIPNKYLRSTNLNDQQRAELLRALGHQEGVEIVQVDVMPEKAYGVTPKAKTQSKLDVWSKSASGTSAGPKSKSNRDDVMELSRSVDSPVLKQIEARRAKAPRPAKGPDAKAISALKESRRREKAEKAKRDAETIARARQLRGETGRSRSDIMVNSSDEESDADSDGTDAGGQLAALGAGGQKAQDEESARLQQALRDQLRRPVKKDRLVRSVNQMKARLAPRLDELHTTILMWDPFHEGNDPPGLPPASRVATQYSDPRSYRSTFFPLLVSEGWRSFVTSMNELTSQPFAMNIASRATVDSFLEVTFTLPMAPNKERLVSEGDIILVSQAGNPLAEKEARHCLGRIHRITYKKGILEVTYRVASRSNALTPLLVPGSGLHGIKITNMTTIEREFGALESLQHYDLMHEILKGEPSPILRYAEEKITSAMQNWSLNRGQALAVLGANDNDGFTLIQGPPGTGKTKTIVAMVGSLLSDQLSQTSSGMPVGGPSRPANAVQGQGSGRPKKMLVCAPSNAAADELVLRLKAGIRTKNGKSRTINVLRLGRSDAINAAVKDVTLDELVRKRLEGDTTREDARAHRDKLHEEAADIKERLEVLRQRLEEARGKCDHVWVNNYTRQVEDLKRTRANIGRQIEANKDSGDSLAREMEMRRRQVQQEVLNSAHVLCATLSGSGHEMFRSLDVEFETVIIDEAAQCVELSALIPLRRCYKCVLVATQQLPPTVLSQSAARFGYDQSLFVRMQQNHPDSVHMLDTQYRMHPDISLFPSAEFYEGQVSNGPGMARLRRQPWHGSALLGPYRFFDVQGVQEKGRRGQSLVNTRELEVAMALYESLEEKYRGCKLGGKIGIITPYKAQLMELRSRFRARFGDDITDDIDFNTTDAFQGRECEIIIFSCVRASATGGIGFMTDIRRMNVGLTRAKSSLWILGDSRALVQGEFWQKLIEDAKARDRYTCGDVLGMFRRPLEPAKIQEVIDDEEEEASKAAAAATTTTTTTTTPPPPPPPPPPKAEAKALPATTTNNDDNNNSSDQAGRVTSRPGEGPPVIHTGPVPGPGDGSSKKRSLENAPLPAPKRVGDIMTMSGRGFWWRTGCQVWTATNTEQAAAKGPFGDVGAGLDASGAAAGADDSFSGSRSGSWTGSWADDDVIDSTDDDAGEQSASRPPLKRKKPKPSLFMPKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHY1</accession>
    <name>A0A367LHY1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Subtilisin-like protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_7991</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHY1"/>
    <dbReference type="STRING" id="1330021.A0A367LHY1"/>
    <dbReference type="OrthoDB" id="10256524at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1710">
        <property type="entry name" value="Subtilisin-like superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010435">
        <property type="entry name" value="C5a/SBT2-like_Fn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF66">
        <property type="entry name" value="SERIN ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06280">
        <property type="entry name" value="fn3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016743443" description="Subtilisin-like protease" evidence="8">
        <location>
            <begin position="22"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="9">
        <location>
            <begin position="163"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="C5a peptidase/Subtilisin-like protease SBT2-like Fn3-like" evidence="10">
        <location>
            <begin position="624"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="889"/>
            <end position="921"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI13997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="921" mass="99900" checksum="3F2CE4595AE9A7DB" modified="2018-11-07" version="1">MKQPLVKLVLVATASLHLVNATSTISNAYLFELEDGTDVEEFASTVKADFKAGIRRVLDYPIFKGLSVEFADESRVNEVAALPRIRKMWEVEELHMQDGVDAKDISPLDDQPQGKHDEQPIRRSLHDGALLERRAVSNKTVMGPNAHHVSMQIDQLHKKGITGKGSKIAVIDTGVDYTHPALGGCFGPGCVISFGADLVKGEATPMDCSSNGRGTFVTGLIVARSDRFNYVGAAPGAEVGMYRITCNKTFSNDVLIDALYRAHRDGATIISTSFSNPGGGAAGLLTEAASRLTAQGVVVVQSVDENGESGLFSVPEPSGMPGIITVGMVTSPVSPGVYSKATWLADGGGEETSFPVFRNHAHDNFTGEPMELYAVQGNLVPDDAPDLSNKLVLMCVSGGWKAWRDGEWDAQLAPFAAKGAQRVLFYAERMSANADSLKNPPSNIKAVAMITREDGRSLLEAFKTGTKMLVTVFPGADMTAPLHYAEYPALPGPNISFTSSWGPSWDLGIQPSLVAIGGQVLSTCPLKRSRLGFVSRSKPSSAAALVASVVALVAEARGPLDPAKMQNLLMSNSEPQTKFTAKFYRPKPEKPYFEPVAHQGAGLVRAYDAAFSTSLLELETTGLNFNDTEHFVPSLEFTLKNMGNDDVKYQLSHIPAKTVHTYDAYGKNPLKPDNSLSAGWNFPDFAEPTASIDLSERSLTLRSKNSATIRVTATAPEGLDFRRLGAWSGWIAVKGSDGSSLSIPYQGFTGSIRQHRVMEAHGLWLAYRYRKDGFLNVRYCNQTVLILPPPGSKEKARIMFYIKTTLGSPLVHVDVVPVRSGNGTGEASIGEVFGFPKKNFPSYHTDIDDGIHRFITTEWTGLLDTGSYVPEGRYMLVVRALRIFGDPDKEDDWDVSKSPELSISYGSTDPPLTPKCRQQYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LI55</accession>
    <name>A0A367LI55_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nucleoside phosphorylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_8250</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI14090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LI55"/>
    <dbReference type="OrthoDB" id="5142935at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140860">
        <property type="entry name" value="Pseudo ankyrin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="405"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="4">
        <location>
            <begin position="689"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="892"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1043"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1106"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1141"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1174"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1207"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1262"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1265"/>
            <end position="1282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI14090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1500" mass="167352" checksum="C5F3252CE23CCE09" modified="2018-11-07" version="1">MAAQQDTATNARDYSAYTVGWICALPKEQTAATAMLDQIHPELPNPPNDFNIYTLGSIGAHNIVIACLPKGKIGNNAASTVATRLVSSYPSVKFGLMVGIGGGIPPKVRLGDVVVSTPVYEYPGVVQWDFGTAENGGAFRRIGALNNPPSALLTALAKLETKHDMQGSRIPEYLDDLRKNWPALVPKYLRSDFLKDPEDLRFTWNAYILETILNIFWAILGFIHVLRPSHGKTSPATADSSAAQDTTASTSRNFQVHYGLIASGNQVIKDARLRKTIDTNLDGNVLCVEMEAAGLMDNFPCIVIRGICDYADSRKNYDWQEHAAAVAAAFAKELLSVVPAQAVERMPAIERVLDEICADLHVVSDVVGRLQARQHDDEHQVILQWLTSTDYTTKQRDNLEIRKLGTGQWLLDSDTFQTWLKTPGQTLFCRGMPGAGKTILTSTVIHHLQFSYMSEDTIGVAYIYFDYNYREQQNRLDLASSLLKQLSPKGANFPAAVSSLYGQHQNTRSRPSFGEVKSALQLVMAQYSRVFILVDALDECYTTTNTLSSFLDELGTLKAKFAVNVFATSRDIPEVTKKFENGGFGHSVWKEVRATEEDVRLFLEDDLKRLPEFIKEYPDYIETIKAEITKSVDGMFLLAKLHVDSLLDKTSVKNILSATRDLPTGAGAYNKAYELAMKRIATQPSDHLTLANQALTWIVHARGPLSPRELQQALSIEAGQTYFDEEALPDLGLLVSVCAGLVMFDKESEAIRLVHYTAQQYFEKTRKEWFPEAEANMAKTCIAYLLLEDFKDGPSADYGKRYSRYFFYPYAAKQWGNHAREADTLPEEVKQFLVPSVKLDATCQPLLPFFRLPFDFETRKPTPLHFVAIFGLCEAVDISECSESSIEFEDCFGDTPLSYAVKFGHEEILELLLKKRANVDSMELLRMAVYTRRLSMVQTLVRFIDKNQQLKCPSVWDVLSAAVWTDDTAILASLLDGLRTSARGPVFPLLESEMENLHDEVAFVYSRCWCELNGGWLLRYAMQQKRVSTTRLLLDQGAEGDLEDQTTFHYAARHADRSIIELLLDRGADVDEKDCFGRTALAVTNDAENMATLLDKGADIESRDDTGSTPLHYASLGLGTKAFEALLERGAATCIESRDICGRTPLRWAIDYDSFDLAEALIRRGADIDTKDDLGLTPLHEAVDCRDRSAIEFLLDHDADIGAKDALGRTPLQRALVGGHHSAVQLLSKLGIDVRFEAASTTLDEATLDTIQILVERGAHRLDEKDDDDDDDDDDDDDDDDVDMKPVLEDVLLPQRAISPNLDDDISRRLHSRASELASSNTLIARLLSGANADVNSTEGLSRIILHWAAVGGCRPLVELLINNGVHLEWKRGTGRLITMLGSFSHHGALLLERSFERESWTREQKNTQLYCAARWGHAEAAMSVLSDVEVTGDYVDERGATPMIWAAINGLERVVDLLSSRNEATINKRDDSGNGPYWYAWRNRRYEVKMILRSRGARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIX0</accession>
    <name>A0A367LIX0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein YMR-31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_6068</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the alpha-ketoglutarate dehydrogenase component 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIX0"/>
    <dbReference type="STRING" id="1330021.A0A367LIX0"/>
    <dbReference type="OrthoDB" id="2116030at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020373">
        <property type="entry name" value="Kgd4/YMR-31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31601">
        <property type="entry name" value="28S RIBOSOMAL PROTEIN S36, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31601:SF2">
        <property type="entry name" value="ALPHA-KETOGLUTARATE DEHYDROGENASE COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10937">
        <property type="entry name" value="Kgd4-YMR31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="21"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI14350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="14985" checksum="FF33B3DEBDF3C8BB" modified="2018-11-07" version="1">MLATRFLRQAAAHADRTPMIRFLGPRSIPSSVDHTPKPHPASPTGSLPESFSAYGNSSSASRHSSFSSYRDHAQQHGPLQKSIRSSEVGIGGSPGSQLGPVEPSKGVYFALTELPSRFHRVPFETAEIEAIESGGAALFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJ37</accession>
    <name>A0A367LJ37_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RNA polymerase II assembly factor Rtp1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_6144</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Tango6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJ37"/>
    <dbReference type="STRING" id="1330021.A0A367LJ37"/>
    <dbReference type="OrthoDB" id="39591at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019451">
        <property type="entry name" value="Rtp1_C1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019414">
        <property type="entry name" value="Rtp1_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039600">
        <property type="entry name" value="TANGO6/Rtp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20959">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 6 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20959:SF1">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10363">
        <property type="entry name" value="RTP1_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10304">
        <property type="entry name" value="RTP1_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA polymerase II assembly factor Rtp1 C-terminal" evidence="4">
        <location>
            <begin position="577"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase II assembly factor Rtp1 C-terminal" evidence="3">
        <location>
            <begin position="850"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="698"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="894"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="707"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="724"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI14446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="914" mass="99688" checksum="599539C002199F29" modified="2018-11-07" version="1">MTIAEAPPTAAGGPDSNDARSSCNDYPMAENQTPVAPQPTIAQDIVNAATKAFNPTSTPESREAGLEEYNGIVAGAATWVLLPVLNSLIKPNLLPPWMREHLLQSLTLLPLRPDGVRSTLEFVFSVHPSGQGSDSAQPQKNGASITHEAVAVGTKLLSSVPPTMTPEAWFRAISGQLLDLLDGGAGKDLAKVVAQIVGFGILGQRQFGAPGAPGWEVFVQPLIEAVNPSLAPEKGRPVDAESDGEVTTLSLDRVIVPAQRLGTALHRLSVLVLSNSSPGLCRRMLKPIIVQLWALASWSQQAEAAEGRFISPARSLVQTYLQLFGKLDSISPIVDDLLCTGGDGPPHPPWCFRLTTDGKMESALRPQQSENVSLVWNEVEHKASVLVGIMASVCSSTDVGTVFLHYLDRWIQTAREQDRVQIKTVAQGHDSISAVRQLVEVTLLQRLMIQAPEKLVGHVQQLIEVICQVLVADGRSPVGDDVVSVVLSLLNLVITAPGFQRNKMGAEQTKTIEDALTRLGVEDRPEVSATAKNLGMLLRYRDELEGAGDGDATAKARHEEDEKTYRLAMSYINGDGDKPPPVVSEGINLLSKLMVAESPVLDIQAVAVLMSSLLKETDDFINLRVVKAFTLLANKHPKTTVQELLDGYLDAQEKWSTDVRLRFGEALAQVIERLGETFCGPVANQVCESLMSIAGRRGQRPKTMAKQAREERLQGLKRQRAEAMDEDEEEEAETTDRERENRAMLAQIVEGWEGKRGSEDVRMRASALSILGAALETNICGVEATVVSNAVELCVQVLTLERGPELGILRRAAVVGILSLVRALDRAREEKRQLGLVLTETGRAELQSRLSYVGETDEDGLVQQHARDAMESLESWREREREKETWTARLQMRAHGAAGSDLMQGRRPRIEEME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LK31</accession>
    <name>A0A367LK31_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LK31"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="89" mass="9830" checksum="58F98F5CA678D568" modified="2018-11-07" version="1" fragment="single">RSIRSIGLTRTSLPPNHRSSKYVRVLQVGTLKYLEKIISISFSHLLNTNTSPASNSSSIASFRLSRDSSSSSLLRDYLPDSSTLHPLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKB4</accession>
    <name>A0A367LKB4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal recognition particle receptor subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_6706</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SRP receptor beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKB4"/>
    <dbReference type="STRING" id="1330021.A0A367LKB4"/>
    <dbReference type="OrthoDB" id="41266at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019009">
        <property type="entry name" value="SRP_receptor_beta_su"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09439">
        <property type="entry name" value="SRPRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="71"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI14839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="288" mass="31036" checksum="DC1BB8EC6C1A2869" modified="2018-11-07" version="1">MASSLVSLIEALLTPSLPVLLLGLVIVFCGPVVLHLLLSSSTSYTVPPSIVLIGPEGAGKTSFVTLLERGSGPAQTHTSQTCHSVELNASTDSDSRQSFRNHDDDSGTHTKFLLVDTPGHPKLRSVAMGSLAREKKIRAIIFFVDASALAEHDTLASSASYLYDLLLFFQRRNAAKPTARTSIPILVAANKMDLFTALPPASVRSRLESELTRIRASRNKGLLNSGDDADSEDQDVWLGEFGSSDFAFQQMGEFNIDVDIVGGSVVARGADGPHVNGWWQWMAQRVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKJ4</accession>
    <name>A0A367LKJ4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_6943</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKJ4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016727416" evidence="2">
        <location>
            <begin position="19"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI14897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="177" mass="19924" checksum="7F954AA1D3A1B1F1" modified="2018-11-07" version="1" fragment="single">MAGFLGLVAIFAQAIVHCNDAPGLLYISPGLPRRVASHDGPSKKGIASSWVYSRHPREGISLYSEGQRFVPGVGWKFSRRQELPWRGRWATWIVARETSIPRPRPEVKSSCLDIVRAPRQAQSENRKRNPREPRLAQREKKKKVLDAIRRVSDRSLRGGESPSVEIEASREPGRLGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKV2</accession>
    <name>A0A367LKV2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_6807</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1330021.A0A367LKV2"/>
    <dbReference type="OrthoDB" id="5422283at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024771">
        <property type="entry name" value="SUZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024642">
        <property type="entry name" value="SUZ-C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12752">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51673">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51938">
        <property type="entry name" value="SUZ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUZ" evidence="2">
        <location>
            <begin position="129"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="domain" description="SUZ-C" evidence="3">
        <location>
            <begin position="301"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI15066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="356" mass="39817" checksum="61E08F0A811F9BAC" modified="2018-11-07" version="1">MCKKHSKLDPSIPATFPDVINSPPREHTQRGRRGGKENALQKREENKTKKRLEYHLSHRKPGMKKTLAVPDAWDDDWETQADDAAAVRDDATTPVQEHQNQQPLTKAERLMQHAEANRKLWKSADEPQTFHYLEASNNVPLTSAFKPQVKVLSRKPTVAKDPVVGLGPRLSSSAAADDDDDDDDTKTTPLNPEQIRAKQKRDREEKQKRYDEARAKIFGDSAPSSRGTSPVTVTPPRSADGRHHQHLHHLHHHYAGQGRSRGRGGGQRANADVRQQQQQQQQPPEMRRQNSQARELYDPNCSSKPDAPQPRKGPDGDIGKGPSLRDELLQPIRAPRGPDSSGRGGFGFARRGSKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LL94</accession>
    <name>A0A367LL94_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LL94"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="292" mass="30104" checksum="6AD8985482F4A9F7" modified="2018-11-07" version="1">MNSPRAVGSAKVELQSRVHADDATNQVPIAVGTDPVGHDDARPGRADLELLGALALLAVLDAEVFERGRVDLCRDPLGPARGVEEVAGAEEVDEEGRHGRVGSVGGHAGQGKHLLGGPLELAAAKGDLLLDVLALGNLVKVLYAETAVAAVAVLAVVGPLLGVDGPAATVPAGCSHVVVQCEAADDDDLAAGLAQSRNRRLRPPQVAGLVYVGVLEVLCHLAVCGLSRPLALDAEEDGLGRVLVEEAVCVLEEIVEVLASRQGDGEDAVDERQRRFRRVGGDADVEEADAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMA0</accession>
    <name>A0A367LMA0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mucin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3499</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMA0"/>
    <dbReference type="OrthoDB" id="5380370at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="55817" checksum="BFE1F9E235912776" modified="2018-11-07" version="1">MALDVAEPPACRHSHRRLRSGSGSIRRLRNLLASDVGGQTQDPPPHRLRSRCCRLLDDCLWPHHRPSSSPVRRPPPISSDGSVNKTMTKPKYISTLEHLGFVDGSGLSQHKRSASLPTSSLEQNCVQSPRRRLKVGVASRSGLGFRRDEPTRRRVIREAADETGHKSGKRHFEVASPSPPRLDRPATVEMQTAADQKPDLAGTAESMYDSFRWLEEDDDLDLRLFLDDYHLNLREEVLAPTKSQSGRPSFRRHLSISKLPFGGRVSGTFSRPSTKDEGSPISPTSPVFGNSGHVRRRSRALSLMAPRQASPDFSTTIDAAASHYQDPEARMKLRVYLASPHKFDEAIEFGFPSIEEVHDQEAQEPCKDKSTGSRHTFLEDDGSSVYSEESMADPESPKTPGAADKALPMRPVRVSQDTGSGSKLDYASSREMTLRMTLTRPDLRSHEEQMYGWQKSSAGRRSHEPLPKGSIEQQLAAIDQEELAGDGSAVKRFWNRVRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMA8</accession>
    <name>A0A367LMA8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_3392</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMA8"/>
    <dbReference type="STRING" id="1330021.A0A367LMA8"/>
    <dbReference type="OrthoDB" id="29523at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="29"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI15541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="347" mass="39843" checksum="C582B301DA73E1B7" modified="2018-11-07" version="1">MGILAQRKSRNSRRTISRDPNNSKWMRDTSNYGQKIMRAQGWESGQLLGAQNMATSKLHSQASAACIRVTLKDDLRGLGYNQATKDRVTGLDVFSDVLSRLNGKSEEDVAKKKQERLVLQSNMYLQQKWGVMRFVRGGVLVGDAPEEEGEEEKDDTTQEERREKSEAVEKVKKSKKRKLGDDADSREEKKKRRKEEKRRAAQDGQESNEDKEMMRPGREGCDQSAETEVTMEERRRTKSKSKDKARRSDDKGESKKMKKKKKKKKKQEEEEEEEKQKGRRKDEAEAEVEVEAETGTESEAPRAMAAETTSVTMMRGHRNFARSRFIAAKRQAMMDAQALNQILMIKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LME8</accession>
    <name>A0A367LME8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="10">dUTPase</shortName>
            <ecNumber evidence="10">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_3436</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="2">This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>dUTP + H2O = dUMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the dUTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="10"/>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LME8"/>
    <dbReference type="STRING" id="1330021.A0A367LME8"/>
    <dbReference type="OrthoDB" id="419889at2759"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.40.10:FF:000004">
        <property type="entry name" value="Deoxyuridine triphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00576">
        <property type="entry name" value="dut"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001862">
        <property type="entry name" value="PRK00601.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241:SF0">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="dUTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase-like" evidence="12">
        <location>
            <begin position="43"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI15613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="173" mass="18243" checksum="A23A5C33F1F7E77E" modified="2018-11-07" version="1">MTSTTTPANPSPPAKRIKMTDESTTPATVESVPALQVKKLSDKARLPTRGSAFAAGYDLYAARETVIPARGKALVDTDISIAVPAGTYGRVAPRSGLASKNFIDTGAGVIDADYRGPVKVLLFNHADADYDVKEGDRVAQLVLERIVTPDVVEVQKLEESVRGAGGFGSTGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMR5</accession>
    <name>A0A367LMR5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMR5"/>
    <dbReference type="STRING" id="1330021.A0A367LMR5"/>
    <dbReference type="OrthoDB" id="1022638at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="31278" checksum="223471ADE5F63048" modified="2018-11-07" version="1">MTTASKDARLLHRCLTNKSLPPIPRPAPPPTTTTTTTTTTVLVGSEKTRFKLDRDRLCAVSAFFHDRLGAGDGQLWLPAESAAAFGLLAQWLHESSSLDGVVALARARGSKAARELHWPLVSLHLLASRLHVHQLQDHAMDLLQDLYLACNWHVAPSLVAYLYTKCDVIPAVRIRRWVVAMVAAASDDEDDVGDETRTKFGSLPDFVDDYHLHLAGLARAGLDVRLKDPRRRIACNRLRNHGRRFAFRQCSFHVHRAAVGEGPCPHARGHDSCSADEDGKPVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMW7</accession>
    <name>A0A367LMW7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="4 10">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_2052</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="4 10"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMW7"/>
    <dbReference type="STRING" id="1330021.A0A367LMW7"/>
    <dbReference type="OrthoDB" id="4187847at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000006">
        <property type="entry name" value="Mannan endo-1,6-alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF41">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR016302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI15758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="493" mass="53603" checksum="2ADC6076D6284D42" modified="2018-11-07" version="1">MLQNQPHCFPRHFLFSYSLFFINATNASELTMRGLAAVLAVTLGLLSQNVRGIELNVDDDASLKQAAGTAAFGLMKYYTGNNTGDTPGNLPAPYFWWLAGAMFGTMVDYWHLTGDSTYNEVTMQAIVHQASDTKDFMPKNQTRTEGNDDQGFWAMTAMAAAENKFPDPPRDQPQYLALAQAVFNQYAGRWDVDDCNGGLRWQIFSFNNGFNYKNSISNGCFFNIAARLARYTGNTTYADWANKVFEWEQQVGLIGPKMEVFDGITIGSDKQCHNLNTMRWSYNAGIYLEGAAVMFDVTKNDTWKQRRDGLLQQSLETFSKDQVLFEQLCEPSKGCNNDQQSFKGYLARWLAGTVRVAPETADTIMPVLRASAKSAAESCTGSPPPGAPPVGFAGLPGTACGFSWQQKGFDGISGVPPQMNAVSAMIYPLAQKASAPATEKSGGTSKGDPKAGAGEVKDPTALRPITAGDRVGAGFLTLFMVAGSLGLSTFLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LND1</accession>
    <name>A0A367LND1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1959</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LND1"/>
    <dbReference type="OrthoDB" id="4923704at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016670101" evidence="1">
        <location>
            <begin position="19"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="222" mass="24362" checksum="90DDAC00C75AB35A" modified="2018-11-07" version="1">MLTHILLLSLLHPPPALSGEAAAQQPTSFTTCSDKACYKELSKASGNNPTSLASFCSDSYVTDSSHAERYNLTVDFAPGPDCNDIKLMDTIRPLCDCVANEVNATWNGQEAVKEKEEDDEAPELDPNLNMADFLFEDCRKFPCYSYLDIIFDTPGELKSYCRDPSSSQAPGLDQNSLEEHQCRDLKPACDCIGKASASPSASLKKLCIFFSFSFLKDKVNAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LND9</accession>
    <name>A0A367LND9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein uS7m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_2731</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LND9"/>
    <dbReference type="STRING" id="1330021.A0A367LND9"/>
    <dbReference type="OrthoDB" id="9972728at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.455.10:FF:000006">
        <property type="entry name" value="37S ribosomal protein S7, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="9">
        <location>
            <begin position="176"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="38"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="124"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI15956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="348" mass="38439" checksum="E4547534EBF4A45C" modified="2018-11-07" version="1">MSPGLRIWAAGRAFALHARPAVVLPKIQVFRQVRDARRSYSDHRSNKPATSAAQAGGPGQEPQANNIPPMADAAGQAADDAPRSFIDTLDDATLGMYESKPLTPAQQDVLYTQGRIPNPDEAETILSDQVDAEEAVADTEPELEREPEPKPKPEDPGHKYGLPEKPYPPNFHLKKRYHPVLDQITRLLMRDGKLSVAQRNISMVMNFLRTSPPPIYSPKFPLLPGTPPAWHLPLNPILYITIAIDSVAPLIQISKLAGAAGGGRALEIPRPLAVRQRRRIAFKWILDVIESKHSRGSGRKQFPSRIADEIIAVVEGRSSVWEKRKAIHKLGTASRSNVGTRRRGKPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNH0</accession>
    <name>A0A367LNH0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNH0"/>
    <dbReference type="OrthoDB" id="5366332at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="157" mass="17606" checksum="16B3B6012C80F8FB" modified="2018-11-07" version="1">MLSHEQGYHNIDPIPSSTCQTPTSTIVLLARNDMQTGETASTPLPPQTTHYWTSDRTRRLEYAAIDSAPRGLRGWLRRRLGFRPRHISFDDDSGSVRRYRLHLSDDDDDDDDDEGGGGGGEGLSSPSSSSSSSSSSSVEKRRPSWQFWRHLRKTKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNZ7</accession>
    <name>A0A367LNZ7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_3083</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNZ7"/>
    <dbReference type="OrthoDB" id="5299893at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071986">
        <property type="term" value="C:Ragulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043410">
        <property type="term" value="P:positive regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032008">
        <property type="term" value="P:positive regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001919">
        <property type="term" value="P:regulation of receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028209">
        <property type="entry name" value="LAMTOR1/MEH1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01262">
        <property type="entry name" value="LAMTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="4" id="KW-0564">Palmitate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI16129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="168" mass="17830" checksum="D16A5D640C5CD408" modified="2018-11-07" version="1">MGACSSCLGRPGREGHDETEESRLLYDDGGGLQYGSFGDGVMGGDDTIEAQREMEALQRVVAKTSSNMVDVFESAPMSRNGASISFAFAGQGVRTARYQHLVSKLGTDDEEADVRIDWLIDDEDDGREKRDKDGANVPVKGTVKTFDGDEAGGPLVGTFADAAAAAMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPF4</accession>
    <name>A0A367LPF4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPF4"/>
    <dbReference type="STRING" id="1330021.A0A367LPF4"/>
    <dbReference type="OrthoDB" id="5429993at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="470" mass="51477" checksum="87357F266D687D05" modified="2018-11-07" version="1">MSSLQRTRSHRKAPPSLPVEPSSSHSHSRLPVKPALTTTTTTTTTTNGSRPRPVSAVIDRRPTTSTSTSGTSTTRFRSGGARPLSAVLDHRSSSSAPRSQGAGSLGRSSSTRVPSSSVAVAEQRRVPAVHARAKSVATAGLAVHSLAETKASTTSSSISWQQQQQQQQQQQQQQQQQQRTRPAFSTLQQHYTPAKKATSKPLTSTFLAPPSPSKLPANVAASAQAQRLQTELLQLHLLHRDAINVTDQWHDSAREKLGRRFGALGKASGVVAQREAVVDRRRNLDALGRWRDDGCLEERLQSLGHVLDGLWTLTGSSGGRFRRMERDFDRWADGLRRIEAARANDDDDDDDGNDDDDGNALVGFLDEELDSSWKDDCAVLTSRLLAWQSQLSMLMEDESFLADDDDARPTSGLERMVMGAESLLRLMLAELRAMEDIEREARAREVDLEGCIGGVGKLGTCMDQPMQERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPY7</accession>
    <name>A0A367LPY7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_2864</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPY7"/>
    <dbReference type="STRING" id="1330021.A0A367LPY7"/>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45782:SF4">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI16496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="421" mass="47413" checksum="975BD51BB2076191" modified="2018-11-07" version="1">MVAASSSFAFVARESFHVPSIVPKTYFSGHHKVAMEKIKKLLPSISLVLECRDARIPLSTQNPHLERLVAGRRRLIIYTKSDLASESNRRPVLRQLNGDTAGQKTVFFWSHKDHSRCQPIVRRIRELSLQHDQESPLGMRTLIVGMPNVGKSSLLNDLRISGDSHIKNCQKRFAISSGNLKICAEIKRYKIAKTKFFQMKTKQIRKEKEKEAKLAEKNQNRIITAEDFITNPQKKKKVAKTGDQAGVTRKVGPAVRIWDDTRGYIDGGKAVGSRAAFMMDTPGIFMPYVQDGETMLKIALTNGIKTGCIDDMILVDYLLYHMNKVNPSIYSRYCKPTNDVEEFVGAVARIEGRFLPGGKPNLNDAAARILSRWREGRLGKFVLDDLSPEGVHQHKLQLLSPDQSMNQAKMMAKIRREAVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQK3</accession>
    <name>A0A367LQK3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_2416</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQK3"/>
    <dbReference type="STRING" id="1330021.A0A367LQK3"/>
    <dbReference type="OrthoDB" id="271595at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106335">
        <property type="term" value="F:tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051422">
        <property type="entry name" value="AlkB_tRNA_MeTrf/Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13069">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13069:SF21">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="3">
        <location>
            <begin position="58"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI16512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="226" mass="25157" checksum="842E29AF1D99BA00" modified="2018-11-07" version="1">MSGKPDQQSSVIDDEAYEDIHVHEVYEAIAEHFSSTRHKPWPRVARFLQGQRPGSVGVDIGCGNGKYQPVNETVVLLGCDACASLVRLARLERGAEVVTADGLALPYRTCRADFAICIAVVHHFSTRERRRAAIGEVLSCLRAGDESSRALLYVWALEQSSSRRGWDVGSDPDALVPWVARGTTYQRYYHLYAQGELDQDVVAAGGEVVESGYERDNWWVVCRRVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQN6</accession>
    <name>A0A367LQN6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQN6"/>
    <dbReference type="STRING" id="1330021.A0A367LQN6"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050982">
        <property type="entry name" value="Auxin_biosynth/cation_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43539:SF68">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-LIKE PROTEIN (AFU_ORTHOLOGUE AFUA_4G09220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13738">
        <property type="entry name" value="Pyr_redox_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="622" mass="69505" checksum="AFDA6107D532FAF9" modified="2018-11-07" version="1">MAEPPAFSLPLAVFPSASPPPETVRPEHEAEALLKTLNRALSQADYRAAANLFTDQGFWRDHLALSWRFRTLKGRDGICKFLEECAKSRDGFRIKSFSLDSGSPSRKPHVAPVDAVGKVVGIHAFFLFETAIGSGEGLMRLLLQHGQWAIFTFYTSLRELRGHEELTFDRRPVGVDHGEHLCRKNWSEKRRLEGEVGQDNNLSVLIVGAGQGGLTAAARLKMLGLDALIIDQNDRVGDNWRKRYHHLVLHDAVWYDHMPYIPFPPNWPIFTPKDKLAQFFEAYAMLLELNVWMKTTVKSCKWDEHRKRWSVTVSRVMDDGSTQARTLHPRHIIQATGHSGLKYQPEIKGSDSFKGDVFCHSSEFAGARKGTSGKRAVVVGCCNSGHDIAQDYFENGYDVTMIQRSGTIVVSSSSVTDVILNPLFTEGGPPVEDGDLNLHGTPISVFKAIQKEKTQICRRNDLETLTALDRAGFKLSYGPQDTGFYMAYLESGGGYYIDVGASKLISDGKIKIKQGHEVAEILPHGVRLADGSELEADEIILATGYQNMKSHTKQIFGSHVSDRVNDVWGVNSEGEMRTIWQDSGHPGFWFHGSNLGMCRYFSRLLALQIKGLEEGLYKYGDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRE6</accession>
    <name>A0A367LRE6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_3092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRE6"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI17024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="125" mass="13976" checksum="6AC82434D74B5B44" modified="2018-11-07" version="1">MGLRAQSPLNPMGIVIAARELGKSDFLSVGHNFSIRKNVGKKWVFCGAVEEEEGGKKLVESVKVSRESRNGLKEAIEEELEAGEVFVLRRSVIWRKTCTCQSDRSDRSDPMIPAMTAMTRPLWPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRQ1</accession>
    <name>A0A367LRQ1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein AF-9 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_2184</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRQ1"/>
    <dbReference type="STRING" id="1330021.A0A367LRQ1"/>
    <dbReference type="OrthoDB" id="16041at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16908">
        <property type="entry name" value="YEATS_Yaf9_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="entry name" value="YEATS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005033">
        <property type="entry name" value="YEATS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055129">
        <property type="entry name" value="YEATS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47573">
        <property type="entry name" value="PROTEIN AF-9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47573:SF1">
        <property type="entry name" value="PROTEIN AF-9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03366">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="YEATS" evidence="7">
        <location>
            <begin position="63"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="234"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="283"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI16912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="337" mass="37840" checksum="C5F4268CE2D6E3D4" modified="2018-11-07" version="1">MKSSTVKVAQGVTWKTSASETSNHVKDNAWKKLLLQPRPQLISLFLLPPWAIKMAPTNHLGKRVKLTQIRRPFIVGSTALPFSDSNPKPAGTPDNHTHSWQVFVKGLDDVDITYWLRRVQFKLHESIPNYVRMIDGVPGKPFVVQDTGWGEFDITIKLYYVNESGEKPQTLYHYLRLHPYGRTEEEKQAMMTQNGQVRAWTYEEQLFNEPYEAFYQLLTAGAVPRGWKLSSSAITPGTSVSAGGKGKGKGKAPPPLPDPESGEVWERTAMIPTYNRPGQPFSRETEAAENKKLKEAQEKTEELTHKLMADIKTREQLLASLKAENQSAVAVASSQPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRU1</accession>
    <name>A0A367LRU1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_3116</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRU1"/>
    <dbReference type="STRING" id="1330021.A0A367LRU1"/>
    <dbReference type="OrthoDB" id="425534at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF30">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="101"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="4">
        <location>
            <begin position="410"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI17166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="507" mass="54778" checksum="F7FC3AA07D5B6F4E" modified="2018-11-07" version="1">MPITRMDQKIAFPGPAPRRATSGTWTVRFIVTLAAVAGIKCFAAGQKTISWGDCPSDYPPYLDCGRLSVPLDHKCSRPGCRQIELGMVRSKAKASKPLGNLVLNPGGPGSSLVGIFVRGRQDEVVGPKLLHSYNVIAPDPRGVGISTPVRCSAGLYNRRTPLYMTGQADLEARIAWNKAFGESCVRMTGPVIKHVDTVSAAKDLEHIRKALGDEKLNFMGFSYGTQLGSQYAELFPHRVGKMVLDGVLDHSQLDVDGLMTEAISYDDSLKGFFAWCNTTTSCALHGQDASAIFDKLVDEANMEPVPAPGCGGKCAPDVTGYELIMNAQNDVSEPPRWQRLSHSLREALEGNATRLSTQLVRNETSSAFSHTAISCLDSAASTAGGSSLLGRLMAARVLAPHTRGVSETLQIQASCLGWPALAANPPRKLSRDRLARTPPILLVNAFHDPSTSVVWALGVREQMPTAVSIFRDGYGHTSYWDYGETQEAIDSFLIDGRMPADLTVFKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRZ0</accession>
    <name>A0A367LRZ0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_2819</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRZ0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI17157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="59" mass="6177" checksum="BBEC17B66A9A8E1E" modified="2018-11-07" version="1" fragment="single">ILVLLNPAPLARPGVSVAINATKSVTSNENGPCDRATKRALEVWLVDAARGPSKATPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LSG2</accession>
    <name>A0A367LSG2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_2099</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LSG2"/>
    <dbReference type="STRING" id="1330021.A0A367LSG2"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17982">
        <property type="entry name" value="DEXHc_DHX37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000637">
        <property type="entry name" value="ATP-dependent RNA helicase DHX37/DHR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF99">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="383"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="582"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="99"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="194"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="652"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="108"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="259"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI17395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1216" mass="134385" checksum="8F14364785EDA8A5" modified="2018-11-07" version="1">MAKFVPRQRKHKVLAREKAKANARHDVQDTNQEMLPADKKAQREKKDGAKAAALNEGVKMSGKKAKRFEKYINNKLRKDENRDLLAKLAARKIDTSLFASSKSLGQGRETKKQALSRALREQRAGIHSEQAENFLLEKRRLVDQAEAEDNDEPESAEEEDAELVPTKLSGSGIHVLPPPAEPVIDASALVGSGLKRPLEIDDQGRPIIRKRQKRGGVATKVQLADTTSTTSDEAEYDEWHGFNSDAEPSNSADDHISSEEGESSETDDMEDTGEDMSDNDSMDEGDEGEQHRAQRSSAFKAWAHQQRNEALGFQPAGTSATPLAIPRPDNFVPRAPEQDPLPAELQPTAETERKAFSVEVVRSPEVQAARLKLPIVSEEQRLMEAIHNNDVVVICGSTGSGKTTQVPQFLFEAGYGSPDSPTPGLIGVTQPRRVAAVSMSRRVAEELGNNADAVAYQIRFEGSVDAKTAIKLMTDGVLLREVAQDIALRKYSAIIIDEAHERSVNTDILIGMLSRVVKLRAEMAREDASLKPLKFIIMSATLRIEDLTLNRTLFATPPPVLEIEGRQHPVTIHFSRKTRHDYVEEAFRKISRGHRKLPPGGFLVFLTGRNEITQLSKRLKASFAGYGTAEGPSVQISANEAPVEVEDIEFGDVDGDAEGETDDLLSDEEDEEDDKEFEVNEENQQMGPSKMQILPLYSLLPTREQLRVFEPPPDGTRQVILATNVAETSLTIPGIRFVFDCGRCKERRYDRLSGVQSYHIGWISKASANQRSGRAGRTGPGHCYRLYSSAVYERDFAEFADPELLRMPIEGVVLQLKAMNLQHVVNFPFPTPPERQSLAKAEKLLAYLAALSPDGQVTQVGRTMSVFPLAPRFARILLVGHLHDCLPYTIALVAGLSAAGEVFVPESQAVPALTVREEATFRTNADVMAEDRQANARRMFNEVHRNFCFLDERSDAIKLLQVVGEFAHEPTEQWCDSHFVRFKVLKEIAQLRRQLTELLSLNIPSLSGLGLQEKLPPPSAKQVSALKQMAAAGFVDQVAIRADLAPNPPEQQQQQRRKPRRAIDVPYMPLTPTATTGGGRAAGGDVGLAYVHPASPLAHLSTGEMPEYIVYTYLQRSEEEGAKTRMHALTDISGSQLAALAKGTPLLCYGKPIKEIKADVDERECWVVPYLRPEGLGGGMGWPLPPKKVVQKRVPGKVGKDEYPELLTLPDILMQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LT25</accession>
    <name>A0A367LT25_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2268</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LT25"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI17362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="180" mass="20708" checksum="617B20EEA6E59B18" modified="2018-11-07" version="1">MKEMKEKKEKKEKKEKKEKKEKKEKKEKKEKKEKKKEKKEKKKKNGRVEYVCRARRGKINHPPPPFLYDDGSCLLGARPPVIMISTNAVLCTMESCNHARRAHGIKAYRPQAQGGLAEAFWRRMYICINSFRFKGYSGGKTGSSLPNQVPLFWGKGKGKITDGETWAGRMIMGGWDDSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZ36</accession>
    <name>A0A367KZ36_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_4546</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000028">
        <property type="protein sequence ID" value="RCI07439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZ36"/>
    <dbReference type="STRING" id="1330021.A0A367KZ36"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI07439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="579" mass="64588" checksum="5F92A6C97A19CBCA" modified="2018-11-07" version="1">MILDGSHFDFIVVGGGTAGNTVAGRLAEEPKARILVIEAGVGDPEHVPEIMTPSEAMDLRDSPYDWSYKTTMVRRDDYERIEKPNTRGKVLGGSSSLNYFTWVPGCKATFDRWAEYGGEDWSWEPLLPYLRKSATYHDDDGSYDPDLAKIGKGGPLPIAHSDLIPAMKPFRDAVIRAWKSRGEPMTDNVYDGEINGLTHCVDTIYRGKRSGSFLFLRGKPNIVILAEAHSKKLLIDDGICKGVVVVDRHGRERRLFADREVILSQGVFESPKLLMLSGIGPEKELSRHGIDTVVESPHVGRNLFDHPAVPFVLRVEDQYGMEDVLLRKGHQHEAATAEYGRNRSGPVGSGLLELVGFPRIDGYLENDVAYRRAKEANGGRDPFSPEGQPHFELDFVCMFGSAFQWHYPVPSHGSYTTVVVDLVRPVSEPGEVTLRSADPLAPPYINLNFFADDLDIIAMREGIRFTYDMLTKGDGFKDIVLGQYPWDMPLDSDKAMKKAILDRCQTAFHPCGTARLSKHIDQGVVDGRLRVHGVKKLRVIDASIVPVIPDCRIQNSVYMIGEKGADMIKEDHDDLYRCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZA4</accession>
    <name>A0A367KZA4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8331</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000027">
        <property type="protein sequence ID" value="RCI07509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZA4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI07509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="165" mass="19010" checksum="AE923DFD8A2426AF" modified="2018-11-07" version="1" fragment="single">MNLLRVCHGTDLGDSESPKYASPSLPPSPLLLNYSNRVLFSVKQKQNKLAVKISVCFANEEESSCHSSLHSRYSSYSSPGRTVELRQQGEGLLCHIVPEQEEGGGGKKRRNREKSRKRRKKRKRKKRRNRKKREGGRICYQQKTVKDSQRLYVNHLIRLYAAQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZD8</accession>
    <name>A0A367KZD8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_1661</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000026">
        <property type="protein sequence ID" value="RCI07543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZD8"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI07543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="233" mass="26289" checksum="129A79E0A79CD6B4" modified="2018-11-07" version="1" fragment="single">PPQRPESQWGYSGHSARIDSLQRSSQRSARCTYSGHSTRLISAQGSRHIDRRAVLIAVIALDQSSQRDRHSDRRAVPIAVIAPDLDGRTKVRSTFRSTFVVEKFVYKGRRFSHLLPVYYQLQLHYFFNTITSPAFNSSSILTKPLSRYKPGFSHLIRDTNKLSTNFSPPSSSSTAPQNTSFDSTFPTLFSKHTHFFPIFFLIEKSCPTLRKSLLPSSRAAITIPIGLCAWIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L087</accession>
    <name>A0A367L087_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_5831</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000023">
        <property type="protein sequence ID" value="RCI07821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L087"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI07821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="179" mass="19500" checksum="5DAF746CEAC05201" modified="2018-11-07" version="1">MSKEREKKSESAALRARVCDEEEDDDDDDTDEGQAMWLWAGFCQARRRWGMWYVQTGWSGSPGGAARSNAKATKSDLTQRDARTGGRVRGGRGGSKQASRRRRRRRQQQQGLSVGGGWWVVVVVVVVVVLKLGGGDGTEREGGSGLGVYAANGQKKKKKGARTRRGRGRGEAGSEQMDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L091</accession>
    <name>A0A367L091_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Superoxide dismutase 1 copper chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_1611</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CCS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000026">
        <property type="protein sequence ID" value="RCI07632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L091"/>
    <dbReference type="STRING" id="1330021.A0A367L091"/>
    <dbReference type="OrthoDB" id="666972at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006801">
        <property type="term" value="P:superoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000038">
        <property type="entry name" value="Superoxide dismutase 1 copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMA" evidence="9">
        <location>
            <begin position="6"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI07632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="242" mass="25930" checksum="9C32047A1FFBDE0A" modified="2018-11-07" version="1">MTLNTSFQTVFAVPLSCDDCIKAVSDQLYGLDGITEVRGNLRDQLISVQGSAAPSAIVEAIRATGRDAILRGSGASDSAAVSILETFAGRSGDQDRFPDRAVRGLARMVQISPERTLVDLTVRGLAPGKYRATIREYGDLKDGASSTGPLWSKGALGVLEVSEDGRGSAFLDPPFHIWEVIGHAMVLTKQDESTQPLQNDEDTVVGVIARSAGAWDNDKTVCSCTGKTLWDEREDEVKKGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0C8</accession>
    <name>A0A367L0C8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5802</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000023">
        <property type="protein sequence ID" value="RCI07857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0C8"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI07857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="102" mass="11140" checksum="8768F6C9555C2288" modified="2018-11-07" version="1">MSTSKLCGGGLKTATWVVPSYAASSDSGLRTGCVLQPPVSHLALEMGQVRAGGAGSHFSPHIHYRWYRYEIDGRLWRQAWPQTEMVLCTRNSPAQECLCASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L173</accession>
    <name>A0A367L173_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Bicarbonate transporter-like transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_6268</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the anion exchanger (TC 2.A.31) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L173"/>
    <dbReference type="STRING" id="1330021.A0A367L173"/>
    <dbReference type="OrthoDB" id="1735926at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080139">
        <property type="term" value="F:borate efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050801">
        <property type="term" value="P:monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.570:FF:000003">
        <property type="entry name" value="Anion exchange family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.570">
        <property type="entry name" value="Helical hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF82">
        <property type="entry name" value="BORON TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="235"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="465"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="9">
        <location>
            <begin position="27"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="9">
        <location>
            <begin position="198"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="544"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="544"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI08175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="622" mass="67786" checksum="68A4A437F24B6327" modified="2018-11-07" version="1">MDKTVDTTTAAEPAPRDDGEAWWRLHLFRGISKDIRRRAPFYPSDWRDAWDYRVVPATIYMYFANILPALAFSLDMFQKTGSNYGVNEVLLASVLASVVFSLFAAQPIVIVGVTGPITVFNYTVYDIMMPSGVNYIGFMAWIGIWSLILHWILAITNSCDWLRWVTRFPCDIFGFYVAFIYLQKGIQVLARLGDGTAFYLSIVAALLVFMSAYICGQLGTSSLFTHPVRVFLKDYGTPLTLIFFTGFVHFGRMELVNIERLPTGIAFEPTSGRRWLVDFWTLSVGQVFTALPFAVLLTILFWFDHNVSSLIAQGSEFPLRKPAGFHWDLFLLGVTTGVAGILGLPFPNGLIPQAPFHTESLCVTKLVRKLDAQGEDKGDYAFEPTHVVEQRVSNLAQGLLTLGTMTGPLLVVIHLIPHGVLAGLFFVMGVQALEANGITAKILFLCRDKSLTPADNPLKTIKRRAAVWLFVAIELVGFGATFAVTQTVAAVGFPVFIIALIPVRAKLLPLVFQPEELAVLDAPTASEFIMEGIGGGGTGTACTGIGTGTGTGTGTGTGTDSSQTAAGGPSRSRSRSRSLSISRDCVRQASAASGRKTVEHLAELGQAQSVQSSATRRRGDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1H6</accession>
    <name>A0A367L1H6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_8354</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000020">
        <property type="protein sequence ID" value="RCI08268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1H6"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI08268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="43" mass="4895" checksum="8C10985FA65B5CA3" modified="2018-11-07" version="1" fragment="single">GKVGKEEGGKKEVKIDKKLTNREEEIEEELEAGEVFVLRSSYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L215</accession>
    <name>A0A367L215_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ring-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_8935</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L215"/>
    <dbReference type="OrthoDB" id="5398191at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI08454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="380" mass="41243" checksum="29F86D9F5FD1762A" modified="2018-11-07" version="1">MLEYLTYKKVKKHRAEKKAEESAKRVAELTSVDDDAVLLRPDDESFLKNLLARDDGTKSSPPIQTEASAAQLDWPSSDNEAAPSKAAEAGQSSSSVDQGSSSSSISAPKTPGRLSVFFTRYRKTESGLQPPPAGVVSADETERETRDLSRVLDRLNLSARNNKVVTTDASTLLQGFTQVFKDLVNGVPTAVDDLTKLVEDRDGTIARGFDKLPASLKKLVVQLPDKITNSLGPEILAAAAASQGIKTDAGGGIKGVARKVLVPHNLAELVTKPGAIVGMLRAIVEVLKTRWPAFIGMNVIWSVALTLLLFVLWYCHKRGREERLERERSAMAVDGADRIEELADDPALPPPESVEDDVPHSASSPQPLRRRPLPVDRRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2E4</accession>
    <name>A0A367L2E4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8035 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_4739</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2E4"/>
    <dbReference type="STRING" id="1330021.A0A367L2E4"/>
    <dbReference type="OrthoDB" id="5418088at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058348">
        <property type="entry name" value="DUF8035"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42081:SF2">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42081">
        <property type="entry name" value="ZINC FINGER PROTEIN DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26118">
        <property type="entry name" value="DUF8035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8035" evidence="2">
        <location>
            <begin position="691"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="614"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="625"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="644"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="675"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI08601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="745" mass="82495" checksum="CFFEAF580E02E799" modified="2018-11-07" version="1">MSDRHRSVNPNRASMPVGSGYGSLYAGSEPPRPYVTTPRTYVTSTSAAGVPTTTRTYAVGPDRRQHSAARRSTLDCGAVRPVIVTTCAASPSTASASAAPHKDRSHTSSSANRAASPVRHDEHRLYAQPASSIRSHSTTRPYYVSAADDVGRFRDAMLSPREVDAYRSSRPSVVYPSDPRHSNAAVDYADDGYQYTNAGELVRYDLGVADRASRPRRQESVDRGYHRHYGPDKRGFNYNMNTSRPYDSRTGPPPSTRRFGKITRAFEPSRDPPPAAPIPPSPTVATQSEATSDRWDATGRRGGSNRPHSVQQEGAPIRSSHHDDRHRSRDDDRHRSRDDPNRGLDLPRFKDDNVSSRGFGIRTDVAGRRDSRIEDDFMPVEDRHERRHDVDAGADRERSRLRDKVAAGLSVAATAVGLASPIVKDDGAREPGLREPRRRRSPDEGRDRWNDAADTPLSGTEREPGRAGGSSSLRDEPRLHPGASDRLRRESETAADRVRRDADAVAATISHRRDPDVADRHRRDPEVADRHRRDPEATALVEAVASPSDSEDGRRAPRRHRASAVFNPNDASDLRQLKEELAARDVSDKGNEDKQQVVSEERQASRSPSPTKRRGSDDSSRSRELALTTAPAATTKQVRVVSPPRDKAEERPLKGILKQPRASFPEDTNPIREGVAPHKEDKKLKEAPPGARWTKIDSKLVSPEALRVGTERFEVRDDFVIVLRVLSKEEIQTYAAATLALRGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2J0</accession>
    <name>A0A367L2J0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial large ribosomal subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_4794</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2J0"/>
    <dbReference type="STRING" id="1330021.A0A367L2J0"/>
    <dbReference type="OrthoDB" id="416470at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.10:FF:000017">
        <property type="entry name" value="54S ribosomal protein L22, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047867">
        <property type="entry name" value="Ribosomal_uL22_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="CHLOROPLAST 50S RIBOSOMAL PROTEIN L22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501:SF10">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL22M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="50"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI08650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="38786" checksum="CD218302B31DD20B" modified="2018-11-07" version="1">MSFRQAARRLAPLSAPSPTPCSRPAKVRHAGATIAQRRNKWSLDKLRSWALGRPGKPDQGGDLKEQVGLELEDPEKRAEFRRRQLQRTSEGSIFEDDAEKRKKLARELPSSAAGETAVPKTQEVLAMATDPNPRGRVRWHRKKVIQMVRSNDHITRKQKIKMTERELLHKSAFLPTSVKKLVMLSRQIAGKTIDDAIVQMRWSKKKMSREMLYYLEEARDLAVAQRGMGLGKVKGEVLEKPRKVTDKDGKWIEVTDPTRIYIAQSWVGRGTPIATSIDYKARGRGCALVHPKTSFSVLLKEEKTRIRQHEEQKAREAAKGPWVHLPNRPLHGQRPYYTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2Y9</accession>
    <name>A0A367L2Y9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4657</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2Y9"/>
    <dbReference type="STRING" id="1330021.A0A367L2Y9"/>
    <dbReference type="OrthoDB" id="9997739at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF3">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="265" mass="30395" checksum="CD38FF9BDA35D334" modified="2018-11-07" version="1">MFTFAVGPNEREFVVHADLFAKQSPVLSSLMNGSFREAEDAKAFWCDTDEETFIRFCQYTYTGDYDEAPVTIDDVNYADQNVAADHDEPDVGNRCNVVQPLVRAPEAVSRPGEYPMSNNLWQAFCFLRGLDFINDFPLVPDRFFSSYKPRVNKGRAENYTDVFLAHARLYIFSDRYGLERLAQIALLKLHKILIKFRLFKERAGDLVPLVELVYCNPVPQVIRHLVGLYAACKIRKLWRSDDFRELVGGCSELSMSLLGFIVTYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L397</accession>
    <name>A0A367L397_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_4853</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L397"/>
    <dbReference type="STRING" id="1330021.A0A367L397"/>
    <dbReference type="OrthoDB" id="6512918at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00267">
        <property type="entry name" value="ABC_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001332">
        <property type="entry name" value="Similar to ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43158">
        <property type="entry name" value="SKFA PEPTIDE EXPORT ATP-BINDING PROTEIN SKFE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43158:SF2">
        <property type="entry name" value="SKFA PEPTIDE EXPORT ATP-BINDING PROTEIN SKFE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="13"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="256"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI08682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="291" mass="32184" checksum="E199CFAADFBEF730" modified="2018-11-07" version="1">MPSQQPPVGPPRILTKNLTYTFASHASGIRDITLDLPPRSRTLLIGANGSGKTTLLRLLAGQRLAPAGSVSVCGLDPFALPLEGVTYLGLEWVLNPVVRGNDIPVHHLLASVGGDAFPRRRDDLVALLDVDTRWRMHAISDGERRRVQLAMGLLRPWSVLFLDEITVDLDVLARSRFLDWLRRETESRDCSIVYATHILDNLADWPTHLVHMHLGSVKEWGQAEEMLRFVDGPAPSGNSRLGDLALRWLQADIKDRGPRDRTDLGSEGKTYGFGDTNIGGYGYEPPKQSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3L6</accession>
    <name>A0A367L3L6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribonuclease P protein subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_4979</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal RNase P protein component 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI09026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3L6"/>
    <dbReference type="STRING" id="1330021.A0A367L3L6"/>
    <dbReference type="OrthoDB" id="124041at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033204">
        <property type="term" value="F:ribonuclease P RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.210">
        <property type="entry name" value="Ribonuclease P/MRP, subunit p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016848">
        <property type="entry name" value="RNase_P/MRP_Rpp29-subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036980">
        <property type="entry name" value="RNase_P/MRP_Rpp29_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023534">
        <property type="entry name" value="Rof/RNase_P-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002730">
        <property type="entry name" value="Rpp29/RNP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13348:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13348">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01868">
        <property type="entry name" value="RNase_P-MRP_p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027081">
        <property type="entry name" value="RNase_P/MRP_p29_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00538">
        <property type="entry name" value="POP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101744">
        <property type="entry name" value="Rof/RNase P subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="35"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR027081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI09026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="221" mass="24848" checksum="E0B4CC7B4B450E4F" modified="2018-11-07" version="1">MDQAQNAVQSLLARAHSPESAERIFSNKIKHRTLRLRPSSPPPAVRNARTARRIAREKSKKKKGNGGPLSCRERRKLGLDDLSRRGHKYEVYEPLHHLWLGYMRETLGGDLYTGGPAAAAKLASAELHGALVEVVRSKCPSRVGIKGIVVRDRKFVMEVVTEKDRLKMVPKEGTTFRCVVPPEQATEKQSSFAFEILGDQLMIKSADRANRKFKTHFLPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3Z1</accession>
    <name>A0A367L3Z1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_1568</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367L3Z1"/>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14210">
        <property type="entry name" value="PKc_DYRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000112">
        <property type="entry name" value="Putative dual specificity tyrosine-phosphorylation-regulated kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF22">
        <property type="entry name" value="DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="969"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="90"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="336"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="425"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="478"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="564"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="614"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="666"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="740"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1264"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="220"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="243"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="371"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="577"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="624"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="707"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="767"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1302"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1336"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1373"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="998"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI09153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1385" mass="149453" checksum="3BC44970B8C46E32" modified="2018-11-07" version="1">MTLEHKASFAGLRPANSSPARPTSYRSSPSSSSTSEDDVDASMLAAPSSSHHPLPSIPRNGQMAAQVAAPQYELLPSVSFDDLHASIETASTNLKRSHPLPTSTGPPARDSAGMIDRTSTPQRHSVAHGPGQPRSANAPFATRSSRSGSILRGPNAAPKQPTTTSSENHSARSRRQSHYPPISNATVAPKPPRKSVGPAMADVQVRASRARRPSLLADRASGDATRRSVDATRRSVDGFPDGTRNAASSRATKAKSALPPTRSAEAIPSTASVLTSSDDNRLASRSPRVSVRAAAQPPIGKRGSMMPGAHHPTHVTGLGARTISPTDTRRMKRLSTMPQSQSLNAIFKAPPPPPPPSMDLRDYSRSPSMIPRRTTATPSSARTTPDVGNRKSYGSAHSVTSAASFNTLRTSSGSLQPRISLQSVSRLPAPKHSASHNSLSADAEEDVPPVPAIPKAYESPKDSSADVCFADRRKTSLGEPLGGFPGSVGLIPFPTHPEPTKSTPNRSGPTRGPVAPAASADDGNNGGGVQPKKHLQPLRLPPLNLGPLKLPPSVRIPAASNVADLRCDMSPPPSRQLPKTPSTPMTASKTAFFSKKYDDAIQLPCLRSSSTIHNTYRVTPTPPDADSSSSSLAASETNHKASLSPFLSTSLPKGGFEPALLKRSRTGVDSHAVAGNEFDDAPRRKPVAARESGSDKTATPKSPPPLSDSTADEPQTPSSINSLRRKLSLSWMRNGTKSNAAVSIDAADKPATRQQPPKQEAMPTHRIPSSATTGNLSIPKRLNQSPTVGPNGLYVELRRRKDSTASLTGQLAQDRVRSDNWGSKKERSELVASQGIHGTGIMSKMLKPKPSNVGYSAVELDKDDLVAEEEMRKMGSRRKETEVAAKALDALRKRATPKERVSPHEAIRIAMLNIYERGEIVDFDDIYFCGTQNANKVVGDVQSDAPNFGYDDDRGDYTIVPGDHLAYRYEIIDVLGKGSFGQVVRCIDHKQGALVAVKIIRNKKRFHQQALVEVNILQKLREWDPKNKHSMVSFTQHFYFRGHLCISTELLDMNLYEFIKAHAFRGFSLRIIRRFTKQMLSSLILLKQRKVIHCDLKPENILLRHPLHSEIKVIDFGSSCFENEKVYTYIQSRFYRSPEVILGMTYGMPIDMWSVGCILAELYTGVPIFPGENEQEQLSCIMEVFGPPEKHLIEKSTRRKLFFDSVGKPRLTVSSKGRRRRPSSKTLQQVLKCDDEVFVDFLGRCLRWDPERRLKPEDAIRHEFITGQKPAAPASRLPARDSSPVRRSNTVSTPRPLPDPPGGGGRGVGGGRTASSPQKFVPPAAARRISGATGATAASNNRRTSAGSGSISNGVSGLPRAAGRTTSGRTDLAAAGAAAAMTRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4H1</accession>
    <name>A0A367L4H1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">NEDD8-conjugating enzyme UBC12</fullName>
            <ecNumber evidence="11">2.3.2.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">NEDD8-conjugating enzyme Ubc12</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">RUB1-conjugating enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Ubiquitin carrier protein 12</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin-conjugating enzyme E2 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">L249_1556</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.34" evidence="11"/>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4H1"/>
    <dbReference type="STRING" id="1330021.A0A367L4H1"/>
    <dbReference type="OrthoDB" id="10249039at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061654">
        <property type="term" value="F:NEDD8 conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23794">
        <property type="entry name" value="UBCc_UBE2F_UBE2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000005">
        <property type="entry name" value="NEDD8-conjugating enzyme Ubc12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 17" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="19">
        <location>
            <begin position="31"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="16">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RCI09308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="186" mass="21052" checksum="3F8D87061D3E0E2A" modified="2018-11-07" version="1">MLKIWSMKKEQKQAENAEGQAGGGKKKKVTAAQLRVQKDLSELSLGSTMKTDFPDADDILNFVLTIEPDEGMYRGGRFTFDFAINQNFPHEPPKVRCKQVIYHPNIDLEGKVCLNILREDWKPVLNLNAVIVGLQFLFLEPNASDPLNKEAAEDLRFNREAFKRNVRVSMGGGLVKGTTYDRVIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4U6</accession>
    <name>A0A367L4U6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_3717</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000015">
        <property type="protein sequence ID" value="RCI09437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367L4U6"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041068">
        <property type="entry name" value="HTH_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF21">
        <property type="entry name" value="NON-REDUCING POLYKETIDE SYNTHASE AUSA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18558">
        <property type="entry name" value="HTH_51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="10">
        <location>
            <begin position="337"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="11">
        <location>
            <begin position="1237"/>
            <end position="1549"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="1646"/>
            <end position="1722"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="7">
        <location>
            <begin position="1237"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="7">
        <location>
            <begin position="1395"/>
            <end position="1549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1556"/>
            <end position="1577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1620"/>
            <end position="1644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1620"/>
            <end position="1633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI09437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="2141" mass="232785" checksum="C57202D00C39275D" modified="2018-11-07" version="1">MSAQQPSLLVCGSLITNPDGTHLSRLRSALLHHPQLAELRGAVAELGLLWNLLAAKEPRLQRIGALPLVDVLADWLTSGGNSSGPVPFSVQTAGNAILAVLTVLSHIIEYVTYLDRHSPDGQDGHAESLEALREGGIQGLCVGLLSAIALACSRDRSDISRHGAVAVRLALCVGAYVDLEEATALEPSVCFSARWSPRQDHDPLQPVLDSYPQAYTSVRMDACSVTITAPRGTAIPLMDRLKNDGAVVKQMELRGRFHHKGHWPVFRQLAHLCASTPMLRFPPPSQLLVPVRRNDEAGLSHEAPLHDMALQCILVEEADWSATLGQTVMAMADNGRGALALILGPLESVPRSVLTASAVRPVRAAAGEEEAAYYPDHAMAVIGASCRFPLAETLDDFWETVKNKRSGSSLKSSSSFDCGLFGKSPREAEYLDPQHRLGLHLAYEALESAGLLAPTGTKDDNIGCYVGMSSSDYADNVNGRPATAFSYTGTARAFASGQISHFFGLTGPSMVVDTACSSSAVAIHTACAAIQAGECSMALAGGLNLMTEDGRAHRNLAAASFLSPSGRCRPFDAAADGYCRGEGGGFVLLKRLSAAVADNDRILGVLAGSAVNHGKGSRSITLPSSESQSQLYLRVLRLAGMRPQHVSYIEAHGTGTQKGDPVEMQSIRRVFGRALAGPPLRLGSVKANIGHAEAASGIAALLKVLLMLRHATVPPQTGFSVLNPVIPPLQTAKLEIPTRSAPWTGSFRTALVSNYGASGANVAMLVCQPPSSLLRPEPPVRPSRHPVLIAAHSAASLQRYCQSLLSLIAGQRNRLGDGLVPSIAFGLAHRQNQRLPFRALFCVRSTNELVSQLRSQEAAAQAEARVEAKPVVLLFAGQTGRGWRLSRTAYASSSLLRQHLDRCDRTLQMLGIDSLFPLIFDSGSVEDDIVHRHCMLFSLQYSVAVSWIDAGLEIAAMVGHSLGQLTALCVSGVLSLRDGLRLISGRASLIRDRWGSERGCMLRVDADAATLEAIIQQTKPSKVEVACYNATAHHVVVGTEAALTVFEKAARSVSVSVKKMTVSHGFHSEMVDCIIPEYRRLIQGLVLHQPSIPVEACTESGQGWADLSPELIARQSREPVYFAHAISRLEKRLGSCVWVEAGSGSVGTTMARRALDSRPGHSFHSIQLDDDLDPMASLADTTVGLWRQGVPVQFWQHHASQRADFAPLELPSYQFDMSQHWLPIIDQKEEQAAPHQPTLVSMLTQTQGHEATVEFAINQESEEYATFVRGRTVFGQVLAPASVYIESAARAFSLLPLRCSSSAHPPSESVEVADVKLHAPFGLDLNKRLRLTLRKHKGSSWHFAVESSPLGLDSYKLLASGTIRWQGNDNAYLDPHRPLLLRLGDRCQQLREDRSASVVQGAFVKRMMGRTAVYDDDYFGIQSIASKALEAVGCVSMPVMASRCSAETVFSPPILDNFLLVAELHASSLAELGNDHIYVCSGFDVVVPQSSSSETASEYQGPWTVLSSLDQESDRKVICDIFVFSAHHNALFLAIMGVRFNKISIRSFRKEMQAANGTRQVDESVPSEASEGHRLPERSSDEAINAMRGLQDFGEELSDANLAHQQVDRGLRRRASLTSLVTSTDDSTDSLGTPSKQSLLQPGPDFPSEKQAVALLNLLKEHLNSSQGIPLSTPLSTIGLDSLGAIQLQSDMERMFGKRPALTKIDENATFSDLYGMLCSREPDGLPRESPNAMKLHLQGHNLRPFFAALHISQESDDLVNHVTLALGRVNRDISTCAQKTGFAGFFSGVYQKQMSLVQAYILEAFSSLGCDLKSLREGEDLPDVQHAPKYERLVSRFCDVLQDMGLIGASTRGSLGYRTGTPLPTRSSSAELHDGLLTDCPRYRPEHRLLDVTGSSLADCLSGRADPLQLIFRDEASIQLLEDVYVDSPMFATGNEMLGDFIGHLVSDYQRHGDTDRLRILEIGAGTGATTQLVVDRLLEHDISFSYTFTDVSVALTASARKRFKSRYGRHKPRCNIEFTALDIEKPPPASMVQSYDLIISSNCIHATRDLQQSCLNMEELLRRDGGMLCLLELTRPLAWLDCVFGLLDGWWRFEDGRGYALADEHEWEKKLLNAGFRHVGWSDDGSPESQQFRLIVACR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5Y8</accession>
    <name>A0A367L5Y8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_4164</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5Y8"/>
    <dbReference type="STRING" id="1330021.A0A367L5Y8"/>
    <dbReference type="OrthoDB" id="4928185at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016711038" evidence="2">
        <location>
            <begin position="17"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI09632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="293" mass="31782" checksum="9149A149A023B429" modified="2018-11-07" version="1">MKSISVLAVAVGLVSAASVPPQLAERSLFMPSLKDFFRREDRAQNGTASRGSGQNGNNNNNNNENNRNNENNRNNGNNNNNNNNGNIQNLNGNDLNNLLQQSQQCQGFIQNNCNLNFNGNQNFNSNQNFNNNQNENNNNNNNNNNIQNLNSNDLNNLLQQSSQCQAFIQSGCNFNNNNNLINGQNFNNFGQQMIAVLAGNVHQLAVNLSPQIGQVVTVSAVSSLNPVQVIQLNNVLSFVPMMGQILVSQGLQASNINSMLVQPIVSSINSNGLNLNSIQGGVESIKSVNVVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L635</accession>
    <name>A0A367L635_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_3879</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L635"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI09884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="79" mass="9097" checksum="EFC28BD0FE14CED1" modified="2018-11-07" version="1">MDPKTIFFYPGKRRDEWRQCLLQSSVGGSGQLYEADVEMCISTAYIRTVRTILYEYRQRSLAAKCTEAALPALHKRPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6E5</accession>
    <name>A0A367L6E5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6E5"/>
    <dbReference type="STRING" id="1330021.A0A367L6E5"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="209" mass="23330" checksum="AEF50A87B9E142D4" modified="2018-11-07" version="1">MPVRISDCTAEDAPGLAAVLYADWLDPDPWTKLCYGAVDAHEQLVHLEAVIREDLTDPEYPVAFQKARDDDTAEIVGFTQLTHLNTPANERGQVAPIPKPAGYNVPPIRDYYAKMSTARKRVMGDDPFLRKHLPFYLTEMYIKKPYQRHGLGTSLMAWATEYAASKKLPIYAEASEAGEAFYKHLGWKTVGTYSVDMGLYGASPQRASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6I7</accession>
    <name>A0A367L6I7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_8564</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6I7"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI10019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="86" mass="9166" checksum="185F4B577B8F02C2" modified="2018-11-07" version="1">MSHVCACVASPTNRGFTCWSPARFGALALGFGRAVIGRHSCFSSLLFAPVPEQRHGKICRPPKGGSRAYRPKSLDLVPDQGVIVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L708</accession>
    <name>A0A367L708_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8686</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L708"/>
    <dbReference type="OrthoDB" id="4928254at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="149"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="249" mass="26709" checksum="82918E03E66FEA56" modified="2018-11-07" version="1">MLHTPTVGARDESSTVSAGPNPVEMAPVAVEGGDDVNGEEKPELNIALEPINGKADVGDEGKEKKKKEEETIDDDNDDDDNDDDDDDDDEKKEKQKQKKMMIMEAATTDDDNDADGGEKKKKKKEEEEEEEEEATINDDDDDNDKKKATSSPAAPMPASTAIDSIGSMPLAAAAAAAAAAATTEKRKRPDDDQEQKPDATTKQPKLQAQTNGSARKVGRPRKDCAKNASATLMVGRTARKTRSQGPAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7J9</accession>
    <name>A0A367L7J9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">DNA replication complex GINS protein PSF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_4390</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The GINS complex plays an essential role in the initiation of DNA replication. Has a role in chromosome segregation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GINS2/PSF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7J9"/>
    <dbReference type="STRING" id="1330021.A0A367L7J9"/>
    <dbReference type="OrthoDB" id="1938138at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11712">
        <property type="entry name" value="GINS_A_psf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1020:FF:000001">
        <property type="entry name" value="DNA replication complex GINS protein PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007257">
        <property type="entry name" value="GINS_Psf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056784">
        <property type="entry name" value="PSF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12772">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12772:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25005">
        <property type="entry name" value="PSF2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028998">
        <property type="entry name" value="GINS_Psf2_subgr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4 8" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication complex GINS protein PSF2 N-terminal" evidence="11">
        <location>
            <begin position="11"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="GINS subunit" evidence="10">
        <location>
            <begin position="63"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="209"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="211"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="225"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR028998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI10403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="238" mass="26082" checksum="851EEEBB694C8FC3" modified="2018-11-07" version="1">MALPLPSGLVPSEIAFLCEMELVTIGPTAPLRPPHRGTLPLWLALLLKKQRRANIVPPPWLHPDSLRDLVKYETTIDTTAWAPPPPPPVRADARGNTRRLDDDAVLSPPFLPSCTADAPADALPYHWLELAEMLLAYAADDVYSASEVRSLLRDLQEVRAAKMRASTAQLKSGVDGVMSLRGVGAMELTANRAFIVAVIDGVRKIGATAEAARREEQDEQHPDQHDDDEPSDDDMQFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7L2</accession>
    <name>A0A367L7L2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Origin recognition complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_4392</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7L2"/>
    <dbReference type="STRING" id="1330021.A0A367L7L2"/>
    <dbReference type="OrthoDB" id="343623at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15492">
        <property type="entry name" value="PHD_BRPF_JADE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001597">
        <property type="entry name" value="Origin recognition complex subunit Orc4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049945">
        <property type="entry name" value="AAA_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016527">
        <property type="entry name" value="ORC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032705">
        <property type="entry name" value="ORC4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12087">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12087:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14629">
        <property type="entry name" value="ORC4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="12">
        <location>
            <begin position="152"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="211"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="222"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI10401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="711" mass="77822" checksum="6866A961917EF946" modified="2018-11-07" version="1">MEGEGTPTSGRRKRQTATGDDEGEAAKRRKLDEEARPPAANGSRPAIKLAALKGTKWDKGDIGDARMSRQPSTPTRGSPSYGKGKGGSGFGLRSRATKDGASDGPVKLRGILTPSKNRGRRLKSVYFEDLPKVARSRRAKEEEEDDDDDDDEIRCGICLKPDSRPPNEIILCDNCDFASHQVCSGVPVIPEGDWLCKSCSQEEVVQMVEKEKKKKKKKTADEAAAPTTTTTTTTTGSDVPEIANLDQHLRSLQRVLLDRCCGRRRIRMIGLEECYDKARQLVEQTVVAAEGNSMLLIGPRGCGKTTMMENMMVDLSREHRHLFHVVRLSGFIHTDDKVALKEIWRQLGKEMEVEDELVNRTNYADTLASLLALLSHPSEITGRDEGGVTSQSVVFIIDEFDMFAGHGRQTLLYNLLDIAQSRKAPIAVVGCTTRLDVVEMLEKRVKSRFSHRCIYVSPPRSLAGFWQVCRQGLVVEWPDVGAEGIDAGVEGWDEFHAYWSRKIEELYEQRSFQDLLRYHFYTTKSAAAFMAEWVLPLTQLSATKTMDLLRCCGEEGDFSTTTTTTTTVVGPPPRSRLEPLLSTLSDLDLGMLIAAARLDVVADTSTVNFAMAYDEYGSLVARQRLQSATSGLLASGGGGVGEGVAAVAWERLISLGLLASVTGGAGTGKSGGGGGGQGGLEGRMWRVEVKLEEIPGAVELSPVLGRWCREM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7R5</accession>
    <name>A0A367L7R5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_4478</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7R5"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI10454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="119" mass="13368" checksum="99C6CA2619BB2A4A" modified="2018-11-07" version="1" fragment="single">PKARHNALSHSRAIARSSQRSARCTYSGYSTRLISAQGSRYIDRRAVLIAVIALDYDRRAVLIAVIAPDLDSRTKEGGFPTYFQFIISFNFITSLIQSPLLPSILLQSSQNHYHQLPAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L829</accession>
    <name>A0A367L829_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_4241</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L829"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI10575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="52" mass="6120" checksum="7274722BC5561C3B" modified="2018-11-07" version="1">MSNQGVDHVIEKKKTNHVIVVFNKVEADNKLEYNNVAIRHTFPFYDYRGRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L854</accession>
    <name>A0A367L854_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="7">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_4408</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cell membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Vacuole membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="7"/>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L854"/>
    <dbReference type="STRING" id="1330021.A0A367L854"/>
    <dbReference type="OrthoDB" id="3349449at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039756">
        <property type="entry name" value="Lsb6/PI4K2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12865">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE TYPE-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="9">
        <location>
            <begin position="162"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="321"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="409"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="633"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="708"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="429"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="663"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI10599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="768" mass="85870" checksum="86D6F1C9A218C4F9" modified="2018-11-07" version="1">MPRDRPPATGYERLAQADRGSDDSDDDHPLAESFSSLQPSSVPRYTSISQPRHRSGLSSPRPHSTRPKYRRRVGSNAGVDLKAINARLERWADEIASRFKRSRSKSHFGEEERLEIHHSVFQPPEGVRPITAEAMAESPPQAMTTTEFDAVVESVRTAIRQEIHPSMISQGSSGSYFARNPDGKIVGVFKPKDEEPYAAGNPKWNKWIHRNLFPCCFGRACLIPNLSYVSEAAAYVLDCQLRTGLVPYTDVVWLSSKSFHYPFWDRRGFYRKKKPLPAKPGSFQVFLKGFKDANVFLREHPWPDQYLSGFRASDTHRNKRKRWGESCRLSTSGSPEAGDSSDEESPDPRDQPAGPPQFAWTEPLKQSFREELEKLVILDYIMRNTDRGLDNWMVKVDWEAERVSLASEPMHLSMESPSDAVGPRPVEMSPPAASSASYPYKTQQPMEASSRRPAGSEPSMSIGAIDNSLSWPWKHPDAWRSFPFGWLFLPVDLIGRPFSKKTRDHFLPLLTSTAWWSQTQLALKRVFQVDEDFQERMFAKQMAVMKGQAWNVVEALKSPDHGPLELTRRARVCVWDDLVDVPVAVPMRVTSSELRRTHMRQSMDEADIASSAPNQHVPVEELISSPVVDIPRSCRFDMSAPGGGGGGGDDDDASTDDRAAQAPQPSRGTGSYQGPARSLHFYEPARRGSHSRQQGESHHQRRYSIATLAGRRGSSSSGHVLGGGGGGDDDLDGDLGYAAAEGQMANQRKVIVERLEAVKSRNPVFTWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8C1</accession>
    <name>A0A367L8C1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8C1"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="129" mass="13537" checksum="3E03E735CE431933" modified="2018-11-07" version="1" fragment="single">FGGSARHSHTHTQGTRPEGLGGSRDAGPAVAGPRPPYVTEAERHNNVGGGYGTATPYSGYGRTGRTGRTRPEGLGGSRDAGPAVAGPRPPYVTEAVRHSGCTRRLRHGYAVQRLRPYGPYGPYEGRNVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8F9</accession>
    <name>A0A367L8F9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YMC020W-like alpha/beta hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_5304</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8F9"/>
    <dbReference type="OrthoDB" id="5598028at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058934">
        <property type="entry name" value="YMC020W-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058933">
        <property type="entry name" value="YMC020W-like_ab_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47349:SF1">
        <property type="entry name" value="AER328WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47349">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26147">
        <property type="entry name" value="AB_HYDROLASE_YMC0-YMC35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YMC020W-like alpha/beta hydrolase" evidence="2">
        <location>
            <begin position="355"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI10718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="770" mass="83819" checksum="51D5265D75A64225" modified="2018-11-07" version="1">MLPRKRQRPNPTTAVSREVATPQNVSSALGPPPLLLRSHRSIAALSAGKAAEKQLRKSTSWYGVWPSKATASTSIARENILAATLRSTRPADLARFEMSQPRESDEGESCSNPQAAESDKNDDVAAAAVKDIPSHPLRPATSYSWLGWLAGATIDEDGQKQQDEGGACLAQNSQTVEQRPRPLERQTEEKSPATTKTTSLTVTEPMSPLSWFGLWPAYYHIDSPRCPTMHTADDATMAEPTPPPSPPNTNNNNNNNNNNNNNKKADAVVPKAGSTWAFWSTNRGAGEVAVMGEASENHPLPTTAMMVPEKSRQSNNKRARPPSPTPSDTPAEASTTTTTTTTTTPTPTPTANVVLPCFSTTYSIKERPSVLQQLAEWVLPHHRPQPTAHVTRSPEPRRIRKAVAIGVHGLIPAAYLRPMIGQPTGTSLRLASLCGESLRRWADSNGCPDCQVQTIALEGEGRIGDRVDNLWRLLLNWMDALRRADCVLIAAHSQGVPVAVMLLQRLVDFGILDSQARIGICAMAGVTLGPFSDFRSGLLPSSAAELWDLADGKSAISLKFQASLGRILDAGARVSLVASLDDQLVPLDSALYAPAHHPYIHRSVFVDGRLLQGDLTSPHRRNRPDFIAMLVSLALKLRNLGQDDHGLLRELARPLAGSLYSGEGHSRLYYDAAVYDVAVAHLLETDDLAVGPSRHPPVRVEAYDAVVDVAGQQNPYLLPWIMRGLLDDASLHRGLREDSADLLRQFDGWRPATKALKDVKYRLEAIRSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8S0</accession>
    <name>A0A367L8S0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5406</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8S0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="108" mass="12369" checksum="8EF18BAAD67D7D34" modified="2018-11-07" version="1">MGYVRVLQVGTLKYLEKIISISFSHLLNTNTSPASNSSSIASFRPSRDSSSSSLSPRVQLSNSGYLYTFNQLFTAFLFLHRPTKYLIRFHFSDAFQQTYPLFPHIFPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L941</accession>
    <name>A0A367L941_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5368</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L941"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI10752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="84" mass="9695" checksum="CB041B21D3407257" modified="2018-11-07" version="1" fragment="single">EEEEESRDSLKEAIKEELEAGEVFVLRRYFSRYFKVSTYSTLTYLYKIGDLEEDLYVPYPAVSAVLRGCGYGLGRICSICFKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L945</accession>
    <name>A0A367L945_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alpha-1,3-glucosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_5315</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the second glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Glc(1)Man(9)GlcNAc(2)-PP-Dol to produce Glc(2)Man(9)GlcNAc(2)-PP-Dol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate = an alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31307"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="Rhea" id="RHEA-COMP:19521"/>
            <dbReference type="Rhea" id="RHEA-COMP:19522"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:132521"/>
            <dbReference type="ChEBI" id="CHEBI:132522"/>
            <dbReference type="EC" id="2.4.1.265"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:31308"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L945"/>
    <dbReference type="STRING" id="1330021.A0A367L945"/>
    <dbReference type="OrthoDB" id="1689333at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042283">
        <property type="term" value="F:dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413">
        <property type="entry name" value="DOLICHYL GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413:SF2">
        <property type="entry name" value="DOLICHYL PYROPHOSPHATE GLC1MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03155">
        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="372"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="394"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="416"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="480"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI10950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="506" mass="56913" checksum="7BB65FEC249B55A7" modified="2018-11-07" version="1">MPAIVAEPYPTLTQCAVVATAFKILLFPAYKSTDFEVHRNWLAITRSLPISEWYFDETSPWTLDYPPFFAHWEWLLAHVARLVDPAMVKLYSVGHESWPTVCFQRASVVVAEVLLVFALHLFVEWSPSASRRAAQTAALSIFLSPGLLIIDHIHFQYNGFLYGFLVLSLVLARRKTMLLHSAVVFAALLCFKHIYLYLAPAYFVFLLRAYCLSARPIWRPDMVNCVKLGLSVSAVFAAAFGPFVMMGQMPQLLRRLFPFSRGLCHAYWAPNVWALYSLADRILIRLAPLLGLPLKTEALQSVTRGLVGDTSFAVLPDVTPRTCFVLTVLFQAPALVKMLVKSTRPTWEDLVGAVTLCGYAAFLFGWHVHEKAILLVVIPFSLVALRDRRHLSAFRPLAVAAHVSLFPLVFTPAEFPIKTVYTILWLVLFLLAFDRLAPASDKRRIFLLDRFSTLYIAGSVPLIAYASLLHRAVLGERLEFLPLMFISGYSAVGVIGSWVGFMVVHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L961</accession>
    <name>A0A367L961_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcriptional repressor Tup1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_5319</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L961"/>
    <dbReference type="STRING" id="1330021.A0A367L961"/>
    <dbReference type="OrthoDB" id="17410at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000111">
        <property type="entry name" value="Transcriptional repressor rco-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013890">
        <property type="entry name" value="Tscrpt_rep_Tup1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08581">
        <property type="entry name" value="Tup_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Transcriptional repressor Tup1 N-terminal" evidence="8">
        <location>
            <begin position="19"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="347"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="382"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="430"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="468"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="521"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="563"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="87"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI10944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="599" mass="64975" checksum="540E589185C1D764" modified="2018-11-07" version="1">MSMYSHRGMGAVPQGNSVRINELLDQIRAEFETQLRQTEGFEHQISAQVSEMQLVREKVYAMEQTHMTLKQKYEEEISMLRHQLEAARKGGPQPGMPGPPQHPGPSQQPPSIAPGNGLFSGIMAGGNQAGLAPPQQHPPPQEQQVGPQHQMAQGPPGLPVPPPHPNAQQPPYQQPYPQGPVSNGMGPQPPQSTASPGPGRRGVGRPPHAVGPATPQINTPVPYPGNAQSPQVSHPTPDHARMGGPRAPPVGNSLGDLEVEAVAPHNKKTGSDWHAIFNPQVQRVLDVELVHSLPHESVVCCVRFSHDGKYVATGCNRSAQIYDVQTGEKVCVLEDHNAQDMSADLYIRSVCFSPDGRYLATGAEDKLIRVWDIATRTIRNHFAGHEQDIYSLDFARDGHTIASGSGDRTVRLWDIEQGTCTLTLTIEDGVTTVAISPDTQFVAAGSLDKSVRVWDIRSGFLVERLEGSDGHKDSVYSVAFSPNGKDLVSGSLDRTIKMWELSVPRGNGTTGPKGGKCVKTFEGHRDFVLSVALTPDANWVLSGSKDRGVQFWDPRTGTTQLMLQGHKNSVISVAPSPQGMYFATGSGDMKARIWSYRPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9J8</accession>
    <name>A0A367L9J8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7181</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9J8"/>
    <dbReference type="STRING" id="1330021.A0A367L9J8"/>
    <dbReference type="OrthoDB" id="3641511at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="68"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="230" mass="25697" checksum="B6F8AE36563FBE55" modified="2018-11-07" version="1">MPGVSPRSSGLTSPQKHQLLPAKHNMENSLEQPDFPLAVSSLVTLTKQVSLCQNLPSVNEGRRLADVLDGLQRSVEGLRTDVEGLRTEVQGLRTEVQGLRTEVQGLRTEVQGLRTEVQVLRTEVRTMGGKLDQLDRKTTVINKNFTARIENSHVIHDEVKLVPLYSVVTGNLVPNFPKTLQDLDALTEQRVNFLLTQLGEEARGRPDDRRDQLEMALGVRARASKTSRRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9X9</accession>
    <name>A0A367L9X9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">U3 small nucleolar RNA-associated protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_7247</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in ribosome biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Component of the ribosomal small subunit (SSU) processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
            <location evidence="1 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the HEATR1/UTP10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367L9X9"/>
    <dbReference type="OrthoDB" id="31183at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012954">
        <property type="entry name" value="BP28_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056473">
        <property type="entry name" value="HEAT_Utp10/HEAT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022125">
        <property type="entry name" value="U3snoRNP10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040191">
        <property type="entry name" value="UTP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457">
        <property type="entry name" value="BAP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457:SF1">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08146">
        <property type="entry name" value="BP28CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23243">
        <property type="entry name" value="HEAT_HEATR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12397">
        <property type="entry name" value="U3snoRNP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01036">
        <property type="entry name" value="BP28CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="6 10" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="BP28 C-terminal" evidence="12">
        <location>
            <begin position="1541"/>
            <end position="1693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="890"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="906"/>
            <end position="916"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI11238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1823" mass="200932" checksum="158B8DF70422E612" modified="2018-11-07" version="1">MPTSLASQLAQLAANSKATLNTKAQKAAHSKSLIWEARVAATQSFQTLYATCYPGFEELCQLDPRFAHFRSTLFSDESQSQDRTQFTATENEELDRQIESFLHLVGSRLRLMPAITAIEWLIRRFRIHEENTAILLMTFLPYHSIPAFATLLSILPRQIPSEFRFLDNYIRSITLPPRPILVHQAIHHPEFLIAVSDYTLGSCRRHCHYPALITFWGGLMTEAIGGILDKIRSGRAAVQSDNTQSLLYRVGPIFAESLAMKKIPSLQIASYMALVLFVSKANLEDGAITAFMEQTVYGWTSDTIRPGLVCLTIMAQFRSAKQMSSKVTKALVKVPDIGHLLVEVSRERNVDKLANGFCLALIERFTKKGDLRGLAPIMAVLSSQVLKDTQIAVIFKSLLLTALRLDDGNDRDGSLRRELGSALISLTHTTGKSGDIIQSVIQDVDFDIEELEMKLDLSLRTKKLLGPTADAADETVSETTGRPQPVEDLEGAVKKLSAIQEPLPTCLLSKPSVSFDEFSRLFFAIVSEQSRQAAALTKFYDSPKLRRQYAFDDCTYFSFFVRIWCGPYPALARKASLDMVKKRLEAGDQGDVDLQALIPYCVVALGDPSKRVRRGAADLITVLTSLYAPPVAKGSMKIWGAGSLNGKSKDAVALSSPITARLLHLQILPCVEECVLDATHISSALNAAIVQGRYRLPPPPALDKKDHMSHSARLALLSFFADHVNTTPYLVVKERLLKALNEVRGVGTTTRTQVLLPTLQWWASLSEDEAEEVCRSEQLVRSELEPRFAAVLLPNDEAGMEFIFQTLNDPLKRGKTGLIRAIFARIRGTWPSMKNGLKLIYAEQLLKIALETTEGSDSSIAAGEAADVLRAVPLTTDILSSFLDSIQTGTKMITEPPPNKRRRTSTSDGNRGLASQVTPELSQALRKVTMVLQLVESSDPLSHPHLLHGLFSALSELHHFKTVVGAELGYLQNLILRSLLAMMPAYRSNKQLKIDSSGGYGDLLVNCIQKSTSPVVQNAALLLIADLATTAPDLVLHSVMPIFTFMGTSVLRQNDDYSAHVVSQTIKEVIPPLIETLQRGQKAVTGACNILVSFTTAYEHIPAHRQQGLFVALMKTLGPREFLFALISMLVNRYETSDALMRFIVDLFNNFDVETQLETLNKIVDLVSDLFRPKPDMSRILLGGSEGEAAPSARDVALRQLSALPSYLSNKTLKSKMEKLAERDDMEALQARALYAALLEKILSLADTVRSDKVLRGRCGAALSNLLNLLSIGKFIKAVEDLLDKQDVGLRHKVLQALEERVEAEKNPDPASRKGLLAFLPLLTAAIRESSDMRFKYTAVTCVDKIAEKYGKMDIEAVVAAATTIAGDCCLGQGERRLRIMALLCLTSLVDVLQDAVVPVLPVAMPTAIAYLNESLDGETPDQELHSACYGLLSSLAEHLPYMLSPYIDEVLAASNRSAETNAGKDANESRSTCLGILARQVDAKDLFASLERNWEKAMAAGLSVSDSTCPTPERGAASNGRQAVLELIEMLGAAINKHHKSVISKNATLLMNIFLQALDVRRRAHAAGTADGLVLEKVSRVESEAGEKALKMIYKFNDAAFRPLFANMMEWTTRGLEGDRSGRVLRQCSVYGFLEHFFGQLKSIVTSYAAYVVDDAVKTLRTIRVKDAGERQLWGRVLKTLATCFEHDQDEFWQAPAHFGEVAPLLTAQLLLAGSVNVMEGVVPAVVELAAAAGSQKNQRDLNGALMKHLKSEQAAVRLAAVRCQQALMERLGEEWLAMLHEMLPRISELQEDDDEEVERETHRWIVKIEGVLGESLDAMPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LA00</accession>
    <name>A0A367LA00_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7707</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LA00"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI11257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="49" mass="5515" checksum="1CA270C9A28BF75B" modified="2018-11-07" version="1" fragment="single">MRKIALCLSLSHIVPRWLTGDFAKQASVDRWKTTLPDLDYLGSQVISPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAK9</accession>
    <name>A0A367LAK9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein L19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_7194</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAK9"/>
    <dbReference type="STRING" id="1330021.A0A367LAK9"/>
    <dbReference type="OrthoDB" id="432645at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001857">
        <property type="entry name" value="Ribosomal_bL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038657">
        <property type="entry name" value="Ribosomal_bL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680:SF9">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15680">
        <property type="entry name" value="RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01245">
        <property type="entry name" value="Ribosomal_L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI11468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="216" mass="24921" checksum="26F52616BC21C65F" modified="2018-11-07" version="1">MNAIAVAVARRPTSCLKEAVWLTRRTYATTTALAPPRDQGSYTLRQRNWKAKLADFQVWPQMPTMKSTPPDPMPAVKQKFIDKMDMSGARTQIFSKERRDCARVGDVLMVTTDGLEPFAGVFIQIHRSGPDTSILLRGNLMNTGVERWFKIYSPSVTAINIISRRRRRSRRARLTYMRHPKHDMGNVDELVLEWKKERQALSTKATQKVDEFKRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAU8</accession>
    <name>A0A367LAU8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase M43 pregnancy-associated plasma-A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_7730</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Secreted metalloproteinase that allows assimilation of proteinaceous substrates.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M43B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAU8"/>
    <dbReference type="STRING" id="1330021.A0A367LAU8"/>
    <dbReference type="OrthoDB" id="536211at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008754">
        <property type="entry name" value="Peptidase_M43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47466">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47466:SF1">
        <property type="entry name" value="METALLOPROTEASE MEP1 (AFU_ORTHOLOGUE AFUA_1G07730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05572">
        <property type="entry name" value="Peptidase_M43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M43 pregnancy-associated plasma-A" evidence="10">
        <location>
            <begin position="453"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI11534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="651" mass="72303" checksum="EBBF545991708AD5" modified="2018-11-07" version="1">MQWSCQHEREHVIHIDTSGKVTTSRLVNKYDFTFNFKQSPANITFIDYKTDEAPTFGNSSARAGGLSAYSSKYIMATSSLSTQIPYRRVLRDACSLLLILALQPSTGNLPEGTAVGQRIKAPDRDFHPAPSHSDSKYKRLARVPAHLPKINTSSLMLLWSRHPRKSSSFMLPIYPSVVASLDIVHPSCPSSYYENKIYVSALNPLGAEAYAGENIVAQGGAYITQVVSSPWDGYNINIVHSSCPSSSTVTASTMLLFTSLVSLVGVTAALDASLSGIRRRPSFFDRPLKETDSISPGMPRPIPDRKPRNVIVDGVDSFQPIHVEVYANIVSSSNSTEHLSLGALENQIQIVNHWFGPLNMSFSIVETRRIVDDTWATGDDSFNMVIHNHQGTSASLNLFIIETITSSDLVGICTYPNAVEYAPKVDGCVLVLRAIPGAPESATGYDAVQWQGKALIHEIGHWFGLRETFHRGCDGDEIDDIPASLPSHGCPVGLDSCPDKPGLDPIHNFMSHNNESCKREFSAGQIRRMHHNWHRHRAQARAAELKGLPLLKPFLEQVGKLPFYENYEKDVVMIFALCARDHHGVVRERDERRCGSYWYCHFGLYRTDENAAGSWHSKGECLRARALSERMLHDVELEEQVTVEEDKAKAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAW9</accession>
    <name>A0A367LAW9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_7566</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAW9"/>
    <dbReference type="STRING" id="1330021.A0A367LAW9"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000058">
        <property type="entry name" value="AP complex subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="8">
        <location>
            <begin position="15"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="641"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="697"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="641"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="697"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI11563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="735" mass="80474" checksum="90B31A4042A93CDC" modified="2018-11-07" version="1">MAVNRIRGAFAAPRKGETFELRAGLVSQYAYERKESIQRTIMAMTLGKDVSALFPDVLKNIATSDLDQKKLVYLYLMNYAKSHPDLCILAVNTFVQDSEDPNPLVRALAIRTMGCIRVEKMVDYMEEPLRKTLRDESPYVRKTAAICVAKLFDLNPTMCIENGFLESLQELIGDPNPMVVANSVQALAEITETAPETRALVVTAPTLKKLLMALNECTEWGRITILSTLADYQSADAKESEHICERVVPQFQHVNPSVVLAAVKVVFIHMKSVNSELVRSYLKKMAPPLVTLVASASEVQYVALRNIDLLLQAKPDILSKELRVFFCKYNDPPYVKMQKLEIMVRIANEKNYEQLLAELKEYALEVDMDFVRRAVKAIGQVAIKIEDASAKCVQALEDLISTKVNYVVQEAVVVIKDILRKYPGYEGVIPTLCKHIDELDEPNARGSLIWIVGEYAEKIKNAEQILESFVEGFMEEFTQTQLQILTATVKLFLKKPGNSQGLVQKVLQAATSENDNPDIRDRAYVYWRLLSGDLGVAKSIILSQKPTIASTMTCLPPAMLEQLLAELSTLASVYHKPPESFVGKGRFGADEIQRAAILEQRQNAAEDPIMATMAAANGAAGGAPRSNLENLLDIDFDGAAPASQEQQSASAGATPDRVASPTSASGGGMADMMSMLDAPVSSSSGVGSGMNDLMGGFEGLNFGGSGSSQPLPAAMQLQSQGTQEKKDSDDLLGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LB26</accession>
    <name>A0A367LB26_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7653</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LB26"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI11621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="44" mass="5058" checksum="FF58D5D60E1447BC" modified="2018-11-07" version="1" fragment="single">MPNSSYLTTSPPLLSTPSRSFCLKRLYLIGRSTRPFRLTRNART</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LB72</accession>
    <name>A0A367LB72_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_7729</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LB72"/>
    <dbReference type="STRING" id="1330021.A0A367LB72"/>
    <dbReference type="OrthoDB" id="2269373at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF85">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="17"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="78"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="636"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="448"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="645"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="666"/>
            <end position="705"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI11666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="769" mass="86352" checksum="888717B041B044FB" modified="2018-11-07" version="1">MSANPVPHPPRNARVLACVLCQHRKIKCDRKFPCANCIKANVSCTPSTPAPARKRRRPNQDLQERLSRCEELLKQYAGAAASPAPHGEPSPSGPVKVDPEPKPEPVEPDVNGWKPGCKMVPDEGGARFMDSYIWASVYEELQAMRDIVETDDPEDASILGSEDLTPDNNNTDLLFHGEVVTANLDDLQPDPALGFKLWQLFIDRVNPLTKIIHVPSVQPWVVDAAGGIAGLPPQRQALLFSIYSMAIISLSDAECQQTLGVSRDAALQRFNAGTKAALTRLNFLKNYHMAALQALVLYMYSLQGRFDRHAAWILGGTVVRIAQKMGYHRDGELLRLDPFQTEMRRRIWWQIVVQDSKFAMLSGLRQTMLPLRWDTKMPRNLNDADMVPGSTEPMAAREGPTEMAFCLIINEIYRFKMQADEANDGSACEAAMLGQAGSSDADGPNEAFDRFRWRAKELQTRLEELERRFVDVNAGSVHKAALSIRPMVTNKLSEMLVPAREQPEWGTEIFGPKDSLFKVVILGNEQRMDAFDSLEPTGFIWFVKLNFQPDMFAVMMGQLCQRPTGSLAERAWAVAERAYDNHSELSDMTHRTSAVQAQFTLKAWRARERAFLQAGRPLETRPFIQRLRELAPWPQEGIGRSWSVPSSATPPMATTPRRPTQPPLFQPQQQQQQQQQQQQQQHNQHQHQPQQQPQQQQQQQQPPQQNGDADPLLGGYLDMEMLDWDMFGDMVGAGGDHQLSAAMFGGLGLPNMPGMGQTSPTTQYTRKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LB92</accession>
    <name>A0A367LB92_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Superkiller protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_7575</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LB92"/>
    <dbReference type="OrthoDB" id="421075at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039226">
        <property type="entry name" value="Ski3/TTC37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040962">
        <property type="entry name" value="TPR_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704">
        <property type="entry name" value="SUPERKILLER 3 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15704:SF7">
        <property type="entry name" value="SUPERKILLER COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18833">
        <property type="entry name" value="TPR_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="370"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="453"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="651"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="727"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="986"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="320"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI11693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1426" mass="156604" checksum="5C8E3202A0C9AFAE" modified="2018-11-07" version="1">MSGIKGMLRSINEAIRQNKFDEAAKIAGDLLQKDANNYQGRVFLAFALDNKNEPTEAENVYLAAVATRPQDPQAYQGLVKLYEKQGAPKLAAYQRVVTSLAKVLADAGEAYKSQDVVDKFVDFARCHGSPLEYADALWIRLPESPLYPVLEGRFPPPAQTYESIVRIVEDAEKKRINKLIGERRTRLGAVLTDVTVEVKREVYGQSKLEHLYRQLINWTAHDEVRRTYEEKVLQYCYDRLAVLPPAAKPEQQAVVLGLARDMVIINHPFKLAWDIAINWQDNKEISDWDAGLLRSYCSSFPDADLYKVLRAYLTSSFSPFPERQEETESSAANSEESEDDDDGGAPTSLPLTDVDRLVMMTEGISATESTLAYRLVGHYFLQLGEYETTVEYMRKALQYLNKERTKNGLSFRNTQDAYALCLATALVYYQSPRHHQEAKSLFDGVLEHDQTRTSALLGVGLVYEEEQEYEQAIDFLSRALERDESNLRVKTEAAWVKALKGDWQTAKDELTSCIEPLEAQGAVAKELLADTQHRVGCCMWNLDTSRQARKQRKGDCAYSYWLAALGNNMKLAPAYTSLGVYYRDYAKDRKRARRCFQKALELSSAEVISAQSLAQSFAEDADWERVELVARRVVDSGVVKPPPGSKRRGISWPFSALGVAELNKQDFHKAIVSFQSALKLSPDDYHSWVGLGESYHSSGRYVAATKAILNAQELEADDGRDVEADTWFTKYMLANIKRELGEYDEAMVLYRSVLESRPEEEGVILALLQTIADNALVSVEKGFFGKAVQLAIDTIDVAAGATPEKVKGTFNFWKSVAEACSVFTSVQSRAADFPTQAIRALLEAGDQEAYRFLANVDKVGTDVVCAGGIYPEDEQSGVDRTRCVHATILCHKQAIRVSSGDQHAQAVAHYNLGWAEHRAHACLPYHLRRRPSSYLRAAVRAFKRSIELESGNAEFWNALGVATSKINPAISQHALVRSLHLNERSPATWTNLGTLALLSRDLKLANEAYTRAQSADPDYAHAWLGQAFIALLAGDAKEARSLFTHAMDIAGASSLPSRRHYAASVFDHVLSGAPGCTTPVSLIQPLFALGQVGSLRPQDLVFMHLATLFQERTRDSARATRTLEDMCSVIEADYETTESAESLVRFTLAKADLARAYLSGGSYEQAVECGETALGLSGEEGEGELTAEQRKRARLSAHLTTGLGHFFLGAFDEAEKALKAALEESGGDPDAACLLAQALWAQGSEESRQRARSVLLDVVETRPDHAQSVLLLGAVALLDEDQDGLEAVAEALHGLRAGDGVTAAEQGQAGDVLGAIAMAGAADDDSSREDELLAQMQTDVMLRPYLPDGWGSLAKTTGDGQAAAMALRVAARGIPPRGALEAEQLARAYAGTGTAADAQRAVVVAPWAAAGWKALRATTEGICIGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBV4</accession>
    <name>A0A367LBV4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_4193</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000009">
        <property type="protein sequence ID" value="RCI11909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBV4"/>
    <dbReference type="STRING" id="1330021.A0A367LBV4"/>
    <dbReference type="OrthoDB" id="273181at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033260">
        <property type="term" value="P:nuclear DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000110">
        <property type="entry name" value="PPS1p Protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053239">
        <property type="entry name" value="Dual_spec_PTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47550">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE PPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47550:SF1">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE PPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="4">
        <location>
            <begin position="519"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="5">
        <location>
            <begin position="579"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="15"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI11909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="694" mass="77482" checksum="34FF9E96EFE352F6" modified="2018-11-07" version="1">MATVALSRAIQHKTTSNLPHAIKPVHKLDDVGSSPPPPSGPCIPPSPNNFFATCSTDSTGVDADTLLSSPKGLDETRQKSLLYPPEGYVRVDAGRLSIYEITADQIAQAVDFAARQPLPPVSLVFPWLHGLNPNNQIQQAFFMNRCRSLRKTPSCLRGVTLVKANGDLSVGRLKGAIAPEEFMRRSAGSTAFIEADPVDGFSVRNFQIQTAKVAFTSDLVIYGDDLVEARKVSWDVAGAQSQWREQHASQGYPLPHYNTFLCTSTIQDFEDSHDDLVSIDSYGKCTGKVLDLAQQERREQWNMTQTSEISHNVFMGPTPKLRSDEVKKFDILIECSDLGRLNPTALRVIAEKMEDQGTQVFVDFPSSGSILPPTWSNDEADSILETCRWIFHLSHGIRASVDGSNAHCYGDASQCERQPRTSRPRKILIHCADGYTESSMLGIAYLSFSIGCPVHEAWLVLHTSKRRNFFAYPTDVALLTALSPRLLQESPICAGRPSVDTMKMFSSEPSWLQWLDGSFPSRILDYLYLGNLGHANNPDLLKELGIRQILSVGETVAWRDGELDAWGPENVCVVQEVQDNGIDTLSDQFDRCLEFIGEVATLVHCRVGVSRSATICIAEVMRAYRMTLPRAYCFVRARRLNVIIQPHLQFIYELLKWEEHLRRGGGGSESWIKRELEWGEMAREIASMNRPYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBW2</accession>
    <name>A0A367LBW2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PRA1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_4217</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000009">
        <property type="protein sequence ID" value="RCI11905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBW2"/>
    <dbReference type="STRING" id="1330021.A0A367LBW2"/>
    <dbReference type="OrthoDB" id="63113at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004895">
        <property type="entry name" value="Prenylated_rab_accept_PRA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317">
        <property type="entry name" value="PRENYLATED RAB ACCEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317:SF0">
        <property type="entry name" value="PRENYLATED RAB ACCEPTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03208">
        <property type="entry name" value="PRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="219"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="330"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="292"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="234"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="457"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="507"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI11905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="531" mass="58459" checksum="3D882BCD8DA85F5D" modified="2018-11-07" version="1">MSRIQIPLDALTSRLNLSDRLQGFRPGPLTGRFSNLRPVSEFLDFKRVSKPANFAEMQSRVNYNLSHFSSNYAVVFSMLSIYALLTNWVLLFDIVLVVVGMFLIGRLEGRDLEIGTFRASSSQLYTGLLIVAVPLGLIASPFSTLLWLIGASGVAILGHASFMDKPIDEAFSGEARFWQHHARVEELDTEDGDDGGLDVQLQRGRRFVSDSLQFTGIDLGDRTGDMVSRRPRDEDDYDDDDDDDDDTCSDEDDEDEDEAEDDGGGDDSEEEGLVQSALQRIDRARARGKADVRLNKDELAALERRRRRMREDEERRRRRARVAVPLTHLEPISRPRPAGAATTMYGTSDQPRHVSAGSMVEAPGPEQRQALPPMGYFAPPVSSHPRLRSGASSTTTTTSRHVSDSATRLRSIRYSPPDDNSLPPASRTHLDPFVYQTAGPRQGVGRRHVSGPAEMSSGRRGEPRPRSYGDETSSDEGESSGSGVVSSRLRERPARGRVVAEASSSPARKKGSPASAKKKASSSSGGKRRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCE4</accession>
    <name>A0A367LCE4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Piwi domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_0080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCE4"/>
    <dbReference type="STRING" id="1330021.A0A367LCE4"/>
    <dbReference type="OrthoDB" id="10252740at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04657">
        <property type="entry name" value="Piwi_ago-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032472">
        <property type="entry name" value="ArgoL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045246">
        <property type="entry name" value="Piwi_ago-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16488">
        <property type="entry name" value="ArgoL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="2">
        <location>
            <begin position="335"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="3">
        <location>
            <begin position="622"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI12090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="996" mass="111361" checksum="E3A7B9BB031EC11C" modified="2018-11-07" version="1">MSDRGRSPLPKAGGNPSGSRGTSPARSAARPSQPGAPSDILVPKGFEPAKPMGFDPAKPVGKKAPQGNTRMELPADAYVADTQKSVFALRGNKVNTEGKPISIEVNQYRMKTFDFSKKIYQYDVSISPDLDKKAAVLRKIWMHETTKQTLAKYKYPMWIFDGRKLAWAPSSIERGEVRFQVDLDEGRKPPGEGSKRDNKFYVNIRQTTVVSMSALQGYLEQKVSFNTNVQTALNFIDHLIRQYPSQHLLSIKRNFYDQTQRGKPLMGAGSYVEAHKGLYASVRLSQNLKLGGIGLALNADVANTCFWQGNITLDQVVCHFLAACDRTWQGLNQVSAAQVLRPVKHHTGTWASSDAFKQLRKLRRLKFLIRHPNRANSEKVYTVVDFAFKPEYGPDGGNAKNVKFDYNGTKTSVEDFYDKKYSAHLRYSLLPVIDAGKNGYVPMEFAVLLPMQRYPFKLNPDQTSNMIRFAVTRPRERRADIERGVASLRFGQDPYLKEYGVTFEPSFAKTEAKLLAYPRVDFGQGQVDPKLTGRWDLRGKKFWKQNFAPLNNWAFVVMDACVDYPSLSAFAKSFRETFIGHGGKCPADALLLNAPADKKHNPAEVLAWAHGECMAKRGYPQLLFVVVGHRNSPHYERLKKSADCRFGVLSQVVNGEAVRKNNGQYLSNVCMKVNAKLGGATSRTMPPWKSPTYFPKDRPTMVIGVDVSHGSPGSNAPSTAAMTMSVDRDATRYAAMVETNGYRVEILTAVNVHFLFGQLADQWKTGHDGQFPKHIIYFRDGVSEGQFAQVLDQEVGEIKSFLRQKAPNLPQPKFTVVVATKRHHIRFFPSQGDKNGNALPGTLVEKEVTHPFMWDFYLCSHVAIQGTARPVHYHVILDEMNVPVNDFQKMIYQQCYSYARSTTPVSLHPAVYYAHLAGARARAHENIATSEGFRSGAKGHEMVRDKVAKGATIGSVPSGTESPALLTLGGKINPEKGPADGEQRQRDFFRSTMWYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LD35</accession>
    <name>A0A367LD35_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_0061</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LD35"/>
    <dbReference type="STRING" id="1330021.A0A367LD35"/>
    <dbReference type="OrthoDB" id="19690at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000245">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01068">
        <property type="entry name" value="thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="site" description="Deprotonates C-terminal active site Cys" evidence="4">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="4">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="4">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="5">
        <location>
            <begin position="31"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI12321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="105" mass="11707" checksum="AE6E9072FAB53BD2" modified="2018-11-07" version="1">MAVIEVKTAEEFKDLLKKHPKVAVDFYAEWCGPCKIISPVFKQLSEQHSDITFLSVDVDKLEAVAQEYGIRAMPTFIMFKDGEKSNELTGANKSGLEEKIQALAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDR1</accession>
    <name>A0A367LDR1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0832</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDR1"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="74" mass="8136" checksum="D5372E31B61A82FE" modified="2018-11-07" version="1">MPAAISLLRLATFILAIFLALLVSLPRLLDLRNPEDEVTALRISYEILLDILDMLVNEGDLTISSKAIAMLKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDV7</accession>
    <name>A0A367LDV7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_1021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDV7"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI12608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="62" mass="7164" checksum="30E3C800286A2D9F" modified="2018-11-07" version="1">MASNEEDIRRIAAIGYKEAIKFFPKEKQPTSPERIYKKSFNKANRKTIAPNLVLTKVDNLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDX7</accession>
    <name>A0A367LDX7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_1146</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDX7"/>
    <dbReference type="STRING" id="1330021.A0A367LDX7"/>
    <dbReference type="OrthoDB" id="4092340at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="255"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="173"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="397"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="437"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="506"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="525"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="549"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI12442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="558" mass="59502" checksum="9A9743B5E34B77FF" modified="2018-11-07" version="1">MDAGGLAQMSSNTFPPASGLAMSGNLATRRGSQNIKPLSFDAIKQSSNAKDGGVPTPRTSRSHLLAGLRTAPKSANAASFGTANSSVSAQQLAKNSMATNLSGYGQDSLLRNPPLTAFPQYGVQQSGFPAIIGHQQYTVDQVLAPPEITMDEQSQEHMDPNLYAQLVATNMYLAQQQQRLQQQLRSVQAAAQQFQQLNLSNPQLAQQQLSIYEQQQQLRNMQQQLGVQAALGQGQQVYYSPVTGQYYVDSSSMAPPMSSGFVEQQQQQQQQQPMSPVGNAFQQLPTPRVQVSPPPENQPSATFRNPSPPRRYDSPCEVTPLPPPSVNAFRRGHKKTSSLAPSISSSGGGELLSEMPKSAGPKASSFPLTPTTGSYGPGQARAGEHPIRQPRGPPALDELKSKPTAKHEGSKNFASRARRSAVHNLVRAGLERRKGAGSSPGSMSPSSETADDLATPMTDNDSDSGRSGSGILAGEMEYGSSRTPTSGGWGAIGSDRPNRRHKSRSSLESGECSNDSFAAVFKNAAPREAKAHDAAEGQRRASRLVLTSVEKRKATPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LE14</accession>
    <name>A0A367LE14_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TOM core complex subunit Tom6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0551</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LE14"/>
    <dbReference type="OrthoDB" id="5403997at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="76" mass="8455" checksum="2C655B0BC66DFD14" modified="2018-11-07" version="1">MPPKRSQIAPANRRAPKSFFSSAYETLTAPENASVVRSIAMFGAAVAFLASPWSSILLPPFVPFRRIWPFSAFFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LE91</accession>
    <name>A0A367LE91_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SprT-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_1279</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LE91"/>
    <dbReference type="STRING" id="1330021.A0A367LE91"/>
    <dbReference type="OrthoDB" id="5236983at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006640">
        <property type="entry name" value="SprT-like_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10263">
        <property type="entry name" value="SprT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SprT-like" evidence="2">
        <location>
            <begin position="212"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="378"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI12745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="491" mass="55446" checksum="8FDF1AE9EA601DEC" modified="2018-11-07" version="1">MAFWVLAGASTSIDDDDDDVHHGQHSRMTTTASSSSSSPPSSNGRYYMHKRGSRVLPPWGTTTTTTTTTTTTTTRGLLAFLVIREGETPSRSPSPDPPPRLISKNAEAPPGFGHGNGTASAPPRFGLERTQSGLSISSSPHDALSSLALDDNDDIATGRVLSDLEAAHLVHAHLTAFRRRCPDSQSERILRALITPKSRAADFPLDNDALCSIFSASNELFFASRLACRVAWDWSHPACGQYESHIVGTTALRRCARLGGWETLIVLSSPILRDTKYNRRLLISTFLHEMIHSFMFVTCGLKASHDGGHTQGFRQIAAIIDDWAGKDYLRLTDMEADLERFRGDSDDDIDDDTFPSRPPHHPHHHHFHHHHHHHHHQQQQQQQQQQQQQQHPPSYFPSFVRPDEGDDDNCSRLYSDFNHSESRGWPHTHHDLDRHHQRHQHQHQHHHHHQHHLHHHHHHLHDAAYSQPGGHGEWQWGEQENFGAHSPYASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LF14</accession>
    <name>A0A367LF14_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Non-homologous end-joining factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_0460</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the XRCC4-XLF family. XLF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LF14"/>
    <dbReference type="STRING" id="1330021.A0A367LF14"/>
    <dbReference type="OrthoDB" id="2155935at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032807">
        <property type="term" value="C:DNA ligase IV complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045027">
        <property type="term" value="F:DNA end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22285">
        <property type="entry name" value="HD_XLF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.210.10">
        <property type="entry name" value="DNA double-strand break repair and VJ recombination XRCC4, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052287">
        <property type="entry name" value="NHEJ_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053829">
        <property type="entry name" value="XLF-like_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015381">
        <property type="entry name" value="XLF-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038051">
        <property type="entry name" value="XRCC4-like_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32235">
        <property type="entry name" value="NON-HOMOLOGOUS END-JOINING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32235:SF1">
        <property type="entry name" value="NON-HOMOLOGOUS END-JOINING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09302">
        <property type="entry name" value="XLF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21928">
        <property type="entry name" value="XLF_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XLF-like N-terminal" evidence="9">
        <location>
            <begin position="17"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="XLF-like coiled-coil region" evidence="10">
        <location>
            <begin position="140"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="263"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="345"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="355"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="379"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="437"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI13007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="487" mass="50625" checksum="C05AF190DB918959" modified="2018-11-07" version="1">MAAADADAASAAAASAWHPLPLPASPALLVSARVAASSYVVRLTDMANVWEESLSSDGICARSTAENTSIDPSDTPENMARFLASLVSALDPLRPGHGDTSLCLTPASGRDDDGGLVLTVTCPLTGFAPLTWPIHLTKCPPSAVATHLVLPLFRSHHAGQLVIESLVQVLGYKDAVIAKMADKLEALGTGLEQVFPSLLGRSKVTRSAAGGKVKGLAPFDRAQFGLGSTEGSARLQALAGLGDGHFASEGWWRDFGKSRKHMSHDGASLPYSAKATGQDGDNEFQVQATPPGLASVAEPSGDNQAESLIPDSYPTAFAPPPTHHVPEKATSTFLGTIGGKTSTISTAQAKGSESAVDDSETASEASDDDATASAGSDACPSSSAANAATTDVKRGVIGSIGGKRVVEECPGASHDRNPSRKVGVIGGIGRSPPSKPWQEEIDRGSLKVSNDVHRETSQERADCRREEIKRDLERKAASGPAKKKRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LF39</accession>
    <name>A0A367LF39_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_1092</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LF39"/>
    <dbReference type="STRING" id="1330021.A0A367LF39"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI13030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="510" mass="58880" checksum="5C1DFEDEBD01B06C" modified="2018-11-07" version="1">MGVIYYFFVATVIIIGYCLRRPSRRLPPGPRGLPIFGNIHQISRRYSWRQFQQWHKLYGPILSFRLGQITVILLGNHEVTKELLNRRSAIYSSRPRLAVAGECIGKEFGAALLPYGPCWRLYHKIQMTFLSSSKSRLYRPLQELESRQLLFNLLSTGEYEAELYRFSSSLMFSLLYGKRFITGQEWDLKQTEELATSALQVVSFGNWIVDIFPFLNCLPHFLAKWKRVGDEFHNRRAQLYDMNVANALARPSWNWCKQSFMRDAPPVSRKELAFLLGELYETGSHTTSGALLVAVLACVCYPQAMRKVQDELEARVGPDRLPSFDDFADLHYTQSFVQEVLRWRPLAPGGVPHSPTKDDTFEEFRIPKGATVIANHWSLEMDDNVFARPNEFMPERWIKDPDLPIAAFGFGRRTCPGQHLARNSILLVVSRLLWAYDIRWKEGHARSPETIEMTHDGVFSKPSPFEATFTIRSPAREKLLRSWKDSNDDACGILNTIGDQFTRVWRRSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LF51</accession>
    <name>A0A367LF51_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DUF92 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_0993</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LF51"/>
    <dbReference type="STRING" id="1330021.A0A367LF51"/>
    <dbReference type="OrthoDB" id="30881at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002794">
        <property type="entry name" value="DUF92_TMEM19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13353">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13353:SF5">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01940">
        <property type="entry name" value="DUF92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="348"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI13041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="434" mass="46264" checksum="164004751CA8EAF5" modified="2018-11-07" version="1">MLSVISIRADGRTAVQSKVDVAFPAFLLFKLKTRFNIDNNSRFAFSVVSMKLILAAPLTAALFLRAWRRSSLTPAGIFTAVLTAIAHAYHPWNLPFLLLAVFFLAGTRVTHIKEKVKATLTQHSNGSSGGEGPRTHVQVLANSLIASILSILHSYQLRSRQAAYANADVRDPVGTTCFSWGGDVLVIGIIANYAAVAADTFSSELGILSRTQPRLITSLTLRKVPRGTNGGVTIEGLVAGVVGSMIIVMVAMIFLPTCTPETAAMPGGGVPWTVGQRRILMGFLIVWGALGSLLDSVLGGLLQRSVRDVRSGKIVEGEGGNRVLVSESSGRAAGGSVKRAEAKVAALSGLGEKPETNNETAVDDEHDTTETHENEDKHRRGSFGDDGPSRIVESGLDLLDNNDVNFLMATTMSVGGMALASWYWGLGIENVLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LF55</accession>
    <name>A0A367LF55_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_0652</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LF55"/>
    <dbReference type="STRING" id="1330021.A0A367LF55"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF305">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="124"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="148"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="345"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="254"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI13064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="448" mass="48151" checksum="35E21CBA08189920" modified="2018-11-07" version="1">MATKDEDVSSSSSPATPPDEAVDVVVNNGSKKYESSPQQQEEDDQHGRLFDGPRGWMVVAASSCSLFCYMGCIYCWGILQVEISQKTSMTLPSLTFVGSLGTSFMASISPFVGEAIRRYGYRNTALVGAFLLGLGEVLSSWVTHHLAALLVTHGCLFGIGGGMTILPCSTAPLKWFRKRRGLAVGVVFGGSSLGSTVMAVATNYLVTSVGIAWTFRILGLVLWAVCLPAALFIGPPSSQDSIPRLQWHRWTQPDFLLLLFGGAVSCFPVFVPPYFIPVFARSISHSSSTGIIALTIWNMSSTISRVVAGFMADSYLGPINSLCLAIFLCSVSALVIWPFASNMGILSVFCVVSGVGCGAFFSLFPTVTSAVFGPENTLGVLPMLWAAWFFGYFFGTPIASRLYALAAADADTTEYRPAAFYAGAASMFGLIFLVILRYRQRSVLLARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFD7</accession>
    <name>A0A367LFD7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_1133</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFD7"/>
    <dbReference type="STRING" id="1330021.A0A367LFD7"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000726">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF83">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="334"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="520"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="210"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="88"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="231"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI13135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="969" mass="110452" checksum="EC15062FE7B96C07" modified="2018-11-07" version="1">MSSDKRYPLIPMDDDDVGRQNRRHRHRDDDRRHHRDDDSHHHRHHRDDHRSTRHSRRHDPTRRSQTSRRHTEAELNSSDGPAEKKRRQNDVEERDNSAKRPRENDGGKSHENPRDEEASSRRRTAPDTTAREAAIPDLRERSRQEYLSKRETERLALLRRQVADETAELRSGVRLSDREKSEFARNREVLRLAEERLRIDDHRDAYFMPEDNMLDKPDRTNPGSASWSENAGDRLTDYQRWERDQTVKAKSQINRTDRDDDDDDDDDKYALMLDPEQYVKWSFDSKIAGEGKMLPQTKEQLLLDARIEAAETKASLIQKTRKSLPVYQYRDQFLAAMEEHQILIIVGETGSGKTTQLPQYLHEAGYTKDGLKVGCTQPRRVAAMSVAARVADELGVKVGNEVGYSIRFEECTSDKTRLKYMTDGMLLREFMVDPKLDGYSVLMIDEAHERTVHTDILLGLVKDLARERRDLKLLISSATMNAVKFSEYFEDAPIFNVPGRRYPVDIYFTQAPEANYLAAAITTTFQIHTTQGSGDILIFLTGQEEIEAAELQISETARKLGRRIKELVICPIYANLPSDMQAKVFAPTPEGARKVVLATNIAETSLTIDGIVFVIDPGYVKENKYNPATGMSNLVAVPCSRASANQRSGRAGRVGPGKCFRLFTKFSYMNEMDEAATPEIQRTDLTGVVLQLKTLGVNDILNFEYMDPPPTQALISALNQLFALQALNHQGELTKVGRQMAEFPINPMLSRAILAADAEGCVDEVLSIVSMLGEASGLFLRPKDKKIHADSARNRFTVREGGDHLSLLNIWTQWVDSEFSPLWARDNFLQQRSLTRARDVRDQLAMLCERVDVPNSTCGGSNMRPIKRAITAGFFANAARMQRTGDGYYTLKKKTGVWIHPSSVLMDAHPPAKTVLYFELVQTSKEYMRGVIPIDPAWLGELAPHFFKKDEIEALEERKMPRQRVTNQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFW1</accession>
    <name>A0A367LFW1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_0243</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LFW1"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.40:FF:000005">
        <property type="entry name" value="Autophagy protein Apg6, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.40">
        <property type="entry name" value="Autophagy protein 6/Beclin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056599">
        <property type="entry name" value="AAA_lid_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038274">
        <property type="entry name" value="Atg6/Beclin_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041691">
        <property type="entry name" value="Atg6/beclin_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040455">
        <property type="entry name" value="Atg6_BARA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF2">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23232">
        <property type="entry name" value="AAA_lid_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04111">
        <property type="entry name" value="APG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17675">
        <property type="entry name" value="APG6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="1073"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1263"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1263"/>
            <end position="1283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI13142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1315" mass="147307" checksum="2A3EB6FEC2BBE88A" modified="2018-11-07" version="1">MNCQKCRQPLRLDGSLEDLNPAAYDLLISSSSPSSPPKSKPSNQPRSSAVPPQDHARRALYDKASRSAGSPSFKRHSGGQPRDSAMSFIYLTESQVGQPQQQPNKEPPTMPSPRLRPSNSNMAKRTSDADEMERMNRLFEVLSARSDIDHPICVECTEVLVDGLQTKLDMASKERDAYVRHLRQARAEQPTQEDIKAQQEALNKAEKDRRAAMDELVRLERGNSALDEEILALEEESRQLDREEESFWRERNEFATTMAEFQAEKDSVNAKYKNDSQLLDKLQRSNVYNDTFCISHDGSFATINGLRLGRLSSKPVDWPEINAAWGHALLLLVTVAEKLSCRFQGYDPQPMGSTSKIVRHEVSSPASSRLGSRVTQPPPKKHVLELYSSGDMPLGLTFMHRKFDNAMVAFLELVRQLGVHVQKQTEPSGNPLSLPYRIEGDKIGDVSIKLGIAQDDGWTKACKLTLTCCKFLLAHASNAIRLLGMPWPLWNLYQASKAAEGEDNHDGRVLRLDDVGSIDSSTGSSTESTWTSLARPDRGFPDIVYTLKRYDGHDRLVDSRLNQATSVVGRPLNALTALVRGAPLTDADLHGSSRHSDSEQRPVLQIVTRTFQNVPRDSRSYARLLPPPPPPPGVVYPYHVRGPDDEDDVEHNDDETRSQTMIIHSEYLIHALQAVVEYDPDLVVGTPLRIPAPYRSLYHHRRQLADYRDEQPSSHSSEQVVTTARHIDILLCFLESHLGEEVQREEKRHALDQPVATFDLFWLLLKPGSVVYAKRYGVWTAYVVSGVMMPRSQSDGYSVTAWLLESDGSRLQRLDEVHSVPRWRGEHPIARLPVIPAALWPEDLDAQEGRSMRDKQTDDGRLYWELLQRPTYMQYEGMLLKAWPGEEETSQTSFMKGRVICDAAGFDRFGIEHRSLTRGWTAPPSPPPPPLPPHMVPHRRMADRLPQNAPHCGCQACGRERPRRSDDAGGPFYGFEDLDPVSDRPPEQKDSFFFLVCSKVIPGFVLGTRRWAALHVAKLKPVQPDKEAFGQLVIDEDIKRTVKALIGQFTSSRFERNRVEPWGGDDFVRNKGEGRILLLHGQPGVGKTCTAECMAELTNRPLLALTSGDLGLSASEQLVESRLNYFLGLGQRYGALVLLDEADVYLESRRPCDVSRNGLVALFLRALEYYRGVLILTTNRVRSFDRAFLSRIHVALHYGDLTDDHRRLIWSNACDRLQLHSGGRVRVSESVRSAYLVLGDANGREIRNALQTALALAEHDALSSSSSSSSSSSSSPGGQQQQQREGDEVVTLCLRHLSPVVDLARAFGEFASALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LG97</accession>
    <name>A0A367LG97_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Exoribonuclease phosphorolytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_5655</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LG97"/>
    <dbReference type="STRING" id="1330021.A0A367LG97"/>
    <dbReference type="OrthoDB" id="2504340at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF2">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT MTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="9">
        <location>
            <begin position="41"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI13446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="235" mass="25196" checksum="640D89121EB963F3" modified="2018-11-07" version="1">MTERRRVPGPNGLTTLPQYRESDDTVILSAPKQDIDGLPAVYIRTGISPSASGSAYLEIEQKYGDSQAPLSLGMKLICIVHGPRSLPRTAPFSHFTILATYSKCTPFASPGRNCPGDMTDKDLSAQLEVALRGAVINDRSPKSGVAVVVTVIESSDRSGHDLLDGCVTVATAAIVDAGIDCIDMISVGAGPMSHDIYRLPDPIARKSEEQKYRQAGYVTALPNRDEVLAIWLKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGR8</accession>
    <name>A0A367LGR8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4219 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5657</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGR8"/>
    <dbReference type="OrthoDB" id="3599317at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI13452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="25775" checksum="DDA6B313724C232C" modified="2018-11-07" version="1" fragment="single">QWGYSGHSARIDSLQRSSQRSARCTYSGHSTRLISAQGSRYIDRRAVLIAVIALDQSQIVRLIYNVKVFLQITYLPRRRFSHLLPVHHQLQLYHFFNTITSPAFNSSSILTKPLLRDSSSSSLSQIMPNTEKITFAKLSGGDNYTHWALRMDSLLIREKLQGALGSETHNKSEEALALIRLQLEDGPLTQIMHIKTASEAWNRLKELYNPVSFTSNFLLTKELLEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LH21</accession>
    <name>A0A367LH21_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_7957</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LH21"/>
    <dbReference type="STRING" id="1330021.A0A367LH21"/>
    <dbReference type="OrthoDB" id="44789at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04591">
        <property type="entry name" value="CBS_pair_voltage-gated_CLC_euk_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF6">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7 9" id="KW-0868">Chloride</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="462"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="558"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="584"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="625"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="649"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="818"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="792"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="48"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="792"/>
            <end position="810"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI13711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="921" mass="99444" checksum="0B060CBACFBDA12D" modified="2018-11-07" version="1">MTRIMSRASHTEDGSLSTTLLPSRLPRAHTADDGDELDFLGDGEDTDGGQASLLSSPSRPLHSAGDLRRNGSLQRMTAAAKDGLPLDWHTEGPGRRVGYEDLTAIDWIFEYTKERQRQRILASNAVGLMGYARRFLDASQVWIVLILTGLLVGAVAAAIDITTDWLADLKLGFCSSGPEGGQFYLNKSFCCYGYDQGSKCVGWKPWSEALGIHSTVGKWFIEYLFFVLSSVTLAYCAALLVQEYAIYAMHSGIPELKTVLGGFVMRNFLGTWTLVTKSLGLVRFPSLFSFAEARADGTEPQVLAVGSGMWLGKEGPLVHVACCCANLFIKLFDNIRDNEGEKTRKAWMMGTERLTLNSSEARSAFGGGGGRNLRRFRLPHRRRLIQSRGESRLSSSPSVRSMAFDGNERQQLSYYFPDKTMWQSFVCAMTAAVVLQAFDPFRSGNLVLYQTKYSTDWHGFEIVPYAFLGVLGGIYGGLFIKANMAVARWKKARPRFCGGPLGQVLAMALLTAVINYPNLFMKVQSSELVSNLFADCSQVLDDQIGVCKTGAASAGTTVLLVLAALLGSGLATATFGLQIPAGIILPSMAIGALTGRAAGIVMEMWVANHPAFILFSSCSPDAACITPGTYAIIGAAAALAGVTRMTVSIVVIMFELTGALTYVLPIMVAVMTSKWVGDAISSRGIYESWIHLKEYPFLDNSDETAIIPDVPASHVMTRIEDLIVLTAKGHTMASLNSILEMHPYHGFPVISDPTDAILLGYISRAELRYNVTTASRPPRSLPPESRVYFCSSSSSSSSSSTNPSSSSSPSKLDLRPWMDQTPLTLPSRTSLHLVVSYFQKLGLRYVLLSDRGALQGLLTKKDVWYVLNGAGAGDESPRAAVVGQRPEHRALLGEEGVVSAAAAAAAADGVALADDDGGSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHH1</accession>
    <name>A0A367LHH1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHH1"/>
    <dbReference type="OrthoDB" id="3557569at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF6">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="33"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="258" mass="29042" checksum="FCD5CE264E1BECE5" modified="2018-11-07" version="1">MAILMAELSRSPRLLPPKTMRPAAPPDNNSRHFHLFPLLPPELRLKIWNMNLPPWRLVPMHCDAPSPSLHEKEAPSRGDVTGFTSNAPIPVNLHVCAESRAEAMKRYRCVFDFARGPGKVIFNPDDDILLFGPRDGYMAAHSQFHTCMAMCDQAELASVRHVAISESLFWGNGPYSSRTDTSLSFEVVKQLAKCMPSLKTMLFVSVEEHVDGLEWLTDMLARQVQIAINRVRQQNPHWRPPPWHILSMDTLSKTGAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LI39</accession>
    <name>A0A367LI39_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_8071</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRN7/TAF1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI14103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LI39"/>
    <dbReference type="STRING" id="1330021.A0A367LI39"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070860">
        <property type="term" value="C:RNA polymerase I core factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001164">
        <property type="term" value="F:RNA polymerase I core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048538">
        <property type="entry name" value="Rrn7_cyclin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048540">
        <property type="entry name" value="Rrn7_cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033599">
        <property type="entry name" value="TAF1B/Rrn7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021752">
        <property type="entry name" value="TF_Rrn7_Zf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31576">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31576:SF2">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20645">
        <property type="entry name" value="Rrn7_cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20644">
        <property type="entry name" value="Rrn7_cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11781">
        <property type="entry name" value="Zn_ribbon_RRN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRN7-type" evidence="10">
        <location>
            <begin position="10"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="Rrn7/TAF1B N-terminal cyclin" evidence="11">
        <location>
            <begin position="87"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Rrn7/TAF1B C-terminal cyclin" evidence="12">
        <location>
            <begin position="262"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI14103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="548" mass="62569" checksum="6C8E0F9EAE02EAFA" modified="2018-11-07" version="1">MEDLQMLQRMPRGERCPDCGSRRWYSQDGLRFCQRGHRIEGFLEFDVEDGQLDVRPGRAIRKEKEAQKVEQRQLRGNQGKSLYLEALQLLLRNQLLWLVNTKGHCDELESVVRDLWDLRIRGSIFLAAEDEASSHDDQDNFSSQPQSEGEQQAAWVLRTRAQRWDSELGVNWPMPRLHETIALCYLGLQLLKIPTRQAQLLVWANNGEMPYKTAVSFTATLDNGWAGAHNLFKFRDLPQEMRQRMPTSYARVLQRPLCVSITGGELSRAVMNLILSYHLNYAMTFPQLRWVPLLVQYAESLALPVESIAATKRLAGLLHARFHFPVESSRILPLDHPEIHLMALLVIATKLCFPFPNNQSSIRSYLPRFNWETWMRGMSQSLQNRDSREAFRRVTPNQVVHMNDETFDAYLAHVSARWVEDGHEGENHPLTELFALSNDEPEPSLPVNVNGTHVGSGQLSSQNSGLSCEGDEDFLSQTLEPPLELTETSTQYLAYKSVESLSEVAAAFYTAAADLLGLPLELLVRAVYSQERKVLLWQERNPETTDLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LI45</accession>
    <name>A0A367LI45_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="3">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_7933</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI14080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LI45"/>
    <dbReference type="STRING" id="1330021.A0A367LI45"/>
    <dbReference type="OrthoDB" id="10248373at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.620.20:FF:000004">
        <property type="entry name" value="Ribonucleoside-diphosphate reductase subunit M2 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="entry name" value="Ribonucleotide Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030475">
        <property type="entry name" value="RNR_small_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409:SF18">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00368">
        <property type="entry name" value="RIBORED_SMALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0215">Deoxyribonucleotide synthesis</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="26"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="385"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="388"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI14080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="408" mass="46093" checksum="8E5DEB3A4C1BC3A3" modified="2018-11-07" version="1">MTAHVTPSKQAASAIESLKMESPMKKLDFGAANKENRPLDEAADVDSTSEPVSPDSGDVKKDAKLAVASTIKSEEADEPLLQENPQRFVLFPIKYSEIWAMYKQAEASFWTAEEIDLTKDMNDWNNRITDDEKYFISHILAFFAASDGIVNENLVERFSGEVQIPEARCFYGFQIMMENIHSETYSLLIDTYIREPAQRTYLFNAIETIPCIRKKAEWAIRWIQDKDSSFAQRLVAFAAVEGIFFSGAFASIFWLKKRGLMPGLTFSNELISRDEGLHTDFACLLHSHLNKRASKEVIRDIITDAVTIEQEFLTEALPCALLGMNADLMKQYIEFVADRLLVALGNDKIYKSTNPFDFMENISLGGKTNFFEKRVGDYQKAGVMASAKKTDNDAPTESKSEIAFDDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIP1</accession>
    <name>A0A367LIP1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ras-GEF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_6087</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIP1"/>
    <dbReference type="STRING" id="1330021.A0A367LIP1"/>
    <dbReference type="OrthoDB" id="546434at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00155">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF354">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="69"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="8">
        <location>
            <begin position="734"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="7">
        <location>
            <begin position="913"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="276"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="543"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="679"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1161"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="342"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="604"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="679"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="698"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1162"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1176"/>
            <end position="1189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI14298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1209" mass="131231" checksum="68C99DDDAB99778D" modified="2018-11-07" version="1">MLSDDAVRASLCVAPLDITQVQAAEAANGSSHPSQPSANLYLQYQMTPPATPNGSQEDLLPDDAVDPPVFNSYLRAYYPFEPNSAMTESSVTIALAEGDVVLVHSVHTNGWADGTLLASGARGWLPTNYCSPYEPDPMRSLLKANLIFWDLLRSASVDDNEIFKNQEFIKGIIAGVRFLLDRTGCLARESIVTHSDALRKARRALLAELSLLVRTAKRLQECQGGTLDPAEDVNDIIDEMILKAFMIVTKGVHFLDILEEERRSCVSLTSVAEDMYVPPTPPADQAHFDDAGADDAGSRDATAGPTAPGETSALQAPAAAAPWGKRLSSLQAPGPDAHGSATHGSVAQRRLSQASMRQSRRLSGSLAHRVSLAGPSPLSRPHHLASERLSRSHDKFLSYLGSFIGRLHLQSHSRPELALAVKQSATSGGELLAVIDGICEYNSANFNALGQVRAVMFERIQALVLSARDILGHTCSEEGSDIILPHDNNTLLMAATESVRAAGECVAKAKAAVERAGDFEIELPENGLDMDLSVLDAVMLERSRTPSVADEPSTSRATEHPAPRHKRPTISSVDKPLPRVPKLSIPTDRQMLVNPSPASSGPCASLTDDTASSATSSFASARTAPRYHHPSHAAAAAAAADGIQGSVPDAHHVSRFDSLAASSAGSATTYLSRVSETSIVSQTSTRATTPDHASVPRSQPSMSEMSSFSHADDADDVEARLLEKTYAHELMFNKEGQVTGGSLPALVERLTTHESTPDAAFVSTFYLTFRLFCTPVKLTEALIDRFDYVGDSPHMAIPVRLRVYNVFKGWLESHWRDRTDREALKLVIPFAEQKLGAVLSSAGRRLLELAKRVSGDRPLVPRLVSSIGKTNTAIGQYVPADTPVPHPAITKSQLHALSAFRVGANAPPILDLDPLELARQLTVRQMSIFCSILPEELLASQWMKNGGVDAPHVKAMSTLSTDLSNLVAETVLQHPEIKKRAAVIKHWVKIANHCHELHNYDGLMAIICSLNSSTISRLRKTWDAVSPKRKEMLRTLQDLVEPSQNHKVLRTRLHDHVPPCLPFLGMYLTDLTFVDIGNPATKHMSLGAGSDDAGAGGLTVVNFDKHCRTAKIIGELQRFQIPYRLLEVPDMQEWWAAQIRRVRAGDQGKAQVTYYRKSLLLEPREPAPRRDHHEPPTSATSGTAAPTRPDLFGWMSRDRGGQTPTPAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIR7</accession>
    <name>A0A367LIR7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_6200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIR7"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="78" mass="8903" checksum="A56B624101A8EA9D" modified="2018-11-07" version="1">MDAETEIDGQDDRIQGKGPYLYRSIPSVTCLTDVKERASKRTTPINTRIYNHGAYYTTTCQLGHEIFLLALVALQKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIY2</accession>
    <name>A0A367LIY2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5985</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIY2"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="82" mass="9401" checksum="BA182B7630CE8896" modified="2018-11-07" version="1">MIMSNQGVDHVIEKKKTNHVMVVLSDEVEADDSSKYFSRYFKVPTCSTLTYLYTCTCQSDRSDRSDPMTPAMTAMTRPLWPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJ16</accession>
    <name>A0A367LJ16_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Adenylate kinase</fullName>
            <ecNumber evidence="6">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-AMP transphosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">ATP:AMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate kinase cytosolic and mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Adenylate monophosphate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">ADK1</name>
        <name evidence="10" type="ORF">L249_6023</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <text evidence="6">Predominantly mitochondrial.</text>
    </comment>
    <comment type="domain">
        <text evidence="6">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the adenylate kinase family. AK2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="6"/>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJ16"/>
    <dbReference type="STRING" id="1330021.A0A367LJ16"/>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006172">
        <property type="term" value="P:ADP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000106">
        <property type="entry name" value="Adenylate kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03168">
        <property type="entry name" value="Adenylate_kinase_AK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028587">
        <property type="entry name" value="AK2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001380">
        <property type="entry name" value="PRK00279.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001381">
        <property type="entry name" value="PRK00279.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011100">
        <property type="entry name" value="PRK14527.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="9">
        <location>
            <begin position="166"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="NMPbind" evidence="6">
        <location>
            <begin position="68"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="6">
        <location>
            <begin position="165"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="48"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="95"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="124"/>
            <end position="127"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="175"/>
            <end position="176"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI14367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="270" mass="30047" checksum="66726C08AE74CDF2" modified="2018-11-07" version="1">MGFVENELKQLQNVIMSLDSRIKQLEQRATGSSHSAAEVRMILIGPPGAGKGTQASKIKERFSCCHLATGDMLRSQVAKKTPLGREAKKIMDQGGLVSDDIVIGMIKEELDNNKECRGGFILDGFPRTVPQAEGLDRMLKERNQKLQHAVELQIDDSLLVARITGRLVHPASGRSYHSSFNPPRQPMKDDITGEPLIQRSDDTVEALKKRLTTYHKQTAPVVEYYRQTGIWQGLDASQQPGQVWNSVLNILDGNKKSQSLGFWNRITGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJ73</accession>
    <name>A0A367LJ73_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_6163</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJ73"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="67" mass="7653" checksum="CEEB026E8660303D" modified="2018-11-07" version="1">MGAFVDYNVVVFSMSLHVYGLETTIMYEYTHPIRYYHTATAQEMEASNPYFSKDSFDPLLPHGPVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJA0</accession>
    <name>A0A367LJA0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_6096</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJA0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="105" mass="11737" checksum="839C72C436448A2A" modified="2018-11-07" version="1">MWSIKGLAKAQFLDKGLEFSAVCHHFGRLDPLNPSCRQQSLLPKKGDPLKTAIDPFPYSGLATHFLGRFERQMPLPIFQLDAVQTLYHTSSRAGGHSSVRTKDNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LK72</accession>
    <name>A0A367LK72_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">proteasome endopeptidase complex</fullName>
            <ecNumber evidence="3">3.4.25.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_6390</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.25.1" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LK72"/>
    <dbReference type="STRING" id="1330021.A0A367LK72"/>
    <dbReference type="OrthoDB" id="429533at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03763">
        <property type="entry name" value="proteasome_beta_type_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000005">
        <property type="entry name" value="Proteasome subunit beta type-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024689">
        <property type="entry name" value="Proteasome_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF4">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12465">
        <property type="entry name" value="Pr_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0888">Threonine protease</keyword>
    <feature type="domain" description="Proteasome beta subunit C-terminal" evidence="12">
        <location>
            <begin position="221"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI14821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="271" mass="29194" checksum="23D11F76C1E7B9F9" modified="2018-11-07" version="1">MPGFDFSNYNRNAALHARGLPLPKATSTGTTIVGCIFDGGVVIAADTRATSGPIVADKNCEKLHYISPQIWCAGAGTAADTEFTTSLISSQLELHSLSTGRKPRVVTCMTLLKQHLFRYQGYIGAYLVVAGCDPTGTHLFTVHAHGSTDKLPYVTMGSGSLAAMSVFETRWKAKLTRDDAVKLASDAILAGIFNDLGSGSNVDVAVITNEKTTLMRNFIKPNEKSAKLQSYAFPKGTTAVLNEKIIKKSEMSRYVSVQEVPLEGERMDVDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LL20</accession>
    <name>A0A367LL20_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LL20"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="145" mass="15538" checksum="F2B08AA8E89785D5" modified="2018-11-07" version="1" fragment="single">GLPAFQRPAYRESIIAKAASRTRSSPSAADSTRPSSTLTRPGRTAPGSAAPDHCMTVVDHNYTTTDLAALYTVGCRVNFIWQRFESTSAGRRPWPTDAQHARLLDALARANTFQASWLTSSKVIYLSASVCGSGIQIALAGTQKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLU6</accession>
    <name>A0A367LLU6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U three protein 23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_6751</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in rRNA-processing and ribosome biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UTP23/FCF1 family. UTP23 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLU6"/>
    <dbReference type="STRING" id="1330021.A0A367LLU6"/>
    <dbReference type="OrthoDB" id="25675at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09865">
        <property type="entry name" value="PIN_ScUtp23p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000118">
        <property type="entry name" value="Phosphatase 2C-like domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000006">
        <property type="entry name" value="rRNA-processing protein UTP23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057776">
        <property type="entry name" value="UTP23_sensor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24779">
        <property type="entry name" value="UTP23_sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="UTP23 sensor motif region" evidence="9">
        <location>
            <begin position="631"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="597"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="600"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="614"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="646"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00076388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI15370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="670" mass="75035" checksum="A3333B3348293723" modified="2018-11-07" version="1">MRGMRATRLPVTVVIPTTFLSTPSQLFNPIRRRSASSTSSPTERRRRPPQLPFRFETGIALFAKRAPRPFPPPFLSPPSASFSDPLSTHHQSRNRRGYVNGELLRGLTNGDDAVYVSDFFVCANDGVGAWATRPRGHAGLWSRLILHFWAAAIEEERATTLSSEAPRDPHPVATLQAAYQKTLDATVPHDWQGTTTTCGAQLHYRTHKDADEPSPLLYVTNLGDSRVMVVRPRTRDVVYKTTEQWHWFDCPRQLGTNSPDTPEANAVTDVVELEVGDVILAISDGVVDNLWEHEIVESVVTSIAHWESAEDQPSPMDRTGGRNGGMNTLAEDLMKAARIVAVDPFAESPFMERAIEEGLASEGAGHGIITCREERYHTCHGKFITAISSAFSNITSECDSLVCLSQLAASVKMRGKRSKQYRKLMEQFSMTFGFREPYQVLVDAEMVFDTCRCKMDLEPALQRTVHGKVKPMITQCEIRKLYARKDEPGVSDVIDAAKSFERRRCGHHPDEYPEPLSTMDCMRSVIDAKDKGDNKHRYVVASQSQEVRRMLRGIRGVPLIYVRRSVMILEPMSDESALTRARDEKSKFRAEIKATLGKRKREEVSDGDRDDTGHSTIKQNEATSEMAEKKKKKKRGPKGPNPLSVKKSKKPQAKARKQEDVKMTAGDDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLY3</accession>
    <name>A0A367LLY3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine aminopeptidase S33 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_7030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLY3"/>
    <dbReference type="STRING" id="1330021.A0A367LLY3"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050228">
        <property type="entry name" value="Carboxylesterase_BioH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194">
        <property type="entry name" value="HYDROLASE ALPHA/BETA FOLD FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43194:SF2">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN LPX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="3">
        <location>
            <begin position="99"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI15410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="391" mass="43072" checksum="CB5189D89EBCC5F3" modified="2018-11-07" version="1">MENLIRPTTAVIAAASLLLVVVAAQRRKRQILLGPSRSIISQDKHHPHHHHHHHHHHQQQQPQPQQLIYLPDSLPGARDVETPYGSVRVYEFGPDDGEKVLLVHGITTPCLPLAPLAQALVERGCRVMLFDLFGRGYSDGVGDLPHDARLYVSQMLCVLASSPLPWTGRDAFRLIGYSMGGAIAIHFAISFPHLVSSLVLLAPAGLIRFDRRTSAIRLVISAGALPQFLLATVAAFRLRSPLTSPPPVSRTAVAVAAAEAEVTSPDSAKHAPLEDRISDYVRWQVENHPGFVPAFLSCIHAAPLTNQHESWRRLAERPPGSTAVFLAEDDELISPAVYAREGLPLVGGHERVVWKVLPGTHDFIMTHVGRILDELDTLWHMKKSAWEDIGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LM96</accession>
    <name>A0A367LM96_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">L249_3546</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LM96"/>
    <dbReference type="STRING" id="1330021.A0A367LM96"/>
    <dbReference type="OrthoDB" id="3065412at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051735">
        <property type="entry name" value="CFEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928:SF2">
        <property type="entry name" value="GPI ANCHORED CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G10580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016688725" description="CFEM domain-containing protein" evidence="17">
        <location>
            <begin position="17"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="18">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="42"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="51"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RCI15507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="153" mass="15152" checksum="848EE39EB0319EAB" modified="2018-11-07" version="1">MKSSLLFTLAAGLVAAQDLNGLPPCAKDCVTKNMSGSGVGGCPSADIGCICKNKDFLNNIACCLAKACKPEDQTKTIGFAKQLCNAAGVQVPEKVECADKDKAAAAASSTTRASSSSSSATAASTASSSAAGPALAAPGFWVGSLMMMLPAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LML3</accession>
    <name>A0A367LML3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LML3"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="106" mass="11532" checksum="C126FCE84EED0DAE" modified="2018-11-07" version="1" fragment="single">MEEVDRGHLRGYRRDSDTSAGGSADVDGSAPRRVPGRVARAKQNLHRSSYLHIHQRSSVIQCRSSFSGVSPPLALLSPPNGYFVLPFYPFSCSSSSSSSSSPIFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LN40</accession>
    <name>A0A367LN40_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_3169</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LN40"/>
    <dbReference type="STRING" id="1330021.A0A367LN40"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI15854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="515" mass="58448" checksum="2690C3DA5D9B1EE2" modified="2018-11-07" version="1">MFSLQLAYAILVIGTAIFGLFLWSLLQSPLRKVPNAHWTCGISSLWILWARYHNRELALLAEKHQRLGPIVRVGPADLSVSCYDDGIRTIYNGGFEKPAYYDFFLYYAQKNAFCSLSRADHSLRRRRIAPVYTKSALFASESLSTLTHSILYERLVLIIRRDAVSDKATDILSLSYALSLDLLTCFQFGLASGSNFLQAPPASLQTWMEHYEKRYCKLAAFWPQELPRLTLFLQSLGIDMVPESQRLSTKFLEDWLLGLCDRAEAIRLAKDRGVEVHPADVPVVYEILKDKVDTEMPGEKKMEIASELFDEMCLVLAYTIYYISRDSSAQRQLRAELETLDPNMRIPSDGLASGNRLPSPSSLDNLPYLTAILNESLRLRPTSTPLPRITPRDRAVSLAGTDGIPPGTRVNTFQWFIHRDPRNYSDVDEWRPERWTEPASKNGKSPMLWAFGGGSRMCVGASLSYYLSDIAIVMRYILAIIYTNFTSEVVAKRMGTHEPGSKEDEILVQFRKIMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNB2</accession>
    <name>A0A367LNB2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial</fullName>
            <ecNumber evidence="4">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Succinyl-CoA synthetase subunit alpha</fullName>
            <shortName evidence="4">SCS-alpha</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_1893</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>succinate + ATP + CoA = succinyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="4"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNB2"/>
    <dbReference type="STRING" id="1330021.A0A367LNB2"/>
    <dbReference type="OrthoDB" id="1664372at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009361">
        <property type="term" value="C:succinate-CoA ligase complex (ADP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004776">
        <property type="term" value="F:succinate-CoA ligase (GDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000005">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01988">
        <property type="entry name" value="Succ_CoA_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005810">
        <property type="entry name" value="CoA_lig_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004230">
        <property type="entry name" value="PRK05678.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01019">
        <property type="entry name" value="sucCoAalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117:SF2">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP_GDP-FORMING] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117">
        <property type="entry name" value="SUCCINYL-COA LIGASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01798">
        <property type="entry name" value="SCOASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="CoA-binding" evidence="6">
        <location>
            <begin position="40"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="4">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="52"/>
            <end position="55"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="144"/>
            <end position="146"/>
        </location>
        <ligand>
            <name>CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit beta</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI15900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="357" mass="37215" checksum="22EE200F26AE68E3" modified="2018-11-07" version="1">MLSLSRTAALRPAAVLRQVSRRAYSSSTSPYAKTVDNLRINGETKVIYQGFTGKQGTFHAEQAIEYGSLVRADFGLGALGTKVVGGTNPKKAGQTHLGLPVFKNVSEAVKETGATATAIFVPPPLAAAGIEEALEAEIPLVVCITEGIPQHGKFSWNAQGLHMVRITSMLKSQSKTRLVGPNCPGIIAPGQCKIGIMPGFIHKRGRIGIVSRSGTLTYEAVNQTTQAGLGQSLVVGIGGDPFSGTNFIDCLKVFTQDKETEGIIMIGEIGGSAEEDASEFLKEANTVGGGKPVVSFIAGISAPPGRRMGHAGAIVSGGKGGADSKIKALESAGVIVERSPASLGKALYDEFVRRDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNS9</accession>
    <name>A0A367LNS9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_1839</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNS9"/>
    <dbReference type="STRING" id="1330021.A0A367LNS9"/>
    <dbReference type="OrthoDB" id="4738875at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI16088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="206" mass="22304" checksum="B24EC2E011C5B9A3" modified="2018-11-07" version="1">MKNKNSNKTSIRPATMADVPAMSSLVCTSLAEEAAWKRLCPPKQEVESLLAEAMTNRRKHVMVLEDDTNGVVVSASVWEEADEQRHPSTAALSSCTTADDDKDDKAACLALRLLATRPDCQRRGYGRALASWGVRRAGKRSVPVCVLAAERGYILFSGMGFVDRGLVSLGGGGADDDEDGDVCVKTMVLQPLPSRRLRVAKLLSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNT0</accession>
    <name>A0A367LNT0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Orotidine 5'-phosphate decarboxylase</fullName>
            <ecNumber evidence="3">4.1.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">OMP decarboxylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Uridine 5'-monophosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_2336</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OMP decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.23" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNT0"/>
    <dbReference type="STRING" id="1330021.A0A367LNT0"/>
    <dbReference type="OrthoDB" id="10263753at2759"/>
    <dbReference type="UniPathway" id="UPA00070">
        <property type="reaction ID" value="UER00120"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004590">
        <property type="term" value="F:orotidine-5'-phosphate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04725">
        <property type="entry name" value="OMP_decarboxylase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014732">
        <property type="entry name" value="OMPdecase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018089">
        <property type="entry name" value="OMPdecase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001754">
        <property type="entry name" value="OMPdeCOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32119">
        <property type="entry name" value="OROTIDINE 5'-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32119:SF2">
        <property type="entry name" value="OROTIDINE 5'-PHOSPHATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00215">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00934">
        <property type="entry name" value="OMPdecase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00156">
        <property type="entry name" value="OMPDECASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orotidine 5'-phosphate decarboxylase" evidence="12">
        <location>
            <begin position="36"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="10">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="10">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="active site" description="For OMPdecase activity" evidence="10">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR614732-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR614732-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI16093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="353" mass="38480" checksum="4B7AE781E51B142E" modified="2018-11-07" version="1">MSSHPSLKATYDARADAATHPLARHLLRLMGLKASNLCLSADVSTARELVYIADKVGPSIVVLKTHHDMVSGWDFHPQTGTGAKLASLARKHGFLIFEDRKFGDIGNTVEMQYTAGSARIIEWAHITNVNMVPGKASVASLAKAAERWVDRYHYEVRTSVTVGTPTADDLEDNAGEEEPVRRKGSIVSVTTVTQQYEPANSPRLAKNMAAGDEVVFPGIEEAPINRGLLILAQMSSEGNFMNADYTGACVEAAREHRDFVMGFVSQESLNSEPDDDFIHMTPGCQLPPHDEDPNGALQGDGKGQQYKTPHNIIGLCGADIIIVGRGILKAGDPQDEAERYRSAAWKAYLERVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNU0</accession>
    <name>A0A367LNU0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_1768</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNU0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI15912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="206" mass="23419" checksum="01F056E7AEE44F15" modified="2018-11-07" version="1">MSHAGWNASLRPAPWKRTREIFFIPSGSSGWLENDNKCLPRNGQKHRGLFQKDSARKVERWNAGMGWGYAAWAYMQNLTTTSHFPPTETPRFNPSLAKFVDRVRAGMRSRLITMVIDDPRQRGGLYDFINKLDCLKPLLTNKHPMQGSANCPRRGQMPAYLQRVIHIAVFPTVFMPYLGLDAFFSPLPVTSPALSALPNRERSMVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNW7</accession>
    <name>A0A367LNW7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UDENN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_2385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNW7"/>
    <dbReference type="OrthoDB" id="6019893at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032483">
        <property type="term" value="P:regulation of Rab protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001194">
        <property type="entry name" value="cDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005112">
        <property type="entry name" value="dDENN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043153">
        <property type="entry name" value="DENN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051696">
        <property type="entry name" value="DENN_Domain_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037516">
        <property type="entry name" value="Tripartite_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005113">
        <property type="entry name" value="uDENN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296:SF21">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12296">
        <property type="entry name" value="DENN DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03455">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02141">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03456">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00801">
        <property type="entry name" value="dDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00799">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00800">
        <property type="entry name" value="uDENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50211">
        <property type="entry name" value="DENN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN" evidence="2">
        <location>
            <begin position="209"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="679"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="844"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="696"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="846"/>
            <end position="873"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI16110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1125" mass="123378" checksum="FE773E96E624CF9A" modified="2018-11-07" version="1">MDDSSTPLADYFWIAGVESVSYDGSQLSIREHGGDLRAPARHSRQSSANRLSKTSTVDARFSISTLDELDGNTRSNRSSATIKPSVAARCPAAEPQPPQLGDFDFDSALIKFAAERENFLEDLSFSAGAKTQSRPPMVNPRAERIRADDASSGRVSPLRSIKGSIRRKISFRDMNSVRKQPGSSRQASSTRAASIRTARRLSNYNSVIPPPEPLNTDPDMHPLKRRFEPVLLDRYPPKTATDDVAKRGRFPDYVPMFAFPNDIQIVSSDDRPRSTWHGFTMTSDDNSRLYGITIIIWTALTADVADDIETKCEQWRQSHMSNEERELAASLGVRLAAERSHLSHLLSKLPTIPSGSSARERLEDEIGTVEEKIALMTDMLRPLRHGAASKIEGLTAGESGLWIPRAYGILGRDAANMAFWKEWLKTILIPMADGCVLRVPPSSPKVGRWQPLERYVVNLCTEAFSPLGSKTQVELGVRELRLYARKEAANELPGSRTVDLYALFRCLSLENVVALFEYAMTESRIIFLSSHTSMLHLACHALACLLYPFTWASIFIPVLPARLISALEAPCPYIVGVERRYESIDLPDDDYVLVDLDRDTIDATSQPHRLPRPHRRKLMSLLQVAAPHTLRYGVSVGPPPYAIESFPYDSFSSENASVFSSTPPPATLAKWVSQSSSSFAEADAADQMQPPPRPGTSKSSRTSPQSSVSPASTNFPPMPTTPLSRSDSGFALTVTLREKRSGHFGEDKGRRSSSFGLDKFHPAHRAGVSLLNGHQPNASISGISVDSHSSFGCGGGVGYAPSTYAQSTLAASTIMPNMQVQPVRNTETTVWVEGHCFRLGNPDDACSSSTSTASATTTTTSSTSTSSSPSSPCSICDERSDGDGVYICAVCKTVAHGRCLGQVSLVCPEAFRPDRVRAAFVRCMASLLYTYRKHLGRPSKQQKSNGQLYAFDMDAFIKGLPYEQQEYAAMLRDTQSFNEFIGHRETTAATDPSIRLFDEIIMAKKFRGRPGLPSGLSRLSTIRASHGAPTNAWNLSAPSRGPGSKAPPYLTDATDHIWRTASVPLPKGNFPGEYRSVVTRIPHRLDRALMREPRSIQGVPRAEQRGARGLVRKQVPSILGTTPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNY3</accession>
    <name>A0A367LNY3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNY3"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="84" mass="9810" checksum="6A12DD63FDC6B470" modified="2018-11-07" version="1">MFGFCLALLARRLLRRDDVIVKQLLFLEDQPWMNMAKSTDRGSCWRDLRLIARDRLSRLRSFKGGKTGGEERKRKMDGAILHST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LP69</accession>
    <name>A0A367LP69_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LP69"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="282" mass="32010" checksum="886781C78EB78C38" modified="2018-11-07" version="1">MYKKGKTPTTTLLPFPRPTREDTPSSSWKKGEGEGGIVPKSLPTNCQSLSPPSLAFNRSETLYTFGITNQSISTVKSIRVEGSGSENPDDGDAWLPESHARCSNRKKAYSCSRDTQDERGGGSFLSPAPLEDLYFISFLLFSFIPRKEESDRKKKKKKKKKRKRPSTKALMSRSYPTWNIDCFSAFRDKCGKRRRGFFSPYSRRPEDSFHPPSDTHTRHDKTRQTKASSYEYRTGIYEKKKKKTIIISSAIAAPKEAIGYADQSRCDCRSTPPFRIFPCLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPB0</accession>
    <name>A0A367LPB0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Disease resistance R13L4/SHOC-2-like LRR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_2179</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPB0"/>
    <dbReference type="STRING" id="1330021.A0A367LPB0"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019487">
        <property type="entry name" value="RAM_signalling_pathway_SOG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10428">
        <property type="entry name" value="SOG2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="4">
        <location>
            <begin position="157"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="318"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="616"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="672"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="926"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="618"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="672"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="934"/>
            <end position="947"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI16273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="964" mass="105178" checksum="9FF17380A74176A8" modified="2018-11-07" version="1">MERPDRMPGSATHPSGVRGLPDNPAQGRRAVPVPPYPISSNGHPPPPPPPPPPPAQPRKVSSNANATLSATKTTTPAQVIALARQAMQTALESEKNQAADVDAVGPGLRSGVTIDLSRKDIQKLPEEAVDIVKNELERLALSHNQLSSLPARFSECTLLRYLNIRGNQIKEFPMPLCDLKSLEILDLGRNQLRSLPNELSKLSSLKVLSVPKNQIRELPVCLADMGSLQVLKFEGNPISFPPKDALRPQNGSPPNDGVQREHEVNEVTMTAHIKKYMKQYAIHGRMDPEATGDESSEGAETPRFPLKRATSGRFPIKVNGADVPDIRSPNSGSRPPAVPMRAHSRGLSQQNAAIRRPSVMPLTIGSVNERLRSNSETLLRSERPDGRNRRLGLVSKKASELGTLDETQANVRFSHYRGLSHGSAMQGAPPRAKSPATPTEPSLQRPIYVRRLSVLPERRRESKIFDPVIEAAKGILYSVFQIHPMIQMLMTLTNNGSTKRSSLEIVFYNTNSHVEELEQEIQKHDTADDDVTPHDNGNVRSACLTLVSAYGHVCTQMAENIDTFVDDGDARYIRTLLMLIYNSIMELRVTLASTMAEHVKARPANWQPENVGRTIRPYHREPTTTPKGDRPGFARSRNGTVVHNPANLRVATDVALPYVNGSGQSVMITSATPRSGESFSSVHSRETGSDFSDDDAQFDRIFLSLQRSADLALRTLPGFQEQLAGGLRNAAQQRAPAAMIQDRKSLIAMCNTTVQQTEILRNRLSLVKLKDPGVRTQPSFWNQCNNFVASWTNMAHKMKAAHNTIPLPPDTRLRLRPIQQSMKETSSTIMQSPWHHLFRPSGVPAGAYASQVTSPTRTQVPITPLSAALGPAMQATVPTTPHGNAFAAAFHGNVFDRADALMANPGISMARNGAMQRGHSGFPSLSSISSMSSDGNTPASSATFSPNNSLGLLPPRINGGKVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPF6</accession>
    <name>A0A367LPF6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_3206</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPF6"/>
    <dbReference type="STRING" id="1330021.A0A367LPF6"/>
    <dbReference type="OrthoDB" id="6058203at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01446">
        <property type="entry name" value="DSP_MapKP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18533">
        <property type="entry name" value="PTP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF561">
        <property type="entry name" value="PROTEIN TYROSINE PHOSPHATASE 36E, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="6">
        <location>
            <begin position="309"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="4">
        <location>
            <begin position="556"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="5">
        <location>
            <begin position="789"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="157"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="194"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="212"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI16325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="939" mass="102823" checksum="4ECA5DA5A82AC8DA" modified="2018-11-07" version="1">MPIAMHDSRFADRTPVHYTMKTHPRPAAGGPVCHAVAHPPPRASKSTKPTPTTTTPQASPRAPYSVGQNTPPVLSPARHHDARASSPNYFGLVVESSTDPRESSGLGRDNWSPASSSIKSFAAALPKQLPLEPNPEFEAFRRQADINWSMSFTLSAAPNSKTTSVRSRPPRLPTPASDGHPTNTSSVAPPVNASRDRLTTKMDVDHDPEVGSQGSTRPSIIPTQITSMPVSDSPMMMDSPRHPPKPLRPPTAPARTDGRLSMTVDPPAPMSSGAAEAGGRAITLPPKLDAGGPSMISDARLKELMETIDNDRLLLLDIRSLQSYAHSRIRGALNLCIPTTLLKRPNFNIEKLKQTFQGGSESTKFADWRRMLWIIVYDAHAWESREAVTAQNMIKKFTKEGFTGETAILRGGFSIFHKSFPRLIDDGSANPPPARGGRSGRVNAGLAPVIGGVNLPASTGEVDPFFSNIRQNVDLADGVGQMEVTRPPGLDSPLLPLWLREAASTSDRGRRVADKFLRIELDEQARMRSAYAAFKPGARGQEQSKIQLSGVEKGGKNRYKDILPFEHARVRLQDKPDGSCDYVNASHLGTSRSHKRYIASQGPLPATFEDFWSVVWEQDVRVIVMLTAESEGGQLKCHTYWKGREFGAIKLRLVSEKKASLDMDKHRDDACATCSAAEFGRKRANTTTTLEATATAGCAGCQGGQGQTEAPYVVIRKFVLAHAAHPFAPMREITHLHFPAWPDFGTPAKPSHLLALVELANLMQRAARPIETTSLFGAGRSAADDHVPASWYDEPENDSQTRPMLVHCSAGCGRTGTFCAVDSVIDMLKRQRQAKLAAMRGADEDDEPISPRSSGIGAVAASGRQTAHASEADWVRDETQDLIETTVHEFREQRLSMVQSLRQYVLCYETMLEWTHRMNERSANMRLRSGSLKQSRRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPH5</accession>
    <name>A0A367LPH5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine/threonine-protein kinase ppk6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPH5"/>
    <dbReference type="STRING" id="1330021.A0A367LPH5"/>
    <dbReference type="OrthoDB" id="5420391at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42084:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PPK6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42084">
        <property type="entry name" value="YALI0E26631P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="468" mass="50796" checksum="EEFC2526E32FA4F9" modified="2018-11-07" version="1">MSADLFAEFSKPSKSTGQEREAAAAPDDDDGWGDFETAEPVITPAVKQPPPARTVVNNGIGKRPPLILDTTRPKAQAKAALASPHVLFDVDDFELQTGDIIDDDDDFGDFTSAPQSCINTTATPSLDLLALEESPASHQSARQETTGKKPSFGAPLPARSSNSSKQKPSSALDLLNDMSGATSFNLASNSNLLTSSAATEVIQTTVEDGDGDWAAWDDHPAPAPSAGPATVREQSPDGWAWDAEDSGKPLAEDSSNKPPPTNVPPPWVILSTFPELFSSGTPIFKSLMGQSVSVQEQILMKPKAVQFLQCYILLATTAARVLAGRKHRWQRDKMLAKGMSLSAVGSKGMKLTGVDKTQTSREDREAAEVVASWREHVGRLRAAVATANSCNETKLKMPELSNKMQIHTAKMVPTAPTACVICGLKRDERIVKVDFEVEDSFGEWWVDHWGHRACKNFWLEHEPRLRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPI5</accession>
    <name>A0A367LPI5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_2150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPI5"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI16338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="126" mass="13590" checksum="C0FA28CF23D5DCEF" modified="2018-11-07" version="1">MLDGAPGFTSRPEANAKDDLQGIIPMSSIQSQVIQVGHPGHISCLVLQGQDREAGRRCGEEEGEGGGDEGLMLMMIMTTMAMKERICLGATITFTHRVSVGDKLLEVADPDPLFHRSGTARRTVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPP0</accession>
    <name>A0A367LPP0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1761-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPP0"/>
    <dbReference type="OrthoDB" id="2344991at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013879">
        <property type="entry name" value="DUF1761"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40638">
        <property type="entry name" value="UPF0591 MEMBRANE PROTEIN C15E1.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40638:SF1">
        <property type="entry name" value="UPF0591 MEMBRANE PROTEIN C15E1.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08570">
        <property type="entry name" value="DUF1761"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="146" mass="15310" checksum="EF66B80094F342A9" modified="2018-11-07" version="1" fragment="single">NLPPVKPSAIAVGLAFSQSVELAVLAPVFGQTYQRAKQSNTKDEFLRSREAAGAAAAWGTSFVGAAMQAYGVAALINATGTLSYKGAAYLGGLIFTATAVPTYLAQLFTEKRPLDTVGVSVAAKLCETVGLSMMLTWWGTRTNPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPQ2</accession>
    <name>A0A367LPQ2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_2604</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPQ2"/>
    <dbReference type="STRING" id="1330021.A0A367LPQ2"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="257"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="366"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="80"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="290"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="387"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI16389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="478" mass="52710" checksum="49095443C05EBABC" modified="2018-11-07" version="1">MSAAPAEARAQAIVVGEEVDDSLSQATLPSTEVPASPAVIPSSLTPPSTQAPVARPPPPPFVAPKALELPAPEDVMTASVERLRALVQSLVAEIEKLRQDAAKDQMQFHFLSLRSEDDSKRAAVEYEMVLRELDALSQAEMSRQADRELSAASDARYLQLKKEYDDVVNENRVLSRRLRAGKKLIRCKLEDNVSLTEVNELLVTRIRENREHLNILRSPGGIFHTPRPQLPPTPRQRVVPLHRPEAADCSLSALLQAANQHHHHSASSTPKSSHQNLQRPAAAVARHNRNAQSMSSLPTTPRSRIHDPTLLPPVELVPQTEPARYRQRRRESTISAGDNEELARQAVESAAAAAAAAAAATAAATAATRSMASQVDQRRRRRRRRDDEEDDDDDDDDDDDDDDDDDDDDDGHQIVDSRASQAATELLRRQSFNPDTSARLQSRLLSNTPVSNKRDQGSPAKKMRTEERSVGLGIQFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPR3</accession>
    <name>A0A367LPR3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ABC transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_2862</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LPR3"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000967">
        <property type="entry name" value="ABC multidrug transporter mdr4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000057">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="730"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="779"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="844"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="875"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="961"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="36"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="369"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="734"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1075"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="654"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="667"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI16400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1351" mass="145168" checksum="CBF9A8D2FB28FF6D" modified="2018-11-07" version="1">MASPGRTSKRSLAVVVGFFRLLTAADPLPLDYVLLFVATFGSILAGLPFPVMFIVFGELLDQVNTASCSEGPVSESYYQSLSTKVLLTVCVAVANFVSIYVSAGAWSLFGERLVRRLRYNYLRILLRQDISFFESLSAGDVAARLDSDLLTIQTGVSEKVGIVIQSVSYFIAAYSVSFVKDAKLAAMLISLVPAFFFMTFIGTHLSGKYRNAVEKNLEPANALASESLANIRLVKALHAGKRIQTTFQDHLDAARRPAIAKLATAATQMGLLHFIAYSANALAFSQGARHIADAKEMGDTSVTAGAVYTVMVTLIDASYILSQVAPFLNMFGAASQAAAQILTTIERKPAIDASPDAPGLLIPAIEGRVDLKNVSFRYPSRPGTLILDNFNMSIHAGETTAIVGLSGSGKSTVASLVQRFYDPQEGTVTVDGHDVRNVNIHSLRGHVGYVEQNPMLFDRSIMENIAHGLVGSYWSEHQSVRLSLINGDLSDLTEAVRLGGDLDRLAARSSTLSRILSLVQTAATQAGCDGFLDSFPSGLATSVGPAGSRLSGGQRQRIALARALIRNPAILILDEATAALDSATEAQIQDTIANLPGKRTILCIAHRLSTVRDAHSIFVTGPGGRIVEQGNYEELMNGGGVFASMVRSQAIPGHEAGLSDCDDEDSEKTMTRPSDDSQKRDDVASETLSAANDGKLPVRSDLGPPSDGAEAEKSYWVTLKLVVEMIRPQLLVVVVGFLCSVIIGGSHAGDAVIFGNGVGHLSVCRTASQVRQSGSLYGLLYFILALVEFFAHAVSVVCFGWVSEQLIHQLRSLTLQSLLERRVRWHESDGRTPGNLMSLLSADAAAMSGLTGTILGACVSVLVTLVAGIVLAHVVAWKVAVVLTACVPLIFCAGFLRIRLYAKFAERHAKAFAESVSTATESVNHIRTVSAFALQDEVTNSFDRALEGPYKATLRSITFGTVWLAAAFSIGSLVKALAFYWGGRLIAQREITQTSLFITLVSLLSAAQLSGQMFSLSPDISKAAVAGRRVFGLISPNNLRDEKKVMDVEKRAMGGSRRRQRQWLGSTRRDVGMSVSLQGVWFSYPNRPEQNALRDVSLDIAAGAFVALVGASGAGKSTILSLIQRIYRPDTGIIKLDGCDITRQDKDKGNDDFDDDEALSIWDDVALVPQDATLFSGSVGFNISLGGRGTRTVSTAEMKEAARLANIDETISRLPQGYDTACGPTGSQLLSGGQKQRLCIARALVRRPRLLLLDEPSSAMDAESEALWEKSLKGMVQAGVTVICIAHRLRTIMKADRIFVMDGGRIVDAGSHGELARRCERYRDGVMHQTLEVDCRLTGNALRAGSAVVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPU8</accession>
    <name>A0A367LPU8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_3129</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPU8"/>
    <dbReference type="STRING" id="1330021.A0A367LPU8"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G02870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639:SF1">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI16421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="267" mass="28786" checksum="B7E0EA5885D06C7D" modified="2018-11-07" version="1">MQGTREIELQDHAIYPSLRGKTVLISGGAQGIGASAVELFCRQGSHVVFLDQAETEARVLCDRLREVESFSTPDFLFCDMTDLDQVALCARDTVERLGRVDVLVNNAGSAGRFTTAEVTAASFDEDVNVNLRHQFFLTQAVVPCMRRRGRGCIINLGSISWRIPSTGTPIYAAVKAAVVGLTRTHAREFGVDGIRVNSIMPGAIATRKQVETVLTDEYRAECMAGQCLKRVLLPGEVASLMLFLASDDAGAITGGSYVVDGGWVGDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQ29</accession>
    <name>A0A367LQ29_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bud22 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_2643</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQ29"/>
    <dbReference type="STRING" id="1330021.A0A367LQ29"/>
    <dbReference type="OrthoDB" id="3364872at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037393">
        <property type="entry name" value="Bud22/SRFB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015158">
        <property type="entry name" value="Bud22_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23325">
        <property type="entry name" value="SERUM RESPONSE FACTOR-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23325:SF1">
        <property type="entry name" value="SERUM RESPONSE FACTOR-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09073">
        <property type="entry name" value="BUD22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bud22" evidence="3">
        <location>
            <begin position="18"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="149"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="149"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="248"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="378"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI16528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="422" mass="46056" checksum="BB1AAAC7E73A65FF" modified="2018-11-07" version="1">MPKRKRSVESSVQAAFAKHEVEIFRALKAAKGFERQRLSKRLHEDRVLADKKRRLEREITVLKSLDLHQTARVHLTSSLLRVKSVAASSDFPEALRAGVSKSQIPQEERVALHNVTSGLYNRDNVKQATDRAVADVCGLLDVTATDKVKRSRKNEVADARPDSGLETWEEKSELDGFESDVDEPGPAVGGMDSDDEAVEGTELAKYDDALGSSDEDDPVRDPRLQGFGNNISLSASPSDADMELDANSAPSRSPLSPPAKSKTSKGKPSAAIKLLPTSLPSLMGGYISGSESASDVDEAKPKPRRGQRARQAIWEKKYGSSAKHLNKPSGKDERDAGWDMRRGAVAENDRNRKTPWKGGAVRGSLVKNGGNRTVAARTDARERPHHKPAADDGPLHPSWAAKKKARDTQRSTAFSGQKMVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LR27</accession>
    <name>A0A367LR27_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_2969</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LR27"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI16682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="125" mass="14194" checksum="45396E6374868E58" modified="2018-11-07" version="1">MNQPLFVFFFPPRADQEHHGGLKPFFFPITWSYLFTTYVAQPRKKKEELVAQHTDGRARKQLRIINLLLLDRTCLKEREASTSSEGATQVQTLPSGTIGSNMYRCTLGDRSGIQEVSSHEPVAIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LR63</accession>
    <name>A0A367LR63_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_2984</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LR63"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI16935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="120" mass="13510" checksum="EAB8C1114651BCD1" modified="2018-11-07" version="1" fragment="single">GRGAKGEEREKKKRLELEDDVPCSMLHFGGGGGGGGGRSWKKDEKQWTTYLPPPTYSRTAEMVVMLILIFDNTPIIQSINQKKKTHIYRHSSSYYGPKPRRGNDDIIIKTAVVLTNHHST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRF1</accession>
    <name>A0A367LRF1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">25S rRNA (uridine-N(3))-methyltransferase BMT5-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_2989</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRF1"/>
    <dbReference type="STRING" id="1330021.A0A367LRF1"/>
    <dbReference type="OrthoDB" id="273345at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070042">
        <property type="term" value="F:rRNA (uridine-N3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019446">
        <property type="entry name" value="BMT5-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF26">
        <property type="entry name" value="FERREDOXIN-FOLD ANTICODON-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10354">
        <property type="entry name" value="BMT5-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="25S rRNA (uridine-N(3))-methyltransferase BMT5-like" evidence="2">
        <location>
            <begin position="51"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="25S rRNA (uridine-N(3))-methyltransferase BMT5-like" evidence="2">
        <location>
            <begin position="128"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI16930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="280" mass="31782" checksum="AE044ABEE2D86BDB" modified="2018-11-07" version="1">MAKQRSLRHPSKPKPARPVRKSCSSSSPARKKNKQPNRTTVIPFKRHDRILLVGEGDLSFAASLVRHHRCLRVTATVLDKDREELVGKYPTADDHIAVLVGSRSADDRGADEDVDEDEDEDEDEDKDGGKSTDVNRQVRHNQSLLVDFFHRFLPALNADGSFVVTLFDGEPYTLWNVRDLARHAGLAVHHSFAFDSSVYPGYRHARTAGVVRRRRRRHRGGDDDDDDDDEDEHEPAPNPWRGELRPARSYVFRRKDHVQALLAAAAAASKKRRRTDDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRM0</accession>
    <name>A0A367LRM0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRM0"/>
    <dbReference type="STRING" id="1330021.A0A367LRM0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013865">
        <property type="entry name" value="FAM32A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08555">
        <property type="entry name" value="FAM32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI17000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="73" mass="8165" checksum="A0631ABA0097FAEA" modified="2018-11-07" version="1">MPSDEYATIAGAGALRLKGAKVQKRKKKKKTKTTARRPSLLSPKPTPRARSQTPPTRREKLTTTTTTTTRRRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LSG3</accession>
    <name>A0A367LSG3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Velvet domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_2166</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LSG3"/>
    <dbReference type="STRING" id="1330021.A0A367LSG3"/>
    <dbReference type="OrthoDB" id="3056235at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF17">
        <property type="entry name" value="SEXUAL DEVELOPMENT REGULATOR VELC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="7">
        <location>
            <begin position="118"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="35"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="304"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="309"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI17182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="363" mass="39893" checksum="818E7D1D4F88A58D" modified="2018-11-07" version="1">MAWSRPAYHDPHVWRHARHNPLVAPSDPRLKAVARGVRTQDPSPGWEPAPAGAPNASPLLALTPSAQRSSLGADFHRNDGPRPSQPLTPRAQQVAAAADGTSAPTMPNLLAPGRAQALGDVRFSLRMRQQPRAARACGFGDRDRRVIDPPPIVQLVIESGSMTDDEVQSYLRYESYVMNCAICDETGTRDASFMPEGYQHQRRLMGALVGTPFVGRDDQGVDGCFFCFGDLSCRTPGAFRLKFTLIMIDPMRAGIIRHFPILTEAVSDVFHVYSAKEFPGMLPSSNLAKRLKEQGCIISIKKGNERSKPCSSSSSTTSSFPSSHHQHYHQQQPNRGDEASEVDEDAVDVVGQSNSRRRRLARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LSG5</accession>
    <name>A0A367LSG5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosomal RNA-processing protein 15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_2098</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRP15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LSG5"/>
    <dbReference type="STRING" id="1330021.A0A367LSG5"/>
    <dbReference type="OrthoDB" id="20949at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012459">
        <property type="entry name" value="Rrp15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13245">
        <property type="entry name" value="RRP15-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13245:SF14">
        <property type="entry name" value="RRP15-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07890">
        <property type="entry name" value="Rrp15p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI17394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="32043" checksum="BC4B52DA207FF72D" modified="2018-11-07" version="1">MAGLSNKKRPIEGRTQRAFKKQKKRYEYHSSDSESEQGVEPIDSDHDVLDAAVDESDGNEESSSDEESSSSKQRVKKKHKPKGNGVVAADNGGQDEDESNDDDDDVDDSDSDQSDRPKSSSRGKMKSKRNDPNAFATSLSKILSTKLSSSKRPDPVLARSAAAHEVSKAAVDSALEAKARRHLKEQKRKALEEGRVRDVLLATNNVEATTSTADLLIRERKLREVAKRGVIKMFNAVRAAQIKATEADKDAKRSGVITSDRRKQKINELSKKGFLELIASGGGGLRKAALEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LSI1</accession>
    <name>A0A367LSI1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_3134</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LSI1"/>
    <dbReference type="STRING" id="1330021.A0A367LSI1"/>
    <dbReference type="OrthoDB" id="10264707at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052742">
        <property type="entry name" value="Mito_N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43138">
        <property type="entry name" value="ACETYLTRANSFERASE, GNAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43138:SF2">
        <property type="entry name" value="PROTEIN SPT10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="72"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI17347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="230" mass="25421" checksum="1818B51E8874CAB8" modified="2018-11-07" version="1">MPAMLDDPARPAIRQWPSSENMPGPLPKARCVTLRDGHTKATILPFTSPDRVPASLLEFLCDQFNKEIEAGDTYPMVDAMTVAAFGEYWFQTFAAIMLLGVLDDVNASSNDDVDYWSDLCLGSYYVKPNYPGRSSHVCNAGFLVAEGARNRGVGRLLGESYVDWAPKLGFSYSVFNLVYESNLASIRIWDQLGFKPIGRVRGCGRLKSYPDKLVDAIIYGRELVDDGASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LSP2</accession>
    <name>A0A367LSP2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Structural maintenance of chromosomes protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_2929</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LSP2"/>
    <dbReference type="STRING" id="1330021.A0A367LSP2"/>
    <dbReference type="OrthoDB" id="10254973at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001301">
        <property type="entry name" value="Structural maintenance of chromosomes 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="12">
        <location>
            <begin position="47"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="233"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="393"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="676"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="791"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="881"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI17475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1089" mass="124094" checksum="715485A56FE79409" modified="2018-11-07" version="1">MAPSSSRRRRREASEDEESDSPKRRRVKLEADNLDATADNEFQPGAIVRVKVIDFVTYENAEFLPGPNLNMVIGPNGTGKSSLVCAICLGLGYSPKHLGRAGSVKEFVKHGKETATIEIELQKRPSDRANHVVRSQIRREQNSQKWWLNDKETTHKAVQILMKSLKIQVDNLCQFLPQDRVVEFAACTPVGLLHETLRAAAPEEMLEWQSQLQELHKDKKAMAQTTLVDAETLQTLETRQQGLQADVDRIREREEIQERVGNLRSALVLAKYSEVRNRYKEARERKKIAESALRRLQNESGPSLEAVNRKEEYVAKIDSAMPEIKETLKEAGKEVTDTLYNLTQAADVVKESKDKLDAEIKGFEKKKKDLAVSKQRITAHQADLKNQPPPFNAADWNQKIRAEEHNLRELNAEHRQASTDIEALKSKGKTVKNRTKDIEIELKALDTQQGQLLNLLKRRHPDVATGWEWLQEHKGEFEKEVFGPPMISCSVKDERYTDLVQTFLSNNDFLAFTVQTKNDLKKLSGEFYGVLSLSVDIRMSSQPLESHQPPMSTEEASTIGLDGFALDFLDGPAPVLSMFCSEKRMHQCGVSLKQHSDADYERILNCGRVSQWAAGKLAYIIRRRREYGPQAMATITRNVQPARFWTSQPVDSQEKADLNRLLLETKGELGAMIKEHTELRDKMSALDLRREETRKKMDALKSEKNTLQKEYQKWQSLPEKIESEERAKAAKEQAVREAKKSMADIMYEWDKATVKRAQLVTKHSELLGKMRGAHHASLEAKVRLIEARSDVAGLKRLNAGLMERLEAERQKVQTAAEEAATTKREGQELQLEVSNVVNRDGAKKELLTQLAEGKTPSDLEMDISAEEAKLDVIHAANPNVMREFERRAQEISRVRERMEASQERLAGLDQRLAELMNKWEPKLDELVSKINDAFAYNFEQISCAGEVRVHKDENFDLWALDIMVKFRENETLQQLTAHRQSGGERAVSTIFFLMALQSMAQSPFRVVDEINQGMDPRNERMVHERMVEIACCEHTSQYFLITPKLLTGLRYDAKMRVLCIASGEHMPRDGNKLDFARCLARQKTLMAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KYV3</accession>
    <name>A0A367KYV3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000051">
        <property type="protein sequence ID" value="RCI07346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KYV3"/>
    <dbReference type="OrthoDB" id="4930850at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI07346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="216" mass="23781" checksum="E9A9C0FC65023673" modified="2018-11-07" version="1" fragment="single">GTAATGSRVRQAAAAGVAPHFFQQGSKRSSINFSSGLSSSSNHDHHQHSTIITTALLPHQLVFSEIQFLTMGSLFENSFYVPNCSQYEPLSPTEPLSPSTVKEEERGETQAAEPGPPISQLHNTNSQGRITKRRSTKPRSYDSSDLLLSALKCTVGKHLRMTGYLPLSIDPGSKIDGKIMSWKEVEEWDMIMGEKRTVKFSIDFKVLMGHGNFTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZ29</accession>
    <name>A0A367KZ29_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_4542</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000028">
        <property type="protein sequence ID" value="RCI07435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZ29"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI07435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="69" mass="7833" checksum="C76257587D801070" modified="2018-11-07" version="1">MTLHESFSGDASQLLGTPAPYRHWVEKFKEGHHSLLPRSYVQFCISALSQEFPGLIDLTWIPLPYVSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZG3</accession>
    <name>A0A367KZG3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glutamate--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glutamyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_1629</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000026">
        <property type="protein sequence ID" value="RCI07565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZG3"/>
    <dbReference type="STRING" id="1330021.A0A367KZG3"/>
    <dbReference type="OrthoDB" id="428822at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00808">
        <property type="entry name" value="GluRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000045">
        <property type="entry name" value="Glutamate--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00022">
        <property type="entry name" value="Glu_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004527">
        <property type="entry name" value="Glu-tRNA-ligase_bac/mito"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049940">
        <property type="entry name" value="GluQ/Sye"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033910">
        <property type="entry name" value="GluRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00464">
        <property type="entry name" value="gltX_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43311:SF2">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="13">
        <location>
            <begin position="88"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="473"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="564"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="476"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="568"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="583"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI07565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="661" mass="73629" checksum="3DCB3F6C370C13FE" modified="2018-11-07" version="1">MLFPTLSSRPLGSRLCPRCSRLLRTPSSRLNHHQVDVAPPDPADILRPQQKVGGALSGLKGLRSRSNVLRPVNPSTRTILGQSASVPIRARFAPSPTGYMHLGSLRTALFNNLAARATKGGAFILRIEDTDQNRRVEDAEARLLSDLRWAGLSWDEGPDRGGPYGPYRQSERIHIYAHHVRQLLDNGHAYRCFCSSDQIESQKRLLHEEGMSTAYAGTCRAIDPEESRRRAESGERFVVRFKGDAHGRTRFRDAVYGLIQKKSDEEDFVILKSDGFPTYHLANVVDDHLMAITHVIRGELNPLRPQEWIISTPKHIALYAAFGWQPPTFAHLGLLVDTDGAKLSKRDDAVSLSKYQDGVVFPGALLSWLANLGSSFKQDAKTPRTVKDMADALTFKFTKGGIRLNFSKLQHFQTRYREALLSAPPSPTEAALIDRHLIQPLLREVDAITAGLKTTNMLPPAWQTSPLDLVPALRHSSSSSSSSSSSSSSSSSSSSSSSRTSYVKRIFALTQKDRFDCPTRRLIQQHHYLFWRVPPDLYRNSAATATATDRQVLDQLRRAVDGCWPDDVQADDDDDDDNDDKSSSPSDSRPEPSALHLIDVVRQNVRLDNPLVVHEILRLVGAGDRHVVSHSSACMLALLGRDEWRHRLSAVSDAWSTEPVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZJ7</accession>
    <name>A0A367KZJ7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_1652</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000026">
        <property type="protein sequence ID" value="RCI07613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367KZJ7"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF29">
        <property type="entry name" value="ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PKS/mFAS DH" evidence="11">
        <location>
            <begin position="456"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="2001"/>
            <end position="2078"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="9">
        <location>
            <begin position="456"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="9">
        <location>
            <begin position="588"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="9">
        <location>
            <position position="488"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="9">
        <location>
            <position position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI07613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="2082" mass="230193" checksum="C69E4F3B3DC639A1" modified="2018-11-07" version="1">MNNLSFTLDVHRGHLPWRAFAVVRSPTELLDLDSLVSNPVRARPKAPRLGFVFSGQGGQWVAMGRELLRYSSFKQDILCAGEYLRGLGCPWSAIDELSQPADKSRLDDADFCQPLITVLQVALVNLLRGFDVRPAAVVGHSSGEIAAAYACGCIDSESAWRLAYFRGLLSAELARTSREKGSMMSVGVSESRANDIITSLHLNTNPKSFGLSIACINSPTNVTVSGEEPLIDTLKTHLDGQKLFARKLRVPLAYHSPQMQATSDSYVSMVGSISAPRDTGASSDHPPMLSSVLGQRVDASKLLDSWYWVESIVRPVQFSRALSAMCDQSPSSLVKKIDRSHVFASAVDHVVEIGPHSTLQGPIRETIRTNSRETPVGYSSILRRGKSATETTFQALGELHSLGFPLSLRRANELGKENVSPSLLINLPQYPFDHSQRYWHETRMSRNYRLRSVPPSEFLGVRSRDWNSSDARWQYYIRTTEMAWPQHHVINGTTLYPATGMLAMAVEAAKQLAIEASERKLHGYTLQDVCFENPIDLSSTSGTPEISNCRGFIHIEFYESHDNWTRQRLDIQRNKATKMLESLLSSCKTPVPSQKMYYFLRECGYHYGQSFQAAHNQHCNEQRRQATADVDLCRLSEEDHVFHPTSLDAMLHLGFTALSAGGTAPMAASIPSHIRRIWISNDGLRWRPGRDSVATCTNVTSLTSRGFECSGGAFDKDESQELRLWYEGLELTSVTRTQSWLSIPNPKQWFMNTDCKVDIGSLNNDEVFSLLNERHPVEEAPPGFVDDLELLVELSLERLGRVLDPSRFMGNCTWKGRYWSWAQNYLSRRRLEGSLQDDRGPISGQLSSSTVERHLEELTARLEEVNHVGRVYSQVASNLVSLFDDEMDPLELLVHSGLLRGYYSELCDYRCAKQAFTYIDLLAHETPGLRILEVGGGTGATARNLVHILRSGSNGKPESHSLRCGRYEFTDISRAFTEKAREEFAPYDAQFGLKTLDIEHDPVSQGFEAAAYDVVVADNVIHATSNLAQTLRNVQKLLKPGGKLLIQEPLKASGGTLGFVFGLFNGWWAASEVERNLCPAITADGWDAALKKNGFSGADIVMKDFEDDVAHHLGWLVSTAINRGSGLISNGSLKQPDWRVKATVVINKSCAEQQSLSDALLPLLHESLGLDAQVVDVETAALVSQRDDKELVILLVDYGWDFLHSLDATSYAWLKSLVRASRRILWVFGSGAWDVSPDHGLVDGLARALRAEYYELQLVTLVLDMRKHGADKLPHIVRVAGRMLSQDARQAYEQEYLEIGGFLHTRRLVVASDLKSTIHGKLVPYENVKTRLDGQNRFELSTLTFDPNAVPCFVRPEISEMPRTGEAEEVEHVINLLVKAACLQPHHRSTALGQRSSPSDSPFYFMCSGVVLSAGTDHRPGMEEAIQTGDRVLFAWNGPLCSHVRLPWRYAVKIPDELSFAGACAGSPFLAAAYHALIERGGLNSRHSLLVRHGASPIGQAALRILRERDMKNIWTTASGKDECGWIMETFGIDDDRILPDDWFRNQPMMLSQLETKFDIILTAGIDATQQLLLYHVKPGGRHIFIDTGSTMQHNSHFIHGVPANVSHDSFHMGSISQGNPEPSISVASLECAVRHARAMNKDSPELQEKIFPASDVANAFKLLQKADAGSVIIGFDESDAVEVRIMTRPAYSFSSDASYLIVGGFGGLGRSMARWLVSRGARHLILLSRSGPRTDKAQQLLSELRSQGVTLEAPCCDVSDETALSAALASCRETMPPIKGCIQSSMVEIETIFEKMSFSDWKAALDPKVQGSWNLHRQLPKGLDFFILISSAMGTIGGVSLSAYCAANSFMDALARYRVSTGERAAALGLGIIADSGFLIENGERLAGFEGIERYAFTRLREVCALLDIYCDPRPSNALSRSVVDCQPVTGIRPPAHWRHLEDVPKTFSQPFWGHMHHLAPLVLEGEDDGSKDRADTVGNRHRQALDAAERLSAASSVAEAADIASEALAQRTSAVICTPEDRLDAHKPMHSYGIDSLSAIDIRNWVGQVFNVDLPVFEILGGATFASAGLSIARKVQLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L005</accession>
    <name>A0A367L005_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_5749</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000024">
        <property type="protein sequence ID" value="RCI07760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L005"/>
    <dbReference type="OrthoDB" id="10062838at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026505">
        <property type="entry name" value="Solute_c_fam_35_mem_F3/F4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19346:SF4">
        <property type="entry name" value="SUGAR PHOSPHATE TRANSPORTER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="437"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI07760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="488" mass="53335" checksum="C5F0A9082B91A44E" modified="2018-11-07" version="1">MNADDNGAKNRRGDAPDNTAAAGSPERHTEPANGDLAGVPLLYKPEVAANGDSGRSLLWSSDNYDAEAEHGHEDDNDEDDARPPPFSRRSTMRSRSPLAAAAQAEASTRKKYTYAAFFLAVSLVTFAIQTELSAHIQHDLGWDKAYCMMYFTHGSWVVLWPAMLLVLRLQKREEPWPVFWRRHKQLLVSTVAMIELQTLDVFSSSARRRARPAFYLIRTTAFITSALTVAGLSWYVAVSLTTPSDLTAIYNCSAFFAYVFSVPILREPLRLDKSVAVFIAIVGVLIVAYGDTGEAEKSHQPGTGSRFVGNLVIGIGSVLYGLYEVLYKRYACPPEGVSPGRGTIFANTFGACIGFFTLTVLWIPLPILHVLGIEKFELPNASTGWLILVAVLANATFSGSFLVLISLTSPVLSSVAALLTIFIVALADWFITGQPLSWAAIIGGSMIIVAFLGLSWSTYREMTEHEVRKLAVDLTDSEEDADRAAGDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0E8</accession>
    <name>A0A367L0E8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000023">
        <property type="protein sequence ID" value="RCI07877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0E8"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI07877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="447" mass="49576" checksum="87D094433C012010" modified="2018-11-07" version="1">MMIQHNKLPSKLLLYPIFFWCNCCNSPVSFVNGEQQGAEDEKWRHGWLAVLAETSSGCYHQPASPSHASSLHIPRAAARHDRAIVSVEQQFGSACLRNTTVAMDPYFGGKEKLFYDFSNRQPTCRLWEAKTARRASAPWLDCHDQYRAPRTKSGAENRFRSLRWLERRRAPSSASRVRKSKWKKEKKRKKTTTLIDEDDAEGNRFRHTWPSPQDPGQIKPIFRVNILRLICARVRRGRAARFAKHDPVGFITVLNLLKDDLSTCRKQTPSSSLPNTVALYIPTGFGPSASSALSSGGRGLVGALQALGAMGVGQWSMAAGDGRSWWTRAEGQTQGASSSSSFSSSSSTSSSCSSFQPTPPFFTFKPRDSRDCTCFEGPSRSNEWDMQLNTYQEIALSIRGTPFSGLDAPPLCFFFFSLGLFSVSFSKWAGGGRSPSIPPPPSPIIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0N1</accession>
    <name>A0A367L0N1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000022">
        <property type="protein sequence ID" value="RCI07993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0N1"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI07993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="109" mass="11876" checksum="327BCE0EBF608929" modified="2018-11-07" version="1" fragment="single">PKARHNALSHSGAIARSSQRSARCTYSGHSTRLISAQGSRHIDRRAILIAVIALDQSDRRAVLIAVIAPDLDSRTKALRMDSLLIREKLQGALGSKTYNKSEEAGLEQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0Z3</accession>
    <name>A0A367L0Z3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_6350</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0Z3"/>
    <dbReference type="STRING" id="1330021.A0A367L0Z3"/>
    <dbReference type="OrthoDB" id="73680at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13316">
        <property type="entry name" value="PH_Boi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09535">
        <property type="entry name" value="SAM_BOI-like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.50:FF:000082">
        <property type="entry name" value="Polarized growth protein boi2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037370">
        <property type="entry name" value="Pleckstrin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12092:SF16">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12092">
        <property type="entry name" value="PLECKSTRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="14"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="SAM" evidence="6">
        <location>
            <begin position="229"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="5">
        <location>
            <begin position="721"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="89"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="297"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="490"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="628"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="902"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="95"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="111"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="309"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="326"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="490"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="644"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="679"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="906"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="919"/>
            <end position="929"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI08109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="979" mass="105587" checksum="19AB928A6F6D665E" modified="2018-11-07" version="1">MASRAPNEPQPRPEVGDTLIVIHDFQARSSDELSLAKGDRVELIERDDEFGDGWFLGRHLVNNNTGLFPEAPRTMPVFSLSKPLPPVAEVNQDGSAAPVPSASPNAAQSPITSMTAGNTRDVSTTLPLKSPKPDATASPSVASSGSPASGLGRLDNHSQDSQVLNETLNVINEHITDLRSPPSVGVLRAPTDSGSEYSAPIDHRMSYIQGEETDEEEDGFHSRAEVEAWSPDEVADYLFTVGVEKHHCEVFRDQEISGEVLLGMDQSSLFIKAFDLGSVGRRLKTWQKIKALQDETNSHSLTMKHSTRRHDSGPGSDDSKRSRSRNNTLTSPVSNRPSSSQTQRVSSAHTSTKFSPPSLYPPASPPSARESPTQAGSVKRPSAASIRELNHSRRHSSNDFRLSGPAHGAVVPALNTSKVGGGTEATHTKQPSFDRNWTLGTAFSQPPRPLSSAGLHDTLVGSDPDMLQDSAVDLDRGYFSGTEVDGRRRNVLRKRDSMNHSRKSSYAEEQRVRSATALSRHSRFGSIDSYPDGGGPPSAAQKYYGLQATPHRRTASTTTVESPRPPPPAKDGLSPTVTNLDGVSRPHVSPSTAAKNAGLNSDWLSTVVSKPMGKGRPGMRAISEKLVTSRFKDPDAPEVPSKEPSLNSPTRTGSSTPSAGPSMDTPSAGPSMELESPGTGKSSILTTTPASRASNKKKGKKDTSAYTRGLQNIRPAEAKKDADYYGWMRKKSSNLMTTWKPRLFVLKGRRLAYYYSEEDDQEKGLIDISFHRVLPADNEKLTGLHATITGAVGGPSIPVVSFLPGGGGDSPSSHDSTFIFKLVPPRAGLSRAVNFTKPTVHYFAVPSLQQGRLWMAALVKATIDRDDTQPVTSTYQQKTISLAKAKQMQHRPPALMNLGELSEEGQQQQQQQQQQQQQQRRRQQQQHKGRNVEGLGIFGEADSGVSGIDRLAGGKGELSPLSVDVPDKPAGLSSSSHGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L120</accession>
    <name>A0A367L120_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_6313</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L120"/>
    <dbReference type="STRING" id="1330021.A0A367L120"/>
    <dbReference type="OrthoDB" id="202672at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024512">
        <property type="entry name" value="Ser_palmitoyltrfase_ssu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11779">
        <property type="entry name" value="SPT_ssu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI08133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="97" mass="11421" checksum="41FC06991B63B87B" modified="2018-11-07" version="1">MTYLVDARRWLHRKQYQFEVTFGVYMHTAWEKFAIYSVVFLLFGLAFIAAILYLPHHVFRLAGRAWYYLQGDEELDLAVSSDAVLVAGRDLFVDREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L182</accession>
    <name>A0A367L182_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_6224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L182"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI08157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="96" mass="10929" checksum="B0E5D0EE9F9F29FE" modified="2018-11-07" version="1">MALRVLVFIQVVVGDLRLAREVDEHACSRTVSDEKVACLSAEKKKKISKEGLFRRSLDRSPLFMYLCYTAVLSLASVELNPHMDDMISTFSLRYLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1G4</accession>
    <name>A0A367L1G4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_8356</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000020">
        <property type="protein sequence ID" value="RCI08261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1G4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI08261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="104" mass="11695" checksum="CA32F5833A4D227B" modified="2018-11-07" version="1">MMMSNRGVDHVIEKKKTNHVIVGKPPSFIDKFLNNKDFNVIDQPDDLTLRVDRCDDHLQRADRCNGCLVPRSIGCYDRYRYSAPIAVTIAVTSRSGAMTAIALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1J6</accession>
    <name>A0A367L1J6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1J6"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="61" mass="6498" checksum="94CDB68DF2C94D57" modified="2018-11-07" version="1" fragment="single">MTLAARGVGKKNEAGIKKGGGGGGVGHPGPCADTTRRLVQRRDAASNAYRYTLYTYRPYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1R7</accession>
    <name>A0A367L1R7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_8961</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1R7"/>
    <dbReference type="STRING" id="1330021.A0A367L1R7"/>
    <dbReference type="OrthoDB" id="2406834at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF81">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="784"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="5">
        <location>
            <begin position="286"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="65"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI08356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="820" mass="90656" checksum="BA530FFDED47AD20" modified="2018-11-07" version="1">MEFHRTHHLHHQPPSASAPEHEHDSPRKKQKRNKPTLSCHDATEDGLIASLASLAAFDLVETSRSAANGRRMTRPPKKKTTTTTTTTTTTTATGKPTIPNIADRGAIDDHDASSRGAVALSIGLLSHVPYSVTSASNVFGIGSEHPFANYWTCEGGLPEVISVLPEKAQADILLARYFECVDPVYPMIYRQTFYAEYEHFWQPASRQREETDAAFVGLVFVMLALGTQFVTSTSAKERKQTAEFYASASNQALRLSSYLSTASLCSIQAMVLITYFLINDNHASDGWAFAGVLIRQSYAMGLHRDPNIVTPNASPFEKQQRRKVWQAVLLQDTFLTVLLSLPPSATHTDVSVDDLLDDSSSIASSDPTDTAYIRGSWMLANLVQETICSPRSLDMAICATARHKTKLVADFRAVYRSFPDVFRSWDGCSLTQLAATNKRIVRQTLFLSSNYFHNLMLVHASESPEVPVNIRGTLEAAHGAISAFFLFYSLLEFEARVWWVFNHRAFLEALCIGNVLREVAKEAGGMDVITRDPLFARARTDITRMMQIMEFVGEDSDCPPSAFIGPALQKAGKSPPSPRLVVCIGSTLPALCKPTYRRARKKPCIMRRLDICRVVAVLLLTPCALSRPVTWHFKASVTPRAVLGPSCSSWLPTLLQCDDDQSPSKSAQTTQAECVVISHHSLADSVRRPNASLGSAHRRLSFDPWLRRWMSMMRHIGIAASRLGSELEELKDFVIHAVDDAPPTPNDEGEYVDWYVGADAFGELWGSGADEDGYYSLRPRQPPLLVAVALAALAVGLFSFWCLHVRTVGLCVEEFRAASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1Z6</accession>
    <name>A0A367L1Z6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_8796</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1Z6"/>
    <dbReference type="STRING" id="1330021.A0A367L1Z6"/>
    <dbReference type="OrthoDB" id="447251at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429:SF9">
        <property type="entry name" value="PAS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429">
        <property type="entry name" value="PROTEIN TWIN LOV 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0157">Chromophore</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAC" evidence="5">
        <location>
            <begin position="311"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="51"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="406"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="636"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="413"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="426"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="673"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="697"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="738"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="809"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI08434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="841" mass="92817" checksum="D97A12F9C9528FC8" modified="2018-11-07" version="1">MSRSASAAAFQPLSPVPRFEPLVEPEMVSRMANGRAGSDVSFDDVDLAVKPLPPPPLTPPCRDGESELPPLQTANGEPEGLDPVDGDDGSFDLVMPATTNGSGGDGQGRVHELELRSDLLFSRRHLRAIFDDPTHLHRFTSFLYQYRPESVPLLTYYLEALKALRAIEYSNAVLRRLEPPPDIGLTEDWFRTGPTSNEALQAKADAAFELLTREDLPMFVTHVWIHTVTMSIRHRIRGTLPHASEGLAEVFCLTDPSRHDNPIVFMSDEFNRTTQYGVDYVIGRNCRFLQGPHTNPFSISRIRHRLEAGLEHYETFLNYRRDGSPFMNLVMLAPLYDSRGTIRYFIGAQVDVSGLVRACYGLGALKKLVDEDQQAREAPPSPPRSTDEFTQLAEILGPRELDIVREHGGDMYRPPPRDGPIPTGPQERRDSVRRPDADAPPPGDAGNGASRHRVVLRDPESPNTDGVPYEAAAQLSSGPPSSAAMLSVQHNGRLTGVYENYLLVRPYPSLRILFTSPSMRMPGILQSPLLDRIGGSARIRQQFVQALSQGQGVTAKVKWLTRLASHGSRPPRKKMHYNHPLEAHLDAGDDTDTLGELEPVGRSRWLHCTPLLGSNGKVGVWMVVIVDDELDAIGRHGGHPRPGTAISETSDDDQIHGFMPEGRPMVRPRKSSETLGTQPTMTSKDQDPSAIEPIHQKSPHAVKVKNGQRRRGRRSSSNSPARPLPFYGHSSFAGIPSRGSTPFRSENGRQSPHHGEDVVGGGGSGPPSIREGRTETPMPSWPLPPFMSPTTRKKREHQIYVPPSIPETSYERGVIRGREDGETSSTGSRGSAFTVRIEEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L214</accession>
    <name>A0A367L214_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_8934</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L214"/>
    <dbReference type="OrthoDB" id="300709at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF7">
        <property type="entry name" value="NMRA LIKE REDOX SENSOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="3"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI08455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="221" mass="23630" checksum="8AAC5F8A567B7365" modified="2018-11-07" version="1">MPSVIAVFGATGKQGGAVARSLLLNKSAFHVRAITRNPNSEASRRLAEAGADVVQADGFDRQQMRRAFDGCWGCFVNLNSDDPLFRQPGAPSEVDLGKGIVDAAVDAGVEHLVFSSGPPCVEMTGGKVNMKAMESTGKKTRFAPLLPDWNAFDTHGIPELDDVKLMFAFTQTTDGLYFGPETSQTVTAAELKRATSEALSRPAADAGLVSPREWFAKHFGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2A6</accession>
    <name>A0A367L2A6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylglycerol/phosphatidylinositol transfer protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_8924</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NPC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2A6"/>
    <dbReference type="STRING" id="1330021.A0A367L2A6"/>
    <dbReference type="OrthoDB" id="6409159at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00917">
        <property type="entry name" value="PG-PI_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003172">
        <property type="entry name" value="ML_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033917">
        <property type="entry name" value="ML_PG-PI_TP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039670">
        <property type="entry name" value="NPC2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306">
        <property type="entry name" value="NIEMANN PICK TYPE C2 PROTEIN NPC2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11306:SF0">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROL_PHOSPHATIDYLINOSITOL TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02221">
        <property type="entry name" value="E1_DerP2_DerF2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ML"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016811638" description="Phosphatidylglycerol/phosphatidylinositol transfer protein" evidence="8">
        <location>
            <begin position="20"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="MD-2-related lipid-recognition" evidence="9">
        <location>
            <begin position="32"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI08537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="168" mass="18189" checksum="F760B69C820A7464" modified="2018-11-07" version="1">MRFSTTVALLSACLAPAVAVNDDHVVPGGSPLRFCDGPIVKEFVDIKSVELTPKFPEASGSNLTIEARGIVHKDILEGAYVRINVKWGLITLLNSKMDLCEQTSHIDLECPIKAGDMSLKKTVQLPSAIPDGTYHVMADVYSKNEEHITCLTASITFSGQGLFSNLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3N9</accession>
    <name>A0A367L3N9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AN1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_5142</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI09045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1330021.A0A367L3N9"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="5">
        <location>
            <begin position="2"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI09045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="72" mass="8182" checksum="B5A4C7838734B572" modified="2018-11-07" version="1">MAPKKIRCNAKDCKEPAQRIVGDCTFCKGHFCGNHRLLEDHKCSGLEDCKRQSHERNAAQLESERTQVIRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3X7</accession>
    <name>A0A367L3X7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_1544</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3X7"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI09136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="82" mass="9567" checksum="38F19E556DFA849E" modified="2018-11-07" version="1">MGWDERISNEADEKRLKERAWEAALCDDDDDDDDDEDDDDDESYLSSVLYGAGWPKLCFFFTFMLRPGNHDSMNYEPFSLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3Y2</accession>
    <name>A0A367L3Y2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3Y2"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="700"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="815"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="290"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="390"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="450"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="479"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="505"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="545"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="669"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="713"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="755"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="831"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="888"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1061"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1061" mass="104486" checksum="2EAD0A9DA513CC73" modified="2018-11-07" version="1" fragment="single">DGSAAGSGTSNRGGGGGSAGGGSAAGSGNANGGSGSGGGAEAGKSGGGGSSSIGLDSKVKVGQGDNSTAGSSSADGGSDESSVAGAAGAKSATDSTSGSAGGPASTGNASGGGSNDGSQTASTGSTGQQQTWGSGGSSEKSGANGTCSETVSATGAPSVPGSGSVAAPAATSWSSGISYSGATPISTPAVSFSRLTGGGSAGNHGAGTSSSKNSTSGGSGSTSDSSGSSSSISGGAGGNNPKKGASPNAGQKASSAGSSNGSNGSSGSRSGAGSKADSSNDRSGGGSGNGFTSMNSKNSTSDDSETSSRHSSTSEEGGNGSGSDGSSGWRSISSSSSYNQTGNGSNSSSSYYSFRSGPGGDSNGRPNGGSFGYTLLRGSDDGSGNDYENNEFSSGNRGSNSRFSSASDSGNGSGSGNHYSSYTTGSNGRKGRKGHHKGNSGNGRNGGGSSYYSSYSSGNNSADDNDDGAGNDSDGGGNSYYSSYSSGNSNGPMNNTFNDSDSDGDGSNSYYSYYSSGNSDGSDDDNSDTIDDNSDNDSDDGDSNGGSYYSSYSSAGNGSNTNSGSNGARTLRRWFSSDDGGDVGHGSSYKPGRSLDKRSPGGFSDELERGMDYGLEDGQAKAAASGSKVGYAGSSPEDDDDDESSGVYRFPTTDSKDGQRTATADELQDSSWAKSGSASAYTGDLSNTIADEVNTGFAMGSARKAKNVVTSPSDDDALGLDDEDEHTAYWGSGDNMTPSRGKFDYDDAAVPGQGNAVTQQQSQQRLGLDEASPLLSGGIDTPLGQGSFGADVGALPGRKGVNSTAMVQGTLKDSAFLGGGKFSNTTTNNNPSGGNKANMAATNDTALPGNKRVNSTMTAPGSLMDAVPFSGGGKSINDVGRGGPRSKAANDDGDRDEETKTNDDSMMISHGPRPHPPSNKAKGTSLAKDNDDSDDAANDCTEVLTVTMTATETKTMTKTTTKTTTKTTTKTTTTTVTAMPEHSEQPVVGGVHKLPPSPGMAKNFFNSTVVDFTSQTLLATVGTEAMRTAPTAIPATKTANCASLHPSGFTTISRMRKDMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4B7</accession>
    <name>A0A367L4B7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_1512</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4B7"/>
    <dbReference type="STRING" id="1330021.A0A367L4B7"/>
    <dbReference type="OrthoDB" id="1204at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070772">
        <property type="term" value="C:PAS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010513">
        <property type="term" value="P:positive regulation of phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903778">
        <property type="term" value="P:protein localization to vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000011">
        <property type="term" value="P:vacuole inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024260">
        <property type="entry name" value="Vac7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28258">
        <property type="entry name" value="VACUOLAR SEGREGATION PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28258:SF1">
        <property type="entry name" value="VACUOLAR SEGREGATION PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12751">
        <property type="entry name" value="Vac7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="604"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="692"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="795"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="800"/>
            <end position="817"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI09269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="828" mass="88100" checksum="1C63A74F76ADBBA0" modified="2018-11-07" version="1">MEKSQAVVGDGATQSPAADDVEPAKAPTPPPPSAAMPSSATTSLAPSPESSPISNPHRQTSSSTGPVGRSRNNSQQTRPAAETPTTNTLSSATTPNLRPANRDAQAQLPAPQKPPALQELKDSHRWPVSPRLRSPPPQPSKPSTARRSDHDPPLISIQRPSLSPLSPDFSQHPLESEPDDSHMQCQSGMRTPIRGPLETVQEVSQNNSPAQPPPNPSSSLDSAKDNKPAGSDCHSDSALSDTGRAHGFKSSTSSTHAPPGEATSSKAEMPRSSAVPGPPSRQSSALSTKQLKSKPEGSTQTMTVETETVPSVPQVVLATGTKSESANGSLKTKPSAETIKPKKDKKKPARKQPPVNSGTGSSKADIFEAKIASAVDEANTSDSEETFVYDSNPPDNTERSNRRFHSRTPSATSMVSQADRSNLRSIYGVMEGGGHTHGPVPKKSMKFVNTFGGNASDSLTPGDDDGKGTGRSAGGSARGTLRHHHHIGRWGRQPGNGHASLFDNESPFHNAAANKSKLAPRDVSGPPSPRLYQTARTHLSTKRSSMQMSSSYDLDDTGADDERTPLLESGRSLRGSRSRRGGPHNLRQAESQTYTRRSSYLNRFAACLVLTIMFLLVITGAIGFMFATSQPMTDIEIVSIGNVVTSEQVLMFDLTVKAHNPNIVVITIDHANLEIFAKSEFANPYSHVGVLDDPINDPPPGPGEDGDGDNDSRPNMLLGRIVSFDSSLTFEGSLFHQGTSKSTGELQLPYPGNNTVGGSARWVRIHQHEFDLIVKGVVKYSLPLSAHVRSATVAGRTTVKPNSANKPSPKPNKTSTADVGREDFAWVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4E4</accession>
    <name>A0A367L4E4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_1473</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4E4"/>
    <dbReference type="STRING" id="1330021.A0A367L4E4"/>
    <dbReference type="OrthoDB" id="1878542at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF147">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G01950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="25"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="7">
        <location>
            <begin position="295"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI09287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="433" mass="46847" checksum="8871E7C11EF7BE63" modified="2018-11-07" version="1">MTSSSPSSSSSSSSRYHPPETSSETNFVIAGAGIAGLATGLGLSLTGQQVTILEQASTLEEAGAGIQVAPNASRILARLGVLDEVMKDADVLERVSIRRYADDKQLGLAPIMPNASHRYGSPALVIHRSDLHRILLSSARKAGCRILTSRRVVSVQDNTNNNNSTGKPRVQTEDGEWHEADVILGADGVRSVVRAHVVGHQVPLTPTGDAAYRLLIPRERMAGHETLGALVEGGDATRWVGPRGHIMGYPILRRPKSAVVTFCHNWSRPVRDLVSCAPEGQVTEWLLRTHPPLPRWTRHRVALVGDACHPMLPYMAQGAACAIEDAGALVAAFVCAPDPDAALHLYERVRKPQSESVQEASASQRECLHLPDGIHQVRRDDAIRRALEPSAHHHVRNPDLWLDRSWQDSVWGSDVVEDIFQAASSPAAGERGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4G9</accession>
    <name>A0A367L4G9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenosine deaminase</fullName>
            <ecNumber evidence="4">3.5.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_1414</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>adenosine + H2O + H(+) = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.4" evidence="4"/>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4G9"/>
    <dbReference type="STRING" id="1330021.A0A367L4G9"/>
    <dbReference type="OrthoDB" id="7202371at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000017">
        <property type="entry name" value="Adenosine deaminase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF39">
        <property type="entry name" value="ADENOSINE DEAMINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="11">
        <location>
            <begin position="224"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="565"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="569"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI09333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="590" mass="66512" checksum="A5A0529A921B718F" modified="2018-11-07" version="1">MAMADDVWEELSQDIPSATDPFIQQFLAGREGLIDQEQAARSDTSFRNSMSPVARSACAVVDAIRRREQATVWVPKHERDDVVFPGMMFRLAKDRIEETALWRIIRRMPKGCLLHAHMDAMVDFDFLLDELLATPGMHMASDRSICSSAAREEACLFFRYRAESRTGGSVWDEAYQPNEFLLLTHLADSFPEGGRKGFLAWLKSRCMLSLADCHEHHLGIDAIWAKFTLCFRTVATIIHYEPMFRAFLRRLMHLLVADGVTWAELRFTWALDYCRERKEEPEKDYSHMFKVLEQEVARFKKSAEGKGFWGLRTIWTSLRNCDTRPLIENMDHCITTKMEFPHLVAGYDVVGPEDLGKPLIDLLPELFWFRKQCSNENVNIPFFFHAGETLGDGSGADENLYDAVLLGTRRIGHGFSLYKHPLLIDMVKEKHILIESCPVSNEVLRLCGSIMSHPLPALLARGVPCCLANDDPAMLGQGTAGMSHDFWQALQGWGNLGLAGLGSLAENSVRWAAFEDQDAAEWSRDVKQASLGDGIKAQRLKEWRVEWEKFCLWIVTEFGDEVEDEASLVEEGGAAEGSAAAEAANEPGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4I7</accession>
    <name>A0A367L4I7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">5'-Nucleotidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_3694</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000015">
        <property type="protein sequence ID" value="RCI09345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4I7"/>
    <dbReference type="STRING" id="1330021.A0A367L4I7"/>
    <dbReference type="OrthoDB" id="7722975at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07409">
        <property type="entry name" value="MPP_CD73_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000020">
        <property type="entry name" value="NT5E isoform 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF24">
        <property type="entry name" value="5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="7">
        <location>
            <begin position="36"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="5'-Nucleotidase C-terminal" evidence="8">
        <location>
            <begin position="336"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI09345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="544" mass="60878" checksum="221E9AC4B0E8413E" modified="2018-11-07" version="1">MFYVLSRQPFASVDDFLPSQRLLKRGLAYDGNYQISFFHVNDVHGRLDQFNEYGTDCTDPAQDCYGGYSRIKTRVNELRQQNPDSLFLNAGDEFQGTLFFTLFGGEKIAETLNDVKFDAMTLGNHEWDLGDEELGKFLDKLDFPIVACNVKSSYPALEENIKDYHIFPSHQLAVIGVVTETTATTSRVGQGTTFLDPIPQVQKTINEIRSLHPEIKRIVALSHLGFDIDQKLAAETEGLSLIIGGHTNTLLGDMENAEGKYPTVEKNAQGHQVLIVTAYRWGEYLGRIDVTFDLDGRPVAYDGAPEHLDKTVKQEKTLQDKIQSWRSAFGEYALQVGETATLLSGEDCWRRDCLMGQVLTDAMLEYANENLTETEARPDFAFINSGIIRASLAPGKITKGDLRTCFPFETTLVQVTYSGAELGKMIEGCISKVNQFNHKPVTSWFQVSDGVAVDYDASQPAGSQVAEIRINKQPLSERRDYRMVTGEYLVNGGDNMMPKGRDVTVIGGAEKALVWYLGKMRPLNVRLRERVGSIQGKKGHRRPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4Q6</accession>
    <name>A0A367L4Q6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_3750</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000015">
        <property type="protein sequence ID" value="RCI09423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4Q6"/>
    <dbReference type="STRING" id="1330021.A0A367L4Q6"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050935">
        <property type="entry name" value="Bromo_chromatin_reader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880:SF225">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN BET-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880">
        <property type="entry name" value="FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="282"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="148"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI09423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="377" mass="42010" checksum="29C7A7D83C3D189F" modified="2018-11-07" version="1">MAYFDSQGTTDKVEHLVRLPEFAADVFGLAQNFLYTGVLLSDETAAHSYETLVSLWKLGYELGIDGLCDTALDAMTECRRLTQRIPAAPLLIQVWRDAPEGSSIRFLLLSWAAEYMRRSDARAEFARSLPQEVLSELVVAMSSAEQSVTESSSVAAPRKSVHYLSDDEDTSRSVKTKKTRRTSEGPTTRADQTTSTTNRTPSVAKAQKRRSSSSAAAAAAAAAMTTNPDGRAFTTAQKLDFCADLLTRMLSGPGKKKTAHRGRRRRGLDKGGSGFWTRLVGPFKDPVEPVEDGVPDYLEKIKRPMDLGTIKAKVDRREYKDEAEFLADMRQIFDNCFTYWKKGDPMWAAGEKLQKTFEDKYSHMNRWISKMGGEEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5K8</accession>
    <name>A0A367L5K8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA damage-inducible protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_4090</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable aspartic protease. May be involved in the regulation of exocytosis. Acts as a linker between the 19S proteasome and polyubiquitinated proteins via UBA domain interactions with ubiquitin for their subsequent degradation. Required for S-phase checkpoint control.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds ubiquitin and polyubiquitinated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DDI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5K8"/>
    <dbReference type="STRING" id="1330021.A0A367L5K8"/>
    <dbReference type="OrthoDB" id="1047367at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05479">
        <property type="entry name" value="RP_DDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01796">
        <property type="entry name" value="Ubl_Ddi1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033882">
        <property type="entry name" value="DDI1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019103">
        <property type="entry name" value="Peptidase_aspartic_DDI1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12917">
        <property type="entry name" value="ASPARTYL PROTEASE DDI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12917:SF1">
        <property type="entry name" value="AT13091P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09668">
        <property type="entry name" value="Asp_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="12">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="11">
        <location>
            <begin position="407"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="83"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="340"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="93"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="367"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="378"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI09709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="446" mass="48914" checksum="21FFDB0A52F8B03C" modified="2018-11-07" version="1">MRITLNVFNNPQATEQESLLQLEIFPDMTLSTLRESLHAESNVPPTSQHIYHNGRLISDDAKTMEQLQIADGDMLAVHVRETRGATAAHGQAQRPQDQPSSTQPRRRQGGDNDPEMLRLQLLGNPVLRQQLQSTQPELAAAVDDPARFARLLHEAQDQERRDRLERLREVERLNEDPFNIENQRKIEDMIRQERVMENLQNAMEHNPEVFGRVHMLYVNVEVNGHKVKAFVDSGAQATIISPSCAEACGIMRLVDTRFAGVARGVGTANIIGRVHSAQIKIGSLHLPCSFTVMEGKSTDLLLGLDMLKRYQATLDLARDRLVIQGEEIPFLGEADIPKEEEQAVAQEPTIPGPAGTTIGQRSGVVMPPEQAPASQQAPTPPQSAPSRQPPPQGAMPPPSQGQPAGPNVTPAHVESLVGMGATREQAVQALQAAEDNVDVAASLIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5U1</accession>
    <name>A0A367L5U1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphatidylinositol-specific phospholipase C X domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_4030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5U1"/>
    <dbReference type="STRING" id="1330021.A0A367L5U1"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF113">
        <property type="entry name" value="SI:DKEY-266F7.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016786517" description="Phosphatidylinositol-specific phospholipase C X domain-containing protein" evidence="2">
        <location>
            <begin position="27"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidylinositol-specific phospholipase C X" evidence="3">
        <location>
            <begin position="69"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI09800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="336" mass="37514" checksum="6E8B5537ABD440E0" modified="2018-11-07" version="1">MASLFLTTTLLITTLHHNSLPFLSHASPLEPHNGPPGDGDDDTTNNSRSHAYSFDADASHRPSWMASLPDERNLSSLSIPGTHDTMTHTLRNVSHFWCQNHGLDTQLVAGMRYFDIRLRLRNDSLPIYHGSGDTNYSLPQVLDTMTRFLESHPSEALVVRVKDEGNPLGTNTISFEDAFARDVKPYRRILPAHDPARPLPSLGQVRGSIFLLQEFKSIRRRYGLEWDGASMVLEDWWIAGCKPTPSNNSHLYLSHISATGYELLPVEAAAGPANRSVSGLNDLTGHWLENCRDKLPHSRVGIVILDFPGRRAIDAVLDWNSQPPRSIRRRGIDSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L680</accession>
    <name>A0A367L680_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_8617</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI09930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L680"/>
    <dbReference type="STRING" id="1330021.A0A367L680"/>
    <dbReference type="OrthoDB" id="3543857at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="3">
        <location>
            <begin position="343"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="152"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="446"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="241"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="258"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="311"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="464"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI09930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="480" mass="52948" checksum="C538E9E0C4E73CD2" modified="2018-11-07" version="1">MAPTPLAKLRTRKGKPGPGRLVVPLPSRPPPYQPGSGPPLQRIRLLPPRDSTAYIVERILLPSPGPAPADGKPLPRRMAYIVGWSDLPAARLLVPVMQVLEYVSPRALEEWEANMELELDEDRRILAEEKGSSGTQRKARPPAHTEIESAAVAEAETDAQSRPKVSAMSLSTPKKARLEDFEGFTDYEEGSPSGQLARESAWQEDEGDEIRVISDLPDATAPGWPLPEEEEEEEGGGGFTAPSTTPQFASASATQHFSLLSSQTLTSGGNLSQGVSGGFTPFNQNRRLYSMPQAPRPSGVPSHMTPTKTQRQSKPRKKSTPAKKADAAPEPAAAMAQQEEDWVVKDIQDVQLYEVEGRGLVRYFKVLWEGSWPPDQNPTWEPEENLPPNMVRNYFKLSKKKRKARANRFKTKKKKTTSTSTTTTMLGTGLHYRSVSEAFAGELADDGYLGRTSTGDDEEELIVDEDHQQDFGRKDGRAWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L682</accession>
    <name>A0A367L682_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_8614</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI09931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L682"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="523"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="565"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI09931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="760" mass="84646" checksum="864D647B21FF510D" modified="2018-11-07" version="1">MSMFLYLIGESNGMQTRYPSDLALAWQQQQQQQQHVIRSHRRRQTRDSRFALDDNQTSFHWLFLILLALYSNKTDIHTYTTDFFPLRSSPPVRQRGKKKKLSRQLALPPPPPRGPSPPSTTTTNDQTSIISRRVSDRQGGAEFCPGPTGQSHRPVPPTTSWIVELYFDVCGGVEETRPKGSLVRFGSEARARPPDDHLHPHRSRRRTRLTLEEADSSPAANVTPEMLLDEARWRDARAPWTMPGDEAAGSRRARPSSPDGGPRRETKTKDSILFRVMWEVREAILRRGGASAGENGEESTQLREVPAGPLPSLLIRFSAPFRKAWGWTGGTRSPWGYATRPVVPRVQEVKTTALEPGTGLPWLYMVDEPDGSHWPSSSSGHLLIWRAPAHDYKFLPFFRPAHDSFPSFFFFPLPPSPSYRPFFSLDSFGFALPSHYSCPLLSSPPSSSSSSSLFTSPLVTPPFWAGEWQHSPAPRFCSPVDVSDAVALDGAELARRSRPLGTSGQDDAHLIVLLPNARGFPRWAFGPFCLIVCFFFSLVFCFFFLPVCGEKFFTSPPYTSALSPTSSFFFFPLPSSLFLFLFLYHHHPSSSSPSSFINTILLNHPHPSLSSTTILLHHHHPPSSSPSSSITLLLHHPPPPPSPSSSIIILLHYPSSSSPSSFIIILLHHPPPPSPSSSITLLLHHHPPSPSFFIITFLLHHHPSSSPSSFFSPSFFIILLHHHHHSSSSTTIPSSHLSSTITGQHRLPSGIFLSLPFPSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6I5</accession>
    <name>A0A367L6I5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8699</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6I5"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="117" mass="13431" checksum="D72F4175D5A5C158" modified="2018-11-07" version="1">MVVFSKEVGASPPPSRHPSSLEGYRHHHHHHHHHHQPSDLTSARLTPSPHCSPSLKPVHHVMLDNHQSDDDDDDDDDGHQDEDEDDNHRWNPCHQWQALNLIPLDPRWAFDTLKGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6J8</accession>
    <name>A0A367L6J8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell wall protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6J8"/>
    <dbReference type="STRING" id="1330021.A0A367L6J8"/>
    <dbReference type="OrthoDB" id="2422134at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021054">
        <property type="entry name" value="Cell_wall_mannoprotein_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38123">
        <property type="entry name" value="CELL WALL SERINE-THREONINE-RICH GALACTOMANNOPROTEIN MP1 (AFU_ORTHOLOGUE AFUA_4G03240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38123:SF6">
        <property type="entry name" value="CELL WALL SERINE-THREONINE-RICH GALACTOMANNOPROTEIN MP1 (AFU_ORTHOLOGUE AFUA_4G03240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12296">
        <property type="entry name" value="HsbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016603647" description="Cell wall protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="178" mass="18743" checksum="262B375F32A801A9" modified="2018-11-07" version="1">MKFSVQLVLAVLATAVSATPLIVQRDFNSISKVISDVQTKLDAVAASVSKDDTEGTLSSGKALISACQAGTSEVKKSQELALSDTAKLLGPVGTLKQHGQKLHDDFISKRGKIEGRKMCGKAREMLGQFSSSAHELIEAIISKVPQASRGIASSTAKEITDLIDDIKANFGPDKCKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6V6</accession>
    <name>A0A367L6V6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Proteasome component ECM29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_8589</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI09952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367L6V6"/>
    <dbReference type="OrthoDB" id="16066at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024372">
        <property type="entry name" value="Ecm29_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055443">
        <property type="entry name" value="HEAT_ECM29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346:SF19">
        <property type="entry name" value="PROTEASOME ADAPTER AND SCAFFOLD PROTEIN ECM29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR GCN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23731">
        <property type="entry name" value="ARM_ECM29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13001">
        <property type="entry name" value="ECM29_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24492">
        <property type="entry name" value="HEAT_ECM29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Proteasome component Ecm29 N-terminal" evidence="5">
        <location>
            <begin position="14"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome adapter and scaffold protein ECM29 HEAT-repeat" evidence="6">
        <location>
            <begin position="1283"/>
            <end position="1439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI09952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1836" mass="202802" checksum="28705DDED9946D03" modified="2018-11-07" version="1">MASPSTEQRELQLVESVDFKILAVANKEDKLHELLQRYLVPLILKADSPRASVRTKVIEILARLKTFIQPPTIILPVNELLKQYKSCTSPIVQQLDLSFIQHSLERLDADERTQLIPLALRGISAENDRPSAPGMLNIALRLLHDADIPPRGSQEDDAFKEAIGLSDDADAEFLANAFRVVFHLRMPSHGLALEFFNPTLSAPELALFSMERAEIERLFDHMSQLRVKLVSLLASGAFTDKQKLVPAVCAAAGHDNRAAAAAEEIIKRSSVSLEDEGLVKRLFEVYLNSLPVIRTRVLGILSKSALSTTMTEQITMVIDRDICQRNFPHQWWPPTTAPELLKLQNALFHYLTWVAHTGPSRPPFIVGSHLLKSMQEYLTLVGWPIPNANKPGAAYQHGKAYEIIGMLGRTADISTSERIKVAMWLFRSLVLDPTDGIVVSIDGALSGMSTSIPPSIGSDDEELKVTLLLLMLPPINERLPTVRSARHAVVKWANQCLLFTDILARLIDILAISARRDEPRDVIEQGMRGLDPWANSLPGEPSSPLPDWREMIRVFQSPDDQLCNALFGRCNVTTRRALAGFVAFNEKLPLVATAALRFCRLIMFLTALIGSELYPDSLQALERQLQNDIGTRNKVRAYLESTDVTTPALSYLKWCLSNVRLSPAVEASMQCFVDVASLSSRSNVGTVISTADESKMLLDLVKSNDKKVSSMAAKAVGITLAHPVHDAKDVAKWSSELASSWTLATQLSGPKLSACEGGLRAFAHLRSRAVYYGRHFPTDIEYQFHLLVNEYSSSSLYEAALYAFSELWTAGLASPSTDGDFSVGKIVEKLSAQAKKGNEQAVAALGRLAMVIEDAEDMELVVAENGFVAPSGGMLAIILNELFSLHEFGQIELQFTVGEAIVAAVARWESDKIVNSLDVVPAEVPAKRFGPARGTALEAVIKKLLRGCKATKPSLLRSSGIWLLCLVMNCSNLDTVQSRLREVQAAFMRLLGARDEIAQETASRGLSLVYERGSDDLKAALVKDLVGAFTGSGTQLKVDNETELFDPGALPTGEGQSVTSYKDIVNLANEVGDQRLVYKFMSLAADAATWSTRSAFGRFGLSSILSEAEVDPKLYPKLYRYRFDPNTNVQRSMDAIWKALVKDSSATVDKHFEAIMQDLLKSQLGREWRVRQASCAAISSLISGRPFAQYGERYKDIWTGALKVLDDVKGSVREAALRLCMALSNGLVRQLEDGGHSAAANAMMKEALPFLLSDKGVENSAKDVQAFATITLLKVAKKGGQALLPFIGEMVTQLLGLLSIIEPEQINYHYQRLGEEGRDKIDRIRSQMVNQSPISEAIEDLLRFVDTSIMAQMRPKLDDTIKTAVGMPTKIGCSRVLTTLATRHASLLDSTHFLNLLQKQVLDKNDEVSQAYARAAAYIWRAAPEETQIQFCEGFVDKYLRAENEHRRQKIADVIVALAKISPDHFGAHETVLLPLTYVGCHDTDEYTAKMFQEAWSQHVGGGRTVMRYVREIVALVEKCMDTTQWSLRHTAAFTAAALAMDVSNAADAAGGMGEPTARDIWLALSKTLALKTFPGKEKLLESFPRFVEQSRALWGADEAVAAQMKQIAVREAKRNNDEYRVHAFRCLWRFAKTRDDIDMTQEIRAITRPYLEAQNDGDRMDVDSKEDLTFTTAKSALEAVARGYPESKVTDFGKVLEGMVSSLKPFLSSSRFDVIRREVWYGCVCDLMKDATKMTSPMSPQLQDGSTTLASLLESLDMDQAEVGTEAQRLTRAKAAEAAIRAKTDGVFGRVSISKEVREAVASALARERSFDVQKLWRAVMEAIEEATRQDSKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6W1</accession>
    <name>A0A367L6W1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cleavage and polyadenylation specificity factor subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer (via N- and C-terminus); binds RNA as homodimer. Component of the cleavage factor Im (CFIm) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Nudix hydrolase family. CPSF5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6W1"/>
    <dbReference type="STRING" id="1330021.A0A367L6W1"/>
    <dbReference type="OrthoDB" id="277288at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18871">
        <property type="entry name" value="NUDIX_Cfim25_Nudt21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000005">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016706">
        <property type="entry name" value="Cleav_polyA_spec_factor_su5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13047">
        <property type="entry name" value="PRE-MRNA CLEAVAGE FACTOR IM, 25KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13869">
        <property type="entry name" value="NUDIX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017888">
        <property type="entry name" value="CPSF-25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR017888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="262" mass="29631" checksum="7E841CFC53FFF419" modified="2018-11-07" version="1">MSTIPPSGLKSGHPPIIPLSFSSRQPEKVTLYPLSNYTFGVKETQPEEDPSVLARLKRLEEHYAEHGMRRTCEGILVCHEHNHPHILMLQIANAFFKLPGDYLRPEDDEIEGFKARLDERLAPVGRIGEGEEAGNWEVGECLAQWWRPNFETFMYPFVPAHVTRPKECKKLYFIHLPQTKVLSVPKNMKLLAVPLFELYDNTARYGPQLSAIPHILSRYNFEFKDENGNVAAVTPGMEGYVPKTKVLSGDDADMKDGGENGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L704</accession>
    <name>A0A367L704_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">L249_8663</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367L704"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097435">
        <property type="term" value="P:supramolecular fiber organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000104">
        <property type="entry name" value="ATP-binding cassette sub-family F member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000882">
        <property type="entry name" value="Translation initiation regulator (Gcn20)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000003">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000009">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002358">
        <property type="entry name" value="Ribosomal_uL6_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF117">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00525">
        <property type="entry name" value="RIBOSOMAL_L6_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="17">
        <location>
            <begin position="443"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="17">
        <location>
            <begin position="775"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="184"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="367"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RCI10188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1837" mass="202384" checksum="9AB1C25DDDAD2D65" modified="2018-11-07" version="1" fragment="single">VSPILAARLDSPPAPRLTTRAGPIAESSESPMYMQTLHLSLLINSSSSASFPLLIHVSGVALTNALSVEYGLDDAAGGHVRQRNQGSMRLLVCSCASTCWFVTDPNSQQPLSAGLLNPLNRRFVSYAPSAATPSRIGPRGICSWPSENHVTVPNADVLFAQHQLSHARIGIGCCEDCAPKIVPGPRKRNRDNHSSITGAFARLRQRRREEDREARVSKSQQDDSFEIRLSTPAVGQPTSGGSTRAMDADIRAVLPNIDPVITNYSAGYLSYASTAWAGDEDSSGLSPLAEAAAAITELLLSASGRVDAACEKSIKQVVEKWVDRYAAENGGQQTGPQIVKRLDQTIQVSTQRNMSSTLAVASGGVDLESANARKVESKVDRKKLEKAERKIAAKQQKKTYKTVEYEASRLLEQPESTQSYDEFYMAVNPLQLGGSGANKTKDIKLDSIDVSIGGKRILTDTSFILAFGHRYGLVGNNGVGKSTLLRALSRREVAIPTHISILHVEQEIAGDDTPAIQAVLDADVWRKVLLKEQQQLVADLADLEVRRAPLADTSADAAKLDHEKEVKDGKLGDIQAKLAEMDSDKAESRAASILAGLGFSTERQQHATKTFSGGWRMRLALARALFCEPDLLLLDEPSNMLDVPSITFLSGYLQNYPSSVLVVSHDRAFLNEVATDIIHQHSERLDYYRGANFDSFYATREERKKVAKREYETQMAQRAHLQAFIDKFRYNAAKSSEAQSRIKKLEKMPVLEPPESEYSVKFRFPDVEKLSPPIIQMSEVAFGYSKDKPLLSNVDLDVQLDSRIGIVGPNGAGKTTILKLLIGKLEPLKGLVTAHARLRIGFFAQHHVDALDLTMSAVSFMAKTYPGRTDEEYRRQLGAFGITGTTGLQKMALLSGGQKSRVAFACLALTNPHILVLDEPSNHLDIEAMDALAEALNEFQGGVLMVSHDVTMLQMVCTSLWVCDGGTVEKFAGDVQQYKKRIAAQADAAGVALSIAVGRWTRVMMVLAPQRWTLSPPLACHMLRLLTSFFLFGDGQVHLQTGQCAPFLALTRFQQGNQIGAAFWQTISGEHGLDSNGVYNGTSELQLERMSVYFNEVSHPSAQRPMQNLILCEKQKKKASGNKYVPRAVLVDLEPGTMDAVRAGPFGDLFRPDNFVFGQSGAGNNWAKGHYTEGAELVDNVLDVVRREAEGCDCLQGFQITHSLGGGTGAGMGTLLISKIREEFPDRMMATFSVVPSPKVSDTVVEPYNATLSVHQLVENSDETFCIDNEALYDICMRTLKLSSPSYGDLNHLVSAVMSGVTTCLRFPGQLNSDLRKLAVNMVPFPRLHFFMVGFAPLTSRGAHSFRAVSVPELTQQMFDPKNMMAASDFRNGRYLTCSAIFRGKVAMKEVEDQMRNVQNKNATYFVEWIPNNIQTALCAIPPRGLKMSSTFIGNSTSIQELFKRVGEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATIDDEREEYDEGQAEEPEEYLLLLMACWPYRSSPQKNPMRTIPHSNVNYVIDLRLLRAYIYLLSHPRSPTIWRVPQFNGDNDGLLAGGTPFAADGSSSCCGGGTITTFLGDSATGVEAGTHAYLPAAGGGSDDHCQGRAGWASSFPRWRMASSLNWVADLRGGPMMVGTLKLDIPRYMTMSQNAENKTVSLGIENSNERRQKEMWVSLGIENSNERRQKEMWGTTWAYLNNHIRGVSEGHTAILRLVGVGYRAIVSARRSKEEYPGQRFLCLKLGFTHPVEEGIPQGVKVSTPTPTRILAEGPDREALMSFAGRVRKWRPPEPYKGKGVFINDQTIKLKAKKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L749</accession>
    <name>A0A367L749_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">diacylglycerol O-acyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">L249_8523</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>an acyl-CoA + a 1,2-diacyl-sn-glycerol = a triacyl-sn-glycerol + CoA</text>
            <dbReference type="Rhea" id="RHEA:10868"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:64615"/>
            <dbReference type="EC" id="2.3.1.20"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the diacylglycerol acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.20" evidence="5"/>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L749"/>
    <dbReference type="STRING" id="1330021.A0A367L749"/>
    <dbReference type="OrthoDB" id="264532at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07987">
        <property type="entry name" value="LPLAT_MGAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007130">
        <property type="entry name" value="DAGAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317:SF0">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03982">
        <property type="entry name" value="DAGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="392"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="392"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="432"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="487"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="504"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RCI10256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="516" mass="57984" checksum="E70A7CF39EF17ED9" modified="2018-11-07" version="1">MTNSQSKTQSSDDDQATVRLQPRYPDLKDVGSHGCHECAAWKAGGIRFVPLQIPWTRRAQTAALLFHCTAFITMSSVFLVGCVVPVAWPVVVPYLLYLLLSTAATDGSLSGRSEWMRSLKLWELVAGYYPMKLHKTQDLPSDRRYIMGYHPHGIISHGAWCAFATNALGFARKFPDITNSLLTLESNFRIPIYRDWILAMGMRSVSKESICNLLSKGGPDNKGQGRAVTIVVGGARESLEAHPGKLRLVLKERKGFVKLALRTGADLVPVIGFGENDLYDQLCPETHPIVHRLQQTVLKVFKFTIPALHGRGLLNYDYGLMPFRRQVNVVVGKPIRVDRAYEKPAQEVIDKYHHLYIEELTRLFEAYKLFTLLVVDLSGRLPKENNIDDKLEHIASRRKPEPHGQYPVRPGEPPRHHGLLSTVGPYQPPDEDFLKSQDGNHHGEEEPCQVAQQLYQDGVPIKSESDGAEENPGRHEYHANDNPCRSLSHDHDGIHPGRPRQDIADADAVEWVDDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7I9</accession>
    <name>A0A367L7I9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HNH nuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7I9"/>
    <dbReference type="OrthoDB" id="4928181at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="243" mass="27465" checksum="7FAD5C854F15E5A1" modified="2018-11-07" version="1">MTHYDERIELARQVVENIKIEVPDSTRPWNQWRKKPVYYYKKPMRTVKSLIPRPEFRHIIFHALSVAPGFPQSCFRISRESLWGNPGVTDKAWNMICLSPLLHRFWATATFAFKLPALPGGTVPVQLQFRVASPNTPSTFTNCRTTRFLDGVDDENLTTLICFNTTGKQVLSGHIFTALIPTEDVERFFLMINIQWAQCQLAGMIAAAEALQDEGDKDEDDGEADVELDSLMEGLSVSESGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7Q2</accession>
    <name>A0A367L7Q2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">NADH-ubiquinone oxidoreductase 51 kDa subunit, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">L249_8558</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29091"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="7.1.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="17">Complex I is composed of about 40 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="15">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I 51 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7Q2"/>
    <dbReference type="STRING" id="1330021.A0A367L7Q2"/>
    <dbReference type="OrthoDB" id="42889at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.230:FF:000001">
        <property type="entry name" value="Mitochondrial NADH dehydrogenase flavoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.600:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11540:FF:000001">
        <property type="entry name" value="NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11540">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.230">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050837">
        <property type="entry name" value="ComplexI_51kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001949">
        <property type="entry name" value="NADH-UbQ_OxRdtase_51kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011537">
        <property type="entry name" value="NADH-UbQ_OxRdtase_suF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011538">
        <property type="entry name" value="Nuo51_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037225">
        <property type="entry name" value="Nuo51_FMN-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019575">
        <property type="entry name" value="Nuop51_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037207">
        <property type="entry name" value="Nuop51_4Fe4S-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008733">
        <property type="entry name" value="PEX11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054765">
        <property type="entry name" value="SLBB_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01959">
        <property type="entry name" value="nuoF_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010120">
        <property type="entry name" value="PRK13596.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11780">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE FLAVOPROTEIN 1 NDUFV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01512">
        <property type="entry name" value="Complex1_51K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10589">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05648">
        <property type="entry name" value="PEX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22461">
        <property type="entry name" value="SLBB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00928">
        <property type="entry name" value="NADH_4Fe-4S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142019">
        <property type="entry name" value="Nqo1 FMN-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142984">
        <property type="entry name" value="Nqo1 middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140490">
        <property type="entry name" value="Nqo1C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00644">
        <property type="entry name" value="COMPLEX1_51K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00645">
        <property type="entry name" value="COMPLEX1_51K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="NADH-ubiquinone oxidoreductase 51kDa subunit iron-sulphur binding" evidence="20">
        <location>
            <begin position="369"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="642"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00063883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00072764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RCI10262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="729" mass="79442" checksum="DDD3D4D7D56D439F" modified="2018-11-07" version="1">MLSSKASPSRAVGLSRTAIRGLATVEDGTPKRTHGGLKDQDRIFQNLYGRYPADLKSAKKMGDWHRTKDILLKGYDWIIGEIKASGLRGRGGAGFPSGLKWSFMNVKDWDKDTKPRYLVVNADEGEPGTCKDREIMRKDPHKLVEGCLVAGRAMNATAAYIYIRGEFVYEAAVLQNAINEAYKDGLIGVNACGSGYDFDVYLHRGAGAYVCGEETSLIESLEGKPGKPRLKPPFPAAVGLFGCPSTVANVETVAVAPTICRRGAKWFASFGRERNQGTKLFCISGNVNNPCTVEEEMSIPLRELIDKHCGGVRGGWDNLQAVIPGGSSTPILPKSVCDDQLMDFDALKDSQSGLGTAAVIVMDKSADVVRAIARLSHFYRHESCGQCTPCREGSKWTEQIMSRFEKGQGREREIDMLQELTKQVEGHTICALGEAFAWPIQGLIRHFRPELEARMQDFQKRSGGPALAGGWEHRTRAEGKLVSPDMASLMQQFTAFGTDIVGLERFLRLIQATLLTLSSYPALLANEAKAPALQQLQWRLNLSRRTLRLFWFLGSFDAGVARSSSDGWLGVLAQSALGIFGLVESVTLLDLVGVDGVAIWGAEEAWRLDREAQVLWLVGLCADALTCALRLRSISSARGGASSAEEKKATTKKRERKSPMPSDGDDKIAELTSRLVADLLDALIPASSIGYVSIDDGLVGIAMVCSTLLTATTVWNRCRSQLVRADKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7T1</accession>
    <name>A0A367L7T1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_4459</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7T1"/>
    <dbReference type="STRING" id="1330021.A0A367L7T1"/>
    <dbReference type="OrthoDB" id="629492at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045862">
        <property type="term" value="P:positive regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46803">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46803:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CHIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI10487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="205" mass="22964" checksum="508833B8920C9FC6" modified="2018-11-07" version="1">MLPWHPGFFSLSFNQKAEGTVLHQRLLTSSHRQLSVDFRPETAMGREGASPDMSRSTQLKEDGNRRFQAGDFTGADSFYSKAILADPKSPLLFSNRAMARVKLGLWESVIDDCNACLALAPSSFKAYYYLAQAQSALADHDAALDSARRAHDLCVASGDRSLAAVTAIVLRCKRDRWEHRERHRRRGAGELELELAELLRRQTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7V6</accession>
    <name>A0A367L7V6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dolichyl-phosphate beta-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.117</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_4336</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-alpha-D-glucose = a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate + UDP</text>
            <dbReference type="Rhea" id="RHEA:15401"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:15402"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.117" evidence="4"/>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7V6"/>
    <dbReference type="STRING" id="1330021.A0A367L7V6"/>
    <dbReference type="OrthoDB" id="3784at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004581">
        <property type="term" value="F:dolichyl-phosphate beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04188">
        <property type="entry name" value="DPG_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035518">
        <property type="entry name" value="DPG_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859:SF91">
        <property type="entry name" value="DOLICHYL-PHOSPHATE BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859">
        <property type="entry name" value="GLYCOSYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="13">
        <location>
            <begin position="87"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI10508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="364" mass="40036" checksum="B54FEFCB5F175037" modified="2018-11-07" version="1">MESISWPIILIGCLVAILPSAFSLLCRLAPQPRRVFDSEKSFVTIGSDGKTTTQVLSCWYDRWVAERRLDAESLSPDAIEPAEVHLSVVIPAYNEEKRIIPMLEEAVTYLDEHVGRSPSSRPGRGYEIIVIDDASSDSTVDVVLDFSRRKQLHDVLRVVSLAKNRGKGGAVTHGFRHVRGAYVLFADADGATRFSDVQKLLEGVDHVAKASGRGVAIGSRAHLVGSEAVVKRSALRNFLMRFFHRVLTILTPPATSRLRDTQCGFKLFTRAALPHIVPYMHAEGWIFDIEMLMLSESAPAAPIRAADGSVIGSSPGIKVAEVPVHWHEVGGSKLNVVQDSIKMAIGLVVLRASWMLGVYRRRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L862</accession>
    <name>A0A367L862_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Altered inheritance of mitochondria protein 41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="primary">AIM41</name>
        <name evidence="4" type="ORF">L249_4414</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L862"/>
    <dbReference type="STRING" id="1330021.A0A367L862"/>
    <dbReference type="OrthoDB" id="506498at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016884">
        <property type="term" value="F:carbon-nitrogen ligase activity, with glutamine as amido-N-donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1510.10">
        <property type="entry name" value="Uncharacterised protein YqeY/AIM41 PF09424, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003789">
        <property type="entry name" value="Asn/Gln_tRNA_amidoTrase-B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023168">
        <property type="entry name" value="GatB_Yqey_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019004">
        <property type="entry name" value="YqeY/Aim41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042184">
        <property type="entry name" value="YqeY/Aim41_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 41, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28055:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 41, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09424">
        <property type="entry name" value="YqeY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89095">
        <property type="entry name" value="GatB/YqeY motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="3">
        <location>
            <begin position="76"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI10422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="503" mass="56638" checksum="B58EC98F78EBCF1F" modified="2018-11-07" version="1" fragment="single">PLDERLTETVEFLGRTYQKYALENGVYFAPIDEASRPYSKGVALEEVSRLELMHSVLRKVFDDRLIFPPVNSPRRILDCGCGSGDWAVDVARRFPDCEVLGIDISPHIMPEDGPNNLEFQIDDLNGRFTFPSDYFDLVHSQMVAGGIHSTRWRSYIQDMIRVLRPGGWCQMVEVYFNAQSDNGTLERDHALSEWSREYLDTMHRQKDPRAAMHLASWMRSEGFTEVESRLLTLPMCAWPSEAREQGIGTANSENVAQLLYSLGLYPLIQLRGLELEPHITSREASYGKNLQQQQTEQRSSSPTNIHPSIMLIKPPRLASCARILHQVTRRNAPFTSRTFSSLNEPNTSPPLYQKIRQEFKSAMRSGDKPRLNALRSIMTANTNAAKADRPITNDVQLINLIRNLYRMSSEAATQAKDNDRPELAAQEEEQMEIYSNLIANSGVETLDEAKLKALVGDAVAASKSAGTVAKKLMGDVMKRLSGAFEGKDVDMKLVARLVQEMAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L947</accession>
    <name>A0A367L947_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AMP-activated protein kinase glycogen-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5316</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L947"/>
    <dbReference type="STRING" id="1330021.A0A367L947"/>
    <dbReference type="OrthoDB" id="5422351at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40625:SF1">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE GLYCOGEN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40625">
        <property type="entry name" value="GTP-BINDING PROTEIN ESDC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI10951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="43853" checksum="05BE2FE2B543679B" modified="2018-11-07" version="1">MDPNTTLVTFLLQTDASVQSVNLIGSWDGFSACYPMKPDFRRGRGQWRGCHSFKDIICDDDAAVPRRDGGLKMGATYYYYYEVDGCVETYDPAEPTTTACPYLPGQTVNTLSVPVERPERHRSASLNSLHAERFKTMDPEAKFATPCPPAVTVAAETAAARRLLSAPGIPRALLPAPPPSWKRFFSRKSSCRASDDGSDLSTPPSPTGLVAVGDVSHHESLRRFLPAEDSYGSVTRPMAIPEDIAEEAAADDSFASLTLTENDSSVASASLLPIRSCASSDVMAKTRLMAAPSPSGSLNRMEASPRQTRWSALTPVEDDPPSFYDSYDEDEVLSSNDGDNFSHAPLPSLSSSAERAFKVYSLPRQADEVKGAPSLRSPRLLARTDSGLDELVSELGWMVDVIGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L949</accession>
    <name>A0A367L949_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enolase-phosphatase E1</fullName>
            <ecNumber evidence="6">3.1.3.77</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">2,3-diketo-5-methylthio-1-phosphopentane phosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">UTR4</name>
        <name evidence="7" type="ORF">L249_5312</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="ChEBI" id="CHEBI:58828"/>
            <dbReference type="EC" id="3.1.3.77"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 3/6.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 4/6.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.77" evidence="6"/>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L949"/>
    <dbReference type="STRING" id="1330021.A0A367L949"/>
    <dbReference type="OrthoDB" id="272500at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00876"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043874">
        <property type="term" value="F:acireductone synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01629">
        <property type="entry name" value="HAD_EP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03117">
        <property type="entry name" value="Salvage_MtnC_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023943">
        <property type="entry name" value="Enolase-ppase_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027511">
        <property type="entry name" value="ENOPH1_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01691">
        <property type="entry name" value="enolase-ppase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20371">
        <property type="entry name" value="ENOLASE-PHOSPHATASE E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20371:SF1">
        <property type="entry name" value="ENOLASE-PHOSPHATASE E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01133">
        <property type="entry name" value="C1.5.4:_Enolase-phosphatase_Li"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="127"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI10947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="251" mass="27376" checksum="2FA1501C03AFECD6" modified="2018-11-07" version="1">MASMDAVDVLLLDIEGTVCPVSFVHDVLFPYALDSLPGHLQHHWDSPDFASYRQAFPQHCRDDRVAFEALVRQLMAKDVKEPYLKALQGYLWQKGYRSGQLEAPVFPDVAPFITAAHAAGKTIIIYSSGSVAAQKLFFSHTSAEPSNLTPYISAWFDTVNAGPKTETASYATILASSPNIAPARWLFLSDNIHEVRAALASGMRSLPVVRPGNTSLPPDDPLSKLAICDFSPKSFDSIEPSLATLRDMAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L993</accession>
    <name>A0A367L993_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5438</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L993"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI10989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="99" mass="11624" checksum="FD90517C8FEEBABB" modified="2018-11-07" version="1" fragment="single">KSPIFRGYKKTQKVIQAVDKELTNREGDHVIEKKKRNHKVRKADANNSSKYFSRYFKVPTCSTLTYLYKIGDLEEDLYVPYPAVSAVLRGVWVRIRPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L999</accession>
    <name>A0A367L999_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5437</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L999"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI10986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="48" mass="5474" checksum="AE09CBAB7BFAFBB4" modified="2018-11-07" version="1" fragment="single">RGRVRTYRGYSGRVIAVIAGVIGLPLNRRSSKVLQVGTLKYLDKYLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9N4</accession>
    <name>A0A367L9N4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Calcium-transporting ATPase</fullName>
            <ecNumber evidence="16">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">L249_7282</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the hydrolysis of ATP coupled with the transport of calcium.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>Ca(2+)(in) + ATP + H2O = Ca(2+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18105"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Sarcoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15 16">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="16"/>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9N4"/>
    <dbReference type="STRING" id="1330021.A0A367L9N4"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02083">
        <property type="entry name" value="P-type_ATPase_SERCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000003">
        <property type="entry name" value="Calcium-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000005">
        <property type="entry name" value="Calcium-transporting ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000037">
        <property type="entry name" value="Calcium-transporting ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000014">
        <property type="entry name" value="Calcium-transporting ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000065">
        <property type="entry name" value="Sarcoplasmic/endoplasmic reticulum calcium ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005782">
        <property type="entry name" value="P-type_ATPase_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01116">
        <property type="entry name" value="ATPase-IIA1_Ca"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 16" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 16" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13 16" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0703">Sarcoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 16" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="289"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="821"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="889"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="920"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="17">
        <location>
            <begin position="3"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RCI11128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="998" mass="107919" checksum="3A5A8150E9E0AEFD" modified="2018-11-07" version="1">MENSFARPIAAVLAEFDVDEFKGLNDKQVQQLRRKHGRNAIPEEPPTPIWELILEQFKDQLVIILLGSAAVSFVLALFEDEGGWSAFVDPAVILTILILNAVVGVSQESSAEKAIAALQEYSANESNVVRNGGHVARLKADELVPGDIITVSVGDRVPADCRVVSIESNSFAVDQAILTGESESVGKEQVVVKDMSAVLQDQVNMLFSGTTVVIGRARAVVVLTGPNTAIGDIHESITAQISEPTPLKQKLNDFGDSLAKVITLICILVWLINIPNFNDPSHGSWAKGAIYYLKIAVSLGVAAIPEGLAVVITTCLALGTRKMAAKNAVVRSLPSVETLGSCSVICSDKTGTLTTNQMSVSKVVYIDDQGTDLVELDVEGTTFAPSGAICMGGQAVDDLPSKSDTVRQMAEVAALCNDSHLAYDSRTATFSTVGEPTEGALRVLVEKLGPSPPAGTHPDDCVHFASAKYEERLPRLATYEFSRDRKSMSVLVKSGKQKKLLVKGAPESILDRCTHALAGPDGKRVALDGKLSDLVMKEVVEYGDRGLRIIALASIDDVSKSPRLSAKTTAHYAELEQSMTFLGLVGMLDPPRAEVPGSIKQCKKAGIRVIVITGDNRNTAESICRQIGVFGPQENLKGKSYTGREFENLSPGEQLKAAKRASLFSRVEPGHKSRLVDLLQSIGEVVAMTGDGVNDAPALKKADIGVAMGSGTDVSKLAADMVLADSNFATIEVAIEEGRAIYSNTQQFIRYLISSNIGEVVSIFLTAALGMPEALIPVQLLWVNLVTDGLPATALSFNPPDGDIMKRQPRKRDEPLIGGWLFLRYLIIGTYVGIATVAGYAWWFMYYASGPQITFKQLSRFHHCSTEFPEIGCGMFTDERARAGSTMSLSILVVIEMFNAMNALSSSASLLTLPLWKNMMLVYAIALSMALHFALLYTPFLQSLFAILPLNREEWNAVVILSAPVILLDEVLKFFERRFFMQTATHVAAPIRIDKKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAG1</accession>
    <name>A0A367LAG1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">H/ACA ribonucleoprotein complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_7241</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Non-catalytic component of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP), which catalyzes pseudouridylation of rRNA and is required for ribosome biogenesis. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs. The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs. The H/ACA snoRNP complex mediates pseudouridylation at position 93 in U2 snRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9 10">Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
            <location evidence="1 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 10">Belongs to the GAR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAG1"/>
    <dbReference type="STRING" id="1330021.A0A367LAG1"/>
    <dbReference type="OrthoDB" id="2187159at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034513">
        <property type="term" value="F:box H/ACA snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000454">
        <property type="term" value="P:snoRNA guided rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.230:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237:SF6">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237">
        <property type="entry name" value="NUCLEOLAR PROTEIN FAMILY A MEMBER 1 SNORNP PROTEIN GAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="123"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="134"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00053712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI11232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="202" mass="20676" checksum="4C2A6BA4662E7C05" modified="2018-11-07" version="1">MSFRGRGGGFGRGGFRGGRGGFSAPTGPPAEVLEMGLFEHAVEGEMLCRSSNVKVPYFNAPIYLENKTPIGKVDEILGPINQVYFTVKPQEGIVATSFKAGDKVFIGGDRLLPLDKFLPKPKVVGEKKVKKPGGGRGGRGGPRGGGFRGGMSRGRGGPRGGGGFSRGGGRGGFSRGGPRGGGGFSRGGGGRGGGFRGRGRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAM2</accession>
    <name>A0A367LAM2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cysteine synthase 1</fullName>
            <ecNumber evidence="5">2.5.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">O-acetylserine (thiol)-lyase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">O-acetylserine sulfhydrylase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">O-succinylserine sulfhydrylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">L249_7199</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Catalyzes the conversion of O-succinyl-L-serine into cysteine, the last step in the cysteine biosynthesis pathway. Can also use O-acetyl-L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>O-succinyl-L-serine + hydrogen sulfide = L-cysteine + succinate</text>
            <dbReference type="Rhea" id="RHEA:53816"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:136856"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="5"/>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAM2"/>
    <dbReference type="STRING" id="1330021.A0A367LAM2"/>
    <dbReference type="OrthoDB" id="10259545at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000011">
        <property type="entry name" value="Cysteine synthase (o-acetylserine)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007989">
        <property type="entry name" value="PRK10717.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 22" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="24">
        <location>
            <begin position="26"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="93"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="246"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="559"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="23">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="367"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00050981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00058228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00072087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00078262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00079147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00081847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="RCI11463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1153" mass="126997" checksum="8C0909269C4284C8" modified="2018-11-07" version="1">MEPPRKPSLDLEKELTCSTDDRAAQICTELLYQPLTLLDCLHTFCGACLKEWFGFQALTTAPFTCPSCRSAVRGSRHNATVVTLLDMLVAAQPGKARSQADKDEMARKYQPGDEVPPKVAAGRESKKHDDDDDDERLLEQVREMSLREALTPRRRNERNERSQEDEHQEEGEGEEEGEEEEEEEERRRRQVEHQSSLRSLIGSAERDIEREIEDFARQIQEEGLLDGLDLDNIDLSRDDELSRRVTEAYRRRQRRGRSQRQDEAATTRRHRATSSSNRSGPPSASLEVRGVRSRRRTASGGRSATAPLLSVGGAAQQQAARSQTELVPSRLDVPAAAARDQRRSSSTPSVAAFAPPAGGGGGRGGESNASFASRAPQWNPTTDSRTDAQPVSRNRPQLYPEPSISCSRCSRRHIEYELHYSCALCAGGQWTVCLDCYRAAKGCLHWFGFGHGAWIKWDKAHQLDPTTARPHVLTASRYLRPPSIPGGADGRRTLTWHDPRTRLETGTFCARCLVRANECYWRCDVCNDGDWGFCTDCVNGGLSCSHMLLPLAYEPTTLSQQEQQQEQASKQPIPGLRRQWTGRPQSSLGPFKPLPVYSDAICAVCQESMAASQVRYHCFTCFKGYYDVCPRCYSSLETQGKISAENGASGWRRCLGGHRMAVIGWASGKVGRWRYVEREPVGGRSLVEGGGAGNAHDGTELWSWPSASETRRRRVTVDVAASTGAGVGFPPDGGLGMRAQARWAWYPAAGADDELLFPRGAEVREVEDVNGDWFFGVHHDSFDNMFRHSARRLTQQSANACLGNRIAVSHAQGITPGFTGAIGNTPLIRLQHLSEETGCTILGKAEFMNPGGSVKDRAALWIVREAERRGELQSGGTVVEGTAGNTGIGLAHVCRARGYKLVIYMPDTQSQAKVDLLRLLGAEVYPVPAVPWDNEENYNHQARRHAARVQGAVWTDQFDNVANRQAHIDSTGPEIWAQTGGKMDAFVCATGTGGTLAGVTRFLKEKSGGAVRCYLADPPGSVLYSVITSDGKSKERTGTGSITEGIGQGRVTENLKPDLELLDGAFHVPDEETIAMVYRCLDEEGLYLGASTALNVVAARDVARKLGPRHTVVTILCDGAYRYADRLFSRSWLAEKKLLDAIPKPLQRYIALP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAN7</accession>
    <name>A0A367LAN7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAN7"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="131" mass="14750" checksum="45FD4880F73D8F0F" modified="2018-11-07" version="1" fragment="single">PKARHNALSHSGAIAVIAPDRLVTAIVTAIGALRHIDRRAILIAVIALDQSSQRNRHSDRRAVLIAVIAPDLDGRTKFIISFNFITSLIQSPLLPSILLQSSQNHHHVIRLLLLYHVIYTLITHYYFHCRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAX7</accession>
    <name>A0A367LAX7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_7161</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAX7"/>
    <dbReference type="OrthoDB" id="289247at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040250">
        <property type="entry name" value="Nucleobindin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19237">
        <property type="entry name" value="NUCLEOBINDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19237:SF20">
        <property type="entry name" value="NUCLEOBINDIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016677703" description="EF-hand domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="98"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="178"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI11580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="211" mass="24647" checksum="E63387B74EE238CA" modified="2018-11-07" version="1">MRASLFSSPMVFALLAEAVVANDAQKPLVKEADWMTKHMAGKSGLYFFRLEEHHITTWDSESFFSLHDYNADGVWQVDEVQRTYGLMDPSNKDMPRQRKEQVTRDVMAMLDTDGDSVVTLAEWKAFLAKGKTLPDMGTGPGHHGDDEYEYEIHHWEKYHDEHTKLEDLTHPEDIEHFKQHEEREKAQETQKEREQKSIVEENIPSKFRRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LB57</accession>
    <name>A0A367LB57_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7492</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LB57"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="70" mass="7646" checksum="B6052B2943C1D634" modified="2018-11-07" version="1">MGYVRVLQVGTLKYLEKIISISFSHLLNTNTSPASNSSSIASFRLSRDSSSSSLLRNHLPDSSTLHPLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LB88</accession>
    <name>A0A367LB88_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_7350</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LB88"/>
    <dbReference type="STRING" id="1330021.A0A367LB88"/>
    <dbReference type="OrthoDB" id="433512at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="498"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="526"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="613"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="613"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI11674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="662" mass="74662" checksum="BDC15164C0B1592E" modified="2018-11-07" version="1">MATDASSPAQRRRSHHHHTPVIPGEVPVPNGPLPTDSESDDSGPRDERHIFSHVTRPDDCYTPDGVYWADLPWADRVAFVSAVDRREAAQELRSLGSMIKKDPLSPLSWYFRHAVIPGAGLGLEGYVLFSIGNLEPLFKQVWPQCWEKHQVCSQNWVASVTYLEIIGIMVGQAAVGVIGDWIGRRWGLIQDAVIMLIGLLMLTASWGLTLEGWVICYAWSLFFYSLGVGGEYPITATSSLEGADTAGKLSTRQDRLHRGRRVTTAFLMQGWGQFVNQVLLMVLLVIFNKGSGSPPYSSSAAQFAFRLSFAFPAVGTAWLAYYRTWKMPHASRQLADAKSRSNVTGYDVNALRHCVHHFGGRLLATAGTWFCNDVFFYGNKLFQGQFIKVISDNPDSLMTTWSWNLVNITVSLAGYYLASLLIDNKLYGRKMMQQIGFLMCFLMFVIPAFQYDKYIKPEHIHAFQAMYFISSFFNQFGPNSVTFLVAGEVFPTPIRATAHGFSACLGKSGALLASVLYNYIDTRTKFWVVPWFGLAGMLLTWLFLPDTTGLDLKEQERRWNYIRQGKADEYHGVAVNPAHLSLWERIRGIGRTYDPELDWRAKIQDMRAEWEMVQKARGPRDSEDQDAHGMPEDGEFSQEIHDYFKGSAAWPRTMSSEKALSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBL6</accession>
    <name>A0A367LBL6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA mismatch repair proteins mutS family domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_7551</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the post-replicative DNA mismatch repair system (MMR).</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer of msh2 and msh6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBL6"/>
    <dbReference type="STRING" id="1330021.A0A367LBL6"/>
    <dbReference type="OrthoDB" id="295033at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03285">
        <property type="entry name" value="ABC_MSH2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.110:FF:000002">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.10:FF:000003">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000523">
        <property type="entry name" value="DNA mismatch repair protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000015">
        <property type="entry name" value="DNA mismatch repair protein Msh2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1420.10:FF:000017">
        <property type="entry name" value="DNA mismatch repair protein Msh2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011184">
        <property type="entry name" value="DNA_mismatch_repair_Msh2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032642">
        <property type="entry name" value="Msh2_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF35">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005813">
        <property type="entry name" value="MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="12">
        <location>
            <begin position="768"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="890"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="202"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="893"/>
            <end position="906"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00064337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI11823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="972" mass="107452" checksum="A862AF9ADF7AAA6A" modified="2018-11-07" version="1">MASRPELKLDDEGGFIRFFKSLPAVDHDTIRIFDRGDWYTAHGQDAIFIAKTVYKTTSVIRHLGRNDHTGLDSVTMTVTVFRQFLREALFKLGKRIQIWESPSGRMNWKCVKQASPGNLQEVEDDLGGQIDSAPIIMAVKVSARASEARSVGVCFADATVRELGVSEFLDNELYSNLESLLIQLGVRECLVQIDSKAAAAAANNNNNNNNNNNNNNNTKDGQDSELAKVRHVLDGCGVAIGQLPNADFATRDIEQDLARLLKDEKSASSLLLMPTTQSKSDLGLAMGSAAALVKYLGLLQDTSNLGQYRLYQHDLAQYMRLDAAALRALNLVPGPRDGASKTMSLYGVLNHCKTAAGSRLLAQWLKQPLMNKAEIERRQQLVEAFFADTELRQTMQEDHLRSVPDLYRLAKRLQRWGKASLEDVVRAYQVVIRLPGLIGTLEGVMDDAYRDPLDAAFTQPLRQLSDSLGRLQDMVEQTVDLDALDRHEYVIKPEYDEGLRAIRRRLDQLDVEIRREFAEAARDLGQEPDKKMFLETGHRVHGVCMRLTRQEAGCIRNRSGYQECSTQKNGVYFTTKAMQAQRREHDQLSHNYGRAQSSLVAEVVRVAASYCPVLERLAGVLARLDVVVSLGHCAATAPEAYVRPRIHDRGGGGGAKTRLVAARHPCLELQDDVNFITNDIELDRNKAAFLIITGPNMGGKSTYIRQTGVIALMAQVGSFVPCAEAELTIFDSILARVGASDSQLKGVSTFMAEMLETANILKSATADSLIIIDELGRGTSTYDGFGLAWAISEHIISHIRGFALFATHFHELTALANRFPQVRNLHVTAHVGGGGGGGDDDAQGRRRDVTLLYRVEPGVCDESFGIHVAQLVRFPEKVIRMAKRKAEELEDFSSTTTTTTTTTNTSPPALSYGREDVERGSLLLKRLLAQWKDQVRASADLSVDDKVARLRELVAADAELTANPFFQSIKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LC70</accession>
    <name>A0A367LC70_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear movement protein nudC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_0673</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for nuclear movement. May interact between microtubules and nuclei and/or may be involved in the generation of force used to move nuclei during interphase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LC70"/>
    <dbReference type="STRING" id="1330021.A0A367LC70"/>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06467">
        <property type="entry name" value="p23_NUDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000001">
        <property type="entry name" value="Nuclear migration protein nudC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037898">
        <property type="entry name" value="NudC_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356:SF3">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356">
        <property type="entry name" value="NUCLEAR MOVEMENT PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="6">
        <location>
            <begin position="25"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00059400"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00068398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI12020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="191" mass="21393" checksum="BE42E0F21DA9517F" modified="2018-11-07" version="1">MAELNNKDPTAEEEKAARQREAEQQAALPYKWNQTIAEVDVSFSVPGELKSRDLVVEIKKQSLAAGVKGQECIIKGEFPHAIHVDDSTWTLSANADGSKTVEIHLDKVNKMEWWAHVVTGAPSIDVTKIQPESSKLSDLDGETRGMVEKMMYDQRQKEAGLPTSDDQKKMDILNKFQQQHPEMDFSKAKIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LD43</accession>
    <name>A0A367LD43_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_0963</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LD43"/>
    <dbReference type="STRING" id="1330021.A0A367LD43"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050152">
        <property type="term" value="F:omega-amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006528">
        <property type="term" value="P:asparagine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07572">
        <property type="entry name" value="nit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000002">
        <property type="entry name" value="Nitrilase family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045254">
        <property type="entry name" value="Nit1/2_C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001110">
        <property type="entry name" value="UPF0012_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088">
        <property type="entry name" value="NITRILASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088:SF30">
        <property type="entry name" value="OMEGA-AMIDASE NIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01227">
        <property type="entry name" value="UPF0012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="3">
        <location>
            <begin position="13"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI12152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="307" mass="33724" checksum="10A8134A6AB74C82" modified="2018-11-07" version="1">MSSSTASVLQQNVKLACIQQKVQSDKDSNLTRASQLVSQAASAGAKIVVLPECFNSPYGCANFPNFAETLLPSPPSTQQSPSFHALSDMASRNRVYLVGGSIPERDAQVDGRYYNTCLTFGPDGRLLDSFRKIHLFDIDIPGKITFRESDVLSPGNKISLVRLDGYGTLAIAICYDIRFPELATIAARRGGAFALVYPGSFNLTTGPLHWELLARSRAVDNQIYVAMCSPARDMTAGYHSWGHSMIVDPMARILAEADEGEEVIYSDLSDELIVETRRSIPLASQRRFDVYPDVSKGEMIRFEEPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDS8</accession>
    <name>A0A367LDS8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">diphosphomevalonate decarboxylase</fullName>
            <ecNumber evidence="3">4.1.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L249_1219</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(R)-5-diphosphomevalonate + ATP = isopentenyl diphosphate + ADP + phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:23732"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57557"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.33"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:23733"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the diphosphomevalonate decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.33" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDS8"/>
    <dbReference type="STRING" id="1330021.A0A367LDS8"/>
    <dbReference type="OrthoDB" id="364779at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004163">
        <property type="term" value="F:diphosphomevalonate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000018">
        <property type="entry name" value="Diphosphomevalonate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029765">
        <property type="entry name" value="Mev_diP_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053859">
        <property type="entry name" value="MVD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041431">
        <property type="entry name" value="Mvd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054549">
        <property type="entry name" value="UVB_sens_RUS_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01240">
        <property type="entry name" value="mevDPdecarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977:SF3">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18376">
        <property type="entry name" value="MDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22700">
        <property type="entry name" value="MVD-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04884">
        <property type="entry name" value="UVB_sens_prot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="10" id="KW-1207">Sterol metabolism</keyword>
    <feature type="domain" description="Diphosphomevalonate decarboxylase-like N-terminal" evidence="16">
        <location>
            <begin position="15"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Mvd1 C-terminal" evidence="15">
        <location>
            <begin position="203"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Protein root UVB sensitive/RUS" evidence="14">
        <location>
            <begin position="490"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF18376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF22700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCI12579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="886" mass="95528" checksum="948C79A0E88593F0" modified="2018-11-07" version="1">MASATAIIYRASTTAPVNIAVVKLRRYWGKRDTELNLPTNSSLSVTLSQADLRTLTTASCSDSFRHGDSLTLNGEPADVSGARTQACFRELRARRARLEAADPSLPRMSTMALRIVSENNFPTAAGLASSAAGFAALVRAVADLYRLPDSPERLSVVARQGSGSACRSLMGGYVAWRAGERHDGLDSVADVVAPASHWPEMRALILVVSAAKKDVSSTSGMQRTVESSGLFSQRVSSVVPANMMAMEQAIKARDFAAFAKVTMAESNSFHACCLDTYPPIFYLNDVSRAAIGAVEAINAAAETTVAAYTFDAGPNCVVYYLQGDASTVLGAFSPVLDGVAGWKKDCHPTASSARLDEGIAQALKAGVSRVIMTAVGEGPVPSEEHLVAVSPNHQNKNTMPRRFEPSDMNGDDFAHRINAGRDITVVELSKSGHDPRLWTRSDRKGVSSSYLRSSLPPLFLTRPVISPRALGQVTKTQKQVRLRPQDGTTMRSLRKAIFAAFLPVDFPNSVSSDYLAYQTYDSLQAFFSTITSLLANRALLQGLGVGDANSSATFAMLLTISRNAVSNIVTIGFAHRFGLSIEPEAKKYRFLADLFNDSAFFLELYSPHLAPSAKALALCSAEGLRAVCGVAAGASKAALSLHFAQNDNLSELSAKEASQETAVSLIGLFVGSIVVRAVQDQTLVVCLVVVLSLAHLWTNYRGVRSVCMTSINKQRATILYNAYSMFSDVLSPEQVAESESIVFWDDIIRNADREPAMRIEFATNFGHAIRWGVSDVLVVDGPMHSRFIRPYAPGRPGNIKIMLWDGARPEHAILAWFMAMDTARATGAADPYGDAKETIDAKWRPRARDDSLWDGLEAQGWDLDTGAMETGPGVRIGVEVSASKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDW1</accession>
    <name>A0A367LDW1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aminoacyl-transfer RNA synthetases class-II family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_0648</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDW1"/>
    <dbReference type="STRING" id="1330021.A0A367LDW1"/>
    <dbReference type="OrthoDB" id="439710at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.30">
        <property type="entry name" value="GAD-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004115">
        <property type="entry name" value="GAD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF5">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="8">
        <location>
            <begin position="199"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="110"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI12615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="713" mass="80520" checksum="4F5858EC0377B691" modified="2018-11-07" version="1">MPSSPKELKDLTPGQAYARRAEILRLWHLYQRPDQPLVHAAAAGDFKSKPIETFVGFLGKRKDIGKHLSFANLTTPAGEVLQLCANAEHSSVAHSRFRNIPAFSPVRVRAVEEDEEKEDEEQQQEQEPKETFNSSDKQPCQSRAANKGDQTKRRRSLLLNDIRPLNSVPENWFVPTDSRFPPSDRHLQIRFHPELQARLKFRSWLKGEFTKYMMDERFVEVETPTLFKSTPEGAREFLVPTRHRGMAYALSQSPQQYKQVLMASGIPRYMQWARCYRDEDARSDRQPEFTQASMPRPSPCSLDLEWAFTSAAEVMNQVTDMIVHVLKAFCPAQSYEVINGAKIPVVPDLRRKASFASPTHCFTNITFADSIAAFGTDQPDLRIPNRIHAFRDLDSIRQFVGVISRLSDPLVEAFTLRPQSRSIKDIRRFVRKFMDDLPQAFDKNPDGKPQILIWDESQPLRGFSSLGHGYQRILESTLGQADFRGGDIFVFQARKKPMTGHVPSSTMLGKFRKLLWNSLVEEGFLNKQRLGQPGSLQFTWVTEFPMFKPVERGEPGQGVAGLACSHHPFTAPLSEGDLELLFTKPLEAKSATYDLVLNGIEIGGGSQRNHIAVVQEFIMRDILRMPEEKVQGFSHLLNALRSGCPPHAGFALGFDRFVALLCDTGTVRDVIAFPKTMKGEDPFVESPGKLSDEQLAPYGLQLAATERHGEPDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEF0</accession>
    <name>A0A367LEF0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_0891</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEF0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI12803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="96" mass="10777" checksum="4A26A4EBB919A107" modified="2018-11-07" version="1" fragment="single">PRERSTIAIKLKVPRVTYILAKLAYPQGTRAATYNWREVPSYADSKEDREALQIRGCFASSEGIADLAVAYKDYINPCVSPRLAKDMPNPFIDNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LF61</accession>
    <name>A0A367LF61_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_0653</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LF61"/>
    <dbReference type="STRING" id="1330021.A0A367LF61"/>
    <dbReference type="OrthoDB" id="44467at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071913">
        <property type="term" value="F:citrate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000064">
        <property type="entry name" value="Mitochondrial tricarboxylate transporter (Ctp)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF4">
        <property type="entry name" value="TRICARBOXYLATE TRANSPORT PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="20"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="115"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="212"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI13065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="33467" checksum="367311424A6D10B3" modified="2018-11-07" version="1">MASSPQDKGEALPEKPTRAPSALRSVIAGATAGAVEIAITYPAECTCRPVAKTRSQLNRRLEAGQKLPWPPFGKQWYAGCTTLIVGNSAKAGIRFVAFDQYKQLLADADGKLSGPRTVLAGFGAGVTESLLAVTPTESIKTTLIDDRKSAKPRLRGFLHAVPIMARERGIRGFFQGFVPTTLRQAANSATRFGSYTLFKQMAESYTAPGEKLGAVGTFAVGSLAGFVTVFVTQPLDTIKTRMQSIDARRLYGNTLRCAAVIFRDEGVLTFWSGALPRLARLVLSGGIVFTMYEKSMDLMNRVDPEMKYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LF93</accession>
    <name>A0A367LF93_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_0999</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LF93"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI13095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="80" mass="9468" checksum="414E9AEF32C22109" modified="2018-11-07" version="1">MVESFPYYLLCINTPVLTQLRMILQPRLCWVRWALHSFDGSQVFTTKDHAMEMKPYLLERPPRFRPMSPDAPVSYFGAFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFE1</accession>
    <name>A0A367LFE1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFE1"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="131" mass="15015" checksum="69C969FF9F659441" modified="2018-11-07" version="1" fragment="single">MTVMVGAAERASSHYVCHGSFGLAGWIIEINRGGNICRGGTSRLVWGLDEEKEKEDAGHGRRDKERREPVERGVRDIESVMERIGEERRGEERARRRERAEGGKNNKGRELRWPETESTEIYIRSHAMHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFR2</accession>
    <name>A0A367LFR2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Swiss Army Knife protein DSP-PTPase phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_1190</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFR2"/>
    <dbReference type="STRING" id="1330021.A0A367LFR2"/>
    <dbReference type="OrthoDB" id="432447at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057023">
        <property type="entry name" value="PTP-SAK"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22784">
        <property type="entry name" value="PTP-SAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Swiss Army Knife protein DSP-PTPase phosphatase" evidence="3">
        <location>
            <begin position="111"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="236"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="244"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="281"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI13263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="352" mass="39785" checksum="F9885AECC076AC0A" modified="2018-11-07" version="1">MKLSFRRRPCSRLTSKHFDTMRLSTLIVLFFNAAAITQASVLTWTTTDSRSVHLSSRRSPYVDSGNSRTYENDGPGFWRFEWVKDFLHPGDRLARSSAPHYNCQDCDQRLTAASIQFLKDNKITHVISLNEEASSQSIRNALVRNKIAYTALPTSDFQAPTLEDLAKAYGAFKQHRDGTLVWCGYGHGRTGTMVSALQILSNHDMPSGKKMSHWEYKENHVETVDQIELLDNLQKSLRKASSPQHQQQQQQQQQQQQQQAETAAAHPLDRSKSSGGSSVVRPEEGSIKAEDRTAREATDIKAGHEFAQEAQQARRQLVREDGRRQEARAAKHEEQGVRCPGSTRGEAEHERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFU4</accession>
    <name>A0A367LFU4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_0655</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFU4"/>
    <dbReference type="STRING" id="1330021.A0A367LFU4"/>
    <dbReference type="OrthoDB" id="2107880at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004019">
        <property type="term" value="F:adenylosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046040">
        <property type="term" value="P:IMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.440.10">
        <property type="entry name" value="Adenylosuccinate Synthetase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042109">
        <property type="entry name" value="Adenylosuccinate_synth_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001114">
        <property type="entry name" value="Adenylosuccinate_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846">
        <property type="entry name" value="ADENYLOSUCCINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11846:SF0">
        <property type="entry name" value="ADENYLOSUCCINATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00709">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20180">
        <property type="entry name" value="UQCC2_CBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00788">
        <property type="entry name" value="Adenylsucc_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI13288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="194" mass="21936" checksum="AEB05A141E54753B" modified="2018-11-07" version="1">MERWKLTDILTPGVQPCALHLANGVSYSFHLLSSGLVNPKCPNLSSVVAHIPTFFKVLVVGEGANALLLDLDRGSYLYVISSSTGISGIVNGLSFDIRKIDEVMSVVRSYTTRRRIYADALAQWPTQALRPDYQFQDVLRKAVDERFQSYRPSMEAEEVQRARALQILIQNKFRDKARELFSIGFLRRGEERNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LG85</accession>
    <name>A0A367LG85_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5616</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LG85"/>
    <dbReference type="STRING" id="1330021.A0A367LG85"/>
    <dbReference type="OrthoDB" id="2019266at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="1">
        <location>
            <begin position="152"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="311" mass="34067" checksum="D097AD36A3CEB487" modified="2018-11-07" version="1">MEELPFSSQVIISSFSASKLYKNLIHTCTISQPREPRSLSIMETQLCSQSDRPIVNQEKRDKVVDGLPAAFRLALPEATQNYEQDSEWCVIDDGTGWQELRLHDYDKVFRVPGLYEKLIQEVLQCQSPAVVSDLLVKQLVGEGVDLSCVRVLDVGAGNGLVAEELRKRGIGKVVGVDIIAEAAQAAERDRPGIYEDYRVVDLRALGADAAADMAGEGFDALIAVAALGFGDMQPEAFKVAFNMVRQDGLVALTIRDDFLSESDTSGFAALIGSIVSSGGLDELRELTYQHRLTTTGQPVYYHAIVARKRCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGR2</accession>
    <name>A0A367LGR2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGR2"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="72" mass="8472" checksum="2CA206F2662D87D4" modified="2018-11-07" version="1" fragment="single">RARYSGYSGSDRSDRSDRLDRLDRSDRYKSSSKSPIFLLSNSGYLYTFNLFFTAFLFTFRPTNYLIRTGYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LH51</accession>
    <name>A0A367LH51_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADH dehydrogenase [ubiquinone] iron-sulfur protein 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Complex I-15 kDa</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">NADH-ubiquinone oxidoreductase 15 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L249_8115</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I NDUFS5 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LH51"/>
    <dbReference type="STRING" id="1330021.A0A367LH51"/>
    <dbReference type="OrthoDB" id="9992197at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24141">
        <property type="entry name" value="NDUFS5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019342">
        <property type="entry name" value="NADH_UbQ_OxRdtase_FeS-su5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15224">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15224:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="14"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR619342-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCI13740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="100" mass="10890" checksum="AA116188FF2ECBD0" modified="2018-11-07" version="1">MASGYGMHGGPGRCFPFWQDVLACYVVNTSTDNDSGKKKCALPLEDYYECLHHKKEHVKALALQAALKGVKPTAPVYNEPDAKHIKSLGLVGNNTLSENT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHB3</accession>
    <name>A0A367LHB3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_8285</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHB3"/>
    <dbReference type="STRING" id="1330021.A0A367LHB3"/>
    <dbReference type="OrthoDB" id="6365676at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="391"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="419"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="46"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="330"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="345"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="372"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI13789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="497" mass="54634" checksum="743085B7E96A90B1" modified="2018-11-07" version="1" fragment="single">RIVSRAVVLRREMGDSAVAGTVVGIVIFLLALCLYPIIVGQVKRRRRERLDAESGRPSSIDSHRNHVELHPAATKEWNWSRRSQQASSSSSSSSSPSPSSPTLNHEGVCLAQPSDGRNHHAGQGMSADYYNASIPSEQSLGVTAPSSYPHVHAVPSVSGTFKDRIKRLLRQGTGYADHGEGPQLASRSGPAVAIWKTSVVQPWPSQHLTHEMSRSPSSSPPAYPAPGTVNPMDIMPASTEVEVWHRKEQELLAYSHGGPPLGSPSPPDKDAEVVSLADHVDDSGTAETVSPPLDHVDGNLDHADDLANLPAALQRPPAVIFNQAAIPAQQRPLTGGDAPPRIYHSDQSTPFNPSLPNTAVLPDSPRDGWLTSSDSRSSNSPQSPNTLTRAYCCDEPGCTQTFNQLHKLRHHQRYHSKAYKCTYNACERAFGTKTHLERHINERHEQRRRFHCPIPHCIYHKATGRGFSRRDNWRRHMMSKHGTAQDYSPIIVDTIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHD8</accession>
    <name>A0A367LHD8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Negative regulator of the PHO system</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Serine/threonine-protein kinase PHO85</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L249_7901</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">When phosphate concentrations are high it phosphorylates the PHO4 transcription factor thus establishing repression.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with a number of cyclins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHD8"/>
    <dbReference type="STRING" id="1330021.A0A367LHD8"/>
    <dbReference type="OrthoDB" id="193467at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07836">
        <property type="entry name" value="STKc_Pho85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000062">
        <property type="entry name" value="PHO system negative regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000410">
        <property type="entry name" value="Probable PHO85-cyclin-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF46">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="10"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00066118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCI13854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="324" mass="37298" checksum="F7F015A9E8608AB7" modified="2018-11-07" version="1">MDGKRHPSSFQQLEKLGEGTYATVFKGRNRQTGELVALKEIHLDSEEGTPSTAIREISLMKELKHENIVALHDVIHTENKLMLVFEYMDGDLKRYMDTHGERSALKPATIQSFMYQLLKGIDFCHQNRVLHRDLKPQNLLINSKGLLKLGDFGLARAFGIPVNTFSNEVVTLWYRAPDVLLGSRTYNTSIDIWSAGCIMAEMYTGRPLFPGTTNEDQIIRIFRIMGTPTERTWPGITQYPEYKPTFQMYATQDLRNILHAIDPTGIDLLQRMLQLRPELRISAHEALQHPWFNDIVMHQQQQQNLHAQARAYQQGVPTQTFENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHE8</accession>
    <name>A0A367LHE8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_8262</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHE8"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017076151" evidence="2">
        <location>
            <begin position="25"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI13863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="404" mass="45701" checksum="58F8505184395270" modified="2018-11-07" version="1" fragment="single">GQRVDGLKLFFFLLFFFFFRLCLCSSRLQTTAAAYPVPREKGNPRPAWRERERAATSPGYDHRIRICGDLEELGQLLQRYIRSRHTLEHHFKLLRYQLQPTSLIGLPLLQRPVEEGGVAADTRLGALEMHDSLPFSIFIEKKTMVAVHCRALSPSLSLPFVRWPAAYRNPGKADDDAPVNSHHPYIIRPNEYQSLSSGAGTTVQYNERRRNGLDARRISRPTRLSPRAGKASEEGRAAPPLPTIHFTRWTRKRRKRRSFSFQRKTGLQSQIHLLSVSLPLFSFFLACFPVSPPLFPLRHESRIGVLNTKHVRDSAIDFKVLKAACRPALQPARAASGTFPALLAERAERSSPPPPTPQPPGTQHSRDLEAGHGAKSKDCLHTWLPLLCLAGLWLFRPSSFFSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHP0</accession>
    <name>A0A367LHP0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHP0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="67" mass="8040" checksum="C0F09ECF16028673" modified="2018-11-07" version="1">MLRLEQQAIAQSSRPKRKPLPPRSPFDRDKILFLAKVAPFFEQGEEYRYNTEHFLNYLDSVFADPYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIX4</accession>
    <name>A0A367LIX4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIX4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="100" mass="11325" checksum="B58F406DCE995686" modified="2018-11-07" version="1" fragment="single">PLLSFSFGIAPSAAPLDRAPGNTIGVPIIRCGRSFRSVPLLLLKRIRPLFLLLLPVQSRNPSNRPYRRFCNPIRPGRNRPRPPYSLPPLPHYPRDYLSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJ89</accession>
    <name>A0A367LJ89_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Actin-related protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Actin-like protein 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_6108</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJ89"/>
    <dbReference type="STRING" id="1330021.A0A367LJ89"/>
    <dbReference type="OrthoDB" id="421448at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044396">
        <property type="term" value="P:actin cortical patch organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10221">
        <property type="entry name" value="ASKHA_NBD_Arp3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000029">
        <property type="entry name" value="Actin-related protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000006">
        <property type="entry name" value="Actin-related protein 3 (ARP3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="41"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI14470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="440" mass="48050" checksum="723D7585372F15A1" modified="2018-11-07" version="1">MANQTPAVVMDNGTGFSKLGFAGNDSPSFVFPTAIAIKGPAGGSGGSGSGRPAVSNKPSFLTGGAGPSSSHLSSKRGTEDLDFYIGDAALAAAAGPGYGLHYPIRHGQIENWDYMERFWSNSIFKYLRVEPEDHYFLLTEPPLNPPENRENTAEIFFESFNCAGMYIAVQAVLALAASWTSSKVTDRSLTGTVIDSGDGVTHVIPVAEGYVIGSSIKSIPIAGRDITYFVQSLLRDRGEPDSSLKTAQEIKEEYCYVCPDIVKEFAKYDRDRERFARHVVTHPGGRQVTVDVGYERFLAPEIFFNPEIYSSDFLTPLPIVVDGVIQQSPIDVRRGLYKNIVLSGGSTLYKDFGRRLQRDIKQLVDARIRASEVRSGGARSGGLEVQVITHKRQRHGPWFGGSLLGQTPEFRSYCHTKAEYQEYGPSIVRRFALLGGPGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJM1</accession>
    <name>A0A367LJM1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HhH-GPD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_6838</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJM1"/>
    <dbReference type="STRING" id="1330021.A0A367LJM1"/>
    <dbReference type="OrthoDB" id="10265068at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045138">
        <property type="entry name" value="MeCP2/MBD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15074:SF0">
        <property type="entry name" value="METHYL-CPG-BINDING DOMAIN PROTEIN 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15074">
        <property type="entry name" value="METHYL-CPG-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI14599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="458" mass="52110" checksum="A937C52CCFEA5D51" modified="2018-11-07" version="1">MACSDVLLLFFFDVAEESRDFLRDVIKSSATPRHETERLQNQSLLAGAEDWNALVDCARAVRRSRPYDSLALEGQDDLSYVWPALFGLGGSVAAPTGDAWEETDRLIALCKKLEWDAGSLFCTGGSLDDYPEPQSKKRRRSGGTASSHYWVDASGTGARRDSGSCRFGADQKKWPLHQARVFSACPASNDQARDSATALWSSRSTSSPYFLGQRDTGSRKRPPPGTISCIRFPPLSSARFGIVQEEMANDPFWLLMAVTFLIKTSGRLAIPALRDVKKRFPTPQQLCDAANEQQLSDMIRHLGLVVVRVAMIQKYARTFVDQPPRPECRFRVRNYEKREVAPSLEKCVADADDEAWEIGHMTQGRYALDSWRIFCRDVLLGRAKDWNGKGREAEFQPEWMRVMPTDKELRAYLRWMWMREGWEWDPATGERRVLREEMRRAVDEGRVEYDETGGLRVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LK92</accession>
    <name>A0A367LK92_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_6470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LK92"/>
    <dbReference type="STRING" id="1330021.A0A367LK92"/>
    <dbReference type="OrthoDB" id="21266at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070692">
        <property type="term" value="C:CTDK-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032786">
        <property type="term" value="P:positive regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000032">
        <property type="entry name" value="CTD kinase subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042326">
        <property type="entry name" value="Ctk3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024637">
        <property type="entry name" value="Ctk3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024638">
        <property type="entry name" value="Ctk3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28291">
        <property type="entry name" value="CTD KINASE SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28291:SF1">
        <property type="entry name" value="CTD KINASE SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12243">
        <property type="entry name" value="CTK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12350">
        <property type="entry name" value="CTK3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="2">
        <location>
            <begin position="22"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI14797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="278" mass="31528" checksum="C19D12CCDBD6AD5B" modified="2018-11-07" version="1">MPFLNAVSNLFYGFNFKKDMADPFEVRMRFSSQLQHLNASVNSAQKAAQYALKFKEMDEDLHSCILEQVERNNMNTRANIMYFIEHFLDLAKEGHGDYVRMMSRDIIRVVDAVAPDDGSGAANVKVVRKVLQGLRDKGHLESQVVSQIDDVLREREINDDDLGLVSSPPTGGDVNMVDGPPSQTTQRPAPKRPAPPPLDKRQIEQRIEEDRERHKRARESIWATPKGEDAEMNKLWEETSDFGDDDDRLLAEETEDFAKEMAMQLCPHKRAAANGGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKH3</accession>
    <name>A0A367LKH3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DUF726 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_6746</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMCO4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKH3"/>
    <dbReference type="OrthoDB" id="277931at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007941">
        <property type="entry name" value="DUF726"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920:SF3">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05277">
        <property type="entry name" value="DUF726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="515"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="560"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="377"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="996"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="863"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="37"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI14900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1080" mass="117760" checksum="609D09F4B8F8D373" modified="2018-11-07" version="1">MDNNNNNNSSSSKDKEADADDFGLPVRRYPTPEPAGDDGKAYGEKRLTPEPEEVLSPTTPKTESDGDDADFQDAQPVIEDSQPIATLQATPKTNSRPATPGAEQPKPDDSPLPPADAATPEPSKSLDKTPRAEDATPRPVTSRPSAEVSSRTRRSRGDSLTANGLAISEFSHQQLSMRKEDKDEDEDVGWQTMPAYARFDMYDDDDRLIAREHVDDEEPDEAGYNGLGGAGNGYTRVIMDDDAQSATSMDENTKYLFNDTNGTSMAGDDEGRDALAQMQATKDLLTEGQRIAYVGVVRLEIAKLVHDSDGVDITKKTKREVQAAAEAVKMWGQKMMIRLYSHMDISAAEQLMIEQLAAHDVRPADLTPALHANSRVHNPMAATGGDRKSAPQSPNAAEEKAADAPPPYEADESSEVPEAQMPSQLPTTDKIDIDLRWTVLCDLFLVLIADSAYDARSRVLLERVGASLDISWIDICRFEKRVTDALEMQQQAEKENWNEDEHMETRRKLALKRRYVMMGLATVGGGLVIGLSAGLLAPVIGAGLAAGFTTIGVTGTSGFLAGAGGAAVITSGAAASGSIIGIRAANRRTGAVKTFEYRPLHNKKRVNLIVTVSGWLTGKVDDVRLPFSTVDPVMGDIYSVLWEPEMLRSMGDTINILATEALTQGLQQILGSTILVSLMAALQLPIVLTKLSYLIDNPWAVSLDRATAAGLILADSLIERSLGTRPITLVGYSLGARVIFSCLQELARKGAYGVVQNVYLFGSPVVVKKEEYIRARTVVCGRFLNGYNRNDWILGYLFRLTNGGIRRVAGLGPIEDCPWLENMDVTDLVAGHMEYRKSMPTLLMKCGWMVEKEEFSEIEDPDPENHQERQRELINEIEEARKELEREGKAKKGGKFGLFGRRKKAERQEWEVYEDSTGKGEKEGNSAGVLFDVDAIRAELAKEKLAGTSEETLQVREIVSTLPPMKLDISSATEGRKPLRETKSAEAIPVQRMMEAAEEGGGGGQVRGKGKAQGRKSFIIEPSRTSETTEAAGDEEEKGPVRSGVTPSQTMPNVALAASSWTDPDDEDFGVEKEISMTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LL96</accession>
    <name>A0A367LL96_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Polyadenylation factor subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_6425</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for 3'-end cleavage and polyadenylation of pre-mRNAs. Also involved in chromosome segregation where it has a role in chromosome attachment to the mitotic spindle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LL96"/>
    <dbReference type="STRING" id="1330021.A0A367LL96"/>
    <dbReference type="OrthoDB" id="16717at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001039">
        <property type="entry name" value="Polyadenylation factor subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:002008">
        <property type="entry name" value="Polyadenylation factor subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045245">
        <property type="entry name" value="Pfs2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836:SF0">
        <property type="entry name" value="PRE-MRNA 3' END PROCESSING PROTEIN WDR33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="130"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="171"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="213"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="368"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="421"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="427"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="440"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="459"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="471"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="485"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="506"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="525"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI15157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="619" mass="67571" checksum="7F080AEF73C134EB" modified="2018-11-07" version="1">MAYEPRGDHGDRGGHDGAYLKIRGRRPVTDYSATVTHWQRHRTANYKGGYDGEAERPSASYIVDMIPPAGRPTSASDSIPSKHLHSSLNKIKHPINLVRWTPEGRRLLTASTSGEFTLWNGTGFNFETIMQAHDSAIRALEYSHSDDWLISGDHDGLIKYWQPNFNNVQSISAHSDPIRDLAFSPNDSKFVSASDDSTLKVFDFALGQMESKLEGHGWDAKTVDWHPTKGLLVSGSKDHLVKLWDPRTSRCLTTLHGHKSTITKVMFEKVRGMCLATSARDQTARVFDLRMMRDICLLKGHEKDIATLSFHPIHPNLLTTGGMDGTLFHYLLDTPNPPPGQALTLAPYDSLDPATAPAQSVWPSHRLAFAHDYAIWSLDWHPLGHILATGSNDRITRFWTRARPGETDVFQDRYHIGEAAAEAQGTWDRRGNRRQRQEEEQQEMEDEMDALVDQDALRGAPTGLPGIPGLPLGGGMVPGLGSGVAPPPPPPPPPPIPGVGPHGSTGPPPPPPPPPPFALPGLGGAPPPPLPGLDPNKPPDPAQLMEIMKKAGVPLPPPGSLPPGLILPPGSFPMPMQLPQPDLDKADGGGSGGRRRVPLPSQEESLRQEQRQGKYTRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLR7</accession>
    <name>A0A367LLR7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome c oxidase assembly factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_6732</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Required for assembly of cytochrome c oxidase (complex IV).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 9">Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the COA3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLR7"/>
    <dbReference type="STRING" id="1330021.A0A367LLR7"/>
    <dbReference type="OrthoDB" id="10018333at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041752">
        <property type="entry name" value="Coa3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018628">
        <property type="entry name" value="Coa3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15642:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15642">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09813">
        <property type="entry name" value="Coa3_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome c oxidase assembly factor 3 mitochondrial coiled-coil" evidence="10">
        <location>
            <begin position="19"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF09813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI15340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="73" mass="8332" checksum="5CD331138458308C" modified="2018-11-07" version="1">MYDAHSTYYDRRLRQGPALIRARRPYLFRNSLTGLGLVLFITGIYAYTLKAVGQDEFADVKVPDAPQPPTEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLW0</accession>
    <name>A0A367LLW0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLW0"/>
    <dbReference type="STRING" id="1330021.A0A367LLW0"/>
    <dbReference type="OrthoDB" id="548474at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038966">
        <property type="entry name" value="TMA17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40422">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40422:SF1">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="173" mass="18863" checksum="05D00B5D336618A9" modified="2018-11-07" version="1">MSADTTPIPPSRFAAAIMDLSPGMLRLKLLEIRNSVAHLQYSNDQLKPFAETETPDQDCVEALCENDVVINRMAQRVALIRAEVERRGLSWSDFNVDDPPPSVHDEHTTAGDNSHGPHPAWSDGTFQAGSLTNGHVRLHDASEATSSHTAEHPTGQDPPAVDERDEPDGGMHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLY8</accession>
    <name>A0A367LLY8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_3555</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLY8"/>
    <dbReference type="STRING" id="1330021.A0A367LLY8"/>
    <dbReference type="OrthoDB" id="67317at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056552">
        <property type="entry name" value="Ribonucl_Kappa"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23489">
        <property type="entry name" value="V-ATPase_su_f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI15438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="88" mass="9574" checksum="98BE7FFA8BD0B715" modified="2018-11-07" version="1">MKPLVSAMNAWTCTVISVFAIVILSILAGLYRAGHEEFVGGREDPEDGKAVSGTIFTAVFVYMGFFVFCGFQGLLHVRENRRGSIALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LM27</accession>
    <name>A0A367LM27_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_3593</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LM27"/>
    <dbReference type="STRING" id="1330021.A0A367LM27"/>
    <dbReference type="OrthoDB" id="407146at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.20">
        <property type="entry name" value="Peptidase C15, pyroglutamyl peptidase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016125">
        <property type="entry name" value="Peptidase_C15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036440">
        <property type="entry name" value="Peptidase_C15-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402">
        <property type="entry name" value="PROTEASE FAMILY C15 PYROGLUTAMYL-PEPTIDASE I-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23402:SF1">
        <property type="entry name" value="PYROGLUTAMYL-PEPTIDASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53182">
        <property type="entry name" value="Pyrrolidone carboxyl peptidase (pyroglutamate aminopeptidase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="116"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="128"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI15484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="303" mass="34299" checksum="5D7B78E79498FC75" modified="2018-11-07" version="1">MGSQEKELTVLPFGDHQAVNPSWEIAKRLPAELPPTQGGGPRVRIIVYPEPIRVSYRTVRNLVPTLWDDDDKKKEEEEEEGDDGGKNRRRRHIDAAIHIGMAGPRAIYQLERRAHRSGYPTPDVDGALPEDDDDNDNDVEQQEEDDDDDDDDDDKRRPAELTTDLRLEDILARWRNLTDPDMDLRLSDDAGRFLCEFIYYASLSELAARNRRRHVVFFHVPCHATERYIAQGHELALSLVRALADSLVAAGRGPETVVTTWWGCGKHIVAVMKDIPVDQRCSCNPKVERDGTLYPPMGSKPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LML0</accession>
    <name>A0A367LML0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DNA polymerase</fullName>
            <ecNumber evidence="16">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">L249_3505</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the DNA polymerase type-X family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="16"/>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LML0"/>
    <dbReference type="STRING" id="1330021.A0A367LML0"/>
    <dbReference type="OrthoDB" id="205514at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00141">
        <property type="entry name" value="NT_POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000010">
        <property type="entry name" value="DNA polymerase lambda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.110:FF:000005">
        <property type="entry name" value="DNA polymerase POL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.210.10">
        <property type="entry name" value="DNA polymerase, thumb domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002054">
        <property type="entry name" value="DNA-dir_DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028207">
        <property type="entry name" value="DNA_pol_B_palm_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018944">
        <property type="entry name" value="DNA_pol_lambd_fingers_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037160">
        <property type="entry name" value="DNA_Pol_thumb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022312">
        <property type="entry name" value="DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002008">
        <property type="entry name" value="DNA_pol_X_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029398">
        <property type="entry name" value="PolB_thumb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276:SF28">
        <property type="entry name" value="DNA POLYMERASE LAMBDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276">
        <property type="entry name" value="DNA POLYMERASE TYPE-X FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14792">
        <property type="entry name" value="DNA_pol_B_palm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14791">
        <property type="entry name" value="DNA_pol_B_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10391">
        <property type="entry name" value="DNA_pol_lambd_f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00869">
        <property type="entry name" value="DNAPOLX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00870">
        <property type="entry name" value="DNAPOLXBETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00483">
        <property type="entry name" value="POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81585">
        <property type="entry name" value="PsbU/PolX domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="10 16" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 16" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BRCT" evidence="18">
        <location>
            <begin position="114"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="72"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="215"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="289"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="555"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="253"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="303"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="555"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; Schiff-base intermediate with DNA; for 5'-dRP lyase activity" evidence="15">
        <location>
            <position position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR622312-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU366014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RCI15676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="691" mass="78107" checksum="EF70FA10AF168221" modified="2018-11-07" version="1">MKPQSEKAAFFELWKSLDADDEELDSREQLDRRRRAAFFAPKERESTGEEETDETVIPDSVIPAVKRMRRSDSTPLLLPAKRPSSNQSPSLEVGMRKRRRGGASAAVAPKMRRTEDQVFRGLVFFYVPNNDIAPARRLRITRAREHGACWARDPSTATHIVVDKQLDYRDVGKVVSEEALARLPRLVNEEYPIDCIQFRSLLDDTQKKYRVPGAPVAEDERGQHELEVPASPVPDAGREAELPPQNTSVVDATPQPTTTTTTRPLEEGAEDELARCVSMMQQYQHLPLDHHEEDEEGSDSDSSSDKPKPKPERKGGRFEDGFACNQAGQKDATAENPNGRTVQVLQSMADYYERIDDHWRSSGYRKAIGTLKRHDTMVRTAEEAADLPHIGWRIAQKIEEIVSTDRLRRLEYARDEPTDEALQLFLQIYGVGSRLARQWVAQGYRTLEDVARRARLTPSQRIGLEHYDDLQKRIPRHEVEALSSAVRATAEGIDPAVEFITGGSYRRGADSSGDVDLIVTKRGTNKAFELRPFLDELVDRLEEKGVVVARLSSSFSSSSSSSSSSSSSSSPTTMTSRRKKESGGSIWHGCCKLTMDKDKGKKEDATWRRLDLLLVPETEMGGALLYFTGDDLFNRSMRLLAARKGMRLNQHGLFRGRRRGVGEGDLVEGRDERRIFEILGVRWREPWERWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMW2</accession>
    <name>A0A367LMW2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase III subunit RPC3</fullName>
            <shortName evidence="8">RNA polymerase III subunit C3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_2221</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMW2"/>
    <dbReference type="STRING" id="1330021.A0A367LMW2"/>
    <dbReference type="OrthoDB" id="272392at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055207">
        <property type="entry name" value="POLR3C_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013197">
        <property type="entry name" value="RNA_pol_III_RPC82-rel_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008806">
        <property type="entry name" value="RNA_pol_III_Rpc82_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039748">
        <property type="entry name" value="RPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12949:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12949">
        <property type="entry name" value="RNA POLYMERASE III DNA DIRECTED -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08221">
        <property type="entry name" value="HTH_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05645">
        <property type="entry name" value="RNA_pol_Rpc82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22536">
        <property type="entry name" value="WHD_POLR3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase III subunit RPC82-related helix-turn-helix" evidence="11">
        <location>
            <begin position="9"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase III Rpc82 C -terminal" evidence="10">
        <location>
            <begin position="159"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase III subunit RPC3 winged-helix" evidence="12">
        <location>
            <begin position="482"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="359"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="383"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI15727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="643" mass="73135" checksum="72C3F99D1B5B0DE2" modified="2018-11-07" version="1">MLVTKHAAELCALLVNDLFGELPSRILAALFSKGRSTITQLAQNTSLSPRHLRNGLGALIQQNLLYHHTDAASDVTSYEANSDACYNLVRFGKILEVVECQFGTAERDLLQTLMLLGCARVADLGHAFGSRGPTTNGHTNGTQGSAPGLISSENHLHQVLCRLIQHEIVETIQPSSFRNPAEVYREIENEITKTVPGDKVSKNKIDQHMQVVERFKEFRDQRRALKRQLDQTYGSAAKRRKIQNGTAHTDFTYRDDALSLNPNVVVRVNHQKCLVQLRNQRLADFAADTFGEVTGQVYRTLLELLTTQVTVCRPDPWIGDQVSSQQPTATSIEICENIDESVSLQSGIGKAPKDKIDLRSAEKVRSTPLAYDSDSDASDDEPEIRQRELQNADRDEFDDSDDDDVSGRHNAQQASRRNGERQSMVKFEDESKESRLDQMRQHLLLLAESKYRFVRCCGTAGRGQWTVDFGQLMERLRESELDAYIEQSFGRHGLRLTRILRDKGKLDEKMLPSTALMKKSDVQGKMLAMQMAGLVEVQEVPKDNSRLANRTLFFWFFDGERTQSQLLDDVYKAMLRILQTLQVERHKERDILSFVERKDVKGKEEEVMMAEHYLKYHQHLEQQQKLLGQVARLDDMVAVLRDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNB4</accession>
    <name>A0A367LNB4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNB4"/>
    <dbReference type="STRING" id="1330021.A0A367LNB4"/>
    <dbReference type="OrthoDB" id="5231339at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="216" mass="22295" checksum="0075A3863BB5BBAC" modified="2018-11-07" version="1">MGNGEKKWDATAERDLCISIIMSISNEGKASYNWPRVTTSMEALGHGFTKDAMSQHFSKVICKDFKNRRGEMPPESTTPSATATPRKRKPAALKLIDENGEGGGDVDDDANVTPSKAAAATPRKRKSAKLAADDGAADVGEAGVTPKKAAATPRKRRAAKKAPVSDDKVDASPPAAEEEADKTLAAAAAAAAAATTIKADVDGTETSADGGEAIAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNS7</accession>
    <name>A0A367LNS7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_3069</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNS7"/>
    <dbReference type="STRING" id="1330021.A0A367LNS7"/>
    <dbReference type="OrthoDB" id="410044at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070063">
        <property type="term" value="F:RNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.440">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002713">
        <property type="entry name" value="FF_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036517">
        <property type="entry name" value="FF_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045148">
        <property type="entry name" value="TCRG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15377">
        <property type="entry name" value="TRANSCRIPTION ELONGATION REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15377:SF3">
        <property type="entry name" value="WW DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01846">
        <property type="entry name" value="FF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00441">
        <property type="entry name" value="FF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81698">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WW" evidence="3">
        <location>
            <begin position="17"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="469"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="536"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="173"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="554"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI16070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="563" mass="64155" checksum="62A9DDA1CF759179" modified="2018-11-07" version="1">MLKSTYKPSAAFLAANAPLPPGWSEHKAPTGHSYYYNAKTKESTYRRPGLPVAEASSSTPPPALPPYAHIPNLADPQVANAYRAQFAPSPPSRHDARSGFQGRPRPQPVDKPVRKEAIPGCEPWVLVYTKYSRRFVHHPLKNTSFWRIPEKLMAGVLELDKARVRAKASGDGQGEKMEDKLPEKPKESVETEADGGEAEGQVSEYEEVEVSDDDDDDDDDDDEHRSKRQRTGESASDDQAEAVEFTEADIAAQLQLMGEEYGLEPGIEGDDGAANCDFTEHDAKCLFKDLLDDFNINPYSPWDKLVEEDRLVDDPRYTALTTMRARKECWDEWSRERIASLLEQRAKQEVKDPKIAYLAFLQDKATPKLYWPEFKRKYKKEAPMKDVKLSDKEREKAYRDYIARLKLPHATLKSDLMALLKAQPNHLLHNKSLSDGLPTPILTDIRYISLAPKERDALIEAYVQSLPPRGDDAEAVERDDRKKEREARERRERALEERNRVVEEERKQRAVEVAASKARLRRGEMEMEMAMRVDKRGLQSQLARLQAEDGPSLEEAKREEPLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPD9</accession>
    <name>A0A367LPD9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Catalase core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_2828</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 8">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Alkaloid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the catalase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPD9"/>
    <dbReference type="STRING" id="1330021.A0A367LPD9"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009820">
        <property type="term" value="P:alkaloid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08157">
        <property type="entry name" value="catalase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000001">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465:SF26">
        <property type="entry name" value="CATALASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0017">Alkaloid metabolism</keyword>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="4" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="10">
        <location>
            <begin position="10"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI16303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="490" mass="55008" checksum="DD900717A3DBC5B7" modified="2018-11-07" version="1">MSDSKNPMCTLANGQPSPNPGSSQQVRYGNSNGGLVVLSDVQTVEVLAHFARERIPERSVHAKAAGAWGEFELLKDVSDLTDAKWLTGVGKKTKLLTRISTVGGEKGSADTVRDVRGWATKFYTEEGIQDFVFNDLPVFFIRDPIKFPSMNRSHKRHPQTNVPDNAMFWDFHLNNPEGIHALMHLFGQRGIPASLRHINGFSVHTYTLNKADGSYVYVKWHFKPDSGIETMDADRAVYLAGSEPDYHVKDLFNAIEKGDFPSWSVYVQVMKPDEVAKSPVDIFDDTVTWPHDKYPLRLVGRMTLNKNPGNYFQDIEQACFSPSNMVPGIGPSADPVLQARMFSYPDAHRYRVGPNYFQLPPNRPINKVYAPYVRDGPGTMNGNYGADPDYVQSELRPVAQSKRVAMPTHELYSGHVGSFETSLTDKDFVQPRELWKIICGEPKGQEQFLHNIMPTLQGIPDKMKKQVVEYFGRVDGALGQLIEKNLAKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPF9</accession>
    <name>A0A367LPF9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_3204</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPF9"/>
    <dbReference type="STRING" id="1330021.A0A367LPF9"/>
    <dbReference type="OrthoDB" id="2851338at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF31">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN YCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="258"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="213"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI16323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="496" mass="54463" checksum="D6396EF12B98D545" modified="2018-11-07" version="1">MSGLLHVTTQPSSPNVPQSHFTDWYNNEHGPNRLRLAHHFPHGHRYKASDNLTPPYLAIYDVKDAKGLFSDPTYTSLRTNRSEREARVIAAVNVNRQLLSLVSTRQAPHFQQEKDIVDGAVAVQETLPPEALDSRIEAVALLRGWLRTRVFRKDDNASLLALHDFSTHHDPLPSDEAVKDQRLWSLIYVFGPAPRDLASLAAKPRPEPWSVKGTATTPGDDPTISSYVTADDGVTTIPYRLEGNAAPGAPVVAMSNSLLTSLEMWDPLVQILRRRRPDLAILRYDSRGRHRLPPQSSSAAAAAASGITIDLLASDLNCLLSALRIRRLHALIGVSIGGATTLRFSQLHPERVSRLIGCDFNAVSTPANAQAWRDRARVPLETLAEQTVDRWIHPRNAASVTPWLVPMLAANDPAGFRAASQALYEYDLCPDAPTCEVPTLLVVGDVDAKGAMRAAMAGFAPNLGPRGATLRVVMETGHVPMCEDPEAFWDTIRDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPL7</accession>
    <name>A0A367LPL7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_3161</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPL7"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016694246" evidence="2">
        <location>
            <begin position="20"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI16327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="155" mass="17289" checksum="5BD1BCD6B9D890DC" modified="2018-11-07" version="1">MSLFLLLFTSAAIMNSSRHLQNSHDFPIPCRTCDEYESVPHFVHWQRFWLGLDLTLTTNPPSLLALPGPDNTASPPTTMPSAVIYEGNELSTFKQFVSTMEERLVPPKSENTPRLSAVIFEGNELSTFTQICLDHGGKTGPAQRMNQRPESSPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPV3</accession>
    <name>A0A367LPV3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPV3"/>
    <dbReference type="OrthoDB" id="4203030at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="287" mass="31662" checksum="C62FBA6368C249E5" modified="2018-11-07" version="1" fragment="single">CVVVVVIIVIKLKGRLTHTLFTDAPLPSGLPSSSRSRPRLRLSAMTGALLISRYSAEDLETASMHSMHSTAPSYVSDAPSYHSNPPYPDSAPAYAPTASQTSTTFPRPMLDAGLPSPDTIRPRSVGLPPIPPAMPRSAVSVHNFRLPTWSANNAPAARHYRNVAERRISDGRYNVTETIRRPAVGATSPSPLADNGDVSTVQPRPLEDPYLVGEVAAAQARRERLAREEGDDILIREDRQWDWLLAHMKVCDERQRNLTKFRQNVDTSQRKTLLHRIGGRLLPSTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQ12</accession>
    <name>A0A367LQ12_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Alpha-aminoadipate reductase</fullName>
            <ecNumber evidence="6">1.2.1.31</ecNumber>
            <ecNumber evidence="5">1.2.1.95</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">L-aminoadipate-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">L249_1733</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH. The activated alpha-aminoadipate is bound to the phosphopantheinyl group of the enzyme itself before it is reduced to (S)-2-amino-6-oxohexanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(S)-2-amino-6-oxohexanoate + AMP + diphosphate + NADP(+) = L-2-aminoadipate + ATP + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46936"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="1.2.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(S)-2-amino-6-oxohexanoate + NAD(+) + H2O = L-2-aminoadipate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12308"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="EC" id="1.2.1.31"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>(S)-2-amino-6-oxohexanoate + NADP(+) + H2O = L-2-aminoadipate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12304"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="EC" id="1.2.1.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.31" evidence="6"/>
    <dbReference type="EC" id="1.2.1.95" evidence="5"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQ12"/>
    <dbReference type="STRING" id="1330021.A0A367LQ12"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00032"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004043">
        <property type="term" value="F:L-aminoadipate-semialdehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05235">
        <property type="entry name" value="SDR_e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000787">
        <property type="entry name" value="L-2-aminoadipate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014397">
        <property type="entry name" value="Lys2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03443">
        <property type="entry name" value="alpha_am_amid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845:SF1">
        <property type="entry name" value="L-2-AMINOADIPATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001617">
        <property type="entry name" value="Alpha-AR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="19">
        <location>
            <begin position="629"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00032195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RCI16477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1178" mass="130655" checksum="53990BB20EC6FDA3" modified="2018-11-07" version="1">MAQLPDPTVDLDWSGYAGSIQQHFARQAADHPDRTCVIETSSPEAPERRFTYSHIYQASNVLAHHLTEAGVTNGDVVMIWAHRSVDLVVAIMGTLASGATMSILDPLYPPTRQQIYLEVAQPCALINLARATEEAGPLAPLVRRYIDEDLKLKTEVPSLRIRDDGYLEGGQVDGQDVFAAVRPKAASGPDVLVGPDSNPTLSFTSGSEGRPKGVLGRHYSLVRYFPWMAERFNLSADSKFTLLSGIAHDPVQRDIFTPLFLGAQLLVPCKDDIQHEKLAEWFRQHKPTVTHLTPAMGQILVGGATAEFPALDRAFFVGDVLTTRDCRSLRRLAVNCNIVNMYGTTETQRAVSYFEIPSRAKDPDFLDMLKDTIPAGRGMQNVQLLVVDRQDAKRLCAVGEVGEIYVRAAGLAEGYRGDAALNKQKFLDSWFVDNNSWVQADLKADNGEPWRKYYRGPRDRLYRTGDLGRYLETGDVECTGRADDQVKIRGFRIELNDIDSNLSQSPLIRDCKTLVRRDKNEEPTLVSYVVPELNEWPRFLAAQGLDDVDDQGTEIGPTKVYNTRFRRLQAELRDHLKDRLPSYAVPTTFIVLNKLPLNPNGKVDKPNLPFPDIAEQTRDASDEDRKRWESLTETERLVATRWADLIPGLNAKTISPQNDFFDLGGHSLLAQQMLLVIRKTTGANISINTLYENPSLSSFSARIDRQLGAAAADDDGEEEGRATAYADSLDDLIKELPESFLSADPATIRARAAPTVFLTGATGFLGAYLIKDILDRTSRSLSVIAHVRSVKDPKAALERLCRSLKGYGLWRDEWSTRLACVVGDLTKPRLGVDDESWKMLGEKVDMVIHNGAIVHWVKRYQDMMAANVMSTMDAMRLCNEGKRPKTFTFVSSTSVLDTDHYVELSNKQIGTGQAAVSEDDDMMGSRTGLGTGYGQSKWVSEQLVREAGRRGLRGSVVRPGYILGDSETGVCNTDDFLIRLLKGCIQLGVRPRIVNTVNSVPVNHVARVVVASALNPLADGVHVVHVTGHPRLRMHEYLSLLEYYGYRVSEVSYGDWKDELEKYVSAGGQEKDQEQHALMPLYHFCVNDLPATTRAPELDDRNAVRVLKEDAENWTGVDESAGYGIGREDVGRYLRYLAETMFVGWPSGKGRPLPEVRLGEAQLAAAEAMGGRGGGKGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQ18</accession>
    <name>A0A367LQ18_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQ18"/>
    <dbReference type="STRING" id="1330021.A0A367LQ18"/>
    <dbReference type="OrthoDB" id="5278907at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="142" mass="16780" checksum="A9560621BC5D46A5" modified="2018-11-07" version="1">MLATPIRRLAQAAKEQSALTSAAALTVIRNPYKAKKVWPPKFSELTCQQQLRFEKKLKRRLLLAHQKPKWDKAIKLIQFWAIVATIISFLFFSEFDFWGQEYKPSREMRKYVVTLFGLMDRDKQFENSLHSFPREESNPESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQM9</accession>
    <name>A0A367LQM9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bicarbonate transporter-like transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_2879</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQM9"/>
    <dbReference type="STRING" id="1330021.A0A367LQM9"/>
    <dbReference type="OrthoDB" id="1735926at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080139">
        <property type="term" value="F:borate efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050801">
        <property type="term" value="P:monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.570">
        <property type="entry name" value="Helical hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF82">
        <property type="entry name" value="BORON TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="6">
        <location>
            <begin position="13"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="6">
        <location>
            <begin position="185"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI16650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="521" mass="57623" checksum="2B48A72982B82AC8" modified="2018-11-07" version="1">MSSPASSGTFRPFRLLKQDALNIRSRWLSDWKVMNQQVLASAVYIFFTNLLPGITFASDLYELTGRSWGPIEVVFSTGLCGLIFSIFSAQPLTILGVTGPFSVLAENIYQLCQTSFHVDFLPVMAWTLIHAGWMHLLLAALNAHDWTMRYVTTFSADIFSLLNSVIYFHKAGLELKRTHGAVSLAAFLYAVIGAFGTCLVAVLLSTANSWRPLLHRHLRLGLAEYAAAISIVLWIAIPHIGELDQLDHQRLQVQTQFRPSAPDRTVFLVRFWRLSVSWIFLSIIPAAIVTVLFFFDHEISSIICTSSRYAVRKPGGFAWDVALLGLTTLLCGILGLPPANGLLPQAPLHSESLLYRPDGGQQRRTYEQRYSALIQASLILAFISPPLQRLLGLTQTSVLAGLFMFMGYQSLAVNPILCRVAHLLTPPSDLPALPQAVSWLAIHAFTLTQIALTGAVFAMTLTVAAPAFPLVIVALVPVRLTLMGRMWSRETLRFVDGWACRPGKPEDQRVPARPGDEEKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQR7</accession>
    <name>A0A367LQR7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_1712</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQR7"/>
    <dbReference type="OrthoDB" id="4926019at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017084584" evidence="2">
        <location>
            <begin position="18"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI16768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="238" mass="24962" checksum="0AFD94C1E1FE2396" modified="2018-11-07" version="1">MRYLVGYLALVATVTDAAIIHPRGDGGTFELTDVKPPFQDKLEKGQKYNFLKRRQGGYSVNSDQFKCHGSCGSLITLNKGSAKCKEPDNEALSNICFGTCSNAQPQAVYETAIQVGKDCGFLNEGWKNEEGLNAYTPPQSRPTREAPQEEKPKDSAAAAPSPTTVPADAAPSKPAESSTAPAVKPTEVKPAESTTTPTKPAAKDGGGSPVEVTNSGAKWSVSSSVAVTVAAVVMLVIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQV3</accession>
    <name>A0A367LQV3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_2700</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LQV3"/>
    <dbReference type="OrthoDB" id="377209at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04516">
        <property type="entry name" value="TBP_eukaryotes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000001">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000002">
        <property type="entry name" value="TATA-box-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
        <property type="entry name" value="Surp module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00408">
        <property type="entry name" value="TATA_bind_prot_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030491">
        <property type="entry name" value="TBP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033710">
        <property type="entry name" value="TBP_eukaryotic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00351">
        <property type="entry name" value="TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="CID" evidence="7">
        <location>
            <begin position="1222"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="76"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="817"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1036"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1283"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1409"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1492"/>
            <end position="1534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1442"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1469"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1492"/>
            <end position="1501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI16835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1534" mass="166974" checksum="CCB5417A96C98729" modified="2018-11-07" version="1">MNGKPLGMAAVVEARIALAEAQWKFQDVEQRSAQRHLHVICICLVAWEKMEGIQTHPSNAAQAKAFTAPGSLSFPGATNELTPPFGDGSQHSSVNAQPAAGGNGVTPATPAATPAATPAATQGPSGITPTLQNIVATVNLDCRLDLKTIALHARNAEYNPKRFAAVIMRIRDPKTTALIFASGKMVVTGAKSEDDSKLASRKYARIIQKLGFNAKFTDFKIQNIVGSCDIKFPIRLEGLASRHHNFSSYEPELFPGLIYRMIKPKIVLLIFVSGKIVLTGAKVREEIYQAFEMIYPVLQGFHSSFSISSPLLELSSMDNILVIGSGVFGLSTASSLAKKHFFDGTAITVVDCAAHDGQLPPPDAASVDHSRIVRPDYANPDYVALAMLAQKEWRKQGDGELGGQQRYVESGLVLTANRSRSGEYVTRALEEVRKRYENVVHEKHHIRTFETKEALGNYLGTTGHAGDWGYLNAGSGWADAEKAMQWLYEQVKASKRVSFVNAKVKQLETQDDRVIGARLSDDTVLKADVVILAAGAWTGDFVDLRGRVEATGQVMGYVDLTHEEAAVMAKQPALLSLATGLFVIPPRGRVLKVARHGLGYLNPQVVTSALPTTAAARQEPILISRPATRRDGAGRLPPDAEADLRSGLRDLTPIAGLETRPWRETRICWYSDTKDGHFLVDWHPGWKGLFVATGGSGHGFKFLPVLGDKVVDCLMGCGDELCRKWKWRAAGDEGEGRETGGRYRGLQTLDQSRAGVSGRVLEEELKKTGSGDVEAKLAKPVKQSAFERAKAEAEAKRKRDEAETAAVYEEFVRSFEQDDDHGGRRGGFQAPQRPRNHFGGPPPASSLATGKRHFAMTGSKKSGPGTLGPVPTSYGTKRSFNEYSGAEQRGRLAGSYHQDAAAGSMSVSEAFKDVSDDEDDVQRDAMERAELKAIAKAQLMLSNMPPGTSPAAIKALIPDTLTVDAVRIEPPTGPGSEKKRINAVATLSRECSGSALDAAVSTLHNRYLGCGFYLSVHRHLSSAVLNTLSTLPSSSSAAQPFGAKRAEQKPAPNRVGGPHGYRGGFAPPSSYHHAGGGSRTSRFYVPVTAPDDIRMLRLIHKTVESVLEHGHEFEALLMSRPEVQREEKWAWLWDSTSVGGVWYRWRLWEMTTECRVQPRREPHIGILEDSSPWQVPDSLPFEFVGRLDEFVSDTEYNSSDDEDVDRDAARENNMGEVERPFLTPLEKAKLVHLLARLPVSLTKIKKGDVARVTAFALMHADRGPGEVVDLIVSNIGRPFAFTGAGGEGKNTETKEARQATGTEDGSAAMEGPDTSAGSLIGLYVVSDILSSSSTTVFRHAWRFRGQFEKALKDHQVFEFLGTMPEKHGWGRLRAEKWKRSIGLVLNLWEGWCVFPGKAHEQFVSAFEKPPPIKTDEASTKGKSTLPEAPTTVNEEAAPSTGVEREVKEQQKDDVMDDKDKGDVMGDKDGDGDDVMGEPLNDEDIMKVLLAGRGGSASGEGGEATANEEVSENGRGRKRMRAVDMFAESDDSEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQX5</accession>
    <name>A0A367LQX5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_2027</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQX5"/>
    <dbReference type="STRING" id="1330021.A0A367LQX5"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="286"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="319"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="352"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="430"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI16787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="439" mass="48650" checksum="532E7C297CFAD443" modified="2018-11-07" version="1">MISLQTTPIPTCERPRPDILTTDSGPDGVQAREQLASFNIWTKVIGVFRHDRHSLMCRLKGEPNIKKLVGRLLHSLESDLSNYQSGQAEEGTSSDNDSHQSSDRSIVYSDKSLLSLEEHGEASPPHQPEIWTSIRDTIISLRQLGQNVDQAANQHFQKQIQQFKLRPDIGELFHLFKRCARQKVYHVFPNASASLRNRMAQSIATRRVRFIYLAEHQTKLSTLCKHEENPNGAEAFSPVGHRDGTFVRQGRLSIGWKGGGGVQRGQEAIVTLLVDRGADINIPDRDHQTPLLRATRMGYEDIVKLLVDQGAYIDTLDRDGRTPLSWAAQGGHDAIVRLLTDRGGNINTLDKDLQTPLIWATKTGDEACVRILIDRSAELDAISKHGESALTIAAKEGHDAIFKLLLDRAGQEIAGLTQRSAGHGRRKGGQKAGGQGISW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LR96</accession>
    <name>A0A367LR96_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_3079</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LR96"/>
    <dbReference type="OrthoDB" id="5283415at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="51"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI16974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="389" mass="42101" checksum="335541264CE6CE1A" modified="2018-11-07" version="1">MEDSLRIDEAIAAGRVPAEITADFLRESHDGPAMVGIMLVMMLTAAIVVCRLLARTLMLQRFGFDDGLALASLLTLAAFVGLCMELIRLGSGRHYAYIQYVLDLQTVERTQILDFAAHILYTVALLLCRVSGLAFYHRVCGLHGGFLVGIHVVFGLLMAGFLPQLLLIVLHCQPVTALWPYGWEPDSAVYKCLQWGVVYVTNSTISLICDMLLFGIPVAMLRILEMPQRRKIQLGCILLPGIAVVAISITRLVLVVIGQWEMDMSWSYNALLAVEVSEIGATLIALSVPGVKPLVDRFILRKDNTSQTAGGSKYMPSPGSHTSKGTALSTLKLRSDYSVLGAEAAGNYGTEVSAGSHGGSVSQEGIHVTVDFHVNDGESKRLAAVQQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRC0</accession>
    <name>A0A367LRC0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">t-SNARE affecting a late Golgi compartment protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_2061</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRC0"/>
    <dbReference type="STRING" id="1330021.A0A367LRC0"/>
    <dbReference type="OrthoDB" id="546861at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21444">
        <property type="entry name" value="SNARE_NTD_Tlg1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15851">
        <property type="entry name" value="SNARE_Syntaxin6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.90:FF:000012">
        <property type="entry name" value="SNARE domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000006">
        <property type="entry name" value="Syntaxin 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015260">
        <property type="entry name" value="Syntaxin-6/10/61_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048036">
        <property type="entry name" value="Tlg1p-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09177">
        <property type="entry name" value="STX6_10_61_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="13">
        <location>
            <begin position="147"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI16961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="239" mass="26932" checksum="C00101E2230BFB0D" modified="2018-11-07" version="1">MMSSTNEDADPFIQVQQDVLNQLSSTRPLFASYLRIRSLSSTTTSPELASARNDLENALKTLAEDLTDLELSVRAAESNPSQYGLSADEVSRRKRLVQETSGEMDDMREELARNINSSASLSGRNANPARDDNEEDYAAGFEQEQQVQMMRDQDQHLDGVFQTVGNLRRQADDMGRELGEQHEMLEMVDQSADRVGSRLQNGMQKLQYVVRNNEDRWSSCCIAVLIFVLILLLILLLIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRE0</accession>
    <name>A0A367LRE0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_3076</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NRP synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LRE0"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031169">
        <property type="term" value="P:ferrichrome biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.980:FF:000001">
        <property type="entry name" value="Non-ribosomal peptide synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000033">
        <property type="entry name" value="Nonribosomal siderophore peptide synthase SidC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000024">
        <property type="entry name" value="Nonribosomal siderophore peptide synthase SidC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003417">
        <property type="entry name" value="PRK04813.1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="1624"/>
            <end position="1702"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="2172"/>
            <end position="2248"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="3258"/>
            <end position="3332"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="3796"/>
            <end position="3869"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="4366"/>
            <end position="4440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="4805"/>
            <end position="4838"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI16981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="4877" mass="538776" checksum="ED4C74C1C5CEAEC0" modified="2018-11-07" version="1">[encoded data, 4877 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRK3</accession>
    <name>A0A367LRK3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ZP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_2323</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRK3"/>
    <dbReference type="STRING" id="1330021.A0A367LRK3"/>
    <dbReference type="OrthoDB" id="4915302at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016719688" description="ZP domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="747"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI17049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="810" mass="89085" checksum="4EC50C7A9C3843DD" modified="2018-11-07" version="1">MKGLVVLGLHALLARSYQYHSQGPDLFQNYLTNVSVLGHSFSEPKLIEEWHDNDCDKAITNYVMPYGLADSLCKTVIHSGKVDVDGILRGQASDTAYHVRDGCDLNRAGRVCRVLQARGVVGEMHETGSFCYSSLRRELHRQPGKVWELCRDHIVNNVVTQVNHSEPKPRTEMVFSDCFHSQFELARACEMLEPPKVLASEHCASTFGYYHVVFLFGNALDRFCRNDRPELKIPYRIEKALEKKTSRQAQRAIKDSCHCHNLHGHERRQHGQGHPHGDDGNVSGSHPDRPTWPASNVAGINRRQDWNDANRNQPSWSNRNRPAGSYGRDGWQDTNRPRSYDPQQQQPSWSNRGNMPGVFPASRDWNGPNRNGFHNQQPWSGPGMHGMRTPWSGPGMTPHGYGATPYVPQGPVLTEADVEKLLQLSKMFKFEIRSGLFAIQDMPQPARDAGVSWRLVYDLDVDVKAQPRLRFELCDAREQGRVVTKIRDQYVYGYPLEVNGQALATASISATGQNELLCDNGDLTYVKIKNKSVPDFRPADEAVAARRRGQFIKCDDINKCQESRCEGDSCSFNLVASVTVEAKTGDSTSAATATATARASFKFDFEPCQTPKTCNCVRTCAENNNCMVQRPIQGLAPAPVPREQVRGATVADLAHVIAAAKAGHDDRGAYAAAEAEAGFERGRDVAGMRGSRGAGFGPGFDGPRFPGDGRAGAAPISGHVEVQGEVMVGGKPSSNMYDSRYPTHNSTADRFGRMGNKGLGQQPGWNPSDDRSRTVDNFDNADGSVVFAGCGHVAVALNILIGAVGLAVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRV1</accession>
    <name>A0A367LRV1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein SDA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_3190</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for 60S pre-ribosomal subunits export to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the SDA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRV1"/>
    <dbReference type="STRING" id="1330021.A0A367LRV1"/>
    <dbReference type="OrthoDB" id="2196187at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027312">
        <property type="entry name" value="Sda1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048292">
        <property type="entry name" value="SDA1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007949">
        <property type="entry name" value="SDA1_MD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012977">
        <property type="entry name" value="SDA1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12730">
        <property type="entry name" value="HSDA/SDA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12730:SF0">
        <property type="entry name" value="PROTEIN SDA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21638">
        <property type="entry name" value="SDA1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05285">
        <property type="entry name" value="SDA1_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08158">
        <property type="entry name" value="SDA1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="SDA1 N-terminal" evidence="9">
        <location>
            <begin position="70"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="SDA1 middle" evidence="8">
        <location>
            <begin position="542"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="SDA1 C-terminal" evidence="10">
        <location>
            <begin position="689"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="505"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="517"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="566"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="630"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="654"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="684"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="716"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI17176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="741" mass="83211" checksum="46B82F2EA2BC90C8" modified="2018-11-07" version="1">MGKRKVAALEKLDADFASLQYKIRRDPRSYKDDFLRQWEQYVSQREIFLSSPTTATADSVESFHNMVDLIAHVADCYPDETRTFPDDLRLILTQHHAAIHPDLREKVVGSLVLLRRKDVIDSASLLTTLFPILVSSSSKTLRELLFNKILSDMRNSNTRAINHPLNRTIQTVLYNLVVADRTSPRAIWAIKLTRELWKRQIWTDAKPVDVMKEACLADNEKVAVGAARFFLGGDKEREELEDESSDEEVDLGKVRHQITINKKSKKQKDALKKAVSKVKRNERKKSKPHPLNFSALHLLHDPQTFTEQLFSKHLQNNKAKLALESKLLILQLVTRLVGLHRLTVVALYSWFIKFLTPRQQSVTSFLASLAQGTHDLVPPDVLEPLLQKIANEFVSEASASEVAAAGLNAIREICARQPLAMTETLLQDLVQYRKSKDKGVMMAAKGLLSLYREVGAELLKRRDRGKDASIGLKSGLQQQRKFGEEQAGGIQGLDLLAKYKEEERKRKRAEAGLPETETGDAAEDDGFNSSEWEVGSDDSDGSSGGEWINVEHSDDEEPAVKRQKKKAADDDGSHDGHDSDGDNEEREADLERMSRLATTTILTPADLAKLQELRTAAAVESAMGGKRAKKADERHKDDGLTAENIEAPAKLRKLSKEEKLALAKEGKPDREEHKSTQAIRKSKKEAAGKSTSNREKQRKKNFLMTLGKAKSKQKRSLVDARKVLRGHVERSSRGGRRRNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRY2</accession>
    <name>A0A367LRY2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TatD related DNase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_2305</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRY2"/>
    <dbReference type="STRING" id="1330021.A0A367LRY2"/>
    <dbReference type="OrthoDB" id="6079689at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050891">
        <property type="entry name" value="TatD-type_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060:SF15">
        <property type="entry name" value="DEOXYRIBONUCLEASE TATDN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060">
        <property type="entry name" value="TATD FAMILY DEOXYRIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01091">
        <property type="entry name" value="TATD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="428"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="283"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="437"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="466"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="485"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="516"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="532"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="567"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI16992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="578" mass="64950" checksum="71EEEF676FCCBA1A" modified="2018-11-07" version="1">MASPTTRDEPYKPRYVDIGINLTDPVFKGLYHGKPRHPPDVQAVINRASEVGCSKLIVTGSHIKNTWEALKLAEEYPTVYATAGIHPCTSSVFSDQSPLDTREIIVDSEKSKAIEIELRALIEHARTIYPQNLVAMGEFGLDYDRLEHCNKTVQLHSFKTQLKIAASLSPQLPLFLHCRAAHKDFVSLLKGTFGSRLEKLHGGGVVHSFTGTYEEMMELHELGLYIGVNGCSLKTKENCDVVSKIPLQSIMLETDGPWCEVRPGHEGWRRYVAIKAAQKSEAENSQGPETEQPQKPSQDKAQAVGGIPSRYKIVKKERWVKDALIKFRNEPCNIELVAQIVAALKGVSVEDICEAAWANTEGLFVLADKQTEGGEVAWQDGDTDYGGDVYNARGFHKGRYVGPRRHHRRRTNEAIFPDHRNVWAKTADAGDESVVPVEHEAHGKEMKPDDDGAEMKPDDDGAEMKPDDDDEEVELDLEGMKLNDEEIGPDDDFDENEQGFDKPPGGRAEMDYLLQKLREEDRREAERGINQSDDDDGYEVTADDENQEFESQFNEGERDVDLPSLRPGRRRSSRRRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LSF6</accession>
    <name>A0A367LSF6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_2468</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LSF6"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI17290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="215" mass="23839" checksum="0FB3903897EA6ED0" modified="2018-11-07" version="1">MQARIPCPEHTICTDTILPYHGMEKGRYDMPFPCASHWPPQRSNLPSFGVQTEDEREESEMKGPINTAAQGYCTASAAFVSRCRSHDSFIPFKGKHVCVIPSSPPFPFPSFHPPPSLPSSLTFPPACRGSRAVIDVVVVVVVVVSRLSVRDISPLPQRKKKGVGESEGDASSCVSLEWGPTRQKKCMTLFVSINPYPAEMEYYVKLTIRTDLTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LSJ5</accession>
    <name>A0A367LSJ5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">HMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_2675</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LSJ5"/>
    <dbReference type="STRING" id="1330021.A0A367LSJ5"/>
    <dbReference type="OrthoDB" id="432719at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000068">
        <property type="entry name" value="Copper resistance-associated P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000043">
        <property type="entry name" value="Copper-transporting ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF32">
        <property type="entry name" value="COPPER RESISTANCE P-TYPE ATPASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="422"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="508"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="664"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="707"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1066"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1099"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="12">
        <location>
            <begin position="201"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="976"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="979"/>
            <end position="991"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI17388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1125" mass="120240" checksum="517EB52927159016" modified="2018-11-07" version="1">MAPSSKTVTTSFLLGNLHCPSCVALIKRLLHDEYRQKMLWVSPNVVTSVVTVEHEDASPDFIRSMGRTLNDVGFDICAVDSSAVQAADLNAIAQDEENPPAASGYRTFDLWSRLWRNKSSPASDPTSLAAAHLQNCEACKSATGHEQSRMSEDRIRLVRTLSLASSTQEGSPTTATTMTMPLEGVLVPGEDAINDGAPPLMRATLSIGGMTCAVCVNTISGEVRKNPWVSNIVVNLVSNSATVDFTDPNRARDIVDAIEDLGYDAVLNSVVDVKKQRRAAAEREMEIQVDGIFCPRCPDRICQSLRNLGPGRVEVLQEPTLELPRLRVRYLPDVPLLTIRHILGAIEATDPSLSASVYHPPTLEERSRAIRARHQRQLFRRQMLTAVIAVPTFVLGIVYMSLVPESDPVRRFLMEPWTSGLSLNEVMLCLLATPVYFFAADVFHVRAVKELRTLWRGNSRTPLLQRFYKFGSMNMLISLGTTIAYFSSVAEMVAAAVRHETHVPESRFYFDSVVFLTLFLLAGRLIEGYSKSKTGDAVEALAKLRPSTALLIETDKLGSAQTRVVKVDLLEHGDMIRVPNGSSPPADGVIVTGETSLDESSLTGESRPIKKRPGDEVYAGTVNKGDAVTVRVTGTCGRSMLDQIVEVVREGQTKRAPVEQVADLLTSYFVPVVTLVAVVTWITWLVLAMTGRVSDEQLNRSGGSAAFAFQFAIAVFVVACPCGLALAAPTAIFVGGGIAAQNGILAKGGGEAFEKASKIDCVVFDKTGTLTVGGEPRVTDSVLFPSGSIDGVDERTLLSGLKATEENSGHPMARAAVRFCGPRVESAPLAKVEELPGKGMRAAYSDAAGTELAVGNEHLMRDLPAALPAHVVDVLAVWKGEAKSVALVAARTSEGGGKWKLAGALAVSDPVRPEAVAVVRALRRRGTDVWMLSGDNETTAQAVGRQVGIAAANVLAEVLPSEKAAKVAMLQATLHGGDGEDVGGDDDDDDDDNRHSTGRRGMVAMVGDGINDAPALTRADVGIAIGSGSDVAISSADFVLATSKLSAVVTLLDLSSAVLRRIKVNFCWALVYNVLAVPVAAGCLWPVRTSSGGHVRLDPVWAALAMALSSISVVLSSLSLRSRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZ64</accession>
    <name>A0A367KZ64_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="7">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_4523</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="7"/>
    <dbReference type="EMBL" id="LKCN02000028">
        <property type="protein sequence ID" value="RCI07457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZ64"/>
    <dbReference type="STRING" id="1330021.A0A367KZ64"/>
    <dbReference type="OrthoDB" id="407390at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF25">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Branched-chain alpha-ketoacid dehydrogenase kinase/Pyruvate dehydrogenase kinase N-terminal" evidence="8">
        <location>
            <begin position="91"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI07457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="462" mass="51447" checksum="304F582F2C3223A2" modified="2018-11-07" version="1">MFAMPLRCARCRVFTGFSPTPLLSSVASRSASSNAITSSTSAWRPVSVLDEWVAREARPISLRQLMVFGRSLTESRLISSANYVRTELPVRSANYVRTELPVRIAHRIRDMQRLPYAVVTNQHIHEVYSLYFNAFDTFRKIPEIKTLEDNDRLCEVISQTLKSHLTVIPKLAMGILECGGLMDPVELDRFMNIILRSRISRRVIAEQHLSLTETFNSPYFSAGAKLSEADFIGQVFIKCSAKDVINRCAEAVTALARSSNGPDVAVPPIRVLGHLDASFPYILSHIDYIVGELLRNSVQAVIDRYSDNTDASSVPPVDVTVCEAQEHVIFRISDQGGGISRHQLPYLWSFSKGPQSQARLRNLGQVPRMAATTQDLHVREELARADLKAPSVYQSSLSSLAVRSPNLRLGIGLPLSRVYAEYWAGSLNIHNLEGYGVDAFLQISRLGNKNEQLTTRASMDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZM0</accession>
    <name>A0A367KZM0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit DAM1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Outer kinetochore protein DAM1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L249_1678</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex DAM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000026">
        <property type="protein sequence ID" value="RCI07620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZM0"/>
    <dbReference type="STRING" id="1330021.A0A367KZM0"/>
    <dbReference type="OrthoDB" id="5586015at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990537">
        <property type="term" value="C:mitotic spindle polar microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990758">
        <property type="term" value="P:mitotic sister chromatid biorientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013962">
        <property type="entry name" value="DASH_Dam1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28113">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28113:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT DAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08653">
        <property type="entry name" value="DASH_Dam1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="109"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="147"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCI07620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="197" mass="21745" checksum="0EF1B80F151DD959" modified="2018-11-07" version="1">MTSEARENTAAKRPNSRTRPNTPLRASSRSSFHDSIRGADETDGSLPLNIFEPAFAELSDAMADLEANMMHFQLMHESLARFSESFSSFLYGLNMNAFCVDFPEGPLPESFRRDRQQDGIQARDTPRQDHEAEATFMTTDMSFVDNPSVSAKSSSKPATPEARSSRLPYAPGTSSRGRGRGRGRPSGLARPRGRGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZQ3</accession>
    <name>A0A367KZQ3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5908</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000025">
        <property type="protein sequence ID" value="RCI07659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZQ3"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI07659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="61" mass="7314" checksum="1F214FEF3226C05A" modified="2018-11-07" version="1" fragment="single">EEEEESRNSLKEEIKEELEAGEVFVLRRYFSRYFKVPTCSTLTYLYTCSDLTDRINLIRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L003</accession>
    <name>A0A367L003_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Heat-labile enterotoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_5747</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000024">
        <property type="protein sequence ID" value="RCI07744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L003"/>
    <dbReference type="STRING" id="1330021.A0A367L003"/>
    <dbReference type="OrthoDB" id="432447at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.40">
        <property type="entry name" value="Diphtheria toxin, translocation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.210.10">
        <property type="entry name" value="Heat-Labile Enterotoxin, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001144">
        <property type="entry name" value="Enterotoxin_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01375">
        <property type="entry name" value="Enterotoxin_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22785">
        <property type="entry name" value="Tc-R-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0800">Toxin</keyword>
    <keyword evidence="3" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016752978" evidence="6">
        <location>
            <begin position="35"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="471"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="547"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="486"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="558"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI07744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1051" mass="118249" checksum="FEFF8BD77CB7BE68" modified="2018-11-07" version="1">MARPFKSSPFSGGLCASLLCLCVVHLLGLDKALFLGNNRDPFLKARAVEQNETLEEARTPIRRAVMSPNYIDMDEAGLYRFQQVTQFLEPSDQLYRSSAPFYTGEDTSHQAKEITRDALKQRNIKTVISLNSDAGNPKFRTVFGPDIAYKAVPVQDYTAPTPKELQRITDIFMGNRKRGGVLVWCGYGHGRTGTAISAIQIRVQAELPGLKHAKLARADFEANHVETDKQLQVLEDYQREIPAYRGFNPFKSALVHDNGVTVPLLLHFAESMPTSAVANVDHHGLEAVELHTTTPKVVLRGEELRRPDDILAAGGFRSRGYLALESGHFLTDDQMERSSSLYFHAEEKTLHSRYIATTTDARTALVSSDTLRSLDEVGYIYRIRADEKMIHLSGSIGNYSSRTNRFEHPAVWFIPADQIEGWYNVTTDKVGLHKDDPTRRSFIDRVQAGSAEGFEANPQFKREKYTSQRGFGPLPRLAGFPKRRPHEVGEQGKDGPIARHLSEGEEKAVSAWDEAEWQDFRHESVRDALEGLIEATGGMRSVSLVKRGKPCKTGQGPDGERSSTDGKSRKDLLGFSALAEKTKVSLPEMHRRLRQTTLAIKRVKSPLAANVVTFGPWVAGIVRVFEEESSVLQRAAAITSIVPVAGCFVQYAADSQVGQGDKLDTALCAIGDALMLNPILLPIGVVVHAARIAVQSVPDFWNTLKATYAPSVLYGRRLEGWKSILKEIAKNVTSPEFASDLKTSFHFDVAAVASTLSEAKANLILGRIDASRKASKEEKRKITKAYAKTLKELNRKACGELSKRIERFQKDTRHTMEEILRNSSQIYDDEFFTDFRRRADQNSLLMIMFSWSVNDKLLRLIEKVRKISLHPNGNFLQGLEETLQTEHRQKLNDVVKKSASDTFPHDPAKCVALFEADDEKDVESGLEFIDEPPRCVKKSPRKKGSKRDCIHWREVISTLKKEDVTDCNDEGLWTYRESMTKLINGQLNCGTADDHWSWDQGTRLKHCRIRHGFQYCDFYKHKTMDHKTKMQAYNTGLILEQPPKIVWNGQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0I2</accession>
    <name>A0A367L0I2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000023">
        <property type="protein sequence ID" value="RCI07921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0I2"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI07921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="155" mass="17931" checksum="254CCC0BA37C01AA" modified="2018-11-07" version="1">MTVEELRFHPPLQTAPVYCPPIVWYNDTCLFKRESDDRQRVRRNEKHGLTTAEEERRSKEAKRSCAPTPHPLFCAEALPVFVSPRGPTSRFTRRHVVFFFFSLFSRPGKALTRGAPVQSPQRPRAGKGKKEKKKKRIGEHSIERARTVRCDGTDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L103</accession>
    <name>A0A367L103_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L103"/>
    <dbReference type="OrthoDB" id="4907387at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016810802" evidence="1">
        <location>
            <begin position="16"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="285" mass="32743" checksum="A87C4518BE00070D" modified="2018-11-07" version="1">MLIASLFCLAGGASAIKYQCSKDFEPRQLLSVFGAVRYCGTPISLMQQACYDRLIQRSLTSYSVGYHMAAWERQTSTSFESLRYMHHLDVAQDHNWWSSIISALEDNHDICWYVRDYSADQYSKGSISGHLGSVFFVDNPFREPLMHVETDPRKVQVRNGNQCFSPDEDFKESRIKAISILLTGYNSEGVTSLSMTYRAFNGRVSTDLLLSATLARLVRNYRCPSGIRCVSKLVEGRPYLPESPKDFLRRVLSIIERDATLCFQETPMACHVERWYYLTGFDYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L169</accession>
    <name>A0A367L169_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Survival protein SurE-like phosphatase/nucleotidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_6208</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L169"/>
    <dbReference type="STRING" id="1330021.A0A367L169"/>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="entry name" value="Survival protein SurE-like phosphatase/nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027746">
        <property type="entry name" value="TTL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00087">
        <property type="entry name" value="surE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551:SF1">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SurE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Survival protein SurE-like phosphatase/nucleotidase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="700"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="704"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI08161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="877" mass="97654" checksum="50F29C33034EB3ED" modified="2018-11-07" version="1">MHILVTNDDGPPSSESSPYVLCLVRHLQRAGHVVSVCLPHTQRSWIAKAHMIGQTLKPLYYRPDPGLHGQGSTHQRPSPEARVEEWILIDGTPASCVQIGLNHFFQDRGPIDLVVSGPNFGRNTSSVFALSSGTLGAAMEAAVCRQKSIALSFAFFSRNHDPTIIEAACRHSLRVIEALYRRWPTDGAADLYSVNVPLVDDVERNKTLWTDMLQNYWSGGSCFEEIDDDAALDATHEELLIREGPGGEAAAAAATATVVDKPAGHTHKHFKWAPRLANVYKSVAESGPGNDGRTVKEGNTSITPLKANFAQGTGAFSRQEFELKPLWTGLLRQKLAVESKTKFDMAKNRMYITWPCFFFFFNLWISNRPPSYRTPHRSEGHDRVVGGTKITTPLRAVVAYDDAYVQPLIVSALRSILPDDALSFVTEYHATEQGLAVAAAAAAAVSASDLLSKKPEPRILQITAYESIDFEYAAAHTRSCLVNSYMIRKALIRKHFLSATVDHWLAKKPKSPLATHFKRCEAWELDYAEFLDDALVEAFDLRASMERNALRRLSRQEEGKAEAEWWILKPGMSDGGHGIRLFSTMEELQAIFDEWEGGDDDEEHDDGDDDDDDDDCVTTSHLRHFVAQPYIHPPLLLESDPRKFHIRAYVLSVGSLKVYVYKPMLALFAAKPYQPPWVHDANASDRFLTNTCLFALREQQAKGDEEEEKEEEEEEDDNDTKRAATSVAGDRVRAFWDLSSSSSSSSSSSSSSSSLLPRERLDDIFAQICRVTSDVFDAAAKAMPVHFQPLPNAFEVFGLDFLVDADGVAWLLEVNAFPDFKQTGRALEPLVRGFWDGVVRKAVLPFFRLGSGVEGEEEEEEDEDDMVLVGKIDIGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1I4</accession>
    <name>A0A367L1I4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Nucleolar GTP-binding protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_8363</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
            <location evidence="2 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000020">
        <property type="protein sequence ID" value="RCI08276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1I4"/>
    <dbReference type="STRING" id="1330021.A0A367L1I4"/>
    <dbReference type="OrthoDB" id="444945at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01858">
        <property type="entry name" value="NGP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024929">
        <property type="entry name" value="GNL2_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012971">
        <property type="entry name" value="NOG2_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF9">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08153">
        <property type="entry name" value="NGP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="9">
        <location>
            <begin position="249"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI08276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="555" mass="62291" checksum="355069B66B233E6C" modified="2018-11-07" version="1" fragment="single">AGHRPCSYGCQNLSKLEPYSTVPPGISVASNTKSRVGRAMGTDKKEANRRARHSKATDNFGNVRRKGENFYRDAKKVKILSMYKQGNTQRDSQGNITKCASYQSREVPEARIEPNRRWFTNTRTVSQHSLQAFRVALAGRSHNPYEILLKSNKLPLDLVSDERNDSSGVHQRHGLSSTGSFSFTHIFGPKSQRKRVNLGVESLVHLADSTLEIVREEHTSIKNSVYHGCNPSSTSAGPVFDKGQSKRIWNELYKVVDSSDVVLLVLDARDPLGTRCRTIEKYLGQEAPHKHLILILNKCDLIPTGIAVPFRNPFRGRDRLAWRFYSHDPHILFVYLWHLGGFRVTNDSRQASWVRRLSREYPTLAFHASITNSFGKGSLITLLRQFCSLHSNRKQISVGVIGAPNTGKSSIINTLLKKKVCSVAPIPGETKVWQYVSLTRRIYLIDSPGVVPPSSSDSPTDLLLRGVVRMEKVQDPEQYIGAVLDRVKRQHMEKTYGLRVRGSETEFLEALAQKSGRLLRGGEPDISGVAKMVLNDFVRGKIPWFTPLPNIEAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1M1</accession>
    <name>A0A367L1M1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Bul1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1M1"/>
    <dbReference type="STRING" id="1330021.A0A367L1M1"/>
    <dbReference type="OrthoDB" id="2283785at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039634">
        <property type="entry name" value="Bul1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31904">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31904:SF1">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="492" mass="54062" checksum="8B833DCAB10A0ACB" modified="2018-11-07" version="1">MVPQHNVEAVIPRLTSRSKPAAQQKPSISIEINGHFSSKVYNSGSAISGSVIICTQRPTPFHDLDIIFTGIAATRLDFVQQYPSHSFRPFMKLRMPIRRSALPEPKVFEAGKLYSIPFNFVVPHQLTLGACTHPCSSPAVREHHLRLPPTVGFWEADDQAPEMAQIEYSIKARVYRMTEPGGYQQKFMEGYHMLKVLPALPEDAPLDITARDERYSLHKSKTIRKSLFSAKAGKLIVKASQPGAIMLTPDAHSASTSTVRIALEFFPASPHHAPPKISFASGKLTSATFFGAAPTDLLPNLGSRSVYTANPSLSYTTTTSLFSRPLVGLTWHQRSTAGRRDSGYSSLSVDEDASETDCSEARGGRRSGRCPVRHSSLVEMAFTIPMTNRKLFLPTFHSCLISRTYTLHVSLSVGPANAAVNLAIPLQIGVDAVHQPHLADGLPSFETAMAEDEEADADAHLQPRIMRIPESLVQQRMLPGYDDLSRRVIAVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1N4</accession>
    <name>A0A367L1N4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_8888</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1N4"/>
    <dbReference type="STRING" id="1330021.A0A367L1N4"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20353">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16630">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051628">
        <property type="entry name" value="LUBAC_E3_Ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047546">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047544">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770:SF42">
        <property type="entry name" value="FINGER PROTEIN (ZIN), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770">
        <property type="entry name" value="UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26200">
        <property type="entry name" value="Rcat_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26191">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="397"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="260"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI08350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="643" mass="71363" checksum="009CBB8F4D0D9C7B" modified="2018-11-07" version="1">MVFSGLLSSGGDKASASRVRSGSDTLIYDESQLPCVPPERPNLRDLNTSLEALAAIFPDVQIDVFRELLSNFDGESRLALVAEALLKNRVAWVKGRWRSVADRQADSATGALSLAKADSFRSPEYVQAVRTLACHEFRGLSRSTIHAVLAESNHSYLDARRTLVSLSSQSWRFTISSIILRRRKPLGTGEAEHHPLVLWRPTTDGGALPAIRPTGSAELDRELYDALVRPIKVRDREARDATDRRLAVRLNYDEAERADAMYECACCFSSTVFEEFTSCNQAGHMVCFRCVLHATKEALFGQAWLSSIDPDMGTLKCLAVDGDGCAGHIPPDHLHRALMDDRTGSDMVYRLDQRLAEHSLVASRLPLVRCPFCSYTEVDDVYAPGGQSRPRLKVDDVFGLVLLVLAAAFLVLSLPVALLSSLACVAIGSDRSAWRLVRTEWNRALGRLYRRRRGLRFSCQGPSCGRLSCLSCHKPWTDVHVCNESSLVALRTQVEQAMSMAIKRVCPRCNTSFVKNTGCNKLTCPCGYKMCYVCRADLRDEGYRHFCDHFRPDGDPKPCRECDRCNLWESEDVDRVLQEARADAERRWKDKERRSLSGAEVAYLETGVAGRRSAAAGVGRILGGGGIPAWPELLDLVVDALYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L280</accession>
    <name>A0A367L280_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial</fullName>
            <ecNumber evidence="6">1.1.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Isocitric dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">NAD(+)-specific ICDH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L249_8926</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:23632"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.41"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Octamer of two non-identical subunits IDH1 and IDH2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.41" evidence="6"/>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L280"/>
    <dbReference type="STRING" id="1330021.A0A367L280"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000003">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF34">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="15">
        <location>
            <begin position="44"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCI08539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="373" mass="40102" checksum="629E889DD7ECF9D6" modified="2018-11-07" version="1">MLALRASSRPCFRAAATAASRFYSSAGERVAKYEGTKNSEGNYLVSLIEGDGIGPEISQSVKEIFAAAKTPVAWESIDVTPVLKDGKTAIPDEAITSIRKNKIALKGPLATPVGKGHVSLNLTLRRTFNLFANLRPCRSVAGYKTPYNDVDTVLIRENTEGEYSGIEHIVVDGVVQSIKLITREASERVLRFAFQHAEAIGRKKVRVVHKATIMKMSDGLFLNVARRVAKDFPGIEFDAELLDNTCLKMVTDPTPYNDKVLVMPNLYGDILSDMCAGLIGGLGLTPSGNIGDVCSIFEAVHGSAPDIAGKGLANPTALLLSSIMMLRHMRLNGDAGRIEKAIFDTLADGKVLTGDLGGKAKTHEYAAAIISRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L290</accession>
    <name>A0A367L290_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nuclear cap-binding protein subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">20 kDa nuclear cap-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_8774</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the RRM NCBP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L290"/>
    <dbReference type="STRING" id="1330021.A0A367L290"/>
    <dbReference type="OrthoDB" id="201398at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005846">
        <property type="term" value="C:nuclear cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12240">
        <property type="entry name" value="RRM_NCBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000399">
        <property type="entry name" value="Nuclear cap-binding protein subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027157">
        <property type="entry name" value="NCBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034148">
        <property type="entry name" value="NCBP2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847">
        <property type="entry name" value="20 KD NUCLEAR CAP BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847:SF0">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="52"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="133"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI08549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="181" mass="20987" checksum="F302AEB608B98B39" modified="2018-11-07" version="1">MRGGPRNTVDRLDRPSAYHQSRNKRRRDREEDDVAAEETTTEPVPDPLADATTLYVGNLSFYTTEEQVYELFSKCGDIKRLIMGLDRFQKTPCGFCFVEYYTHQDALDCMKYIGGTKLDERIIRTDLDPGFEEGRQYGRGKSGGQVRDEYREDFDEGRGGIGRAIQSERLRDYDEQGRFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L325</accession>
    <name>A0A367L325_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mis6 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_4840</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CENP-I/CTF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L325"/>
    <dbReference type="STRING" id="1330021.A0A367L325"/>
    <dbReference type="OrthoDB" id="6347512at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000939">
        <property type="term" value="C:inner kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034080">
        <property type="term" value="P:CENP-A containing chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22647">
        <property type="entry name" value="CTF3_NTD_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012485">
        <property type="entry name" value="CENP-I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48208">
        <property type="entry name" value="CENTROMERE PROTEIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48208:SF2">
        <property type="entry name" value="CENTROMERE PROTEIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07778">
        <property type="entry name" value="CENP-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI08824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="722" mass="79015" checksum="B0AAFA2E0A7DB8C3" modified="2018-11-07" version="1">MAPAADAAIELLTQDIIGASRIPPKSRSTSIKPTVARLASVAYENGLATETLVQLIDLVALPSLLDQASLATVARNLYPKGSVSRPVVLRVVCALGHGVQKPSLALQAILLKWLVMVFHLLEERAVLTRAYPVLFNLLDTAAIRTSDRSEYRLCRYFVSVSSPCLADVRDRLDLSRQTGNDPAIVGLLRVFKDYYPEIIVGEAVRGKASAFKHPDTHWRARLDEIQESSRSPAQGRFAGARHGFRVNKLVNRSYGLIPAVQTSEATEDSVTLEEIDSVEGFVQNLEKIELPNQLVAVLADPLLQKLLLLRPGPESQRRVTNWLTSVLRDFVEGDVDQESLWAVLAVLRDFVVQTRILPPVFLDYFPRFAEAWGGGCGYSDIVFDLLSHAPLHDFAELYTNVFQPLETAVLDDSPATQVALLTFYTNLLDGWITALRSSEVIPPDGSQIVAALVRHVSRLALTVLQTAPGLASESAILSFYEQTVRLVSDDVLKLHMRIELPPSVLVYKLFFSPSLAIVSRLCGILACYKKGFETAMSTKARHDGSSRVDALSYDRAYVNRYNGFLMDMCNCLWRARAFSDTDTNARGCMVPRPTVSALEAYVSSVDRGSSLATLLSISHAPVMCLVSIRRVRELEDAAPDGSLRTRHAGPVTQGSLTKLTAAGGVKLSWQEYRIDVLRSLSGQGLPGVTELLKNTMTVLKNSMEGGGAAASSQATPQATPTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L392</accession>
    <name>A0A367L392_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI08895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L392"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="110" mass="12969" checksum="463400A2416F1FA4" modified="2018-11-07" version="1">MKLKLIINWNTMTWLYVTPFRDLEEDFNVMDQPDDLTLRVDRCDDHLQRADRCDGCLVPRSIGCYNRYRYSAPIAVTIAVTSLIGTICSKWPYRLISYPFKMKKYALYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3C1</accession>
    <name>A0A367L3C1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">L249_5117</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the SWR1 chromatin-remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI08926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367L3C1"/>
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    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
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    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
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        <location>
            <begin position="344"/>
            <end position="418"/>
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    <sequence length="1705" mass="190810" checksum="D6E62D0CD934D921" modified="2018-11-07" version="1">MPETAPPRSRPAIADPTSPGAASEDLSPPPDSPHVSEHASDLGVDVPPRDGRVEPDAIPQTTNGREDSDLDDADAVDSRPLKRRRIGDPTSPVPAVRKSKQESPPWRRVEPEGPTSFTENGRRKSGRINNVVPREVQPRDKRRSTRRSLNTLAGPAPKKDELPIFSHGSKESTQPARRTAITPKAVITNPPPPLRTSSRSTRRPSPSPRPQATRYSTRRRRVSHLTDNADDTNSETPNEGSWQARHDEGTSLPRIKLRISNSGLIPLVHPDQVRKRPKLGSSFQDFWDRAGSIPVEQGGLQASEDGPAYTDEMALRDAQSILRIEEEAEPGGLLSEDRCSLFAPEAAQEPPKQWTRQDHMVKAMANFRKLLVAEQQRHRAAAKKLADACRDEWLRRQPKSAEEIEAEEQEKWITRYRLVVKAMLGTWENVRAHVNRQRLEQWEAEEQKRVKAALNQAVSLSEQKLQARRGRGDSEEEGFDDDLSDVNSVTGSDDRRLGKAGDGDDDGDVEDSDNMSTTDDEDDDDDDDGSLRHAADELLSQEQLRAKYAYLDDPRQSEDHDENAGFTSHDASSSKPDADLACDESDESVDMDDDLGDSDMDSEGGPEAVSDASDESGVETRGLLGLLFEKPELKHLKASASQATHVFDGHDGTTSGIDGTGYSKGDVSDASGLVDQTLEDDDDEMSLVRHPDSVFGDASEGEAGHAAGLGRSPAPGDTTTVDPYGPIESDQTDIGVVSTPEKSLVALDDAAMDPQAGAQVPFDRLAKPEGCLVISPETEAATNPASPRHSQSPRTSDTKPSELDAASTADAAPAKTGTRRSSSAQEYARHKTEIPFLLRGTLREYQHDGLDWLAGLYANNTNGILADEMGLGKTIQTIALLAHLACHHEVWGPHLVVVPTSVMLNWEMEFKKWCPGFKILAYYGSQEERKRKRQGWTNDDVWNVCVTSYQLVLQDQQVFRRRRWHFMVLDEAHNIKNFKSQRWQTLLGFNTHSRLLLTGTPLQNNLTELWSLLFFLMPAENGEGGFADLQEFHDWFRKPESQILESGRDQMDDEAKAIISKLHKVLRPYLLRRLKADVEKQMPAKYEHVEFCRLSKRQRELYDGFLSRSDTRETLASGNYLSIINCLMQLRKVCNHPDLFVDRPIMTSFRMSRSVAAGYEATERRVRHSLLPDDPMAAVSLVFLNLVPTEQENVSTAQAHEVTHLNSHSKLVELREAQRKRAQAGCTRLDPSTLWSCIDYLEGTARWDRFEELQHCVYLNALRRQQRPIFGKKLVDLVTVVGTNSGPCRPRPKVPQQVMAWFENDSTFVRSMVPTLDKRADRLKTTLEKFCCVTPAVVTRDLQPLLLGRRGVEALSEEDLRLSAPVRWAPFLPKVAPVDPWHEARMRLSIQFPDKRLLQYDCGKLQALDRLLRKLQAGGHRVLIFTQMTKVLDILEQFLNIHGHKYLRLDGATKVEQRQILTDRFNNDSRILCFILSTRSGGLGINLTGADTVIFYDQDWNPAMDKQCQDRCHRIGQTRDVHIYRLVSEHTIEANILRKASQKQMLDEVVIQEGEFTTDHFNRLSVRDVLGDETGSGVSAADAALDRVLGGPGEGRSVVSRALEQAEDREDVAAARVAEREIEADDADFTERPSGVSTTRQGTPSVKWMLDEQKVEEVAEEDAGVHSIDEYMVGLMAEQLKGTKLELPRDKKKGKKKKGKDTRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3G3</accession>
    <name>A0A367L3G3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_5132</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI08947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3G3"/>
    <dbReference type="STRING" id="1330021.A0A367L3G3"/>
    <dbReference type="OrthoDB" id="10251073at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10567">
        <property type="entry name" value="SWIB-MDM2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019835">
        <property type="entry name" value="SWIB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13844">
        <property type="entry name" value="SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00151">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEK-C" evidence="3">
        <location>
            <begin position="7"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="DM2" evidence="2">
        <location>
            <begin position="189"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI08947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="270" mass="29399" checksum="C40CFE7D73A3A04F" modified="2018-11-07" version="1">MSKSLTPEELDRFTSLIDDILANADLETISRKKVRQALETALGGRDLSAQKDAIKRLIEARFDAVSGADATTVDPSPDADGARTKRPATNGASENGDTDPSASPEPAKKKAKRSASSEDADARLAAQLQAQENSLARVRSTRGGGDRAKVTKKRKAPKKKSSKKVGDDDDSEVDGSGDSAVPKRKAGGGFQKPFTLSPMLSDICGETQLSRPQVVKKLWEHIKANELQDPKDKRQIRCDEKMHAVFKQSKVDMFRMNKEIGNHLYPVGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3K5</accession>
    <name>A0A367L3K5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CST complex subunit Ten1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5092</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI09009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3K5"/>
    <dbReference type="OrthoDB" id="5275361at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990879">
        <property type="term" value="C:CST complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016233">
        <property type="term" value="P:telomere capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024222">
        <property type="entry name" value="Ten1_fungal"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12658">
        <property type="entry name" value="Ten1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI09009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="118" mass="12824" checksum="A10A1626EFA6A55C" modified="2018-11-07" version="1">MSRGPVPSRLCLLSSLPDRPEGEKVRFLGCVTSYSVASASLVLCHLWPRDAKVTVSVDVQLVLQSLGEELTRVGEWINVIGYVRGTGGDSARVQALMLWSTGPLDIQRYETSFELGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3Q1</accession>
    <name>A0A367L3Q1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Heat shock factor-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_4829</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HSBP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3Q1"/>
    <dbReference type="STRING" id="1330021.A0A367L3Q1"/>
    <dbReference type="OrthoDB" id="4159489at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009643">
        <property type="entry name" value="HS1-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06825">
        <property type="entry name" value="HSBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI08832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="96" mass="10023" checksum="1865D2655CD9D1DD" modified="2018-11-07" version="1">MAPEESTETSKEASHRDADESVAKSTPPSTEPANADVSAAVEELLNSLSNKFSGISSEMFSMMDAMTRRLDRLEAALALGKDTPPKEGSGSSSSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3V1</accession>
    <name>A0A367L3V1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA repair protein Rad26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_5046</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI09101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3V1"/>
    <dbReference type="STRING" id="1330021.A0A367L3V1"/>
    <dbReference type="OrthoDB" id="5245063at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048379">
        <property type="entry name" value="Rad26-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022093">
        <property type="entry name" value="Rad26-like_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048380">
        <property type="entry name" value="Rad26-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21046">
        <property type="entry name" value="Rad26-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12331">
        <property type="entry name" value="Rad26-like_helical_rpts"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21048">
        <property type="entry name" value="Rad26-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad26-like N-terminal" evidence="5">
        <location>
            <begin position="360"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Rad26-like helical repeats" evidence="3">
        <location>
            <begin position="485"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="Rad26-like C-terminal" evidence="4">
        <location>
            <begin position="692"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="81"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="274"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI09101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="761" mass="83001" checksum="9C3895C6D5940024" modified="2018-11-07" version="1">MDLDDEFSDDGFADLTDHALQELERDAIRLTQAHGQRPSHPVGSDVRLSDYGWEEEDDDLDNAEVVNDVGLFIGRPVVDNSLQKPQNHHAPPLLQSQQPPQQSQQLPRRPLPQMPNPNWNPNIDPASRSVNRPVPSRPPADTPGPTQGSQPRNEVVSALQRRLRALEAELNAARGEASILRANSTKAQHEYHAQITSLKKLNAEQLAKQERAVEAAVAAEKSANTELQFLQRDMREVHDRVRRRDAAVTAAVTPSKASKSWNMADGFDRLDMITSPSKGQQRGRASVAANVGERTPTRGKRKRPVADSPVAALEFHSQDVAMVDEDEMGKEQQQQQQQQSAVPASRPLMCDAAPAAPFEFLQLVLDQGSFHHQPPTFDMLSRFSYPCDPTAASLASIIFEKLPLMGNPQRPMQLLVDFAEHVISLWARCVEEQYWDPVRYLVSLVSFTLDLHTVSVAPLIVASLAPVARATILVLAEGRRRLPEGSPVEEPVDTTQVLSLLYMSALACATTPSKTETGFEYTALGFWRLISLDMVLLLLTPKQKLDDTVGMLDLLATSSLPESIGPVSDEAEAVVVARAVVERVSAKLTEPSRRVRLAALRTLAAFARYPFGALQLASHDNALPRLVACLSAAIDALYDQPTPPSALPPMPDGLASQLHLPEPSAPAELCLIVSRSVLLLHALVTPDATAAADISQKLALAHGGSQRYLIALGRLFFVENLVIEAGIDSEAVEAARELLEMAVTPDEGETISEAFGAGYNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3X6</accession>
    <name>A0A367L3X6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA exonuclease 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_4924</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI08912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3X6"/>
    <dbReference type="STRING" id="1330021.A0A367L3X6"/>
    <dbReference type="OrthoDB" id="8191639at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06144">
        <property type="entry name" value="REX4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000007">
        <property type="entry name" value="Interferon-stimulated exonuclease gene 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037431">
        <property type="entry name" value="REX4_DEDDh_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF45">
        <property type="entry name" value="RNA EXONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exonuclease" evidence="11">
        <location>
            <begin position="136"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="298"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="313"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI08912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="325" mass="35883" checksum="94464F8AF5BC4777" modified="2018-11-07" version="1">MAELSSNWKKLQARLQAEEAPQPPCKRKADGSSTHHRPARRPKATVEPVTSSRKQDIYKRHTSRARRPEMGGVQSSVTESEPGDGSSPSLALWAQGSDISAETLAEAYGLGLKGDFIAMDGDRINHGLSANIEPGKFVALDCEMVGIGSGGYKSALARASLVDFHGRQIYDSFVKPKEKVTNWRTEYSGITSKDMKLARDFDQVQAQVSRLLKDRILVGHDLRHDLAALKLSHPRRDIRDTANYPGFKKLTNGQTPSLRLLAKELLGVRIHDEAHSSIEDARVTMLLFRKNKSGIDGDHAGRFASKHAATTRQKGKRKIKARTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4E1</accession>
    <name>A0A367L4E1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_1492</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4E1"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI09278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="132" mass="14809" checksum="7FFFC11B5D8E7958" modified="2018-11-07" version="1">MEGETRREDEKLTRSAATDELFAGGTRYGFVTAQTQMRNGGPSFRAARRKVARRQHVVVAVALWQHPPYHISDRLATPPFPFPSLPTMPIDAVTETGKKGADDLSVPRAHYCILTHSRPRLKTSRAIFLPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4Q7</accession>
    <name>A0A367L4Q7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">acetyl-CoA C-acetyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_3676</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.9" evidence="5"/>
    <dbReference type="EMBL" id="LKCN02000015">
        <property type="protein sequence ID" value="RCI09416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4Q7"/>
    <dbReference type="STRING" id="1330021.A0A367L4Q7"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003985">
        <property type="term" value="F:acetyl-CoA C-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000007">
        <property type="entry name" value="acetyl-CoA acetyltransferase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919:SF156">
        <property type="entry name" value="ACETYL-COA ACETYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18919">
        <property type="entry name" value="ACETYL-COA C-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0630">Potassium</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="12">
        <location>
            <begin position="34"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="13">
        <location>
            <begin position="302"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI09416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1007" mass="109956" checksum="0F9A7E159AEA0682" modified="2018-11-07" version="1">MAATAQLRSVGRLARHARQFSTGAARRREVQDAYILSAARTPTTKFNGSFLSVPAPALGASAIKSAVAKSKVPVDLISDVYMGNVMQASVGQSPARQAAILGGLPETIDATTINKVCASGLKAVSCAAQNIQLGLAEAQVAGGMENMSRVPYYMPRASGLPAFGSVMLEDGLIKDGLTDVYNKFHMGNCAEKAVKQHSLTRQQQDEYAMQSYKRAQKAWQDKAFADEIVPVVVTGRKGSTTIEVDEGFADVKFEKVPTLKPAFVTDGTGTVTAANSSTLNDGASALVLGSKSVARRYGSGSRVLAKLCSYADAAVAPVDFPVAPAKAVPIALERAGITKDQVSVWEFNEAFAAVILANQKILGLEGANVNPLGGAISLGHALGSSGSRILTTLLHQLKPGEYGVAAICNGGGAATAMVVQRVETTDGRARKNLMPTPTSSSSYLPTWALTITTTTTTNSRTAHDDSQPSHPFTMSLVRQFLLHVRKHVRDQRDDSLRVWLTVDPVTPQPYHEMAAELRRDFSQPACMEAVISDCLPQEDEYDMPEGQAAVWPSFQAFVREYLTFWRDVNHDDLLGAHELLTILVNSCGTAFAHPQHGALLIHLSISLCETLARLTLQLSRRPEVARRARSRDEEGTSKTIAESSAETIQKIFKTCLMDRSSGRKPEGKKIGVYRFANLVTKLLFACRRTNLATMIFRNISASSPPLHLYPASQRVTYLYYLGRFNLSTSHYLRAALCLEQAYLQTPPQLVSHRANILTYLIPCNILIGRFPSALLLERPEAETLRPIFLPICEAVRSGNFINFQAHLATHEAWLFDKGLYLPLCHRLRPLLWRSLARKTFLLTYVPPSDADGPRKAATLDLADLHTVATYVQRRLEGWLPSSQIVRSRPPAHVNALFIKAVTSNVHFPDETTLVPPPGGSKRLHPNEGLIWGNATVQYKHVEMVVANLIEQELMHGFIAHSLGRFAIIGARAKGPVPAGWPVVSQAISERRFDEKFDPYEVPGLVMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5U0</accession>
    <name>A0A367L5U0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SUR7 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5U0"/>
    <dbReference type="OrthoDB" id="4159154at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052413">
        <property type="entry name" value="SUR7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019:SF7">
        <property type="entry name" value="SUR7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="34677" checksum="86D03633F808CA99" modified="2018-11-07" version="1">MATTSRFLVLLPVVLALVSFVLSSLTLFAGHKQGFMEDYAVIRINTSHIGHNLFDKRDDDNNNNNGQPALLTDLQGWINDKKGDIRGTIRGKLNEGAGRLVDKVIGKLHLAQWYSMHIMDACEGTFEPNFTSPDAKLKTTKCTTSDPTHRLNLTHLVDSQLNLGPLNLSLSDFSWPDSVQDKIDGLNDALTGLFVVYVLAMGCSGLSMLASLGAFFLPDLSILTLVNLVIGSIGAMSCLIGSVIVTATASKAVRHINDRGARFGISASRGIKFYTVGWIATGFMLTVAAYWLGQFFIVRHAKAADGLREKQQMQEEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5U6</accession>
    <name>A0A367L5U6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_4036</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5U6"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI09794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="60" mass="6812" checksum="4C066987B830C9AC" modified="2018-11-07" version="1" fragment="single">MKPIADLFRCLYDRRPPHCTIHRLATVICSPKGRVATSSLVGLCANGQEYRIGRDWRGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6C6</accession>
    <name>A0A367L6C6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cell cycle control protein cwf14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_8490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BUD31 (G10) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI09986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6C6"/>
    <dbReference type="STRING" id="1330021.A0A367L6C6"/>
    <dbReference type="OrthoDB" id="277109at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001748">
        <property type="entry name" value="BUD31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411:SF0">
        <property type="entry name" value="PROTEIN BUD31 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411">
        <property type="entry name" value="PROTEIN BUD31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01125">
        <property type="entry name" value="BUD31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00322">
        <property type="entry name" value="G10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI09986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="12974" checksum="4741715AA4DBD2E6" modified="2018-11-07" version="1">MPAIRHASKRKPPPEGFGDIEDDLLIFANKMKDAHNKPPPPGPKHQAQWEVFQISHQRSRYIYDLYYEKEAISKELYDWLLKNGYADAMLIAKWKKQGYEKASLASAAFPGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6M0</accession>
    <name>A0A367L6M0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Exocyst complex component Sec3 PIP2-binding N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_8541</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367L6M0"/>
    <dbReference type="OrthoDB" id="27109at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13315">
        <property type="entry name" value="PH_Sec3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.90:FF:000003">
        <property type="entry name" value="Exocyst complex component Sec3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028258">
        <property type="entry name" value="Sec3-PIP2_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048628">
        <property type="entry name" value="Sec3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019160">
        <property type="entry name" value="Sec3_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092:SF14">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 1 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16092">
        <property type="entry name" value="SEC3/SYNTAXIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15277">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20654">
        <property type="entry name" value="Sec3_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09763">
        <property type="entry name" value="Sec3_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01313">
        <property type="entry name" value="Sec3-PIP2_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec3 PIP2-binding N-terminal" evidence="6">
        <location>
            <begin position="68"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="188"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="402"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="474"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1378"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1482"/>
            <end position="1584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1712"/>
            <end position="1799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="198"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="324"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="421"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="513"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="543"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="556"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1379"/>
            <end position="1389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1390"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1483"/>
            <end position="1504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1514"/>
            <end position="1529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1756"/>
            <end position="1767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1790"/>
            <end position="1799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI10075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1799" mass="200735" checksum="46113FA646E81A55" modified="2018-11-07" version="1">MDRGAGVTSAAASRAERFEDEKRRIIESCFSKREPDGSLIETYITHIRITEYSQHPSSPPPPEARTAESEKPRIIIVAVRRSGRVRMHKSKENTSGTFSIGKTWNLDDLSQIESFTGPQVGLSYREWAGDTGFIVTLGKQYFWQAQTDKEKKFFVASLIKIFGKYTGGKVPELTGFDPRELDQVLGAGRRPTASSARSPGVESVASSVASPSTLVPTPSSGTPEPSRLQKSSASRPLLNGTGSPAPSSDSVSSKDRVAATRWAAQTDKSQDAEAYSMAHRRDDASHTSRSRNGIYGVGASARYGESRESSEQPQDVPARPPSAHPDERPPPERRRPPMDPSRPQDRDLVPPPLVSSNVTREPIPPPPKSTKRLFNGDGIGLGWPLHASRDQDAAKRVVKTLNTNLREVSPKSDPIRGAKGASTSSATEALSPTELSLSPDPPDQDESRPGLGPMIKAKRSKGDIAGALWKAASAATAFRPRPGGAGDRLRQTQSKADGPDGITSVVPAPSRPVSRDPRSESTDALKPTDRRDSNDVKADIPTANISRAASAQPSPSEEKSKQVKKEVQKEEQAARSVVAGNDVKYLQSLGIDPSILDGRSEEFGKWLDHFGWVPGQQMRTQTMDDIKTDIERELNKAQAGGWLARFQEEDERVDAIKRGIDLAISECDEMDNLLTLYAVELSTLSEDISYIEAQGQGLQVQTANQKLLRRELESLLETCAITSNDLEALRIAPLEKTRGLEDVESSLVTLFRAMTKMDPTLGGHEVVQTAAEAKGGGDSDPALGLNSDYGNMRIVQEKKQMYMQESAYFMRRLIEFMARQFDEAFSETQRCLDGATSNASSYDAGRDLLWRYSPLMLYARDVDLDNWNRLLQIYQDKSHPLYMGQIQNVVAVLRRNARKLTGDEADLLFSSQLEKHQEGGVATTARKLTVKRSQTLARALRSPLDGRTASTTTVDKANREGGCHAYEVFSSVLDEVLPLVEMEQNFIIDFFHATTLEQVDFPDAVAACLPRDRRGGDLRRHRLMEPDRDLARRVTRSMEVIFAFLESELQRLMDWVLGQDALQGVGVLAVLEKKLLEMSRSNQDYVNTLLQKLHGVLESRFRKFVDEQIRAIEETKVKVNKRKGVISFIRVFPAFATAIESMMTRQEANMALRRTVDREYERILKSMFDSLMVIAREHPTVTVTSGGADAEDKEALNFHILLIENMNHFMEETETRGLELLEEWKEQAKSTYHEHMGLYVNAVMRRPLGKLLDQLENIEAQLQMGKLGEAIARQPSNSSATFNKMLGSYEAKEVRKGIEALRKRVEKHFGDADDPGLSRGLVLKVTRECEVFYGQVESRIGRVTTEVYGGEVPYEWPRAETPLRLRQQTLTQIDFVSSFEEDEDDEEADDDRHGGPEGEGDEWREKNKQKRRSLSTKQKSDYDDDGKEDQRRKKRKTQEEGTTRRRYTVGEGQGESNQRNHQHLHTQTLTQLLGVDAAFVADSDADSDGDGEEQPQEEEEEEEVVVVKKKESDLVEIPDSDDDDDDDDEGSVHHNDDDDDSNKVEQQNNNDDDATQPPKPHRLPLESQRVPAPILRSMPPPTPRTDILLPFQTAPLISGRTKHIDPKGTTMTSTNLVVRIWFLDGGVLRHMACVDQALSDDDEGKGQDQLHGKRRQILRIRQMYELNDAVSELDMRREAWIPPGPMLRHHYLPPAVVGQLLWNLRQALFDDDDDDDDDFTPSSPIINGPPMPSSSSIAFLDHGASHVSLSPEPDATTNNNNKTPLLTRSQMLPESLLHDHGPSPPRLEICDSEDDDDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6S5</accession>
    <name>A0A367L6S5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_8454</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6S5"/>
    <dbReference type="STRING" id="1330021.A0A367L6S5"/>
    <dbReference type="OrthoDB" id="5325318at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050085">
        <property type="term" value="F:mannitol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019594">
        <property type="term" value="P:mannitol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000090">
        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF103">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="46"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI10108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="347" mass="36369" checksum="B4A5233ECBBB045F" modified="2018-11-07" version="1">MFFAARNAVRLAALARPSPVFFVAATRRQLTKTATKGAAVKFYGGENGDSHAASPAPPSSNASSPGSAEAHHPPPVQPLKASVHAALPPTMKSLSLFGKTVIVTGGARGLGNQMARACAEAGAKAVVIFDANAQLGEQAAAELHGQSGVPVAYCTVDVRQAEAIDVAVSDVVDRWGVPDVLVNAAGIADSNIKAEMYDPQMFRRLIDINLTGTFLMSTSVARHMIAAEKPGSIILVASMSGSIVNYPQEQSCYNASKAGVIQFGKSIAAEWAKHKIRVNCISPGYMDTALNRVAALEAQKKVWTSLTPQNRLGGVHELNGLCVYLASDASAFMTGSNLLIDGGYSCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7F5</accession>
    <name>A0A367L7F5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Kelch repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_4374</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7F5"/>
    <dbReference type="STRING" id="1330021.A0A367L7F5"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23244:SF471">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23244">
        <property type="entry name" value="KELCH REPEAT DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="534"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="582"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="655"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="692"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="589"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="749"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI10356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="761" mass="81934" checksum="EC7E200D85281122" modified="2018-11-07" version="1">MRPHGFLFMGFVAAQFSNWLHHQVNTSICYWKQPRAAIIRDTVYLDGGEIWWTPGLDTGELAAPSNQGSFASTLSSPVRVTDEEETGNFQGIVLTYNLTEPFNPSSNITGLLLKRQLVKANGISSSPNAYDGAMLANDNEFFLYGGTMLRNDDLYRQPAADAVLEYQAFKSGVDKPLLREGFREAILDEGVTRYLAFGASASAPSENKAWHFSGLASPSKGPIFSNPSVNGSTRAMNVSETLITLDMSVELSEKWTNATLPSSVKGRSNAEMVWVPVGKQGILVVLGGVVYPEWASVIHQSEDGAASMRESPSFMSLIDIYDVAADRWYKQPTTGGPGTRTRGCAVVAPAADRSSFNIYYYGGFDGIHPLNPFYDDVWVLSLPSFTWTLLNEGTAIHARAGHRCFLPYPDQMMVFGGYAAEPGDLPSCLDKGPVVVFNITSGEWMDSYDPMKHGDYGVHEKVRASIGGSANGGATAMAPVPSGWSSPDLAHVFGEKYDTRKIKKYWPYRTTALAGRVELPAAQEENNGSDHKRVIIPAVLVPLVFLAGLGIIARRCWNRRRRSRAGSSADSEAAMRIRSWVRGQAAGKSSTATSSSAVSPEPDMVSATPLSRDGGVRPSAHHEMADTQLAELADTSPPVELYDTGLTPIDVIQKHTSLGPSNRPRPPSDPSHSSICDNSSFVSQTSGAAYMDSPILGGGSSSPLEGCGRPKAGSDSRRAGALPSMTEESLSPLEAGESPIIPPVAKRSVFRENVGDDGSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7F7</accession>
    <name>A0A367L7F7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL23m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_4375</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7F7"/>
    <dbReference type="STRING" id="1330021.A0A367L7F7"/>
    <dbReference type="OrthoDB" id="275582at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_uL23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL23M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12059">
        <property type="entry name" value="RIBOSOMAL PROTEIN L23-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="203"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI10355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="236" mass="26519" checksum="2DD62A0A7639C748" modified="2018-11-07" version="1">MAVRAPAFRLGKKQIYLPTHVITMLRRDNSPLNEACFRVPLTFTKFDLRDYLWNLYGVEVRSVSSVVAQQGLQRRSRMSSSVYRPLSRKYMTVVLTKPFQWPDPPSNLEPWYNDMWKKREEAEEKRRTATEESNGYKKMSLISKQPWSESRKQLASLAKRMLDGKEEWSNDVELDPRWDKLLAKDTKAAAAAATAAATAAAAAAAAPTTAAAAASAEAATTASEDDDKNSNDELRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7K3</accession>
    <name>A0A367L7K3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein HGH1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_4394</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HGH1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7K3"/>
    <dbReference type="STRING" id="1330021.A0A367L7K3"/>
    <dbReference type="OrthoDB" id="338814at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039717">
        <property type="entry name" value="Hgh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007206">
        <property type="entry name" value="Protein_HGH1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007205">
        <property type="entry name" value="Protein_HGH1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387:SF9">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04063">
        <property type="entry name" value="DUF383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04064">
        <property type="entry name" value="DUF384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein HGH1 N-terminal" evidence="3">
        <location>
            <begin position="118"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Protein HGH1 C-terminal" evidence="4">
        <location>
            <begin position="308"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI10399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="380" mass="43016" checksum="2BAF2C9ABBCB7F6E" modified="2018-11-07" version="1">MKNLFAFFRLGFNISIPSFLPQGCRQSWKRHLVGFIAHPNPQIRLAATEALVPYSTAETAVFKADDLKPVRNLKLLVRDQPKIAEHVLDILVNLSADAVVLDHLAGDQRLLELLFLRLVDKQEPNANLISMLLANLAKSQGFEAAILRAKQPSPPDLGADDVVLNQLLDLFVKGHDGRYNKAANYDYLAYLFADLAKNADVRRYFVEPQRYDDVIPLTKIKVFTEHTSTVRRKGVASTIKNVAFDVQSHPSFLSETGINILPYVLLPIAGADEYDADDMMEMLPDLQLLPPDKTRDTDSSIVQTHVETLTLLTTTRQGRDLMRRVKVYPVVRETHLRVDDEGVREACERLVQVLMRDEEPEVNERVQEVQDDEDDEIIPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7Y2</accession>
    <name>A0A367L7Y2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_4351</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7Y2"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI10525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="69" mass="7940" checksum="B7C13A6934F35E8D" modified="2018-11-07" version="1">MDDCMHLVMGMTYPDVDDDHATEFRGLSLPLLRRGRTSVRGDFASHAAQPRQPMAMTRDSNTNKMEFFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L928</accession>
    <name>A0A367L928_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mis12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_5332</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mis12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L928"/>
    <dbReference type="STRING" id="1330021.A0A367L928"/>
    <dbReference type="OrthoDB" id="1884855at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008685">
        <property type="entry name" value="Centromere_Mis12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14527">
        <property type="entry name" value="PROTEIN MIS12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14527:SF2">
        <property type="entry name" value="PROTEIN MIS12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05859">
        <property type="entry name" value="Mis12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="117"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="201"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="291"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="381"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="163"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="388"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI10916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="411" mass="44733" checksum="7AB7F0C7A37DC8C5" modified="2018-11-07" version="1">MSVPETDHELLTEHFTYPPVALLDDIINTVNILADRALDSVERLLLSIPHQKLGFATATAARQEIESGTHQLETLVNASIDKNFDLFELYTVRNILTVSPRDAPFVRLAHYQGLDFESSSSSSSSSSTSSSSSAAAAAAATAEDEGEGEKKGNGHVVPSLESVTALRRRLQASQRLNALLEKERLQNDALLRRMYALLGEKQPAHQEGSSESESEEARQHEDTTSTEQAKAGDEAITFSHLLKTHPLTDGGSDNPLSTTTEFALSQLPTLRTLSTTLQRLVPDLGVAVENDGQQQQKDGAANPSSLPQSQQDHHASWRSQRTEYVEASSRKCIERVGGGGHQDDDDDDYDSHHPQANKRPRLASARDVETLESIAAALARGEEAVKAEEEEEEEEEDGEGKDAAEAMDTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L966</accession>
    <name>A0A367L966_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_5293</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L966"/>
    <dbReference type="STRING" id="1330021.A0A367L966"/>
    <dbReference type="OrthoDB" id="422427at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051711">
        <property type="entry name" value="Stress_Response_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540:SF1">
        <property type="entry name" value="ACTIVATOR OF STRESS GENES 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47540">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="56"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="204"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="684"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="725"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="763"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="864"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="934"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="146"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="696"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="764"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="775"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="864"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="939"/>
            <end position="949"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI10970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="996" mass="112044" checksum="3BBE676C96263289" modified="2018-11-07" version="1">MSGDLSDDDAVGDWQIHHVSSPADSAKSDAELDDKAANDPSAPSQPIQKRRRVTRACDECRRKKIKCDGKQPCTHCSVYSYECTYDKPSNRRRNPAPQYIEALENRLQRAEGLLRKYMPDVDLADPSLDPAIQQEFQNRQRARAKQHQDPTEEPASHGDAKLMTMIDSIGQLDLDDKGGWDFHGTSSGAVFLRRMKDHLRGMMGPASKAPFLPRPERPPGLMALESPSPRGDSPLSTASPLPELPSKHVARKLCHYSLSCATCLVRIVHVPSFYERFERVYDQPVESLDQEDTRFLGLVYAVLALGCMYSSLDDVKPESGAYKAAIDQGIKYYKMARALLQDLAECRDIPSLQALLYMILFLQATSNLSACYSFIGVALRSALRIGLHRHLQHDKIGIVEQQVRRRVFYVIRQLDIYVSTMLGFPLLLNMEDVDQLYPIEVDDEYVLDTGIMSPPVGTPSFFEAFNAQTRLMEVLGKITKYVYPMHGQDQPTAKGPPTYLVSYARIKEIETELQAWYERLPETWRPSPDGPIEVVRVRHLLRFAYAHVQLVLYRPFLHYISPRLSQASEVDELSYACAAAAISVSRNIVHIGLEIRKQGVLSGPYWFMLYTEFFAVLSLVFYALENPDKPGSQEVLADAWAGRQMIADLADKSMSADRVTNALKPLFDQLPESLDQALARPLPSRKRSAGLGKAESSLQTLASPSPSTQRIGDFARAGASTLHRAPLASPTPMDGSGQPMDPAFPQDLSFAAGVQDMIPMDLSSRATPESSSTGSSQRQRLWSQQLQQGTQDSVNKLDSLMFPSDDPFAYPNQLMVDLGYQPKTVEPSTAMTVPDGDAGTFFMSPLDELGDGMVGHTSPYLVQQPEQEQQQQQQQHEQQLFGLSGNPYDPHDIMAMHTAQHQQYQQQQQQLRQYQQQQQRQLQQQQQQQQQQQQQQQQVPRSSTQQQGHRSIFSSFRRARSDRQQARQIEQMFTQQGMQPDWGSFFGSGRGGFQGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L967</accession>
    <name>A0A367L967_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_5296</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L967"/>
    <dbReference type="STRING" id="1330021.A0A367L967"/>
    <dbReference type="OrthoDB" id="2563500at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
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    </dbReference>
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        <property type="entry name" value="TF_fung"/>
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        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF7">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="2"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="54"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI10967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="579" mass="63807" checksum="7E8895A4D59B60C9" modified="2018-11-07" version="1">MGCRVCRARKVKCDGRPNGCRNCQRLQLDCDEGGGGGGGGSNSAPVPKMRTYRSCQSCRLSKTKCSGSRPRCGRCVAKAIECLYDGDSVPRWTTSLRRTVVDLKDAVTVEEEGEGEEAGPLSWLLSSELPTGPKLRRLVEQYFANVHPLRCFAFVHKPSFMHQLDKGGVGSEDESCSSSALLHIMCAHGARFLLVGHCLDGDVATPPPPTLVSSAGSQWARRAESLVLADLGTISIQRLMVAILLHDFHLRAGEYGQALMLSGLAVRMAHALKMDGEYDADVLCSSEPGPGAPSVASRESRRRLMWACYVLDAGSGADLLRESDIKIQLPSNERNFGLRIPAVTETLAVGHVLQLLAPAVVPRRPAANMGIMAYYIRLVALWKRIVRCGRQGPPPPPPPWQPDSPLAALEADLVQWRRDLPDFVEYCPETIYARLDSNQFGALLLIHCTYHHSHLELYKVAMADLFRLAEPAAEEQRQALQAAQAGCYHHARRISDMLAEAAEHGVRFLSDSQLPFYLYHSSRVMLYYVARLLDPRRPGAEAKMKDAVEAVERNGRVLRLMGILFPIARTLVSFCVWKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBD9</accession>
    <name>A0A367LBD9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7432</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBD9"/>
    <dbReference type="OrthoDB" id="4960422at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI11721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="86" mass="9926" checksum="0EC22EE13CADEB79" modified="2018-11-07" version="1">MPYILLPSIAEPNALASAKIAPRAKEGYLIGIEGLYRHIYKVFLLDEDKIFYNLANLNLDRSITHIANVSKDNNPFNPNDFFYYYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
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    <name>A0A367LBY0_9HYPO</name>
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        <recommendedName>
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        </recommendedName>
    </protein>
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        <name evidence="5" type="ORF">L249_4212</name>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
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            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
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                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
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            </authorList>
            <dbReference type="PubMed" id="26511477"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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        <property type="entry name" value="6Pfruct_kin"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </evidence>
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        <source>
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    </evidence>
    <sequence length="666" mass="75082" checksum="56FB6E97FF511003" modified="2018-11-07" version="1">MPSAVVIPRPGVGHKQAKQSVLAQAIMQNSLTSPSALPSTSEPDRHLAVLPPFASRHDLFPASSPSLAPSQTVRTIRDLTDTPPLSHSVSSTAPNSPRMPPQRRNSGSQTPRVRPHATTLNIPGMTRSRVSPDGRIPQRDVAAKLVIVMVGLPARGKSYITKKLQRYLSWQQHDSRIFNVGNRRRNAAGVKVAAKERLAPEPYCLDPPVRAATILLQGSPVADATLDPDSAEPTVLSLDGAEAHDELDQSASFFDPRNERAAAMRDQVAMETLDELLDYMLNQGGAVGILDATNSTIRRRQQIVDRIRRREPKLGILFIESICRDQHLLEANMRLKLSGPDYRDKDPHKSLADFKNRVAAYASAYEPLGEYEEDNDMQYIQLVDVGRKLVQHRLKGFLSGGISTYLSSFNLAPRQIWMTRHGQSIDNELGKLGGNSALTERGHCYGQALYRFVTHKREQWLMEQKSKIAQASFPPHPGDNTPPYPDMNQDLDEKNFCVWTSMLRRSVETAEYFDADDDYDVKNWEMLNELNAGEFEGMTYKEIANRYPEEFHRRSEDKLNYIYPGVGGEGYLQVISRLRDMVREIERITDHVLIIGHRSVCRVLMAYFMDLTREDITDVDVPLGMLYSIEPKPYGIAFHAYKYDEAQGWFEELPNYKPQKAARGSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCH9</accession>
    <name>A0A367LCH9_9HYPO</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">L249_0573</name>
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    <organism evidence="4 5">
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            <taxon>Sordariomycetes</taxon>
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            <taxon>Hypocreales</taxon>
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    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
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                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
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            </authorList>
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        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
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    </dbReference>
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    </dbReference>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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            <end position="20"/>
        </location>
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    <feature type="chain" id="PRO_5016704816" evidence="3">
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        </source>
    </evidence>
    <sequence length="2129" mass="220656" checksum="46EB9B1D5A7B559E" modified="2018-11-07" version="1">MRRLLVLGLATAGQSRLVEATTQADTATAPSSYLADKSAFPLSTSSQAARLVPTSDCQDAVEKRFPSRDEQTKLCHQLLTKGVFGGTDSDANEANTFITRCDRIKLAHVCRSLESSNEIETASSSHCLDRLEHGLAQDAGSTWEFCRKHVLDADFLHNVDSLDARSRALFDDCFQSQSEVTRACESIEAPDASLQRPACNSVDNYEHVVRVYGASLQAACRNQASASTDNEMRALQVKTNNNGLSALKSTCECHSLYESIHSGEEPLASSSHPSSLSTNPTPLVKPTSQIKLALERRHLHPRGAEVKSQKTAFVADPNSGPYSTQTTHTLTRDTQLTQADVNSLLKRSEQFKFEVRNGLCAIHSMPDDARHVSWRLVYDLDVNLESKHGFRFEICDPSEHGRVVTKIQGQYVYGYALEVNGGASVAGSVRPDGTNELLCDTGNLTYITVHNKGIIGVRLAGEVIIENKGGIVFKCENINSCQQSRCHAEECHSNLIASVTPEELASLEDELPSDEELEHYEDEFDPDHKNRPGSGHNKTHHHPGSGSHQHNPRPHPGESHPGHETGSHKHNSTKPHPGHGVPRPGTEPQEEPEPDFGPDFGPDFGPDTFFPGYETGPEFGPEYEPGMGPGYGMGPGSSDTRPGNPGPDYSMEHPGHGPSSGENPGYDPSNEPGMGPGYGMGPGSSDDRPDRPGSRPDYDPSNEPGMGPGYGMGPGSSDNRPDRPGSEHGPGPDYDGSGPHSGPEYGDPDRNPDYDNGHNGPDYGNNPDYGNGPSYSGPDTGPNPDYGNDPDKNPDYGNGPGYGGPGEDPDYGNGPNGPDYGNDPDKNPDYGNGPDYGNGPSYGGPDNSPDYDNDHNGPDYGNDPDKNPDYGNGPDYGNNPDKNPDYGNGPDYGNNPDKNPDYGNGPDKNPDYNNGPDYGNGPDYGNGPDYGSGPSYGGPDNGPDYGNGPGRNPDYNNATAIAVLSIVLTMVLITAMAVNPDYGNSPDYGNGPSYGGPDNRPDYGNGPDKNPDYGNGPDYSNYPSYGGPDRSPDYGTSYNNDPDYNASGNNPDYGTSPSYGPDYSSPGNGPDDGSRPDYGPGYGNGHNSGPDYGTGPATNPGYGTGPDYGNGPDYGNNPSTGPDYGNGPDYGNGPGYGNGPDYSNGPGYDNNPSTGPDYSNNPSTGPDYGSNPSNGPDYSNGPDYGNNPSTGPDYGNGPDYGNGPGYGNGPDYSNGPGYGNNPTPAPVLTTVLVLTTVTALMVTTVLVRAQTTALARIRAMALVMSPATFPALTQALVPTLVPELAPYLLPALALALVSAAGTVRVLEAPAQDTAQIQAMFPALAPTLDHPFPTQALEVAQVGGIILALETLAQVTVLTLATLPAPAQVMVLAILLVLARALVLTTAPGLTILRALALDIIPVLAPAVLPAPVLAKVLATFLAMVPATLPEKVPATARVTAQATLLATALITFLAMAPATLPEKVPATAPVTAQSILLVTAMAMAPAILPEKVLATALVLDIMALEMVLVGGTLRAPEALAPATAPAQALAMLLAMALATFLAMGPAILLATVLVMAPVTAQATHLAIALAMLLAMVPATVLAMVPAIILPAMALATALATFLAMAPATLPAMVLATVLALVPATLPEKVPAQATLLATAPATLLERVRAIHLAITLATVLALAPATVPATALVLVKEILRAPDLLVQDMAPVPAPATVLDMTPVMALARVRLLAAIPAMVPAQALANIPAPFLALVLALANIPAPFLALVLVEEILRAPGLPVLDMTPVMALARVRHLAAIPAMVPAQAPATIPAPFLAPFLVEEILRAPGLPVQDTVPIPAPATVLELAPATVLGLVLELAPAMVPILAPATVLAPAPGNAPGDGTGYGPGTDPGYGPGTGPGHGTSTPGGSQPGTSTGPGPVPGSGVTPPGYGHGPNCHNKTGTGSPHSHGSPQGPGYGSPQDSGYGSPHGPGYGSPQNPGYGSPQGPGYDSPQGPGYGSPQGPGYGSPHGPGYGSPHGPGHSPPGSPTAINVPSSRPKPSQQGKAKPPAHKPGHGVVNYVFEKCKPGTQCHCVRTCTGGNCMVQHAIPGAAPPPLTFNQMGHLTIKGVSHAIQEAQKTKGHYGASPSSPQVGGGRSSSPRQKINIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCM6</accession>
    <name>A0A367LCM6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCM6"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="96" mass="10885" checksum="1CE8A70A5A849C16" modified="2018-11-07" version="1">MDEAATRKKERKAAAAGEYITEPRTYIHMYYLRPYVQTPIGTRRRRRRRRGGGVVCVSEGRVDKRGGKEAGGGCESDQQKRSKSKKRKSQPGSPCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCT8</accession>
    <name>A0A367LCT8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP synthase subunit beta, mitochondrial</fullName>
            <ecNumber evidence="3">7.1.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">ATP synthase F1 sector subunit beta</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">F-ATPase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">L249_0023</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCT8"/>
    <dbReference type="STRING" id="1330021.A0A367LCT8"/>
    <dbReference type="OrthoDB" id="14523at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18110">
        <property type="entry name" value="ATP-synt_F1_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18115">
        <property type="entry name" value="ATP-synt_F1_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01133">
        <property type="entry name" value="F1-ATPase_beta_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000001">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000004">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050053">
        <property type="entry name" value="ATPase_alpha/beta_chains"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184">
        <property type="entry name" value="ATP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184:SF71">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039072">
        <property type="entry name" value="ATPase_subunit_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0139">CF(1)</keyword>
    <keyword evidence="7" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-1278">Translocase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="167"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RCI12227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="517" mass="56043" checksum="352C4D3839968E6E" modified="2018-11-07" version="1">MLKRTRHQAYFLPNSSQQQSIRIVYECRGWQNSSGKNPMELKFDTAKLPPILNSLETQNNGQKLVLEVSQHLGENVVRCIAMDGTEGLVRGAKATDTGAPITIPVGPATLGRIMNVTGDPIDERGPIKTDKFLPIHAEPPPFIDQSTSAEILVTGIKVVDLLAPYARGGKIGLFGGAGVGKTVFIQELINNIAKAHGGYSVFTGVGERTREGNDLYHEMQETSVIQLDGDSKVALVFGQMNEPPGARARVALTGLTVAEYFRDQEGQDGEIISIPSIFQFAVSDYRAVLLFIDNIFRFTQAGSEVSALLGRIPSAVGYQPTLAVDMGGMQERITTTKKGSITSVQAVYVPADDLTDPAPATTFAHLDATTVLSRGISELGIYPAVDPLDSTSRMLDPRVVGQEHYNTATRVQQILQEYKGLQDIIAILGMDELSEADKLTVERARKIQRFLSQPFTVAQVFTGIEGKLVDLKDTIASFKAILNGEGDNLPEGAFYMVGDFASAKAKGEKILAELEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCZ7</accession>
    <name>A0A367LCZ7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GIT Spa2 homology (SHD) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_1315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCZ7"/>
    <dbReference type="STRING" id="1330021.A0A367LCZ7"/>
    <dbReference type="OrthoDB" id="5588096at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005826">
        <property type="term" value="C:actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902716">
        <property type="term" value="C:cell cortex of growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005078">
        <property type="term" value="F:MAP-kinase scaffold activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013724">
        <property type="entry name" value="GIT_SHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039892">
        <property type="entry name" value="Spa2/Sph1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056439">
        <property type="entry name" value="VBS_C3G9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21601:SF0">
        <property type="entry name" value="PROTEIN SPA2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21601">
        <property type="entry name" value="SPA2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08518">
        <property type="entry name" value="GIT_SHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23742">
        <property type="entry name" value="VBS_C3G9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00555">
        <property type="entry name" value="GIT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GIT Spa2 homology (SHD)" evidence="2">
        <location>
            <begin position="132"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="GIT Spa2 homology (SHD)" evidence="2">
        <location>
            <begin position="189"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="713"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="735"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI12308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="783" mass="86215" checksum="93B239F9B4A5B0E1" modified="2018-11-07" version="1">MSVGGRNAPLSPISVGGSEWSFSSTKARPPEGGGPYPINRGNLVSPPQSGGSNGAMSINGFPSGPRSNGGPSPPPSIGRSSNGTNLFSSRSEGNRNSARTDIDESLLQEHYLALKAFLNTRDANNRQQPNKARDKLLRLSSVQFHELSTDVYDELMRRQATARAPPNAPNGPPSFLLPEKTFHPKRNQARQRLSSLGPPRFRDLAGDVFHELERRFPHFVGGDIPRMGSAASMRPGPMSRMGTPVNGAMYPPRGPSRMRRPSDASSARGPPAADPYAIPPSPGVANNGDYNRPMPKQPQNNTIIPNKSTMLEEDDDNAADDDGGDVFSLERVADAPNGKRIGDGRQSDESDKKRIEEYQAQVRELQEKLEGMEDVMRRKDDELSSVLDGERSRATAENLEKKELTGLRLKLENKLAEAQNLNKSMKEELDRVRQDHDEETRLLREELQQSSRGGGRRGNVSADVQRENDELRESLRQQRQVTDEVRREAQEFLREMRSLSQQSEATYEKQASMEKTIEQLEREVRNWRNRYERTKTQLRNMRASSLGLPREQDAAKYVRDKGFLSGGGLVKDVHVVKFQTAIDELLQTARQETPEKATDAMKLVVVSVRRITRDVDESVPNDDELAQQQARLKAKVSSTANSLITASKNFAAGAGISPVSLLDAAASHLTAAIVELLRVVKIRVTPAGELEDDDDGTMTPVDSTAFFSPRSLTQAPTQENLPPPPPFQGIGNMRASAESSAYSPVSSPRASVERYQDGGGMDYMGLKGYGMQQQRAYGAYGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LD69</accession>
    <name>A0A367LD69_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">MICOS complex subunit MIC60</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Mitofilin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">L249_0218</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n) + L-glutamate + ATP = (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)(n+1) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10580"/>
            <dbReference type="Rhea" id="RHEA-COMP:14738"/>
            <dbReference type="Rhea" id="RHEA-COMP:14740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:141005"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.2.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Mitochondrion inner membrane</location>
            <topology evidence="16">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the MICOS complex subunit Mic60 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LD69"/>
    <dbReference type="OrthoDB" id="10261039at2759"/>
    <dbReference type="UniPathway" id="UPA00850"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001447">
        <property type="entry name" value="Ras-related protein Rab-1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019133">
        <property type="entry name" value="MIC60"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004101">
        <property type="entry name" value="Mur_ligase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF5">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09731">
        <property type="entry name" value="Mitofilin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02875">
        <property type="entry name" value="Mur_ligase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01012">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 16" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Mur ligase C-terminal" evidence="18">
        <location>
            <begin position="1603"/>
            <end position="1739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="119"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="587"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="623"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="734"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="600"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="742"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU363000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RCI12365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1756" mass="192925" checksum="759BD1841DF2275D" modified="2018-11-07" version="1">MSARGSKGPYWAGPDEVLTRSDEGSYLPTLCLATVSSYAHPAYDIETPHSDKPGNNVAILFLAGVKFEQQGQERGAPRHLSLLTYPQSTLHILLTKRINTSLGIFIYLVATTMLHRPSASHKTRYQQTNQPQQSTTNHHPPTTIHQPPSPLASQSLTILSAPPLIDPSLLLIDIVSLSLDRLRSPRVLLPLPLGFRIYPLRRHSPSPGKRITMAARGPAAPRGINNRFAQFKLVLLGARACLLPHFSVFHADADFKGESAVGKVNDENASTVLRFVKVRPDQFDSFRESTIGAAFLTQTISLDENTTVKFEIWDTAGQERYKSLAPMYYRNANCAVVSSLDKAKAWVKELQRQANENIIIALAGNKLDLVNQQPDKRAISTNEAEAYAREAGLLFFETSAKTAENVRELFTAIAKKLPLDQVGPRHARPGQRPGVSLNPENANTNMASLNALHANHLVGLDGFSWADTSFFSLLLGFPYIILKFSSPMFFSQPVPASKCLLCRGKDVRMVSAWIRRQVQSLDKKKANFERVGDHVREFSRWNFVSSPASVEPSLAPTNSPCCDHRFGHTPAWRVMYELNSCNRPFSDKKTPGDASETPVLPSSQTLTSQRCAAPHGLGEAKLGAATKLPPTPPTPQEAAGGRDQPPTTLDDVGESKVLQKNAPPPPTPPPPRKSFARRLRNLVLSLVLLSIAGFGGGVLYSRSNDNFHDFFTEYIPYGEQAVLYLEEMDYKSKFPKGRGRASQVSGEDSKQVKISAQSGASWRVADSGEPSGRHSNASSRAKESAPTTPKVEPAKAEPTVSEPVAKPSKATPRIVDAGGKTVVASKEPEVNEPSKFLALKPIDLMSLPDAKEPIVRDLVRMVNDLILVINADGAHARYGTTMEKAKKDVANVGARLKAMKIAVEEKAAAKVKSSIGDFEKAATDLIQRVEKTMLAQEMEWRREFEQEMKTVRDGYDERVKVLLEQEKKLNETKVENKLLEQALALKRVFTQEVKSQVEQERKGRLAKLADMSSTVSKLEKLMAGWNEVLDSNLKTQQLHVAVEAVRASLEDGQNPRPFIKELVALKEIAADDAVVDAAISSVNPVAYQRGISTSLQLMDRFRRVASEVRKASLLPDDAGVASHASSWALSHLLFKKQGLAEGDDVESILTRAQTHLEEGDLDSAAREMNGLQGWAKTLSKDWLGEVRKVLEVQQALDVIATEARLQSLRAVDIDALLLPIMPMLCRRSLPDDYPDHPSAIIRLLNPETNFTSLPPPSSYTSNLISHSLPSKMATFSRARWRTAAAKDGRRALSTKARTYDEALQKLESLPTNKSATTLFTNNSHEAKALNEDSLKEMRFWLRRSGHDLPDLARMRTVHVAGTKGKGSICAFATAMLLRAGRSVGTYTSPHLTSPRERVAVDGKPLGRQDFADAVFELDERLASVSTERPFFFRFMTLLAWRVFLKFGIRDVVMECGIGGEYDATNVLPGQAVSATVISQLEKDHVAMLGDSISSVAWHKAGIMKEGVRCFARHHPLASPMLRQRAVEKKAAALCEVDDEHLRLWPGVKDGLGAASFQKANQALAALAVREHLGLEAFDDDLLHSLLDLDPNLVAGLSEAHLAGRCQRLDQDGIAWLIDGAHTAESLAAVASWFASSLTSPEEQVVLVFNQQDRDPAPLLAALVSAVAQQTRRSDVFREALFTRNDRLHNVADQSVQKRAATAMGRLAPACRSKIVNNVSEAVSCIQHMPRPVRVLVTGSLHLVGSVLRLLDPDVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDI5</accession>
    <name>A0A367LDI5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Potassium channel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_1162</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDI5"/>
    <dbReference type="STRING" id="1330021.A0A367LDI5"/>
    <dbReference type="OrthoDB" id="9999863at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140107">
        <property type="term" value="F:high-affinity potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051143">
        <property type="entry name" value="TrkH_K-transport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064:SF5">
        <property type="entry name" value="POTASSIUM ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064">
        <property type="entry name" value="POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI12477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="12615" checksum="F502320F3529CD8B" modified="2018-11-07" version="1">MWKPNFLLLHYAAITVLALLAVPILYPAGNMGFIDAFFMGFSSATNAGLPTVDCSRLALHQQLYIYLVPIVCNAGFVQVVMVAFHLRRLRSRLNGHCSAMSSSSSSSSSYRGGGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDT6</accession>
    <name>A0A367LDT6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PLAC8 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDT6"/>
    <dbReference type="STRING" id="1330021.A0A367LDT6"/>
    <dbReference type="OrthoDB" id="1045822at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006461">
        <property type="entry name" value="PLAC_motif_containing"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01571">
        <property type="entry name" value="A_thal_Cys_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15907">
        <property type="entry name" value="DUF614 FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04749">
        <property type="entry name" value="PLAC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="23760" checksum="06E67559076A1803" modified="2018-11-07" version="1">MDSSQQQQQQQQQQQQQPPAPPAPPPPQQQQQQQQTFPQQQRMEREDGWQHNLCDCSPCSSCLIGYFLPCILSGRAASRMRDPTMESHSDLNGDCVIVGLLHYFTGFAWVHNMFQRAEIRHRFGIRGSGCDDYCASYWCLCCSVIQQDKEVQRRLSPPGGGGPVTNPYSSDKERMQVPAAAAAAAPAYQPLMVQPQDTGTVPQAPPPSKETRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LE26</accession>
    <name>A0A367LE26_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_1000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LE26"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI12678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="438" mass="47505" checksum="3CD305C5FA66ACEF" modified="2018-11-07" version="1" fragment="single">LHFGGSARHSHTHTQGTRPEGLGGSRDAGPAAAGPRPPYVTAAEQHNNVGGGYGYGYGTATLYSGYGRTGRTGRTKEGTRRLRLRLWHGYAVQRLRPYGPYGPYEGRNPIKAIAAAAAAAAADPEGLFDYRLLRGGEDEGPALADLETFFLPIAGELTADSTLFFFDLSGSYGYSKRPRCYSSSTASSFPLKRSLRPDFFGCFFRPLVFRPFLPSLFFLRPALRPIATTGTGSGSGSGSGSGLAAEYGYGPGIAVIIAVTIAVITAVITGTTAADDRTYGRTVPTPPTVVTFVFVFVFFFFSSGVFRRPFLRYLLLRLFLPTALPPPYDLFKEGEFSSSSINSRKKSRIEESISYLSSSPPPAYGKYRSLRKTYLSRQQRQPSYGTTEHLIRSLEKHAFLCRKIGSSYGPGPGPGPGPDESIEHSYGLFQALPKEIQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LE44</accession>
    <name>A0A367LE44_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hyaluronan/mRNA-binding protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LE44"/>
    <dbReference type="STRING" id="1330021.A0A367LE44"/>
    <dbReference type="OrthoDB" id="2122308at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="126" mass="13786" checksum="F6060DA27361095A" modified="2018-11-07" version="1">MTRSHKANDRDHKGLADGTAAHSEHLPRFFARTGHLDTDPKKVKKDGGGKGNWGNVGEEVMDEDFRFTNSRRRSNSSSVSHIGDFKTKFEVNEPEPVFEESIHGPADETGDDLSKTDSSESGGSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEA3</accession>
    <name>A0A367LEA3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_0524</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEA3"/>
    <dbReference type="STRING" id="1330021.A0A367LEA3"/>
    <dbReference type="OrthoDB" id="4088568at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="333"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="606"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="645"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="60"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="257"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="608"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="658"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI12751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="714" mass="77979" checksum="2FC4D766C6DBE14C" modified="2018-11-07" version="1">MAQCPPPRSISWQGCPESVTSTLYCCCGRVDCVFLKKNCSILETVEKDVHTAAQLGQALLARHEAYMADAERDRLELTDRIEKLERDKQGLEAANADKIEENRSLLDQLEALNSTISDSDTKIKVLEASLLSSQQAVRRLEAAAARAADAERHIAVLEEEQAKLHLELRSTRDDARTHAQRFKEAQRGILDMQDQLERMEEEARQENQRHAEVIGRMERQREIDRQLDTAAGRIKGAAATKTLQEQKSSNKIVGHFVRDLLEDNANLQLAMAELREMLMSSNDEIQLLRDQIMHHQPICQDDDGPPPTLKDELETAHDMASLSQELHIHHHYHQAVRSPRKQDVRKPRKRRHGFLPTACTSPATLSPKPSAHWAAPVSSPAAPALLSATVGETTLVAPRPRHSWGGMSSMVSDFSSSAPNSPPSKRASVVFDQAVVDADGVASPATSFDPMSPTWGTIQSKRSSGCSSRSFQSMSMSVMEPGPVTPCGKQPARHAFPENTIHEEDEDEDGSQELGKDAELVVDASEDQKSDATTCVRLLRAPSHESIMSLAGGLEIHTLRSRPSQMTLRRLGGADAVVTGVTARPTLSHASGKRSDVALRDHFAGLHSPRSVSSPQRPSPGSSPASVGGAGTFGRLVGWRLWPSGGSRPSSPLNLSKPPDKDKDKDVGRVPGINQPGAIPGFQHYWAAQKRKGAPAQVTASVVDQEALHEGLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LET4</accession>
    <name>A0A367LET4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycoside hydrolase family 92 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_0930</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LET4"/>
    <dbReference type="STRING" id="1330021.A0A367LET4"/>
    <dbReference type="OrthoDB" id="449263at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1610.10:FF:000002">
        <property type="entry name" value="Alpha-1,2-mannosidase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2080.10:FF:000001">
        <property type="entry name" value="Alpha-1,2-mannosidase subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.60:FF:000002">
        <property type="entry name" value="Glycosyl hydrolase family 92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.60">
        <property type="entry name" value="alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1610.10">
        <property type="entry name" value="alpha-1,2-mannosidases domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2080.10">
        <property type="entry name" value="GH92 mannosidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005887">
        <property type="entry name" value="GH92_a_mannosidase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01180">
        <property type="entry name" value="aman2_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF25">
        <property type="entry name" value="FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G10790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016901503" description="Glycoside hydrolase family 92 protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92 N-terminal" evidence="3">
        <location>
            <begin position="30"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92" evidence="2">
        <location>
            <begin position="282"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI12935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="795" mass="87085" checksum="42F19641DE43B698" modified="2018-11-07" version="1">MASSLLIQVLIIVVSAVKAQPPPPFDPLDYVDPLIGSINGGNVFAGATVPYGMAKAVADTAGQGTQGGFNFDGRPVTGFSLMHDSGTGGASSLGNFPLFPFASCRGDDVNGCDFPKRNRSRFGSYRRETVEARPGYFGLTLVSGPRVEMTTARHTALFRFGFGRDDKPLILQDLTDLSDSRQDNASVKVDAAARRITGDAVFSPSFGRGRYRAFFCTDFDAAGRHVVDSGIFVDSRASTAVQELLISRDMTPLPGGAFMRFAPGDDRPVLARVGISLISSRQACANAESEMPTWDFEGHRAAAADAWRRKLAPIAVDATGVDRMFVRTLYSGVYRTMISPQNYTGENPLWDDGDDGEPYFDSYYCIWDLFRSQMPLLTIIDPDALAQMIRSLISIYEHDGWMPDCRMSLCRGYTQGGSNADNVLADAFVKGIKGGIDWHKGLDAAKKDADVEPFDWSSRGRGGLDSWKALGYIPVRDFDYKGFGHHTRSISRTLEYAYNDFCISQLAAGLGRTADAERYLGSSGNWRNLWREDQASHRSNGSDTGFTGFFQPRNLNQTWAWQDPLRCSAIDDSGATCSLQPESSETYEGSIWEYGFFVPHAQAELIKLCGGPDAYVRRLRYLHDNGIDDVGNEPSFLTSFQYHYAGRPALSAKRVHDLIPKRFSDTPGGIPGNDDSGAMGAFAFFCMMGLFPNPGQNVYFIVPPFFRTVNVTSPLTGKTATVRAVNFDASYRDVFIQSATLDGKPYSKNWLDHSFFTEGKELVVTLGGRESAWGTAVEDLPPSLGSYAVGGKMKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEY3</accession>
    <name>A0A367LEY3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Splicing factor Cactin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_0484</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CACTIN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEY3"/>
    <dbReference type="STRING" id="1330021.A0A367LEY3"/>
    <dbReference type="OrthoDB" id="265955at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019134">
        <property type="entry name" value="Cactin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018816">
        <property type="entry name" value="Cactin_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737">
        <property type="entry name" value="POLYGLUTAMINE BINDING PROTEIN 1/MARVEL MEMBRANE-ASSOCIATING DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737:SF4">
        <property type="entry name" value="SPLICING FACTOR CACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10312">
        <property type="entry name" value="Cactin_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09732">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01050">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Splicing factor cactin central" evidence="5">
        <location>
            <begin position="52"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Splicing factor Cactin C-terminal" evidence="4">
        <location>
            <begin position="342"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="251"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="261"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="284"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00034534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI12977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="479" mass="55611" checksum="A02C739C3CB9A5BD" modified="2018-11-07" version="1">MDPGRREMMAKKARSNHSQNITRPRADHKTRVAKRDVYKRDKDKGKASRYLTADQQSLNYVADEDRFVLKQSKKKADIRVREGRAMPIDRLAFNLRYMDKERDVFDDDDDDIQIELQAPETIVEQLATDQLDQLQSDMESLLVLEADPTNRQYWEALQALCKDQKSKLGPQGREDRVLSSVAEDIDRILKPKTHDQLEALETQIKAKLRSNEDIDTDYWEQLLRNLVVWKSKATLRRIFQTAVEAREKLLKEKRSSGKQGGEQQQPRSSTQLSVVPRPIGLPDKPGPPPPAPAPGGRPSDNNEDASQATKALYDREAARGISENEEIFTAEEAVPAYVKPRWVDRRGARKPRYFNRVQMGYEWNKYNQTHYDHDNPPPKVVQGYKFNIFYPELEDKTKAPTFKIIREHGRRRGQSHAAAGEADTCLIHFIAGPPYEDIAFRIVDREWDFSAKRERGFRSTFDRGILQLHFQFKKIFYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEZ8</accession>
    <name>A0A367LEZ8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_0015</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEZ8"/>
    <dbReference type="STRING" id="1330021.A0A367LEZ8"/>
    <dbReference type="OrthoDB" id="69269at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004177">
        <property type="entry name" value="DDHD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058055">
        <property type="entry name" value="PA-PLA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509">
        <property type="entry name" value="PA-PL1 PHOSPHOLIPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509:SF6">
        <property type="entry name" value="PHOSPHOLIPASE C1020.13C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02862">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01127">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51043">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDHD" evidence="2">
        <location>
            <begin position="774"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI12995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="997" mass="109723" checksum="27FDDA1415E7AA04" modified="2018-11-07" version="1">MEVKQGGAAMTASKHTLATNCRLAPVRRTPSDSGCPPLEAQFFYSSLIPIDDPLSSNPIVTGHETKSTWRQLRPFGRGDNNALENAWLGLYSENHRKQHLESGAGRHKTCAVAATALTMRDQLVSMLASRHLERHGVESRSHHSIGHTEHTAVGIDVISCCSELVVDVSEELENNFCALIRTQLDELSMENLINDVVKAMDSLRAITEVQSGAPKTVPLNRPRSRQSSHAANRDLKLQTKADVVKGKENDTESQDSLGTLRSPRLNTISSHPSGSLPASASSDDGMSRTPFARVERVTAPSLSGPLPSSRIKSPVSEPAELGEGGHLAASAKTTYRAPKLVNAFDVGDRAKPTEIVVGLSRLHKVSLPALQMLPIYWSPVNDVAVVMRATWFYRDTMVPVPPTVANQLETGFQELRPWTETWADELRCAIEVGPLGEEKVSYCLWPNSLEQKQDETEPKISSNPFCAARCCQGEAAAQGANNPTTERPPKEAPNRPFANYHVIFKDKSQAFLLKQSLKPSAYYGRKPVGKIMRGISVGIPLTRGFDQEAWDSDHGKPRTLGSSAVEDSHESTRLSVCPACMADTSRGQVNDLVLVAHGIGQKFAERVESFHFTHAVNAFRRAVNMDMASPSVQSVVRKGQNGLMILPLNWRMGLSFEDGGPLQQGASEHVPESFALKDIEPDTIPAVRSMMSDVMFDIPFYMSHHKSKMIRALVSEANRVYRLWCKNNPGFFEKGRVHLIAHSLGSVMALDILSHQPTTVPKMDLSRELDARHFEFDTKNLFLLGSPAAFFLLLERKALIPRRGRRKPGADPADVMTKNVTGHAGTLGCLAVDNIYNILAKEDPIAYLLNGAIDPNFSASLKTAYVPSTYTSLLKSVSDAVRNVVPGLSPALPIPLDRPPTLRLPSQLELEVHDFTREEIAEKKAFLLNDNGQIDWFLRSGGGPLEIQYLNMLSAHTSYWTNQDFIRMLCIEIGRESGRASTLPAMRAVKAAKRFTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LF45</accession>
    <name>A0A367LF45_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">LEM3/CDC50 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_0997</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CDC50/LEM3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LF45"/>
    <dbReference type="STRING" id="1330021.A0A367LF45"/>
    <dbReference type="OrthoDB" id="340608at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005045">
        <property type="entry name" value="CDC50/LEM3_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926:SF0">
        <property type="entry name" value="CDC50, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03381">
        <property type="entry name" value="CDC50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015840">
        <property type="entry name" value="DUF284_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI13037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="428" mass="48148" checksum="B3116537CF888BA1" modified="2018-11-07" version="1">MSDSPPGVGHADSIDSRELSPKHSEKKKSRRPANTAFRQQRLKAWQPILTPKTVLPLFFTIGIIFAPIGGLLLYASSKVQEIIIDYSRCSTDAPVDSFDAIPKDRVSTAFKSNNKSVDARWSRRENVNVEVPNSGGVRVPTTICTIQFNIPDKMGPPVLFYYRLTNFHQNHRRYVDSFDQDQLKGDAVPYDKIRSSKCNPLYGANVSGEMKPYYPCGLIANSLFNDTYTQPVLLNPPGARGNETRTYVMTQNGIAWNSDKALYGETKYKPNECLPPPNWKLRYPDDYTSENPPPNLKEWEEFQNWMRTAALPSFSKLYQRNDNESMVDGRYEIKVNDYFPTVDYKGTKSIVITTRTVMGGRNPFLGIAYLVVGGLCILLGAIFTATHLIKPRKLGDHTYLSWNKVPASRPAMASTAVASGREIRPNDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LF57</accession>
    <name>A0A367LF57_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pal1 cell morphology protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LF57"/>
    <dbReference type="OrthoDB" id="5389892at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013226">
        <property type="entry name" value="Pal1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307:SF1">
        <property type="entry name" value="PAL1 CELL MORPHOLOGY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307">
        <property type="entry name" value="PROTEIN PAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08316">
        <property type="entry name" value="Pal1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="28898" checksum="C5D9A8799A542AF9" modified="2018-11-07" version="1">MPSSSTTTTTTTTTTTTTTTTTPTPRIRRPRNNHQRPYYTDSIDALDTSHGATRYHHAGPYEAALPIRNRNPRHSALAATHGSNMEALRATPRENILDSLRSHKPLQGVASIPPGGTDGLGNTMQYEEGSDLMRDADAAGGPYKRWPDVDYHPEDLKGKGEPAYTTAAGRPKRHSLPARPLIYASSCSSSSPAPRSSEVESDEGRGYRRRRYHPNSLARVWLTDGIARRLGSVRRRCSKKKKTDRREEHHQEEHHQEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LF77</accession>
    <name>A0A367LF77_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ZIP Zinc transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_1112</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LF77"/>
    <dbReference type="STRING" id="1330021.A0A367LF77"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF24">
        <property type="entry name" value="FE(2+) TRANSPORTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="317"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI13070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="35999" checksum="0970032E9B8F879A" modified="2018-11-07" version="1">MADQPKPQCGSEKQDEGYDLGLHVLGCGFPVAAKKIRWMKIPPKIFFACKHFGTGVLIATAFVHVSLNLESPLNHKLLPTAFESLGDPCLPDLFTEKYPPLPGVIMMASMFCLFVIEMVLNAKTGGHSHGGPTGADITVNDKASEVTSSTAQAADSPPSEAMFVNEDGKEMTEAEFKKMSTNISLLEGGILFHSIFVGMTVSITVDGFVVLLIAILFHQMFEGLGLGSRIAAVPYPKRSIRPWLLVVAFGTTAPIGQAIGLVSRNSYDEKSALGLIIVGVFNAISSGLLLYAALVDLLAEDFLSDEANHLMDGKKKAIAFCWVLFGAAGMSVVGIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFA1</accession>
    <name>A0A367LFA1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_0134</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFA1"/>
    <dbReference type="STRING" id="1330021.A0A367LFA1"/>
    <dbReference type="OrthoDB" id="1434354at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.20">
        <property type="entry name" value="N-terminal domain of phosphatidylinositol transfer protein sec14p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051026">
        <property type="entry name" value="PI/PC_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657:SF1">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00180">
        <property type="entry name" value="CRETINALDHBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="97"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI13109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="326" mass="37223" checksum="C568D6C8341EF939" modified="2018-11-07" version="1">MDLNDKYDDYDFPHTAAEKKDGHAGHLTQDQIAQVHQLRMMLESEGYTERLDTLTLLRFLRARKFDVAQSKQMFVDCEKWRKDTKLDDEVPNWTYPEKKDVAKYYKQFYHKTDKDGRPIYIETLGGIDLKAMYEITTSDRMLTNLAVEYERLADPRLPACSRKAGNLIETCCTVMDLKGISLTKMPQVRQYVNQVSVISQNYYPERLGKLYLINAPWGFSTVWNIIKGWLDPVTVAKINILGSGYKTDLLKQIPEENLPKAFGGTCDCPGECENSDAGPWRDPAWAKPAKWESRAKKGTDDKASEDKQAEAETATDKVEAMQPAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LG27</accession>
    <name>A0A367LG27_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_0302</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LG27"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI13383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="108" mass="12131" checksum="B1E759F7826E182A" modified="2018-11-07" version="1" fragment="single">TCWHCVAGREKKRNRIVAEAQASDRKQIHMTLALRPLFLRKQESFESSFFLSQLPLSQKTSFRLRCTLEQKEEKARAAKPTVALIAQPPLPPLFPAAAVSSASRVEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LG72</accession>
    <name>A0A367LG72_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5613</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LG72"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI13418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="197" mass="21980" checksum="16C90760F3E92C16" modified="2018-11-07" version="1">MMMSNQGVDHVIEKKKTNHVMVVLSDEVEADNKLEVDFNVMDQPDDLTLYSAPIDVTAALCRDQSGAMTAIGTARRSLPTVTQGVVAGLRPNWYNLFQGPNEIICGAKGKEEGGEKKVEMDEELTNREGDHVIEKKKRNHVIKVRKADADNSSKYFSRYFKVPTCSTLTYLYKIGDLEEDLYVPYPAVICGSGNDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGD7</accession>
    <name>A0A367LGD7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_5489</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGD7"/>
    <dbReference type="STRING" id="1330021.A0A367LGD7"/>
    <dbReference type="OrthoDB" id="1158011at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23799">
        <property type="entry name" value="UBCc_UBE2J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000093">
        <property type="entry name" value="Ubiquitin conjugating enzyme (UbcF), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="276"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="4">
        <location>
            <begin position="17"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="171"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="249"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI13480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="299" mass="32567" checksum="20EC96BD2F656010" modified="2018-11-07" version="1">MAASKPTTASQVSTKSPTIRRILREAAEISNSPSPDYTAEPLDSDLFEWHFTFRGPPNSVYSQGIYHGRIILPPTYPLRPPSFRFTTPNGRFEANREICLSISGHHEETWQPAWGIRTALVALRSFMETDAKGQLGGIDTTDAVRRRLAQDSGSFRCLTCARSNQDIIVDSERHAQSTKSSSEEVKVPQELSMGWRDELESGNKDKTVSDTAAGPGNDPESKAKDDRQNPTGTETVAGLAAAGGDGHVPTQSAPRLPQLSNQRPATPRNRSVVPLWVDRAIAALIVLLVALLLKVLMGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGI9</accession>
    <name>A0A367LGI9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Xaa-Pro dipeptidyl-peptidase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_5600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGI9"/>
    <dbReference type="STRING" id="1330021.A0A367LGI9"/>
    <dbReference type="OrthoDB" id="10260961at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42103:SF2">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42103">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xaa-Pro dipeptidyl-peptidase-like" evidence="2">
        <location>
            <begin position="25"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="262"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI13554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="387" mass="41557" checksum="45D1AE09123D1837" modified="2018-11-07" version="1">MSVSPSNHGRRPIPTLSLTIPSLYDGTPLDCRLYHPVSLSSDAHSLHWRGDVAVVAHPYAPMGGCYDDAIVEAIVFQLLEAGFLVGTFNFRGAAHSAGKTSWTARPERDDYASFVAFLAHYTTRIQDAPQDAILLMGGYSYGAMVTTQLAPLDSLLEPLVAPSPGSNAADIRLRAEQLALQAGMTMSRSATGMKRFGGGDQRRRKSCDGASLVSEHHHSRLPRSVCDIFARTRPRHHQQHERGRRRWMTRVSVDDDEKLRAKSAPAPMTPTSPSRRPRAAYLLVSPLQGLASRLATLSTSSSSSATTTSNLVANPSLAIYAGRDALVPAAKVRSWASRLAAAPGSQFRALEVARAGHFWTEDGALAEVEAAVASFAAGLTSQSDGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHA2</accession>
    <name>A0A367LHA2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7981</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHA2"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI13779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="127" mass="14377" checksum="550D84D16A34A2C1" modified="2018-11-07" version="1">MRQEPSSLLPRSGDEAIFKCKALSRAIVHPYSILSWQNHAPTFVLSEWAAQPLTHATRLGKGGGLAQMHGCCKRRRQCIQCWTPSPMPPARYIRRAPNRSKSSIPLFFLTNFLPLCRSSLPYCRAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHB5</accession>
    <name>A0A367LHB5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Clp R domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_8002</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ClpA/ClpB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHB5"/>
    <dbReference type="STRING" id="1330021.A0A367LHB5"/>
    <dbReference type="OrthoDB" id="47330at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070370">
        <property type="term" value="P:cellular heat acclimation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043335">
        <property type="term" value="P:protein unfolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19499">
        <property type="entry name" value="RecA-like_ClpB_Hsp104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000120">
        <property type="entry name" value="ATP-dependent chaperone ClpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000025">
        <property type="entry name" value="ATP-dependent Clp protease subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000010">
        <property type="entry name" value="Chaperone clpB 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1780.10">
        <property type="entry name" value="Clp, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019489">
        <property type="entry name" value="Clp_ATPase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036628">
        <property type="entry name" value="Clp_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004176">
        <property type="entry name" value="Clp_R_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018368">
        <property type="entry name" value="ClpA/B_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028299">
        <property type="entry name" value="ClpA/B_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF18">
        <property type="entry name" value="HEAT SHOCK PROTEIN 104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02861">
        <property type="entry name" value="Clp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10431">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01086">
        <property type="entry name" value="ClpB_D2-small"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81923">
        <property type="entry name" value="Double Clp-N motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51903">
        <property type="entry name" value="CLP_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00870">
        <property type="entry name" value="CLPAB_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00871">
        <property type="entry name" value="CLPAB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clp R" evidence="10">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="891"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="431"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="897"/>
            <end position="926"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI13815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="926" mass="103376" checksum="4D17EDC810065681" modified="2018-11-07" version="1">MNARMDFTDRAQKAVEDSMALAEQYAHSQLLPVHLAVALLEPPVDQSKDQQNGPAQPTVTLLRQVVERARGDPQLFDRALKKMLVRLPSQDPPPEHISPSPSYHAVLRKAMELQKVQKDTYIGVDHLITALAEDSNIQQALRDSNIPKAKLVQEAVQAIRGTKRVDSKTADTEQENENLAKFTIDMTAMARDKKIDPVIGREEEIRRVVRILSRRTKNNPVLIGEPGVGKTTVVEGLAQRIVNRDVPDNLKHCKLLSLDVGALVAGSKYRGEFEERMKGVLKEIEDSKEMIVLFVDEIHLLMGAGSSGEGGMDAANLLKPMLARGQLHCIGATTLAEYRKYVEKDAAFERRFQQVMVKEPTIPETISILRGLKERYDRHHRVTILDSALVAAANLAARYLTSRRMPDSAIDLVDEAAAAVRVARESQPEIIDSLDRKLRQLMIEIAALEKEHDEASKTRLQQARKDAQNVEEELEPLREKYQNEIKRGEEIHQAKVKLDDLEKRLEDATNNGEHVKAADLKYGAIPEQEAVIKELEARKVAADAALNATGADTGSSMVTDVVTADHINEIVARWTGIPVTRLRTSEKEKLVNMEKVLGKVVVGQKEAVQSVANAIRLQRSGLSNPNQPPSFLFCGPSGTGKTLLTKALAEFLFDDAKAMIRFDMSEYQERHALSRMIGAPPGYVGHDSGGQLTEALRRRPFSILLFDEVEKAAKEVLTVLLQLMDDGRITDGQGRVVDAKNCIVVMTSNLGAEFLTRPEAREGRVDGPTRELVMNALRNYFLPEFLNRINSVVIFNRLTRREIRKIVDLRLSEIQKRLEDNGRKVRIEVSDEAKDYLGSSGYSPAYGARPLSRLIEKEVLNRLAILILRNNVRDGETAMVELDDGKIVVLSNHTDSEGGEDEDMMDDEDDAVDELVGDNMDEDIYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHD6</accession>
    <name>A0A367LHD6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5512</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHD6"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI13662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="89" mass="9758" checksum="50D1780B09B4C7DC" modified="2018-11-07" version="1" fragment="single">GYSGHVIAVIAGQIDRIDRIDQIDQIGQIATSYKPGFSSLTRDTFILATSFSPPSSSPFALQITLFGPSLPTLFSKQTHLSLQNFLFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHI9</accession>
    <name>A0A367LHI9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidyl-prolyl cis-trans isomerase-like 2</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
            <ecNumber evidence="7">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Cyclophilin-60</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Cyclophilin-like protein Cyp-60</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">RING-type E3 ubiquitin transferase isomerase-like 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">L249_7942</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins. May also function as a chaperone, playing a role in intracellular transport of proteins. May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EC" id="5.2.1.8" evidence="7"/>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHI9"/>
    <dbReference type="STRING" id="1330021.A0A367LHI9"/>
    <dbReference type="OrthoDB" id="407558at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16663">
        <property type="entry name" value="RING-Ubox_PPIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000079">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000014">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase cyp65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026951">
        <property type="entry name" value="PPIL2_U-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF1">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN-PROTEIN LIGASE PPIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0697">Rotamase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="19">
        <location>
            <begin position="41"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="18">
        <location>
            <begin position="327"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="508"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00020592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RCI13904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="580" mass="64205" checksum="DBBC498110D2B797" modified="2018-11-07" version="1">MGKGTDKLYITHSEWSSSDAYSASVGANASSRGSSHGVPFRRLPFNYCAASLQPFKNPVCTPDGTVFDVEVIGAWLDKHPNQNPVDGKPLLKKDLIKLNFARNSEPDSLAGKSGLVDPVTYKVFTDNTHIVAIRHGTYANVFAWETIERMNIKPKLWQDLVNDEPFKRTDIITIQDPRTTAGRDLELFKYLKDGQTAQLTKEQQEARDASNINADALGSMGDKISKARAAVEKARKAREAGTDVNRSAGALTKTSGALVPAAHSKPAIQQKKQAPNAAAYTTGRAAASFTSTGLTPETSGERALLSDEEFMLKPRRVKNKGYVKMMTNLGDLTIELQTETAPKAVWNFIRLAQKGYYEGVAFHRNIPDFMIQGGDPSGTGKGGSSIWEKYFDDEFEGPLTHNARGIGRQPLFPDENFACWKNTNSSQFFITYKPASHLDRKHTIFGRIQSGTEVLSKMEAIPTDGSNRPLNKILINKMVVLIDPFDEFQAQRREELRLQQEREDIRMRGGTDDDKTTWTGKRIRPDGSRQEGAADDLGVGRYLKDNAVRSAGGEVVDSWEEPVKKKFKGGGAEFGNFDSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LI13</accession>
    <name>A0A367LI13_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LI13"/>
    <dbReference type="OrthoDB" id="10450020at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="83" mass="9010" checksum="37318FDD899AA21E" modified="2018-11-07" version="1" fragment="single">MARSVVSVESYTDSRRTAATNSEDDDDMTMMMRDLGKASRSATGAEEDPNSSARGAGPAMRAWTLPTLWVVQQRSTFAHGEPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LI66</accession>
    <name>A0A367LI66_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_8120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI14111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LI66"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="74" mass="8302" checksum="DC58A11FF8042A83" modified="2018-11-07" version="1">MRYNVLVRASRRELIVYSTDNLFLATSLREISLALRITPTPKAPPIISLPSKVSNFANLFSKEKASALLPYYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LI72</accession>
    <name>A0A367LI72_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 13">Tryptophan synthase</fullName>
            <ecNumber evidence="5 13">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L249_6053</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + L-tryptophan + H2O</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the TrpB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the TrpA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="5 13"/>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LI72"/>
    <dbReference type="STRING" id="1330021.A0A367LI72"/>
    <dbReference type="OrthoDB" id="10050244at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04724">
        <property type="entry name" value="Tryptophan_synthase_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000151">
        <property type="entry name" value="Tryptophan synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000001">
        <property type="entry name" value="Tryptophan synthase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000004">
        <property type="entry name" value="Tryptophan synthase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00131">
        <property type="entry name" value="Trp_synth_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018204">
        <property type="entry name" value="Trp_synthase_alpha_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002028">
        <property type="entry name" value="Trp_synthase_suA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00262">
        <property type="entry name" value="trpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077:SF3">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00290">
        <property type="entry name" value="Trp_syntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00167">
        <property type="entry name" value="TRP_SYNTHASE_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10 13" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="9 13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="14">
        <location>
            <begin position="359"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCI14136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="708" mass="76245" checksum="11A2DF9992E48A8F" modified="2018-11-07" version="1">MEAIKQTFKRCKAQNRPAMITYVTAGFPRPEETPSILLAMEKGGCDIVELGVPFTDPIADGPTIQTSNTVALSHGVTIESTLGMVKEARNKGLKAPILLMGYYNPLLSYGEDRLLRDSEDAGINGFIVVDLPPEEAVSFRKLCNRGGLSYVPLIAPATSDTRMKILCQLADSFIYIVSRQGVTGALGFLDSRLPELVKRVKQYSGNKPAVVGFGVSTKEHYQSVSELADGVVIGSQIVITIQKAAVGEEATAVQEYCASMSLGRIETTREVGLAEAITEAESPKGHGVTVNAVVTEDDRITAEQDSALVAQLAALHGRIPERFGEFGGQYVPESLMDCLSQLEEGFNQEYRSYYDYMGRPSRLHLAERLTDHAGGANIWLKREDLNHTGSHKINNALGQLLLAKKLGKTKIIAETGAGQHGVATATVCARFGMECTVYMGAEDVRRQALNVFRMRLLGAKVVAVEAGTKTLRDAVNEALRAWVVELDTTHYIIGSAIGPHPFPTIVRTFQSVIGNETKKQMMEMRGKLPDAVVACVGGGSNAVGIFYPFSNDTTVKLLGVEAGGDGIDTARHSATLTGGSKGVLHGVRTYVLQNSHGQISDTHSVSAGLDYPGVGPELSSWKDNQRAQFIAATDAQAFTAFRLMSQLEGIIPALESAHGIYGAIELAKTMKKGEDVVICLSGRGDKDVQSVADELPKIGPLIDWDLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIC8</accession>
    <name>A0A367LIC8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_6016</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIC8"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="74" mass="8341" checksum="31B22D1CB1B20BBD" modified="2018-11-07" version="1" fragment="single">GKKGPNEVICIPSQRAKPGLITSKGYISKKKKRNHVIKVRKANADNSSKYFSRYFKVPTYSTLTYLYRCAQGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIL4</accession>
    <name>A0A367LIL4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_6158</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC10 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the band 7/mec-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIL4"/>
    <dbReference type="STRING" id="1330021.A0A367LIL4"/>
    <dbReference type="OrthoDB" id="2105077at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08366">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13437">
        <property type="entry name" value="SPFH_alloslipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000004">
        <property type="entry name" value="Putative membrane protease family, stomatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2090">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016901">
        <property type="entry name" value="APC10/Doc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004939">
        <property type="entry name" value="APC_su10/DOC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043202">
        <property type="entry name" value="Band-7_stomatin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001972">
        <property type="entry name" value="Stomatin_HflK_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264:SF19">
        <property type="entry name" value="AT06885P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10264">
        <property type="entry name" value="BAND 7 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03256">
        <property type="entry name" value="ANAPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00721">
        <property type="entry name" value="STOMATIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01337">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51284">
        <property type="entry name" value="DOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DOC" evidence="7">
        <location>
            <begin position="103"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI14276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="578" mass="62538" checksum="26FC2941017B4D8E" modified="2018-11-07" version="1">MDPVRGSRRRLAPDATPPTASTTVLTSPPQQPFRGPRPRLSMPPLGSEDSDSEPDVSVLAAASRAAAAGAAAAGDAFAEADAAVDDDDQVLEQYEVEDTSVEEQAEEEQNEEAVPLVDPLAIGLKEISNLGKFTVSSHKPGCGVEELRSEDLKLYWQSDGPQPHKLTVYFVKRVGIREIRFFVDYHQDESYTPTKMVFKSGTSENNLMEFATMTLESPVGWQQVPLAGTGGEPDGNTLVSYVLQMQLRLIQSPKRSYKDVISAVTEGLRGSSKSYARIVGDDDANPKGWYGSMIHALGSLIGSVGAVPCCICFPNPYKNVYQGNVGLVTKFGRFYKAVDPGLVKVNPLSERLYQIDVKIQTVEVPEQICMTKDNVTLRLTSVIYYHIVAPHKATFGISNVKTALVERTQTTLRHVVGARVLQDVIERREEIAQSIGEIIEDVAAGWGVQVESMLIKDIVFSLDLQESLSMAAQSKRIGESKIIAAKAEVEAAKLMRQAADILSSAPAMQIRYLEAMQAMAKSANSKVIFLPGNANAAHNVLDNLDGSSGAGGATASSTSKQQDPGFLQAIAAHNVEHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIN9</accession>
    <name>A0A367LIN9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquitin-activating enzyme E1-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">L249_6154</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">BCC 54312</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2 11">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Heterodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIN9"/>
    <dbReference type="STRING" id="1330021.A0A367LIN9"/>
    <dbReference type="OrthoDB" id="10255449at2759"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01489">
        <property type="entry name" value="Uba2_SUMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000618">
        <property type="entry name" value="SUMO-activating enzyme subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.80:FF:000002">
        <property type="entry name" value="SUMO-activating enzyme subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.80">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.20">
        <property type="entry name" value="Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028077">
        <property type="entry name" value="UAE_UbL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042449">
        <property type="entry name" value="Ub-E1_IAD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030661">
        <property type="entry name" value="Uba2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF5">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14732">
        <property type="entry name" value="UAE_UbL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039133">
        <property type="entry name" value="SUMO_E1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8 11 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="17">
        <location>
            <begin position="44"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin/SUMO-activating enzyme ubiquitin-like" evidence="18">
        <location>
            <begin position="480"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="574"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="12 15">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="60"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="92"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="153"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="472"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR039133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR039133-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR039133-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR039133-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF14732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RCI14270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="651" mass="71591" checksum="93A064A1CE83AB5B" modified="2018-11-07" version="1">MDEAVANPPADASSAPTPSTTDASAQQKSRIMPPRDRFNHQSLGVTLNTSVKQSRVLMVGAGGIGCELLKNLVLAGFGEIHVVDLDTIDLSNLNRQFLFRQEHIKKSKALVAKEAAQKFNPGVRIVAYHANIKDSQFTVGWFRRFNIVYNALDNLEARRHVNRMCLAADVPLIESGTTGFNGQVQMIKKGVTACYDCSPKDTPKSFPVCTIRSTPSQPIHCIVWGKSYLLNEIFAASEDASAFDNSTNVDNAQEIEELKKEAQELKDIRAAVGTGPFPQMLFDKVFGKDIERLRSVQDMWKSRRPPEPLAYDTVMSRALDAQLSTEKILKQDQNVWSLEESLLVFVDSLDRLSKRMLELKKLKEPSAPEPAISFDKDDQDTLDFVASSANIRSAIFGIDCKSRFDIKQMAGNIIPAIATTNAIVAGVCVLESFKVLRGEFAQSKEIFLTPFAPARLLAPDSSRRPNPDCPVCGVFNATIAADLTRATLNDVVENVVRRELGFERREFSVSNDVGILYDVDETDNLPKKLSELGINAGSFLTVVDDDDENPMVDVVLDVEERTANDEENAAKMALEGPIDIPRKPAKSAPLEPRGDKQPDGDDDLTVSELKGVKRALPADDSQPTKRAKTADPKTEVVVVDDTDGAILIVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJC8</accession>
    <name>A0A367LJC8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">OPT family small oligopeptide transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_6668</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJC8"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="310"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="447"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="490"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="567"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="625"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="652"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="684"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="734"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="805"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="852"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="881"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI14521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="951" mass="106314" checksum="36D0C29DF48B225E" modified="2018-11-07" version="1">MAQQEQNQGGHDEDKKPESGAGKTSKVDDNEKEKPESEEENTMTTIDDDEKTEEHKSIITIDDDKLERQLTATEKTLIMEYGNDNSAFAGDMETQMFMSSSFMTSTYNEKELAESLSIFDEKTATECGSTVAYRKSVESLSKDHLTSQLEKLLEKHELDQNFPSDLLARARTFLRRRRDGRQTGAEDMAEDMAEGQKLMDDFRAYSELVRNSSPYMEVRSVVDITDDPSTPVGTFRVFLLGTLFSVAGSAMHQFFSLRLPSISISVFVVQLLTMPLGVAMARWLPEKREVGRGRFTFDLNPGPFSKKEHILIAMMANVAFGSPYVVSIVQVLKLDMFYGEKVLSNSLAWQVLTLVSTQLIGYGCAGLTRRFLVYPPSMIWPGTLATIALTRALRRDSGPPSKGDSPWGIMTMSRYRFFIVSFAAMFVWFWIPNYLFKGLSLFNWPTWVAPGSVTLAILAGSTCGLGLINPLPTLDWNIVTTLGDPIVTPLFTLLNFAAGFAIAGFIMAPIMYFANVLNTGYLPINDNKVYNNSGQFYEVTKVLNPDLTLNEEAYRAYSVPYLSATQILHMGASFTVYVAVPLHVALWFRRDIAAGVRSAWNRSSREDEFDDIHNRLMSAYPEVPYWWYGITLVTSFVLACISVTAFPTGMPIWGIVVAILFTVLLQVPIGMLAAISNVQISTSILALLIGGFALEGKVIPNMIFKMFSFMSTSQSLHFVADLKLAHYAKIPPRWAFAAQIYATLLSGFIALGVNHWSLRNIEDVCAEGQPERFTCPHTHSFFVNTVLWGAIGPRRLFGPEGPYRALLYVLPLGIVLPIISYVASRRWPNSWWRHVNVPIFIAGPVGWAPFNWSYMQGTVLLAIVFNYFVKRRYEAWWTKYAYVLTASFSAATGVAAFVIFFALQRWDIKLDWIGNTIAGAGVDQGGFMSNGTKVQCVNLPLAPEQTFASGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2024-05-29" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJH3</accession>
    <name>A0A367LJH3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7051</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJH3"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="67" mass="7696" checksum="52C246AF4B6C54AA" modified="2018-11-07" version="1">MGSLTRDTFILSTSFFTAFLFTFRPTNYFIRTQLDPLFLKKFPLSATIGNDQKYSFAKLSGSGNYTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LK19</accession>
    <name>A0A367LK19_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7079</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LK19"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="182" mass="20742" checksum="5279B5A8AC54A714" modified="2018-11-07" version="1">MIWVSGPSSSCSLIRANASSDLFLIGIVIAARELGKSDFLSIRHDFSIRKNMGKKAVEEEEGSKKLVEIIKVWITIEEELKAGEVIVGKPPSFIDKFLNNKGDLEEDFNVGRYDRYWYSASIAVTITYSAPIDVQRADRCDDRCNESIGRYDRYSPTVTQGVWPYRLISYPFKMKKYALYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LK57</accession>
    <name>A0A367LK57_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Protein-S-isoprenylcysteine O-methyltransferase</fullName>
            <ecNumber evidence="3 10">2.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_6415</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine + S-adenosyl-L-methionine = [protein]-C-terminal S-[(2E,6E)-farnesyl]-L-cysteine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:21672"/>
            <dbReference type="Rhea" id="RHEA-COMP:12125"/>
            <dbReference type="Rhea" id="RHEA-COMP:12126"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90510"/>
            <dbReference type="ChEBI" id="CHEBI:90511"/>
            <dbReference type="EC" id="2.1.1.100"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endoplasmic reticulum membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.100" evidence="3 10"/>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LK57"/>
    <dbReference type="STRING" id="1330021.A0A367LK57"/>
    <dbReference type="OrthoDB" id="422086at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004671">
        <property type="term" value="F:protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007269">
        <property type="entry name" value="ICMT_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025770">
        <property type="entry name" value="PPMT_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714">
        <property type="entry name" value="PROTEIN-S ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12714:SF9">
        <property type="entry name" value="PROTEIN-S-ISOPRENYLCYSTEINE O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04140">
        <property type="entry name" value="ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51564">
        <property type="entry name" value="SAM_ICMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="197"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI14642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="259" mass="29061" checksum="C08D37818C5254DC" modified="2018-11-07" version="1">METTDQRNSPSAFLPWEDENYPKSFYPGQPSSLSGIALRAFSLGISLATGSLVTISILIFSESPLWRVPFFLVPLSAFHFLEFWTTAEANTSRANVDSFLLTANWPSYAVAHSAAFAEAAVVGFLFPRRDWAPFHLGSFLVALGFVLIVLGQAVRSVAMLQAGASFNHRVQTRKAGSHKLVTSGIYAVLRHPSYFGFFYWSLGTQLVLGNVVCFAAYAAVLWNFFRVRIGMEESKLVEFFQDDYVQYRRRVRTMLPFIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LK62</accession>
    <name>A0A367LK62_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_6498</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LK62"/>
    <dbReference type="STRING" id="1330021.A0A367LK62"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000001">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF4">
        <property type="entry name" value="ARGININE PERMEASE CAN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="459"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="489"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="51"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI14811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="524" mass="56645" checksum="2867CE8BCD52E884" modified="2018-11-07" version="1">MSSEKQPDLLTTGQQQNPHHQDSSSSSSSVIHHNNTSHADNGLDRRLTARHLQFIAIGGTIGTGLFLGIGPALAHAGPASLLLAFVLIAAVSFSVMTALAEMAAYMPVTGAFTVYASRFIDPSLGFAMGWILLISWSLTLAVELVAAGLIIQYWNAGLNVGIWIAVFLVLFTAVNLLPIRWFGELEMWFSLIKVVFIVGFVIFAACFNAGAAGGNEGYIGFRYWQPNSPGAFAEHLVSGPAGSFVGFWVALITAGFTYQGTELVAIGAGETRDPAKEIPSAIRWTFYGIVTLFLATVLFVGIDVPFDHPGLSSSEAQDASASPLVIIANLAEKGALSHLINAVLLTAVLSAANSDIYSSSRIMIALADEGHAPAWVRRTNAHGTPYWAVLFCSSFGLLGFLNLSSDGVTVFEWLLKITAVAGFVTWALINLCHLRFMSVLRLRRQPRESLPYKAPFQPWLSIFGLVLNIAVLLTSGFTVFIQWSTVEFFASYISIFIFLILLVGHKLICRTRPIKIADVILPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKC4</accession>
    <name>A0A367LKC4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_7047</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKC4"/>
    <dbReference type="STRING" id="1330021.A0A367LKC4"/>
    <dbReference type="OrthoDB" id="10266980at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050846">
        <property type="entry name" value="TLCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439">
        <property type="entry name" value="CT120 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439:SF0">
        <property type="entry name" value="TOPOISOMERASE I DAMAGE AFFECTED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="8">
        <location>
            <begin position="69"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="300"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI14874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="332" mass="37571" checksum="0274CF545F923FD5" modified="2018-11-07" version="1">MRDPFFIAPIPWLSELARPLCELLNLPSLPLHIHEVLAAAFFYSLIFYPVSPVLSSLLAPRHYAELPRKKRLSWDAHVVSMIQSTLINVLAAWVIFADDERRLMSWEERVWGYTGAAGMIQALAAGYFVWDLAVTCRNIDVFGLGTLAHALAALLVYFLGFQRPFVNYYGCVFILWELSTPFLNIHWFMDKTNMTGSRAQLYNGYILLFTFFSCRLVYGTCQSVLAFRDIWAAVNITPNAISRESAVMVFANDTSVIPHWLAVIYLASNLTLNSLNFYWFIMMIKAVRKRFQPSARQGRPLIRDGISSTTGLSSGHKPRRTARGGTGHSTIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKK2</accession>
    <name>A0A367LKK2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">GPN-loop GTPase 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_6767</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKK2"/>
    <dbReference type="STRING" id="1330021.A0A367LKK2"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17872">
        <property type="entry name" value="GPN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000552">
        <property type="entry name" value="GPN-loop GTPase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030228">
        <property type="entry name" value="Gpn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF7">
        <property type="entry name" value="GPN-LOOP GTPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI14954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="290" mass="32455" checksum="95FEABB278F9B8A4" modified="2018-11-07" version="1">MSKFGLMSTFCAALITHLQLNRRSAFYVNLDPAAESFEHQPDLDIKELICLDDAMTEVGLGPNGGLIYCFEFLLENLDWLTEALDSLTEEYLIIFDMPGQIELYTHIPILPTLIRFLSQPGALDIRTAALYLLEATFVVDRAKFFAGTLSAMSAMLMLEVPHINILSKMDLVKGQVRKKDLKRFLTPDLGLLDDDPARGSRSLSATAQGNDDRAARPDDKDQIIKGKSFQRLNRAVAGLIESFGMVNYLTLDLTDEESIGAILSYVDECIQFHEAQDPKEPRDDEAEDQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKQ9</accession>
    <name>A0A367LKQ9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription factor Pcc1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_6840</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTAG/PCC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKQ9"/>
    <dbReference type="OrthoDB" id="10025739at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000005">
        <property type="entry name" value="L antigen family member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015419">
        <property type="entry name" value="CTAG/Pcc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283">
        <property type="entry name" value="EKC/KEOPS COMPLEX SUBUNIT PCC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31283:SF5">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT LAGE3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09341">
        <property type="entry name" value="Pcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI14967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="108" mass="11800" checksum="F03B305282B2873A" modified="2018-11-07" version="1">MTDNEIDKPELFPYSLCLRIPLPSSRLAATAFGALKVDAELSPLVSRRLSVVDDSVLLVDYSATTNRMLRVAVNSFLDNVKLVLDVMEHLDVDVFSSSSSSSSRGIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LL26</accession>
    <name>A0A367LL26_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_6630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LL26"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI15111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="494" mass="54447" checksum="C96A8BE0D02E2CDE" modified="2018-11-07" version="1" fragment="single">MEGGVGVVSLEMLLSLYSADGWMSSVGACRLQAEAIWKGRESAVSSRPIFTHQAKEAGTNGYSGADFCSPNSIPITIVTVIVTVIVTVTVITIINRHVYGYTDTNVINQLSSISRFLSEESSSRFPPLIMIDHQAPPFPSKNCRTPSFSSTTTDTFHDGTMEARHRLGEMRRINSPLYARPVHSETTDPRSPANLQVPGCMKQDRQYQLSLRCRMACITSATNVRSPATNPAPRASGRFMRGMPSRAPLIRMVSMSVILMPDISPKATLPSFSTADARPLRPPLSPVERQASRPHCSQRALNPIGRSSCRLTWHTFRLDSGPAKGDTLGQKRELTSCVDYDNVAIDMSNTDTTYPLRLLLLHQSSVSTLLRPDVEKRPRSRLRQQRPFNENGRLQTSDGIFRAPEAADASPPTRLRDATRTASRPAATVHATSPPPHRSPRPVASGKGQTGNAAQAGGSYRTRADKEQFRDEDGKKRRETTQILTMYKLDAVQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LL61</accession>
    <name>A0A367LL61_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L249_6795</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LL61"/>
    <dbReference type="STRING" id="1330021.A0A367LL61"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034458">
        <property type="term" value="F:3'-5' RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001922">
        <property type="entry name" value="DEAH (Asp-Glu-Ala-His) box polypeptide 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2130:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000018">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase prp16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF91">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE PRP16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="152"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="584"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="584"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="627"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCI15149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="636" mass="72088" checksum="22046E29BA39E082" modified="2018-11-07" version="1">MIGCTQPRRVAAMSVAKRVAEEMEVKLGGTVGYAIRFEDCTSKETIIKYMTDGVLLRESLNEPDLDRYSCIIMDEAHERALNTDILMGLFKKIIQRRRDLKLIVTSATMNAKRFSDFFGGAPDFTIPGRTFPVDVMFHRSPVEDYVDQAVQQVLAIHVSMDAGDILVFMTGQEDIEITCELLSILPIYSQMPADLQAKIFDRAAPGVRKCIVATNIAETSLTVDGIKYVVDAGYSKLKVYNPKMGMDTLQITPISQANSSQRSGRAGRTGPGKAFRLYTDKAFKEELYPQTIPEIQRTNLSNTVLMLKSLGVKDLLDFDFMDPPPQDTISTSMFDLWALGALDNLGELTELGRKMSAFPMDPSLAKLLITSEEEGCSEEMMTIVSMLSVPNVFYRPKERQDEADAQREKFWVHESDHLTYLQVYSAWKSNGYSDGWCIKHFLHAKSLRRAKEIREQLLDIVRMQKMQLRSCGMDWDMIRRCVCSGYYHQAAKYRGSGEYINLRTNVAVQLHPTSALYAGHPPDYVVYHELVLTSKVYVSTVTAVDPHWLADLGGVFYSVREKGYSAREKRTTETEFNRRMEIETKMADDKRRQEERLRTEAERATAKPRGDDGGGRKFVTQGAVKKPVVRRRGRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LL70</accession>
    <name>A0A367LL70_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytoskeleton-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_6944</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LL70"/>
    <dbReference type="STRING" id="1330021.A0A367LL70"/>
    <dbReference type="OrthoDB" id="5385189at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI15186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="348" mass="40248" checksum="5F7AA2FC85708C8A" modified="2018-11-07" version="1">MAWKDGFWAVACDERLILLSIGLAAFGIVSSIYQTLTFIRDQNEMPPTEPKTQYITQDTEDALKLETLEKLLHHPSFSIREVSTKILCDRAVNDPETMTYLLYGITRPDYEERMQCLRALAMLTGQTMGRDANPADMLSFPADRGTMLGLEGLSRLNNEKAMSALVRCLELSLEDVEPPDLSNSHWDEYYLRDMAERFCLMFVLELVNKYGAGLLIKANFVERWLAKQKWGDDTKERRRRFKEYMEFKTNRIVDIVSSIKHSKRGLRALEKASLIEKANSRRHMRELPDLVMEEEAVVVGDQLARRAREHSAEERRLRRQHREAMVLNDGTRPLGRQDIIEREHGSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLX8</accession>
    <name>A0A367LLX8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_3465</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLX8"/>
    <dbReference type="STRING" id="1330021.A0A367LLX8"/>
    <dbReference type="OrthoDB" id="3437960at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000557">
        <property type="entry name" value="zinc finger and SCAN domain-containing protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF139">
        <property type="entry name" value="PAIR-RULE PROTEIN ODD-PAIRED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="368"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="409"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="441"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="469"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="499"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="527"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="294"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="313"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI15428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="604" mass="66786" checksum="5780314114BF1A12" modified="2018-11-07" version="1">MDPHSAFHGHVDHNVTPTSMIDYHALVVPDDDDHYRDMQTTDMLRHQRQHHPPPSLPWPPAFDLGAPPALQPPVCLPLCGQGDGDDDDDCASDCSATCDRPCASQCGDVVCCDDDACESSELCRDEACQDRPCMDENCRTDRDDAAAAAVLTSFGDNSQLPMMSYADHTLQQFMPCASLSTMLTLPDGSSCFPNQPCNMTMEYALANHIAQYHDPSYGLAHANKCVANDPAQVMPRCTLPKMSLEDNQYLSSLSASECGFQVQDPSAFADHIFEDHLPVLEYHQAAVTLPAITRPPPAPPPPHMIHHDQQHFSPSSSPLTTLSGGPALSATPSSLTSFAAPSPLESIATRSLSPPAAGSVALAQEDQFTCRWIDQHGSICGRRFDNDEQLQKHCKLDHLKPLRKARVGFRCGWANCTRSTSFSQRSKLERHMQVHTGYKPVHCDVCGAALSAKQALEQHKRIHTGETPWLCKFPDCGCAFKQQSALTMHERTHTGLKPLKCEICFKRFSESSNLSKHRRTHNVKGLHECKICGKDFHRLDQLRRHVSTNHKDQHAELDALFGRAKPRYQATLKVTKPIKTVASKTVLQPLDSGAPVDQMLKWRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLX9</accession>
    <name>A0A367LLX9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phenylalanine--tRNA ligase alpha subunit</fullName>
            <ecNumber evidence="5">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">L249_3407</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="5"/>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLX9"/>
    <dbReference type="STRING" id="1330021.A0A367LLX9"/>
    <dbReference type="OrthoDB" id="238316at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2330:FF:000002">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000028">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040725">
        <property type="entry name" value="PheRS_DBD3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003210">
        <property type="entry name" value="PRK04172.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF40">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18553">
        <property type="entry name" value="PheRS_DBD3"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
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    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="17">
        <location>
            <begin position="223"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030612"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
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    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RCI15434.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="498" mass="55940" checksum="E64E4235C753BE62" modified="2018-11-07" version="1">MPASLPEQILQALAEKSPLASAEAFPDTPFQELKSALDRLGSRSMITYEPIEREEALLEAEAEQIAAHGSHEARVFEALKKAMNGLTVQELEAAIGDKNVTKLGQGKAFREKWISKSKDGKLIANADSVQDTTRAALQKIKESRTGDGKVLSDLKKRKLIRMQKVITFRIAKGPKFGLEMPKEETDLTADMLASGGWKTATFKPYNFKALGADQDAGALHPLNKVRHEFRQIFFEMGFEEMATNKYVETGFWNFDALFVPQQHPARDLQDTFYISDPKVAGKPGAEEYWDNVKEVHEEGKYGSIGYRYAWCADEALKLVLRTHTTSISAAMLHRLASTRGPDGRPAPARYFSIDRVFRNETVDATHLAEFHQVEGVIADYGLSLGGLMEFMQVFFGKMGISDLRFKPAYNPYTEPSMEVFSYHAGLKKLVEIGNSGMFRPEMLEAMGLPREMRVFGWGLSLERPTMIKYGISNIRELLGHKVDLAFIERNPAVRLEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LM56</accession>
    <name>A0A367LM56_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L249_3576</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LM56"/>
    <dbReference type="OrthoDB" id="10266508at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071474">
        <property type="term" value="P:cellular hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06225">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000002">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1530:FF:000001">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1530:FF:000002">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000015">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000207">
        <property type="entry name" value="Two-component osmosensing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1530">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003660">
        <property type="entry name" value="HAMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45339:SF1">
        <property type="entry name" value="HYBRID SIGNAL TRANSDUCTION HISTIDINE KINASE J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00672">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18947">
        <property type="entry name" value="HAMP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00304">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158472">
        <property type="entry name" value="HAMP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58104">
        <property type="entry name" value="Methyl-accepting chemotaxis protein (MCP) signaling domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50885">
        <property type="entry name" value="HAMP"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="HAMP" evidence="15">
        <location>
            <begin position="171"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="15">
        <location>
            <begin position="287"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="15">
        <location>
            <begin position="379"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="15">
        <location>
            <begin position="471"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="15">
        <location>
            <begin position="563"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="HAMP" evidence="15">
        <location>
            <begin position="655"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="13">
        <location>
            <begin position="729"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="14">
        <location>
            <begin position="1102"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1240"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="109"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1242"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1288"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="10">
        <location>
            <position position="1151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCI15480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1304" mass="142664" checksum="17AF5EC68866E5F9" modified="2018-11-07" version="1">MADEAALAAAAEVVASLAADQPSSSSLAVGLGAPIKLPGRDSPSKRILEMELQKLALRIDQLENRASVSGPAILPETPSEVNDSLFGHENGHARTTPCKPRLSHAHQALEGLREHVDDQSKLLDSQRRELAGVNAQLLEQKELQERALEVLEQERVATLERELWKHQKANEAFQKALREIGEIVTAVARGDLTMKVRMNTVEMDPEITTFKRTINAMMDQLQIFASEVSRVAREVGTEGLLGGQARIGGVDGTWKELTDNGTNPCLLVHVQGDADFLDRPAVNVMAQNLTDQVREIASVTTAVAHGDLTQKIERPARGEILQLQQTINTMVDQLRTFASEVTRVARDVGTEGMLGGQADVGGVQGMWNDLTVNVNAMANNLTTQVRDIIKVTTAVAKGDLTQKVQADCRGEIFELKSTINSMVDQLQQFAREVTKIAREVGTEGRLGGQATVHDVEGTWRDLTENVNGMAMNLTTQVREIAKVTTAVAKGDLTKKIGVEVKGEILELKNTINQMVDRLGTFAVEVSKVAREVGTEGTLGGQAQVANVEGKWKDLTENVNTMASNLTVQVRSISAVTQAIANGDMSQTIDVEANGEIQVLKETINNMVGRLSSFCYEVQRVAKDVGVDGKMGAQADIAGLDGRWKEITTDVNTMASNLTTQVRAFSDITNLATDGDFTKLVDVEASGEMDELKRKINQMISNLRDSIQRNTQAREAAELANKTKSEFLANMSHEIRTPMNGIIGMTQLTLDTDLTQYQREMLNIVNNLANSLLTIIDDILDLSKIEARRMVIEEIPYTLRGTVFNALKTLAVKANEKFLDLTYKVDSSVPDHVIGDSFRLRQIILNLVGNAIKFTEHGEVSLTIKEWADQEDVRPGEYAVEFVVEDTGIGIAQDKLNLIFDTFQQADGSMTRKFGGTGLGLSISKRLVNLMGGDLWVNSEAGKGSQFHFTCRVKLATGDTEAIKKQLHPYLGHQVLFVDKAQSSSGPDIRAMLEQIGLQPVVVDSEMSSALARVNAGGALPYDAILVDTIDTARRLRAVDDFKYLPIVLLAPVVHVSLKSCLDLGITSYMTTPCKLIDLGNGMIPALENRATPSLADNTKSFEILLAEDNTVNQRLAVKILEKYHHVVTVVSNGWEAVEAVKAKKFDVILMDVQMPIMGGFEATGKIREYERSVGTHRTPIIALTAHAMMGDREKCIQAQMDEYLSKPLQQNHLIQTILKCATLGGPLLEKNRERELAIQADAKSSSHNHNAQGFLRPSLESRAFTSREPLTGTGLASPALVTAEEEDPWARARRDLSDMRSISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMB3</accession>
    <name>A0A367LMB3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_3612</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DOP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LMB3"/>
    <dbReference type="OrthoDB" id="297643at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.210.10">
        <property type="entry name" value="Heat-Labile Enterotoxin, subunit A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040314">
        <property type="entry name" value="DOP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056457">
        <property type="entry name" value="DOP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007249">
        <property type="entry name" value="DOP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056459">
        <property type="entry name" value="TPR_DOP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056458">
        <property type="entry name" value="TPR_DOP1_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042">
        <property type="entry name" value="DOPEY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042:SF24">
        <property type="entry name" value="PROTEIN DOPEY-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24598">
        <property type="entry name" value="DOP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04118">
        <property type="entry name" value="Dopey_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24601">
        <property type="entry name" value="TPR_DOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24597">
        <property type="entry name" value="TPR_DOP1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DOP1 N-terminal" evidence="8">
        <location>
            <begin position="40"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like middle TPR" evidence="9">
        <location>
            <begin position="395"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like TPR" evidence="11">
        <location>
            <begin position="995"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like C-terminal" evidence="10">
        <location>
            <begin position="1333"/>
            <end position="1802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1015"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1422"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1742"/>
            <end position="1761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2189"/>
            <end position="2286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1021"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1039"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2189"/>
            <end position="2204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="2209"/>
            <end position="2235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00046326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF24598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI15549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="2645" mass="292770" checksum="91B55A6834A76C93" modified="2018-11-07" version="1">MALEPASGVYSASPESSGRDSPVPRGWRNQLGQDEPPVRDKAYRKYVANVEKVLSQFETTLEEWADYISFLNRLLKSLQARPTSAAAIPAKAIVAKRLSQCLNPALPSGVHQKALEVYNYVFSVIGKDGLSQNIPLYLPGLAPTLSFASLSVRAPFLDILENHVLGADPRSLRPATKSIILALLPGLEDETSEDFDRTLNLVTSFKKAIRPPDSQPIDQHHSSGDAFFWQCFFLASITGHGRRSGALAYLNQSLPVLAPVPSIGPAVATTQDDVDEGSKMALIVTSPEPGLLVRCFASGLTDDQLLIQRGFLDLLVSHLPLNSAVLQSRVKPADLKLLVEAAAGVVTRRDMSLNRRLWAWLLGPEPVANEADSVGDPATPSREQHQASLSPRTSYFEEFGLQPLTKALLDMIRGAASGTAAERARPYRMCLSLMDKWEIGGLVVPEVFLPVVESVRQYQSRAPAKADFAEVLRSASVFFDGIESGLIFSEIFRLLAQALGVEGINMDDRVDKISLVGFIVANFNVREEEMVTIHGPLTCLAALSMLEHLQARAVRTGLTASQLVKLSEKALNVIVSLVELVPDRAFPAVRAEAASPPSDSNADILKRVKTFYLDEHGNLDSSQPPFDPVQCGELLLQKAVKYTCDDNGEDNNSGSYEDLGLRVRIFTLMLLKTPTSYKFDVDRTMAHLQAQLQQTCPLPFSHLSSVLHLATQLYSADRIDATQLSEMVSPLVCHAWSYLAASDPKYHVETVRCLWQLQTALTPWDREIEAALSGILVESQSTGPCVGTFAEAARTFGVLWSHTLQDTAGDRRGPRTPMQEYRPTLRLSGMEHYPVMLTQPLFLVLDALLDERTQAYMVVKSWLNNAIGMDRLFLLFVDKLHEMPFLSSVGIAVSDGNKEPVLFNQDDDLDLWSAEEGEMTLQDYFIRACAECVTGEIAADADEVLAGQVSQLRRYALIILHQFLSSRHAPPVAQHQLDKVFLDRLAKSISTPDPYVQVLLLDVILDTLKLQDTAQGERPATATSERMSSMTDRARGGRTSVSVSENSHSGPQMPPQLLKCLQAGLSCPSSHSVLDSWISFLGDCLPFFSHSIFQVLIPLVETLCRQIGTTLSDLRNTFLAEPQPTGGGGSAPESALFYLLNGLERVLALAHDQLLTQETRARLLKGPEQTQSLLGSMVSGVFQSENAHSRSATANDRLTVHLAFQDTMRTCYKIWSWGQGDEAKKQDPASLASFNYTSLRMRNRARRLLEHLFAAETLECLETVIGIWRSAAASAAERAQVFHFLSALDACRPRHCVPALFNSIYSRTNPSALDPSRKSAMTISLQDLDLVVFLVEYARSLEDDAMDEIWADCMTFLRDLLGNPFPHRQTLPSLLEFAGILGEKVDNTNFGEQRRMRRELSDIFLRLLAALFTTRPMTFADANGSTEKLSNSNRRRTMSSSGDGSEDVVRVLASIVPKLPQILLENDRVVSAAATISTNVIGPALRSRGFPDTFSPSVIRLLLELSRLHNGQKAWKKDVAEAFNDGRFLGTKAQVVEDEWLPLLRQWVLADKERMGEIVGRISAPTTAGIVFGVGATSARLEADRRTQLNLRRMATLVLASADDAFVADLTVVMDKLVELLAATATSSPSSTTRADVFQVVRALVLKTKPVHLAALWPVINGEMHAAMSSVAAAENSVAAETYGPTAILQACKLLDLLVCVAPDDFQLHEWLFVTDTIDAVYRPATYQPVALVDELADELGGGGETEAASTSADPLAGERRRRRPLLGETNVVAEGKEDLVTRVLRPFFGQLSIFAFESTYAMGVVDREACVRGLLRDVFDERTVSLLLWQVAFAVDDHAGDNDGRPHRGDDNPLMFQVLDGSVRPLYVVLYGQQFAPSRMRSLGRLWSGIFDWDIWSRDRDGARYLLTEQPLINPRRNEQSGAWVYVVTSSPNLGLLNRNPTEGYEGGRFLPFGGVPWSQVRSYAYLPAGWVGLLPHEWLVPWLGNNDWAMHPDNIAEHMVENAQYDERWDRFGLATVNIAIADRADRRNYLRHGRNQRRLIDSLTTHGNLVRESDPEIEGEEPRMESIPEDEVAVLRNLFHWDPTNTSRSFPLGEPGQPESLRSRSLRSLSLDNLDLEPPALRTRLASGIAQGFHCEEVFREINAEEERRKRRNRCTLLRKRQDQPQQHDRCDDLVQLMEKCPILLDKIDGGGRHNDTETKSVSKPKPTKAKKPKAKKPKAKKPKSRSKKTSKSKQPSRADGNKIQRPAVKPASHHNSTTPKPTAKKQRPPHVNGTRVQVEAESQCKGGHDYKGVLKGMTTAELDELDVVLQRNHPSEFRTVALFALCGPLFVINSKPKLAKRHASLLSTEERAMCIKVKNKACVKDEKKQKQQQPLKYIFYASHEWPSVVEQMGGFLPEGTDRHQFFLGDNNAFLDFGEAAERAAAHPPKDESMPEQAGVVYYVHATPNMLIPDDGRNITIVGGIVWSQVRGWLQIKAGYRRSPPHQEASDKTAALHGVHKAAQANLTILTPNKKYDVRFDSLTATPDVMPTTLRFIRSSASLLREEATRFMDEKGKPVGWKGDFPLFKKGRVAKARVKPPHHEGFWRSLWDLIEKHPYVDVLITVGVGALGFLVMGPAGAVVAVEAVDEAIPLLAIGAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMC0</accession>
    <name>A0A367LMC0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_3600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NFYB/HAP3 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMC0"/>
    <dbReference type="STRING" id="1330021.A0A367LMC0"/>
    <dbReference type="OrthoDB" id="386949at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22907">
        <property type="entry name" value="HFD_NFYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027113">
        <property type="entry name" value="Transc_fact_NFYB/HAP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003956">
        <property type="entry name" value="Transcrpt_fac_NFYB/HAP3_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064">
        <property type="entry name" value="CCAAT-BINDING TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064:SF9">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00615">
        <property type="entry name" value="CCAATSUBUNTA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00685">
        <property type="entry name" value="NFYB_HAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="6">
        <location>
            <begin position="61"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="144"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="180"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI15583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="212" mass="22766" checksum="913F98389A126682" modified="2018-11-07" version="1">MNENRDPQSAGLGGYEFDGVKEQDRWLPIANASHASMSHDSSRISRTDKADELDANIRNFAPVARIMKNALPDNAKIAKEAKECMQECVSEFISFVTSEASEKCQQEKRKTVNGEDILFAMTSLGFENYSEALKVYLSKYREQQNQSNRERGGDAGYMGPMIPGEKGEPASAGGEYAVPGGEASSGADGGADASYMYGSHAAHNGAGAGEGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMF0</accession>
    <name>A0A367LMF0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMF0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016784795" evidence="1">
        <location>
            <begin position="22"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="66" mass="7130" checksum="562AB1E22055A770" modified="2018-11-07" version="1">MKTTPTLHLLFLLLFTTPITARWVFDKRSSCQLCAVGPLNGGDACCSASCAAQHKDIHGGHCNDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMZ9</accession>
    <name>A0A367LMZ9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_3356</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMZ9"/>
    <dbReference type="STRING" id="1330021.A0A367LMZ9"/>
    <dbReference type="OrthoDB" id="18894at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="235"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="372"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="409"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="447"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="476"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="504"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="10">
        <location>
            <begin position="207"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="534"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="135"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="150"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="543"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI15622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="606" mass="66425" checksum="C01088A3DC9F777E" modified="2018-11-07" version="1">MPSSRPAISSPLSSPSSASASAPPQTTTVSLARFPTLSDELSSSSSSSASSSSTSTSTTHAASSSSSSSHHHHRGDDIEMEPVVGHRRRTSSLIHPVGGHRTRLSINIPQDSDDHTHALIRSAHPSKADSATDSSGDEDDDDDDNDDDDDHHADEEMGLSRKDNRRRRRSRQRNMRLDNRIAREKVLSNDELREADHDVFRRLLVNGIFILLWYTFSLSISLYNKWMFDRDRLNFAFPLFSTSMHMLVQFVLAGLVLYFVPSLRPQSMHNSDGGRSRHETEPTSSVMSKMFYLTRIGPCGAATGLDIGLGNASLKFISLTFYTMCKSSSLAFVLLFAFLFRLETPTWRLVAIIAIMTMGVILMVFGEVQFKLGGFVLVISAAFFSGFRWGLTQILLLRNPATSNPFSSIFFLSPVMFVTLLFLAIPVEGFGPLWEGLKTLSAEWGVVMTPLFLLFPGCIAFLMTASEFALLQRTSVVTLSIAGIFKEVVTISAASVVFQDHLTFINIVGLLTTMAAIVAYNYLKITKMRRDAQVNVHGRHSESSPLSPSSAAGSPSDLDADDEADESTRLSRPSPAATPHLGPALVTSDGDIQPNLLPARVRGEQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LN99</accession>
    <name>A0A367LN99_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_2715</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LN99"/>
    <dbReference type="STRING" id="1330021.A0A367LN99"/>
    <dbReference type="OrthoDB" id="10018191at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF10">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI15880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="69" mass="8400" checksum="7BCD519C37FEE7E0" modified="2018-11-07" version="1">MFPNHHAPEGKPQPGPPRRRDQNQKNLPCRFCPRRFRRVEHVQRHERTHTKEKPFPCNWCGCGKRFARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNV4</accession>
    <name>A0A367LNV4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNV4"/>
    <dbReference type="OrthoDB" id="5375886at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="65" mass="6885" checksum="19B2EA0D8F36BAF3" modified="2018-11-07" version="1">MDKNDNNNNHSESPPPERQSGAQLHEPPASGQGIVDKSEKAGGDQVKGLSSNPQGSDEVVKQKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPA9</accession>
    <name>A0A367LPA9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="19">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">L249_2174</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 19">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38567"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:38568"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="19"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LPA9"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090556">
        <property type="term" value="F:phosphatidylserine floppase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000026">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000047">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000010">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF150">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 17 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 18 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 17 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 19" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="501"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="555"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1070"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1109"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1151"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1189"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1217"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1256"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="21">
        <location>
            <begin position="238"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="22">
        <location>
            <begin position="1038"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="124"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="184"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="186"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="16">
        <location>
            <position position="619"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="619"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="619"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="620"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="621"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="621"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="714"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="755"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="778"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="811"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="892"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="893"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="894"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="985"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="991"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="1012"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="1015"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="1016"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="1016"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="RCI16276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1368" mass="152189" checksum="9C684A9D4969F9CA" modified="2018-11-07" version="1">MAGPPSRHGHGGSSLKREDLLLDLDSDQPAYNDGQRSTLNDDDLLRVHTLDDDVPSPRRPSVSYDDFVGASGPSPGPSPLTPHHPGSGPYLHKHYSQTSDLNNYQRYVDDLDEYPADAESYYHRASSAPGQPLATSASARNKARNRNSVLGLGGGLLGRVKNKLGMGEGYSEMDLPLTEPGQERLAAASNSSHNKAGGNNSSSNSGSNNNNNKFDMGNFKFGFGRSKPDPSTLGPRLIHLNNPPANAANKYVDNHISTAKYNFATFLPKFLLEQFSKFANVFFLFTAGLQQIPGLSPTNRYTTIAPLLIVLFISAGKELVEDYRRKQADNALNTSKARVLRGSSFNETKWINVGVGDVIRVQSEEPFPADLVLLASSEPDGLCYIETANLDGETNLKIKQALPETSAMVSPSELSRLGGRIKSEQPNSSLYTYEATLTMQAGGGEKELALNPEQLLLRGATLRNTPWIHGVVVFTGHETKLMRNATAAPIKRTKVERQLNWLVLVLVGTLLALSVICTVGDLVLRSVQGDSLEYLYLDRINSAGKVARTFARDMVTYWVLFSSLVPISLFVTVELVKYWHGILINDDLDMYHDKTDTPATCRTSSLVEELGMVEYVFSDKTGTLTCNQMAFKQCTIAGVQYADEVPEDRRASSADDDADGVMYDFGRLRDNLAGGHETAAAIDHFLTLLAICHTVIPEMTDQGQVKYQAASPDEGALVSGAVDLGYRFTARKPRSVIIEAGGRTLEYELLAVCEFNSSRKRMSAIYRCPDGKIRCYCKGADTVVLERLNDKNPHVEATLRHLEEYASEGLRTLCLAMREITEQEFDEWYRVFDAASTTVGGNRAEELDKAAEVIEHDLFLLGATAIEDRLQDGVPETIHTLQQANIKVWVLTGDRQETAINIGMSCKLLSEDMMLLIVNEETAAATADNLRKKLEAIRTQADGSIETETLALVIDGKSLTFALERELEKTFLDLAVMCKAVICCRVSPLQKALVVKLVKKYQKESILLAIGDGANDVSMIQAAHIGVGISGMEGLQAARSADVAIAQFRYLRKLLLVHGAWSYQRVSKTILFSFYKNIALYMTQFWYTFQNVFSGQVIYESWTLSFYNVFYTVLPPLALGILDQFVSARLLDRYPQLYMMGQNNYSFRLRVFAEWIANAFYHSLILYVFSELIWSDDLVLSDGTTAGHWVWGTALYGAVLLTVLGKAALVTTNWTKYHVLAIPGSMAIWFVFIAAYGSVAPLVGLSTEYRGVVPRLFTSPVFWLQTVALATLCLLRDFSWKYGKRMYRPQTYHHIQEIQKYNIQDYRPRMEQFQKAIRKVRQVQRMRKQRGYAFSQADESQTRVLQAYDTTKNRGQYGEMASSRAPAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPD3</accession>
    <name>A0A367LPD3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_2140</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPD3"/>
    <dbReference type="STRING" id="1330021.A0A367LPD3"/>
    <dbReference type="OrthoDB" id="438641at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF273">
        <property type="entry name" value="MYND-TYPE ZINC FINGER PROTEIN SAMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="4">
        <location>
            <begin position="282"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI16270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="603" mass="66958" checksum="E3769EDC41FE81E2" modified="2018-11-07" version="1">MEDREARLEQLLDRRAQLSQGLASLPYDLMLYLERAAVHSHLGYPDLAAGDAYRALLLADEVANDAFEYHHQALEALHMRAGVHVPEVLNHGNLSSLLTPATVDCGDAEARRLAVVGSIRAYQILSLSLLLCGCLKSAYGFCIRGLDLAPENRELINTKAHIQTVARRKLRRDDVDDLHLLPDNGLVRREVYPWNDFEPDRFSPESLASLNAQLREMAPKCVVQVATLPVLLEGESETDSHDIIPTCQQLGLFARDDIAPGEPVLEEYSLLTANNRLQDPACDACGAELPPLGGEEKKSPVRCQDCHDVVFCSSYCHDEAQRCYHPAVCEKDKSPVRCQDCHDVVFCSSYCHDEAQRCYHPAVCEKDVGSIAKDPAASEADDALYLLLLARVLALAAHQAVNPLELPQVKFLWGDFVPPRSNDIDSAPNAGPPPEWTLPFSFKYNIEAPLHLLEKMDVDIFASLAEYEGWIVNTVYAKFRGTASARKNARDGRPDVAAVHPYWCLANHDCDPNVTWDWGGRMTLYARKGRVNFHGEDGEDGEDGDDSAAVRKKNPPGIKRGDEILNHYCDVSLPVQQRREWALGSLGGWCMCRRCRTEAAAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPG1</accession>
    <name>A0A367LPG1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH-ubiquinone reductase complex 1 MLRQ subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPG1"/>
    <dbReference type="OrthoDB" id="202195at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010530">
        <property type="entry name" value="B12D"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06522">
        <property type="entry name" value="B12D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="92" mass="10540" checksum="8A6D750CF9009A56" modified="2018-11-07" version="1">MRSTASLRMFRPTQRMMFRQSPRVMRPIPNEEQAGHTISQRLRKLKEIPIELIPLAVVVGAAIFAAGYSVVRKLMTDRNLRLTRTGPRDGNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPS8</accession>
    <name>A0A367LPS8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2472</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPS8"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="56" mass="6227" checksum="630A5F57DC02C0B7" modified="2018-11-07" version="1" fragment="single">MTQRGGTLIFFGARRHSGTTTTDRALKAQHSNAQRDTGRGREMIWERTHSSAGVLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQ92</accession>
    <name>A0A367LQ92_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PUM-HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_2232</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQ92"/>
    <dbReference type="STRING" id="1330021.A0A367LQ92"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010608">
        <property type="term" value="P:post-transcriptional regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000237">
        <property type="entry name" value="Pumilio homolog 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF13">
        <property type="entry name" value="PUMILIO HOMOLOGY DOMAIN FAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="5">
        <location>
            <begin position="584"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="610"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="646"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="682"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="719"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="755"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="791"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="827"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="3">
        <location>
            <begin position="863"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="144"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="339"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="444"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="926"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="989"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="930"/>
            <end position="947"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI16606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1009" mass="111012" checksum="7AF3A308C4DFB375" modified="2018-11-07" version="1">MDELRFRSQQSPRNETPMTAYVSPPRNGSRLPQQPSHDPRSNMPRRFTTDSGRVPTMPSASPPQRVDAAQDYTTLHKVQLVGHLLPSRQRLSTTHSNVVPCSRTATVEDLTEVLQIEQKKIEYERIREQRRRFELEMQRLDQQQRREAQELAQMEEEMGRIGGHQSEPTTPPECHDNSGFPSIFSRPNRYSTSSIASPPGLYGRPSRSGSQLTSPPAGLVQHRYGDDDDKEEAVRQDPTSHRSTNALNRYSMPVTRSRNGLYDMNLDQTNTTRFLFGDDEPKALPQGQAPDESFPTLVRREDQMLSASSAALDLALSPSPKPEPPGPNGWNRVDRHRTQQSLSSVNGSSPNQNSELASPGSRPASIGTSLDLKYLAGNATEAAAGLLSSQSHSNMAATPPRLQSSFSANDVPTMKNTAGPAMMGSNANSHAQQHFHNHNVSIGRIPAGALPTRGHNRELSGDNGAAGGRDQGNSYPSIQSALQASAPPFGPGLNSPSPMMPAAAVASPASTAGINQFHAAFYPASNYTAMGANAATSNFSMPLLTAGMQQMSANGVNGGAIYSPQNYTGFGSIPFSQSAQSRDSQARVIQSRRQLDSEAMSRYNNMPLESFRGQIYELCKDQHGCRYLQKKLEERNAEQVKVILLETKQHVTELMMDPFGNYLCQKLLEYCNDDERTVLIQNASQDMVRIALNQHGTRALQKMIEFVSTAQQVRLIIEALRFRVVELIQDLNGNHVIQKCLNKLVANDAQFIFDAVGSNCVDVGTHRHGCCVLQRCIDHASGHQKAWLVERITDHARVLVQDPFGNYVVQYIIDLNEPSFTDPVVQSFKGCIGSLSRHKFSSNVVEKCLRCAGPESRDLIVDELLAPQEIERHLRDSFGNYVIQTAVEFATPHQKYRLVEAIRPLLPQIRNTPYGRRIQAKIAQYDNRGSAASSGQTTPADNTQGQISIRPGHARAMSNSGGRQNVAVYGGNAVPQGHFQQTQYSQVAPANYSPAHPGNSAAEGEPQWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQF8</accession>
    <name>A0A367LQF8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_2689</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQF8"/>
    <dbReference type="STRING" id="1330021.A0A367LQF8"/>
    <dbReference type="OrthoDB" id="447251at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429:SF7">
        <property type="entry name" value="GATA-FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429">
        <property type="entry name" value="PROTEIN TWIN LOV 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0157">Chromophore</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAS" evidence="4">
        <location>
            <begin position="96"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI16685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="195" mass="21530" checksum="A552C4E53D7A682E" modified="2018-11-07" version="1">MASASEVSQPPLNPWESRALDHRFAVPLPVAVASSSRRQPRSDPLIYPGLYSASGFDLMNLLFRIISRPNPQIELGAVDCSVALVVCDLQVPDCPIVYASDSFCEMTGYSKAEVLGRNCRFLQYSAHHPSGPPSAKTTVAAQQIRQAMESGREVQVMLQNYKKNGQLFNNFLSIIPVEMNSRGHRYAVGFQVQVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQN8</accession>
    <name>A0A367LQN8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_3291</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQN8"/>
    <dbReference type="OrthoDB" id="3497560at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI16660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="219" mass="24154" checksum="6473DA6ABA864E2B" modified="2018-11-07" version="1">MATVISTTIIQESLKASTRLHNEYALDTAMPQVDLSSDGVSEVARIIIKFGYRNLMRLRLLHRHLDLPEGYILLEKSIPGGYWIEPTPVQKIDLGQTCGQIFSVYRGGLLPTEFRCGPSNLALDAKFSMELAKALLQNNLDAILGIEVVRDGKRCKMIETSDDSGSLLRDEATVTLTNRETLQGTAWAVTGDGVVDQAAEVRCVVLEGTHRRVTPKPMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQY6</accession>
    <name>A0A367LQY6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GDP/GTP exchange factor Sec2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_1779</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQY6"/>
    <dbReference type="STRING" id="1330021.A0A367LQY6"/>
    <dbReference type="OrthoDB" id="1748564at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070319">
        <property type="term" value="C:Golgi to plasma membrane transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21044">
        <property type="entry name" value="Rab11BD_RAB3IP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040351">
        <property type="entry name" value="RAB3IL/RAB3IP/Sec2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009449">
        <property type="entry name" value="Sec2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430">
        <property type="entry name" value="RABIN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430:SF0">
        <property type="entry name" value="SEC2P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25555">
        <property type="entry name" value="RAB3A-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06428">
        <property type="entry name" value="Sec2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144284">
        <property type="entry name" value="Sec2 N-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDP/GTP exchange factor Sec2 N-terminal" evidence="4">
        <location>
            <begin position="110"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="369"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="586"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="117"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="369"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="601"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="645"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI16866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="671" mass="72391" checksum="1091672D6B76DF03" modified="2018-11-07" version="1">MESLIHVAGWSQHQQQSSRPRSARPLGHLRSLSSVAAEPSPKTQLQPSVISSPIPLRTSNSVPVLNDEMSTLPDPRSRPVMRDDASDAHPDLDDEIAKLSAKLVNSINYQTLLDDTLTATRQELQSARQHIRELEDQLQSQRDMMAGDVWVRRSSLDNERKAMLAEKKAWQAKLADEKARRLETDHDKRKMEQELENLTTALFEEANNMVIGAKAEAQARNELLARKNDQLRAQLADSESLLKSQQEQLSQLKDVMESMASERDDLTNGTAPSSPGVCRLAAVAADDDTAVTSDAGAGAAQGPGTDNGLSPCNPTSLHYLLQPILRTDLASYDDFVALARLSDNRRGSRVSSGSLGGLTALALGLGGSTSSAHASNGSTTSLSASATSPNSSPQSPNTPASAASGASSSANTTATTSSSSSSSSSFTNLKDTRFYKRVLADDIEPTLRLDAAPGLSWLARRSVLASVTDGSLIVEPVPDSATYIAIVKPHLNPCSLCGESREEAEHLRNHRFRTSESNSAQRYPLCGYCLGRVRSTCDFLGFLRLIRDGHWRADGEDQEKAAWEESVKLREQMFWARIGGGVVPAGLVHPDRSPRSSQDVTPPATITTTTTTTTTTKTNTSNTAEEAPLAGGDGAVEEDDYVDATSEKGGEEFLRSPRTPPEQIRRKVEGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LR47</accession>
    <name>A0A367LR47_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ESCRT-II complex subunit VPS25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_2724</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LR47"/>
    <dbReference type="STRING" id="1330021.A0A367LR47"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071985">
        <property type="term" value="P:multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000141">
        <property type="entry name" value="vacuolar protein-sorting-associated protein 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.570">
        <property type="entry name" value="Winged helix' DNA-binding domain. Chain C. Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008570">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014041">
        <property type="entry name" value="ESCRT-II_cplx_Vps25-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF138">
        <property type="entry name" value="DEHYDROGENASE PKFF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05871">
        <property type="entry name" value="ESCRT-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="9">
        <location>
            <begin position="127"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="10">
        <location>
            <begin position="322"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI16899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="823" mass="92179" checksum="C855C684ED556218" modified="2018-11-07" version="1">MPQPLRNQVPAPPPDGGSIQAGPRGQWLGFLEGDIRKERVFDYVVVGGGTAGNAIAVRLAQAGFHVAIVEAGQLYEDLDGGSHVTPGFDLVGVGWSTADVVKSDVDWKFVTEPQHGSNYRRMHVARGRCLGGSSALNFMLYHRATRGSLDVWSEMVGDDSYRFDNLLPFYKRSLSFSPPRPHARKANSSAVYYVPRDFDPAGRGGGPVQIGFTNYVSAWSTWLESGLKSLGMKAENDYNYGRLNGYHYATTTIRPSDGTRSSSAAFVFEAKKQRLYNLRVFLRTQATRILFDRYKRAVAVEVYHDRAYYKLRARKEIIVSAGAYQSPQLLMVSGIGPVETLSRFRIPVVSPLAGVGQNMWDHVFFGPDYAVKFQTRDHFADHVEALVEATMLYHDTGTGPLSSNVPEFLAWEKLPPRYRTRFSPETVRELDGFPPDWPEVEYLSGDGYIGDFYSVLNNQPMDGRMYATILGALVAPLSRGNITIRSASALDPPVIFPNWLEHPADKEVAIAWFRRMRDVWTSPGLGFMTYGPEYYPGPQVQTDQQILDAVRKSLMTVWHPACTCKMGRRGDRTAVVDSQARVFGVSALRVVDASSMPILPPGHPQSTIYALAEKIADDIIREQRVPAQDPSPSSFFSSSSSSPSSPFPFPREYHFPAFFTRQTNLTTHHAQLLKWSALVLAYARHHRIFRLHLSAAAESELFFNRRLDRRLAPADIRHLVDFIRKDGRAEYLLHNAKDPTPDVVLLYWRSLDEWADLVEAYVDDSAQKGSVLTLYELTDGDGTRSTEIHGMDSEVLLKALNVLVKRGKAQIFGQEDSLGIKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRI0</accession>
    <name>A0A367LRI0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">Ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="2 12">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L249_2329</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 12">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + [thioredoxin]-disulfide + H2O = a ribonucleoside 5'-diphosphate + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="2 12"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRI0"/>
    <dbReference type="STRING" id="1330021.A0A367LRI0"/>
    <dbReference type="OrthoDB" id="3000483at2759"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005971">
        <property type="term" value="C:ribonucleoside-diphosphate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01679">
        <property type="entry name" value="RNR_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.70.20:FF:000001">
        <property type="entry name" value="Ribonucleoside-diphosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013346">
        <property type="entry name" value="NrdE_NrdA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02506">
        <property type="entry name" value="NrdE_NrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573:SF6">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51998">
        <property type="entry name" value="PFL-like glycyl radical enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="R1 subunit of ribonucleotide reductase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00089">
        <property type="entry name" value="RIBORED_LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0215">Deoxyribonucleotide synthesis</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="14">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="807"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="872"/>
            <end position="887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCI17055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="911" mass="102452" checksum="2B17AB55C8BA25C9" modified="2018-11-07" version="1">MYVKKRDGRQERVQFDKITARVSRLCYGLDSEHVDPVAISQKVISGVYGGVTTIQLDDLMDSPQAAETAAYMTVTHPDYAILAARIAVSNLHKQTKKQWSSVVNDLYHYVSPKNKRASPRISKETYECVMRHKEELDSAIVYDRDFNYQYFGFKTLERSYLLRLDGKVVERPQHMIMRVAIGIWGDNIERVIETYNLMSNKFFTHASPTLFNAGIPNGQLSSCFLVDMKEDSIEGIYDTLKTTAIISKMAGGIGLNVHRIRATGSDIAGTNGTSNGIVPMLRVFNYTSRYVDQGGNKRPGAFAIYLEPWHADVFDFLELRKNHGKEEMRARDLFLALWIPDLFMKRVKENGDWTLMCPNECPGLADCYGDEFETLYEKYEREGRGRVTIRAQKLWYSILEAQTETGNPFMLYKDHCNRKSNQKNLGTIRSSNLCTEIIEYSAPDEVAVCNLASLALPAFVDYDEGCYDFKKLHDVTQVVVRNLNRIIDVNHYPVQEAYNSNMRHRPIGVGVQGLADAFLALRMPFESPEAQQLNKQIFETIYHAALTASMELAKEQGPYSSYEGSPVSQGILQFDMWDVKPSELWDWEPLRAQIKEHGVRNSLLVAPMPTASTSQILGNNECFEPYTSNIYQRRVLAGEFQVVNPWLLKDLVDMGLWSDAMKNRIIAENGSIQNIPNIPAEIKALYKTVWEISQRQVVQMAADRGAFIDQSQSLNIHMKDPTMGKITSMHFAGWKLGLKTGMYYLRTQAAAAPIQFTVDQEALLVADTNVGRERMPKKRTAPAGTSYMTMPVMVSRPAEARPVQNVVVVDSNGMPTPNTTPPREVKGTDAATPRPLASPSKPPAIKAEKVDGDSPRVLPTEPSSEGIKDGQAEEQSEDKEEASEEREQDIYSDAVLACSIENPQACEMCSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRI1</accession>
    <name>A0A367LRI1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Arginine biosynthesis bifunctional protein ArgJ, mitochondrial</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="10">Glutamate N-acetyltransferase</fullName>
                <shortName evidence="10">GAT</shortName>
                <ecNumber evidence="10">2.3.1.35</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">Ornithine acetyltransferase</fullName>
                <shortName evidence="10">OATase</shortName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="10">Ornithine transacetylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="10">Amino-acid acetyltransferase</fullName>
                <ecNumber evidence="10">2.3.1.1</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">N-acetylglutamate synthase</fullName>
                <shortName evidence="10">AGS</shortName>
            </alternativeName>
        </domain>
        <component>
            <recommendedName>
                <fullName evidence="10">Arginine biosynthesis bifunctional protein ArgJ alpha chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="10">Arginine biosynthesis bifunctional protein ArgJ beta chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_2063</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(2)-acetyl-L-ornithine + L-glutamate = N-acetyl-L-glutamate + L-ornithine</text>
            <dbReference type="Rhea" id="RHEA:15349"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.3.1.35"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N(2)-acetyl-L-ornithine (cyclic): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="10">The alpha and beta chains are autoproteolytically processed from a single precursor protein within the mitochondrion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ArgJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.35" evidence="10"/>
    <dbReference type="EC" id="2.3.1.1" evidence="10"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRI1"/>
    <dbReference type="STRING" id="1330021.A0A367LRI1"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004358">
        <property type="term" value="F:L-glutamate N-acetyltransferase activity, acting on acetyl-L-ornithine as donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006592">
        <property type="term" value="P:ornithine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02152">
        <property type="entry name" value="OAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.340:FF:000002">
        <property type="entry name" value="Arginine biosynthesis bifunctional protein ArgJ, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2330.10:FF:000001">
        <property type="entry name" value="Arginine biosynthesis bifunctional protein ArgJ, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2330.10">
        <property type="entry name" value="arginine biosynthesis bifunctional protein suprefamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.340">
        <property type="entry name" value="ArgJ beta chain, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.70.12">
        <property type="entry name" value="L-amino peptidase D-ALA esterase/amidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01106">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002813">
        <property type="entry name" value="Arg_biosynth_ArgJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042195">
        <property type="entry name" value="ArgJ_beta_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00120">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003802">
        <property type="entry name" value="PRK05388.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100">
        <property type="entry name" value="ARGININE BIOSYNTHESIS BIFUNCTIONAL PROTEIN ARGJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100:SF0">
        <property type="entry name" value="ARGININE BIOSYNTHESIS BIFUNCTIONAL PROTEIN ARGJ, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01960">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="DmpA/ArgJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 10" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_5023392559" description="Arginine biosynthesis bifunctional protein ArgJ alpha chain" evidence="10">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023392558" description="Arginine biosynthesis bifunctional protein ArgJ beta chain" evidence="10">
        <location>
            <begin position="196"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="422"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="427"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="10">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="10">
        <location>
            <position position="118"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="10">
        <location>
            <begin position="195"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI16960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="427" mass="45804" checksum="BF5312C4C69924A0" modified="2018-11-07" version="1">MLKYASSRFYSILGLPRGIPSSKMKWVPESGIYPKGFKASGVYVGIKPTNLSKPDLALVSSDRPCAAAAVFTKNNVIVNSGNANAVTGARALQDTASMAKTTDDRVECPDSTLVMSTGVIGEPLPIKKILDHISVVYYNLGDSHEHWLKCADAIRTTDSFPKLSSRTFKLPSSPGIEYRITGMSKGAGMVNPNMATLLGILATDAPVDPSIIKPMLKYAVDRSFNAITIDGDTSTNDTIALLANGAAGGNAITSEDSSDYRIMRDVVTELAVDLAKLVVRDGEGCTKFVTIRVVDCRTTEAARAIAIAIATSPLVKTALHGGDANWGRILCAIGYALITPPGQPATDVREIDPDRTDVSFIPSDGSPELKLLVNGEPDKIDEVRATEILRAEDLEILVRLGTGDKSVEHWTCDLTHEYVTINSDYRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRT1</accession>
    <name>A0A367LRT1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_2818</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRT1"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI17156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="80" mass="9211" checksum="B10CFB3C9F916EBD" modified="2018-11-07" version="1" fragment="single">FLFRSLEGKAYKILETYLLTKTKDDSLSYEDFYGYVKDLAVKRLDTKLVLPNNLPALTKYSLSILLPKTPLLNRQIDLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LS93</accession>
    <name>A0A367LS93_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_2614</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LS93"/>
    <dbReference type="OrthoDB" id="4924437at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI17313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="372" mass="42450" checksum="93AC25EBEF662F80" modified="2018-11-07" version="1">MHPATRPVFLRDGLRTLNSFSATSSRSDRLNAIDVEDAISFVAQHDSPIHYEALFSVLPKELLKEIWHSWGQTPHTLSNMFYASTDATSVRFVQTTIKWYREAARQKRQTCWPSLGAAQNHISVHRDVLGAINNLLYDPPTVQNDMGLRHLHLPPGELRKDTPICFDSGNNQTRWLTQNWPLWMIRHDSGQAVYASLATIRRHLDTWGGPLSRLLLGMLKEPNEYACNQRPKSYTDFLDHLEQVISRKKAFCISLGKARRRFIPDASHYWFVAGGTEVQDSQRWTFDPLVGWDDSSSVATENVSMSGQPQKHDGAYQEKNDYSNRTWFRSTLVRKPFATNRHWVDVQGSSQGGSEVAREAQRMAQAGIEVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZ34</accession>
    <name>A0A367KZ34_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Pentafunctional AROM polypeptide</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="21">3-dehydroquinate synthase</fullName>
                <shortName evidence="21">DHQS</shortName>
                <ecNumber evidence="21">4.2.3.4</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
                <ecNumber evidence="21">2.5.1.19</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="21">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
                <shortName evidence="21">EPSP synthase</shortName>
                <shortName evidence="21">EPSPS</shortName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">Shikimate kinase</fullName>
                <shortName evidence="21">SK</shortName>
                <ecNumber evidence="21">2.7.1.71</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">3-dehydroquinate dehydratase</fullName>
                <shortName evidence="21">3-dehydroquinase</shortName>
                <ecNumber evidence="21">4.2.1.10</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">Shikimate dehydrogenase</fullName>
                <ecNumber evidence="21">1.1.1.25</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="28" type="ORF">L249_3776</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28 29">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20 21 22">The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 22">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:21257"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 22">
            <text>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21968"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="EC" id="4.2.3.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 21 22">
            <text>shikimate + ATP = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 22">
            <text>shikimate + NADP(+) = 3-dehydroshikimate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17737"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21 22">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="21 22">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="21 22">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 21 22">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21 22">In the 2nd section; belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21 22">In the 3rd section; belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21 22">In the 4th section; belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21 22">In the C-terminal section; belongs to the shikimate dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="22">In the N-terminal section; belongs to the dehydroquinate synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21">In the N-terminal section; belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.4" evidence="21"/>
    <dbReference type="EC" id="2.5.1.19" evidence="21"/>
    <dbReference type="EC" id="2.7.1.71" evidence="21"/>
    <dbReference type="EC" id="4.2.1.10" evidence="21"/>
    <dbReference type="EC" id="1.1.1.25" evidence="21"/>
    <dbReference type="EMBL" id="LKCN02000029">
        <property type="protein sequence ID" value="RCI07428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367KZ34"/>
    <dbReference type="OrthoDB" id="197068at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
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        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
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        <property type="entry name" value="EPSP_synthase"/>
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="Shikimate/glucono_kinase"/>
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            <position position="259"/>
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    <feature type="active site" description="Proton acceptor; for 3-dehydroquinate synthase activity" evidence="21">
        <location>
            <position position="274"/>
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        <location>
            <position position="819"/>
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        <location>
            <position position="1171"/>
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    <feature type="active site" description="Schiff-base intermediate with substrate; for 3-dehydroquinate dehydratase activity" evidence="21">
        <location>
            <position position="1199"/>
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    <feature type="binding site" evidence="21">
        <location>
            <begin position="49"/>
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        <ligand>
            <name>NAD(+)</name>
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    </feature>
    <feature type="binding site" evidence="21">
        <location>
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        <ligand>
            <name>NAD(+)</name>
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    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="116"/>
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        <ligand>
            <name>NAD(+)</name>
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    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="121"/>
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        <ligand>
            <name>NAD(+)</name>
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    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="132"/>
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        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
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    <feature type="binding site" evidence="21">
        <location>
            <begin position="141"/>
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        <ligand>
            <name>NAD(+)</name>
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    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="148"/>
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        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="154"/>
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        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="163"/>
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        <ligand>
            <name>NAD(+)</name>
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    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="164"/>
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        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="181"/>
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        <ligand>
            <name>NAD(+)</name>
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    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="192"/>
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        <ligand>
            <name>NAD(+)</name>
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    <feature type="binding site" evidence="21">
        <location>
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        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="196"/>
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        <ligand>
            <name>Zn(2+)</name>
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            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="249"/>
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        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
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    <feature type="binding site" evidence="21">
        <location>
            <begin position="263"/>
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        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
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    <feature type="binding site" evidence="21">
        <location>
            <position position="270"/>
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        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
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    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="270"/>
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        <ligand>
            <name>Zn(2+)</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="286"/>
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        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
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            <position position="286"/>
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        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="355"/>
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        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="867"/>
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        <ligand>
            <name>ATP</name>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00004811"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00004842"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009948"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
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    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044633"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00048567"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00054455"/>
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    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRNR" id="PIRNR000514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF01761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF24621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="RCI07428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1570" mass="171816" checksum="207E3CFCFC145719" modified="2018-11-07" version="1">MAKLEDRSLEIISVLGEASIVADHALWPSVIATDLFLSTPAFTYVLITDTNLHDIYVPSFRKFFEGHRDKNTTRQLLTFAIPPGEASKCRETKAEIEDWMLSQNCTRDTVLIALGGGVIGDMIGYVAATFMRGIRFVQVPTTLLAMVDSSIGGKTAIDTPMGKNLVGAFWQPRRIYIDFDFLETLPAREILNGMSEVIKTAAIWDEAEFTFLEQHAADILACVRSQGKNRLQPVRHVIKRIVTNAARVKAEVVTRDEREGGLRNILNFGHSIGHAIEAILAPQILHGEAVAIGMVKEAELARFVGVLRPHAVARLSKCITSFELPASLQDKQVIKLTAGKQCPVEELLLKMSVDKKNDGGRKKVVLLSAIGTTHENRASVVADRCIRLILSCSVQMTPGVPPDLQVTVTPPGSKSISNRALVMAALGTGRCRIKNLLHSDDTEYMLSAITRLRGASYSWLDAGGVLEVQGRAGQLQASEADIYIGNAGTASRFLTTVVALCHPANVARSTVLTGNARMKSRPIGPLVDALRSNGVQIEYLEQERSLPLRIHAAGGLNGGLIELAATVSSQYVSSILMAAPYAKTPVTLRLVGGKPISQPYIDMTITMMRSFGIAVNKSDVDINTYHVPQGAYRNPPDYTIESDASSATYPLAVAAITGTTCIVPNIGSRSLQGDARFAVEVLRPMGCVVKQDEISTIVTGPTTGTLKSHPHVDMESMTDAFLTASVLAAVAQGQTRITGIANQRVKECNRIKAMVDELSKFGVKCVELEDGIEIHGNSLAGIRTADATIHCYDDHRVAMSLSVLALVSPGPTLITERECVGKTWPGWWDILSQSFHVALEGFDKSAAAQHTPSVQSPDAERPIFVIGMRGAGKTTIGRQMADLMGWEFTDLDHELERHSGESIIDMVSGSSQWERFRQAELDLLRDIMTRQPQRRIFSCGGGVVETPEARDLLTAHCRCGGRVVLVHRSLDEIIDYLARDTSRPAYPSDVREIYQRRKSWYEQCSNYVYYSPLSRSSGNGVDIFEDLELFTASMCGTSSQFHAMAAKRTSFFVSLTLTDIVKARDMIPGVVNGADAVEVRIDLLADQTPDAILKQVSTLRYMSKRPIVFTVRTKNQGGQFPNDETEKLLVIYHLALKMAVEYLDVEVATDDNILQAVTDSRRHTRIIASHHDPEGILSWRNASWIPFYNRALQFGDVIKLVGLARTMEDNYYLANFKSKILSSQKTPLIAVNMGSLGKLSRILNGFFTPVSHPDLPFPAAPGQMSAAQIRQGLELIGEINPLKFYLFGSPISQSKSPAIHNRLFQQMGLPHRYQLLETDDVNQVQHILQSASFGGASVTIPLKRRVMQLVDELTPAAKIIGAINTVLPMAKGEASSQHRLLGDNTDWKGMLRTLRQNGASSHNRGACAMVVGSGGTTRAAIFTLHSMGFCPIYVLARDSSKAQALAAGFPPEFSIKVVSSQPEVVEEKVCPSVIINTIPGDSPIDRIVKEVLGTTLKQPLEQWTCRLLLEMAYKPRVTPVMRLAEDAGGWKVIPGLEPLVSQGCYQFELWTGIIPSQDEARDAVYDTAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZ75</accession>
    <name>A0A367KZ75_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Queuine tRNA-ribosyltransferase accessory subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Queuine tRNA-ribosyltransferase domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_4555</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterodimer of a catalytic subunit and an accessory subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000028">
        <property type="protein sequence ID" value="RCI07475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZ75"/>
    <dbReference type="STRING" id="1330021.A0A367KZ75"/>
    <dbReference type="OrthoDB" id="27601at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:tRNA-guanosine(34) queuine transglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="entry name" value="Queuine tRNA-ribosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03043">
        <property type="entry name" value="QTRT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028592">
        <property type="entry name" value="QTRTD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050852">
        <property type="entry name" value="Queuine_tRNA-ribosyltrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46064">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE ACCESSORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46064:SF1">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE ACCESSORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="tRNA-guanine transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-guanine(15) transglycosylase-like" evidence="7">
        <location>
            <begin position="25"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="404"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="405"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI07475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="438" mass="47914" checksum="509B6362580DD3E3" modified="2018-11-07" version="1">MSDAPDMRPGNTFRLLNSATPNSCTARLGRLVLPGRRLIETPSYTALTSRGCVPHLTPDNLSKHTSLGTAYMALEDFVERRDPPIYEAPPGGNGRLHSFTALPSDRATILAARRCPPVLAPMGNSRKAVTLFTSTGFSSVTVAEFADAAKRLRPDVIVALGDTLHTSTTPSSRKQVRMTERTEDWLDEFLHHLGGRRGCSEMGIAVFAPVLPVEFPLQWNYLRHLAEDVTYELSGLAIYDVRILPDLVGYPSLSPLPKLSLDVPKTPHEVLRQVALGVDICTIPFINSASDAGVALTFTFPPPPAAGKAEPMGLNMWSPDHAASLRPLLEACPCYACTQHHRAYLHHLLSAKEMLGWSLLQIHNQHVVGDFFAGVRRSLGHGVAYFEQGIEDFARAYEAVLPEGSGERPRARGYHFKSEAGQEKINNPSWTDLAADPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZQ1</accession>
    <name>A0A367KZQ1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small-subunit processome Utp12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_4526</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat PWP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000028">
        <property type="protein sequence ID" value="RCI07452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZQ1"/>
    <dbReference type="STRING" id="1330021.A0A367KZQ1"/>
    <dbReference type="OrthoDB" id="3142434at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000219">
        <property type="entry name" value="Periodic tryptophan protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000470">
        <property type="entry name" value="Periodic tryptophan protein 2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001292">
        <property type="entry name" value="Periodic tryptophan protein 2 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027145">
        <property type="entry name" value="PWP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="149"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="193"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="335"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="377"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="463"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="6">
        <location>
            <begin position="739"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="635"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="852"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="658"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="865"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="877"/>
            <end position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI07452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="894" mass="98818" checksum="344CCE20B4B1E944" modified="2018-11-07" version="1">MTMKTDFKFSNLLGTVYCQGNLLFSPDGTHLFSPVGNRVTVFDLVQNKSYTLPFAHRKNISRIGLTPRGNLLLTVDEDGYAILTNVPRRIAIYHLSFKSPITALSFSPSGRHFVVGLGRKIEVWHVPSTPDTNADGALDFAPFVRHHTHTGHFDDVRHIDWSSDSRFFLTASRDLTARIWSLDAEEGFTPTVLSGHKQGVVGAWFSQDQETIYTVSKDGAVFDWRYVRPINAESDDESDLRWRIVERNYFMQGSSHVRCAAFHPETGLLVAGFSNGIFALYELPDFNNIHKLSISQDAINFVTINKTGEWLAFGASRLGQLLVWEWQSESYILKQQGHFDSINALAYSPDGRRVVTTADDGRIKVWDTESGFCIVTFTEHTSGVTACEFAKRGNVLFTASLDGSVRAWDLIRYRNFRTFTAPTRMSFSTMAVDPSGEVVTAGSLDSFDIHIWSVQTGQLLDRLSGHEGPVSALAFAPNGATLVSGSWDRTARIWSIFGRTQTSEPLQLQADVLAIAIRPDSLQLAVSTLDGQLTFWSLAEAEQVAGLDGRRDVSGGRHFTDRRTAANASGSKSFHCIRYSLDGSCLLAGGKSKYICLYSVTTMVLLRKFTVSVNLSLSGTQEFLNSKLLTEAGPLAGIDDDDADDGDGRRGPRLPGSKRGDPSARKQMPEVRVTGVDFSPSGTAFCAASTEGLIIYSLDAMPQFDPLDLDMEVTPASTLAVLTTERDHVKALVMAFRLNEQALIQHVFQAVPTGDISLVVSALPDVYVPRLLRFVAQQTEQSPHLEFCLHWTKALVDSHGPWLAANRGKVDLELRAAARAIGQARDEVRRLADENAYMVDYLLAQAERDHPADRNVMEVEADEGAEGRGVKRRASDMEEGEDNDEDEGEWHGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZT8</accession>
    <name>A0A367KZT8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_5678</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000024">
        <property type="protein sequence ID" value="RCI07688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZT8"/>
    <dbReference type="STRING" id="1330021.A0A367KZT8"/>
    <dbReference type="OrthoDB" id="432010at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000043">
        <property type="entry name" value="Amidohydrolase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF31">
        <property type="entry name" value="AMIDOHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_7G05840)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="4">
        <location>
            <begin position="34"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI07688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="336" mass="38256" checksum="D8B603A5916D1FE5" modified="2018-11-07" version="1">MLGKVALEEAFALPRLHEKTRWWASMFAVDPEKHAAEMKDITDLRIQSMDRHGVGFSVLSYTAPGVQDIWHREEASRLAVEINDYVAEAIKHHRNRLGAFATLSMHDPHEAAAELRRCVRQLGFLGALVNDTQRSGPEGDDAIFYDGPDWDPFWAAVVDLDVPFYLHPRNPTGTLHDRLWADRKWLIGPPLSFAHGVSLHVLGMVTNGVFDRHPSLQVILGHLGEHIPFDLWRINHWFEDVKKPLGLACKGTIRDYFRRNLFITTSGHFSTTTLQFCMAEVGADRILFSIDYPFESFADACDWYDGLPINLIDKIKMGRENAKKLLKLADYKDSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZU3</accession>
    <name>A0A367KZU3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="19">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">L249_5733</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14 19">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 19">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="19"/>
    <dbReference type="EMBL" id="LKCN02000024">
        <property type="protein sequence ID" value="RCI07684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZU3"/>
    <dbReference type="STRING" id="1330021.A0A367KZU3"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000048">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000067">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000009">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF5">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9 18 19" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 17 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 19" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 19" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="211"/>
            <end position="228"/>
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    </feature>
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            <begin position="1093"/>
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            <begin position="1137"/>
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            <begin position="1222"/>
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        <location>
            <begin position="155"/>
            <end position="208"/>
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            <begin position="1030"/>
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            <begin position="357"/>
            <end position="376"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
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            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="129"/>
            <end position="141"/>
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    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="16">
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            <position position="602"/>
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            <dbReference type="PIRSR" id="PIRSR606539-2"/>
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        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
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        <source>
            <dbReference type="RuleBase" id="RU362033"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <sequence length="1266" mass="139777" checksum="19355966C86DFB85" modified="2018-11-07" version="1">MPPSPPYRAPDSPTPDSDSDLDLELAIAELDPISTEPPPTAVSRRRPSTAEQRTSRIALRNLRMGSLRRAHKRGRGYGDLGAPRDHSTDTDGFSSGNGDDDVPLLGGEQPSHPPRRRESRVRLPAFMSRTEDDGPRDKPEDDASTSRTVVVGSSQATRFPANLVSNAKYTALTFLPVTLYNEFSFFFNMYFLLVALSQAIPALRIGYLSTYIAPLAFVLLITMGKEAYDDIERRRRDTEANSEPYRVLAFGDLESNASLLRPRRPLKSDTMRRGSRRSRRNDLSDIQEENDPVQAVTPSSHVQEVSRKSKDLKVGQVLKLSKGQRVPADVVILQCCTSDGCAAKEPAEEEALLALSEEGQASKGKQPAAEALMHEPETGTVGETFIRTDQLDGETDWKLRLASPLTQNLSPEEFVRLRVTGGKPDKRVNEFFGTLELLPPRQEATSSQEEENAKSWALSIDNTAWANTVIASQGTTLAVIMYTGPQTRSALSTAPSRSKTGLLEYEINSLTKILCALTLALSIILVALQGFEKTGGNIWYIKIMRFLVLFSTIVPISLRVNLDLGKSAYSRFIQNDPGIPGAVVRTSTIPEDLGRIEYLLSDKTGTLTQNDMELKKVHVGTVSYANEAMDEVAAYVRQGFCNNTTNQLVTPSYSAAVNVGTTRTRRDIASRVRDVVLALALCHNVTPTVDNEDGRQVTSYQASSPDEIAIVKWAESVGLKLASRDRKSMTLQSTESGRTVVCVRILDVFPFTSDGKRMGIIVQFQEDASVGNADLGNGEIWFYQKGADTVMSSIVAANDWLDEETANMAREGLRTLVVGRKKLSAQQYREFSSRHHDASLALAGRDAGLQAVVSRYLEVDLELLGVTGVEDKLQRDVKPSLELLRNAGIKIWMLTGDKVETARCVAVSSKLVARGQYIYTVARLKKKDYARDHLDFLRSKTDACLLIDGESLALLLTHFRLDFISIAVQLPTVVACRCSPTQKAEVAKLIKDYTKKRVCCIGDGGNDVSMIQAADVGVGIVGKEGRQASLAADFSIEHFCHLVKLLVWHGRNSYKRSAKLAQFVIHRGLIIAVCQTMYSIALKFEPEGLYKDWLLVGYATVYTAAPVLSLVLDQDVDENVANLYPELYKELTSGRSLSYRTFFVWVLVSIYQGGMIQGLSQLLTEVDGPRMVAVSYTVLVLNELVMVAIEITTWHPVMIISILGTFFIFAGSVPFLGGYFDLKFIITLGFFWRILAIGAISLVPPYAGKLIRRAIKPPSYRKVQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L013</accession>
    <name>A0A367L013_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_5721</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000024">
        <property type="protein sequence ID" value="RCI07769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L013"/>
    <dbReference type="STRING" id="1330021.A0A367L013"/>
    <dbReference type="OrthoDB" id="508119at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF21">
        <property type="entry name" value="QUINATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="133"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="194"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="282"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="324"/>
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        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
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            <begin position="383"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="422"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="32"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="500"/>
            <end position="524"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
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            <dbReference type="ARBA" id="ARBA00010992"/>
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            <dbReference type="ARBA" id="ARBA00022448"/>
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    </evidence>
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            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI07769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="524" mass="57080" checksum="DD25E5115DC5B2FD" modified="2018-11-07" version="1">MALLVRLLRLVVRNEAMRQDPVEIYGWRVFALVCAACFGGMLFGWETGAIGGILAMKPAQERFGTLHRSKAERSDLDQNIVSTLQAGCFVACLLTSWLTERFGRKPCLVATGGLATIGVIMQAASAVHGSLSVMYAGRFIAGLGVGAASTLTPLYVSECAPRAIRGGLTAFYQLFIVCGIMLAFWVNYGCVLHVAAPAVFILPLSLQALPAVPRWVARQDDWERATNILVDLRGLPADSDYVSGEIREIADQLEAERRLMGDATALTLLKEMVLIPGNRNRAIISVVLMICQQMTGVNSINYYAPQIFQNLGMDGTNTSLFATGVYGVAKTAACAAFLVFVADSLGRRWSLLWTSAAQAVVLYVIGIYGRVQPPVAGQPVTAFGYVAIACIYLWAAAFQFGWGPACWILVSEMPTARLRAMNVALAAAVQWLFNFVMARTVLTMQNTMGRAGYGMFFMFGSFDILMGIFVWFCVPETKGLSLEKMDELFGVTEQAKRLDAELAEEHPRPESVPESVKEIHAGKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L047</accession>
    <name>A0A367L047_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ASX DEUBAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_5707</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000024">
        <property type="protein sequence ID" value="RCI07777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L047"/>
    <dbReference type="STRING" id="1330021.A0A367L047"/>
    <dbReference type="OrthoDB" id="2289918at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028020">
        <property type="entry name" value="ASX_DEUBAD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13919">
        <property type="entry name" value="ASXH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ASX DEUBAD" evidence="2">
        <location>
            <begin position="23"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI07777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="161" mass="17836" checksum="87FD3CA5EB833A64" modified="2018-11-07" version="1">MPSSPQPSTQAQVSAARIPRRKPAAPRRARQRASKLLTSTTSPLAQADLRSILSNPVAWTALDATDRAKILALFPDRQHVIESGPDSRPNFATLMNDDSFRYDCAAYTTNLAAGRHDEEWLADAWAAHERRKAGDFDAYLDNKFADEWLARPESESSQSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0E3</accession>
    <name>A0A367L0E3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Proteasome alpha-type subunits domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_5839</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000023">
        <property type="protein sequence ID" value="RCI07900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0E3"/>
    <dbReference type="STRING" id="1330021.A0A367L0E3"/>
    <dbReference type="OrthoDB" id="268479at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03757">
        <property type="entry name" value="proteasome_beta_type_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000027">
        <property type="entry name" value="Proteasome subunit beta type-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF2">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI07900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="263" mass="28808" checksum="DAAAB4183ECD0F25" modified="2018-11-07" version="1">MAATYSQCPAMDGPSYSFSEAPRTAGEPNQHNFYPYTDNGGSTLGIAGADFAIMAGDTRHTSGYSINTRMAPKVFKVGGSTSSQEDATIVLSVCGFAADGTALRDRLDTICKMYRYRHGKPMTLNACAKRLSTILYSKRFFPYYATAMLGGIDEEGKGAIYSYDPVGSYEREQCRAGGAAASLIMPFLDNQVNFKNQYIPGSGIGHELKERERHPLPRSRVETIVKDAFDGAAERHIEVGDHLQMLIVSKDGIEEMMLPLKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0E7</accession>
    <name>A0A367L0E7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5856</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000023">
        <property type="protein sequence ID" value="RCI07886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0E7"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI07886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="114" mass="12496" checksum="F2F0155408122658" modified="2018-11-07" version="1" fragment="single">FHWAVRGARPEKKKGGLGVQTSRDTRPDNSLTTSFSPMKTHNTSLAEALQPFTFGYQCTGTCGRLACSLFFLLSSPSTIFAPPLPLFIGGPSSYRESLSFSPPDPYNIREYGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1D9</accession>
    <name>A0A367L1D9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7883</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000022">
        <property type="protein sequence ID" value="RCI08032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1D9"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI08032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="117" mass="13479" checksum="9AAD3624C2AA93B0" modified="2018-11-07" version="1">MMSNQGVDHVIEKKKTNHVMVVLSDEVKADNKLEVVLYYSTMTWLYVTPFHFNYSASIAYSAPIDVQRADRCDDRCNESIGRYDRYSPTVTQGVVAGLRPNWYNLFQVALQAYFLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1M9</accession>
    <name>A0A367L1M9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DUF788 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_8769</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM208 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1M9"/>
    <dbReference type="STRING" id="1330021.A0A367L1M9"/>
    <dbReference type="OrthoDB" id="10012212at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008506">
        <property type="entry name" value="SND2/TMEM208"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13505">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13505:SF7">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05620">
        <property type="entry name" value="TMEM208_SND2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI08325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="159" mass="17274" checksum="39BAB5E3CB33F987" modified="2018-11-07" version="1">MAQKAKKDLAKNNAAALNRLHLISVLANGLFLVSHLFLRRRSLLVYGLLSLPAFVCQYVLEISGRPKYDAITGALKSSGQDLAARGLTEYMFDVVWVTWVCCAAVMLAGNWAWLLWAVIPAYGVYLGAGLLGMGRQQLAGMQAGQDAAPPANRRARRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1V8</accession>
    <name>A0A367L1V8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1V8"/>
    <dbReference type="OrthoDB" id="47172at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016867524" evidence="1">
        <location>
            <begin position="18"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="329" mass="38067" checksum="ADAAF733AF4BD3D0" modified="2018-11-07" version="1">MLVTYILLLGLLPLCVAGSRLAPKYLDDIEPLLSCAKMKDSTFTFVLNHTLFTAERFNTKKSCVTWECVRLVVETLPDEFIESIRPITGRSKHRLIDDITGDLSFISDARYGQFLSWIMSAGLRRQTVCWLTSETDLFRYYEDPLGAIAAYLIDPSTIDGTVYRRFATLPDGPLREDQTMCFSPDSAYYQQIHRSLPQLRVRNYLQYQPKFNTYEHIRWHTSRWSGLFGRALFEMTQKSYSCSGYCGCDPSLESSRPMIPQSYSQLWTSVHWLMERNKPFCLSTGWGNAGQVKHHYWMAVRGGKKISQCRMMSPPTLSRLMTKKPNKYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2D9</accession>
    <name>A0A367L2D9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme E2 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_4732</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2D9"/>
    <dbReference type="STRING" id="1330021.A0A367L2D9"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23813">
        <property type="entry name" value="UBCc_UBE2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000073">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="9">
        <location>
            <begin position="2"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI08600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="173" mass="19512" checksum="27B0806D5C2B6480" modified="2018-11-07" version="1">MALPKRIVKETERLMAEPVPGISAVPHDDNLRYFDVQIHGPSQSPYEGSTLRGIFKLELFLPDDYPMTPPKIRFLTKIFHPNVDKLGRICLDVLKSKALPPAFRFYMLTSLSYPSDNWSPALQIRTILLSIQALLGAPNPDDPLAADVAKSWKQDEQAAILVARDWTLKYAKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2E5</accession>
    <name>A0A367L2E5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_8867</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2E5"/>
    <dbReference type="STRING" id="1330021.A0A367L2E5"/>
    <dbReference type="OrthoDB" id="2135488at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052350">
        <property type="entry name" value="Metallo-dep_Lactonases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43569">
        <property type="entry name" value="AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43569:SF2">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="3">
        <location>
            <begin position="231"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI08392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="376" mass="42073" checksum="F70E71296721C964" modified="2018-11-07" version="1">MATQQEAPDPDSSVMLPIIDAHVHLWPGSQVKSLPWCTATTSPLAGQHSVKEYLQGCTSRSQLVGFIAVEADRARRRPRRRRGNQEASGEEEDEEEEEEDWESPLEEVAFFGRVATGTPREGEGHSPSDATLCLALIPWAPMPAGARTLDKYLGRVREAAGEEAWAKVRGFRYLLQDKAHGLMLEPAFIDSLKLLGKRRFVFEVAVDQHRRGKRQLEELVEMVGRAHEGVPEHEKVTFILNHLCKPDLTIYNLGSDPSFHAWRTAMYALSKAPRTYVKLSGAFSEMSPKLRSEPAPLIFRSMLAWLGILIATFGPGRIIFASDWPICQHDGAAGGKDDDSWSKWRDVVDKMCWMATLDDVDRAMIFGGTAKKAYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2I6</accession>
    <name>A0A367L2I6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2I6"/>
    <dbReference type="STRING" id="1330021.A0A367L2I6"/>
    <dbReference type="OrthoDB" id="4828117at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="303" mass="32842" checksum="400F613B7051D5AA" modified="2018-11-07" version="1">MAPKSTPTTKANYKSYEAQARMIRAMVAAHPDVKWNYKEIAACIGSDISEHAVNHRFRPIRAQAAIIREARAQGLDIKDLLSQDELPATQEAIDKQNIAKYFGQSTGDGIQFQFRGIKRDAELLRQTEAEGGDVAACLTSGSPGSAMTTTPSRATPSRRGGKAGGRARERAGGVRKRGRATIIKRASSDDDDDDVDDDDDEDDENDDGDEEASLNWDARDVTPSAKRPKTTPAQKSVVPRRAAQRASATIADAVAQLRDSPSPSPSPKVEVTDADPIHVRSIFGPHNGRFTPDMNDEYGDGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2S0</accession>
    <name>A0A367L2S0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_4819</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2S0"/>
    <dbReference type="STRING" id="1330021.A0A367L2S0"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="3">
        <location>
            <begin position="45"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase type 11" evidence="2">
        <location>
            <begin position="278"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI08708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="493" mass="54118" checksum="90AA16BDBFD0D27D" modified="2018-11-07" version="1">MDDVFQAERIFDDIGHSYETAYGNNPGLDSLLARVGQHVSPDASVLDVGCGTGQPVSAYFAGKGCAVTGIDVSQVMVDLCRSKIKGSFIKADMTTFEPEGKKKFHVVLAIFSMLQMPYSNVCSMVYRLASFLRPDGLLCLGTLTAEFVRGIIDDHHDRDPTGDYIEGVLAPFMGKTVRITALSEAAWLRIVKQAGLSIKSAEHASVQPDDPSALEEKHFFIIAQRQHLHPLLGPYPLPLQPPAPHRLDQAGWQPLAERFIRSELPAVLEAVKDNKEVLDVGSGHGELPMAIAKRVGKAYAIEPNSDRSKLLVDKGKGSNVHIATGTAEALPYADKTFDAVVAMWILHYVDDVEKSLSEMTRVVDREAPEARIVIVQGAPYNEAVDMINAVCGPIVDKIDHQGYFLSKACHVFRARGFGDIALEPVNVTCAFPEEELSVRCSTAAEVLANFWYCSHAKVEDMKKAFIPVLERHFKYKPFEVGDQAVMLVARPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3P7</accession>
    <name>A0A367L3P7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI09053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3P7"/>
    <dbReference type="STRING" id="1330021.A0A367L3P7"/>
    <dbReference type="OrthoDB" id="4925409at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="946" mass="108859" checksum="F4E870CE69A8B892" modified="2018-11-07" version="1">MLHTPSCSYRLLRDDFPQECQQFETRFHDSDSDSDSDLDEVEWFRSLYTCPSEAKDILKMDLEVQGRNRFFQRYRFGQLWFETRTLYAKKQRRSIFNRMVAFIGRSNNNNNNGRSSSFAQRLYGRGVRGILPNHRIIPPPIPTAYSSTGVPHYEYWYSDHFLLDDDTVTNQVPDRPFQMIPRDGGRWLPAVKYRPMGQQQEDNTTLPDSFVEFVDLPPVWDSFPGALGSNWYFLPMSERSHAGDRPAEESSTTSWGYYTPSPTGSSLTSSQDSAPGSSSPRYMYPNIANPNVWNRVEQLREAVTYIRRSSHHDTPIFVSWARQLLNDYLALASSLGHNVHIKHGKPGDWCYSETLRLLDSVPHLVDSVIQLYNIIRWTADNIGQSPSKKRKGLGKRSSSSGEEEAEEEDFCQPPMSALEDKDKDPMTPGVYLTCRNPAHNSRLFLGRYSQAELCNIMQLSPCPAAPTGYECVSEQVPTVNLTSDYYPSPVNCSHFTEVHLGFQLTGSQAAETMDTIKLQFGHHGLHTIAHSPVSMFHQWQKLNLTDMFGSNEVLVDDLRHMKLWAFKNSEPHDGFHLLGMKLRAKCPDSTTYKMDQFKLLNKWLERPSGQDEAMVWQGTIAPPEWQLPSVLDSCAEFHRLSVSFQPKYGIDGSQDLLRMNLGGYPNRDDVFQLLGNHRHGKEFEHWANIDIEAMFGRKTIAVRDITYVALIQDHRTNSENRWLTQGLKMRGQCVGSNKELGLDKFHRLQSQSQVEYLLPTLSTWTGDVNPSSDWRQLTTECTRIDKLKVHLGMGGNLGGGTSETLMIRFGRNTKNPPTEMVDEPYRDTWYNREVDLNKVFGTETVFVRDLDKFTVYSVKKPWQLTAKRMDMWMISSVFFTARCVDYPSRWIRNNQHMNVNEWFEALGKDNYARELVRPLSFEKWFWVDKAPKPEEKSGGLHEAGEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3Y8</accession>
    <name>A0A367L3Y8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_1549</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367L3Y8"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF18">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="9">
        <location>
            <begin position="18"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="10">
        <location>
            <begin position="947"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="2317"/>
            <end position="2381"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="7">
        <location>
            <begin position="947"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="7">
        <location>
            <begin position="1097"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="7">
        <location>
            <position position="979"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="7">
        <location>
            <position position="1161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI09139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="2381" mass="258473" checksum="5C1C31141555E736" modified="2018-11-07" version="1">MSVNGTLSALQSLKRHVKEPIAVVGMACRLPGNSNSPHALWEFLERGGIADNTPPESRFRLEAHYDGSDKPKTMRSPGGMFLESVDVKQFDAAFFGIAKADAIAMDPQQRQLLEVVYECLENAGVTLGKLDGEAVGCFVGAYAVDYADVQGRDPEDRVASIAIGAGRAMLSNRISHFLNIHGPSMTIDTACSGSLVSLDIACRYLSNGEMTGALVAGASLYFSPDHNEEEGAMRGAYSPSGRCHTLDKKADGYIKAEGVNCVMLKRLSDAQRDGDSIRAIIRGTATNHDGLTPGIASPNWQAQADVTRAAYANAGIDDLSATGYIEMHGTGTRAGDPEEVKGVASVFAPSRPHDAPLVIGSIKSNVGHSEPAAGISGLIKAILAIEKGRIPGNPTFVDPNPEIDFNASRVRASRYTIPWPAPSGGLRRASVNSFGFGGSNAHAIVDQVPEEMQNYTSSFASASDDLLEEPEAVTRPHVLVFSANDSGSVKSYAKSLRKHLLDPRVRVDLPTLANTLSERRTLHFHRGYLVTDDLKLDVESIAYGKKSPEPPRIGFIFSGQGAQWSQMGRSLIDNFPEARATVERLDTVLQGLLHPPSWSLLDELYEARSPEKLRRPELSQPLVTALQIAILSVFRTWGVTAGSVVGHSSGEIAAAYAAGLLSEDNAIKAAYYRGYAAVRRAQPRKKEMGMMAVGLGEREVREYVSKAALDEPSGGQAVVTVACYNSPGSVTLSGTRVDLEALRQVFVADKVSARMLQVDMAYHSPFMAATGDEYARCLKADAFSILQPHDDKTKMFSSVDGHYKTSRLVDVDYWYSNLMQPVLYHQALHNMLSQEECAPDFLIEIGPSDILASPTIQVKKQLPDGGSGVQYCAAMKRGQGAERAIFDVGGRLFLAGQAIDLTVVNGTQDAQRKLLTDLPNYCWNHEVAYWHESEASTDWRNKQFAHHDLLGSKLLGSAWQAPVFKKKLSLDDLPWLRDHRIGRDILFPAAGFICMAAEAMMQTDAMLRPESELEPKHDQQVRLRNVSFNRALILEEGKGTKILLTLTPHMGQNGSWYHWAVRSRVEASWVDHCTGQVRIVNDPAHVAKKPSDISPLQHPTPGSLWYKALSDVGYDYGKSFRKMMIVETTSGSRESRAVVDVLAPPSRYAQSHYPIHPAALDGCMQCALTGMWRGIRSSVSSVLVPCMIDDILLSRKGRGDEDRVIAVTKSVFVGPGRTDLAVNYSPNLELYHPETGDLILRITGLSYRALDSQDTPYSAHRCSRLVWKPDVTLSPQACAAGDSRGWNKVQDIADLIAHKKPNAKVVEASLVPQDSASVWLEGISAESKARNAFVSYSFLSSDVEAVAAAQDKYEVIPRTAFQLSDISKPTTTTDVPGKSPQSTDLVILRLPALREAETIQRVLENVRRMLRADGHVLVLEQRGVWDAAADDAPTSGGGPVMNGGSCACDGILEANGFSKLYTLDCLESLSLCRAHLATTTTTPTATGAPLDVLHLAEPGALSKKIVKALADLGWDVREQYMGQPLAQIRAESTVVVLTEVETRLLPSPGAEQWTVYKELLQMRSNRIVWLSRSAQLTVANPDGAIIYGLCRSIRMEDPSMSITILDLEDPDNDAGIPCIDLLLRSIRGQASTGGKDVEYLERGGVLHVSRVLADDGINAAARGHASVKMRLHEADGTVRMIADRVGSLDSLLYAQVDPEPLPLADNTVEVELFASALNFKDVAVAMGIVPENELLLGGEGAGTIRRVGANLNAHFDVGQRVLVFGKGTFANRIITTTERTVAIPDWLSYEDAATLPSVYLTALYSLDNLSDVKRGDRVLIHSATGGLGIASIHVCRAMGAEVYATVGQDAKRRFLTERFAIPEDHIFNSRNANFERQIMEMTDGLGVDIILNTLTGDLLDASWRCIADGGTMVELGKKDHIDRNKLAMEPFARNASYRCFDMSHKHVTDTVIADLMKKMMKMLVSGTIEPIAPVTLFPYNDIPSAFRYLRSANHIGKVVISNKELDSPDPVVAVRPVPRKLRLRSHVSYLIVGGLRGLCGSLAVEMARLGARNVVVMGRSGFDDAQSQIVLKDLSAEGCHADLVRGDVSCLEDVRRAFNKATKPVGGIVQGAVVLRDRPFEGMSYDEYCAVISPKVAGTWNLHNVALEMRRELDFFTMLSSISGLIGHLGQANYAAGSTFLDSFAYYRRGLGLKANSVNLGPIQEVGCLSRHDGLLTSLYKAAWTPFNEALFLKVVGISILQQEEEPVNAASCAQLITSIAVPQPPSSALLPRDTRFSSLLFGEGAVPDAARDAGQDPGNRQMQALLVTIRSGAADASSAKTIKDAVADVVNRQFVSTLGLDEPLEPTKPMSSYGVDSLTAVEFRNWCRAQLAVDLSTMGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L457</accession>
    <name>A0A367L457_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF427 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L457"/>
    <dbReference type="STRING" id="1330021.A0A367L457"/>
    <dbReference type="OrthoDB" id="18996at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.40">
        <property type="entry name" value="Domain of unknown function (DUF427)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007361">
        <property type="entry name" value="DUF427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038694">
        <property type="entry name" value="DUF427_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34310:SF9">
        <property type="entry name" value="BLR5716 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34310">
        <property type="entry name" value="DUF427 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G02220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04248">
        <property type="entry name" value="NTP_transf_9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF427" evidence="1">
        <location>
            <begin position="29"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="DUF427" evidence="1">
        <location>
            <begin position="151"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="262" mass="29229" checksum="7DC5BE3D9293163A" modified="2018-11-07" version="1">MAGTDLYELASFLAANGPHKVLPTSRRLRVVFNRVVIVDTTSAVFVWEHDRYPQYYVPATALVGCTVRDKRRLGDEKAAVVELTAGSPGDDKVTTDRVLRFANDPGLGPLANLARLEFGAMDQWLEEDAPVYVHPKDPYKRIDVLPSSREIQVKIGRHTVAKASSSVHLLETSLPPRYYISPGAVDPGLLRKSSLTTKCPYKGEAEYWHVVMDGKEVENVVWQYRIPTLESSGIAGLLCFYNERVDVYLDGVLQERPTAHFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4R8</accession>
    <name>A0A367L4R8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RecA family profile 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_3756</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000015">
        <property type="protein sequence ID" value="RCI09425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4R8"/>
    <dbReference type="STRING" id="1330021.A0A367L4R8"/>
    <dbReference type="OrthoDB" id="5957327at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033063">
        <property type="term" value="C:Rad51B-Rad51C-Rad51D-XRCC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033065">
        <property type="term" value="C:Rad51C-XRCC3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000707">
        <property type="term" value="P:meiotic DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052093">
        <property type="entry name" value="HR_Repair_Mediator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46239:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46239">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 3 RAD51C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="8">
        <location>
            <begin position="35"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="323"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="392"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI09425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="401" mass="43106" checksum="45E7A5B627F572AA" modified="2018-11-07" version="1">MDYDSFHGKDIASFDLRDTHRLPTVAASQALEEFEKDPLPTGLDRLDRALSSGHRGGFKRGQVTEVWGPPGAGKTAFAIQTAAHAICSGHDVAWVGRSRLLAAILRPLLEAKHAAFIDCFHKLHEERITRVVESVERRRLQDGSALPRGKFTLLSCLTLPHLMALISRPTPRLIGSRVCLIVISSPSALIDSALPKSQDPVPGSKPAGRGFGASAKRSQGLQFVMGALEKLAATRKCAVVMLSQCATRMQSEQGATLVTAVNNLVWDQGVTTRLVLFRDWAWQGGKLSSVFMAGLQKLDGQATTDAIDPVFTFSIGADGVTEHVTSSLPDRPADFSVPSRKRKLGQAELEVPDSDDDDDDDGAYGWAAEDEAALPAPPPQWQGSEDILLGPSGSSDGESPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4W6</accession>
    <name>A0A367L4W6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_3997</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4W6"/>
    <dbReference type="OrthoDB" id="3142841at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052979">
        <property type="entry name" value="Adenylate-forming_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927:SF5">
        <property type="entry name" value="ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01222)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33927">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="635"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="678"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="705"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="745"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="781"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="819"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="92"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI09476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1052" mass="112776" checksum="3825444786377A65" modified="2018-11-07" version="1">MAVSASGDRHGATAAAQASRPSSSSSSTCSSSSSHHSSSSSSSSSSAASIMSESTATSSSSTSSSSYPSSIPSDFCYGPVVQRPFPTLTAAFYHQAATWPSAIAVRDLAAATPREVTYRDLASHAQALALRLRALGVEPGQRIPLVVKRGLDMLVGIWAVLSCGAQYVPLDGGVVPDSTIRHVVHQAGGHVVLCLSSTEHRLRNLFPCLTPVLIDQCLALEPLDQGVLDLAAPDMGCYVIYTSGTTGKPKGVDVTHNNVANLVCLSPGGLGVRPGMCVGQVLNISFDMAAWEIFACLCNGGTLVVRGSEWESTIRQLDVLICTPSILSKYPPEEYGNIKIVATAGEPTCQDLADRWASHGTYWNCCGPTETTIVNTMSRHVAGEAVSIGRPTPNNTVYILDEAGKPVPMGEPGVMWAGGHGISRGYVGLEDKTRESYVPDFFLGDGWRMYCTGDLGRWRSDGSIDILGRCDDQVKVKGFRVELDGVATSLADAAGVSRAAALLIDGEIHGFVVPSGQDTDAILSHARRLQPYYAVPSRIHQLDAFPTTANGKIDKKALREDVVDRQRQLRASDCGDTLAETLSVTSSSSSSCSSSSSSTLTAVSEDSLARPMDDKKLPRPLRGLRHRVLIVYRRLFSLVWLLNLAALAALLVLMPGMEWFAVLTAANLVTAVLVRQDGVINLLYAVFCSVPVSAPLWLRTRCAKIYHLGGVHSGAGVCATAWLLASSVRSTVVYAQLGRPGPGESLPGFVVSWLLSALCCAMVGCAWPSFRKRHHDVFERLHRFLGWSALALFWARTVLSARDGSRGDDVGNALLRSPSFWMLGVATCSIASSWLWLRRVRVDAIPLSDHAIQLSFDYAVPVNGSFTRISTRPLLEWHSFATIPAPHGTDSEKLANRPGYSLVVSNAGDWTKGCIRNPPSHVWVRGQPTCGVMRIATLFNRVVVVATGSGIGPLLGHIGQPSCPTQLIWSAPSPEKTFGKGILDTIRRSIPDAVIHDTRLKGRPDLVTMAFNLARDFEAEAVIIISNEKITKKVVYGLETRGIPAYGAIFDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5E2</accession>
    <name>A0A367L5E2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">histidinol-phosphate transaminase</fullName>
            <ecNumber evidence="4">2.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Imidazole acetol-phosphate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_4169</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23744"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="2.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.9" evidence="4"/>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5E2"/>
    <dbReference type="STRING" id="1330021.A0A367L5E2"/>
    <dbReference type="OrthoDB" id="2015537at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01023">
        <property type="entry name" value="HisC_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42885:SF2">
        <property type="entry name" value="HISTIDINOL-PHOSPHATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42885">
        <property type="entry name" value="HISTIDINOL-PHOSPHATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="12">
        <location>
            <begin position="59"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI09631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="421" mass="45154" checksum="F17A596567F7B61C" modified="2018-11-07" version="1">MSPFRLETCARPNILSLQPYRCARDDYKDDGSNVLLDANENAYGPSVDSSSLAALNGLGFDPSGLHRYPDPHQLELKQQLCRLRNTNAHTDKPLTADHVFVGVGSDEAIDALMRCFCVPGRDRMLTCPPTYGMYAVSAQVNDVDTVRVPLGPAPDFALDGPAIAAALDQSSDNVKLVYLCSPGNPTGSLLAKADVERLLAHPTWNGIVIVDEAYVDFAPDSASLAQLVAAHPNLVVMQTLSKAFGMAGIRFGAAFASPPVARLLNALKAPYNVSTPTSALAAAAVSEPGLAAMRRNRERILSQRDRLLRELPLIPGIGRLRGGTDSNFLLYEMLDSKGRPDNAVALAVYQGLAESERVVVRFRGKEHGCLGCLRITVGTEQEVTTLLRSLRTRLAEVRNATPAADGEKEIANELAANGVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5J2</accession>
    <name>A0A367L5J2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_4095</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5J2"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI09706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="66" mass="7344" checksum="45820A40D9A6F8E2" modified="2018-11-07" version="1">MTNAGLTSLPSFFFPLSYSPSHPWQGTEKGPRKNSTYRANKVSLRDTIPSFSYVSKSCDSIELPTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5J5</accession>
    <name>A0A367L5J5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA-directed RNA polymerase</fullName>
            <ecNumber evidence="11">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L249_3960</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the phage and mitochondrial RNA polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="11"/>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367L5J5"/>
    <dbReference type="OrthoDB" id="276422at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034245">
        <property type="term" value="C:mitochondrial DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001018">
        <property type="term" value="F:mitochondrial promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006390">
        <property type="term" value="P:mitochondrial transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000041">
        <property type="entry name" value="DNA-directed RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.280:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1320.10">
        <property type="entry name" value="DNA-directed RNA polymerase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024075">
        <property type="entry name" value="DNA-dir_RNA_pol_helix_hairp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046950">
        <property type="entry name" value="DNA-dir_Rpol_C_phage-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002092">
        <property type="entry name" value="DNA-dir_Rpol_phage-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037159">
        <property type="entry name" value="RNA_POL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029262">
        <property type="entry name" value="RPOL_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10102">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10102:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00940">
        <property type="entry name" value="RNA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14700">
        <property type="entry name" value="RPOL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01311">
        <property type="entry name" value="RPOL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00900">
        <property type="entry name" value="RNA_POL_PHAGE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00489">
        <property type="entry name" value="RNA_POL_PHAGE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 11" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase N-terminal" evidence="14">
        <location>
            <begin position="331"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1348"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="466"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1348"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="1374"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1395"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1410"/>
            <end position="1423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCI09492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1469" mass="165874" checksum="D0F5C4DF4D104F2E" modified="2018-11-07" version="1">MLSRQARCGLLTPQSAVSQPNRATLKCCAPRVSTLSPRRRLLITRLSQMRDQAQERHGFVQRRLFATAVEQYQPFYNPSLPPLTASPRYLDPPKPLILPDTAHWRSMTRINPSGIPGNIDDMLSLFHACISVGKLERAALVIKRCYVMGILSPEERILLNNKYLRASLDHIRHRPGKKQAEGLHKWYELQIRSKRLPQTAETVACMLKASLLSEEGSRLERLVKRYMDMAPGEAGLRVLNMSEILNDRDLAVITDICPTYNLSEEENKEDLLANGEGETEEDTPPQEQDFPKVQETPQSGLGLASLRRGLSLFETLKDVDVSSLSKAEQHRIQLMLERDSIDSAIVKWRHDRKALQKAGITMECGSPKAGSFFSQNLAVWLDAMENRILQELEMCDLSELKPRKTDIDFQRCLYGPFLRQSTPERLAALTILTVVNLGAMSGMDRGVTVSRLVTNLARLVQEDIKLQRKEEARKAARKLKVSVRREAAEREKAEALNKTIEELESRLDEMGDEEKEEAIKDIKKMKRRAAYIVQAQKKAFEEGKPDPFEAKPLAELSASTQKMIPSMNQKPWSQDICSHVGSILLKILLETAKIKVTTRHPKTQELVSQYQPAFIHLQQPRKGKKVGVFMLNLQLAEKLKQEPIADFITKHLPMLVEPKPWTSFHSGGYLASETALVRVKSGNVEQTLYNKAAIETGDMTQVLKGLDILGKTAWRINENILRVMLKAWNKGDEIANIPPLNPKFDLPPEPDPSADPLKRLEWIHAVKFMQNKKMALHSQRCYMNLQLEIARAYRNQTMYYPHNVDYRGRAYPMPTYMNHMGADHVRGLLRFAKGRELGVRGLRWLKIHLANVYGFDKSSFDERESFANDNMENIMESVANPLDGSRWWLLAEDPWQCLAACFELKAAMDLADPTKYVSHLPIHQDGTCNGLQHYAALGGDIWGAKQVNLEPSDRPADVYSAVADLVKKAIDKDAELGEPFAKALQGKVTRKVVKQTVMTNVYGVTFNGAKKQVCKQLDDLYPTLGKDNGTSNMKLSMYIARLTFKALATMFRGAHDIQYWLGEVGGRVCRALTKTQLKLLAEVEEVGGTGDNDSLRSLRQAKLTELQTKLATEFRSTIVWTTPLRMPVVQPYRKVSTREVRTCLQAVVCATTDATDPVNRRKQLQGFPPNFIHSLDASHMVLSAVRCDEVGLTFAAVHDSFWTHAADVDTMNDVLRDAFIRIHQENVIGRLAAEFETRHKGSMYMAHVDSGSDLGRKIRQLRSQTRQSIEEELVLEYRRLRLLSSGDEKDRAKAQEIVTPASLYEAMPAKEPDIDIAEDKKNMGIGEIPADEEDDAALLDEVLGEVLSEGEPDEAGEEDVPSLEDDEEAPTPKKTTKAKKAKRKPRSKKKKGEEAEADEADEAEDAEAKDEDKKEADEGDVRKPSQKKRRVKGYTGRSIAFWMPLTIPPVPEKGGYDVNRLRQSMYFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5L9</accession>
    <name>A0A367L5L9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mediator of RNA polymerase II transcription subunit 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_4092</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Mediator complex subunit 21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5L9"/>
    <dbReference type="STRING" id="1330021.A0A367L5L9"/>
    <dbReference type="OrthoDB" id="526653at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.10">
        <property type="entry name" value="Mediator complex, subunit Med21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037212">
        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021384">
        <property type="entry name" value="Mediator_Med21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13381:SF0">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13381">
        <property type="entry name" value="RNA POLYMERASE II HOLOENZYME COMPONENT SRB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11221">
        <property type="entry name" value="Med21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="86"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI09711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="138" mass="15961" checksum="75E7939242A6B74A" modified="2018-11-07" version="1">MGDRLTQLQDAVDQLAQQFVACLHFVHRRHDLETLGPNDNIRDIKQEPHQKEVDPLPADEFQAGLKELSRDLIVKEQEIEYLISSLPGLENSEKDQEQNIRDLEEDLKTAEALRQEALREKDETLAQLDAVIRSIRRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L669</accession>
    <name>A0A367L669_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI09898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L669"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="221" mass="24535" checksum="32E71FDF71E8C1CB" modified="2018-11-07" version="1">MVPGRGLATTPFADAVIEMVLATAAPCTYPSRYYQELVRVTRIKLRGLTLSSDWAMVDSHERTEGYSGRLGQRQGTLPMSVFCRTGGCWVLILFIEPNREHVATLLGTALEPVLVWAAHPPARWTRQSAVVLSDLSIIPSLSYYYRSSFVLHHCWNKAGMCYIRRHHLRPAPTLGGAALVLLIVLLSRQEAEITASLRSSSSTTPHQPPSVFNHPPTPFPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L695</accession>
    <name>A0A367L695_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_8402</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI09939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L695"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI09939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="133" mass="14529" checksum="74C0D8A66EC5A417" modified="2018-11-07" version="1">MPVSSPGGTSLMMVLRVPMRSDWNLVFANEKRGGEFGCGGKANMRVAKANQTHGRKRHLGLNKNSHRLAPRNGRPSRGSMFRVVGSELSRSASLQEVGGEKKKPVAFRSGFRSPNGASVITRMHEGRRRSATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6P3</accession>
    <name>A0A367L6P3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_8423</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI09892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6P3"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI09892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="135" mass="15618" checksum="0DA1C58768339092" modified="2018-11-07" version="1">MTFSFPARSHMICALSCMHAWELTQRNIHTWLLRGMKMMMKMMMMMMTIMMIMSFCSSKNETLLHAVLRLDNVASKLTRNEDIQLNQLQMTQQFEKAVALLWLEKLGTSVYFPQVASSPFAHGKRDNFCEGGKPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7A2</accession>
    <name>A0A367L7A2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Potassium channel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_8550</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7A2"/>
    <dbReference type="STRING" id="1330021.A0A367L7A2"/>
    <dbReference type="OrthoDB" id="297496at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015271">
        <property type="term" value="F:outward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022841">
        <property type="term" value="F:potassium ion leak channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030322">
        <property type="term" value="P:stabilization of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003280">
        <property type="entry name" value="2pore_dom_K_chnl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003:SF342">
        <property type="entry name" value="OUTWARD-RECTIFIER POTASSIUM CHANNEL TOK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11003">
        <property type="entry name" value="POTASSIUM CHANNEL, SUBFAMILY K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01333">
        <property type="entry name" value="2POREKCHANEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5 8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="372"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="221"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="11">
        <location>
            <begin position="381"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="643"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="643"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="653"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI10289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="750" mass="84646" checksum="C6DAC5EAC860DA39" modified="2018-11-07" version="1">MADSPSSSSSDDGSDPLARVANSRLRPEFPLEARFQNDDAHLVPSRLWFASSAFPMVAGTLGPVASAFSICALVRQWRMHVPPMTDLNAAKFVPDPPWLLIINAVQLAVALVANLFLLLNMAKRVRFTIAQPITIVGWYISSILLIACLGAASGPLKHHLRPLNEYAWSQAFYYGIWAAILYFLVASLMLVTFWGAWSGHYDKDFNLTNSQRTLMLQTIAVLAYMLIGALVFSKIEDWPYLDAVYWADVTLFTIGFGDFAPKTQLGRGLLIPYALVGTISVGLVISSISSLMLERGSRRLDARMEEKRRRKVITSMTRKGDDHVLTPLPPAPPPDADDFRVDDPLGDEFDRRRCEFELMRDIQSAASAQRRWLAMGVSFGIWVVLWLVGAVIFYACELSYQHWTYFDAFYYCFISLLTIGYGDLHVVSSAGRSFFVFWSLLALPTMTVLISNAGDTVVKLINDYTNYLGNLTILPGDESFGRTMKRIVNSLSCGNLFKSVVNGRAPDRPRRPDRTNEKMATTTDHAYDDDAVDVQQMMMTTTTTTPPTTTTPAVSLSLSRQLTAVLGNSTNGVLIPQNTAERRSLTRVHEILGSLPKGNDFHLLLIAEIQRVAKHLREDEPRRYTFEEWAWYLGLIGEDERKPEMHRKAIPKEKRKHRRRHGHHPHKHKHARHHHHHQEEPRAADGEDDGVEEDDMLKWSWVGKYSPLVGGQEESEWILERLMMSLHESLWKTGLADEDDSSDSTATSQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7A4</accession>
    <name>A0A367L7A4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WHIM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_8448</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7A4"/>
    <dbReference type="STRING" id="1330021.A0A367L7A4"/>
    <dbReference type="OrthoDB" id="349045at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028942">
        <property type="entry name" value="WHIM1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42107:SF1">
        <property type="entry name" value="WHIM1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42107">
        <property type="entry name" value="YALI0D24453P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15612">
        <property type="entry name" value="WHIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WHIM1" evidence="4">
        <location>
            <begin position="163"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="306"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="508"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="353"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="443"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="467"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="552"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI10305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="578" mass="62806" checksum="076CF5D935F4B273" modified="2018-11-07" version="1">MTAESDSSDLSSLSSLSPVPSGDEADDVAPSDDAAPSDDVAPSPTVAKPGLLKFFSKQPSVPSRKRSPSPPHEYVLADNPDIAFIVMFRSRFSDAFPKSLAHFGPQELERDISDPVPGDRVEHFLCALLGLLLNRKQDVKPGHYGRALEDAVASHKNQWLPVWEDKSPLAGSTTFNSMSPTQRLTLLRALILWSMGSSEAVKGLLSQSYKQNRIEDDHNQPRSVRPWGSDGDKRRYFLIEGQDDTNFRVYRESNPAGLSRTWWSVAGSIDELRALADKLEHKDGGPKAKELSQKIISAIPRFEAGEEKRKRREYRQLRKDQLKRPDPGYSLYEGRTRGKRMKYTFSDEDDTLNSDSTTNRRSARTTGANTPAETGPVTTSSGRQVKVPPRLNMDVGASAPASVQGDVSEHDGEGSAAPRGRPKRSAAAKLVANGWGGAGPYGDTDDDASEVEFGDDEDDVDAHITEESEDDDEFDDDEIIVDEEAEIPPRTLVVKLSLATPKLKTALAPASPLQKAAVKAEAPPPPPAPVRDTISASSEAMASAKTVDKPESTNPASEQPNSATSLAVRASSEQIVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7B6</accession>
    <name>A0A367L7B6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1770 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8431</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7B6"/>
    <dbReference type="STRING" id="1330021.A0A367L7B6"/>
    <dbReference type="OrthoDB" id="2430343at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140580">
        <property type="term" value="F:mitochondrion autophagosome adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013898">
        <property type="entry name" value="Atg43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38699">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38699:SF1">
        <property type="entry name" value="MITOPHAGY RECEPTOR ATG43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08589">
        <property type="entry name" value="ATG43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="149" mass="17225" checksum="46787DBD4E520CE4" modified="2018-11-07" version="1">MESFPSELAATVQAGHIRKDPDPRLDIAPSTAAEKKQALTVEEDDHEDIPCSVLRPTPRRRNLPPLPDLRFEQSYLHSISNADTWWKVMLITVRDQMIMPLAQGLIYNLVLNGWQYSRRNTRFHGTSSGARLRRWWYGVNNWAIPSSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7F0</accession>
    <name>A0A367L7F0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_8594</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7F0"/>
    <dbReference type="OrthoDB" id="4919761at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF43">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="135"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="329"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="469"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="534"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="45"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI10162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="560" mass="60017" checksum="B800A97D06DE606A" modified="2018-11-07" version="1">MTSPHDALELEKYTHTDPPLIERRESSGDADKAIVYVHGLRFWLLAITISVMLFLASLDTTITTTSLVAITHDLGGFQTASWILSAYQLGWVAVIVICAKLSDIFGRKPVFIASIAIFAIFSAGCAAAQTMAQLIVLRAFQGVGGGGCLALTTIIITEAVPPEKLGAFASKINVALIMSLVLGPVLGGAISSGTTWRWIFIINSPTDRAMPSSIPMSIIAGVLAQVGIPSGFPHHGQSTSSKSLGSSKVKKLARLDLLGFVLLILAALSFTSGFQEADSRFAWNSVYVITLLVVSLALWVVLLIWERHLTLYSRAREPVMPWRFFNDRVRAGVMLVFVLVGVPIVVTNFQLPQRFQLVNGLSSIDASVRILPFGVAFCVGSLASSRLTSSLRVPSIYHVLAGSALQVVGFALLGVLRASPDIQPAVYGYQVLCGIGVGLNYMALYLLIPFTADRRDKAIGMGLAGQFRTMGSAFGLAIVTSVFNGYTGHRLASLGLSPDVTSIEGVGSQRLAAISPEVLADVRTILSEAYNRQMFVLCAFAAAQIPAVLLIWKREQMVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7F3</accession>
    <name>A0A367L7F3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BIR-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_4377</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7F3"/>
    <dbReference type="STRING" id="1330021.A0A367L7F3"/>
    <dbReference type="OrthoDB" id="2196114at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00022">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1170.10">
        <property type="entry name" value="Inhibitor Of Apoptosis Protein (2mihbC-IAP-1), Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051190">
        <property type="entry name" value="Baculoviral_IAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001370">
        <property type="entry name" value="BIR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46771">
        <property type="entry name" value="DETERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46771:SF5">
        <property type="entry name" value="DETERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00653">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00238">
        <property type="entry name" value="BIR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57924">
        <property type="entry name" value="Inhibitor of apoptosis (IAP) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50143">
        <property type="entry name" value="BIR_REPEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="207"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="254"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="334"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="401"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="468"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="525"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="558"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="585"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="614"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="637"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="667"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="681"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI10357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="791" mass="85264" checksum="AC0EAF528D927C01" modified="2018-11-07" version="1">MDSAKLQQYVVCEARLASFQKIVKKRGSSAGGRAKTSNTWPHKQIAPASLAKAGFFFDPTPASPDNVVCFLCAKPLDGWEAGDDPLLEHLKHAPDCGWATVAAIEADVGDYGTQDPISSQMIEARKATFGDWWPHDGKKGWKCKTKQLADAGWKYTPTADSDDMATCAYCQLALDGWEPGDKPYEEHFNRSPNCAFFHLINQFGGAKKRAPRGRAARGSKASRMSAQSTASERLSTSDTTATADDSLLTTASTMTQGGKKVKGKKATAFSKTSRSKAKKNDVDESEVVDDEPTMPRPKPAKAARGRKRGSDAVEESNASILAPSKKRATRTRRSTVTDTSTVVADDSELVEPTHKTANRRGIQTSQSEASRQASAVSLVSSASFASLRAPTEQFPDDDEIERQLEADLERDWDSDEEQDHLGPKDVASADYIMLDPHPVETDDDAVEEELRTLQAEMRVDEPEQQLHVPKKGRKAGVRKASSKQNKPSNRVKAAAAAAAASSVEEPRPQEEEETHDVSVGSTDTVVKKAASESKSKKKGRGEKLPPGSRSSDAEEAPSRPSQSRQSQETRTSVEIVSEAGNGASPEDDQPAEDGEVEQLQVEEARATEPLADMNPSSGGVTVLQQTTHQPSTPVISPAPSARQPALSPSPSPQSSDAENRPPSSKPATSSGKGAGTTTTTVPLNQTPGSPSKRNMLVGLQTSEPWTAASLDLLAILEGMTPPPRNEGSDDKENPRAFHLSTPEKAMTVEEWIYFNAGQAEARLKHECEVMVSRFEREGTRAIRALEGLSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8W0</accession>
    <name>A0A367L8W0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5191</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8W0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI10861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="187" mass="20196" checksum="CBC4F813D7D181BA" modified="2018-11-07" version="1">MRLGILPLTAAVTSPTSISPTSTTPTHLPIAISGDDVIYFPTDPVKHTSNKSGKTNIVTAEVVHPVAPTPLGANHTFDYTTTTTTTTTLVNIRHARRGLIYHQSPNQTVTVNTTTTYTVPLHPSSIFPTGDVTPWNPFTTSTKPTGRLLPTQGEAVRKMTKAWLDICFPIYLCDDAGCIPVVMEEPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8W3</accession>
    <name>A0A367L8W3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5193</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8W3"/>
    <dbReference type="OrthoDB" id="5372935at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038883">
        <property type="entry name" value="AN11006-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42085:SF2">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI10859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="36294" checksum="CCF268FCA1E86449" modified="2018-11-07" version="1">MTRRPVKASALRAAVATRMTTPLSSATNTPLSSTYPSTCASEAETEDEVTALKKARKIRRPTKPFPFLDLPPELRIQVYEHYFKDTDAVLDLGPDNYKRIHKLLGLMRVCKLLHSEATHFFYSSRSFRLFPTYPGRYFKTKKPLLARLKPNQRECIVSLELRFGPGWNAPPRGWAVNDALGLHDCVNVQKLQVFVECDPSDGVFKGFRRSENFYEAFSRNLLAAVIDALPAVRCVEFDAWSSVKKSGAMIRSLVDFDAWSSVKKSGAMIRSLVDVAAQSKLLIRWGPERGWTDADDTVVDSAVAAGPVSFAGSVSIQGYAPDVLAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L904</accession>
    <name>A0A367L904_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5394</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L904"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI10905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="114" mass="12024" checksum="CFC792AC950D6098" modified="2018-11-07" version="1" fragment="single">SELLYFIRARTADTSSLTLDSSVVVPTQEARMLSTCVSAFGPNSSSDRTPGRAALILARTRPPNTYSSAAPALASESLLLLGSRPGPLLLHLYNVAIAIAVIVARGGPRPPFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L958</accession>
    <name>A0A367L958_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5371</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L958"/>
    <dbReference type="STRING" id="1330021.A0A367L958"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI10963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="113" mass="12763" checksum="7829427634EFEF76" modified="2018-11-07" version="1" fragment="single">KIRTDKATFRDKEDRIGFLFRSLEGKARKTLETYLLTKTKDDSLSYEDFCGYIKDSAVKRLDAELVLVSLVPLVDFQGRLASSPNDLPALAKYSLSILLPKTPLLNRQIDLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9B3</accession>
    <name>A0A367L9B3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Conserved oligomeric Golgi complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_5254</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI11015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9B3"/>
    <dbReference type="STRING" id="1330021.A0A367L9B3"/>
    <dbReference type="OrthoDB" id="18786at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019465">
        <property type="entry name" value="Cog5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048485">
        <property type="entry name" value="COG5_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049176">
        <property type="entry name" value="COG5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13228">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13228:SF3">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20649">
        <property type="entry name" value="COG5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10392">
        <property type="entry name" value="COG5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 5 N-terminal" evidence="6">
        <location>
            <begin position="34"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 5 helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI11015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="453" mass="49249" checksum="623E43C650A9CA61" modified="2018-11-07" version="1">MAASGPGLDPDAGPGPGPGPDDEDTDPPSYVDYETFLAPDFDPATFANSLVIATNNPNDSPLDLSTPLSRVLFDAQELDTHIDLVATRHAVPLLKHTQAQNAASQRIFDELDPRINSLNESYRQLEKDVIVKHAEADEVRHVALRLWETLRLARAAARCLQLGRQLELQHAGLADDDHGALVRCANTILALREVLEYQAPDEEGHGLDKLNAIRSLEESALTPIQRSVREAADRIVRDLSIPATMTFAQAAEARARLESALAALNLLSPTLGVDLHHWTPRLLMQAIEAYVRSALNTSLSSLSRALGQLPTIDRALAEVTARCQNLVSLEFILQSTSPPDHLLLPSEAQKPLSLVQPVLAHLETTSLASYFWRNLAGSFASRVQELAGRPGAVNRALRANKNVVGDAIRQAVLKGCQLPPALVDVKSRGRTADTNWDREAAVMVGSFVNNLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9C4</accession>
    <name>A0A367L9C4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_5246</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9C4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016893820" evidence="2">
        <location>
            <begin position="27"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI10832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="188" mass="20363" checksum="D70891BD37AFDBF5" modified="2018-11-07" version="1">MLYNRWTVFLLSVAALLFLWPGSSYGAPPGIGSSRGTYNINPRPNPGSSNRDGSSGHGGSDSPFSSRDSSRHSSTTSLSSYSSSSSRGSFASGSGRSWPPSFDDAVFPGRNPGPPPAYSQRPRLLRSGPAGAPPRNFDPPPPYDDGKDAKSKVDGMRRLWFCISRSWGQLKSKTIEPITFELRYEQDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9F2</accession>
    <name>A0A367L9F2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5444</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9F2"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI10862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="66" mass="7407" checksum="ECB38D24CCC9074F" modified="2018-11-07" version="1" fragment="single">AIAQSSRLKHKLLLPGSLFNGDKILFLASDIIKQHCVDSLCYKYAFLIGKRALAASTRLGFPFYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAF3</accession>
    <name>A0A367LAF3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7464</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAF3"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI11395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="78" mass="8358" checksum="F10C31CD6E80718D" modified="2018-11-07" version="1" fragment="single">AYTEADCIAKEGTPCLLPDLPYVPSFVRPVRPVRPRAVAASYVVVPFLPLLCDVRRPRAGCSRHGVTVSGAPAKITLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LB85</accession>
    <name>A0A367LB85_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dynamin GTPase</fullName>
            <ecNumber evidence="2">3.6.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L249_7351</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="2"/>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LB85"/>
    <dbReference type="STRING" id="1330021.A0A367LB85"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1240:FF:000002">
        <property type="entry name" value="Dynamin-1-like protein isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000383">
        <property type="entry name" value="Dynamin-like gtpase dnm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF235">
        <property type="entry name" value="DYNAMIN-RELATED PROTEIN DNM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="14">
        <location>
            <begin position="27"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="13">
        <location>
            <begin position="710"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="528"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="642"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="528"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="661"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCI11675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="797" mass="88147" checksum="F88C6D6EDA549323" modified="2018-11-07" version="1">MAALGEDLLGTVNKLQDLVFNTIGNDSLDLPQIVVVGSQSAGKSSVLENIVGRDFLPRGSGIVTRRPLILQLINVSDDDEAPDAPDTLRSSSSARRSEWAEFHHIPNRRFTDFSDVKREIENETSRVAGNNKGINRQPINLKVYSPHVLNLTLVDLPGLTKVPIGDQPTDIEKQTRNLISEYIAKPNSLILAVSPANVDIVNSEALKLARHVDPLGRRTIGVLTKVDLMDHGTNALDILSGRVYPLKLGFIGVVNRSQQDIQGNKPMEEALKAESDFFKHHPAYRNISSRCGTHFLARTLNTTLMSHIRDRLPDIKARLNTLMGQTQQELASFGDMHFSGKEHRGSLILQLMTRFANSFIASIDGTSTEISTRELCGGARIYYIFNSVFGSSLESIDPTSNLSTLDIRTAIRNSTGPRPSLFVPEMAFDLLVKPQIKLLEIPSQRCVELVYEELIKICHTCGSTELSRFPRLQAKLIEAVSDLLRERLGPSASYVESLISIQRAYINTNHPNFLGAAAAMSNVVSAKQERERKRFIQEERERREKKRAKESGANGVEQQPEEGDEPVASDRGEVGGGRRHGGKQPRSLSPTVNDRGHGSLAAAVNGARPHSPSRLNGQGIGGARDSFLNYFFGKEGMAPPHTLSSGQVGTGRHLSPAAEPMARREEKAALRPAPPREADEYDTMGRSYGLASHLGESNEPALTDREAMETELIRALISSYFNIVRESIADQVPKAVMHLLVNHCKDVVQNRLVSELYKESLFEELLYEDDGVKKEREKCEKLLQTYREAAKIIGEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBL5</accession>
    <name>A0A367LBL5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Inhibitor of growth protein N-terminal histone-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_7374</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBL5"/>
    <dbReference type="STRING" id="1330021.A0A367LBL5"/>
    <dbReference type="OrthoDB" id="2505961at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16858">
        <property type="entry name" value="ING_ING3_Yng2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF100">
        <property type="entry name" value="CHROMATIN MODIFICATION-RELATED PROTEIN YNG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inhibitor of growth protein N-terminal histone-binding" evidence="4">
        <location>
            <begin position="25"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="139"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="222"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="84"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="333"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="344"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="379"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI11819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="425" mass="45499" checksum="E36C1F31D838B6ED" modified="2018-11-07" version="1">MPRDDLTIDFVKKMPQAEPLDPALILDDWTNRVQNLPEEIRFMQDEIADKDRLYHECIRSIEDRDDKIQKWIKSNGSLELNPKEDILRNQIREYYARADELSREKIALAQRMQVILDKHIRSLDVQVKLLYDRGEPSFTDPDEVPSLLRPSAANHAAPSDRSVNPAAGATAGAGTLSGPISSPSNPAVNASNAYTTRLPAHQQIRIAQAQQAYSLHAASAPATPATGIVPSRQRETSAGPATKRGPRSNAGPANAPTASSGLSRHSSLGPGTPKSGPAAGPVGSIARAGSVGPRAGSVKGASGSGSRRGTPTTAPRKKTAHKSSLSRVKKVSARNSPVSTADSDLSEAESVSADDEDVHEARSRGTPAVDSKNTNVDEVVGDAEDDEEEGGDDKKYCLCNTVSYDNNNRGWMLKFIGQPGTMSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBS2</accession>
    <name>A0A367LBS2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000009">
        <property type="protein sequence ID" value="RCI11867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBS2"/>
    <dbReference type="STRING" id="1330021.A0A367LBS2"/>
    <dbReference type="OrthoDB" id="9973183at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="136" mass="15368" checksum="77142BBF3FB2AC96" modified="2018-11-07" version="1">MSSSLSGETPSGKTATKRLLKELDAWRREQGGREKGIERLGPAWTPAYSVLECVRALRFLLACPEVDSPLNVDVAALLRQGDVLGARRLVECWALDDEDFSFALAFFSYTHHPKLLIVRRQLDTWRNRHVFHSSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBT2</accession>
    <name>A0A367LBT2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_4181</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000009">
        <property type="protein sequence ID" value="RCI11875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBT2"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="9"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI11875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="404" mass="44887" checksum="7DA530D3C6A3497C" modified="2018-11-07" version="1">MLRYSFALRSRSGLQRQQQQQRQQRQQTQKDHLITGCQEGGRTRGPRQQTSRPSSSPSFLRQGSQRPILRSFFSTFAADTATATATATANALVATVPLLLLLSLSNALFGPIFSAAFFVLWFSVLFFPPSSSYGRPYDLQRRQEQGQDQGQDQDQDQQQNTGTGREQQSQQPLRQPLQQPLQQEQRQQTIVPTAVPYLRPPQSLPSSSYSSFSSSSLPGLSSSSSLPGLSPPPSLQSLSSSFSSSSSSSFPSYGPTPPLRPFQGRGIQQFLDQFEEKVPERRVDWLPFFVAPPCLRQIQIRTVGYFEKLRRHEARRPKTKDTIDWLEKHAFFCRKVGPGPGPGPGPDESTEHSYGLFQALPKEIQRLYVTTIGGGYGYGYGYGYGYGYGYGCTGRTGPIQSASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LC14</accession>
    <name>A0A367LC14_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RNase P subunit p30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_4590</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal RNase P protein component 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000008">
        <property type="protein sequence ID" value="RCI11954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LC14"/>
    <dbReference type="STRING" id="1330021.A0A367LC14"/>
    <dbReference type="OrthoDB" id="17948at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002738">
        <property type="entry name" value="RNase_P_p30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13031:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13031">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01876">
        <property type="entry name" value="RNase_P_p30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="PHP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="249"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI11954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="31876" checksum="BDB7E0966F88BACD" modified="2018-11-07" version="1">MLYDLNLPWSPATPSDRLSQTLSLASSLGYAVVALNHSLELPLPAKPAPPPFPLLSVPGSDAASESPRVLRRATLKLADPAAFNFRLPALAAVYDVLAIRPLTEKAFQNACLSLEVPLISLDLTTHFPFHFRPKPCMAAVSRGVRFELCYAQLLAADSRGRANFIANVAGLVRATRGRGFVISSEANFALALRAPADVVNLMSVWGLASEKGLDGLRCVPRSIVVNEAIKRRGYRGVVDVVQVASRKVETADSPDGDSAATTTSQKRKVTDVPSMSKRKAKKLKMAARATASEITES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LC22</accession>
    <name>A0A367LC22_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ras-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_4578</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000008">
        <property type="protein sequence ID" value="RCI11967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LC22"/>
    <dbReference type="OrthoDB" id="775356at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21206">
        <property type="entry name" value="CH_IQGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05127">
        <property type="entry name" value="RasGAP_IQGAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.506.10">
        <property type="entry name" value="GTPase Activation - p120gap, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000593">
        <property type="entry name" value="RasGAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001936">
        <property type="entry name" value="RasGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149:SF14">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14149">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00616">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03836">
        <property type="entry name" value="RasGAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00323">
        <property type="entry name" value="RasGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143885">
        <property type="entry name" value="RGC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50018">
        <property type="entry name" value="RAS_GTPASE_ACTIV_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="3">
        <location>
            <begin position="260"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GAP" evidence="2">
        <location>
            <begin position="1010"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI11967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1646" mass="187340" checksum="882473103A59D385" modified="2018-11-07" version="1">MSSQRKPDLAPLPHDILTRYPSTTTTTTTTSDNVTKTPRQHRRGQSHVLARARTFEAGAAMDVSLVSPGSLRGPNRQSLCLLPQAPASSPPRPPITPPGRKVSRHERGKSIDVSRLASSLADGPASPVSPSPPRPKSARPISMLLTRSDSGLATSAATPKTNASPQPLHHAHIGRPDLELLGKSSTRELRTLSRLAQSESADDFTITSPAQEVVGLRGRRRLQRMDKPTGGRDSRTAAYSWEGRNWMDKQRQFLQAYEYLCHIGEAKEWVEDVIGKSLPPIVELEEALRDGVTLAEIVEALNPDKRYRIFHHPKLQYRHSDNIAIFFRYLDEVELPDLFRFELIDLYEKKNIPKVIYCIHALSWLLFRKGIVDFRIGNLVGQLEFEHHELEAMQKGLDKLGVNMPSFGNMGADFGVPEPEPEPQETEEERIDRELGEVKESIVDLQAQSRGAILRMRLGSTMQGLWDGEDGLIDLQARIRGDFTRQIMGYRLQMRRSAVLVQSAVRGFILRRRLRQNDQSRKASEPLILSLQSAIRANRVRVELGDTKSLLGACKGPIRDIQSTSRGFLFRKKHAAQRRETQMTSGPVRSLQACARGMLLRARVDSQLRLLDEQAGVIADMQAAARGLRIRRRVARELDDLRAFDSAWTTFEAVARGAAARGRCSATKAELEQQAGGVAQLQSLIRGAAARREVAARLDELESNSGDIVAIQSHVRGVLQRRDVDALWRRLGRHVVQTVDLQGYARGQLARQRHEALMDELHSHDAATAAFQAILKAMIVRARVEDLVAELMEEEESIIFAQAAAKGFLVRARFEEKKRYFDENMQKVVKIQSFVRAKVQGEAYKSLTTGKNPPVNAVKNFVHLLNDSDFDFNEELEFERMRKTVVQQVRQNEMLEQYIDQLDIKIALLVKNKITLDEVVRHQHNYGSSSVGLLANSTMSSGNQFDLKALNKSSRKKLESYQQLFFSLQTQPQYLARLFKRLREQGTAEKECKRIELLIMSLFGYAQKRREEYYLLKLIARSIREEIEGAAILHEYARGNYFWARLLGNYTRSPRDRKYLRSLLGPLIRDNFIEDPALDLESDPMQIYRSAINNEELRTGRPDQRPLDVPREVAIRDPETRRLFIDHLRDLREICDQFFTALEDLLHKMPYGLRFLSGQMFDALCQHFKREPQGQLLQVVANWLWKFYLQPALTSPEQVGVVERTLSPLQKRNLGEVAKVIGQVASGRPFGGDNIYLQPLNAFVTESMERLQLMMRELMAVPDAERTFDIDEFNDLYAKNKPTLYVKMTDIFAIHNLVAAELATMCPTRDDVLGEIMSDLGSAKSNENEMNAAGSSDIHMFLTAKLHDVEDPEEDVKALFMETKRCVLYIIRVQTGANLLEILVKPITAEDEQRWQALLRDDFSDGSETRGAYSDANMADVTRMTYHELKRTALENVMRLEQMGRISKHNLYQDVLNAIASDIRTKSRRRVQRQRELEGVRLTLGNLHEKAKYLEQQRRSYDDYIEHAMATLQNKKGKKRFLLPFTKQYNHQRELERSGRVPKFGSFKYSARSLTDKGVLVSWSGLGDRDVDKINLTISCDEVGIFALEGSRGHIQMPGASALVSIEDLLQAQFESHQFMHVFEGNLKLNVNLLLHLIYKKFYRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCD8</accession>
    <name>A0A367LCD8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Kinetochore protein fta4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_0559</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCD8"/>
    <dbReference type="STRING" id="1330021.A0A367LCD8"/>
    <dbReference type="OrthoDB" id="21214at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031511">
        <property type="term" value="C:Mis6-Sim4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025207">
        <property type="entry name" value="Sim4_Fta4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42040">
        <property type="entry name" value="INNER KINETOCHORE SUBUNIT FTA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42040:SF1">
        <property type="entry name" value="INNER KINETOCHORE SUBUNIT FTA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13093">
        <property type="entry name" value="FTA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="141"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI12098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="267" mass="29269" checksum="A2155B141272F465" modified="2018-11-07" version="1">MVKAPPPTVSSLKLDFLSSQASALARPSTAPSQSWLAAHEASDQPLPGRAVGDAIIFVGIAIQQHSRRVYHPQANRHVADQISDVYAREAERRVAAAQAEVDALAVGKGLDLVDDDTIEILPPTWPVQRQVSDDPLEAERYADTVARLVQLNQERRRLREQVETLRQLKETVDPLSKQVQENLVTRNGPVESELEKMRLLLARVAGRVSELPDVRPTGPTREEEEEEEEGGVDVGDLAQTGGGKRVTGGGKRVVTLDEFFSEGGMMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCJ1</accession>
    <name>A0A367LCJ1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_0576</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCJ1"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI12135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="101" mass="11740" checksum="CBCFA4DA6BCE8D41" modified="2018-11-07" version="1" fragment="single">GRVDKGKKKKRSFFLVAPDGKVRLSFHKRIDEQTYRWRWITKGRTTTTWEALIMAAKQAFSLKRVSHVPGFSLVDGKGYMALLDLCYAFVGEVVTLDSWRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCR9</accession>
    <name>A0A367LCR9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_0851</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Forms homooligomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SHO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCR9"/>
    <dbReference type="STRING" id="1330021.A0A367LCR9"/>
    <dbReference type="OrthoDB" id="5983572at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007232">
        <property type="term" value="P:osmosensory signaling pathway via Sho1 osmosensor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11855">
        <property type="entry name" value="SH3_Sho1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000213">
        <property type="entry name" value="High osmolarity signaling protein SHO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035522">
        <property type="entry name" value="Sho1_SH3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735">
        <property type="entry name" value="FCH AND DOUBLE SH3 DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735:SF20">
        <property type="entry name" value="HIGH OSMOLARITY SIGNALING PROTEIN SHO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="8" id="KW-0346">Stress response</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="36"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="13">
        <location>
            <begin position="253"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="211"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="211"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI12207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="312" mass="33768" checksum="8F8D5209EE4FEC92" modified="2018-11-07" version="1">MPPYGSLDSPSMSKMEHSRTYARNGVRLGNILGDPFALATLSISILAWLITFISCIISQVQPVPRDETSFPPFAWWAVVYSFFLIGGIFVVIASDAVHTYHVAITGYLAGGMVLVTSGVNSLVYSKSGAREAAAAGFILLSMVVIVWILYFGSTPSATPRAFIDSFALAKESSAMQGQPMNAYGSGRPETSNSVQPPQMYTSAQLNGFENSSPMGNVSQANGGRNSSGPMGYSTTTQQHHTKSHDVEVVAPTEYPYQAKAIYSYEANPDDANEITFVKHEILEVSDVSGRWWQARKQNGEIGIAPSNYLILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDN9</accession>
    <name>A0A367LDN9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nineteen complex-related protein 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_0477</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDN9"/>
    <dbReference type="STRING" id="1330021.A0A367LDN9"/>
    <dbReference type="OrthoDB" id="429427at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071008">
        <property type="term" value="C:U2-type post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012890">
        <property type="entry name" value="GCFC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028211">
        <property type="entry name" value="Ntr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12214">
        <property type="entry name" value="GC-RICH SEQUENCE DNA-BINDING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12214:SF0">
        <property type="entry name" value="LD29489P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15458">
        <property type="entry name" value="NTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="218"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="415"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="149"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="164"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="260"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI12352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="455" mass="49244" checksum="67DA3E85DF046E31" modified="2018-11-07" version="1">MNFSASRRKARVVGGAEEVENAEDSKAMPGNSAEPVRPLFGSRAGRKPFRQSKLRNSYSHEDETARNEGSSAADDSDGPVVIRPNVSRLSSGRLKKNKPTASKLSFATEAGESEVGTAGEAGAPSKGISGPKTTKRGVPLRGLPMRLPQESDDRPKYSKESLKELQSSTPNTPRDISSLHAEDGAEMELDASELEGALIVDSPTAKLREPATRILSDAEIREKKERRVRLAKETDFLSVEDEDEDESGGQKTKSSRLQAEEEDLGEGFDDFVEDGGLSLGRRAEKERRKRERRQMAELISAAEGHSSDSSSDSDAERRIAYESAQTRAGLDGLNKPSKTPRDEPPQAPPKITPLPSLAECLARLQDRIKDMERDIKVKDAGARQLRKEKEEVAAREVELQALLNVAGKKYQEAMGGRGASVGEQGVVPELGGERGLESLGTTPGRSAGSEDVEMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDP3</accession>
    <name>A0A367LDP3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Complex 1 LYR protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_0292</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDP3"/>
    <dbReference type="STRING" id="1330021.A0A367LDP3"/>
    <dbReference type="OrthoDB" id="4918505at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Complex 1 LYR protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI12545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="162" mass="18436" checksum="74AD3EE9E7CA7B3F" modified="2018-11-07" version="1">MPPPSRPNLQPAQSLKHFLQRARVLSLYRTMIRGTARITNAQTKAETRKLLRDEFERHRHLHDLCSHRFLMALCTFIPRTCPIPIRILVIVIVVVVVVVVGTSSQRLLTPQPKGRNSRTAPAPPPSRFGTTDDAGTQQSARRSDDDEGEKKEAIRRRWAGWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LE45</accession>
    <name>A0A367LE45_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_1007</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LE45"/>
    <dbReference type="STRING" id="1330021.A0A367LE45"/>
    <dbReference type="OrthoDB" id="2988756at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF2">
        <property type="entry name" value="SRPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="21"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="327"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="371"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI12686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="380" mass="42418" checksum="24E4479CBFC6032D" modified="2018-11-07" version="1">MDSAATEGLVYFAIEAFLILLRFFMRWRAQTFRRLAMDDYLMVFALLLDIAGTVASSVVVFGAHGLANSGYGDLENKNRKSRHSMTAAERASLSPDSPEFRIRVQGSKAHLVGWTSFAALLWCLKLCWLFFYKRLGHRVHHMALKVNIGLGFCAVTFIALFCVILFGCVPFEKSWQINPDPGSMYSVVVMRLQQSADRTKSDFCYPASSRLQAWVMLVCDVATDLYITLIPLPMIWHVRIPKVYKVGLIIMFCGGILTMTFSIIRCVMILKSNEASTEFAAMWSDREALIAVIVTNVPVLVPLIRKMFWNISDKSVSSVSRTALESRPVHDMSRARGLQESGRVSTSSLPTKVPTASAESFYDSESDGADGSSTRNGRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEC0</accession>
    <name>A0A367LEC0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_0953</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEC0"/>
    <dbReference type="STRING" id="1330021.A0A367LEC0"/>
    <dbReference type="OrthoDB" id="4096268at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051176">
        <property type="entry name" value="Cent_Immune-Sig_Mod"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 170 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15715:SF37">
        <property type="entry name" value="LD47843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="57"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="706"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="710"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI12773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="764" mass="82064" checksum="0274621077F5A2CE" modified="2018-11-07" version="1">MAPSNADEGELSRRKHQSSPRFSTDAAVAVRVILSPSRACKDYLDRNLVLTMDRSDVQIGRMSHRNPGLHASSTNAWFDSPVMSRQHAMLHFDSDETVRFLFLSIPLSSPADMCRQKLYIQDTGSLHGTFQNGIRLSPTTLHQLNPYDELCFGTTVDRNTDIYPPCTMVVTFEFVCTDREQANPVVYRISDDSDVEEIACLTRPQTKPVVYRVPDYSDVEEISDDDEEEEDDDDDEEEDSSIRGSIIALRRNGKVKPVHKIPDELLSALSMTEHRLAEAPASDDEDELPLSAMPPKDHTGEKERCESEWQPSSPTVYSADDEKRDAAHHVKLYPAECEEDDTTSSEWEDCSSSGRAPVASPRFPSALPASWETEGLPSSTNSSRSVFGTHQGTERPNERDSMSPVLQGAAVLPSISASPPPNGKEVKKSRDFDERESSKMKGSANFCDPANTLVSGECRGVIASRVPKPVPAMAIFSPPPPPRPASLSRGRSAESAAQALGEKTGKMAYFAARLGNRRFLESAAKDLSVAGLAAGEGHCEVESVTDKDEGGSGGDGSGHCSLFGLSIGSAHPLEGPPTTSLLASGEKFLSSPLLEPEAPVRPPRESPDLNETSAYQFLLSKANAAISKHEAAKDEAAAQQKAVTKEHDVAVVKQAEAAAKHGSAVNKEAHDQGTTSLVIVDGEQAANTQKGSWRKRKAGEMSADLGDGEAATLAPTPSASTTTGTGKDECRTVKRLRLAAEVLGYAALGGVAVVSALIATAPSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEF6</accession>
    <name>A0A367LEF6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_0898</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC35F solute transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEF6"/>
    <dbReference type="STRING" id="1330021.A0A367LEF6"/>
    <dbReference type="OrthoDB" id="429955at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009262">
        <property type="entry name" value="SLC35_F1/F2/F6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052221">
        <property type="entry name" value="SLC35F_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14233">
        <property type="entry name" value="DUF914-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14233:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06027">
        <property type="entry name" value="SLC35F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI12800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="406" mass="44612" checksum="0906229085AC15C9" modified="2018-11-07" version="1">MTSPKTATTPIQDDDPPSQHQHPHPHQQESQTETGLALLESRRPKKWYAYVSTPDFWLVVALGQVLSLCITATNTFTTLLAKADFNAPALQTCFNYALVGSIFTTILLVRDGPRVWYRVVTSRGLRYLALALLDVEANYFTVLAYQYTTILSAQLINFWSIVCVVVASALFLRVRYRPQQLLGIVVCCAGMGLLIATDHLGQRNGGPASDPLRGDLFALLGATLYGLSNVLEEWLVSKDPAHHVLAFLGLFGLVINGVQAAIFDRSALAAAQWSPHIAAWLVGYTLCLSLFYSLAPLVLRMASAAFFDVSLLTANFWGVIIGVRLFGYAVHFLYPLAFLCIVAGLVLYFVAGSLLGDARKPWLARDQHDGVAGLGTAKLRAINAARHHERPPEGLRDRLRRMFDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEJ3</accession>
    <name>A0A367LEJ3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_0623</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
            <orientation evidence="1 11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the complex I NDUFA13 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEJ3"/>
    <dbReference type="STRING" id="1330021.A0A367LEJ3"/>
    <dbReference type="OrthoDB" id="3308at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009346">
        <property type="entry name" value="GRIM-19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12966:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12966">
        <property type="entry name" value="NADH DEHYDROGENASE UBIQUINONE 1 ALPHA SUBCOMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06212">
        <property type="entry name" value="GRIM-19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI12845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="51" mass="5695" checksum="A598EBFB72785114" modified="2018-11-07" version="1">MAQDMPPRGGYAPVQYKRNLPAKGFRPGWVLLGIGAIMTYGWYKLVHGMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEM9</accession>
    <name>A0A367LEM9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_1080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEM9"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI12870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="112" mass="12290" checksum="FC2D063CB4D1AB9B" modified="2018-11-07" version="1">MQRIFESDSPSLMEKAYYVGRTVPLNDPTAGIVNASLGESVYNHSFTAPSAGFRLSSSPEYVIEKPLPISQPTTFRFPAHPLHVILTYSNLAVENGHRTAYLFNGSSCALQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEY5</accession>
    <name>A0A367LEY5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CDC20/Fizzy WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_0268</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEY5"/>
    <dbReference type="STRING" id="1330021.A0A367LEY5"/>
    <dbReference type="OrthoDB" id="10263272at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000098">
        <property type="entry name" value="WD repeat-containing protein slp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF8">
        <property type="entry name" value="FI02843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="9">
        <location>
            <begin position="261"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="389"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="520"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="104"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI12980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="583" mass="62658" checksum="C2B682272B178F3D" modified="2018-11-07" version="1">MATASVSTPIKSHRGLFSSKTAGGRMPLTPSPRQPSTTAAVPVNLGSSPLSPETRSANDCRVASITACSGSLMSRLRESPKSNIARDAQTPRKALELGVSDFTLVGTGKTPSSSKSKKRPLRQKSTKTTLSYGGDRFIPNRGSSGSSGSNKLGLRNKSGENSSVLSAAAEDAAAALDRLNINDDGAENYSRPSPNTAAYQDSLADACGVNLSTRILEFKPAPPESSKPIDLRQQYNRPLKPAGASSAQLRRRIPTAPERVLDAPGLIDDYYLNLLDWSSENQVAIGLERNVYVWSANEGSVSCLSEAPADTYVSSVKWAEDGYYMSIGLGTGEVQIWDVVKGIKLRSMYGHDTRVGVVGWSKHLLSTGARSGLVFNHDVRVKEHKVAELVSHTSEVCGLEWRADGQQLATGGNDNLVSIWDARSLSVPKFTKTNHKAAVKALAWCPWNMHLLATGGGAYDRHIHFWNSSSGARVNSIDTGSQVTSLRWSQHYREIVSSSGFPTNSLSIWSYPTLVRTVELNAHESRVLHSCLSPDGQMLATAAADESLKFWKLFERKAGAAGGLSGVAAGAKVADRTKQMTIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFI9</accession>
    <name>A0A367LFI9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospholipase D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_0640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFI9"/>
    <dbReference type="OrthoDB" id="4907280at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016752219" description="Phospholipase D" evidence="2">
        <location>
            <begin position="23"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI13157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="345" mass="37997" checksum="A036905BFC8B9F6F" modified="2018-11-07" version="1">MRLLGLISVLLTVVLWPDSGAAIPAPPAHTSPATPTFPVPPTSHTSREISSASAAASAAASPASAVVGAAKPFYAIAHRVLDRAGIDAAISHGANAIEIDAYAWGDGWYADHDGTFLSTGDSMRDMLQHVAIKNQEKRKLAFVWLDIKNPDWCSNDEQSHDCSIEALRDLARATLGTAGVQILYGFYTKNRGRAYNVIRDGLRHDEAIALEGDADTAQRIFEEEGPGDVRQRVYSRGYFNWTLMWPSDYRAMLDNLRKARLSGAFGHVFTWTAFEHKTYFLNKPDDPIQDVIKTGLVDGVIYGRPASQYKNERGSSWAIDQLKNRTDIHLAPGQEPPFGNDFFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFW7</accession>
    <name>A0A367LFW7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16 18">Delta(24(24(1)))-sterol reductase</fullName>
            <ecNumber evidence="16 18">1.3.1.71</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">C-24(28) sterol reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Sterol Delta(24(28))-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">L249_1035</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ergosterol + NADP(+) = ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16933"/>
            <dbReference type="ChEBI" id="CHEBI:18249"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.3.1.71"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:18503"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="15 18">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 18">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.71" evidence="16 18"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFW7"/>
    <dbReference type="STRING" id="1330021.A0A367LFW7"/>
    <dbReference type="OrthoDB" id="5326588at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000246">
        <property type="term" value="F:Delta24(24-1) sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000003">
        <property type="entry name" value="C-24(28) sterol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF31">
        <property type="entry name" value="DELTA(24(24(1)))-STEROL REDUCTASE ERG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01017">
        <property type="entry name" value="STEROL_REDUCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="9 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 18" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14 18" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="10 18" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="13 18" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="283"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="366"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="405"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="441"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="82"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00038892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00048918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU369120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RCI13308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="604" mass="68881" checksum="C9D2D703C26CF7C2" modified="2018-11-07" version="1">MSRYSLRQTPRKKELFDGMVATPVMRRSSRRHSSFPQDVSDLDNDSSSAAETSTRGARSVRSRRSAARLVEYADGADARVRTRAGTRKADANGAAAASASADTSNISGSDSDVKRVASSHDAARKSASPRVVDGWKPGQDPKVDLSTEFEFGGSLGTAAMIVLFPVLMWYMWIGATYYDGKLPTPTPDQTWLQFGAEMASLVYSGAFPHAAAWLWYWSYLVFQAACYCLLPGVWGRGKPLPHEGGKQLPYFCNAYASLYFTLAVLAVLHFSGIWPLYLALDHFGPLLSVAILSGFLVSLVAYVSAVYRGSQHRMTGRVVYDFFMGAELNPRLFGILDFKMFCEVRMPWYMLLILSLGAAARQYERYGYVSGEVLFLVLAHYLYANACAKGEELIITTWDMYYEKWGFMLIFWNLAGVPLSYCHCTIYLANHDPSEYRWNRWALAALFVSYLFWYWVWDSCNSQKNRFRAMESGQMVIRSTFPQVPWQTLRNPKTIESPRGTILVDGWYGLARKIHYTADAWFAISWGLVTGFKSPFPWFYPIFFCCMIAHRARRDIHRCRTKYGDAWLEYERQVPYLFIPITFKFFFDLEMASGTFYKIQLPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LG88</accession>
    <name>A0A367LG88_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5617</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LG88"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI13429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="79" mass="8719" checksum="94022C5B909A6418" modified="2018-11-07" version="1" fragment="single">TLIYRKFDCLDRPPFLGSLTYPTFLPSYGPYGPYGRSRSAVTYSLCDVRRPRAGCSRPGVTVSGAPAKLCLDLYYTIGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGC8</accession>
    <name>A0A367LGC8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MYND-type zinc finger protein samB</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Suppressor of anucleate metulae protein B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_5528</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in determination of the onset of polarized growth and morphogenesis. Plays a role in the regulation of branching in hyphae and spore formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MUB1/samB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGC8"/>
    <dbReference type="OrthoDB" id="5594178at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990304">
        <property type="term" value="C:MUB1-RAD6-UBR2 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.140.2220:FF:000003">
        <property type="entry name" value="MYND-type zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051664">
        <property type="entry name" value="MYND-type_zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47442">
        <property type="entry name" value="MYND-TYPE ZINC FINGER PROTEIN MUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47442:SF1">
        <property type="entry name" value="MYND-TYPE ZINC FINGER PROTEIN MUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="12">
        <location>
            <begin position="571"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="136"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="280"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="411"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="204"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="420"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI13494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="617" mass="68669" checksum="C26D4198886FAF64" modified="2018-11-07" version="1">MREVNFSIPNVNKASVGITTALYDRRALDCTSTLPLINSLNHLAYLTTSSARIRDILTVDGGIERLVCILKHGRSRDMMGMWKWNLAFQCVVNIGVRGTENVRTRVVEADMVPVIATILDNYIKVIDKCREKAEEANQKQIREHHHRRNRIHEHHATPKASSSSPNRAGRTELDQRSARRHGPSPIDVSSAYAGPSSATGLSNTSATPPRSSASTSERPTSTTSRQLLSSRGLTGRLGGATIPTHSVHSLASASLTMDVVDGWNRPERESDRLASVIPFGPTYMASQPNSPTTPLPPPQLQSPTVRPVINNTDRPRRRPSIRHQNSMAEHDDLHTDSIPSDESQDADMTGTAESAMGIQDISMEDGDNLLAGASLQLTNPDESEVHHDAGAFDITHRGASSDGIIRGGNTNPAPVPSMGVSPSRNTLVSPSRPTATNPTVPRYLLDRQIIPSSQTLTAMPREEDVLMSLQLLAYVSKYCGLRSYFQKSHLVPKLAISKDFELAEGDESELEDREPPIDEEYLLPNNFNLFPLVEKFTVRYHSTDMQYWAGVVMRNLCRKDDTRGGIRQCAFYQCGKWEEYTRQFAKCRRCRRTKYCSKECQKCAWAFHRHWCVTASQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LH59</accession>
    <name>A0A367LH59_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Microsomal glutathione S-transferase 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_8150</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LH59"/>
    <dbReference type="STRING" id="1330021.A0A367LH59"/>
    <dbReference type="OrthoDB" id="410651at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.550">
        <property type="entry name" value="Membrane associated eicosanoid/glutathione metabolism-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050997">
        <property type="entry name" value="MAPEG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023352">
        <property type="entry name" value="MAPEG-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001129">
        <property type="entry name" value="Membr-assoc_MAPEG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250:SF26">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10250">
        <property type="entry name" value="MICROSOMAL GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01124">
        <property type="entry name" value="MAPEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161084">
        <property type="entry name" value="MAPEG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI13758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="17346" checksum="6CDEF3C5C7779120" modified="2018-11-07" version="1">MNTLGLQLPDQYGFVLAAATSTFFVNSLHAFRTMKFRKASGVQYPEAYASTEQAAKNQNAYRFNCAQRAHHNFTENHTSFLGALLIAGLRYPVPAAALGAGWSICRVIYLIGYTSSAGPRGRLTIDARLCFRSGALGANLSDLLLKLVAAYTSAMFILGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LH85</accession>
    <name>A0A367LH85_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LH85"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="119" mass="13145" checksum="BD058F66A1F246AB" modified="2018-11-07" version="1" fragment="single">TLLHTHTQGTRPEGLEGSRNAGPAVAGPRPLYVIEAEAATATARLRCTAATAVRAVRAVRRKERRLLFSSSGFPSFFSLPLLPTAGPTAYRDDRVRVRIRIRIKIRNEIDSGIREKIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LH98</accession>
    <name>A0A367LH98_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LH98"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="62" mass="6779" checksum="66B5E36CDFD70A1E" modified="2018-11-07" version="1" fragment="single">EAATPYSGYGYTGRTGRTKEGTRDIPYNNYARAVTRIKSIAINIKAFCLKAYSNAKEASLAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHA7</accession>
    <name>A0A367LHA7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_7929</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHA7"/>
    <dbReference type="STRING" id="1330021.A0A367LHA7"/>
    <dbReference type="OrthoDB" id="25131at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00413">
        <property type="entry name" value="Glyco_hydrolase_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38121">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38121:SF5">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016942226" description="GH16 domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="31"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI13823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="376" mass="41170" checksum="8CE3C66CA6AB6334" modified="2018-11-07" version="1">MYKMKSLCFLLPFFISGLAAALCECGYAANVSYEGGGRPLLFTDLLESDFTKTRNISEDQDWIRQQFNVSAKAGRGRYGKSFSLDNILSHDSKTTVDNSQDSPGLQLRVDGVLNNDAVTAAEMDSARNDLHWGSYRAGLKLTAVNGTCAAFFWYLNDSQEIDMEFLSHEYDAGKHVYPVNLVIQSRKSMQAGYDASRSATYKRINLTFDPTAAFHEYRFDYMPGRVMFFADSVKLAEMEGDEMPTAPGHLILQHWSNGNPKWSGGPPTQDALLTVSYVKAYFNSSENKARSSWEERCRQTRGAAICNIPDVTAANASTGGHFFTEGGSRKMGGDVDSGCANRGGYGVSGLTAVVMATLAVLVNGTGRESQRVPPCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHV0</accession>
    <name>A0A367LHV0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI14013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHV0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="418" mass="45000" checksum="FE5467A3B597BE4B" modified="2018-11-07" version="1" fragment="single">FKYTTAENIVYFGGSARHSYTHIQGTRPEGLGGSRDAGPAVAGPRPPYVTEAVRHSGCGYAVQRLRPYGPYGPYEGRNPATAAAAAADPEGLFNYRLLRGGEDEGPAPADLAAFFFFLPTAGELTADSTLFFFDLCRYGYGYGKRPRCYGPSTASSFPLERSFRPDFFGCFFRPLVFRPFLPSLFFLRPALRPIATTGTGSGSGSGLGSGSGSGLGTRSIAEYGYEPRAAVTITGITAAYERTYGRTVPTPPIVVTFVLVFIRTVGYRDKLRRHEARRPKTKDTIDWLEKHAFFCRKVGPGPDESIEHSYGLFQALPKEIQGLGGSRDAGPAVAGPRPPYVTEAEAATPYSGYGRTGRTGRTRPEGLGGSRDAGPAVAGPRPPYVTEAERHNNVGGGYAVQRLRPYGPYGPYEGRNVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LI15</accession>
    <name>A0A367LI15_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_8296</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI14027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LI15"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="51" mass="6181" checksum="5AECF06C841FD7B2" modified="2018-11-07" version="1" fragment="single">RNREEEEESRNSLKEAIKEELEAGEVFVLRRYFSRYFKVPTCSTLTYLYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LI31</accession>
    <name>A0A367LI31_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial oxaloacetate transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_7934</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI14084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LI31"/>
    <dbReference type="STRING" id="1330021.A0A367LI31"/>
    <dbReference type="OrthoDB" id="6703404at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051508">
        <property type="entry name" value="Mito_Carrier_Antiporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45928">
        <property type="entry name" value="RE38146P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45928:SF1">
        <property type="entry name" value="RE38146P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="2"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="107"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="208"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI14084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="308" mass="33620" checksum="EE0968645FDE1181" modified="2018-11-07" version="1">MSTTLGAFVAGGIAACGAVTATHPFETVKIRMQLQGELQSKGHQPHHYRGPFHGVSVIVRHEGVRGLYRGIGCAYIYQILLNGCRLGFYDPLRKGLGSLLFHNQDAQNLAINMFCGASSGVIGAAAGSPFFLVKTRLQSYSPSLPVGTQHRYRNAWDGLSKIYRSEGVAGLYRGTGAAMIRTGFGSSVQLPTYFFAKRRLIRHAGMEEGPALHLASSTVSGFVVCCVMHPPDTIMSRLYNQNGNLYQGVFDCLGKTIRTEGFLAIYKGFLPHLARILPHTILTLSLAEQTNKLMRRFEGQVLPMLAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LI42</accession>
    <name>A0A367LI42_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acireductone dioxygenase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Acireductone dioxygenase (Fe(2+)-requiring)</fullName>
            <shortName evidence="11">ARD'</shortName>
            <shortName evidence="11">Fe-ARD</shortName>
            <ecNumber evidence="11">1.13.11.54</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Acireductone dioxygenase (Ni(2+)-requiring)</fullName>
            <shortName evidence="11">ARD</shortName>
            <shortName evidence="11">Ni-ARD</shortName>
            <ecNumber evidence="11">1.13.11.53</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ADI1</name>
        <name evidence="12" type="ORF">L249_8124</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 3-(methylsulfanyl)propanoate + CO + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14161"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:17245"/>
            <dbReference type="ChEBI" id="CHEBI:49016"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.53"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>1,2-dihydroxy-5-(methylsulfanyl)pent-1-en-3-one + O2 = 4-methylsulfanyl-2-oxobutanoate + formate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24504"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:16723"/>
            <dbReference type="ChEBI" id="CHEBI:49252"/>
            <dbReference type="EC" id="1.13.11.54"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
        <text evidence="11">Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 5/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the acireductone dioxygenase (ARD) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.54" evidence="11"/>
    <dbReference type="EC" id="1.13.11.53" evidence="11"/>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI14106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LI42"/>
    <dbReference type="STRING" id="1330021.A0A367LI42"/>
    <dbReference type="OrthoDB" id="1867259at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00878"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010308">
        <property type="term" value="F:acireductone dioxygenase (Ni2+-requiring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010309">
        <property type="term" value="F:acireductone dioxygenase [iron(II)-requiring] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02232">
        <property type="entry name" value="cupin_ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000079">
        <property type="entry name" value="1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03154">
        <property type="entry name" value="Salvage_MtnD_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004313">
        <property type="entry name" value="ARD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027496">
        <property type="entry name" value="ARD_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23418:SF0">
        <property type="entry name" value="ACIREDUCTONE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03079">
        <property type="entry name" value="ARD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8 11" id="KW-0408">Iron</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 11" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="3 11" id="KW-0533">Nickel</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <note>for iron-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <note>for nickel-dependent acireductone dioxygenase activity</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI14106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="171" mass="20187" checksum="7347244E36BEDF42" modified="2018-11-07" version="1">MKAYIYDNKEGDQRLPHDSGRIVSIEDLSHVGVRYFHCPSLSDVDKLAAERGYKNRDEITVSPQALGAIYEEKVKTFFEEHLHEDEEIRYIRAGRGYFDVRGPEDVWLRVMLEKDDLLILPAGIYHRFTTDDSNYVHAMRLFKDEPKWTPFNRCPQLDKNVVRRSYINTYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIM6</accession>
    <name>A0A367LIM6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_8122</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI14112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIM6"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="79" mass="9192" checksum="4252EC9813D544C7" modified="2018-11-07" version="1" fragment="single">GYSGHVIAVIAGQIDRIDRINQIDQIGQIATSLPPNRRSSNRDFEVSRENHQHQLFSPSQYKHFPCLQFFFNFLFQTIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJ22</accession>
    <name>A0A367LJ22_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ADP,ATP carrier protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L249_6182</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane.</text>
    </comment>
    <comment type="function">
        <text evidence="16">Catalyzes the exchange of ADP and ATP across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:35000"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 16">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Membrane</location>
            <topology evidence="16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJ22"/>
    <dbReference type="STRING" id="1330021.A0A367LJ22"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000001">
        <property type="entry name" value="ADP,ATP carrier protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF14">
        <property type="entry name" value="ADP_ATP TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0050">Antiport</keyword>
    <keyword evidence="11 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="13"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="118"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="218"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCI14424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="315" mass="34476" checksum="CBA44F3543ECB751" modified="2018-11-07" version="1">MSPPEQQKVLGMPPFMADFLMGGVSAAVSKTAAAPIERVKLLIQNQDEMIKSGRLERRFNGITDCFKRTWTDEGFLSLWRGNTANVIRYFPTQALNFAFRDKFKKMFGFRKDRDGYAMWMVGNLASGGAAGATSMLFVYSLDYARTRLANDAKNAKKGGERQFNGLIDVYRKTMASDGIAGLYRGFMPSVAGIIVYRGLYFGMYDSIKPVLLTGNLANSFLASFMLGWCVTTGAGIAAYPLDTIRRRMMMTSGEAVKYKNSFDAARQIIAKNGVKSLFNGAGANILRGVAGAGVLSIYDQLQLILFGKAFKGGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJ98</accession>
    <name>A0A367LJ98_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_6094</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJ98"/>
    <dbReference type="STRING" id="1330021.A0A367LJ98"/>
    <dbReference type="OrthoDB" id="6262491at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855:SF11">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855">
        <property type="entry name" value="WD40 REPEAT PROTEIN 12, 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="136"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="288"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="379"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="392"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI14491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="405" mass="44281" checksum="A489CAC266CDB360" modified="2018-11-07" version="1">MTAYFFQTDASQARREIKSAKAGNKNGNPIHARREIKSAKAGNKNGNPIHVKSKILAAIADPSCPLDSIFIAQSSGCVRRVRVDNAESPQTTYRGPKAPVTCLAIGGIENQTLFAGSWDKDVWSWDVASGRPGRKYNGHADFVKTIVCARLAGHELLISGGADRKIIVWDVETGRRLYDIQDAAKTMLAVQHVAVDPALSNQDTLVLVSASSDPHIRRWELSLDGYQQLFGSARSSGGTERPTIHEHDTSVYKLFFDTKVDEVDLWTASADGNVKCLARNQGFAADEVLVHGDYVRAVVVTPHWVVSAGRDDNVKVWDRRTGKLHCSLEGHFEEVTDLVLLRDGQGSPKLVCSVSIDGTIRTWPLSESELAEVVSRAGRVEPATGTEQQLTAEEEAELAELLDDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJY1</accession>
    <name>A0A367LJY1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_6680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJY1"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="90" mass="9822" checksum="104F1E8DE7FF0D93" modified="2018-11-07" version="1" fragment="single">MVDRTTSLDISQSVPFPSVPFFCFFPGESLVFQWAGMIPPRHPPSISSHRPSESTGGTWPASSPTNLFLLHVEKIGDDGIGRQTTLGYDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJY2</accession>
    <name>A0A367LJY2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="26">4-nitrophenylphosphatase</fullName>
            <ecNumber evidence="25">3.1.3.41</ecNumber>
            <ecNumber evidence="5">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-dependent DNA helicase II subunit 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">ATP-dependent DNA helicase II subunit Ku80</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">L249_6454</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29 30">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>4-nitrophenyl phosphate + H2O = 4-nitrophenol + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21664"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57917"/>
            <dbReference type="ChEBI" id="CHEBI:61146"/>
            <dbReference type="EC" id="3.1.3.41"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ku80 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="29">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.41" evidence="25"/>
    <dbReference type="EC" id="3.6.4.12" evidence="5"/>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJY2"/>
    <dbReference type="STRING" id="1330021.A0A367LJY2"/>
    <dbReference type="OrthoDB" id="30826at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00873">
        <property type="entry name" value="KU80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000073">
        <property type="entry name" value="ATP-dependent DNA helicase II subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000039">
        <property type="entry name" value="Phosphoglycolate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1600.10:FF:000002">
        <property type="entry name" value="X-ray repair cross-complementing protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.240">
        <property type="entry name" value="Ku, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006357">
        <property type="entry name" value="HAD-SF_hydro_IIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024193">
        <property type="entry name" value="Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036494">
        <property type="entry name" value="Ku_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005161">
        <property type="entry name" value="Ku_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014893">
        <property type="entry name" value="Ku_PK_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006349">
        <property type="entry name" value="PGP_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025423">
        <property type="entry name" value="TMEM205-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01460">
        <property type="entry name" value="HAD-SF-IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01452">
        <property type="entry name" value="PGP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF4">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13664">
        <property type="entry name" value="DUF4149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13344">
        <property type="entry name" value="Hydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13242">
        <property type="entry name" value="Hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03731">
        <property type="entry name" value="Ku_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08785">
        <property type="entry name" value="Ku_PK_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101420">
        <property type="entry name" value="C-terminal domain of Ku80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="18" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="19" id="KW-0234">DNA repair</keyword>
    <keyword evidence="16" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="12" id="KW-0347">Helicase</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="17 27" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0779">Telomere</keyword>
    <keyword evidence="8 27" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 27" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="725"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="766"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="27">
        <location>
            <begin position="810"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="28">
        <location>
            <begin position="6"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00024890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00031847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00050247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00066659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00069197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="RCI14710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1117" mass="122196" checksum="301F9651772DB93B" modified="2018-11-07" version="1">MADKEATVFILDLGASMARANAGRDESDLDWCMRYVWDKITDVVAANRKTLCVGIVGLRTDETNNKLQADDGYENISVLQDLGQMTTPSLRTLQESIRPSSSWSGDAISAIVVAVDMMETFTKKLKWIRKVVLITDGQGEMDADGIDDIAQKINDSAIQLTILGVDFDNPEYGFKEEEKSETKAASEAALRKLVDACDSAIFATMAEAIDELDLPRVKAIKPFKTYDGPLTLGDPETLPCAVNINVERFFATHLARPLAATTVVFKSDQATGTQSTHTLEGDASEGADFASVKQARAYKVNDPDAPGGKRDVEFEKLARGYEYGRTAVYISESEHNITKLESQKSFSILGFIPCNKYEPFLNMGETCATYARQGDAKSELALSSLVWALDELESYAVARIVVKDGKDPMLVLMAPHIEPGLECLYDVPLPFAEDVRSYQFPPLDRVLTVSGQTLTNHRLLPSDELNEAMNDYVDAMDLSTYGTEGGMGSAEYATIDETFNPSIHRINHAVRIRAVHPEKPLPQTPRVLLRYCAPPEDLIERVHSRIKALVEVAEVKKVPPKAKGRRARESVKPISGLDVDALLGDKKKGQVSRENAIPDFKQALVATTSTDEVEDVAKQMGAIVRGLVTDSFGDSRYAQAAECMGVMREELLRLEEPDVYNTFVRELKKALLSGALSGDRREFWYLVRSSRLGLIDKDQTEVSAVLPEEAEEVHTMAESIVFSVAPYHIISYGTLLGASVFHSFINGPVMYKSIDRPAFSAAQQNLFPIYFSLQTALPAVLALTFPGSTLAGVPNSVSGLLDVSSRWDSLVPIATMFVTGLVNLAVLLPATVKTMKERRGQCVLWSGDEVFQGVPETLEMLRSRGKRTVFVTNNSTKSRQEYAEKLLKLGIPSKVDDIFGSSYSAAVYISRILKLPEDKNKVFVIGEAGVEAELASEGVPFIGGSDVAFRRDVTSQDFQGIADGSLLDPRVAVVLCGLDFHVNYLKLAHALHYLQRGALFLATNLDSTFPTYNGLFIGAGSVLAPLANATGKTPLELGKPSQAMMDAIEGKFRLDRARTCMVGDRLDTDIKFGLQGKLGGTLHVQTGVNKKEDWQSGDAVAVPSFFADKLSDLLLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJZ8</accession>
    <name>A0A367LJZ8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJZ8"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="94" mass="10251" checksum="D8F118A5D63E7078" modified="2018-11-07" version="1" fragment="single">AYSGVGSIRSIGSTRTSLPPNHRSSKYVRVLQVGTLKYLEKIISISFSHLLNTNTSPASNSSLIASFRLLRDSSSSSLSRDYLPDSSTLYLLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LK35</accession>
    <name>A0A367LK35_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_7052</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LK35"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI14781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="424" mass="47085" checksum="AB28E55B334274DE" modified="2018-11-07" version="1" fragment="single">GPRPPYVTEAERHNNVGGGYGTATPYSGYGRTGRTGRTKEGTQGGFPGSVTMLRYSFALRSRLGLQRQQQQQRQQRQQAQKDYLITGCQEGGRTRGPRQQTSRPSSSSSSFLRQGSQRLNPRSFFSTSADTATATANALVAIVPLLLLLSLSNALFGPIFSAAFFVLWSSVLFFPPSSSYGRPYDLQRRQEQGQDQDQDQDQERDRQQNTGTSREQQSQQIQQEQRQQTNVPTAVPYLRPPQSLPSSSYSSSSSSLPESFVVLFVVFFFVFSFLRPYPPPMTFSRKGNSAVLTEDLPWPAAKTALLRYYGAFDQIRTVGYRDKLRRHEARRPKIKDTIDWLEKHAFFCRKIGSSYGPGPGSDRLLRRTRPEGLGGSRDAGPAAAGPRPPYVTEAVRHSGCGYGTATPYSGYGRTGRTGRTKEGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LK42</accession>
    <name>A0A367LK42_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6475</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LK42"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="162" mass="17766" checksum="3F4B65B820BB8D37" modified="2018-11-07" version="1" fragment="single">MKTKTSQAETDSADGDLLDIFSPDPSLQLTARLDGLAVRYGPSTSRGERGGGQADLFLASSTVRREFSLSPSLILSVAAFGSPSIRGRPAQQTPFFGADGRLERRRRWYAANERQKSRRRATEACFQSGQGRPETGKSHCYTDGASLRRDRQGLCDAPQLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKI0</accession>
    <name>A0A367LKI0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_7025</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKI0"/>
    <dbReference type="STRING" id="1330021.A0A367LKI0"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000313">
        <property type="entry name" value="MFS quinate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF8">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="512"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="33"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="88"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="565"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="91"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI14938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="595" mass="65050" checksum="519AEE26C1703734" modified="2018-11-07" version="1">MAGGAGVKKPVNIFRLRDLDEPAGAFNWRLWFAVSSFGLLGAARGIDEGLISGAFNSPGFQDGIGYRSFSDVERANVKANVSAMVQIGSVGDDDDDDDDDDDDDDDDDDDDDDDDDDDGDDDDGKGLIFLLDSAFWVCDRIGRIMATRFLCLLWVLGIAIFIGGGVRGSLAAIYAGRFIAGLGVGQTPVVGPVYISEVAPASIRGLCVTFFSGSVYIGIVLAYFTNYGCAVNLDEHGYNRWVVPTSLHIIMAGIIFILSFLQLESPRFLVKQKRPRDAAVVMAHLRQQPVDGKYVTAEIARIQEALHRELEATQGVGWLGQVKEMFFDPANLYRLYLTTMVQLLSQWSGAGSITLYAPDLFKILGVVGSEEGLLVTAVFGIVKLVAALVCALFLVDVIGRKRSLLLGIALQAISVIYVASFLTAIPRLGVDQAFVLPAADRAASRGAIAMIYLSGCGWALGWNSMQYLLTAELFPLRIRALATSWAMTLHFANQYGNSRAVPVMLLPVSKHGISPSGTFWCFAAVTLLGGFWVWFSVPETGGRSLESMDRLFELPWYQIGRRGNRHAEKRDEEKERIAEKESIVDRQGKTETIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LL81</accession>
    <name>A0A367LL81_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_6445</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LL81"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI15194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="125" mass="14604" checksum="56BB51DD5F4C3928" modified="2018-11-07" version="1">MISMLHIRLEWNKKNMAKIMHTQRFDDANSCANLAWIQDRRLYRQLWITPSTSLEIPSAYSSFCTHTFLNQSYRTAAQVYIQPLLVTTLSVQLRTSPSYHDLFHGSTLLQRDVFARLVELKTVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLG5</accession>
    <name>A0A367LLG5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">Superoxide dismutase [Cu-Zn]</fullName>
            <ecNumber evidence="7">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_6462</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="7">Binds 1 copper ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="7"/>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLG5"/>
    <dbReference type="STRING" id="1330021.A0A367LLG5"/>
    <dbReference type="OrthoDB" id="2015551at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00305">
        <property type="entry name" value="Cu-Zn_Superoxide_Dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018152">
        <property type="entry name" value="SOD_Cu/Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00068">
        <property type="entry name" value="CUZNDISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00332">
        <property type="entry name" value="SOD_CU_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="8">
        <location>
            <begin position="4"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI15240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="117" mass="12010" checksum="1825A0576EF7CB40" modified="2018-11-07" version="1">MGNKSERGFHIHTFGNLTGGCASTGPHYNPFNQTHGSPDDAVRHVGDLGNIKADDQGVAVGVLTDDQIKLMGPYSVIGRAVVVHDSTDDLGKGGHQLSMQTGNAGGRSACGVIGVAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LN14</accession>
    <name>A0A367LN14_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_2958</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LN14"/>
    <dbReference type="STRING" id="1330021.A0A367LN14"/>
    <dbReference type="OrthoDB" id="264917at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16514">
        <property type="entry name" value="RING-HC_LONFs_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.40">
        <property type="entry name" value="LON domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003111">
        <property type="entry name" value="Lon_prtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046336">
        <property type="entry name" value="Lon_prtase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327:SF42">
        <property type="entry name" value="LON PEPTIDASE N-TERMINAL DOMAIN AND RING FINGER PROTEIN C14F5.10C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23327">
        <property type="entry name" value="RING FINGER PROTEIN 127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02190">
        <property type="entry name" value="LON_substr_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00464">
        <property type="entry name" value="LON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51787">
        <property type="entry name" value="LON_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="242"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Lon N-terminal" evidence="7">
        <location>
            <begin position="329"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI15843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="598" mass="68106" checksum="4C9143A002C1CC05" modified="2018-11-07" version="1">MATSFMPQDDPDAAAAARSASAVDHGNPRPHPDFARHITRLSSEGRLCETVHDNGNPRPHPDFARHITRLLQCRLCAIPYKLVVTLPCGRSICRSCLPPSYVRDWITYPSAPDRHQVIQCPFPDCGRVHAVKDCSSDVTLNKLATMVHSVVARAWTEAASLGFIKESPVLEPMPEIPDDYEQKHLVVDTRFLATWFLATQSLLDYDDEFHFHVTHGQHTQAEHFDIGLLQTLQQTLRSEVDCQICFSLLYDPFTTPCGHTFCRHCLMRAYDRRECCPLCRRPVDIDRLLKPDACPSNDCITGLIRTFWQDEVDARKEAFVAEGMATRHLIHIPLLVCGLSFPGQPMYVQIFEPQYHRMLENVLNGNGKFGMVMPLDPERLGDGFHPIGILLQIKNTWYRQDGRSLVELEGLSRFRVLNWYTHEGYTVGVSERADDVGVEQEEAMEAAEVGYDASDSAAGGHLYQFYDTRDEEAAATAPFWTSWRQFGSDMPESAVDLDAMTTESLMRFALSFVDRTREKKVPWLTEAKLMTYGECPDDPVLLPWWFGSTIPISNPQKVRLISAFTVRDRLKICGSWILEMRRRTRYKEQRAEPMGIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LN50</accession>
    <name>A0A367LN50_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Actin-like protein ARP6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Actin-like protein arp6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_2549</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the SWR1 chromatin remodeling complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family. ARP6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LN50"/>
    <dbReference type="STRING" id="1330021.A0A367LN50"/>
    <dbReference type="OrthoDB" id="6220758at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10210">
        <property type="entry name" value="ASKHA_NBD_Arp6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000014">
        <property type="entry name" value="Putative actin-related protein 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00063309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI15864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="441" mass="48658" checksum="C7FDACA3B080A057" modified="2018-11-07" version="1">MAGGRKPSHSAAATRPQNTLVVDNGAHTLKAGLVRGGSVDDPAVIPNCVGRDRARGLYVGSDLEKCRDFGEMQFRRPVEKGFIVNWDVQREIWQHELLDLCDASETRLVLAEPPNGLPALQANCDQIVFEEFGFASYYRGLGPVFNAYHDVQSFFHTPRDVPTVPAAPAEILLVVDSGYSHTTVTPVLRGHSINTAVRRLDVGGKTLTNYLARLVSLRHLDMRNDTYIVNEIKEAACYVSQDFAVDLEKCWKGTRGDRRPEYHSSGGIVKDYVLPDFHTRFKGVLREHDPIKHPKAGRMATSDEDVVTLRNERFSVPELLFNPSDVGIRQVGIPQLIMQSLHGLPVGLWPGLLANVVVVGGNTLFPGFVDRLQSEVVRRAPDSCVVRVARPPDPITCTWRGAANMANHVDMEAVAVTKQEYEELGAALVARKFASVTVLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LP42</accession>
    <name>A0A367LP42_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1876</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LP42"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="83" mass="9056" checksum="D4C19956363283C5" modified="2018-11-07" version="1">MRDKQPRGRLSLLPPQVPANKSQRHLCSTGLNAVIFPPCSKKTSNPQPLRQLGVAQAAPLSHGPPRPSFPVRQAFMEYRAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LP99</accession>
    <name>A0A367LP99_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_1903</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LP99"/>
    <dbReference type="STRING" id="1330021.A0A367LP99"/>
    <dbReference type="OrthoDB" id="4142200at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF7">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="428"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="457"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="9"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI16240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="550" mass="60442" checksum="B005A71E8BC3A035" modified="2018-11-07" version="1">MPIGNIYVIAAVSVVGGGLFGFDISSLSAQLGEQAYRCYFNQGPAGPPFNDDEKCTGPHDLVQGGITAAMAAGSWLGALCSGPLSDRAGRKYSIMVGCVVWIIGSAIICASQNIPMLIVGRLINGFSVGIESAQVPVYIAEISPPSKRGRFIGMQQWAITWGILIMYYISFGCSYIGEQNSRNYSQAAWRIPWGLQMIPAVFLLFMMFFLPESPRWLARKGRWDDCRSVLVLVHGKGDAHDPFVSYEMDDIKQMCEFEQRHSNVTYLDLFKPGMIHRTLIGLFTQIWSQLTGMNVMMYYITFVFGMAGYTDNAGLLASSISYIINVVMTIPALLFVDRWGRRPTLLVGSVLMATWMFANAGILAAHGEVVEGGIDHVSSQSMRVTGAPATGLIACTYLFVASFAPTWGPVSWIYPPELFPLRLRGKGVALATSGNWAFNTALGFFVPVALANIKWRTYLLFAIFNVAAFFHVLFLFPETAGKTLEETEAMFEDPNGIKYIGTPAWKTNVSTKLVSRAEHGDVEAVEAKRHADYNGSELHEDDKVVAHKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPB7</accession>
    <name>A0A367LPB7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pheromone-regulated membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_2805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPB7"/>
    <dbReference type="STRING" id="1330021.A0A367LPB7"/>
    <dbReference type="OrthoDB" id="2128042at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031606">
        <property type="entry name" value="Kch1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36424:SF1">
        <property type="entry name" value="LOW AFFINITY K(+) TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36424">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16944">
        <property type="entry name" value="KCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="452"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI16227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="511" mass="56159" checksum="DEFEB7B2274BA24C" modified="2018-11-07" version="1">MGCISHRKKQTHEFTDLQWSYISLKDFKAKGCGPGFFYGWLWFSLILSIAVYAVDSFTAVNLLAFNTWSSKIEPAIPLNVSKWIFSGCIIASFVNIGFEGIRAFRVMRRGNVAECYMDSLAARWESIRPGSGQGWRRFLVFTEVTKSKKGAEYIALFTYFSFQTWIRVILCSGPRQVVNAFTLKSVYEAKLNPTSTSVEGSITGFFDKIRALATEDYQQAAILSGMLFTLIVWVFSALFLLAAVLFYVFFLFHWIPRADGGLTGYCVRKVNQRLTRIVTTKVNRALAKGQAKRERAQDVWAAKSGEKPHLERSATIPTIPDVGVGGDGLPEMPVLSRSGTNLSSSTLDSYPGPLLYQQRMVQSRPGTPNSAYSARAPLVGAAAQMGHSASPVMPPRSYPAGDFGLERTGSQRSLGSQRSFGTQQSFGPRPAVGRPSPLTRPHEAATYSDGRSSPAPSMASNPAGYPVAQPFRPTPAGQPYQPMRGPAPQYPAQLNMTPQMGQGPQGPFDYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPG0</accession>
    <name>A0A367LPG0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPG0"/>
    <dbReference type="OrthoDB" id="4911120at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="345" mass="39960" checksum="3549C67A87ED027E" modified="2018-11-07" version="1">MAHGFLTLRIREHGPTAIAKKERRHLSGGIFTFLSLLRLLMFLILLVRFAMGLVSNCLFIMLFLQWLVVASHPGIECGRFQQHAFQTVLDSIDVSDDARFKAQYINPIYLHTLFSVLPVELLIAINTNWHLNTYRLAELLSEEQQYSPDTRTLRESIDFYREASINEIKVCWLSNLTIQHQYHKNVLGAVNNLLISYESAEWDMPRRPRYLPPGELRQDRPICLSADDVQARWFEKHLPALRRDKFQEDDTSPYFDLMKMKIETYTWAGTFGRIVQEAICKSQSGRALEHVVPGVPIPAGTYGSFFDKMSRFFRSRSGVCFTLGKMKSGSIPMRFYWIDAGRNRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPG2</accession>
    <name>A0A367LPG2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPG2"/>
    <dbReference type="STRING" id="1330021.A0A367LPG2"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="13"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="235" mass="26413" checksum="8094BB72B9F9BE5D" modified="2018-11-07" version="1">MPSPLASTTDDQHAYMLRYFPLRWRAEGARFLLLAKGSTFKEETPSWPAERSQQPLSQLPVLVERSAADGSEFVLSDSVAIERYLAARAGLLVQSGLRDSAREMQLRAQMEDIHTVLVQYKYGHEAGREMAMDKYRRLADSFVGYHEELLRRNGSSGHYFGEAITYADICLYLLLVLIRSPPDGFPPACEEPFSSGRAPAINRVYHAVREDALARPYVAWLEKDDPAAAARLASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPG4</accession>
    <name>A0A367LPG4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_2153</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPG4"/>
    <dbReference type="STRING" id="1330021.A0A367LPG4"/>
    <dbReference type="OrthoDB" id="5431149at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="293"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI16335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="448" mass="48194" checksum="9FB3696333F57608" modified="2018-11-07" version="1">MKRAYYLILGTLALLATSSVLCLQLIVIVNCRAVPLLPANATAASLQFLVLVLVWLFAVTTVFRDGRPSSIVYPNLKFALSLLACALAAAVSAAALVYLSSGSDAPLGQYRMQMLVATSIALAFATILQLTCIVRHFITSREPAVGRGTTPETPAVTPRRRLRRIKSIPYSRTKSCGDETMQEMASTTQPPSPIAMAPPTPCIFKHPFAPTVRPSSSKQKLMSTKKQQQQQQQQRRPSSADSGGQRSSVEASSFDSWDTSSVDMHNRQVVMDMSTSPSTQAHGLETIPDSPPRSRGSGARSPTDMGGLPRSLRTSRSLSHSRLKHREEGRTTPASSVHELHIHPLFRSDSQDPPPLASPGTSVLASPIAGKVITRRESSKSLGAMRNGSVVAAPQSPLAQQTCFESSDSLPREDRSASGGEDAASGSERKMTPPVPSWLLVREPHPNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPR0</accession>
    <name>A0A367LPR0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">4-hydroxyphenylpyruvate dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L249_2294</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="12">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 3/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the 4HPPD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPR0"/>
    <dbReference type="STRING" id="1330021.A0A367LPR0"/>
    <dbReference type="OrthoDB" id="414569at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00362"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003868">
        <property type="term" value="F:4-hydroxyphenylpyruvate dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07250">
        <property type="entry name" value="HPPD_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08342">
        <property type="entry name" value="HPPD_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.10:FF:000001">
        <property type="entry name" value="4-hydroxyphenylpyruvate dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.10:FF:000020">
        <property type="entry name" value="4-hydroxyphenylpyruvate dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005956">
        <property type="entry name" value="4OHPhenylPyrv_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041735">
        <property type="entry name" value="4OHPhenylPyrv_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041736">
        <property type="entry name" value="4OHPhenylPyrv_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01263">
        <property type="entry name" value="4HPPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959">
        <property type="entry name" value="4-HYDROXYPHENYLPYRUVATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11959:SF1">
        <property type="entry name" value="4-HYDROXYPHENYLPYRUVATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009283">
        <property type="entry name" value="HPP_dOase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="VOC" evidence="14">
        <location>
            <begin position="31"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="14">
        <location>
            <begin position="209"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR009283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR009283-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCI16434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="412" mass="46005" checksum="7D55A5E942CC1C2D" modified="2018-11-07" version="1">MAPSAVSPLQRAADANRQEHNGSDAYGNFTGYDHVTWWVGNAKQAAAYYTSLFGFHAIAYRGLETGSRYFASHVVANNGVRFVFTSPLRSAEHLPTDEPISDEDRELLGQMYHHLEKHGDAVKDVAFEVDNVEGVYQRAVKAGAVAVRAPKEQRDDEHGNVVTAVINTYGDTTHTLINRGSYSGPFLPGFRAARPSKASVTLPDVGLARIDHCVGNQDWNEMVSACDFYEQCLSFHRFWSVDDSQICTDFSALNSIVMASPNNLVKMPINEPAPGKKKSQIEEYVVFNSGAGVQHIALLTADIISAVSALRARGVDFIDVPQTYYDTLRQRLKSERRGWELREDLDTIQRLNILIDYDEGGYLLQLFTKPLMDRPTVFIEIIQRNNFEGFGAGNFKSLFEAIEREQAERGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPS3</accession>
    <name>A0A367LPS3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor CWC2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Pre-mRNA-splicing factor cwc2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">L249_1983</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the first step of pre-mRNA splicing. Required for cell growth and cell cycle control. Plays a role in the levels of the U1, U4, U5 and U6 snRNAs and the maintenance of the U4/U6 snRNA complex. May provide the link between the 'nineteen complex' NTC spliceosome protein complex and the spliceosome through the U6 snRNA. Associates predominantly with U6 snRNAs in assembled active spliceosomes. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM CWC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPS3"/>
    <dbReference type="STRING" id="1330021.A0A367LPS3"/>
    <dbReference type="OrthoDB" id="10251848at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12360">
        <property type="entry name" value="RRM_cwf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000249">
        <property type="entry name" value="Pre-mRNA-splicing factor CWC2, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034181">
        <property type="entry name" value="Cwc2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032297">
        <property type="entry name" value="Torus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16131">
        <property type="entry name" value="Torus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="8 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="19">
        <location>
            <begin position="181"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="18">
        <location>
            <begin position="243"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="16">
        <location>
            <begin position="181"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="106"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="437"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="404"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="454"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00072313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RCI16410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="463" mass="51247" checksum="1D9726348C18F16E" modified="2018-11-07" version="1">MPVPFRSLEAGSFAWQNSTYWGVDRHLHRLPHLTRAWPGRLALIILHRPPSSLVRLALRAELTQALKHVFCGSMADSERQTAETDDVGSRDDMALAKAEVAVAAPAEKKKTKMVRRKKRPARAQIDAGSISSEPPPQTGTIFNIWYNKWSGGDRESYQQTHARGRCNIAQDSGYTKADNVPGSYFCLRFARGLCPMGRDCEYLHRLPAPLDLFSPNVDCFGRDKFAGYRDDMGGVGSFMRQNRTVYVGRIHVTEDIEEIVARHFAEWGQIERIRVLNQRGVGFITYTNEANAEFAKEAMAHQSLDHDEILNVRWATADPNPMAQKREARRIEEQAADAIRKALPAEFVAEIEGKDPEANKRRRLESSYGLEGYEAPDEVHFARGPNAVNPLGRQGFEVPAQQLALPSSEPSTAGPTQGGGIFSESTLAALSGARVKVASKPKTATGPLVAYGSDSDDDDNDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPZ3</accession>
    <name>A0A367LPZ3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPZ3"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="208" mass="22711" checksum="FF2DF347D0ADF28F" modified="2018-11-07" version="1">MTASTASRVLSLLSSLASTHLPSSRPVPPDRISDCFLSEASTTSSHRFRRLSFSFFSIVGFIARYSAKALASLTVRSLRPPRFRLDPGTPRRRERKSSSDAERNVDKGVSERSGSCLLDRVVIISLISPSGNFSSRVWRSCVIVVVGGTGKTTVDGRPRPGKVETRTLRCFGAILIGMSASRVCSIERAEVTRSGRVKFGWALGRLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQM7</accession>
    <name>A0A367LQM7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_2550</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="2"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQM7"/>
    <dbReference type="STRING" id="1330021.A0A367LQM7"/>
    <dbReference type="OrthoDB" id="273917at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043634">
        <property type="term" value="P:polyadenylation-dependent ncRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045862">
        <property type="entry name" value="Trf4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092:SF15">
        <property type="entry name" value="INACTIVE NON-CANONICAL POLY(A) RNA POLYMERASE PROTEIN TRF4-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092">
        <property type="entry name" value="POLY(A) RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="7">
        <location>
            <begin position="384"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="6">
        <location>
            <begin position="584"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="180"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="325"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI16711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="737" mass="83352" checksum="A13362BCE3E080D3" modified="2018-11-07" version="1">MSRNDHRGRRDRDHDRDRDRDRDRDRDRDRERDRGDRGRNRDRDRDRAPDQYRDDRNRDRAYDRDYDRDYDRQLRSSDHWRPGDDSRNDASSYRSSNAHASRPPQSSFDFRVPKPAGIGPPPPPGSDGRPDPTRRRPGRYPPRPRRQPPNPSERALFSGTAFTAPGLRISDASVANKFRDLQELSDDDEVDMEMSSPSSEDGKPPAKRPRTAAAQSDTATAEVVPKWSNPDPYTALPCGTPDETVTRPKRDVIKLIRKARVEEPKPNSDAPSAAEDFISCSSDGDTDTKKVENAPVSFQLPPRPPAPAPRRSQTINLDDGSGDLGSRKRTVDDEIKPPSYGQPKKAPSRPYKGLLLPEWQPVSGESPCPWPTVEPLEGGDDAAEVMEFYDFVRPREFEHTIRTRLVQNLSEALRRHPAFREANVKPFGSFMSGLYLPTADMDLVVCSDTYLRGGPPIYLGKKKWLYIFQRFVVESGIAQEGSITVIAHARVPLVKYVDRLTGLKVDVSFENLGGVEAIKTFSAWKRDYPEMPVLVTVIKHFLLMRGLNEPVSGGIGGFSVICLVVSMLQLMPQSQSKDFQGDHHLGDLLLHFFELYGRQFDYRTMAISLTRPLGYIRKVRPAAVSVSLAHIFLDSQRQSDVARVTYKNPDRLSIIDPNNAANDISGGSSCTSIILSRFRDAYIDLRKCVTQQEADKEGRMLAVILEGNYSSFRKQRDYLKHVHEKMMGPCDDQKHLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQQ3</accession>
    <name>A0A367LQQ3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclin-D1-binding protein 1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_2546</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQQ3"/>
    <dbReference type="STRING" id="1330021.A0A367LQQ3"/>
    <dbReference type="OrthoDB" id="4088536at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026907">
        <property type="entry name" value="GCIP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049317">
        <property type="entry name" value="GCIP-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15492">
        <property type="entry name" value="CYCLIN D1-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15492:SF1">
        <property type="entry name" value="CYCLIN-D1-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13324">
        <property type="entry name" value="GCIP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-D1-binding protein 1-like N-terminal" evidence="2">
        <location>
            <begin position="64"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI16785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="378" mass="40572" checksum="C5C217EA65CF7DF6" modified="2018-11-07" version="1">MAPSPPSTNTNPLDNLLASASSLLSQLQSSLNQVVEESKDAEAPPTPSPTPSSSSDNSLSQTRDATKLIRLHGTKISPLVTHGATNPSTPPTKALSTVVIDLVGGPVPTLVSAAQSCRCGGLVLRRELALLAGRVLAALDGLLRSVAIAVVDQEHPSVRATAVLWSACDALVDLSSSAPAGFFVAKARQSEDLLNDVALELREWDEQEPDEEDDDEDDDDVQDTDSLSAQSLADSFLSPKPIPQNDLSNIRPRLTTTLRLLRLVALLLGIAHKRRLPDIVPDSRHSPRLDALARQLDRLPEHFEDLAASLYAMQPTDVDDNLRLCMRDAETVAGLLADGWDGLPDRFTGIVDRFRQELKHLEGDTSSTKMSPSSPASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQS5</accession>
    <name>A0A367LQS5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQS5"/>
    <dbReference type="STRING" id="1330021.A0A367LQS5"/>
    <dbReference type="OrthoDB" id="1911848at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1020">
        <property type="entry name" value="Prion-inhibition and propagation, HeLo domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056002">
        <property type="entry name" value="DUF7580"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029498">
        <property type="entry name" value="HeLo_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038305">
        <property type="entry name" value="HeLo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542">
        <property type="entry name" value="HELO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542:SF1">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24476">
        <property type="entry name" value="DUF7580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14479">
        <property type="entry name" value="HeLo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="310"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="629" mass="70823" checksum="9DEAFC03E8D324A8" modified="2018-11-07" version="1">MDPISVGGLAIGVASLGLQVYTGCIQGTYLNLRLRMEQQRLFAWSETSGLLDLDADNQDRILNSNLFSLHRQTILDLLVQVRCLFDDFTAHQRRHQNLSVERGDDDLLTAPERDARQANFPMSDRKRDFIRKAMERLRHKSQGGWLRLRWASFDKEAFERLLAKFTALNDEMTDLLDHSLQLEIRHTVQHTNRSVLLLHRKIADLGHLVLALKSQLDASGPTAAASPASTVRREAAVNALLQLTELAKFKAFNETIDPKAGAPTHIDVATAQSLQLASPDLPRHLRLDRHRIELDPAVDGQETPRCEAVLTTTTLDGGGETRKRVWIEWKNYDDAGIHPDSLSKEDIVDRVRKLACLLHRSPKPEAFRTPHCLGFFDKAEPDEVEADVDVLDRRLGLVFERPSGDLPPVSLHELLRDVGSRKPRVTERVRLAHALANCLLYLHAVNWLHKGLRSHNVIFFRSHSGDVDLAQPYLSGFDFSRPGGSDEMTDAPADDAEHDLYRHPLTQSNRRGERERSKKSFDVYSLGVILVELAHWRTVDEVLAVDMRRARGNPEMARRVRGRLLDEDSIAAIGAETGWRFEEATRACLTGGAELGLRPGDDETSDEVAEKLSAKYYEGVVKRLGDIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LR66</accession>
    <name>A0A367LR66_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Chromosome segregation in meiosis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_1754</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Plays an important role in the control of DNA replication and the maintenance of replication fork stability.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the CSM3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LR66"/>
    <dbReference type="STRING" id="1330021.A0A367LR66"/>
    <dbReference type="OrthoDB" id="437078at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031298">
        <property type="term" value="C:replication fork protection complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012923">
        <property type="entry name" value="Csm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040038">
        <property type="entry name" value="TIPIN/Csm3/Swi3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13220">
        <property type="entry name" value="TIMELESS INTERACTING-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13220:SF11">
        <property type="entry name" value="TIMELESS-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07962">
        <property type="entry name" value="Swi3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0236">DNA replication inhibitor</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromosome segregation in meiosis protein 3" evidence="9">
        <location>
            <begin position="62"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="142"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="241"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI16944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="266" mass="29209" checksum="7EB7184656F8BAD8" modified="2018-11-07" version="1">MSTAVAPPPPLGDLDDYDVNDSDDPFRSPSPSPATKRKAAAGGLGLDEEVSVQKRTRVPNIKLDEGRLLGPEGIPRLKERVGKLRIKGKGHEFADGERLLALYQFWLDDLFPKAKFLDALVMVERAGHRKALLQARNRWIDEGKPKDRQDEDDVDNGVNHDRESHESQPPTQENTSPATPRPKTPERNDVPDDDDLYDATPRAPTRSANDLDALMQETLNAEPDEDDLDALIAEAGVSDRIGAHDGVGPRDESGHFSDDEAAMAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRB5</accession>
    <name>A0A367LRB5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="3">1.11.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Nuclear thiol peroxidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Thioredoxin peroxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L249_1968</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the peroxiredoxin family. BCP/PrxQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRB5"/>
    <dbReference type="STRING" id="1330021.A0A367LRB5"/>
    <dbReference type="OrthoDB" id="338622at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03017">
        <property type="entry name" value="PRX_BCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000157">
        <property type="entry name" value="DOT5p Nuclear thiol peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050924">
        <property type="entry name" value="Peroxiredoxin_BCP/PrxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801:SF23">
        <property type="entry name" value="PEROXIREDOXIN DOT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42801">
        <property type="entry name" value="THIOREDOXIN-DEPENDENT PEROXIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="15">
        <location>
            <begin position="91"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCI16890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="241" mass="26549" checksum="FAC4375F08AC75F8" modified="2018-11-07" version="1">MPVELRKRKAPQPPPAPAPTTKKQPTTKKKKTTASSKSAAPLSKEAESESDPAPQKEEEKEKDEEKGKEEEEEEREKETKKTQKKTKVAVGDVLDLDDNFGGEIEDQDGQKTTLKQLIQDCKTGVVIFTYPKASTPGCTVQACLFRDAYDPVKAAGLSIYGLSNDKPKANTTFKEKQKLQYPLLCDPHATLIDALGFKKHPKGTQRGVFVVDANRKVLVCQQGAPAATVDRVKQLVREMNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LS19</accession>
    <name>A0A367LS19_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_2163</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LS19"/>
    <dbReference type="STRING" id="1330021.A0A367LS19"/>
    <dbReference type="OrthoDB" id="1937934at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22455">
        <property type="entry name" value="KH-I_Rnc1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22456">
        <property type="entry name" value="KH-I_Rnc1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22457">
        <property type="entry name" value="KH-I_Rnc1_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049786">
        <property type="entry name" value="Rnc1_KH-I_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="45"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="131"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="285"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="247"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="265"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI17187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="369" mass="39419" checksum="D3291CBA526B7C95" modified="2018-11-07" version="1">MSVPQDILSANGSDMAESMDQLKMHERLGPDGEPGPKTDEEYAQAQLTLRAIVSSKEAGVIIGKGGKNVADLRDETGVKAGVSKVVQGVHDRVLTITGECDAISRAYAIVARALLEGAPAMGMGGLVQSNGTHPIKLLISHNQMGTIIGRQGLKIKHIQDVSGVRMVAQKEMLPQSTERIVEVQGTPEGIQRAVWEICKCLVDDWQRGTGTVLYNPVVRNQPGGTGGMTTGGGYNSGRADYAPPRVMRTGNGADFSNGGARPFNRRSDSDAATRGPPTHDENGEEIQTQNISIPADMVGCIIGRAGSKISEIRKTSGARISIAKAPHDETGERMFTIMGTAKANESALFLLYENLEAEKMRRSQVQDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LSH7</accession>
    <name>A0A367LSH7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LSH7"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI17406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="549" mass="57093" checksum="9502C0A7A7624631" modified="2018-11-07" version="1">MLKQKCRSLEPFAVCLPTTSNYKSREVVKQQGISLGISNTLKAIFGFWEGVIRKRQPRPSILAAIQPQQPREVRESFSPPHCIDFASSTASKISRVFGIVYQPNTRKGATRHAYTHRLAALIQASETKPPRQDSRTFQQYGPVWFYAQNMEELSTQRTCLKASSELKSSSRRGSRDVRPGGMEGKKLESPVVTGTSYWNRCQSIAIWTDESGMLFTMSARERRSSSASATLSSLLIHRSLTTTTKETKDTAPILTMKQSLIYTLFVATATAAPSRPVAPRGIAQEGLAQGGFGGAIGGNGGVGGTSGGRPGGGQGGGGGLGGAVGGNGGVTGFKRGVSGPWDDFGRIGGKIGARGVAEETSTEGGIGRVGGNVGPRGVADDASTERRIIGPFGGRVGARGIAEEASTEGGIGRVGGNVGPRGIADDASTERRIIGPFGGRVGARGIAEEASTDGGIGRVGDRVRPWGIGRVGGNVGPRGIAEEASTQGGFGGGLGGGAGGNYGIGGVKRGMADDGDGEENKEETADWDENGSPGNDVFRRQDNEADEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LSM6</accession>
    <name>A0A367LSM6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_3308</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFA1 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LSM6"/>
    <dbReference type="STRING" id="1330021.A0A367LSM6"/>
    <dbReference type="OrthoDB" id="1920692at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017384">
        <property type="entry name" value="NADH_Ub_cplx-1_asu_su-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17098:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17098">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE MWFE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15879">
        <property type="entry name" value="MWFE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI17421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="107" mass="12163" checksum="C6BA44DF31F70267" modified="2018-11-07" version="1">MPVPFETLLPYAIMVAMFGVTGTGLAFVRTKQNEGKRPRYSLDAWDRLYPVMDRDRRLTGTMRGQTSEAEAPPGFEFTNGWKARHFAGLLTHLQSTDICLQTEKRIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KYV7</accession>
    <name>A0A367KYV7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000044">
        <property type="protein sequence ID" value="RCI07356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KYV7"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI07356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="155" mass="17490" checksum="BE7C00ED002EE977" modified="2018-11-07" version="1">MICVTSFCILTLWTLSFLALVSFDVYYIIIKDDDEEVMHTLSYPCNSTLPHRHPMDRGERERAWLPPGEKRKREEEGSRAGGGRASELRTVCDDAPDQARSRLPGVQQIIVTVGSQSGRLRVSVVMPGQHLLRADMVHRTTALCRYEATDDGIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KYY9</accession>
    <name>A0A367KYY9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_1374</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000031">
        <property type="protein sequence ID" value="RCI07391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KYY9"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI07391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="58" mass="6505" checksum="CCBBD468E74FB9AD" modified="2018-11-07" version="1" fragment="single">FNPEHVEPRCTHHITSQAGRQAANALLEKKTYSLSEAIIISGDVNDEHMPDRITFFPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZ50</accession>
    <name>A0A367KZ50_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_4525</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000028">
        <property type="protein sequence ID" value="RCI07451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZ50"/>
    <dbReference type="OrthoDB" id="1735038at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF23">
        <property type="entry name" value="SERINE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016801288" evidence="7">
        <location>
            <begin position="20"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="18"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI07451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="519" mass="57367" checksum="064DC858EB80A399" modified="2018-11-07" version="1">MHLFSIVSAQLLLVSLTTATAPPPPPPPPPPPPPLPLPINGSHPHNNSTLQYFDQFIDHSNHSLGTFRQRFWYNTDHWGGPGSPILFKGPDEAPVEAASTSSSPRSLNGLLAKTNRAAMITLEHRYFGESLPFGKNFSTPNMRYQTLDNAMQDIIHFANSVHLPFDESGSSKPGKSPWIISGCSYSGALAAWINVLSPGTFWAYHCGSAVVEAISDLSGYFGQVEKAMPRNCSADIKRVVSHFDRVLADGSDEEKRALKKMYNVTGSDGDLGSTVTNAVSTWQDVQFSKTSDGYFFGMCDYVENQWPGSNSTVPDAEGVGQERAVEGLGKWVREIMPTIPHLDEDAQTSWLWFLCNEPISKLTKGEKNRFEWWQMAGPDDGGIVPKAVTRDYFIQQCRKQFPTRDEVTFGIDDGRTVEQVNARTGGWDSRVKTTRLLWVNGELDPWRPATVSSEKRPGGPLRSTKEAPVWVIPRAAHCSEMNVGNGEADDGAREVIDGVVKQMKEWVDEFYTTGKEVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZ76</accession>
    <name>A0A367KZ76_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial import inner membrane translocase subunit TIM50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_4518</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIM50 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000028">
        <property type="protein sequence ID" value="RCI07483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZ76"/>
    <dbReference type="STRING" id="1330021.A0A367KZ76"/>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FCP1 homology" evidence="3">
        <location>
            <begin position="135"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI07483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="330" mass="36915" checksum="C656A69220262962" modified="2018-11-07" version="1">MIYHIDQVTSQTEKMQLSDSPAPAAAKRLENESSQTPPSLARIPGLSLLHAEMKQETPQSDTPSSSVDEMKTSEESASNQTNGQPKASSETASTVNVLSSIRKTERSAPSRLSGGVPEPTCDYIAQSLMPAVTLPSPRRILVILDLNGTVLYRPAHFRPSSFVQRPYAHRFLSYCLDTFCLAIWSSARPENVERMVGQLLTPEQRSRCVVAWGRDRLGLCARDYAARVQCYKRLSTAWEDPVVQASHPYAAHGFKWDQTNTVLVDDSREKGRSEPYNILAVPEFSGPENEDSIVLPQVHDYLNTLCYQEDISCYMRRNPFQLSSDYILTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZA1</accession>
    <name>A0A367KZA1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_4539</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000028">
        <property type="protein sequence ID" value="RCI07498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZA1"/>
    <dbReference type="STRING" id="1330021.A0A367KZA1"/>
    <dbReference type="OrthoDB" id="6921389at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046165">
        <property type="term" value="P:alcohol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00685">
        <property type="entry name" value="Trans_IPPS_HT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF44">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI07498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="322" mass="36361" checksum="FB9C7F92019E1145" modified="2018-11-07" version="1">MAIVQQQQSEESTKKPSTRSLLDAYLSSQRRWNTDKEKVIRAPFDYTASHPGKDFRSQLIAAFDAWLQVPPLSLAVITKVIGMLHESSLLIDDVQDSSALRRGFPVANRIFGVAQTINSANYVCYLAMQELQKLKNPQAISIFAEEIINLYRGQGMELYWRDSLICPTEEDYLEMVGNKTGGLFRLGIKLMQAESASATDCVPLVDLIGLIFQIRDDFLNLSAEYTKNKGEFEDLSEGKFSFPIIHSIRSDPSNLQLINILKQRTSDTQVKRYAVSYMESTGSFSYTRAVLDTLIGHARKMALDMDDKQGSILKFLDKMTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZL0</accession>
    <name>A0A367KZL0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,3-beta-glucan synthase</fullName>
            <ecNumber evidence="3">2.4.1.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,3-beta-D-glucan-UDP glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_1659</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;3)-beta-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21476"/>
            <dbReference type="Rhea" id="RHEA-COMP:11146"/>
            <dbReference type="Rhea" id="RHEA-COMP:14303"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37671"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.34"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.34" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000026">
        <property type="protein sequence ID" value="RCI07608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367KZL0"/>
    <dbReference type="OrthoDB" id="1880850at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000148">
        <property type="term" value="C:1,3-beta-D-glucan synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003843">
        <property type="term" value="F:1,3-beta-D-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006075">
        <property type="term" value="P:(1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051278">
        <property type="term" value="P:fungal-type cell wall polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026899">
        <property type="entry name" value="FKS1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056261">
        <property type="entry name" value="FKS1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003440">
        <property type="entry name" value="Glyco_trans_48_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741:SF48">
        <property type="entry name" value="1,3-BETA-GLUCAN SYNTHASE COMPONENT FKS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741">
        <property type="entry name" value="LYST-INTERACTING PROTEIN LIP5 DOPAMINE RESPONSIVE PROTEIN DRG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14288">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23605">
        <property type="entry name" value="FKS1_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02364">
        <property type="entry name" value="Glucan_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01205">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="538"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="577"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="610"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="660"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="723"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1348"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1405"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1436"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1491"/>
            <end position="1511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1518"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1602"/>
            <end position="1628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1649"/>
            <end position="1672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1692"/>
            <end position="1715"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1727"/>
            <end position="1746"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1788"/>
            <end position="1809"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1846"/>
            <end position="1870"/>
        </location>
    </feature>
    <feature type="domain" description="1,3-beta-glucan synthase component FKS1-like" evidence="13">
        <location>
            <begin position="343"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="63"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="142"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1898"/>
            <end position="1947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1922"/>
            <end position="1947"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI07608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1947" mass="221420" checksum="D19FACF81CD17049" modified="2018-11-07" version="1">MSGYPGGHHDHYDDGYGHQGGGHTNSYYQDDQYYDNGYDARGGHAGQGGHGGNAADGYYDESGYYNADPNNPYHQNGGYYDGHDQYQDEYYNGQGGYYDNEYNNGYAAHSGRHGSEEDSETFSDFTMRSDMARAAEMDYYGRGDERHNSYGDGQQGYRPPSSQLSYGANRSSGASTPNYGMDYGNVLPAGQRSREPYPAWTSDAQIPLSKEEIEDIFMDLTAKFGFQRDSMRNMYDHLMTLLDSRASRMTPNQALLSLHADYIGGDNANYRKWYFAAHLDLDDAVGFANAKSKGLRRKAKNKKKKAGGDAANEDEALQDLEGDNSLEAAEYRWKTRMNRMSQHDRVRQIALYLLCWGEANQVRFMPECLCFIFKCADDYLNSPACQALVEPVDEFTYLNNVITPLYQYCRNQGYEILNGVYVRRERDHKHIIGYDDCNQLFWYPEGIERVVLQDKSKLVDVPPAERYLKLKDVEWKKCFFKTYKETRSWGHLLVNFNRIWIIHLTMFWFYTAHNAPTLIVGPKYEQQANNQPDGSKQFSVVAFGGAIAALIQILATLAEWAYVPRRWAGAQHLTKKLLFLILIFAINVGPGVKVVKWSTPKKKGSIDIDLIIGIVHFVIAVVTFLFFAVMPLGGLFGSYLTKNSRRYVASQTFTASYPKLSGNDMAMSYGLWLTVFGAKFGESYVYLTLSFRDVILFVSIFHPKCQGDHILGKSATILCENHPAILLGLMAFTDLIFFFLDTYLFYVLLNTIFSIARSFYIGSSIWTPWRNIFSRLPKRIYSKVLATTDMEIKYKPKVLISQVWNAIVISMYREHLLAIDHVQKLLYHQVPSEQEGKRTLRAPTFFVSQEDHSFKTEFFPNHSEAERRISFFAQSLSTPIPEPLPVDNMPTFTVMIPHYSEKILLSLREIIREDEPYSRVTLLEYLKQLHPHEWDCFVKDTKILADETSQMNGDFEKGEKDAAKSKIDDLPFYCIGFKSSAPEYTLRTRIWASLRSQTLYRTVSGFMNYSRAIKLLYRVENPEVVQMFGGNSDKLERELERMARRKFKIVVSMQRYSKFKKEEMENAEFLLRAYPDLQIAYLDEEPPVAEGEEPRLYSALIDGHSELMENGMRRPKFRIQLSGNPVLGDGKSDNQNHSLIFYRGEYIQLIDANQDNYLEECLKIRSVLAEFEEMKTENVSPYTPGVKNDFSAPVAILGAREYIFSENIGILGDVAAGKEQTFGTLFARTLAQIGGKLHYGHPDFLNGIFMTTRGGVSKAQKGLHLNEDIFAGMNAILRGGRIKHCEYYQCGKGRDLGFGSILNFTTKIGTGMGEQMLSREYYYLGTQLPLDRFLSFYYAHPGFHINNMFIMLSVQLFMLTLLNFGAFRHETIPCDYNRNKPTSDPLFPTGCANTDAVMDWVQRSIFSIFFVFFLSFVPLIVQELTERGVWRALVRFLKQFFSLSPFFEVFVCQIYANSVQQDLSFGGARYIGTGRGFATARIPFGVLYSRFAGPSIYFGARLLMILLFATVTAWQAALTYFWITLLGLTISPFLYNPHQFAWNDFFIDYRDFLRWLSRGNSRSHASSWIAFCRLSRTRITGYKRKALGEASAKMSADVPRAAIANIFFTEILTPLMQVVWTLIPYLFINAQTGVLPDKGTNGKVGPTDSLIRVLVVALAPIGINAGVLAAMFAMGCFMGPVLSMCCKKFGTVLAAIAHGTAAVFMLIFFEAMFVLEGFNFARTLAGMIAVVAIQRFIFKLIVSLALTREMKTDQSNVAFWTGKWYSMGWHSMSQPAREFLCKITELSMFAADFILGHWLLFLMLPVILIPQVDKLHSMMLFWLRPSRQIRPPIYSMKQSKLRRRRVVRYAMLYFVLLAVFLGLIVGPILASSKIDPKLLKKIGDSASKSVKFILMQPNHQDKDNTNGTEETGTGRPGYSGAFTKSTTKTGASEPTATGGTNNRIKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L022</accession>
    <name>A0A367L022_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_5705</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000024">
        <property type="protein sequence ID" value="RCI07779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L022"/>
    <dbReference type="STRING" id="1330021.A0A367L022"/>
    <dbReference type="OrthoDB" id="166907at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19496">
        <property type="entry name" value="Elp5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019519">
        <property type="entry name" value="Elp5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15641">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15641:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10483">
        <property type="entry name" value="Elong_Iki1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="284"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="336"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="350"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI07779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="361" mass="39123" checksum="69F1EC9561C7B1C8" modified="2018-11-07" version="1">MASAKKANAHGRAHSLLLLTRLLNLRDGASPLTLVLDDLEQTAGPVLAEFFIRAKAPNTTPILLFHPKTKTSANGYHQVTKTKLILASFTTASKPRHVDVMVKAAGRGLDDVKRQLTAHYPTQDPKQPPGTKLTHRAIVVIDSLNSLASTESVSLARFLSSLATAAVSIVAVYHTDVPVVLPRTCSEYQPTPLAIFSHLATAILKPSSLRQQIARQAARNRALQEPEWGLREGREGAIIGVRNGSSDADDDDGIVINMELRRRSGRAVLEKFILTPAASGPGRVSLLTDHPSFAPAAPDEGDKETPESTFDLGLTEKQRKDRAGVVLPYFDAQTDIGSGEGGRILYDMGREDDFDDEEDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L077</accession>
    <name>A0A367L077_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000023">
        <property type="protein sequence ID" value="RCI07811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L077"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI07811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="121" mass="13704" checksum="1AE18DA191A96B0C" modified="2018-11-07" version="1" fragment="single">DHPESAGPIHHLNPTPGRRQKAEAHGVPQEGRADDRRAANRLMALPSQRSTRTRTRYLTMSPSSRHANRSNRQRQPSATLQATSATSAMRQAKEGEIFSPQVFFFFFFKGGEEERRVFLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0R9</accession>
    <name>A0A367L0R9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7886</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000022">
        <property type="protein sequence ID" value="RCI08011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0R9"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="138" mass="15869" checksum="E277D77FD2A27304" modified="2018-11-07" version="1" fragment="single">RPIDSLQRSSQRSARCTYSGHSTRLISAQGSRHIDRRAVLIAVIALDQSSQRNRHSDRRAVLIAVIAPDLDSRTKEGGFPTYFQFIISFNFITSSIQSPLLPSILLQSSQNHHYVIRLLLLYHVIYTLITHHYFHCRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0X4</accession>
    <name>A0A367L0X4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000022">
        <property type="protein sequence ID" value="RCI08061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0X4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="250" mass="27049" checksum="7331F0BAC41E27BC" modified="2018-11-07" version="1">MIANAEKQALIEERDSYRTKVVADLQGDFASAGKASTISGFVVVVVVVVPTGSVLLLSTPLTLTLTLSQNGKRHSPNPRGGGTWRLGRGPRIDHAQGFGEPLENGPVSLLLQPKSHYGLKEADVIRSRPAFLASSSFNLCSSSETVPSNGQEPHGGYGHETPVLARQRRLYGYVSQPVTTAYHGLPWLKAYCVLSASVLAARAADRDTFMSRRGIQLDDTQQNVVCIAGHGLRRDKSRPTGDRRSMRAFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L143</accession>
    <name>A0A367L143_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GDP/GTP exchange factor Sec2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_6298</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L143"/>
    <dbReference type="STRING" id="1330021.A0A367L143"/>
    <dbReference type="OrthoDB" id="5560525at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070319">
        <property type="term" value="C:Golgi to plasma membrane transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040351">
        <property type="entry name" value="RAB3IL/RAB3IP/Sec2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009449">
        <property type="entry name" value="Sec2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430:SF4">
        <property type="entry name" value="GDP_GTP EXCHANGE FACTOR SEC2 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430">
        <property type="entry name" value="RABIN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06428">
        <property type="entry name" value="Sec2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144284">
        <property type="entry name" value="Sec2 N-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDP/GTP exchange factor Sec2 N-terminal" evidence="4">
        <location>
            <begin position="175"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="97"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="51"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="193"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI08117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="270" mass="29385" checksum="74A34063BC920792" modified="2018-11-07" version="1">MSSTAVLTMTTPPLPRTTTTTSTTSTPMTPPSSSSTTTACCPACGIGLPPIDQTQAELLVARARIHELESQVRQLNHKASVAVERWAAYEAELSRLRATTTTTTTTTTPSSSSASPSSMLKLDPAATPSPTRTSFLQSAPSRLSSLLYPRKSTPSLRVDTPSVAPAPASATTTVSSSATEDLLEALTREQMLRREAEGRLSATSKEVEELSASLFEQANGMVADERRVRARLEERVDVLEKRDLEKRRRLERLEVAMRRIEKARDLLTDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L198</accession>
    <name>A0A367L198_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAR-17a/AIG1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000022">
        <property type="protein sequence ID" value="RCI07992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L198"/>
    <dbReference type="STRING" id="1330021.A0A367L198"/>
    <dbReference type="OrthoDB" id="419711at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12242:SF1">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12242">
        <property type="entry name" value="OS02G0130600 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI07992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="33449" checksum="79DB845B73E519B1" modified="2018-11-07" version="1">MGRRCFAFGAGPWDPDHRFETSSLVRPWTLFLCRAAMCIYAFFTIFFIIIFNCTAQSSPPTPSPSQKPTTTAAKDTTTGCASVPRSFSYFTVLCYWGLAFYFLFASLHTFSYARTARPLLLRFSRPLQALHALLYSSIVVFPFIVTLTYWAVLFRSRFPTTFDAWRDLSQHALNSIFALFEIIVPRTSPLPWLHLLWLAICLLAYLAVAFITLADQGFYVYAFLDYRQAGGRAYVAAYVLGITFALVLIFCAVHFLIRLRCWMTESKLQLAAKYAREPVLVADVEVADVETKAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1J4</accession>
    <name>A0A367L1J4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_8350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000020">
        <property type="protein sequence ID" value="RCI08310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1J4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI08310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="77" mass="8730" checksum="DE85366C976D5948" modified="2018-11-07" version="1" fragment="single">VGKKDPNEVICIPSQRAEPGLITSKGYTSKELEAGEVGKPSFFYRQCLRNKEEDLYVPYPAVSAVLRGVWVRIRLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1T6</accession>
    <name>A0A367L1T6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Elongation factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_8899</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1T6"/>
    <dbReference type="STRING" id="1330021.A0A367L1T6"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16261">
        <property type="entry name" value="EF2_snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000010">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000006">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000003">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000058">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF10">
        <property type="entry name" value="EUKARYOTIC TRANSLATION ELONGATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="17"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI08400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="844" mass="93441" checksum="E47C09645289A325" modified="2018-11-07" version="1">MVNFTIDEIRALMDKPSNVRNMSVIAHVDHGKSTLTDSLLAKAGIISTAKAGDARATDTRPDEQERGITIKSTAISLYGHLDDPEDIKDIVGQKTDGQDFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDTVEGVCVQTETVMRQALGERIKPVIIINKVDRALLELQVSKEDLYQSFSRTIESVNVIISTYLDKALGDVQVYPYKGTVAFGSGLHGWAFTVRQFAVRYAKKFGVDKNKMMERLWGDNYFNPHTKKWTKSDTYEGKPLERAFNQFILDPIFKIFSAVMNFRKEETATLLDKLNLKLSTEDKQKEGKQLLKAVMRTFLPAADSLLEMMILHLPSPVTAQKYRAETLYEGPMDDVAAIGIRDCDPKAPLMLYVSKMVPTSDKGRFYAFGRVFSGTVRSGLKVRIQGPNYVPGKKEDLFIKAIQRTVLMMGGKVEPIDDMPAGNIVGLVGIDQFLLKSGTLTTSDTAHNLKVMKFSVSPVVQRSVQVKNAQDLPKLVEGLKRLSKSDPCVLTLHSESGEHIVAGAGELHLEICLKDLEEDHAGVPLIISDPVVQYRETVQSKSSMTALSKSPNKHNRLYMVAEPMEEELSLAIESGKVSARDDFKARARVLADDFGWDVTDARKIWTFGPDGTGANLLVDQTKAVQYLNEIKDSVVSGFQWASREGPVAEEPMRSIRFNILDVTLHADAIHRGGGQIIPTARRVLYASALLAEPALQEPVYLVEIQVPEQAMGGVYGVLTRRRGHVFSEEQRPGTPLFNIKAYLPVLESFGFNGDLRQATSGQAFPQSVFDHWQILPGGSPLDPTSKVGQIVTEMRKRKGIKVEVPGVENYYDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1Y4</accession>
    <name>A0A367L1Y4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1Y4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="128" mass="14076" checksum="9FF780F7EBD7755F" modified="2018-11-07" version="1" fragment="single">YGWKVTPILRPYLRSLGIGAQGRTVSACNRLAPPRPATNLPPLFLTHPRHQLLESLHVRETASSHGETPLRICCSNGPPDDAPEAAEARPVPRLSPRRHPDHRASIAAYCPRRMECCAGFHTTFGTPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2D4</accession>
    <name>A0A367L2D4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="6">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_4690</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="6"/>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2D4"/>
    <dbReference type="STRING" id="1330021.A0A367L2D4"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071474">
        <property type="term" value="P:cellular hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000433">
        <property type="entry name" value="MAP kinase kinase PBS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013:SF25">
        <property type="entry name" value="MAP KINASE KINASE PBS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="236"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="158"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="581"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="100"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="279"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="602"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI08591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="615" mass="66368" checksum="B18E2D33FD816BC8" modified="2018-11-07" version="1">MSGHGSPATPDEPLSDQDVDSSSDTVAESPSETTKRMPSLRSVSDPPNMNPNSTARGLLGRARNPNQSLPSLAADNSVMARARALHQERMQRGNMAPANSPRGSSSPTTPGVSPDGFAGRLRMPAPLQRPGLGPHPKSAPMIPQPSLGQRRANKLAMGMKLPGGTPSPGFRLSDITGDQSGDQTTNGAAQRSKMDDFKQYIDAEKGWITFDGAATIMRTGVSFANGHTFSISLDEVEKLDELGKGNYGTVYKVRHAKPALPRFGPGLSATRLHHAHSDPSPTRRQVENNTTTGKVMAMKEIRLELDDAKFTTILKELVILHECISPYIIEFYGAFFQEGAVYICIEYMDGGSIDKLYDGGIPENILRKITYSTVMGLKTLKDDHNIIHRDVKPTNILVNTRGQIKICDFGVSGNLVASIAKTNIGCQSYMAPERISGGAMAQSGNADGTYSVQSDIWSLGLTIIECATGRYPYPPEVSSTIFSQLSAIVEGDPPDLPKEGYSETARDFIRGCLHKMPMMRATYAALLNHPWLKPLSKPHTITEEVEDCEEAETIAEEVGKMQLSGDNTEDVEVGDWVKSVLKRKDEGSDDNGPSRPALHTAPLTSVGSNGSASDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2H7</accession>
    <name>A0A367L2H7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_4888</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2H7"/>
    <dbReference type="STRING" id="1330021.A0A367L2H7"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20568">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20512">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="402"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="7">
        <location>
            <begin position="495"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="499"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="123"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="266"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="627"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="644"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI08607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="653" mass="72730" checksum="3FF452A7C539DDB6" modified="2018-11-07" version="1" fragment="single">MDARSYRSRGAENAVPSHHQRNKSAGNIAAMPLAPAAAGLRGPAKRAAFGDLTNTTKSVVPPRDEVKAAAIKVQAVLPSNGPVAYNTYNHSHNHAQIYTSQPSHNGNGGGAKAIQPKKEAFLRPPHRPANLASKHRDGVDSRQTTAKPVPAPLHTTSQTHLGKEGFPQETSEEAGASLEGFPLQPRHHKSQPQLKAQQPMLRRTQSKQLDGLEAARSSFVNPGGMPSRGVVVPADYAGQLYPALDREPVAEPQGEAEYGRKVTEVPRQAPVSGGDGQTAALSEPEDCWDEVDDEDYDDQDQAYTTAHSLRCRDMTTGGVTTLLAPRVTAKVQRELEEARLEVQLTRAADDIEEELWDVSMVAEYGEEIFEYMRELEIKMLPNPHYMEMQTEIQWSMRSVLMDWLVQVHNRFGLLPETLYLTVNYIDRFLSCKVVSIGKLQLVGATAILVASKYEEINCPSLEEIVYMVDGGYSLEEILKAERFMLSMLSFELGWPGPMSFLRRVSKADDYEVETRTLAKYFLELTIMDERFVASPPSFLAAGAHCLSRLILNKGDWTKLHVHYSGYTWSQLKPLVAMLIECCDRPRLHHSAVYEKYKDLRFKEASTLVQRALDAGFTLPLHVLPVRRSQQRPPPPVEEGSLPGEESRALDEYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2L1</accession>
    <name>A0A367L2L1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_4796</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2L1"/>
    <dbReference type="OrthoDB" id="5426678at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI08648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="237" mass="26359" checksum="06E7863E62DA6BF2" modified="2018-11-07" version="1">MPPRIQVRDVETPLPPGTIVGIVIGVVLIFALAALLFIIYYRREASMDELDDSSVATTTGECRERGVMRGDSQLFGSSGDYYDLVNRHVVVQAPLNPDNAMPTHPAYIPTSSWPVIRPPPEPPSSVPVRSNRPDSYAVQAYLAAAQESARMAPPPAAVRTGTERRTSRSFALPLASLPRIAVPRKQTRAETEPHERLRHHSPPVTEWRSSSRQRNHHDDDNFFEVPLRSGKSTLYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3H9</accession>
    <name>A0A367L3H9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_5017</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI08985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3H9"/>
    <dbReference type="STRING" id="1330021.A0A367L3H9"/>
    <dbReference type="OrthoDB" id="3162439at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF2">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="2">
        <location>
            <begin position="34"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI08985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="523" mass="58994" checksum="5FE18464653A3FEA" modified="2018-11-07" version="1">MATLTTRSPLTAEGSSATLLGMDTSQPEPRPQPKKLVLFFDGTGNSFSGSTADTNVIKMMNKLARSDRHQLHYYQTGIGTYDIRNEGSVDKNWFSEKWSSLVQMLDQGFGTSFGAHLMAGYRFLMRYYNTGDKIYMFGFSRGAFVARFLARMLCTVGLLCKGNEEMVRFAYRLYRRFLDGEAGKGAVQDEVDAFSRTFCRREPVPGGKGKKADDNVRVYFLGIWDCVNSVAVLERNAPLAQTVYGTADHVRHAVAVDERRVKFRAALLAQDVRVAASNDDCKDDIREVWFPGCHGDVGGGWPAEKAADSGGLDDSDKGIGKRFRRILRTRRSFGTSPDAGHDDFQMSDVPLAWMMRELDEVAKLDQSAGLKFGPSAQGFHSRYTKNKEQTRLSVLHDSLRFGHGTGFFRVLLWRFLEWLPFVSRRELVNNKWVDKRFPPNFGSTRDIPRDAVLHESLVHRLKTNRSYKPPNNHGDDLQPCLKVDGKAVEFELVGNCHPEHPTYIFRRKTQTNGQTNGQTTNGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3R6</accession>
    <name>A0A367L3R6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Increased loss of mitochondrial DNA protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI09048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3R6"/>
    <dbReference type="OrthoDB" id="5299849at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018815">
        <property type="entry name" value="Incr_loss_mito_DNA_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28029">
        <property type="entry name" value="PROTEIN ILM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28029:SF1">
        <property type="entry name" value="PROTEIN ILM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10311">
        <property type="entry name" value="Ilm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="21590" checksum="B0A047C052934931" modified="2018-11-07" version="1">MPLIASKTIITSLSLFHITLAFFFLTNPRRIHDQILVYVLGESMGMPVARGFDAQSPPLAFLAAVLAMFGFSDLFALSMPEELASLYYWGVQAPLRSLFSIVLVFYSYFLGPSSPVYGSSAPRSTSRPSSANHTPYRSSTWGGDGLKNRIFFTFIFLEMITWFWIWVTLREERHGVVQRMRKQHPRHEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3W0</accession>
    <name>A0A367L3W0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_4960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI09110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3W0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI09110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="95" mass="10744" checksum="3544AE67F9E2A0ED" modified="2018-11-07" version="1" fragment="single">MELLLRRRLELFLCAYAGLGYIMDLMHFVELHLYSAISYYSHTIVLILHRSTDYLCSQVRLKIPSARCTVEGLAGTSWLILASPAVEITSASPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3Z2</accession>
    <name>A0A367L3Z2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit F</fullName>
            <shortName evidence="4">eIF3f</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_1448</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit F family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3Z2"/>
    <dbReference type="STRING" id="1330021.A0A367L3Z2"/>
    <dbReference type="OrthoDB" id="25498at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08064">
        <property type="entry name" value="MPN_eIF3f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000019">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03005">
        <property type="entry name" value="eIF3f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027531">
        <property type="entry name" value="eIF3f"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF6">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="6">
        <location>
            <begin position="31"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="316"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="316"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI09141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="354" mass="38678" checksum="46AD2F8AE2E6F990" modified="2018-11-07" version="1">MAAATERFIHLARPLSHSNVGLQTNIAPLSVNIQPQAVLSILDHAVRRDVRENAQSTRVIGALVGTRSEDGTEVEVRSCFAIPHTEEEDQVEVDVDYQKTMLALTLKASPRESLLGWYTTSHELNNFSALIQNFFAQPETGTFPHPAIHLTISTDPGEEIETRCYISAPVAVNAERAAESCLFIQVPHKMLYSDADKSALEALASTQDVESRTAPLVSDVEGLGRSMEQTLNLLDRVSEWVNGVLDEEEEPNNALGQYLMSALSLAPKVDDSQIEHDFNNHVQDVLMVSYLANTIRTQIDLSQKLAVANLTSVDKDVDGKNEGERGGNQRGGKRGGRGGGRGGGQSREPREPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4B0</accession>
    <name>A0A367L4B0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Indoleamine 2,3-dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_1572</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the indoleamine 2,3-dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4B0"/>
    <dbReference type="STRING" id="1330021.A0A367L4B0"/>
    <dbReference type="OrthoDB" id="10262710at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.480:FF:000005">
        <property type="entry name" value="Indoleamine 2,3-dioxygenase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000898">
        <property type="entry name" value="Indolamine_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037217">
        <property type="entry name" value="Trp/Indoleamine_2_3_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28657:SF3">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01231">
        <property type="entry name" value="IDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140959">
        <property type="entry name" value="Indolic compounds 2,3-dioxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="720"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="795"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI09257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="815" mass="89028" checksum="5E88CC3661E76ABB" modified="2018-11-07" version="1">MGSITNPPFQVLDDTRPQDKSLPAFMVSRTRGFLPRMDPIVKLPADFDALESILQRMPVKTASGEPGLLALNKLGPEVDSQLPDLTDVMDRYEDHLPLMNALYRDYSFLASAYLLEPCHERFVKGEPYGLGRQVLPRNISRPIARCAEICGFKPFMEYAGSYALFNYRLEDPEAGLDYNNLRLIRAFEHGLDPSSSEAGFVLVHIDMVKHSGPLVAGAMDCLDVAASRLGSVEERTALNKGLSAMLSAMVSINGVMETMWAKSRPTEYTSFRTFIFGITSQSMFPNGVVYEGLNDDQPLSFRGESGANDSMVPLMDNLLQVPMPDTPLTQILKDFRQYRPSNHKAFLQFVKDKSLEVQLKAFALAPASAAAKTTEEEEEEEELIRESRSLWLQLLNQVRDFRWRHWCFAREYILKRTSHPTATGGSPIVTWLPNQLEAVLEEMAQLYASSEGLGRTCDDIMESAMRQRETLRKEVDKYCAERASYGRDSLSRPCPLFTIIHQSAMKTALICLVVVVVVVVVVAVAGERTPSAAPPPALVPRRSDLVPRSVPAPRQHVVRRAVGDDGLCRQGSHNCLDIGHADQCCHDDSYCYVNRNYEPRCCPVGSNCVDDSPCKSDGFFCSKPADGIGCCGRLCPQTSHYLCPQSLGGRCCPYGAQCQLGGNCLQTKTSMTTTTPPPPVCSECADGTGCCRLGQRCTRVSETAYCAAAAPLEQGLSRGALAGIGVGAAVAISVVMAAAAWVCLSGRRRDEDELRIASTSPRLGLTEDYSGPSPVSGPYTEAAVPSATRLLGGLPRAVPTRPHGPGDIAAPVEMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5G5</accession>
    <name>A0A367L5G5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">ER membrane protein complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_3830</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5G5"/>
    <dbReference type="STRING" id="1330021.A0A367L5G5"/>
    <dbReference type="OrthoDB" id="6745403at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008568">
        <property type="entry name" value="EMC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002809">
        <property type="entry name" value="EMC3/TMCO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116:SF5">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01956">
        <property type="entry name" value="EMC3_TMCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010045">
        <property type="entry name" value="DUF850_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01415">
        <property type="entry name" value="DUF106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR010045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI09676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="260" mass="29348" checksum="2C50E9CA6F03DF91" modified="2018-11-07" version="1">MAQVPVQTLHRDPQLFYWILIPITVVMILTGVLRHYASVLMSSAPKRLDAKTMREQRALARGLALRSNFHVLSQRAFESRRQTLADGYESGAFLKDPDRKGQPPANPLSDPSQMDGMMSMMKNNMAMIIPNTLIMSWINAFFSGYVIMKLPFPITLKFKSMLQAGVQTKDMDPRWMSSISWYFLCIFGLQFVYVFLLGSDNAASQMAQQMAAQQMPIGPMGGPGQDPDKQFKMEAENLAVVEHYSVLDSVEERLLQGIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5Y1</accession>
    <name>A0A367L5Y1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="11">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_4012</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">In the C-terminal section; belongs to the aldose epimerase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="11"/>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5Y1"/>
    <dbReference type="STRING" id="1330021.A0A367L5Y1"/>
    <dbReference type="OrthoDB" id="9402762at2759"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725:SF47">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="7 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5 11" id="KW-0520">NAD</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="12">
        <location>
            <begin position="6"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI09827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="383" mass="41984" checksum="5EE2D0791DE7517E" modified="2018-11-07" version="1">MAVGTVLVTGGTGYIGSFTTLALLQHGYDVVIVDSLYNSSEVALDRIELLCGRRPVFHNADVTDEKALDQIFAKHPAIDSVIHFAALKARVSPDRDARQAVGESAEIPLEYYRVNVGGSISLLRSMERNNVTNIVFSSSATVYGDATRFEGMIPIPEHCPIGPTNTYGRTKAGIEDVITDFINAQRNNLKKAGKPYEQWNGALLRYFNPCGAHPSGIMGEDPQGVPYNLLPLLGKVATGEREKLLVFGEDYASDDGTAIRDYIHVMDLAKGHLVALNYLREKKPGVKAWNLGSGRGSTVFQMIKAFSAVVGRQLAYEVVARRPGDVLNLTANPSLANKELGWKTEIPMEKACEDLWRWVENNPQGYRQEPPKELLAAVKAPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L640</accession>
    <name>A0A367L640_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_8427</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI09887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L640"/>
    <dbReference type="STRING" id="1330021.A0A367L640"/>
    <dbReference type="OrthoDB" id="28755at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008506">
        <property type="term" value="F:sucrose:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432:SF35">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 45 MEMBER 3 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19432">
        <property type="entry name" value="SUGAR TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13347">
        <property type="entry name" value="MFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="523"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="452"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="545"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="461"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI09887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="567" mass="60849" checksum="AF6FE6A45671B463" modified="2018-11-07" version="1">MSPPTADETAPLLPLNNDAEALASRDAEHGRPTNGLLYMTLLTLGFGGLQIAWSVELSHGSPYLLSLGVSKSLMALVWIAGPLTGSIVVPYVGILSDNCRLPWGRRRPYLVGGTLGTVASLLLLAWAREIVGGISSLFGRTDASEGGGGGDVVVVVVAVVGIYLVDIAINTVQAALRAFVVDCAPPGRQELANSMAGRLTGVGNIIGYVAGYSDLPSRLPFLGRTQFQILCAIACLALSVTITLSVFFIREETGEGRPPVKTPGIGPFFFNLMRRSVRRLPPQTKRVCRVQFCAWIGFFPLLFYSSSYIAEIYVQPFLRARPDMTREEVEVLYQQATRIGTFALLINAIVSLSTNVFLPFFITPSLDDERKEEAEQGAFLFSSARWLRIPGLTVKRAWIGSLVLFALAMFCCPFVSSVEAATALIGVAGITWAMALWAPWAIIGAEINRRDGKRQSSPRQEDDEGEADEALGEEEEEEGDEAGVVLGIHNMAIAVPQIVATVGSSIIFKLWQKPRGTPGDGSIGVVMALGGACVLLSVLFAAGIDDDDDDDDDDDGDDEDDEVGGMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6Y7</accession>
    <name>A0A367L6Y7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PABS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_8667</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6Y7"/>
    <dbReference type="OrthoDB" id="2016285at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000288">
        <property type="entry name" value="Spermine/spermidine synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051419">
        <property type="entry name" value="Lys/N-term_MeTrsfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037959">
        <property type="entry name" value="MFS_SpdSyn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176:SF59">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI10193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="588" mass="64777" checksum="353EBD2DECA1C51B" modified="2018-11-07" version="1">MSSKRTTTTPDMAAKRSSTAAGGFTPEHFEAELKDLAAKARDDSSGKHVVEQLALYAKAVVLLALLGIYSVVSPLNLSPVYGTLPASLWHPQLLMIGCFIGWAGNVAFRNLLPVKTAHLLPLVALYIPTMQWFLFGYSSLLGPRWAPIVTESLTFVPLSALTVAAVADLVEGTRLPLLPGFVADAAPGLGSWAWLKFVELLAGRHLPPNMGRFFLLTRIGLELMLGGLYALFARSRLLLYVLPPLLHTLFLNAHLASPAATSSLVSSMLSDNWLLLDRRESVTGYVSVLQSMEQGFRAMRCDHSFLGGDWIGERGRTLSEPIYGVFAMLEAVRLVERASPLPDQEARALVVGLGVGTMPSALVTHGINTTVVEIDPVIYEFAVKYFDLKENNAPVLEDAVSYTSALAAAAPESYDYIIHDVFTGGAEPVQLFTLEFIQGLHKLLKPDGVIAINYAGDLLLPAPAVIFRTIKRVFPTCRVFREVPLDAKAIESDGADFANMVIFCTKSDAPLMFRKPTAADYLESLTRKQFLRLDHEMLEAEFLSTYEDDDTILRRNDTSAVEKWHEKSALGHWAVMRRMLPASVWERW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6Z2</accession>
    <name>A0A367L6Z2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_8683</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6Z2"/>
    <dbReference type="STRING" id="1330021.A0A367L6Z2"/>
    <dbReference type="OrthoDB" id="3647at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF110">
        <property type="entry name" value="RHODANESE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="60"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI10200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="272" mass="30177" checksum="3BD772E980B245C9" modified="2018-11-07" version="1">MHTGFIHDASYPSRNIMDTTNQYNIIGTDYTRYTEVTIPHAKLVAELVGKALGDCRGLSVLDLGGGNGLHARRALAAGAEYVDLVDISERMIEIGKRKGGGDGERIRWCLADATKPLPQQCQLTSPDGKYDIVMGNWLLDSAVKSEQDFEPLWRNIIDCIKPGGKFVGVRSRYPGFCGKAGRVKYGLTWADIKDIPGGWRYRVMVHVDPPFTLEATTMRDSATLANEVPTRLGLADFEAVPIEETEVYKADPDYWTVMREEPMLAVVVARKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L730</accession>
    <name>A0A367L730_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_8531</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L730"/>
    <dbReference type="STRING" id="1330021.A0A367L730"/>
    <dbReference type="OrthoDB" id="4928261at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="34"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="737"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI10237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="779" mass="89998" checksum="6103D3D1761D7151" modified="2018-11-07" version="1">MSCGWIRVMKLFPGAWNDMIEFELSPPMMAPPSYKVLSYVWGSRNNKRPIYLWDSWTRQRSVVYVTVNLDHALRRIRRADSHLTLWVDAICIDQTNVEERSIQVQFMRDVFAKSEEVVVYLGEPRVMDERLVVSPPSVFHLDDRDFQHMAGFKDRLASGGKGGQDMDVGLDVFCLVRVLADQAADNCWPQLGKDAVYQGNLFEALRQFMQCKWWSRVWTVQEIIVPREVTVYYGGAVAPWHMFVTAARCYRQDCLPLIHEYRCVADDFSERILEVEKRRERWRKLDRSDLLSLLRQFGDRQATEPRDKIYALLGLSDAGSSMIPDYSLPISRVFQNTVLYIIRQSQSLDVFLGDVGRKVDDALPSWVPDWTAVARDELDRLRVENIRYFNAGLGSDTGSKTCQWCETLRNRYTHHAAFMKWLTSVRYRRDMVEEDGLFDWLCTIHTGRVRVLKEDDGVISMPGLYVDTVAVVGDPMLSTDTLWTLLSWAKIVTERFSRREHRPRGQELGHVFGRALCADTITVHNQTRRLNTTDTRALARWLLNTDRGTEKLDINHVLDMSGDIYQAIRVATHKRRLFITSTGYIGLGPTKTQVNHFVYVVPGSKTPFVLRNAGESRGEAGLELVGDCYAHGIMDGEATQQRRLELSWRLQEVAIKAKWTAEAEAESVMSLMADAQVELQDKQPDFEPWRCENLEVQQREIERRLCDAGDSLQAAADSWRKSARWERWLSSGSCQDMTTQGQREELWSSKRSHRRWEKRRLGATLDEVEEDVEDWSPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L768</accession>
    <name>A0A367L768_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_8577</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L768"/>
    <dbReference type="STRING" id="1330021.A0A367L768"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF98">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="59"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="485"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="397"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="486"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="538"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="660"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="671"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="689"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="741"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="757"/>
            <end position="770"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI10273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="782" mass="88170" checksum="B0067FD5C8AB2B17" modified="2018-11-07" version="1">MGDGWTTVGPGIPRLCLCEADQDLRERKVIDNWARDHDWPGIDKPPPPDFDAKRFDARLSKLDHLGYGRHGCVDKVIHDAVLLARKRILRPRNRTINDLRQEGLTMAKLDHRHVVKLVATYEPRRFELCLLIWPAAVCSLTVLLDDVEALRAGDGDIEDITARLAALRLSPDDKGPLDFLAALLGCVARAMAYCHAQGVRHLDIKPHNILLKPDRVYLADFGISRDVTGQDHTTTDELPGTEKWRAPELYGHHGSSMQLSDMYSLGLVFLNVATVLYGARQADFDDAVRWSASPSFQDSLSLREDKIKRHLERLATQALVTPHLIFTYDGQETVRPRPIVNLISHMVTSNPRGRLSAEKVDEKLSTLGGIRQMYHADCCKRPISWVEDKWDRKLTALASLKEKNEQQRKRIKELEGKDETYEARIDNARKSHEQDISRLQALLREAENKCQRLELEKATRRNLHNTEAENKCQRLELEKATRRNLHNTGGQQGTHSRSAIMPAGGGQRRDGSPATSSPKPPWPASPLQIARRPGHHYQQQQQQQQQQQQQQQQRQQQRQQQRQQQQRQQQHQQLLLQLPWTASPDSSTVRAGPSPRRPNMSQPHPVRNPLNQDQDQDQDQDQRWSPSVTGRAEHGLLRSRGSGSRLPLPVTPGRGDAATPVSSNLNFFEQSMTDSSMTSSISSRRSVETAPTPTDGSPQLQREHQQQRTKQWTELPPRQRDRRAMGSKPMLSMTSAASSPRALRSGLAGAGADSDGSTAQPVIPSLQSAKSWADVAKLEKQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7Z5</accession>
    <name>A0A367L7Z5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Kinetochore protein Spc24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_4283</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Chromosome</location>
            <location evidence="11">Centromere</location>
            <location evidence="11">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the SPC24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7Z5"/>
    <dbReference type="STRING" id="1330021.A0A367L7Z5"/>
    <dbReference type="OrthoDB" id="3344830at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11565">
        <property type="entry name" value="RWD_Spc24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013252">
        <property type="entry name" value="Ndc80_Spc24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038066">
        <property type="entry name" value="Spc24_Fungi_globular_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22142">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22142:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08286">
        <property type="entry name" value="Spc24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143026">
        <property type="entry name" value="Kinetochore globular domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 11" id="KW-0132">Cell division</keyword>
    <keyword evidence="10 11" id="KW-0137">Centromere</keyword>
    <keyword evidence="3 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5 11" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI10534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="215" mass="24393" checksum="7F560D023CA5F559" modified="2018-11-07" version="1">MLLAEDPATLINHTINNFNIQPDKQAVARINESLLTLQQARDLHIRDAKSTLRRLCRQQGSLTAQHEELVAAHKEANHASHISALDTKKFRTAKAASDAESETERLVSAAADLGARLHELEVQGEDAAVEFSSSSSSSSTSMTSRRKVRRDAVDDEILLRLKIYRSLGIEIERDEKEADWSRAVIRNDRKADMHVVNLDKKFSRFFYASYFWQML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L890</accession>
    <name>A0A367L890_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_4460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L890"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI10636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="91" mass="10400" checksum="EB95C1388BFB6CFC" modified="2018-11-07" version="1">MLGRLATRKIFDVLQLRLRKQHKGIPILIDRKAPRKRLSSRQLTFIVDLTLNFGRISLKSPIMLAFLDTSAETNILTTSAARDLNLECRPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8N0</accession>
    <name>A0A367L8N0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_5341</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8N0"/>
    <dbReference type="STRING" id="1330021.A0A367L8N0"/>
    <dbReference type="OrthoDB" id="29879at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010961">
        <property type="term" value="P:intracellular magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12829">
        <property type="entry name" value="Alr1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000027">
        <property type="entry name" value="CorA family metal ion transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044089">
        <property type="entry name" value="Alr1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535">
        <property type="entry name" value="MAGNESIUM AND COBALT TRANSPORT PROTEIN/MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21535:SF55">
        <property type="entry name" value="MAGNESIUM TRANSPORTER ALR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="808"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="89"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="333"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="418"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="218"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="370"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="418"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI10771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="833" mass="93519" checksum="0651CFDBA9D433B8" modified="2018-11-07" version="1">MVKLVEQLLSHGEFPIGACTIESAAKRYGARNRDGNQRLRMKPMLVVVVVSCQSRPGPRTPGPPSGPVILMGGQRSTVRRLDWWGQQKQDPLYDGNCPQPTPGPNSPDPVKSSSWLNTPPTTTQQALRSSALAFGSTAESTRTPHNWELPCLTRKLDSGARLLRPAPSFTSSLRYDLLSLNWPLLGLGTAGQKRLYSTIPVLIRRAAEDNSSKVHSPIRNSSYQNMSEQDGTTDAGYDTPVPELDDHRHLSVVGPRNERPRRGTFDSLYGVSRLEGDVNASCIRVRDFEEAVIDEDALEVPTCVRHGRRATTDTPHDCRQPSPPNSVKAFAQARRRERDLSFSEPKNEFEEGPGRATSISSRRSLRSKSRTIENDTGSLRKNEDAEENVFLPMKEDARNNELRIDFDYLESFINAERAAQDDNRRPPVEVFEDLRTPQQESRRTQLATSDGDILDMPSEESVSNEKASAEATVKPAANHFVDKNRFSFFSSAWESTIHAAEMGDLVLPGEDIRGLFELPADEADGVWWLNVNHALKEEVQGICKAFGVHPLTIEDIITQEAREKIELFQSYYFACFRSFNVLNEPDGIEYEPFNIYVLVFREGTLSFSFAPNSHASQVRKRITALKEYVSLSSDWICYALIDNIVDSFAPVIRTLELEADAIEDEVFVMRYDDSSSFLRTIGRVRKNCMALLRLLGGKADVLRGFTKRCNENYQVTPHMDIGMYLGDIQDHVVTMATNLGHFEKMLSRAHSNYLATLSINSISQGTDTNRVLSKITFLASVLVPLNLISGVFGMNVPVPFQRSERLEPFFGIIACMILVCSLILGWARWKRYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LA03</accession>
    <name>A0A367LA03_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7703</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LA03"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI11249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="131" mass="14548" checksum="0F5C5DB2F4E3F0C5" modified="2018-11-07" version="1">MQNGENDGRRIMRWVERGHGAVRTAARLGRIGYCRNKVIKGRREMRLLAPGPSCCHWPTIVRRAAFSTRDRVARIGSTFTGGGLSFNGLDLCRYAREYPTKCPDPVGTHDDSASRPCREAVRGTVRYPAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAJ0</accession>
    <name>A0A367LAJ0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7477</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-10" db="EMBL/GenBank/DDBJ databases">
            <title>A genome scan of diversifying selection in the zombie-ant fungus Ophiocordyceps unilateralis complex supports a role of enterotoxins in coevolution and host-specificity.</title>
            <authorList>
                <person name="Kobmoo N."/>
                <person name="Wichadakul D."/>
                <person name="Arnamnart N."/>
                <person name="Rodriguez De La Vega R.C."/>
                <person name="Luangsa-Ard J.-J."/>
                <person name="Giraud T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAJ0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI11447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="66" mass="7686" checksum="05F13EBE9920BDB5" modified="2018-11-07" version="1" fragment="single">LPEPESLAKEYFWSLPIVAERGNFFKKKESRDSLKEAIEEELEAGEVFVLRRLIRVNPIDLIDLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LB97</accession>
    <name>A0A367LB97_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LB97"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI11686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="146" mass="16717" checksum="A3EC8E0D89BA3B51" modified="2018-11-07" version="1" fragment="single">GCQRSHIGIPDIRRDGFMYMCRNRDEFMPHNTNGERKAKRIRWQLVIRSAPVCLKSSSPKTEGQAASERGKLSTRCRFEKLDSQLARRSNDCFFSVYIQGCDERRDGTRTLSEARAAESDLSDTRRDSDWQSLIGASNEAARKKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBL2</accession>
    <name>A0A367LBL2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_7515</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBL2"/>
    <dbReference type="STRING" id="1330021.A0A367LBL2"/>
    <dbReference type="OrthoDB" id="4314040at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF13">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="58"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="580"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="78"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="589"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI11807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="635" mass="70787" checksum="F850BF08392C3EB2" modified="2018-11-07" version="1">MVYCGKPSRGCQMCRTRRIKCDETKPTCNQCAKSRRICPGYKDEFDLVFRNETQATKRRAKKANNKALALKHGRDADASSAAADSSLSPASSASIQAPPRVALEDQAACHFMSNFVLVPHQGSVRGFMEFLVPLMKVDRIPQHFRYAFDACALASLNNRVGTGNDFDKDALTSYTQALSATYAALRDPEVAKQDATLASVLLLGLFENISAKHIGMLAWGSHIEGAVQLAKARGRKQLRTKVGLAMFIAVRTQMVSPPLPSPYSLLLIPKAVRPVQLTCLPLTQPTQIIHCLSTSKSPTMGADWWMNDTVRDEHASECQRLNIIIGEIRAEANRLLTTSTRSSDQIDQVIAMIKRCQAHDQTCASWANDLPDCFRWKTVAWEDNVPNGDYAKADVYPGRVDAYQDLWISSIWNMMRCSRIVLASIIVRCAAWISAPVDYRTTPEYAVAARVCVDTITDIIASIPYQLGWFARRRHLLERADMSTFGCGEEDAQKGLGGYFVTWPLACVHGQDYTTDSQRAWVQGRLEFIGSHLGVRYAHILTELHVRVPSMLILRDGLVSTPYPHAQDFEKLLSSKVAASTASKSRNQTQEREAKQRETIRRQTAELVSKAMGTSGKVDEWTAKTWLQLQHLTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBY2</accession>
    <name>A0A367LBY2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CND01770-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBY2"/>
    <dbReference type="STRING" id="1330021.A0A367LBY2"/>
    <dbReference type="OrthoDB" id="2566743at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016744773" description="CND01770-like protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="132" mass="14722" checksum="1853FD8D4065B1F9" modified="2018-11-07" version="1">MFFSAGKKLFAATLALATIASTDSSVSKGKVMDFAVEKCLDSDGNVRCSKPFPVKEGSCYNLHWSTEGLVSHTTVEVRDAGSGEMVYYRDTDGEWKPEKNELVYLDFKPKVWKTGNETVEYEVKMCGKDNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCC1</accession>
    <name>A0A367LCC1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_1260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCC1"/>
    <dbReference type="OrthoDB" id="4905789at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI12064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="353" mass="41290" checksum="9586B65C9852D72F" modified="2018-11-07" version="1">MKLKYFLRVVFTLLLLFTRLRLLFQHTRMQRTDFFRHCPHRGLLTPLLDDDTKRDCDYRSWDVYEVEHMVAPNSKRLVIWHHKRVSAVVYHQFKALEGLGPGVTQGIFARTDFETKDVYLILAYKGTMKQRDREPFFQICKEVGREAVVGEPLEFRFADADKTMAELWARAKEAGIMGVNNRVEEYDRGLTFDELQDYLKRRPMTKNVKMASPGKYQALKADIGSPLNSKRFYSVLECDVKEDESGTNPWGEIILYNAHVTNVIFYNFPGLKASSADTHVVQGTRSTAEFMTQGSNGTITVVRRWGYIKEWCVEWFHETCEEVGKHVKVGDMDQLMRDLWDRVDEERILRNIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCC6</accession>
    <name>A0A367LCC6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Frequency clock protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_1265</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCL0</accession>
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    <organism evidence="4 5">
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        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
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                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
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        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="2" id="KW-0677">Repeat</keyword>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <sequence length="547" mass="59216" checksum="68D9BC9129E4C4C3" modified="2018-11-07" version="1">MPQKADKSSSAKTEKSDEKPPRSHTPGRLAGGSSKATNLAIRQRPQTTPLPSSSSPSTAAPAGPAPKEAPSSSSNTVAVEGDDEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDGDNEGHGKGKQPQMPSVTTACRTESLVPAPSSVPPPTSTPAPTLAPIPSSAPAPAPASRQTSTTTTRVTRPPRGSHVPFPPLQDPKDAPDVQPAPASGMYWSKAMTSGAPHHNLRAHTATIIGSNIYVFGGWDSRACFNNLYVLDADAFYWSVPHIVGEMPPPLRAMTCTAVGKKLVLFGGGDGPAYYNSIYVLDTLNFRWTRPRVVGDEAPCDGDKALNDIWRLDVSDVSKMSWRLIAHHHDDDDDDDDDNDNDNDDKAARDPPRPKARGYHSGNMCGSKLIIYGGSDGTKCFDDVWIYDVEKRVWKAVDIPVAFRRLSHTATLVGSYLFVLGGHDGDEYCNDLLLLNLVTMAWDKRKVYGKAPAARGYHAAVLHDGRVLMIGGFDGNVVYGDVTILELAMHAYYSQISHFTIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCL8</accession>
    <name>A0A367LCL8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_4612</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000008">
        <property type="protein sequence ID" value="RCI11972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCL8"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI11972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="115" mass="12903" checksum="53D2FE24E2384510" modified="2018-11-07" version="1">MTLHAASIGATIIATSSISLGTYCSPPPDCTTRSLRPLIPRTAIDSFPIRQTGEAVFLLAYCYQYQATYLRLLLSTNSTCSHILVFISATPRISMYYLPGSHTCYKNLRRYLPFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCW3</accession>
    <name>A0A367LCW3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCW3"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016663153" description="Secreted protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="76" mass="8428" checksum="03A9F8C4F09C9FA0" modified="2018-11-07" version="1" fragment="single">HSTFFVSSSFLSFFLSTSLAFTHIIICSYPFVNHAGYLYHGNDSETAATHGQRARLLNLSLIATPKVEKESISHIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LD15</accession>
    <name>A0A367LD15_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_0067</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LD15"/>
    <dbReference type="OrthoDB" id="5386330at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF41">
        <property type="entry name" value="SFGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="27"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="72"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI12319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="552" mass="60383" checksum="3BE05E833479AEDB" modified="2018-11-07" version="1">MVKSEPDAETAPLPPRQRKWHPRVFTGCVNCRRRHVKCDERTPSCTNCTRLSLSCNFDRRFVFKAVRPSSRPAAARRRKTASTSSNNEDEDDEDEADDDEHAVQLISSTSAAPAPSAAFVASPLALPTSTTADCRDALYYHHFLHTVSSYLIIYDTPANANPYRRLLPQLVGGGAGLLRDAMRALGAMHLSGLPGVPDRRVHRSTAVRTYASVVSRLRDAVSPPQGQADLEMLATSLLLCMLEQMSSADASWKIHLVGAGQIFHSLYSPRTGPSAAAAAGAGAGSSTPLLLPLRRFLVSTMSYLDVAAACATGGGPLIAGDYWETLGGGWEYNLGAPSLVRARSSASHRTMAQLRSSWSRVMSIQTDISRFAKLLRSGLDGRQSDMFRSDIAHRIRNWHDSVPDVFLRLDDEPVTMTTRRRDEDDEDVDALTAAACILSYALACTIYLERVSSRRVGSAVFDPTVKHAVDRILRLVGGFSSGVHRLAMLWALLTGGIATADAAQQSLLRQWLTEMKSFGFKHVSRVLDTLECAWQHGDYDELELTLSSNLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDE6</accession>
    <name>A0A367LDE6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_0981</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDE6"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI12437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="205" mass="22706" checksum="9ADD577B2F3C52DA" modified="2018-11-07" version="1" fragment="single">MSRRVEHNTSPALPSLRLSKMVPRAVQAIRVPKKTHPLEVDNVDDSILGHTHYIEVCCSHDASCLVKGPGTSRFMRRRPLHLPTNNTSSIITACGIYVSSTQDLHRSPSCFPISTTGHELLWLAINVVVVLTLCINVRPFRLTSLGRSIVRAGSSTSLVRAPSREARRSKYPEHRLLGVLSSWDAIVLFLAKAELHWTMGQAVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDF7</accession>
    <name>A0A367LDF7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PRISE-like Rossmann-fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDF7"/>
    <dbReference type="STRING" id="1330021.A0A367LDF7"/>
    <dbReference type="OrthoDB" id="1731983at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055222">
        <property type="entry name" value="PRISE-like_Rossmann-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487">
        <property type="entry name" value="3-OXO-DELTA(4,5)-STEROID 5-BETA-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487:SF4">
        <property type="entry name" value="SIRQ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22917">
        <property type="entry name" value="PRISE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRISE-like Rossmann-fold" evidence="1">
        <location>
            <begin position="7"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="408" mass="44520" checksum="D21C67453AA38C3D" modified="2018-11-07" version="1">MADENHALVFGATGLLGWGVLEQLLSDEGTFTTVTAVLRRPTTAEELGLDSVSDKLTLADGVDLLADDDVGGRLLERVSGVERTTHVFYFGEFDGSAGDLETETDGSKAFAAVDGEHREVEVNADMMRRVVAALNVVAPRLRSFVYGGGTKQYGIYAPGGTWPAPLQESLAEGEQQSMQVSPWCVYPVQRRMLAESSRGRAWSWTEICPDAVIGFTPFGSAYSLALHWGQYLSLYAREKGAGHGVPFPGSVEGYDSRFTPVSTRTLGRVAIFVGLLHLDDGGGGVDGKMINVADREDAVSFRKLWPEIVAWFDLVGVGPPESASTTTKKPGEYVHLHRALFKQAGKPRAVSCGVGAGGRQLDEVGWWLTFDRHMSLRRLRRLGFGEERDVVDGWVEAFERMREAGIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDU8</accession>
    <name>A0A367LDU8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L249_0104</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDU8"/>
    <dbReference type="STRING" id="1330021.A0A367LDU8"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000036">
        <property type="entry name" value="Vacuolar aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000002">
        <property type="entry name" value="Vacuolar aspartic proteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017066249" description="Peptidase A1 domain-containing protein" evidence="13">
        <location>
            <begin position="18"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="14">
        <location>
            <begin position="97"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="128"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCI12586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="407" mass="44317" checksum="186D2FEDBB7CFAC7" modified="2018-11-07" version="1">MKSSLVVAAAFAACAQAGVFKTKLQKISLEQQLADSSIANQVESLRNKYEGLRQQSWAQKALGARPKTHVETMFDSSPVFVDGLHPVPVTNFMNAQYFTEITIGTPPQKFKVVLDTGSSNLWVPSSQCSSIACFLHSKYDSSSSSTFKKNGSNFEIRYGSGSLSGFVSRDSMSIGDIKIDDQLFAEATSEPGLAFAFGRFDGILGLGYDTISVNHIVPPFYSMVSQKLIDHPVFAFYLSSTDEGSEAVFGGVDKNHYQGELKYIPLRRKAYWEVDLTSLAFGKEVAEMEDTGVILDTGTSLNVLPSSIAEMLNAEIGAKKSWNGQYTVDCAKREKLPDVTFSLAGLNYSLPATDYILEVSGTCISTFQGMDIPKPAGPLAILGDAFLRRYYSVYDLEKGAVGLARAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEG3</accession>
    <name>A0A367LEG3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEG3"/>
    <dbReference type="STRING" id="1330021.A0A367LEG3"/>
    <dbReference type="OrthoDB" id="4922598at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="440" mass="49171" checksum="B376D12FCBFE3274" modified="2018-11-07" version="1">MPFRKWLQSTLGLSRDGATEQQPGIMTSWTASTHGNYSRHYYAPTDRQRPTVARSESVPGDGSVRLDGTRSQVGHQSVFQQRRENEQNARPTKEKQDPSAPPLLLQVMDRESIIEVASLLARLFPHHHLAICDHAAMALHGQSNLQPNYVSILCPTDEADDLLSKAQARGLRRCHLYPRAFYLMTSRDGVVVARCVRILTCRRFRCLDGVEKLLGPFCAPVLSLACVADRVARDYRRCLDNEPCHEVAVRRGADLIWLIANITHQSSSSPQDFLDSFTRRFPETILLLREAGFDIRHTHDGQQPSSKRRSRDGIVIPPSYLGKRNTAALLKRTMTLVHAATRFRLQGERARAASPPPPPSSSAKLWPAPLRLRPRPASCYGPTAPPEIPPRSRARLSLARSEDAGVRASLKSMELVIGKDIVLCRDWPPEHPPTGGQRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEP0</accession>
    <name>A0A367LEP0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEP0"/>
    <dbReference type="STRING" id="1330021.A0A367LEP0"/>
    <dbReference type="OrthoDB" id="66095at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="320" mass="36136" checksum="55C1F5A5FC69F928" modified="2018-11-07" version="1">MPRPFTPSLPNGVGTSANPDFEPLPGDIAFTRATLMRSRRLPPDIIDLIFDHAEYWAHSSSVVEQSLRISGSGAVENKFLIRCPPLGITKVARLAEELAYDTTEAQPLPLVEEHGPVFFAGLVDYPTPRIIYPCRKIVFSIRSRDQGWGNVNAEDTDPYSSSYTWFEAGLERFDASQECTSPCDTHCTYDVRREVSTETAPHLPICGLRSIYPATRMDSDSRRSYRHPLLPDDYFNIQRNRAAFGQWQDHRVVWAYDDDIDPTSNLGMELQRCGRGRASGIGGFVRSLKLGDVVTVWGKARFPMWVNMVEAVRVDIYWAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LES4</accession>
    <name>A0A367LES4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_0588</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LES4"/>
    <dbReference type="OrthoDB" id="3550095at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596:SF2">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G17550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="455"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="490"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="585"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="490"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="524"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="675"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="787"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="802"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="819"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="843"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="886"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="917"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="947"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="974"/>
            <end position="984"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI12925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="984" mass="107227" checksum="6D2542C18A088532" modified="2018-11-07" version="1">MDQMRSLILSGDKPVITLHELPGQRLPVLELHNGSDFPYVAISHVWADGLGSTAEKGLPVCQLRRLTSLVSETKPGTALWIDALCIPEAAEARNLAITMMASIYKDATAVLVLDSGLQSCRSDEHLGTKLLRTLTCGWMRRLWTLQEATLSRELHLVLADGPWPLKALIPLYGDLYYRRPLLDLAKQLFPLIKRSAYGSCCLGDVARALTWRNTSKRSDETLAIAGLLGVQPSTLTAIRPEGRIMRLMQAIGRVPRNVLFLGGKKLQLPGFSWAPMSFMAAHGGAAEGTELSVSDTDAVVTPRGLAATYFAFILPSKVPKEMNCWRLRDTKTGKLYSIAGGESDSTEPISYDLLLTMNDTDNLRGCIISAFASPPGCDASHAICRRLGRRVCGLASRQLLVFLAFLVASPSLLLSILASTVHRGFESCEDTEPQHASHTLEMTDSLRGRQAQEARCYNCGSHGHWAVACPEPTRKTPAGLAAWRNASAGNVKNQSYNPGSRRSKGPIITKYSPPSFASNMGSSYPPPPPPPPPGGHPPTGLHLAHPYTHAFQQGYPQPALSYHSSPQFTPSATYGLPHYGQPAHLGLPSPLPGPPAGSCSNLDYGPPRPPYHASFPRSAPSQKPPHNKSAPRNARKSELPFSIAKPPMTRLSHPLPPKPPPSHDQMQPQRDVRNRGKINRHHNQGKGPRSARSSDFEAPVSHDSLAADRSLPGNSPASGRHGDGNAYARRPSQSPGKGIHECEANNVRATSVTRAEDKLNGDVAGKSVESLESAITGKGVSAWSVDEPDRSDFAMGREKSLSLRSNDTGDTAVSCTVEASDEHEDGEISSDEDVRSPTPHDGATAEEKSNSPAVEDHWRPKRRYSDEWDEDVSYAKRLKPTGASRIGDKFKEDGHVDDDLWDSLDVPRQADRKRRGSAGSRHSSVSSKSSDLNSLEAELLGRPVKQRPVEEASPRPRSRSERRPVSKPKKRRQNNTNSAYSRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LF20</accession>
    <name>A0A367LF20_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_1097</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LF20"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000013">
        <property type="entry name" value="Related to multidrug resistance proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF84">
        <property type="entry name" value="VACUOLAR MEMBRANE AMINO ACID UPTAKE TRANSPORTER FNX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="526"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="67"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI13016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="558" mass="59838" checksum="6B8147FAF9519480" modified="2018-11-07" version="1">MSRDGNMSASERTPLLGKTGFVSQTASLSSVENGIENDGIIADNDGDACPAAAKQGNPEMAKKMHLLLPAVGIGIYLVAIDQLLAVAMYTKIGSDLNALNTTSWVATSCVDPKNLYFLTLTSFQPLYGKLSDIFGRRECLLFAYAVFGLGCLGCGLAQDVTQLCIFRAISGIGGGGMNSVVAILMTDIVPLRDRGVWQGYLNIIFAAGTSTGAPLGGLLADSLGWRWSFLVQTPLCIVAWIAVYCVLDAPSTSRDKWLAKLRQIDFAGAFVLVLAVVALLVGLDSGSNLGWSHAFTIVSLALSVPFFIIFVLVESRFATHPFAPGRVIFHRGLFACYLANFLGSAGYFGAIFFLPLYIQAVEGCSATVSGVLLVPAMICNVVMSLLGGWVIKTTGRFYWITVAGFGVMLLSMLPLMLSTWLRFLPGALLGLVLSAGLTTTLVGLLANAAIEDSAVVVACSYLFRSLGASIGIGTSSAVMQHVLRSQLVARLSSGDEARWIERRVRENIDIIKQLPPREADLVKLSYQYATLGAFTPTLVFLTICFVVTFWVKEKPLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LF37</accession>
    <name>A0A367LF37_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carboxymuconolactone decarboxylase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LF37"/>
    <dbReference type="OrthoDB" id="9998495at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003779">
        <property type="entry name" value="CMD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34846">
        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34846:SF11">
        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02627">
        <property type="entry name" value="CMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxymuconolactone decarboxylase-like" evidence="1">
        <location>
            <begin position="44"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="193" mass="21148" checksum="161348798448C9B2" modified="2018-11-07" version="1">MRLPYVDNPPPPTTAEDAAIVQRIAARRAPRPLQPLDLTLLHAPAVADGWNSFLGAVRTGTSLADDIRELAICRVAVCNGAWYEWHHHAPLAVRAGVVEAALDAVRSSGPLEAVTRPKELDEGQWAVLLYTDEMTRYVRVKDDTFTLVHRLFCDRQVVELTATIAAYNCVSRFLVALDVGERNAPGPGEASLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFN0</accession>
    <name>A0A367LFN0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription initiation factor TFIID subunit 1 histone acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_0695</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFN0"/>
    <dbReference type="STRING" id="1330021.A0A367LFN0"/>
    <dbReference type="OrthoDB" id="5752at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040240">
        <property type="entry name" value="TAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022591">
        <property type="entry name" value="TAF1_HAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12157">
        <property type="entry name" value="DUF3591"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 1 histone acetyltransferase" evidence="5">
        <location>
            <begin position="405"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="220"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="303"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="536"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="745"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1097"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1170"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="231"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="312"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="761"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1097"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="1125"/>
            <end position="1139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI13062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1208" mass="133345" checksum="E709F2537ACDF414" modified="2018-11-07" version="1">MAEAKFSSLDENEWKAQDAADEREIARLLEQSQEGANGGLTLDDTPFDQTNKADDAQDFEDISDDDLPEEEEGPSAGNAAEMPGLTDDGGTSNDADDLFGEGPSSPIDPVPGPASPAPQVREDADTQAADASLSFASINFDPDPHLHGAANQDPDIPSAAETVEDLLRAAWPAFDRGRILTWSELLPPKRSVWKEKKPVKRPKRLVTSKLTLDLAPDKEKQFRIPGPAKGRTGGDSYQGGGLVLCGPPDEDEDKDVERIDPDVDSDSETVNGFTLRDIEMVCEDWGARIEAAEAEFLAAERELQSRKRPVEDEQDDEWDAEFLDADDDPQPRAKKRRRVEFGLPEIPRWTAPSFDNFEEVTRLGAKRVVLDLSDPRLLIETEPTNQPPAKRTALGRAGRDLSQRFNLSNDESYELLKENHQSKVRATLGNISVEHSMPAIKLTWPYYKVKLTGTTDEYHRPRFRYKKFAGHSIKFEKPLHHKRKNMRGKAYEVFVRSKDLCMCDNAAAVLFEYCEPRPRVLSNFGMGNKLIHYFRRKDDKDEEQQPPPPKPELGEHRMLLPEDRSPFSLFGTVDEGETVPTLHNEMFRAPVFRHAPRATDFLVVRSTTGVEGSRWFLHKIDHLFVAGQTFPSVEVPGPHSRKVTNASKNRMKMLAFRLIRHSAGDNCQLSDITKHIADSTDTQNRQKLKEFLQYDRDSGEKGMWRLKPGEMLPDENAVRTMIKPEDVSLLDAMQLGIKELEDAGYDPRNANIDDDQVADVDGGGGGGGGGGDDDEMDDDGGSKLTKGGNKKAAEKQEETLADKMAPWKTTKAFIDACAQKAMLQLHGEGDPTGHGLGFSFIRTSMKGGYIEAVQGPLATSADAMEREKRANGGHAYNVKRQQAMYEEGIREIWEKQRTTLSDGQEHDDGDVAMTEDEDDRFNVNAAATPAQFDEGVSQISGLTSSSRHPKRAIRITREVQTLDGSTQTRTEVVHDPVVISQYMKRRTEADLELREYVEHTLRFPNSARSPPPIWKRLPTGVRRVLRWTAFRGRETPGGPRVAAGSVADGVGLEFRLPAYVYLSTASTARVLRAMPTMTVLQTLADRIKKELERLEKNKARRQAREQQKELHQKAHVGDAGSPGPNTGGGGGGGGGGGGDKLSTGTTRKCANCGQVGHIKTNKKLCPLLNGTMKTDGGTAEHGGFGNYKSRTGTAGSPAGEGGSRVESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFP8</accession>
    <name>A0A367LFP8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_0129</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFP8"/>
    <dbReference type="STRING" id="1330021.A0A367LFP8"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05808">
        <property type="entry name" value="Podoplanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016653968" description="WSC domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="4">
        <location>
            <begin position="54"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI13245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="310" mass="32614" checksum="0167A38CF4F4925C" modified="2018-11-07" version="1">MKTFTIALAALAAASQAGASLDRPTIVQRNLQGTLVERQATSLQKPSTFPLPNALTPHGCYKSKGNMTTRDVDHLSSGSCSDACKSGKFWVSGMQGTQCYCGFAYPPQKDLADDAKCSYPCPGYPYEACGALADSGGFWSIFNTGINVNVKNVEDSSTTTSSSSQSTNSKSDDQEPTGPSVVTQTHVTTQGSNTDDKKGGANTVGIAAGVVAGVVVAAAVAGGLIFFLRRKRNAQIEEEHRRNAAVSAFINGSKPPGSSGSMSMTDARLDPVMANRRMSDGSIADNEDYSRRILRPALIVNDEPLQVTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFR1</accession>
    <name>A0A367LFR1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1197</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFR1"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="132" mass="14588" checksum="58B9A26B2FD8BFEB" modified="2018-11-07" version="1">MGEKRGRQRNNKGESSPVDYESRTLGCSSVSLPTSSTSITTSIHVHDGLRWHGGETDGKKKRRRGRGERVGESEDEPDGVGLNPWFLSCFAKGAFALGGFLLAMSWEEEVQYRQPHRKGKRMPSGVLTVVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFU2</accession>
    <name>A0A367LFU2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">OBG-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_1031</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFU2"/>
    <dbReference type="STRING" id="1330021.A0A367LFU2"/>
    <dbReference type="OrthoDB" id="545683at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04938">
        <property type="entry name" value="TGS_Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01899">
        <property type="entry name" value="Ygr210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.470:FF:000001">
        <property type="entry name" value="GTP-binding protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013646">
        <property type="entry name" value="YGR210-like_G4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF1">
        <property type="entry name" value="OBG-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08438">
        <property type="entry name" value="YGR210-like_G4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="4">
        <location>
            <begin position="5"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="11"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI13304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="427" mass="46046" checksum="14DED4DCA29545DF" modified="2018-11-07" version="1">MPRDPLIGLVGKPSAGKSTTLNSLTDASSKVGPSPPPTIRLRDFCFTTIDPQRAVGYLQIDCACARFDLSDRCRPNHGSCVAGRRSVPIELLDVAGLVPGAHEGRGLGNRFLDDLRHADALIHVVDASGTVDAEGKPTRGYDPSVDIAWLRAEIVAWILGNLMQRWPSIRRRHIAVKAAALDTLVAQFSGYGADAGLIGRALDRAAVREPLESWDDGTIRHVVDSFVDEKFPTVVALNKIDHPDADKNIAKIAKAHDPASIVLCSAISETFLRKMAKQGYIRYVEGSDVVDTKEDLIEEGDPDGGGLKELDDKNRTRIENLKDMVLFRFGSTGVVQLLTRAADLLGLVPVFPVRNTTTFGSGASDSRFVFRDCVLVNKGSTVADVARKVMGDAPIAYIEGVGNLRVAENDAVAVGKNDILSFKVGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFY8</accession>
    <name>A0A367LFY8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA primase large subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_1208</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="9">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic-type primase large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFY8"/>
    <dbReference type="STRING" id="1330021.A0A367LFY8"/>
    <dbReference type="OrthoDB" id="421393at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07322">
        <property type="entry name" value="PriL_PriS_Eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.80:FF:000003">
        <property type="entry name" value="DNA primase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058560">
        <property type="entry name" value="DNA_primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016558">
        <property type="entry name" value="DNA_primase_lsu_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007238">
        <property type="entry name" value="DNA_primase_lsu_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537:SF3">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04104">
        <property type="entry name" value="DNA_primase_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26466">
        <property type="entry name" value="DNA_primase_lrg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009449">
        <property type="entry name" value="DNA_primase_large_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7 9 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 9" id="KW-0639">Primosome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA primase large subunit C-terminal" evidence="12">
        <location>
            <begin position="303"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR009449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR009449-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI13343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="506" mass="58323" checksum="7CB22F5DA9310405" modified="2018-11-07" version="1">MLRHDRHRIDPKRRHVTDHRKTQFAKPQYKDAEYPHRLNFYSEPPTADITLEQFEQWAIDRLRVLAELEACSFRNKTPAETATHMQPMLEKLLPLSANSSGSSKLFAQRQKDHYSHFILRLAFASTEDLRRRFVRAESMLFRLRFNGDDLRERTAFVSSLDLDWRESVTEEEKRVFASELAALAGPPKRGGKGRGAEDETWLKVGWERVPDLVEQRRVFVKAGKAFVPGKEVSSMIVAEFSTRLQRQLELTARALPRLDEDDRLTPILQHLSKNFTTPDSTYASSTAPEGAEMTAANVDRLSQQFPACMSNLHRSLRRDAHLKHYGRLQYTLFLKGMGLNLDECLLFWRNSFHKINDDTFNKEYRYNVRHAYGDVGGDGNRRGGGYSPFSCQKILTEHPPGPGEAHGCPYRHFSMENLTTLLQDMGVTDRSVLQGVKEDKKGQKFHMACNRVFEHVHKAEMKRAKDEGIMTANQLETIIHPNEYFKRSYLLKNLDRAGGGEVKREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LG09</accession>
    <name>A0A367LG09_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_0793</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LG09"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI13351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="207" mass="23424" checksum="DD24F0AE5744F085" modified="2018-11-07" version="1">MKDWFFEMNEEEKKKKKKKKKKRRPSYHSSSSPQVSLASFIQRILPGSCNSVFLTPVSGNSRHAWPTSMQDDKPSVRPPRKWRPSVLSERVSLGPVPVLKEIGLHARLIIGLQCRGGLKAVFFFWSTGDVSDPTSFLPAKTLLNITCKLRIKKTISLERRERDPSGLLEEDDDDDLRRSDPFIFFLASAPPKIVVAIVIVIVIIIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGU4</accession>
    <name>A0A367LGU4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein PBDC1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_5554</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PBDC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGU4"/>
    <dbReference type="STRING" id="1330021.A0A367LGU4"/>
    <dbReference type="OrthoDB" id="10248897at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3560.10:FF:000001">
        <property type="entry name" value="Protein PBDC1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3560.10">
        <property type="entry name" value="yst0336 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023139">
        <property type="entry name" value="PBDC1-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008476">
        <property type="entry name" value="PBDC1_metazoa/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021148">
        <property type="entry name" value="Polysacc_synth_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410">
        <property type="entry name" value="PROTEIN PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410:SF9">
        <property type="entry name" value="PROTEIN PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04669">
        <property type="entry name" value="PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polysaccharide biosynthesis" evidence="5">
        <location>
            <begin position="27"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00061201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00069779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI13631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="161" mass="18647" checksum="6A7DA6E25DDAD2C0" modified="2018-11-07" version="1">MDPIHQLSGAAVPAGFDAAQAINMEEMEQQFAVKAVQQMQTYWSLLETVKGSTLRLTKMDDDIYAHLTEAFPDFDPAATIDEDEMKSKTGKERWRTFMMTYEKKIDEYNFGTMVRDSPKVEYEEKTTIFVPRMQFYAIEIARNKKGLNDWIHDKAQADKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHS7</accession>
    <name>A0A367LHS7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_8023</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SH3BGR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHS7"/>
    <dbReference type="STRING" id="1330021.A0A367LHS7"/>
    <dbReference type="OrthoDB" id="9932926at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006993">
        <property type="entry name" value="Glut_rich_SH3-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051033">
        <property type="entry name" value="SH3BGR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12232">
        <property type="entry name" value="SH3 DOMAIN-BINDING GLUTAMIC ACID-RICH-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12232:SF0">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04908">
        <property type="entry name" value="SH3BGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI13802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="265" mass="27923" checksum="78DC0F7B7C77EA62" modified="2018-11-07" version="1" fragment="single">LFIFTSLTAGSSHIVTATSRLETILRANRVPFKAVDVATDEKARTLWGRRAGKDSSGRPRKLPGLVQEGLVLGDLVEIEDWNEYGELKQHVKIYYDEHTIPSIHDKPKQPQRKQQPKSQQKPPAPPAAPPESVPAPSSASSSSATAAASSSLPVRSVADEAAQKAKALRTKALREKVHGKDPAPGSEAAVGESSGPLQCPSTAAWPPSREDAPQSPTSSCWPGDALEYEHKKAASGVPAAPVPLEDDVVSGHDGGGATKETAVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHT0</accession>
    <name>A0A367LHT0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_8045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHT0"/>
    <dbReference type="STRING" id="1330021.A0A367LHT0"/>
    <dbReference type="OrthoDB" id="342454at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46620">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN SPF31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46620:SF1">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN SPF31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="39"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI13993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="217" mass="25712" checksum="E65D52A2347E5140" modified="2018-11-07" version="1">MASKEAVEDREALDALEVEVKEFDKDAEIERILKAFRLDSYAVLDLQPGVTESDIKAIYRKKSLLIHPDKTKNPQAPEAFDRLKKAQTELMDEKKRAILDEAIADARMLLLRENKWTPDSPEIKTEEFASMWRDKAKYVLIDNEHRRRRQIKGQMQEEGREQRKADAELEERKRKRQHDQDWEATREQRIDSWRSFQQRAKADPEKKSKKQKLKPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHT8</accession>
    <name>A0A367LHT8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI14003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHT8"/>
    <dbReference type="STRING" id="1330021.A0A367LHT8"/>
    <dbReference type="OrthoDB" id="4927564at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="466" mass="50011" checksum="E60458EF63C9B840" modified="2018-11-07" version="1" fragment="single">MYLLFTREEVPTSTFHALRSPSPPPQKNSSLTEGQKHPLIFFHPISSIRLDHLPRIRIMATASGFGDHDKLAAAKELAQSFKPAKAKGYRPVQNVPKRPTMSFEAEGSCQTLGASVPQPSQRHYVGLGKFGAPTQKMNQKQLVGKSGLEFLRRVDNTEDPVAAEVEETMAAKDSGKTAAIRASPPAATATTTPLEPKGESLVIQAKPKNIAKGSLLETFYAVVEDSESSSNVASPAEMKQETLIDFDDGAGGVDVLASTIPKTLTLLVPTPAASTPSPIVDVSEVKPQKVVDEKPSVHVSDEKPKAGHLAQSIHAKKSTLCPKASNFTPKQRVESPVRQPESVVEVEAEAAAQPIHRRNTSVEIVPARTEISAPATLSTSAQVYQTIIPVPLLISVLPVTAAYQPTPSTTCQRDETSTQPLRPVEVNGGLKASRWASRRRSKMFAAAGVHLRQLKSVLYPAASACL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIG1</accession>
    <name>A0A367LIG1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_6079</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIG1"/>
    <dbReference type="STRING" id="1330021.A0A367LIG1"/>
    <dbReference type="OrthoDB" id="364348at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000059">
        <property type="entry name" value="Related to syntaxin 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF38">
        <property type="entry name" value="LD27581P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14523">
        <property type="entry name" value="Syntaxin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00503">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="4">
        <location>
            <begin position="174"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI14167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="268" mass="29980" checksum="F9449EBC909DD2F4" modified="2018-11-07" version="1">MSYEQLSSLESGRRDGGSGGYSDDPAFRDLQHALKSKLQSLLSGNRKLANDVNVLGTKKDTPRLRERVHNSMEKTRELCRDIGDGVKQLQAWDDLSKQQRYEQTKVSSDFQAALQEFQSLQRTALEKEKASVTAARAAHESESGPSGGTSFEQQQQQQQLLSQMAPQDEVDFQEALIIEREEEIRNIEQGVGDLNVLFRQVAQIVDEQEVGIRTIADNVENVHDNTRQADVETRQAARYQKAARNKSCCLLLILAVILTIVILAIVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIU3</accession>
    <name>A0A367LIU3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA (guanine(10)-N(2))-methyltransferase</fullName>
            <ecNumber evidence="9">2.1.1.214</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_5956</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM11 methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.214" evidence="9"/>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIU3"/>
    <dbReference type="STRING" id="1330021.A0A367LIU3"/>
    <dbReference type="OrthoDB" id="296065at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160102">
        <property type="term" value="F:tRNA (guanine(10)-N2)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RlmKL-like_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016691">
        <property type="entry name" value="TRMT11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059073">
        <property type="entry name" value="TRMT11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370">
        <property type="entry name" value="RNA METHYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370:SF3">
        <property type="entry name" value="TRNA (GUANINE(10)-N2)-METHYLTRANSFERASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25904">
        <property type="entry name" value="Tmrp11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017259">
        <property type="entry name" value="tRNA_mtfrase_TRM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51627">
        <property type="entry name" value="SAM_MT_TRM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 10" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 10" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="tRNA (guanine(10)-N(2))-methyltransferase TRMT11 N-terminal" evidence="12">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA large subunit methyltransferase K/L-like methyltransferase" evidence="11">
        <location>
            <begin position="182"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00066937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI14363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="396" mass="44322" checksum="13886007DAD9E8E9" modified="2018-11-07" version="1">MDFLIKFAQTHETFRLAEIEALADVEGVDMTVVEYSLKSPLCLVRLPSVEAAQKLIRRSILAQSIHELWGFGHNLDVLHQSVQERTRHHWPQYASPSFKFVFESFQGARSDSRKLAIINSFDYLPFDGPIRMSRPDEVFTIFETWPYNSPVLGIENPDMMYFGRFIADSSRGVVLRFDLKKRGYISTTSMDSELSLVTANIALAAPGRLFYDPFVGTGSFPIACAHFGAVAWGSDIDGRIIRGAGGHNSARGNFEQYGLTDGLGDFFSADLTNTPIRDARRIWDGIVCDPPYGVREGLRVLGIRDPEKTPKLVEQGIKKAGRPDFVPPKKPYSFMAMLDDILVFAAATLVDHGRLSFWMPTANDEDQEIPTPSHPRLELVVVCVQPFNKCEKGLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJ70</accession>
    <name>A0A367LJ70_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L249_6120</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VTI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJ70"/>
    <dbReference type="STRING" id="1330021.A0A367LJ70"/>
    <dbReference type="OrthoDB" id="430637at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01736">
        <property type="entry name" value="LSm14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15862">
        <property type="entry name" value="SNARE_Vti1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000002">
        <property type="entry name" value="Vesicle transport through interaction with t-SNAREsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.400">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025762">
        <property type="entry name" value="DFDF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019050">
        <property type="entry name" value="FDF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025761">
        <property type="entry name" value="FFD_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025609">
        <property type="entry name" value="Lsm14-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025768">
        <property type="entry name" value="TFG_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038407">
        <property type="entry name" value="v-SNARE_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007705">
        <property type="entry name" value="Vesicle_trsprt_v-SNARE_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586">
        <property type="entry name" value="SCD6 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586:SF0">
        <property type="entry name" value="TRAILER HITCH, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09532">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12701">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05008">
        <property type="entry name" value="V-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01199">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01271">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51512">
        <property type="entry name" value="DFDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51513">
        <property type="entry name" value="FFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51536">
        <property type="entry name" value="TFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="DFDF" evidence="14">
        <location>
            <begin position="598"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="FFD box profile" evidence="15">
        <location>
            <begin position="656"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="TFG box profile" evidence="16">
        <location>
            <begin position="684"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="288"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="582"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="627"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="669"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="47"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="FFD box" evidence="9">
        <location>
            <begin position="656"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="TFG box" evidence="10">
        <location>
            <begin position="684"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="346"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="434"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="684"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="710"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="723"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="736"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCI14459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="746" mass="79350" checksum="316C9E32821329C2" modified="2018-11-07" version="1">MANPLDTDVGSELFGSYEAELKLVQADLSQKLDQIPELSGEPRKSSISQAERALEEADELLGQMRLEKQNIPTASRAKANQRFRNYEADVDASRRKLTSLSSDRSALFGSRYRDEPAGASDAHLEQRQQLLSGTDRLDRSTQRLKASQALASETEAIGADTLANLHGQREMIQHTHDRLLSSEGYVDRSVKTLRGMARRMATNRLITVAIITVLVILILAVIISKFSYVGTLHEINSDESTVSLENVRSFGTEGRRGRVEDEIAPSDQVYEYIVFRGSDVKDLRIEEHPSVKENKPPPAMPDDPAIVGARPRDSAPGQPGPPAAGNFQHPYPPNNFYGGPPPPGSWGRGGGAGPMPGPGSGFGMPYPPPPHWFPAGQGFPPGGPAPWGSHLPPPTSGAPSGAEAPNQYQPPPPGRPQDGKTGLAGPDQDRLGSATPSFKASQADSKPPTQPSRQPSKAPSPPIESKPSVEEVKAAATNLSGSGTFPDAVDSPKPSIPNAPRNNRITPVVPLSGPSAKPFALPSSGKTGQVTVKANVAAGPSSVEDATNAARAAVAAAMAQLGGGGNAMDNLTNKVNEMRVNAGRGVTVGRGRGRGGRQATQKVEVPDSDFDFQQSNAKFNRQEIAKEAIAGSPVPENPAEITTSSEAEVMNGNPAIAYNKSKSFFDNISSEAKDRAENNGQKPGGREWRGEEQRKNMETFGQGSVDGGYRHYRGRGRGRGNRGRGYGRGGNRGGNWPQSQPAAADW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJP4</accession>
    <name>A0A367LJP4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Acyl-coenzyme A diphosphatase SCS3</fullName>
            <ecNumber evidence="6">3.6.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">FIT family protein SCS3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">SCS3</name>
        <name evidence="6" type="synonym">FIT2B</name>
        <name evidence="11" type="ORF">L249_6562</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate. Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates in the endoplasmic reticulum (ER) lumen. This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis. May directly bind to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis. May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation. May play a role in the regulation of cell morphology and cytoskeletal organization. Involved in phospholipid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(5Z,8Z,11Z,14Z)-eicosatetraenoyl-CoA + H2O = S-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:65568"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57368"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:156554"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(9Z)-octadecenoyl-CoA + H2O = S-(9Z-octadecenoyl)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:65564"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:156553"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an acyl-CoA + H2O = an acyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:50044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:132023"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>hexadecanoyl-CoA + H2O = S-hexadecanoyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:50032"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="ChEBI" id="CHEBI:132018"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Endoplasmic reticulum membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the FIT family. Fungal FIT2B/SCS3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.-" evidence="6"/>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJP4"/>
    <dbReference type="STRING" id="1330021.A0A367LJP4"/>
    <dbReference type="OrthoDB" id="5579088at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003877">
        <property type="term" value="F:ATP:ADP adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03231">
        <property type="entry name" value="SCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009163">
        <property type="entry name" value="Ap4A_phos1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043171">
        <property type="entry name" value="Ap4A_phos1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045759">
        <property type="entry name" value="Ap4A_phos1/2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019200">
        <property type="entry name" value="ATP_adenylylTrfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019388">
        <property type="entry name" value="FIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046400">
        <property type="entry name" value="SCS3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420:SF3">
        <property type="entry name" value="5',5'''-P-1,P-4-TETRAPHOSPHATE PHOSPHORYLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38420">
        <property type="entry name" value="AP-4-A PHOSPHORYLASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19327">
        <property type="entry name" value="Ap4A_phos_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09830">
        <property type="entry name" value="ATP_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10261">
        <property type="entry name" value="FIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="Ap4A phosphorylase 1/2 N-terminal" evidence="10">
        <location>
            <begin position="322"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="ATP adenylyltransferase C-terminal" evidence="9">
        <location>
            <begin position="505"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="195"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF19327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI14597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="623" mass="66857" checksum="0AEA1F687604B46B" modified="2018-11-07" version="1">MATTTTTHSSRSDPAPPRNSPYLPTPLERLAVSVYPLILVFGAIFSLVSPETRAAPYDVGAQSHEQSSAPSYFARKSNVFNVVFVKRGWGWTTFAFVFFLFAGGLESSSSPSSSAVVDRVRVQAFLRWCCATAWWVCVTQWCFGPALIDRGFRWSGGRCEGGGEEAGGDDFMHITAVACRAAGGRWNGGHDISGHVFLLVLGSWFLAQEVAWPVMRAAAARRRRMRMRGGAATTTTTTMTDDRCVFMPDGAVKGVGVEVEASFGVAAKVALGVVAMKLWMLLMTAIYFHTWFEKFTGLATALAGAYGLYIVPRFVPGAIKIPTNLPETVKTIFAKAKSDGALTFYPTQAAIVKVGAIPFQLRFSPSLVKKPEPKRSSATSSAAVDPFANPPPSLYVAGVGKAHYLVLNKFAIVAEHLILATNDFESQTELLGLRDVEATLACLRAYGGGLFAFFNSGVHSGASQPHRHVQLLPIEGMRQGLVPASADDEARWEPLMGRQDLLDGAPFVSFAEDMDDASSAAHVHAAYLRLYRRACRALGVDGAEEQVDGEARVSYNLALTDGRIVVCPRRAEGEGDVAVNGALLAGTALVKGEDVWRALVAEPGRLGEVLGRVGVARGGITRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJQ7</accession>
    <name>A0A367LJQ7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DOMON domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_6780</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJQ7"/>
    <dbReference type="STRING" id="1330021.A0A367LJQ7"/>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09630">
        <property type="entry name" value="CDH_like_cytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019711">
        <property type="entry name" value="ATP_synth_F0_suH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015920">
        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005018">
        <property type="entry name" value="DOMON_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF4">
        <property type="entry name" value="DOMON DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10775">
        <property type="entry name" value="ATP_sub_h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16010">
        <property type="entry name" value="CDH-cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00664">
        <property type="entry name" value="DoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50836">
        <property type="entry name" value="DOMON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017041174" description="DOMON domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="DOMON" evidence="4">
        <location>
            <begin position="29"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="461"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI14666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="502" mass="53857" checksum="741D51474C187E5B" modified="2018-11-07" version="1">MRLTNKAAAAVALSATTASAATGPFCPESGVCFRWAVPSNSTTTTSNDVMFQLQAPTSYRWVALGIGSQMRDADMFVVYASGSNNNVTLSTRRGTGHQPPRYTERSDVQLVEGSGISDGIMTANVRCSGCDSLDLGGSSEWIAAWQSGDAINSQSPSAPIAKHDGFNSFSVNMATAAGSTNRAPFFGSDGPSGANPVGRPRGPRLGLAHGVLMSVIFIFGYPVGSLLMPLVGNWLLHGIWQIVTFLGMWAGFGIGYYIAQRRGILYAGPHTTLGTCVCALMCLQPVLGYLHHMYYVKHRTRGPVSYAHIFYGRSLMILGLVNGGLGISLTGSDRTFVIAYSVLAIFFFLLYVGVSVVFSVRKMKQAPAHKPSSVIHYCHYSAWGRDFGAEDVHGADDFSKADFVQELYLKELKAYKVPPVKESDSHGQVQAFTMPKTPASPEETDLASSLKQYESMVVDIQAGRQDLSSDPSSSSSAAAAATPASLPDWLEVDEEDESPRAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJS2</accession>
    <name>A0A367LJS2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">L249_6959</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the U5 snRNP complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJS2"/>
    <dbReference type="STRING" id="1330021.A0A367LJS2"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17945">
        <property type="entry name" value="DEADc_DDX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000322">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057479">
        <property type="entry name" value="PRP28/DDX23-like_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25430">
        <property type="entry name" value="DDX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="18">
        <location>
            <begin position="274"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="305"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="519"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="13"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="674"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="13">
        <location>
            <begin position="274"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="26"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="76"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="674"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="701"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="730"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RCI14649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="750" mass="82304" checksum="BC4E586EF79ABDD0" modified="2018-11-07" version="1">MPLDIEQILKKRQEAETAAAKPRFIPRAERNRLAAEQFQKQEDDKQRKAAAEVRRRREEERKWRDRARMPPPPPSGLNGSSSSSAAVPTGPRAMNQNRGKKGAEKAMGDKRSAEEIEATLLRSRYLGPEVNQQSSFSAKKKRMRTTEKKFNFDWDAEDDTSREHDPIYSQQSANRGNSLAGLGGEFDEEAERMAYKRARLIEERDADHGKHRAKGHLEDFYRARQRARERAERTGLGTHWSKKALNDMRERDWRIFKEDFGISTKGGSIPNPMRSWDESGLPPRLLDIVDRVGYKAPTPIQRAAIPIALQARDLIGVAVTGSGKTAAFLLPLLVYISDLPPLTEVNKNDGPYGLILAPTRELVQQIETEALKFAQPLGFRCVSIVGGHSLEEQAFSLRNGAEIIVATPGRLVDCIERRLLVLAQCCYVIMDEADRMIDLGFEDSVNRILDALPVSNEKPDSEEAENAQLMKRRLGGRDRYRQTMMYTATMPPLVERIAKKYLRRPAMATIGNAGEAVDTVEQRVEFISGEDRRKRRLQEILASKQFAPPIIVFVNIKRNCDAVARDIKAMGYSAVTLHGSKTQDQREAALGSVRSGQTQVLVATDLAGRGIDVPDVSLVVNFNMATSIESYTHRIGRTGRAGKSGVAITFVANEDADVLYDLRQMLSKSSISKVPEELRRHEAAQSKPVRGSASRKEEVVAGGGGGGGDRGDRGGGGGGGDRGGDRGGDRGAGGAGAGAGAGGGGGKGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJT7</accession>
    <name>A0A367LJT7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Leucine-rich repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_6436</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJT7"/>
    <dbReference type="STRING" id="1330021.A0A367LJT7"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000273">
        <property type="entry name" value="Leucine Rich Repeat domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF69">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 11-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="284"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="336"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="781"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="40"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="292"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="360"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="388"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="781"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI14681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="815" mass="89065" checksum="C3BAF45D62F6CE0B" modified="2018-11-07" version="1">MDSEDGEYFIKRLVTFVRTHEKSIANALQFQRREVRHRSSQSTGSASLSLSPTLPERPSTSSVSNSLAAAFSFGSINFTSHNAKSVRLALTPHHLFYLLSRFEELNIQVGPMKVRLEDLHDSSSTIYVSFLGNTGRSRSRNSDVGSIHSVSSMRSVMSGMSAIWTSFGIGASISAARTERHKAAIQADLKYLYSAFTKIPCLRLAPDRRARLIKGYEEFPFDSAVPLYVFKNLQALEIRSLDFRQFFGWDRLADQLRSLSLRRAGIEDPADILIDIVLDDMDKRRRRSSKSQVSPTATLTANASPRRSPTIPHLELVRAASAPGSPDTRSALADLRVGSMTPSDPAVEDTDVSDAGRTPVARDDADGPHRSPTRRARPRSNSPTRPASSRNYSSNVRSSQRMRRSGSGSSHSSMSDSWYYHGRGSSGNLLAMGVLPPTKWRFLRHLSLADNALTSIPQASLAPLSNSLRSLDLSSNLFGQIPDSLATLTALRALNLSHCMIDSLHSLTRSPLPAMTALNLRANRLRSLAGVEKLFPLERLDLRDNQLTDPRELARLTGMPDLREVWVEGNPFTRTHKNYRVTIFNLFRSTPGYTVDVMVDGHGPSYSERRQLVDRAPIPDSVPVVKPAKAPDTPTVVDVSKAAPTEVGAGSTRRRNKTSKRRIVDLASGDVSLPPLIVDSGPETVQEATKVQVSEVSPSDGYRTSRPSESVLLPPVILSPSGEGPSVGTADVGADFPADAEPHDWDVSGEIYRRRIQNLRDRVGSGYLSVLSEESWDGTGSFNAASSTSVPPLRAGHLSSNTMPAQAVHSGRSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJU0</accession>
    <name>A0A367LJU0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_6935</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJU0"/>
    <dbReference type="STRING" id="1330021.A0A367LJU0"/>
    <dbReference type="OrthoDB" id="5319458at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G12570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="10">
        <location>
            <begin position="330"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="563"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="635"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="565"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI14698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="692" mass="76624" checksum="D3342E369C85F273" modified="2018-11-07" version="1">MPGVANSSITITFTFTFTITFTFSITITITISSLLHILARGSCPAPASLAIPFLGFRAPSRLARDCDGKLPACTACEKAGRENDCSAANDQFARGKERSYVAALELSIEKLERRLQYAKSRKASVALHGPDASAMAHVDRRDSLASIRAAIHRKDAKSRENHDVNSIVSDFASLSVNATTRDFEPSASNITFAGLVLAATTNDQIPGPAPQGLPPRPAAHAMIQYFMANIYTLFPCFSETTLLTILDDVYQRDDRMVKDSGYWLLYMVLAIGATAQSQRINDDNYLHGLSFVSKALLYADSALAPGHVSQIQSLLLLTLYSMLDPAHFDSWHLIGFTARAVVDLGFHQDPPLSSRSDKAALDLRRRIFYCVYALDRAISMAHARTFSFIDEAVNVAFPTKPSSGRPLSMSGSMSGPQSADPALLVFQLRRAQSFWYQELYQSDPTPLPNPSAFLWQMCLEMREWGASLPNSLPTGTRRMLEQELWYSYVYCIAPSARAPHITDHSRMLIFEYSLAYLNSMHETACGGLNSAFYTYHDALKVYFMANQFIAVLRDAQELLISGTYVPPPPSPPGSAPAPPIPRRQLRPAEDNLERSLWCLSRIPETLGLYGTRWEDSMMLKQSFEQISTETVQALRKRQQMRTTTTTPPLADYQNGLPQPMAHHPPDQQSPPPVDVGWAAVDAAHMMPTAGHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKT5</accession>
    <name>A0A367LKT5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_6674</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKT5"/>
    <dbReference type="OrthoDB" id="4926283at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI15038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="16744" checksum="BA66E264FDDED7D4" modified="2018-11-07" version="1">MVLLPDPTAVLSQAAAAQGQEHVITRTLTGPFTTIKTLVALGSTAAASPDEIRPESELYGSQKGLSGAQLGAILGSIAAAIAILVTIAVCLSSRRRRNKNKSESVYNDNNSTTEAPSVVGSFSWSAEQERYPPELIPGGAPNPTSIRKPRNPPALSRDHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKX4</accession>
    <name>A0A367LKX4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome P450 monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_6658</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKX4"/>
    <dbReference type="STRING" id="1330021.A0A367LKX4"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11059">
        <property type="entry name" value="CYP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="4 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI15085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="518" mass="58671" checksum="1F52A71025520ED2" modified="2018-11-07" version="1">MLIILLAGLAFAYGLYSYVYFPIFLSPLNRFPTPHWSCSISHLFILRARKQGRENKVLREAHLRCGSVVRVAPDALSVDGVEAVRTVYQRGFDKWPWYSIFNNYGAPCIFSSLGSKEHSQRKRVLSHLYSKTFIQSSPALKAQSRAVLQGRLLPLLRREAVRSDRRGTEMQSILMATTMDLISAFIFGMRVSTNFLECEAYRRHWLNLYLVRHHNHFWPQELPTLTWLCVKLGIRLYPSYVDAANEELRDWNMQLCNKARDYLLSAEKREHSHQPGDEPVVFQALHAAVQEEDGVSIQQLLLPVASETLDQVLAGHETAGIVLTYLTWRLSQDPTLQTRLRAELLGLKPSRAGVDGTLPDVKALDDLPLLHAVVMETLRLHAPIPGPQPRQTPYPSSCIGGVQVQGGVRIAALAHTLHLNEAVYPDPERWHHSRWLDDGRGSETARRDMIRHFWAFGSGGRMCLGSNFAMNGMKLIAALIYSNFHTSIVEDDGMEQTGGYSARPRRNQLFLKLTPVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LL41</accession>
    <name>A0A367LL41_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hyaluronan/mRNA-binding protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_6611</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LL41"/>
    <dbReference type="STRING" id="1330021.A0A367LL41"/>
    <dbReference type="OrthoDB" id="5426471at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039764">
        <property type="entry name" value="HABP4/SERBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006861">
        <property type="entry name" value="HABP4_PAIRBP1-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019084">
        <property type="entry name" value="STM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12299:SF17">
        <property type="entry name" value="AT19571P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12299">
        <property type="entry name" value="HYALURONIC ACID-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09598">
        <property type="entry name" value="Stm1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01233">
        <property type="entry name" value="HABP4_PAI-RBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hyaluronan/mRNA-binding protein" evidence="4">
        <location>
            <begin position="108"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="221"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="234"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="260"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="274"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="292"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI15129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="336" mass="35494" checksum="8D96921953C012C1" modified="2018-11-07" version="1">MSNVASQNRFAFLGNDSDGEEKPTVPVKSVDKASSRTTKRHVEPQAPLPSALGSAGNRRGGLRGNDGAFRDRGAGSDRNHGRSTDEAPRDGPRGGYGARNRGGRGSRRPREFDDRHPSRAGGYGGSEKQSAQSWGAVDGEAELKDEQAGEAMARSEHKDALAEDGAAEEAAEPEDKSVSFDDYMAQLAEKKLALDSGFKLREANEGSKLDKKWANAKALEKEEEDFIAGTGGKTKRERERKTRQTVDFDPRFVEPERTRGGGGGGRGGRGGRGGRGDRGGDRGGDRGRGSISRGGGSISRGGGSISRGGRGGRDHESADVPINTDDKAAFPSLGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLA0</accession>
    <name>A0A367LLA0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Alpha-mannosidase</fullName>
            <ecNumber evidence="3">3.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_6947</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Degrades free oligosaccharides in the vacuole.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.24" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLA0"/>
    <dbReference type="STRING" id="1330021.A0A367LLA0"/>
    <dbReference type="OrthoDB" id="10261055at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004559">
        <property type="term" value="F:alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009313">
        <property type="term" value="P:oligosaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10812">
        <property type="entry name" value="GH38N_AMII_ScAms1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.50:FF:000004">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.110.10:FF:000002">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.30:FF:000001">
        <property type="entry name" value="alpha-mannosidase 2C1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.110.10">
        <property type="entry name" value="Glycoside hydrolase 38, N terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.50">
        <property type="entry name" value="Glycoside hydrolase family 38, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.30">
        <property type="entry name" value="Golgi alpha-mannosidase II, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054723">
        <property type="entry name" value="Ams1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041147">
        <property type="entry name" value="GH38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011682">
        <property type="entry name" value="Glyco_hydro_38_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015341">
        <property type="entry name" value="Glyco_hydro_38_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037094">
        <property type="entry name" value="Glyco_hydro_38_cen_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000602">
        <property type="entry name" value="Glyco_hydro_38_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027291">
        <property type="entry name" value="Glyco_hydro_38_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028995">
        <property type="entry name" value="Glyco_hydro_57/38_cen_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46017">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46017:SF1">
        <property type="entry name" value="ALPHA-MANNOSIDASE 2C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09261">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22907">
        <property type="entry name" value="Ams1-like_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17677">
        <property type="entry name" value="Glyco_hydro38C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07748">
        <property type="entry name" value="Glyco_hydro_38C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01074">
        <property type="entry name" value="Glyco_hydro_38N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00872">
        <property type="entry name" value="Alpha-mann_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88688">
        <property type="entry name" value="Families 57/38 glycoside transferase middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 38 central" evidence="9">
        <location>
            <begin position="552"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00054985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI15189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1077" mass="121684" checksum="D4CFC8B00B4B76ED" modified="2018-11-07" version="1">MGGGGQVKSNSSYPVFAHRPVGVPKTSILKDRIEPFYKSGQYDKVNLLANLYKARYSGEPHVRLYVWSAPKLQRPTFDEAVSHEFNETKTGASFGPSWSTHWFRVHLTVPKDVIDEELVVLEWDAGNEGLVWTEDGTPLQGLTGGGERIEWIIPKSLRDAREHVIYIEMACNGMFGNAPSGKTSIAPPDPNRYYTLSRADIAVVNVPARMLLFDMWELGDAARELPENSAEQSHALAVAMKIIDTFQVNDQESIVECRKLAREIIGPDVDSRRVYDVGKDPVVFGIGHCHIDTCWLWPWAETKRKICRSWLSQCDLMDRYPEAHFACSSAQQFKWLKRYYPSAYERVKSKVAAGQFHPIGGSWVEHDTNMPSGESLVRQFFYGQRFFEKEFGSRCRTFWLPDTFGYSSQLPQLCRLAGMDRFMTQKLSWNNINTFPHTTFMWVSPDGSQVICHMPPSETYTSEANFGDLSRSITQHKTLRVDSSSLLVFGKGDGGGGPTWQHFEKLRRCAGISNTVGGIPKLKLGLTVDDFFDRLAPKANEFPTWHGELYFELHRGTYTTQANNKFFNRKAEVMLRDLEQLATFASIKDRGYSYPWKEIDDMWQNVLLCQFHDCLPGSSIEMCYDDSDKLYAQVFKRGQALLEGLYHSMKISEARPSSSKESVVLNTLPWHREEIVQVSDTEVVIASGDGQLLDMRAFKPEDDKSAVRLTEQDGVFVLENDNLRVVVEGGCITSLYDRVNDREVVEKGGKANKFVIFDDIPLFWEAWDVEVYHLETERQLTYGKTKVHESKPHRVTLVTDIKISGESSLKSYISLAAAIPGQPSQVDCSAEVDWHENSKFLKVEFPVEVVSTEASYESAYAITKRPTHYNTSWDMAKFEVCCHKFADLSEHNYGVSILNDSKYGFATVGKTMRLSLLRAPKAPDAHADMGHHAIRWAIFPHKGYLSSQTVRAAYAFNNPLKLLSASSAEAKHSLDAPIKLVNLDESGSLILDVVKRGHEGEVNYYAFAPAAGATSMILRVYESLGGRSKGVIRTKLQVKRVAKCNILEDELEEVKMADGEFFIELRPFEVATYAVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLE1</accession>
    <name>A0A367LLE1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6695</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLE1"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="126" mass="13759" checksum="35F6A499F130CA0E" modified="2018-11-07" version="1">MGRTDRRDGDENSEALRTSTRFVYTLVDGATYCSSAWRGAKEESKRKGPRGTRKKEKKNEDIATRPGGRETPPGPGPLRAVPPGIHPLFGGRVGPVAGRQHRPSPALRHNRGATERRPPRLPCGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLM3</accession>
    <name>A0A367LLM3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Borealin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_6525</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the borealin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLM3"/>
    <dbReference type="STRING" id="1330021.A0A367LLM3"/>
    <dbReference type="OrthoDB" id="2392550at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032133">
        <property type="term" value="C:chromosome passenger complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051233">
        <property type="term" value="C:spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018851">
        <property type="entry name" value="Borealin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018867">
        <property type="entry name" value="Cell_div_borealin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16040">
        <property type="entry name" value="AUSTRALIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16040:SF7">
        <property type="entry name" value="AUSTRALIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10444">
        <property type="entry name" value="Nbl1_Borealin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Borealin N-terminal" evidence="11">
        <location>
            <begin position="52"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="113"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="173"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="235"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="267"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="324"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI15334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="346" mass="36971" checksum="9C2D90CF8F045AD4" modified="2018-11-07" version="1">MAPARRRSRPSDSSTRRDDASRGTKIPLKGSPRTPHHRSPIKKRKNGISLQQKQALIDNLQLEVTERARRLRAQYNLQAQGLRSRVEIRVNRIPRSLRKLKMGDLLLKHLEQEQSRAAAPPPVKEAAKPATRSQVPERVHHAVGTELARDKENEGASLKGKKKTRGPDVGTVRPTQVLSPTSSNSRLATRHSPPKTQIAQPGSPLKTSGTGRTAAVSGVLSSMVERAKATRYGSTRKPTAASSRSSSTTAATRARRLAAKPLPPAATRPVTRARASGTSESSEGSTTTVVRKAATNTAAVAAAAASKKRTMGVIRKGVTGGGMKKAAPKPAAPASKTTGRSLRKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLY4</accession>
    <name>A0A367LLY4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycosyltransferase 2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_3428</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLY4"/>
    <dbReference type="STRING" id="1330021.A0A367LLY4"/>
    <dbReference type="OrthoDB" id="5819478at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36851:SF1">
        <property type="entry name" value="GLYCO_TRANS_2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36851">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="522"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="552"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="3">
        <location>
            <begin position="282"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI15446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="663" mass="73952" checksum="3D204636F0207990" modified="2018-11-07" version="1">MSVFAWCSRRAGGLSMLALLALCYWVISDEWITKRPVPGLRPVPPPVAGASPQPSSPSGNSIWTLVFAYYCLLIHVLVFIFPLRACWSVWNVTHSLRRMTHSNGRAFHNLKIGLRRRGSSTSVSSSETLTSDSLMSESNGCSSATSEASDLEPEMYTDGTYVSEDSVIHAIIIPNYKEELDTLKETLDVLASHPRAQFSYDIYLGMEQREVNGESKALSLIQEFVKKFRSIDYTLHPADIPGESAGKGSNLGWAAKKLSAKYSMGVRKNVVVTGIDGTRAFVHGSDSHLSPSYFTNVTFMHLLHPETAATTLYAAPIIFDRNAHKVPAIVRVADILWCAAGISGLYKGSTVAPPTSVYSLPLVLVDRVGGWDCDAEAIGEDLHMYLKCFFALNGNLTCRTVLSPVSQSNVTGGGKGGVRGTVIDMQARYKQALRHMWGALDTGFALRKAAEMWQERKHTSRAFRPLHRSHGDGTDCYFPIDQLSDNSTRETGVFSDVTHDTLKEPHWEHLFYLFHRLFEAHFLPVHMTILILASTLYLWVVDGKHDTDNLGWVFTICNVLRTLGFVEVACYLFLYESFHRICVKTRRREMNKAKLADGMCFSNRTIRRNLIDYVLVPLVAPLYGAIPCAQAEISHFWTVDLVYTVSMKVTRQRARSSVTADLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMC2</accession>
    <name>A0A367LMC2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF1750-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_3351</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMC2"/>
    <dbReference type="STRING" id="1330021.A0A367LMC2"/>
    <dbReference type="OrthoDB" id="5321006at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013859">
        <property type="entry name" value="Ssr4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046464">
        <property type="entry name" value="SWI-SNF_Ssr4_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20497">
        <property type="entry name" value="SWI-SNF_Ssr4_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08549">
        <property type="entry name" value="SWI-SNF_Ssr4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SWI/SNF and RSC complexes subunit Ssr4 N-terminal" evidence="2">
        <location>
            <begin position="5"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="SWI/SNF and RSC complexes subunit Ssr4 C-terminal" evidence="3">
        <location>
            <begin position="253"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="SWI/SNF and RSC complexes subunit Ssr4 C-terminal" evidence="3">
        <location>
            <begin position="552"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="448"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="515"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="549"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="592"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="625"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="673"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="729"/>
            <end position="741"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI15586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="767" mass="81457" checksum="E67A95089196BC1B" modified="2018-11-07" version="1">MAQQQDPSHSVPQDLMSHVHLISAFRYPTMPRLDLNDVAKWLMSAPSVARDRAPFFWTYLDKPTDGTILLTWQPLQRLGTNFATDGFIWAPPEHVYKQDLGNGLMLEIFYLKAGYMIGEQYALHARRRFRLIPVPGHPNSPQPDSSLFIVHYGPSEPNDRIPAAAVPYDERVNAIMQQRHYLLRAGQIRRKEFMLSDRVNWPSLPELTRQQMGPQMLPRGVPQQMAYPVQPVHGPPNKRPRYGPQPATAEQAFEDEEDVTRGDMFDSLTQRDISLSRYQQNHEWMEEVLSSPYRMNQITPADLNLGLKGELASLTEGIFTAQGADVLARTPEKPYIGRLDPGLADEFRKRVKEHNKKTLAEMEKMRIAHAEAMADVRTTSIYAVKEAELRAMGRHSASPKPEDESGPGEFESSSGQRSAQTEEEVVKEVEAAVGCKVEKLPLIRRLQQGGYQSSTTQGGTPTAQTSRQQSRAGSPNSSNVAGESSDADMGGTAAAMLGQMHTGLSTPVNSLPTPQAQVSAAQSNVATPLNGPSAASPAPAPAPVPAPAPVTSSSAPTSAPAPAPAPAPAPAPVPAPAPTAAPTAAPVPAPTSTPTATATPPQADVTMEGTAEATEGTVEETAPAAEKKKEEDRSTAPDQGTGSGDWVVVPKSGETAEGQAAQDRSAGPTSGDATKPTSAPTVKPAASSAATPAVTEGGSATFDQNDFSSLGDLDTAGDALSGFDAPDMDGAAGELGEGLDLQMDMEDSAFGEAFDGVDTAGGGARSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMM6</accession>
    <name>A0A367LMM6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Haloacid dehalogenase-like hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_3370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMM6"/>
    <dbReference type="STRING" id="1330021.A0A367LMM6"/>
    <dbReference type="OrthoDB" id="10255128at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050849">
        <property type="entry name" value="HAD-like_hydrolase_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181:SF1">
        <property type="entry name" value="COLD TOLERANCE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28181">
        <property type="entry name" value="UPF0655 PROTEIN YCR015C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12710">
        <property type="entry name" value="HAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI15641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="29577" checksum="52D4ED5195BE998B" modified="2018-11-07" version="1">MYLIFDFDGTITVQDTIGELAASAVAWQQRLGCSLQGAWDEAVRAYGSDLAAAEKTKREERRTVEDEIEFLAEARTVEEASLNRVERTGIFAGLGRTDMFRMGAEAVREGRITIRAGFGALTERAAGSGWRTCIISAHWSGAFIEGALSGTGFCGEVRANEVDGASGRIGGGITTSADKVAALRRLVAVYDDDDADATVFYIGDAMTDFECLIKEAGGADYGVVMAGDGDESSVLVRALRRLGFEVPAVGEMRRRGVRIGWAGSFDEVCLDDVASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMR6</accession>
    <name>A0A367LMR6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_3475</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HscB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMR6"/>
    <dbReference type="STRING" id="1330021.A0A367LMR6"/>
    <dbReference type="OrthoDB" id="448954at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051259">
        <property type="term" value="P:protein complex oligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.20">
        <property type="entry name" value="HscB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004640">
        <property type="entry name" value="HscB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036386">
        <property type="entry name" value="HscB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009073">
        <property type="entry name" value="HscB_oligo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00714">
        <property type="entry name" value="hscB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14021">
        <property type="entry name" value="IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14021:SF15">
        <property type="entry name" value="IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07743">
        <property type="entry name" value="HSCB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47144">
        <property type="entry name" value="HSC20 (HSCB), C-terminal oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="28"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Co-chaperone HscB C-terminal oligomerisation" evidence="4">
        <location>
            <begin position="100"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI15709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="176" mass="19925" checksum="CF585652C8C31E63" modified="2018-11-07" version="1">MSSRSLIVLKAASRATTRTITRPFEIDVAALRHEFLRLQAAHHPDKQPPDRKAAAEAMSSDINHAYRTLADPLLRAQYLLRLRGIDVTDDRNNAHDDADLMEIALEAYEAVDAATELAHLEDVRTQNDRRLSACERDLQTAFANDDAVAAKRLAVRLLYWVRIRDKIEAWEPEALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LN90</accession>
    <name>A0A367LN90_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Copper acquisition factor BIM1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_1702</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LN90"/>
    <dbReference type="OrthoDB" id="5329488at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21176">
        <property type="entry name" value="LPMO_auxiliary-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046936">
        <property type="entry name" value="BIM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046530">
        <property type="entry name" value="BIM1-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992:SF10">
        <property type="entry name" value="COPPER ACQUISITION FACTOR BIM1-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992">
        <property type="entry name" value="HYPHAL ANASTAMOSIS-7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20238">
        <property type="entry name" value="BIM1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016685988" description="Copper acquisition factor BIM1-like domain-containing protein" evidence="8">
        <location>
            <begin position="21"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Copper acquisition factor BIM1-like" evidence="9">
        <location>
            <begin position="17"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI15851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="231" mass="24522" checksum="5041BCD5DAAB136C" modified="2018-11-07" version="1">MRPVDLLGVALAAIVASAHSVITYPGWRGNNLITNSSFPYGMQWMYPCGGTTTTQNRTYWPTTGGALAFQPGWFRGHATAAIYVNLGFGTDGPDGGPPNMSNPMVHPFQLNGPTNNPYPGTVCLPQVPLPANSSVKAGDKATIQVVELAQHGAALYSCVDIVFADPGDSRITEVNETNCFNSSEIGFADIYTITTKDAHIDSQRKASIGPVSRVSWALTLAFITGGTWVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2024-05-29" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LN95</accession>
    <name>A0A367LN95_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LN95"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="75" mass="8476" checksum="FEAC631B4D3C9EBC" modified="2018-11-07" version="1">MSPHHACSGDLPKPPPHSSWLSILTHHHHHHHHRLSASSSPSLYPLCNVISLPFHQIKTPKPYLSTKTLHHHGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNG1</accession>
    <name>A0A367LNG1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">N-acetylglucosamine-6-phosphate deacetylase</fullName>
            <ecNumber evidence="2 8">3.5.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_2737</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate</text>
            <dbReference type="Rhea" id="RHEA:22936"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="3.5.1.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="11">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the metallo-dependent hydrolases superfamily. NagA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.25" evidence="2 8"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNG1"/>
    <dbReference type="STRING" id="1330021.A0A367LNG1"/>
    <dbReference type="OrthoDB" id="10264777at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008448">
        <property type="term" value="F:N-acetylglucosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006046">
        <property type="term" value="P:N-acetylglucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00854">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000065">
        <property type="entry name" value="N-acetylglucosamine-6-phosphate deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003764">
        <property type="entry name" value="GlcNAc_6-P_deAcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF14">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038994">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="12">
        <location>
            <begin position="64"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="223"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="247"/>
            <end position="248"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="342"/>
            <end position="344"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR038994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI15958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="425" mass="45519" checksum="F1CEEF46500721DB" modified="2018-11-07" version="1">MPIALSPPRSGLTKLTNCRLVKGDRLVDEDLWVSSATGTIIDSQASFYDDLSQPDETLDLGGRIVAPGMIDCQLNGAFGFNLSTLLDDMSQYGKKVRELNRLLVTKGVTSYLPTITSQRPEVYQKALPYLGPSGSRRMSGEGAESLGAHCEGPFLNPTKNGIHDVDSLIVAESFADIEACYGYDNVNGPKPPVRLVTAAPERGRMSDLIHDLTSRGIIFSVGHSEATYEDASEAVAQGATMITHLFNAMRPLHHRDPGIFGVLGQAESRPRPYYGVIADGIHLHPTTVKIAFNAHPEGFILVTDAMHVAGLPDGTYPWTNGGQTSSIVKTGAQVLLENSRTIAGSMTTTSSITLLECVNNFLSWTGATIPQALRAVTATPAAMLGLQGIKGTLEPGADADLVVLSEVDGKLELDEVWKFGRTVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNK8</accession>
    <name>A0A367LNK8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome b-c1 complex subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Complex III subunit 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_3046</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The complex plays an important role in the uptake of multiple carbon sources present in different host niches.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with cytochrome c oxidase (complex IV, CIV).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UQCRQ/QCR8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNK8"/>
    <dbReference type="STRING" id="1330021.A0A367LNK8"/>
    <dbReference type="OrthoDB" id="6683853at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.210:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.210">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004205">
        <property type="entry name" value="Cyt_bc1_su8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036642">
        <property type="entry name" value="Cyt_bc1_su8_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12119:SF2">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12119">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX UBIQUINONE-BINDING PROTEIN QP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02939">
        <property type="entry name" value="UcrQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81508">
        <property type="entry name" value="Ubiquinone-binding protein QP-C of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI16026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="104" mass="11680" checksum="93703BA0C76D13D8" modified="2018-11-07" version="1">MRPSRVLLSDAAPDWRTGSYLGPWGAMGGTKQRGIIHFGISANRQNALAGAGHDAVFNTFRRTRSQIVYWLLPMLGGYYIMNWAIERNEYINSKAGRAEFGDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LP81</accession>
    <name>A0A367LP81_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_3102</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LP81"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI16191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="141" mass="15894" checksum="2E1B748BBA022B0B" modified="2018-11-07" version="1">MFFYPVRPTPLTGAYPGNQLLLVRCRSHKAQTLELSPYNLFFSTLALSTVLWQPTGDVDCETRGPTLGRQGRMDDSNPGVQLVQVNATFIKCTECLRCDGLYDSNITVLSRVDLIDDGSSLDYIRFMSMILPTITNIRRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPJ0</accession>
    <name>A0A367LPJ0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPJ0"/>
    <dbReference type="OrthoDB" id="5418749at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42030">
        <property type="entry name" value="DRBM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42030:SF1">
        <property type="entry name" value="DRBM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="170" mass="18256" checksum="D10CD34942B7C345" modified="2018-11-07" version="1">MFGRVDSALQSSAAKPTSPLPSFNSFPSDAVSLHTREAFALANHPSGGRTAWSSIVVVHGKTLEARFWYDGKNINNATEDAAECAVKWLIASAAGEARICSEGAEQVLLGLEAAAWTGRDLGSPRGKRFDPHKSASLLGRLVQPCLLGFREIESHQAMVIRLDGCRPILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQ04</accession>
    <name>A0A367LQ04_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_3202</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQ04"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI16322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="96" mass="11050" checksum="DCE8203450B26A58" modified="2018-11-07" version="1">MVDKADESNQEQTKRDDGVSKAPPFQHYGHDTTRHDAMCKPARLARGCFAFLLLRCSNMPVFLHFFILFISRQACGVVVQTQYYVKLTIRTDLTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2024-05-29" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQ07</accession>
    <name>A0A367LQ07_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_3108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQ07"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI16499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="96" mass="11122" checksum="951AB5126A3D3A3E" modified="2018-11-07" version="1">MGVLQVGTLKYLEKIISISFSYLLNTNTSPASNSSSIASFRPLPRVQLSDSGYLYTFNQLFTAFLFLHRPTKYLIRFHFSNAFQQTYPLFPHIFPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQH8</accession>
    <name>A0A367LQH8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Shugoshin N-terminal coiled-coil domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_3273</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the shugoshin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQH8"/>
    <dbReference type="OrthoDB" id="5394106at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011516">
        <property type="entry name" value="Shugoshin_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07558">
        <property type="entry name" value="Shugoshin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="6 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shugoshin N-terminal coiled-coil" evidence="11">
        <location>
            <begin position="17"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="104"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="206"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="14"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="210"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="257"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="323"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="423"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="510"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI16492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="542" mass="59893" checksum="FCACCEB2C0ABB32A" modified="2018-11-07" version="1">MARLNEPIVSTDPLETLRKKMLRQNRELAKSNNARAQRIRDLEKDCAYMLSENLELRGRILELERQVEDSETRRIADHALAIKSKLESQLADFSALVAGLGVEPPLKRTSTQQQRRQTRPRLSFSASRPSPSQRRLRDVAREIEDLGYISENKSGPRRSMKYALPPPLCLPEQILALRSQADLVDSPELGPPPLSMFIDEDPVKIDSPCKATTETPQAPSPSRRTVESPMAFEEPLPSPVAERSWPSPATARNTVKIGEKRKLAAREDLGGFPSRQKENQMVETETEKKKKEEKKAETKNAKDVGNSERERSKGRQPLAAKSTNEHVRSPKKDGTATTKPEPPKVKSSQARARGKTKSSIPPMDEASAEEKGPSFPERPLLAILPPSSPERLPTAPNLRDKMRRPSKQLFDAVAGEGKKTNRPSRSSSDASPLPASHLPLPSPSRAAKQQSADPASCRRRSRSCRRSETVEGEAQGSDEVDVYEFASSSPPSDADDESGRPARSGSRRQTLASSSSRTPSTTTADRGGSESGQRDRRRSMMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQL5</accession>
    <name>A0A367LQL5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL15/eL18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_2499</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQL5"/>
    <dbReference type="STRING" id="1330021.A0A367LQL5"/>
    <dbReference type="OrthoDB" id="361383at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_uL15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_uL15_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01071">
        <property type="entry name" value="rplO_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934:SF11">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="6">
        <location>
            <begin position="114"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="57"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI16736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="296" mass="32583" checksum="8907104CC4234635" modified="2018-11-07" version="1">MLPRLLPIKTLAYRVTSTKPASLSLTNRLAGIALQQARHASILASLANNKGAVRQVRRVGRGPSSGRGKTSGRGHKGRKARGNVKPWFQGGQTPLIRKLGSKGFENKRAPRMTEVNLDSLQQWIDHGRIDATKPITPREMILSKLTSSVKDGIKILARGTLRQPVQLSVSRASAAAIAAIEAAGGKVVTRYYTKMSMNRLARGESIHTDEPLPVGSHHVTKVLKASRKTGFKYRLPDATSRRDIEYYRDPAHRGYLSHQLKPGESPSLYWDVPAEKKAGGAVRKNMSKDAKVQTMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQM1</accession>
    <name>A0A367LQM1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ataxin-10 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_2686</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May play a role in the regulation of cytokinesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ataxin-10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQM1"/>
    <dbReference type="STRING" id="1330021.A0A367LQM1"/>
    <dbReference type="OrthoDB" id="379794at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051374">
        <property type="entry name" value="Ataxin-10/CTR86_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019156">
        <property type="entry name" value="Ataxin-10_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13255">
        <property type="entry name" value="ATAXIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13255:SF0">
        <property type="entry name" value="ATAXIN-10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09759">
        <property type="entry name" value="Atx10homo_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ataxin-10" evidence="7">
        <location>
            <begin position="830"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="442"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="760"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="918"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="449"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="467"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="760"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="787"/>
            <end position="796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI16687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="969" mass="108166" checksum="BEA39786E109231F" modified="2018-11-07" version="1">MAYANASKEAMARLADYAASPGADAGVQVGETIEERCFSAALICLEGHYTHSPPMGSLTAARVSSMISKTLEKTHTLRSAREALSRNVAIWIWLTRIFAAAIPSLTARSIGPLSSLGDPNKSVTPQESTALIITNQASIKEDLATLIKLMHIARNLLVNAEPEVPQDLCAAVHFDQMVYQTIILCVNVSSKGYDGEILDDAQRLKLTDITELYKKLLVTSLQQAHNWTAKNDRNKMSFWYDVLFDEDETAYNSVPDEGLGDGSGFRLDTAKQQVQHWLDRNSKMCDTARKLLKDYAQNQADKPPGRLAPIRPLAWNWLPDGSVPSPADLGDDGDKFNPVWNPHETDRFEQDRAYGRVSREIDTWWLRARDPNYEDWVAGMPSIEFAQSRTEHCKDNLVQRYANSYHGEQSPSVERAGEDILEPEHCHCSDCHHAQHTESVAAQDGACQHPDHDRHQHANHEHEHDHHQHHHQHHHHQHQHQHDHHHHHHHHDYAHEYVDDVMDEDEAEDDMSYVEGPLTGILTEVPNILDPKQIEALHMIIKSCVLDNAGSGLTRAGENLQKTRCRMLLALDCGKSLLRELLVFIAVWGKDEQSLIFQVTTQIVEALHHSALIPYAWNSLRIPKDIISPAQTVLLRLVNHMLRARVHSPTGQEAKDETRDIKLVHFFFSFFRSRIVPECAALMHLQAQIRQQTCDAAEFPVDSWDMERAKDGLAQYLDFLITVAETTDTRAKLIEWEAAYDLVALLGGLDAAVEKKPLVELPKRSPKREKSNPMVERPYSTADGSPSPSPPPPPMQEPAHKFPWRGIKGQIFTIIATLLQPPAGQSSPGNAQVQMQMVRHNGIVPLLNCCAYDDHNPYAKERVTICLKWLLDGCEAANNFFRELVSFAPPASLKPPAGGSTVSSVRVDGVAGEVKVQVRSSNAPRLGGGSSSRSSSRDPDADLLDRAAALSLTVSPPTSRGSIEDDFMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LR46</accession>
    <name>A0A367LR46_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1479 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LR46"/>
    <dbReference type="STRING" id="1330021.A0A367LR46"/>
    <dbReference type="OrthoDB" id="8249012at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010856">
        <property type="entry name" value="Gig2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613:SF1">
        <property type="entry name" value="DUF1479 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G09280)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBIU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07350">
        <property type="entry name" value="Gig2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="646" mass="70967" checksum="0D9A3C024F2D0E19" modified="2018-11-07" version="1">MAFAPAIGDGSRARMPVENTTSLRLVAGETEQGDEMDQVEATTTKKNHSKKQKKTVFETDSDPDNRMSFWGGPEPVPLPPRFERIKRNLIAGHEAAVEASWPRLIHALRAEVEHIEGLGPHLIPSIEFADVDDAAQTARFGRDLRRYGVGVVRKVLDPRTADEAVRDTVRYLHRRQSHVSRRSPSSSTARFRAPRQDPTCFDCFWTPAQVRCRAHPNVLRAQRFLMSLWDTGSDQRLNTNLPISYVDRVRVRGPGFDTAPPASESCSADASSFPASTSSPSSSPPPSSSSYPSSSVDSSPTVSSPSSVAANDAENASGRFWPPQPPPQQQLLAGQSADDWITALQSSAGVVAQVDNGSLERWEPDGYGRCGTYDRIFQGCWEQYDPWQCASRVAATIDLYNGYGSCSIFRMFQGLLALSTTEPGMLRLLPSPRLATAYYLLRPFFSPRRPAPNSPRPGPDWDAYLDPSNWELQSEPDTIIHGAVPGHAQRLTERWHPHLHLRSSLVTLPTLQPGDYIFWHPDLPYHFSNSDAASAAVATTPAAASSSPNPYPVSMLLYVPAAPLTQTNALYLARQRKAFRRGHPGPDFDTLGRGIVAEDPGLRPGDEEIARVGGVEALRAMGLAPWEPRGRPSAVVDLANLILFPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LR86</accession>
    <name>A0A367LR86_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">XPG N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_2066</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPG/RAD2 endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LR86"/>
    <dbReference type="STRING" id="1330021.A0A367LR86"/>
    <dbReference type="OrthoDB" id="17262at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09902">
        <property type="entry name" value="H3TH_MKT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09858">
        <property type="entry name" value="PIN_MKT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022039">
        <property type="entry name" value="MKT1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037314">
        <property type="entry name" value="MKT1_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022040">
        <property type="entry name" value="MKT1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF32">
        <property type="entry name" value="POST-TRANSCRIPTIONAL REGULATOR MKT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12246">
        <property type="entry name" value="MKT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12247">
        <property type="entry name" value="MKT1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="3">
        <location>
            <begin position="16"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Post-transcriptional regulator MKT1 N-terminal" evidence="5">
        <location>
            <begin position="314"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Post-transcriptional regulator MKT1 C-terminal" evidence="4">
        <location>
            <begin position="484"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI16964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="731" mass="82584" checksum="578B8701DDCB02E0" modified="2018-11-07" version="1">MPFLVEDTWINAQASTCDVSDLQDCAIAVDATYWLNHLLDLPPAHEPLLPALGGLTGIHTHINENLDHWEKNGIVPFFVFDGQSITGQDDVALSRRRAANQKTDDAWELYLQSRAEQAVATFGANPGAYNVQNLYPLLQVILKKRKLHFLVPPYNASAQLAYFELIDSDQCAGVMGSLELLLYPIKDSVFRAFDWEAKTVTFLSKKKVMRVLSVSEPMFIDAMLMTGTSFIPPFPPLLDTSMYPNPYTIMDAVNLLRTSDKSITTACASFNDILQTQDPDWLDKYRKARMAVHHFIFVAENGEVRVNDFERLTKDSHEYLGLQLPAELFHYLNTGLISSRNLNCITHSQIVVQPTLDGVASDEYRKLVTEKILPLKEQALGLIIPRVHRGIGHKDITMRVWFDAKFAYKINHRALQPAPSQRVGTWDVKEADLHKLYPSNLWGPISLEVLALVNEDFAEMTKAKDRVIRGIDSAQMVTSVAIWRFLHLRDYVDDQHRLTRWGHALAATLLAVRDGVTENAPEMPALDEAVLLAFELIRFDVLNSKYGEGLPGMPRKGSDNDKSSLVLISRCATLLEMRHQVYGYTGPLNKSLLAFRSLSSTVREAARDLMEAIVASMFMYGQSKRERDDYLDISQRLPFLREPDIGLGVAMRTFFDDDDVNDSQEKRAYNLSEFPKTFVPFAEALADDFRLCVKFVRALNVGVQLVEGKDLSAADRESWARAKAYLDARPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRG9</accession>
    <name>A0A367LRG9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRG9"/>
    <dbReference type="STRING" id="1330021.A0A367LRG9"/>
    <dbReference type="OrthoDB" id="4590138at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39474:SF1">
        <property type="entry name" value="FUNGAL SPECIFIC TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39474">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI17046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="176" mass="18635" checksum="AF216A4B984B779E" modified="2018-11-07" version="1">MLFPLSLASKSPKIHHSHILPGLFLLPPRPRHLPVASLNSKNLSASSSHTPRQQSQPPSAVDDQTPPPSPPAAGETTASSSSSPPRFALPAPGVDDDSSNSKVPLPVGGRSVKLADLGPLVMDKNGTVSRIANWTELTSSEKNIAMIVLDKRNRGRREALQGKLNSMSKNVSDNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRI5</accession>
    <name>A0A367LRI5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AMP-binding enzyme C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRI5"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016703923" description="AMP-binding enzyme C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI17028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="15744" checksum="8A12AF322EB1F6C1" modified="2018-11-07" version="1">MAAPCYGIWGLASLDWILAASDFVIWCEGIVVEILGDALQLEKSEAAAQIAVCICLQVAELPQRVVTRWHPTGHQVVGPEAVVETLTARRILDGLPFSSLPSERVSFLGSTLRPGFDRAKAGVVKGQARIDDRCNNKGGKKQYRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRL5</accession>
    <name>A0A367LRL5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_1798</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRL5"/>
    <dbReference type="STRING" id="1330021.A0A367LRL5"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF40">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="3"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI17058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="143" mass="15639" checksum="3D071063F9F496F5" modified="2018-11-07" version="1">MPLTGHCLCKAVTYTVDVDQPIMTGYDHCDDCQRQTGSTYYSYCYAALVALVPKDKLTIKGNVKRWAGKGASGNAVYRVFCPDCGSPIAHEPQANPVISVLKAGTLDTEIKKTLKPTVEIWTAGKLPFCQEKLPKAFEHMPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LS04</accession>
    <name>A0A367LS04_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_1848</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LS04"/>
    <dbReference type="STRING" id="1330021.A0A367LS04"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF252">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="127"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="282"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="25"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI17198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="439" mass="47085" checksum="340885337DA16EB2" modified="2018-11-07" version="1">MDFKSTYSDTRPFAALDKGPDSPPSSPRLGLKQWLQILSTSVVFTNTWGFLLSSGALQLHYAQSLIPHESSSNISWISTTCAFFVLSSGVVTGPLYDRGYYRALLLGGSLLQVFGLMMLSLSTTYYQLFLCQAICVGVGAGVVFTPSVSAAAAFLPDPATRARAVGLMASGSCIGGVIFPLMFRSLVPQIGFPWTIRSMAFLTFGLYLLSYLVLLDGGLEQYSSPKMRRRFFDSSVLRDPPFLVLVGASLLTAIAYYIPLLYLPIFTLIRIPTVSPSQTIDLLAIINGSSVLGRLSAGLAAAVVGPTEVSSVCLGLSVVILLGWMAVYTFAGTVVWSVFWGMASGVLVTLPGAFVPLFCPSMDVIGTRVGMYWVSAGLGMLIGSPMAGAIHDAKPGKDDAWRLQLFAALFMLGSAVSFLYPLQHLRRKSRKAGPDAVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LS82</accession>
    <name>A0A367LS82_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Diphthamide biosynthesis protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_2240</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2 [3Fe-4S](0)-[protein] + 2 Fe(2+)-[Dph3] + NADH = 2 [4Fe-4S](1+)-[protein] + 2 [Dph3] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:71239"/>
            <dbReference type="Rhea" id="RHEA-COMP:17997"/>
            <dbReference type="Rhea" id="RHEA-COMP:17998"/>
            <dbReference type="Rhea" id="RHEA-COMP:18001"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:33723"/>
            <dbReference type="ChEBI" id="CHEBI:47402"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[3Fe-4S](1+)-[protein] + Fe(2+)-[Dph3] = [3Fe-4S](0)-[protein] + Fe(3+)-[Dph3]</text>
            <dbReference type="Rhea" id="RHEA:71235"/>
            <dbReference type="Rhea" id="RHEA-COMP:17996"/>
            <dbReference type="Rhea" id="RHEA-COMP:17997"/>
            <dbReference type="Rhea" id="RHEA-COMP:18002"/>
            <dbReference type="Rhea" id="RHEA-COMP:18003"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:33751"/>
            <dbReference type="ChEBI" id="CHEBI:47402"/>
            <dbReference type="ChEBI" id="CHEBI:83228"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DPH3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LS82"/>
    <dbReference type="STRING" id="1330021.A0A367LS82"/>
    <dbReference type="OrthoDB" id="66964at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.660.10:FF:000001">
        <property type="entry name" value="Diphthamide biosynthesis 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.660.10">
        <property type="entry name" value="DPH Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044248">
        <property type="entry name" value="DPH3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007872">
        <property type="entry name" value="DPH_MB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036671">
        <property type="entry name" value="DPH_MB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454:SF31">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21454">
        <property type="entry name" value="DPH3 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05207">
        <property type="entry name" value="Zn_ribbon_CSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144217">
        <property type="entry name" value="CSL zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51074">
        <property type="entry name" value="DPH_MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DPH-type MB" evidence="9">
        <location>
            <begin position="7"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI17220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="84" mass="9234" checksum="5FAE869162113A72" modified="2018-11-07" version="1">MDEDIAIYDEIEIEDMTFDEALQLYHYPCPCGDRFQIAVDDLRDEQDIAVCPSCSLMIRVIFDLGDLPSPPPAGKGAGQVSIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LSC1</accession>
    <name>A0A367LSC1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LSC1"/>
    <dbReference type="STRING" id="1330021.A0A367LSC1"/>
    <dbReference type="OrthoDB" id="4205486at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI17311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="309" mass="33549" checksum="A244AB72D0DE062B" modified="2018-11-07" version="1">MASKLGPEMIAKVKPRSVKDATRFTSTVPHATSKTASQAPPLPKTSSWKPGETAEQRVVRLRQAHLAAQRAQIKPMDRVIDSMRVFLDATHKLTINGIILFTVEEGEANGHSVDALGLAALVSIYSVWDMLRFNRARRAEWIQIQKRLESDELSAARIAYLKGEGTEAQIALVEEANREAERLGTKLPPLLPPPEQRTHFEETVKPVLVRRDQSKDGKGIFGIFSGIFGGSSSGDEAAAAAAAVVHDGPAPSDVGGTGTIVQAVEASAKGAWETEKERQRNGGSLDRLGLEDGDSDRLSSSGSRRWRPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LSK5</accession>
    <name>A0A367LSK5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_2672</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LSK5"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI17389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="262" mass="29600" checksum="5E23B456AFA1FE95" modified="2018-11-07" version="1" fragment="single">HALQRNGAANIDNINISNYLGCPAPECHIRQGLSAADPAEGDPRPAFFFLGPHPGVCVANLGSGDSSVLTLESEDKNSLTTAVSSLVCGVTVTTSTCVFFYVCNFSRLDFVNFVSFFFFFFFFAPPFPCRGRVFPRAWMQSISLTELHNNPHLPYLRTHTYIHTYIHKLGGDSGSGKRMQKQKKKKKKKKKVTMTEARENKERKRWSCYRMMMTNLFVSRDIPYETRGGEKRLQNGIKTLIRQPTERDKKRASAISAERAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KYR7</accession>
    <name>A0A367KYR7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_1361</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000062">
        <property type="protein sequence ID" value="RCI07336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KYR7"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI07336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="100" mass="11024" checksum="5D3CB878718EADBA" modified="2018-11-07" version="1">MSFGEPVSLASERRAYGSRTVVLPPTPFPSLLRLSFSLDDESLVLFIRFSRPRRAISASGLDGKMRRGVSVRADKGPPFPTQQMFVLGTAVPVVWHGAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZ38</accession>
    <name>A0A367KZ38_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_3779</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000029">
        <property type="protein sequence ID" value="RCI07434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZ38"/>
    <dbReference type="OrthoDB" id="4842715at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI07434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="87" mass="9868" checksum="E35A9117D89A4052" modified="2018-11-07" version="1" fragment="single">AGKSLEVLRTPRGYRLISLLNILTALIRSYLTSRSSRLKVDSRLSKPFDIERGSELLYFIRAYIANTSTLILDSSIIVPMQEAYMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZ57</accession>
    <name>A0A367KZ57_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450 monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_4572</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000028">
        <property type="protein sequence ID" value="RCI07463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZ57"/>
    <dbReference type="STRING" id="1330021.A0A367KZ57"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="437"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI07463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="493" mass="55597" checksum="D18BAE3BD16037AE" modified="2018-11-07" version="1">MPSSLLLVQAPIAFALFLGILLVELGRRRKSNIPTIRKWPALFPEILERLTYNRNAVDLVREGYSKYKDGPFRLLKMDMDLVVIPLKYASELRAVTSDKLDPLTASFDDNAGHLTKILLGSELHSDAIHRRLTPGLARIIPVVVDELRFAFDHVLMNHDPDSTTAVNPYDMVLDLSTRAAARIFVGEPICRDETFLQTTASYSRNSFSTIDTFRNLGSLVGLFGRAMSSTVTDAREQLAYVQRLLGSEVSRRRALPDEKHDDFLQWCMDLARTPDEALPESIAHRTLGILSMAVVHTTAMASTHMLFDLVSNPDLLEAVREEQRRILPGGWSTISQKAMLDMRLLDSLMRESQRFNPVGEFTFRRIVRKPITLSDGYRLYPGQQIAIPAKNLNRDEGVIPEADSWDPCRWATQKQASASFAHSSSANLHFGLGRYACPGRFFAAYMIKAIMSRLLLEYDIQLQNGSRHRPPNIISGDKILPNRDAVVLLRRHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZS0</accession>
    <name>A0A367KZS0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000024">
        <property type="protein sequence ID" value="RCI07666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZS0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI07666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="55" mass="6424" checksum="4E86C949A64DA590" modified="2018-11-07" version="1" fragment="single">NVTEVGIAQQRRRRLRLRHGYAVQRLRPYGPYRPTGQARRAFFSNTISLRVSIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZU7</accession>
    <name>A0A367KZU7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5675</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000024">
        <property type="protein sequence ID" value="RCI07698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZU7"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI07698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="84" mass="9932" checksum="355AA4378B3337E6" modified="2018-11-07" version="1" fragment="single">LPEPESLAKEYFWSLPIVAERGNFFKKSKEEGGKKEVEMDEELTNREEAIEEELEAGEVFVLRRYFSRYFKVPTCSTLTYLYPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1A8</accession>
    <name>A0A367L1A8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000022">
        <property type="protein sequence ID" value="RCI08002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1A8"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="183" mass="21085" checksum="5CA985D5910E8FE9" modified="2018-11-07" version="1">MCGCECECECEFWRYRRPPSLLGRFDSLEVSQPDLPPPPQKVPPTIPFPSPTRPDSRARETSSFRTDRRRFPKTRQPSASLPERDPRPLLIPAVPSPFVPLLLMLHPIPSHPIPSHPPPQRHATSSLSSSPPDPQRLTCRNSFPSFPPFRQRLIFRPYMHLHSSYTVVALIGYHYQALFHRHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1F1</accession>
    <name>A0A367L1F1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">L249_6325</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(6S)-5,6,7,8-tetrahydrofolate + formate + ATP = (6R)-10-formyltetrahydrofolate + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20221"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:195366"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1F1"/>
    <dbReference type="STRING" id="1330021.A0A367L1F1"/>
    <dbReference type="OrthoDB" id="5126881at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004329">
        <property type="term" value="F:formate-tetrahydrofolate ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004477">
        <property type="term" value="F:methenyltetrahydrofolate cyclohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004488">
        <property type="term" value="F:methylenetetrahydrofolate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009257">
        <property type="term" value="P:10-formyltetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046655">
        <property type="term" value="P:folic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006555">
        <property type="term" value="P:methionine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00477">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01080">
        <property type="entry name" value="NAD_bind_m-THF_DH_Cyclohyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000006">
        <property type="entry name" value="Bifunctional protein FolD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000245">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10860:FF:000005">
        <property type="entry name" value="C-1-tetrahydrofolate synthase, cytoplasmic, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001859">
        <property type="entry name" value="Formate--tetrahydrofolate ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.770:FF:000001">
        <property type="entry name" value="Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.410.10:FF:000001">
        <property type="entry name" value="Putative formate--tetrahydrofolate ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.410.10">
        <property type="entry name" value="Formyltetrahydrofolate synthetase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01543">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01576">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000559">
        <property type="entry name" value="Formate_THF_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020628">
        <property type="entry name" value="Formate_THF_ligase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000672">
        <property type="entry name" value="THF_DH/CycHdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020630">
        <property type="entry name" value="THF_DH/CycHdrlase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020867">
        <property type="entry name" value="THF_DH/CycHdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020631">
        <property type="entry name" value="THF_DH/CycHdrlase_NAD-bd_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099:SF5">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48099">
        <property type="entry name" value="C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01268">
        <property type="entry name" value="FTHFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00763">
        <property type="entry name" value="THF_DHG_CYH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02882">
        <property type="entry name" value="THF_DHG_CYH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00085">
        <property type="entry name" value="THFDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00721">
        <property type="entry name" value="FTHFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00722">
        <property type="entry name" value="FTHFS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00766">
        <property type="entry name" value="THF_DHG_CYH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00767">
        <property type="entry name" value="THF_DHG_CYH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="14" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase catalytic" evidence="16">
        <location>
            <begin position="6"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Tetrahydrofolate dehydrogenase/cyclohydrolase NAD(P)-binding" evidence="17">
        <location>
            <begin position="143"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RCI08227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="946" mass="100895" checksum="957DAEB64E3A3F6F" modified="2018-11-07" version="1">MVAMRLDGTAIARRIRESIAAEIVQRQQKNPRYRPFLKIIQVGDRSDSSTYVRMKLKAAQEAGVGCELLPFPESITEPELLHHIRRLNRDPAVNGILVQLPLPSHLSERTVTSAVAGDKDVDGFGTQDMGELAKRGGSPVFVPCTPKGVMHLLAEAGVDVAGKSAVVLGRSNIVGGPVSHLLRNADCTVTVCHSKTAGLQRHLADADIVVAAIGRPQFVKGEWLKEGAVVIDVGTNFVPDATKKTGQRLVGDVDFESASRVASSITPVPGGVGPMTVAMLLRNVVDATDRFFESQRRRHLVPLPLKLKSPVPSDSAISRAQTPKPITVVAEEAGIAPHELEPYGAYKAKVDLDLLARLDHRRDGRYVVVTGITPTPLGEGKSTTTIGLAQALGAHLGRLTFANVRQPSQGPTFGIKGGAAGGGYSQVTPMDEFNLHLTGDLHAVTAANNLLAAALESRMFHEQTQKDGPLYRRLVPVKDGTRRFTPAMLRRLAKLGIDKTDPDALTEDEIRRFARLDVDPETITWRRVLDVNDRHLRGVTVGTAATEKGHTRDTGFDISVASECMAILALSTSLADMRDRLSRMVVATSRGGDAVTCDDLGAAGALTALMRDAIKPNLMQTLEGTPVLVHAGPFANISIGQSSILADRLALKLVGTESDDDAPAGFVVTEAGFDFTMGGERFFNIKCRTSGLAPDVVVVVATVRALKVHGGGPPIAPGAPLDDVYKRENVDLVRAGCVNLRKHIANARSFGVPVVVAINRFATDSPAEVATVREEAQAAGARDAVLAEHWSQGGAGAVDLARAVVEAAEGKGEEDDKPRGKPRLTYPLQGNTVLERMEAIAKGLYGAEAVELSELARTKVDTYVRQGYGNLPICIAKTQYSLSHDPELKGAPTGFTVPIRDVRLAAGAGYLYALAADIQTMPGLPTAPGYMNIDVDCETGEIDGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1R6</accession>
    <name>A0A367L1R6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycolipid 2-alpha-mannosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_8897</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1R6"/>
    <dbReference type="STRING" id="1330021.A0A367L1R6"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF2">
        <property type="entry name" value="MANNOSYLTRANSFERASE KTR5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018153">
        <property type="entry name" value="Glyco_trans_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR018153-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI08380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="412" mass="48329" checksum="C675EF18A286901E" modified="2018-11-07" version="1">MVRLLRWRQPVWLRWRLLFGIALLVVLDVWTHRRRLAVTRPKTNLDPPFHVGCQEPVLNGSARAPAVLVMLARNSDLDGAVASVQSVQRQFNRHFAYPWVFLNDKPWEPNFVAVVTEAVAEDGSGAKASFETIPTGMWGYPDWIDQRKARSSMLRMQSRGVRYAGDESYHHMCRFQSGFFYDHPALRGYKWYWRVEPDISFTSAITYDPFVEMERHRKRYGYTMAMWEGDKTAPSLFHKLSRYKSERRLPGSALWTAMTSPSFLPWPLRRLRRFLPNHNSYGEPWNLCHFWSNFEIADMGFYRSAEYRRLFHFLDRDGGFYYERWGDAAVHSLAVAMLLRPEEVHHFSDVGYTHDTLQYCPYGPTAESLRRGELVPKMSDKMREELGCQSDCNTGARTIRPICFNRIKRTVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2C8</accession>
    <name>A0A367L2C8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_4693</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2C8"/>
    <dbReference type="STRING" id="1330021.A0A367L2C8"/>
    <dbReference type="OrthoDB" id="1922977at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="954"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="954"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="315"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="440"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="606"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="716"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="106"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="354"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="440"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="468"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="510"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="554"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="611"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="661"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="837"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="856"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="883"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="902"/>
            <end position="912"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI08590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1056" mass="112760" checksum="DADC557FDFE951EA" modified="2018-11-07" version="1">MSRSGGRGRDASRRFQPPPPRPQLQPGNTPNRNVAAAPGQGSTHNPPRNLIPGLGLGFSSGSPAQQGSPAVHASSAWFTAPPLPTEADAKNPTAAGGAGGERDSVSEEGEISEGTDDENLDINNPSRGHLVSTDSRKEAPGNAKQDSNRLTSRGRRTFAHTPPQVTASQSGSAKVARQRSGSYSPYLSPREMNSSHSPPGSHDRDLLGTLSSASNGISQLTANGGLVASPTQADFQLAKQKAKDAVLQLWSHNIRYQDYLNEGFDAAVVGGLFKELGLELAETANPLEEAKAQDISVEEAPVSREGPDVNVATARVAPQEPASERASKAADRSEERKDRIARLLALKGSKATVPASTPSHPTGSASTPASVKATPATQKAQSEKEKLLHQKIEALRKSRENLASLQYQQSDNANLANPDAEKSSAQYATATMIADAESRGFLERLSEAERPPGPDELSPPIPGLFLSTARQPSQSSDSNRPTPSLPDRSTRAFSRPFGQTASRPLLINVSDDDDDDDDDDDDAEMDIDSPARTSQDALPTPPQKTVAIREHASAANNAMSRQGHTPTSAATPPRNLNHGGGEDLASMNMRIEAMKRKIAEAEARKRIKLSEQASPAVSQQNDGSRAVSVEMGSVPSDPGAPIASSPERNGTPVAATLTAEPPHERPPRPADTGPDRSSGRQRRSVTASERLPFIEAHRKEQLLKLKSLQSEMARVEQEIAQSMQEEEKLKQDLAASDSDEQEPQERTLAEASPSGCVQQRGEKAVISGQDTDGDTEMGSKMSGLGAAKTARDDVKAGTEANAAYSITDTTDEYMTGPAHESNEEADGDVIMEGSDIGTGQDSGDSTDNYEPPDAESDGKDTLTRPDEEAPQNETSAAIEAAGNGSTAVSIVRTTSERGKETMPQSVSTTSGASDGRFVPYETPLQCFRAYRFHPEFGKRVEGGLRSLTYSNKIDVQKQLCPDELAGQPCPRGGQCDYQHFESMRAPDDQILLQLGAAGHYQESQRQQYIAGLRELLTDLRNRKVKDFNTISQGIIDYRARFLGDASKILPLSGVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2W7</accession>
    <name>A0A367L2W7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_4723</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2W7"/>
    <dbReference type="OrthoDB" id="4925822at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017025307" description="Transmembrane protein" evidence="2">
        <location>
            <begin position="33"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI08747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="136" mass="15257" checksum="69B1C09C321C2D6B" modified="2018-11-07" version="1">MKLPQPPSLIPISISLLTLALALTLNLSVTLAIPTPNHQVTILVPMRLLDNKLVPDTESRPVLLPDSNSIIDDHLPPLVWNPDSSRLFLYSMTPERRPLAVVVILLWVLATCWYFLRPYDSDDEEEEDGEQGGVHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L377</accession>
    <name>A0A367L377_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5015</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI08874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L377"/>
    <dbReference type="STRING" id="1330021.A0A367L377"/>
    <dbReference type="OrthoDB" id="4814848at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="475" mass="50665" checksum="54B7D65CC9CA79BB" modified="2018-11-07" version="1" fragment="single">MDLTEHELLFFAEWPASASPNSQAQPPDVTPPRQPLGGGRHSPMLLGGFVEPGSSAMSFSPHLGWDDSPLAYRQAHAPNLLQQTNQLAHFHDSPVPLGAPFGPRSSSIFGPAPGLESAGSKERPLAFPLPSAWNQVSPDNSSTVPLGEETRSGDIVGTSAPSVPEACPGAEDVAGHSTWSSPADNIPCTPCAPGQDQESVEKKLRSFSQPQHQRIRKPRISGEGLNPHETILAEQSALPQTRRFPGLFSNADAANRAMGDLQNVLRMPKADYTTPADDATFPATDADMVAVVASVFDAISDWSHVTEWKNTLPRSERARITETLVSRSSGGLDVSHSNSEGLRPSDSELADMLPSLEMQQKKILGQVPSDQAVECISWGIVQAAIKSQQGFTQVPYWCEQDGTSKQLVKSLLTAGDGWRLRIVNAPTKEFQAKAKNRRANSKRPGLQGNFSGGSGSGGSGSTEGDSPFLGRARSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3H3</accession>
    <name>A0A367L3H3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pali-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_5031</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI08974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3H3"/>
    <dbReference type="STRING" id="1330021.A0A367L3H3"/>
    <dbReference type="OrthoDB" id="2354757at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035838">
        <property type="term" value="C:growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051380">
        <property type="entry name" value="pH-response_reg_palI/RIM9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013:SF7">
        <property type="entry name" value="PALI-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI08974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="237" mass="25396" checksum="67BF5C9FD28CD98D" modified="2018-11-07" version="1">MGFGTFVHHIGTLLLLVATVLLIVVDVTAPVVDYLAIMRVDLGPRVQGSSVTFGSFGYCHRGLRGDTDECSRRHIGYNPAGVMHDIDGTDFSSAAENTSKGLTRVMILHPVATGLCFVAFLLCLGSGIIGSVLASVFSLLAFIVTVVAMACDFVAFGIIKHDVNGYGRSRAHWASGIWCVLAAAIFTLVATLVILLTCCAGRAKKRREAAHGQKESSTLDPSARQPFWKRPPFKRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3I4</accession>
    <name>A0A367L3I4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">O-methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_5051</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI08967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3I4"/>
    <dbReference type="STRING" id="1330021.A0A367L3I4"/>
    <dbReference type="OrthoDB" id="10251242at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050362">
        <property type="entry name" value="Cation-dep_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509:SF14">
        <property type="entry name" value="CAFFEOYL-COA O-METHYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509">
        <property type="entry name" value="O-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI08967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="26311" checksum="F16497075C5C04EA" modified="2018-11-07" version="1">MDKLRINTRNTDRCNKVLEYAYKHSTALPAPLTSYHSEAVASRDDSAMLSSNAQSQLHGFLARAVGARNVLEVGVYVGYSAMAWAYAVGSAGTVTGLEVDEGLAGIARGAFAERGLGNVEVVVGNAAETLPKLKPSEPYDIVFLDADKPGYIGYLDTLLGQSLPGSRWRLLRPGALIIADNVLRSGHVADDSLPFDDSRSDESWRSHIDAIRAFNDRCVAEARLETFMLPLWDGVSLLRLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3U5</accession>
    <name>A0A367L3U5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5062</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI09087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3U5"/>
    <dbReference type="STRING" id="1330021.A0A367L3U5"/>
    <dbReference type="OrthoDB" id="5388486at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039970">
        <property type="entry name" value="TF_Grauzone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23225:SF2">
        <property type="entry name" value="AT09679P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23225">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="308" mass="32124" checksum="18ECDBFF6EDAF9C7" modified="2018-11-07" version="1">MSSSSSWISASSWAAALGTVSISSSVNSRNSTTKSNQLTPSSSGSTKNSHGHGHSRGRGPVVSREFPGKNEWKRHVNTIHVREEAWVCVQGSCASLATAASASASASASTSASSTSASSSSLPPKGRIFNRKDLYISHTLRAHKHLLPSSSSSSSSSSSSSSSTSSSSSSSPSTTATTSTRPSSSSSSTTTTTTTTTTTKKSEQQSLASLSHHKRLSLPTNLSCPLPHCAEAFVGTAAWDSYLEHAAHHLKTSLGTGKRAVESLVGSWMADEALVRFGFDAGFLSLDSKHHGLDRNINNCVALYCTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4C8</accession>
    <name>A0A367L4C8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_1470</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4C8"/>
    <dbReference type="STRING" id="1330021.A0A367L4C8"/>
    <dbReference type="OrthoDB" id="197068at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08199">
        <property type="entry name" value="EEVS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1090.10:FF:000015">
        <property type="entry name" value="3-dehydroquinate synthase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000018">
        <property type="entry name" value="Related to 2-epi-5-epi-valiolone synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050071">
        <property type="entry name" value="Dehydroquinate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056179">
        <property type="entry name" value="DHQS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035872">
        <property type="entry name" value="EEVS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43622:SF3">
        <property type="entry name" value="2-EPI-5-EPI-VALIOLONE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43622">
        <property type="entry name" value="3-DEHYDROQUINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24621">
        <property type="entry name" value="DHQS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-dehydroquinate synthase N-terminal" evidence="6">
        <location>
            <begin position="85"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="3-dehydroquinate synthase C-terminal" evidence="7">
        <location>
            <begin position="195"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI09286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="443" mass="48630" checksum="EA0B4971762D4A7B" modified="2018-11-07" version="1">MSDMKATVEQTSNGFSVRGYEKIEYDFEFLDGVFEARNSQLADCYRPWGRCLAVMDLNIYVLYGHLMRRYFEAHDIALSVHKTAIGEKAKSVETLLSIVDSMDRFGVVRKEPVLVGRGGLVTDVAGFACAAYRRTTNYIRIPTTVIGLIDAAVSIKVAVNYGRCKNRLGAYHAPIHTFLDFTFLRTLPTAQIRNGFAELIKISSCADADTFDLLDAHCEHLICSAFARADGSDSGLKEVADRICRAGIYEMLRLETPNLHELMLDRVIAYGHTWSPIFELVPEPHLRHGHAISIDMAYSATLAHRRGLLSGPEHRRLLRLFSRAGLAMDHAGFDAAILDRATAAILKTRDGLLRAPVPVSPIGRCVFLNDVSGEEMRAALEEHKRLVASFPRRGEGVDAFVDASDTGYTAVQQPADVVVTTLGKTGRAAAEVSVSAVVTNGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4F0</accession>
    <name>A0A367L4F0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ras-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_1550</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4F0"/>
    <dbReference type="STRING" id="1330021.A0A367L4F0"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000654">
        <property type="entry name" value="Small g-protein ras2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="191"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="219"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI09306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="239" mass="26539" checksum="FF8E7304B7017354" modified="2018-11-07" version="1">MAGRMVLYKLVVLGDGGVGKTALTIQLCLQHFVETYDPTIEDSYRKQVVIDNQPCMLEVLDTAGQEEYTALRDQWIRDGEGFVLVYSISSRSSFTRIRRFHSQIQRVKDSCASSPSYPGSPLSAATQQMPVPVMLVGNKSDRVTEREVSTQEGHAMARDLGCEFVEASAKNCINVEKAFYDVVRILRRQRQQVARPPAGSGGRSRTSGNGDVGPGPGREFSRYRRSKDGERAKSRCVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4I1</accession>
    <name>A0A367L4I1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_1417</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4I1"/>
    <dbReference type="OrthoDB" id="4074965at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39608">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G08640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39608:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G08640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="6">
        <location>
            <begin position="8"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI09330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="154" mass="16991" checksum="5ED6EFCEF99EA317" modified="2018-11-07" version="1">MSALDRIVSLILRAAEVAFAIIVAAVTGYYLHGSNSSAWSLGRYIYTEVVAGISILLGLLWLLPFASTFSHWPADIFISLLWWASFALLVNATGSSCGAIFNWQNVAFTGEDQCGRFKADIAFAFLSAVLWLASALVGLFWTGRHERRVRRSRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L510</accession>
    <name>A0A367L510_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2415 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_4086</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L510"/>
    <dbReference type="STRING" id="1330021.A0A367L510"/>
    <dbReference type="OrthoDB" id="64353at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019417">
        <property type="entry name" value="DUF2415"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991:SF9">
        <property type="entry name" value="DUF2415 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_8G05640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10313">
        <property type="entry name" value="DUF2415"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2415" evidence="2">
        <location>
            <begin position="379"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="250"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="491"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI09509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="701" mass="77720" checksum="44154AAF951D1980" modified="2018-11-07" version="1">MAAHDDASPYPTNAIVSKKARKHYRVPVRSQHWQLRSLISAQKRHLVYFPGGNGSNHVQRLDTLTHECETIKLLTFAPRCLAVRDGWLCCGSETGEFVAIRLDDDAVESASRLELNADLRRHFGLDGLHDESLMSLLATRQSNKSLIAKGVKLAKDRVNCVTIWSPPTLFSAAPDAYAEPVAVLANNDRTVIIVSLRDFERGEKTDPLEVVTYPDFVNRAIISPDGRLLIAILDDPYLYVHERTPQNPDSSSSSSSSSSTSSTDAGVALQWELRQKFLLKSQRKDDRSDSRGSFAACFSSSGAYLAVGTQHGTVSIFDTTLLALADGEPLITTFTSSPYLAVGTQHGTVSIFDTTLLALADGEPLITTFTSSRPESGPGAVRDMAFCPGPFDILAWTEDRGHIGFADMRSNFVMRQIIDINAEADFEHIDILDRNTIDPRLLSSNGEWRSGRSASSRRRNGEGLDTLNQPLTADETLVLEAIRSDRRRRERLSQRGVEEGSRRPDLSWTYRPTANDGDSSQRPREPSSSVGRTSGHLESAYREARASGNAQHPEWVRAARQVAREAGGQQRQSTRRPEQRLMERIGETFAAIRDQRERTDSTYLNVFDILQGRERSPAEQDDPSLLAPLVNQAMNRWEESAIRGTLVSDHGVFEVPPSPDNTAGLAWTADGRTLYIGAQNGIYELHVNVQSRKFCPSITMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L553</accession>
    <name>A0A367L553_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_3742</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SGT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000015">
        <property type="protein sequence ID" value="RCI09352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L553"/>
    <dbReference type="STRING" id="1330021.A0A367L553"/>
    <dbReference type="OrthoDB" id="1898560at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06466">
        <property type="entry name" value="p23_CS_SGT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007699">
        <property type="entry name" value="SGS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044563">
        <property type="entry name" value="Sgt1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45862">
        <property type="entry name" value="PROTEIN SGT1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05002">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51048">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="4">
        <location>
            <begin position="229"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="SGS" evidence="3">
        <location>
            <begin position="378"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="321"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="430"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="374"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="430"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI09352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="463" mass="52473" checksum="52782B6FA2303754" modified="2018-11-07" version="1">MSHITLAREGLEAVKQRRWDEAVTKLTTAVKGSPNPTWIVARSKAMIGLQRHEDALHDAELAWHYAYQRSSRSDLMDSQFRRGVAYYHLGQFANADCCCFYAMRMAKGYPAVEDDDPKLPWVDEQGHWTVGVQKMKELSQTDPFNIGHTSPNHSKDIPFPFMNQAQGPHILAWRRTSLFRLQILRAMEALPEEDEARLVKVNQVPSRKPYDKYNTLPPLAAAGEQADASAEPRMQEFQTPKTITVSIFSKGIDESKFTVDFQPSYVRLQPVVYPDGSSRPMHLSLWADIDPSCSRYFVTPCKVELQLYKEGVGKWPQLTKDEAQPADEASDPKSNVTDGVAKKNSHSTYSNSDKNMVRRNYNNKRSRLQKEKQTSGPSYPTSSRSGPKDWDKIASGNGADEDDDPDVNAFFKKLYENATLEQRRAMMKSFTESNGTSLSTDWNDVKGRKVETVPPEGMEAKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5N9</accession>
    <name>A0A367L5N9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cns1/TTC4 wheel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_4117</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TTC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5N9"/>
    <dbReference type="STRING" id="1330021.A0A367L5N9"/>
    <dbReference type="OrthoDB" id="420195at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044059">
        <property type="entry name" value="Csn1/TTC4_wheel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18972">
        <property type="entry name" value="Wheel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Cns1/TTC4 wheel" evidence="4">
        <location>
            <begin position="255"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI09731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="357" mass="38530" checksum="C2DEF935063AB841" modified="2018-11-07" version="1">MDADTKPALPPAMASAAGKTVDEVWADLNKSPLFMTEMEENDDTAALQALSYEGTPLENAADFKERGNECFRVRGYVDAREFYAKGVAVLTTTTTAADKRHDDDDDDDDNDEEKATMLEALYVNRAACNLELENYRSCYLDCAAALRLNPHNVKAYYRAARALLAVDRVRDAAEACAAGLVLDPDNGSLRAASAAVVGRKDALDAIARRRSARVDEAARRARLVAAALAARNVPPLRTSDRPPDADGLGIALVPDPDDPRSALAFPAVLLYPLRLESDVIKAFVETESLADHLQYVLPPPWDGEGEYGAAADVSCYVETRSGGLLKMGKRVPLLKVLATGQADGWVAEFKAQRTAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5R9</accession>
    <name>A0A367L5R9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5R9"/>
    <dbReference type="STRING" id="1330021.A0A367L5R9"/>
    <dbReference type="OrthoDB" id="1749473at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="646"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="674"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="696" mass="75658" checksum="EFBA3DACA501AD28" modified="2018-11-07" version="1">MAHAAADHLRPHSDQPPSSKLSRRESRLGIKNIFARSKPTKEEQRSSGIRSSLADLGQWPHGHHSDAALSSSPPWDNPHPDPVMDRDHRTERKGPSKPAPKRPVINCTTLPLCKAFPQAVRHVALPAATISADAILRINERKHPTSLVDEAVQSLSRDRRKHRRNNSASAEKLEWTTKIFVLVASGHLLQYAGDGHFDRLPEKTLRLGPSSVAFATDAIPGRHWVVQVSSSTADASSPTETRSISILSKLPFRTDRRSTSNLLMVFESADVMEAWISALRTEVEKLGGKKNLSETGRPRTTESVQSPAQQWHGRPNLAADDASRLHRSNRRRTREVRSSEVLTTSPVATVEDDSASNSGLSQDEHQLDSLREHSQRYSVISSGQRTVLTSVGPSPEASPTREQVDELSGRRGEAAARPRPNGCEIAVRRQSSMQIAGTFIDADRTGSHSPSIYRGDGVASPTGLYPTPNFSVPQSSNRRYSHARMPLVDIDALLPLDRAGEPSPALTRSKQPPLAARTTHTLSVVMDQPLAPPLLEPPSPQRPATGHGGTRSPAKRSSRQRPRSTSRGREASPTRWSPDGALSGGGHDDNDAAAAPSPSLTPGYGRNRRSRDAQSMPPSATPDPVMLVEPPSRPRRLTASPARIQAHSSSPHLKAQMTEQALFNRRSMPQLLAGPPPAPPPTKALPPIPQNLRGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5S3</accession>
    <name>A0A367L5S3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5S3"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="86" mass="9882" checksum="0CEB4277E7510F4D" modified="2018-11-07" version="1">MPRLCLSDQPFSSRTVAAEWFFNYYDSRMAQEALLFEGHASCCTYVRTTGGVEEALPPLMAEREKTERNETRRRNMNTWGGRGAPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L630</accession>
    <name>A0A367L630_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cyclin-dependent kinase</fullName>
            <ecNumber evidence="1">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_3860</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="1"/>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L630"/>
    <dbReference type="STRING" id="1330021.A0A367L630"/>
    <dbReference type="OrthoDB" id="413582at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF576">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CSK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="85"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI09877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="373" mass="40460" checksum="33FE3B20AC961E59" modified="2018-11-07" version="1">MSPSPAWTSSLSAVDRYEAIRSIQASRPAADAVALERRAYEDSASRDEYNAACSRAAGSNNQSASQNAVPQSPPSPLGSIRIGPYNDCVFVAEGVTSRVYRSGDYALKVIVAHAPLEPHSPQREVKILQRLHPPCIPLLDVFRDQEQRLVLKFPLMPMTLAGLLAAGQPSSTQLRAIFTDTLRALEAIHADGIVHRDLKPSAILLASPAGPAFLSDFGTAWHPSLSPPSEPANAKILDIGTGAYRAPEVLFAHRGYGPPVDMWGMGVMLAEALRSPPCPPFESRSVDEDGNQLGLILSIFKTLGTPTPETWPEARDFVVSPFELWTVFPPRSWPEILPDVDALFRDLVAALVRYDGHRASATEVSRRLSASNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-05-03" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6B5</accession>
    <name>A0A367L6B5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_8753</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI09975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6B5"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI09975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="57" mass="6657" checksum="BDD2286CAEB60F3B" modified="2018-11-07" version="1" fragment="single">REEEEESRDSLKEAIEEELEAGEVFVLRRYFSRYFKVPTCSTLTYLYRCAQGGVGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6J5</accession>
    <name>A0A367L6J5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_8732</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6J5"/>
    <dbReference type="OrthoDB" id="4927425at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="3">
        <location>
            <begin position="396"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI10029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="886" mass="99563" checksum="7A324CCCE45B7361" modified="2018-11-07" version="1">MSDPRRYTIGWISAILEEFVAAQGLFDEKHEQRFMQRTNDDNQYALGKIGNHNVVMAVFPIGHSGVAAATMAAKDMVHTFSNVRVCLMVGIGGGVPSAKHDIRLGDVIVSAPSYSPTSGNHGGVVQYSFKETMEKRSFQSVHYLQQPPRALLAALTALQARYMGEGNNIDVMVEKVLEKNPRLRKDYAKPDPSTDKLYSSEDGSLIERRERTKYEDNPAVYNGLIASADAFMENAQVRDLLAKELGVLCFEMEAAGLMNTFPCMVIRGISDYADGRGESSDWRGYAAMAAAAVAKDLLSMLAPRQVEAEESIAEAVGKSLFSNLEIMAGSTNTMMMEIRHAVVDADQQIVLNRLSVVKEASFDSKDEESLCQCLEDTRVELLQKIMGWAREPNSRPILWLQGMAGTGKSTISRSIAQQLHDADMLGASFFFKRGEKDRDNTAHLLTTIAFQLAARRPIIGRHIKSAIEDDNSICDKGLKVQFEKLLRGPLSKAARSMKPLVVVVDALDECEKEETRLVDKVQMILNLFSSLDKSCGLRTFITSRPEWPVNRPFSHIEGRYQTLILQKITDPVIEHDIDIYFNHKLATIRDEYNFNPPGGEKLPPGWPGTKNIQRLVKMATPLFIFASTVCLFVGDGLPLALPEENLQRVLEYETQSREFRLDPTYKPVLDRLLANRTTEDREKIVERFHNIVGSIVVLASPLSVIALSHLLSVDRRIINSQLHTLHSVLSVPSNNSVPVRLLHLSFRDFLVYPRRSCDEPFQVDEELVHSRLAGHCLRVMKETLRRDICGLSLRGLEGSMPGREEVERHIPAEVQYSCLNWMFHLQGSKERAPDHFNSVYVVLQQHLLHWVEALSLLRRFAESISMLMSLKNLVQVRQSAVYSDNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6K7</accession>
    <name>A0A367L6K7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_8717</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWF19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367L6K7"/>
    <dbReference type="OrthoDB" id="276515at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040194">
        <property type="entry name" value="Cwf19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006767">
        <property type="entry name" value="Cwf19-like_C_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072">
        <property type="entry name" value="CWF19, CELL CYCLE CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072:SF5">
        <property type="entry name" value="CWF19-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04676">
        <property type="entry name" value="CwfJ_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="3">
        <location>
            <begin position="414"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="Cwf19-like protein C-terminal" evidence="4">
        <location>
            <begin position="1309"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="74"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="347"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="771"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="997"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1081"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1190"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1420"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="771"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="782"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="798"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="998"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1010"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1113"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1191"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1430"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI10054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1455" mass="161857" checksum="568656FA29162B1A" modified="2018-11-07" version="1" fragment="single">ISHPSVKVKYESDPAAPCAHHRCSNAVPVGGRQPETARYSEDPLLCVVCFRALDHNSLVPQRPLHDLGLVLLSQRSGPRPSKPGLREYRTRPAAAATQQRGHSRPPYTLEHLRGGGGGQELFQGPLLSPGVKPLSTTQSHPAITPTKAIITIERTAYRAQRSPSNEIQKALTSFIIIIIIKAKFKMRLLHTSFFPLITAALLFLGKTAAAPDGSLSWSNGEPLFTFNYSTPNPDPKNWVGLYNSFYGGPDNGSYVANSLAWAYAPQGDGSVRVPPPDSLPPGTYKAFFLAKDGYEHLTDPVDVIMPGNGPLSFLVDEFTTRNGRQGDAFNANVKGLITNQRDTSTKFAKKASDGDGGDWVQVSEDGSLSGTPDASGEKRVTVEATGSDGAKAQLQVKIPVREKGSPLVDRIGVLSFNMWHGGTQVNDYHRKQVKYLAGSNVDIVGLQESNDGQAIRLGQALGWDSWQGRDVGIISRYPMVERFNATQAAGAVRIALDGDASQVIAWNAHLGYTPYGPYDFCFDNMTVDAVMQREKESGRTPQILEIMDRMKPQLANTDSLPVLLTGDMNAPSHLDWTDATREQHCGVGAVAWPSSEEPTKGGLVDSYREIHKDPVADPGITWSPIYLTNEGRPEPMDRIDFVYHKGLDVVDSVHEVVGQPRAEPDHKDNEWTSDHAAVRSTFQVPAKQKKREVVREMLRLYIDSVVESARVTSRRLSRAARSIGRVGSSLTASAMIFPPSSVSIHHALHRSLRISHIMDGLDEFERTLAAEKATRESTERRHDKHRHHHRRRHDDDDERYRGEDADRRRRHRRRREKPADEDEDERHRHKRSRRSDDKDGEPPLVRDAWMTAPSAVAVEHMHRPKRPPAAASPQRVIHSRELNRSLNKPEAEKLSRSAVAAAAAAADDDDRDHYTFGDDGSSWRITKLKAVYAAAKESGRPVEELALDKYGSLAEFDDAREEQLELERRTLYGEGYKQCERPTGKLYRDRVQSIPAAVDDEDDQLEPDDDDHHPGHEQRRTKPSVDHTSLNRLRAQMMKAKLRGAPDAAKLEAEYNRAAAEAEAASSDPAVVILDAAHSRHLAGRGKEVQPSSSRRRRSRGALSDNEEMTVEDMVREERRTRHDGNTSSARRQAERIARDGRFTDGLDYLDDNAARLARGVHRSDAAMRAAAAADTQRMARALDRCQLCREDDDDDDDDDDDNDNDARRRRGHRAPVVSLATRVFLTVAPDPEVTPGGAVIAPPIPPCYPPRILTRMYHDQGRDVIFYENASSPSPDRHAAMVAVPIPYDRGGLAPAFFREAILSAAPEWSVHAKIIDTTARGGLRRSLPRSLPAYFHAWLGGIDGGLAHVIEEPRSWPSGDRFAREVIAAVVGEDVEPGLARRRARWGAGDEQRRVDGFRKRWRPFDWTRLLVEGEGEKRDAVMLSMPKKHEPDSSLRHGHEPPSNPDFHRQNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6M4</accession>
    <name>A0A367L6M4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inclusion body clearance protein IML2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Inclusion body clearance protein iml2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_8758</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Inclusion body (IB) resident protein that interacts strongly with lipid droplet (LD) proteins. Involved in LD-mediated IB clearing after protein folding stress, probably by enabling access to the IBs of an LD-stored soluble sterol derivative that acts as a chaperone in inclusion clearing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with lipid droplet proteins.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6M4"/>
    <dbReference type="OrthoDB" id="2154985at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019412">
        <property type="entry name" value="IML2/TPR_39"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10300">
        <property type="entry name" value="Iml2-TPR_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="190"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="197"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00043897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI10077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="693" mass="75624" checksum="9F991E51D7108467" modified="2018-11-07" version="1">MPLISWFRSGGDDGSKVDDVAAAAAAAAAAATAKHHADLADALRWLGIMMNDDLDRALDELRKGDSCFHDFGSAIALFLRAMLGLEKAVLAETATALAELETRAWNDAKAAQRAAASTSSVANARRRVYPPGTEYDLIRAEAQLMGAVLGVLQESIVEAMRGFYKLRRAYVVLEGIVDIEVKARATPAAAEGEGGEAESSSGADSSSGVDSAGRSAARTDRSSAATTPEPAELTETGSGTTTKHKSGDDDVLDLDDPVDDFIHGSANTSFGLVLLLLSLTPPAFSRILSAVGFRGDRERGVHLLWRSSSREDISGVFSGMLLLGFYNVLVGSVDIMPDEQDSKGDREAEALGPPRARCRRLLAEMRARYPQSQLWRIEEARMLAGQRRLSDAMALLRSGPEPKMKQVAALSAFELGVSAMAAQDWVLARDTFMHCVEISNWSPAMYDYMAGCASLELYRDGGPDAAQHKRQAEKLLRRAPVTAGRKRLLARQLPVEVFLQRRVRGWDARATSLGVDLADAVGPSPGMEMCYVWNAQRRMSDEELRRAEVLLGWERCHQGAVVEAIRADRSEVAVWAVNTAAVLRAQGRLEEAREVLGREVLAYDGSEFKGTHKVDYALPATTCELSAIAWDECCRATTAEERRAKLDECEAELQRADEWEAFSLEARLGMRIQAGRQTVEWLRKKMGWKKGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6T1</accession>
    <name>A0A367L6T1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Presequence translocated-associated motor subunit PAM17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_8606</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the PAM complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the PAM17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6T1"/>
    <dbReference type="STRING" id="1330021.A0A367L6T1"/>
    <dbReference type="OrthoDB" id="5970083at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013875">
        <property type="entry name" value="Pam17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28021">
        <property type="entry name" value="PRESEQUENCE TRANSLOCATED-ASSOCIATED MOTOR SUBUNIT PAM17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28021:SF1">
        <property type="entry name" value="PRESEQUENCE TRANSLOCATED-ASSOCIATED MOTOR SUBUNIT PAM17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08566">
        <property type="entry name" value="Pam17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9 12" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="117"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI10135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="214" mass="23749" checksum="AF4E8080C86BA28E" modified="2018-11-07" version="1">MASALRTVASRQHAPSCFAPCRRLRHGRLSLPIEPLRRLVSSVSPQTTTASKPTVSFTPYPKPALDWNSFFLLRLRRRRVQVTFSLAGFVACGVGGAYIISTGIAEPLVAQIPLDPIFTLGLIGAACAGLGWLAGPSIGNQVFYLLNYPFKSQMIRKESEFFTRIKRNRVDPSNSSAGNPVPDFYGERIQSVAGYRQWLKDQRAFNRKKTANFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6Z9</accession>
    <name>A0A367L6Z9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_8689</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367L6Z9"/>
    <dbReference type="OrthoDB" id="4927459at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF50">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="440"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="977"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1010"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1049"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1082"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1128"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1161"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1194"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1227"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1260"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1290"/>
            <end position="1322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI10206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1333" mass="147942" checksum="84122CE24839E93C" modified="2018-11-07" version="1">MKPRNRRRFHRGDDDNDDDNDDDDDDDGNADGTAEPRPFQPQKRPRNLHYDPSIAWPSLALPALPPSPALPAFSRDQYTIAWICALHIELAAARSMMDVFHEYLPDEPLQIIDTNSYTLASIGHHNIVMACLPAAQFGTNNAAIVATHLRRTFPSIRLTLMVGIGGGVPSMDDVRLGDVVVGLRVMQYDAGKIVDDGKLQTTETWRHPSQSLLTAVSNLRSKHEFEPSRIPIILRHKLKTQPGFLRPSLPDHLFRASYPHQSSTPSCDDCDLDKLVPRRSRASDDPVIYYGGIGSSNQVMRSATYRDSTARRLDVRCFEMEAAGMMDILHCLPIRGICDYSDSHKSKGWQRYAAATAAAYAREFIENLAPTQTHTKSAPWPVPSGLRSLQLEKYMSVSDVPAASDPESISKVRRKLLLESLRFDQMDSRKLTIKKAYNKTCRWFLSHPSYLEWLDSEQLATHHGFLWIRGKPGTGKSTLMKFAYSRLEVETRHQLKASFFFNARGQDLEKSIAGMYRSLLLQLLEGFPDLQEVFDDPELISPDQCDCPSLHILKNLLSGALSRLGERSFTCFVDALDECDEQHVMDMVQYFEEVAEDSTENGIKLRICFSSRHYPYINVEKGIQLVLENQEDHAADLDSYVRTRLDIKVGAAAEELRSKIVEKAAGVFLWVALVVDILNTEHRQGGMALKKRLGEVPSGLSELFRDILARDKQNMEQLLLCILWILLAKRPLEPREYYHAIWSGLSLQGLADAEIPDATPSVVASCVISSSKGLAEVTKSEEPTVQFIHESIRDFLIKDKGIHDLWPDVGFDWESPGHEKLKLCSMTYIKHPSMYASVMSADVKVLLDYPFLRYASQHVLSHADAAAVAISQDDFLSQLSLSEWTTLLKTAETERYGLDPSFLYIVAEKGLPRLIRSTLKQGTRYKIQGGKHVYPLFAAFNSGIKDAVAAVLGLSTCFHNGVDVTDLPRSRKGEGFNDRTPLSWAAEHGRVELADLLLRKGELVNEVDGTGYTPLLRALNRFVMESSHDATVTLLIEKGADVNARNRITGETALQFASIFGRMAMAELLLEKGADSNARDLRKRTALHVASLGKAARPGGLDCPDPNSEAIARLLLDHGADVDAYDESGLTPLYLASSHGCAAVAKLLIERGAHVDAHDEYASTALHLASFEGHEAVAELLIRSKADLDAYDMSNRTPLAIASMEGREAVVKLLIEKGADVHACSMSGRTALHYASEKGHEATVKLLVDRGADVNAYNHSKQTALHLASMKGWKAVVKLLVDRGADVNAKGESPLYLAIVHRRGAIAKLLVENGAGVDQTIRQRALERGIALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L712</accession>
    <name>A0A367L712_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_8680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L712"/>
    <dbReference type="OrthoDB" id="4924119at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI10199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="212" mass="23333" checksum="786333EA618D13F6" modified="2018-11-07" version="1">MKCLTYSHMGGIPSCYYYNLGLQVVTTQLNSSNTHQGRRLSTQLRTRMTSKVPNSCPCSRRGYKSSKEAHLRNYIQLSAPKHQRLKMQSPPSVKGITLALVFTASSSLFTTATSQPVSTESSSQQTTIEKRSLDGCRLTVSVLAPGDLTMDFANRFGADPENVRTPDMARSVQLMKDAIADGDQVRAHDALYTNCQASVRDDASKHNTGRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L717</accession>
    <name>A0A367L717_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_8727</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L717"/>
    <dbReference type="OrthoDB" id="4907280at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI10226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="429" mass="47699" checksum="D7F4866B6BC44ABF" modified="2018-11-07" version="1" fragment="single">PGACLHRPPPVRNNSSALGVYFINLAISPYQSCNPVRTCTQISHDTTSASSQKGNKEKMKAGFLSLLGIFAFGVLGTTASEFTSLDNCTALNPGSKYANFPDQTPETVKKIINECRKCRQRGICKDPALRDDLDYDHFCGCLAQMRPRPVFVIASGVTNQERVSWALKHGANALELGVGPRGLFFNEWYTLPSKAKSTMWADQATSVISFIAQKVKEGHHVAFVWLEICWPDYCDVAKEEEDSCSLVGLMKLVREHLTPLKVPVLFSFYEVGNMKALNYTRDNLGPLDALSTPGTAVDSINLFKGGKLPKPRQRIMSHAFWREEDDTQEWEDELTAGVRSQAFNKVFTWINTENDDYQGVLGPALASGVDGIAYGFEQRSYQDWPPFRIAIGEVKSAIYDNPLTRLARRGDKPWIKQSMGKALSVLVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7J3</accession>
    <name>A0A367L7J3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4384</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7J3"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="76" mass="8545" checksum="DD086499513CCC8F" modified="2018-11-07" version="1" fragment="single">SRRTQKGRKKDARAHTKEHTQKSTHAQKERGRQTTPVGLVLSSVSLVLNLPEPFRSMSSLLLFISCPCPQSEVLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7Z0</accession>
    <name>A0A367L7Z0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pentatricopeptide repeat-containing protein-mitochondrial domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_4282</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7Z0"/>
    <dbReference type="STRING" id="1330021.A0A367L7Z0"/>
    <dbReference type="OrthoDB" id="747253at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057027">
        <property type="entry name" value="TPR_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF17">
        <property type="entry name" value="OS12G0638900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23276">
        <property type="entry name" value="TPR_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Pentatricopeptide repeat-containing protein-mitochondrial" evidence="2">
        <location>
            <begin position="312"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI10535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="587" mass="64965" checksum="1B969AB770177F49" modified="2018-11-07" version="1">MHSGRLASVCIWRCLLTRPSTLRSRHATVRPPKAGSQLGLCQTRFHGAVSSELRAEEPVEGGHSWEERLLGQTSPAEAALSQSTVEELTMALMAMRNLREWSPAAGHDFDRHGRIIQMVQHMIRARCQTPNIFMYECLMDAMADPEGSAIGVRKLLLDMKAQKVKPSAAVFHSALAALANHPDYMLRQDVLTLMSEHWVLVDTAAQQNVVVGLLREEQYELAYARLTRMMEQGVHVDCWVYDLFIMAFGKLGFLDEMMVLLHQRGLVEGASDQVLNTLLYFVLDVCSESFHLDGTVFAWKAVVSTSKVQPPDGIVDNVMATAARHGKPALAIEALDLLSKRSWVQARHYETVVEAFAAAGDIAGALRILCIMRKHGRQKSTVIKRDHTRPIKQAMLRDPKKLVAEAERAVRSLAKDEAVSPALVGVVVEAQAEVFGSEAALSLYKDMASLSASPPDALTMQTLIVHCKSHETRRSIARDYASAVSPDADPPRNAVVYCELISACAAAGEMDLAFRFAAKAVPLCRSRRQISWFKPLMVAAVATHDDRIWAVVDEMLLRGGHVGATVQIIMQQSRMAKQFSDRQRGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L812</accession>
    <name>A0A367L812_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L812"/>
    <dbReference type="OrthoDB" id="4927418at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="91" mass="9830" checksum="900561536D99EC59" modified="2018-11-07" version="1" fragment="single">KSASPDGILVGFLKGCGLPLVSFLTLVLRSCIACGYFPARYKESNVTVLRKAGKSPEVLRTPGGYRPISLLNTHKNCPALPRLLRFSPSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L845</accession>
    <name>A0A367L845_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">TOG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_4409</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Microtubule binding protein that promotes the stabilization of dynamic microtubules. Required for mitotic spindle formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLASP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L845"/>
    <dbReference type="STRING" id="1330021.A0A367L845"/>
    <dbReference type="OrthoDB" id="46159at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060172">
        <property type="term" value="P:astral microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031110">
        <property type="term" value="P:regulation of microtubule polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902903">
        <property type="term" value="P:regulation of supramolecular fiber organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024395">
        <property type="entry name" value="CLASP_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567">
        <property type="entry name" value="CLASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567:SF9">
        <property type="entry name" value="CLIP-ASSOCIATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12348">
        <property type="entry name" value="CLASP_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TOG" evidence="13">
        <location>
            <begin position="5"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="11">
        <location>
            <begin position="180"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="13">
        <location>
            <begin position="290"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="238"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="517"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="736"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="252"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="652"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="680"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="736"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="795"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="831"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI10598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1100" mass="119406" checksum="C0A81EBC03CF9C40" modified="2018-11-07" version="1">MAETKLTDQQVTDLVALLRGDSSFDIKVQHVTAVKSGIKQHNVPEASAALLFDALRIASASQHAALVNAGFTALNHLLTRLSRQEPRLLAKEAPRTLPVIVDRLGDHKDKFRALASQALSTLSAVAPIDVERAVRNQAMVGKNSRAKEAAMQWLLQRVKETDAYVAAQMHHEQGLQFRAYVPTLMELLEDADGAVRDAAKSTVIELFKTAPNAAKSDLKRQLKNFKVRPAIEQAIVKTLGPTGRPDTPSEAAPQSRSNLGASVSSLVSERATTPMAEAQTEAIEPMYVNTHRELDDLFRGMASHFEGKETEQNWMKREQAMSTLRKLNTGNAPADFSDSFLAGLRGMLDGIIKAVNSLRTSLSKEGCSLVQDIANTLGSAIDPMVELLMQTLVKLSAGTKKISSQLANVTVDTIIARVSYSGRLMQHVWGACQDKNVQPRLYATGWLKTLLKKEAHHKSHVEHTGGVELMEKCIKKGLGDANPGVREKMRSTYWAFWAFWPARADAIMADLDPTAQKLLSKDPSNPNSPKKTAESSRPGLGFSKSTTAAGKPSVREAMMAQRKANTAAKNLPPRPGSAMAHISPVRSTSNSLAKPAAATRTRQEPTISVNAGGMSVAPMRPARRRPDMVRPATAGPYSVRDQPGPVDVASPDSANVTPKPKSSTPRRTVQRPRLGIAPSTGESSPTVRSASRIPSPRGSPPTRLARSATTVSPVSPKAYEDMTLVVPSIASALTRAREEVPEAAKDMSPPPPPPETHTPAKETTEPQMVSSAKEKPSQETVPSPPASETPSRTLKVFEDPFREDDSPQKPTLSLPVLGDKPINEDAQANGTSTESPEPSSSPEKARQKSRLLDSGINKIKAKTLEVHGFRKLQSLIRDPKTALPEDKLEPLAIGLFRYLEDPLENLPADKAQDVKAQMLATMKLLLKREREAFRPFVAQGLESLLVARGCYDGKAHVVSGLELLADDLVLLGDGPELMARLGRRLQTCDDTSTTSCRSLSMGLHVVRSLVEKSTSLKAETQEDDDEQAEGGGLEEMMITLARRTLSSPDSGVRMEAVKLCVALHRCLGDAPFWAAVEGIADDPKSLITYYIVKREREQRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8A1</accession>
    <name>A0A367L8A1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal protein L11 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_4446</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8A1"/>
    <dbReference type="STRING" id="1330021.A0A367L8A1"/>
    <dbReference type="OrthoDB" id="1091498at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00349">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.250:FF:000005">
        <property type="entry name" value="Mitochondrial 54S ribosomal protein YmL19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="entry name" value="Ribosomal protein L11/L12, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_uL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_uL11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_uL11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_uL11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_uL11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_uL11_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL11M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="Ribosomal L11/L12e N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL11 N-terminal" evidence="6">
        <location>
            <begin position="12"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL11 C-terminal" evidence="5">
        <location>
            <begin position="67"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI10646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="15759" checksum="3E70A64EF9F6679A" modified="2018-11-07" version="1">MSKAKPGALQMVKLIVGAGQASPSPPVGPALGSKGEFNARTAQYTVGTPIPCRVMVRPDRSFYFDVRTPQTSWLLLNAIESSLTNKKGVKRGARKPGHETVGTVSLKHIYEIAKIKQSELRLSGLSLEGLCRAVIYQAKSIGINVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8G2</accession>
    <name>A0A367L8G2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xaa-Pro aminopeptidase</fullName>
            <ecNumber evidence="5">3.4.11.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Aminoacylproline aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Prolidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L249_5320</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.</text>
            <dbReference type="EC" id="3.4.11.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.9" evidence="5"/>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8G2"/>
    <dbReference type="STRING" id="1330021.A0A367L8G2"/>
    <dbReference type="OrthoDB" id="10261878at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001131">
        <property type="entry name" value="Peptidase_M24B_aminopep-P_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF3">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE AN0832-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00491">
        <property type="entry name" value="PROLINE_PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="8 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="16">
        <location>
            <begin position="20"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="369"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="369"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCI10701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="513" mass="55934" checksum="4C6AF741C99335B2" modified="2018-11-07" version="1">MRIRVPVREASACSKPVVKYPGKLHARRVVEQLGSKCGLIYLAGQSERNLENSDQPVPFRQRRYFFYLAGANFPGCHVTYDIAVEELVLWVPYVAPKDVLWYGSTPSPEECMDRFDVDHVRFVDGLESYVDEYRASQPSAPIYLLDAKQRPGWMNRDGFRLQDTALKDAMDRARVVKTEYEISMIRKANDISSAAHRAVASSLSKLTSERDVEAVFQACCTSNGARTQAYPIIAGAGSNASTLHYDANDEPLAGRELLLLDAGCEWNCYASDVTRTMPISGRFSPCAAAVYAVVCEMQRVCIRAVRPGACFRCLHLLAAGVALDGLLKLGVLRGERREIYEAGTVAAFFPHGLGHYVGLEVHDVDGGEPLLSSSSSSSSSSSSLSSSSSSSSSSSSSPPSPAMIGGKRVSITPSSLQAMTKDDEATTNNKTTRRGKQGLRPNMVVTVEPGIYFCRPYLEASFVHHPIHGRFIDGHVLERFYPVGGVRIEDDVLVTETGGENLTAAPKAEVPFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8X4</accession>
    <name>A0A367L8X4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5449</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8X4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI10875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="101" mass="11655" checksum="FE79582A4B58E50B" modified="2018-11-07" version="1" fragment="single">SSRPKRKPLLPRLLFDRDKILFLAKIAFFFKQGEKYAYNIGHFLDYFNSFLATSLREILLALYITLSLKAPPIPSLLTKVSNFTNLFSKEKASALLLYYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L986</accession>
    <name>A0A367L986_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_5439</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the importin beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L986"/>
    <dbReference type="STRING" id="1330021.A0A367L986"/>
    <dbReference type="OrthoDB" id="2016913at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051345">
        <property type="entry name" value="Importin_beta-like_NTR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057942">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363:SF33">
        <property type="entry name" value="IMPORTIN-13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12363">
        <property type="entry name" value="TRANSPORTIN 3 AND IMPORTIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24140">
        <property type="entry name" value="TPR_TNPO3_IPO13_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI10987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1008" mass="111595" checksum="ADC9BCB7E9EDF6F0" modified="2018-11-07" version="1">MEDPRLHLSLDQVEHLILSLYQPNPPQIIADAQASLSRFQCSPRAWAMIQDLLERPDENVKFFGALTLIIKLNKESATLSNDDATELLIRLIGWYIRSLMQADSLLVLKKLSSAIATYFIQFHYLWPCYLRHLVICLASSRSLSTKATLDTGDTTAALNSLCAKRLQAVIWVLTSVMEDVSRIDLTAGNKSVPLCLYNAVMRNVPDAMALMTRCLSSGRSASNIFIDSIKCIQSWVSFTQKTSPALTHDTLFLRPLVGAVVLSLPDRDMFEASAELLVDILCNCPSLLTDEQYDSLAKVLGASWAQDRYHRLLKGDFEFESLQFGQLLLAFGEARTEALMQSNDSSCSQLLSALCDLLNADGYPVAEDKIFVSAVEFWSTYTEEMADVVHFGPNVSSNSWVPNAAVYVSQAVSNAWRKILYPPLDVFQQWDSTDRVGFNDARKDVLDLLQSAYTVLGSGLVANFKDLILSTLQSSSWLPLEAAAFCLGGLADCGKGDGRFDEALTSVFSSPLFSTILSMNQDIDLRTRQTCFYLIEQYSEYFERHITLLGPTLRLLFAALSEQSTAASASRSILLLCSSCRHHLYPLIDEFLHEYSTRIMETRLDCVSNEKVLGAIASIAQAIPDPDRRHGVCTRILEFVQNDVTVAQEIGEASDPGPLHHCQSVRCSRIIADEHPATHTGLRALKCLVSVGKGYQSPSDTTVDVDHGCNQQDESSGALTGVHDKILRIVVQLQHTFPKSSEVTELICSVFRCGFSEVDPGPFAFRPSMVAQFLMSNSGEPRSKGLFVSSACSLVSSVRCNGSSDRTAIFSSLLLWVVGLLRQLPDPDCDPELTQNGIEFASRILARAPLVVLGLQPKEAAEFFLMFTINTLDGREPLPKGAAADFWTAFVSLKNDDHDVEPAMRRAMQTLGPHLAQSLARNFGGHALRSELDKLSEPLKKLVVRHPMAKEWLQSGLDHCSFPSNQITAEQKDIFIKKIISLRGSRATNQIIREFWLTSRGSNFAYAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9A5</accession>
    <name>A0A367L9A5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Gelsolin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_5250</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI11010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367L9A5"/>
    <dbReference type="OrthoDB" id="5385013at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005619">
        <property type="term" value="C:ascospore wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005628">
        <property type="term" value="C:prospore membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11290">
        <property type="entry name" value="gelsolin_S1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055795">
        <property type="entry name" value="DUF7371"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052786">
        <property type="entry name" value="Spore_wall_assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007122">
        <property type="entry name" value="Villin/Gelsolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN LDS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34292:SF1">
        <property type="entry name" value="OUTER SPORE WALL PROTEIN RRT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24086">
        <property type="entry name" value="DUF7371"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00262">
        <property type="entry name" value="GEL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="485"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="564"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="625"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="3">
        <location>
            <begin position="64"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="3">
        <location>
            <begin position="188"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7371" evidence="4">
        <location>
            <begin position="1835"/>
            <end position="2026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="726"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="776"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="844"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="776"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="844"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="916"/>
            <end position="926"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI11010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2068" mass="213315" checksum="70CD0BFDDC3799AF" modified="2018-11-07" version="1">MAPHDGLVHPKEYDILDSNVEFVGSEMDHRVKYNSAATEPAWNDGAVGSEPGLRVWRMEQFQVVPWPKQRYGDFYDGDSYLVLHSQRLADTQKLRHDIFFWLGSHTTQDEAGTAAYKTVELDEFLHGAATQHREVQCAPSDDFLTLFPRISILSGGVRSGFRHVEDKDKQPTRTLLRVFQAGTGGANVVVYEVQPTWRRLDDGDVFVLDEGYKIWVWQGRRCSPMEKAKAAQVVHDMTQAKHVDVEVVSQEEARSRRIIELLGGDDSTPRDGFTQPRPLNVPSAAAAAAAAAPRRLFRLSDASGRLELSLVREGGQISAADLDGNDVFLLDDAGRGLWVWEGRGASRAEKARWLGAARAYVQRRQADCAEALAMPVAKVVEGFVTAHFSSHLTCFALETVMDGTIPVSIDSHACLSRPASYLRRAAIAASYPLRGIWYCARDRDFWPLFAGRLLPLSIISLVVYLVLFTFAFLPQYAFIAIIHGWGAWLNAVVLTLGEGLVITQALFEGFFVDECRVDVFDAVLIKRGLADLVAPNRLLHDDAPSAVKMLGKPTSPAAYQPWSVIQIIELIVFLPLNLVPVVGTPAFIIITGTRLGKLSQYRWFQLRGLSRRERKREIRTLTWDYMWFGTVAMVLELVPLLSFFFLLTTSAGSAAWAAAMEHHRRRAARAVVESRAAARGDEPLYPIASPVSLPQSSSSRSIGSAMWPVARRAFLTVMLRSPDGGSGAEIYGEPSRDAQGEGPSTTLESLPDSPKCTAQADTTTVFVTVYPTSPASADDSLSAAGAPDETARHTARVHSGGHSSLHSVSIWTTVTWDLSGISAGVSGGSGSPLSGLGATASSLVNGASPTTQGSPDGDYGDATGSAAPVGWPRPTVTSDAISPGESGSSGGDAESPFGTGLTAASDGFPSAYGSANEAQATPSDHGSSLGAGGSPTWQTVVTDTEVHWITGSSGPTPVTVLSEHTIFGVGPAQASAAGEAVTCLTTTGPDGRPTVFQWPGGSPQANGSPVVSTAGASDDNGDAGVQAFSTLNAPASAGAASTTCTKYTVLGTDGVPTVVHSSWLVPEVAPVTAAPGSLPSGVSGPVSAQNAPNGAGVTTCTSYTILGPDGRLTVVESTVILPGTAGVQGGDVPGGFPAQVTSLTGGPGSVQPGDHQLPGGGHVTCTTFTVLGADGRPTVVDTSFVAPGPAATPVTTVTAGGVFTGVPSQITNSAVLPQPAGGAGTQGVTTCIIFTTLGPDGKPTAVESTVVVPATIVPEGAFTGAPAQITGSAVLPQPAGGARGVGAQGVTTCITFTTLGPDGAFTGAPAQITGSAVLPQPAGGARGVGAQGVTTCITFTTLGPDGAFTGAPAQITGSAVLPQPAAGGAGSQVVTTCITFTTLGPDGKPTAVESTVVVPATLVPGGAFTGSPAQITESAVLPQPAAGGAGAQGVTTCITFTTLGPDGKPTAVESTMVVPASNALPPVTVLGLPSFASAQPSNLPQGAPVFTSLGSPITTCLTFDVLGPNGVATPVVRTVVLTPAAAPSVTTLGYPSITAQQQATDLPQGVPPYASSNGAITTFVTMYSVGPNGVATPVVQTVVLTPSAAALGLPTAPQTPNAAGLTLQPPGPVVTAGSPPTLAPGAPNLNAYGPDASDVQTAVPPPGVVSGLNVGTLTGPLTTVLTLVAGQPGASGAAGLPFPYGDGSDGTGVSAAGVGAQPGDANNNGYGWSPTANAGPYGPMSSPVVPQPLLTVTTLQTVTWTNFIPEPTTTYTMNFPLTTLETVTISAPLGKRLLRRQQSSLLLDPSWSNATAIVPPVAPVPTPVPDVPVSAVSLVPTVPSSAPVCAFGGKIGNTTVNFDDIKPGPLFNPSGDVWFSEGFLVAPPAAQVAQSFVPSSGGQLVEFVPPSLASLPIGHLGSGDRAEVGVGPNAPKPCFRFDFFSAELGCAATAAEGWCEFEVAAYRYDPAVTFEQSIAWSETKRVPACPSFPSGSCALTPVDFEGYTNISSVLIYVRVGLEMRAWWGDDFKFGWTDNSCEAASCRSLAAPQHVKRETVELALRRGIWHWTPAGLQRLDDDYILESAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9K1</accession>
    <name>A0A367L9K1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9K1"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="144" mass="14833" checksum="5992608C09BD6AA4" modified="2018-11-07" version="1" fragment="single">MLDITSAFDYVLYNKLSELLYFIRAYTADISSLTLNGSVVVPTQEARMLSAGLPDPSPRLGVPVTTRVAAGSPPPGLSSPPPPAATTPSSTNTLFSSTATSSLYLLAGTSITLLSPSLLQSRGAAPVPPSTFSSVRAASGIYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9M3</accession>
    <name>A0A367L9M3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9M3"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="76" mass="8025" checksum="2400F2105FF08EF0" modified="2018-11-07" version="1" fragment="single">RERQTLLHTQGTRPEGLGGSRDVGPAVAGPRPPYVTESEAATATARLRRTAATAVRAVRANKTRKALGTGTYGYGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAD9</accession>
    <name>A0A367LAD9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">carboxypeptidase C</fullName>
            <ecNumber evidence="2">3.4.16.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_7143</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.5" evidence="2"/>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAD9"/>
    <dbReference type="STRING" id="1330021.A0A367LAD9"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF113">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CTSA-4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI11397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="298" mass="33091" checksum="524675487B03C3FB" modified="2018-11-07" version="1" fragment="single">MRFSVYAIVLGIAAQPIYPHHHQSTTHSDSHQVRGPATSGSRQKSLDMRLVSKATLDNLGLENGTQYAGYLDDNENDKHLFFWFFESRNDPQNDPVILWLNGGPGAASIPAIINELGPALLGEEKGSRIRRNPWSANNNASLLFIDQPVNSGFSYGGQAVNTTEAASKDFYPLLTLFFDRFPQYQKQDFHMAGHSYAGRFIPIFALDILSHPDRNINLRSIMLGNPHTDPLSLFKSAEPMACGQGGRPAVLNGSQCAALKTDMDLCLDRVKTCYRTKQCEDRTEACGKALHANYDRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAH5</accession>
    <name>A0A367LAH5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7542</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAH5"/>
    <dbReference type="STRING" id="1330021.A0A367LAH5"/>
    <dbReference type="OrthoDB" id="366390at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI11416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="90" mass="9842" checksum="B57C520914BCDAC8" modified="2018-11-07" version="1">MDATSSSSSSPPPEVVALASRMYDAARRGDLAVFQQALPAGLPANLTNEKGETLCVQMFQQGQRWAGEMEMAKKALEEKKNKNKNEKLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAM3</accession>
    <name>A0A367LAM3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="13">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">L249_7191</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RAD25/XPB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="13"/>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAM3"/>
    <dbReference type="STRING" id="1330021.A0A367LAM3"/>
    <dbReference type="OrthoDB" id="10262986at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18029">
        <property type="entry name" value="DEXHc_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18789">
        <property type="entry name" value="SF2_C_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000077">
        <property type="entry name" value="Probable DNA repair helicase RAD25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000117">
        <property type="entry name" value="Putative DNA repair helicase rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050615">
        <property type="entry name" value="ATP-dep_DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032438">
        <property type="entry name" value="ERCC3_RAD25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001161">
        <property type="entry name" value="XPB/Ssl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00603">
        <property type="entry name" value="rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274">
        <property type="entry name" value="RAD25/XP-B DNA REPAIR HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16203">
        <property type="entry name" value="ERCC3_RAD25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00851">
        <property type="entry name" value="XRODRMPGMNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="352"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="569"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="766"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="819"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RCI11465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="829" mass="92997" checksum="B76208388A5978E1" modified="2018-11-07" version="1">MPPKRKAGAIPPGGSKAGRSSRLSTPGAATPRNLESNDEPEEDEAPVDEVLERDIDKNIDRFSLDKYQKKHTVREPLPHIFGDRDFSYLELKKDHRNRPLWIDPQKGRIILESFSPLAEQAQDFLITIAEPLSRPTFMHEYALTTHSLYAAVSVGLSPHDIINTLDRFLKTPLPVEIRDFITSCTQSYGKVKLVLKNTKYYVESPDPNMLQTLLKNPKIGPLRVQGTEEITTSAAPKIGGLVIPGTKNAAGVKQASGLQPLNADQDKDGQQVQEGDAITTLNEEDDEDQEVTHSFEIADKDVETVQKECLNLGYPVLEEYDFRRDEVNPSLEIDLKPGTQIRPYQEKSLSKMFGNGRAKSGLIVLPCGAGKTLVGITAACTIKRGVIVLCTSSMSVVQWRQEFLKWSNINPDDIVAFTSDSKGSVFTGSTGIIVTTYSMVTQSRARSYDADKMMKFLTGREWGLMLLDEVHVVPANIFRKVTSSIKTHSKLGLTATLLREDDKISDLNFLIGPKLFEANWMELSKQGHIARVQCAEVWCSMPTEFYDEYLRAPSRKKNLLYIMNPRKFQACQYLINYHESRGDKIIVFSDNVYALKAYALKLGKAYIYGGTGQAERLQVLENFQHNPQVNTLFLSKIGDTSLDLPEATCLIQISSHYGSRRQEAQRLGRILRAKRRNDEGFNAFFYSLVSKDTQEMHFSSKRQAFLVDQGYAFKVITQLANIEKTPGLAFATASERRELLQKVLVENDTMDEDEIIDDLFHSGTMGRKKKRGGARRTAGTLGELSGGQDMAYMEQNKRMNQSLKKGKGKKDSSAFFKKIGRENARRAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LB08</accession>
    <name>A0A367LB08_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_7755</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LB08"/>
    <dbReference type="STRING" id="1330021.A0A367LB08"/>
    <dbReference type="OrthoDB" id="5365785at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04479">
        <property type="entry name" value="RPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013970">
        <property type="entry name" value="Rfa2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051439">
        <property type="entry name" value="XlnR/Xlr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47663">
        <property type="entry name" value="XYLANOLYTIC TRANSCRIPTIONAL ACTIVATOR XLNR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47663:SF1">
        <property type="entry name" value="XYLANOLYTIC TRANSCRIPTIONAL ACTIVATOR XLNR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08661">
        <property type="entry name" value="Rep_fac-A_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="702"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="10">
        <location>
            <begin position="427"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="79"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="218"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI11610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="907" mass="99162" checksum="F33ECBAE5B1175BF" modified="2018-11-07" version="1">MPPAETGTQEGAGEAGLSPALAPVSVQAQTLEHARPRRRTRRACDKCSASRTRCDGEWFVLFEYGYTCRYNREVKKRGRLPAPTGRNIHHASPPATPPASKTISTVGSIGPKHTTPGDDLQGPREGADAPQQMMTGRSAHAAMSIPSLTQAALHPSPRPLVSADGPPIRSRAASSVPDGPLAESDMLISDDSASYASPATGGLSIELGRGSFGRRRTSFRSAASNDPPRTSVSTATSAPDSILPDVLHQTPSDECCYRFLDPVLPFIRRIIPASVACELLDIFLTDPGSSLFRGASPYILTRVFRKKSITHPTSPRHTTPALLATILWCVAQTADVMLLHVPGTRARVVNDLYDLATSLVSERDPDRWRRIHGGLRAESEVPHPSLPNPTSVPLTTAANEPAGVVDDVLTFILLSIAVSGSDFKSDCYKWWSKALRLALSLRLNREDERCTAPVSPCANPLCSCHRDATGDASLADLERREERRRVFWLLYSLDRHLSLSFNTALSMPDSYCEVFAPLPETMWEKLEDLTPAEMPLRVLGPPTLASGTGFFEYFLPIMAILGDIIEVHHRRRHPRLGDQEDSHAVAVIQDLLASYELSLSSLTVPSRDLVTGLSTPALHQDGIRLAAYDAADHTKVRLVRAYSTHMLHVLHVLLHGKWDAISMLDDGEDWITSKRFTECATHAISASQSVSTILAMDPELTFMSYLFGIYLLQGSFVLLLFADRMPQLGPNESVEQACENIIRAHEVCVVTLSTEFQKNFRKVVRSTLYSVRGSGTTNWEEHRARRRALLELSIRIPAMSEQMCAPRVTAVYLNSSFAGRLVTVVGKVSQLHGDQANIAAEGVIKVTLNRDARLTVGNAAQIIGKVNPDMSVKALSSRDLGAGVDFDLCNAVVEATHRHQDIFITSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LB16</accession>
    <name>A0A367LB16_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Branchpoint-bridging protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_7752</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BBP/SF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LB16"/>
    <dbReference type="STRING" id="1330021.A0A367LB16"/>
    <dbReference type="OrthoDB" id="6777263at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045131">
        <property type="term" value="F:pre-mRNA branch point binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045071">
        <property type="entry name" value="BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032570">
        <property type="entry name" value="SF1-HH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047086">
        <property type="entry name" value="SF1-HH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208">
        <property type="entry name" value="RNA-BINDING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208:SF45">
        <property type="entry name" value="SPLICING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16275">
        <property type="entry name" value="SF1-HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="K Homology" evidence="7">
        <location>
            <begin position="89"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI11611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="261" mass="29035" checksum="984A35AC618EE309" modified="2018-11-07" version="1">MTAEQLDAYLMHFRIQEITLKLQTQDYKIPASQSRCPSPEPEYDSSGRRTNTREQRYRKALEDERHALVEAAFKTIPNFRPPRDYHKPTSFTAKVFIPVAEFPSVNFIGQILSPRGNSLKALNKKAEASIVLRGKGSIKEGRGYGQGSRSTTSQHLGEPLHCLILATSPNRLQKAKQLVQDVIDAATTSDNQNKRKRQQLRELAIINGTFRDDENKGLQIALPLQSSSNSQLGAVTCQLDSDLGKEDTIDTEGRPASSSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBW9</accession>
    <name>A0A367LBW9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_4209</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000009">
        <property type="protein sequence ID" value="RCI11901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBW9"/>
    <dbReference type="STRING" id="1330021.A0A367LBW9"/>
    <dbReference type="OrthoDB" id="4356615at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056030">
        <property type="entry name" value="DUF7611"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056031">
        <property type="entry name" value="DUF7612"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056032">
        <property type="entry name" value="DUF7613"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056033">
        <property type="entry name" value="DUF7614"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24586">
        <property type="entry name" value="DUF7611"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24587">
        <property type="entry name" value="DUF7612"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24588">
        <property type="entry name" value="DUF7613"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24589">
        <property type="entry name" value="DUF7614"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7611" evidence="2">
        <location>
            <begin position="498"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7612" evidence="3">
        <location>
            <begin position="656"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7613" evidence="4">
        <location>
            <begin position="789"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7614" evidence="5">
        <location>
            <begin position="948"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI11901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1095" mass="121275" checksum="C9450EA52A349672" modified="2018-11-07" version="1">MENEPPTTADEGRSSRRGRFIDKLFGGGRERKASEATPESQAALDAFLHSTTDRLDVTNALPVPPPPPKLAQIDTSISRYPQALAVNQQAQSNRPLAPGKHESGLPPRKSPRPNKKGLTVRFTDSYPEVIGEGGDECELPVSDLRRNKVKRRPLPASSIRATTDAGSKTPPTDADADADFQPKPLARTQTGYSSIYEPEDDSASHDQNTSSSREAAYLNTTARRDENRKSFIEAQQAQMREAEGAAFAQAARTAQSTSGHGRRPDEDASDGPPLRISTSSDTVTRRGPIEYSPAASINSNASSAYHQSNPSQGSLAAPPLSSSSHNGISPFNNPLAARMASVKLRDGAQGDESLSKFATRTKHLFELFRLHAETVGPLRSRTFRECGRAGLWWFLKGRMGLELAIRGRPTSPEAQMHNEIDRQQAYSNLAKTYWLCEEVIPEIADSQRQQPDAETTTVVSSLNSALRKLSQSMQRNGLLPPEEPFLPQTIDKSIWLNYPALSQDMVALLSGNWSSGLTPMQRPVSSTQLLDALPLGDTSENFNYGRFMADAFLMEQGREAQKLCLPCILSVVRPQKQRGLIFLLASQNGSVQLAVQDDGAGPTWEHVRWRNDACALDVRLPRGFLLSVQFGQSDFVTVRNMYDFGAKVQAMLHPLSDEKAVFRNTLRSFQYLESEPPSRAFPKEPIGRCEVALMEKTYKENGPAGRRCWHCGFRIAVNTGPSTRSVNGVQHSFPPALPVQFGFFRAEGNAPALSVKYESGRYSGRMVLVFNDEKERVAFHSLLAGTALNHDEKVTADVALKTFMVSESVREPLGVAPFSRLAWRAARVINAELGGGGVEQPATVLSDKLKVVLEYQDGMVTDRINVAPGELRMRLEVSNAKVLRVMRQQQRDMTVSVSETQASKELPRSLTEAQQLLMSKPTIRSYEFNQIKDLHEFQAAVTGFEVLFDGLAATFAISRRRMVVPIHKKWEAGFTRIQVVRLEDRQVQLVAFFEDFHHGHCINFVLKGTDVYESFHRSGRSGIKFVDAKFPLPRVPADKDGDLDDVSFVCLDLPDLPGEHDDITIMFERETDRDRLCECLPAPVKGSSRISSRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBX3</accession>
    <name>A0A367LBX3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Autophagy-related protein 18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_4199</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat PROPPIN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000009">
        <property type="protein sequence ID" value="RCI11916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBX3"/>
    <dbReference type="STRING" id="1330021.A0A367LBX3"/>
    <dbReference type="OrthoDB" id="1667587at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048720">
        <property type="entry name" value="PROPPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11227">
        <property type="entry name" value="WD-REPEAT PROTEIN INTERACTING WITH PHOSPHOINOSIDES WIPI -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21032">
        <property type="entry name" value="PROPPIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="293"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI11916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="51434" checksum="6585D553323051A6" modified="2018-11-07" version="1">MASLSLNFITFNQDHSCLAVATSKGFRIYHTEPFSRIFSSDDGNIALIEMLFSTSLVALILSPRHLIIQNTKVCCTPPTPPRVLPFVADYRGESQRSSVICELTFPSAVLAVRLNRKRLAVVLEEEIYVYDISNMSLLYTIPTSPNPTAICALSPSSDNCFIAYPLPKPRENSDSKRPSHAPPLSTYVAPTSGEVLVFDTLSLKAVNVIEAHRSPLSCMCLNNDGTMLATASETGTIIRVFSVPRGQKLYQFRRGTYPSTISSMSFNLSSTLLCVSSASDTVHIFRLGIPPGNTTPAGAPIEPPCSPGQERWPGARGHDDGESPANSQAESPRSDAVDSNVIPAGANQQGHRRQSGSFGTILRRSSQFMGRGVAGVVGSYLPQSVTEMWEPMRDFAYIKIPKSASSGGTARSAGGNATSPLRSVVAMSSSSPQVMVVTSDGGFYVYNIDMENGGEGYLVKQYTVLEGDDRNEASTYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBX4</accession>
    <name>A0A367LBX4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SPT23/MGA2-like DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_4215</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000009">
        <property type="protein sequence ID" value="RCI11929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBX4"/>
    <dbReference type="STRING" id="1330021.A0A367LBX4"/>
    <dbReference type="OrthoDB" id="71307at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057962">
        <property type="entry name" value="SPT23_MGA2_DBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25603">
        <property type="entry name" value="SPT23_MGA2_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="SPT23/MGA2-like DNA-binding" evidence="3">
        <location>
            <begin position="225"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI11929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="439" mass="50590" checksum="F187D7FFBDD6424C" modified="2018-11-07" version="1">MEQPYKWYVSPAASYAMVSGHPSPFPDAFISSPFIGSEDGDNYPLVNQDLELSVRPRSLEQPQQQQQNEQQQHQQHHHHHHQQHHQQQHHHHHQHQKSRRPSLDLASLEQQQQQQFIVDQSNEPDQQPPMTYSSPLYTVPAFYTGGLPRPILPRPISAADAIVVLISIVPVLLVLVLVPLFLLVFLLVFLVLVLVLVLVPLFLLVLVSLFLLLQTPAFFIQHPNRRTRVETQINIRMMLSALPPAVTKLCFPDHTILRTKQLANPPATKSPDTLELYVQLVRSADVSSPELERSAFERAATTAHRTHGDLRICLGCMSRERTRAWRKKGHKEDEIQRWLRDQEHRIIVFNTPQLVHWSPDINDAAFQVETPMRITCYCRHHKETTGFNVIFTLKDWQDRVVAQARSDSIMITDDHKSKDQYLGPPKAGRRRTRASPTPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBY3</accession>
    <name>A0A367LBY3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DDB1- and CUL4-associated factor 13</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">WD repeat and SOF domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_4220</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat DCAF13/WDSOF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000009">
        <property type="protein sequence ID" value="RCI11926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBY3"/>
    <dbReference type="STRING" id="1330021.A0A367LBY3"/>
    <dbReference type="OrthoDB" id="10249065at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007287">
        <property type="entry name" value="Sof1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051733">
        <property type="entry name" value="WD_repeat_DCAF13/WDSOF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851:SF0">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA U3 SNORNA ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04158">
        <property type="entry name" value="Sof1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="62"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="106"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="281"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="324"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="Sof1-like protein" evidence="11">
        <location>
            <begin position="357"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="409"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI11926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="448" mass="50368" checksum="26C7A2826CAC453B" modified="2018-11-07" version="1">MKIKAISRPISSHQAAGSDAVRLPRNLDSALHPFERAREYQRALNAVKLERMHAAPLIGQLGRGHVDGVYALAKDPSATDRLATASGDGVVKVWDLTDRDTSVWHASAHANVVKGLAWTRDAKVLTCAATDRSVKLFDPYGTAADSQPLSSWLGEGPFSSLSHHRSRDAFAAAQSASISVYDLGRHSAAPETLRWPTAVDSITDVSFSPVETSVLASCGADRSVVIYDLRTSTPVFKTVLNFASNRVAWSPMEAFNLATASEDHNIYLFDMRRFDRALNVLKDHVAAVMDVEFSPTGQELVSASWDRTVRLWSRDRGHSRDVYHTKRMQRVMAACWSPDAHYVFSASDDGNVRLWRANASQRSAIKSARHRQALEYNEALIARYAHLPEIRRISRHRHVPKVVKKAAEIKSQELQSIKRREENERRHTKKQFDKRRSEREKMVLTREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LC47</accession>
    <name>A0A367LC47_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_1076</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LC47"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF177">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="445"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="496"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="606"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="144"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI12003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="641" mass="67885" checksum="C41B3DC24AF82717" modified="2018-11-07" version="1">MPRPARDPPREGQPTSRPISAISPSWRLSTIGYDELSVFRPLEVTHVTALDFIFPQRPASWRQSVVSNTEHSTRFPLRASIVPPAKVQEPGSRTTSSFVESPSALSIASALEVIPPYAQSTSSGHVDYGAQQSEYPSGFKLWIMIAALVSSIFLIALDMASRGAIADLPQTIVATAVPAITDEFHGLQDVAWYGAIFFMTAGGFQSTWGKTYKSFPLKMGFLTAIFIFEVGSLICGVAPSSSVFIVGRAIAGVGAAGVGSGSYTLVAFIAEPKKRAAYTGLLGAIFGIGSVLGPLLGGVFSSRSTWRWCFYINLPIGVLPVLTIVPLKEKLLQMDPLGTCLLMGAIITYLMAVHYGGQIYPWSSSLVVGLLVGSCLLSIAFCVCEYWQGDRAIVIPRLFKQRRIGLSAIYSILQSGAFFSMIYYLPLYFQAIRGSDAVVSGVQNLPFILAAMLGALGAGIFISSTGMATLVMVGGAAIGTLGCGLCYLFDMNTSTGTWIGFQIIAGVSLGGALQIPVIVGQVSVEPEDLSSATSMMLCFQTLGGAIWTSAAQSAFVNRMIIAVPTLAPGVDPMRVVATGAGQLRTVFRAHQLVGVIAAYLDGIRTAFILSCTAVGAACVLGLFLPWKRLDVVAVRENSGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCC8</accession>
    <name>A0A367LCC8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">L249_0081</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxiredoxin family. Prx5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCC8"/>
    <dbReference type="STRING" id="1330021.A0A367LCC8"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03013">
        <property type="entry name" value="PRX5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20356">
        <property type="entry name" value="Rcat_RBR_HHARI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16625">
        <property type="entry name" value="RING-HC_RBR_HEL2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1750:FF:000007">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000019">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045840">
        <property type="entry name" value="Ariadne"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048962">
        <property type="entry name" value="ARIH1-like_UBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037944">
        <property type="entry name" value="PRX5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19422">
        <property type="entry name" value="Ariadne"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21235">
        <property type="entry name" value="UBA_ARI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="13" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="431"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="435"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="212"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="259"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="14">
        <location>
            <position position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR637944-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RCI12088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="823" mass="92360" checksum="1CAE3761595414C3" modified="2018-11-07" version="1">MAFRSALGRAALIRPIARSFHSTPRASVSVGDQVPVSGGLYEDSPDNKVNLADEFKKADGYIVGVPGAFTGTCSSLHIPSFINHPKLKEAGHVFVVSVNDPFVMKAWREQLDPKGTSRIRFLADPTAGFTEALDLSWDGSAVFGGPRSKRYALKIKGGKVAKVHIEDNLAVAQDTLAENVLLTAYPVKPSFLASLCRRALLVIPSSPSSPVSGPLSWPQSLSPPHHSHSRVSSSTPKPPPTSQVWVVTIPPLLRKRKAAEATISPDQGDDSQAKRLVTSAAASAAPPTPVTTGMDSEEEYMSNMSSDDEIMQEYSGDEMSAAEEFEEYDFAEADPNFGLTPKDIGKAKRPSHAVAFKVYQPDDIQRQQLEMISEVNMILDMHKEDAAILLRHFRWNKERLLEDYMDQPEQVLEAAGLRNNARALPKLEVIPSFVCEICCEDDDELQSFALKCGHRYCVDCYRNYLTQKIRSEGEAARIQCPADGCGRVLDSRSLDLLVTAELTDRYHELLNRTYVEDKDIFKWCPAPDCPNVIECGVKKKELDKLVPTVECRCGHRFCFGCPNPDHQPAPCGLVKRWLKKCADDSETANWISANTKECPKCSSTIEKNGGCNHMTCRKCKYEFCWMCMGLWSEHGTSWYNCNRYEEKSGAEARDAQARSRTSLERYLHYYNRYANHEQSAKLDKDIAQKTEKKMIQLQTTSGMSWIEVQYLNAASQVLQTCRQTLKWTYAFAFYLARNNLTEIFEDNQKDLEMAVENLSEMFEKSIQELADPKLKVDIMDKTSYCKKRRLILLEDTAENLANVKWTFNSDLTSPCSSTANARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCH0</accession>
    <name>A0A367LCH0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_0754</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCH0"/>
    <dbReference type="STRING" id="1330021.A0A367LCH0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="806"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="937"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="673"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="808"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="945"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="977"/>
            <end position="986"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI12116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1162" mass="131988" checksum="CA580E2BDC2EDAF1" modified="2018-11-07" version="1">MAPSDYRIDETISKYMPDGIKANQMMLFPDRSTGQKTLPMVYGRYAGGEDDETGPTFEETLEEGLKFKQPPWYVARTDWPEEDTRFEDVQAWNPHCTDLGKFIIKANKLQWLSSFEAGAVLRIIARGMAPLFHIYEWPLTIHATNDNKDSTNTAFRKDVRYERPSFDFYVETGGSRFAGGLANFVSTDAPGGFHWGAYIWDWKSRIIYIFDSGRSGRVQRAKRLVKSWFLLLSEHWLLDHMDYILVGSSEQEYGWECGYLALTALQHWVRGHVGLPPSEVVKLGKVPKDTWIEAYHPINLCNFTMNQEMVGVSRFEDVQAWNPHCTDLGKFIIKANKLQWLSSFEAGAVLRIIARGMAPLFHIYEWPLTIHATNDNKDSTNTAFRKDVRGFHWGAYIWDWKSRIIYIFDSGRSGRVQRAKRLVKSWFLLLSEHWLLDHMDYILVGSSEQEYGWECGYLALTALQHWVRGHVGLPPSEVVRLGKVPKVAAKWFGPPMAAPPEGELLLRDWPIRRLDDEVVDYDELLQTTVASLCEMAANELGMEGDHLIKGMAIRFPFRQWKWTKHKEIAPSETLTTLGGPSPSRFTWNYRTARWCRVITEASFLRGNITRITLPEEDFFATVEMSDAESQNESDLFSVNEEDEEYMDIAWRVDQLQAIADAALAIGEDPPAEYIEASNALAQLEARMDEDERAAEMAYRARRRIQPTCLWRPPAFGCHEVRLRGWSPVRGEFTHVTAVTNRPTKGHVGWPQRAQVDYDPEEGLIISRREDWSRVTTRRDEWLRTSPPAALDDTDNPLGHEDAERIEAGDDEAFDQDSNEGQEPLGMDYSRSTRDSASPLPSSNRDEDPILNPRESSSELSDPFVGSPTDPFAEVPSPTLRALQLSSELSDFSIDTPSDLLFDNSEGDEAAKKIAAEERKTTTKKIVVARKHTKPVKKITGEVDLNTPTKSGAQSQPQLYTPVPPQPVLQEPDSILRRGTRERRPTKRAFDQPETPRQTPSKKAKTPVVTPKAIAPQRTPMMNLVDYSDFEGTTVEQLGREEVVLDPFDQAVRGIEPHTNHTVWTKDCQPSEKGAGDKLGVAGAIMAYTGRALARLELRQSRQIPHSLRSDSFVSLQPPGLMSREVWPEIHSAVREHLIAYHGSQGTRLSRAERAAKRDSNRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCH7</accession>
    <name>A0A367LCH7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_0711</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCH7"/>
    <dbReference type="STRING" id="1330021.A0A367LCH7"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF40">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="317"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="342"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="25"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI12124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="434" mass="47481" checksum="ADA28C9DC41085B5" modified="2018-11-07" version="1" fragment="single">MMDHAMAGWHKPDHVAGSSAPAVMVGLFVASGGLLFGYDTGAINGILAMPAFKRRFATSCEPELCTREISIIVSILSAGTVVGALLSAPAGDSLGRRITLLVAVAVFCLGSVCQVCADAIPLLLVGRALAGVGVGAISVLVPLYQSEMAPKWVRGTLVCAYQLSITIGLLTASVINILTSPLGDSSAYRIPLGLQIVPALVLTAGLLLLPETPRFLVKKGRDEAAGLSLSRLRRLDMTHPALIEELREMMANHQYELTLGPDTYRDVFVGTPHLGRRTFTGCGLQMLQQLTGINFIMYFSTIFFSRVGVASPHAKSTIINVINVVSTIPGLLVIESWGRRRLLMVGALGMAVCQLLMASFSTAAAGRVDLAHVSQTMVVVFCSFNIFFFFFFFFFFFFFFFFFFFFFFFFFFFCFFFSSFSSFWTLAMEFSFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCK0</accession>
    <name>A0A367LCK0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">serine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Seryl-tRNA synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA(Ser) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_0382</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="1"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCK0"/>
    <dbReference type="STRING" id="1330021.A0A367LCK0"/>
    <dbReference type="OrthoDB" id="337660at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="10">
        <location>
            <begin position="696"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="17"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="282"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="405"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="509"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="657"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="418"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="433"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="448"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="534"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="667"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI12146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1019" mass="111232" checksum="D13ABB09FE5897ED" modified="2018-11-07" version="1">MASANAPAHRSLYGIRSTAPNQSQPHTPPRSPHVLSGSYGSPSAVRAEDDLVLIEIGSRFIRAGFAGDSSPKAVESWGPEKRRRVGDFGAWQQQQQQQQQQTATGVWAADYEIWRFDLRDFDLDLFQHRLDRLLRDAFTRCLLIDSRPRRMGLVLDPAVPIPLLSAVLDTLFNNFQTPIVSLLSCPTMSAVAAGVRSALVIDMGWRETVVTSVYEYREVKTTRSIRGGSLLLNGLYDLLRSILPAGEAKGKKKRVVSFDECEDIMCRVMRCRTCVTKSPRRQPAQLDTVEEQDESGTEAKQTDGQLEIPLRSTDPPTTLSLPLGKVADLCDDTFFNGSPLPDDDEFPIHLLVYNHLLQLPMDVRAVCMSRLMFTGGCSDILGIKGRTVDEVMSMVEAKGWTPVKGKGFEQARKKRSSQNRSDPTSQMTVDKSSGGGGGGGGGGGEREREEEEEEEDPVEAKIWRNRPVTRPLQGQLRAIHSLGPWAGASLACHLKMAATATIDRDQWQQHGANGASRPSDVDTKAQQRHSGLLRSGGGGGGGGGGGGGGGGGHHGNWTLGVWGVIPSSAPKPILDTKHMRQNPELYERTCLDRKYQALAGNAGRIVDLHGQWLELRRMGSSLRHRVKLLGCLLSLEQAEAKAESEIESLALQLPNLTDTSTPPTRKITQHVNRHARPTKLESSTCTSSSPSPSPSPSHVEIGSRLGILDFASAASSTGWGWYYLVGQGSQLEQALIQFALSTASKHGYVPVSPPSLVYSHIGSACGFRPRDQNGEQQIYSVAQADEDVRRGVPARCLAATSEIALAAMKADSTLDYHHLPIRHVAVSRCYRAEAGARGADTRGLYRVHEFTKVELFAWLAPDDSVARTMLDDMVAIQLEILAKLGLYCRVVVMPPSDLGASATFKIDIEAYFPSRARRRSDDDDDDDDDGWGELTSASICTDYQTRRLATRVRLPADNNRLSFPYTLNATALAVPRVIAALLEYGWDEASGTVAVPECLRPWMDGRHRIGGPASSSSCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LD42</accession>
    <name>A0A367LD42_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LD42"/>
    <dbReference type="STRING" id="1330021.A0A367LD42"/>
    <dbReference type="OrthoDB" id="10257049at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08241">
        <property type="entry name" value="QOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051397">
        <property type="entry name" value="Zn-ADH-like_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677:SF4">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="11"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="335" mass="35464" checksum="284566DE851535DF" modified="2018-11-07" version="1">MRAIVLSEYVKHPSELKVSSSAPDPTPNPSQYLIQVHAAAANFFDILQIQGRYQNQPPFPWVAGSEFAGVVLKSPSKSSRFQPGDGVFGAAQGSFATRLCVGQDSLLPVPRGWSFADASGLFVTAPTSYTALVVRAGIAKGDWVLVHAAAGGVGLAAIQVAKALGATVIATASTDQKLSIASSYGADHVVSYTDANWPSRVKALTPSSRGVDIVFDPVGLVDKSTKCTAWNGRIVVVGFAAGSIEKLSLNKVLLKNIAVVGVFWGAYALNQPGLLPVVWEAVMRLIEDGKIRPTVFTDDSFWGLDSVKDALTALASRRTWGKVVINLAPEEASRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LD75</accession>
    <name>A0A367LD75_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3835 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_0212</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LD75"/>
    <dbReference type="STRING" id="1330021.A0A367LD75"/>
    <dbReference type="OrthoDB" id="21413at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019212">
        <property type="term" value="F:phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024325">
        <property type="entry name" value="DUF3835"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039553">
        <property type="entry name" value="Prefoldin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052255">
        <property type="entry name" value="RNA_pol_II_subunit5-mediator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15111">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT 5-MEDIATING PROTEIN NNX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15111:SF0">
        <property type="entry name" value="UNCONVENTIONAL PREFOLDIN RPB5 INTERACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12927">
        <property type="entry name" value="DUF3835"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13758">
        <property type="entry name" value="Prefoldin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3835" evidence="2">
        <location>
            <begin position="475"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="349"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI12361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="552" mass="60803" checksum="C4B13E9E949EF8F0" modified="2018-11-07" version="1">MAEAGDEPKIQNSIQHWLTWDAEYEALKEEVEAIPDNQPEELHRIHKNYEGDLLRHRELDDIFGLQAPRSKRQIVNVLQRRIDYVTQNLETLRKQLHAELSGVEGTAHDVEPNITDVVEQLDDDGNVVSFHLSRSGDALPQVCEALEKAGVDVLGGEKPSDTSSPLNPSKPQPTTPCASSSSSSSSSSTSPSAPTGNAKNAPPRPSTEMSPRAQRVDEIMNRARQQESISNQDPVIPVDEDSEDAQLRREMIQYGLRDVGAVVAELKLEEGEDSDFDEDMNDTDDDAEDRYGRSTGRLVSDDYRQRMLDLERKHGVKSRFTLSTDGDDRQSESGDDEGIGRIKVNCQVSPSASKSPPHKSSIKDKQSDAKKGVRFAQSLDVAPDDEPAASATEERAEPVADPLGDIVERAGPGDTIKPASKPRAPHRSSWFKQAREMEMAASSEAVPLGPLDAPSRLMDESMQDAPSWPQGSTVVEQLVEKEPSSSPCPPDELDDSMSCSSIADEHQRLRKRFIHRQGGFLQKDASPVEYLDGSEETAAPVSRFKAARLSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LD88</accession>
    <name>A0A367LD88_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Cytochrome c oxidase assembly protein COX20, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_0045</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the assembly of the cytochrome c oxidase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the COX20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LD88"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022533">
        <property type="entry name" value="Cox20"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31586:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX20, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31586">
        <property type="entry name" value="CYTOCHROME C OXIDASE PROTEIN 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12597">
        <property type="entry name" value="Cox20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007871">
        <property type="entry name" value="Cox20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="125"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR007871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI12380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="156" mass="17753" checksum="6863BE3A917CDD9D" modified="2018-11-07" version="1">MDRDKPNQTTLQSWPKPQPGIEPDSPLEVRSPTLSDAFATITKEDFLHVAKKPCAREGLLTGIAAGAGIGGLKFLLQGNVPKAANWAVGIFVVGSAASYEYCQFRRRAQRRTMMRRIEIVNEDRREKARKAAEERQTQLKLEEEDRKAQKPWYKIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LD89</accession>
    <name>A0A367LD89_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">NADH-cytochrome b5 reductase 2</fullName>
            <ecNumber evidence="4">1.6.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Mitochondrial cytochrome b reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">L249_1299</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">May mediate the reduction of outer membrane cytochrome b5.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>2 Fe(III)-[cytochrome b5] + NADH = 2 Fe(II)-[cytochrome b5] + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46680"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.2" evidence="4"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LD89"/>
    <dbReference type="STRING" id="1330021.A0A367LD89"/>
    <dbReference type="OrthoDB" id="19092at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090524">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NADH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06183">
        <property type="entry name" value="cyt_b5_reduct_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000032">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000009">
        <property type="entry name" value="NADH-cytochrome b5 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001834">
        <property type="entry name" value="CBR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19370:SF171">
        <property type="entry name" value="NADH-CYTOCHROME B5 REDUCTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 19" id="KW-0274">FAD</keyword>
    <keyword evidence="6 19" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="12" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 20" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="SH3" evidence="22">
        <location>
            <begin position="294"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="23">
        <location>
            <begin position="721"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="86"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="162"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="215"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="364"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="438"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="627"/>
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        </location>
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            <begin position="1"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="21">
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            <begin position="21"/>
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        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="21">
        <location>
            <begin position="49"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="21">
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            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="489"/>
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        </location>
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            <position position="775"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
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        <location>
            <position position="776"/>
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        <ligand>
            <name>FAD</name>
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        </ligand>
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        <location>
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    <evidence type="ECO:0000256" key="1">
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
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            <dbReference type="ARBA" id="ARBA00023002"/>
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            <dbReference type="ARBA" id="ARBA00023027"/>
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            <dbReference type="ARBA" id="ARBA00037464"/>
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            <dbReference type="ARBA" id="ARBA00039435"/>
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            <dbReference type="ARBA" id="ARBA00041256"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00047682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR601834-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="RCI12385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="974" mass="104899" checksum="4B43F841B8AF9F0B" modified="2018-11-07" version="1">MAMTETSYSTTSLPLDASVPPTHNQSLPTLTTLTASRRPWSVSYAPKNRLSQYQARSRPQSPVFPMQPSSSLYTLVRDFAYPVNHPMHYGPPPEPSGPPSDLNTPASEHTRLSDPPTSWDQLKPSDARAAADALSHANDIPPIQFGDGPPYSEDDDLQSPVVATRHRKHKSTASGASRPRTSSDLDHPSSNLMSSPAYNETVYFVGRNEDGSEQYYVSQGGEANGPGGGLVTYPPDQPRQSRSYHYAPDLRQAGSKEDYASGDSSCPSSPGYHEEDQSRYSRDYQFTITSPDEEFHGKAVALFDFERENENELPLVEGQIIWVSYRHGQGWLVAEDPKTQESGLVPEEYVRLLRDIEGGMNSLTGQVGDGVVSPTVEAGTPTQAEHGNKEGPQQAGSHAANGYHQPVVSVFSTSSKDLNPYPTEQLGIQAGQAPPQVIHYHGQRGGSQANTPTLAQHGEAGSARRGSQESGPKQEGDQVETSQETGSKAAATDDACTEDAAATTTTTTTTTTTEEAGSAEAKTDCNAGETTKSDRVSSRYMWAALNGLIRHKSKLEPMDVEKTGCHVMARDLTSYDYRGSLLIALAQRPSPPPSSPSSSILSPTSQFAMFTRTAFRAAQPLRTHARRYATTEPSAKKPSATTTTTTSSTSSENGGSSSQGKATNSSSPWLYLAGAAFAVGGCYWYMAGDSAAQKAAAKVKQATGSGGGGRATKAALTGGDQGFVSLKLTDVETVNHNTKRFRFELPEGDMVSGLHVASAVLTKFKGEGDEKPTVRPYTPVSDEDDQGHIDLLIKKYSGGPMSSYLHDMQPGQSLDFKGPLPKYPWSENKHEHIGLVAGGTGITPMYQLIRTIFSNPNDKTKVTLVFGNVSEEDILLRKELVELENTYPQRFRAFYVLDKAPKGKKWGGATGFITKDLLKSVLPEPKDGNIKVFVCGPPGLMKAVSGGKTSPKDQGELTGALKELGYSKDQVYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDC1</accession>
    <name>A0A367LDC1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">5-hydroxyisourate hydrolase</fullName>
            <shortName evidence="7">HIU hydrolase</shortName>
            <shortName evidence="7">HIUHase</shortName>
            <ecNumber evidence="7">3.5.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_0985</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23736"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18072"/>
            <dbReference type="ChEBI" id="CHEBI:58639"/>
            <dbReference type="EC" id="3.5.2.17"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4 7">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.17" evidence="7"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDC1"/>
    <dbReference type="STRING" id="1330021.A0A367LDC1"/>
    <dbReference type="OrthoDB" id="10265230at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033971">
        <property type="term" value="F:hydroxyisourate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.180">
        <property type="entry name" value="Transthyretin/hydroxyisourate hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014306">
        <property type="entry name" value="Hydroxyisourate_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023418">
        <property type="entry name" value="Thyroxine_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000895">
        <property type="entry name" value="Transthyretin/HIU_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023416">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036817">
        <property type="entry name" value="Transthyretin/HIU_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023419">
        <property type="entry name" value="Transthyretin_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02962">
        <property type="entry name" value="hdxy_isourate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395:SF7">
        <property type="entry name" value="5-HYDROXYISOURATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10395">
        <property type="entry name" value="URICASE AND TRANSTHYRETIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00576">
        <property type="entry name" value="Transthyretin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00189">
        <property type="entry name" value="TRNSTHYRETIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49472">
        <property type="entry name" value="Transthyretin (synonym: prealbumin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00768">
        <property type="entry name" value="TRANSTHYRETIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00769">
        <property type="entry name" value="TRANSTHYRETIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transthyretin/hydroxyisourate hydrolase" evidence="8">
        <location>
            <begin position="9"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI12433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="125" mass="13603" checksum="EC9ED6BF3C3295C5" modified="2018-11-07" version="1">MPAAAKDAITCHVLDTSAGHPAKGVRVRLEYAAVAFESLTDDDGRIAAWLPYSSAGEVPVYTLDDVLGSIDGPSKWTLRFDTDGYFGQANTFFPEAVVVFRVVPGQRYHVPLLLSPYGYTTYRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDI7</accession>
    <name>A0A367LDI7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0414</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDI7"/>
    <dbReference type="OrthoDB" id="4909128at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="87"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="124" mass="14410" checksum="84BE244DFFA5377F" modified="2018-11-07" version="1">MDSQAFRDGWNRLNAEFDEMVEPLRKQKDELITQLSQLSGKISEMDRLASAAERQRSAILFRRPLTREGRFQLHCLQEDMTVINSSLREFRISKESAESDLREVEAQITAARTRLARELSKLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDQ0</accession>
    <name>A0A367LDQ0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDQ0"/>
    <dbReference type="OrthoDB" id="5377213at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="389"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="475" mass="51073" checksum="D64C20D05B9C7828" modified="2018-11-07" version="1">MTSLQMRSAVVDQRTGVKVTKPRNLMVVKPLLKKLHSHDRDSLDLDRDWDHQPSSRHQQSFSDPYHYSYHSVSATPRSPRDLNFSLTPSDYGGAAAAAAAAAATAAAAAAAAAAAAATATTASGGTASGTGKGATRAHSFSHVRSASAASHASIATTNSGRNGGSFVHPFQQTPQGTALAYAHSRASLDIVRDCSPTITEDNDDDHDPYPALHSTTAPRPIIYQQPSQHHHRRPSLASQPPSPLWDANHASQRPSSGSVRRLASGSANQSRSELQLSAGASIVDSPLSATAPAVMSGTAATSPQIVPAPSCASSTGPMSPLRSSLDIGGFRLRSRSELDSATRKEHVREARRKFEEKERAKEEKYIRKQERANNKEVQKLEREQAKGFRNTSRTSHSSNTGSHGLPRTTAPTGLGVFEADEKSNSSRFRQPSQPRADDVDFDSAGRAKTAKHRTMGVWTAFMLWLRTRLLKLGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LE54</accession>
    <name>A0A367LE54_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP synthase subunit 9, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Lipid-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">L249_1255</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the ATPase C chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LE54"/>
    <dbReference type="STRING" id="1330021.A0A367LE54"/>
    <dbReference type="OrthoDB" id="438052at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033177">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, proton-transporting domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18182">
        <property type="entry name" value="ATP-synt_Fo_c_ATP5G3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.20.10:FF:000006">
        <property type="entry name" value="ATP synthase subunit 9, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.20.10">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01396">
        <property type="entry name" value="ATP_synth_c_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000454">
        <property type="entry name" value="ATP_synth_F0_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020537">
        <property type="entry name" value="ATP_synth_F0_csu_DDCD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038662">
        <property type="entry name" value="ATP_synth_F0_csu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031">
        <property type="entry name" value="ATP SYNTHASE LIPID-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10031:SF13">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00124">
        <property type="entry name" value="ATPASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00605">
        <property type="entry name" value="ATPASE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0138">CF(0)</keyword>
    <keyword evidence="9 17" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="12 17" id="KW-0406">Ion transport</keyword>
    <keyword evidence="13 17" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6 17" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="92"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="18">
        <location>
            <begin position="87"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RCI12703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="152" mass="15902" checksum="4E934699B34911C3" modified="2018-11-07" version="1">MAAPRVLASRLASQLVTKSARPALQQAPIGAVGRRTLTASATPLQALRRQQVNSLLKASRTNAFNSLQRRAYSSEIAQAMVEVSKNLGMGSAAIGLTGAGIGIGLVFAALLNAVARNPALRGQLFSYAILGFAFVEAIGLFDLMVALMAKFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEJ9</accession>
    <name>A0A367LEJ9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_0708</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LEJ9"/>
    <dbReference type="OrthoDB" id="60955at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061700">
        <property type="term" value="C:GATOR2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016239">
        <property type="term" value="P:positive regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12324">
        <property type="entry name" value="RRM_RBM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006846">
        <property type="entry name" value="Ribosomal_eS30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033744">
        <property type="entry name" value="RRM_RBM8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037590">
        <property type="entry name" value="WDR24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46200">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46200:SF1">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04758">
        <property type="entry name" value="Ribosomal_S30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 9" id="KW-0853">WD repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="97"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="401"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="588"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="768"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="853"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="889"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="980"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1189"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1389"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="624"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="980"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="996"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1021"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1401"/>
            <end position="1410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI12849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1410" mass="153417" checksum="B0ACFF19AB3C38B3" modified="2018-11-07" version="1">MGKVHGSLARAGKVKSQTPKVEPQEKPKMPKGRALKRLKYTRRFINVVLTGGKRKNKATMSMKSQMDVDQPTSPPVRNEAEMQTRTKATAVRSIEGWIIVVTNVHEEADEEALQDKFGEFGEIKNLHLNLDRRSGYVKGYALIEYTTLEEARAAIDGAHNTKLLDETVKVDFAFLLGKGAADSPAGDLASTLAPTTPRPSKSQNAVYAAGVPIGCLDAAPDRRAAVLGGPHILKTVVLDAGFGPADGVDIRAAIASRQRASDQLSIRDVKWHGHSTIFTACAGGRIFSYDLSRLGAEPLEAVQIHEDSRQVSSLDVNPHLRTWLLSGSHDGTARVFDTLKQVQSRTGVLTFCRRFGPLRCIDPVRQVRWSPRLGHEMACCTDAGVVLKWDVRQPSKPLLRINAHEKACVAIAWHPDGVHLLSAGWDTKLHVWDLGASADKRQRPKWSIAAPAPFAAAAWRPGLWSASSQTRRVAQVAVAYDETTNRRYGSSAVHIWDLARPTMPHKEVQRFDSSPTDLLWHDQHLLWTVGQDGLFNQCDVAFSPKVLDRQSPSAMAFSPRGDVVAFLDERPRLQRPRLSVVAEFGSDTPTLSVSRSDSDDDVMGPSLTGRRRTTIGLNRPSGRSAVQLSTTPPSGGFPDDAKQVLGLEQSIAMTGMFKLRQAMASGRTPTAKPVQLYHHLSTVYFETLARELPRAPDDGRSLAQRVGDIMEHYAQAAEGVSLFRLAQTWRILAHGMARLLNRRAQRHLERRVGHFQRTQADDVKVKVTPAYDGDGEDTPRRSSMQRVGDSRLPARSLLAEEIESTSNVPTPVARPADAHEQAAGIDNGKNGDDGYQYGKRLETIAEPDNLSIGPAAHAGLRPSPSDDRSHSPMTEGYDFYDAEALTKAIDVPAPRNSSSQRRRGTADQRQGLDEQMLAGAKRPMARSTSSSDVFAKPAIVRQTSDTDRSSTASSVEFEGSKVVMTMMVPDVDGLHPLVPTTGTQAADTSSKPGPVPTTTTAPTPKYDPTPHVIETDHLPWDDDDDGEVDNEDHRRRLHPRPPKALDPVSLVKRALDFEAKRSALHASAMVLLLKPLLPKTTIDEDQARAILRQQHDRLMHMSLFVEAALLRKLCVRGWPRGLPSWGSNYAAVFAPAQQGVKAALFCSGCRKPREVDPSAGEQAVWTCERCRLVMAPCAVCRHRQAERPAHVPEELSPSSSSSSSSAGGGGGDGDGADEDIVVRLSGWWICPACSHGGHASCLALWHADVLHGTYSDGCCPLDGCGHACLPGRYRGETASARADDLARAALEATRSRDDAALQQKTTIRLITIHVGSIAIDTASRHPTQTTGPKPLYAPPMPLRQVSRAGAADVEEILEVGQRVTDVDDAEALRGAEGLDVFVEEEPAVLESPLAGGGAASREVERELASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEQ8</accession>
    <name>A0A367LEQ8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosducin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_0766</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosducin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEQ8"/>
    <dbReference type="STRING" id="1330021.A0A367LEQ8"/>
    <dbReference type="OrthoDB" id="45518at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02988">
        <property type="entry name" value="Phd_like_VIAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037470">
        <property type="entry name" value="IVY1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024253">
        <property type="entry name" value="Phosducin_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38407">
        <property type="entry name" value="PROTEIN IVY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38407:SF1">
        <property type="entry name" value="PROTEIN IVY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02114">
        <property type="entry name" value="Phosducin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Phosducin" evidence="5">
        <location>
            <begin position="70"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="224"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="565"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="608"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1150"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1228"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="304"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1176"/>
            <end position="1206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI12909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1274" mass="138221" checksum="73EB85F2BAE7E91C" modified="2018-11-07" version="1">MAAPGDQRIAVPIDDPNADTENDILRKHGVIPEKPPSPTPMIEEAILEGRRLAHENRLEGKDLDELDELEDEEDEDFIEQYRQKRMAELRSLQNKSVHGSVCPISKPEYQRQVTDASRDGPVFVNLTSSMGTNAESARLSELWRQAAHEYGDVKFCEIRASQAIENYPDKNCPTILIYKNGDIVKQVVTLMTLGGVRTTMRSIDDLLVEVGAVSDSDMRVIKRRRAAEDEDEDEEEERQASRTIRTAKMPKIVRTPSTCSRLVGPRNPANGKALRTRSRVTSHPTRFLRLVASSPRSAMDEEPSLPQLPSSPSGTSTTPASSSDPLTFSSDDSPGLDNDVGGRRKRRYLGPWFKQQPASSDSALEDVVPQPSKRTLTRHIDSGVFCGSDVSEDYDLPDPACIPSRVRFLPFLPERRVSPAEQLARDRIRECVDMGRERVDLMNIDLESIDDHTIGLLSTMQVIPNVSRDVAFVQQEPQIDLFLGQNSLTRLPGALFRLTHLTTLSLRGNGLTEISPAIANLTNLKELNLAQNKLRSLPSELLRLLGLNSNLQRFFWGPNPLYEPDGELQPNDAATPRESGSSGHYSTRYLGRSPLQLSSSMGRVTSRFRLPSSHDMQTRVPTHGPSGGDKSCGGAGSNVASLVELCLRSGYSSGELPELHEKMPKQMEVLRRLLQRAATQKGAGGLSCSKCRRLVIVPTVEWIEWHEISGRGEATAELPAVAFQHRACSVPCLQRPLRLRIESSTASLSLVASPRKTRLDAHESPCLFLFFVFVLLPTNSLGMICPPLPAISRSPDSEVAAVPGGYQATEDSLPSPSQLPPVPSSPVYSVASTAQSGVGAVGGGGSQFSLPAPPAPRPAHAVLAKADLERSQEAYADLVASAKSYRLALASLSSAASAFAAALEACARLKEARADLIGPISASNPSASSSSSSSSSSAAAAAAAAAVATASSAATSSSTGRGCTADPLLSASGVHHLIANHQQILSETVYRAFEVPLLHDLDRWRSVIEDEEATYQHSITAQSREVKRLEREGLKLHRQRRRDVGRFRAHLVDLTAKLDGLTTLHADHARSLLRESQETSTRIVDASCSLVRAEVDIFESLARKGWSGGGLDDLLDRGRDLFAADDAVAHPVPDPAKLFSILPPKSILPDSSDSLLPAMNTYSSSNDDDEHDEYRSSSSLSSSSATSTATITTAAAEASRPRNNPRPFSPQPIRRIPTDVTFDSLAALAVPGPAAPPSQRRADEDDEDDEDVLRGRALSYRQIGTVEEESGADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFN9</accession>
    <name>A0A367LFN9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_1171</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFN9"/>
    <dbReference type="OrthoDB" id="630188at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07379">
        <property type="entry name" value="MPP_239FB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051693">
        <property type="entry name" value="UPF0046_metallophosphoest"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12905:SF16">
        <property type="entry name" value="SER_THR PROTEIN PHOSPHATASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G06000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="5"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI13207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="315" mass="34554" checksum="627CEC7712A7A811" modified="2018-11-07" version="1">MPRTRIVCVSDTHNCAASIKLPPGDVLVHAGDLTNQGSRSEKRIICSTSPLLPWPQLSRAVSWLEAADFEAKIVIAGNHDITLDSAFYAEHGHVFHNQRPESPTVCRELFTSSPSLTYLAHESATIRLPSRGVEFSVFGSPYSPRRGGLWAFGYDEDSSPWDAIPSGTDIVVTHTPPRTHCDMEDGGGQPAGCEALRRALYRVRPRLAVCGHIHDGRGVEHVSWEGEKEGDEASSSSSFTRRTWNDPGAGNKKLSLVHLDGMGETCIVNAAMMKSRRPHVGGKQFHKPIVVDVDLPPWRREGGVSDDEPRHEAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFR3</accession>
    <name>A0A367LFR3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_0783</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFR3"/>
    <dbReference type="STRING" id="1330021.A0A367LFR3"/>
    <dbReference type="OrthoDB" id="5409308at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018450">
        <property type="entry name" value="Romo1/Mgr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28525">
        <property type="entry name" value="REACTIVE OXYGEN SPECIES MODULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28525:SF1">
        <property type="entry name" value="REACTIVE OXYGEN SPECIES MODULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10247">
        <property type="entry name" value="Romo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01378">
        <property type="entry name" value="Romo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI13260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="137" mass="14999" checksum="FF7E44941F595DE0" modified="2018-11-07" version="1" fragment="single">KRTLTPGNDASPPGFLRWRTSWAVQLGKAADGCLDGRKYDAVNSCVHQTTDALKAVGVIIGFIYGTVNIFRYGAGSQGVMRTLGQYMGASGATFGFFMSIGSVIRSDVDPKKMQELYLRAQQRRPIFVLAESGWRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFV0</accession>
    <name>A0A367LFV0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFV0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="79" mass="8118" checksum="651E02427BB90110" modified="2018-11-07" version="1" fragment="single">STRLAKGTVGSDGRAGCHDSEWTMSKTIEDTLVSFGGEEGKGRTKTGRALAFSPTFGRWEKGGGRREGGGVGNGGAGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LG16</accession>
    <name>A0A367LG16_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_1019</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LG16"/>
    <dbReference type="STRING" id="1330021.A0A367LG16"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053025">
        <property type="entry name" value="Mito_ATP_Synthase-Asso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44873">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 30, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44873:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 30, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="29"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="162"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI13365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="281" mass="30859" checksum="5E36F13483051E51" modified="2018-11-07" version="1">MLHAFPTRNIHASRTLFHTGGGGGGGGGDLYARLRVRRDASTAEIKSRSFYALSKTLHPDVNRSDPNASTTFSLLADAYAILASPSRRAAYDRTLSPASHSPPSSPASPGPQPSYAAGRRRSTPFRGPAPSFYRNGGWGAHAAARRRAHEESTGFAARSRSRPTQGSSPSSSSRSPPQADDHHPRRHPGMGPGQYPFHHARDPAPDPHFNLDGHTRTHQREDERRRQRNRRAVDDEGIEFEPQMSLAGHFFVVATILGVTFASPFVYLQYTPFGFRQREGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGI4</accession>
    <name>A0A367LGI4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGI4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="77" mass="7965" checksum="F39589FADF202494" modified="2018-11-07" version="1" fragment="single">TLTYFGGSARHSHTHTQGTRPEGLGGSRDAGPAAAGPRPPYVTAAERHNNVGGGYGTATPTAQARRAFFSNTISLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGQ2</accession>
    <name>A0A367LGQ2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">2-(3-amino-3-carboxypropyl)histidine synthase subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_5561</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the DPH1/DPH2 family. DPH2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGQ2"/>
    <dbReference type="STRING" id="1330021.A0A367LGQ2"/>
    <dbReference type="OrthoDB" id="449241at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11840:FF:000002">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010014">
        <property type="entry name" value="DHP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00272">
        <property type="entry name" value="DPH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF2">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01121">
        <property type="entry name" value="Diphthamide_biosynthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00408">
        <property type="entry name" value="Diphthamide_biosynthesis_famil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="397"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="440"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI13613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="511" mass="55067" checksum="A4E7C9615415CF35" modified="2018-11-07" version="1">MTVPLTAPPQLSTPDDGALRQQPPAPAAATASRPRASSETLRTTYETARTAAEIHTGGWTCVALQFPDDMLGDAPRVVDLLRRELPPSARIHVLADTSYSACCVDEVAAEHVDADVVVHYGRACLSPTTRLPVIYVYTSHPLDHEAVFRKLERALDGGRGDQDKATVKAIVMADLMFQDHVDGLVRRLHAAGYDGVVATQVVRDPVAVIPNRKLPLRDDEKAAYSLFHLGDPPQSLLLALHSRFASLHVLATPAPGSASPPSRSIVVDNDAAARTAGLLRRRYARVLTLASAGVIGILVNTLSVGNYLSSLDLLRRKIAKAGKKSYTVVVGKLNPAKLANFAEIDGWVAVGCWESGLVEDDAAYWRPVVTPFELEVALTREDRRTWGGEWWGGIEKLRPLDDEGDDDSAASDDNKTETDEEESLPPEFDLRTGRLVSHSRPMRQGRRSGPHRAGDSTAVAMRCAGQIASIGGVASPGAEFLRAGRTWQGLGSDFDPEASTALVEVPLAPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHG9</accession>
    <name>A0A367LHG9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHG9"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="106" mass="11936" checksum="8B9DFC0266E2D18B" modified="2018-11-07" version="1">MGGILLDKSENRLHVMSRYVRALYQGKFIVNRGRRGGVPGTCTQTDKTWLQRDIMSGANDGAFQSAWAAGWAAKGEGSRCSREKSGRTEERERETDRQTRQTDELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHM5</accession>
    <name>A0A367LHM5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_8202</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHM5"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI13899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="172" mass="19013" checksum="70479021612A2993" modified="2018-11-07" version="1">MDDGYHRHESDRAHLLVLPALGPGWAQVGGYTLGLGSIALHHFAFVHVADTTKQTVDSSSSFVFLPQERLPVHLRIPARCSSLTPHSSFSGRCWVRMPPANRSPTRHTAGPALQAWTSGDALRPVIVACLSRPWCAAEWLDQVIHLSWARLPSSRWVYLVVHGSLIGDDPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHT1</accession>
    <name>A0A367LHT1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Deoxyhypusine hydroxylase</fullName>
            <shortName evidence="9">DOHH</shortName>
            <ecNumber evidence="9">1.14.99.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Deoxyhypusine dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Deoxyhypusine monooxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LIA1</name>
        <name evidence="11" type="ORF">L249_8049</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[eIF5A protein]-deoxyhypusine + AH2 + O2 = [eIF5A protein]-hypusine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:14101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="Rhea" id="RHEA-COMP:12592"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="ChEBI" id="CHEBI:91175"/>
            <dbReference type="EC" id="1.14.99.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the deoxyhypusine hydroxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.29" evidence="9"/>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHT1"/>
    <dbReference type="STRING" id="1330021.A0A367LHT1"/>
    <dbReference type="OrthoDB" id="421002at2759"/>
    <dbReference type="UniPathway" id="UPA00354"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019135">
        <property type="term" value="F:deoxyhypusine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03101">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027517">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697:SF5">
        <property type="entry name" value="DEOXYHYPUSINE HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697">
        <property type="entry name" value="PBS LYASE HEAT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI13985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="321" mass="35131" checksum="A89CD98D4BE3FA59" modified="2018-11-07" version="1">MADASIQSLRESLCSESTPLPVRFRALFSLKHVARTSQGQPAVAAIDAISAGFKSPSALLKHELAYCLGQTGNDAAIEPLRKVLSDLQEDPMCRHEAAEALGALGKMDNLSLLQHFRDREGEDVVVKETCEIAIDRIRWENSEERSQEKLRQSEFASVDPAPPMPESGKTVYDLSKQLLDVNSPLFLRYRAMFALRDLASQPDAPTTVPAVLALAEGFRDKSALFRHEIAFVFGQLSHPASIPALTAALSDVDEASMVRHEAAEALGSLGSEDGVEEILKRFLEDKEKVVRESVIVALDMADYEKSADAEYALIPETASVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHZ4</accession>
    <name>A0A367LHZ4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal peptidase complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_8031</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI14045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHZ4"/>
    <dbReference type="STRING" id="1330021.A0A367LHZ4"/>
    <dbReference type="OrthoDB" id="29558at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009582">
        <property type="entry name" value="Spc2/SPCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 25 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06703">
        <property type="entry name" value="SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="203"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI14045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="227" mass="24423" checksum="4CF2A9F029C3A713" modified="2018-11-07" version="1">MASPEKISVYNLANTSDDALPNYLNSLRFKQSHFLTDVRLALGYGAFAIAAAAFLWDYRFGFDDTKLYTSVAVAVYAVVNSALTFWLTRVEKGVVYQGVSPSGDELSIATATTRNDPTYRLTISVNSRGKDPQVINLAAPFASFFDETGRFVVKPFQELLASSVPVIGKLDPKRASSINNNKLASQDLLNADPGLLDAVLAAEPATATTSSSADAKTGGKRRKSAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LII7</accession>
    <name>A0A367LII7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LII7"/>
    <dbReference type="STRING" id="1330021.A0A367LII7"/>
    <dbReference type="OrthoDB" id="2420947at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025212">
        <property type="entry name" value="CAD_CENP-Q"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13094">
        <property type="entry name" value="CENP-Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00929">
        <property type="entry name" value="ATHOOK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="378"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="768" mass="86558" checksum="F6E9B94A1C1314DE" modified="2018-11-07" version="1">MDPSAKRKRGRPPKQRREDALLAVDDGDGERPSKRGKVVEAETTPPSQPRKKGRPPRKSLIEVILPSQKRVDEEQERAQQQLEAEKQQQQQLEAEKLQQQQKQLEKQQEKQRREVEHRQRELDQRQKKKREKQKHQEEEQQSKREQQQKDEQQDEIRQPPVAVDAQPRRRRGRPSLQKRPSEQAVETEARQTRDQPPPPTTPDEQVPTKPRKRGRPPLQKSEQAVETEARQTRDQPLPPTTPDEQVPRKPRKRGRPPLQKSEQAVETEARQTRDQPLPPTTPDEQVPTKPRKRGRPPLQKSEQAVETEARQTRNQPPPPTTPDEQVSTKPRKRGRPPLQKRPSEQAVETEARQTRNQPPPPTTPDEQVPTKPRKRGRPSLQKQPSSSSPVPTPKPNGENGQSLNKKGRRARQDREPEAEAEAEAEDDAEAEDDAEAEAEAEADAEADAEAEAEAEDDAEAETDTEAELEADAAAEADADAEAELEAEGDEVERMPRRRRKKDEEATAAVATKSSLKPYPRVVSHVRHVRQSIINAKWTPLTAPSLAVVQTMLSLAQQPIVQHLSGANRRRAYASDVLRVMSRRISRKVARGLPFPPALMAAPARGQQASDGGRESELNFESVLDAKSVLEAQLEPAAHAVELLRREKLRVEKELEKDYEALKALEMAARAQAREHRGLLKKAHLLAPQTGPQKETRLIVSPASAPADDVFTDLEDDDVTQLAGHVDSMRVNMQQVDGLVPHLSRGRAALQAVLLRHLSSDQYERVVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIV2</accession>
    <name>A0A367LIV2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_6006</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIV2"/>
    <dbReference type="STRING" id="1330021.A0A367LIV2"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="163" mass="18706" checksum="B34E741C498B8C31" modified="2018-11-07" version="1" fragment="single">NPAYSNSAKTRYKDIRTFSRKKGEFSAFLTNLKDKIRTNKATFRDKEDRIGFLFRSLEGKARKTLETWYDSIERPFSRLAEIIYLLTKTKDDSLFYKDFCGYVKDSAVKRLDAELVLVSPVPLVDFQGRLASSPNDLPALAKYSLSILLPKTPLLNRQIDLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJJ7</accession>
    <name>A0A367LJJ7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Conserved oligomeric Golgi complex subunit 4</fullName>
            <ecNumber evidence="4">7.2.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Component of oligomeric Golgi complex 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">L249_6831</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the COG4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="4"/>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LJJ7"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000040">
        <property type="entry name" value="Calcium-transporting ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000083">
        <property type="entry name" value="Sodium/potassium-transporting ATPase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048682">
        <property type="entry name" value="COG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048684">
        <property type="entry name" value="COG4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013167">
        <property type="entry name" value="COG4_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048680">
        <property type="entry name" value="COG4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20662">
        <property type="entry name" value="COG4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08318">
        <property type="entry name" value="COG4_m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20663">
        <property type="entry name" value="COG4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00762">
        <property type="entry name" value="Cog4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="15" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="906"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="940"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="977"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="21">
        <location>
            <begin position="59"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="COG4 transport protein middle alpha-helical bundle" evidence="20">
        <location>
            <begin position="1214"/>
            <end position="1556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="23"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="621"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1376"/>
            <end position="1400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="RCI14606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1826" mass="197945" checksum="1B098C14B1745ECC" modified="2018-11-07" version="1">MQLLWKGAQSSANESLLPMSSLPTITNCSKDSPAADGSPAVRPRHARTSSAQARSVAEGFASMTSTDTAAELRTSLTHGLSPTEALTRLGQYGPNEIPHEPPEPLWLRFVKQFQEPLIMLLLVSAAASVLLGNMDDAISITVAVTIVVTVGFVQEYRSESSIEALNHLVPNYAHLEETDEADGSGADMSMDDVLDATSTKVMAAQLVPGDLVLFTTGDRIPADIRVTKSSDLSIDQSNLTGETEPVRITSEARSRRANALGISHAQFPRPQSLAPGDGLEAEGGADSHNIAYMGTLVKSGYGQGIVFATGGSTHFGTIATSVSGTESPRSPLQLSMDELGSQLSKASFVVIGLISLVGWMQGKGLLDIFTISISLAVAAIPEGLPIIVTVTLALGVHRMARHNAIVRRMPKVETLGSVNVVCTDKTGKFGSPSPLWYFGAGGTLDVASDSETIETKLSQAYMRILRIGNVANNARLARNYTENGVAATAVLSSTLGRDQAAPYSRWVGQPTDVAMLDLMDRFKEHDVRESLGPRVSETPFSSARKWMGVTIGSDVRSEKEYSYMKGAVEKVLAACNTYLDRDAREVVLDAARRREALDAAESMAAKGLRVLAFASGPVARASKGRQSSGVPRSGTPGSELGTGSPVRTSVDSFEDLTFAGLVGMSDPPRPGVGRSIRRLMRGGVKVIMITGDAETTALAIGKQLGMIIAAPSAHSAGQNAIKSVLSGHEVDVMSDEGLAQALQHTTIFARTNPDHKLKIIRALQSRGDIVAMTGDGVNDAPALKRADIGISMGRHGTDVAKEASDMILTDDDFSTILRAIEEGKGIFNNIQNFLTFQLSTSAASLSLVFLCTCFGFKTPLNAMQILWINIIMDGPPAQSLGVEKVDADVMNRPPRKRNDQVLTRALLTRVLTSAFIIMVGTMLVYRHEMLADGQVTRRDTTMTFTCFVFFDMFNALSCRSESKSVLRGEVGLLANNLFNWAVSLSVLCQLLVIYLPWLQEVFQTEAIAIGDLVRLVLLCSSVFWVDELRKYLRIGRVSSEGLPRSPMSKAAGLIQEADSETELRAALAGLHRGEAALQSRLDALLASKADLSRDLGRLDVLRASLGAQVVAARSIGSEMLASAAETAGRLSDRVKRLDLEKSRVEETLEVVEQVAELKACVNGVVGSMGAPQDWEAAAGYLSRAAKIPEDIAKGAFATSIVPSVEVPDPPWVTLESARESLCGLFLREFDKAAGEGDGAKVTRFFKLFPLIGRADVGLDVYGRYVCQGVAGSARATLRDVGGSQSRNEGFFYANALTKLFEHIAQIVDGHGALIERHYGAGKMVRVIERLQAEADVQGGIILDTWSDERAVDRKLTDVKSYPFSFLVQSFLPQPGRGVPSRGGSPAVGAGTNARSSEDEGVNMKEVDALLSEMALMLGRWSLYARFLSGKCMEPGTEDDGRLAIADVIVKSNLYRKTSNKLTTPYNVMTTFFFRRSVEKAFQLDEYPRGLSLSMKKPLEGNAPYIILAVDDVMYMADAVIQRSLSTSQRDVTASVIPTVGRVLGSEFIGMIQRKMRDESYPRSAVQGALPPEDKIVQFIVLINSLDMANEYLDRIISSRVVSADGDVTLQEPVKKLFPFERDVAFVANALLTLETRFIAKSTELLNEGIQVLFNQVVKLRLRAVLSETFRDADYSMTEEEVLELAQQNDESEEEALGQVRRRFELGWDQLMRPMARLMTGKMYGSLLEMTARHLSRVLEKRVLGHGGKMAAFGAVRIERDLGAIVEAVSRGHYGVRDGFARLTQLLMVANMEEEEWEELEREASGGTEWIVTKEERKRARGLVGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LK64</accession>
    <name>A0A367LK64_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LK64"/>
    <dbReference type="STRING" id="1330021.A0A367LK64"/>
    <dbReference type="OrthoDB" id="3439209at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="259"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="481" mass="53746" checksum="95B6854BDEA83614" modified="2018-11-07" version="1">MSYRLGLMDIYEPSFELCFSDDPFQDDLLSAMSTSTQHAWVSLIFVFFPLLILESTPCLLPSSLLMKKDASIFDMPSTESHHHHHHHHQQHHQHHHQHHHPPPLPLPPPPPPPPIEPQSQQHSPFDAIDSGGECTSLTPKLVDLNLNSGSQWAAMPYLDPDVGLIPLDLPYDGLQPWQEAAHVPQGLEIADAAEEVIDCAMPDHPCHASEMQQQRARDFWSETETISSEPMFKPIIPLTPPASEGSLLIVSPGELSSATGSPTTTIFTETSEEEATSPSVSERKKLPDIATHQCDGAAAAAAASSSSSSCSVDTAPCFLSKRKTDKLAVRRKQRRRVTPSSNDTWSEGQTSSPPFRKIDQMDPLSRQLLDEMLLNDRMPPIGKPIPYSVIMVRLRHLYCGAEETLRGHFRRLTKPKEQRVRKPVWKDNDVRLLEEAVKLYLDATTKRKISWTAVGEYIFSHGGSYKFGVTACSKKWYSLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKD1</accession>
    <name>A0A367LKD1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="1">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_6992</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="1"/>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKD1"/>
    <dbReference type="STRING" id="1330021.A0A367LKD1"/>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08598">
        <property type="entry name" value="PI-PLC1c_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF169">
        <property type="entry name" value="PHOSPHOINOSITIDE PHOSPHOLIPASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="3">
        <location>
            <begin position="298"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="16"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI14888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="582" mass="64085" checksum="A9B2C0E2CD94C512" modified="2018-11-07" version="1">MTDLASRIGRLKPFNHIKSDDDSVGEDDYDDIDDAGEVTGEDAVGGGGRYRRNADHHQQELRVGDALQSLLVHRGVLPDDDDGRDEALGRLLDQNACCVPDHLLDCSHSLPDYFISSSHNTYLLAHQLYGTSSAAAYKTTLRMGSRCVEIDAWDNAADEDEPKVTHGYTLVSHVPFRAVCEAIRDIYDEEAALAESDPSFPVAPILLSLENHCKEHGQRRLVAIMRQVFGSRLLSEALCHDAPADRYASPAEIGPRISVIVEFHLPGADEAECSSCSEGEEAESGQAQGGGVIIVPELAELGVYAQSVKPVNASWYDPGELLNGPHHHLVNISETGLSKNLPTHAEPIALHNARHMMRVYPKGTRISSSNLKPVAYWGIGAQICALNWQTFGTGNLLNDALFNGSNGYVLKPAALRNGGSGSVGSGRWRKLRLYVAGATDVPLPSGREVDSIKPYLTCRLYSPCPVDGSSDKRKTSAYRQHRLGFLHRGENPPNTDPIWDETLEWSYEDNELVFLRLLVKSDDAWARNPAFAAAAVRLHYAEPDWCFVRMMDMKGRETDCTVLVKFAFEDDDDDDDDDDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKH6</accession>
    <name>A0A367LKH6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_6575</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKH6"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="78" mass="8812" checksum="FB393EB8F1D02AE6" modified="2018-11-07" version="1">MFLKMKPKDFHLALITTLSPTAIQSIDEQLNGLLPRTRSKLLCVTTRGQKGTKTQIKSHPPPYLVLLARDAKPMRRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKQ4</accession>
    <name>A0A367LKQ4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7066</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKQ4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI15016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="62" mass="7210" checksum="370BE854293F3568" modified="2018-11-07" version="1" fragment="single">IQKVIQAVDKELTNREGDHVIEKKKRNHVITCTCRSDRSDRSDPMIPAMTAMTRPLWSLLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LL10</accession>
    <name>A0A367LL10_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cytosolic Fe-S cluster assembly factor NAR1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Cytosolic Fe-S cluster assembly factor nar1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Nuclear architecture-related protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_6820</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the cytosolic Fe/S protein assembly machinery. Required for maturation of extramitochondrial Fe/S proteins. May play a role in the transfer of pre-assembled Fe/S clusters to target apoproteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NARF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LL10"/>
    <dbReference type="STRING" id="1330021.A0A367LL10"/>
    <dbReference type="OrthoDB" id="10253113at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000042">
        <property type="entry name" value="Cytosolic Fe-S cluster assembly factor NAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1780:FF:000004">
        <property type="entry name" value="Cytosolic Fe-S cluster assembly factor nar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.950.10">
        <property type="entry name" value="Fe-only Hydrogenase (Larger Subunit), Chain L, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050340">
        <property type="entry name" value="Cytosolic_Fe-S_CAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009016">
        <property type="entry name" value="Fe_hydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004108">
        <property type="entry name" value="Fe_hydrogenase_lsu_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11615">
        <property type="entry name" value="NITRATE, FORMATE, IRON DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02906">
        <property type="entry name" value="Fe_hyd_lg_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53920">
        <property type="entry name" value="Fe-only hydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iron hydrogenase large subunit C-terminal" evidence="10">
        <location>
            <begin position="121"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI15099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="583" mass="62051" checksum="B31E8786277A8C3A" modified="2018-11-07" version="1">MSAILSADDLNDFISPGVACIKPVETLPPVKKKEGGDDEVVLDGPLHQHHPPPPAHISLTDCLACSGCVTSAEAVLVSLQSHAEVLATLDAAPALRLDGKVDADAVPSVVGLENPESRVLVASVSPQSCASLAAAAGVGQDEARRMLDALLRGPDGLAASGKWHNSFAWLLDTDVVAEAGLVLAAEEALASTPADKASPTRPVLAASCPGWVCYAEKTHPHVLPHLSRVKSPQALMGTLLKTVLSRRLRIPPSRIWHMAVMPCFDKKLEASRGELTDVGWAGDGSSSGDAVRDVDCVITSKEVLMLCESRGIDFFSLPRDSSSSSSSSIPPPPPFPDSIIHDFLFPAAGGSRRPPRAAGSSGGLLHHILRVRAAQSPRAEIHMTRGRNADVVEYSVNLDGEPLFRAARYYGFRNIQNLVRKLKPARPSRMPGGKPFGGVRRPVGKPAPLEYGYVEVMACPGGCTNGGGQIKVDDPVVAERKGLVRKAGPQEHKEWLAEVDEAYFSRSEAEMDNGGRDRHGDVPDGISASHIHNILSHWSVLTGITLERLAFTSYREVESDVGRDQTTNADKVVQLAGKIGGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LM59</accession>
    <name>A0A367LM59_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_6731</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LM59"/>
    <dbReference type="STRING" id="1330021.A0A367LM59"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF15">
        <property type="entry name" value="GENERAL AMINO ACID PERMEASE AGP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="428"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="466"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="512"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="56"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI15342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="581" mass="63507" checksum="EC8A735686678204" modified="2018-11-07" version="1">MGSTGVTAPAPPSYPASGHDDGPRPGKGERPAQSIRESLSDGAGADATHRKLKSRHVQLLGIGGSVGTVLFVQIGKGLIDGGPGSLFLAFAFWCTFILAVTQCMAEMVTYLPISSPFIRFAGRYVDDAFGFAAGWNFFIFQAALVPFEVVACNLIIRFWTAAIPTVVIIVTIITLYALLNVLTVSWFGESEFWAAVGKVILAVGLIIFTVVVMLGGNPGGDRFGFTFWKRPGAFAELYYPGALGRWLGFLQCMIQAAFTIAGPDYVSMTAGEAQNPRTVLPRAYDAVFYRLTAFFVLGSLCVGILVPYDDAEMRAALANSVSGAAASPYVVAMNRLGIRVLPHIVNAMILTSAFSAGNSYLYCASRSLYGLALEGKAPKFLTVCTSKGVPVYCVAIVLLFALLAFLQLHTSSAVVLSWLVSLNTASQLINFSMVCVTYLFFYRALQAQGISRRHLPYRARLMPFAAWYALAGTVIMALVGGYKVFLPLPGFWNVPDFLFSYVKTWPFLDLGMLTHLSLSYAMVAMFPILYFAWKFTHKTSVYKPEEVDLFKDLAAVDEYERQYIPQPPRNQAEKVLDKMFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LME2</accession>
    <name>A0A367LME2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LME2"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="84" mass="9607" checksum="694036FA58F2A397" modified="2018-11-07" version="1">MSQGSPSDRSRLDGILSVVVSDRCKAQRIDPRPVGRHGMPYSQMLGGHEKDIRGNEGKSHAGMKQIRMYVYIIWGWDECNEFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMR8</accession>
    <name>A0A367LMR8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 16">ADP-ribosylation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L249_3476</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="function">
        <text evidence="16">GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMR8"/>
    <dbReference type="STRING" id="1330021.A0A367LMR8"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04150">
        <property type="entry name" value="Arf1_5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003500">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045872">
        <property type="entry name" value="Arf1-5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 16" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 13 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10 16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 16" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 13 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 16" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="27"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="129"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU369003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCI15708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="186" mass="21228" checksum="8DAA2DCE9EB072A6" modified="2018-11-07" version="1">MGIKLSKITGLFEQLWGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNIQFTVWDVGGQDKIRPLWRHYFQNTQGIIFVVDSNDRDRIVEAREELQRMLNEDELRDAILLVFANKQDLPNAMNAAEITDKLGLHSLRQRAWYIQSTCATSGDGLYEGLEWLATSLRKAGHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNZ9</accession>
    <name>A0A367LNZ9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_3268</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNZ9"/>
    <dbReference type="STRING" id="1330021.A0A367LNZ9"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16464">
        <property type="entry name" value="RING-H2_Pirh2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039512">
        <property type="entry name" value="RCHY1_zinc-ribbon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008913">
        <property type="entry name" value="Znf_CHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037274">
        <property type="entry name" value="Znf_CHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017921">
        <property type="entry name" value="Znf_CTCHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037275">
        <property type="entry name" value="Znf_CTCHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21319:SF0">
        <property type="entry name" value="AND RING FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G08900)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21319">
        <property type="entry name" value="RING FINGER AND CHY ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05495">
        <property type="entry name" value="zf-CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14599">
        <property type="entry name" value="zinc_ribbon_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161219">
        <property type="entry name" value="CHY zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161245">
        <property type="entry name" value="Zinc hairpin stack"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51266">
        <property type="entry name" value="ZF_CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51270">
        <property type="entry name" value="ZF_CTCHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHY-type" evidence="7">
        <location>
            <begin position="329"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="CTCHY-type" evidence="8">
        <location>
            <begin position="398"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="465"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="76"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="150"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="583"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="664"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="76"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="670"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI16117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="702" mass="77919" checksum="531B9CC6FB6C2E7A" modified="2018-11-07" version="1">MPLTTYRYEYSAGKGCWPVPAYVIGSPMRQRPHAFLVARSHSSPSSGPLLPRPARRIGRSVARLIGRRRSSPFVAVVRRPSSSSSSPRPQLAQRQIPSVPSSQHRPMSSLVSDFILNPVLRQARRFSEISRSTLTGDDEHAAIREVVSDTQQREALCRPSTTSANTDDVKVDDSTANDAVTADNSTESHLLADATMSDNIATDSALMANPGRGIPEDDGMRHLRRRIQAINARDIASSQKARLMHETLLEPYRASQAAALRDGSRDVEPAAQTWEHRTSPRPLDPLRFWYADTPKFVLSESDVAPTYAPIRQPKSSGGSTPTILPTPADLSPPLGCQHYERNVKLQCSTCFKWYTCRFCHDAREEHSLIRRETRHMLCMLCGTPQRASDVCVNCGETAAQYYCNICKLWENRQSKPIYHCTDCGICRRGLGLGKDFFHCKTCRACITTSIQSSHKCIERSTDCDCPICGDYMFTSPKPVVFMSCGHSIHKKCYEQHMRESYKCPICNKSLANMETHFRNLDVAIQSQPMPPEFHNSQVTVLCNDCSGRSTVAYHWLGLKCSICRSYNTVELQMRDESHQVPATVESMEPPAAAGSGQDVTRSAPAGGTLLVNRRRLSSHNGDPVIRLTGRVARPRSPLGTAMDHLCLTPMTTDAESEDDILGFWGGTLAEGDESGESDSDQDEDTGDDEEDDEDEIILIGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPA3</accession>
    <name>A0A367LPA3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_3186</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPA3"/>
    <dbReference type="STRING" id="1330021.A0A367LPA3"/>
    <dbReference type="OrthoDB" id="4655872at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="2">
        <location>
            <begin position="18"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI16263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="432" mass="48893" checksum="0ED5AEA7B8097A55" modified="2018-11-07" version="1">MMSSPAIKFDVPVGCRTFTLFPRLPLELRHRIWQAYLGSEQGANFVKFHVADEGHEQALRPDQLDSPDNAADEPDDVIRLLMQHDAVPRGVVDCILGASYPDPVAEVSHHALLRRRLAIMRSTCKESRTFVHSLLRRSGVLRLDSGTVVSLDRSPDLLILDYYPQELYRRNDTLDVDLYCPRLDTVRRLAVRFCPTWRPETILERMCSCGKHREVDAGNYPTHLYQFLARNLPNLREFYLIDYFIVPKEGEEIKCLDRADSRTSHVFRSRDRIFHDVAHCHPSTGTWKINPKSGKILDWLRDHYVRYASQSTTSRHETPLQVYFGLLACEWKISSPTARRPRTPHGRGRGTRFSEKHVEDRKQSPAMRQAPTGSASRSPSGGPEAMDTGPDGGAERSGTQAASGLSSSVFVFGSGCGDGYEFTFSQPYEVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPG3</accession>
    <name>A0A367LPG3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peroxin 26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_2173</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPG3"/>
    <dbReference type="STRING" id="1330021.A0A367LPG3"/>
    <dbReference type="OrthoDB" id="3981028at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI16281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="442" mass="49192" checksum="05174B713EF90910" modified="2018-11-07" version="1">MSSVDGIPGFDHTLDDSFPRSLLSSSFSAYSVGSTSASSTAARRSSHVSKTYRQASTLFLTRRLPEALTTLTPLIVPAEDGEPAPVAKASRTTRIKVWSLYLTILHAVVEMEAGDGKEAFGNQEWRTLCAKVRDGLVWEEVVRDGYHGVEGDVDSDVVINLATLLLAHARDQTLNQRRLETYLATSNTPDLDLGRQIDKSPVPRSHSGPRYRSPAPGTSGADTPRDLNARVKILELYTLHVLLRNNEWDYAREFISVSSVLDDERREAFLQALESLQEEQQEQERLERAERRRQEEQLRRQIDDARRLRAENEEWERRRQDEARRNEADHGVERSRNSDSARSQQQRTSRIAGSSSAGKPAVPPTFAALAGMVLSRLRTVLDGLAASLNGNPALLARLLAFIVGLLVLVGHGGLRHRLRRVLAASWTKLKATAGMGTKISYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPJ5</accession>
    <name>A0A367LPJ5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPJ5"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="142" mass="16040" checksum="1088BE68535BB3F3" modified="2018-11-07" version="1">MKAGARRRRKLLRRSNQLDEVLQGSKEDIAPEPKTQSVTVGDGVFTLSFLGLKAERGVVAGVGGERRKGNGWEKKCVVGRLGWNEEDEEEEDEEEEEEEEEEEEEGEEGEEEEEESNSNQQPATCICTHLILHNHNVAFRCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPM9</accession>
    <name>A0A367LPM9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Leucine-rich repeat-containing protein 40</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_2607</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPM9"/>
    <dbReference type="STRING" id="1330021.A0A367LPM9"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF27">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="321"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="716"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="83"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="142"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="295"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="762"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI16386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1021" mass="110076" checksum="2676CC5EEDFC5591" modified="2018-11-07" version="1">MEPVNIQSCNGLLRLPSSRFPPSNKARAAIGWTQNDGAFSDMDGPRDRPVPRISRLPVARPKPAVPNDASPCELQPRKLRHASSLSSCATPTATGSRPSLSQRTIDTLSQLPSSPAMTKKPSSFYDQRRPPSGTETTRPRSSHNSDSSARGSSRPGSRLGSDDCSLRPPAEGLKGSLATASTPRRRSHFGHTTPRSAVPPRRASVASPSRLPSAAAKKALETSPPAKTVAKTQAVRPAAPKLKADGLFRKPSLPAVGPIAGKPNHPRRPPPRDSQAQVAARNGAISPTRFAPQKSGEASSLRGARSSAALREHIAKAKAASRVAAKHANDAAPSVTSRGAFDPDASYDDPFNLQKGQDANAEVLKQRLSAARCSGRLNISALCLKEIPAQVVHMYDLENMGALDGSWAESVDLRRLVAADNEISTLDDDLLPDVDPAVLAEEADSPGGIFWGLETLDLHGNILSSVPLGFRRLLHLTTLNLSSNQLGNDCLDIIAQIPGLKDLSLAKNRLSGPLDPVLCRIGSLEALDLHGNSISALPVDMEDLLHLRTLNVNENHLASLSFDGLAKLPLTQLLVRKNKLSGTLIREPVHSLPLLQTLDASANQLTHLVPTGAVVGLPVMNAVSLSMNRLEELPDMTTWTNLVTLAVDENNISTVPDSFTGLGRLRHADFSNNHIRFVPPEIARMVELTTIWLRGNPLVDRKFATMSTDQLKDTLAARLEPPPPYQEAGEGQPRTERPAEKPTGAPETGDWDSRSDADDDFATPPTSAPHSPTRTPSATSSSPSRTAEAWPVKSGGLLDRAHTGLTDLDEAACLEVANRHRVREAQLHHNQLALIPVAVRAFGVTLVSLSLAHNQLTGSSYLTKELELASLTEINLASNAMTDLEPLTRFLRAPALDKMDVSRNRVKALPGNLKSAFPQLTVLLASNNQLAELEPEWIRGLKVVDVSSNEIAQLKPRIGLLGGRGGLQKLELSGNRFRVPRWTTLERGTEATLRWLRGRMPAEEMALWREENGVDSDEELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPQ1</accession>
    <name>A0A367LPQ1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Defective in cullin neddylation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_2459</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPQ1"/>
    <dbReference type="STRING" id="1330021.A0A367LPQ1"/>
    <dbReference type="OrthoDB" id="27198at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032182">
        <property type="term" value="F:ubiquitin-like protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.200">
        <property type="entry name" value="Cullin, PONY binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014764">
        <property type="entry name" value="DCN-prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042460">
        <property type="entry name" value="DCN1-like_PONY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005176">
        <property type="entry name" value="PONY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281:SF31">
        <property type="entry name" value="DCN1-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281">
        <property type="entry name" value="RP42 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03556">
        <property type="entry name" value="Cullin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51229">
        <property type="entry name" value="DCUN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DCUN1" evidence="2">
        <location>
            <begin position="56"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU410713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI16371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="274" mass="30896" checksum="0E6FFBD2BC685DDC" modified="2018-11-07" version="1">MAPASSAQQKSLIAQFVALTGASDRQASRYLRLAGNKINDAVDSRVPLPPPILNNLPPCQLQPLTNQVTDEENDEADKLEVNSTMDYLGSKLKVNLENAELLVILELLQAPSVGEISRRGFVDGWKAAGVGAAYQEHAAHVRRLISSLSSDLALFKRVYRYTFVVGRDQDQKSLSVENALIYWGMLFAPPGRAWKTKMHDWFELWKRFLEEKWTRSVNKDMWNMTLEFALKSTADESLSFWNEDGAWPTVIDDFVMWSRDKVAGKSESVVVVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQ32</accession>
    <name>A0A367LQ32_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQ32"/>
    <dbReference type="STRING" id="1330021.A0A367LQ32"/>
    <dbReference type="OrthoDB" id="5413829at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2790">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="323" mass="35259" checksum="FE27CE006140A3C0" modified="2018-11-07" version="1">MSSEVRKDDDAVQPKSSHTSDEFLRPFLKPTFDPASFLNGRLEKGTPLAQLSTQSQALVSQLDGQTTRMTDTLTQLTDDILRSGSRLAYEVELLRGETVGLSETLHETLQDDVRQFVPGGLRREAGGQETMEGGDSGGEAEDPDCIKQLQALTLVRAQLESVIKIFGAAMDFGFPPSEVSVGSSFLSVSAPEPGSEQQSSEEKGQQALRRLRDEVSELLGSNSKNGDDDDDDGDDDEDSAVQGIEKAATRVAELKELARVWRGTAEEKGRNRFIDSLAKMVEDRHRELMLESGRRDGKAEAEARVQPGGFGLMSQLQKLRSGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQ91</accession>
    <name>A0A367LQ91_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_2641</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQ91"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI16530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="89" mass="9948" checksum="7490E8EF87DA8B95" modified="2018-11-07" version="1">MSESGHAHLVYSPSPKRKIRTAVIYFLPLPLAFLLKHVDNLGMRAKFSLTLRLDLMASLQNAPGFVTQPRASTREYLSKRHAASLLQAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQN3</accession>
    <name>A0A367LQN3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">diacylglycerol cholinephosphotransferase</fullName>
            <ecNumber evidence="9">2.7.8.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_2943</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>CDP-N,N-dimethylethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33775"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
            <dbReference type="ChEBI" id="CHEBI:65117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:33776"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.2" evidence="9"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQN3"/>
    <dbReference type="STRING" id="1330021.A0A367LQN3"/>
    <dbReference type="OrthoDB" id="196717at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004142">
        <property type="term" value="F:diacylglycerol cholinephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000012">
        <property type="entry name" value="sn-1,2-diacylglycerol cholinephosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414:SF37">
        <property type="entry name" value="BB IN A BOXCAR, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015665">
        <property type="entry name" value="CHOPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="321"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="360"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI16765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="413" mass="45885" checksum="D01BACC987E0F2B2" modified="2018-11-07" version="1">MVYVRQRHLPALKEYKYSAVDRSLVSKYVLKPFYTHVVIKCFPMRMAPNLITLTGFMFVVANVLTLLWYSPALDQDCPSWVYYSWAVGLFLYQTFDAVDGTQARRTKQSGPLGELFDHGVDALNTSLEVLLFAASQNLGQSWRTVATLFASLLTFYVQTWDEYHTKTLTLGIISGPVEGVLTLASVFALTGYFGGGHIWQASALQTLGVPESIGIPALIYDLSFTDLFMVQGGCVLVSNTIESSFNVIRARRARGDRSRGALLGLVPFFAVWVFIVAYLLLQPNILENHLVPFVFFAGTVNAYSVGQIITAHLVKMRFPYWNVLGLPLAFGVLDSLGPFLQRHIGVGWPSALGDGVYQVAYLFLMLGAAIGVYGSFVVDVIVTICDYLDIWCLTIKHHHVDVPSPSAKKVKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQR9</accession>
    <name>A0A367LQR9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosomal protein eL8/eL30/eS12/Gadd45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_2003</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQR9"/>
    <dbReference type="STRING" id="1330021.A0A367LQR9"/>
    <dbReference type="OrthoDB" id="5364946at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004037">
        <property type="entry name" value="Ribosomal_eL8-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01082">
        <property type="entry name" value="RIBOSOMAL_L7AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="3">
        <location>
            <begin position="99"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI16690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="246" mass="26932" checksum="6A8DD66D5C19D334" modified="2018-11-07" version="1">MAAEKPDKIKEKKDKKKKRSEEAGVSKASKANRKEKKEKKEKLAAAVQDQLQREDGVAEKKPAVADDSDAEQPTTTSQPLQRTVVPFAIPISDEKGMKKTYKTIRKAAKNGTLKRGVKEVIKALRKSPPSAPGYTGFPGVVVIAGDISPPDVIAHIPVLCEDHNVPFIFVTSRAELGASARTKRPTSVVMLMEKRDAGKKKEVKDKEADAVAEEAEAYAEAYAALVKYMHKEYAKQAFWAKGDSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRD4</accession>
    <name>A0A367LRD4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphatidylinositol-specific phospholipase C X domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_2182</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRD4"/>
    <dbReference type="STRING" id="1330021.A0A367LRD4"/>
    <dbReference type="OrthoDB" id="7984201at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF80">
        <property type="entry name" value="PLC-LIKE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26146">
        <property type="entry name" value="PI-PLC_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI16910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="503" mass="53475" checksum="D9844AD717F25991" modified="2018-11-07" version="1">MRARSSSRRWRRRAVATRGRDRLASVRPLAAAGMTIITHSPLFKPWHIVSHPPPFSLSIFHFRPPLLTLTLSSYFPSLPSLRLSYKLKGGGEEGGGTLALLPLTPSPSLNHLHSPSHRCIMPSLRAVVATLASLAVTAAAAAPATAGSDAAAAACNNSPALCSRAYNKMTHLGAHDSSFLRDKSTNNSPAGNQFRNATLALDAGLRLLQTQLHKVESAQNDVERLRLCHSSCGILDAGPLDTWLRAVADWMGRNPNDVVTLLIVNADNVSPREIGAAFQRTGLDRIAYKSPPTAPAPTWPTLQTMISQGTRLVVFVTNTATAPDAPYLIPEFDHVFETGFEITQLDGFNSTLDRPRRLGDGQSAVKAGFMGLVNHFKYQTIGTGLLKSLAKSVGISANIMVPDADNAKTVNSPSLSAPGSLGRHLDECRTRWGQAPTFVLVDFWDVAGPLEAVDSLNGLGYGSVSGRTVVVPGPVTASAGREGACGMFVAVFLAVSASALVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRL8</accession>
    <name>A0A367LRL8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_1808</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRL8"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI17094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="44" mass="5024" checksum="D451DD747674B2B0" modified="2018-11-07" version="1" fragment="single">MYPGTNELTYIDISQTRSVLSYDVNGFASQGNRKACMQRIDHIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LS67</accession>
    <name>A0A367LS67_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LS67"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI17294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="94" mass="10966" checksum="889D15696B9301F8" modified="2018-11-07" version="1">MGDMAIDDHQPAYQQQQNHKHQACKARRRWFATARVEGLHEASADDADSVTLNTHLSEERARRSDLVFSNLTIRARHFSEYYIKLTIRTDLTRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KYZ2</accession>
    <name>A0A367KYZ2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPI anchored protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_1370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000031">
        <property type="protein sequence ID" value="RCI07388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KYZ2"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016802129" description="GPI anchored protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI07388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="93" mass="9223" checksum="9F644DB50A6DC201" modified="2018-11-07" version="1">MKVTQALVTLALIGGSIAQQSSSTHSMTSGRIVVATTTQRKSTETATGNARTSDSSETSSHRSSSSTGAAAVPTAGAMNMAPLLGMAVAVLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZ86</accession>
    <name>A0A367KZ86_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_4536</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000028">
        <property type="protein sequence ID" value="RCI07493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZ86"/>
    <dbReference type="STRING" id="1330021.A0A367KZ86"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI07493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="144" mass="16735" checksum="B77246A09C24EDDA" modified="2018-11-07" version="1" fragment="single">YSNSAKTRYKDIRTFSRKKGEFSAFLTNLKDKIRTDKATFRDEEDRIGFLFRSLEGKARKTLETRYNSIERPFSRLAEIIYLLTKTKDDSLSYEDFCGYIKDSAIKRLDAELVLPNDLPALAKYSLLILLPKTPLLNRQIDLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZG7</accession>
    <name>A0A367KZG7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PPM-type phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_1627</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000026">
        <property type="protein sequence ID" value="RCI07569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZG7"/>
    <dbReference type="STRING" id="1330021.A0A367KZG7"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000078">
        <property type="entry name" value="Protein phosphatase 2C, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF837">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C-LIKE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="7">
        <location>
            <begin position="141"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="275"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="518"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="521"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI07569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="585" mass="61611" checksum="CDA10A4F04A02DF7" modified="2018-11-07" version="1">MFGGGSNSSGIKTESEPKAEGRSPSPEPKSSPTTLTSVRSTDQAASGEKRSGNGSPTGRSDNGAAADKKRRGSGVGGKASSLLASARNSLSFSQGGRGSADPATQTPLQKLGKQDPALAVPQGQQNNSAGESLPGPKSTFRVGVWEDRNKKCRRTMEDTHAFLYNFLDTPSPAVDASEIDGADGEVEEAPHREMIQSDNGYFAIFDGHAGTFAADWCGKKLHIILEDNIRKYPNAAIPELLDRTFTTVDAHLEKLPLKNSGCTAAIAVLRWEDRAPSDRSGTGSMPMAPSAKGVTTSSDAKSSEQDAEAPAASVPEGVQSKLRASASRQRVLYTANVGDARIILCRGGKALRLSYDHKGSDENEGKRISNAGGLILNNRVNGVLAVTRALGDAYLKALVTGHPYTTETVIQTDIDEFIIIACDGLWDVCSDQEAVDLIRNVQDPTAASKLLVDHALSRFSTDNLSCMIVRFDKEAGPQNVDAKNLSGELDGPAVKVGEVEKIVMGTKQKIADGSLPAVGVSASNSSQRGNETAAASDGEFVPTTLDDMLEEEPAASTEDERPAKTADIGKASEDKTECEGDETGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZK3</accession>
    <name>A0A367KZK3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1646</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000026">
        <property type="protein sequence ID" value="RCI07596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZK3"/>
    <dbReference type="STRING" id="1330021.A0A367KZK3"/>
    <dbReference type="OrthoDB" id="4776522at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI07596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="445" mass="49368" checksum="6CEDDC39DB0F5547" modified="2018-11-07" version="1">MPPRTIMPGPERRCVFEPQCTHMTMTRIYDPSLLCLNCRCPGPSGWLYHCTQDREDLIEHAFSRGEVASFDVLGERMLEQLKIRKGSPAAREDKLSLLDEMTPNQMAAYRPDQIAIMLRQRENVQTACQFQRLRTDNSAEITSHRNYSTAFEGAPGPFEYKKPWVATFPEECRYRVCPRCRPALADRAFLSLNAVANGDIPPTAAVGYGFHTMGERPVFDAEMVQTLGIGVFLKAGEPGPQRRPKTPQSERQLPPMPKVCGSRNYFRSSESIRQLFGKPFAVPQPAEERSGAAGRPQDQGSTPGFIKHSPRCENLGKLAEQDKGIDLPTRSRPLRPPPGLPIPSGAEWNNGWGHRESTSDHDTESTIENTEIYPLPETVPLSSKSTGHGEADPRVHHADSHSPSPRDDSPDTSAKFASSPLKVKNGVAVLEESVELGVPDVVRHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZR0</accession>
    <name>A0A367KZR0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000025">
        <property type="protein sequence ID" value="RCI07656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZR0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI07656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="93" mass="9554" checksum="D66FE9283A607773" modified="2018-11-07" version="1">MSASYKPSIALAVSEGNSFGIIEQGPDPGPSTRPEGLGGSRDVGPAVAGPRPPYVTEAERHNNVGGGYAVQRLRPYGPYGPYEGRNVGLGTGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0D7</accession>
    <name>A0A367L0D7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">Autophagy-related protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_5895</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in cytoplasm to vacuole transport (Cvt), pexophagy, mitophagy and nucleophagy. Recruits mitochondria for their selective degradation via autophagy (mitophagy) during starvation. Works as scaffold proteins that recruit ATG proteins to the pre-autophagosome (PAS), the site of vesicle/autophagosome formation. Required for the Cvt vesicles completion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Preautophagosomal structure membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Vacuole membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
        </subcellularLocation>
        <text evidence="7">During pexophagy, accumulates in the vacuolar membrane region, where the peroxisomes contact the vacuole.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the ATG11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000023">
        <property type="protein sequence ID" value="RCI07871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367L0D7"/>
    <dbReference type="OrthoDB" id="447953at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903599">
        <property type="term" value="P:positive regulation of autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034517">
        <property type="term" value="P:ribophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040040">
        <property type="entry name" value="ATG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019460">
        <property type="entry name" value="Atg11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045326">
        <property type="entry name" value="ATG17-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13222">
        <property type="entry name" value="RB1-INDUCIBLE COILED-COIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13222:SF1">
        <property type="entry name" value="RB1-INDUCIBLE COILED-COIL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10377">
        <property type="entry name" value="ATG11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04108">
        <property type="entry name" value="ATG17_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="6 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="Autophagy protein ATG17-like" evidence="10">
        <location>
            <begin position="111"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Autophagy-related protein 11 C-terminal" evidence="11">
        <location>
            <begin position="1087"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="577"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1015"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1252"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="549"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="848"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="579"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="607"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1287"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1332"/>
            <end position="1351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI07871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1351" mass="151862" checksum="C99B9C8B39523A54" modified="2018-11-07" version="1">MATQVLIAHKGQRLDFDAAQFSSLDDLKAWIARTSSVPLQYMVALTPQGRSLKFSSLHSEREIYVYDIRVTQPSSTRSGSPSLVFETPSPRRLSIPAAPNSIDDVQAIASWQHLYEERRNWAVGLAEECSRMSSAAVARYDEMDVMIKCMDAALANLEISIKQIEPKYAELKKWVDPALLEHQKLATEWEQYLALARSVPVSSTMVEFMTRGEAAKPNTTLEDLVELETARKAGKLAPTARRRFGDKAAELDNLATQMYQAFEGLVADFDRLMNRSVLRHSTDSTKLLQDIEAIVGQIDADYRTSLEYGDSQRDLAQASKTASNHTERLVPSLKRRAKEMEEMVQYATRARNALVYDSAGHMRVITDITAQHSNVKNQINLLNHSEDDMTTFDYLRLIQQLPYMYASFVVEAIRRREWVDKIKVDSSTLANEMALFQDEETKRRKKWQKMVGSMYGPSVESAVVGLEVNLLGEDGPWPAMSKEELDGFLQILDAQGTDPTVLDDVGKLIQELNSPTKQQSKRLKAFKNGSVHEAALGRSGLLIRGDDVIRILQDDKSKLESKLKTADSRVRRLEDLLHRQSQASRQDSLFHSQPHERSDATSSIRTQRAEDRQRTSDGVEPLVCRIEQLEKELGEEKERSAGLEKDLAARAAQHDDMKDQIQEVNSTKKDLLENMEALKREFLDERKSLEDEIKTLKVRLEEAEDEMEHFGESREHEQAAYDEKVQALEAQMERQAKEWKDECLKFQGQVEFLRRENQMQRSQVDASEQQAQTVASENRALLKRLEAAQRTLDSQCLALEKLFGELAPGASPPAELMDLTESLQSHAGNLLAKLRNSESDSALIKADLGQALDSVKELKGEVAELKSKMSRDEAVANKLRDNLSEEQAKVAALDKEAIEVRAHLNELRGQLSDGETGSEALRKKLEGEERKAAGLTEELASRQSQLGSLEEEVHAYRAKTEGLSSRIAALTARYESRDSRTKDLTQRLYTQSDRLVRLLERTGYSVVREEGRMTINKIPRSERSSNDPSDPGPGLYRSTSLSMRAAADSADLELLYWMNSMDEKAEADKYDSFLDTLGSLDVDLFSETIYLRIKEAEHKARKWYREARSQRDRAHGFQKSARDKIAFKHFKEGDLALFLPTRNQQLGAWAAFNVGFPHYFLREQDAHRLRHREWLLARISRIQERVVDLTKSLQPTNDVESIKDEENDNPFQLSDGLRWYLIDAHEDKPGAPSTPGMGKSTLAANHVEATADIQSHAGKGKGKSRDSATSIEGINKTLSKSLDSRRSSSASKKAPPLPKNSALASETNSLRAAAPETPSGTSPVQGSFAGDEGARARTSGEVRKVESPPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0G7</accession>
    <name>A0A367L0G7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000023">
        <property type="protein sequence ID" value="RCI07933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0G7"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI07933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="114" mass="13167" checksum="A2A75BED630A64FD" modified="2018-11-07" version="1" fragment="single">GYKEAIKFFPEEKRLTSPERIYKKSFNKANKKTIAPNLPRLRKLHKGIPILIDRKAPRKRLSLRQLTFIVDLTLNFGRISLKSLIMLAFLDTSAETNILTASAARDLNLEYRPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0L2</accession>
    <name>A0A367L0L2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar protein sorting-associated protein 28</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">ESCRT-I complex subunit VPS28</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_7873</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Late endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the VPS28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000022">
        <property type="protein sequence ID" value="RCI07969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0L2"/>
    <dbReference type="STRING" id="1330021.A0A367L0L2"/>
    <dbReference type="OrthoDB" id="2671at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.200:FF:000003">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1130:FF:000001">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 28 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007143">
        <property type="entry name" value="Vps28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017899">
        <property type="entry name" value="VPS28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037206">
        <property type="entry name" value="VPS28_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017898">
        <property type="entry name" value="VPS28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038358">
        <property type="entry name" value="VPS28_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 28, ISOFORM 2 VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12937:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 28 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03997">
        <property type="entry name" value="VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017535">
        <property type="entry name" value="VPS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140427">
        <property type="entry name" value="VPS28 C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51310">
        <property type="entry name" value="VPS28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51313">
        <property type="entry name" value="VPS28_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0967">Endosome</keyword>
    <keyword evidence="4 5 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS28 N-terminal" evidence="9">
        <location>
            <begin position="18"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="VPS28 C-terminal" evidence="8">
        <location>
            <begin position="150"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI07969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="244" mass="27443" checksum="4AD0A20D59EC9415" modified="2018-11-07" version="1">MTRQGYAPTPHSYVPNTTLSATINLDEEVKLTETRAERDLQDSLAELFSIIITLDELEKAFLKDAIPEAEYTEICERSLRQYKALLADDTIAREFQGLEEFKAKWDTHELPSKMIEASRATERLRVGMPSTTVTASSSAAPPPASSANNTSGVLILEATQEFITFLDAVKLGMLSKDQLHPLLSDVIQSVNRVTDQDFDSRGKIVQWLITLNQMKATEELSEQQARELEMDIQQAYQGFRRTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L147</accession>
    <name>A0A367L147_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL18 C-terminal eukaryotes domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_6331</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L147"/>
    <dbReference type="STRING" id="1330021.A0A367L147"/>
    <dbReference type="OrthoDB" id="1618453at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00432">
        <property type="entry name" value="Ribosomal_L18_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.100:FF:000002">
        <property type="entry name" value="60S ribosomal protein L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_A">
        <property type="entry name" value="Ribosomal_uL18_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005485">
        <property type="entry name" value="Rbsml_uL18_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057268">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025607">
        <property type="entry name" value="Ribosomal_uL18_C_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410">
        <property type="entry name" value="RIBOSOMAL PROTEIN L5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14204">
        <property type="entry name" value="Ribosomal_L18_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17144">
        <property type="entry name" value="Ribosomal_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00058">
        <property type="entry name" value="RIBOSOMALL5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL18 C-terminal eukaryotes" evidence="7">
        <location>
            <begin position="246"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="260"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI08141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="309" mass="35523" checksum="D096C70C2628D60F" modified="2018-11-07" version="1">MLRTEMEQPLHKLVKNSAYYSRYQTKYKRRRQGKTDYYARKRLITQAKNKYNSPKHRLVVRFTNKDIIMQIVTSEINGDKILVSAYSHELKAYGIKHGLTNWAAAYATGLLIARRVLSKLGLDKHFAGVEEPDGEFTLTEAAETDDGERRPFKAFLDVGLARTSTGARIFGAMKGASDGGILIPHSEKRFPGYDMETKELDAETLRKYIFGGHVAEYMETLADDDEERYQGQFQKYIDDDVEADGLEDLYTEAHSAIREDPWKKAPSEEPKKSKEEWKAISKKYKTPKTPKAEKQKKVQERIQKILAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L268</accession>
    <name>A0A367L268_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8987</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L268"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="337" mass="35866" checksum="0DF2BF90D783206B" modified="2018-11-07" version="1">MLSFTTDCHIGKAFRRRHLSVSGRHANQSIRRSETANFGAPLPARAAGRQQPVLTDGHDRAVILRPHIHCEVTAGTLGRPTGEMPHCLCSDGSTKRCKVTSADAGFPGREKMTLDTRWPASSLKGMVANVVGLPGFIATRPKWMVPPRRRSMVHLAHGDAAGGDEHVGLSEASSERLLQRAGLVPCDAEVDDVEAPFLGGRDDRYAVRVADLAQSQRSGLDVLDNLVSGGQDADDGPSVDLDLGHADGREESDFAPDAGYLLALLRGARRQGGASSDSRDLAFPERLHLAGSRVRDGGDWEDSRHVSILGGDDGVTVDDTCPESGDVLPGLDGLGHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2F6</accession>
    <name>A0A367L2F6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial aspartate-glutamate transporter AGC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Aspartate-glutamate carrier 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L249_4885</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Calcium-dependent mitochondrial aspartate and glutamate carrier. Transport of glutamate in mitochondria is required for mitochondrial transamination reactions and ornithine synthesis. Plays also a role in malate-aspartate NADH shuttle, which is critical for growth on acetate and fatty acids.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer (via N-terminus).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2F6"/>
    <dbReference type="STRING" id="1330021.A0A367L2F6"/>
    <dbReference type="OrthoDB" id="2161at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015183">
        <property type="term" value="F:L-aspartate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043490">
        <property type="term" value="P:malate-aspartate shuttle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000004">
        <property type="entry name" value="Calcium-binding mitochondrial carrier protein Aralar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000552">
        <property type="entry name" value="Probable mitochondrial carrier protein ARALAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051028">
        <property type="entry name" value="Mito_Solute_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678:SF9">
        <property type="entry name" value="CALCIUM-BINDING MITOCHONDRIAL CARRIER PROTEIN ARALAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45678">
        <property type="entry name" value="MITOCHONDRIAL 2-OXODICARBOXYLATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="97"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="16">
        <location>
            <begin position="169"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="337"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="435"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="15">
        <location>
            <begin position="533"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00059916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00073787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00082232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCI08606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="698" mass="77345" checksum="B53DCBF131EBEEF6" modified="2018-11-07" version="1">MSKATAVKETLLGSGEEAPQLSAKSRARFTACAVKDAETGELYMGPDEFINAVAPKDEDYHKIKREQYSILFRIADSRGIGRVSMADWSVFENLLMKPDAEYEIAFRLFDVDRTGSVKYEDVRRLYELNKGPDNLPFDWDCEWARLHMGSKKKRHDLSYAQFSQMLRGLQGERIRQAFQLLDTDGDGYINPDEFERIIRETSRHKLSDHLLENLHTLCNISTGTKISYANVRAFQNVIRDVDLVEHIIRRAAARSADGKITRADFVREAARATRFSLFTPMEADVLFHFASLDEPSGRLGLGDFAKVLDPTWRGRAYDGGDESDRAYGSSAVLRKAAESTYNFALGSLAGAFGAFMVYPIDLVKTRLQNQRGALPGQRLYKNSIDCFQKVMRNEGIRGLYSGVLPQLVGVAPEKAIKLTVNDLVRGYLTDGEGKIQWWSEVAAGASAGGCQVIFTNPLEIVKIRLQVQGEVAKTVDAAPKRSAMWIVRNLGLVGLYKGASACLLRDVPFSAIYFPTYSHLKRDLFGESTTKKLGVLQLLTAGAMAGMPAAYLTTPCDVIKTRLQVEARKGEASYTGLRHAAKTIWREEGFRAFFRGGPARIFRSSPQFGFTLAAYEVLQGLLPMPGSTGGAKAEAKQMTTATTKMTTPTTTEMTPWGRSRNALKMILDMDEDFGIGKMPDQKGWRSLPRLMGGGGGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2G0</accession>
    <name>A0A367L2G0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_4886</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2G0"/>
    <dbReference type="STRING" id="1330021.A0A367L2G0"/>
    <dbReference type="OrthoDB" id="5368516at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="502"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI08605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="572" mass="61497" checksum="43AFD06A1EA653A5" modified="2018-11-07" version="1">MDGAGLWAGANDDGLDDVVSRLSSTADVDDETRLAMEKSLRTAFTVLAVINALVGATTALGIYLDCRFQTKRKPEPMVRRFVVGAKEMLPFAVSLGIVAQGALFAAAQTKGLDAVLTLGCRSVSQLMLPALFIVPFIQTVFGFEAMARSLPRQPVRHGAAWTVSLCVGLVLVGLLISYVVTQVTQPANFCFAEMLFLVREWSVGVLAVLIALIGLLLLGSVLLLARLYRTEGMAPTQRTTASWTACYMLLAVVTMLMTVPFFASLVSDASASSDVTREMMQLSTAATIVVNLTGLLTGALYLVLRLTRLGRLGCSGYVELDRQRLKSGIRTVRASSVMYNKQLEQPLSPGWLERRAGGGSFYSWSDEKKKQPVAVSVSETRKAGGGAAPSYSIFPHPHPHLDPHPHPHAAPQIEADDFLVPPSAPWANRRERNSSLGSSATVPIALRVSNIDNIPVQQMSGSSAAAPLYQATVQQQQRRLISPGKLGLAISTNDAYRLSKTVDVFDDDDDDEDEDDDDGARGGPLPPPLAFTKADEAKPDDDGFTLSPTVYSPDSSPSVRTPPPSAQPKAWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2G2</accession>
    <name>A0A367L2G2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">holo-[acyl-carrier-protein] synthase</fullName>
            <ecNumber evidence="1">2.7.8.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_4712</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.7" evidence="1"/>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2G2"/>
    <dbReference type="STRING" id="1330021.A0A367L2G2"/>
    <dbReference type="OrthoDB" id="26719at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055066">
        <property type="entry name" value="AASDHPPT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050559">
        <property type="entry name" value="P-Pant_transferase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12215:SF10">
        <property type="entry name" value="L-AMINOADIPATE-SEMIALDEHYDE DEHYDROGENASE-PHOSPHOPANTETHEINYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12215">
        <property type="entry name" value="PHOSPHOPANTETHEINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22624">
        <property type="entry name" value="AASDHPPT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="4'-phosphopantetheinyl transferase N-terminal" evidence="5">
        <location>
            <begin position="70"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="4'-phosphopantetheinyl transferase" evidence="4">
        <location>
            <begin position="203"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="293"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI08623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="393" mass="44718" checksum="793BA68179E29285" modified="2018-11-07" version="1" fragment="single">KEKESESEREEKEKKGSLGPRRTLPPFGRARAGPNGAMETPVSIIQWALDTRPLWPSATETRDLKQAASREFNLLNDKETEQIQRFHFVKDAKLALASALLKRLAISRLANVSWTEASSWKRDVRTGKPIFDMPRSSSPSSSVKKNKKKKREGIKFNVSHQAGVVVLVASSLVAQDDDDDDDDDDQVGEEEEEEEEDEKKLDVGIDVVCQGERREKDLTSIAAEGWSRYVAVHEDVFSPHEAAALRSREGDDDDSRLAYFYTLWCLREAYIKMTGDALLAPWLKDLEMRHFAPPPPSSSLSDQHHHHHHHHHQQNSTSHDPRLEIWFRGRRVEDVCMRLSSLLEDEYVVCTAVRCPPRLRACVESQLALPFTHLVLDDMVTEAEEADRRGQLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2T6</accession>
    <name>A0A367L2T6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_4760</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2T6"/>
    <dbReference type="STRING" id="1330021.A0A367L2T6"/>
    <dbReference type="OrthoDB" id="2272012at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04435">
        <property type="entry name" value="DEP_fRom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041675">
        <property type="entry name" value="PH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052233">
        <property type="entry name" value="Rho-type_GEFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF2">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15405">
        <property type="entry name" value="PH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="4">
        <location>
            <begin position="543"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="5">
        <location>
            <begin position="917"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="223"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="290"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI08717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1252" mass="141653" checksum="746FDC3C6D4DD9D2" modified="2018-11-07" version="1">MADYHYDPRSAPQRPRGYPDPSNHQRDAAFSNIFGAAPPPGRSQTMTASSSHPAMMEPGRTQTMSMASGQPRQPPGRPQQPYFYGDHNRNGPYAGHYAGQRSASGGQTSPASQQPQFMQQQPPPPPPPPPPPPPQQQQQQARRPYPSGPSPPRSESRGPTPQAAAMRYQPQRSYQGAPGPALNSDPYRSQSLASMPRPQMYHPPPSSYQQQHSPASHSRFAQYGQQNSARTTAQGRVVPERHEDRTMSMTSSFHHPQDRDAHQTMSGRVIPNRRAPSDATANGYPLQGGAYSNTPGTQTRAPAMSSPTDHSRSMSMASSIAPTIVASDSDPPTPTQRPSRSKSIESERPPTATKIRPPLVYPALLSRVAECFRRKIILGDRTKNELTYKNAFSGSEAVDVLSYIIRTTDRNLALLLGRALDAQKFFHDVTYEHRLRDSMSEMYQLRETMMDEPEEKSPVNGIFVLLSECYSPTCTRDQLCYSIACPRRLEQVSRLNLKTGPGLRKEDSANVNDDEADQTDEQKLWINSVPKEIADAVDEREKKRQEVISEICYTERDFVKDLEYLRDFWINPLRSKASPIPLQRREKAVKNIFSNIVDHPSIHSVSSRFASSLTARQGKEPIVYNIGDVFLEYVPQFEPFITYGSRQLEGKFEFENERSINPFFGKFVDEIERRKESRKLELNGYLTKPTTRLARYPLLLENVLKYTEGDNPDKTDIPKVLTMIRDLLGRVNAESGKAENRFNLRRLHDQLRFRPNERVDLKLTEEGRELVFKSQLRKSPTDPSEITAFLFDHAVLLVRVKQSGKNEEMKAYRRPIPLELLSIREMEEVIPTQGVKRSSSSLIPSIRTNNSEAKKGEGWPITFRHLGKAGYELALFAANQAARKKWLEFIDNAQQRLRSRADFFNTTTVSSNFFVGTNQIRCVTPFDGGRKLLYGTDNGIYLSDRKNREQVPRRVLETTNVTQIDILEEYQLLLVLSNKTLHSYSVSVLNPEEAAAAKRPKKIQNHCSFFRTGICMGRHLVCCVKSSALSTTIKVFEPNDAMTKAKKQKGLGKFMAGQDELRPFKEFYIPTESSSVHFLKSKLCVACARGFEVVSLETLETQALLDQADTSLDFVARKEGVKPIHIERLNGEFLLNYSEFSFFVNRNGWRARPEWRIDWEGTPLSFALSYPWILAFEANFIELRNIENGAVHIVPHKNIRMLHSSTHEILFAYEDERGEDVVEAIDFWKNTRRSEAPASGTVAGSGPSSSMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2U6</accession>
    <name>A0A367L2U6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Auxin efflux carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_4686</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2U6"/>
    <dbReference type="STRING" id="1330021.A0A367L2U6"/>
    <dbReference type="OrthoDB" id="2499604at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_transp_PIN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31794">
        <property type="entry name" value="AUXIN EFFLUX TRANSPORTER FAMILY PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31794:SF2">
        <property type="entry name" value="AUXIN EFFLUX TRANSPORTER FAMILY PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="470"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="506"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="545"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="220"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="220"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI08727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="570" mass="62526" checksum="935C7AB961396F69" modified="2018-11-07" version="1">MDPATSFVRPVSYRLAHVARNAYDYPMAVLQGEPSGHPSLPHLCLLVFEAVLEVVCVSLPGYIIARLGHFDADKQKFLANLNVMLFTPCLIFTKLASQLNAEKLTELAIIPAIFFIQTLISWIVSTLMARAFQFNKRASNFVTAMGVFGNSNSLPISLVLSLSQTIKGLHWDRITGDNDDEVAARGILYLLIFQQLGQLVRWSWGYHVLLAPKDKYPEYQQQAAEEGQGRYGEAQGEHETQRLIDDLDGGETEDDDERHSVDSRTYVPDGQTPLAGTSRASADSSDDDFAPKKPQHARGTSRPPVAPPRAPHTLAFPRVDSSGDESAPITEPNGVLARLKASAARGLRSFQARASRCLCDLAERLPDPIRLPLSMLVTASRKAALFIWEFMNPPLWAMLIAITVASIPALQKLFFEEESFINNSVTSAVKSSGGVAVPLILVVLGANLARNTMARDDNHDPEEEQVGNKLLVAALLSRMVLPTLAMAPILALMAKYLPVSILDDPIFIVVCFLLTGAPSALQLAQICQINAVYEKTMGRVLFQSYVIWILPSTLVLVMMALEVVQWAAVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2V9</accession>
    <name>A0A367L2V9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DSC E3 ubiquitin ligase complex subunit A</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Defective for SREBP cleavage protein A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">RING-type E3 ubiquitin transferase dscA</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">L249_4813</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalytic component of the DSC E3 ubiquitin ligase complex which is required for the srbA transcriptional activator proteolytic cleavage to release the soluble transcription factor from the membrane in low oxygen or sterol conditions. Required for growth during hypoxia and triazole drug susceptibility, as well as for virulence in a murine model of invasive pulmonary aspergillosis (IPA).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the DSC E3 ubiquitin ligase complex composed of dscA, dscB, dscC and dscD.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2V9"/>
    <dbReference type="STRING" id="1330021.A0A367L2V9"/>
    <dbReference type="OrthoDB" id="9984778at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044695">
        <property type="term" value="C:Dsc E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000626">
        <property type="entry name" value="Transmembrane ubiquitin ligase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021319">
        <property type="entry name" value="DUF2921"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024766">
        <property type="entry name" value="Znf_RING_H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763:SF162">
        <property type="entry name" value="TRANSMEMBRANE E3 UBIQUITIN-PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11145">
        <property type="entry name" value="DUF2921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12678">
        <property type="entry name" value="zf-rbx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 22" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016975940" description="DSC E3 ubiquitin ligase complex subunit A" evidence="22">
        <location>
            <begin position="28"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="399"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="429"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="558"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="585"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="616"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="23">
        <location>
            <begin position="729"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="494"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="503"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00056116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00063126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00071072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00077885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00082128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="RCI08771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="794" mass="88131" checksum="BA5A6C7726D50156" modified="2018-11-07" version="1">MAFYRHPVVGLILVLLLLWSFFPESENRSTTLSEIATSHLSRYRDALDTLSASAWGDFSPDAAPANTTSRFLNLTGFREVDGFAWDDLTKFRERVLRLSRHAISPVAGRQLWDVAQGDPVWANPSGTLRGEWVRRSGSVSRRYDSYNLSLSVPAMDWVGDRVEWARNITGAQGRMTLRLEANRTVIRYDDMAPDTRPLSGGSIRDIKGAVIIEDLDGSGQSWDMRLYGVHWPRQGVILMTTTSEKFEGIFGLPHLAPSPDFFLSSQMMLNDTLERVISRKQRNIKVDPNIPWNSNVGSPLYTAYPSPNCELVMYAQVLPPLERAMDGAASSEERLRAIESEVENPIGAAVGPIPPLELSVIVYSPDCAFFLETNGPPDFLPSKRSHLVGLKAASHTTRVKRWISAFALVIFAQVYLFKQQIQETFTPSTIARISFWTISAMTIVDGIAFIAALTWIPSSRATYQPTALFAFAAFLSTLTAGCLLAKIHEAQLPESRSRRDANPGDGRAAPADAGFAPEPIIVPSDQDVDAEITAAASAVPRAATGGSLPSPQQTFQSVVGRLFIFSLCIIFVAVSSSTWPPGSRSVFLSLCAFVYLSLWVPQIYRNTMRNCRHSMSWRFVIGQTVLRLLPVAYFWIHEDNFLFARPDRTAFSVLFCWVSLQLAVLAVQEVMGPRFGVPDSWTPDGWDYHPVLHEEAIEGGRLPIGLAAGASWHGSDAASKSGNVRVVECAICHEPVDVPVVKAGGEEDGSVKSVFARRLYMMTPCRHIFHTRCLEVWMRYRLQCPICREDLPPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L321</accession>
    <name>A0A367L321_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_4825</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L321"/>
    <dbReference type="STRING" id="1330021.A0A367L321"/>
    <dbReference type="OrthoDB" id="4451586at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052761">
        <property type="entry name" value="Fungal_Detox/Toxin_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425">
        <property type="entry name" value="FARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425:SF2">
        <property type="entry name" value="FARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="27"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="328"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="626"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="789"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="847"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="328"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="631"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="700"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="791"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="848"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="859"/>
            <end position="868"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI08825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="881" mass="96434" checksum="83AA5978962384FB" modified="2018-11-07" version="1">MEKPAAKRPLETTTTPHKVTKRRAARACVSCRARKVRCDVVEGAPCGNCRWDNVEEESQCAIVTAATTTDDESLLIDQPHDLLHDLSRIKLLAQDDGLPPFILPLPDKMAVDDAAYLRAKGALTIPSASLQSALLRAYAEFVHPYMPLLDLDDFLVVVGAGRRRRRRRHHHHHHHGRVSLFLYQAVAFASTAFVDIRHLHQAGFATRKAARKAFFQRTRLLYDLDYEADRLVLVQGLMLMTYWYETPDDQKDTWHWMGVAVSLAHTIGLHRDPSRTTMTLKRQRLCKRVWWSCVMRDRLIALGMRRPTRIKDEDFDVPMLTEADFAVQEEEEAEAEAEAGAEAEAEAEEEEEEEEEAEEEGGEAGLGPEPGPGPELEPGVDPASSWASSCPAVADPAIRRELAQLCVAKARLCLCIGHMLKAQYSFMLRREPHKTTSCTMMLFPLSPQPDDVAAVDAELAEWLVSLPPACRDRPLVNPLDGRADNAAVAVQRTLLHMFYHTIVAALHRPQFLLAGGPMTRPLQDMARLKVRDAAGEITRMATQLHALHLDRFLPTTAVTVLLPAMMVHLLDMKSQGGTTRHKAVRAFRQCMRVIEKLRDMYTAADYATGFLDAALRKAAIDVNDKSMATPQQPPPSPPPPPSPPLPPLPMLLPPGCVHTPPPEKTTPYMTEAESFFAAQPDDDDGDHYHHHLPMPPEPTPTTAVTTSTEPWPTLLPPPETMQLAAAALDFGAGGSPPHTDMTTMTTPSASGGSDAVFFPPNVDFDPMMLGPDEFGADFDVDQWLQFPPDVIGGGGGGGGGGGGGGGEDDEAGGGSGGYDTEMMNNDDGLDGIVAAVDGADEVLVATLKDMKGDDHHDEGEDDNDDDDINLVSETFDGRQMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L336</accession>
    <name>A0A367L336_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_4637</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L336"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI08839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="95" mass="9739" checksum="C1FF8F3F94D5892C" modified="2018-11-07" version="1">MYYSPESPLSDWPFRAGGKNGRVHPVDDTFHPVALRALPSFPPLFIDRGGGALLITIAAALVPLASFKAAAAAASASKATAASSAAEEEETAEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L387</accession>
    <name>A0A367L387_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glucose-repressible protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4879</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L387"/>
    <dbReference type="OrthoDB" id="10039103at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020100">
        <property type="entry name" value="Glc-repressible_Grg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38789:SF1">
        <property type="entry name" value="GLUCOSE-REPRESSIBLE GENE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38789">
        <property type="entry name" value="REPRESSIBLE PROTEIN GRG1, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14210)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11034">
        <property type="entry name" value="Grg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="69" mass="7189" checksum="838F7AEF4D3F239B" modified="2018-11-07" version="1">MESLKQGANYVSETVQKATSGVSKEANKEVAKDSNAGVGTRVSAAKDALGDKAQETKHDAKAEAHKQST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3E7</accession>
    <name>A0A367L3E7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_5079</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI08949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3E7"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017000949" evidence="2">
        <location>
            <begin position="24"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI08949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="557" mass="58466" checksum="F3BD47AB512EF973" modified="2018-11-07" version="1">MKSLGRLLLYAKLLLVVTDHGAAIPAPTWPGWNQPVNPAALNAQMNAAANKMAQRNAAANAWVVKPVVWNWVPLIQLKPGGKHHGQKHHGQKDRNKNRIEKAGPKKKPGGDGAKNGNDGGGSKPKDTSGGSKPEDTSGGSKPKDTSNTGDDSSGDSTKAGEDGDGSNSFNMGDTKGKKGDVDGSPAPNDDTLGSGGGTSDEGDADPFPGTENDGTGSGETKRSGEGDGGGGFPGDDDDTGGGGTTSTGGEDGGFPDDNDDTGDGGTTSKGGDDGGFPDDNDTTGDGGTTSKGGDDGGFPDDNVDTGVEEPPGGDDGGFPGDNDTTGTEKGDDAGDFDNIDSTKPTAGGDFPDNNNIDDTETGSGDVPKREEDRMGLETRTLSVLRPSVQDQLLVLGEEETADRLEAETRTRWGSRPRLQPWVQDQLLVLGEEVEDRIHLEMRTLSLMDRLVLGPLVLDQLLELEEETAKDQEIEQLPLHPLVLDQLLELEEEAAKDQEIERLPLHPSVLDQLQVLKATDLLHRLRPPHRSQLPVAKMGSLSVVDLSNRQRPGRPSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3U3</accession>
    <name>A0A367L3U3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mediator of RNA polymerase II transcription subunit 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Mediator complex subunit 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_5048</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the Mediator complex subunit 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI09103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3U3"/>
    <dbReference type="STRING" id="1330021.A0A367L3U3"/>
    <dbReference type="OrthoDB" id="5310959at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019680">
        <property type="entry name" value="Mediator_Med1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35041">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35041:SF4">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10744">
        <property type="entry name" value="Med1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0010">Activator</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit Med1" evidence="9">
        <location>
            <begin position="121"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI09103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="662" mass="72007" checksum="2D3CB3D3B3A3331B" modified="2018-11-07" version="1">MATPTPMKHAPSQQGRTPSQQGRTPSQLAAAATPPVSTPFSNPAHTAFSPRGPKSSPQQVKKSPANHGTLGAFNFDSPSTAAAMGALGIGPGFDIGLDNVAGLEGLSALTGEDDKLKRLEAILNILAEKRGLVSEAGLERLAQRIGLELLSEEQTTPGGRKTSTLAIAGSAMALDIVLDNNIVQSVSLSYHGSATSVSRHMDAAGRVLLQDLQLPPGQSPLTKSLSSFASNLERLAVLDKLSIVPGLDCHEALAGIYDSLERLHQWDLAKLRQEPSMAARSDAELTTTAMCARHGIPVMHARRKVGLALQYWKTSRLAPPPPPDSSKTAGDKVWSLLIGCAPIEGLGLPPVRVSENWIAKEVTKSDGFVLDWLEPDNVSLPQSEENKDAAMDMLQPDLSTTRVPRVMFTVSFDPPVVLPQNDWSRLYMCAAVNPPDAELGPTFDSLLFPVRPGERLEPSEPRVLRRCRRHVRVFSRDGGKPLFRHHDNTLLIYKPIYSQAVTEMPFSHPRQLIDMLPLLRQYALVSILLETSFGGQTADDEADVPTTTKRTTTTTKTQLLSFTDKPSVPVATTRLKVTLWIHASPHLQVMFPMSDATTADVTIRVVEGGLVEIMEENVLDTAAAGKGKRKEVTRQHLARALESFEDLNKWCEWIRTRLGGPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L473</accession>
    <name>A0A367L473_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L473"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="121" mass="13499" checksum="D3DCBB1614EC5228" modified="2018-11-07" version="1">MQPRADGRHRAAPLPRKGISLSTNDGWETSGALNVVRPSTIFARARLEPRRHHLFSPRQYDWTGLTRQAHSLQGPFQAAHYRSWQEIGVLRPATPPFSAPTPILTGAGTGRRRRHETGTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L477</accession>
    <name>A0A367L477_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_1405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L477"/>
    <dbReference type="STRING" id="1330021.A0A367L477"/>
    <dbReference type="OrthoDB" id="3532430at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="192"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="233"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="468"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI09235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="586" mass="64524" checksum="4A124A124BE9BA48" modified="2018-11-07" version="1">MADADLPIALRKPRRSVNGVSSRPAPALCDPQTPRRTKRAVRFSDPGPRSLRTTGLTPMIKRTSIATPQRRRASTPSRTTTPSKTARADAVPAREVAPQCLRHTTDGRVERRIRRNNFRELLNRLEQQKKSRTRELARLKAEIKARDRDIYELRNATVIVDTERIWHLERQVTELKEELEVRSTTGHGIYDWVRDSLGDDDDDDDGDEATNPFSDDDQDDHFGDMAVLNLAASTPSRALRSRDPLTPPATSPTGPGTPCWRDGPDRVDAAVQASFTDPRVEEELASLRLEVKRLTTTLDSHRDLGERIGRRLQASAASVAGFGAIEQQIESLVRTLSDRTAALSKLTSDIAALGFPGHDAGDMVAALATGFRSARLELEYLTPGELTLPLTSRGPEILDELLSRLRQLAKGAAEDEATIDEYHATEQSLRKQLDSRVSAMDDLSADASRAQRLAEEQRVANHRLRHAIDGYVRDMSELEALIERMEREGGAALAARDASIAALENRLSDTLSRAHHLETEVSAAGDVGVAAALAMRDARILDLTAELDLGRQAVAGLEAGLDAERGRVRDAMRRVVDIGKGFLDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4Z2</accession>
    <name>A0A367L4Z2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Polynucleotide 5'-hydroxyl-kinase GRC3</fullName>
            <ecNumber evidence="26">7.2.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Polynucleotide 5'-hydroxyl-kinase grc3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="33" type="ORF">L249_3969</name>
    </gene>
    <organism evidence="33 34">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="33 34" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="33 34">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Polynucleotide 5'-kinase involved in rRNA processing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>K(+)(in) + ATP + H2O = K(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75815"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>Na(+)(in) + ATP + H2O = Na(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="28">
            <dbReference type="Rhea" id="RHEA:14634"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="25">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IID subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="33">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.3" evidence="26"/>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367L4Z2"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008554">
        <property type="term" value="F:P-type sodium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000193">
        <property type="entry name" value="Plasma membrane calcium-transporting ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000160">
        <property type="entry name" value="Sarcoplasmic/endoplasmic reticulum calcium ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1030">
        <property type="entry name" value="Clp1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.330">
        <property type="entry name" value="Pre-mRNA cleavage complex subunit Clp1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03035">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028606">
        <property type="entry name" value="Clp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010655">
        <property type="entry name" value="Clp1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038238">
        <property type="entry name" value="Clp1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032324">
        <property type="entry name" value="Clp1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038239">
        <property type="entry name" value="Clp1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006414">
        <property type="entry name" value="P-type_ATPase_IID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01523">
        <property type="entry name" value="ATPase-IID_K-Na"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06807">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16573">
        <property type="entry name" value="CLP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00121">
        <property type="entry name" value="NAKATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="21" id="KW-0406">Ion transport</keyword>
    <keyword evidence="16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="22 30" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-0630">Potassium</keyword>
    <keyword evidence="9" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="34" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="20" id="KW-0915">Sodium</keyword>
    <keyword evidence="23" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="18" id="KW-1278">Translocase</keyword>
    <keyword evidence="12 30" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="19 30" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="30">
        <location>
            <begin position="729"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="30">
        <location>
            <begin position="753"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="30">
        <location>
            <begin position="959"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="30">
        <location>
            <begin position="986"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="30">
        <location>
            <begin position="1467"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="30">
        <location>
            <begin position="1555"/>
            <end position="1575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="30">
        <location>
            <begin position="1587"/>
            <end position="1607"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="31">
        <location>
            <begin position="176"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="32">
        <location>
            <begin position="675"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="29">
        <location>
            <begin position="1613"/>
            <end position="1636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="29">
        <location>
            <begin position="1625"/>
            <end position="1636"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="33">
        <location>
            <position position="1636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00035017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00035029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00048599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00049499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="EMBL" id="RCI09489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1636" mass="176263" checksum="6934074779C4553A" modified="2018-11-07" version="1" fragment="single">MIVSSGKVRGFRWYRCWLDHVTGHDERRTKKKNHIHDDDDDDDESKLTNVLVMSIPGLGQIPAQTVASSTRNISLLKPGWEWRFEVAAGRSITLKVLSGRAEKDGVELAPRKCYTFSGVKSKILTWHGCELEVDGRCDDDFVAEYAAPADNPANAVLNLHAFLSSMRSMAAANGREGPRVLVAGPPNTGKTTMVRTLASYATKQGFQPVAVNADPREAMLSLPGTLSAAVLATVLDPEAVDGWGSTPTSGPSDVPAKLPLVYMYGRSSPEDDAELYRELVGRVGTAVSGRLNADADVRSSGVLVDTMRVSEKSKIGLDLIAHIVDELSINIVVVIGSTRMNAELTRRFAEEKTSLGEPIHVILLDRFEGVVDRDDAFLEHAREQVIKEYFFGGAGRALSPQIQQVDFDSLVVYKAPEYSILGQDSLIREEPSSVMEHWTLAVMHASAKDAPEVVRAASVVGFVYVSYVDEERRKMKLLAPVGGRLGDRPLIWGKWPEPYINFCVLLFKRWPRSTTSPPRRISVPDRLRGEETNARSSAGVINNELQFHSGQGIILPLSRCLPLMDEALCSEAYRRRASPPPFPYLPSPFLDPAVLSLLLIAPHRAEITNCILSPSLVSASAPSAAKSSLLYDSFSPKHPLDERTRHDQCDYRKSRQTAPLSAEGLPDVAIKKPQCAHTLPVELVAAQLETDARHGLSDDEAAARLLRDGPNTIGSAAAVSIGRLLFRQVANALTAVLVFVACLSAVIGDYIEAGVVAAVIVVNMVVGCDAPFATLIPRALTRARLAQDYGAEQTIHALYALSTPQCRVVRGRRSRKIQAVSLVVGDVVSLATGDVVPADLRLVKGTNVVMDEAPLTGESAAVAKAPHAVFADAEMPIADRTNLAFAGSAVSCGRAIGIVVATGMETEVGRIARMLRHRNKHDGNSGGGWVARALNSVRRCLSSILGLDGTPLQVALSKFALLLFGLAFLLICVVFSIHRWQLNTDVFIYGVCVGVAVIPESLLAVLTVTMAMASKAMAKGNVIVRRMPCLEALGGVTNICSDKTGTLTQGRMMVRVVWLREGLTGTVEGSTNPHDPSSGSVSWSAPLAGSCFEVFLSTIAACNQATVMDGKDGAETGTGKETCRWWAVGEPTEVALRVFAMRFGRAGSPVESPSAEYPFNSRRKLMSVVCDCASGRRRIHTKGAVESVVPLLDETDEAKAAVSDKAGELAAGGLRVLCIADRVMAAEDDGFDRAEVEQRLRFLGLVGLCDPPRPETAAAVQQCRRAGISVHMLTGDHIKTATSVAYDVGILTRERCGGGPAGRVMSASDFDSLCDEEIDGMESLPAVIARCSPLTKMRVIQALHRRGAFCVMTGDGVNDSPALKQADVGIAMGNRGSDVAKEASDMVLADDNFASIFLLHLLISNLAQDDRGACVFPLSPLEILWANLVMSSPVALGLGLERAQSDILERPPRKPGVFSLDLVRDQFAYGTLTGALSLAAFMLVVYAGSSPGSGGFRRLPHGCNDAKAGGPCDVIYRARGATFTTLSLLLLATALEVRSSHRGMLDCGSVWRNKVLFWAVLAGLATTVAVLYVPVVNVDVFRHQPLTWEWGVVLGCLATFVVGVEAWKAMKRKKTVGQARMKEKEKKKKKKKKKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L545</accession>
    <name>A0A367L545_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_3920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L545"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI09537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="71" mass="7767" checksum="00BED94762DE0584" modified="2018-11-07" version="1">MIQADRYKHANSRRRRWSSAGLEQRPGPTHRLSPGPACRGGTIIIVSCHAGVHAVCLLPLLLLLVIYLPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L572</accession>
    <name>A0A367L572_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Nuclear distribution protein PAC1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Lissencephaly-1 homolog</fullName>
            <shortName evidence="13">LIS-1</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">nudF homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="primary">PAC1</name>
        <name evidence="13" type="synonym">LIS1</name>
        <name evidence="16" type="ORF">L249_3908</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Self-associates. Interacts with NDL1 and dynein.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
            <location evidence="13">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
            <location evidence="13">Cytoskeleton</location>
            <location evidence="13">Spindle pole</location>
        </subcellularLocation>
        <text evidence="13">Localizes to the plus ends of microtubules at the hyphal tip and the mitotic spindle poles.</text>
    </comment>
    <comment type="domain">
        <text evidence="13">Dimerization mediated by the LisH domain may be required to activate dynein.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the WD repeat LIS1/nudF family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the WD repeat MDV1/CAF4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L572"/>
    <dbReference type="STRING" id="1330021.A0A367L572"/>
    <dbReference type="OrthoDB" id="10264588at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007154">
        <property type="term" value="P:cell communication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051012">
        <property type="term" value="P:microtubule sliding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0023052">
        <property type="term" value="P:signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000342">
        <property type="entry name" value="Nuclear distribution protein PAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.960.30:FF:000002">
        <property type="entry name" value="Platelet-activating factor acetylhydrolase ib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03141">
        <property type="entry name" value="lis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017252">
        <property type="entry name" value="Dynein_regulator_LIS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037190">
        <property type="entry name" value="LIS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056795">
        <property type="entry name" value="PAC1-like_LisH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF637">
        <property type="entry name" value="WD REPEAT DOMAIN 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24951">
        <property type="entry name" value="LisH_PAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037647">
        <property type="entry name" value="Dynein_regulator_Lis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109925">
        <property type="entry name" value="Lissencephaly-1 protein (Lis-1, PAF-AH alpha) N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 13" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 13" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 13" id="KW-0498">Mitosis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 13" id="KW-0813">Transport</keyword>
    <keyword evidence="3 14" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="PAC1-like LisH-like dimerisation" evidence="15">
        <location>
            <begin position="7"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="112"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="154"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="199"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="246"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="329"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="352"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF24951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCI09569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="459" mass="50160" checksum="55836744B9D1F592" modified="2018-11-07" version="1">MSRTLPSKQAEELHKSIVAYLAANNLPNSAALLRDEAGLSEDVFDTATAKKYETLLEKKWTSIVRLQKKIMDLETRNAALQSELDNATPDSLSKRTQDPLSWLPRLPSRHTLESHRDIINCIAFHPTFTSIASGSDDSTIKIWDWELGELEQTIKGHTRAVLGLDYGGPRGAALLASCSSDLSIKLWDPADQYKNIRTLSGHDHSVSAVRFIPAGAQSSGNLLVSASGDKTLRIWDTTTGYCLKTLKGHTGWVRDVCPSLDGRFILSTASDHTARLWDISVPNPENKATMLGHDNVVRCCAFAPPCSYEHLAALAGLKRRPPATSAAEFMATGSRDKTIKLWDSRGTCIKTLIGHDNWVTAVAFHPSGKYLLSTADDRSIRCWDLSQDAKCVKVLSEAHQHFITCLRWAPGTSKDIINGVAAEAQNKKAAEAAVVTAPESIRCVIATGSVDMTLKIFAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L583</accession>
    <name>A0A367L583_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBL3-like ubiquitin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_3675</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000015">
        <property type="protein sequence ID" value="RCI09382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L583"/>
    <dbReference type="STRING" id="1330021.A0A367L583"/>
    <dbReference type="OrthoDB" id="1043111at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040015">
        <property type="entry name" value="UBL3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039540">
        <property type="entry name" value="UBL3-like_ubiquitin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13169:SF0">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13169">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 3 HCG-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13881">
        <property type="entry name" value="Rad60-SLD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBL3-like ubiquitin" evidence="2">
        <location>
            <begin position="155"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI09382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="252" mass="27438" checksum="440DAE1212FA4DC0" modified="2018-11-07" version="1">MDKTSEATAASHTQPVGEMVPMKDMAQLPSRLGDETEAGGRGGATAPSASHSDDDDDDDDDADDARRSRRLSKGKERDQDGTAKHRRESMAAIGPAQEDIRLAAPAGGDVGPVCIITLLLTSGSRHPYKIDSKYLARRNVIIPDENSDGYPDPFSISVYTLKELILREWRTDWEAKPNSPSSIRLIHFGKLLEDKEQLKKYQFSNENPNVVHMSIRPSDLDDEEPKTGGKSLPAGGGDGQRPRSGNGCCVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5R1</accession>
    <name>A0A367L5R1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyrroloquinoline quinone-dependent pyranose dehydrogenase beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_4058</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5R1"/>
    <dbReference type="STRING" id="1330021.A0A367L5R1"/>
    <dbReference type="OrthoDB" id="507128at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054539">
        <property type="entry name" value="Beta-prop_PDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH_b-prop"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22807">
        <property type="entry name" value="TrAA12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="Soluble quinoprotein glucose dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroloquinoline quinone-dependent pyranose dehydrogenase beta-propeller" evidence="2">
        <location>
            <begin position="18"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroloquinoline quinone-dependent pyranose dehydrogenase beta-propeller" evidence="2">
        <location>
            <begin position="262"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI09763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="481" mass="50863" checksum="CB49F9D6709D3DCE" modified="2018-11-07" version="1">MVALATTRVLAGAKLASAEGLSHGLVLDGLHKPRGLVEDSLGSLLVVERGKGILRLVLDGTGVGVASKGMVVNEGTLNHGIDLSADGRTLFASSSTDVYAWDYDANDGKAWNRRHLIAGMKQGGHETRTLLVPRHDANLLLVSRGSDGNVDMGTVKASSGRSQIRVFRIDDLLRRGPVGFEAGDVLGWGLRNSVGVAEDPTTGNIWSVENSLDNMHRQGQDIHQTNPGDELNFHGRPSNDNNKRQKGHSSSRSSRGDDDDDDDDYGRNFGYPGCVAIWDPSTVKNLVGVGPAAVTGQQITGDQVKGWNFTDEWCRSETVAPMLTLDAHLAPLDIDFHPDGSEAYVSMHGSWNRNPGVGYRLSRFAFGHDGFPLHNRSSRTAEKPMLWDVGGHCPGFLGGKNCFRPVGVAFASASPASASASASASASASASASASASASSSGGGGVPQQQRLFVTSDDTGELFVVTGEMGGAASRARVRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L641</accession>
    <name>A0A367L641_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI09893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L641"/>
    <dbReference type="STRING" id="1330021.A0A367L641"/>
    <dbReference type="OrthoDB" id="427960at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="135" mass="14655" checksum="1C2536EC22A94DFA" modified="2018-11-07" version="1">MAPETPRAVSSRLLTMRFMQRAAASASSDGVKKRKLDDSSALGRINTQIDEALIQAALDDQEATRQAALEKQKSADTHWKLEQWNAVKGKGSAISQLNVVYVGYGDIDSSRESGDTEDAPAKGRTSTRMGARSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6R3</accession>
    <name>A0A367L6R3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_8474</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6R3"/>
    <dbReference type="OrthoDB" id="422206at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049680">
        <property type="entry name" value="FLVCR1-2_SLC49-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10924:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 49 MEMBER A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI10099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="450" mass="48285" checksum="9ACC0233FEBB17CD" modified="2018-11-07" version="1">MNTITINNKDSKTETASEPTSQPAAYRTYNRRWFGLVQLSLMNMVVSVDWLTYAPVSEASSQYFNVSLTTINWLSTVFFLAFVLVSPIAIFAIHRGPKLAIVIAALLILVGNWVRYAGSSRPQRGSIVSALVGQLIVGFAQPFILAAPTRYSDLWFTDRGRVAATAMPSLANPLGGALAQLVISMLVKKAAAVSDLVLYVSIISTVCCLPAFFLPSRPPTPVGPSAEIPKLGFRQSLYVIRHSPELWIVFIPFAVNVGFFNSFSSLLNQIMVPYGYSNDDAGIGGAILIFVGLVVAAITSPLIDRTKAFVRTLKILLPLIALCYLVFIWMPETRSLVGPYIVLAVLGAASFASLPIALEFLTEVSHPLSPEVTSTIAWAAGQLFGAVFVLVSGALAQGPNATPPGNLKRALIFEGVIAAATCPLPLLLGLFGRKDKVALRRVGSRMGSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L716</accession>
    <name>A0A367L716_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L716"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="189" mass="18422" checksum="7BDFAAC9F2A6697A" modified="2018-11-07" version="1">MIEKEGLAAIKASPAAAINTSLAAAAAAINTSPSAAAAAINTSPAFPATAIDIYAATSGIAGRQEGVSRYTSRGEASSAYAAASLAPASISTNAFLAASHAASKAAYQISIGVIEAAATGPYRQALLTTIAAALVPLASFKAAAAASASKATAASSAAKEEETAEGLQPRLGRPALDAFSQGTPAITRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L906</accession>
    <name>A0A367L906_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5287</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L906"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="170" mass="18882" checksum="B6A6D60C392CF669" modified="2018-11-07" version="1">MQRARKKSRPNASNDSEGYLSLYKASSDALAALYIDSSLLEPRRATSSASREPSSARSSTSAGQSKGRLRTPDGDPSHLPLLDPTPNKGETARRPISGRNTLLKSIEEDYKETYLLPIINEKAAILDALYEVKHLAYKDAVALEIYDSLRLERSRDRNRTYDIAETNGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9C6</accession>
    <name>A0A367L9C6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_5279</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI11030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9C6"/>
    <dbReference type="STRING" id="1330021.A0A367L9C6"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19071">
        <property type="entry name" value="AKR_AKR1-5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000015">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF13">
        <property type="entry name" value="ALDO_KETO REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="6">
        <location>
            <begin position="35"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="5">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI11030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="280" mass="30858" checksum="046D3200C18D0A21" modified="2018-11-07" version="1">MAHSRSINDTVLVAASLRAPQLGFGVYKSPSSVCEASCQTALSSGYRRIDTAQFYDNEAEVGAAVRKSGLGRDAVWITTKILVPGATADESYLRCLESLDTLGPGGYVDEFLIHSPNVGGRDKRTETWRVLERLYREGKARCIGVSNFGVKHLEELRDEAVVWPPHVNQIELHPWLQQRETVAFCEKHGIVIEAYCPMARNSRADDRAVASVAAKHGVSPNQVLVRWSLQRGWVPLPKSDRPERIRANADVYRFELDEGDMAVVDGLDEGPAGALVMALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9J7</accession>
    <name>A0A367L9J7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_7750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the complex I NDUFA12 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9J7"/>
    <dbReference type="STRING" id="1330021.A0A367L9J7"/>
    <dbReference type="OrthoDB" id="274641at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007763">
        <property type="entry name" value="NDUFA12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12910:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12910">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT B17.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05071">
        <property type="entry name" value="NDUFA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI11089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="135" mass="15777" checksum="681C936681198B48" modified="2018-11-07" version="1">MSTISRTLRNLRKVGIKDYFRQMLVRDTKHGTLIGHDRFGNQFFENTEELPLRTRWVVYAKHDYDAAHIEPGWHAWMSYMVDRPPSEDALLASGKRPFEKSHHVPNYTLTRGAFKTYNTTKPKIATWTPVAAERT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9P2</accession>
    <name>A0A367L9P2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7727 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_7287</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9P2"/>
    <dbReference type="OrthoDB" id="2110422at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056144">
        <property type="entry name" value="DUF7727"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40629">
        <property type="entry name" value="PRO41 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40629:SF1">
        <property type="entry name" value="PRO41 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24853">
        <property type="entry name" value="DUF7727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7727" evidence="2">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI11126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="145" mass="16513" checksum="4033401D1E8E091A" modified="2018-11-07" version="1">MGKLIKNHWARLLVLTCALYQIGAAIEGFFWPQIFWDFLTSALNPAVKPVPILQIINLLFGIGLIALEWPVPFIAHTGVHRSIVFRLAILPLAALAAILMYQSFDDAIYYMIAMVAYFWAYSEGEIICAKPWTLPQREMRSPEKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LA30</accession>
    <name>A0A367LA30_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Prefoldin subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_7335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LA30"/>
    <dbReference type="STRING" id="1330021.A0A367LA30"/>
    <dbReference type="OrthoDB" id="10267474at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990113">
        <property type="term" value="P:RNA polymerase I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990114">
        <property type="term" value="P:RNA polymerase II core complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990115">
        <property type="term" value="P:RNA polymerase III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23157">
        <property type="entry name" value="Prefoldin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000004">
        <property type="entry name" value="Probable prefoldin subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011599">
        <property type="entry name" value="PFD_alpha_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00293">
        <property type="entry name" value="prefoldin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674:SF2">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI11279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="17648" checksum="5608454060C1F265" modified="2018-11-07" version="1">MAAERETPSHAVDLNTLEPAQLVQVKRQLDDELEHLTSSYAQLHGAQNRFKECLLCVRSRSSGPDASKSVLVPLTNSLYVRGELSNTDSFLVDVGTGFLVEKKLKSAEQFYERKSQEISTNLQGLESIVQRKQTNVKAVEDVLRQKLMASQGSPASATGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LA41</accession>
    <name>A0A367LA41_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LA41"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="80" mass="8480" checksum="9337568939B17D51" modified="2018-11-07" version="1" fragment="single">MKASTTTCLAGMSLKHEETMRAAGKGRAKKKRGLGRSVSWAGAALGDPRLTTAGPRLGAQRGGSRPTSFTFPSPRPHRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAW8</accession>
    <name>A0A367LAW8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAW8"/>
    <dbReference type="OrthoDB" id="5145552at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="367"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="398" mass="43741" checksum="7756ABD81450E7A3" modified="2018-11-07" version="1">MPRPSLQSSPPFPLDERVESNGHEPVTRPASLQHSTRAIQIETASPRLLPVPMNQHTGWEASNVPTAKCDLCQKQSRGVIQKCSQCKLSVCKTCAHDHRLQDDPRHALDPDAVDWKPPSSSAVRKTRPSPQKGRIRKRKSVTTAPGRRQLRERDRVPSKARFRPPPPSRKTSVPFNNVAGHETHSESPLTEAGRRHEDKLDASAAETAEIAAILAGMQRQPSSVNDGLHLPPVRSVNDTLQHDHLPSLRTLHPSLGVRKILETDGFSLPRPAVMVYGNLHRTSDVRHEAATHDDGGNQPDENAAWNHQQSDTFYHYPPIASDFGLANMTFSVSSATQGPVWQSHTVSRTPLPSRRPQHQGQQAAELSQTDQSTTASSSSSNAEGPLTTWENSASSRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LB94</accession>
    <name>A0A367LB94_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7573</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LB94"/>
    <dbReference type="STRING" id="1330021.A0A367LB94"/>
    <dbReference type="OrthoDB" id="3599317at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="26604" checksum="C6E6A88D1DDACC99" modified="2018-11-07" version="1">MHIKTASEAWNRLKELYNPVSFTSNFLLTKELLEIAIEEELKAWEIKIPEIVLITWVLNNLSELFQGFITYITQDLRNNEGSYNLGKLFAYILDKAKRYKSNYLEEGQALFTGTKKPWKKQKKALKCSYCKLPGHFNKDCYFLHQEKAPKHFKVKESNKITKRPRKEKALRKTQGTFGSSNIKATEEDRAKKIFITTNIDTAPIEIDIPDLPSAPTPGGIVEDTESEAEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBK2</accession>
    <name>A0A367LBK2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Alternative oxidase</fullName>
            <ecNumber evidence="17">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">L249_7372</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Catalyzes cyanide-resistant oxygen consumption. May increase respiration when the cytochrome respiratory pathway is restricted, or in response to low temperatures.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16 17">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="16 17">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the alternative oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="17"/>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBK2"/>
    <dbReference type="STRING" id="1330021.A0A367LBK2"/>
    <dbReference type="OrthoDB" id="16906at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098803">
        <property type="term" value="C:respiratory chain complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009916">
        <property type="term" value="F:alternative oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010230">
        <property type="term" value="P:alternative respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01053">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1260.140:FF:000002">
        <property type="entry name" value="Alternative oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.140">
        <property type="entry name" value="Alternative oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002680">
        <property type="entry name" value="AOX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038659">
        <property type="entry name" value="AOX_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803">
        <property type="entry name" value="ALTERNATIVE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803:SF3">
        <property type="entry name" value="ALTERNATIVE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01786">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005229">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 17" id="KW-0249">Electron transport</keyword>
    <keyword evidence="12 16 17" id="KW-0408">Iron</keyword>
    <keyword evidence="14 17 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 17" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 17 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR005229-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RCI11818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="367" mass="42400" checksum="82BE5E7F0E99730E" modified="2018-11-07" version="1">MHTTFRANLTYTTYPTSLASLMIFTTFQPQVNGSRYAIKLAHAVVIQNGRYRCCALRAGFLLPRQQFSTTPTTRLRDFFPVKDTPHILKTKPAWPHHGYTAEEMTAVVPAHRKPRNFSDWAAWKIVRMARYWMDKATGMDNEQQVDKKNPTTAVVAEKPLTEAQWLVRFVFLESIAGVPGMVAGMLRHLNSLRHMRRDNGWIETLLEESYNERMHLLTFMKMCEPGWFMKLMIIGAQGVFFNGLFIAYLLHPKVVHRFVGYLEEEAVHTYTRAIHEIDQGHLPKWSDSKFQIPDIAIGYWNMPQGHRTMRDLILYIRADEAGHRGVNHTLGNLNQKEDPNPFVSTFKDREAPKPSLKPAGYERTEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBQ9</accession>
    <name>A0A367LBQ9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7555</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBQ9"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI11841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="99" mass="10878" checksum="69E200CBBFE3A8C0" modified="2018-11-07" version="1">MTQRKYFFRCADIHKITSGPKKLSDNEAEKRAVVGSHRSISLTSVISLSFVSYERARPIAAASACFGAIAILPRASAPSVHISLPYPIFIRSNEIQAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBV8</accession>
    <name>A0A367LBV8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_4191</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000009">
        <property type="protein sequence ID" value="RCI11907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBV8"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI11907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="65" mass="7533" checksum="BF9C6CD60836E385" modified="2018-11-07" version="1" fragment="single">PEDEVTAFRISYEIFLDILDILYISGKKNPIANALSRKPTIEIDQIKREKDSDSKDFIDLYLNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCU5</accession>
    <name>A0A367LCU5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_1336</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCU5"/>
    <dbReference type="OrthoDB" id="4084551at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028000">
        <property type="entry name" value="Pma1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14610">
        <property type="entry name" value="Psg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016605045" evidence="3">
        <location>
            <begin position="21"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI12249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="370" mass="40961" checksum="1F258D0CE6584C67" modified="2018-11-07" version="1">MKKPILTTTTLAALTIAAAAATTSSSPPPPPSPIPTLPQHNPLSRRGDDDVTLSEQDFTTVPPTAPWVTIDDEGQPAMTVTPSIATVSGGTTTTVEHGAPHDLTASVFTWITWGAITTSTGTPPNPTALDAKTGQGAFSRCFNRDRDLAPFCRPLVNSTLLTGTAYYVTWDPDFYKTNDNTTLEIAIRIDYLNQTTNEWSKLDTYDRVPSKWGFWPLRLNTEHLKGQRYNNATITLVSSAKGSDESSKSAPLPVTFAALGVDDMPPPRVPKGSTLLIALPISLGSFFLVLIGLYLWHRKTRRIDLGNIMSRSRHGYSGRKQRRRRLLRSIRRQQEEDEPRVPLTDYHDRLSPIGHDEREKLPTTTYGQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCY9</accession>
    <name>A0A367LCY9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="5">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">L249_0553</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 24 25 26">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="5"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LCY9"/>
    <dbReference type="OrthoDB" id="361536at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03478">
        <property type="entry name" value="Rieske_AIFL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14385">
        <property type="entry name" value="UBA1_spUBP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14386">
        <property type="entry name" value="UBA2_UBP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000396">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000587">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050446">
        <property type="entry name" value="FAD-oxidoreductase/Apoptosis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041432">
        <property type="entry name" value="UBP13_Znf-UBP_var"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43557:SF2">
        <property type="entry name" value="RIESKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17807">
        <property type="entry name" value="zf-UBP_var"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="12" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0408">Iron</keyword>
    <keyword evidence="16" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 17" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Rieske" evidence="21">
        <location>
            <begin position="32"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="UBP-type" evidence="20">
        <location>
            <begin position="718"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="19">
        <location>
            <begin position="869"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="18">
        <location>
            <begin position="1102"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="18">
        <location>
            <begin position="1164"/>
            <end position="1204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="RCI12277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1292" mass="139361" checksum="8DCBD95169BE9599" modified="2018-11-07" version="1">MLARRLRIFRLPSRSVCPFSSSRLVMEKEYKLKDVSSLSLAPGMKREVEVEGIKDGRVLLLNSAGKVQAVGARCTHYGAPLAKGVLTASGRLTCPWHGACFNASTGDIEDAPGLDALPVFAVSERDGAVYITGDESAIVSSRRNPILGCAAATSAGVTADRVVVVGGGSGAMGLVQALRERGYNGSVTVISKERYLPIDRPKLSKALITDPTKLALRDRTWFEMASIDWVEGEVSGVDFAARSVTTKDGSVFPYGKLVLATGGAPRTLPLQGFKVLGNIFTLRTVPDAKDIVDAIGEKGKKIVIIGSSFIGMEAAIATCKDNTVTVVDMAKTPLERVLGEQVGDGIRKIAESKGIKFYMGAGIDKAEPSGSDPSKVGAVCLKDGTKLEADMVILGVGVAPATEFLRDNSVLRLEQDGSIKTNENFEVVGLKDVYALGDIATHPYHGPGGDGKPVRIEHWNVAQNSGRRAAAHIAQRPDGHGHSIPVFWSALGAQLRYCGNPVNGWDDLVLNGDVSEAKFVAYYAKGETVVAMASMGMDPTMAQSLELMTLGKMPSKSQLKGGLDIMDVGVPGLTQPPELSPPNASQSVYREDCTQCFDSIDEPSGLDVCLQCFNGACAGPRPHNGLHASLWKHPLALNIRRTRKPVVRDEPPAKISKLAIAAESDEDRYDTALSAKCLDCDALLDVTDPRLAPVVDGIIKANTFARKEEVKAWEQELTSCEHILLLQQHEARNIQQGDLGHCFACDLRENLWLCLECGNLGCGRKQMGGVDGNSHALAHATESTHGVAVKLGSITPEGTADVYCYKCDDERLDDQLGPHLAHWGIMLADRRKTEMSLTEMQIEQNLKWDFSMTTDDGKLLKPLFGPGLTGLKNLGNSCYLASMVQDPAADLETQLRKVADGLLSGRYAKPDDDEPEVSHQRGLAPAMLKHLIGRGHPDSLRDGRTGPGLDDPTKAFRFHLEQRLQCLGCGKVRYSTHEQDSIFIDVPLEKLPRAEGDAVDQYKPVSLKQCLESLTKAEKVELACSSCRGTEGFSKKSLFKTFPQVLVVNANKMSVINWVPVKVDVPVLVPDEPFLLDDYLSKGLQASEEPLPDEPEAAAPAFVPEAAALSQLEEMGFPRNRCEKALHATGNSDANAAMEWLFAHMEDADIDAPLDLGGGGASVAADPAKIEMLGAMGFDAPRAGKALKETGGDVERAVEWLFNHPSDVVEDEAAPAADEPAGSASLPASFQLRSLVCHKGTSIHAGHYVAFVRKQLEGEGAKWVLFNDEKVVEAHDVEEMRKFAYVYFFERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LD13</accession>
    <name>A0A367LD13_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_1318</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LD13"/>
    <dbReference type="STRING" id="1330021.A0A367LD13"/>
    <dbReference type="OrthoDB" id="1678912at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051864">
        <property type="term" value="F:histone H3K36 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032454">
        <property type="term" value="F:histone H3K9 demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694:SF7">
        <property type="entry name" value="[HISTONE H3]-TRIMETHYL-L-LYSINE(9) DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10694">
        <property type="entry name" value="LYSINE-SPECIFIC DEMETHYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="2">
        <location>
            <begin position="215"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="471"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI12305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="519" mass="56846" checksum="5E25CD97547DDA7D" modified="2018-11-07" version="1">MEEDEGGRRSAVVGAAEHPSVFRPASVTLPALAPVPPIDVLPFPTVSSPYARPISPSSSPSSSLSTSSLDHDQRKNNYNVDYDYDDVDGHHPILHLRPSLSQWHDFPAILDYAKTLGAESDGCFKVSIPECLRDPLPEKPAHRVPANAYKIRQIKKTTFWQVCTVPSDGEFGSDAVGPNSFHDSVAQAVKNLKRLFRTNKDRQMRSVRYRVDVPAWTATQRRAAGVPERSPIHPLKGDKLDHTRAIIPGIHTPYVYESGPYFGATFQIHAEDFRLASLNHLYKGRKIWIVVPATAVDVAEAALGRHEACSQFMRHRAEFFFPDKLDKLGIPYRLVDQRPGETMVILPDAYHEGFSTGYTIAEARNYADGNWNTDSYQPCQESCRLATAIPAALMRPLADGEERLDLCAAYGDDGRFIAPLPVVEPIPPPPPSPLPWTTTTTAMATTTPTPTPTPTPTPTPSTMTTATISNTTATMTPNPTTTTTTAAMTTTTTKRPLDESDAVPADAVDVKRVKTLAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LD20</accession>
    <name>A0A367LD20_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AMMECR1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_0062</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LD20"/>
    <dbReference type="STRING" id="1330021.A0A367LD20"/>
    <dbReference type="OrthoDB" id="24630at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.700.20">
        <property type="entry name" value="Hypothetical protein ph0010, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023473">
        <property type="entry name" value="AMMECR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036071">
        <property type="entry name" value="AMMECR1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002733">
        <property type="entry name" value="AMMECR1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027485">
        <property type="entry name" value="AMMECR1_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00296">
        <property type="entry name" value="TIGR00296 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016:SF0">
        <property type="entry name" value="AMME SYNDROME CANDIDATE GENE 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13016">
        <property type="entry name" value="AMMECR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01871">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143447">
        <property type="entry name" value="AMMECR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51112">
        <property type="entry name" value="AMMECR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMMECR1" evidence="2">
        <location>
            <begin position="60"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI12324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="268" mass="29399" checksum="5975B81D092B3BA7" modified="2018-11-07" version="1">MASAEHCLLCFDALEAYLDHRKPLPLDRIQSSWAAFSASDPPSSTPAVLKDPALRRVAASSSSSSSSSSSSSASSSSAASPALASTPATSTSSLPLIRPPTSTPLFVTWNTVSDDGDVSLRGCIGTFESQPLAIGIPDYAVTSAVQDSRFPPISKHEFSSLQAAVTLLTDFEDVDDFYDWEVGTHGIRLSFYDRGRKYGSTYLPDVASEQGWTKDETLYNLVRKAGWMGSRSRWKDLDLKVTRYQGNKFAMDFSEYKKWRDWMTASKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDA4</accession>
    <name>A0A367LDA4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDA4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="575"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="683" mass="74034" checksum="390B169EC5E25AB8" modified="2018-11-07" version="1">MAPPGEDSHPPFRFNPRPAAEASLRAEESARKMDEENLSLPRQAAGERMAVWQAQTHKPIRNGGEPALVRESLIDLGHGIGYHCGGGSRPDVLVRRVNGTSTAVGSAPRLLRISGQLTLPLFSSDPSATPIHNSIKACIKPVSTIDHPSPTRVYATPQTPSQHQGQGFPPLPLSFIQASAFLSPQLTSIINMLLCLLKYTNHSNNNHEPPRLPISSDHRGPPNTNLSTMLPPASARHGTPPAAMSGRASSLVEKKKASGEEERKIHPPAEPHMDESRIKRPQHGTARPGARRRHRAEKGPFASSFDRGAVSNHHRYFVITNLFPSCVTSIIVITIHHQFFPLIPTPSHPWKSTAPRLPPAAILTRRHQAEHDPEFRLSVLADPDPAATPSPGRLPMTTTAAGPLRLDPHICIVNAPVLGLVHRYAAVTDPVSTFCVNNLIDAEAPRIVSIPRSCWHAASVGSAFSHQGLSFRVDALQGRGERANESSLSLLGLICLLTISLSLSACLLKRLQRLCPTSHPEERKENHVIPCCTLRIKHFVHPAVPGRTPLSKMRLGTIHRKYVIDFASASTSFQKQRRRLAQPPTGSNPPLATSRRAARHRLEGKEIHGTTASSVLGTLSELPAPYISLYPVLSSSPFHAHLFVDCPALPSIAQYITTLAGLAIGPCVKGLPGSRLVPSTQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDT5</accession>
    <name>A0A367LDT5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CHCH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_0813</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFA8 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDT5"/>
    <dbReference type="STRING" id="1330021.A0A367LDT5"/>
    <dbReference type="OrthoDB" id="276296at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010625">
        <property type="entry name" value="CHCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016680">
        <property type="entry name" value="NDUFA8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13344:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13344">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06747">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CHCH" evidence="10">
        <location>
            <begin position="131"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI12593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="217" mass="24484" checksum="50CE7BBCC686876A" modified="2018-11-07" version="1" fragment="single">DGNINQSAPANCGSLNYNLTCPASESQKLPRRSLGGRRFNMAARRPQFNQELLLDRTPLPDAIPAVKEVGASSAPLLSAAFFIGARCRPYNDDYMQCKTDKPGRGEFDCMKEGRRVTRCAQSVIRDMNAHCLAEFRKHWECLDDRNHQLWQCRPAEWKLNKCVYDNLKLEKKIPDQPTNVTPVELRTKQIFADVRIRASDGKPFVAGQSEKEAATGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDZ0</accession>
    <name>A0A367LDZ0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mitochondrial transcription factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_0168</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Mitochondrial transcription factor that confers selective promoter recognition on the core subunit of the yeast mitochondrial RNA polymerase. Interacts with DNA in a non-specific manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDZ0"/>
    <dbReference type="OrthoDB" id="29072at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034245">
        <property type="term" value="C:mitochondrial DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034246">
        <property type="term" value="F:mitochondrial transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006391">
        <property type="term" value="P:transcription initiation at mitochondrial promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="entry name" value="Ribosomal RNA adenine dimethylase-like, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727:SF17">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI12645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="937" mass="107807" checksum="E6D826CD6B83677D" modified="2018-11-07" version="1">MSSCRYSEYDGTTKSQKMATRERDWSNGLPVSAQSRICTAKVPEPQSEGFMFTAVKYGSTTSARQLRRPIAVYVPLKGFERNYGVKRVEPPPSPSDIYIKHLMKTGYSERGRKKNKDQLKDPRRVNIVNPGLCDDIVNYIGPSLERHRGCDLIDINPGVCLWSERLHSFLEPRKHILLEPDVERYADFLRPLIAKPQVTLTTKSGLVWKDLVEVIATELPQQRPMDHDAVPTRNDTLLVTANLSTWPKKAHRSFDSISTMVIYQFLSSIRTSSLFQRYGLVRMLLWIDDDEKKRLLPRSVTRRRRSAFELETSCEWFREVASMDTLVEDRLALRDKWINVESGCNVIKKMEAQGLQMPADRQPKAYSDLKQEFSKYADLKLAGAKLPWLPRPFKQELDEIEQEMDEDTPRGGLSGVRWRRRVVLRKLLKLDAEGAELSHRLLQQAEVISRLATESPSEFEAADAAWNEEVEKLKKNQRMSFNNLKNNLHVFRKDPPALHWDRRVYEPLTVRATEFYPSEAPTALLDIQPKAMHPLLRQYGIGTDRSGDVSDVMLRKWFLAMSHSMHQAMDTIWPGASELVAQCPSMTDARRGGSPMTGHGSLKARVLTEDQWIEMLQAWMDWPFRPTYEQLVGQALPRTDNTLLEEDDSAKNGLLCLTGGGGTSMESSERSKAEVVCSYVQVVLFCSVSLLEASARLRFDAESNETPNDDSMIVSPIWLQRHESFHFPCIDHWLRVDERRSCPVCKATVSRVEYGQDGLGCEYRPLSLRRRGRRRVPTETDEPDGLTFRRHVYLRLRYSLYMGSNRHSGYRELDRLAFRRDQGLQSRAKAFLRRELRVFCWLTSPDSPSPSSPRRRRRPTATVERLVGHMVFLLCHFEIRGSDGALEDIVTTFLGREIARLLLHELHSFLRSPFESLTEWDVHVQYPPIDAGPAERQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEE6</accession>
    <name>A0A367LEE6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FHA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_0092</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEE6"/>
    <dbReference type="STRING" id="1330021.A0A367LEE6"/>
    <dbReference type="OrthoDB" id="444265at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22676">
        <property type="entry name" value="FHA_SNIP1_DDL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050923">
        <property type="entry name" value="Cell_Proc_Reg/RNA_Proc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23308">
        <property type="entry name" value="NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="244"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI12790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="338" mass="37749" checksum="6F2F92CD9C95ACC9" modified="2018-11-07" version="1">MTAAAKDVSDVLTLRIDGSETTTTTGHETVANENETGTKETGTNENVTKETGANDTELHSIIKLESQADDDRYNQVKQRVNHQSRHEGDDEGDEICRPKHRSRDGDSRRSRATHGNDGDDGGHYRSPIVKRESIKRESDDEAAADAEPRRQKEPRAPLASQEESFALENGEGASKVKEKPNWTNTGALAAASNSVVQADGSSTTLKYHEPVESRKPPPRDDWKLFVFKGNDIVDEVPLSLKSCWLIGRDANVVDILAEHPSISKQHAVIQFRYTEKRNEYGDKVGRTKPYLLDLESINGSMLNDYAVPHSRYLELRPKDMILFGNSTRQYIVMLAPHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEP7</accession>
    <name>A0A367LEP7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH-ubiquinone oxidoreductase 9.5 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEP7"/>
    <dbReference type="STRING" id="1330021.A0A367LEP7"/>
    <dbReference type="OrthoDB" id="2093409at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22903">
        <property type="entry name" value="NI9M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039961">
        <property type="entry name" value="Nuo9.5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38488">
        <property type="entry name" value="OXIDOREDUCTASE 9.5 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G08980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38488:SF1">
        <property type="entry name" value="OXIDOREDUCTASE 9.5 KDA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G08980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="16442" checksum="F5BC4EA99FA389F7" modified="2018-11-07" version="1" fragment="single">LRSAQPCINASQPRDLSLNEVTTVHHHHHHHDAIYSHCHPIVRHQRQKKKKKKKRLFAMSPSTPYFWSAPFKYCRWACRERPAYFWSVIIGAAGPIAMPIVPPLRHYYGDIDPPPVPVTYPVPTGPRKVLTGFDDEEADSQKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LES8</accession>
    <name>A0A367LES8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_0931</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LES8"/>
    <dbReference type="OrthoDB" id="43458at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018908">
        <property type="entry name" value="TMEM234"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28668">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28668:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10639">
        <property type="entry name" value="TMEM234"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI12934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="165" mass="17882" checksum="A79263458BF1059D" modified="2018-11-07" version="1">MASPPPAINYILSFVLVGLAWGLTTPFIRRAARRRQQSRPAAAAAATAEDESSSSMKNRLWSACVSVWDFVRDPSYSLPLLLNLSGSLWFFLLVGRAASNPRFRPSGLGFLLVELSLTVPIVNTLAFLFTVLGEWFVEGKVISKRTASGVVLSLAGIALCVHSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LF16</accession>
    <name>A0A367LF16_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_1095</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the actin family. ARP2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LF16"/>
    <dbReference type="STRING" id="1330021.A0A367LF16"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10220">
        <property type="entry name" value="ASKHA_NBD_Arp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000050">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000005">
        <property type="entry name" value="Actin-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="363"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="424"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="13">
        <location>
            <begin position="16"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI13018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="866" mass="93859" checksum="D3A886ED3A1F13E0" modified="2018-11-07" version="1">MAGRCSRSITAYLILIIAIATLGSLQFGYHLAELNAPQDVITCRKKSVSTAGRLSAWLHSSQSPSNCIPMSEATFATISSVFTLGGLAGALASGPFSSRRGRRLTMRLTAAVYLVGSLVEALAANAPVMALGRFLSGLGAGASTVVVPLYVSEISPPAERGLFGAMTQISINVGILVTQVLGYFLSHGRDWRWILGAGAVIAAVQAVGLFRAPESPIWLAAHGDVTVAKHTMQRIRGNSLDIHQEVESWGHNDRSEHEGLLPTVDEAAPSSPSQPAAKAPCHLGFTEVVMDARYRPAIVALVGIMIAQQFCGINAVIMYSVSLFADVFPTSSALLTIIISAVNLIMTTASAPLPDRLGRKTCLLLSAVGQGTSALLLALSIVFGVKVLSAIVVLFFVAFFAVGLGPVPFMLASELVDQEAVGAAQSWCLASNYVGTFLVAQFFPIINTALNDALGGSGWAFFLFAALAAGSSLFVFVKVPETRVLDGGTGFLKVGYAAQNFPEFQFPSIVGRPILRSEEKTDNDLVIKDIMCGDDAAAARTMLQISYPMENGIVKKWDDMQHLWDYTFFEKLKVDTNGQKILLTEPPMNPLKNREQMCEVMFDRYGFGGVYVAIQAVLALYAQGLSSGVVVDSGDGVTHIVPVYESVVLNHLTKRLDVAGRDVTRNLIKLLLRRGYALNRTADFETVRQIKEKLCYVSYDLELDKGLSEDTTVLVENYTLPDGRVIRVGSERFEAPECLFQPHLVDSESPGLGEFLFNTIQSADVDIRASLFKAIVLSGGSSMYPGLPSRLEKELKQLWLTRALQGNPERLNKFKVRIEDPPRRRHMVFLGGAVLANIMADNESMWVTKAEWDEQGPRVLDKLGPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LG19</accession>
    <name>A0A367LG19_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_0863</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LG19"/>
    <dbReference type="STRING" id="1330021.A0A367LG19"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd18626">
        <property type="entry name" value="CD_eEF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000076">
        <property type="entry name" value="Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.990:FF:000002">
        <property type="entry name" value="mRNA export factor elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000193">
        <property type="entry name" value="Probable Elongation factor 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015688">
        <property type="entry name" value="eEF3_ABC2_chromodomain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047038">
        <property type="entry name" value="eEF3_chromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF14">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="458"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="703"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1064"/>
            <end position="1084"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI13361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1084" mass="118977" checksum="31BC98E16D74606B" modified="2018-11-07" version="1">MASPTPQDVAAFIDTIFTAKTSAASVEASYGLCDLLLRSGDLDGLQRHGILDEVRKAAADKKNGLRRESAQNLLGAVLERFPPRQPVSEVFLVCNDDGPLTCALDALSDKGAVVREAAQYGLDALMANLSPEALVAGLLPALSRYLGRKTGKWQGTVGAYKMLQTMADKAQVSVGATKAEAADKDLLRDAMGAKLAGLIPLVEGGMHDLKAEVEKQAVRTMNSLTTLLSNDDVAPRIPLLVDTMQHPSAQTLQKAIHALSQTTFVAIVTSPVLALLTPFLERSLNSPNTAQEVLRQTVVIVENLTKLVHDPIEARAFLPKLTPGVKAVCDRASLPEVRELASRALATMEKAMGEDGDIIARTTADDVAKLLDDQVKKHNGVAAVDMYKLVRPYVCEMVAIDVNNRYVQRIADRIAPYLKPLMREPGTAEKAAGAVQKHYVEEDRRRYGVPEKEDDGEVEIVNADFSLAYGGMLLLSHTNLRLLKGHRYGLCGRNGAGKSTLMRSIANGKLEGFPPQDVLRTCYVEHNQGEDADMSILDFVSKDPTIAPQGTARIAEVLAEFGFTAGPEGRQAQKVGSLSGGWKMKLALARAMLQKADVLLLDEPTNHLDVANIAWLEEYLKSHTDITSLIVSHDSGFLDNVTTDIYHYEPNKKLSCYRGNLASFVKVRPEAKSYYTLSASNVQFKFPPPGILTGVKSQTRAIIRMSNVSYTYPKATKPSLSDVSCQLSLSSRVAIIGPNGAGKSTLIKLLTGEVIPSSGRVEKHPNLRIGYIKQHALEHVEMHLEKTPNQYLQWRYANGDDREVHMKQTRVLSDKDREQMDRWVELGDGKAARQIEALVGRQKFKKSFQYEVKWRGLLPKHNTMVSRETLTGLGFDKLVQEFDDHEASREGLGYRELQPSVISRHFDDLGLDPEIANHNEIGSLSGGQKVKVVIAGAMWNNPHLLVLDEPTNFLDRDSLGGLAVAIRDFKGGVILISHNEEFVGALCSEQWHVHDGRVALRGNAALSLDRFDDSAVASAASSVPSSAVTSGVEDNADMAFRARKKKKMTKKEVKEREVRRRLRHIEWLNSPKGTPKPADTDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGJ6</accession>
    <name>A0A367LGJ6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGJ6"/>
    <dbReference type="OrthoDB" id="10577650at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="362" mass="40257" checksum="59738EC5854D02B6" modified="2018-11-07" version="1">MDPIQIHPPGQQRKHAHQIPRRTKQMEEPIIPSPKEGEEESIIDNFEAGYDNLIDLPARYRDCPQRVPRISQSDLLEAAPCPFTYKVVTMSHRMLVLLASFAICLLLWPSHCEAKPLSDGMEAISTGTWSGHHRSASHGFGLSSIPPPRPSSPPRLPPAQHDNVAPLPAVAPPEPTNPPLPPSSEDLDEVPSMPPPPVPEEPQASAISEPKQESPVPDETTSEQKLNETMSTSKSSNRFFRHAYSRISRMMKKPKQKSKSETSAPKPQGQEATSQSESASPQVYPRPRRGALVRFSRKEQKGKDQAQASSSKPHEQMAEMPGPSWRQPQYLPRNVAGTLKRKETRKETDPLFLHPQLRGVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LH34</accession>
    <name>A0A367LH34_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycerophosphocholine acyltransferase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L249_8153</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GPC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LH34"/>
    <dbReference type="OrthoDB" id="406287at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021261">
        <property type="entry name" value="GPCAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31201:SF1">
        <property type="entry name" value="GLYCEROPHOSPHOCHOLINE ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31201">
        <property type="entry name" value="OS01G0585100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10998">
        <property type="entry name" value="DUF2838"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="28"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="459"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="481"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCI13720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="554" mass="63436" checksum="01F739B48F28405F" modified="2018-11-07" version="1">MVPDQQPSPEPKELDTCFDDTEADILMQPGLSTDEAASPVLEASESSRRRLSRNPSCSESSSHHDDWDSLPPLDRLTVLDILDNLALPQQLEKLQKGISAQTEKVRRSKDAFKSRTQLARDRMVEEWRRRVPSADEQLERYKKRMRRRVDKLGQHWSDTKAISIREKISFICGVMNIFISGFLIGGYPQYFHIWYTAQLIYFLPVRFFTYHRQGYHYFLADLCYFVNVLLSLSIWVFPSSKRLFTAAYCLTFGNNAIAIIMWRNSLVFHSLDKVTSLFIHIMPCATLHCLVHLLPSEQQEQRFPAIWTVKNSTPGSPTAYANMSSMLAWSTIPYAFWQLSYYFLITVRRRDKIAAGRPTSFTWLRRSYAQTWIGKLVMSLPDRLHEPVFMFIQYSYAVLTMLPCPLWFANRRASAIFLFVLFAWSIYNGSTYYIDVFGKRFQKELEAMKAEVSKWQNTPELGVQSPLMTPHNEKPPGIPAHNSTPKDTNPSAETKHHDGLASGDAVGHEVNAASSASLERIPLLDESQTKPTQEGAAAQNVTHRRNLDVDAEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LH80</accession>
    <name>A0A367LH80_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein-arginine deiminase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_7989</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LH80"/>
    <dbReference type="STRING" id="1330021.A0A367LH80"/>
    <dbReference type="OrthoDB" id="5102063at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004668">
        <property type="term" value="F:protein-arginine deiminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004303">
        <property type="entry name" value="PAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013530">
        <property type="entry name" value="PAD_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10837">
        <property type="entry name" value="PEPTIDYLARGININE DEIMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10837:SF8">
        <property type="entry name" value="PROTEIN-ARGININE DEIMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03068">
        <property type="entry name" value="PAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein-arginine deiminase C-terminal" evidence="2">
        <location>
            <begin position="211"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI13770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="639" mass="71959" checksum="EA8EF52887AC37FB" modified="2018-11-07" version="1">MLAAGQQHSVATTSSKADIRADSNRDGKVDIESSTDIAGKHNWSDTAGALFLSNIGDTDRRCSQMTKLPSFIHDPHQGDVLADVMAACHDAVDDVQRAPHLMAPIRTVPIRGLSPSAVGTISVSDHLARKLVRIFRPRGDDDDTWDIVTNETTFSSKHLTRGLQLGIDARTTRGFSGYMRLSNGKVKIRDEPPWDGRATVHFTVTDEGNTWSDFVMLRVAPVLSHHHLQKIDTVMTGKPLVSNSSYSRQRYKERMAMVSGLQQSMKNAGLESPLHIFQHSDAYWPQDFFEPGYQSMPGPNGTIGLRIVMFPQYHVRQTPYLMRELRAAGVGAVRDPSHPGVTKAPANHMINLDAGGNLETIPPYEHKGKKYPNGRIIMGGVDEQGKFPYMLSYLRAQEAQDPLLVDSLWLDVQHLDEFLQFVPANTTRGWRLAYADTESPVTALRKAQAKGFGSVWLEREPKRKDPENADRRHTIDDFLRSEAYLEANKESARRIRKAVELVVEETGLTEDETFGVPVLYRRRFRRRYEIPGFKAGRKRPGANATESPQRRNEARDRGMVSIFPSAINGIVLTASHYVAPKQYGPLVDGKDIMEEMARGVYARMGFDVDFIEDMYFARHQGDVHCATNTFRDMRGRWWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHB4</accession>
    <name>A0A367LHB4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHB4"/>
    <dbReference type="OrthoDB" id="4540290at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016696076" evidence="1">
        <location>
            <begin position="26"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="347" mass="36800" checksum="6A0353FCB098CFE9" modified="2018-11-07" version="1">MHTSRDRLLSLLLTLAVFFLSFAAAAPQKNGNRQINGGGNGGQSKRDRAIANVPEGISQANDGSTILDTTQQINGLPIRYRISAPAQFFTQNSGVQGAQATPGSTGQMGINVLLHGDGGQSFFDFPNQGVRNNIMGVAVLSPDSGMRWGGADQRNQPRPDGPAHSQAVADLITKVMPQMVAFDNKQVHFTGVSGGSLLLTGSFMPAHMDKFPNSKVLAGCAAMAPQVQFTPQAQQAMASTRLHFQSTVNELESLQTTIPQSITAYKQVVTNAGLNDQQLGALQTANNSPKGGHCAFDEKNFISGVQLMADSFGNIMLDGGNGQLGKFGDVRQSVVGANLQFGQERRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHC3</accession>
    <name>A0A367LHC3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_8006</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHC3"/>
    <dbReference type="STRING" id="1330021.A0A367LHC3"/>
    <dbReference type="OrthoDB" id="10056939at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008422">
        <property type="entry name" value="KN_HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050224">
        <property type="entry name" value="TALE_homeobox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11850">
        <property type="entry name" value="HOMEOBOX PROTEIN TRANSCRIPTION FACTORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05920">
        <property type="entry name" value="Homeobox_KN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 4" id="KW-0371">Homeobox</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="6">
        <location>
            <begin position="333"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="4">
        <location>
            <begin position="335"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="112"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="254"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="414"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="254"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI13811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="455" mass="51617" checksum="58741E37583464EB" modified="2018-11-07" version="1">MDRSPRRHNNDDNNNNNNNNNNNDDDGVYSTRYRMSILAMHTPPTPHSIFRSPAEWDLPWSDCARPRTENQTIALPPIRQTIPELHMSLDKAVLDGRHLAFRSPTVLGSLASPEYVHSPNGNKRRRVSMDDESVVPLHSQIPRLCRSPDRPFPRQLSSPRREVPMSASTTGTWASPTRSSPLSSATGPGPVEISGGRLETRPMIKKLECPPMTIQDGRGGEAGGAESLVALDSSRHHLYHHHQPFRLHDYSQAYHHHHHHHHHHHQQQQQQQQQQQQQQQQQQQQPPHNHAANRHQSLSAVSSGRSLLHELGGPTAVYHHPQYPGEVVVGADSKQRKRRGNLPKETTDKLRAWFVAHLHHPYPTEEEKQELMRRTGLQMNQISNWFINARRRQLPAMMNSVRAESEVMRVVGPPGPELDYGKGGLPLSDGEGCAYDDDMRGLRKRRAGELSRESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHM6</accession>
    <name>A0A367LHM6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Xanthine/uracil permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_8200</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHM6"/>
    <dbReference type="STRING" id="1330021.A0A367LHM6"/>
    <dbReference type="OrthoDB" id="431212at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005345">
        <property type="term" value="F:purine nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015853">
        <property type="term" value="P:adenine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015854">
        <property type="term" value="P:guanine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337:SF3">
        <property type="entry name" value="PURINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="XANTHINE/URACIL PERMEASE C887.17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="385"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="422"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="473"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="497"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="559"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="559"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI13897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="583" mass="62854" checksum="24DC3AD5E8781345" modified="2018-11-07" version="1">MAQAEFQQQNPPSGRSTVFGFRDFFDFADRRLTTSRFGRLFRLSGTGHPNEIHDTTFIREFRAGLTTFTTMAYIIAVNASLLSQTGGTCVCDQRPHALCDTDPHFRACKEGSRDLITATAAIAGMASIVFGALTNLPVALAPGMGLNAYFAFQVVGVNGSGSVSYKSALTAVFFEGIIFVVLALTGLRQWLVRLIPATIKTATGVGIGLFLAEIGLSYSVGIGAITGGGRSTPLALGGCPLELIDPLSGMCRSGLMTSPKMWIGVVCGGIVTSFLMAFRVKYAFVIGIAIVSVLSWPRHTSISYFPDSDEGNARFDFFQQVVAWHPVRRVANSLDWSFEAGASHFALALFTFLYVDIIDATATLYSMARFCGVANRRDGDFPRSTVAYCTDAAFISIGALLGSSPVTVFIESGAGIAEGGRTGLTAIVAGLCFITSVFFAPIFASIPPWATGCTLILVGCMMMRQISLINWHYFGDVLPSFVVIAFIPFSYSVAYGLIAGLFVYAVLNGLVGLVVLISGGRIEPREYELKEYWTWKGGGRPPWFVRAIDAHRKRRDAVRELETDDGRDSRADSAAKEYPVAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHP6</accession>
    <name>A0A367LHP6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_8224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHP6"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI13917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="80" mass="9105" checksum="7B2B4B46424CA3A4" modified="2018-11-07" version="1">MAKEEGGGLSRRLLWAGDLPLPSNLHVRMLPQAKLAVEDRVYPSAWKHGNVMEQQHQVCALHPKRVNAQRHGSLFFSFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHS8</accession>
    <name>A0A367LHS8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Probable dipeptidyl-aminopeptidase B</fullName>
            <ecNumber evidence="5">3.4.14.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">L249_8303</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.</text>
            <dbReference type="EC" id="3.4.14.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Vacuole membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S9B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.5" evidence="5"/>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHS8"/>
    <dbReference type="STRING" id="1330021.A0A367LHS8"/>
    <dbReference type="OrthoDB" id="16520at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000003">
        <property type="entry name" value="Dipeptidyl peptidase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.140.10.30">
        <property type="entry name" value="Dipeptidylpeptidase IV, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050278">
        <property type="entry name" value="Serine_Prot_S9B/DPPIV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731:SF200">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 10, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731">
        <property type="entry name" value="PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0720">Serine protease</keyword>
    <keyword evidence="13" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="10 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Dipeptidylpeptidase IV N-terminal" evidence="20">
        <location>
            <begin position="240"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="19">
        <location>
            <begin position="716"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RCI13978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="946" mass="103903" checksum="296FEC61566903BD" modified="2018-11-07" version="1">MALEADDSLSSVSTTSLVFDRLQEEMEKPRMMRKTGSRRDANDVDDDDDDFDQEEDQPDAGNDEAGPFLASSTTTTAAAGGASAASVVDADRRRGFKPMDRRLRRGIIAVVSVVVALWLVALTLFATGSYKHVVGGGSDEENASSSSSSSADKMPVSLDEILTGYWYPRSRSISWIAGPDGRDGLLLEEGAPGKDYLVVEDVRSWADGDEAAADGPRTLMKSSIFVYEGTRYSPDWLEPSPDLSKVLLAVDREKLWRHSFTAVYFILHVASGRVEPLVPHNDTARVQLASWSPSSDALSFTLDNDLYVRRLLGNDSAADRVTTDGGPEYFYGVPDWVYEEEVLSDRTATWWSSDGRHLAFLRTNETAVRTFPIDYYLHRPSGTSPAPGDEAYPETRHIKYPKPGSSNPTVDVLFYDTAERVAFPVPGADAFADDDRIVGHVLWAGNDGVLIKQTNRVGDHQRTVLVDVAARTARVVHDVDGAAIDGGWLDLSRRTAFVPADPDKGRPLDGYVDTVIHQGFEHLAYFTPLDAAEPTTMLTSGPWEVDSAPAAVDLANNLVYLVAARQGPTQRHVYSVRLLDGSGLEPLTPVEDEAYYDASFSAGAGFALVSYHGPDVPSQRVVSTPSASRRDADLVPAKGFVVEDNSELASRVRSHALPRLRRAYMDMGDGLSLSYLERRPPPSPRPTPHHHQRRLPVLFHQYSGPGSQSVTHRFAVDFQSYVASSLGYIVITVDPRGTGFRGRRHRVPVRSHLGVIEADDLSSFARAYASRNSEEVDPARLAIWGWSYGGFQTLKTLEHDAGRTFSYGLAVAPVTDWRLYDSIYTERYMRLPSDNGPGYDASAVTNASALGGCARFLVMHGTADDNVHFQNSLRLLDGLDRAGVENYDVHVFPDSDHSITFHSANRIVYDKLNTWLINAFNGEWLKVKNPQPIPRSLGPVSSSSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LI50</accession>
    <name>A0A367LI50_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ketopantoate reductase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_8251</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI14091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LI50"/>
    <dbReference type="STRING" id="1330021.A0A367LI50"/>
    <dbReference type="OrthoDB" id="5302359at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000017">
        <property type="entry name" value="2-dehydropantoate 2-reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000424">
        <property type="entry name" value="Meiotically up-regulated gene 72 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051402">
        <property type="entry name" value="KPR-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708">
        <property type="entry name" value="PROBABLE 2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21708:SF25">
        <property type="entry name" value="PROTEIN PAM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="2">
        <location>
            <begin position="11"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="3">
        <location>
            <begin position="214"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="645"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="589"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="747"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="767"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI14091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="784" mass="84991" checksum="4A3D5D8C42204506" modified="2018-11-07" version="1">MAPIAPRLKVLSVGGNPVSAFLSWRLQATNACDVTLVWKSGFEHVAQYGRPFSVTRDSSLAMVRSQNPKLAEDGLLTPHTVVQNPEDASNARDGPFDYVVLCVKALPDVYDLAAVIDAVVTPQHTCILINTTHTLGVESAIEERYPTNIVLSLVSGAELTQLGPSEFEHKGSTELWVGPANKNSSIPHSIQEDMAQALAMTLSTGQVQCKVSPNIRQHQYERVIGPIAFHPVSVIFETPNHASLFEKVGVKELVSEVIDELLRLAEATGCKFSTEFKQRIMDEMTKPNLPESIMWQDYVARRPMEVETYLGSPIKLARDNRVPVPRIETLYALLHNVNTINRNRPKPAEPTAQQPPPGPVPPGTPTMTSPLPRAPSQQSHRPMLSNMTNGSGMPPPRQPRPRNSTNFPPGGMRRPPPMNGPPPAGYSRPPPSINGGGSRAPSRRNSIEGNDLEEFSHLVLYDDIPEGQEPAFSSGEADLALRERELQLRQRELALREQEMRMRRGPPPGARRGPHPMRNSHQAFEDDDDDDEFFDPAASTGGTTPTIDPDNFDMMSVTSRKTRKAPGPSAAQFRRNPEFDAPLPPRGGGRFRPHFGRSRPNHGGHAAASTDNILDDPMMSFTSNRYATVDRGAMGANSRANSLTASRLDELQYSHGGPPGMNGAYPRRSSQSPGNPYASSMRGGGGGRPSPPNGYGPPMNGRPSPPDGVRQPVPRYPSGQGNSVAPQRVEQHVGVSALRPPKPRNVRSLTGSASVSAGSGELDSEPSAHSSQSSLQNGPTIGVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LI71</accession>
    <name>A0A367LI71_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Partial AB-hydrolase lipase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_8019</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI14077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LI71"/>
    <dbReference type="STRING" id="1330021.A0A367LI71"/>
    <dbReference type="OrthoDB" id="6130531at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000193">
        <property type="entry name" value="Ab-hydrolase associated lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006693">
        <property type="entry name" value="AB_hydrolase_lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04083">
        <property type="entry name" value="Abhydro_lipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Partial AB-hydrolase lipase" evidence="3">
        <location>
            <begin position="229"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI14077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="647" mass="73830" checksum="F3D933FE482609B0" modified="2018-11-07" version="1">MDVPWPAGHHARHAKPFNSNGRTVLKASNLTRFSRKLSTSGSSSGTIPAHLVTPKNCVSSSPDAGRVCEQDFAGSKDEEALCLQTHSPNEIVSLPQPQISAKDVLRISSYTHPLFPPLPLYGPPSLTRTAKCLFYRLSSFCLSLSFLGVIVAGSLLSSVPNLCRKLYVLDGDRRRPFYDEEQRRSDIRRRARKNWERRASAGRPGQNDEETADEYPPTEGGKDPIVCDVSYYARRVGLDAETMEVQTEDGFILELWHVYDPKEKKRAAHKEPGEKGRRFPVLLMHGLLQSSGAYCCNDDESLAFWLCKSGFDVWLGNNRCGFRPRHQTLNYGDPRMWCWNIRQMGVLDLPALTARVVAETGFAKIGLVCHSQGTTQTMVALAKEQRPELGDRLTVFCGLAPAAYAGPLVGKVYFKFMRVISPAMFRLVFGVHAFIPFMMRMHRLLPPRVYGWLGYKVFSYLFDWSDARWDRELRDRMFQFAPVYVSAESMRWWLGRESFAKHKCILATGEGEGEGDSNELMGQESTDEAAWYDERAPPFALWVCGNDDLVDGRRLLRRFDQGREPHVRVVHSRVVDEYEHLDVIWAMDAVDQVFKEVREVLWKTCDVRDECRVPTGCEAVEAWKGERVMKGREREEGRDEERERWHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIM9</accession>
    <name>A0A367LIM9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_6172</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIM9"/>
    <dbReference type="STRING" id="1330021.A0A367LIM9"/>
    <dbReference type="OrthoDB" id="441444at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005290">
        <property type="entry name" value="Ribosomal_uS15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15, BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321:SF26">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="135"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="267"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI14260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="371" mass="41478" checksum="56CA8EE8D386B306" modified="2018-11-07" version="1">MPPRLGALQRLATLKLFTPPIAARLLLPLVPAASISRKEKARKLRRMDPYRREQMEQRKNAHLKRREEIYEQRAIEWGDPVWGSVTPTPFCESFASAGQQATIVVPKKEEDTESDGDGAAEAGAGGEAVVRAIGDKASSSKSSSSSSSSSSSSSSTDEANSSESDAQDPPPTEVRDLPTSFHLRNYLVDGEELDEALQHAYVITRPKERTVGDSLDPLPPQRSHEENHERAKLAMQRIMAIENGNAKNRFHVNVQRILEEFGRHETDKFLTPKPPSIDKAPEPVPRAGPDTGSSEVQIAILTVKIRKLATELNKEGNRKDQHNKTNLRKLVHRRQRLLQYMLRKERGSGRWTHMIEKLGLTPATWEGQITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIN6</accession>
    <name>A0A367LIN6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Asl1-like glycosyl hydrolase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_6137</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIN6"/>
    <dbReference type="STRING" id="1330021.A0A367LIN6"/>
    <dbReference type="OrthoDB" id="43654at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071966">
        <property type="term" value="P:fungal-type cell wall polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF10">
        <property type="entry name" value="ASL1-LIKE GLYCOSYL HYDROLASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016652937" description="Asl1-like glycosyl hydrolase catalytic domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="3">
        <location>
            <begin position="143"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI14281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="380" mass="40565" checksum="4D0156B7CDBBBB15" modified="2018-11-07" version="1">MFVNKIVAIAALAALTEQALAFNSHHHLHRRRIGAPKHTRWVTYVTTVTVDPPQQPGYSKPTPAPAHSRPKAHKAVAAAPAPPPVRNAAEAVAPPPVPKPVASLLQPVASYLPPLVQPPSPVKPSYGGKAHAGSGPVFSGKRGLAYNEATLANHFDDQCNGCSVWAYNWGSSPQGLAGNISYVPMLWGNKPMFIDHWQSDAQKAVDNGAKAMLSFNEPDNGGQAKMSPEQAAQLHVQHMNPWGGKALIGSPAVTNSGQPGEGLQWLEGFLKACDGRQEKCRVDFCVVHWYSQPQYADTLYDHIAKAHKLCGGKPVWLTEFGPVDAAGQPADAAAFLKEVIPKLDAIDYLHAYAPFMCSAGKLMSSANALSETGKVYAGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJ63</accession>
    <name>A0A367LJ63_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_6188</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJ63"/>
    <dbReference type="STRING" id="1330021.A0A367LJ63"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032161">
        <property type="term" value="C:cleavage apparatus septin structure"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005940">
        <property type="term" value="C:septin ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000921">
        <property type="term" value="P:septin ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043934">
        <property type="term" value="P:sporulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000260">
        <property type="entry name" value="Cell division control 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="7">
        <location>
            <begin position="31"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="309"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="328"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI14417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="338" mass="38494" checksum="E7D25781C80F9802" modified="2018-11-07" version="1">MATMPPSTILPQNYVGFDSITTQIEKKLLKRGFQFNVICVGQTGLGKSTLINTIFASHLIDSKGRMMPEEPIRTTTEIQAVSHIIEENGVRLRLNIVDTPGYGDLVNNDRCWDPIVKYIKDQHSAFLRKELTAQRERYIQDTRIHCCLFFIQPSGHSLKPIDIVVLKKLSDVVNVVPVIAKADTLTTSERLAFKERIKEEFAFHNLKMFPYDNEEFDEEERALSGKIKSLVPFAVVGSEKSIIVNGQQVRGRQNRWGVINVEDENHCEFVYLRNFLLRTHLQELIETTSQTHYETFRAKQLLALKENSAHGGASSRPISPAADRELSRSSQRMAMNGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJ85</accession>
    <name>A0A367LJ85_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_6098</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LJ85"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF49">
        <property type="entry name" value="SYNTHASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="8">
        <location>
            <begin position="13"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="9">
        <location>
            <begin position="672"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="7">
        <location>
            <begin position="672"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="7">
        <location>
            <begin position="810"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="7">
        <location>
            <position position="704"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="7">
        <location>
            <position position="869"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI14484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1849" mass="201386" checksum="D848B146EC435187" modified="2018-11-07" version="1">MNGTIKHSIKSDHEAIAVIGMAMRLPGGVRSGDDFWKMLAEKRSGLSKYPPNRMNPSGHLDCPTGMEAHFLQDVDIREFDPSVFPMPRKELAQLDPVQRQLLTVTYECMEDAGSMPQDDTNKIGCYVGASYSDWKELHDVDTLQSGSYRMTGTSLFTMANRISYEFDLHGPSTNAMFVPSASAQEALIRRAYDEAGIEDLGQTAMFECHGTGTAVGDVVETEAVGRCFGKDGVIITSVKPNVGHSEPASGITSLIKAILAIERRQVPPNILFETPNPNVPFEQYKLHVPVEVEQWPEGRAERVSVSSYGVGGANAHVIVDSLAQYRCDQAKSHSLAWSLLTPNKSESHGTQLLVLSAASDASLGKLVDSYQAYVKDDKVPLADVSFTLARRRRHKAHRAYAIAEAGELLHVSAGQDSPTPSRILWVFNGQGSQWAGMGAELLDANPVFRELRKTAGFSLVGKAELMATLIVAVQIGLIDVLRSWKITPDMVVGHSSGEIAAAYASGAITAQAAISAAFFRGASCSETEQAGAMAAVGLGPLEVAPYLEAGVVIACKNSQTNVTLSGDAGQVDKVVRKLKQSLPDVLIRRLKVEMAYHSHHMLKCGAKYEEKMFSLFDSVEPAVAFFSSNTGDRLKGEHSLGPAYWRANLENPVEFNAAVRSALGQEGDRVLIIEIGPHHTLRGPLGQIVKDMGRQGDVPWLTGHKIGDQILLPAAASIAMVGEALRQLKGKRAYSLRNVSLSAALTVPAVETVQVVTSLTRELLDVKNPWYSFTISSHDGFAWTRCVSGEARAGIDVMPPNKSHGKASFERVVDEGTWYKSVGNLGYNYDGLFRGLREVKASPVRRSAAATAPSVAGDEGYAIHPVTIDFCLQAMMVAFAQGLLLDYSNLVESLAHRNPRMKVLEVGAGTCATTAKMLRMLTSAQGRPMYESYLITDISAGFMVAAKERFADYQGVEYGAFDITRDPKEQGLNADYNLIIATNVVHATPNLTATLRNLRGLLSNEGRLFLTELNTGTFSTLPLSPGTVSHVLTLQLARGQVYKLRNGQWPASLEVCRRTHNRMQGFLPGWWEGVDDGRELEPYITPDKWGKRLLSAGFRQPYIVESDDESPYGTMTTMIAAPQIAMDPPAAVTLLCHKKDGPYVQELTDSLQARGIFAEVCIFGQPLPRQDTFCLLDLQSPILHDLNETSFGILINYLKILQQSDMMIWVTPASQTSCQDPRCGLINGFARSVRTEIKLRLYTIELDAQSQTPNATSAAILTDLYLHSRKPRSSGKVMRPDCEFAIVDGNVLVPRLDWMSWGDAWARSASQHNDNCALIIGKPGSLQTIEWTAEEREEPGHGEVIVKVKAIGINFRDVVSALGLICLPHPRVGFEGSGVVVEVGEGVQELSVGDRVFFIAKDGVSSYTRISQARCRKFGDDLRFEEAAGVPTAFATVVAAIVDKARMSPGQTILIHSACGAVGLAAIQVARLQDAKVSGFGHGFVVFLTLRSNEKRDFLVRQYGIPTSHIFYSRDSSFLHDIMEATGGRGVDVVLNSLAGDLLQASWKCVAKFGTMIELGKMDMRRRQKLDMSVFEDNRTFTGLSVDMFDDSMFDSLFTRTASWLASGAIRCFPVTNMWGFDQAQEAFKAMLQGNHIGKMTISVPDDVSSIPTIPQMTARLRLRPDHSYLLVGGTGGLGMATSTWLAEKGARHLIFLSRSAGNTSACHNLIDELGALGCAVQMVRGDAANPADVEKAVKQAAKPIAGVINFAMVLKNIDVFNMTFSDWSEVFAPKVRGTWNLHNLVTTDLDFFVLCSSICGVVGKAGQVNYSACGSFLDSFVKFRRQKGLVASVIDLGAVAGYLQFKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJB7</accession>
    <name>A0A367LJB7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_6499</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJB7"/>
    <dbReference type="STRING" id="1330021.A0A367LJB7"/>
    <dbReference type="OrthoDB" id="1368at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044669">
        <property type="entry name" value="YneE/VCCN1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281">
        <property type="entry name" value="UPF0187 PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33281:SF19">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION CHANNEL-FORMING PROTEIN YNEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25539">
        <property type="entry name" value="Bestrophin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="335"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI14533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="468" mass="51625" checksum="2BEDBA327C8E62A0" modified="2018-11-07" version="1">MDDKSGNSPETPPASPPASPPAPSVFDPAARHHHAGSGPRASLDLNDYFTGPRDMARHSRWPLILRLHGSIMPKLILPVGLISIWSAAITIISINVHYLGVHSVLLTLTGFVVSLSLSFRCSTAYERYSEGRKYWTGLVQASHVLGRVFWIHAKDAPEIDPRECLLLRLSSMNLLVAFALSLKHGLRFEPYVYPEMAQLVAHLDTFAASATDAEEQASSPRRRRFFRSVGEYIGLSFTASNPRKALKRASRPLGHLPLEILGHLAVAIDALVADQQLTVPAHQTLAYNALQSLNDVMTGTERVLCTPLPIAYTIAISQATYLYLALLPFQLIPLLHWIAIPATIAASCIILSLLFIGQEIEDPFGHDVNDLPLDSYCDQIAADLDIIASLDTRNARAFLTSRRNLPLYPVSTAPYDVWLQRDEEKLRSAIRQKPVARFEWTRWGAGKVGSVSASSSFATQKDVEQGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJP2</accession>
    <name>A0A367LJP2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nucleoporin Nup159/Nup146 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_6372</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LJP2"/>
    <dbReference type="OrthoDB" id="248320at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000645">
        <property type="entry name" value="Putative nuclear pore complex subunit Nup159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026054">
        <property type="entry name" value="Nucleoporin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039462">
        <property type="entry name" value="Nup159/Nup146_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23193">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23193:SF23">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16755">
        <property type="entry name" value="Beta-prop_NUP159_NUP214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup159/Nup146 N-terminal" evidence="6">
        <location>
            <begin position="47"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="483"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="646"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1339"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1207"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="646"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="703"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="721"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="808"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="855"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="911"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="927"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1007"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1339"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1370"/>
            <end position="1380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI14620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1432" mass="150170" checksum="50525DED8D81F164" modified="2018-11-07" version="1">MAAPFGASANAVNTGPDLETIQTEALGFLSVAGDAKVRLTSPWSDLPASTSTLLSIASRKGLVAAAGPDQVVIARTDAVRKALESPKEGDSDVRTLENNKIITPMPMRISQLAFTADENYLILSAEAGGGLAVYEVQSFAQGIAQPSFELATGGESLRSLVPNPTPEKAELCAVVTNGGNLHMANLKERRISNALRSQVSCISWSAKGKQLCAGLADGTIHQMTPDGEAKAEIPRPPSLVGDYHVSSLTWLENNLFLAIHTTTNLSPPSSIYNIITREPPAAFVFQKMSDPVEPFNLDKAPYHSILRLREFPPDIQDLLIVASTASTDIGLLSRSRAPLAGNRDPNPITGVFTTTELLDDNKRPILPMTDSMDGSTPVGVTLDLSSRDKVCKPIPSDEELEESPGPLPGLWVLTHEGLLCAWWVVYTESIKKRTTFPGLAATEGIAVTPSNQAVQTAPSSLFSSSGQGAPSAFGSTAAAGPAFGASSQLGQKPSPWGSAAPMASPSTGTPVFGSNSFGAPAASGSTFGKPSAIGFGKSTQLGMRESPWAKEGSAASPFGSSGFASFANSTNNQTTASPSSGGFASFAKESGFGAVAANNSSGSSVFGSGSKLHGSSVFGNAGGSSFLPPKPAGSVFGSSPFKLESSFKADQSQKESNQKPSGAPGTSMFGSTFGSALIDDGANTALTPVPKDEVMDTGEAPEQTPQAAPSSAPFSKLNRESSTTPTSSPAPARFGLSSSPAPGTMLFGQPTKLSGSGGLFGSGSQSPKPSGFPGIFGAPKENPKASVEPEAQKIKIEEAEESLPPDVSSKTNLSLGESTSTEATSSVPKEPLQTSAAGSTAEAAPLPPDFLTPKKTATTLEHNSVPSNGAVDEVKQSEDADDAPLPPDFLKSSKPQAQTASPIPDFPNEAASKSSPQEPSAVSLGPDADEASSDFEDDNASEGSGVDVAEDLSPSGGERTPTMGFTPHSSFGGRAAEGSTPAADRAGQAQRRTLFGEIGRNAPTFLPPSATSPRSPSPMRSSVPQRMWPSEAARSVSAPNVASQVLGFGKSLGASTVSKETMAKAEQSFIQQNRKIKARQEEEEAQPLVDEDDDELQKVLASEVEGKLDLDEFIAYSNVAPPGKDSIPSQVEAVYRDINSMIDTLGLNARSVTAFLKGHTEGAKEGGRSKADLEMPDDWVLCEVPELGAILDKELYEDLEDGRVQDLDDKLDACHEMTRDMQRLRAKQEDLRRVMVARLDPDQVEVARALPLSAEQAAQQNELRRQIGVFGKLLAQAEETLTLLKTRIASASGSSAKGFNSMPTVEAVMRTITKLTSMAEKQSGDVDVLETQMRKMGLGTSSREASPMVTPQSKIAAASTPTHRFRHSLSGSVSVGSAGARATPPRKKLSGFSKDELEDLKEERARRRAVLDRLRKCIETKGVQVWNMEDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LK98</accession>
    <name>A0A367LK98_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Cytidine deaminase</fullName>
            <ecNumber evidence="4 13">3.5.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 13">Cytidine aminohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L249_6720</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 13">This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2'-deoxycytidine + H2O + H(+) = 2'-deoxyuridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:13433"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15698"/>
            <dbReference type="ChEBI" id="CHEBI:16450"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 13">
            <text>cytidine + H2O + H(+) = uridine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16069"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.5" evidence="4 13"/>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LK98"/>
    <dbReference type="STRING" id="1330021.A0A367LK98"/>
    <dbReference type="OrthoDB" id="414540at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004126">
        <property type="term" value="F:cytidine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055086">
        <property type="term" value="P:nucleobase-containing small molecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072527">
        <property type="term" value="P:pyrimidine-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01283">
        <property type="entry name" value="cytidine_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000008">
        <property type="entry name" value="Cytidine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050202">
        <property type="entry name" value="Cyt/Deoxycyt_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006262">
        <property type="entry name" value="Cyt_deam_tetra"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01354">
        <property type="entry name" value="cyt_deam_tetra"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004064">
        <property type="entry name" value="PRK05578.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11644">
        <property type="entry name" value="CYTIDINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11644:SF2">
        <property type="entry name" value="CYTIDINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12 13" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="14">
        <location>
            <begin position="26"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="68"/>
            <end position="74"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606262-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCI14856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="161" mass="16828" checksum="51DEB0E811D512C3" modified="2018-11-07" version="1">MPPPNSTEATAAAAATAAAAAMLPPPTLQELTRQAKEAKSKAYCPYSNFRVGAAVLSQDGETVTTGANVENASYPVGTCAERVALARAVVETGETRFRALAVATDVSPAASPCGMCRQFIREFGDAGMLIVLVAADDRVEVVTLEQLLPMSFGPEHLSTRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKD0</accession>
    <name>A0A367LKD0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKD0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="414" mass="46872" checksum="41045B82B44FF62E" modified="2018-11-07" version="1" fragment="single">MFLGSFAYINIPKPKAPPPPSTPPPLIPGSPDSKTCLGLAEQEKPRGRRTLLSTDDSCFEFCLHHLTEDVVCCPLSYVILKLCAVPVRRVSKEPSFLFIKKDSLDRDAGVTKPRKLIPHGFNCKSSGNRMLFLCLLAVLSGELGFLVVVVLLDNSHTAISPFEMHSLKPILLLLLISLSSRLTIAHPSATNRQIMQPCPYGIGGHILRCRSDYLWGFLQPNRRVRMLADSEGQWQLQFLDRDRKPTSWHELENHKCYRLKNLCLPSRTMPVKAPNTLWLRCVDQWRGGTLTFKERRTRTGLQLTDSSGRTIPPTTRGSTNPWCNYREGHDGPSFTFPEGLDGTIRHSFSFVRRNGNPTIKLSYMRDEPNSSRDAKLVRSAVRKDVFSNGRPRDLAFRRGVEVKLHSFLQEPDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLC5</accession>
    <name>A0A367LLC5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">OPT family small oligopeptide transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_6442</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLC5"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="289"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="492"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="519"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="566"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="607"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="640"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="670"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="748"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI15200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="812" mass="90477" checksum="9D333F8D41BA4CA6" modified="2018-11-07" version="1">MASSSSSAAAGAAEATGIEAATRLSRRRSDSLSDDDLAFLGDDDPMQRPAEAENAPLMEEDDDRRDEAFELDDWQHLHDDQSRPKATDEEEDQDSPYAEVRAAVRNYDEDLPCGTIRAWAIGLLLVLVGASTNTLFSLRQPSISVGDLVAQILAWPLGHGWARFMPDWHLRLLGRRWRLNPGPFNVKEASVIAVMASVSFSVAYSTDIILAQLVFYKQDFGLMFQMLLTVSTQSLGYGIAGAMRKFLVIPAGMVWPATLVNVAMINVIYSYENNDRPDRSFIGGSMPRYRWFGIVTAASFIYFFIPGFLAQFLSAFVFLTWMAPQNAVVNQLFGGTTGLSLLPVTFDWTQIAGWVGSPLIPPWSAIANVIIGVVVFYVAGSSLLHYSGAWYAEFLPISDANTYDNTGKPYNTSRVLTPEFTLDEDAYRAYSPLFISTSFAMAYGLSFAAISSLIVHTFLHYRKQIWKQYRNSSGEKPDIHMRLMSRYVEVPASWYLSLFVAMLALGLYTVLAYPTKLSWWAYLLAVSISCGFALPIGIIEAICSNQIGLNVLTEFVYGYIQPGRPLALMIFKTFGYITMSQALRFVADLKFGHYMKIPPRTMFSAQVVATTLSCIVQIVTLNLALVSIEDVCDSQQRDRFTCPGGRVFFSASVIWGLIGPDRMFSPGRIYSGLFLFFILGAITPVIIHLVSKRYPRSPARFLMAPLIFGGAGAIPPATPLNYFSWATVGFVFQYWIKKRHFGWWSRLNFLTSCGLDLGLALATLFVFFAFSMHGIRPPRWWGNTVVSTTMDVQGTAVRAHVTEGEHFGPDVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLP0</accession>
    <name>A0A367LLP0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">Autophagy-related protein 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_6501</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Autophagy-specific protein that functions in response to autophagy-inducing signals as a scaffold to recruit other ATG proteins to organize preautophagosomal structure (PAS) formation. Modulates the timing and magnitude of the autophagy response, such as the size of the sequestering vesicles. Plays particularly a role in pexophagy and nucleophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Preautophagosomal structure membrane</location>
            <topology evidence="6">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ATG17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLP0"/>
    <dbReference type="STRING" id="1330021.A0A367LLP0"/>
    <dbReference type="OrthoDB" id="1937984at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007240">
        <property type="entry name" value="Atg17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045326">
        <property type="entry name" value="ATG17-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28005">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28005:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04108">
        <property type="entry name" value="ATG17_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Autophagy protein ATG17-like" evidence="8">
        <location>
            <begin position="56"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI15355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="486" mass="53395" checksum="EE7761F8F6C4E336" modified="2018-11-07" version="1">MAVSSAASSRRSAASSAASLRRSADRQQQQQQHQPATTAVVSADVLVSHLLVAKRSLSSMSLVLRANEIATAARAAHEDTVMLAAHMRFLRGSMADQVALLKRLRRGFQATYEWGKRDFKKLIRAMDEADGKLGSTMEMLRGTEVQDEMRPTGEERRNLLDFVDETGVHAMREAMKKSIEELQGIQQSFDRDLVRFDGDIRHLKKATAEGQQPAAAADNEAGASAELLLSLEDHSATMAQLLASLTKHFDMCVTAIRTTEGAAALARRRAAEVTQSQEGDGVSISGVIAEGESGSGGVVGDLEPETAQDRAEMLRVVTQDAGEVEDVVGEIQQRLTEMERSSSILEDRRRWAEDGHGRASEAFSVLSEVGSRLADYLSAEEQFRARWEMEKDSVIGRLGDMAEMRDFYEGYGSAYASLLLELERRRSVERQVEAIWRKARDGVDRLLEADREARDTFRANVGDFLPAEWAGVGTTGGSEVEDIAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLU2</accession>
    <name>A0A367LLU2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Delta(14)-sterol reductase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">C-14 sterol reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Sterol C14-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_6561</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLU2"/>
    <dbReference type="STRING" id="1330021.A0A367LLU2"/>
    <dbReference type="OrthoDB" id="10262235at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050613">
        <property type="term" value="F:Delta14-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001171">
        <property type="entry name" value="ERG24_DHCR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018083">
        <property type="entry name" value="Sterol_reductase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF52">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE TM7SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01222">
        <property type="entry name" value="ERG4_ERG24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01017">
        <property type="entry name" value="STEROL_REDUCT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01018">
        <property type="entry name" value="STEROL_REDUCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="12 13" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8 13" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="431"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU369120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI15381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="483" mass="53767" checksum="00C2F11AC3B9558C" modified="2018-11-07" version="1">MAPNTAVEHGYEFFGPPGAFGISFGLPLLVYAFTFVCNDISGCPAPALLSPSTLSLDELKHQVGWPEDGIWGLASWKATGALLAYYALNMVLYRILPATHVQGTVLASGGRLKYKLNTMYSNSVTLAVLAAGTAARGAEFVVWRFIDENLVQLLTASIVISYAISTFVYVRSFGVKQGNKEGRELAAGGRSGNLLYDWFIGRELNPRVVIPLIGEVDIKEWCELRPGMMGWIILNCAWCARQYRNFGYVTDSIVCITVVQAVYTIDSWWNEAAILTTMDITTDGFGMMLAFGDLVWLPFVYSLQTRYLSVHPLSLGPVGLLAMLGLIGAGFYIFRSANSQKNMFRTNPTDPTVAHLEYLETKAGSRLLTTGWWGVARHINYLGDWIQSWPYSLPTGLAGYQVLTAGTTGHSEGGAYVMRDGRKVVAGDARGWGMLVTYFYIVYFAVLLIHRDRRDDEKCQRKYGDDWTKYKKIVRWRIVPGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLY9</accession>
    <name>A0A367LLY9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLY9"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="149" mass="17125" checksum="AB59DB6AAAA97C28" modified="2018-11-07" version="1">MRLYGIRYEAKGKNRKIREDSSSSLEGLPLIRARDIRFVNRARLSAIIDDPSIEFKARLEEEERDQSKGRLKTPEGDPSYLPLLDPTPNKGETARRPINEKAAILDALYEVKYLAYGDAIALEIYDSLRLERSRDRNRTYNIAETNGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLZ6</accession>
    <name>A0A367LLZ6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLZ6"/>
    <dbReference type="STRING" id="1330021.A0A367LLZ6"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018853">
        <property type="entry name" value="DUF2457"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10446">
        <property type="entry name" value="DUF2457"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="458"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="742" mass="83371" checksum="40B0F464C412A147" modified="2018-11-07" version="1">MNTINNCPSFTLDALTSATPDLDTADDVDEPPEIRLQQPSPQRFQRTAIRPHGLHSSLLTKAIMGHSDDDHHDYTTVNNQRRRSMTSTISIASTADLSSDTGLTSPCRTNTPSPPLPEIGLMRLDVNDVKEKTPPKKRCIQFACAAKPQPPAAPAQVPRRSCIKFAAHASESSVKPDSSPPEDPPTVVIPPSQPLSLRKSVSNSPLIRPKFIRANSKDPYNDASQFHEFASGTAREEEWIRKGHPLAETTKITINDTLIKENRFRRLAAEAEEEEDQEAEAEADDQADEPDDDDDDDGDEDEEEDQDDGEDQDDDSNGYSTDEETGFAESDDEDDDDENMTLWTPGRVANRIAAVPTRRGSSAEPQSDSSAAATDNIRPIKTRRHKDSDETPDLPDSTDFVCGTLDEDKPLEEAYLSCMAARRNGKLRIIPQDIDPSFPASDPDDDDDDEDMYNPVAHDSDSDVLVHGEMEDLHHGQDRSRRTLRSAAPPKRHIHSPPPPKRHHIHHSPPPQKRHIHSPPPPKRHHIHHSPPPQKRHIHSPPPPKRHHIHHSPPPQKRHHHSPPPPLHHHHHHPHHHHHNNNNNNDAAAPRTPSPKTLFGRQSPRRARSPAPRALMTPVGSPRQGPHVQFQLAGRPNTTHTKSLPRTAALFRHAKKERNVSKSYHHHHDADMHVRGAIDIVKGLERKRQRRKEKFYQKYCNRARRGQIPERKPQPGRGAERMKELGLLMAGKKDQGNYVISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMJ2</accession>
    <name>A0A367LMJ2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chitinase</fullName>
            <ecNumber evidence="4">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L249_3376</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="4"/>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMJ2"/>
    <dbReference type="STRING" id="1330021.A0A367LMJ2"/>
    <dbReference type="OrthoDB" id="4924273at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06548">
        <property type="entry name" value="GH18_chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF384">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016793083" description="chitinase" evidence="13">
        <location>
            <begin position="19"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="14">
        <location>
            <begin position="158"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="23"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
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    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
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    </evidence>
    <sequence length="535" mass="57774" checksum="A51B2AA46D7018C0" modified="2018-11-07" version="1">MFQPLLLTLLLLGRIAAGSDYDDDACPSDPSNGAPSKQGVGHAYAAGGHHRPVDLGSEVPPDVSRASTSNAQAHKVQGQANPYQVSVSAAAVHNVVGGPWTNSSHSEPAAENPASLTTMTTAIKPPASLVAPQAQRSKAAAAHHPAVPASKSQPFQLPAASIYGDAKYEMKQVPADNVTHLFYAFAVVNKTGGVISYDPNADIGSVSGNKVHGCVEQMFALKHEHRYLKTILSIGGWRASQEGQFKPVVTDEGRKEFVTSAVALMNDWGMDGLDIDWEYPQNEEEAVALKKLLQACREELDHLQTSQKQSYHYLLTAATPAGPSRYNLMNLAEMDPYLDGWNLMAYDYAGSWDDKTGHQANLYADARNPDATQFSTDKAVRDYIARNVTANKIRLGLPLYGRTFANTAGLGKAFVGTGVPEANAGVMLYREIPTSGSGSHVQVSKDVGAAWSYDEGKRMLVSHDTVQSTQFKAEYVRKLNLGGAFFWEASGDKTGPDSLVNTMAGELSALEKTKNQLSYPNSRYDNIRNGMPNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMJ8</accession>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
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        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="RRM"/>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMK5</accession>
    <name>A0A367LMK5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Involucrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
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            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR40641">
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            <begin position="2417"/>
            <end position="2443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="2987"/>
            <end position="2998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="3045"/>
            <end position="3058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="3134"/>
            <end position="3144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="3163"/>
            <end position="3175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="3176"/>
            <end position="3190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="3192"/>
            <end position="3212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="3230"/>
            <end position="3248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="3480"/>
            <end position="3495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="3527"/>
            <end position="3538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="3598"/>
            <end position="3609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="3635"/>
            <end position="3658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="3797"/>
            <end position="3811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="3853"/>
            <end position="3863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="3935"/>
            <end position="3944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="4015"/>
            <end position="4026"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="4095"/>
            <end position="4104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="4123"/>
            <end position="4137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="4143"/>
            <end position="4155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="4164"/>
            <end position="4176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="4239"/>
            <end position="4251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="4275"/>
            <end position="4292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="4359"/>
            <end position="4370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="4391"/>
            <end position="4409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="4898" mass="526358" checksum="2A9AEE36DF538D32" modified="2018-11-07" version="1">[encoded data, 4898 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMT5</accession>
    <name>A0A367LMT5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Non-specific serine/threonine protein kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_2056</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Associates with DNA double-strand breaks.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. TRA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LMT5"/>
    <dbReference type="OrthoDB" id="5570127at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05163">
        <property type="entry name" value="PIKK_TRRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046807">
        <property type="entry name" value="Tra1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046805">
        <property type="entry name" value="Tra1_ring"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF1">
        <property type="entry name" value="TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20175">
        <property type="entry name" value="Tra1_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20206">
        <property type="entry name" value="Tra1_ring"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAT" evidence="6">
        <location>
            <begin position="2667"/>
            <end position="3224"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="5">
        <location>
            <begin position="3473"/>
            <end position="3799"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="7">
        <location>
            <begin position="3796"/>
            <end position="3828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="162"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2022"/>
            <end position="2048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="3240"/>
            <end position="3283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="3240"/>
            <end position="3261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="3262"/>
            <end position="3272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="3273"/>
            <end position="3283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI15754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="3828" mass="438046" checksum="9342081841EF8F51" modified="2018-11-07" version="1">MAGTTIDDVVRRLSTAELDARLKLEAATTLRDSLDHYTSGSIYPPFLKRLIPIFLNILRGPCIFQSNSSEQKLRHCILEVLHRLPTQPAPTEPFEPYAEEVCDLLMHLVRTDNEDNATLCVKITCDIMRHQNKVLQGKVQAFLSLIQELFEQMDKVVREQLDNAPSTAASQPGAPSTPGSSQMSFQSPRPGSPVASVSDLGVDPQQQNRSLLRGMQSFKVLSECPIIVVSIFQVYRNTVTQNVKAFVPLIKGVLLLEASAQRQAHADAAAKGQIFTGVSPAIKNRAAFGEFITAQVKTMSFLAYLLRQYAQQLTDFLPTLPDVVVRLLKDCPREKSGTRKELLIAIRHIINYNFRKIFLPKIDELLDERTLTGDGLTVYETMRPLAFSMLADLIHHVRDSLSPEQIRKTVEVYTRNLLDNFPGTSFQTMSAKLLLNMAECIARLPNKVNARHYLIMILNAIADKFAAMNRQYPNAVKLSKQYHQQAMAGTPESYLADKDSRPDWDETDIFSAVPIKISNPRERGADPLVDNKFLFRNLLNGLKNTFYQLRTCNIGTPIDPENAPAHWHDVSYGFTAEEVNVIIKLFREGTYVFRYYEIEKPATESQYMSPVEYMANFYMISSSKEEKDLIETFATVFHCIDPATFHEVFQQEIPRLYDMIFEHTALLHIPQFFLASEATSPSFCGMLLQFLMERIDQVGSADVKKSSILLRLFKLAFMAVTLFAGQNEQVLLPHVVNIVAKSIELSTKAEEPMNYFLLLRSLFRSIGGGKFEQLYKQILPLLEMLLDVLNNLLMAARKPSERDLYVELCLTVPARLSHLLPHLSFLMRPLVVALRAGTDLVGQGLRTLELCVDNLTADYLDPIMAPVIDELMNALFNHLKPHPYSHFHAHTTMRILGKLGGRNRKFMSGAVPLTCKTYADDSSSFDVRLIGSKKDRAFPADLGIDSAVQKLMEAPRMGKASQNRQYDEYYKEQALHFITAQLKLRIGYDQLPEDLPRIVRIQAQDLMNRKMDISLAPFETSHRDKSIAKKDEQDKITKQLIKAIMFAETIPCFKDKADAFLLDICRHFAIIEVGRSLVDIKRTFSPFDPRAGEGPLHIETRVLSDAIVESLASDHPDLREAAMRAIRELWRCAAVIFGSEASVGRLPLFSHLSSTLCHSCYEEEWFTKTGGSLGINFLLTELDFGDAWVTSKQTEFIRALMYVIKDMPQDLPEKTRCLAQTSLEVLLRRITKNINKEDALPVFQPQGQPQVKQPRLAQICLQFNNELSHMNKFVRETARLSLELIAKAAGCEVWELLEPYRERFLQPIYSKPLRALPFSIQIGYINAMTYHMSLRSDWVKFDENLNRLLMESLALADANDESLANKPAEFRTHDNIVNLRVSCIKLLCTAMTFEEFANNPCKGKVLAVFFKCLYSESKPTINAANDALKAVLAVDRRLPKDLLQGGLRPVLQSLSDPKRLTVHGLDNLSRLLKLLTSYFKVEIGSRLLDQIDSIVEPSAWQQISFTFFEQNQQTKVITAILNIFHLLPPQAETFKEVLIDCFLGLEEKLRRTMHSPFRQPIYLYINRYPKEIWAYLLGRLDDMKYGRLLAQVLRHPDSIPLREVATEKVEALIQRCNEAMGQGMEKKFTAIVNTVHVLDSISQWPANNGWMDRRENITRLKMVGKDIESHLRSYALPANLRLPAYQASEQLMSILVKSLDRNPRDLDALFNLIELVTNEELRPTQALFSLIYNNIICSESIDFWKTTFLRCLEIYSSKTALNKTKHFLLHYIVSPIVAMDVMRHWNQGESSGTQRLMDRSVIDAVSTRIWKVHPEMSADDQAQPGIDHTRFEVLQLSAMLVKYHHVLLQEARKDIIKFGWTFIRLDDVINKNAAYVVIGYFIAHYETPPKIVNQVYISLLKTNQNEGRALVTQALELIAPVLPKRCGSGPNERNAAWAVAPRRILADEGQNVQQMTSIFHFLVRHPELFFEARDKYAILLITSLRKVAAPPNPSHESRKLALNMMWLIWTWEQWRVEGRKPAVRDDSLSPKSRKRKADGEQSPTALRQPAVGAHDYQIPPVFRQKMIKYLVEFIAQLNERYQLPSAKPREHNQSSVPLPPPNTELCKKALSLLYNLVQPQYWGDLELDLFPNVTDVILGSDKTQAILNADPADKEKYDERFLTNIINTLQVVRIVLCFKSDDWVQKHTAALQKVLERCLKCENPEIQDCLHLSDKNYDDERELKSIIQRVLDAVPEDTPMEDADAEAEGEAQTSEIVSYLSQAATEAMNNGSYISGVNLLWSLGKRKPAIIDQHVASLMKALQSKHAREHVQYYNAVATQAAASGNRAQDNAATPAEMAAYDLEIQTKLIIKEIQTVALRMEHLGDNRRPFLSVLATLVEKSMHIELCTEILSMVEGWVFRSEGTWPTLKEKTAVLHKMLSFEHRQDPTMLSRFLELVIRIYEDPKITRTELTVRMEHAFLIGTRAADVEMRNRFMAIFDKSLSKTASVRFTYVLTCQNWDTLADSYWLAQASHFMLGGIEPNTSIQLHSEDFRVTPLSELALMLPAKDRESREVGIMMDDKFEALMAGHRRFVAELGDVKVRDIIEPLTQLQHVDTPLAHQLWIAEFPLYWSATLRDDRFELERGIVSLLTRDYHSRQIDKRPNVIQSLVEGCVKTWPQCKLPPHVLKFEAKTYDVWYAAMVQLEQAAIKPETDSSMVRESNLDALVDLYASLEEEDLFYGTWRRRCQFVETNAGLSYEQSGMWDKAQKLYETAQVKARTGVIPFSQAEYMLWEDHWVLCAQKLQQWEILHDFAKHENFQDLLLECAWRNTDMWQEAQHRELLDNVIKGVMDAPTPRRAFFQAFMSLLKFHNQQETALDFARVCDEAIQLTIRKWHQLPERLTNAHIPLLQNFQQLVEMHDASVICQSLASTNAANLDVKSGELKLLLGAWRDRLPNVWDDITAWQDLVSWRQHIFSLINQTYLQLLPPQAQQNAGGANSFAYRGYHETAWIINRFAHVARKHSLPEVCISQLSRIYTLPNIEIQEAFLKLREQAKCHYENVEELSSGLDVINNTNLNYFNPQQKAEFYTLKGMFLEKLNQKDEADNAYGMALYFDIGAAKAWAEWGYFNDRRFKEEPSDLNAARQALTSYLQAAGSYKSAKSRKLLARILWLLSLDDAKGSIAMGFDDFKGETPVWYWITLIPQLLTGLGHKEAPRVYQILLSIAKSYPQALYFQLRTNREDMNLIRKNQEAKERARLLQLQQQSQQSQQQSKSPLQQTKQEHAEAEVKAEPPQGVVPQGVVPQGVEAGQEAAGQKKPPWELTEEIMSVLKTAFPLLALSMEAMVDQIQKHFKCPPDEDAYRLIVALLNDALTYVSRTPASFARSVKLPAATETNITRFAETILPNHIKKSFEKDFVEVKPTMYEYIHKLRRWRSKFEEKLDRRVAHAPLEAFSSHLSEFRYQKFDEVEIPGQYLQHKDKNQDFVQIERFLPNVDLVRSYSASYRRLKMRGHDGSVHSWAVQHPAARHCRREERILQLFRQLNQTLGRKKESRRRNLQFTLPVMVPLAPHIRIVAEDRSYVTLQAVFEDHCRRMGQAKDDPILYTLEKLRGVLDTDSPQAKLELTPPARLEVFNAVQEKWAPQTMALEYFQLIFPQFAEFWLFRRQFSYQLSALSFMTYILYMHNRFPSKMNIARGSGNIWGSELMSFMNSPKLLFANPEPVPFRLTPNLQVLMGPLALEGIFACAVMAIARCLTEPEDELDHALTLFVRDELIFWLMSSHRGAISESQLREQVQTNSDSIVKRAASLARNPSGNLPANQTVIDAVAKAVHPMNLAQCDALWMPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LN88</accession>
    <name>A0A367LN88_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_2718</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LN88"/>
    <dbReference type="STRING" id="1330021.A0A367LN88"/>
    <dbReference type="OrthoDB" id="2133190at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032933">
        <property type="term" value="P:SREBP signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11399">
        <property type="entry name" value="bHLHzip_scHMS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.280.10:FF:000116">
        <property type="entry name" value="Putative HLH transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052099">
        <property type="entry name" value="Regulatory_TF_Diverse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019006">
        <property type="entry name" value="Sre1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09427">
        <property type="entry name" value="DUF2014"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="7">
        <location>
            <begin position="198"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="21"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="310"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="364"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="262"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="317"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="383"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI15879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="957" mass="104808" checksum="BD690336D02EC653" modified="2018-11-07" version="1">MADDESASHFGLDSSVFGFMADGNPLSDANSDPPAASADNPQSFYDPSSWEFPVNPPFDSYDSGTPAASVAPSWPLPTFDQRQQPQSQASPSFDSFATPRLNPRTVFGSNPSASTKGAPVRAPPPMSNEELRNIAMPPHLHYNSPKSASSPDSANSEAKAGAASSPDLPGPFKKDSRKRKAFDELEDDDEVDDGEKPVKKTAHNMIEKRYRTNINDKIAALRDSVPSLRIMSKSARGEDTTEDREELHGLTPAHKLNKATVLSKATEYIRHLEKRNSRLSDENVAMRERIEAFEKLFMAGAMNGSIGPMQQPPTPMAFSQENQQQFASSPMATAQDSDSNPPGMMHVPEDMKRIISAQMTVNQPYPVPQQPIRGGDPTVVRHQQIQQQQQQQQQQQQQLRRNGWVNVGPYFGKLMVGSLAGLMVIEAIREEERSIEDPKGRGLFALPLQAIDRLSSSALDLHVLGCHVHTSLKLVLIVGACLWTFVPWLLKWPEPRPEKRQAIALRRAPSLASPIDVRRQAWLTAVQTVWVPRHNFFLEALALILKAFKLSLRNAIGVHAYQMLTGLSEEEEASRVKAWSIALDSQLAGGDVGICNSRLILTLLASGTLPDSPALLMLKALHIRLLLWQISKSNRLLGAVNAVAAKLARKRWNEARQLNRLLVRLRRGSRAAHEHELPDHLFALVEQESDDVLSASVIQRAHNLAFNVNTASSVESRIDGMDAVVDDVAVGSPMDAVAAWWSTQLLHRVLTATLDEDTQALRGRAEDIGLAIKVAPAESVARIRAVLARAVLVDGSCPEDANLARQVMAKGKADGPLGRPVAGAPPDGDLTMSLKCATAIAQFRRAPNAVGRLDVLEGIAKLEHMSSMTLLGFTAMMELMKHLLGQEGPRHEFDVTMSRLLSGLRIWMGRPSATRCGVSLELRNKLVERCLAATKSLALPDKEVGYGSLSDGQEMDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNN0</accession>
    <name>A0A367LNN0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 9">Imidazoleglycerol-phosphate dehydratase</fullName>
            <ecNumber evidence="4 9">4.2.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_2070</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:11040"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="EC" id="4.2.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 6/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the imidazoleglycerol-phosphate dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.19" evidence="4 9"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNN0"/>
    <dbReference type="STRING" id="1330021.A0A367LNN0"/>
    <dbReference type="OrthoDB" id="447729at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00011"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004424">
        <property type="term" value="F:imidazoleglycerol-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07914">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.40:FF:000005">
        <property type="entry name" value="Imidazoleglycerol-phosphate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.40:FF:000001">
        <property type="entry name" value="Imidazoleglycerol-phosphate dehydratase HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.40">
        <property type="entry name" value="Imidazole glycerol phosphate dehydratase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00076">
        <property type="entry name" value="HisB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038494">
        <property type="entry name" value="IGPD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000807">
        <property type="entry name" value="ImidazoleglycerolP_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020565">
        <property type="entry name" value="ImidazoleglycerP_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133:SF2">
        <property type="entry name" value="IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23133">
        <property type="entry name" value="IMIDAZOLEGLYCEROL-PHOSPHATE DEHYDRATASE HIS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00475">
        <property type="entry name" value="IGPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00954">
        <property type="entry name" value="IGP_DEHYDRATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00955">
        <property type="entry name" value="IGP_DEHYDRATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI16054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="233" mass="24815" checksum="F8EA33256D00C49B" modified="2018-11-07" version="1">MSSSSDKRARAAALARETNETKIQLALNLDGGQFPPDTPRELLQSCGGGGEGHASQASPSQLIAVDTGIGFLDHMLHALAKHAGWSLAIKCRGDLHIDDHHTAEDCCIALGSVFNKALGTPSGLARFGYGYAPLDEALSRAVVDLSNRPYCVVDLGLKREWLGKLSCEMVPHCLQSFAQAARVTMHVDCLRGENDHHRAESAFKALAVAMRMATSRVPGKEGEVPSTKGTLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LP00</accession>
    <name>A0A367LP00_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fungal lipase-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_1814</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LP00"/>
    <dbReference type="STRING" id="1330021.A0A367LP00"/>
    <dbReference type="OrthoDB" id="438440at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46023:SF6">
        <property type="entry name" value="LIPASE CLASS 3 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46023">
        <property type="entry name" value="LIPASE CLASS 3 PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="2">
        <location>
            <begin position="225"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI16158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="472" mass="51071" checksum="E41F971580E02D4A" modified="2018-11-07" version="1">MGFFSSRKGHKSSHSFTDPPNVYFTPAPPMRLPTAPLPVLNDPFPNINRPWTTTPTLEPPQHPPSPWLHPAAVAPEDDMMLQRFDRVLEYEQYTGQDADDLFLCQPAPDLATTTTGQRDLPRAAERKRPHDTRLLPPASVVPVRYLAKVQLYINSKLPMALPPLTLDTTIWPLICLAAQCSLRVYSPPSSALERRQSVLVPADRRSGSKAMYIRSVPADAAGTVVLAVRGTASLADWFVNLRSEPTEPTSFLDDAGNACHAGFLSAARAMIRPAADRLRLILSQDPARASHSLVLTGHSAGGAVAALLYMHMLADGAASELSHLASCFRRVHCVTFGAPPVSLLPLVNPSSGIFLSFVNEGDPVARADKAYVKSLLALLASPPPPLPPPPQYPTPTFWPVPPSTLSNAGHIVVLRGDVSAVDGRRVEAVEAVTCREDQLRGVIWGDPVCHWMSVYAARVETLAAHAVAVEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPM5</accession>
    <name>A0A367LPM5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phosphatidyl-N-methylethanolamine N-methyltransferase</fullName>
            <ecNumber evidence="14">2.1.1.71</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Phospholipid methyltransferase</fullName>
            <shortName evidence="14">PLMT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L249_2740</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the second two steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylmonomethylethanolamine (PMME) to phosphatidyldimethylethanolamine (PDME) and of PDME to phosphatidylcholine (PC).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phosphocholine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32739"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32735"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
            <dbReference type="ChEBI" id="CHEBI:64573"/>
            <dbReference type="EC" id="2.1.1.71"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 14">Phospholipid metabolism; phosphatidylcholine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Endoplasmic reticulum membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Mitochondrion membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.71" evidence="14"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPM5"/>
    <dbReference type="STRING" id="1330021.A0A367LPM5"/>
    <dbReference type="OrthoDB" id="8300106at2759"/>
    <dbReference type="UniPathway" id="UPA00753"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000773">
        <property type="term" value="F:phosphatidyl-N-methylethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03216">
        <property type="entry name" value="PLMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024960">
        <property type="entry name" value="PEMT/MFAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15458">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15458:SF5">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51599">
        <property type="entry name" value="SAM_PEMT_PEM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11 14 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12 14" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="13 14" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="topological domain" description="Lumenal" evidence="14">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="intramembrane region" description="Helical" evidence="14">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="14">
        <location>
            <begin position="137"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="14">
        <location>
            <begin position="185"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="14">
        <location>
            <begin position="249"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="168"/>
            <end position="170"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="250"/>
            <end position="251"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCI16360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="276" mass="30525" checksum="0AC82D1442D45765" modified="2018-11-07" version="1">MDAIPSGSRRRHVSASLLANAISSFDYTTNLAEISHPLNTAYMAPLVDFEKQSLLVSACSIAFNPLFWNIVARQGFPNLLSLLPFPIRCDKTNTRKPNKKNKIKEYHHKLLTNLFGGNSRRACYALAATIFSLGLLRDWLYKSAIQEQPSHPILLTPFSRLAAFILLASGNILVLSSTWALGITGTFLGDYFGILMDRIVTGFPFNVCGAPMYWGSTMSFLGTALLLGKPAGILITAWVYFVYCLALRYEDPFTAAIYAKRDRERAASGGAVKKQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQ76</accession>
    <name>A0A367LQ76_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_2601</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQ76"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI16392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="97" mass="10709" checksum="994E66151CFD6529" modified="2018-11-07" version="1">MGPGTRRDIKKTPETGRRLALSARGWPCLGFSFLPPWASRERGWVWSCTGAEEVQLAGESIIRAELVLCATNCYPSIHSSSFVILSSPFRPRTVSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQA4</accession>
    <name>A0A367LQA4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Spindle pole body-associated protein cut12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_2008</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the UreF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQA4"/>
    <dbReference type="STRING" id="1330021.A0A367LQA4"/>
    <dbReference type="OrthoDB" id="5383703at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4190.10">
        <property type="entry name" value="Urease accessory protein UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021589">
        <property type="entry name" value="Cut12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002639">
        <property type="entry name" value="UreF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038277">
        <property type="entry name" value="UreF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33620">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33620:SF1">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11500">
        <property type="entry name" value="Cut12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01730">
        <property type="entry name" value="UreF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spindle pole body-associated protein cut12" evidence="6">
        <location>
            <begin position="119"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="44"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="263"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="324"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="398"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="574"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="263"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="351"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="411"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="456"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="491"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI16589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="850" mass="93067" checksum="AA6568B9826735D9" modified="2018-11-07" version="1">MLGWMLRGSENADSQGASTDATNAELPDTPAPVFAARALKSALFGTPAIPDDSPLTKKEARESRRAMAGTDKGSSGTPSKPPGILLTPGTGTSRRKRVSFGHHVGDTEPTTGKPPTEATSPSKGVDDSEADWEEEDDDDGFCTHDVTLDLNEPHSQSGRYWKGQFERYHQEAKAEMEKLLKYKQLAKSYARQKDAEAVRLAERLREERQRVIHMEKKIADNASKIVSRRDHSDDREPGELLAKLTKQTSLAAEYRQRVHELESELDDVMRQKDQQQGAEAGSRRRRVVTAASPTTQKTLVETQRELRRARVQLRELDALRQEMSALKRTQTKTTSLRDKKDQSSLKLQLDQSREETRKRSEELDQLKSDFEAFRRASEAYEADSRAVLERAQGKVSDLKREMRALKASRRPSPDDNRRRKNTRDSIEGALTERTNAEKPTTKWQPFIARSPRARASRSSQDSAAADDAREGAAQLPADSKQRGGGGGALPPERRAAALARIESRMEERRRVTRTHDKENRRPQSHAGAWLGVVCGVTGIFFNPPPNQHPPPLQTVCLSVFLSLSPEAMAASDGDDANEDDLKTLQAEVTNLEAQLASAPEADTTHSLLLLADSALPIGCFAFSSGLESFLAHGSQPDSNLRPFLGLTLSSTASTSLPFFLAAHGDPEKLLSLDDELDASILCPVARRASLAQGRALLAVWDRSLGHHMSFGGAGSLCALRQFAALLRAAAAAAAASTADDDDDHVPPQPSAHLAPLFGAVCAVAGLAGRQAAYVFLLGHARAVVSAAVRAGVVGPYQAQRVLAADQLRRFIDALIEREWQTPVECAGQSVPVMDLWIGRHELLYSRIFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQC3</accession>
    <name>A0A367LQC3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQC3"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="403" mass="44882" checksum="5759B32B03A662FE" modified="2018-11-07" version="1">MKGGREARRNGIRSWRQDDDEGVSGSYQVACLGHGLGGDLSLWSDMGPCRVNVWVQGVSVGGRRAGIVIALEVSMGPVRVITTVHQPPLLRATGYRLQRLQATGYYTPGPTTVLLGGRQELERVAKLSMGASFLPFLASLTVLPRLPRTEDQALPTTSAHIKTHDSRALDITSRYVSHRRNGIRLGENSPCSSCLCLDLRRIEDATTANSFLKSSTPQQTLAIAEIDMTSNYGCHRLCDGSPCHIQDMWLSNQSSMAVTSHDIKLVPERDRFPCLTKNRNPLDREEGARERWRGGWTELRHGHRHRLFSTVGKAFCFSSHDTSVHKPLGRGMRRNSPLPAGAVVIGGVRFVCATKRWKKKKKKKKKCIQNFTLHTRRIVPSWIAGSDDEGREWGRVTPESDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQK5</accession>
    <name>A0A367LQK5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQK5"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="405" mass="45835" checksum="6ED021390D844101" modified="2018-11-07" version="1" fragment="single">MYSVHTSAFSTLQINKYDDGYIAEKQFQTHTNRILLVFASRDSRRIYFPPEISKSCLKTKHVADGCTVPPYWLMLRRKASPHTTRPGHLVTSSKLANPQRLGSVLLDDPDKRKRENDELRLFRPLPPRGVLFDTSFHFFAAWAEDRFPTDHLDARAQREEAQDFRIGPFWPSLHARQAHWHHETRLVPLPEPTVVPGMRDPRGPFFFLSFGDTRRAPPSLSPLGRPGAEVRESNCKKKRVPKDRESRAGSTQKTGREMDQVCLQRPRVSFCLLAESRPLMSRDCDSVFSEFRVAPPPPPSPTPASGDVPRPRMSAFWRRKEAQSRVEGGADNKQFFFFIVSPPAGLQKQFQRVSSETKYLPSPSAPAFSLQLPDGQRNATLQPLLPEAADAVTLQVAGKTVRSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQT4</accession>
    <name>A0A367LQT4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA2/NAM7 helicase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_1721</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQT4"/>
    <dbReference type="STRING" id="1330021.A0A367LQT4"/>
    <dbReference type="OrthoDB" id="409395at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057373">
        <property type="entry name" value="ZNFX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF341">
        <property type="entry name" value="NFX1-TYPE ZINC FINGER-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25396">
        <property type="entry name" value="ZNFX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0347">Helicase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ZNFX1" evidence="5">
        <location>
            <begin position="72"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="3">
        <location>
            <begin position="245"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="3">
        <location>
            <begin position="547"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="4">
        <location>
            <begin position="634"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="898"/>
            <end position="1170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="929"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="962"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="989"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1019"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1145"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1160"/>
            <end position="1170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI16824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1170" mass="132231" checksum="1C64FC3507D26F64" modified="2018-11-07" version="1">MHADWRELREVPRPEEFMAPIPPVLPRLHPILTGSKEDFLRAHYLLHRYEATEVLRRAVNAYRHNPQLVDTRTVKMYRGVLARAYVVSPLRIACRLAFSAPRNEMEAGLDKPEDITSGSLVVLSTHEDGFRTKCFVGTVAPIPEDPEDAKDAGTPSDQSVIDLLWADPSDVVLDPNQKLIMLEPKTGYFESIRHTMTALQRSILLEHNIDRYLYNDSDDMKAKRARYIKETPSNAVVYPDRVNDLDASQFKALQMASNDELAVIQGPPGTGKTYTSIVAIETVLKTLGICHANRISGGDTYDAPIIVAAQTNHAVDQILLKCVDLGIGRIGRLGGRSDNETIQEVTLYNLRKRHVPIAGGIPQRRKATRYQAEIRKIMTDFGVLKADQLREFDVLNELQYKSLIKDDEWETAETDSGAENEQPLPMHRWLDEYMQQPEFRRAEQFTAREGDLHPSLRRKLRGQRFHRMEMNHLESIIRAMHCDEGGTWYDRAARLLANTNNLYHIKPADRGAVYCYLYKRLSVQLRLKFGEIIEDHATNSKDLQWTRRQDDLMAMRREGVKILGCTTTGLLKHWDLFSLLSPRVLLIEEAAETREANIVAALTPSIEQLILVGDHQQLTPRADLQELCLWPTRLDYSLFERLVSKRYPYCSLQVQRRMIPELREVVQTFYPALKDHESVTSPERQKPIPGMQGCSLWWFDHTWPQHRGASGYAFSNPKEARMIIEFTKYLVKNGVRPVDISILTYYSGQRELIKTELARESSLRCSDPEFEWSVRTIDDFQGEENEIIILSLVRGPDMDGQRAKPGFVANENRAVVANSRARQGFYIFGNSQNLIGASRQNVWREIHRAFGRRTGTYMPVICAPHGTEINVMEPSDWDKVSRSGCSLLCRGRPLLPQAGKPLEKSTAKKKAALPKTSKQVGIKQVGMKSPQTMSLQRSPPSSREASVTRKSDEDVVGQAMTSSQFSSQFWSGSKTQVLKRASVESLRGSSQTTSKTATQTPNGTGMKSEQRSRQISRQRSPERSPQRSPERSPERSPERSPQRSPASSRRKSTAWKLTPTHASTAQKPKQAGMKSPQKSPPGSRGASAPQKLNDRMTSSQFASQLLGGLPKAPGRRPTRYTSDQILERGMRNMFTVRDTSRGASERAMSTTSAEATATSHDSDGDDLIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LR52</accession>
    <name>A0A367LR52_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3051</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LR52"/>
    <dbReference type="OrthoDB" id="4928221at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35711:SF1">
        <property type="entry name" value="ECTODERMAL, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35711">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="545"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="581"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="591" mass="62648" checksum="D7DF60DDC959E8CC" modified="2018-11-07" version="1">MTDVSDSLGGTVGYTPALDLDLNSTSPRTFPSPWPHLSLSFTTAAPSPHQPNVVPHLTFTSFLSRTQLINLSLLFSFESRSPHSHQSPSAPHALIPPSLPPYHPPPLQPSPYAAALAQGSSHNHVPLSFSLSLACSASSKRQVEFFPSTKTDSDKSHGNSRPTTPPPPPPPPPPPLPKSNPHLSHHHPNPHQQKKKNTLLSASTITKAGQTATNMMNRLFPLAILAVSPMVDGRIARLQPRQSLDTSYANQNLEPASPSHQSITPILKNKPENVTPNNNKDAGSYSLPPPQSYRSPRRPAASSLPSNAPSGSAMYGAEDPSDENGATSYYGMQQTEEEEEEEEEYEEEEEDDDDDDDDDDDDDDDDDDDDDDDDDDDQGYDHAQNTPSAPASTPVPHPDYASPPTSPTKATNIPSVPLGRKQRPSRMSANTALPSGPKPNTPSGAATPTVLTVTVIPTPSGDTKHSDHAPTVVTVTAVPPKSAPSKGAGSPPVLTVTVVPTKSSQQPYDDVSAATPATTPTVITVTAVPSQADDSTGPMDTEYGSSSSTSCTTTSVSTTTDDGSRPASTGSKKPLPYIKGMPREHLSDYGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRB4</accession>
    <name>A0A367LRB4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">SP-RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_2697</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NSE2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRB4"/>
    <dbReference type="STRING" id="1330021.A0A367LRB4"/>
    <dbReference type="OrthoDB" id="26899at2759"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16651">
        <property type="entry name" value="SPL-RING_NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026846">
        <property type="entry name" value="Nse2(Mms21)"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21330">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21330:SF1">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11789">
        <property type="entry name" value="zf-Nse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SP-RING-type" evidence="13">
        <location>
            <begin position="280"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="142"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="231"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="64"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="160"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="251"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI16959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="380" mass="43527" checksum="44249C8E75973359" modified="2018-11-07" version="1">MPRLVNRGNAYAATTTSTLPPYEPPSCEPDEEAGRKLSDLANNRGHSLYEAQVKECLRHLNLSVRDLNERLYDQRDRLTSLQSRRTQKGTDISEEEDRLRQHLDTFQHEVDHLTRQSEAAVRDCIDRRAELEDEATILEQLASRSISTATSSSSTQPAHEDDDDEDQDQDEDAERKKPPKSAAPSILKAFRQARSTKLTEYENKLSAHQRYALQNDYIAFKKSWHDAVAGEGGPPLPDASKWFRPDGQPVMDRRPRSDAARRRSGPDIDDDVHGEDEDDDDDEIAVAREVISINCPLTLRPMVEPYSNNKCKHTFERSAIVDYLSSQRELQCPQTGCSAMFSRDTFHQDFHLDEAILRRIQREKETHRNRALDDDDIEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRI7</accession>
    <name>A0A367LRI7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Alpha-amylase</fullName>
            <ecNumber evidence="4 16">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">L249_1793</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="4 16"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRI7"/>
    <dbReference type="STRING" id="1330021.A0A367LRI7"/>
    <dbReference type="OrthoDB" id="204980at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11319">
        <property type="entry name" value="AmyAc_euk_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000120">
        <property type="entry name" value="Alpha-amylase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013777">
        <property type="entry name" value="A-amylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006046">
        <property type="entry name" value="Alpha_amylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF212">
        <property type="entry name" value="ALPHA-AMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001024">
        <property type="entry name" value="Alph-amyl_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00110">
        <property type="entry name" value="ALPHAAMYLASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 16" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 16" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016652885" description="Alpha-amylase" evidence="17">
        <location>
            <begin position="18"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="18">
        <location>
            <begin position="30"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="11">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="46"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RCI17064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="466" mass="51993" checksum="C28410C18990B64B" modified="2018-11-07" version="1">MKASFLLACVPVAVVLAADATAWKSRSIYFALTDRFSKNNSETSPCYDLGNYCGGTFRGLESKLDYIKELGFDAIWISPVIKNLSIDHDGGYHGYWSQDLYSINPNFGTADDLKSLVDAAHSKVGMFVMADVVANHMGSPIDMNRPEPLNKAESYHYPCIINYADQGSVEYCQIGGLPDLNTQSPRVRRLLYDWIHWLVDEYRFDGLRVDTAKHVEKEFWPGFSSAAGVFTIGEAFDHRPGFLAAYTGGVMSSVLNYAVFHPLNNFYMQLGSSQALVDTHDAVSYAFSDPTVLGTFIDNHDVPRWLSRKKDDSLLKNVLTYVLLARGIPILYYGTEQGYAGGDEPWNRESLWHTGFNRQSDLYRFISKVSAIRKAAGGMPDNDHVHLMVEDTGYAWGRAGGNVIALTSNIGSGNSREYCVLTRRPHGVWRDAFCDREYVADDRGYMCALVTNGEPIILVAVDDHRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRP0</accession>
    <name>A0A367LRP0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1783-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRP0"/>
    <dbReference type="OrthoDB" id="2100652at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014807">
        <property type="entry name" value="Coa1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042432">
        <property type="entry name" value="Coa1_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28523">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28523:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08695">
        <property type="entry name" value="Coa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI17081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="233" mass="25939" checksum="4E53293938ED1209" modified="2018-11-07" version="1">MLMRMAWRGTSKMTTTTTTTTTTVSLSRRWMMVAAPKKGDGPLMTRRADRMLPELAQIRTRTWRRTLPLFALTMALSSIAIFNYQKTSSPVVSAVLYALRTSPLARDLLGNDIYFRRAMPWISGELNQLHGRVDISFAVKGDKSHGLVRFVARRETPGAPFVTHLWSLAVAADGGRGEKKMRGEDGVVDLLREARADPFADLLKGHDDGDDDDEVGVGEVAETRGFRQGRMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRV4</accession>
    <name>A0A367LRV4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRV4"/>
    <dbReference type="STRING" id="1330021.A0A367LRV4"/>
    <dbReference type="OrthoDB" id="5239281at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI17148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="18046" checksum="B955F910E6970D71" modified="2018-11-07" version="1">MPPKKTPSTDEDDTVNALTTTELRFIKAVFDNMTQKPDANWDNVARDLKLKNAKCAKERFRQMSVRHGWREQQQPSTPRKEKPSSASASVSAEGRVQKIRTPRKKSVMREEEVVKDEESDEDNGVKTDADVIDEDGMQTDFDTIGGDGMRTDAEAVDDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRV6</accession>
    <name>A0A367LRV6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cofilin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Actin-depolymerizing factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_2365</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the actin-binding proteins ADF family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRV6"/>
    <dbReference type="STRING" id="1330021.A0A367LRV6"/>
    <dbReference type="OrthoDB" id="1733909at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11286">
        <property type="entry name" value="ADF_cofilin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000001">
        <property type="entry name" value="60 kDa chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000001">
        <property type="entry name" value="60 kDa chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017904">
        <property type="entry name" value="ADF/Cofilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000592">
        <property type="entry name" value="PRK00013.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009487">
        <property type="entry name" value="PRK12849.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009488">
        <property type="entry name" value="PRK12850.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009489">
        <property type="entry name" value="PRK12851.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45633">
        <property type="entry name" value="60 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="11">
        <location>
            <begin position="584"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI17149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="733" mass="78002" checksum="451E102F37C7847D" modified="2018-11-07" version="1">MQRALGSRARATALSSGASLRYRSAAGLGPQLRFAHKELKFGVDGRASLLSGVDTLAKAVATTLGPKGRNVLIESSFGSPKITKDGVTVAKAISLKDKFENLGAQLLQDVASKTNEVAGDGTTTATVLAYAIFSEMVKNVAAGCNPMDLRRGVQAAVDAVVDYLQKNKRDITTSGEIAQVATISANGDSHVGKMIANAMEKVTKEGVITVKEGKTMQDELEVTEGMRFDRGYVSPYFITDTKAQKVEFENPLILLSEKKISAVQDIIPALEASTQMRRPLVIIAEDIEGEALAVCILNKLRGQLQVAVVKAPGFGDNRKSILGDIAVLTKGTVFTDELDIKLDKATPDMLGSTGSITITKEDTIILNGEGSKDAIAQRCEQIRGVKDDPSTSEYEKEKLQERLAKLLGGVAVIKVGGSSEVEVGEKKDRFVDALNATRAAVEEGILPGGGTALLKASSQALGSVKTANFDQQLGVTIVKNAILRPARTIVENAGLEGSVVVGKLTDEHGTDFNKGFDSAQAKYVDMIEAGILDPLKVVRTGLIDASSVASLLGTTEVAIVEAPEDKPAGPPMGGMGGMGGMGGMIATVSQECISAYNDLKLSKKYKYVIYKLSDDNKQIVVEEASDNKDWEAFREKLINATCKTKTGNVCKGPRYAVYDFEYSLAAGDGVRNKITFIAWSPDDAGIQHKMIYASSKEALKRALTGIATELQANDQDDIEYDTIIKTVSKGLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LS53</accession>
    <name>A0A367LS53_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LS53"/>
    <dbReference type="OrthoDB" id="4964810at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI17239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="101" mass="11054" checksum="0C375FEC1CEA5810" modified="2018-11-07" version="1">MPAYEYCCQCGGMIVISTTCTACGHKQCQHNEKQKGGEKNLLRSTTQHAIHPIVGAITPLTTTYYHHLRIPPPTAPSQTQPIPPPTLSNSLQFPGHHPRSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LS61</accession>
    <name>A0A367LS61_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_2281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LS61"/>
    <dbReference type="STRING" id="1330021.A0A367LS61"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI17283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="138" mass="15862" checksum="BCE6C92113B07E9C" modified="2018-11-07" version="1" fragment="single">TRYKDIRTFSRKKGEFSAFLTNLKDKIRTDKATFRDKEDRIGFLFRSLEGKACKTLETRYDSIERPFSGLAEIIYLLTKTKDDSLSYEDFCGYVKDSAVKRLDAELVLPNDLPALAKYSLSILLPKTPLLNRQIDPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LSL8</accession>
    <name>A0A367LSL8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Lariat debranching enzyme C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_2443</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LSL8"/>
    <dbReference type="STRING" id="1330021.A0A367LSL8"/>
    <dbReference type="OrthoDB" id="407609at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008419">
        <property type="term" value="F:RNA lariat debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00844">
        <property type="entry name" value="MPP_Dbr1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.980">
        <property type="entry name" value="Serine carboxypeptidase S28, SKS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007708">
        <property type="entry name" value="DBR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041816">
        <property type="entry name" value="Dbr1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042269">
        <property type="entry name" value="Ser_carbopepase_S28_SKS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849:SF0">
        <property type="entry name" value="LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849">
        <property type="entry name" value="RNA LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05011">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01124">
        <property type="entry name" value="DBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Lariat debranching enzyme C-terminal" evidence="12">
        <location>
            <begin position="791"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="723"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="766"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="941"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="734"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="941"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="967"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="1035"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="1040"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="1117"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="1122"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI17232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1172" mass="131727" checksum="60DED43C7FE059BD" modified="2018-11-07" version="1">MMRHGDQPKWWQRYGIVKDHFKPHGPIILQVVQEDVEQVWEKSLAYTYAKELRGTAVFLEHRYFGPSLPYGPRSNETQALAALTLDDVLADAKTLIEMLRKTDLDHRWSPVIVTGSGYEGFIAMALRQMYPDFFFAAIARAPPNLSLNLNPAASNAEQYLYRNAVAAAWRRRSPYAASQITKVIDWVGHQVNGQPHMLESLQKLLGLCTKPRLGSKEDTRMLQRFVEGSFILASLADNPYTGGNNAGVMAGVVNELMHMEEHPVTGYGHFLRWLDDRVLSGRPNGLDLNCIPWAGLNNSQVTDERVSRAWRTMRYIGCTYYPLCTANAEAGGIFRPQTQGCLEEQRECFAEFEGYAVPMKQNDIWRRYKLGPEDLAKSSRIILSVDKSDPVRSLLGAWPRGASWNSCNYSRRIEYDEKALDKNLVRPHVTLISDPRDQRSSEMPVRAACGVAAFIVYDFDDAAAFFVYDFNALSSTTSTSMSASTIVRGVRVAIEGCGHGTLNAIYASVAQSCKARGWDDGVDLVIIGGDFQAARNAADLSVMSVPAKYRQLGDFPDFYSGARVAPYLTVFIGGNHEASSHLWELYYGGWVAKNIYYLGAANVVRFGPLRIAALSGIWKGHDYRKPHHERLPFNQDDIKSFYHVDVGLSHDWPRAIEKDGDSEWLFRRKPDFRQESMDGRLGSVAAQYVMDRLRPAHWFSAHLHVKFAAIKKYGDKAIEAATPIKAASPSPEANPDEIDLDMDDGDGSEPAAQKTSQVPDELRAQLPASFAPPPPAPEAAAVRRINPGQPVPPGIINTEVRFLALDKCLPGRRFLQLCEIQPISQQQGEDRRRLQYDAEWLSICRLFHKSLTFGGDRNQPPAQYMSEEEYLPLLEAERAWVEEEVVKADKLEVPENFEVTAPPYVAGDPERVDEQPEEYTNPQTAAFCDLLGVENLWDGSAEERRQRRDRGPAPNQRAKNQFRPRAGKGGGGGGGGGGATSFQLRQYAEVTLGGGSLRKVVKLPEGEDENEWLAVNMVDFYNQINLLYGAITEFCSPQSCPEMKATDEFEYLWQDSENYKRPTKMAAPAYIEQLMAWVQSNIDNESILPSKIGVPFPKSFPTLVRQIFKRMYRVYAHIYCHHYPVIRELGLEPHLNTSFKQYVLFIDEHGLASGRDYWGPLGDLVDSMLRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LSM0</accession>
    <name>A0A367LSM0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_3130</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LSM0"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF15">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="51"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="178"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="479"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="721"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="854"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1127"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1474"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="561"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="673"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="931"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1038"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1168"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1235"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1389"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1556"/>
            <end position="1639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="881"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="899"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="920"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1474"/>
            <end position="1483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1491"/>
            <end position="1503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1504"/>
            <end position="1523"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="138"/>
            <end position="145"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI17350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1649" mass="181438" checksum="0001A73FA44A61A0" modified="2018-11-07" version="1">MAPSPPASPVHSPQRPLSAIARPPPRCPSRMSISSKPGSASRASDDDSRTAVRVAVRVRPPLKPTDPGYDLVPSRFQRSMVQITSDTSLAIDTPQGQKVFVFDRVFGPDVMQDGIWDYLADSVNAFTQGYNVSLLAYGQSGAGKSYTMGTSGPPEQLDPDMMGVVPRAAAALFEKLNQSRSGSNPGRISNSTTTSQLRTPRGYGPRGTTLGDRNWSLKATYVEIYNEQLRDLLVPDSTAAQERGNVAIREDAKGNIILTGLHQVEIDSVDDLMNALNFGSSIRQTDATAINAKSSRSHAVFSLNLIQRRSRLQPSGLAEKRFSVPLEAMTGQDVTVTTDSKLHFVDLAGSERLKNTGAQGERAKEGISINAGLASLGKVISQLSSRQPGSHVSYRDSKLTRLLQDSLGGNAITYMIACVTPAEFHLGETVNTVQYAQRARAIQSKPRIQQVDDGDKQAVIDRLRAEVSFLREQIRSASAGVNGSPRPRRVSGAVNDRPDRQNEREVELNNQLLDVQENYNALGRRHAMLIAEMAKARESESVGDNPADSATDRLNRSNSFAQAVEQVVLEYEKTIQTLEQSLSNTRATLSSTETSLLEKESKCAYAETINSQLQLRLQKVMDREASTENYLHDLEAKLDGHTNGEEKNTTIIIELRKEIARVRENEASCEDYISTLEERLAESDQDAELMQREIDRLEQVIERQRCLGKLDSLLHELDHLEESDSINGTPPRRKAADPSRGPSTPKAVERQVGSSRSQFKTDGIVDGEEEGPTAEDGAVGGGATTSPVQSRLAAEKLTNVTQELTHLRAEHETTVRDLSDLHSRYEEALQTLANLQDAVDEARFPPRVRDSVLSIRSDAQARPGIPASSERSPDTDVPRYSVSRSLSSELSSAVGSSATADTEATSEDGTATARPAPSTDDLRRRSEDGALKEEVARLRTLAGEKEAAEKELASKFAELESKHSEALDMVEELKTEISKARAVEASSPRQSTPIIRRKSSQNITVIDRAHRSFTSLRNIATDNFDGQPEVMQNFELNLNAAIHELHSRSERIQELEADVAAARKEMETKTTIISGLTRERSSLKSPIMDMSTVAALRVQLEKSEMQVFEMRQERQAREAELEAELERLRQPLQGPADRDPSPADGEPEEVAKLQTELSGWEARHKSALGSMQATEAELRRTVEQLEAQIVTLNTNLADSQVRATADGNEAAKELGRHQALVAELESKVAAYGDAARAHQETLEKLKADHAKQLSEVRAMEQKGYEEQVEVLMTEHADALHKLEAELFEARDQLEKTAAMVGAALGLDVSVETLPEQVETLAAAHQKLAEEQRRASEMQERLTELMVANESTGRDLEAAKSALSSMLEGADGTERPSSITDQVSAVQTRMSDLMTKNKKHSRLVEELEEQLASNFDAVQISNNRLSTLQTERNAQLEEAQAARAKLQAELHAIREEYSSLQAKYQEVVGSVEVNRSNSNSTIRKSPSHASLPSPPPAIPLPPLPSAARSGSPTSGGQTSPSSRTPVKDGASISQVTEDHEALVRSIEKKLYAERHLTHTLEEALTDLEKQSKKVKSECDAWRKRASELESEVKELKERPAEIPHDNRWSMHAVEEERKKRQAAEAARKILEDRMNTMNKAKKKKGSLNCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZ43</accession>
    <name>A0A367KZ43_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_4541</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000028">
        <property type="protein sequence ID" value="RCI07438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZ43"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI07438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="135" mass="14356" checksum="8B56C4520B2C525F" modified="2018-11-07" version="1">MRPYAAKMARRRGLARDLATLKGRGREGGGKGGPASAACGCVAVGDCESSHIPTEYSVGVVVSNMELVQVETLSRKGKERGGEKRELEKVYKKTLEDDGSGVATLVRDYLGTGASQAACIRLYPLAHCRQRVCGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZ54</accession>
    <name>A0A367KZ54_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_4529</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000028">
        <property type="protein sequence ID" value="RCI07459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZ54"/>
    <dbReference type="STRING" id="1330021.A0A367KZ54"/>
    <dbReference type="OrthoDB" id="2431938at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050562">
        <property type="entry name" value="FAD_mOase_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356:SF2">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47356">
        <property type="entry name" value="FAD-DEPENDENT MONOOXYGENASE ASQG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="8">
        <location>
            <begin position="11"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI07459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="463" mass="51019" checksum="D9BA3FC4A19E6B6D" modified="2018-11-07" version="1">MALLQMPKDDFKVLIVGGSIAGLTLAHCLEKLNISYEILEQGRDISPQVGASVGILPNGARVLDQLGIFDQVEEAIEPLTFARIRFPDGGCLTSQYPTVLRSRFGYPLSFLERQKLLEILYSRLDGKHLVHTSQRVVRIEDDGHRAIVHTVDGKEYTGDLVVGADGVHSIVRSEIWRHDVKGIVTDKEKSSLIIDYACVFGISTGVKGVAPGLQLSLLDHGLTIHVFNGKDGKAFWFVVIKTKRRYAYHERPLYTPEDGRKTCEGIASKRIDGHLTFGHLWERCQVSTMTPLEEGCFDTWYGGRMVCVGDAVRKVTPNIGQGANMAIEDVAAVANALWSQRDKTRRRLEMGSIVQAIRLNRTRGVCRQSEFLTRMQAHDGLLKSLLVRYALPALHDIPAGSSVVVLGGAQRLAFAPLPARASTQASTWTVARTLVDAFKPRPGVVMLLCVLGLVVRAGLVSYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZ73</accession>
    <name>A0A367KZ73_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Serine/threonine-protein kinase BUR1</fullName>
            <ecNumber evidence="4">2.7.11.22</ecNumber>
            <ecNumber evidence="3">2.7.11.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Serine/threonine-protein kinase bur1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">L249_4559</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="4"/>
    <dbReference type="EC" id="2.7.11.23" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000028">
        <property type="protein sequence ID" value="RCI07479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZ73"/>
    <dbReference type="STRING" id="1330021.A0A367KZ73"/>
    <dbReference type="OrthoDB" id="28397at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07866">
        <property type="entry name" value="STKc_BUR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000562">
        <property type="entry name" value="Serine/threonine-protein kinase bur1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000514">
        <property type="entry name" value="Serine/threonine-protein kinase BUR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF233">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="37"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="370"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="413"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="434"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="473"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="512"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00073250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RCI07479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="531" mass="60781" checksum="766D62E07F5BC56A" modified="2018-11-07" version="1">MEKPPENTPGGTSPRTFALNHLRPKNSFHGCSHITDYELQGKLGEGTFGEVHRARSRRTGALVALKKIIMHHEKDGFPITALREIKLLKLLSHPNILRLEDMAVEHPSRQSDKRKKPIMYMVTPYMDHDLSGLLDNPSVHFKEAQVKCYMKQLLKGLCYLHENHILHRDMKAANLLINNKGILQIADFGLARHYDGPTPRPERPMGEGRRDYTGLVVTRWYRPPELLLHLRQYTTAIDVWGVGCVFGEMLVGKPILAGENDAHQLELIWDLMGSPSEDNMPSWKQLPGGDHLSPRPRSGNIQNRFREFGSGAVALLRELLKLNWRNRINAVDALEHPYFKMAPLPMEPHEIPMYEESHELDRRKFHDRKAALPPAPKGGTVGVGPDANGATAGFNSGDGYGSRNGVNGARYRGGPDERRPAWQRDRGPPLVRPPQDRIANREEPDYRDRGAPRSRVPGRGPGPDVDTYIPAYCRDDGSRRGPDRPREERRRRNSNDRWNERERHPRSRSRSPVHDRERRDRDRGDRDPYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZ83</accession>
    <name>A0A367KZ83_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_4569</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000028">
        <property type="protein sequence ID" value="RCI07481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZ83"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI07481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="236" mass="26642" checksum="0E1EF4DD5AA26863" modified="2018-11-07" version="1">MFFFSHPPNSLINGPTPPWHEARSTKGEDFNGVDWPEHIPLGSPNRDGLREYGVDIRSRSQDEKKQDEFIFIWHDCDDTEHFPSPSMILRRPTQEIHRWGGGGGVETLMVRGVFFIRTSPYVSVNGLDFAAWPSIGGAKFCRQNAPSAWIWSVGSTYKFITYDRSMHPSPLGADLHDRPTGSLPFSFRTINRPTPAHCNTPCKPLTWEAAPSGLSMDDRLTLLKPQHPHTPLSLCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZ97</accession>
    <name>A0A367KZ97_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_4535</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000028">
        <property type="protein sequence ID" value="RCI07494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZ97"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI07494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="342" mass="37797" checksum="A74792AEA86031B4" modified="2018-11-07" version="1" fragment="single">MTLLRRSKFGRAGPTTAAPHHDICGAYVSGQRFTTSVTHSFYCSCPPITAITTTTTTTSATSTASTTTILQITPGSTLLPPRPLQFTEARQLQAAIQRKDTFVLLGRLAFASTLTRSLYTDAADCFFNFILHESTALIILPREDELLSYRPASHSKIMRSSSISPAEQTHPWLVALAGAWRAKILLFPPRFLKAPLAEMILDHLQPPRTEGKGTSSTVVLLEALAGHAHDMILDHLQPLQKKGERYFCNLFGQSKAHDMILDHLQPPQPQGRQMLTCHPRAPRSRLGQSRAHDMILDHLQPLRNPAPVTFSGKAHDMIPNHLHPLVAKGKGIISNHSWLRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZL3</accession>
    <name>A0A367KZL3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_1651</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNAP-25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000026">
        <property type="protein sequence ID" value="RCI07610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZL3"/>
    <dbReference type="STRING" id="1330021.A0A367KZL3"/>
    <dbReference type="OrthoDB" id="18679at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15857">
        <property type="entry name" value="SNARE_SEC9C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15886">
        <property type="entry name" value="SNARE_SEC9N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305">
        <property type="entry name" value="SYNAPTOSOMAL ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305:SF9">
        <property type="entry name" value="SYNAPTOSOMAL-ASSOCIATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="4">
        <location>
            <begin position="345"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="271"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="134"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="161"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="305"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI07610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="408" mass="44703" checksum="C8DDD81BBEFEEDBD" modified="2018-11-07" version="1">MKKFGFSKKGDDADDSDRSALFGRKKAADAQTSDNPYAQTGTNEAYVDASPSGNMTPYRQARSGLPAGPGRANAGLQASSRGGGYGNQPNSAGYGGSRDDSDGAYGSNRYNQGPGNRGPSGYGGFGRAYDNSSDDNRDALFSGARERVAQRPTASSYGEPGSTGGSYGGYGEQRELTEEEQEEADYQAILAEKRQIQQESASSVSRSVQMARQATEVGQATLARLGAQGERLHNTEKNLDLAANQNKVAQDRAAELKTLNRSMFAVHVSNPFTSKQRQQRADDQVMSRHRTERDQREATRREGYQASQRMESTFSELDAARSKARPQARKKDYGKFNLDDEEGADELEDQIDDGLDELQTHVSMMNIVGRAINKEVDSQNKQIDRIMNKSDAVDDATRMNRERLARIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L065</accession>
    <name>A0A367L065_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000023">
        <property type="protein sequence ID" value="RCI07820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L065"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI07820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="90" mass="9555" checksum="0EC598E06A6FB758" modified="2018-11-07" version="1">MRCRDGKNRLVAGCCCGASFTHCLFSQITSTIRRRRTFLIRTLGCWLVPTIPATAVHGAAATCLAGLSAPADPPSTLRKRPTQAPTPATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0M8</accession>
    <name>A0A367L0M8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="3 11">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_5722</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9 10">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="3 11"/>
    <dbReference type="EMBL" id="LKCN02000024">
        <property type="protein sequence ID" value="RCI07772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0M8"/>
    <dbReference type="STRING" id="1330021.A0A367L0M8"/>
    <dbReference type="OrthoDB" id="2162449at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04413">
        <property type="entry name" value="NDPk_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.141:FF:000002">
        <property type="entry name" value="Nucleoside diphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001908">
        <property type="entry name" value="PRK00668.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11349">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="12">
        <location>
            <begin position="6"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="9">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI07772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="178" mass="19949" checksum="C71D597717810DBD" modified="2018-11-07" version="1">MSGNINERTFIAVKPDGVRRGLVGEIISRFENRGFKLVAMKMTQPSKEHMQKHYEDLSSKPFFNDLVNFMSSGPVCAMVWEGLDVVKTGRTMLGATDPLASAPGTIRGDYAIHMSRNVCHGSDSVESAKKEMKLWFKGESIINYSYPDKDWLYDPKDGRIKSEIKEPALSETIPVDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L126</accession>
    <name>A0A367L126_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_6314</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L126"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI08128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="52" mass="5198" checksum="07436B0D2AB4AAC4" modified="2018-11-07" version="1" fragment="single">GGQHLDIHGRAAPGIQGFKWKYTGLVDDEPDASLEAKAGAAVPGLPGVQSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1N7</accession>
    <name>A0A367L1N7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_8807</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1N7"/>
    <dbReference type="STRING" id="1330021.A0A367L1N7"/>
    <dbReference type="OrthoDB" id="3231004at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI08326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="379" mass="43532" checksum="BE36FFDB9176A069" modified="2018-11-07" version="1" fragment="single">FDKSVASFLVRVNVQKQPPFQRNDYSFNVGKIARLDPSTHYKSLGDRWTVRFIEGGAFYARVSVVTNQDGNDHDVEAAAKAVFNGWGLDTALSTEAKQNLQRLREKATIEIHKMSLGELGLASESVVAQEEEDFTSIVEKLKREADEFYHQAHVHNKLLYAVLGEYDVLDAFSDREVHKPDYEPHTEPARLALDHFTQWKSLERKVARSEPLVTLHMWHPFKNQKLTEISHSAQKIIEWVRFEKSDGTKRNSLTASLPFQVSHVAREWNNDLPIPAEDPGQFRNELDKVFDPEPKAVLDLQTFRKQAKGIGFILDKIYIAQRDGTRDERAEAILPQLTTDLRRFLSDHERHFLDTGHGYIPLDRIENKYGVDRATGRSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1W9</accession>
    <name>A0A367L1W9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Deacetylase sirtuin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_8771</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1W9"/>
    <dbReference type="STRING" id="1330021.A0A367L1W9"/>
    <dbReference type="OrthoDB" id="424302at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47651:SF17">
        <property type="entry name" value="DEACETYLASE SIRTUIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47651">
        <property type="entry name" value="NAD-DEPENDENT HISTONE DEACETYLASE HST4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="6">
        <location>
            <begin position="24"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="383"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI08408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="393" mass="42269" checksum="E5E631C8EE92F5F7" modified="2018-11-07" version="1">MGKPLIRIPYTDILASPTVIPASARSLAGAVDALVAFFTAPPPPGLPPAAVVLSGAGLSVASGLADYRGVNGTYRLNKTYRPIYCAEFLASHEARKRYWARSFLGWSGLQAAEPNAGHHAIGQLGDLGLIRSVITQNVDSLHRRAHPDLPSLELHGYLRATVCTSCRAEYSRARFQEHLARLNPRWADLLRNALASGALATENLAERKARGLRFNPDGDVDLPEAPYTTFRYPPCPRCLADPPVGTDGRAHAVCVDYEGAWLPSSTAGILKPAVVMFGENIVPPVKRAAEDAIDGAGKLLVLGTSLATYSAWRLARRAKERHMPVAIVNMGGVRGESQFFDNLDPTQSGEQAARIELPIDQVLPALVSALRHGAAPASSADQPRQHVFKDMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L227</accession>
    <name>A0A367L227_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_8836</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L227"/>
    <dbReference type="STRING" id="1330021.A0A367L227"/>
    <dbReference type="OrthoDB" id="295274at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000053">
        <property type="entry name" value="BZIP transcription factor AtfA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051027">
        <property type="entry name" value="bZIP_transcription_factors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002112">
        <property type="entry name" value="Leuzip_Jun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021755">
        <property type="entry name" value="TF_Aft1_HRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021756">
        <property type="entry name" value="TF_Aft1_HRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020956">
        <property type="entry name" value="TF_Aft1_OSM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19304">
        <property type="entry name" value="CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11786">
        <property type="entry name" value="Aft1_HRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11787">
        <property type="entry name" value="Aft1_HRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11785">
        <property type="entry name" value="Aft1_OSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00043">
        <property type="entry name" value="LEUZIPPRJUN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="436"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="138"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="217"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="280"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="461"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="321"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="406"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI08499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="550" mass="57603" checksum="2410D47439E6A69E" modified="2018-11-07" version="1">MGTSPASARSRSKSPTPANNKPSRQDLPPDVKTASVGKLEGSSNAEVAKPLAPPLRPQSQQAPGGSQTPDFFAPQVGGSLSLEPNPFEQSFGGGGPETPGGTKLPPVAALTSPSSLLPGSNATPFNWGGGSLRTGPLSPAMLSGPANDYFSDTHHLRGGFPTPNESSLRSGLTPGGSGSMFPAPSPNSQALFAQLASGGATPNTLDFHRTALSAAVKREQGAANAQQPPQAPTSSAPQQEAPNGPSTEKTEAKPATGPFDPHDNDAANGLFMLAQGGQARNRTQNTAHFPPAAAPAPAPTAAPAVAPPVSGPGHAHPAPASTLNHEVTSQVASHPAQVNSVRAASDNSNVSEDGMHMKPTSRTKGKKNSLGSNSNGRRKADDVPTKVPAAKKAKVNNGHSNGMLDMSDEDDEDEDEDDMRGKFEDGGGAKSKMTEEEKRKNFLERNRVAALKCRQRKKQWLANLQNKVEMYGTENDALTTQVTQLREEVVNLKTLLLAHKDCPVTQQQGIHSAFIAQMEPYNAQMNPYGMAGPIPNQQVMPGQNVQRRFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L253</accession>
    <name>A0A367L253_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sm protein F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_8869</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L253"/>
    <dbReference type="STRING" id="1330021.A0A367L253"/>
    <dbReference type="OrthoDB" id="5364946at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01722">
        <property type="entry name" value="Sm_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034100">
        <property type="entry name" value="Sm_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40625:SF2">
        <property type="entry name" value="GTP-BINDING PROTEIN ESDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40625">
        <property type="entry name" value="GTP-BINDING PROTEIN ESDC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="3">
        <location>
            <begin position="7"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="379"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="488"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="565"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="111"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="507"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="569"/>
            <end position="580"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00030144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI08495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="602" mass="65681" checksum="1AA89C49CB907EB7" modified="2018-11-07" version="1">MSFVPVNPRPMLTALVEKTVSVRLKWGEMEYRGQLKAIDSYMNLQLESTKEYTGGTEGGHLGQVLIRCNNVLWIRGVDANENGDTKMDAGYRAGTWNGRTDERDGERKETGAQTAQQERGQPTRAAKEMHSEMDRNCTDVDTLTKTLFTHGRRRGIPLPPSSAPLSAERDMALFIGRRRQPCVGGSKEGGPLVLLSSSSSSSSSSSSSSLLSFFLSSVASLCPSIDRLWCFFFLSRRAGPLLPLLLSPLIIPPFSSFKLSPKLCCRSAPQDETAFLLYISVLLFIPWTTFSQHTVVRQIMSAIQLSFSLRVSSGVKTVHLLGSWDGYAGQLPLSKDRSSSSKSGTWKGTFRFQNATLEAGQRYWYYYIVDGYHVAHNPGVSSTTEPTTGRELNILDVPSDNKKSSRTSSSSSSSKSSSSSRQPSSRSANKEHPRSSRGSLSVDIPKGRPLSVSQIKAPKPVSPQAAKHILDTDYCDDDTLEELTARFGGAGLDDNEPSYHQHHLGMSPVSSSGSSSLSYRSDSSSASSSRSGYSTPSSDCSSCTCERYGITRKGERVKLDCGGQRCGFGDESSSCSSSGSDSEREPARYVKRSQRRNGIVVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2P9</accession>
    <name>A0A367L2P9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kri1-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_8786</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KRI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2P9"/>
    <dbReference type="STRING" id="1330021.A0A367L2P9"/>
    <dbReference type="OrthoDB" id="10252032at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018034">
        <property type="entry name" value="Kri1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024626">
        <property type="entry name" value="Kri1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14490:SF5">
        <property type="entry name" value="PROTEIN KRI1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14490">
        <property type="entry name" value="ZINC FINGER, ZZ TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05178">
        <property type="entry name" value="Kri1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12936">
        <property type="entry name" value="Kri1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kri1-like C-terminal" evidence="3">
        <location>
            <begin position="471"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="142"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="297"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="388"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="561"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="142"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="300"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="389"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="414"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="429"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="564"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="584"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="600"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI08492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="610" mass="70367" checksum="20F4A7F9477460B2" modified="2018-11-07" version="1">MSPSAQPGPPKRTILEDSDSDSDGEALTQGEGEAFKVNEAYARRFHHNKEREEREKLEKKYGKADDSSSSESEETEDEDGFLATEALDAQISATLKAIRTKDPRVYDKNVTFIELPDDEEEEEAVRGKGKKEKPVYLHDYQREKLLRGDADGEEKKVPPTYMEEQDALKKSILSGIHASGADEESDSSDDDDGGFLKRKESDGIHPSRRPNVKKTVGEMDVASADKDPEKFLSNFMASRAWIPEEGTKWKVFESDDGESDADEAAEEWEHAYNMRFEDPSKSNEVLRSYARDFAAARSVRRQEKTGRQRQREAEREKKEHESRKKAEEKARLRKLKLEESAEKLRKVKQAAGAVGKKVKEEDWMRFLDEEWENDKWEEEMQRRFGEEYYALDDVEEEEEADDDAKKKRSRAKKPKWDDDIDIKDIVPEFADDNEDDDDDDDDGDDDGEKRSRKRRKTTKLAPEERTRLASLVDTKLLHDPSTTTTTTTTFRYRETSPQAFGMTALDILLAPTDQSLNKFASLKKLAPFRDAHKKSRDGKSLAKRARLRQWRRDVFGHAHAPFIPEEKGGAEAAEKMREGEVKKEKKRRRKKKKEKTMMMMEDEEDVEAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L349</accession>
    <name>A0A367L349_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_5003</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI08861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L349"/>
    <dbReference type="STRING" id="1330021.A0A367L349"/>
    <dbReference type="OrthoDB" id="7305308at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000086">
        <property type="entry name" value="Acetyltransferase, GNAT family, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051016">
        <property type="entry name" value="Diverse_Substrate_AcTransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545">
        <property type="entry name" value="DIAMINE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10545:SF29">
        <property type="entry name" value="GH14572P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="12"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI08861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="177" mass="19562" checksum="E43A62065F7E50DD" modified="2018-11-07" version="1">MSSSSSSSSSTATVRQATRQDVPAILSLIKALAVYEKEPDIVEATVESLQSTIAFESESTSPSRPARCLLAVTPGGEAVGMALYFYNYSTWRSRPGVYLEDLFVQPSERGKGYGKRLLVELAKHVVAIDGRRLEWAVLKWNEPSIKFYESIGAQPMNEWMTMRVDGSALDKLAHLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L390</accession>
    <name>A0A367L390_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_4986</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI08868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L390"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI08868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="73" mass="8525" checksum="E5257E19FB45B6E7" modified="2018-11-07" version="1">MFVQYKRSSRRIYELSLLLWRWLIPARSVCRLPGPAGKVGPEPKPVGTGWFWHNKESTVFLHRQISHLSIHAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3D1</accession>
    <name>A0A367L3D1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methylthioribose-1-phosphate isomerase</fullName>
            <shortName evidence="6">M1Pi</shortName>
            <shortName evidence="6">MTR-1-P isomerase</shortName>
            <ecNumber evidence="6">5.3.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">S-methyl-5-thioribose-1-phosphate isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Translation initiation factor eIF-2B subunit alpha/beta/delta-like protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MRI1</name>
        <name evidence="7" type="ORF">L249_5138</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5-(methylsulfanyl)-alpha-D-ribose 1-phosphate = 5-(methylsulfanyl)-D-ribulose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:19989"/>
            <dbReference type="ChEBI" id="CHEBI:58533"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="EC" id="5.3.1.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 1/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.23" evidence="6"/>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI08940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3D1"/>
    <dbReference type="STRING" id="1330021.A0A367L3D1"/>
    <dbReference type="OrthoDB" id="2461at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00874"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.420:FF:000003">
        <property type="entry name" value="Methylthioribose-1-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10470:FF:000003">
        <property type="entry name" value="Methylthioribose-1-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.420">
        <property type="entry name" value="translation initiation factor eif-2b, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01678">
        <property type="entry name" value="Salvage_MtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005251">
        <property type="entry name" value="IF-M1Pi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011559">
        <property type="entry name" value="Initiation_fac_2B_a/b/d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027363">
        <property type="entry name" value="M1Pi_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00524">
        <property type="entry name" value="eIF-2B_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004326">
        <property type="entry name" value="PRK05720.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00512">
        <property type="entry name" value="salvage_mtnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475:SF1">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 6" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="6">
        <location>
            <position position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI08940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="393" mass="41683" checksum="C56ED2B2D3D586BB" modified="2018-11-07" version="1">MSALEAVRYSRGRLQVLDQLRLPHEFHYDNVATRADAHDCIASMRVRGAPAIAIVASLGLAVELANKEPKPASAVEAQSSILDGLAYLATSRPTAVDLGNAVTLLADRVRSEAAKPEANGASVIAAYLDEAEALLARDLDTNLAIAGFGAEWLCARSGASSDAPVSVLTHCNTGSLATSGHGTALGIVRTLHARQLLRHVFCTETRPYNQGSRLTAFELVYEGIPSTLITDSMAAALFLTRGACVNMAAVIVGADRVVRNGDTANKIGTYQLAVVARHHGIPFMVAAPTTSIDLKTEKGDNIRIEERKPQELTQLTGAVVRSDGSIDKDTKVRVATADQIINVWNPAFDVTPAELIDVIVTEKGAVAKGPGGTFDFSKVMPEQWAKVLADRGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3S0</accession>
    <name>A0A367L3S0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylinositol-specific phospholipase C X domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5103</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI09070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3S0"/>
    <dbReference type="STRING" id="1330021.A0A367L3S0"/>
    <dbReference type="OrthoDB" id="7984201at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF146">
        <property type="entry name" value="PLC-LIKE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26146">
        <property type="entry name" value="PI-PLC_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016677698" description="Phosphatidylinositol-specific phospholipase C X domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
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        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
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        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <begin position="3841"/>
            <end position="3851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="3853"/>
            <end position="3874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="3956"/>
            <end position="3965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="4030"/>
            <end position="4041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="4049"/>
            <end position="4081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="4089"/>
            <end position="4106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="4134"/>
            <end position="4175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="4214"/>
            <end position="4241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="4262"/>
            <end position="4281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="4291"/>
            <end position="4314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="4326"/>
            <end position="4346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="4368"/>
            <end position="4385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="4392"/>
            <end position="4426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="4427"/>
            <end position="4454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="4455"/>
            <end position="4466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="4479"/>
            <end position="4501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="4750"/>
            <end position="4759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="4798"/>
            <end position="4816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="4840"/>
            <end position="4856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="4857"/>
            <end position="4871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="4878"/>
            <end position="4891"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="4908" mass="493507" checksum="0EEBF3B5C6D58CFB" modified="2018-11-07" version="1">[encoded data, 4908 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4A4</accession>
    <name>A0A367L4A4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ELYS-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_1408</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4A4"/>
    <dbReference type="STRING" id="1330021.A0A367L4A4"/>
    <dbReference type="OrthoDB" id="20729at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="entry name" value="ELYS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13934">
        <property type="entry name" value="ELYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELYS-like" evidence="3">
        <location>
            <begin position="38"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI09241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="327" mass="37616" checksum="3D09D7B41567050B" modified="2018-11-07" version="1">MLMHSRYDDVFHAKLKFPYDRTLQHEIEHHRKAQGGLLFIDRVMKALGVVKGSSSSVIDLSVGSQLTALEGRMYPPKSENALRQLHQLFCETAMAVHHKQSLLYYIMLDFDTVASQSSESQKFAADVGMPVNYQTFMKGLWLMDRQRYQEALEFVTHPSLTPDFADDIITTLVRYAPDHDYSLVLSYFYTVRPSLKSASALELLFDAMVQADATEALLFSRTHPQHTRQQLFRRWVRINLKQGRRGEQPSQRDRLAFLPLDSVEEKWFEQYLTVGEGKNLPKAKDTLLARQIACDRFSDVSEEQKVDERWAAVVEGIKRGVGATHSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4E6</accession>
    <name>A0A367L4E6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_1553</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4E6"/>
    <dbReference type="STRING" id="1330021.A0A367L4E6"/>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF80">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="2">
        <location>
            <begin position="58"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI09305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="292" mass="31584" checksum="E889EACABECF7B3A" modified="2018-11-07" version="1">MADEDVATKAPESDAVVGEHCVADRPTPSDQSSTGEIINFNDVQVYISKPADYPHAPSRFLLLLTGGTGIKSINNQIQADKYAAAGFLVLMPDLFDGDTAPVATAITDDSASMLDRFKIKAVEVTKSFLIDMWLARVTPDKVMPILHRVIDAARDRYADAIDNGGGIYAVGYCVGARFVLLLARDMRDRYAASRGPHIKAGALAHPASVVPDDFRHLKAPLSWVCIEDDPLFPDAVRAAGEKAMSDANLEHEVKVYPGVPHGFAVVGSYDDATINDAQATAYDQMLNWIQGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4G2</accession>
    <name>A0A367L4G2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_5047</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI09102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4G2"/>
    <dbReference type="STRING" id="1330021.A0A367L4G2"/>
    <dbReference type="OrthoDB" id="1875751at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF95">
        <property type="entry name" value="NUCLEOLAR PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="87"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="209"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI09102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="389" mass="42329" checksum="3CAFD4FB713DB1EB" modified="2018-11-07" version="1">MAVKTEKAAADSSPEKAAKASKRKASAASDLEIDLSAPEPPSKRARRALKKGRSVSKTAGGAGSGAEEEQDGSGDDAGKDKKARSEHGIWIGNLPFTVTPAELRQWLVDHSGEVITSESVTRIKMPKTAGEGKGTAGRGINKGFAYVDFIDLSTQVAAMALSETELGGRKLLIKDATSFEGRPSCKDKEEQPTTTAKEGDGDGDGGGSRKIFVGNMSFKTTEDDLARHFAKCGEIESIKMATFEDSGTCKGYGWVRFLEAQAAASAVKGFIKIKEKIETHRDFGGDDDDDDDEGKGGEYEGEEKPRFKTRKWWVNQLLGRRLRLELAEDDQTRYRKRFGKDAIKHKVADSVVKKSTETQEEPKKTEQDIATARLMGTLVEHKGTKVTFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4Z8</accession>
    <name>A0A367L4Z8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_4080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4Z8"/>
    <dbReference type="STRING" id="1330021.A0A367L4Z8"/>
    <dbReference type="OrthoDB" id="2240312at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000500">
        <property type="term" value="C:RNA polymerase I upstream activating factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000182">
        <property type="term" value="F:rDNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001181">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039601">
        <property type="entry name" value="Rrn5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28079">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28079:SF1">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="96"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI09506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="531" mass="60189" checksum="9F40A9DF63C577C8" modified="2018-11-07" version="1">MSNDDDDSDSDYNVIDDQSLSASDSQQPNDTTALSASSAGTARKRKRRLPPAASPFKRQRAIFNADYLDLLNHDIDDAANRACLDDDFDLPPNQVGLTSWSSLEKQLFFEALARLGRHDLPGIASRVGTKSVIEIRHYLHYLKEADAIRNQQAGDSFLEVAEYPAAVELSQQCCHALEQAADAISLRQENEEMKREAKKWGDCWNVTPDIAEQLVVGDDEDPSDAQPPPAFAQLFDLPRWLQLSEQVLMNSSVPGDNWHSVGSDTPSIWATALDDFYSLAVSLTRRLVQTTLFISMSRIRSKKRIVPRTRDIVRRRDVEAAVKSLGLTPNTWHFWLTSARRLRLRVCRQLPATRNDGAEEEPMTFDELEAELGAEQDDQDTAGTQATIQPDDSSTSEDDEQLPDVSVKDEPLSSDQEQQEIAREANEVLWYTAADLRDVERARRPLERRIAMERRQEEQAQEWDAYASYQAELSMWSMLRETPPQDMPKAQEPAQLERSKLDVEGMYSGGGDWTSHLTFRDEWEAAEDRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5J7</accession>
    <name>A0A367L5J7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab GDP dissociation inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_4094</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Rab GDI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5J7"/>
    <dbReference type="STRING" id="1330021.A0A367L5J7"/>
    <dbReference type="OrthoDB" id="9446342at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005093">
        <property type="term" value="F:Rab GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.405.10:FF:000001">
        <property type="entry name" value="Rab GDP dissociation inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000806">
        <property type="entry name" value="RabGDI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF8">
        <property type="entry name" value="RAB GDP DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00892">
        <property type="entry name" value="RABGDI"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI09705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="486" mass="54185" checksum="3E896914BC1FAB23" modified="2018-11-07" version="1">MDEIAKEYDVIVLGTGLTECILSGVLSVKGRRVLHIDRNSHYGGPRLLISRRYQKLYPFFSPDPIHQSLTFNIQLFKKYGNYQKGEEPWKKYGRPNDWNIDLIPKFLMSSGELTNILVSTDVTRYLEFKQVAGSFVQQGADSKATVAKVPSDAAEALKSSLMGIFEKRRMKSFIEWVGQFDVKDPATHKGLDMNECTMKDVYDKFGLEATTRDFTGHAMALCATDDYLNVKGGAPEIIERIRLYGNSVSRYGKSPYIYPLYGLGELPQGFARLSAIYGGTYMLNTSVDEILYEGDKAVGIKATMSTGTEDVKFETKSKMILGDPSYFPGKTKVVGQVLRAICILNHPLAGTSESDSCQLIIPQSQVDRKNDIYIACVSSAHNVCPKGYWIAIVSTIAETAANHHLELQPGLERLGKIEEQFMGPPIPVYEPLESGTKDKLFISKSYDATSHFETTTDDVKDIYRRCTGEELKVEGLREGINVTSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5P7</accession>
    <name>A0A367L5P7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Splicing factor subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_3930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the SF3B5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5P7"/>
    <dbReference type="STRING" id="1330021.A0A367L5P7"/>
    <dbReference type="OrthoDB" id="274726at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009846">
        <property type="entry name" value="SF3b5/RDS3-10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017089">
        <property type="entry name" value="Splicing_factor_3B_subunit_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978:SF0">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07189">
        <property type="entry name" value="SF3b10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037010">
        <property type="entry name" value="Splicing_factor_3B_subunit_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI09749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="84" mass="9621" checksum="B040437A3F2568F3" modified="2018-11-07" version="1">MADKLRTQQELERLQAKYVGTGHPDTTSWEWKTNIQRDTFSSIVGHRPLLTLVALAENEPISKVRTNLIRKMIQPCGPPPPREE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L677</accession>
    <name>A0A367L677_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutaminase</fullName>
            <ecNumber evidence="2">3.5.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_8611</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaminase PdxT/SNO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="2"/>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI09927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L677"/>
    <dbReference type="STRING" id="1330021.A0A367L677"/>
    <dbReference type="OrthoDB" id="2039at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903600">
        <property type="term" value="C:glutaminase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008614">
        <property type="term" value="P:pyridoxine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01749">
        <property type="entry name" value="GATase1_PB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01615">
        <property type="entry name" value="PdxT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002161">
        <property type="entry name" value="PdxT/SNO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021196">
        <property type="entry name" value="PdxT/SNO_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03800">
        <property type="entry name" value="PLP_synth_Pdx2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31559:SF0">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01174">
        <property type="entry name" value="SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005639">
        <property type="entry name" value="Glut_amidoT_SNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01236">
        <property type="entry name" value="PDXT_SNO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51130">
        <property type="entry name" value="PDXT_SNO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="7">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="68"/>
            <end position="70"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="166"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR005639-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR005639-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI09927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="232" mass="25266" checksum="1022AD45CBF587D4" modified="2018-11-07" version="1">MTVSSRRDSTEDGSLTVGVLALQGGFAEHVRLLRRAGDSVSRPSPLRVIEVRTPPQLARCDALVIPGGESTAISLAATQAGLLEPLRQFVKVQKKPTWGTCAGLILLSEHVNATKKGGQELIGGLHVRAHRNHFGRQLESFITDLELPFLAGDDCVPTTPFPGVFIRAPVVEEILEDASVKVLARLPPHANNGAGEMIAVRQGNVFATSFHPELTSDARIHVWWLREIIRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6H2</accession>
    <name>A0A367L6H2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6H2"/>
    <dbReference type="STRING" id="1330021.A0A367L6H2"/>
    <dbReference type="OrthoDB" id="5404323at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="478"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="529" mass="58636" checksum="84BDCF42889BA502" modified="2018-11-07" version="1">MFLHAGAGLHGHEYSVRTSNSDHAPTLHKSTLLRTALRPLAAESGTPSRSTPRHAYRLSVALDDLSSSHQLPPSDARKELAVRFREPRTDQSEDDASVAGTEVGTDTASERGSVRSTSVRRPRRQRAPRKSTRYALALPPSHLRHKQRRLVQIRPRLLLQLQEVGDRRAMPSFDVVPSCPLAGNIFSPLLARRFPRIFRARPQLSQDQVLVVRSDHTGPPSVSGINDRDVLAVISATHDGCAAISLDDGSTWEASPKANGSFEFTTVDEQDRIIMARWVRRWSAPTGKRGSESTGGSTSPPPGLRWTFSLINPCTRRHPVMGSLTPDAVDVYDSFHTLSASSGLYPPTRAFTDDATAAERTTVMVTQRQKNLMLATATWISLHWQGWPDLPNSRMSFLGGPGRRQTFDGFDGDGAIEGHKVASRKTWPPSFQSPPSWASSTKRHGTGQDGLPHPKPNSFLPRRGSHSKQQQQQRKKTSTTTTTTTTTTTTTICRSRMWPWLQRLMNRGKSRERRTHEEQTLEKVTAPGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L735</accession>
    <name>A0A367L735_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">YTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_8534</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L735"/>
    <dbReference type="STRING" id="1330021.A0A367L735"/>
    <dbReference type="OrthoDB" id="6103986at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990247">
        <property type="term" value="F:N6-methyladenosine-containing RNA reader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21134">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007275">
        <property type="entry name" value="YTH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045168">
        <property type="entry name" value="YTH_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357:SF3">
        <property type="entry name" value="YTH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12357">
        <property type="entry name" value="YTH YT521-B HOMOLOGY DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04146">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50882">
        <property type="entry name" value="YTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YTH" evidence="2">
        <location>
            <begin position="132"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="304"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="332"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI10234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="355" mass="38958" checksum="1D15D85D21B01B62" modified="2018-11-07" version="1">MSPPPPRTDADAKKPLSSLSNSIHDTEGRLRRLVKDDADLQLWLQHTRYFDLGHRKRVLESIRKLKVVEEEREKLMLELRLAQASSSSSPKLPPRLRSTSASVTDEGSVADDDVAVASHSSTTRAAKVATDTRFFLVKCFNTANIYMSQRDGLWVTQTKNGDVFSQAFNDCQSVILFFSINKSRGFQGFARMMSVPDAALPKPDWIQKINLKAATDPFRVEWINTAVTEFDQVGDLKNPLNEFRSVVVGRDGQEYPPECGLKMMALLSQAAIKPSYAAAAAAANNNSAVTIPSRLPLMNSLQNASPSASVAPPSSRPWRASRHRDASPTPLPAASAPSLSVELSSQKSHPNLIDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8A2</accession>
    <name>A0A367L8A2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">KRR1 small subunit processome component</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">KRR-R motif-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_4448</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. Essential for vegetative growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3. Interacts with snoRNA U3. Interacts with MPP10, KRI1 and with ribosomal proteins RPS1A, RPS4A, RPS4B, RPS8A, RPS8B, RPS11A, RPS11B, RPS13, RPS24, RPS25, RPL4A, RPL7B, RPL8, RPL23, RPL25 and RPL28.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
            <location evidence="1 11">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the KRR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8A2"/>
    <dbReference type="STRING" id="1330021.A0A367L8A2"/>
    <dbReference type="OrthoDB" id="441223at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22393">
        <property type="entry name" value="KH-I_KRR1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22394">
        <property type="entry name" value="KH-I_KRR1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000011">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000014">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041174">
        <property type="entry name" value="KRR1-like_KH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048550">
        <property type="entry name" value="KRR1-like_KH1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048548">
        <property type="entry name" value="KRR1-like_KH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048549">
        <property type="entry name" value="KRR1-like_KH2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024166">
        <property type="entry name" value="rRNA_assembly_KRR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581">
        <property type="entry name" value="HIV-1 REV BINDING PROTEIN 2, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581:SF0">
        <property type="entry name" value="KRR1 SMALL SUBUNIT PROCESSOME COMPONENT HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17903">
        <property type="entry name" value="KH_KRR1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21800">
        <property type="entry name" value="KH_KRR1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006515">
        <property type="entry name" value="KRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 11" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="6 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="K Homology" evidence="13">
        <location>
            <begin position="116"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="229"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="253"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="316"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI10649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="341" mass="38808" checksum="AA85136C74FEAA06" modified="2018-11-07" version="1">MPKTRPKDDAQPAGGDQADKFKLDEKFGGAVVQESSFATLFPKYREVYLKEAWPLVTKALEKRGIACTLDLIEGSMSVKTTRKTVDPGAILDARDLIKLLARSVPAPQAIKILEEGVACDVVKIRNLVGNKDRFVKRRQRILGPNGSTLKALELLTDTYILVHGNTVSAMGPYRGLKEVRRVVEDCMANIHPIYHIKELMIKRELAKDPELASENWDRFLPNFRRKTLSKRRVPHKVSDKSKKTYTPFPPPPEKSKIDKQIESGEYFLSKEAKDRAAQKERKDKQKERKQERTKEREADFVPPEEGERPKKKRKKMEAPVTERGDARHNSLPSPLSPHQLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8T9</accession>
    <name>A0A367L8T9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_5263</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8T9"/>
    <dbReference type="STRING" id="1330021.A0A367L8T9"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000012">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF177">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="429"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="503"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="39"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI10843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="545" mass="58010" checksum="19C9CEB3EDDA5980" modified="2018-11-07" version="1">MERPSFSSSGSEDGEKQDGGKPENTRNHEYPPGYKMVLIVLALVLSNILLSLDMTIVATAIPRITDEFKGLDKVGWYSSAFFTFSAAFQSTWGKIYKYFPLKTAFLIAILIFELGSAVCGAARNSETLIVGRAIAGMGAAGLGAGSYTIIGLSAPPRQRPALTGVLGAAYGLASAIGPILGGVLTDKLSWRWCFYINLPVGGISAVVIFLFFRAPATTTEQATLGEKLRQMDPAGIVLVIGATICYTLAVQYGGVSHPWGSSLVIGLVVAFAVLVACWVILHRYQDERSMVPPRLVRDRRNLTMFAFTLIFSGGYYTAVYFLPVYFQSAHNSSPTRSGIENLPFIITISVSTSLTGALVAITGRYKLLLVGGGAAAAVGAGLLTTLDQNTPAGNWIAYQIIAGIGWGIACQIPLIAVQGNVSTKDLASATGMLLFFQGIGSAYIVSGAQAAFVNKLVQSVKEAAPEVDKTALVQIGATEIRKAFTERQLQSTIIDCYVYGIRVAFYFCIVCACLATVIGLTAKGQKLGEATSEKGEKDYPTNVQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L926</accession>
    <name>A0A367L926_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5165</name>
        <name evidence="2" type="ORF">L249_5983</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">BCC 54312</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-10" db="EMBL/GenBank/DDBJ databases">
            <title>A genome scan of diversifying selection in the zombie-ant fungus Ophiocordyceps unilateralis complex supports a role of enterotoxins in coevolution and host-specificity.</title>
            <authorList>
                <person name="Kobmoo N."/>
                <person name="Wichadakul D."/>
                <person name="Arnamnart N."/>
                <person name="Rodriguez De La Vega R.C."/>
                <person name="Luangsa-Ard J.-J."/>
                <person name="Giraud T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L926"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI10930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="44" mass="4928" checksum="C0D397EF79DEA1FD" modified="2018-11-07" version="1" fragment="single">HSAYSGVGSIGLTRTSLPPNHRSSKYVRVLQVGTLKYLEKYLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L946</accession>
    <name>A0A367L946_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5378</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L946"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI10953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="40" mass="4690" checksum="AF4643E6313936BA" modified="2018-11-07" version="1" fragment="single">RSIRSIGSTRTSLPLNRRSSKYVRVLQVGTLKYLEKYLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L965</accession>
    <name>A0A367L965_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Probable vacuolar protein sorting-associated protein 16 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_5292</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Essential for vacuolar protein sorting. Required for vacuole biogenesis, stability and to maintain vacuole morphology.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the VPS16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L965"/>
    <dbReference type="STRING" id="1330021.A0A367L965"/>
    <dbReference type="OrthoDB" id="1792at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.780">
        <property type="entry name" value="Vps16, C-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016534">
        <property type="entry name" value="VPS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006925">
        <property type="entry name" value="Vps16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038132">
        <property type="entry name" value="Vps16_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006926">
        <property type="entry name" value="Vps16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04840">
        <property type="entry name" value="Vps16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04841">
        <property type="entry name" value="Vps16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007949">
        <property type="entry name" value="VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vps16 N-terminal" evidence="5">
        <location>
            <begin position="8"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Vps16 C-terminal" evidence="4">
        <location>
            <begin position="501"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="810"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="823"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR007949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI10971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="840" mass="93066" checksum="FBAB0125573FE057" modified="2018-11-07" version="1">MESLHARADWESVGDKWFRKTQQYTAVFDQDLDLDNYIVAGAPYAGALALWRDDSKLQPGTWTKPTIDIYSLTGKKLRSIPWDKTSVRGLGWSEDESLLVVTVDGNVRCYDLQGDFSNFSLGHGADNYGVESCRFYDNGMVALLGNNTLVAVSSYAEPRPKSLATCPSGEIHSWAIVSPDHTLSRSVEALLSIGSTVYVVDATDCEDRLLDMGPFSHISVSPDGRYVNLYGSNGKAHVISSDFQDKLLEHNSDSQTPPKYVEWCGSDALVAWEDEVHIIGPGEQSTTFIYESTRVHVISEHDGARLITNDFCEFVERVPSDTLEVLGPASESSPASILLDAVGQLERESPKADDYIQLIRPSLTEAVDTCVNAAGREFDTRWQKRLLRAASFGKSVLDMYNSDEFVDMCETLRVLNAVRGYETGIPLSYEQYHRLTPERLLRRLLQRHDYLLALKMAEHLKLPTDRIYVHWASAKVRAGTTEDDESICQLVVARLSGKPGISFEEIARAAYHEGRARLATELLNHEPRGGRQVPLLLDMEEDELALDKAIASGDTDLMLMVLMQLKKKLPLAAFFRAVNARPTATAMVEAVAARDGDNGLLKDLYYQDDRRVDGANVFVREALRQPDARTASDKLALGAKLLADGKESAAAEMQALREAMSLLRTQAMLGRDLGESFTGLSVNETLFKLIRLGFNGQAKKVQGEFKVPDKVAWWIRLRALVAKRDWAEIEEISKAKKSPIGWEPFFNLTLQAGNPRLASVFIPKCTGGGETVTMYEKCGMRTAAAAAAVRLKDEAGWRRLLEAAGRGSQEGREIERLGGGGIWEEEVEEEEGGDEEGVIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9P0</accession>
    <name>A0A367L9P0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SPIN90/Ldb17 leucine-rich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_7499</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9P0"/>
    <dbReference type="STRING" id="1330021.A0A367L9P0"/>
    <dbReference type="OrthoDB" id="445362at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030125">
        <property type="entry name" value="SPIN90/Ldb17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018556">
        <property type="entry name" value="SPIN90/Ldb17_LRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13357:SF1">
        <property type="entry name" value="NCK-INTERACTING PROTEIN WITH SH3 DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13357">
        <property type="entry name" value="SH3 ADAPTER PROTEIN SPIN90 NCK INTERACTING PROTEIN WITH SH3 DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09431">
        <property type="entry name" value="SPIN90_LRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SPIN90/Ldb17 leucine-rich" evidence="2">
        <location>
            <begin position="207"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="462"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI11143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="518" mass="58211" checksum="EEAF646698D3E154" modified="2018-11-07" version="1">MGDVDESAMSPELAGSLWTVMGDVDESAMSPELAGSLWTELGELLSSTCESHESIDDALRGWLDVATQLRAHDPDSQDLVLGCAQMLLESRLFQDNKHYVRTQIIYSLLQEDDVGFLHAIVCLLLFDGRSDESTFPRMLDEACFARLLELLIAQRDEDDARLYRLLLQLLYEMSRVQRLETDDLALVQDGFIRCLFEDVEGVSDDSDDPYHYPTIRVLLVLNEQYMLASTDPAPDVDVTPTNRIIKCLSLHGPLFRSFGENMILLLNRETETSLQLLILKLLYLLFTTKATHEYFYTNDLRVLVDVIIRNLMDLPDEKMSLRHTYLRVMHPLLAYTQLCQPPHYKRDEVLRVLSILRGSDNAHFAPADETTLRLVDRVAKVDWMAGEEKEEESWDQAKVARKIFGVSLSPSQYASSASVDDVAGVMEKPGVQTPSRNVKAAAVDAASPDEVVAAVKTKRPLPAVPRHRHGNPVVGRMPTDVNGVEKKIPPKAPPPRRFGRMKAVEQAGPDVREAGFPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9W5</accession>
    <name>A0A367L9W5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_5189</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI11032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9W5"/>
    <dbReference type="STRING" id="1330021.A0A367L9W5"/>
    <dbReference type="OrthoDB" id="413079at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000286">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF3">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="340"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="250"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI11032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="430" mass="46433" checksum="08EA0DE5049599B0" modified="2018-11-07" version="1">MSDIHEPLLPPAPPGIGPVLRNAEDDDDDDDNGQHPPPERWNRPRGNVAKLAFASLSFALLGMNDASIGLEEYYGISYAYVSIIFLTPFVGYSIAAFTNAHVHQFLGQRGIAFIAPLCHIATYLVLATHPPYPVLVAVNALSGFGNGLVDACFCAWVGAMHRGNSIQGLMHACYSLGALFSPLLATSMVIKAHLPWYTFYYVMVGVAMTEFLGLCFCFWDKTGAVYRAEHLNDQGSSQAGMSEALKSPVTWLCALFFFTYMGAEVGLGGWIVTFMLRVRHASPFAAGLSGSCFWAGMAVGRALLGFVNERFGERICLTLYLVFCIALELVFWLIPNFVVSAVAVTFLGFFLGPMFPGGVMLMAKLLPKRNHVSAIGFAMAMGGSGGTVFPFIIGAIAASQGVGVLQPIIIGLIVLNITVWLSFPRVSTKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LA80</accession>
    <name>A0A367LA80_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Iron-sulfur clusters transporter ATM1, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Iron-sulfur clusters transporter atm1, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">L249_7621</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29 30">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Performs an essential function in the generation of cytoplasmic iron-sulfur proteins by mediating the ATP-dependent export of Fe/S cluster precursors synthesized by NFS1 and other mitochondrial proteins. Hydrolyzes ATP. Binds glutathione and may function by transporting a glutathione-conjugated iron-sulfur compound.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 22">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="29">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LA80"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140466">
        <property type="term" value="P:iron-sulfur cluster export from the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18582">
        <property type="entry name" value="ABC_6TM_ATM1_ABCB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03253">
        <property type="entry name" value="ABCC_ATM1_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11040">
        <property type="entry name" value="CYP7_CYP8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000004">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000287">
        <property type="entry name" value="Multidrug ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF402">
        <property type="entry name" value="IRON-SULFUR CLUSTERS TRANSPORTER ABCB7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="22" id="KW-0349">Heme</keyword>
    <keyword evidence="14 22" id="KW-0408">Iron</keyword>
    <keyword evidence="17 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 24" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="1555"/>
            <end position="1575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="1636"/>
            <end position="1663"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="1669"/>
            <end position="1689"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="1759"/>
            <end position="1781"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="28">
        <location>
            <begin position="489"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="25">
        <location>
            <begin position="489"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="25">
        <location>
            <begin position="541"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="27">
        <location>
            <begin position="1524"/>
            <end position="1812"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="26">
        <location>
            <begin position="1828"/>
            <end position="2065"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="33"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="213"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="302"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="752"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="893"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="23">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="163"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="236"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="23">
        <location>
            <begin position="312"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="325"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="23">
        <location>
            <begin position="367"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="23">
        <location>
            <begin position="772"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="22">
        <location>
            <position position="1387"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00039906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00040792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00045666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="RCI11325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="2075" mass="228241" checksum="A87B16C8DE9695C2" modified="2018-11-07" version="1">MADQMAHGEPVLPEGIGNFADGVDFESIDMFHNSVMPSDPEEFPPQVAFGSGQAPEAVMSEEPMPHSTKKKHRRHRHASSLMDSSADGTEKGKRRHKRSHMRDVAEVPNSQPVSARRSDFDLSAREQPSSSAYHVADGDRNLNPSYAVNHAPSSWPDPRAKRKTYESGDDRRRKKRRADDGGHEQQFRDADGAGLLASAAALLQSQNQLGLSLEPSSVTGQAVVGPDYRESHLRRQSQSGQTPWPENSVPNMDLDASHHVARDHSDVAALAREAWAEQQQHRSGQEVSLAVTQGIASAEAALAEKSSSQALSRKRPRTTRKKAKPTFYEQAQADATAADEGHGSLENAAGGGNGEETEFDDEDAPKPRGRAKKAAAKGKKTEKHTTSPTLQHDEGGGGGEEDGRRSRRNRLNGYTQGRFTDVELSHIAAAVESFRAEYNLTQQEVNGMIHAPGGTTAGDEHAQLWTRIFAQCPDRHRQKVINITRKKFHNFIARGTWTLEQDTELKELIGVHGKKWAKIAGIINRHPEDLRDRYRNYLVCGEKQRKDAWDESEEANLTQYVINSMEAIDELRNTKPNPLLVSLTYEELIDWQNISELMGRTRSRLQCITKWKSLNIRTHGQDKLVSSQPDAPISFRLEKARRQLAAMPQDERYRLTLAIQKTNVGKDGKIPWQRLVDRPFRNRWHRSTQMLLWRRLRQSIPDGEDKATRDCASYLTERYDQTGHLPDVDNIEVDDAQEMDFILAMPPAFTGMNSAAGGREHGEGGGGKSAEFVEDSDVDEPDVDADADADADADADADADADADADADVDVDADADADADGDVDADAKDTTGGIGGAIEQEDAADEADLGRVAVEREQRGDERQLEREADGVDLQIDPALVPATTAPVVAKKTTIARKTGSGKPPSRRAPNKAPTAVMEPIEDVVEERQGVGGAAAAAAAAATMTTTATMTTTTTTTTTTIQAMALDANGFLARLRDCYPEGVFSLRLCGGLHHFVHGPSMTTTLLNRPKTAAETLSSGILVTNFGFSEKDRQHHASLAEESKQNFRLLLSEPGLGDLVEATVGHVRSRVGNLVSFRDGDHQPPWARLAGAERVGDGLVAVELTDLVRNFVAMTANRALFGSDFVDNMEELWPCLWAFDQGFLLLAAKLPGWIPWPKLRRARAAQGELLRHAREFNLAMDREDPGPDWRRLSEVSAFVGARVRTYRRHGLSLDARASSDLALLWATNANANQLVPWMLFEIYRHPHLLAAVREEVRPFVVLGPGGGGIETVDVGGLLELCPRLKASYVETLRLYTGPWTMRRLREDVVIGGRRGEGGKNREEMYLLRKGSFAHVAHEMHHCDPAFFPDPEVWMCERHLREVDDGHGRKRMVADMGTLRPYGGGPAMCKGRAFALRELMLYAAVIVSLYDMRPADGEEWPAPETYKLVATRHSKTPIRLWHQQMACRRAAACRRDPSLASKDVVVVAVVVVVAARDAQGEAAKASTDDKKTPAEQRTADWAIVRHMSRYLWPRKDGLGTKLRVGLALALLLGAKLLNVQVPFYFKSIVDAMDVDAAALGGTAAAVAGSLILAYGAARIGAAVFQELRNAVFASVAQKAIRDVARNVLHHLLRLDLSFHLARQTGGLTRAMDRGTKGISFLLSSIVFHILPTALEVSMVCGVLTWQYGVRYAAITALTMTAYTAFTIWTTAWRTRFRRQANAADNRASTAAVDSLLNYEAVKHFGNERYEVARYDAALAEYERSSIKVATSLALLNMGQNVIFSAALTAMMLLAADGVAAGSLTVGDLVMINQLVFQLSVPLNFLGSVYRELRQSLLDMGALFSLQRVPIRFDKVTFGYRPDGPPILRDLSLTIPAGGKVAVVGPSGCGKSTLLRLLFRFYDVDGGRILIDGQDIRDVSLESLRGNIGVVPQDTPLLNASVEDNMRYGRVGASREEVVEAAKRAHVDEAIRRFPDGYQTMVGERGLMISGGEKQRLAVTRVLLKDPPLLFFDEATSALDTHTEQALLASINSILRERRRTSVFVAHRLRTILDADLVVVLKDGSVAETGTHRELVERGGVYAELWNDSPFGIWTDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAD8</accession>
    <name>A0A367LAD8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAD8"/>
    <dbReference type="STRING" id="1330021.A0A367LAD8"/>
    <dbReference type="OrthoDB" id="3034003at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="705"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="804" mass="89058" checksum="F8D27D130554F55C" modified="2018-11-07" version="1">MAELTVAYVAGLMAFAFFLARIVSPNALAFICAKHLGFRNSAATWTTGSKVLQQSNWPFILQTDDAYDDNVRRSILWTSRLMPAISILLSVASVLTPMGLYSSTADGKPVKATFVYAPDPTAFGLHGTMRRNGYAETRACGGVSYGNESFRYNVKPCPSSKDGDDTLMHSPDPTRPSSVCCLDVDLPASIKDVYSSGYKNSTVSSFFDIQWRQYALSTRPGYLNGSAYMIGQWRNVESVLFDEAYSVVEGLIVDTINGRIGFRNHTIPIGFDRAVSWEEDLLFIEPETVCVDSNLTLDYTKDVRLSWGPWPVSRVDLTDRGGFSNLDLTMPSVDLTNPQKNPDLRGRASAAAWMHNVLNAMWFNVTGPTLPPTHMKSSMNQSYPYRGALMTGYPDFSLSKNFYHEFWVYQGRPGFHVFARDSTSPDTSNATFEMRLSNYSRINDICRGINESSPATSRNMLISCGLLQSIPQRTDGGDAFNQEDGAKWMKKLYSCASATKATIKTVTLSYNDTGDDDSRLAGLSALAIRDKQYPDEASMPLWAVEDVGNRYLAGEIGLIWGLISPEHEGRANLTTYRQPWLYLPGRMSTWNDQIPFMSDGSNLAGSDFASNMWLAAYCNNLDREARHLASFENCDSKQIYKASSNIAMWTKWQRLTAQAGTASQVANLIFTDFAASAVVGVKPRNRHEQFLVTPRVLVIRYKLPYAVPALVSAAVVCAVVCVSVVFACTGKDEGLAGIRKHVQRLSPGRIYTTVLASPGEGSDLTMQSRDWNRRFGARLIDLSQEYPTAMQKTGEEESDEMASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAF6</accession>
    <name>A0A367LAF6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_7207</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAF6"/>
    <dbReference type="STRING" id="1330021.A0A367LAF6"/>
    <dbReference type="OrthoDB" id="10264376at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051858">
        <property type="entry name" value="WD_repeat_GAD-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017">
        <property type="entry name" value="GASTRULATION DEFECTIVE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="91"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="203"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="27"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="445"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="540"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI11394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="572" mass="61961" checksum="ADD3106AE430FF3D" modified="2018-11-07" version="1">MASDDNDVEVAALELADDDPLRAMLPAAFGKQDKGPDVTAQLDRSRRTVDKPGDSDRHASSPASDDDDDSDDSDDDDDDGDDFPVSHELVLRTHSRAVTTASLDPSGGRLATASLDCNVNIYDFASMTPSTLRAFKTVDPYESKRSAIDSESHPIHHVEFNQLSAAVVLCVSTHPQAKILSRDGEVLTTFVKGDMYLRDMHNTKGHISEITTGTWHPTDKKLCITAGTDSTLRIWDINNKRSQKDVIVFKTRARGSAGRTKMTAVAWGAAASGGTGVVISAALDGSLVMYGGSGPFTRPAGEISEAHKPQTWTGGIDISSDGRMVVTRGGDDLIKLWDTRKFTKPLVTVAHSSTSDRYPHSNIRYSPNSTSIVTGSATGHLHILNPGNLTPEHVTPVTPDAPLITVNWHPKINQIVTGSANGETHVLYDPALSTRGAVDVMSRAPKKRHIDDNPELTMDQSVGVSGDSIVTPGALAASRRAGTGKSKDRRRPQAPLQTPFQKTQPDEKHVAENIPLARMLHEDPREALLKYADKAQSDPMFTKAWSKTQPKTQYADLSDDEDEGPDKKKAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAG8</accession>
    <name>A0A367LAG8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mitogen-activated protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_7595</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="2"/>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LAG8"/>
    <dbReference type="OrthoDB" id="266718at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004709">
        <property type="term" value="F:MAP kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000196">
        <property type="term" value="P:cell integrity MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000182">
        <property type="entry name" value="MAP kinase kinase kinase mkh1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000387">
        <property type="entry name" value="Serine/threonine-protein kinase STE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050538">
        <property type="entry name" value="MAP_kinase_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016">
        <property type="entry name" value="MAP KINASE KINASE KINASE SSK2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48016:SF48">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE BCK1_SLK1_SSP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="1506"/>
            <end position="1775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="163"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="440"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="515"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="643"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="828"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="933"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1042"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1358"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1444"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="185"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="209"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="356"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="483"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="516"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="882"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="935"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1050"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1098"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1167"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1183"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1200"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1216"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1275"/>
            <end position="1293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1447"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="1535"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI11420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1798" mass="193155" checksum="DC98C846A4D9FE78" modified="2018-11-07" version="1">MERRKQKESDGNLLSGQHQSVSNRRHPKLRGRQHRSEGSFRPVAALRSSIVNCWAYGHLELLTPSQAAESDLSDTRRDSDWQSLIAAANPNLTLAPPFNRGGKRVDDEPSSFISGGTPSPPLFPASPCLPIDAATTRPSSVPALTSEELGVGPTFQPPVMYQGGQRHVSGGGGGGGGGDAMRPFQLPPPPPPISPPMTGGPPLNNIMSIPPPPPPLRYPPAAPSAILPPPPGPPPGLPHGQQSQPWHGNYGRMYDGRSAMAITMGQHQHQPYNPQMHFKRTAGQTLHIPPPPRPSDVMGATYIPNGETYGEGVGIPGFAVDNTLGSWQSHAGSDTNATMPVDDRLVGANQNHSRGHSNASSAAAGSTIPPEVAAQWPLDTVLIWLAQNQFSKDWQETFKGLNLHGAQFLELGSLHGGRGNFGMMHQRVYPRLAQECANSRNGWDQPREREEGKRMRRLIRSIVTGKPVDPSKMTSSHGRKESFTTGHGNSLPSAGTDPTDSPNTEIGYSGRYFGQARSTTLPNPSISSMSSEPNHRLALKHIDGEPGRRLSPIANELAESSPFWEMPVRTDSPAHSPVHQPTLFPSVSVPVPTVSTPPGSTRLGHLSRNSTDSLSSNAATYYGSGVPADAASLLARSLAEGTAGGRHASNNSSIDAADRSSGLEGSGSVKDSKSFRGLFSRMRRPKEDGSFPSPDDYDSPESFVKGHKPASLSYRNGGDGHPFASKSSFTGLDSDEYLSGKRGSAAKTYILATTDHWNYRMCDITAAKTATEIRSTICANLGLADVESASIYATELGQVSHTEPLSDQQILASRRFRSDGPGNLKFFVGPAKSRPDNRVVPASLSPGYLPPGMDEEAYARLNGRRRSSSSPPTSRSNTLLGDKPDEQAQARASEYKAEIERKQREYLAKRQQAKSRDGSTSAEASGVYGIVGRNVDFDQPRNSPFEDKKTDQLFPQRLPPAPPSDPSATLIKANSLSRKPGSSLPTASTTGMSTGGGFGSPRRGLSGADGEGSVKFAAQSPSSGGHIGTLLAGIGRNMGAIGQSSVHAGSSPMSSPVSHPMNNNNNNNNNNNNNNNNGGQQSGKKVLPSVDGRDKDSTSTSTSPKSAGTPGGVTRGRNMSFTVPDYSPGGTPLPPAQHHQHHHHMSSDSAKRPSTGHHRPSTPDDVSPSSRQRARPSNSGGLDSRRKSHGPDLDFEESDVSFSKVRQQTGGHGDEGGDDDGDGDGDGDDDSDDGLFAIPLAGRSKATGGRPSLKVVPPRKNVTIQSPQEMMMVSAESNDGNGSARTGASSRRTPGTPGSEGWDSEDKDGKINRRKSFIEKDIWANRPPTDDLLNNLDDFFPNLDLDQPVLEDGGEMMTPSPITETEETEQTMSAKQPVAASASGPRQPSTYGDGDTLGSDESTLKASEQQRMSAQAVALRGLRRSGGLGRMKSIREVARGAHEANKRLTSASQTVGSKSSTNMMRRKSTKMFNANIVQIRPDQRGSMVLPQIPQDTLPKRQTTFRWFKGQLIGKGTYGRVYLGMNATTGEFLAVKEVEVNAKAAAGDRSKMRELVTALDQEIDTMQHLDHVNIVQYLGCERKEASISIFLEYISGGSIGSCLRKHGKFEESVVSSLTRQTLSGLAYLHREGILHRDLKADNILLDLDGTCKISDFGISKKTDNIYGNDKTNSMQGSVFWMAPEVVRSQGEGYSAKVDIWSLGCVVLEMFAGRRPWSKDEAVGAIYKIANGEIPPIPEDIQETIGPLAVAFMMDCFQVNPFDRPTADVLLSQHPFCELDPNYNFFDTELYTKIKETYKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAN8</accession>
    <name>A0A367LAN8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_7296</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Cytoplasmic vesicle</location>
            <location evidence="6">COPII-coated vesicle membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the VMA21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAN8"/>
    <dbReference type="STRING" id="1330021.A0A367LAN8"/>
    <dbReference type="OrthoDB" id="160405at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03058">
        <property type="entry name" value="VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019013">
        <property type="entry name" value="Vma21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31792">
        <property type="entry name" value="VACUOLAR ATPASE ASSEMBLY INTEGRAL MEMBRANE PROTEIN VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31792:SF3">
        <property type="entry name" value="VACUOLAR ATPASE ASSEMBLY INTEGRAL MEMBRANE PROTEIN VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09446">
        <property type="entry name" value="VMA21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="2 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI11490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="112" mass="12002" checksum="E0EE2783B175943C" modified="2018-11-07" version="1">MFGKEADEPSNITPAVPKHVIVKLLAFSLAMIVLPIGSYFVSVDTIFKGRASLISSFPDSLLTRPLQGNSSYAGAFAALLANVVLIAYVVVAMNEDASDRTAAKKSERKKDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAQ1</accession>
    <name>A0A367LAQ1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein L38e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_7634</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAQ1"/>
    <dbReference type="STRING" id="1330021.A0A367LAQ1"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022618">
        <property type="term" value="P:protein-RNA complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.90:FF:000001">
        <property type="entry name" value="60S ribosomal protein L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002675">
        <property type="entry name" value="Ribosomal_eL38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038464">
        <property type="entry name" value="Ribosomal_eL38_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01781">
        <property type="entry name" value="Ribosomal_L38e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI11493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="77" mass="9006" checksum="7BE562F34B3EFA1D" modified="2018-11-07" version="1">MPREVADIKKARFIEICRRKDASSARIKKNKKSSNVKFKVRCQRHLYTLVLKDTDKAEKLKQSLPPNLHITDLSKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LB14</accession>
    <name>A0A367LB14_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LB14"/>
    <dbReference type="OrthoDB" id="4930473at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI11618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="127" mass="14772" checksum="F9A6950D00E67221" modified="2018-11-07" version="1" fragment="single">TPEPARRREASIAFADRSTVFVPSRKAPNPAYSNSAKTRCKDIRTFSRKKGEFSAFLTNLKDKIRTNKATFRDKENRIGFLFRSLDSKAYKTLETYLLTKTKDDNLSYKDFCGYVKDSVYYRKRDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LB33</accession>
    <name>A0A367LB33_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cupin type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_7657</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the germin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LB33"/>
    <dbReference type="STRING" id="1330021.A0A367LB33"/>
    <dbReference type="OrthoDB" id="1921208at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02241">
        <property type="entry name" value="cupin_OxOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001929">
        <property type="entry name" value="Germin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31238">
        <property type="entry name" value="GERMIN-LIKE PROTEIN SUBFAMILY 3 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00325">
        <property type="entry name" value="GERMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016712819" description="Cupin type-1 domain-containing protein" evidence="6">
        <location>
            <begin position="22"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="7">
        <location>
            <begin position="75"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI11625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="260" mass="27529" checksum="82001CF14A2CB7A4" modified="2018-11-07" version="1">MLLSSTVLLALPALALPSSKAKPDIKATLPPVVPINPRSGNSDLIAKLLTSPTQVDRFALLDQPGDFIFDFNGNSTTSGPRTQGRGGFTLAATSRTMPALIGNGAAMTVGFLGACGMNTPHVHNRATELNIIVQGRLATNFVVENGARPIENLVSRLQMAVFPQGAIHMEFNPDCQDAVFVAGFNDADPGVQQIAQNFFSLRPDVVSATLGGVRTIDGKDIESFRHVIPANVALGIDACLDKCGIKRNAKRSLEQVLGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LB55</accession>
    <name>A0A367LB55_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LCCL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LB55"/>
    <dbReference type="OrthoDB" id="425354at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053037">
        <property type="entry name" value="Pericyclase_pydY-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38115">
        <property type="entry name" value="LIPOCALIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38115:SF1">
        <property type="entry name" value="LIPOCALIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="32615" checksum="45086C688AEC836B" modified="2018-11-07" version="1">MGKSQRPDHSARSFQRPGDRQGQTVASSPSAFLPLVLTSHHSPRDLGCWNMWLVTVPSPEARLSTLEYDDRPAPTRKKDMAAPTSKTIKNLSGQWTMVRHEPRRSVSDSRIRTNGSRSVQQNKTLSDPMEPGLALQGIGFIVRKGICMATISLSVEQYEGTPRPPSTAEGPVWRIDSTQSAAGLSSTSEQRCVDDIRREQTDWLFGTVEGRSHWITLDEVDDAYLARGWIFDGDDKTLLRAIAVNKTAGWTATQVWGFQMVDDERRYCRNVVIEKGEQRVDFRLVYDYVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBG3</accession>
    <name>A0A367LBG3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TATA-binding protein interacting (TIP20) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_7676</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAND family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LBG3"/>
    <dbReference type="OrthoDB" id="6260732at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010265">
        <property type="term" value="P:SCF complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039852">
        <property type="entry name" value="CAND1/CAND2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013932">
        <property type="entry name" value="TATA-bd_TIP120"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12696">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08623">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25782">
        <property type="entry name" value="TPR_CAND1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="TATA-binding protein interacting (TIP20)" evidence="5">
        <location>
            <begin position="1184"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="369"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="479"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="594"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="380"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="505"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI11754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1370" mass="148827" checksum="635791CAB87C3519" modified="2018-11-07" version="1">MASPSLGTASPQVILAHVRKLGDADPDFRFMSLSDLLQLLNNSKPDLLHHDYNVAARTVDSIVKTLDDQNSEVQNLAIKCLGPLVSKVPSSILPPMLDKLSALKFKNSVDSTISSLALRTVITALPRPVPGLPVTVEVKHAYDALQRVLIPRLLGSASETWTADGSLTQYSGDPLLDESTNNAESVDVLIELVRCFGTLLQSVEVEAALRVVMQLLDSKKGTSVVKKRAVVATSMLAAYLSDQQLNDVVQRLTSGLSQENTSPTARRLYISILGSMARSIPSRFGPHLLVATPFVLHALSDGELQKHMAKLSEGDDANQDFNEVREASLVSLEAFLASCPQEMRQFTDDTMTSALRYIKYDPNYAFDGDDDMDVDHGDDANDEDDDDDDDAFDDDAFDDDGFDDDDDDASWKVRRCSVKALYTLIATRGSGDLLDNGVLYSQVAPTLIKRIEEREENVRLEVISAISLLVRKTGEGLHLPDVPLDDLEPEAATQVPLSRKRRRQSSGGSSNVSRFPAGAGLTSPVLDQVPATGPRAELSRLMPSIVRASMKQLQKGKTVATKQSIVNLLDDLVLVQRGGLSDFFSDIIGPVTDETKASTSGAAPPPPSSLAAAGGLASATPSTLRIAALKFISDVCKTHSSSLLQPFLPKMVAAVTSAVHDRFYKISSEAIRTAEELVKTITPPRSRNAGATYKAELEKLYDVVMDRGAATDSDAEVRQRAIHALGVLVSRTLTAEGAELLSAKKRKAALDLLLDRLRNETTRLAAVRAVDNVAALALMPGQLDKGWIQQVALELCAQLRKANRTLRGSSVSALRHLVLCEAARDQLEPSTVEGIALALMPAVTDGDTHLLGPALLILAKMVQSHSQLVMRSDMTAALCQLLKSHFASIVQEQLLELMGAIGRSGTTQQLMKGLLEDVSISGDPSVVGKVIGTLLVTGGDSTGVSVDSFVTELKSSAHSKDDARVSLALAVLGEAGMRLGAESPLEPGLFLEQFHPEPDKVSLAAAIALGRAGSGDAPRFLPVMLKTMKEGGNTQYLLIQSIKEILHSVSVRSTDLRDYALPIWDELIKSCSNADNRVVCAECVGRLVMLDSTVFMPKLETLLRDSSPGIRGMATLLRDSSPGIRGMAVQAVRYTLPESDEAFDAVLQKTLFGMLLVMLQDSDMETRRLAMSTLNSAAHNKPDLMLPHLGKLVPFVLDESVVKPELVKEVMLGPFKHTVDDGLEVRKSAYETLYALMETALSRINIVDLYDRVVAGLKDDNDIRQLCNLMVTKLMTLDPDETTRRLDAIAEAYQSILSHKLKDNAVKQDVEKQDEANKSVLRVSLLLGDRLKAAASSSSWATYWEWVNKEFEKQLRGLREETKELQTRMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBW4</accession>
    <name>A0A367LBW4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000009">
        <property type="protein sequence ID" value="RCI11906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBW4"/>
    <dbReference type="STRING" id="1330021.A0A367LBW4"/>
    <dbReference type="OrthoDB" id="5428925at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14312:SF1">
        <property type="entry name" value="BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTOR A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14312">
        <property type="entry name" value="CREB/ATF BZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="535"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="560" mass="60571" checksum="B19F37917191E781" modified="2018-11-07" version="1">MTPWNGAVSRVRPRSEHKSIRGHISGPMPIPSTGPGDDERPRPATAWRASRQQAELGVMQQPTTARRSKSTLKSAFNRLLGRKKKASSYFTDSGIPPEITAQHHRSDPMGDTRPPKTVESKRSASLPVTEFDRALRSHSISPEDVLAIRSAGSSLNAESRAPSNRAEASDATLALLPCAHSACKSAGLAPRPASSHARHPGLANWSEDPDDIGRAITSDSSGWRRRSRSLSAFPSSDSALISPARRRSHHDVFAWRESCDVRAVTPPTSGSLVDVQKTLAAAPAADKLETTDDDNHFPDFSHEAASLHITEAAGFDLRITDLEARMARLEHVVAELTESLVRFAPPSADLGSGWLHGSVVTPEGKKDGHAHVNMACHPLSHGWDPSKLSHTAYADAIPISDVSRPLSLETVRDKPDKNPIGPADSAETITTDHYLTLVGLLETERSAREMLEAQVRNLGHQFYMASNPTSRPSGGSSAFDLDEDEDDGATAVSRGRTRDDPLAARGDDGQASKGDDDRAVPVSRSTAGMPPSPVQQQQQQQQQQQQQQQQQQQQPLRAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LC16</accession>
    <name>A0A367LC16_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ammonium transporter AmtB-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000008">
        <property type="protein sequence ID" value="RCI11973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LC16"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017016728" description="Ammonium transporter AmtB-like domain-containing protein" evidence="1">
        <location>
            <begin position="49"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="90" mass="9807" checksum="78E9CCC299D1817E" modified="2018-11-07" version="1" fragment="single">TGDWRMGLSRHDEGLQGCDVSRGPPPHQRAFPALFHLILLWTTITLFATDTDVVCTNNHVEATMASTLVGSLAAGLLLPESHNRLCARRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCI0</accession>
    <name>A0A367LCI0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_0710</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCI0"/>
    <dbReference type="STRING" id="1330021.A0A367LCI0"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF40">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="1"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="423"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="443"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI12125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="502" mass="53926" checksum="6CEFBCC95E20EAD5" modified="2018-11-07" version="1">MVRMLVEDVADLGIEPAQHLQATAQHSTAQPPALAGVGVGAISVLVPLYQSEMAPKWVRGTLVCAYQLSITIGLLTASVINILTSPLGDSSAYRIPLGLQIVPALVLTAGLLLLPETPRFLVKKGRDEAAGLSLSRLRRLDMTHPALIEELREMMANHQYELTLGPDTYRDVFVGTPHLGRRTFTGCGLQMLQQLTGINFIMYFSTIFFSRVGVASPHAKSTIINVINVVSTIPGLLVIESWGRRRLLMVGALGMAVCQLLMASFSTAAAGRVDLAHVSQTMVVVFCSFNIFFFAASWGPVVWVVTSEIYPLKVRAKAMSLSTASNWMLNFAIAYSTPVMVVGDAGFGAKIFFIWGAFCIIALLFVWCMVYETSKMSLEQIDEMYERVGHAWDSTSFEPSWSFQQLVDDQGWATGAAAAAASSHELQSTPTHSSADTAVGGQSSSSSSSSSSSSSMTMREGERGRSRSSGGGGDGAQVAIVTTTTTEEDKSLPAMAAVDFSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCI4</accession>
    <name>A0A367LCI4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Serine/threonine-protein kinase SSN3</fullName>
            <ecNumber evidence="4">2.7.11.22</ecNumber>
            <ecNumber evidence="3">2.7.11.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Cyclin-dependent kinase 8</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Serine/threonine-protein kinase ssn3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">L249_1098</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="4"/>
    <dbReference type="EC" id="2.7.11.23" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCI4"/>
    <dbReference type="STRING" id="1330021.A0A367LCI4"/>
    <dbReference type="OrthoDB" id="6284126at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000408">
        <property type="entry name" value="Serine/threonine-protein kinase SSN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF495">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0010">Activator</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="15" id="KW-0804">Transcription</keyword>
    <keyword evidence="13" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="24">
        <location>
            <begin position="48"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="328"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="468"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="23">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="23">
        <location>
            <begin position="328"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="23">
        <location>
            <begin position="353"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="364"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00039418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00040708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00041823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="RCI12139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="537" mass="59945" checksum="B9C5A3A5B15FE30C" modified="2018-11-07" version="1">MPLRRRNGGHAPHHKAPPFSSSSAHTVSSDNHDRPSGFQPRARVMDRYRIVGFISSGTYGRVYKAVSRPSAGPPPQAVASDGAPVSSEVAIKKFKPDKEGEQISYTGISQSAIREMSLCSELRHANVIRLVEILLEDKCIFMVFEYAEHDLLQIIHHHTQQPRHPIPPATVKSIMFQLLNGCQYLHTNWVLHRDLKPANIMVTSAGEVKIGDLGLARRFDKPLHSLFSGDKVVVTIWYRAPELILGAFHYTPAIDMWAVGCIFAELLSLRPIFKGEEAKMDSKKTVPFQRNQMQKIVDIMGMPTRERWPLLPTMPEFSQLSILQAPATHHHLQHHHHHHHHQQQQQQQQQQHYHGHHHQHHHAQSGPASSSSSSQRASAPGSLLEKWYYNTISNAGLGSGSSSSSSSAAPSLTSLGPEGYRLLAGLLEYDPIRRLTAAQALQSSFFNTGDRVSANAFEGLKVEYPHRRVSQDDNDIRTSSLPGTKRNGLPDDSLLRPPKRMKDSAPIEALQRERRAQTLMKLGALVLPRVRFAGISG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCS2</accession>
    <name>A0A367LCS2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rhodanese domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_1352</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCS2"/>
    <dbReference type="STRING" id="1330021.A0A367LCS2"/>
    <dbReference type="OrthoDB" id="270167at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01448">
        <property type="entry name" value="TST_Repeat_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01449">
        <property type="entry name" value="TST_Repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000001">
        <property type="entry name" value="Sulfurtransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000033">
        <property type="entry name" value="Thiosulfate sulfurtransferase TUM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045078">
        <property type="entry name" value="TST/MPST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364:SF27">
        <property type="entry name" value="SULFURTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11364">
        <property type="entry name" value="THIOSULFATE SULFERTANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="65"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="4">
        <location>
            <begin position="209"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI12215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="333" mass="37009" checksum="1E79C49D44B36258" modified="2018-11-07" version="1">MASVIVCRAPRVAVAARAFKQLLSSRRNLSSYLVTPKELHEALRKNPPSTINPDPRVVPLCAAWFMPSDKRTGIEAFREQRIPRARFFDLDKVIDKRSPYPHMLPDAKGFAAAMSELGIRKEDTVVVYDTKELGIFSAPRVGWTLKVFGHKNVHILNNFKLWVEQELPTESGELYSVECCPYPIPTLDAAKVASFDDVKEVAQDHNKEGAEGIQVLDARSPGRFRGTDPEPREGLSSGHIPGSINVPFTAVLDPETKAYPSADQLRSVFKQLEVDSEKPIISTCGTGVTACVVETALDVAGYGTPESRRVYDGSWTEWAQRVQLSDNLIWKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCW8</accession>
    <name>A0A367LCW8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gag1-like clamp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_0007</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCW8"/>
    <dbReference type="STRING" id="1330021.A0A367LCW8"/>
    <dbReference type="OrthoDB" id="5422958at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053274">
        <property type="entry name" value="Fluconazole_resistance"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025124">
        <property type="entry name" value="Gag1-like_clamp"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28065:SF1">
        <property type="entry name" value="DUF4050 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28065">
        <property type="entry name" value="FREQUENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13259">
        <property type="entry name" value="clamp_Gag1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gag1-like clamp" evidence="2">
        <location>
            <begin position="217"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="262"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="290"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI12266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="484" mass="53146" checksum="1159D3277BAD6361" modified="2018-11-07" version="1">MSRQRSDVSYPAFVLNGTSASLPASSTSSKFAMIFSDFYKSPRSPLAKLLHSNSQPLAQSHTATPDWATAEYADLLSRDKTRQKEAIRRYLYDKVRSDWEFNWPQQPPGQSSPITEGPAASGSGRQSTDNAVQVQDETRDDAGYQVDAGSPLEEPPSQPELEDEEEDDDDARSTYSIVSEDAIHYRPRIESTSDLSDDEPSSPARISITEPLRLASKTRDMERKARRRRALREEMTWNDGLACFEARRNAWTGARTVRVRSKPISPSSTSPKSPRRFLLRHSMSGSPPTSANSVAVQSANASTNLSEASSLVRDTDRELNKHQTRESTTSDPASTEAFPVETLVPVGLPLLPPSNSMRATITPAVYSNLYDKVVLNNVQPSCPINLSDMLRSCVAGWKRDGEWPPRPAVPDPTVSVRRSKKASSAGGDCSGSVAHRMSFGLLSRDKDDDGRTSKGFRRSLQKAFGLGVGTGNGEFLEGGTMKER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LD19</accession>
    <name>A0A367LD19_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">XPG N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">L249_1314</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Single-stranded DNA endonuclease involved in excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents. Essential for the incision step of excision-repair.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the XPG/RAD2 endonuclease family. GEN subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LD19"/>
    <dbReference type="STRING" id="1330021.A0A367LD19"/>
    <dbReference type="OrthoDB" id="31113at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048256">
        <property type="term" value="F:flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09904">
        <property type="entry name" value="H3TH_XPG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09868">
        <property type="entry name" value="PIN_XPG_RAD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000025">
        <property type="entry name" value="DNA repair protein RAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000030">
        <property type="entry name" value="Flap endonuclease GEN-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000061">
        <property type="entry name" value="Single-stranded DNA endonuclease (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001044">
        <property type="entry name" value="XPG/Rad2_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-G CELLS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171:SF7">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00066">
        <property type="entry name" value="XRODRMPGMNTG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="17">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="16">
        <location>
            <begin position="865"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="343"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="472"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="570"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1128"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="821"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="358"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="395"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="411"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="474"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="502"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="517"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="618"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="644"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="655"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="739"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="778"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="1139"/>
            <end position="1149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RCI12307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1149" mass="128891" checksum="7DB73E1CBC6BBC09" modified="2018-11-07" version="1">MGVNGLWTIIQPCARPTNLATLNRKRLAVDASIWIYQFLKAVRDKEGNALRNSHIVGFFRRICKLLWYGILPVFVFDGGAPALKRATLQKRQRRREGRREDAVRTAGKLLAVQMQRAAADEEERRKREQQSGNVSAREARLQEEDAADANVLVYQAELTMSQQDKAQSRRFHKQDAYHLPELNRDIASMGKPEDPRIMSVEELDEYARQFQNGEDINLYDFSKIDFDSDFFKSLPAADRYNILNTARLRSRLRMGYSKDQLEDMFPDRMAFSRFQIERVRERNHLTQRLMQEVGMLGTDLTLPINARVAGEKDREYILVKNEGAEGGWALGVVSREKDVGEAHKPIDVDAIQVRYESKDDEEEEDDDDDDDFEDVPIAGFNRLPKLKPSEAAGWQTAQDPAEQGQQLQPDHQGRAAGDKEESLFVGGNTGETSVILQELAEKQTSLVDEDELNEAIALSLKSQVELDQEQAEVSLDKPKWKQRAVEASRPIQGNSGSMIAHVVNNRANAAVSRRQEGEDDESDSDDDVRAIVARSMRAKPAEAKRGIDNTFGGPLPFPKLDWKSSVFAKKATHEEAEPESNVPKEAQAVDDEDGGFEVSAHEEDDQPKALPPWLVDDTDIRESLKKQHNVDKEINAEDREEAEEERRLQRREMQRQLIEIDSSSSDGDSDVEIIEAPPSATQPAGDEAVTVDDGPQPVRDTSTEEPEDAGHASGVDSQTYTLPCADGIIPPEEEPLSAEQKQSSASTSPEPEFEDVPTLTVTRNDPSLGRDATRTETQESDDDLFGDAESEDYSEPEDEELMMQMAEEAEEHARFASQLNQKSAAQNREEYEKELRALRNQQKKDRRDADEVTQVMVGECQALLRLFGIPYITAPMEAEAQCAELVRLKIVDGIVTDDSDTFLFGGTRVYKNMFNSNKFVECYLGVDLEKEMSLSREQLISLAQLLGSDYTEGLPGVGPVTAVEILSEFPGKGGLEEFRQWWTAVQSLNRPKEADASSTFRVKFRKSQATKLFLPPGFPNAAVSDAYHHPEVDDSAEAFQWGVPDLEGLRRFLMSTIGWSQERTDEVLVPVIRDMNKREVEGTQSNITHFFGGGVGAGAKEAFAPRQRARGSKRMAAAVDKLRANVSGVGVGGEEERPRKRRRRRARKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LD21</accession>
    <name>A0A367LD21_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleolar protein 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">Pumilio domain-containing protein NOP9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_0068</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LD21"/>
    <dbReference type="STRING" id="1330021.A0A367LD21"/>
    <dbReference type="OrthoDB" id="392571at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040000">
        <property type="entry name" value="NOP9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22493">
        <property type="entry name" value="PUF_NOP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="469"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI12316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="674" mass="74334" checksum="9768796E24B0C728" modified="2018-11-07" version="1">MPKQRTKRTTVREERKRKHQEQTKERNPKRPRTTGPQEDDDDDKKAVFFFGMLSDEEQEYFRSADEMLELNQFPSVEDRDLFIENVYREARGKELKLASSQSCSRLMERLIQLSTTRQKKHLFAAWAGHFLALVQHRFASHCCEALFLRSAGIVTRDMAGFVIDLKGVAAKNQEAEASMESLFLATLDELEGNFSYLVVDRFASHALRALLLVLSGRPLEEASARSLVKSRKKENVWVAGSAAADEVNKGHRAVPASFIAAVDKIIADSTAGLDASGLALLARHPIGNPTLQVLLTLDMARDKSEAKSDDVRPKSLLLRLLPGAPASLADASSEASQLVAGLMYDRIGSRLIETVVAHCPGKIFKPLNHNIFLPRIEAFVRNDISSYPAIKVLARLSKDDLVEAVNKIAPTVPQLVAKSRFNVLKTLFERCAVRVASSETKQLMKGLREGCGSEPADLIVTLCCLRSGDDDDDDDEDEKTKRRKKATDKPDGNEYAIQSHGAQLLSALLAIPGPAKGVHEALSAVGTDTLLRLAKTSMPTVTLLTDALSTPSANSSFQKTLVGAMTNHVSDLASSQFGHNLVKAVIGIPSKGKKDVSVPLHMKEVIMQRLGACESQLRESWTGRTVWRSWRGDLWKRRPGDWKAWARELVALAVDGGGLGRVAEKRHEAVKRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LD71</accession>
    <name>A0A367LD71_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_0149</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LD71"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI12374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="163" mass="18206" checksum="FA155821C73C8CB3" modified="2018-11-07" version="1" fragment="single">RSSSDSYNAPPNPFLITLSDLRLSYLSQAGLLRLRTLRFNAFAALSPLNNYAKAISRIYFIAVDIESFRLNSRSSPLRSNPPIRLPRSSPNTPITGRRVDSVCLRCGVPGYYSNKCSLRPACRPPKLSIRFVDTVEDSDADLESAGKRPFELEPYAVGRVLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDK6</accession>
    <name>A0A367LDK6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="12">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_0603</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 12">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 12">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 12">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="12"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDK6"/>
    <dbReference type="STRING" id="1330021.A0A367LDK6"/>
    <dbReference type="OrthoDB" id="10265628at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000097">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF57">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 12" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9 12" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="13">
        <location>
            <begin position="65"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI12504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="527" mass="57623" checksum="308C6D55D3F644ED" modified="2018-11-07" version="1">MSPATPVLRGTTRALRRVAMLTPKAAKSSMALDGQQQLLAAHLQRADAAVFDIIENRIGEEALLNITQEKRRQKHFINLIPSENFTSQAVLDALGSVMQNKYSEGYPGARYYGGNEFIDESERLCQRRALEAFDLDPKKWGVNVQALSGAPANLYVFSALMNTHDRLMGLDLTHGGHLSHGYQTPTKKISFISKYFETLPYRLDESTGLIDYDMLEKLAVLYRPKIIVAGASAYSRLIDYQRMRDICDKVNAYLLADMAHISGLVAAKVLPSPFPHADIVTTTSHKSLRGPRGALIFYRTGVRRQNPKTKQDELYDLAGPINASVFPGHQGGPHNHTIAALAVALKQAQSADFHAYQLQVLANAKAFAKRLGDAKGKGGLGYSLVSGGTDNHLVLTDLKPNGIDGGRVERVLELVGVAANKNTVPGDRSALVPGGLRMGTPAMTTRGFNEDDFVRVADVVDRAVAIACRLDKTVRAAAKERGEKSPGKLGLFLEHLDNGDNEPEIVQLRSEVEDWVGTYPLPWDSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDN1</accession>
    <name>A0A367LDN1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDN1"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016612392" evidence="1">
        <location>
            <begin position="19"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="153" mass="17890" checksum="08D4C17ADF68CBF2" modified="2018-11-07" version="1">MFFCYILYFVLPCSVIITYTYDTTDREYEIYQNRCESTDDKLCCHHLRGRSRREPRRLRVVIQCKQACVEQLANIHGLNQGLLGTADFNGSRISVRLRLQQKDNFPTQTTGDTLSNSTKHPSVYEDDVYAGWHRPVKVRDVRILSVYRCHPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDP0</accession>
    <name>A0A367LDP0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDP0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="108" mass="11761" checksum="7C787B0DCE4684DE" modified="2018-11-07" version="1">MTCNKNRSKLHKRQWPNSPSKRTLPSISSELLTRGRARLGTVSSAVILAASLPTRQSTLSTFTSDTAPSSSSRRSDGTATNRVMARVGIMMARPLGGCCCCCWWTRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LE07</accession>
    <name>A0A367LE07_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LE07"/>
    <dbReference type="STRING" id="1330021.A0A367LE07"/>
    <dbReference type="OrthoDB" id="61390at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="39127" checksum="D752227D1D67B00A" modified="2018-11-07" version="1">MVWTLSARDFVMGIVVGVVGSALLAGAVAFTVLRASAAYSLGHWKLNLKTPLDTMWMNLGFWRDEDGKPVLRFDEACLGLLREMLKSAGLLDRGSDAGPVSVLDLGFGCGDQTLALARLLEPKSSHLFRYVGLTLNRSQLRTAERRIRRELASPPRGATSLALTLECFQLFCADAAKPASWSTDVRDAVLGLGGGGGGGATFGHRWLLALDCLYHFSPSRKPVFRFAAGRLDANLAAFDLILNSQASWRDTLLVRLVGLLMSCPLRTFLTEDRYRADMVECGYDPKSITIRDVSDDVFAGVADYLERQEEALSLYGISIAGFKLAGRLFGWFDRSRVVKAVIVVGRTTSGQPLTPLTGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LE31</accession>
    <name>A0A367LE31_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_0418</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LE31"/>
    <dbReference type="STRING" id="1330021.A0A367LE31"/>
    <dbReference type="OrthoDB" id="276276at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02883">
        <property type="entry name" value="NUDIX_Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020476">
        <property type="entry name" value="Nudix_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43736">
        <property type="entry name" value="ADP-RIBOSE PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43736:SF1">
        <property type="entry name" value="DIHYDRONEOPTERIN TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00502">
        <property type="entry name" value="NUDIXFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="2">
        <location>
            <begin position="36"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI12492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="187" mass="21003" checksum="41FA91685EA2C86A" modified="2018-11-07" version="1">MPAPFTIDDGIPSLTECNVPARTWLSNNINRHHPRLSGLATSTFVFNPSGRLLVLQRASDDSSPNLWEAPGGAVDEGDATVLEAAARELREESGLVVSRFRRCFPGVDVFPNRDRSRFFARLAFLVDVESCLVVRLDAREHQAFAWASEEDVRCQTLDGHPLPITGREMRRLLLEAFRLRRELETSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEA0</accession>
    <name>A0A367LEA0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Subtilisin-like protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_0521</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEA0"/>
    <dbReference type="STRING" id="1330021.A0A367LEA0"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000014">
        <property type="entry name" value="Proteinase K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF58">
        <property type="entry name" value="ALKALINE PROTEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016942224" evidence="8">
        <location>
            <begin position="21"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="10">
        <location>
            <begin position="38"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="9">
        <location>
            <begin position="170"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI12748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="421" mass="45355" checksum="C021FC7ABCF3ABFC" modified="2018-11-07" version="1">MISWNILLAALTTLWSYAGAAPMSLANGPPGSTIQGHYLIALKPGSKPHDLHSHLNWVEGVHKRGLSPEQFRGVERTYSDRANFHGYAGHFDKNTIEEIRKNPDVAVVEEDRIWELDYLESRHDMTVTQESNSLEKRTFSTQTDSPWGLGAVSHRRKGATEYIYNERAGQGTFAYVIDSGIRLSHQEFEGRAKSVFTAFPNETTDSFGHGTHVAGTIGGKTYGVAKKAELLAVKVFQGRRSATSVILAGLNWATNDIVDRRRTRSAVINMSLGGSYSNLMNLAVESAAQQGVVAVVAAGNEAMDAAFVSPASAPSAITVAAIDGNWTLAEYSNYGKAVDIFGPGTKITSSWIGGDGDNKTISGTSMATPHVVGLALSAISVEHVRGLDELTKYLKDTATEGQITGNIYGSPNLMGYNNIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEZ2</accession>
    <name>A0A367LEZ2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">DNA 5'-3' helicase</fullName>
            <ecNumber evidence="19">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">L249_0013</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family. RAD3/XPD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="19"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEZ2"/>
    <dbReference type="STRING" id="1330021.A0A367LEZ2"/>
    <dbReference type="OrthoDB" id="272481at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045951">
        <property type="term" value="P:positive regulation of mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.40:FF:000001">
        <property type="entry name" value="DNA repair helicase (Rad3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.20:FF:000001">
        <property type="entry name" value="DNA repair helicase rad15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000135">
        <property type="entry name" value="DNA repair helicase RAD3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000128">
        <property type="entry name" value="Putative DNA repair helicase RAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000381">
        <property type="entry name" value="TFIIH basal transcription factor complex helicase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.20">
        <property type="entry name" value="Bacterial XPD DNA helicase, FeS cluster domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010643">
        <property type="entry name" value="HBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001945">
        <property type="entry name" value="RAD3/XPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042493">
        <property type="entry name" value="XPD_DNA_FeS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06777">
        <property type="entry name" value="HBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00852">
        <property type="entry name" value="XRODRMPGMNTD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="21" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="17" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0804">Transcription</keyword>
    <keyword evidence="13" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="22">
        <location>
            <begin position="1"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="21">
        <location>
            <begin position="231"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="RCI12993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="770" mass="88420" checksum="40239553EB3273E7" modified="2018-11-07" version="1">MCDLKKTLDAGGHCVLEMPSGTGKTVSLLSLIVAYQQNMPERRKLIYCSRTMSEIEKALVELKELIKYRAEQLGYEEDFRGLGLTSRKNLCLHPSVKREKSGSIVDARCRSLTAGFVKEKKEKGENVKVCIYHDNLDLLEPHNLIPNGVWTFDGILRYGEEHKQCPYFTARRMMQYCNVVIFSYHYLLDPKIAERVSRDFSKDCIVVFDEAHNIDNVCIESLSTDITEDSLRKASRGAQNLERKIAEMRNTDQEQLQNEYQKLVQGLRDADEARQEDAFMSNPALPEDLLKEAVPGNIRRAEHFVTFLKRFIEYLKTRMKVRQVISETPPSFLGHLKEHTFIERKPLRFCAERLTSLVRTLELTNIEDYHPLQEVATFATLVATYEKGFLLILEPYESDTAEVPNPIFHFTCLDAAIAIRPVFERFYSVIITSGTISPLEMYPKMLDFSTVIQESYSMTLARRSFLPMIVTRGSDQASVSTSFQVRNEPSVVRNYGTLLTEFAKITSDGVVVFFPSYLYMESIISMWQGMGILDEVWKHKLILVETPDAQETSLALETYRTACCNGRGAILLCVARGKVSEGIDFDHQYGRTVLCIGVPFQYTESRILKARLEFLREKYRIRENDFLSFDAMRHAAQCLGRVLRGKDDYGIMVLADRRFQKKRAQLPKWINQGLLEADVNMSTDMAVASARKFLRTMAQPFRAKDQEGISTWGPEDLRRHEEKMELDKRLDEEEAIRDPTVKNISAVDGFDIDIDDAAFDEEMMDMEDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFB5</accession>
    <name>A0A367LFB5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Calcofluor white hypersensitive protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_0053</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFB5"/>
    <dbReference type="STRING" id="1330021.A0A367LFB5"/>
    <dbReference type="OrthoDB" id="68581at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000031">
        <property type="entry name" value="Calcofluor white hypersensitive protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057315">
        <property type="entry name" value="Exo_endo_phos_PGAP2IP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051916">
        <property type="entry name" value="GPI-anchor_lipid_remodeler"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053912">
        <property type="entry name" value="PGAP2IP_TM_1nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053911">
        <property type="entry name" value="PGAP2IP_TM_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14859">
        <property type="entry name" value="CALCOFLUOR WHITE HYPERSENSITIVE PROTEIN PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14859:SF1">
        <property type="entry name" value="PGAP2-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23022">
        <property type="entry name" value="6TM_1st_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23021">
        <property type="entry name" value="6TM_2nd_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23226">
        <property type="entry name" value="Exo_endo_phos_PGAP2IP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="322"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="375"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="398"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="443"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="530"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="563"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="598"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="636"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="2">
        <location>
            <begin position="19"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="PGAP2IP first transmembrane" evidence="4">
        <location>
            <begin position="269"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="PGAP2IP second transmembrane" evidence="3">
        <location>
            <begin position="441"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="PGAP2IP C-terminal nuclease-like" evidence="5">
        <location>
            <begin position="669"/>
            <end position="916"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI13119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="946" mass="105462" checksum="3F1B069F8F1F4BC4" modified="2018-11-07" version="1">MASRYKDKDAGVVVSFGGQWVSWAHTAIAFAAFLSALVVGLALHYHKIVQNEFYGYPDEWFPSVSAAIGDRYPERSIFMIFIAVTSGPRFALVGLWYLLTRRHGSRLPAFVASMGFIRTLTCGGWTYITSTDDHDWHDILMISYIVATLPWTTGCIALSPPNSQAIKYRKYLASAFFGTLVPLIYFFIRHKVHRVAGAYTIYAFFEWSLIFFDVAFDAVTALDFNTFEVSVKDVRGSTKGKRKATADVYSLNFTWSEALDIAASVYHGFIFWSMLTSLGVLVWYFPLWHMGISGYEAFVLVSASPALLVGPARSLVVNNARAIHLLSLIGIAAYLVLDPARRLFTVGLAVALSTLGWVATLHSESAHERRFESRLLGLMIGLILSSTIKFAWQTNNPVWPILHAANGGWNATGLVVGVLAALRFTRHAPLTGGLSQGGRKGGSAILAACGIGGLFFGLHSLLSDTSTMILWVWEGFPIRGPYHSTHGWCTVAAMSAGLCAGIWRPNLAGSWTQFAAGALGAMVLTKFSHWLGYLGGLGLAVYLMAVSVPLISNASKRTPAVTFGLGFFIYVFMVLFHVWVVAYAFVPGGPLVREHTDWVMTIMMALIGAGVADFNSSLPQRQQPYSSTRASQHRRYYGVATLLVNIIFLCAAFMRFPRTDHKPYHAEDRVLTAGIWTVHFSLDNDMWSSEYRMRDLLKELELDVVGLLETDLQRIIMGNRDTTQFLAEDLGMYVDYGPGPNKHTWGAALLSKFPIVESKHHLLPSPVGELAPAIHATLDVYGELVDVFVFHSGQEEDAEDRRLQSEYLSNLMGSTSRPSVLLSYLVTKPLEGNYNTYVSNKSGMHDIDQTDWDRWCEYILYKGLQRVGYARVSRSTITDTELQVGKFVIPRSAAEVKQLEARSAEERDRRVEESEVPEGWRFPALFRGKGVRNHRYHVFDEPRYFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFC3</accession>
    <name>A0A367LFC3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C-CAP/cofactor C-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_0058</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TBCC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFC3"/>
    <dbReference type="STRING" id="1330021.A0A367LFC3"/>
    <dbReference type="OrthoDB" id="70250at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1250">
        <property type="entry name" value="Tubulin Binding Cofactor C, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007720">
        <property type="entry name" value="PigQ/GPI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038397">
        <property type="entry name" value="TBCC_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012945">
        <property type="entry name" value="Tubulin-bd_cofactor_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329:SF3">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05024">
        <property type="entry name" value="Gpi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07986">
        <property type="entry name" value="TBCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="513"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="590"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="620"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="4">
        <location>
            <begin position="930"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="873"/>
            <end position="893"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI13120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1132" mass="127230" checksum="2EBEA7474164F40B" modified="2018-11-07" version="1">MKQSRLGPPPSSLRTSSIYTNCQVYAPRRAIPSSPSPSGERNSSLTCARFPPPEACAAGEAKRSSMHPFSILTLGIFVAGYITARWDLVTRLYELAIFAAENGVVAQDVEFHLRLGSFFRGGPHNPCRIYDVCGHASMHVLGVSNAPHSDTADPSWVRATTKPPLKQPTIECAKASSVQVILYDRPKPRRMQYISLEPIALALSDKTSRLEDANPDDEIEQQELKAKETKRKLVEKLKLHTITRRVPSARDRALPKIVNQVNWSWELEQTLQKNVGRLGPRPRRSLSVSERVVESATTMRNYVLRWLWALFTTYLFPVIWRCFCLVLFGHRMVAEVLLLALEFRAKPGGAALKDISATAQQIEIRLQQFCYWPMQYSTLRQRKMNWASVTTSHPDYIRFYNSLWLVANDVIIGMALGSYIIEHADWMASRMGDILRTYAVEALRRSISWLMGWPAGLKLNGELAAFLGDLFLWVIHYWSSKPYSLLKRVANSADGDGLGAGCIEALEPMLPRLVWFIGFSSFAGASMPIAVFSDLLSALTMHIYSFYLASARIYHWQLTILQSLFHLFRGKKHNVLRNRIDSCDYDLDQLLVGTIFFTLLSFLLPTVVVFYLNFAVARMIIISIKAGFDTLLSCLNHFPLFALMLRVKDPRRLPGGIRFELRDGPEQKASDSNEPPTSVIYLKSIPLSMGAMFNQYFQMAHRIRKHYLSPGVLLRLLTGQFVPPINRKNLYSLQYSMLPAKRATAWEMWRALNMEPQKKKSFQLPLIPHFQENVAVLEDQIDQLESVSAVAGERQEAIDHVLAGIAQVQIQVSDAADYTPSYERRQYAEVCDARLKFYFEQIVKSLHDKLNETVTRVTPKSRFQFKRSVDDTAHVDMGAPENDPRLNPGSLSRNSQPMTFENAVEEADDTIGHLPSSPTGRDYNQELSQPGVPGIRKPSFSTAKNIGISHQMGLHVILPSSAARATASGSLTNLHSCIVDMSVPTVQGRPFPGLSLKSIRNSLIVTGRVSGPVHITDVTDSILVVVARQVRIHDSSNVDVYLHCSSHPIIEDCSGMRFAPLPQCYMTEVESTTDNQWDQVDDFKWLKAGHSPNWTTLSEAQALGDEVWTKVVPGMPGASVEETLNKVGLPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGZ2</accession>
    <name>A0A367LGZ2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_7976</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGZ2"/>
    <dbReference type="STRING" id="1330021.A0A367LGZ2"/>
    <dbReference type="OrthoDB" id="6428174at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF85">
        <property type="entry name" value="DUF803 DOMAIN MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G15880)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="378"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI13681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="45215" checksum="8976DEAC9CF24B2F" modified="2018-11-07" version="1">MIEDKYIGLALAMSSALAIGTSFVITKKGLLDAEQRHGFEGDGFVYLRSPVWWAGIATLVIGEVCNFAAYAFAPAILVTPLGALSVLIGAVLGSYFLEEELGTLGKLGSAICLIGAVVIVLHAPPDEDIQTVDQILHFAIQPGKAPVLQRALKYRLTSPIGFLLYSLAVIAFAVFMIYKIAPAYGKKNALIYLSICSTVGSISVMSVKAFGIALKLSLAGNNQFSHPSTYVFMILTTVCILIQMNYFNKALASFPTNIVNPLYYVTFTTATLCASFILFSGFNTTDAVNTLSLLCGFLVTFTGVYLLNLSRGDPNAQIVPAGHMGSDSTPTDMVSSLQTRRSMQARRSGDLVRHSVSSLHGDREGLIRAYDEEEAAGFGLTDLAEESEDDSRQPSSRINGKKEVNSDDIELEDRKSAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHF0</accession>
    <name>A0A367LHF0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Large ribosomal subunit protein mL67</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_8000</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL67 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHF0"/>
    <dbReference type="STRING" id="1330021.A0A367LHF0"/>
    <dbReference type="OrthoDB" id="5333655at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024629">
        <property type="entry name" value="Ribosomal_mL67"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28184:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28184">
        <property type="entry name" value="MITOCHONDRIAL HOMOLOGOUS RECOMBINATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12829">
        <property type="entry name" value="Mhr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI13817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="337" mass="38367" checksum="1049C9629EA51799" modified="2018-11-07" version="1">MNIALEARSRLFFNLALRRPQAFVRASSTDAAPLSERQRRKAKHGEEVWVFACRKTRQVVFSFERKLSRHHVNKQLPFVGKKSKPENMRKDLWSPFLRITVPEGLGHVGRAIFKQLREFKHLHEVSWDGDLIFKTPSEYTEEERRRMKQYPRGPKPQRPRKQRAASINDMVGNVVADLATILAGTPKGGAMTITQLKMTPDRHANAIGKAQLNLRQVENKVKARLHKKAKELVHEEDELGGLTTDSETTAEKTVTAYAKLIHDAKLAIPEEAIFQLCPVTVSWVDEQNKEYAEKWSSNVTHEALELNLCRDVERLSHGPEIKDEASVEAEIKAEAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHP2</accession>
    <name>A0A367LHP2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Monopolin complex subunit Csm1/Pcs1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_8117</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHP2"/>
    <dbReference type="STRING" id="1330021.A0A367LHP2"/>
    <dbReference type="OrthoDB" id="2431049at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034506">
        <property type="term" value="C:chromosome, centromeric core domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033551">
        <property type="term" value="C:monopolin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990644">
        <property type="term" value="F:microtubule site clamp"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045144">
        <property type="term" value="P:meiotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23787">
        <property type="entry name" value="RWD_CSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.80:FF:000001">
        <property type="entry name" value="Chromosome segregation protein (Pcs1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040349">
        <property type="entry name" value="Csm1/Pcs1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020981">
        <property type="entry name" value="Csm1/Pcs1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038608">
        <property type="entry name" value="Csm1/Pcs1_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28006">
        <property type="entry name" value="MONOPOLIN COMPLEX SUBUNIT CSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28006:SF1">
        <property type="entry name" value="MONOPOLIN COMPLEX SUBUNIT CSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12539">
        <property type="entry name" value="Csm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Monopolin complex subunit Csm1/Pcs1 C-terminal" evidence="3">
        <location>
            <begin position="320"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="246"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI13956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="425" mass="46510" checksum="07D9B964A0317906" modified="2018-11-07" version="1">MVSRAKEAGASSSLVRYDLDSGTDDVTSTQAEAKPRTRRKARGRPPGIGNRVDKSTPRATRTTGKHIAATCSSSRKHAVSSLSQGLQRSVDAVAHDTGGYDTVKRTRGRPNATGSDKVAASTSFTKRSAAEEIPETQSTAVLRIKHDTADSSAMDELSMAEADISLVVDGPAASDVFSRRRLGELNKRHENLKIRHRDLRDVGIKSAEVNFDRLKKQAEGNIAVSNHLILQLQEDLAAQTALAEQGESLRQQLERSEANAESLQAAVDKLTADLNAARQEISALSVKLTVNRNAENSVQKPTIKFNAVVDKSELIHTAHAKEDLYGDLTGLIVRGLSQGEDEDIFDCIQTGRNGTLHFKLASERRSPSESYDDVQLTYRPQLDESRDQGLIQLLPDYLVEDITFSRSHASKFYHRVIRSLSEGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHX5</accession>
    <name>A0A367LHX5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Poly(A) polymerase</fullName>
            <ecNumber evidence="13">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">L249_7903</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Polymerase that creates the 3'-poly(A) tail of mRNA's.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 2 magnesium ions. Also active with manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="13"/>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHX5"/>
    <dbReference type="STRING" id="1330021.A0A367LHX5"/>
    <dbReference type="OrthoDB" id="412748at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.590:FF:000003">
        <property type="entry name" value="Poly(A) polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000002">
        <property type="entry name" value="Poly(A) polymerase alpha, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000001">
        <property type="entry name" value="Putative poly(A) polymerase gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.590">
        <property type="entry name" value="Poly(A) polymerase predicted RNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048840">
        <property type="entry name" value="PolA_pol_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007010">
        <property type="entry name" value="PolA_pol_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014492">
        <property type="entry name" value="PolyA_polymerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF10">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20750">
        <property type="entry name" value="PAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04926">
        <property type="entry name" value="PAP_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018425">
        <property type="entry name" value="PolyA_polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="PAP/Archaeal CCA-adding enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="632"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase nucleotidyltransferase" evidence="20">
        <location>
            <begin position="8"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase central" evidence="19">
        <location>
            <begin position="211"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase RNA-binding" evidence="18">
        <location>
            <begin position="358"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="530"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="540"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="101"/>
            <end position="103"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="158"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="238"/>
            <end position="239"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR018425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF20750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RCI13852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="666" mass="74402" checksum="7B186BD4B9163677" modified="2018-11-07" version="1">MPGEHGFGVTPPISETLPTDAEKRSSDALIEELRRQKTFENPSDTEKRFKVLESLQSICDEFVKRVAKEKEPKNEMLIKNARGKVFTYGSFRLGVFGPGSDIDTLIVAPKYVTRDDYFKLFPDMLVEMAPKGAITGLTVVTEAFVPIIKFEYSGISIDLIFSRVVQKQLSASFQDLKDSALLRGLDEAELRSLNGTRVTDEILNLVPEPSTFKLALRAIKLWAQRRAVYANIMGFPGGVAWAMLVARVCQLYPKAATSVIVNKFFLVIGQWRWPQPVLLKPIESGPLPVRVWNPKVYKGDSFHLMPVITPAYPSMCATFNITRSSMTIINAELQRGLELTENIMVGKSPWSDLFIKHTFFTADYRYYISVISASKDKEAHKIWSGYVESKVRMLVQKLELHPSIALAHAFNKGYDRRHRCKDDKEIAQVQEGSLDFMVRPDDVNSEADPTPQAEKGDDAEPGSLTEVFTTTHYIGIRLVEKAKSLDLSFQVDEFKGLCTQWKKFQEELRTLVSIGVQHVRNVNLPDDVFEAGEKKPEKKGVKRPPVAKKRGALEADNTSQDNPPPPPPPKRQQTSMASTHLAQPMVFLSIGRQTLPLTADGGPNNSSKHHSDSQMAYEQWDDGMGNFAAQNFYYSVVALVVVAGIALLIGIDDVGQCIAQLLAFDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIK4</accession>
    <name>A0A367LIK4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ras-GEF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_6170</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LIK4"/>
    <dbReference type="OrthoDB" id="10254377at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF363">
        <property type="entry name" value="PROTEIN SON OF SEVENLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="346"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="1463"/>
            <end position="1711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="119"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="635"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="749"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="885"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="957"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1039"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1185"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1305"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1409"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="635"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="654"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="906"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="925"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="1001"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1057"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1092"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1185"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1219"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1305"/>
            <end position="1320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI14258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1711" mass="185928" checksum="DF1EC6838AB1C1BA" modified="2018-11-07" version="1">MDAVADKPKLAQASPRRRVGNKTSLASESSTVRRAFALPRPSVPSKPATALRSVPPPPLRPLLPVTERRSSEEKSGAVAPDGSSVGREGRQFAVANVGNNGRIYLRPTVRPANQRYPQPVFTFPITPPSTGGLDSIDRETSTSPKHEHDAEPPLGQSTPTPSSSPFAPELHHHHDLIGSRSPPRPTRQRRAMSDSTVDDADRDAYRVIIARPGLDKRPRTMEDFNSAATPLLHVDIPSWRIGTPRFTLRGTPIIRGSSYAPSEELWSGGPAVVDGVAPRPLLRLRNLGPPAPAATTPVGHGASRSPVLSPSAYTPPHFSSVIEPAMFSALTFKPACDDPSVVRYSPSGAVQAATPSRLVAEITSPSFLDYELISDFFLTFRAFLDSGDLLRMLMARLRWALARDDEVGMIVRVRTFVAVRHWILNYFVDDFVLHHGLRVMFCDLLNQVVDGLPPDESYRKVRLKILAELKKCWRRVCAEYWDGPQFGDSLSPEAPIAPGGLVGSRNPNLEPGFWEREGIQPPQPGALAPVPILSTIQSASLYVDARGTAPISDFAVLENRPGTPDNAVLYGPGLTVGPNSPLSLASLDIFSCSFPAKAPKATYPSAAHRTKAHPVPSTAPVTSTVQVATIPRALTGKRVRPTAAHRRNNSTSDSLRERGSEKSSTHDADFVAEMPPSAGGNLVRGNLLPPGQPFVEYELNRGSFRQTTLFRSESRDLVNDKAAASGAMTSRGMRKLLGSVRRALRSRAQGASPWQNHLQGASPVGHPDSTTNRMPGTAVVPPELPRPAGGRPPVRIDLLGAEVAEDFKKAIREEEAAAEAERLGMAVPPNSAPPFGGPTDYSAAHMEFSSFDSLPRPRPVSDMGITGGSKSIVIVDDTIPCEMTPAQRPVVDNSTADSFMPSRAGPTPPDTPPASSPRGDEPWRSSLSVGQQGTDGPAAVNDVGQLRVLDDQSLLSLPRCRRMRNPPASGGTFRKRKENRSIADQSQSLDSIIHDPASTFGGDGGGDGDGDGGYSSPVPPPSSWCFGSDVEVTESLMADDSLDAPEPAPLRVLRRRPGGDLRAAKNVGDLEERTSSPRRSRSFGSRAAYTESVRSSLLVSTRPNSAGQPESVVSHARQGRHEVLSLGQLAEKPTTAHLSLFNAHSSKPVMRASFEKEAQMLAQIPDEDDGGIESALLKLEGKYEKRPTTLPAEPRDADVEVDESSTDGDGTSTMRRRERKENRHVHVVDEAVAIGPDDDYERRAPPRQNTRQDAGRKLATDVKSFLSEGSHESYYSIPLLERGLSDGRRSKTATWEWTERSLLRNSGEEDVRVGRSKEGDEGQSEPAELTNSVEAPAVEDQSFLYDDTNGTDLSSELSAGATTSELFPAPIDDSRRAVTVHALQTPPLSGKPDDEAGAQVAVVVGQNHLPTPELSPAPRPCQASSMAAAARQPTPAPAEGSRSGLGGPLRNYSVHLPFILAFDSDILAQQLTLIEKDALSDIDWKELIDMKWKKAVRTDPRSWVDFLRRSDAQGVEVVIARFNIMVKWAISEIVLTQRAEERARCIVKLIHVASHCRRYRNFATLVQLTIALSSSEVTRLKRTWELVPGHEVETFHGLEKLVTPTRNFYAIRAEMEAGSDAGCIPFVGVYTHDLMYNDERPSPPCCSPHSPLVNFERYRVGASVVKTLLRLLEASTRYDFRPVEGVTERCLWIGALSDEEIRARSRSLERS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIP4</accession>
    <name>A0A367LIP4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar protein sorting-associated protein 35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_5919</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a role in vesicular protein sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the VPS35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIP4"/>
    <dbReference type="STRING" id="1330021.A0A367LIP4"/>
    <dbReference type="OrthoDB" id="10258141at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030906">
        <property type="term" value="C:retromer, cargo-selective complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.660:FF:000002">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.660">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 35, helical subcomplex Vps35-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005378">
        <property type="entry name" value="Vps35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042491">
        <property type="entry name" value="Vps35_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11099:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11099">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03635">
        <property type="entry name" value="Vps35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009375">
        <property type="entry name" value="Retromer_Vps35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="337"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI14313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="887" mass="99376" checksum="8241979E67B40605" modified="2018-11-07" version="1">MTTPAPPEDQARLLEDALAAVRQQTSLMRKCLDTPGKLMDALKCCSTLVSELRTSSLGPKQYYELYMAVFDALRYLSVHLRENHPVNHLADLYELVQYAGNIIPRMYLMITVGTAYMSIADAPVKELMKDMMDMSRGVQHPIRGLFLRYYLSGQARDFLPTTDSDGPDGNLADSINFILTNFVEMNKLWVRLQHQGHSREREHRIRERKELQLLVGSNIVRLSQLVDLETYKSTILAPLLEQVVQCRDVLAQEYLLEVITQVFPDEFHLHTLDQFLAAVSRLNPHVDVKAIVIGLMDRLSEYADRERPGKDKVAVQQAKVEAEALANLLQGITLPKDAPQIPDPALHDGDATALSPANGQSREGGSEQHQQQQPERVREDASSETVNGREVTAAAADGNSVQLYDIFFTQVKNLVEAQHLPIQDTIALLVSLCNLALNNYPDRLDYVDQILAYATTKTKENMNNADLHSSAAQQSLLALLQAPLTRYVSMFTALSLPTYVPLFQCQSYPTRRAVAGGVARTLLRDQIKITRTQQLASILDIMSVLIKEGSPATYPGAPQRRAAVAAAAAETDETQEEQGWLARMIHLLQAEDNDTQLELVQMARKALAEGNDRVRITTPPLMTACLKLARRFKAREHYDDNWETQCNVLFKLVHSALSDLYTRVNGSGAADLALRLFCSAGQTADMTGFEEAAYEFYAQAFTVYEEAVSDSKSQFQAVCVIASSLHQTRNFGKENYDTLITKCAQHGSKLLRKPDQCRAVYLASHLWWATAGGSGDSEPEATEPLYRDGKRVLECLQRALRVADSCMETATSIELFVEILDRYVYYFDQQNESVTTKYLNGLIELIHSNLAGNQQESSSIETSKKHFHQTLENIRSRQYEGVVLYPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIV3</accession>
    <name>A0A367LIV3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_6027</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIV3"/>
    <dbReference type="STRING" id="1330021.A0A367LIV3"/>
    <dbReference type="OrthoDB" id="4509994at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="116" mass="13219" checksum="1DD9031E7C41C898" modified="2018-11-07" version="1" fragment="single">LKNKIRTDKATFRDEEDRIGFLFCSLKGKACKTLETRYDSIKRLFSGLAEIIYLLTKTKDDSLSYEDFCGYIKDSAIKRLDAELVLPNDLPALAKYSLSILLPKTPLLNRQIDLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJ49</accession>
    <name>A0A367LJ49_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_6143</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LJ49"/>
    <dbReference type="OrthoDB" id="2320933at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18025">
        <property type="entry name" value="DEXHc_DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001039">
        <property type="entry name" value="ATP-dependent RNA helicase DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055124">
        <property type="entry name" value="PIN-like_DDX60"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052431">
        <property type="entry name" value="SKI2_subfamily_helicases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059032">
        <property type="entry name" value="WHD_DDX60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533">
        <property type="entry name" value="DEAD/H RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533:SF4">
        <property type="entry name" value="DEAD_H RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23002">
        <property type="entry name" value="PIN-like_DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26076">
        <property type="entry name" value="WHD_DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="791"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="1238"/>
            <end position="1415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="540"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1210"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1745"/>
            <end position="1778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1795"/>
            <end position="1828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="96"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="576"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1753"/>
            <end position="1778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1795"/>
            <end position="1804"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI14445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1856" mass="207858" checksum="B4D2E825D21B143A" modified="2018-11-07" version="1">MAEAEVDLISWYESISPLRVDVVGDFAGKELFAIHGDSLLLHCLTQSKVDFTNGFQLLHAIHAVEKFLTNLRQRGLNFHIIWFRDHEELCMPVSVDVEDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDSSVDLLTMNCPLLTRAILIRHLQEYCRDSLEFQFQFQNADCDEFRQYLACHNLRFFLCLDGNAFYGRWSTPAKHFLDFFHQVMFAGYSVAIINDVEFASLKVLASVFSSGYATETAQDVQLDIEECEPYTRESFQPLSELERRAGLEPGPWSPWNDGKPLSARDLISLTALCNVLLKRSDDDVKACVFAYVLHICMLRRMPLAQRSIPTTSLDSEEQEKIDSFLALFTDICISVVENLSPQETWDAYDLLDGRLFRRVYRNLPRLPPDMATEATKLVERIKQLIKVDISSCLPTASDGENIEPPGPAAPENGPDSCVLPFSHPVLEEFLEPVRLVADESAEPAQTSKVFQELTHWHNAKKPIDVKYTRQPLTVKAQRRNQRLMADTIAYSASLTNASGKTINPETIVTSISAANNTPVEGDGKARSGKKMPPKPMPSSKGKNSKQVKSGRDKALEEAQRVRKEKLGDKAGAVMSYWDERCREFQNEHNLIKRLAKALKYFNGLSSQELDSVGAEASLYICEVLAAMITQGKKTGNRAAGKTVPRRARSAIANSQPAEPGLLAMIWSKLLDTTRMQLSPASFFRLSKFSEALQMQLPTDLAPQTSLTARKLPFPAATGAPLKLPTSPVEFQLTHCGPYLDRSFDSAPDPRVPQFLPDAWQRSVLDAIDADKSLLVIAPTSAGKTFISFYAMKKVLRSSDDGVLVYVAPTKALVNQIAAEVQARFSKTYGHDGRSVWAIHTRDHRINNPTGCQVLVTVPHMLQIMLLAPSNAGKANSWSRRVKRIIFDEVHCIGQADDGVVWEQLLLLAPCPIIALSATVGNPQEFRDWIAATEKTKGRDLEMIVHTSRYSDLRKFMFNPPLGEWTFRGLTPASEPQIPGLDEGQEETSSFSFIHPVVGLANRNRGPIDDITLESRDCLTLWRCMAKHQTKDYPLDDSLRPEKVFGAIVTKPDVVAWSKSLKDVLSAWMRDPFSPFPAVRRDLGSSLFSPHSPSIPPADAVDSKSFGVKFDVKTSNVMSTALPLLDELHRRGALPAILFNYDRDYCEHVLIKIAEQLTEAESAWKDSNPEWKKKVAEYEKWKARTSKGKKREAQPIPIRSRDRDEAGPSKMELMQEASAAEPDKWENFDPEAPLEMFSFADRTKLLDSELAYWLERLEWTEVDPRIIGALGRGVAVHHAGMNRRYRQTVEILFRKGFITVVVATGTLALGVNMPCKTVVFLGDSVFLTALNYLQAAGRAGRRGFDYLGNVIFAGMPPERAFEVMSSRLPDLRGHFPLSTTLVLRLLGLMHHTGNSDFAAKAVTSLFKQSRICLGGPEARDAMLHHLRFSIEYLRRQRLLSRQCTPINFAGLVGHLYFTENAVFALHGLLQEGYFHRLCANFQKNTHDVLDEIVLVLTHLFVRLPVHNVKRAKKIARRSPSMVVLPPLPEEAKKIMLDHNQETLEIYRAYVSTFVEQHLDMTQDNRLPFTGCQVAPEKAEKDWQPLVKTLPPTKLRSWFDALSGFTDDFESLSELCSTVRSGVFLEESAVPQVRIYPEDTAGVPWNAFIYDFFKHGDLTALVRDNGIQRGEVWFLLKDFSLVLATIVASLETLLSSTSPLDDDDNAMLDLQDAGDVIQEDRDERQAGEPEPSAAAASATTTTTNAASEAAAPAASRKASKKKVVLDSWDDELGDDDEEPQPVAATKTPSESSRVPSELGWRTDEEEGLTSVLAAFKVLQTDFDEKFKKIWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJE2</accession>
    <name>A0A367LJE2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7078</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJE2"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="213" mass="23926" checksum="09E473CFA34C3B93" modified="2018-11-07" version="1">MDSLLIREKLQGALGSETYNKSEEALALIRLQLEDGPLTQIMHIKTALEAWNRLKELYNPHSAYSGVGSIGLTRTSLPPNHRSSKYVRVLQVGTLKYLEKIISISFSHLLNTNTSPASNSSLIASFRLSRHLEQIRPIDSLQRSSQRSARYTYSGHSTRLISAQGSRHIDRRAVPIAVIALDQSQIVRLIHNVKVFLQITYLPSVTYSHVIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJJ3</accession>
    <name>A0A367LJJ3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_6830</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Endoplasmic reticulum membrane</location>
            <topology evidence="2 11">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the OST1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJJ3"/>
    <dbReference type="STRING" id="1330021.A0A367LJJ3"/>
    <dbReference type="OrthoDB" id="310030at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000005">
        <property type="entry name" value="Sphingolipid long chain base-responsive pil1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1980">
        <property type="entry name" value="Nitrogenase molybdenum iron protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028245">
        <property type="entry name" value="PIL1/LSP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007676">
        <property type="entry name" value="Ribophorin_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21049:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21049">
        <property type="entry name" value="RIBOPHORIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13805">
        <property type="entry name" value="Pil1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04597">
        <property type="entry name" value="Ribophorin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016483820" description="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1" evidence="11">
        <location>
            <begin position="20"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="560"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="894"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="798"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="562"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="589"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="619"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="662"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI14605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="929" mass="103016" checksum="B051ED17CC943F8C" modified="2018-11-07" version="1">MKPPSFASALLGLAVTALGSSVPAPSSSSSPGATEAFRPPPVFRNVNLVHVISLEKNYVKEQINVLIENVSDKQQDEYYVPFTADQMARVGGLEVKDRKDASAGPFFAEPADHYSRSDTQYYRIRLPASLKPGGQQTLGISFFFLKAYTPLPASIKQDEQQFLSYSFSAYAPSAYPTMKQKTEVKASSASIPDYTKISGKDAKVEHPQKQGSKLTYGPFEGEIPAGAVSPAQVRFEFTKPVTHVSILEREIHVSHWGGNVAFEEKYTLQNHGANLSVPFNRVKWAQSQYYNPPSTALKEMRFPLQAGSADAYFTDTIGNVSTSKFRSGKREALLELKPRYPIFGGWKYPFTIGWNVNSAKVLRRTASGRYVLKVPFIEGPKQVEGVEYGRVNVRVLLPEGASDVQVTTGIPESSITELSHGVHKTYLDTVGRTMVTMEARNLVDEFRDRAIIISYDASVGAALRKPVIVFFSVLALFAAAWAVGKVEVGFSKAKGGGEDDRRSTIEDVARKSLSRVTVSVCRSVLAGSLVDTVKKATGVMCFGGEPKTKYYYHEEIIPSRPSSRHHHHHHDGHHHGHHHHHHHHHGQSPRASYTSVTRRSSPGAVIYERTTDHKVRNKPAQQTRQMSRSSVDLSHLFIGHSRHDENATTDSPPPHRNRHSIRASNKGNKSGFSFSSLRGNSHQEPSRRIFRLIKAENSLVSTHLTAGRERIAIAQQLSEWGEGTGDEAVSDLTDKVGVILSEIGEQEDAYAHAIDESPSRLKAIRNTEKSVQPSRENRARMAEELSRLKAREPDSSKVVVMEQELVRAEAENMVAEAQLTNVTRQRIKETYDAEFCAIIERAEKQIILAKHGRRILSLLDDTPVVPGDNHHPYSSGPQARQVLDDCAEDMREWQPDHDTYLDPVSNKPPGDEAEEAAAAAMESAEEGHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJX3</accession>
    <name>A0A367LJX3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Actin-like ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJX3"/>
    <dbReference type="STRING" id="1330021.A0A367LJX3"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="621" mass="69912" checksum="7436A1BFBD2DC2D6" modified="2018-11-07" version="1">MNTRKRKAPDAPRSIYVGLDFGTTFFSLLSPAHLSLPPYRYSGIAWAPAEDDINVISSWKTSNLAHGDKKKVLTTILYGDNHRQLSWGYEILPKDVPLKWFKLLLIDDEDLPPHIRDSSQLKEAKLQMQTANRHVVQVIGDYIKQLWKVSYQDIERSMGRKQLASVHFHLMVTVPAIWPLYARNRMQQALVYAGVLSERSVVGFVSEPEAAAVAVVRDFGRRACIKKNDHFVVCDAGGGTVDIITYKCHREAPMQLRESVKGAGNFCGAVCLDDGFRDLLKSKLSPIVWPKIGRAGINEVMVNQWENGIKINHREDVDVEVPVAYGDTLIKVKISKEEIANIYKPIVAETVDLVLKQIAETKRKFNKNPTVSLTRACFEPPADFLSPFQYVILVGGFGKSRVLYKALTDAVFDHGLRIEVLQSQGDNPIFRYDRWTAVCRGALLRGLSQTSSNPWATIDARIARASYGTTVNILPWTFGEHDARDREWCPLEGDFLAMNQVQWFIEMGETLAVDSPVVKAFWQDVEAPEGEVSTEIVISTASPPPYRFNGNVSRLCLIRWAKVPNFASLPRFTNPAGKVVRQIPYEIRMVPNGMSLDFEIFHDNVMVASKNISVECDRESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LK28</accession>
    <name>A0A367LK28_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Heat-labile enterotoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_7010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LK28"/>
    <dbReference type="STRING" id="1330021.A0A367LK28"/>
    <dbReference type="OrthoDB" id="4924915at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.210.10">
        <property type="entry name" value="Heat-Labile Enterotoxin, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016752221" description="Heat-labile enterotoxin" evidence="2">
        <location>
            <begin position="24"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI14612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="711" mass="79923" checksum="8FD4726ED7B9890C" modified="2018-11-07" version="1">MKMLRVSPAILLLLLCLLASVRTASSDGGQGPPEVEAADIIYVFIWDPRPPGQIRADGGWRPPNQDYEDNMRAFFVYHHELGQWDDEGRPREARWATAYVTAYVNMADAQGGRQEGWLYRIRVSRNMVMCVDNDPSRVYALGGIQWAQVRSYRLATSTIFILIRRDHNFARYVQDSITVLPSTCSLFIRDPGMWDCWYASDFAHLLLSHPLLGPRLGYLGFFPLCFERFNNETTARPGSNVPECQPGPSGSRNRGRPGRQNLTGTSAMLNEHSHSSGSRENCEAAAPRAACCDPEQERVDEEWIDKYLDSVVLRSSLDHNEAGQAEQLDEADQAEQLDAEEPAEDEERPRKKQKPNNDTVLPYETTTPNPLEQPGTSGLSINDVDWRALAAFAALCEMASGGSHQKRSAYEFHNKKACDDAANKIRKLDSCERITGLEVGVTLSNDYWSGTSSEISLAFDGSQGPVRIPIADGPSRGFNTWKSFGLNDHGISELKDVKNIRLETREKSSFPWFSTAWRLQDVELRGRCVETNDLVVMEKYKSLNQWFETPNKDITTWQSVGNLAVTTPDWKVKPPCNYLSSLTVNFTIGDRNWAGTGHTITFSVNSMSKPIIIAKAPSRGTFVSKKLDLADVVQVRDLNKMSLLDQTSRDWSLTAGWFLKGVTLSGECVASRKRISMNKFKAVNEWFEHQNPIEQLEPVWGGEFSPEDWSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LK65</accession>
    <name>A0A367LK65_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_6399</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LK65"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="119" mass="13739" checksum="B32CF3340F2F840C" modified="2018-11-07" version="1">MTILAYRHVLAYSHILYRETDGLFQSHIRTLQPTVRILTYFIRPVRGRAALEIGGERDGCLMGRVRTVQVFYISIRVRAPYLPRNKQEVCAHYGHCQCQSVNNLTYIHVLPHNTVDSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LK69</accession>
    <name>A0A367LK69_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6703</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LK69"/>
    <dbReference type="STRING" id="1330021.A0A367LK69"/>
    <dbReference type="OrthoDB" id="5418235at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542">
        <property type="entry name" value="HELO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542:SF2">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="550"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="716"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="831"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="849"/>
            <end position="862"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1164" mass="127588" checksum="0C2743DDCAF7E18F" modified="2018-11-07" version="1">MNSTMSPMAGFQLSFHRRLTRLYSDTKKSTDFVREPLRHDGNDPDIKTLQRKMRIQKDRLVSWGLEWSDSAQSTDIDHALSRAGLSDVVASIMSTIKDILAEAEALWLASECLVGQPRSSIDKKPPLVRWDKARFEDLVRDLTVSIETLYDLSRSRSRTAMPRCMSAIGYKAAAAAAAAADDPRLFGSSRVQTPRHIDPCSLTRLMPLAPIDDEPPRHVVLLVEAPCSDLARGSVNDPQAPLLLEYAAFDPIYANTGIMPDMARFERLSAGLQQDPQCAVGSWIGLPRLMGYFEDMDNARLGLLYRFPPHFHVLSSDSISESTPYNLFTLGDLLLRPHSEPPLEAKLRLAFNLANTIFDMHGRGITHGKLDDRNILFPPDTSGEHRAACESVDVRCPLVSAFDLFPDDSAANSPSLWRHSGSIRSSRVSPLDKLTEERVLDLYSLAMALLSIGLWVKLDTLASDLESPDCLLRRLAVKCGGLFVKATQACWHVVDADASGSNSSQALFSAVEVRVSGYLETCCALDSVSGLEWRLSLELKRDGLEKRKASEKANEARACAPNTSAASDRRRALTAPEPVTTRQSGSVDAAECRSHDNLGGQETADKSETRIRLYPHVPLAPDVVERWNTSLMPQINHALRHFYRKHPESVEVSLGSVGPSPSKAQPTALIVCTSVSKVRAILKKRFVELFDGSIGIGVRVCRGHVIRSRRQAKLVTAPVAPTHRSGSDPGCGSMSDDGEDAAVNPDYQERPGNGASIGAWIGYRHLPPVSFGGLVMVDGQPYGMTVHHMVDEPDRELRPHDILRSSTAADPRRYSNFADEVGATDDDFAQGLSEAEPEPCSDSDVTSDYGEDDSEADDEFEPGDIPGIEPGCGDGYLVTQPALDDVGDDFYPCAETKNEDHNDSFHLGRVFASSGIRRKQVNGLVHEVDWALFRFSDGRLPDDNRIPRAMDRRWSSDHGEAAHLRPTSVAPSSSLPGMEVQCVARTSGIQTGQILPALTTVKIYGRTSPSHAYEIASSREFAEEGAHRSLGIPGDSGAWVVDRRSGQLCGHIVAWSQRKRVAYICPMDVLLLDVAQTVDATEVKLPGGEPLQVVSDTGMKNRCEEHVHAAQMMMHPSTSMPRLHMNQQDASKLVVGLGQTSEFEGLANKMDDLSISKCRRIGVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKY1</accession>
    <name>A0A367LKY1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKY1"/>
    <dbReference type="OrthoDB" id="5397330at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="221" mass="24407" checksum="B765A3DE662D236C" modified="2018-11-07" version="1">MPIRNPFNRKSSVAAVAPDDGLRPSYPGFERVDTVGSKALSIRSARSQDTGEYKMSVVNDSGVYLPPSPPDERAPWPRRYLSSSRNSSDTRSSSDEFQQFSISRESFDSYRRSFDISARSPIASPPRQSLESPKLHCPPRSAPNRHFPPADDSFEDIGLEDDHSKQPRRRGFFSKFGEPVDAGAASPAVSRFLMPGRKRGHGGQDAELGIMHQPSAEEGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLH1</accession>
    <name>A0A367LLH1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLH1"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="66" mass="7217" checksum="8AEB35F30E0283B1" modified="2018-11-07" version="1">MGLPPNYRSSKYVRVLQVGTLKYLEKIISISFSHLLNTNTSPASNSSSIASFRLSRNSSSSSLLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLI0</accession>
    <name>A0A367LLI0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLI0"/>
    <dbReference type="STRING" id="1330021.A0A367LLI0"/>
    <dbReference type="OrthoDB" id="3519400at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="130" mass="14172" checksum="5B1570AC33EEBC38" modified="2018-11-07" version="1">MATSPSSSPSASPASPPTTSYNHHQTTMMTPPSPPSSSPSSSASSSSSTMSDLDIYHLDAESRHHHAWLQPIVIDDDDLTFGGKPLCAWYEEERSRLSAVSSPSSSPSSSGDEEHRGRERTRRHYSPHHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLJ2</accession>
    <name>A0A367LLJ2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin-like modifier HUB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_6484</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLJ2"/>
    <dbReference type="STRING" id="1330021.A0A367LLJ2"/>
    <dbReference type="OrthoDB" id="3881at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039732">
        <property type="entry name" value="Hub1/Ubl5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13042">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="4">
        <location>
            <begin position="120"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00014108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI15288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="195" mass="22204" checksum="B4EC450D7D05CC76" modified="2018-11-07" version="1">MTDNSRSRSRSPARRAPRGSKGFRWKDSSRSKAADEDGAESSRRRQDYRNRSPDRQRRHDREGDRRREPERGEEKDKRRSDRPRSPRRREAGSSKSKQATTTTTTTTTTTTTSVAQQEMIIVHVNDRLGTKSAIPCLPSDTIGQLKLMIAARIGRESGQIMLRRQGERPFKDMLSLEDYGISNGVQLDLEVDTGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLT8</accession>
    <name>A0A367LLT8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLT8"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI15222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="61" mass="6938" checksum="73147089DDF77C61" modified="2018-11-07" version="1" fragment="single">YITCGYFPARYKESNVIVLRKAGKSLKGYPTLARSYVRTYESAFRLNSSSKRIPRRAASST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LM54</accession>
    <name>A0A367LM54_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_3452</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LM54"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI15489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="294" mass="32014" checksum="492AB28906B76AB4" modified="2018-11-07" version="1" fragment="single">QPIFERKKSGGGGAGGKRPVRRGDERGGVWKKRQKGKGTACCYEKEEKKKRVSLTPGLDVFFSKVTSLGCVFVFNNVVVVAIGKRKRKRKKKKIYESLTHSLSPLLSSPLLSLLFHHLLTPHSSLLTPHPSRFLLPPSPSFIPHPTAIPSSPIASSSFFLFPSANINLETSHKSSDALRAPPLRLAVQPTSFVPLPTLVNRPLRQATDFLPTLVAHSPSFVLRPISTVTYSSFDPFTSTKARSDLGRQKTLVPVPLSVLVSMTTPTAGTRLSITRALGSGDIGGSKTTHESTRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMC6</accession>
    <name>A0A367LMC6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_3577</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMC6"/>
    <dbReference type="STRING" id="1330021.A0A367LMC6"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051965">
        <property type="entry name" value="ChromReg_NeuronalGeneExpr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46040">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46040:SF3">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="5">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="111"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="3">
        <location>
            <begin position="111"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="85"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="194"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="226"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="346"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI15537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="477" mass="52218" checksum="7267632167E42CB9" modified="2018-11-07" version="1">MTRQLEAVFAELGLSQYLDAFIDQGFDAWDTILDIQESDLDALGVKLGHRRKLQRRIANSRGIAPSISLACAKPSTEDARHDLVRTETGQESNGIAKRKYRRHPKPDENAPERPPSAYVLFSNKMREDLKSHNLSFTEIAKLVGENWQGLPPAEKESYESQANAAKEKYHASLASYKKTPEYRKYLQYLHDFKEKQARQSRGHDASKRLKVEPPRLRHSSTSCGATPGGATPGGSSGSERLNGSEPSPSRNDSQYTPTSQHSPAHVTDESRPSRFDASPQYKHSRRQPSWSRNHGKHLPSLSDMMDDGQNGAYSSGRGGSGQTKMVSDGPPVLPRAQVPRLLHEPSSNSTTESRSSRGSFTRSHGDGSLPIYKLLTDRTIPATHNVEQMSTSPIKAAASPGVGPERPSGPMPSPRGYGFLSDSTAFQKMNIDSSSDGDVLMSPVPASPASSNNLKRGLDGMSALLHAGEIVGRREHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMD9</accession>
    <name>A0A367LMD9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMD9"/>
    <dbReference type="OrthoDB" id="3519533at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="177" mass="19255" checksum="63CBA3C19C30F3A6" modified="2018-11-07" version="1">MESLQLSQVLADLSNLGAAEPETAAAIVNASMPMRPQIVKADSSTAPSPAASQQSRPQRPSSIQRAWTTESNTPPKFDKLGRRLLISTPGSRPGSAANSIPGTPRRGDSDADDDWERANTLMALYDIRAKIKQQDNSSLMKAREKINALAAKQAAERSMKTSEELRRNRYSYPKSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMR0</accession>
    <name>A0A367LMR0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_2226</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMR0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI15726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="102" mass="11655" checksum="DC7358ADE2A1BDAA" modified="2018-11-07" version="1" fragment="single">SQSHLFLDITLSRGKGMDDDDGLKLGRETIPCKRNVPFHLSALHFTSYIHSIAPPSLLRLLPPTLQCVKPAHRCRVKLVFELSGQQQRFSLRRIFLASIVYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMV4</accession>
    <name>A0A367LMV4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 13">Ribulose-phosphate 3-epimerase</fullName>
            <ecNumber evidence="8 13">5.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L249_3559</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>D-ribulose 5-phosphate = D-xylulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:13677"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="EC" id="5.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="15">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">Carbohydrate degradation; pentose phosphate pathway; D-xylulose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 13">Belongs to the ribulose-phosphate 3-epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.1" evidence="8 13"/>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMV4"/>
    <dbReference type="STRING" id="1330021.A0A367LMV4"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00411"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004750">
        <property type="term" value="F:D-ribulose-phosphate 3-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00429">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000130">
        <property type="entry name" value="Ribulose-phosphate 3-epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02227">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026019">
        <property type="entry name" value="Ribul_P_3_epim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000056">
        <property type="entry name" value="Ribul_P_3_epim-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004076">
        <property type="entry name" value="PRK05581.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11749">
        <property type="entry name" value="RIBULOSE-5-PHOSPHATE-3-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00834">
        <property type="entry name" value="Ribul_P_3_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001461">
        <property type="entry name" value="RPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01085">
        <property type="entry name" value="RIBUL_P_3_EPIMER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01086">
        <property type="entry name" value="RIBUL_P_3_EPIMER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="12 15" id="KW-0170">Cobalt</keyword>
    <keyword evidence="11 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="15" id="KW-0464">Manganese</keyword>
    <keyword evidence="10 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="14">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="14">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="35"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="173"/>
            <end position="176"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="224"/>
            <end position="225"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00009541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00013920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR001461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001461-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCI15572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="251" mass="27222" checksum="0CCAE1FD3B024F40" modified="2018-11-07" version="1">MAPPTIIAPSILSADFAELGAECRRTMEQGADWLHVDIMDGHFVPNLTFGAPVVAKIRKHVDPPAESNGRGTFDCHMMIAEPKKWVKEFKKAGCDLYCFHYEAAFSSAAESPEESSDRKTNPRELIRYIHDQGMLAGIAVRPDTSVDVLWDILETSDAAEKPDMVLVMTVMPGFGGQKFMASELPKVEALRSKYPDMNIEVDGGLGPATIDSAARAGANVIVAGSAVFGAKDPADAIKTLRNCVDRENGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNL9</accession>
    <name>A0A367LNL9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_2314</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNL9"/>
    <dbReference type="OrthoDB" id="10621293at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI16044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="198" mass="22479" checksum="E9A951FB4908701F" modified="2018-11-07" version="1">MEFLSVITRTLTFHTKGARVSLARPLPIKGVSPEPTDHVMPFTRTMMARMNRHRLLITMEAKFVMGVVDGWGYPTLIAKHLNRQPSDRAVGFSIPHANHDRSALRPPPSVPHTFFFHLGIIRNAVSPRLPTPFDFQESSVGSFLFFLFFLTPFHPSPPSQFAPLSPPSDGAHRENKTRTQRARIRLYVGWRLIVESLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNP7</accession>
    <name>A0A367LNP7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNP7"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="133" mass="15777" checksum="81C7CE2B8759FC79" modified="2018-11-07" version="1">MMEWRWDGVQRGDRLASWHRIHAYYIRFFSNLTTDTGEGKARGRGKQSYHTTDYGVLVYPRTFSHMGRKGTANQRRRPLWQFVVLPPPLVCFVSGRKAKAEMTRGGRKKERREKKKQKKKKKRKKKKKTPGQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LP24</accession>
    <name>A0A367LP24_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">UDP-galactose transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_3081</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LP24"/>
    <dbReference type="STRING" id="1330021.A0A367LP24"/>
    <dbReference type="OrthoDB" id="408493at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005799">
        <property type="entry name" value="UDP-gal_transpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="425"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI16131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="462" mass="50852" checksum="1B48E4734A7B158B" modified="2018-11-07" version="1">MTILEAAGPRRSKATTLAEDKVGRNLSFLTLTFQNSALILIMHYSRMMPPTGDHRYFTSTAVLLNEVIKLAVSLTLAIYETSQTLAPSTPATTLFEQIYDAVFSGDGWKLALPAAFYTLQNLLQYLAVGNLDPVHFQVLYQVKILTTAVFSVFLLRRHLGLKRWISLFILTLGVSIVSLPTSESSVDARLLHGIPDHYFPRSNHELGQAAVPDFSPPDTHLTKRSATYQGIANDLPPPDPLMNYSAGATAAVVAAVVSGLAGVYFEKILKESPTQASVWIRNIQLSFYSIIAATVGGVFWQDGNGIRQHGFFEGYNWIVWSAILLQAAGGLVASLVIRDADNIVKNFATSISIVVSFIVSVWVFKFTVTMSFLFGTSLVLLATYLYSLPERSRHRPPAVRIVSFEKPAIERVVTPGTTPRLTDVARLNSDPFDSKGMAMTSSRPNSPMLPRQASRTHVLRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPC3</accession>
    <name>A0A367LPC3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_2390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPC3"/>
    <dbReference type="OrthoDB" id="4021778at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026749">
        <property type="entry name" value="Tmem135"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459:SF15">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12459">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 135-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016636171" description="Integral membrane protein" evidence="3">
        <location>
            <begin position="27"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI16295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="441" mass="48818" checksum="6D1B1D4B970CC814" modified="2018-11-07" version="1" fragment="single">DRRKRKRKRSSLLASILLILRTSLEPGRFPAFCALLVGGSSLLHKPLATVVTRVARPPLSDAACLSLARWLASFVASWLSLGLLQKRRPSPLPREEPPPPSSALVPAPAQVPNEDDETTTTAGKTLDLTLFAVTQALDVVIGELWSRRKARRVAARQWSNLDGFISRMTDPMTFVVSCAFIMRAWFYAPDSLPRSYNKWITSAAHLDPRLLEALRRCKTGELRYGVDTGQAPLLGSMCADYGLPRHWGDPAVSVPFPCDVVHMGRGPSCEYHAWRRFSQSWLWSMYTYLPLAAALQLRRPTLGSPFKAVVSAARSSAFLATFITLFYYGVCLGRTRLGPHVLGRDPTSCDRIDGGICVANGCLLCGWSILIETTSRRKDMALFAAPRAMATLLPRRFPTSLQWRETLAFAASTAVVFTCVQENPRRVRGMLGGILSLAMRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPE0</accession>
    <name>A0A367LPE0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_1727</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPE0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI16314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="148" mass="14451" checksum="93443BB612BED233" modified="2018-11-07" version="1" fragment="single">GPLLYVRNKADERYQGLAAIKASPAAAINTSLAAAAAAINTSPSAAAAAINTSPAFPAAAIDICVSRYTSRGEASSAYAAASLAPASISTNAFLAASHAARPYRQALLTTIAAALVPLASFKAAAAASASKATAASGAAEEEETAEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPN8</accession>
    <name>A0A367LPN8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPN8"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="156" mass="16788" checksum="30B9277777AF284F" modified="2018-11-07" version="1">MDGMGSLQARNPVRAGGRPSANGVARPRHSRTLIVSIPGELEDRRLAPSSPLTQRAAASRKASSSFIIMLIHFFFDLSSCPPIPEHEVRRGGVVMGERLQGRLAVEGNGVCKMWDTSSLPRGGRILPPFCSSPYLTLTGGGEEEGEKTTTSDRELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQ85</accession>
    <name>A0A367LQ85_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-rRNA-processing protein IPI1</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Pre-rRNA-processing protein ipi1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L249_2903</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQ85"/>
    <dbReference type="STRING" id="1330021.A0A367LQ85"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024679">
        <property type="entry name" value="Ipi1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12333">
        <property type="entry name" value="Ipi1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="14">
        <location>
            <begin position="472"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="503"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="725"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="353"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="883"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="10">
        <location>
            <begin position="472"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="359"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCI16613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="951" mass="103671" checksum="EF5D6B840B5877FA" modified="2018-11-07" version="1">MGSSAKKKRDKKKDFQKPKYKVGKAKAKASTHTDLSFKTKAIAVGRQTLSTTAPGGDEQFKHYLSLASSSRSDKQRQEALSYLTSQLSDEPSCNAVGTRALLNKLLPLVSDSSTPVRSQLLKLLRTLPRDEVKSGVEQAIMYVRAGMTHLSSDTSMDALGVMEWLLDVAGSELIACPGGWDKTLSTFCAMMGWSVSQSTGGWTGSVGAGLKGRDGQMLVRQVTALTRFLEAGFRAETAEESKASEYWDSLYRLPRAAKAFAHLGLTDERRDAEGDMYPDREARQMIFQRKFLEPICKGIESAKKEGGPAGRAATLLDNVVRLGMADFEEQAGTDGDDLLDLCALGAPSTAHPSIHPSAYFSTPDSSSTGTMGNANDDSGAKASDTAIPGWVTNQAIDYTSAANPGEEATWDGNARIYEWNDEYGDIGPKFPELELELFGDPAARHERIGLDFQKIDQIEVQQEGPVKIDAIRSFKTAGLHPCIEENVKLSGYENPTPIQKYTIPSILQGYDVIGIAQTGSGKTAAYLIPIASKLMGKAKKLAAPRPNPAMYSEDMGVVAEPLVLIVVPTRELAVQIFNEARRLCYRSMLRPGVVYGGTPIREQMRQLGKGCDILVGTPGRLVDFITRPNVLTLRRLKYMIIDEADEMLESDWSEDIGKILCGGEQDEGNIVYGLFSATFPKAARDLAKEHLSASHVRFRVGRAGSTTENIQQHIVEVDRNDKRQTLVRLLEEMHGVRTIIFTNSRQSVDDLDDFLYNMGLPVTSIHRDRTQMEREAALRAFRSGKAPILVSTGVMARGIDVRNVMHVINYDLPSMDHGGIEEYTHRIGRTGRIGHRGVATSLFCDRDEPMASVLTRTLLETKQEIPDFLQSYVPDGEAAEKPKFEADSDFDPNDLGTMESLNLGGGDDNGWGEKADQGAQDGWGGGGEAQANNSTSAGGGWGTATPAASGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQR5</accession>
    <name>A0A367LQR5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_3018</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQR5"/>
    <dbReference type="OrthoDB" id="273452at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482:SF65">
        <property type="entry name" value="ESTERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="336"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="DUF676" evidence="4">
        <location>
            <begin position="80"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI16751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="506" mass="56715" checksum="4B462203AEBBD3B6" modified="2018-11-07" version="1" fragment="single">SSIHPVLRRVSSPWQHQTTASSDIELFSSIWVRQLSSNRRQLEARPALSSPSLRIRSFPGSGGVAMSAPELDGDYMGGSHDADHLCVLVHGLWGDPSHMKNIAKALRSQYSRDRLCLLLAKRNSGSFTYDGIELGGERVCAEIEEELQSRAGKVKKLSLVGYSLGGLVSRYAVGLLYAKGLLDEVECMNFVTFASPHLGVRSPLKGWHNYIWNYVGARSLSMSGRQLFTIDKFRDTDRPLLSVLADPSSIFMRGLRKFKRRTLYANIVNDRSAVYYTTCIQKTDPYCGNMQKIEPKYVQGYESVVLDPEVPYTLRSGSSHNTSSPTSTALTWVKRLPLIIMVAVLVPAGTIAFLCNSVIQTAKSSDRIKRHEAGQANVNVQEYRVPLMLKEMRGEMEKAYGALNNSQSQDFLASDEDDVDADIGVEGRLVMSRERRQSSSTQPTLALTPHQFQMIDALDELQWRKIPVWIHNDRHSHAAIIVRFAKKSFDEGFLVLRHFAKGEFLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQU4</accession>
    <name>A0A367LQU4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_2947</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQU4"/>
    <dbReference type="STRING" id="1330021.A0A367LQU4"/>
    <dbReference type="OrthoDB" id="73901at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF120">
        <property type="entry name" value="HIGH-AFFINITY COPPER TRANSPORTER CTRA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="4" id="KW-0187">Copper transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI16823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="193" mass="21145" checksum="5166AE2B61C78446" modified="2018-11-07" version="1">MATLQPRHAGHGSTTEAEGDPSMSTMMMAMIFQTSMETPLFTTTWTPRNAAAYAGTCIFLILLAVIGRLLLAARSWQEARWHDADVRRRYVASPDRPDLARRLSANREAKQMTLSENGVEENVVVVARDGPVVRPWRFSVDPVRALLDTVIAAVGYLLMLAVMTMNVGYFLSVLAGVFIGSLAVGRFCSGADH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRK7</accession>
    <name>A0A367LRK7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_2120</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRK7"/>
    <dbReference type="STRING" id="1330021.A0A367LRK7"/>
    <dbReference type="OrthoDB" id="289314at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06867">
        <property type="entry name" value="PX_SNX41_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044106">
        <property type="entry name" value="PX_Snx41/Atg20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051079">
        <property type="entry name" value="Sorting_Nexin_Autophagy"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46979">
        <property type="entry name" value="SORTING NEXIN-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46979:SF2">
        <property type="entry name" value="SORTING NEXIN-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="10">
        <location>
            <begin position="92"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="432"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI17084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="619" mass="69262" checksum="D9BD7DEE33139FF2" modified="2018-11-07" version="1">MWNDEDNNPYGTTFDRRDSQTSSSANPTSPTSHDYRPFDALHTPTSDSDDDQTTTFRNSAVHEDPHETTAVQDLTPKRKPGGYNSRIEQILYENPDMPIIITDAGKSMESGGRYIVYTIRTGDLEVRRRYSEFASLRDALIRLHPTLIIPPIPEKHTMADYAAKPTSAKQDQQIIDLRKRMLAVFLNRCRRMEAVLNDNVWWRFLDPNASWNEVLHSHPVASIPKSVLKAPPLDTANPTPAHAYLPVPASSAKLRTTAGTNHDISSSAIQAGMHSVGRLPPANSNRAEQDLDNHFIAYEASTKELEQLLMGSMEKVNRRTLSHLSSLATDLCELGSRYNAFALSEQAPSLGTAIERVGQAADLSYIATEELSGSLGASFAEPMRENAQFTGVVKNVLRYRVLKRIQQDLTTDELYKKRALLDQLERSESEARRIEQYLSSSQQLSPPPKRSSSAKEPAAQHRREGGQEDTESIDSDFPPAHGDFPSPPPSASQGLPERSGSVSHRKIPSGNSITNKIFGPIRHAVQGVVDVDPERTRRDTIGKTRESIGQLEQAQIVSERDVKEASASVLQDMKRFQKDKEDDLKRYMLAYAKSHIEWAKKSKQQWEEARAEVDKIDET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRT5</accession>
    <name>A0A367LRT5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PhoD-like phosphatase metallophosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_2101</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRT5"/>
    <dbReference type="STRING" id="1330021.A0A367LRT5"/>
    <dbReference type="OrthoDB" id="2100241at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052900">
        <property type="entry name" value="Phospholipid_Metab_Enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43606:SF2">
        <property type="entry name" value="ALKALINE PHOSPHATASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G03860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43606">
        <property type="entry name" value="PHOSPHATASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09423">
        <property type="entry name" value="PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase metallophosphatase" evidence="2">
        <location>
            <begin position="295"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI17129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="620" mass="69647" checksum="66480B9C4C0DD4FB" modified="2018-11-07" version="1">MALQTGLATVVSVALRISSVIFFRFAHLASVTLALFAVYVPAFISSYCTDYRAVQDRTDVVAQKTTVTAKTPLFTKNGVAIERDPVTTVDLDVKERVVFAEKSPRPWKVLLFGTPSAARPKLSALALLVNLLLAGMATDALFRARLYYPSHDLSFVRLGYVSPTEARFLVREPDQAKLPVTLEVRIMDSQPPLDNPLWQKAGQADWTSNVTDYTAVIYAPLRHTEQRRYEWRTSNNHAGEFLVPPMPGAVPRYNGGKFTFLSTSCILPRFPYNPLDHPLAIPGVRYLANKLPDLGAQFMLFLGDFIYVDVPQRFGKSTEEYRMQYRQVYASPDWAPIGQNLSWIHVLDDHEISNDWSANTTGVYTDAVDQWHIYQAQVNPPTVNADGRGPGRPKATWFEFVQGPASFFMLDTRSYRSSNNVPFDESDKTMLGGEQLADFLAWLARPEPTGVKWKFVASSVPFTKNWPINVKDTWGGFLVERKKILEAMWAAGSRGITVVVLSGDRHEFAATKFPPPAESQWPEAAAAFEFSTSPLSQFASPIPTYKQEDDEDVMLKYIPAGSSKFGAFTIQNLAGKSVLDYQLFIDGEERWSMRLFEAPAPEKFTVGGSFWDRFKLSFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRX5</accession>
    <name>A0A367LRX5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Iron permease FTR1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_2369</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRX5"/>
    <dbReference type="STRING" id="1330021.A0A367LRX5"/>
    <dbReference type="OrthoDB" id="4364at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004923">
        <property type="entry name" value="FTR1/Fip1/EfeU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632">
        <property type="entry name" value="IRON TRANSPORTER FTH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632:SF2">
        <property type="entry name" value="PLASMA MEMBRANE IRON PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03239">
        <property type="entry name" value="FTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0410">Iron transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI17147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="355" mass="38909" checksum="AEAEC8822FAD22F5" modified="2018-11-07" version="1">MTNQGDTFFSLPVFLIVFRETLETVIIVSILLAFLKQTLNQNDLAYRALKRQVWIGVGSGFLLCLIIAAAIIAVFYTVRTNSWEPNENYYEGAFCLVASLIITVMGTALLRVGKMQDKWRLKLSRTLEDPVKTGSRRWWARLPEKYAVFFLPFITVMREGVEAVVFIAGVSFSSPATAVPLAVAVGLGLGILVGWLLYKGASSAKLQLFLVISTCLLYLVAAGLFSRGVWHLEAQEWNIAVGGDAAETGSGPGSYDIDKSVWHVNCCSPTGPQSGIWGLLNAIFGWQNSATYGSVISYNMYWIAVITAFVLMRFHETKGRWPLFSTKSVNNNKENAHSTGHPGGAVVAADSKHPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LSL2</accession>
    <name>A0A367LSL2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LSL2"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI17445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="66" mass="7798" checksum="DF6FB7BF3AF84F58" modified="2018-11-07" version="1">MVTTTTTTTMTRFDIANPRRLQTKAERRKGEKAGAMREETERKEEEDKTRQDKTKMWRQSYGSVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZ85</accession>
    <name>A0A367KZ85_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ketoreductase (KR) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000028">
        <property type="protein sequence ID" value="RCI07477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZ85"/>
    <dbReference type="STRING" id="1330021.A0A367KZ85"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI07477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="36457" checksum="DAE096DDC9B14076" modified="2018-11-07" version="1">MSTSPAFLYSALGHFNRLPYPTEDCTGRVIIVTGANTGLGLEAARHFVRLNAAKVILACRSLDKAEAARRDIEATTQRANVVESWHLDLASVASVKDFADRATSTLDRLDILVNNASVLSLKWALADGHETMITVNVISTFLLTLRLLPLLRRTGQRFNMTPHVVVVSSDAAFLPYFPERNDQSILDGLQSKEYFRERYNTSKLLQLMVMRQLARSCDASGKGHIIINSLNPGFCGTELFRDLPFPISIVFRVCLALFSRSPEKGSRTLMTAAFAGDESHGLWMTNCRLHQWPPLMDGDEGERLSEKFWHELLGVLDDFDPGVSDNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZE7</accession>
    <name>A0A367KZE7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">serine C-palmitoyltransferase</fullName>
            <ecNumber evidence="5">2.3.1.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_1662</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.50" evidence="5"/>
    <dbReference type="EMBL" id="LKCN02000026">
        <property type="protein sequence ID" value="RCI07545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZE7"/>
    <dbReference type="STRING" id="1330021.A0A367KZE7"/>
    <dbReference type="OrthoDB" id="3168162at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004758">
        <property type="term" value="F:serine C-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF2">
        <property type="entry name" value="SERINE PALMITOYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="12">
        <location>
            <begin position="156"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI07545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="548" mass="60962" checksum="48CCA18700125D71" modified="2018-11-07" version="1">MVHFAPRMPRRQPVLPRSQWKSPPTAFNSPTAMELEALHGRLHAALQQVWSAFQKVPGSAVLVRYVQSSYQNDPVRSAIELVLLLFFIRYLLSPSYSTQKQNYVKLGEDEIDELIDDWAPEPLVADRTPFEELESERLPVIVGPTGPKVKLSTGRTVTNLASYNFYNFNANEQIKEKAIQTLRTYGVGPCGPPQFYGTQDVHVKAEADIANYLGTESCIVYAQSFSTVSSVIPAFCKRGDVIVADEAVNYSIRKGLQVSRSNIKWFDHGDMDHLERVMQAVAREQAKAKRLTRRFIVTEGLFETTGDCTNLPRLVELKERYRFRIILDETWSFGVLGRTGRGLTEAQHVDPQQIDMIIGSLSGPLCAGGGFCAGPKDVVEHQRITSSAYTYSAALPAMLAMTASETVHLLQSNPDILSQCRENIKTMKAQLDPRSDWVACTSAPENPVILLVLKPDVIRTRRLSVDDQERILMECADESLANGVMIARLKTRPYAHAIAAKDGSWSAQPAIKVCVTSALSKKDIEKAGVTIRHAITKVMTRKASHKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L095</accession>
    <name>A0A367L095_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5816</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000023">
        <property type="protein sequence ID" value="RCI07848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L095"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI07848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="271" mass="29313" checksum="901B4B4AEFA012CE" modified="2018-11-07" version="1" fragment="single">AKRRGKVCVRACVRAREVASSGNATTHGVWGKKKGVDEVGGAWEESREAYVHSQTGGCMQPGSGSGSGVGRPGGMNGPFQHPYTLCYPTVNTLFCLSGEHVRKDPCCPARPDDLRQDPGHITRYISLEKQIDDGVVVMEVVKRESAKTKQKLSRLVQTCYSIPTPTSQGLKKLVPGVGKKKKKKNKKKKRLCSGLLFSPDYYDFFLTCHIIYHSIVLGPLACLRTDGPVTFGGSQSPYRKQPSSPAGRSGRKRALAGGGEGGEEHDPGELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0A5</accession>
    <name>A0A367L0A5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5892</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-10" db="EMBL/GenBank/DDBJ databases">
            <title>A genome scan of diversifying selection in the zombie-ant fungus Ophiocordyceps unilateralis complex supports a role of enterotoxins in coevolution and host-specificity.</title>
            <authorList>
                <person name="Kobmoo N."/>
                <person name="Wichadakul D."/>
                <person name="Arnamnart N."/>
                <person name="Rodriguez De La Vega R.C."/>
                <person name="Luangsa-Ard J.-J."/>
                <person name="Giraud T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000023">
        <property type="protein sequence ID" value="RCI07873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LKCN02000023">
        <property type="protein sequence ID" value="RCI07874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0A5"/>
    <dbReference type="OrthoDB" id="10469112at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI07873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="147" mass="16332" checksum="A050566123276770" modified="2018-11-07" version="1">MVAGLRFQRPTTQLDPNSSIATDKLAISSRRLAGESRMENKEFVISHDASGFWKTLPTASFPTPDHDGILRACGRAGARPLLRRCRILTEKTPNPYSVYLFALQALSRRDTIARYPIAAPGSCSAADADFSFISFFTSYFNPRRGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0D2</accession>
    <name>A0A367L0D2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_5782</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Non-catalytic component of the proteasome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000023">
        <property type="protein sequence ID" value="RCI07903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0D2"/>
    <dbReference type="STRING" id="1330021.A0A367L0D2"/>
    <dbReference type="OrthoDB" id="10248542at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03760">
        <property type="entry name" value="proteasome_beta_type_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000014">
        <property type="entry name" value="Proteasome subunit beta type-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016295">
        <property type="entry name" value="Proteasome_beta4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF6">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001213">
        <property type="entry name" value="Psome_endopept_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR001213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI07903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="282" mass="30915" checksum="0A0022F016D86A5F" modified="2018-11-07" version="1">MDHRPQAWGRPRDDIYGAYDASLVRPNGPKQATQRPIVTGTSVVAIKYRDGVVMAADNLASYGSLARFTDVKRLRPFANTSVVGFSGDVSDMQYLDRQLTDLALEEAYDEANSSGGQPSSSSSSSSSSSPPSPYSRLSAANLHRFLAKLLYARRSNFNPLWNHILVAGFDDKGDPFLAAADLLGSTYTAPSLATGFGSMLAQPIMRRHVPDEESARNLSRDDAVEIVRECIKVLFYRDARSLDRYSLAVVTKDGVELSTNEQIEDQSWAFAESIRGYGTQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0P4</accession>
    <name>A0A367L0P4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7829</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000022">
        <property type="protein sequence ID" value="RCI07998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0P4"/>
    <dbReference type="OrthoDB" id="4924937at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016809962" description="Extracellular membrane protein CFEM domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI07998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="109" mass="11294" checksum="AD456E938587DD74" modified="2018-11-07" version="1">MKFSSAAVLALAAAVSASTEMGSQLELDIGSLLQQIGPLIKKGQCAAPCIYQVVNNLNCQNGGIVDTLCNDLDEISAKVSPCVSKCGIDAGLKNTFFRISSGLCAKRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-05-03" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1M3</accession>
    <name>A0A367L1M3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_8348</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000020">
        <property type="protein sequence ID" value="RCI08297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1M3"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI08297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="88" mass="10488" checksum="4732C2EE0F635461" modified="2018-11-07" version="1" fragment="single">RNREEEEESRDSLKEAIEEELEAGEVFVLRRYFSRYFKVPTCSTLTYLYTCTYRSDRSDRSDPMTPAMTAMTRPLWPLAVLRGYMFQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1Y2</accession>
    <name>A0A367L1Y2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heat-labile enterotoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_8877</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1Y2"/>
    <dbReference type="STRING" id="1330021.A0A367L1Y2"/>
    <dbReference type="OrthoDB" id="4917004at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.210.10">
        <property type="entry name" value="Heat-Labile Enterotoxin, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017075545" evidence="2">
        <location>
            <begin position="21"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI08425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="653" mass="73314" checksum="930C440694802294" modified="2018-11-07" version="1">MRRAGLVVSLWLSCLGSASSTASSISSISRRDGESKQESVLRVYRGDTRSPQEIRAQGGFQPLGRHWSDNPQAFSIDRHFIAGISNPGLDRDSFESAYVSFSREQSSALRYGDWLYEVHALRNMLDPCNVYAYPDAEVFALGGAQWSQVVRFRWVHDQNPVWTLNTEYAELVWEKSAVGGTQTDVPKVLLDQEESNWDKAEVREAAMDYMASSDMVSALGTFPHKFEAYPPRDDIPGPRDVPQRQRKELSAEERRQREEFIDWLDVHCKRDGSVCLTSLEKLPESEGDDFPRLSEELASQDFEHLAIKYGVAEQLAKRPGKLSTSDLRGLSKGYQPLAKPTTRRVKIWGVRLFTVALLGLYTKDVVDVFSRDTSALDRAAVVTSIVPFVGCGVGAAAKAQHNQTDLADTTLCLVGDALFLTPAWPLGLVVHFSRFFLDAVRDYFYSTDRFQPETLTQRQTEGWLAYCKEVERYMHSAVFEANIRTQYMAELAAVVSRASQARAELMLGAMKLIQANPTTLGARDKIGHDMQSKKRLIEQLICVDASSTKERLRDTFIQASNRWMLNQHEQYTEHFYRELRSRAASDASTSFLQSLDAHIRAGDSVNGSVVIPTETLKSLGRAIHGHIDKLANPSPCRVTYVPSADDTLDIVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L273</accession>
    <name>A0A367L273_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Regulator of phospholipase D SRF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_8901</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L273"/>
    <dbReference type="OrthoDB" id="2589563at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037737">
        <property type="entry name" value="Srf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36819">
        <property type="entry name" value="REGULATOR OF PHOSPHOLIPASE D SRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36819:SF1">
        <property type="entry name" value="REGULATOR OF PHOSPHOLIPASE D SRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI08531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="367" mass="41282" checksum="595904C98705F5FF" modified="2018-11-07" version="1">MASSPGDRSEKPVSLRTDSIATDGAPLRLRPARSLPPWIDSYEERYGPPPDEQLRLLKPPERIVYTQRNAIPEEPQRRVSKDGFVDWDDPHLGPAKDPRAKIPHFLRYGRASMRGRKWDHLRTSEPVIISGYRPATAQASPSWKEFLHASSWGHMPNEDSQVVDYGVLKEMQPSFDGLGAAQPCLTDSKRSRRRKTLTFYKRLWIAMMRSSLSPLLFRLTVVVTSILALGVASRIFQGEDAVERDGGAAERTQSMFAVVIDCVAIPYIGYMIYDEYTGKPVGLRSGVSKIRLILLDVFFIIFKSASTALAFESIAYHRMAELQNLQLSTVLGVFELVGLMSWTMTFVVNVFRTVERLGGGVDMEDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2I4</accession>
    <name>A0A367L2I4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_4689</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2I4"/>
    <dbReference type="STRING" id="1330021.A0A367L2I4"/>
    <dbReference type="OrthoDB" id="3057599at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021840">
        <property type="entry name" value="DUF3433"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544">
        <property type="entry name" value="SPRAY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11915">
        <property type="entry name" value="DUF3433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="410"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="548"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="592"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="666"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="702"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI08641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="819" mass="89557" checksum="70907E3CBCB8CD4E" modified="2018-11-07" version="1">MSFPSFDFDQHLAALPTPGADAGARAAGRGSWSGASRVANCCSPGSHSPFSSSPPAFPASWRPSHEPGLQNPWQTTSCLHAEAGSSSIRPQPFPPILGERHVAPHSLEDFDEAELSMAAATNAARLGLLKDELSVIAGKITPGVDDTPYIQFALEALTREPGSHPGANAPEGGWTNARQPHVPLDEGRMLAPVTQPEPVRYLHQGASHGEPAQVDVPEQGRSPLTTTGAHLQHWIAVDRNTLQTIDPRGSTYPPLTFKPRILRPLSTAALLILCLLMMTAYVFSNRYAQHNLGLTPYPGSIYSGQYFVFRILPPLVAVIILIYSQCILTTSLRILPFTNMAQEDPRERYLALFQRLYPRTFLLPQLMGPWQLIVFDFATWLAILTVPLQSSAFTCIYVRDEWIWAPSQGVAWALVGLYALLGASTAIVTVFWLRQWTGLRWDVRSIADVVTLVSRTNTMHSYTRQTVLESRSDFKTELRDRWFDRLGYWQTGNVMAGGIWHTIGTTAMAPGGQGDTDHGRRESCEVSMASRDLALWGGRHLPLSLRDWPLVGSVLVTGGLLVALLIVCFLPQTRLDAGFLPLIPAGPNQSAFSAANFVYSFVPALLGMVMFLLFQSVDLSVRMVQPWGSMAGAEGASARRSILADYSACLPLQSTWRALGNGHWRAAVTSMMAVLSAAIPVLAGGLFMALTSPDGRVRMFPSMPVLGVLLALVVLYVGNLCLLVPRRRQFLLPHAVESVAAMVSLCSAEATVGEAAWRMASSRSDLAARLGVRKGDEGEESVWFFGLLPGKDEQRPSVRRWRRFTEKGGREGAWTGRMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2P4</accession>
    <name>A0A367L2P4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_4832</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2P4"/>
    <dbReference type="OrthoDB" id="5001282at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI08701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="78" mass="9278" checksum="A251408A09C2B6AC" modified="2018-11-07" version="1">MLLLRKIKEEILDTTLLEYFISRFLGPRERSTIAIKLKVPRVTYILAKLAYPQGYFFKQLIEVYCPKYYRAIIIAVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L309</accession>
    <name>A0A367L309_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_4844</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L309"/>
    <dbReference type="STRING" id="1330021.A0A367L309"/>
    <dbReference type="OrthoDB" id="18234at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="143"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI08820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="31110" checksum="3EEE78AE63E60558" modified="2018-11-07" version="1">MGAKTGAALKSFQWLLRALQFLCAAFILAVFSFFLYTLRTNNLPIDNTFRAVEGISGAAALYTIFAMLLVCCIGGQLYAAIAAAALDLGFIGAFIYVAVVNKGGLGSCTRLSDTLFGQSLGPNEAALDAEQQDGLPGVQTACMLSVGCFGVAIAIIVLFVFSALMEVALARHHRKEHRFGPSPANNYTSGYGSKKSAFLNRFRFFRRKRDQDLNTLPEHTHPDQLDRSRGSYGTETTAIGHATDNPKQEVHAYQPSVANYPSGWHTAPQVHNPPAGYSYNDGLYDRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L337</accession>
    <name>A0A367L337_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L337"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="78" mass="7884" checksum="910E8FD2F1F279CC" modified="2018-11-07" version="1" fragment="single">KFDCLDRPPFLGSLTYPTFLPSYGPYGPYGRSRSSVTYGGLGPAAAGPASPSVTYGGLGPAAAGPASRDPPRPSGRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L355</accession>
    <name>A0A367L355_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L355"/>
    <dbReference type="OrthoDB" id="4928220at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="103"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="397" mass="42962" checksum="85DB651025951C67" modified="2018-11-07" version="1">MSTRKRSDLHQEARPSPSQSKSDPPKTPKPPTVEQGQSSPSKGDERPQLGQGQGQPSATGSEKLQPTNKRDFSDLERPAKGGKRRVKLKVGPAIQSSTDAFGKQQPAAKQASSQEQMSRPTVQKPLPAVQTTGQTRQPMIQAPQPMAQTRLPMMQTPQGILQAPWPMAHMPQPMAQPMAQAPWPMAQNSLPAANEARYPAPASSAPPVFKKNMSFASLKPQFPDKPPTTFSNTPSATLPPPPTAQTSNSMAGAVGSITPTELPSASEQQRKTLIKLRATQLLVESGLAVSHSTLTLTDLVHAERIVFHLWMRIGQTCTLPTLVINQLGRTELAGYNAGKKHPFETFHPLSYPFHPASMGRTDSIKEEDSEETLFYTATLNTTLEPAATHCHGSQASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3J7</accession>
    <name>A0A367L3J7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_4940</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI09006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3J7"/>
    <dbReference type="STRING" id="1330021.A0A367L3J7"/>
    <dbReference type="OrthoDB" id="5376590at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.100:FF:000005">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 64 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054585">
        <property type="entry name" value="NDH2-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF50">
        <property type="entry name" value="NADH DEHYDROGENASE (UBIQUINONE)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22366">
        <property type="entry name" value="NDH2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="511"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI09006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="666" mass="74523" checksum="F6DE9DC28E886FB4" modified="2018-11-07" version="1">MRAIVPLRRPQLALLLPRVQPLRAGVVVQSQCRSTTTQGRRRQPVGVFVRNISGKPLPLKRSWMYNFCYRAAAWVGTSIAVVGGCVVAFFVYDATTYKHGAELGDIDVSQLALQPRRGGPKNLPVAEAFIDDDETKKNTKPRLVILGGGWGGVALLKELDPEDYDVTVISPRNYFLFTPMLPSATVGTLELRCLIEPIRRIINRVHGRFIYAKAEDVVFSERLIEVSQLDSAGQETRFYVPYDKLVIAVGSVTNPHGVKGLNNAFFLKDVDDSRKIRGRVIRNLELACLPTTSDEERRRLLSFVICGGGPTGVEVAAELFDLLNEDLTRMFPRLLRNEISVHLIQSRSHILNTYDETVSHYAEKRFARDQVEVLTNSRVKEVLPDKIVFTQKHADGSLVTKELPAGFCLWSTGVSPTGLCQKLAQKLGDFQPNRHALETDTHLRVSGTPLGDVYAIGDCATVQNNVTDHVISFLRAYAWKRGKDPETLQLSFNDWQHVARDVKKRFPQAVNHLRRLDKLFSEFDKDESGTLDLGELRELLSQIDNKLTSLPATAQRAHQQGSYLAHKLHKLARLSDGLSVNDVRDGDVDAAAYRAFEYRHLGSLAYLGNAAVFDLGRGGWSLAGGLWAVYAWRSVYFAQSVSFRTRSLMAMDWAKRALFGRDFASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3M1</accession>
    <name>A0A367L3M1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Uridine kinase</fullName>
            <ecNumber evidence="7">2.7.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_4941</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>cytidine + ATP = CMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>uridine + ATP = UMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16825"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="7">Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the uridine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.48" evidence="7"/>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI09007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3M1"/>
    <dbReference type="STRING" id="1330021.A0A367L3M1"/>
    <dbReference type="OrthoDB" id="738517at2759"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00637"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00579">
        <property type="reaction ID" value="UER00640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043771">
        <property type="term" value="F:cytidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004849">
        <property type="term" value="F:uridine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044211">
        <property type="term" value="P:CTP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02023">
        <property type="entry name" value="UMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002070">
        <property type="entry name" value="Uridine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000010">
        <property type="entry name" value="Uridine-cytidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000764">
        <property type="entry name" value="Uridine_kinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004018">
        <property type="entry name" value="PRK05480.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00235">
        <property type="entry name" value="udk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00988">
        <property type="entry name" value="URIDINKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribulokinase/uridine kinase" evidence="8">
        <location>
            <begin position="25"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="9">
        <location>
            <begin position="257"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI09007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="452" mass="51386" checksum="916BDBE2D5557679" modified="2018-11-07" version="1">MSQLESHASVQKRVYYAPPWADVSIVGIAGSSGSGKSTLSQAIVKRLNLPWVVILSMDSFYKSLNSEQLRLAFANEYDFDSPEAIDFDALIDRLRDLKAGKRAEIPVYSFTQHQRLDQTTSIYSPHVLILEGIFALYDPRVLELLDIGIYCEADVDTCLSRRIVRDVRERGRDIEGSIKQWFGFVKPNYEKYVEPQRKVADLIVPRGIENQVALDMMIHFIEKKLFEKSTHHREALTQLQVACKEQPFSDRVSLLNDTPQMRFMNTILQDIDTSAEDFIFYFDRLAALIIEQALNKVQFTSVEIETPTGSKYQGLRPKGEVCAVIVLRGGSAFESALRKTIPDCRTGRLLIQSDFSTGEPELHYLRLPEDIHKQESVLLLDTQMASGGAALMAVQVLVDHGVELERIVLATYSAGRLGLHRLMTVFPEITVVVCNMLADQEQRWVEKRYFRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3Q4</accession>
    <name>A0A367L3Q4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_4939</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI09038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3Q4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI09038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="107" mass="11506" checksum="E227FA83A9F86F06" modified="2018-11-07" version="1">MSVPSLSFQARSSHHWLLPLNSPNGRLSPFRTVPLLPPPPARAPLTACHCHANLNNRGHPVPLSIPVRTGDTPHLLPALAKTFSSSSLSLSQNTTHPFFIKGPNSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3R9</accession>
    <name>A0A367L3R9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">S-(hydroxymethyl)glutathione dehydrogenase</fullName>
            <ecNumber evidence="12">1.1.1.284</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_5128</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>S-(hydroxymethyl)glutathione + NAD(+) = S-formylglutathione + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19985"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-(hydroxymethyl)glutathione + NADP(+) = S-formylglutathione + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19981"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58758"/>
            <dbReference type="EC" id="1.1.1.284"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>S-nitrosoglutathione + NADH + H(+) = S-(hydroxysulfenamide)glutathione + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:78371"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:145544"/>
            <dbReference type="ChEBI" id="CHEBI:229723"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a primary alcohol + NAD(+) = an aldehyde + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10736"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a secondary alcohol + NAD(+) = a ketone + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10740"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17087"/>
            <dbReference type="ChEBI" id="CHEBI:35681"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.284" evidence="12"/>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI09076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3R9"/>
    <dbReference type="STRING" id="1330021.A0A367L3R9"/>
    <dbReference type="OrthoDB" id="417550at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106322">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106321">
        <property type="term" value="F:S-(hydroxymethyl)glutathione dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080007">
        <property type="term" value="F:S-nitrosoglutathione reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08300">
        <property type="entry name" value="alcohol_DH_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000003">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.180.10:FF:000001">
        <property type="entry name" value="S-(hydroxymethyl)glutathione dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014183">
        <property type="entry name" value="ADH_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02818">
        <property type="entry name" value="adh_III_F_hyde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43880:SF12">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE CLASS-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="13">
        <location>
            <begin position="20"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI09076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="382" mass="40690" checksum="69D8A9F8091DBD15" modified="2018-11-07" version="1">MASTAGKTITCKAAVAWEAGKELSIEDIEVAPPGPHEVRIEIVYTGVCHTDAYTLSGKDPEGAFPVVLGHEGAGIVESVGEGVTDVKPGDHVVALYTPECKECRFCKSGKTNLCGKIRATQGKGVMPDSTTRFRCRGKELLHYMGTSTFSQFTVVADISVVAVQPDAPMDRTCLLGCGVTTGYGAARVTANVEAGSSVAIFGVGCVGLSVIQGAVINKADKIIAVDVNPDKEAWARKFGATDFVNPNDLSEGETVVDRLIKMTDGGCDYTFDCTGNVNVMRSALEACMKGWGQSIIIGVAAAGQEISTRPFQLVTGRVWKGCAFGGIKGRSQMKDLVSDYLKGTLKVDEFITHRYKLNEINNAFDAMKSGDCIRCVIDMRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4I4</accession>
    <name>A0A367L4I4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L249_1387</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367L4I4"/>
    <dbReference type="OrthoDB" id="5575062at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000481">
        <property type="entry name" value="Structural maintenance of chromosomes 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000585">
        <property type="entry name" value="Structural maintenance of chromosomes 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF172">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="14">
        <location>
            <begin position="742"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="958"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1175"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="410"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="463"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="621"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="1259"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1190"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1213"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1235"/>
            <end position="1244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCI09321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1485" mass="165308" checksum="1926DC8A29FAD161" modified="2018-11-07" version="1">MSEATPSRPSRRVATRRTAIIDSDSDSDSATAAAEAEDEFTPQPAKATRRQTTRGPRTSIAPTVTAAAAPRTRGRPRKVTAPVAVPPSDAQDPDETAQPSAEDSLINFSPRKRKSAAPRASVAAATGSDLAPPTPKPSTSPEPSRILATPLADVTATRGNTQNPDTTAAAAAIKPVKPFDTVMDRPMDIMLKQRTAAVPVVEEVAESKPRIVLTYLILHNFKSYAGRQEVGPFHASFSSVVGPNGSGKSNVIDSLLFVFGFRASKMRQGKISALIHNSAQHPNLDFCEVQVHFEEVMDKPGGGHEVVPDSGLVISRKAFRNNSSKYLINGKESNFTTVTTLLRERGVDLDHKRFLILQGEVESIAQMKAKAANEHEDGLLEYLEDIIGTSKYKTPIEEAAAEVETLNDVCVEKSGRVQHVEKEKQSLEDKKNEALDYVRDENELVMKKSSLYQLYIHECNDNMSVTQEAATQLQAQLQEELEKHHGSEQIIEELQKQYAAGSKDHATREKRSLALAKDLAKLDQERVKLDEKRKFLEDKKKKLDKTIGNAEKSTVEAQETMEQCSLDIETRTREVAALEEQVKSEEAELAKIRDSLKGKTQAFSDQIAAKLKSLEPWTEKINQKQSAIAVAESESNILREKANAGAVALEELQAKMKAIEEGKAAKEEELRACEAEKESLQKQADKMTSELQVLSENEPKLRSKISNARQKADEARSSLASVQTRGNVLTALMRMKESGRIDGFHGRLGNLGTMDPKYDVAVSTACPSLDNFVTQTVEAGQQCIEYLRKNNLGRGNFICLDKLRVRDMSTLDTPEGAPRLFDLVRAKADEFRPAFYHAMQDTLVADDLAQANRIAYGAKRWRVVTLQGELIDKSGTMSGGGSTVKKGLMSSKLVADTSQEQVTKLEDDRDAWETKFREFQEYQRDCERRLGELREEIPQLDTKMQKLGLEVESARRNEADVQRRIDDVGKEHQPSDDDSRRLKALQKEVAKLKGEIDQLRGETASVEAEIKTLQDGIMEVGGERLQAQRAKVDALKGEMASHNEETSGAEVRRAKAEKQTAKLAKDVAKASHERDAAADELERLEADMDRQGGKAEELKTRLQEAREGLEAKKEELSEFKEALDAKTAELNESRAVEIEMRNKLEENQKVLAENDKRLRYWNDKLSKLALQDVEDLTGTGTAAPVKAREDGEEEEEEEEEERQGETTTTMMMMDEDVDMTDAPPDEQEEDDETASTKGQQSQPQELAKYTPDELAGMSKETLKGEIAALEEKTQKVNVDLGVLAEYRRRVEEHAARSSDLQTAICQRDAAKKRCDDLRRLRLEGFMTGFSAISLRLKEMYQMITMGGNAELELVDSLDPFSEGILFSVMPPKKSWKNIGNLSGGEKTLSSLALVFALHHYKPTPLYVMDEIDAALDFRNVSIVANYIKERTKNAQFIVISLRNNMFELAARLVGVYKVNHMTKNVTIDNRDYISRNTGQVTLPIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4J2</accession>
    <name>A0A367L4J2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fucose-specific lectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_1411</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4J2"/>
    <dbReference type="OrthoDB" id="4896939at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.70">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89372">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI09328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="518" mass="55955" checksum="DCBB98E7EC50CDE9" modified="2018-11-07" version="1">MPLDIPFLLQREQKMSSPSVDPWKTSSLGNSGVGPPPNPEIIHNHYYATAPKPLPWYRRKRFSWTAIAALVFVAVASAVTLGVVLKFQVGKGRLRDAGVSVDDENSSSQLTDQGTPSSSTTSHLSQSTVLASTSGSPHDALSPASSTPPSETTAHSNSAWATVSFPSSASTSMAASETQMVVYTVSEESHLASVYLDNEEEKLRRRLLVWQDQKRHLMVTDWSGGNKTHYRLRDQLRSSIPDAKLGTPLAMAGSSSGAVDLFFLDTQNTLSHVFQTAAGLWERSSLSKGNGPIVASDPSPLSAAWHRIKNGMEVLTVAYASSEKMRLAMTDRPTSDSNWLTVDVTSLPGPVPGQEEKARFAVAGDWQTKAGSQPMLMAVLKEDGLVAYECFIDTWPPESSTPCRETSGTLQDGEGRDAVSAPKQLGWIRLDGSPDGYGFSLLSLGEDGFIGEDRVGAGLRRKAGRGLDTKMAVRAISATDEAVLFAAAGDDVHIYRRKTEDGTWQAEGQLMPGRRWEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4P2</accession>
    <name>A0A367L4P2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Methionine aminopeptidase 2</fullName>
            <shortName evidence="9">MAP 2</shortName>
            <shortName evidence="9">MetAP 2</shortName>
            <ecNumber evidence="9">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_1487</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9 10">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="9"/>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4P2"/>
    <dbReference type="STRING" id="1330021.A0A367L4P2"/>
    <dbReference type="OrthoDB" id="7848262at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01088">
        <property type="entry name" value="MetAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03175">
        <property type="entry name" value="MetAP_2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050247">
        <property type="entry name" value="Met_Aminopeptidase_Type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002468">
        <property type="entry name" value="Pept_M24A_MAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018349">
        <property type="entry name" value="Pept_M24A_MAP2_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00501">
        <property type="entry name" value="met_pdase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777:SF2">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01202">
        <property type="entry name" value="MAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="12">
        <location>
            <begin position="133"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI09182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="448" mass="48599" checksum="4047448F9368040E" modified="2018-11-07" version="1">MAAQIPTEAMKGLNVADHKGAKPTTGGSGAGGGAGGDESEDDSGDEHGEDGGEGEAAGSSKKKKKRKPRKKKKKNNNPTSQTEPPRVQVSQLFPNGSYPVGEEVEYVDENRYRTTSEEKRHLDNMNSDFLTDYREAAEIHRQVRQYAQKVVRPGQTLTSIAETIEDGVRALTGHDGLAEGDALKAGMGFPCGLSLNHCAAHYTPNAGNKMVLQQSDVMKVDFGVHVNGRIVDSAFTMAFEPQYDNLLKAVREATNAGIGEAGIDARVGEIGAVIQETMESYEVEIGGVTYPVKSIRNLTGHTILPYSIHGTKAVPIVKSNDQTKMEEGDVFAIETFGSTGNGYVRDDGEVSHYARNGDAQHVDLRLSSAKSLLGVINKNFGTLPFCRRYIDRLGQEKYLLGLNSLVNSGIVESYPPLCDKKGCYTAQFEHTILIRPTVKEVISRGEDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4T5</accession>
    <name>A0A367L4T5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-grasp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_3718</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000015">
        <property type="protein sequence ID" value="RCI09445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4T5"/>
    <dbReference type="OrthoDB" id="434648at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052032">
        <property type="entry name" value="ATP-dep_AA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041472">
        <property type="entry name" value="BL00235/CARNS1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43585:SF2">
        <property type="entry name" value="ATP-GRASP ENZYME FSQD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43585">
        <property type="entry name" value="FUMIPYRROLE BIOSYNTHESIS PROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18130">
        <property type="entry name" value="ATPgrasp_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-grasp" evidence="6">
        <location>
            <begin position="634"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="806"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="809"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI09445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1091" mass="118685" checksum="886F64BE1208919E" modified="2018-11-07" version="1">MNCWKLKRDDPCLAPFGKAAGKFQRDSKQNSLGSQSDALPDGVLTLHVSNLDGDGSGTRVHIISISLQGRETLTLATVIELADKTTSNPPPHSLGRSMGIGTSASHAAPPFREVAPFRSVIDGGVDLRNGPHLRAEKSWLFNGSCRIELIDVADYAEEGEDCWAEAVQGPDTPSGWLGLDLEQGNGLNDCVVDRSGSEAGRGISSMDPIVLVRCHASIIQIFTGQRSQEGKRDRERKKAAPSANHSPSAIHVQAPLTPLRTRVHPPSPAYIPQRRNHEPMIQATRGEIANDAPLGGGGRASINESIINIITFQHLISDSIDPVVCIMAAAAAAAAAVNRPVLGSTSLDLPSIMTFRRGVFATEKGIFRCMWEDVNLNHWVNLVHITIEAAGETTDNVVLVPDGCRLAGMMDKAVNSTAVFSLILPTVGGYVSKADFVHVRLQGCQGLLSVVDYFEPLAWYGPPEQSLTSFGLVDLVDKAFSVVRWVVPFSDSLRLTNVLRPRLNFHWLSPEPVARKRLALVGGRRHFLAARAILDAAGTLGIDLVVVDAQGHWLQPDTDENRRHREAFIAIDLTDDDGLTERITGALLEYPKPVDGVFTHNDDFFVAVARVAALLGLPTCPVSALETTSDKYKSRMLQDEPGRTARVSSLAELRALMEQSTFNPVFPLIVKPTKGWASQCVSKVTTLQDLPVAVHKAIGRHGSPAVIEPFFDGPEVDVNLVLLDGEILFSEVTDEPPCEADAQGASVDATFTSETMSIPSALPFDELEAAKETMRNILVDIGCHTGVFHAEARMVNSSVEYGRVSGVGDDAHNVDDRSSDVDASGESVNTEDFDRGLDFLNQRGDFSRHDTAVSDLLGQSDLVVRPDSAQQPDVVDPDVARQSDQTDIVVPNVFVPDLANQSDIVTPDLGQQSKPDRLNLIDLMPKPDDRLPETQVECRLLEINARPPGFSVSRPTRYVHGIDYFAIDMLAALGEHDRLRRAAIPFDFSLAPPARGVPTAQCWSQLVCISAPAAGVVHSDSPCEELKRLNPDLAGHIILVNEYFRKGDRVELYKDGVRVRVADICVISPRSRREVVELGEKVRSGYRIDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4W1</accession>
    <name>A0A367L4W1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000015">
        <property type="protein sequence ID" value="RCI09460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4W1"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="96" mass="10392" checksum="85B364EEBE380654" modified="2018-11-07" version="1" fragment="single">HNAYSGVGSIRSIGLTRTSLPPNHRSSKYVRVLQVGTLKYLEKIISISFSHLLNTNTSPASNSSSIASFRPSRDSSSSSLSRDHLPDSSTLHPLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L527</accession>
    <name>A0A367L527_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cenp-O kinetochore centromere component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_3945</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CENP-O/MCM21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L527"/>
    <dbReference type="STRING" id="1330021.A0A367L527"/>
    <dbReference type="OrthoDB" id="10050372at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031511">
        <property type="term" value="C:Mis6-Sim4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018464">
        <property type="entry name" value="CENP-O"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14582:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14582">
        <property type="entry name" value="INNER KINETOCHORE SUBUNIT MAL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09496">
        <property type="entry name" value="CENP-O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="3"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI09517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="292" mass="32259" checksum="79BD61750D7BD633" modified="2018-11-07" version="1">MEADSALADAVPLEQELQDLRNQAIALRKELQIQCSTILASSMGIRAAAAASSSSSSSSSASTDLATRASHQRAYMQRSNYRASAPVTAFKVQDPDPCAVDGGKVLGLRFEAMSRGQFHRPYYVMLNRPYDHSPRHLKLHRHTLPPTVAVNALAARYLPHPSGGQQQHLERFVAELRRDIVRYHNRMGVAADLRRKLGLHHRRASSANHSVVEVVIADIEAKHVKIGWADGRSGRLVLDHDGCVRNLVVFDHQGRDWDTAVQLMGSGKDGLQDLAARLQPRDVDRPGKRHSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6B6</accession>
    <name>A0A367L6B6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_8636</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI09967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6B6"/>
    <dbReference type="STRING" id="1330021.A0A367L6B6"/>
    <dbReference type="OrthoDB" id="5032844at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="411"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI09967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="598" mass="65413" checksum="F284C6F0990CD888" modified="2018-11-07" version="1">MFPMRPADDANLRSLTDEDQQLLFRLIQRYGIPSLLCALTGSPDSSASSTLSAGTLLSNVSAPSLAWTSSAASQCRSDDASIHTQCTWPDVTASDMHDNKISERSWLDSPGPVPSPLPPPGDITSHPSPQLAAPTSKKYQCPMCFLDNSPVGFGRKSDFKKHLHNFHGADVVWICRTKGCQLSFSTERAYSTHAKEAHRMKALPNSAARTELCAQVVFSCGFAACRDRIFEARNADESSATRDKHFEHIAKHFEEGFDVRHWEYRVQMQNLMRQPQVKPTWKTCIWPKEKRQQLLWRPRSSGDLKRILECRHLGGDIPQLVRLAYILGTPPFTSPATPPMSDVEVYFQLPYRSSCLVNAPGHTAVSVGSPKTEDDSSAAAAAVVPKRRSSRSSLTQSVFRLSGRQGKRASRPVTPSSVPTPTSAPRAPTPCTPIEDTIMGSGEDDDDDDDDDDDAAAATGPHPGTPFPIPSDVVWPPDAPKFAPEAPSGLPKHLNTPVDEAAMLYSPMHMEHSAQASWCGIDAFDPYSPQMGLPQGIYDYATTTTTTTTTTTAPRPATPVPHKRPASWGRVVSMETLRPAKKTTMPADQELLPTMLSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6V2</accession>
    <name>A0A367L6V2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_8389</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6V2"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI10138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="74" mass="8291" checksum="4551E9CF6A953AA0" modified="2018-11-07" version="1">MQRSAKGYLRPYNRGDIYDKGRDLCDVQMPFPLIYLDRGRRLKIAAAAEAVEAEAEVAEAAALKAEDPLLLRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6V8</accession>
    <name>A0A367L6V8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="9">2.1.1.205</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">2'-O-ribose RNA methyltransferase TRM7 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L249_8628</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>cytidine(32)/guanosine(34) in tRNA + 2 S-adenosyl-L-methionine = 2'-O-methylcytidine(32)/2'-O-methylguanosine(34) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42396"/>
            <dbReference type="Rhea" id="RHEA-COMP:10246"/>
            <dbReference type="Rhea" id="RHEA-COMP:10247"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74445"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.205"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.205" evidence="9"/>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367L6V8"/>
    <dbReference type="OrthoDB" id="294853at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106340">
        <property type="term" value="F:tRNA (guanosine(34)-2'-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002128">
        <property type="term" value="P:tRNA nucleoside ribose methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03162">
        <property type="entry name" value="RNA_methyltr_E_TRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032629">
        <property type="entry name" value="DCB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032817">
        <property type="entry name" value="Mon2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028590">
        <property type="entry name" value="RNA_methyltr_E_TRM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF12">
        <property type="entry name" value="TRNA (CYTIDINE(32)_GUANOSINE(34)-2'-O)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16213">
        <property type="entry name" value="DCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16206">
        <property type="entry name" value="Mon2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <keyword evidence="6 9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Mon2/Sec7/BIG1-like dimerisation and cyclophilin-binding" evidence="15">
        <location>
            <begin position="4"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2/Sec7/BIG1-like HUS" evidence="13">
        <location>
            <begin position="199"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Mon2 C-terminal" evidence="14">
        <location>
            <begin position="1029"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="12">
        <location>
            <begin position="1720"/>
            <end position="1856"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="12">
        <location>
            <begin position="1865"/>
            <end position="2005"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="476"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="646"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="650"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="1962"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="1752"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="1754"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="1872"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="1888"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="1922"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCI10166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="2096" mass="226737" checksum="9C3E7E93B78DA09D" modified="2018-11-07" version="1">MTTQLLSSELANLIQESKRKHNDLRQAADKSLEELKQLGILPEPAAAEQLSRRPAFVNPFIIACGTKNAKFTGIAIVCLQRLIVACALPPSKLGQVVDALTQASSAGLDVQLKILQALPSLLQNYAANLQGNLLVAVLDVCFSLQSSKNAIVNNTAAATLQQLVVSVFDKAVAEDNASDAPMVGEAPSAAGPVELRAAALDAYRIFSDLCLMTENQRPEFLRSSGLPQTFGLELIESVITNHAAVFATHPEQAEILRVRVMPLVISALKGKPAFPTCVRLVRILFTILRRHVSILPKECGEALDILTQLLDQDSPLWKRALCMEVFRGIFAEHALVRRIYSLYDAMAGERDTLKGLLATFVRLGTEKPAVIGLGHQSTIPASDPANASVATSDQAMLEASGMAGIIGGGSLGSEGHSTGISVRSSSVRVSCIDQLDKTEPPAIPESYIYGLVLTCLSSLSDGLAKFILPLTVPGDGRSRKKTHAKPDRPTDSPASIQSAVDSPFSKGSGRDRSVSSTFKKNPVPLNPLDMEDHPLYAEVKTCASMVEECWPAILATCSTFLYASLDQEYYHGLVRAFQRFAHVAGLLHLSTPRDAFLTTLGKSAVPPNVLSVCYGPSLSRLTASSPQTEVMANTLFNNARGLLGVDGGATPSSPSSERQRQASVDATTAPTLNTRNLLCLRALLNLGIALGPTLGHAWSIILETLQQADFVLFSTGKAPGRTPSIGRGPDSAEHESTSLMSNFTSEVRAVEIAASRLAESTIDFPNTSFVEVVEAVCVLVEAKPSDEFRRSSAAHVPPAVTAAAAIPAVDELSRSRPDAHRRVQSFSGQASSAPAQEYLFALNKLGEIANINLERLLGSDPDASGWHRLTRELISILSSSTMAPPVRTKAAEILSRLLLDAASAAAVMPDEEGDDVRGATQLRVLVALRDAITPLLEHARGSSVANQMTDVGVHDIILEGLKSIIEGCGESLVCGWDRAFEIIGSVFESERSVPGEKEELLSARVGILTTRSSKLVRSSFGSLQLICSDFLSSLPKACFLILVDTLYKFCSQDDDLNIALTTINFFWVLSDFLSTKEESLDITVELARQGDHENGLEELAADGEQKGSDAALWMLLLLRLTAVTTDERLELRNSAIQTLLRIFDAYGDRLGAEAWSACVESVIFRLLSSLESELEAAEDDDVAEWHGTCVIVINGISDLLGNYLDVLTTHEAFSRLWRELHGHMAKLLDFQVLDVSTAVFKALTHIMSRVREAEKTTLSEASVECVWDLWSRRIPTSKRVAMDAGSKAENNQNCLIAFVAALSELYHLVENGLTIERVGRMLTLLQETVEASEGSYMADVESTTPLQTHVLEAVQMIRTDVDGVPSVVIRQVSGFVTMAFEQDRAKSDARGSPKRTFVAMSKASMTMLKTLISRHATTLDVYTSGAVASALSALCSPIKLKYGFHTVTKSAQPWRLATTAALEVMEATLPRLDSLSIPRETTRAIWAEAVSVAGGILGADTDGMPVGTNLADDEEFDMASMSKLRQLVIPSLGGDAVGDETRKAYAESLLKTSIVHPLTASESSLVDDDKGDDAELASLYGPRPGRTAAKTPTRRARVAYVALDELFSLVSAVDRQCSRRALRLRIASTAAPLLVLRCALTIRGYAADQPLRGKMPQPLSQRRELVWMLRKLVALRKVHRQEAFFSPPASLPTSPSFFVMGKSSKDKRDAYYRLAKEQGWRARSAFKLLQLDEEFDLFSGVRRVVDLCAAPGSWSQVLSRVLVQGERFGHRAWRDGEARLRQQMLGIADKGRARRQDRAIDLQPMAPLPGITTLRADITHPTTVPLLLSALDANDEDAEAENSRVDLVLSDGAPDTARPTKAVPDVKIVAIDLQPMAPLPGITTLRADITHPTTVPLLLSALDANDEDAEAENSRVDLVLSDGAPDVTGLHDLDMYVQSRLLLAALNLALCVLRPGGNFVAKIFRGRDVDLLYGQLSVFFDRVVVAKPRSSRGSSVEAFVVCLGFRPPVGFRASLDRPLEVRGGDNDVEVEDGDDAAAAASETRWIAPFVACGDLSAFDSDASYRLPEHHVSLDPVQPPIAPPYKRAMEMRAAQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L719</accession>
    <name>A0A367L719_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_8720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L719"/>
    <dbReference type="STRING" id="1330021.A0A367L719"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000050">
        <property type="entry name" value="GTPase activating protein (Gyp3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="505"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="562"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="803"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="396"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="806"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="822"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="835"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI10223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="855" mass="94038" checksum="BD8A8ED3CEDAFD1A" modified="2018-11-07" version="1">MYSMAVSRFDNGGSVERQRSLRNRQCSVYASRIRPSVSPIAVHGSDPQAAVQLPPLPVSPRWDSLSNGSHLILSSPTSTDEGWSEQPQVAAESSSASSAASTSSSSSTSLAERRGNAPPDVLLKTNYNDNKTKVDVRSPHEVENFSRPRKQSLRQPTEQSAPVPRLLANVFARARNGYGPPLTAAARAPLASSSSPMAVGGAPPPPWMAGDGRSSFRSQLTESSAFGTAVTERSSVLTKNSSVTSLYTDEPSLEDVMCMYEKGFADDDDDDDDDENEDDEDDDDDDDDLDIDGDSDTNRQVIVNSVVTVASDPSDSATSIADLPRPATAMSAPAEGRNVDDGYLAPPVPPTTRSALDAEIRQSKMLFTSPAFTASVPALSAAADLDVAEKRDSAKSLDSVPSMSSSDRMPPAEAKISPLPPSPTSLFRAAMEPEDPGSRDRYGFKKQNQSITREQYDAWNKDYTQYLARRHKKWVAYLAECGLMTDRPIRFPPPSAKTKRFVRKGIPPDWRGAAWFYYAGGPAILARHSGLYEKLLEREAKPVDVEAIERDLHRTFPDNIQFQSSPPSCPPDHSNGPSTDEPPIVSSLRRVLHAFAVYNPRIGYCQSLNFLAGLLLLFVETEEQCFWLLNVITIIYLPGTHEMSLEGSKVDLGVLMTELRDTMPAVWDKIGGELEAGSRAAAGGKAARKARPTLWRRDQPRLSTERLPPITLCMTAWFMSCYIGTLPMETTLRVWDVFFYEGSKTLFRIALAIFKSGEAEIKAVSDPMEMFGVVQALPRRMLDANGLMETCFKRRNGFGHLSQDAIDERRQERRDKAHQDRTAATPEAEEPAGGTRRKGTLFGRRRREASRTRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L736</accession>
    <name>A0A367L736_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mandelate racemase/muconate lactonizing enzyme C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_8537</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L736"/>
    <dbReference type="STRING" id="1330021.A0A367L736"/>
    <dbReference type="OrthoDB" id="14161at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050023">
        <property type="term" value="F:L-fuconate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.120:FF:000007">
        <property type="entry name" value="Mitochondrial enolase superfamily member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034610">
        <property type="entry name" value="L-fuconate_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046945">
        <property type="entry name" value="RHMD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794">
        <property type="entry name" value="ENOLASE SUPERFAMILY, MANDELATE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794:SF58">
        <property type="entry name" value="MITOCHONDRIAL ENOLASE SUPERFAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00111">
        <property type="entry name" value="L-fuconate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00270">
        <property type="entry name" value="L-galactonate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00179">
        <property type="entry name" value="mandelate_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00909">
        <property type="entry name" value="MR_MLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mandelate racemase/muconate lactonizing enzyme C-terminal" evidence="5">
        <location>
            <begin position="201"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI10231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="451" mass="50207" checksum="40E5B214CC1288C3" modified="2018-11-07" version="1">MTSEITITGFTSRDVRFPTSLDGTGSDAMNVAGDYSAAYCILETDSPLSGHGMTFTIGRGNDLVCAAIVHVAERVRRKSLAELTAHWGRTWRYLVSDSQLRWIGPEKGVIHLALGAVVNAIWDLWAKSLGKPVWRLVADMTPEQLVDCIDFRYITDALTKDEALAILRARQASKQTRLQEALDSRAVPAYTTSAGWLGYDEDRMRQLLRESLAQGYKHFKLKVGGSVDEDRRRLTIARDVIGYDRGNVLMVDANQVWSVPEAIEHIRCLCDFRPWFIEEPTSPDDIIGHRAIREALKPLGIGVATGEMAHSRVMFKQLLMTGAIDVCQVDACRLGGVNEVLAVLLMAAKYGVPVVPHSGGVGLPEYTQHIATIDYVVVSGERSLLEYVDHLHEHFLHPSVVKDGFYQTPLEPGYSVEMKPESMDKFAFPGEEGVSWWRSDEAKPILKGRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L759</accession>
    <name>A0A367L759_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8763</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="280" mass="31482" checksum="9ED108694309F3F9" modified="2018-11-07" version="1" fragment="single">KQTIKRFSGSARHSYTHTQGTRPEGLGGSRDAGPAAADPRPPYVIEAHNNVGGGYGYGYGYSCTGRTGRTREGTAIAVAAAAAAAAAADLEGLFNYRLLRRGEDEGPALADLETFFLPIAGELTADSTLFFFDLYSRYGYGYSYSRRPYCYTGPIAYSDNRNRVRIRVRIRIRIRIRNEINSGIRVRAGNSSYNSHRNSYYNNSYYDSRYNNRNNSSIRTYLWPYRTYAPYSRYLRPRIRTWPEGLGGSRNAGPAAADPRPPYVTKALYGPYRPYEGRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L803</accession>
    <name>A0A367L803_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_4481</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L803"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI10549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="74" mass="8469" checksum="75D65C0E40383A3A" modified="2018-11-07" version="1">MRYNVLVRASRRELIIYSIDNLFLTTSLREILLVLYITPTPKAPPIISLLSKVSNFANFFSKEKASALLPYYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L867</accession>
    <name>A0A367L867_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase M3A/M3B catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_4389</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L867"/>
    <dbReference type="STRING" id="1330021.A0A367L867"/>
    <dbReference type="OrthoDB" id="534666at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06455">
        <property type="entry name" value="M3A_TOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.40">
        <property type="entry name" value="Endopeptidase. Chain P, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024080">
        <property type="entry name" value="Neurolysin/TOP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF84">
        <property type="entry name" value="SACCHAROLYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016925300" description="Peptidase M3A/M3B catalytic domain-containing protein" evidence="9">
        <location>
            <begin position="19"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="10">
        <location>
            <begin position="256"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="505"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="511"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI10604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="768" mass="86275" checksum="BA7F90A20D6CBA65" modified="2018-11-07" version="1">MLALHLLLVLVTAWPVLSRTTPQLNFKRPPQKPPMMPVTGDSIRREAWHIMNSTLSIYDSIVQNVKPENATFANVVEPVLSGMSENDPSVLIFLRYVSPDADVRLASSQVTQLLSTFNNKMMSNKDYYRLLKAVMESASTAGLDEEQRRILGIHYHKMFLLNGPEDAAATSTLASVQASSAGTIHDIQTIRAEMHNLSLTAERNIMEGNGGVWFSPEQLKGVPAEKMAMHNLENGTGEHEGKLKVTFEPDLGQLVLRHASNEATRRDYLVARANKDKVNVPILRDLVLLRDLLARRLGADNHASIRLHNTMAKTPTAVNDFLDDLRKRIEALGSPRLESLLELKKMDYKKQNVNFDGGLYDWDREYYAHYDAEKNGTTENGDEAAKAKEKDVSQYFPFDSTLERALKMMGKLFGLVFVELDAKDRARLSETKKGEDLIWHEDVRMYAVWDDEEAGNGFSGYFYLDAFRRENKFDHAAELNLVSTFVRKDGSRKYPAAAVMCNVGEKPKAASSSSSSSSSSSSSSKEKEEGDEVLLTHRSVVVLLHELGHAIHDLTTRTKYLSRNMAMDFIEAPSQMLENWAWQPSVLKSLSRHWKTDKPLPDEAIKEIVDSRGGLAMASVASQVIVSTFDMRIHSPPSREAAEKLDPTGLWNDLQRQVLGSKVPDGFDRNWNKAYAGIDHFYGGYDANLYSYLWTVVYADDMFSSAFAEDPMNGGEGRRFRRTVLEPGGSVDSMKLLEKFLGRKPSAEAFYKRHGLEPKKDETKKDGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L888</accession>
    <name>A0A367L888_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_4463</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L888"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI10637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="74" mass="8442" checksum="8F93C5EC52C50DB1" modified="2018-11-07" version="1" fragment="single">DSINTAFCKDMQYERLLFDFYVETGGSRFAGGLANFTNAPLKRRIELEDEYSLYAFSDCQLLDIIRSSCGDRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8G4</accession>
    <name>A0A367L8G4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sin3 associated polypeptide p18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_5302</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8G4"/>
    <dbReference type="STRING" id="1330021.A0A367L8G4"/>
    <dbReference type="OrthoDB" id="440566at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.550">
        <property type="entry name" value="ASAP complex, SAP18 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010516">
        <property type="entry name" value="SAP18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042534">
        <property type="entry name" value="SAP18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13082:SF0">
        <property type="entry name" value="HISTONE DEACETYLASE COMPLEX SUBUNIT SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13082">
        <property type="entry name" value="SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06487">
        <property type="entry name" value="SAP18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="176"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI10720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="23491" checksum="551B0132602CD430" modified="2018-11-07" version="1">MSPQSGDSHRRPPAPFLVHLMYRSGAFFRPEDFSSKPLPPHVSLYTWPSCTLSELAMELAALKPSALPHPAVGTRLVFQLVYPDLRSTAPFGDALPRYAVKDLGSIVIGHSGPGAETSELGATGGTSRNDHDIGRTLNHARFVVGDFVSCAILPPLSDGSVAPASNARSYGIRENGLGGGRGIRAGRREGGPGGTGGGVPKGEWRRGETLPDMSPRRGASRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8I3</accession>
    <name>A0A367L8I3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LITAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8I3"/>
    <dbReference type="STRING" id="1330021.A0A367L8I3"/>
    <dbReference type="OrthoDB" id="5599753at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006629">
        <property type="entry name" value="LITAF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10601">
        <property type="entry name" value="zf-LITAF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51837">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LITAF" evidence="1">
        <location>
            <begin position="55"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="181" mass="19436" checksum="0081DA74CC34334B" modified="2018-11-07" version="1">MPDTALLATTSQIFFSASMATTAQDAPAGPAPAKEMPAGLVQTEVQAMPVINPLPKPQTVTPLHLVARGTQWIDCPFCQRRAQVTDRGVGTGMQTVTGVLCCLICPCFACIPCLAHWFENIEYVCSNCHRVVALRPHDGPIQTFGPVQPSGQQQIYGQQQGPTLVPSQYYEAPPATTVKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L930</accession>
    <name>A0A367L930_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L930"/>
    <dbReference type="STRING" id="1330021.A0A367L930"/>
    <dbReference type="OrthoDB" id="1911848at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1020">
        <property type="entry name" value="Prion-inhibition and propagation, HeLo domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029498">
        <property type="entry name" value="HeLo_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038305">
        <property type="entry name" value="HeLo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542">
        <property type="entry name" value="HELO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14479">
        <property type="entry name" value="HeLo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="226"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="515" mass="57760" checksum="A330D99EFE523924" modified="2018-11-07" version="1">MALEFQIGAAGLGLGAFSAALDLLSSCSSIYNLWKSAEGLDVQLETLRAFLMLQQALLEQWQRDWLDMSVSDPRAVNRRLLLKQHQPTVERTLGTVQKLLRELEPLRKTACGTQKKSLSATERLQWLAREAASSEKVLADIDTLLSSLYRLFPVWTPNPDASAAIVALEHIPNVVSTPGATLNKAINLRQLRRGLDRDLEQRAAGFLQSMPKTDLDLASSQVDITEHDSTTAGLRSFGLLDKASKVMVEWKKYDSSWRGQKGIRMRGRIRNIAQFLHADSKPDELLTPRCVGVFDDVEHSRYGFVFSLPSDAGATIMSLKQLLDHRTPETLPSLEDRYRVAYHVGLSLAMLHTAGWLHKSIRSHNVLFCVRNGRPVWKRPYLAGFDFSRPDAVDESSEKPDQSARFNLYRHPLAQGCPGEDYRKGFDVYSFGVVLVELGLWRSAWKLWVDGMSATAYKDCLVAKSRDWLAHSMGNLFQDVALKCLTGELETRKGPMQQVFCVEAVEVLGRLMADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L985</accession>
    <name>A0A367L985_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Tryptophan--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_5434</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L985"/>
    <dbReference type="STRING" id="1330021.A0A367L985"/>
    <dbReference type="OrthoDB" id="15808at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070183">
        <property type="term" value="P:mitochondrial tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000082">
        <property type="entry name" value="MSW1p Mitochondrial tryptophanyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000002">
        <property type="entry name" value="Tryptophan--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050203">
        <property type="entry name" value="Trp-tRNA_synthetase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43766:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI10985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="350" mass="38867" checksum="3F0C2827053C92F3" modified="2018-11-07" version="1">MHKKALMRPRVIFSGIQPTGVPHIGNYIGALRQWSHLQDVEASTTKLLFSIVDLHALTTPQKPGKLKQSRRETLAALLATGLDPERCIIFNQSSVPAHSELMWILSCTASVGYLSRMTQWKQKLNVPPTSELVDRSLGSLLKLGLFAYPVLQAADVLVHRATHVPVGHDQQQHIEFARECATNFNHTYGPHLVHPETMTPSRHRIMSLTDPTSKMSKSHKSERSRILVTDAASQIHAKIASALTDSASGITYDLTQRPGISNLLEIYAAFDPQRRTPQQLAEAYTTAQPRQLKSMVADAVVEGLRGIRDKFLDLQQDDNGYLEQVEAEGAEKARQSAQETMDLVRNAIGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LA13</accession>
    <name>A0A367LA13_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase C14 caspase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_7501</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LA13"/>
    <dbReference type="STRING" id="1330021.A0A367LA13"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="6">
        <location>
            <begin position="135"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="27"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI11261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="429" mass="47034" checksum="5AF840CDB2AFD824" modified="2018-11-07" version="1">MSAFPYGGSGGYGHPQQHFSGNYFQQAPLPQQSFNGYQQGHGSPQPGYGYHPAQFQYGYQNSPSPQQYVDPGSYGHMVPQPSYGSSRPSPGMHPAHHSPLPQARLGPEAPPSEPQQFGQGAPQGYAFRYSNCTGRRKALLIGINYFGQRGQLRGCINDVRNMTAYLAEHFGYKREDMVILTDDQQNPMSQPTKQNILRAMHWLVKDARPNDALFFHYSGHGGQTKDVEGDEPDGYDEVIYPVDFRQTGHITDDEMHRIMVQPLQAGVRLTAIFDSCHSGTALDLPYIYSTQGILKTPNLAKEASQGLLGVISSYSQGDLGGVANGIASFFKKATSGDESRSRALATKTSPADVIMLSGSKDDQTSADVTIASQPTGAMSWAFVNALKKNPQQSYVQLLNSIRDELATKYTQKPQLSCSHPLNTNLLFVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LA94</accession>
    <name>A0A367LA94_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LA94"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI11333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="117" mass="12275" checksum="2F1070AEF7607F33" modified="2018-11-07" version="1">MSDALGQPDALTPLAKQALEHSGALLKSAAAAAAAKIANSVVFNCIVKSFVGQSGVWIEGKVLAHQRRAKPAATRAFYAYRPSAHTVPDIGQVPMTPLQINSSPQEPCLHDADCAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAA5</accession>
    <name>A0A367LAA5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VanZ-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_7605</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAA5"/>
    <dbReference type="OrthoDB" id="63581at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006976">
        <property type="entry name" value="VanZ-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037970">
        <property type="entry name" value="vanZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28008">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28008:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04892">
        <property type="entry name" value="VanZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016817652" description="VanZ-like domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="VanZ-like" evidence="4">
        <location>
            <begin position="34"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI11346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="202" mass="22642" checksum="55DAB45EBFCE6610" modified="2018-11-07" version="1">MRIRLPFAGGFLLLLLAAAYAGLSTLQLGHFVNDKVLHTITFFLLTVVFYWIVDTNRRRTLNMTLIVCTLILGVGSEFVQSFLPNDRDFDLYDIVANVVGSLAGLGLCSWYHRRMLERRRKRKQYTAVPDEEGVELSPDHEAGVTDGPSLPRTLEEEVDNWNENAADDWDGDITTEASPPPVIAKAKEPDAHDPGEAKKRTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAF9</accession>
    <name>A0A367LAF9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7548</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0235 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAF9"/>
    <dbReference type="STRING" id="1330021.A0A367LAF9"/>
    <dbReference type="OrthoDB" id="244097at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1200.10">
        <property type="entry name" value="YggU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003746">
        <property type="entry name" value="DUF167"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036591">
        <property type="entry name" value="YggU-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00251">
        <property type="entry name" value="DUF167 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02594">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01152">
        <property type="entry name" value="DUF167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69786">
        <property type="entry name" value="YggU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="127" mass="14044" checksum="4FD85A67C673B603" modified="2018-11-07" version="1">MATASSAVRFIGPLTVKPPLTGVIQIHLHVNPGSSNIMRGIVKRVTADRIVLNLAAHARDGAANDAAIAYLALVSRIQRPRFRLRCGHRCRDKTFEVAGIRLEEGPKLAQHILDRFMRASKKKKKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAL1</accession>
    <name>A0A367LAL1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_7212</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LAL1"/>
    <dbReference type="OrthoDB" id="2123378at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000311">
        <property type="entry name" value="GTP binding protein (Bud4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012966">
        <property type="entry name" value="AHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052007">
        <property type="entry name" value="Bud4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36100">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36100:SF1">
        <property type="entry name" value="BUD SITE SELECTION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08174">
        <property type="entry name" value="Anillin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="1211"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="772"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="871"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1360"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="72"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="136"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="214"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="294"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="382"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="484"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="527"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="600"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="647"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="664"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="701"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="781"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="889"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="938"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1360"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1370"/>
            <end position="1379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI11455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1379" mass="152268" checksum="4B3A8FF67899C473" modified="2018-11-07" version="1">MASEPVHPLRIAKHTTPNSSPTKMPSGLPRPLSEISPTEKRRNSPSWRQYTPTKPHADLLAWRGGGKAATPGNDSSPFQSSPLEATSSPRLFWQNRNAENMLHAGGPASSPTRRSSIERLQRASRVRNSNILALEQKQEYDPTRLPRIERPLAKVQGNILASPSSSAGVRSSDSEQRALDSKSSLTTMSPTKSSPILSPSPNIVPRAPSKDQASPTKSSLSPSKLNKSTLEPEPVTWSGHSSLDERELPDGRFLHRHPKSVTFDAAPPQINEYEMATPDLSSIGTNSREGSFESAEDEDEEDEDVLYHPTHTAVQDDSFDESLEDTDKTPVVGPDDWRGESPLVQPAGPSEDVDGRRPNESVSSNGDQRPLPPLPSLGHTRSQSASSIPASPALSATAERMLGGGSNHRSLPVPPPASAKSDIQSFGHGKMTLEERLKLMMLSDDTSAKSAAEQQRERRLRRGAVSRDRGDTPQSEPESAVDGEESRTDDARDSPLLDDYQLPPRISRESIMRRVNGNKALDDDDPFTSPDAAAAAATTVGHRNSTDGSRLTLGSLDPDVPIPSTEDPSLHEAYGVDCAEDDAVRSRASTEEDEATGDDVESHYSEDEPPREESHSQEIDSGVRTPRPASPALHLKLGKDMPDLGPAVLSAAADARAQAATPTETKDERSTSTEDRVSIQRPRTPEARTSKPEYDGSGWGDPEEEFEEESGTPDSVIRHPQVDDESELLESPVIPERIATIKSASGSKLKTRISNTPSDLAAMREARRQVSQEVPQVPPIPERHRKPDLASKGLDEIPDEQAERRASFKNRSLTLDIDMGLSLDQDFERVIEAQKVCPTSPVFPRSRSRRCGLKRVDANVTIRPQRGYLMRQNTKLVSASDKDGDATWKSRSANNSPVKQDRPQSWIIEPWKGSESRSKSPRKRPGTSAGPAPPMPGQESNRGAQRQVSTSDTQSEAATIDTVERGRLFVKVMGVKDLDLPLPKNERTWFSLTLDNGVHCVTTAWLELARNAPIGQEFELVVPNDLEFQLTLNVKLEKPVHSELPAVAGKAAKPKTSTFSRVFASPRKRRELEMRQKAEEERFAAQQKEALARRNRAPSGFELLSPLAAEDGSFGRAYVCLKEHEGRCFGRPYMADVVLFNEWATEEESFASSVKSKRGTSAVVRRAPYKIGKLELQLLFVPRPKNSSDDDMPKSMNSCVRELRAAEERLARSWEGHLSQQGGDCPYWRRRYFKLVGSKLTAYHESTRQPRATINLCNAKRLIDDRRSLTERDTAGKHGKRRKSAFAEEEEGYMFVEEGFRIRFNNGEVIDFYADTASDKEAWMRVLSEVVGRGGDGGDESGGVRSRAKWCELVLRREEQLRRRSEGRRSHSRAKGSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAQ8</accession>
    <name>A0A367LAQ8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nitrogen regulatory protein areA GATA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_7236</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAQ8"/>
    <dbReference type="STRING" id="1330021.A0A367LAQ8"/>
    <dbReference type="OrthoDB" id="5563539at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007039">
        <property type="term" value="P:protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052292">
        <property type="entry name" value="Glucose_repression_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28051">
        <property type="entry name" value="PROTEIN MTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28051:SF1">
        <property type="entry name" value="PROTEIN MTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitrogen regulatory protein areA GATA-like" evidence="2">
        <location>
            <begin position="176"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="448"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI11494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="572" mass="63226" checksum="BF1D57FD2B421D25" modified="2018-11-07" version="1">MAAVLSSADDCGYFGPLRRSRSQSNFAVDSSPTHHYSPSPSPSFYVNFYPESDLSSSPPTVQAESTDDGSFSSTPTSNLSVASDSEELPSFDNCPDDDPFDLPLLSQEKFFIQPEVRDAEKLELSPKTAGSCTPPAAPDTPVRIEHAQDDCAATNKPSRQVDYLSHDWTEEDIWSSWRYVISKRGSQEFPNCQRLENACWRTWSKVKNGLKTISPEELNWLKDCDVTWLYGPLQTGSSRLQASRTESCSRSLSNSESLVNLAKKPILKKRSMSEMMLQRSLTSSSLLKQATAAVQAQETSAAVLRPTMARAMTDCYLALPLCSRQSSQSQETNMSLAASTDSSGISSPCTERKHIHFNEQVEQCIAVEVKCDDDDDDDDRGAGPYDSDSDDGVVMKRIKPKRRAPSMRRRASKTTQTEGKTIAMLPSTKLKYREDASESRMTHAAAGSPLLSPSSPLLSPSSSQETLRPSRQASVFYFDGDDYDDDSIHVEAATTSDERATQDRLPQRSPSSSASLYDEPPVVGMRRTWSGMLMPCEDDEPRPGDGILGRVLDTVNTARDIAHVIWNVGWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LB63</accession>
    <name>A0A367LB63_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L249_7211</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LB63"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17996">
        <property type="entry name" value="DEXHc_SMARCA2_SMARCA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000008">
        <property type="entry name" value="Chromatin structure-remodeling complex subunit snf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000843">
        <property type="entry name" value="Chromatin structure-remodeling complex subunit snf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000072">
        <property type="entry name" value="Putative chromatin structure-remodeling complex subunit snf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014978">
        <property type="entry name" value="Gln-Leu-Gln_QLQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014012">
        <property type="entry name" value="HSA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029295">
        <property type="entry name" value="SnAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07529">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08880">
        <property type="entry name" value="QLQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14619">
        <property type="entry name" value="SnAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00951">
        <property type="entry name" value="QLQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01314">
        <property type="entry name" value="SnAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51204">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51666">
        <property type="entry name" value="QLQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="QLQ" evidence="16">
        <location>
            <begin position="153"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="HSA" evidence="15">
        <location>
            <begin position="395"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="575"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="886"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="12">
        <location>
            <begin position="1303"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="64"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="198"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1159"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1401"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="64"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1196"/>
            <end position="1206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCI11656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1841" mass="205770" checksum="00ED4F1B1A6FB458" modified="2018-11-07" version="1">MASVQVPPAVQHPGAPMPAGATKQQAEEVFRKLKQMKEQGVPPSDPEYIKASHFLMNFQQQHNMRRTQQQYMQQHQQHQHQPPPPPPPPLSHQQPKPHMLGAANGAVNGGRPQHGGASQSAQPNPNTTPPAASGPGPALGPGSGSGSGSGSIQFSQQQLALLRQQIHAFKLLGKNAGVSAQLQQAIFNQRQRRQAAAAAATAVAESPQSTSAKFPQDAAKTTPTGPDMAAPQESDSSSAIPKPHVYKSVRLPYGSSLVRSSIKYLDHASRKNRWFIPGIFPTGIDFDHLRYEREVILFNRMAQRYSDLKNLPANLAHWDTTKETMEADDSLKLKAIIEMKALGLYAKQRALRDKIGRQMMHYDNLAMTTNRSHYRRMKKQNVREARITEKLEKQQRDARENREKKKHVDFLRAICHHRAEIHDAANAQRTKMHKLSRLMYAQHFNIEKEEQKRVERTAKQRLQALKANDEEAYLKLLDQAKDTRITHLLKQTDGFLHQLASSVKAQQRRAAETYGDDMNAFVQEEAEDDGSTGGSKKIDYYAVAHRVREEVTEQASILVGGTLKEYQLKGLQWMLSLYNNNLNGILADEMGLGKTIQTISLITYLIERKLQSGPYLVIVPLSTLTNWNLEFEKWAPSVSRIVYKGPPNTRKLQQEKIRQGRFQVLLTTYEYIIKDRPILSKIKWFHMIIDEGHRMKNTNSKLSATIQQYYVTRFRLILTGTPLQNNLAELWAMLNFVLPNIFKSVKTFDEWFNTPFANTGGQDKMELTEEEQILVIRRLHKVLRPFLLRRLKKDVEKDLPDKTEKVIKCKFSALQSRLYKQMVTHNKLVVSDGKGGKTSARGLSNMIMQLRKLCNHPFVFDEVENVMNPMSISNDLLWRTAGKFELLDRILPKYQATGHRVLMFFQMTAIMDIMEDYLRYRKFEYLRLDGTTKADERSDLLREFNAPDSKYFMFLLSTRAGGLGLNLQTADTVIIYDSDWNPHQDLQAQDRAHRIGQKNEVRILRLISTNSVEEKILERARFKLDMDGKVIQAGRFDNKSSETDRDAMLRTLLETADMAESGEQDDMEDEELNMMLARNDDELVVFQKMDEQRQKDATYGTAAGARAKPRLMGEDELPDIYLNEGNPVEEENEEVALGRGARERTKVRYDDGLTEEQWLMAVDDDEDSPEAAAARKMARKDKRENNRLKKMALMNSMDNSPSGSRGSTEEVETPKKRGRKPGSKNEKRKAEDGDEEPPAKKRRGPQGRPSRVGSGAGSGGDSRVSGQLRETLQKSLRSLYDALMALEVDDIEPPADDDESDAGKRLIIGPFVKLPPKRDYADYYVIIQNPICMNQIQTRIRKEEYGCLGDLRKDIELMIRNCQTYNEDGSILYQDARTMEEFFNSKFAEELEAHPELAEVESGSVAPSGSGGTPQPGGTRIRIVSSGGANGGRSGLSDEEMRKTVILCFIHGFKGDDKTFGQDLGFTEDLRAEVARRLTRVHVRVLVYPTYETRGDLGECVSRFRSWLEDKVIDIEVEAGTTSPTVEPSVRTVLVGHSMGGIVAAETVIGLASEKPIYSEDGVEKKEDPSTAAAFNGLMFPYVQAVLALDTPFLGISPGVVAHGAEGHYQNAAAAISQLNGLSNMIWGSNAGGGGGGGGGAAGEKSATALTTTTASANDNSSWARWGKVAMYAGAAGAMAAGGAAAWANREHLTTGWTWASSHLEFVGCLARPEQLKKRVSCMVQLADELSIGFANVYTRLGKAASSSRTVSVTGVVAGTVLGRERTFCNLPKTMTAGQWVEAVNDKAPNEPRAHMNMFEPDANPGYEALTMDAAALIEKWFRNEWYEADEKSPVDDDAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LB81</accession>
    <name>A0A367LB81_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphatidate phosphatase APP1 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_7356</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LB81"/>
    <dbReference type="STRING" id="1330021.A0A367LB81"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019236">
        <property type="entry name" value="APP1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052935">
        <property type="entry name" value="Mg2+_PAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208:SF1">
        <property type="entry name" value="FILAMENT ORGANIZATION PROTEIN APP1-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06650)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09949">
        <property type="entry name" value="APP1_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidate phosphatase APP1 catalytic" evidence="2">
        <location>
            <begin position="209"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI11676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="422" mass="46902" checksum="32D25AE04AD44D63" modified="2018-11-07" version="1">MDPVNSFHSSLASTMQRRTRQKNNFEEIESSLPSLESSPEPSLSRFCRPGGFLGKLTRFLPGGRAVKKSNIVWLLDNTAFRHATHGHWCAEFIAAVFEREDKARLVDVVSGVAHAVGLADDAKERKTVEERVLPFLWDIRPATTITALHQGRTRLRIGPSNANGLCSNVLTIPGSAEGSLVRTSAKSSKAGGDGAIPHMETYYAGPEGWGIISDIDDTIKVTLTSDPVGILRESFVNTPSPIPGMPELYAEMKTLLPEDTAWFYLSASPYNLYPFLKKFRKDHYPSGTLILRDSSWKTMAGLLSALTLDTEEYKVDRMTKINSWLPKKKMIVVGDSTQSDPEAYGEIYRTFPGWIKLILIRKATDVAAVGIEEKNEPERFEAAFEDIPREAWHVFEDPSECVEIIQTAISRVESDSEHLAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBT0</accession>
    <name>A0A367LBT0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBT0"/>
    <dbReference type="STRING" id="1330021.A0A367LBT0"/>
    <dbReference type="OrthoDB" id="10261782at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038921">
        <property type="entry name" value="YOR389W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35204:SF1">
        <property type="entry name" value="ENTEROTOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35204">
        <property type="entry name" value="YALI0A21131P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017016729" evidence="1">
        <location>
            <begin position="22"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="552" mass="61534" checksum="F3626BA17ECFABDA" modified="2018-11-07" version="1">MAPNRLRHLLILAITSLTAEAIAPSIESARANSHRIFNAVNHAGRQWGSALNHNGFSFFSAVVPAGTLLYRGSPDDEFPPEGVEWLAFELEHAQQFATPKDEFHADDGRQKPLLRRRRRRGYIQTYQATRDIPLLYADGMSAAKTSFGTLDSQDLILRDNKTADAASMAEQGRAADICRLIQPWGYAGLVRMEAGFEVVYCDFANGIRLLSAVRMHLAEDKVGDDALRTPLWVRAVTERYDGLGVDRLSIDFSSMLSAFFFPINVSGTDPSRPDLVRLAATPLHQLRDIKTRLEHVASQPRRFTVDWQAVTDMVVRRFANRLAHMAADGDGISDMAFIDELESAVLLYIDGPSNATSIAAPTGDETTKLCTQHLLLSSTLSQPQWTESDRLIHAAIEAVLHDTCTTLLSVFTSLVEASSKDITGAAQPNRHLSTAVAAGRRDVKHLVQRLSWSEWRKVRRCPVGEVMFSVMWPLGNQEDYWQPGCRRLEDLGFERQGYWGTEDGPLRRVELANQAPDRQALIALDHGRRLVGRRFRRSDPKLVDAPAQVEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBT8</accession>
    <name>A0A367LBT8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_4189</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000009">
        <property type="protein sequence ID" value="RCI11890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBT8"/>
    <dbReference type="STRING" id="1330021.A0A367LBT8"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI11890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="111" mass="12222" checksum="F66CE7854A0853E8" modified="2018-11-07" version="1" fragment="single">IAPSAAPPDRAPGDTVGVLIATFRDKEDRIGFLFRSLEGKARKTLETRLLTKTKDNSLSYEDFCGYVKDLAIKRLNAELVLPNNLPALAKYSLSILLPKTPLLNKQIDPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBV0</accession>
    <name>A0A367LBV0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MICOS complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_4206</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000009">
        <property type="protein sequence ID" value="RCI11900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBV0"/>
    <dbReference type="STRING" id="1330021.A0A367LBV0"/>
    <dbReference type="OrthoDB" id="2399148at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044284">
        <property type="term" value="C:mitochondrial crista junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019166">
        <property type="entry name" value="MIC26/MIC27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033181">
        <property type="entry name" value="Mic26_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28268">
        <property type="entry name" value="MICOS SUBUNIT MIC26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28268:SF1">
        <property type="entry name" value="MICOS SUBUNIT MIC26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09769">
        <property type="entry name" value="ApoO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017050277" description="MICOS complex subunit" evidence="2">
        <location>
            <begin position="33"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI11900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="255" mass="27841" checksum="67D50A1668957E16" modified="2018-11-07" version="1">MAARVLFQRRSTAPLAALALASLALTPATARAESPAEVSTDQRKPIYDDVYLSTTSSSLLPATKSLPASQQQKLVEDGESRPARPTPTDRLAVQIGRARVFLHRYAVAVEDRINATMDSAFHLEQSFTDTVASLAPPRGSGERLMPGAIYVLVAAMAGTIMTRNRNFILRATVPLALGVGAGWAVLPLTMRNVSDLSWRYEQRFPAVADAHVKLREGIQDGIRFAKVRSEQGVRYVDNRVTDAREAVEGWVKQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LC48</accession>
    <name>A0A367LC48_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 8</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MED8</name>
        <name evidence="11" type="ORF">L249_4584</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000008">
        <property type="protein sequence ID" value="RCI11981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LC48"/>
    <dbReference type="STRING" id="1330021.A0A367LC48"/>
    <dbReference type="OrthoDB" id="5329317at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019364">
        <property type="entry name" value="Mediatior_Med8_fun/met"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13074">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13074:SF9">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10232">
        <property type="entry name" value="Med8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="169"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI11981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="285" mass="31264" checksum="F1B044F59A1ACAC8" modified="2018-11-07" version="1">MATLSLDDDELKTVEQMLSRLAQLSSSIQSLKMDILKSSPLPPPSSLQATAQILQRNLQTVLDSLSENNDLFGRMAIHPATNYPGRTQEGVLTQLLRKKLEPDVEELVAVGREAAALATVEGIVALEGIWDELRQWTHERIASYVRDEAGKVFTVDEREGGLDVVRTGLRRALEEESDDDDDDDDDDDDDDDDGGGDDDGKEEGGEATKNGNENGNRHGRGAGKSRRLPRGPELETLLWFAEHGDFELPVNVEYERKVGVRKGIEGVNIPPETVVDAARPPAMVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCQ4</accession>
    <name>A0A367LCQ4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCQ4"/>
    <dbReference type="STRING" id="1330021.A0A367LCQ4"/>
    <dbReference type="OrthoDB" id="5234071at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="499" mass="52362" checksum="A5955F273C0CBA41" modified="2018-11-07" version="1">MVSFFGIKLKESRKSLHASPQPSPGPSILTSRRKPQTQPRPQPVPPKTENKVPTQNQQPAFNFSRPQNQAARSVTSHSRKAAPESPSWRAVFGDAGASSSTADLPLPVMGNLRRNVSDLNLYASRAAHPSAASLPMPSLSGLRPGTPTRPSSRKADWVNPLDVHFCRNQSPSPLHHHAKQLDKNGDFGRDACPSPPHSDGNADRPFVPHHPSVGRVSLDSSGCNGQGALLRNVEAPSATLLPSPAPSSPVISDGGGQTTQATLQKKGFVGNFSDFDFGDCVLKSSVCAVGGGTDRPDRACSDAAPEAAVHGFSARVDSMAHCRRARPPRPLDARSTAESPSRSTDHTRRLVERPPSSPFSLQPMEGDFPVSGGLPRGRRPGQPSPPLTSGAGVEASKGETPGGPWPTFNRGDVRRSAVPPPLSMSSGRSPSGSGSSSSVGSASTQRTDSPILSFTNSSEDLVKSFEMALEESLGGCLFTSSAGVIGAGLVEPARRTGHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LD12</accession>
    <name>A0A367LD12_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_1319</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LD12"/>
    <dbReference type="STRING" id="1330021.A0A367LD12"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044843">
        <property type="term" value="P:cell cycle G1/S phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20537">
        <property type="entry name" value="CYCLIN_CCNO-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20559">
        <property type="entry name" value="CYCLIN_ScCLN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000010">
        <property type="entry name" value="G1/S-specific cyclin Cln1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3 5" id="KW-0195">Cyclin</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="98"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI12306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="385" mass="43204" checksum="AA17588A58E362A6" modified="2018-11-07" version="1">MDYDHPDETFFESEEARPSCMDARTAAKMVARHRQQLIADDLSRTTAGEYLEDILKHTQTMEASLFCCVDDVDETLPDASLIDMQREVQWYMRPYLIDFLIEAHAAFVLLPETLFLTVNLLDRYCSRRVVYRHHYQLVGCAALLIAAKYGDKKDRVPQISELSNMCCALYDGGMFSQMEMHLLDTLEWSIGHPTVDFYIHLMVTYEGHGAVVDCLASYLSEMALYHRDFVSVRPSVLARVCLTVASFVLGRSEGMEFGPDEEKTVAESLFRHLDSPSPTLARKYSSTGTYRVSQRLAEFLAARAAEAASSMAQRHVDPPTPPPMEKRGGDIYSTPHKGQVVATVAAMDGYLTPPITPDGGCFVAPRCPMTPTPEFQQHVGLLPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LD65</accession>
    <name>A0A367LD65_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">D-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="18">1.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">L249_0216</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-5/BimC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.4" evidence="18"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LD65"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000073">
        <property type="term" value="P:initial mitotic spindle pole body separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01364">
        <property type="entry name" value="KISc_BimC_Eg5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000014">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000051">
        <property type="entry name" value="Kinesin-like protein bimC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047241">
        <property type="entry name" value="KIF11-like_kin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005373">
        <property type="entry name" value="PHAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF116">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE (CYTOCHROME) (AFU_ORTHOLOGUE AFUA_7G02560)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03676">
        <property type="entry name" value="PHAF1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 20" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="22" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14 20" id="KW-0505">Motor protein</keyword>
    <keyword evidence="8 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="24">
        <location>
            <begin position="177"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="Kinesin motor" evidence="23">
        <location>
            <begin position="1239"/>
            <end position="1581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="20"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="907"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1159"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1212"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="2182"/>
            <end position="2276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="907"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="946"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="1169"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="1220"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="2223"/>
            <end position="2239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="21">
        <location>
            <begin position="2254"/>
            <end position="2263"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="1325"/>
            <end position="1332"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00034704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00038897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="RCI12357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="2315" mass="251602" checksum="C8A90BBF8B799550" modified="2018-11-07" version="1">MASLKVRLAKSALPLRPRFAPAATRRYATGSEPPDRPAKPPMVERRRAEPARPEPSFAGQVQGSIQARLRREREQREQYERWRELKDPSRNWMVTFFFVSGLGIAYYLGTFWPRERDPSSTLPLSKARGPRHNTKLENMQAAWYDFIEIVGKDNVSTLDDDVERHRTSSWSSHQPQPDEKPFCVVYPASTDEVSRLLKVCHKRRIPVVGYSGGTSLEGHYVQTRKGISIDFGRMDKVLALHKEDMDVVVQPAVGWESLNDLLADDGLFFPPDPGRGAMIGGMVGTGCSGTNAFRYGTIREWVLSLTVVLADGTVIKTRQRPRKSSAGYDLTKLFIGSEGTLGLVTEAVLKVTVKPQATSVAVCSFPSVHQAAACAASVVANGVPVAAVEILDDNQMRFTNAAGTTSRTWAEAPTLFFKFSGTAMGVKEQAAQVQALARKAGALTFEAARNQDEQEELWSARRSALWSTMAAGRESDKVWTGDVAVPMTYLPEIIEKTKEDLKSSGMTAGIVGHVGDGNFHSRILPCRLPLFSKTDAASALVCLLYSDAQRSKAEKVVHRMVKRAIEMEGTVTGEHGVGLVKRDYLPHELGETTVDAMRQIKLALDPLCLLNCDKVVRVEKPKSGLGASLHDVLTRLKAEPQRFPKLEVVYSPEQPVTEMVCVVLPQNGVRLRFDGPEQRLRLIEVTDFTKNHITFKDRDLLKPAAAAAAAVAAAANGGGSRSPPLGTQAVGPTFRHIYHRVLGPTYAGEFIPPGPGGGDGIYVLSYPGVAFNFALAEAAYSPDKDVVTLLAAASSQAATSMAVFSGDSWAEARPTLWTAPLPSVRLPSSVVGGGARSRDSYPDEVSLVRLRGSGGSIDMVRKWNGSGPVFRLQLGETTPQDLVMALGPPSAIYRKNDQKMVIHTMRAAADGARGGRSKAANAANADAGRPDDLTDTDQSSMNTGSDESDGEATGDGDDGEHDQGGGGSSGECFYNYFYLGFDVLLSRPTAGRSSSTGSNGIKNQHPDRLVATKLVLHGNIPGCYEFNRHRRCRWELRPDGPDSDDTAETTTAAAAAPLADSETEFKVIEERLARRCDGGGGAATRQRGMVLNRGWGDSPGSSCEFLGGWEESGGGRRAEVAGGDSTTTLYGFPGLVFEVLRNGYVNTVTCDRLAALASRRTTRPDREAAAGGRAAAPSSMRSAATVRGRTWGAATAARTAAAVRSSAAASGIGRAPSAAEARRKERESSTDAVGGEGSNINVVVRCRGRSEREVREGSPVVLRTDGVKGKVVELSTGAHALSNKTYSFDRVFSAAADQNMVFDDVVKPILDDMLAGYNCTIFAYGQTGTGKTYTMSGDMEETTLGMVSEEAGIIPRALQHLFNRLELGAGESCVKCSFIELYNEELRDLLAAEETRLKMFDDAARKTTVIQGMEERHIADAAQGLRVLRQGSVRRQVAATKCNDLSSRGHTVFTVTAYVKRGSDANGNNGGGGDDDVVAAGKLNLVDLAGSENIQRSGAEKLRAAEAGLINKSLLTLGRVINALVDGGAHIPYRESKLTRLLQDSLGGRTKTCIIATVSPARSNLEETMSTLDYAFRAKNIRNRPQLNAPLNKKMLLRDFAVEIERLKADLIATRQRNGVYLAVDAYDDMTAQSESRRIVVDEQAAKIETLESNLRNKVQDLFSMTSAFMGLRRDHDATRLQLDDARGLLERADIVLAATRASLAKETQRRRAHAETEERLAAVGGELVDTLRRTVDDVDGLHAKNRRRSDLQALNRVAWADGQARVADVTLAVERRLAEFRDAHLRHVTAIGDRLDGFVEAQLSGLDDARALLDGHVVALEDARRGERDQRLRAGDEADALLDAVADVRDSLKTHLAESLRAVSRAAEAISADVLHDMTAFHASVSSASFAWVNACFAKSRMNQLHDSYSSLGKDFKSIFDDLVRHMTAQRSEAESLRRQLQATAAAAALQNASAAARIQEALDEERRQAADDRQKLTAQVATLVAAQAESHEARLTERASLLHRAVTDCGASLEAAAAQHGRGMDAWDEREGRLLDEVRRSRDQLKAKLKDDWATAGEQSATMQAVARSVHAQTARVVDKQVDGLDEQMEMLDRLVARARADKVARHDEEAQTERARAQTVDQSLGGLATQLTTVTDRVRELGDEVDAAALADELGPLDDHVRGPLERLRLGFSTSALREYQPTGQTPRKVVYTFPTTLPRTELVEEEEEEEEDKGKGEGEDVVVEADEQQQDDDNDKNDNDEAVHRRRQQQPPPPPPRAPPAAHSPRGERQRRRALSLALDHGRYHHGVVCCRLGPRRRPVAQEADALVCSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LD80</accession>
    <name>A0A367LD80_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LD80"/>
    <dbReference type="OrthoDB" id="5103851at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017074298" evidence="1">
        <location>
            <begin position="22"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="183" mass="18454" checksum="CADC64E4333FBC49" modified="2018-11-07" version="1">MPAPVANALLMAAGLAAVAGAVEPYNFAANNATTETLAPQELGSMTADGSVLYTVNMCTVVRSINCQLTTSTSTQGSGAAPSTGLKVGTSIQAYSAEGSVETPVSFVPDATTTQTEVGQTTMTRGNSSMPTTRKALTATESVQYWPSTSTYSAMPTSTGASNTVSVMRGVAVGAGAMAVAFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDG2</accession>
    <name>A0A367LDG2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GRIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_0373</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDG2"/>
    <dbReference type="STRING" id="1330021.A0A367LDG2"/>
    <dbReference type="OrthoDB" id="425925at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019459">
        <property type="entry name" value="GRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000237">
        <property type="entry name" value="GRIP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18921">
        <property type="entry name" value="MYOSIN HEAVY CHAIN - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18921:SF2">
        <property type="entry name" value="THYROID RECEPTOR-INTERACTING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10375">
        <property type="entry name" value="GRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50913">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRIP" evidence="5">
        <location>
            <begin position="387"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="435"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="494"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="510"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI12468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="523" mass="58898" checksum="D315F1B325EB7E2A" modified="2018-11-07" version="1">MSSTPGSKPAVTPRSSPKKKPNKKRRNTNKKEANGETHPDSDEQDGPESPVEAANAAEIQDLQDKDAGNGHVVEPTEADPTVKLEAMGKEREALRAEVAQLRRQLESIQESHEQDVSQLRSDLDESNTAKEQAEEQYQNLLGRVEKIKESLSDRLKRDKAELEEARERIDELESQNEDLQSSARDADKLREELQTATRELTTLRSRNNLSAHNWLREKEELMKTVQHLKEEMETTSTAMGEWEVLAMEERSIKDSLVDKVSELEERATTLQEGYESACAERDSQATLVENLRNALWETQEARKKDLREVVEKTEAQLRTQEQVLQEAVARRSEAEKAKEELSKELARTAPFEKEVKEKNLLIGKLRHEAIVLNDHLTKALRYLKKTKPEDNVDRQVVTNHFLHFLTLDRSDAKRFQVLQVIAGYLNWTDEQREQAGLARPGASSGSLRLPPSPFHRTPSSPWMGPDIFSEPTSARDKESLAELWAGFLERSAREGAGDAPASSRKDSLGSVATGTGRSESGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDG7</accession>
    <name>A0A367LDG7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDG7"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="152" mass="17213" checksum="0322062B45A7704A" modified="2018-11-07" version="1">MYVFFSFSILCPQETDSASLLPFHLTDRCRALLLPCDLHRFANVAPPLPLVVLVSFIKTNECLRIPEGREGAVFCCVSPKRRDLLAYIVVIRFVKRYSALRQMEEKRGESKRAWVGSSARPKDYRSEPEMAELEGHLSEGLKASLSPLGSWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDT4</accession>
    <name>A0A367LDT4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytidyltransferase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_1217</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDT4"/>
    <dbReference type="STRING" id="1330021.A0A367LDT4"/>
    <dbReference type="OrthoDB" id="3558741at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI12577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="37137" checksum="1D67BC31EA2711DE" modified="2018-11-07" version="1">MKRQHPVSRISRHILGRLALNIQAAATEQGLTLDQEAPLNGLFLQRQAAPPNRLLLYPGSFNPPHRGHKALLQHALAVDTSLLGAIIVLTDDERLATKNRRDQRPFLLSKSKRVSLWRGASSDLGPNRVWVFDGSEDSWKALRASLQTRLAREGFRLEFVLLTGPDLVTSRRVADPSAWGCVEAITSDVSRPADFRCVHSLRQLPRCTPWEPSSSTETTDIRDPLGYPMTSATALWKCQTSTRPIRRYRFAVADTDAASAQREAPSSTEIRRVIAELDGSHLESELERLALSPTLLMRYASEGGPYTVPVVRAEKYQDHQTRKAMADEQATW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LE64</accession>
    <name>A0A367LE64_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">fructose-2,6-bisphosphate 2-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_0343</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the C-terminal section; belongs to the phosphoglycerate mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.46" evidence="2"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LE64"/>
    <dbReference type="STRING" id="1330021.A0A367LE64"/>
    <dbReference type="OrthoDB" id="267323at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000005">
        <property type="entry name" value="GpmB, Fructose-2,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000644">
        <property type="entry name" value="GpmB, Fructose-2,6-bisphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF44">
        <property type="entry name" value="6-PHOSPHOFRUCTO 2-KINASE_FRUCTOSE 2,6-BISPHOSPHATASE LONG FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="6">
        <location>
            <begin position="10"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI12711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="443" mass="50842" checksum="4C2ED07F867F1445" modified="2018-11-07" version="1">MPSKTDNGIGVQVEDTKICVVMVGLPARGKSYIAQIAQRYLQWLSVPAQTFNVGNYRRNDAPQPSADFFDTNNAEGERKRRAAAEAAVADMLSWFRAGGVVGILDATNSTKERRKWVSDACAAHGIEVLFVESKCDDEDIIMANIRDVKTTSPDYRGQDPDDAAQDFRNRIRNYEKIYKTLDQDGDEDDYTYLKIMDVGKQVIINRIQDYLQSRIVYYLMNLHIRPRSVWLSRHGESLYNLDGRIGGDTLLSPRGELYARKLPELVRESVGDDRPLTVWTSTLKRTIATARFLPPYYNQLQWKALDELDSGVCDGLTYQEIQDRYPEDFEARDEDKYNYRYRGGESYRDVVIRLEPIIMELERSEDILIVTHQAVLRCIYAYFMKKDQAKSPWMNVPLHTLIKLTPRAYGTEEVRYEANIPAVSTWRGKGSTAKHENPTDSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEU1</accession>
    <name>A0A367LEU1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutamine synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_0937</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEU1"/>
    <dbReference type="STRING" id="1330021.A0A367LEU1"/>
    <dbReference type="OrthoDB" id="77835at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006576">
        <property type="term" value="P:biogenic amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.70:FF:000013">
        <property type="entry name" value="Glutamine synthetase bacteria"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.590.10:FF:000005">
        <property type="entry name" value="Probable glutamine synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785">
        <property type="entry name" value="GAMMA-GLUTAMYLPUTRESCINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43785:SF12">
        <property type="entry name" value="TYPE-1 GLUTAMINE SYNTHETASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS catalytic" evidence="8">
        <location>
            <begin position="130"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI12936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="485" mass="52935" checksum="5F41AAF905FCFE63" modified="2018-11-07" version="1">MATSAPSATASTPPNLTVAALPKLLERDSRVKLAGLDVDGILRGKLVSKKKFLSVAEAGFGFCSVIFGWDMHDQTYGRELGVSNAANGYRDMVAVPDLASFRRIPWENNVPFFLVSFLDPDTRKPICACPRGLLKTQLDRLRAGGCGAMAGAEYEFYSFRSPGSSPAVFLQQNPPEQLPSLTEGMFGYSLTRPVHNKKWYYDIYDACAHFGCDIEGWHTESGPGVFEAALEYNEAAEMADRASLFKYAVRSVGAEHAITPCFMAKPRQGLPGNSGHIHVSIVDDSGKNLLAREEGNDSGEAEYDDVAGLSDLGRHFLAGILIGLPDVMPMLAPTVNSYKRLVENFWAPVTVSWGLEHRAASIRIISPPTSKASATRLEVRVPGADTNPHYVLAAILGCGWRGVERKLELPCPPLSSGQSVADGDGQRLAKTLKEATARFTAKDSVARDVFGHDFVDHFGGTRENEVRLFEEAVTDWEMKRYLEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LG38</accession>
    <name>A0A367LG38_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_1225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LG38"/>
    <dbReference type="OrthoDB" id="4908214at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI13393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="343" mass="38726" checksum="AFDCDA09F5F3BDBA" modified="2018-11-07" version="1">MVANPALTLNYQVAGSWGPVRADSINIFPSSLTTSEWLYHCGPIPERIRKRPWELIMTSNSLANGPLNLEHDQVVDWGLYILSMLPQELQDNDLWRQEREEIRDNINLETGDSYMVARLNKLASWLWDQREARAFVCWPNDEVMRYIRSLASYTDGVANLFASDVSLEKAHAGWNAVPWTIDSVSLTVVHCLDSKDKFFKDVAIVLAKSTVTSGWKFGTTRIRTLREFLVKHHDPFLKAVGMAVLPSYTCSDGDRCRQHLLLGKAYLPKDWEDLLAKIRKAIGAGLTVCLKRGRVEMSNAHVYIDMGKARALADILADETRVKPTCTEDIWADLTSIPFASAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGH5</accession>
    <name>A0A367LGH5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cation-transporting ATPase</fullName>
            <ecNumber evidence="14">7.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">L249_5504</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CFA/CMAS family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.-" evidence="14"/>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LGH5"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07542">
        <property type="entry name" value="P-type_ATPase_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000032">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000064">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000057">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000068">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000554">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047819">
        <property type="entry name" value="P5A-ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047821">
        <property type="entry name" value="P5B-type_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF8">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02353">
        <property type="entry name" value="CMAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12409">
        <property type="entry name" value="P5-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="237"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="597"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="629"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1151"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1191"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1223"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1254"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1291"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="domain" description="P5B-type ATPase N-terminal" evidence="17">
        <location>
            <begin position="218"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="16">
        <location>
            <begin position="454"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="129"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="775"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU362082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF12409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RCI13511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1689" mass="189420" checksum="7129AB254056D714" modified="2018-11-07" version="1">MNAPDAVQTRHDNSEEQNCRLTIANASLMNDDECPAERRLNGSLSGTGTLPSTLYRLNSNQSSSSVFEDVEMAQEEQYSGPMAESFPSSASAFSHRRARATSTTSFSFYDEEESAPFVTFYDQEYARSRRSTNDGYTGRNIGDVDEAADSDYFPSDEQGQADDDPEFPSHDYPPSTDSALQSQDPSQLHLLRRDSVATAASLCENSGRTSQKLYMANEDLTIAIAGFRTGRVGRATYVLLCVLTFGLAFLLFRWLPRWHVAIIGRPRPLRDCDWVVVENQWGELVILSVRTQLYGRPVSTTFGMPVKLFSYGLDDESDPLMDQLRTLEYRHVRLCFHPLQDQFVLSTGWKDPDWTNIRSLRSGLDSDEKATREVMFGSNLIDTGVKSVGQLLVEEALHPFYMFQVASLVLWSMDEYYYYAACIFIISVGTIVATLVETRATMKRLREISRFECDVRVLRNGFWKFVSSSDLVAGDVYELSDPNLNLLPADSLLLSGDCIVNESMLTGESVPVSKLPATDQTLKILDLGASSVSAEVSRHFLFCGTKIIRTRRPQEDHGGDAAALALVVRTGFNTTKGALVRSMLFPKPSGFKFYRDSFRYISVMAAVAGVGFVASFINFLKLGLEWHLIIIRALDLITIVVPPALPATLTIGTNFAISRLKRKQIFCISPQRVNVGGKLDIMCFDKTGTLTEDGLDVLGIRVVMPDTKTFSDLISTPLLVESKRSARSASSSALKAVLHTMATCHSLHAIDGELVGDPLDVKMFKFTKWSFEEGRQGTAEGEDEEQGSLAPSVVRPPDGSRELGMLKSFEFLPQLRRASVIVRHFGQKSGDIFVKGAPEAMREICREESFPSDYDEQLSYYTHKGYRVIGCAMKHLHKLSWVKAQKMHRSQVESELDFAGFIIFENKLKPTTAAVLKELSNSGIGAVMVTGDNILTAISVARESGLLDRNAHCFVPRFTRGDARDPAAQLQWESIDNSGYNLDSSSLLPLPAPPEVDASLPYEVFNIRNYSLAVSGEAFRWIVDYAPSEVLRRMLVQSKVFARMSPDEKHELVDKLQSIDYCCGFCGDGANDCGALKAADVGISLSEAEASVAAPFTSRVFDIRCVLEVIREGRAALVTSFSCFKYMSLYSAIQFTSVSFLYAKASNLGDFQFLFIDLLLILPIAVIMGWAGPAPTLCRKRPTADLVSRKVLTPLLGVMGICPWYLAPKIRHDESNIKNSENTALFLVSCFEYIFAGVLLNAGPPYRQSFTQNWPFITTIALALLATTYTVLAPARWLGELMELTPMSWDYKLFLVGLGISFLSLSWVYENYASMALSRWLGVTARRLMGKEKQRKQYKEIQVWRDEYLTDETTTDWILDGGYLPHAVIRVGIRRQLRERLSSIQATSFSEALESKMAYIERLRRQPIAIETEKANEQHYEVGTGFLAACLGPRMKYSACLYPKGNETLAQAEEAMLQLYLDRAELKDGMTILDLGCGWGSGALYFAEKLPNARITAFSNSRTQKQHIDAEAHKRGFKNISVITGNVVNYEFEQDKFDRLFEHMKNYELLMAKVSRALKPGGKLFVHMFAHRTTPYDYEEGWMTTHFFSGGTMPAADLLLYFQEHLQVRRQWWVNGIHYSRTCEDWLSSMMANKKQLMPHLTETYGDEKAVTWYNRWLVFYMACSELFAYEGGDTWGLVHSLFVKASDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHA0</accession>
    <name>A0A367LHA0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHA0"/>
    <dbReference type="OrthoDB" id="5124663at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="237" mass="26341" checksum="22B5BE19A330B3F6" modified="2018-11-07" version="1">MTIIRLLSTHPLPLPLRRLASSSASSYRAFTPESAKQFVFKGKLRTTPQNVLFFQKHDIEPDNSRLRIYQAGPELKKVSKDYGITFFHSPKHVLSPFALVYFDPRGHPLAASVKAKLAKKVRDEPLWVQCTSVSSPTSAIVHTLAKRRITAAIHRALVERGYNQAPGKGLGKTVWGTLYMKISDPLKASAQPPARLGTVVAEAIDNNWPCRVGGGRPRVMANAPKNKKMTRDRPILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHE2</accession>
    <name>A0A367LHE2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_8312</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHE2"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI13856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="192" mass="21399" checksum="CF9F60BC4EE7B95F" modified="2018-11-07" version="1" fragment="single">TIYTATLGALVTVATWPEGVSICAARNIYKVFLLDEDKIIRARNTPANPNLDKSVTHIANVSKDNNPFDPNDFFYYYIPNPYLHPPEHSAYSGVGDYSGRVIAVIAGIMGSDRSDRSDRYVQVFLQITNLLRTLKYLEKIISISFSHLLNTNTSPASNSSLIASFRLLRDSSSSSLLRDYLPDSSTLYLLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHJ6</accession>
    <name>A0A367LHJ6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_8268</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHJ6"/>
    <dbReference type="STRING" id="1330021.A0A367LHJ6"/>
    <dbReference type="OrthoDB" id="2156052at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052396">
        <property type="entry name" value="Meiotic_Drive_Suppr_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37171">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE YRZF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37171:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE YRZF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="562"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="724"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="492"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="734"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI13867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="767" mass="86423" checksum="A3CBE6DF420F2F5A" modified="2018-11-07" version="1">MDDLEVLRRRIRDVESERDELKRQGDEEKRRADEEKRRADEEKRLREAAEKAAEPMKLLTLEQYLESCHSIHLGIQVETRKSRTTQGVPTNPVGRILPRRIIPWDDFATKQEETWNGLSISDLFRVPAFPSQHQLDYVSSFLRPISSELGLRRFEHDVVENAVQKLFDRVNADPLLRNSLGLQGTVTFESHTNFGTLDDDPLSESMEHLSLSQGPTPARKPKARRRAKGKGSLADQYCIYRTAGNQDFPMLAIEYKAPHKLTMDQVVTGLASEIQPQRDVINKDGQGFTFQARRLTAAVVTQLFSYMIGKGMQYGYICTGETLVFLYIPKDPSTVYVSVCVPNQDVMDDDETRLHRTAVAQVFAFILRALRAEPLPESWFDEAEKLETWAVEYDDILRHIPETERKKGKEPHFSPYKPQSWKGFQRSPIRTRSRCQPPDPGLGRPSDDDEDDGPPSPTPGPRRTVAKAAPSTGTGSGGGKKSERGRDKQVQSPPTTKSAPTTKPNIRIRPYCSQDCLLGLAHGGPMDKNCPNADDHGQKHISRAKFLRLVRSQLATDRGCDADCAALHLTGARGSLFKVRLSSHGYTLVAKGVEEMDLDCLQHETDMYKRLRPIQGKHVPVCLGIIDLVLPYYYDSGVYVHFMFLSWGGQSVLISEDPAIKSGMDSAVGTILKAVHGLRVLHRDAEPRNIVYDESCGRFMFVDFERAEFRGRQRQPLGSVAVNVASPDGKRKRGTLEEKEKQKGDDKAFARELDSAKYMASRYTARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHS4</accession>
    <name>A0A367LHS4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_8181</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHS4"/>
    <dbReference type="STRING" id="1330021.A0A367LHS4"/>
    <dbReference type="OrthoDB" id="760868at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000244">
        <property type="entry name" value="Nonsense-mediated mRNA decay protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013713">
        <property type="entry name" value="XPO2_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF18">
        <property type="entry name" value="D-IMPORTIN 7_RANBP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08506">
        <property type="entry name" value="Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016975411" description="Importin N-terminal domain-containing protein" evidence="8">
        <location>
            <begin position="19"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="domain" description="Importin N-terminal" evidence="9">
        <location>
            <begin position="99"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="28"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="995"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="995"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI13949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1135" mass="129061" checksum="B7C39686A4FA0430" modified="2018-11-07" version="1" fragment="single">SRSFSFISLLLHFLGLFALRSRAPPPALRHRSLRRHSPRPPPDPPLGSTLEASAPRCPTIRSPCPERISKKTPPVMDSVAVRGLLLASLDADADNRRRAELQLKQVEEHAGFMDCLFQILQAEHDTSVRLSTVIYIKNRVTRSWFPCEQFANETLIPEDEKARIRDMLVPILASSDGPVQQQLIPVLQRILQCDFPARWPRFVDFTMELLNTNNPRSVHAGLQCLLALCRAFRYKSSETQDRPQFDTIVETSFSRLIVICNELVTQESDEAGEMLHLALKAYKHATWVPPAIPLELSPHLRQRQVNIAWCTVFLQAVSKATPASALQGDQFDREKNHWWKAKKWAYFNLNRLFIRHGNPATPGKATEATEFANDFITTIAPEILKHYLQEIEKWVAKTSWLSRPCLSYTLVFLDESVRPKEMWAHLKPHLTNLVTHFVFPVLCLTPDDVEQFEEEPVEYLHRKLNYFEEVSAPDVAATNFLVNLTKNRRKQTFEILKFVNAVVNEYEQSPDDKKNHIAKEGALRMIATLAPVILSKKSPIANQVEYFLVRYVFPDFTSAQGYLRARACDTIEKFEQLNFNDQGNLLAIYRHILDCMADPALPVRVTAALALQPLIRHDVIRTNMQQSIPTIMQQLLKLANEVDIDALANVMEDFVEVFATELTPFAVALCEQLRDTYLRIVRELLEKESRAGEDGDAYADYDDKSITALGVLQTIGTLILTLESTPDVLLHIEAVLMPVIKITLENKLYDLYNEVFEIIDSCTFAAKSISANMWQAFEMIHATFKSGAQYYLEDMLPALDNFVQYGVPQLVQKPEYVQALYSMVADMFTDSVQGGVERICACKLSEAMMLSLRGHIDTCVEGFIVMTMNILAGDEVDNKSYKIHLMEMVINAIYYNPLLALQVLESKGWTNRFFSLWFGSMPIFSRVHDKKLCIVAISALLSVKHDQVPVSVCVGWPRLLQGITELFRTLPIAMRNREEALRDDFHLESTYDYGDEDEWGEEDANWNGEEEPAQPEALTTRDESKTYLDFLNDEARKFSRAIDGGGEDDDLGEDSIPLESQLDKIEPYQTFKSIIMRMQQEQPQFYASLAGHLSAEDQSMIQTVMNKADEIAAQQAQDLLTQQQGQMAANATQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LI33</accession>
    <name>A0A367LI33_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI14096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LI33"/>
    <dbReference type="STRING" id="1330021.A0A367LI33"/>
    <dbReference type="OrthoDB" id="4913784at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="307"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="445" mass="49546" checksum="6EF49358AFDEA26D" modified="2018-11-07" version="1">MQLLAKPKCIWRGRLYRGFCTKTLPIPIYDPYPQRVATTRYLKRSEICGQASSDGVNPGPDCCRAYGKPCAMGFQELWCEAFPVESRRVLGVAHSAETCAYQDRVCQWHGQSLSCGGSEFSGLEWNRYNDHQRQLVLSTEEASLAIMCSRKGMGNPGKECCDRRKPIPIPLLHHHPDIPEVAPGLRLVHGRYEFQGPAGGMAKVPHTPDEIRSRLESLEKDVWRRETDLGLNRPTKTAASLDDVELDAKIQDSAKAQHKAWKLFKSEKAETFRHQSVQIGILTLTYRQIADLKKDLVKAEAAAVKPSSSSSSSSLSSGDNAGAGPPLSPAFYRSLHSKQQQQQQQQQQQQQQQKQQQQQPSRPQPTRKPSPPTKGDDSLKPDDSTTSFSSSKRPAAPPSRKPPYHNPQPQRAGFTPPKNSQFQNQIQSQAIGLKIVKGHQRSASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LI74</accession>
    <name>A0A367LI74_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein O-GlcNAc transferase</fullName>
            <ecNumber evidence="3">2.4.1.255</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_8127</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.255" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI14110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LI74"/>
    <dbReference type="OrthoDB" id="421121at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097363">
        <property type="term" value="F:protein O-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000552">
        <property type="entry name" value="UDP-N-acetylglucosaminyltransferase (AFU_orthologue AFUA_1G03380)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029489">
        <property type="entry name" value="OGT/SEC/SPY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44998">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44998:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13844">
        <property type="entry name" value="Glyco_transf_41"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-GlcNAc transferase C-terminal" evidence="8">
        <location>
            <begin position="940"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="domain" description="O-GlcNAc transferase C-terminal" evidence="8">
        <location>
            <begin position="1104"/>
            <end position="1310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI14110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1333" mass="148459" checksum="2B2406657B2CAC08" modified="2018-11-07" version="1">MPKSRVPHRGCLSTRLCLLKPASRFLHTVAGVHYDLRTIYLPPSPTIGLAAPNCNAWQAQLSPGERTTTVQHFRGRLSNEDRGPVPVMRRPGIYKPAETRGSPCSLYPSHARHVKKRNTECSWNFDIITANSAAPFPHASNKIDHAEIRRKTLASARECYIKLLAYLQESGRYDLLKTTSRFSVNYGGSSQAGIPNPATGLLQYSGESVHPSSNGSTILPDGSGFLHLQLRPVGEKPSSHGSYARHLGGSILTSSDVEYDRHASIFNPVTSDSASHPACFSPLSAARSSLHMLEILCEQSDWQWIDGILLGGCLQYGLEYYEGALKWFSRILELDASHVEAITNTAASLFCLDRQTEAEQLWLEAVRLRPSYLEALEHLISLLYKRRSEEAIEVISYVQRSLRIPSQMSDRPEYVHGSSHCSSGYRLPASENGRILALLHAKGTMLYSLGKIDRASEAFEEVVLISTGCQFRGIHDLTRHIQFVLSSRGSDMIPGICQNQPYQPSMLPPEMARRTAQLVFSGNGDLPGLLPLRSDTAKKAALQTTSNSLLSLAKILQDAISSGEAKPHSPRGASGVGDILALYYLSLSLQESPSTANNVGILLAGIQQTSSIPPQPLPRESCQPTLPSATPGSGMALAMAYYNYGLRLDPNHVHLHTNLGSLLKDMGHLDLAIQMYERAVLCDGTFDIALTNLANAVKDKGRVIDAIAYYRRAVTTNPGFDEAVCGLFTALNSVCNWRGRGGVFLSAGDYDRWHVDDEGKLLDARVCGGARGLAKRVVDIVAHQLRDASYWGQNILQEPVIRALDQQLQHLCEDSSFQLGAAIRQWAGKPWEERATKVALRKWYLDINVRGRGQTATDGASISYFYLSACGKRRASNKPAQCVEDILLNSAIVLASIHPDPATVTAESSLELGFLRCLLMAGLTRPYEECSRFLDFIIQIGDASIHRQQIESEAPVFRDFSGWSPERVVGQIGRDRIHILVNLNGYTRGARNEIFAARPAPIQMSFMGFAGSLGAEWCDYILADKTAVPPATLRPWRRNVSIEDVFYDNTDCSEGEWVYSENVIFCRNTFFCCDHAQSNGRNEKGISWEEEKRRRWEMRQKLFPRMPVDTVILGNFNQLYKIEPTIFRSWLRILSRVPNAILWLLRFPEPGERNLRATAEAWAGPEVAKRLVFTDVAPKNQHISRARVCDLFLDTPECNAHTTAADVLWSCTPLLTLPRYPYKMCSRIAASILQGALPRSAEGRQVSTLLIVEDEAQYEQRAVDLAGNLVYVQADRASYNEGRGKLADIRQILWESRWQCGLFDTRRWVEEVECAYEEAWRRWVEGVGGDIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIA5</accession>
    <name>A0A367LIA5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein S11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_5914</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIA5"/>
    <dbReference type="STRING" id="1330021.A0A367LIA5"/>
    <dbReference type="OrthoDB" id="1654884at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_uS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="20"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="113"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI14151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="39946" checksum="D5A709A94A4C67D7" modified="2018-11-07" version="1">MSRALAGRPALRQVFSASYPSRRSRFLSQTAASWRDEEPPGASPKINPLTTVFQPGAPPVESRKDTRDELYASSLHNLSPYDSDITGQSSWQSDSDYSKVAGTLYASSQTAGYDFSKPEQSQSTSGYRTGAGSAIYNSDLYPLKPDSARSSSEWSRNLNSSLYGQRQPTMAAKDVQTTNEENKRISEGLFGARQTVNSRAGRSDPAHYDAFESLRRSTPVDTKVLDNPLEQSVDEPPPSVEPHHLHVYAHKHNCHITLTRPNRDPIISLSCGNIGFLKANRGLFDSAYSLAKYVFERLMQKNIKINALELVLRGYGEGRQAMLKLLLSPDGAFLRHKITRVSDSTRLKFGGCRSPGRRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIE1</accession>
    <name>A0A367LIE1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI14022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIE1"/>
    <dbReference type="OrthoDB" id="4925605at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="202" mass="22439" checksum="6FD3E6BEF3E6C880" modified="2018-11-07" version="1">MDPLIGNEYCCAISPPAAPEFCLHIALFYRRCRRTRALATPAPPPSPQQNRRLPVATAQPSNSNYTVYRLIYGPDSRPRHRFFVQTTVVGSGRGLYLYIDEGSSGYSESPGEDPLLQHPSSSPSHSLRAKMLVGTISPHNLERFRHLCRRLAPSDAARETVELCSYDWIQEAIAHGVAEGIIDVGLRPRLIGFKGSFKDVYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIN5</accession>
    <name>A0A367LIN5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Obg-like ATPase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_5922</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIN5"/>
    <dbReference type="STRING" id="1330021.A0A367LIN5"/>
    <dbReference type="OrthoDB" id="424823at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.300:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="entry name" value="TGS-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00944">
        <property type="entry name" value="YchF_OLA1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00092">
        <property type="entry name" value="redox-regulated ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF11">
        <property type="entry name" value="OBG-LIKE ATPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="5">
        <location>
            <begin position="153"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="6">
        <location>
            <begin position="438"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="41"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="162"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI14296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="526" mass="58253" checksum="04503B8603E9709C" modified="2018-11-07" version="1">MRSFVAVGPNLNLQPTVHHRHLLRILIKPVFTIVSSSIVSSSSTLSPPPSSAFSSSSSSSSSSSSSSSSRPTSRSTSRSTSLSSSSSIFTSLLPCLPPHHHHHHHHHHHHHHFSLFTLTPRRHYAKPRRNNRMPPKKAAQEEKIPLGRPGNNLKSGIVGLANVGKSTLFQAITKCSLGNPANFPYATIEPEEARVIVPDARFDWLCQKYKPKSQVPANLTVYDIAGLTRGSSTGAGLGNAFLSHIRAVDAIFQVVRCFDDAEIIHVEGDVNPVRDLDIISEELRLKDIEFVEKALENQKKKTRMGGQSLELKKAKLEQDMIEKILAWLKDGKDVRKGDWSPKEVEVINPLFLLTAKPVVYLVNLSEKDFVRKKNKHLPKVAEWIKEHSAGDPIIPISVSYEERLTRFESEEAAKEEQIKVGADSALPKIITQMRKTLQLGSFFTTGADEVRQWTIRIGTKAPQAAGVIHTDFEKTFIQAIVCSYDSLKELGDEAEVKARGKMMTKGKEYVVEDGDILLIKAGAAKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIR6</accession>
    <name>A0A367LIR6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 14">Inositol oxygenase</fullName>
            <ecNumber evidence="4 14">1.13.99.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 14">Myo-inositol oxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L249_5915</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 14">
            <text>myo-inositol + O2 = D-glucuronate + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23696"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:58720"/>
            <dbReference type="EC" id="1.13.99.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="13 14">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Polyol metabolism; myo-inositol degradation into D-glucuronate; D-glucuronate from myo-inositol: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the myo-inositol oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.99.1" evidence="4 14"/>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIR6"/>
    <dbReference type="STRING" id="1330021.A0A367LIR6"/>
    <dbReference type="OrthoDB" id="5151075at2759"/>
    <dbReference type="UniPathway" id="UPA00111">
        <property type="reaction ID" value="UER00527"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050113">
        <property type="term" value="F:inositol oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019310">
        <property type="term" value="P:inositol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007828">
        <property type="entry name" value="Inositol_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588:SF0">
        <property type="entry name" value="INOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12588">
        <property type="entry name" value="MYOINOSITOL OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05153">
        <property type="entry name" value="MIOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 14" id="KW-0408">Iron</keyword>
    <keyword evidence="7 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="12">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="106"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="165"/>
            <end position="166"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="242"/>
            <end position="243"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR607828-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR607828-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCI14152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="308" mass="35675" checksum="6C641ABB0C1BC3A9" modified="2018-11-07" version="1">MAPAALVENPPSVSHGLDIDSISDAIDDVNCIKYDATSAFDSNKDKTNFRQYNDACDRVKTFYRTQHERQTVAHNLAARNRFRNPLRVRPEMTIWQAMEKLDTLVDESDPDTSLSQIEHLLQSAEAIRRDGKPRWMQLTGLIHDLGKLMLFFPELETQGQWDVVGDTFPVGCAFDQRIILSETFASNPDSDDPIYKTKYGIYTPNCGLDNVMLSWGHDEYLYHVVRDQSTLPDEALAMIRYHSFYPWHREGAYQHLMCEKDEAMLKAVQAFNPYDLYSKSDDVPSVEELKPYYLELIDEFFPRKVIKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIW0</accession>
    <name>A0A367LIW0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIW0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="96" mass="10760" checksum="2037F00C69D9DA3C" modified="2018-11-07" version="1" fragment="single">TLRRCKADVITPTLFPRGILDLYLSYRSARTFQLLEANSIAAGIRAACARYRRGRDRRAPIPPLPPHERLETPALQPRPPEGPGQPYSSTQPQGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJ87</accession>
    <name>A0A367LJ87_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_5921</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJ87"/>
    <dbReference type="STRING" id="1330021.A0A367LJ87"/>
    <dbReference type="OrthoDB" id="2100128at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39398:SF1">
        <property type="entry name" value="CSN8_PSMD8_EIF3K DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39398">
        <property type="entry name" value="YALI0F14311P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="377"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI14496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="594" mass="67461" checksum="211AFB5F56A164C6" modified="2018-11-07" version="1">MPNRGGRAPSGPWSRLKPLEQDFLESYGLPSKGDNRLLDFKLQEKYYTKIVERYMTFCSDAGRGDELLRRFSALEWAPDSTPMSTPSAVPSPSFETLQSPEKSNALSGVLEALRKLREAIVASGRADDFAVQAYLFCIRLSVLVKRADSYHPAVLHLLRSMHPRHPLTSVEVQEVAGYLVLDTACRRRQLSEAFELRRRYGLRDAKVGVVLSAMVHDDLFAFSRVKRAVDGHCARIMEWAEADLRMHALKCIGQTYLQLDVDFLERVTASSWDELKKRDGVGWELNWSCRGNSQAIYHELQTLSGFHNHYKRRRKSKIPSSKPLLRTSGKGRQGEEEDTGERNDERTRPQRGDDRNKTSSVVLSDYRTCWLAKTDQPAVELEAKGESFAVHKSILTTHSEYFAACLSKSSFVEAAENKVMFDDVEPLYLGYYLGVAASYSSIVPHVPPTPAQNPEACVKRTPMRDFVEVYKLCDRFISIDIGIFMIECIKTTIGNGHRALFRAQADEGQQRALMRDFADGFEALNLQHPEQNMLGKTMIEYFCEGIHYPTWIAYVDEFLDSPRFVGHVSKGFARKLDNAIHSRAKLRQKELKGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJY9</accession>
    <name>A0A367LJY9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_6685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJY9"/>
    <dbReference type="STRING" id="1330021.A0A367LJY9"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="97" mass="11224" checksum="6BBD33A4F8AAF612" modified="2018-11-07" version="1" fragment="single">KIRTDKATFRDKEDRIGFLFRSLEGKARKTLETYLLTKTKDDSLSYEDFYSYIKDSAIKRLDAELVLPNNLPALTKYSLSILLPKTPLLNRQIDPAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LK50</accession>
    <name>A0A367LK50_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_6398</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LK50"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="209" mass="23309" checksum="739132EE1D82AA23" modified="2018-11-07" version="1">MPCAIGLGWQNRWLYRKGGKSAQETLEQLPTALVLMISRSFVSNTLYVRLFKLNEPVKGRMKCSTLVLGFLVGVHAIPIKEHSGSDTTLLHEFAVPIGSQEIDISTEAAVDRMQTSPTDCSPEDSVLSGCFGEFLNHAKKDLALLLVKGVKIAAKKFKVGGEDLWHHAFFMSCLRRIHVYTRIPTQVVMHVHLTRPSKLPHLPSRPQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKE6</accession>
    <name>A0A367LKE6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_6516</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKE6"/>
    <dbReference type="STRING" id="1330021.A0A367LKE6"/>
    <dbReference type="OrthoDB" id="4770059at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI14847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="31997" checksum="8BA48B03573AE37A" modified="2018-11-07" version="1">MEIAITPQPRSTTEQRPTTTTTTTAFISSFTHNPLTTAFPRPNDCHGIYRSRFLAMIDLTSTCLPPRLRTSPDAYFSPGISCPAGYVTACHDNRGHASITTVTCCPTFARGVTLSCVTTSTLKSIWRTLFCTWIAPAGRGTSFSMTLSDNGVTSTVEHGFRSPGGLNAFGIRMVYQQTDVNARNGHHTTSTAAATTTTTTTTTTTTTSSDSSDQALSTGSKVAIGIVVPIFIILLLLLAVMQFWRRRRRRYQSQEETHPHEKHPTQELHGENVQEMMGSTADVAELPAMSTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKG1</accession>
    <name>A0A367LKG1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKG1"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="84" mass="9761" checksum="C81AD92B59C83925" modified="2018-11-07" version="1">MGSDRSDRSDRYLSDSGYLYTFNLFFTAFLFTFRPTNYLIRTLFSDAFQQTDPLFLKKFPLSAIIGNDQKYSFAKLSGSGNYTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LL99</accession>
    <name>A0A367LL99_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_6441</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LL99"/>
    <dbReference type="OrthoDB" id="5421at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045815">
        <property type="term" value="P:transcription initiation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05491">
        <property type="entry name" value="Bromo_TBP7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001218">
        <property type="entry name" value="AAA family ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000061">
        <property type="entry name" value="ATPase family, AAA domain-containing 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045199">
        <property type="entry name" value="ATAD2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23069">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23069:SF0">
        <property type="entry name" value="TAT-BINDING HOMOLOG 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="625"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1081"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1283"/>
            <end position="1558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="259"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="281"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="365"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="402"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="496"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1081"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1294"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1336"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1400"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1431"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1457"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1474"/>
            <end position="1485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1489"/>
            <end position="1502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1516"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1548"/>
            <end position="1558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI15198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1640" mass="181006" checksum="30D3EF6A272F0206" modified="2018-11-07" version="1">MVNKRKRALEEFDPNKSDSEDENFDPSAARPARSSKKPRSSRTVRTGRKSSQHYRGSDIEDDEEDESSESQEDFFEGDESEHDQNAPVNAAGRRTRKAAINRTNYKESSEEEDESAGETEKAPETGNEKGAKRKRAATQDDDEQGKSKTRRLVRLKVPKSATLPPTTRRSTRASTAESDEFVELSTSGRHVVPSRDSVSKSPETHNRTLRSSRALKGLKSAPEPIEPILEATQESSVLPSNDVDDEDELAKDDKPAEQGDMETNEAAEEADDVEAAATKDGNADHEEGDVVDKNNNDDEDEDEDDDVPLTRRTRSGRAGVVAAEEGNSDGADQTTRRLTRGARIKKSTQEPSSDFEPGDDSDDGDMSKSENGKGQEDDDDSPTPRATRRSQRTSGRGRGSVDEEPEFDLEELNEEARELRQSSRPRRRPRQPSPIVYQENTRRSRAKVNYYMPPLTAVNIDDEEEDPAPTPIRNRRGKGGGGGGGWERNLNTTFGPFGGGGGGGSILGGPWGTGAAGGADSDSSDDEMVHRSSVAANVGMTPTSAAPGGFLPGAQGLNAEGVGATPNVGKIKDRKALADADPLGVDMNVDFSKVGGLQGHIDQLKEMVQLPLLYPELFTKFNVTPPRGVLFHGPPGTGKTLLARALANSVGSGGRRISFYMRKGADALSKWVGEAEKQLRLLFEEARKNQPSIIFFDEIDGLAPVRSSKQEQIHASIVSTLLALMDGMDGRGQVIVIGATNRPDNIDPALRRPGRFDREFYFPLPDVEGRRAILDIHTQGWGLSEAFRTSLADKTKGYGGADLRALCTEAALNSIQRTYPQIYSSRQKLVVDADKIAIHASDFMMCIKKMIPSSERSASSGAQPLPNAVEPLLRAQLHKAKEALDSLLPRRKKLTALEEAMYEPYEDQDHGFGREMMQQEFERSRVFRPRFLIYGMPGMGQGYVSSAILHYFEGVHVQNFDLPSLLADGRPLEQVIVSFFTEVRRHKPSVIYIANVDAWYAALAGTIAFVTFQTMLKSLPPTDPILLLATAECGRGELPVELSRELFGFSRKNRMEITRPERANRMEYFETTLSYVKRKPAEFPDPENRKRRKLEELPTAPTIQPRAPSKMEKKAVQKKDHQLLNGLKIQLQPIMDQINRRYKKFRQAVIPQSQIEYLFAESDPNFVRPDIAEGEVRPFEIVKDKYGNDVLRDTATGKCFYNLETTTIEERLSNGFYARPKDFLFDIKALARDAKNIGDKERTLKANELLSNVEVDVAGIELSTAHLDWEGLYHRQIQRAKEAADKERKRKAMQSITDRFQSEQTGGNDSDSQGPLTLGEMVPGSRTTARFRLRSPPTNGQGSQSQVAAPETPRQQFGLSNGTSASPEGAKDADVRMSGMGDESAQASAMGPPPRSDGDQSMSKQQTQMSQKSAVTSLPAGVSPSAVLNEAASTKTSDRSTQQRSSNWSTQLTNGNHGERHRESHDSEGELPNTLRTPNQVSSSDEPWPQSQAQAPARSQAAVDGAPPPRSQEGPQQGPQKQQQQQQHQHQQQQQQQKPQQQQGQQQNAGRNSGSTASQPMSVEVAVDGFLIEVTDGTSGCTIEQLEQINRELMDEIWRRRHEWNRLKVLNQVTGIFNDTIGEIESIQGMGPQSQGVELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLK0</accession>
    <name>A0A367LLK0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase eIF4A</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Eukaryotic initiation factor 4A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Translation initiation factor 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">L249_6968</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the eIF4F complex, which composition varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. eIF4A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLK0"/>
    <dbReference type="STRING" id="1330021.A0A367LLK0"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18046">
        <property type="entry name" value="DEADc_EIF4AII_EIF4AI_DDX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000089">
        <property type="entry name" value="Eukaryotic initiation factor 4A-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000031">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044728">
        <property type="entry name" value="EIF4A_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="20">
        <location>
            <begin position="24"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="63"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="244"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="16">
        <location>
            <begin position="24"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RCI15132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="405" mass="45866" checksum="A0A71B2B4981C1EA" modified="2018-11-07" version="1">MATDKGLEDVPEGQIESNWDETVDSFDDMNLKAELLRGVQPIDLVKVYAYGFERPSAIQQRAIMPVIKGHDVIAQAQSGTGKTATFSISVLQKIDPTLKQCQALILAPTRELAQQIQKVVVAIGDFMNVECHACIGGTSVREDMKSLQDGPQVVVGTPGRVHDMIQRRFLKTDEMKMFVLDEADEMLSRGFTDQIYEIFQLLPQSTQVVLLSATMPQDVLEVTTRFMRDPIRILVKKDELTLEGIKQFYIAVEKEEWKLDTLSDLYETVTITQAVIFCNTRRKVDWLTDKLTARDFTVSAMHGDMDQSQRDLIMKEFRSGSSRVLIATDLLARGIDVQQVSLVINYDLPANRENYIHRIGRGGRFGRKGVAINFVTADDVRMMREIEQFYSTQIEEMPMNVADLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLN4</accession>
    <name>A0A367LLN4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_6522</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLN4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI15328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="93" mass="10378" checksum="138C0DE18C0827FF" modified="2018-11-07" version="1">MIYYYYLKRERKRDASLQRPPGCRVKSEVNEFSYSRPVGVSTQKMTEAHAKVFQSSTEAAVAVRRGNRPVPYQGLEPLPAGCTSFDGQTGFAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLS4</accession>
    <name>A0A367LLS4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_6505</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLS4"/>
    <dbReference type="STRING" id="1330021.A0A367LLS4"/>
    <dbReference type="OrthoDB" id="1747771at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000001">
        <property type="entry name" value="Fungal specific transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004507">
        <property type="entry name" value="UbiX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374:SF1">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE PAD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="534"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI15359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="680" mass="75268" checksum="5D9B5186FD55968A" modified="2018-11-07" version="1">MSDETKALTPDEANRIIRSHRKVRYGSACWPCRQRKVKCDNKQPCENCVKREHTELCSYKPNRTATAAAAAAAAKRAHPTRARSLSADIARTGTSNWPRADLDNDTDAVSDRFLGQNSIPALLRREQPSSAAASDDGVYSILGLNTAAPFPFTSPRRLDLLTRDLAAEMPSDRDIISLFRTYKEVPQPFWGFVHDMDDLESKLMAYLEDRSGDKASSQPVTAPWLAILFAVLAVGAQFDDDPFAQRTHNCQKFTEISFHFLRVSNFLLRPSFDSIQALLLLGFVLLNDMKAEASWALLGLTSRLAQSLGLHRQRPSQGASPDDGVKEAIRRELHLKCLWHDTLSSLSFDRCPIMNFPPELSVSSDANPRLSYLEIMYGVIEIISCRFKPGLSTDPSYAEILSNCAAVENLRQLALPHLKDRAMCKTVLESLQCYAIRLHTCFLISVACRPALRRDCGGLDPQQRIDVGIKCKENLIETVKMFLAMNQLSCLPTRSWAFTYHALSSALLLSFLCDASDKETRQLQADLIRALSDTAADEKGSPGPRPSKSNKDIELSGPLWRALTALKQIYDHGSGLIQESDSPAGPSAIRLAVPPSRTAQPLGHQPGDSSREDAALAMAEMQNGASLTDLSTPTECPPPWPTGNSLDGMLGMAPMDLFDNIWAVPTEPLIWWNSGERFYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMF6</accession>
    <name>A0A367LMF6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PITH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_3413</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMF6"/>
    <dbReference type="STRING" id="1330021.A0A367LMF6"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="PITH" evidence="4">
        <location>
            <begin position="126"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI15598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="35238" checksum="6B5255798BC98E3F" modified="2018-11-07" version="1">MSSLPTEVTSTEQFNSIISSSKIVVAYFFEESFAPCRMLFPVFESLSRSLSRPKAVTFIKIDSTKYENLVKDYGVMEVPNFLLFRDAAVIDKAHAANPQGLQDLVKNLASQVDSLGENEASIASWRGAEIVRGSHDITDQVEVRGCELLNSHQVAGLVDVLFDPSKPSALGEEHTSTKDWVQSGADDQLLLFIPFQSSIKLHTLQITSLPPKDQTEVSRPEVIQLYINRPRNMDFSEADDTEPTQTITLNADEWNSNGTINVGLRYVKFQKTNTLVVYVQKGVDGAESVRLDRVKIIGDEGLKREMGTLQKFGDGGSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LML8</accession>
    <name>A0A367LML8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Wax synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_3441</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the wax synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LML8"/>
    <dbReference type="STRING" id="1330021.A0A367LML8"/>
    <dbReference type="OrthoDB" id="2796277at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044851">
        <property type="entry name" value="Wax_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL O-FATTY-ACYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31595:SF67">
        <property type="entry name" value="WAX SYNTHASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="282"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Wax synthase" evidence="8">
        <location>
            <begin position="333"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI15684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="523" mass="59073" checksum="04F0D5345312EF7C" modified="2018-11-07" version="1">MPSTDTIVYFVSLSLAVAAASLTIDVVVDQVRAAYHDAFARAVAGGRSLPLLIPYSLLGTFIVPTLWLSVPHVRWPAFYHTRWLVVGFSIAFNVHIARNSSCTNIAISYVTGLIAAWGILTTLHLLVWSRPQFDAARAVRSSASSDPALVKNPKVTRPPNKDAFHWQPFPADAPFLDRLGWAADLVMSFRGIGWNWSITSVPRPRMPCRVRPNDPVDFEPMSRTSRSGAEICLTEGEFVRKRIFTIAMVWLITDFCSILVIRDPYFLLGPDHAHELPPHLRAIPAGLLLAYREFLVITSLLCILCGIFSLNDLAQYWLLKAWCPSRSGLWLHPTYFGGFSSVLDRGLSGFWGGFWHQTFRHQFLAPVTWAIETGYIKSGSQVAIISGTFISFLQSGFLHSFGSLSSIPETKTWRPVIFFLLQAVGMYLQDTLRIQIRRFVPKPHIAIARTANFLFTLGWLYCTAIFFIDDVTSAGFAFAEVLPVSPLRWLGFGRASDSWFRWDRDCFPKWHRGQHWWESGLAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMW3</accession>
    <name>A0A367LMW3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">V-type proton ATPase subunit E</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_2910</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase E subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMW3"/>
    <dbReference type="STRING" id="1330021.A0A367LMW3"/>
    <dbReference type="OrthoDB" id="10263003at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033178">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, catalytic domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2320.30">
        <property type="entry name" value="ATP synthase, E subunit, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00311">
        <property type="entry name" value="ATP_synth_E_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038495">
        <property type="entry name" value="ATPase_E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002842">
        <property type="entry name" value="ATPase_V1_Esu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45715">
        <property type="entry name" value="ATPASE H+-TRANSPORTING V1 SUBUNIT E1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01991">
        <property type="entry name" value="vATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160527">
        <property type="entry name" value="V-type ATPase subunit E-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI15740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="229" mass="25803" checksum="F619B96CC99DCAA8" modified="2018-11-07" version="1">MSQHALSDQQVDNELRKMTAFIKQEAMEKAREIEIKANEEFEIEKSKLVRQETDSIDSQYDKKFKQATMSQQITRSTVANKTRLKVLGARQELLDEIFESAEKQLADGTKDKAKYHKILVGLILEGLYALSEKQVMLRARKKDHDMVKKAADEAAKTYKKEIGSDVEVKINDENPLPENSAGGVIIVGGGGKIDINNTFEARLDLLKTSAAPAVRQSLFGKNPNRKFYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMY0</accession>
    <name>A0A367LMY0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoglycerate mutase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_2562</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMY0"/>
    <dbReference type="STRING" id="1330021.A0A367LMY0"/>
    <dbReference type="OrthoDB" id="9895617at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022234">
        <property type="entry name" value="DUF3759"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37450">
        <property type="entry name" value="CIPC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37450:SF1">
        <property type="entry name" value="CIPC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12585">
        <property type="entry name" value="DUF3759"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI15796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="102" mass="11230" checksum="23AD5E0D61F6AEDA" modified="2018-11-07" version="1">MDDSQQARAYQEVTQGSHEAKFSHELLGGAAAYEAAKAYEDHVSRNGQPDNHAKAKEILAGVIGAFVDREVETKGLDYIDSEKAKRHAQVQAEQQLDNDGQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LND0</accession>
    <name>A0A367LND0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA endonuclease activator Ctp1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_1956</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LND0"/>
    <dbReference type="STRING" id="1330021.A0A367LND0"/>
    <dbReference type="OrthoDB" id="5801062at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010792">
        <property type="term" value="P:DNA double-strand break processing involved in repair via single-strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013882">
        <property type="entry name" value="Ctp1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033316">
        <property type="entry name" value="RBBP8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15107:SF0">
        <property type="entry name" value="DNA ENDONUCLEASE ACTIVATOR CTP1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15107">
        <property type="entry name" value="RETINOBLASTOMA BINDING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08573">
        <property type="entry name" value="SAE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA endonuclease activator Ctp1 C-terminal" evidence="5">
        <location>
            <begin position="495"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="136"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="303"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="317"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="331"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="395"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI15945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="643" mass="71381" checksum="13B3BC12C12C5EE8" modified="2018-11-07" version="1">MAAAADRDVRQALHTALDQMCDQLGRELVAERETNSRFLHRLLQLVKDGEPIESVLQQHLRRETEPIDAPLEAVASLKTDLCNLRRRFNALSANFNTAKNALQERTRSRDGWIRHASHLERLIADAEKKHGIKIIFPKGRSPAAAATPRQYSPAPGARPDDSRDANSEQRAAADVPLGFTQGDSDEEQQLPPMPNHQPCDSEPRQPASEPSSDIPVVISERSVRKKRRNDSAPAAVKPRVKMEPSENSSPPSAIRFAARSDSDTQRSLDLGDIAKKIETPRKRKRMADLDSRYISIASDHFVPSVTRSTAASTPIEPPRRATDTRKESALTPLSVNVRAQRSGQSDSKVRPLKRGVAHAISALAEDGDSHGAHPHASRNQDAASITPLAKGRLSTLPNSTSSAPDDTVLSRSADPRSLPIPQRRELPFEKTPNAQASKPSRPKKERTGPSPETAPTRDRPLRQGKASSLRNKPLSELQLEDFKINPQANNGHDYAFTEVVRDKAERSCLPGCTDMHCCGKQFTALARSQRPDPPLTPAGRMEEQKLLEDYLGDAAYRLASMSGPERAELWVEAKAQELANRYGKHRHRFSRMQSPPGFWNADFPSTQELALDRVEAAKRERLAVAERHREATRPGGRWLFRDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNU2</accession>
    <name>A0A367LNU2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoglycerate mutase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNU2"/>
    <dbReference type="STRING" id="1330021.A0A367LNU2"/>
    <dbReference type="OrthoDB" id="425925at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016604631" description="Phosphoglycerate mutase family protein" evidence="1">
        <location>
            <begin position="16"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="182" mass="20799" checksum="54FC252D43F80603" modified="2018-11-07" version="1">MRPLLFFLSFGVALAATKPTVYLIRHGEKPRNHDDPYLSPTGEKRAQCIRKVFGSGSGYNIGHVMAQKPRRNGHRRRPLDTVAPLAADLGLEVDTSCRKKDMDCVRDVVENYNGKGNILICWEHKRIKKIARELGGRHLDKYPRYAFDLIWVDPYPYDEITEVRSEHCPGLDDEGDDMSTML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPE3</accession>
    <name>A0A367LPE3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPE3"/>
    <dbReference type="STRING" id="1330021.A0A367LPE3"/>
    <dbReference type="OrthoDB" id="4525115at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="395" mass="42025" checksum="B934FCD75E56D7D6" modified="2018-11-07" version="1">MSSKNWNDRADKDLFFTILSVKNIGVISGAEWTTIGNHMRSLGYGFTNEGCRQHFQGLRRAQNKADTNGIVSETASRRVDPTLNPITRRPGPGRGRPRKQSSPVPADDAPVMSGSAPAPGSASVHVSVPVPVPVPVPVSFSGAIPGPYFGAVPAQVSPSVISPAMSHPRPSQEEPSTPTAEKAAAADVVPPPPSVPAATAAVATTTIDSPRPPMMPPDPTAPDVVGDEADLDAESTIPLADQMGSTDEPPLKRQKMEPQDADSEPLDEEAVLALAAHNGSTGPDPYGSEFLVDLVCALHEVAALSPAAKVAIEEFLRNEGHDTSWNAIRRQVMRWTPEVDQRILLAMFQHVTMTAGDWDNVMSELRGDGYNFSESALRSAASSVYPVVVRLFQPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPM6</accession>
    <name>A0A367LPM6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UNC-45/Cro1/She4 central domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPM6"/>
    <dbReference type="STRING" id="1330021.A0A367LPM6"/>
    <dbReference type="OrthoDB" id="26149at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040144">
        <property type="entry name" value="RAP1GDS1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10957">
        <property type="entry name" value="RAP1 GTPASE-GDP DISSOCIATION STIMULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="467"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="643" mass="69347" checksum="3AAC6FF46FF81DFD" modified="2018-11-07" version="1">MCLWFVPIHVYLTRKPVSWRRPFGHSGILDFSLDLLAEEEDENDDQASSLDLQLHCLRLVGNACADTDENRARVVRQDGLARIIRHLADDRLAPVAVPVLLNVLMDYDAAQQAASRSGLSRRLVTLMSSASPETPSALLSHVCRVLEMLVSQDGEPEVASPSTVDVLLRLASTLPVEIDDDDDDDDDIVFSLLELAVAYLANQAFQTSLISGPSMSLFIQAFRRMHSLPIAEDPEQAARLKRLSSSLLTTLSELSSNDSFPAHHPPPSPVHQTLLSWIRHPDAPGLQSAACLALGNLSRSDEASVGLVERDAIHLSLIHLLSDPAVGDPQLLHLALSFCRNLAIPLPNKTTLSPLLDPSCVPRILGLDSLPQLQLPAVSVVRLLLLNCQPNVRRLCSSDDSVSAIISLFHRSDAEPTKAEAARCVVALCRALHTSPTAPSQILGSPSALTQAEDTSTSPTSPPSKSSPPTTTTTTNPDDGAQQRSLFYEKHDPSRPLSFLLPQRKWPALRSEAWFVLALMSRSPDGAKVVNAALDPQPATDALVEAITGRPPPPHGEASSPSHEDHHATSSSVIASDLQLGPQQANRPEQPASVAKADRENALVLVTGLLSHGKGGIPEPRLALLRRLVNQGAELVATQRTQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPZ5</accession>
    <name>A0A367LPZ5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cyclin-dependent kinase 1</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">L249_2667</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Plays a key role in the control of the eukaryotic cell cycle. Required for entry into S-phase and mitosis. Acts as a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II. May function in concert with npp-16 to arrest prophase blastomeres in response to anoxia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin. Interacts with cks-1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPZ5"/>
    <dbReference type="STRING" id="1330021.A0A367LPZ5"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07835">
        <property type="entry name" value="STKc_CDK1_CdkB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000706">
        <property type="entry name" value="Cyclin-dependent kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000027">
        <property type="entry name" value="Putative Cyclin-dependent kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF254">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="4"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00065691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RCI16457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="333" mass="37519" checksum="0D773E3004D473D0" modified="2018-11-07" version="1">MDNYQKLEKVGEGTYGVVYKARDLANGGRIVALKKIRLEAEDEGVPSTAIREISLLKEMKDPNIVRLLNIVHADGHKLYLVFEFLDLDLKKYMEALPVEDGGRGKALPEGSSMHLMQLGLSNGVIQKFMMQLCEGIKYCHSHRVLHRDLKPQNLLIDKEGNLKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGGRQYSTGVDMWSVGCIFAEMSTRKPLFPGDSEIDEIFKIFRALGTPTEDLWPGVTSYPDFKSSFPKWQRDFGNALCQNLDDKGLDLLEMMLVYDPAGRISAKQACVHPYFEGYVAPPPPPPPQQQPTSGRLNGYYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQ11</accession>
    <name>A0A367LQ11_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_3270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQ11"/>
    <dbReference type="OrthoDB" id="3358048at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="54"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI16491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="195" mass="21384" checksum="2EFBFB4CDC4232AC" modified="2018-11-07" version="1">MPPQKARLRRPFHPPDSDSDSDSQPDALDEQEQEAVIFRLVEANAARNRLFLKILLALPLLASIPYITLLPSLLALLSLTSLFATAFLLHRLPPQETGIPLLDQWASLSRQRHPLAPSYKSPLETYLPSLNAVAAVLLVFMGFLSDRRAQGSLAWIGAGNLPAIVYLAVLLAKYVMAGVDPEGELSALKYNYKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQ54</accession>
    <name>A0A367LQ54_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UmuC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_2413</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQ54"/>
    <dbReference type="STRING" id="1330021.A0A367LQ54"/>
    <dbReference type="OrthoDB" id="447129at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1170.60:FF:000006">
        <property type="entry name" value="DNA polymerase iota"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46404">
        <property type="entry name" value="DNA POLYMERASE IOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46404:SF1">
        <property type="entry name" value="DNA POLYMERASE IOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UmuC" evidence="3">
        <location>
            <begin position="18"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI16517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="538" mass="60157" checksum="BC49442F3E364C02" modified="2018-11-07" version="1">MQEPSRPSAPQRKDDRVLLHFDYDCFYAQVVENKDPSLRCRPLGIRQKNILATCNYHARRRGVRKLMLVSEAVVICPDLVLVSGEDLTPFRQTSKRLYDFFRSHSWNNKVERLGLDEVFMDITDMVDYNLSCLNRLTLADSFFCLSMKDPEQGFGCDLTSVAGCVAGPPVLSGQLHDDRYLRLLLASHLASYLRLKVETDFGYTSACGIATNKLLSKLVGSCNKPRNQTTLLAWTENAVYSFIDGYGIKQLPGIGRKMVLSIESQIHSQDPEVKLPLTVSQVRSHPSTSASSLETLFRGPGAEKGVGARVWRLIHGADPTEVKEATDVPAQISVEDTYKGLETVAQINEQLYALSCSLVRRMRCELIICEEEETTWLARPKTLRLSVRSWPAGPSDNFSRISRSGPLPGFVFDSEADVEDIAQQLTTQALIPLLRRLQSDSGQRWNVQLVNICVANMVDERTGAERDIAAMFKTQDEVLRPWRAMREPGDEGVGEAAFEEADLDGGWDSTLHSSCPRCGHLVPGFAMAAHARYHELEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQA0</accession>
    <name>A0A367LQA0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQA0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="375" mass="41982" checksum="4ADB084751BEB77C" modified="2018-11-07" version="1">MEVKVVVNKVVVPYGNLLSELSSTWYELRFLHERARLSFSNEPRLLHDRTTSATFFLCWLSDLTSRPCLSLSRGSDIPVPEAELISGSSQSPNGKTGIHTHTHPLMAKAMIICLGSGDQGGADEVEVLHCNMYCYMYDIIDIVTKFQELHVHAGLCDGLNLSAVYAEENRCLRWKINPSIVVLALFLKKTPLVISPLSVELHGSDGLTPSVGQDVTLRKRWACGETETVLTGGHQLPVPSALHFPVTFCLKCSLESSFQRKKEARRAVNQNLTTSSLSLTGGSINSHHAYIRIGQTTAPARNSMNEYIDFYERQFRKRKESHSIRWGTESLQGEDEDEDEDEGVRMRRHPPPPPLGPHLTSNRLCPTRDFSLSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQI5</accession>
    <name>A0A367LQI5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fungal lipase-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_1924</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. Lipase family. Class 3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQI5"/>
    <dbReference type="STRING" id="1330021.A0A367LQI5"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051218">
        <property type="entry name" value="Sec_MonoDiacylglyc_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856:SF11">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016603192" description="Fungal lipase-type domain-containing protein" evidence="4">
        <location>
            <begin position="22"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="5">
        <location>
            <begin position="105"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="5">
        <location>
            <begin position="430"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00043996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI16715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="637" mass="69548" checksum="9F8C86CB72F01E90" modified="2018-11-07" version="1">MQLLTALQVLLAALQMGICNGQQKTLPAEKITAEQLHLFSKYAHRAYCGQIYGQPLDSSLCAEGPDPAKSKCKGLGKAVIVRRFKYESGNVPGYMAVDADKKLIVVAFRGTDIKSWANIKVDLSKVEVPSIFHNRELCRDCWLHSGFASAFDDMSAAVEDGLGKELDKMGPEGVRVVVTGHSLGGAIATIAGSYLRTRFPKRSIDIYTFGSPRVGNQAFAKFVMEQKNGVTVRVTKKKDFVTSVFHHIPPFLDYTHVYPEVWLKEGLKTVAAFENPYQDAPVTQCNERRCGSDSCGLSFIDSNFIFTCTKVDHSNYAGNFPCGDEDGDEDGRDETDGEELQQIVGDIQSAVNKVLARQFLLFAAHAVQPAYEGSERLCDVLRQSRRPYVPGLCTVRVTLMTHATTMTAAEPENLLILSFHEPERKTRLTKAQRDFSLVCRGCRVNGDFLQALEAIIPPPSQTAAASSSSSSSSHHLLWAVDQLKAKYASERKPVHRVVFTGYCGGGAMATLAAAYGRMKGFPIDLYTYGSPRVGNEAFANFVTNYDRAVSARITGGGHEVVLRPDKTDGYSHYGPEFYFPQGLVEADQGKNLRICGGVEAKGCSVDPPLMGASAVGGRLVYPSKEVFCSSFDPSTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQK4</accession>
    <name>A0A367LQK4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">magnesium chelatase</fullName>
            <ecNumber evidence="1">6.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_2002</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.6.1.1" evidence="1"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQK4"/>
    <dbReference type="OrthoDB" id="5582146at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016851">
        <property type="term" value="F:magnesium chelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.80">
        <property type="entry name" value="Magnesium chelatase subunit I, C-Terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041628">
        <property type="entry name" value="ChlI/MoxR_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052041">
        <property type="entry name" value="Nucleic_acid_metab_PIN/TRAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11603">
        <property type="entry name" value="AAA FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11603:SF132">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17863">
        <property type="entry name" value="AAA_lid_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ChlI/MoxR AAA lid" evidence="4">
        <location>
            <begin position="302"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="81"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="81"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="95"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI16691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="396" mass="42606" checksum="B6FD37CB9C42EDFA" modified="2018-11-07" version="1">MAAHDDLSDLELALLLCLVSREHGLLSSPTHACGLLVRELQLAALKTFGLRCVVVDCHPDMTLESFASALLCPPSKPIAPTAVPGPSSSSSSRPTPTPPPPPPPPPDPPPADSLRPTPPPLDTSASAFRPPPDSLYQSDAQRHSWRAGSPPISPEPGMQIANCVLARDLDRAPIAVQIQALELLRTRRIFTRTSVKAAPRQFVFLPVIQAAFAGEAHVTPHLNDFLAVAHWHDPDLGFANLDDLDHDANGGPSAISVDVLAFAPAPPLISEADINRLAQSSQQVEVDIDVLRYQMNIITFLRMHRAVAQGMTPAATKMMEKITRCLASIHNIDFVTPALVALAINKVYLHRIRLVAPDRERSLQWGSSLEAVEAVLAGVGPEQIIQDVLDTVTAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQL8</accession>
    <name>A0A367LQL8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_2572</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQL8"/>
    <dbReference type="STRING" id="1330021.A0A367LQL8"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF3">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11970)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1996" evidence="3">
        <location>
            <begin position="40"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="378"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI16640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="59378" checksum="B17800A6426C09BC" modified="2018-11-07" version="1">MKLDNLRSVGLVHAALAQTPAVLGHIFTVNCKPLTIQRADPILFPGLISPHVHSVVGGTAFALAETNEQARAANATTCDKTLDNSNYWQPQLYHQRLDGRFELVEMQGIAAYYIDRACDYVPGRQNCNDAPHGRAPPAGLRMIVGNPHLRTYDASNPEQRAISHICLGSGFSHDTPHLPSERCERLRAETYFPSCWDGISLDSPNHKSHMAFPSIGDYNTGVCPPSHPKAILSVFLEFFYDTAAVKNFNRWVWAMGDPTGYGLHGDFINGWTDQQALERAMDTCTGPLGVDDARCSLNVGPNGPGQPSPRWPEVEPPKEEVGLGGPLERLPGDNPVTGAAEGGGKPATYGFCVLHETTTTQQASHLVTHSLASELPPFTALSYVWGDSADTVTASWSGNTVSMTRNLSAILQCLTSSSASEPMLLVWIDALCINQADLGERAEQSQAHGPDLLPRGSLDVLSHVCQYPSTRGQLSALPSWVPDWTATVDETFHHYYSERTRRMALSDGSMGLEAEWQRLGDGRVSTKAMIIGHIKTTALGIPDFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQX2</accession>
    <name>A0A367LQX2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_1886</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQX2"/>
    <dbReference type="STRING" id="1330021.A0A367LQX2"/>
    <dbReference type="OrthoDB" id="294730at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000039">
        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF20">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="163"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="252"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="443"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="473"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="515"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="131"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="78"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI16853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="562" mass="61138" checksum="21F454AD1E95748A" modified="2018-11-07" version="1">MDKQTTAPEKPLGPGPPSQHITAGRASCSSSTSSRLPPPPSPPRRGRRRARIGACVLGGAGVTIGPRITSLPEWLKDEAAATGPGGGGGGRVGGLSSDDDVVGDGEEADSSNAIVNRQLASETGRSIQYRTCSWQKTAALLFSEYICLAIMSFPWSYSFLGLVPGLILTIVIAAVVLYTSLVLWELCLRHPEVRDVCDLGQMLFWGKPWAWWATAIMFVLNNTFIQGLHVLVGAEYLNTMTESRDIPGCRTVQFSLAVTIICWLASLPRTFSMLSKLGTGAALFTFVAVILATVFAAVQPQPAGYDPAKGMPRWTALPVHSTTFVQGMAAFLNISYTFIGQITLPSFIAEMRDPREFPKSLWACTVAEIITFSIVGAVIYVYTGNQYVKAPAFGSLEDLYKKVSFTFMIPTIIFLGCLYASVTARFVFFRVFRGSRHLNDHTVVGWGSWGGILLCTWILAFLISQLIPFFSSLLSVMSSLFDSWFGFIFWGVAYFRMRNADLAAGFRRRPVSDMLSMALNVTIILTGFFFLTVGTYASVQGIVDAFRAGEVGGVFSCKSNGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRQ7</accession>
    <name>A0A367LRQ7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1802</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRQ7"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI17098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="116" mass="13310" checksum="CBC6A83D03B4F8D7" modified="2018-11-07" version="1">MAVVGGDGAIVGDSERAMFYHLVVDAFDRMEKHDQTDAVYDLYPSSLSLSRRKTGRRERQGFPGPPGHRSAERESEPELGRELEEARREDQGLFWEEWWSRLIVEDGRGGVVFLDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRX9</accession>
    <name>A0A367LRX9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_2388</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the SNAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRX9"/>
    <dbReference type="STRING" id="1330021.A0A367LRX9"/>
    <dbReference type="OrthoDB" id="9984275at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005483">
        <property type="term" value="F:soluble NSF attachment protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15832">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000049">
        <property type="entry name" value="Alpha-soluble NSF attachment protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000744">
        <property type="entry name" value="NSF_attach"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768:SF8">
        <property type="entry name" value="ALPHA-SOLUBLE NSF ATTACHMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768">
        <property type="entry name" value="SOLUBLE NSF ATTACHMENT PROTEIN SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14938">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00448">
        <property type="entry name" value="NSFATTACHMNT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="166"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI17206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="300" mass="33680" checksum="4E73313CE3FF99E1" modified="2018-11-07" version="1">MAQDPRALLQKARHRPRLVAEKDLQSAGKGLSFFGGREDKYQNAADLFIQAANAFKMQKQNLEAGKAFEKAAQVQSSKLNEPDDAANTLVDAYKAYRKEDPQAATRCIDVAIDRYCAKGNFRRAASHKENLGELYEQDLGDTKAALECYEAAAGWYDGDGAAALANKLWLKVADVAALEGDYHRAIENYEKVAEVSINNNLMKYSVKDYLLRAGICHLASGDRVGAQRALERYRDMDPAFATQRESMLLTDLCEAIEAKSQEQFTDKLFQYDQICKLDKWKTTILVRVKNAIEEPEEEFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRY3</accession>
    <name>A0A367LRY3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ca2+-modulated nonselective cation channel polycystin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRY3"/>
    <dbReference type="STRING" id="1330021.A0A367LRY3"/>
    <dbReference type="OrthoDB" id="5377012at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI17171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="436" mass="44515" checksum="C989C6B273EC44E2" modified="2018-11-07" version="1">MAMADGADEPHDRQANRRRPFATWVKKLTNFKSSSDGDRPKRHMRMRRGAKLNNPYPQSGHVSANHNQNHNNKNSSPDKDAPSAPSLVAAPTRSPVSSNDVVPPSADGQAPPTAGAQSMAGTASTENEGQRSIMTPSHGASSLAGTNRTVGGGIDSRRGGDSTFSSPAPSVRSLTTTLTTIQSMPPNANGSNSYNINNAQSIQFSQPFPTTTSPASAIPAHLAPTGHPTTYTAATANNMLTDNASILTLASSSKRRRRRSMDTDASVRALAPSSLWGGSRESLPLSVLSANIESAGMPTTPGLHGGGPRLGAERNSLYSTAGAGPTLASERNSLYAKQGDGASIRSGLLGHGRPDSVSGSAVAVTSPLASPRGASDEKRALAPTTTAITTTAAPVATAAAAATTATTASTTTTTTSGGATTTEDKAVGRTPAAQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LS14</accession>
    <name>A0A367LS14_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_2389</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LS14"/>
    <dbReference type="STRING" id="1330021.A0A367LS14"/>
    <dbReference type="OrthoDB" id="10250284at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22386">
        <property type="entry name" value="KH-I_KHDC4_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000037">
        <property type="entry name" value="KH domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047889">
        <property type="entry name" value="KHDC4_KH-I_second"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056149">
        <property type="entry name" value="PRP5/DDX46/KHDC4_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031121">
        <property type="entry name" value="RIK/BLOM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055427">
        <property type="entry name" value="TRAPPC13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15744">
        <property type="entry name" value="BLOM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15744:SF0">
        <property type="entry name" value="KH HOMOLOGY DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23469">
        <property type="entry name" value="KH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06159">
        <property type="entry name" value="TRAPPC13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="275"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="88"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="366"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="468"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="780"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="870"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="366"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="476"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="784"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="877"/>
            <end position="895"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI17208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="936" mass="102276" checksum="0961F33A2A906C1B" modified="2018-11-07" version="1">MADDDDRHGGRRSRFDQTESEPRRPSRFDRRSRSPPPRRPEARDRSPLARDSNSESTKSPIDPAAAAAAAAARINAQLQARKGVQHVDVPPINKPDQNQTPSAPARSATSSGGLAPPRKTDGEMYVSDGDYIKDIEVNDLRNRYVLTKSSTQKMVIILDAPLILQTHSSPGTCCCCLTTSTTCLRSTQLIKEQTGADITTRGSYYPNKNMATAANPPLHLHVTSTTKEGLEAAVAKIQEYMQQELPQLVDERRFRRRDQEQPHVERDEYGRRKWPEEKVFVGLEPVPGFNLRAQIVGSGGSYVKHIQSETGCRVQIKGRGSGFLEIATNRECDEEMFLHITGPDPRMVEKGKELCEDLVANVREQYEEFKSRPPRHGDRGGYGDHRGGRSHDQSYSYGRPASDHQVQASGHTADGGGANSASAVDWSQYAAQYYGNGQDPYAAYGGYQNYVAWYQYYYQQGQGAVGQAVPGQSAAAPPPPTEAAPPPPPSDAPPPPPSSASPPAPQAPHSSAGAFNAVRYLSCPVTAHKAYPDSRSHLPLASEPLAQRNLSDERHLRMSHQRYPSHEAIKEPHSVSVKVLRQAGSFPTGNGCETSVGADNVDDRLSRPSLVTQYPIDQPLAASPKPARASLACRTGAEVTRAPFVLSRMLKLPASFGSAYVGETFSCTLCANNELSDGSDKKICEVRISAEMKTPGQATAQELQLMPDAEEGGRDVDGGGTVQRVLSFDLKEEGNHVLAVTVSYYEATETSGRTRTFRKLYQFICKPSLIVRTKVGKLLQQEGGNDDDDDDDDDNNDEKGGRATSRGGRRWVLEAQLENCSDATVQLDKVVMELEPGFTYADCNWEASEKPLLQPGGVEQACFIISEVEEGGRAGGGEEEEEEEEEEEEEEEEENGAEKKPARLLQGRVTFGTLGIGWKGQMGNRGFLSTGKLGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KYW9</accession>
    <name>A0A367KYW9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS10m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">37S ribosomal protein S10, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Mitochondrial ribosomal small subunit protein 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_3345</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000033">
        <property type="protein sequence ID" value="RCI07369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KYW9"/>
    <dbReference type="STRING" id="1330021.A0A367KYW9"/>
    <dbReference type="OrthoDB" id="366214at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.600:FF:000003">
        <property type="entry name" value="30S ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_uS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="7">
        <location>
            <begin position="52"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00078476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI07369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="205" mass="23718" checksum="89B17C4070DCE889" modified="2018-11-07" version="1">MGSRGKGNVWKRLSSTARAVVMSPYPRRSRSLQALYLKPLKREACYGIPSCDLQLRSFSLQPLDFFADFALRAAYYLGLPAYGPIPLPRITERWTVPSSHFIFKKAQENFERVTLRRLIQIKDGNTEMVQLWLAYLQKRQYYGVGMKANVWDFSSLGAGSEAREHGDHMNYSWSRLTQTSIMRKVGDVEQLLNNRRLERITSFSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L033</accession>
    <name>A0A367L033_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mechanosensitive ion channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_5689</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000024">
        <property type="protein sequence ID" value="RCI07803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L033"/>
    <dbReference type="STRING" id="1330021.A0A367L033"/>
    <dbReference type="OrthoDB" id="544685at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016688">
        <property type="entry name" value="MscS-like_plants/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_beta-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058650">
        <property type="entry name" value="Msy1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323:SF15">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25886">
        <property type="entry name" value="Msy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017209">
        <property type="entry name" value="Memb_At2g17000_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="247"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="467"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="411"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="703"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="703"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="777"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="813"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI07803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="830" mass="92544" checksum="37696520F9622C35" modified="2018-11-07" version="1">MTDPKPDRPQFSCGESIERPPSLSRHTTTSTGTVDYFPDIGSRLPPSGQRMHGTRAADDLEILRVQRSVTGDVPLKEEPYAEPEPEPEDETVDGEDTKRERKDNALFRLRAMIHSLPRFLRYLVYLIPGGCLLLIPVLLGYFQTNPDERLLGGVGGVELMWFGIWLEITWCSLWLSRLLMNILPPLFFGCAWIMGSPNTKQWKEFGRRLEVPAAVFLWFLSILISFKNTLDGHHASPPPDSGDDDPGIRWVDVVNKVIIALFILATLNFLEKIVIQWIATSFHRRTYSTRIENNKADVRQLAKLYEYAKIKLNQGHDRLHKGGPGVGGSATTLQTLHENARQVIGKVGQVAGKVGNDLIGRKVNIDATLKVVTQLLRSTPKSYTLARFIFRSLVRSDRETVYADDLKAVFQTKEEVDAAFNVFDKDLNGDISLGEFEAVCNEIHLETKAIAASLKDLDSVIHKLDRVFLFIIVIIAAAVFVVILSGSAAAGLASIGSTVLGLAWMLQATAQEFLQSIIFVFIKHPFDVGDRVTVYGSTGAKMKGDEYYVTEISLLYTEFKKMQGHIVQAPNSILNTLFILNHRRSNGTSDPVLLEMRFGTPVEQINELKRRMVDFCLRHKRDYHPTVVTEMLHLDEVKSCSMNLVVKHKGNFQSESLRQSRHNKLVTEIMHQMILIGIEGPSHVEPGGSPQYPIYWAGVAPPPPPPSPPPPPHPPHPPRPAATPLGGEGPSMLRSGASLRVPELSDDGVEDVFENRRERTMAQRIASIRKKERGLRSAAESGSAEASSSVARSASRVSTHQHQGSRERRPTFLQRSLTMVSAKNSREPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0I9</accession>
    <name>A0A367L0I9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein PNG1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein png1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_7800</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transglutaminase-like superfamily. PNGase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000022">
        <property type="protein sequence ID" value="RCI07953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0I9"/>
    <dbReference type="STRING" id="1330021.A0A367L0I9"/>
    <dbReference type="OrthoDB" id="409136at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.620.30:FF:000004">
        <property type="entry name" value="Peptidase (PNG1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000011">
        <property type="entry name" value="peptide-N(4)-(N-acetyl-beta- glucosaminyl)asparagine amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.620.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002931">
        <property type="entry name" value="Transglutaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF19">
        <property type="entry name" value="PEPTIDE-N(4)-(N-ACETYL-BETA-GLUCOSAMINYL)ASPARAGINE AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01841">
        <property type="entry name" value="Transglut_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00460">
        <property type="entry name" value="TGc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Transglutaminase-like" evidence="7">
        <location>
            <begin position="242"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="36"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="400"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="402"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="442"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00071430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00071953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI07953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="451" mass="50796" checksum="C7A9B74807A778F9" modified="2018-11-07" version="1">MAGRATPSSSSSHGEEWAHDLRIRFEGLLRDKRMTDLRSSPRQLSPGPGLTNRASSANLCGHASVGHRRPATSHGQPTPPSYSCLRHLPKIPTPPAAGDRDSQKFRNLLISLSLTPTKYENPGLLDEALQTIPLDRIYSEAEEESQVLQAEAESMGDGRRPEWGYQDCVIRALLRWFKRSFFTWVNNPPCSICLSPTFANGMTAPTPEESACGALRVELYRCSAHSCGALERFPRYGDVWRLLQTRRGRVGEWANCFSMLCRAVGGRVRWVWNAEDHVWTEVYSEHRQRWVHVDACEEAWDNPRLYSEGWGKKMSYCIAFSIDGATDVTRRYVRRSEYANERSGCPEEVLLYVMQEIRSLRRANLRKEERFRLEKEDRREDQELRGYVVASIAQAVTDLVPGSSSARSPGSVTGQDVKLPAEQPGRQSGSAEWLPAQGGRQPQPPREPGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0Q5</accession>
    <name>A0A367L0Q5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000022">
        <property type="protein sequence ID" value="RCI08008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0Q5"/>
    <dbReference type="OrthoDB" id="4106209at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="353" mass="39360" checksum="B1CDE1FF54E94EAE" modified="2018-11-07" version="1">MKGRPIEELVYECMFQRPKSTDPQNFNALLQRSLIPEVRQETHAFYGHLDTQEAKYPGLDYTHETHRIRLSRWPWHRRLFRAFNALVLTHAEIAALTKWEGTKWAKEKFEKEQGVVIRDTTADGFPTWNESVELRRHVPSLTADGPSPGHGDGNNNNDNGDEGEDSDDALESVGLELNQRLRAQAARREAGETTAVLDEEWEQWLKYAIETGELTMVTEQMTEQMFRRANSSSAVIPAALIPQNMLRAARAGQWSEIPEILQPVIRRTLDAEFAGRGQPPRPPAPSGSAYPRRQTIDDSMRMRAAWPRRTYSDLRLPVGEAASAAAAAAAAAATATPAAATVAVPRTAQARGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0X9</accession>
    <name>A0A367L0X9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_6210</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus</location>
            <location evidence="6">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAPP small subunits family. BET5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0X9"/>
    <dbReference type="STRING" id="1330021.A0A367L0X9"/>
    <dbReference type="OrthoDB" id="3364529at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14855">
        <property type="entry name" value="TRAPPC1_MUM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.70:FF:000013">
        <property type="entry name" value="TRAPP complex subunit, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF16">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4 6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI08076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="161" mass="18133" checksum="AC98622BDAE3B6BA" modified="2018-11-07" version="1">MVVYSFYIFDRHTECIYAKSWLPPSPSSTTTTTTTTTTTTTSTTRSKPATTASDDAKLVFGTVFSLRNMVRKLGGEDDAFISYRTAQYKLHFYETPANLRLVLLTDTASTSMRNVLHQIYINLWVEYVVKNPLSPVEHKGGDGVKNELFDLGVDQFIRGLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0Y0</accession>
    <name>A0A367L0Y0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0Y0"/>
    <dbReference type="OrthoDB" id="4919936at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016562077" evidence="1">
        <location>
            <begin position="21"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="113" mass="12781" checksum="D8AC3982814CEAB3" modified="2018-11-07" version="1">MMKFAAVFITVAAAFSPLDNMEICKPGFQYCGGTLRNMGSSDKFYMPIKKALKTFEQDPSDELIDKTIFYCDGVLPRKVLFMLTCGNDRECSDSHGGWFRKEAKCVPKQSKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L197</accession>
    <name>A0A367L197_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_6361</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L197"/>
    <dbReference type="STRING" id="1330021.A0A367L197"/>
    <dbReference type="OrthoDB" id="1875751at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12577">
        <property type="entry name" value="RRM1_Hrp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12330">
        <property type="entry name" value="RRM2_Hrp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000466">
        <property type="entry name" value="Heterogeneous nuclear ribonucleoprotein HRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000025">
        <property type="entry name" value="RNA-binding protein Musashi homolog 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034156">
        <property type="entry name" value="Hrp1_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032:SF6">
        <property type="entry name" value="RNA-BINDING (RRM_RBD_RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032">
        <property type="entry name" value="RNA-BINDING PROTEIN MUSASHI HOMOLOG RBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="118"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="202"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="271"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="300"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI08210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="349" mass="38748" checksum="6A3A7A22DC1DE1F1" modified="2018-11-07" version="1">MTEPENFEEDLFADLYDDNEASRSAPGPGVATQQTDDQEPKIDDADAMVEEPSRIAEEEQGNLDAAEADGDGDDDDDDDVDFNLGGGSNGAAPVVQHQDAPATPPYGTVHRASAKEDGKMFIGGLNWETTDDSLREYFSQFGDVVECTVMRDSGTGRSRGFGFLTFKDARTVNIVMVKEHFLDGKIIDPKRAIPRDEQEKTSKIFVGGVSQETTDQEFRDYFAQFGRVVDATLMMDKDTGRPRGFGFVTFESEAGVEACINVPLEIHGKPVEVKKAQPRGNLREDDESSKRHKFRKGDDQSGQGQQMGNNGMTPQVMAQYFQRMQQYFAMMQSQMAMNRGMHMNPAMLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1Z7</accession>
    <name>A0A367L1Z7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 18">3-isopropylmalate dehydratase</fullName>
            <ecNumber evidence="6 18">4.2.1.33</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16 18">Alpha-IPM isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17 18">Isopropylmalate isomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">L249_8919</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 18">Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate</text>
            <dbReference type="Rhea" id="RHEA:32287"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:35121"/>
            <dbReference type="EC" id="4.2.1.33"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 18">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 18">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.33" evidence="6 18"/>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1Z7"/>
    <dbReference type="STRING" id="1330021.A0A367L1Z7"/>
    <dbReference type="OrthoDB" id="2279155at2759"/>
    <dbReference type="UniPathway" id="UPA00048">
        <property type="reaction ID" value="UER00071"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009316">
        <property type="term" value="C:3-isopropylmalate dehydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003861">
        <property type="term" value="F:3-isopropylmalate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
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        <property type="entry name" value="3-isopropylmalate dehydratase large subunit"/>
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        <property type="entry name" value="3-isopropylmalate dehydratase large subunit"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="3-IsopropMal_deHydase_lsu"/>
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        <property type="entry name" value="3-IsopropMal_deHydase_ssu"/>
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        <property type="entry name" value="3-IsopropMal_deHydtase_ssu/lsu"/>
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        <property type="entry name" value="leuC"/>
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        <property type="entry name" value="PRK01641.1"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="3-ISOPROPYLMALATE DEHYDRATASE"/>
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        <property type="entry name" value="ACONITASE"/>
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        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="LeuD/IlvD-like"/>
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        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10 18" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8 18" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="14 18" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="20">
        <location>
            <begin position="13"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="21">
        <location>
            <begin position="548"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="482"/>
            <end position="545"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="760"/>
            <end position="788"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="482"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="503"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="779"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000491"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002695"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
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    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00014371"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00031631"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00033368"/>
        </source>
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        <source>
            <dbReference type="PIRNR" id="PIRNR001418"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RCI08427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="788" mass="84967" checksum="1F0804422DAE34CE" modified="2018-11-07" version="1">MPVSDRNPQTLYDKVLSHHIVDEKLDGTILLYIDRHLVHEVTSPQAFEGLRNAGRQVRRPDCTLATTDHNVPTTSRKGLKDIASFIEEDDSRTQCVTLEENVKDFGITYFGLGDKRQGIVHVIGPEQGFTLPGTTVVCGDSHTSTHGAFGALAFGIGTSEVEHVLATQCLITKRSKNMRIQVDGELMPGVGSKDVVLHAIGKIGTAGGTGAVIEFCGSVIRSLSMEARMSICNMSIEGGARAGMVAPDDTTFEYLRGRPLAPRYGSPEWDAAVAFWRSLRSDADARYDIDVFIDAKDIVPTVTWGTSPEDVVPITGRVPDPETFASEGKRVAGRRMLEYMGLEAGTPMRDIVVDKVFIGSCTNSRIEDLRAAAAVVGGRRIAPNIKRAMVVPGSGLVKRQAEGEGLHQVFIDAGFEWREAGCSMCLGMNPDILSPQERCASTSNRNFEGRQGAGGRTHLMSPVMAAAAAIVGKLADVRELTSGGETKKSTTTTDWPGQINETGSEDEGGDNNNDDDDKADRLDDQPADSQPHTNTSVSSSSSSSAGLPKFLTVKGIAAALDMVNVDTDAIIPKQFLKTIKRTGLGTALFHGLRYEPSDGSEKPDFVLNRDPWRASRILVCTGANFGCGSSREHAPWALLDFGIKCVMAPSFADIFHNNMYKNGMLPLVISSAADMEAVAAEARAGRALEVDLPAQVVRSTAGDVLCSFEVEDFRKHCLVNGLDDIGLTMQLEDKIAEFERERTRTAPWLDGTGYLRRKGGRGGGKLAAKAVPVPVTNRGEAKDEPLDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L204</accession>
    <name>A0A367L204_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,4 glucan phosphorylase</fullName>
            <ecNumber evidence="10">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_8882</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="10"/>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L204"/>
    <dbReference type="STRING" id="1330021.A0A367L204"/>
    <dbReference type="OrthoDB" id="9215500at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04300">
        <property type="entry name" value="GT35_Glycogen_Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000002">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000003">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011833">
        <property type="entry name" value="Glycg_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035090">
        <property type="entry name" value="Pyridoxal_P_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02093">
        <property type="entry name" value="P_ylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468:SF3">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE, LIVER FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00102">
        <property type="entry name" value="PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="8 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI08445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="880" mass="99554" checksum="EDE7364CEEE30693" modified="2018-11-07" version="1">MASASSDHHLPTRQRRPSTSAPVVDIQGAVGPAGISRPKHKRTFTGFGPGEIKTVQGVLLSVEFVMYRAAWHKNQMRSFKDEHGFEREVVRHVETTLARSLFNCDESAAYAATSLAFRDRLVIDWNKTQQRQTFRDAKRVYYLSLEFLMGRALDNAMLNVGQKDVAKAGLADLGFRIEDIIEQESDAALGNGGLGRLAACFLDSLASLNYPAWGYGLRYRYGIFKQEIIDGYQVEVPDYWLDFNPWEFPRHDVTVDVQFFGHVNKMTTDDGRKLSVWEGGEVVTAVAYDVPIPGYDTPTTNNLRLWSSKASRGEFDFQKFNSGDYESSVADQQRAETISAVLYPNDNLERGKELRLKQQYFWVAASLYDIVRRFKKSKRAWPEFPDQVAIQLNDTHPTLAIVELQRILVDIEGLEWDPAWKIVTSTFGYTNHTVLPEALEKWPVGLMQHLLPRHLEIIYDINLFFLQRVEKAFPSDPDMVTRMSIIEESQPKMVRMAHLAVVGSHKVNGVAELHSDLIKTTIFRDFVKLDGPDKFTNVTNGITPRRWLHQANPRLSELIASKCGGVGFLKDLTQLNRLEGFAKDAKFRREWAEIKYANKVRLAKLIKTSTGVTVNPASLFDVQVKRMHEYKRQQLNIFGVIDRYLKLKAMSAEERKRQQPRVSIFGGKAAPGYWMAKQIIHLINAVGTVVNQDGDVGDLLKAEMICPASDLSEHISTAGTEASGTSNMKFVLNGGLIIGTCDGANIEITREIGENNIFLFGNLAEDVEDLRDAHRQGSISIDPDLERVFGEMEAGRFGPADNFRGMIAAVRQHGDYYLVSDDFRSYIETQQLVDEAYRKQDEWVGKCIVSVARMGFFSSDRCINEYAEGIWNVEPLVVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2E3</accession>
    <name>A0A367L2E3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2E3"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="110" mass="12761" checksum="6E7153215EFF732D" modified="2018-11-07" version="1">MQCFVAMYERRQIMRTLLLFGLAVDAEEMVFDSDHRTPRNRPFSSRPSTSPLASRGSKYNVAWHQEAFSVGGKVDGLYLHTTFAPCHVISYVNNRRTMCYFRPPNFDIHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2I2</accession>
    <name>A0A367L2I2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_4793</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2I2"/>
    <dbReference type="STRING" id="1330021.A0A367L2I2"/>
    <dbReference type="OrthoDB" id="360390at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12296">
        <property type="entry name" value="RRM1_Prp24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034397">
        <property type="entry name" value="Prp24_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031766">
        <property type="entry name" value="RRM_occluded"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16842">
        <property type="entry name" value="RRM_occluded"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="578"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="655"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="746"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="864"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="531"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="822"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="947"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="792"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="840"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="990"/>
            <end position="1004"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI08643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1033" mass="115351" checksum="F360F96B3F891F69" modified="2018-11-07" version="1">MVNPVGEDSWIAYLEEAARNASDIEQCVHVVELYKRAIGAEPASIRLWLAYCQYFWSLWVRSQANDGLWPDHEQTMMARELFTFGAALDLWQQGYEAIKYRIDDSHLLWDRWLSLELEQLAKTKTPEGVRRVTHLYRDRLATAHLSWDDTSQAFSTFLSEYNTAAWEETMKEVTALSQGAKQALAARDAFELKLKEASSDDNLKSVMRGYLEWEIRQSQGKASNLCCGLFERALSSLFALDDGVWQEYIVFVSSTQTEPQDRERLLDILRRAVQHCPWSGQLWNRYILCAEEAKLPFPDIESIKHSATSENQLYKNGMESMIEMYVAWCGFLKRTAIEATATDEAVDLADVGLRAALEDVAVVGKRLYGKEFQGDPKFRLERIYIQYLTEKKGAIDEARAVWSKLSDVQIHADSYDFWIRYYMWEMFVFSSNSQPARSPTPSSSVSSCLRVPKFGTAVLHAAANRKTIDWPERVLEVYLQHCNDYEHPTSVRRATDMVHRVGKAVRRRRQREEEAKSAAFAAYYAETESAAVNGSKRKRSEHKEDDGHKDNKRQRTGPEEAAPSGSAEPNAKRDRENATIIVTGLPAEVTKTKVRQYFKEYGHINSVTALVRDEDGSSSTALIEFASPDEARSALLRDGKYFGQSQLSVQSGYDLTVYVANFPPVADDKYIRDLFKDCGEILSIRWPSLTVNTHRRFCYVSFRDRTASAKAVSKEGTLLNGKFSLLAKYSDPSRKKTREGAVAEGREVIVNGLDKAATEDEIRRIFSKLGNVSRVTLPVNLAGKNRGFAFVAMETKEEADKAIEEMNNTKLRNQILRVELSKESKVKHAAKTTTAGEPTSPSSKPSSSADAGKGAPSAADIATRTVALMGLPDTVNDARIRALVEPLGAIVQLVLQPAHGGAKIEFADAATAGKAALQLDDFDFDGHKLRTGSVDDLRRAKADRTDDRIVYGGGGRNSNSNKDKPRLMPPPTSVRRAGGPKRGIGFPTRKVRDARPAETEDGKPAPKTNADFKALFLGAEDKKDGAAGEEGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2K6</accession>
    <name>A0A367L2K6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_4640</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2K6"/>
    <dbReference type="STRING" id="1330021.A0A367L2K6"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000085">
        <property type="entry name" value="MFS peptide transporter Ptr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018456">
        <property type="entry name" value="PTR2_symporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01023">
        <property type="entry name" value="PTR2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="290"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="380"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="417"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="458"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="510"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="541"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="573"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI08656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="634" mass="70008" checksum="B07A17F2555FC28B" modified="2018-11-07" version="1">MASAFPIDNDAITQIGPPYHNHGHDVKTTTTTTTPTDDTDKKNISDMSKGSLARHSVASASSTDDDYDGRPTQEEMHSLRRVSGKIMWSMWTIAFVELCERFSYYGTSVLYTNFINHPLPPGSKTGAPVHPGDLPGALGMGPKAAQGLNLFNLFFAYLMPLVGAWVADARMGRFWTLHLAIGISTIAHVVLVVAASPGVLANNKVSFGVFILGLMVLCVGTGFFKANVSPLLAEQNDDVRPRVEVRKGERVIVDPAVTNTRIFLYFYFCINVGSLTGQIGMVYVEKYVGFWVAFLIPTALFLLAPFVLGSQKKSYKLKPPTGSLLSKFFRLFLYVRSKSSSLASFDWNLAKPSNVPVHERPAWMTYDDAWVDEVRRGLKACKVFLFLPIFFLSYNQMTGNLTIQAGTMELHGVPNDIIQNLNPISILIIIPVIDHLIYPSLRKLGFAFTPIKRMTTGFIIAALSMVASAVMQYYIYQKSPCGWYANKTIVENGQKRPCAPAPINVWAQCLPYIFIGIAEVLANVTSYEYAFSKAPENMKSLVMSVNLFMSAISAALGQAFTPLSDDPLLVWNYTVVAAIAFAGGVAFWLCFRHLDSEEDKLNMLKKSEFIGHQKPGLSSKAMEAGEAANEHPEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L356</accession>
    <name>A0A367L356_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_4635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L356"/>
    <dbReference type="OrthoDB" id="5264002at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI08837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="104" mass="11576" checksum="758678DD3DBCB1C2" modified="2018-11-07" version="1">MPLLFPILINSTTFIDAQADYSYNCYAAISESLFLATSLREILLALRITPTPKAPPIISLPSKVSNFTDLFSKEKASALLPYYSSQDYYICLRYNPDSSLPALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3P8</accession>
    <name>A0A367L3P8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5146</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI09049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3P8"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI09049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="143" mass="15891" checksum="F563F66947B15C29" modified="2018-11-07" version="1">MKQEKAIAQPPFPPPIHPMVRPTENAHIVGNVLTIVPSSRHVNALGVSMDSKNIKARDGKISDESVEMIKVGRETDFVSMTRNPQCMIVLFLWSGSTVSELAMIINRMDFISLPVKVSKPYDVIMRINDARLTNQVGETTGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3R5</accession>
    <name>A0A367L3R5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5105</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI09064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3R5"/>
    <dbReference type="STRING" id="1330021.A0A367L3R5"/>
    <dbReference type="OrthoDB" id="3827557at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39609">
        <property type="entry name" value="RFEG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39609:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR RFEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="140" mass="15271" checksum="D95316E865B714E0" modified="2018-11-07" version="1">MSSSSSSSSSSSMNRYWIPYLDIHRKVITQELQFHLGPQATVRPYTLQGEDGFLISTPGACLTDEQIDDICRKSKQLWERQAAAKIRENPSKSLKRPLHQPIVISNSQGGRKRRSLPPPPLTGAQAVGVSIAASAAASVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4B3</accession>
    <name>A0A367L4B3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription factor TFIIIC triple barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_1517</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4B3"/>
    <dbReference type="STRING" id="1330021.A0A367L4B3"/>
    <dbReference type="OrthoDB" id="1877767at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019481">
        <property type="entry name" value="TFIIIC_triple_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10419">
        <property type="entry name" value="TFIIIC_sub6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor TFIIIC triple barrel" evidence="2">
        <location>
            <begin position="39"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI09266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="429" mass="48037" checksum="5A5AD54513581364" modified="2018-11-07" version="1">MAQEATVGTENPGALDVDEVLRQVMHDDQEEWEYEYSTTDTETFYLTIELSYPEFKGRSTLDLPHSRGGYYNGGNLGSVASRAQKGGVLSEDEENGKNKDDDGDDEDVDMGNDATKAKTTKAKTTTVEDVGDDEMNEDENTALVDLELTRSAIGTAQKQKKNKNKEPQRRDDKGKGKGAEAGGDDDDDEAEDIQILDLHSARPLISYRGRVFEGRWAEVIGTEAILAHHDKKEPLPALRNLADGIDMLAASSSRIMTTEKIVNAKEAEVDELAAIRDEWNIRIPAGKHRTQEKMQQLRFLENMIALKKKKGQTDEVTVYAADGAGKNWSDNRGVDYKPRLAKRRTAIDEEDSEEEKEREGGGEAEGMESPDARRRRILTQQQRRRRRRQRRELMVRDQEVASQASRSELTRDEAAEGRDDEGDATMTGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4D2</accession>
    <name>A0A367L4D2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI09072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4D2"/>
    <dbReference type="OrthoDB" id="4928078at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="351" mass="38969" checksum="F8BF7EF874FAB72D" modified="2018-11-07" version="1">MQATATNIQPNCQIRMVTHQARAKQVHVAPEQVIWLHRTAVGNPAQAANPPKAENPGFWKGIGASASQGFGGNLGFGVSNLVTGGLGYAMGSAMSGKSKPSDAASESRATQGRQPTQQLQATQATQVTQESEATQATRAMQEPQKPQRGKQQIWLERKMAFKRKTSVTTGSEPTTRLGDSEELDTKEKASNTTEALSREQADQAPTSTSESRPGYSQHLPWTSPEGGEHYCKRQGWYEENGRFLADEEDTTKWKSSKGVSFNWSAPVVEDCRWEGSPPFCGTADEYTGAVVDGWKLIIGDRIRKKAICKKPFSRYYSGQDCCRKFDARNKCRRGYRRLWCKTKNPWDYEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L539</accession>
    <name>A0A367L539_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_3927</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L539"/>
    <dbReference type="STRING" id="1330021.A0A367L539"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF10">
        <property type="entry name" value="L-ORNITHINE N(5)-OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="552"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI09534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="594" mass="66899" checksum="7827D5B2D34C5C39" modified="2018-11-07" version="1">MSNVSYSQFVCVGAGFSGIALGATLKRWYGIDNVRFFERHADLGGTWFINTYPGCACDVPVILYSFSFAPNANWSRTLPSSAELWAYLKRVADEYDLTSKMTFGADVIRCEWRQDSNRWRLQVRDVKSGAVFHHESRFLFCAGGVLVRPKVPDLPGLSSFAGTVLHASQWSNDVQINDKKVVVVGNGCTAAQIIPTIIHRTRHLSQFIRSKQWYLPPIDINDKKVVVVGNGCTAAQIIPTIIHRTRHLSQFIRSKQWYLPPIDVAISDFTRWLFAHVPGILFLARFWAFCNYEDHLRGFYMTEAGARYRSRQKGAAVGYMKRAAPEKYHHLIIPDFEIGCKRRIFDSGYLRSLHAPNISLSDEPIVEVLPDAVRTRDGTLTPADVIILATGFVTNQFLHGVDLVGRGGVTLDKHWSKYGGPEAYNCVALNQFPNMFMILGPNTVTGHTSTIMAIENGVNYALRVIKPVLDDDNGVVEIKPGAEARYSREMQQALRKTVWFSGCHSWYNHEGPDGKTWNAMTYPRTQWDYWYQCLFPAHRDWSYVNATPTRTLLRSGVLVLVGLAVAAVGVWLAVEKRGPLVGRGFSYVRPHSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L584</accession>
    <name>A0A367L584_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TAP42-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L584"/>
    <dbReference type="STRING" id="1330021.A0A367L584"/>
    <dbReference type="OrthoDB" id="10261753at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051721">
        <property type="term" value="F:protein phosphatase 2A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035303">
        <property type="term" value="P:regulation of dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.540">
        <property type="entry name" value="TAP42-like family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038511">
        <property type="entry name" value="TAP42/TAP46-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007304">
        <property type="entry name" value="TAP46-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933:SF9">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04177">
        <property type="entry name" value="TAP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="367" mass="39691" checksum="7745D7E512DE7D44" modified="2018-11-07" version="1">MTTSSLDDESLGALFRRAEAERAAIESSSPTSSADHGKRVAGAVTLYERVQSGITSLSLFSRNEAIDDVSTTSLPFLSVEWRLAELEAARWEKDEDGVDGRRAALGRARERYGRFLDLVDAYGLVVGPYEPLLERFRSRLPEEFSVVDEVGGGGGLAARRDAKIASFRAEKELRRRRDEAFRSVGAGVDDDEGEAVGEAGDDELLRGFYLAELAFGIHSAFNGVDAIDRELRLLSLAASAPPTTTKARGQDQEDDASRLDQPLLSTAARPLLSRGGKPLQPFTLVGSRADRARAVFRPGHNLPSMSVDEYLAEERRRGGILDGGGGGRAGGGKRPVGGDEDETYKARAWDDFKDDNPRGSGNTLNMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5M7</accession>
    <name>A0A367L5M7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_4115</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5M7"/>
    <dbReference type="STRING" id="1330021.A0A367L5M7"/>
    <dbReference type="OrthoDB" id="159449at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000003">
        <property type="entry name" value="GTPase activating protein (Evi5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000027">
        <property type="entry name" value="GTPase activating protein (Evi5)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000001">
        <property type="entry name" value="TBC1 domain family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23436">
        <property type="entry name" value="RabGap-TBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="5">
        <location>
            <begin position="251"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="541"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="584"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="691"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="872"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="924"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="767"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="47"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="95"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="584"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="698"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="925"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="942"/>
            <end position="955"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI09729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1000" mass="109278" checksum="694664BB558DC447" modified="2018-11-07" version="1">MATTPAEAQTRHDSHPHNSTIAADEPGTDRTNMAHDSMVTVRLSEPSSVVDAAASDSASASKTTSIQSSPPSTDGSHVVANTDEADFDSPRRPDSSMTLSPTGSHSTVQDDMTPEADSSMDGHETDSSDDPDEVDWEQLEKTEDEQVKDDETDNSTALLLARLEQENAKLATNPKSVKVQAVDKATPTKPRPPSMAQLRQMMKGPAPPALRYSMLPPPPMTDLEFYAALVKDYQQTAARLPTLLSNKIRKGIPPPLRGVVWQSMSGARDALLEEQYDAFCGEASPYELLIGKDLGRSFPGVDMFRDPEGDGQRMLGRVLKSFSLYDAKIGYCQGLAFLVGPLLMHMPDKQAFCVLVRLMERYDLRACFLPDLSGLHVRIFQFRELLRLNFPILSNHLEDLQVETAYVSQWFLSFFAVTCPLPMLFRIYDVIFAEGASETLMRVALSLMRKNEARLLACSEMEDVLQLLLSRGLWDCYHYNADEFVHDFVSLTSVVTREKLAQLEQGYRESLVATSSAIRASDITTAATRFLGRIWASSTGAKTSTLQPGQGAPSRPLSLLRRSTSKQSLASTLYSMEASSVSVTSSASSSTDATSMSRNSANTDDEGSSRESTPVGLKSTASVKATDDKYLHSQIEDLLTALSELQRNNSLVSNQLQWEREERAEDRKAARQLLRGLRQKAAVLRGQTAALNDAGTTAEDESVPAESETDEATEAPESVAEEVTPLAEDADVREPQWTKEMCDLVERAESRFGGDDEQHRSSMLLSKSQLRDELRSAQDQLTSATCQSQDLNRRIHDMDQEIASLKEQLRERHNHVRTLHQDKQRLEKQVQGLRCRASASSTCDGGIRDSEMENKAMPAGLRELKLGRSQSIPSPASSFCKRGSSLPRFHEAGPTSKSVGGATSGSEHEALVLELVQAKTAEAMAKQEAEEAKQKLEALRKSSSSSESGGLTASNSMTLGMLSRFTGHGNVEQGTKAAAAPPTAAAGGSMTSGGFWSRLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5X3</accession>
    <name>A0A367L5X3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_4014</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5X3"/>
    <dbReference type="STRING" id="1330021.A0A367L5X3"/>
    <dbReference type="OrthoDB" id="191364at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009092">
        <property type="term" value="P:homoserine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000094">
        <property type="entry name" value="Homoserine O-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00296">
        <property type="entry name" value="MetX_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01392">
        <property type="entry name" value="homoserO_Ac_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF11">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000443">
        <property type="entry name" value="Homoser_Ac_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="5">
        <location>
            <begin position="66"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000443-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI09821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="457" mass="50404" checksum="5E466B2708F95B90" modified="2018-11-07" version="1">MDRPSANHGGRYKRVSCQLENPLAALVSDQQMAIVPEFTLESGVILYNVPVAYTVRGELSPEADNAMVICHALTGSADVSDWWGPLLGGPGRAFDTSRFYVVCINSLGSPYGTASPVTAKDGDPSKGRYGPEFPLTTIRDDVRLHRLLLDDLGVRRVAAVIGGSMGGMLVLEWAYFGVEYVRCIVPIATSSRHSAWGISWGEAQRQSIYADPKYDDGYYALDDPPATGLGAARMSALLTYRSRNSFEARFGRNTPDPSRAQAMVEDEPVVEHFRIHNDGHAVKRATTPRGNGTDGKRKEVNGRSTSTYFSAQSYLRYQGTKFVQRFDGNCYIALTRKLDTHDVSRIRASTTAEALRLIRQPTLVLGIESDGLFTFAEQEEIATHVGDARLERIVSPEGHDAFLLQFEQVNRHILTFLKEVLPDMMGRGEEVPEAADLGRLTVSSKFGEAEVEDMTAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L675</accession>
    <name>A0A367L675_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Catalase</fullName>
            <ecNumber evidence="13">1.11.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L249_8396</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 14">Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Alkaloid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the catalase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.6" evidence="13"/>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI09919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L675"/>
    <dbReference type="STRING" id="1330021.A0A367L675"/>
    <dbReference type="OrthoDB" id="6880011at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009820">
        <property type="term" value="P:alkaloid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042542">
        <property type="term" value="P:response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08157">
        <property type="entry name" value="catalase_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.180.10:FF:000001">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.180.10">
        <property type="entry name" value="Catalase core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018028">
        <property type="entry name" value="Catalase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024708">
        <property type="entry name" value="Catalase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024711">
        <property type="entry name" value="Catalase_clade1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011614">
        <property type="entry name" value="Catalase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002226">
        <property type="entry name" value="Catalase_haem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010582">
        <property type="entry name" value="Catalase_immune_responsive"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020835">
        <property type="entry name" value="Catalase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11465:SF9">
        <property type="entry name" value="CATALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00199">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06628">
        <property type="entry name" value="Catalase-rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038928">
        <property type="entry name" value="Catalase_clade1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00067">
        <property type="entry name" value="CATALASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01060">
        <property type="entry name" value="Catalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56634">
        <property type="entry name" value="Heme-dependent catalase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00437">
        <property type="entry name" value="CATALASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00438">
        <property type="entry name" value="CATALASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51402">
        <property type="entry name" value="CATALASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0017">Alkaloid metabolism</keyword>
    <keyword evidence="5 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 13" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="8 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 13" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catalase core" evidence="15">
        <location>
            <begin position="13"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="343"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038928-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCI09919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="489" mass="55680" checksum="215406B5659EF02A" modified="2018-11-07" version="1">MDSYRYNEKPVYTTSNGAPIESHQAWQRLGSHGPLLLQDFHLIDQLAHFDRERIPERVVHAKGAGAHGVFQLTHDVSDISSIDMFSSVGKKTDCIVRFSTVGGEKGSPDSARDPRGFSVKFYTQQGIWDWVFNNTPVFFLRDPTLFSVFIHTQKRHPQTNLKNATMFWDYLSTHPESAHQVMHLFSDRGTPYSYRHINGYSGHAYKLTKPDGSFVYVQMHLKTDQGIKNFTNDEAAAKASENPDWHTQDLFDSIEKGQFPSWTVHLQVMTPEQAEKFRFNILDLTKVWPQKEFPLRQIGKLTLNRNVDNYFAEVEQLAFSPSHMVPGVEPSADPVLQSRLFSYPDTHRHRLGTNFRQIPVNRPLNAFNPFQRDGHMAVNGNYGANPNYPSSYRKLTYKPVKPTVTHEKWSGEAVNALFGDVTDDDFVQAKGLWDVLGRTPGQQDNFISNVAGHLSAAQTDCRNRTYNMFTRVDAGLGKAIKEQTEKLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6H7</accession>
    <name>A0A367L6H7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_8692</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6H7"/>
    <dbReference type="STRING" id="1330021.A0A367L6H7"/>
    <dbReference type="OrthoDB" id="4703at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052416">
        <property type="entry name" value="GTF3C_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15052:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15052">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="640"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="743"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="20"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="39"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="647"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="664"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="743"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI10009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="765" mass="84587" checksum="A2CD89CC03AB6B6A" modified="2018-11-07" version="1">MRTRRSNRTKRFTVEKFNFESGSEEGASPPSRGERDADFGDEDADADVREDFEEEEGEEEEEEDDEENEEDEEGGDTAAGPSNEANHGGRRKTVAAARAAPRRPRRRKTQPTSVPSSSTDYRAVEPVPSDSHVYQSYSGPYNRTLRGQSLVAIWYGPRKQDMGVCQQLLDRWLHRTVLPPKSRRTWDASVWVPKGDLKREAALAERWRVGCVREEAARVLTPDEAKPYRSLDRPLSVLLGPYPNQRVITFRPGDAYCLEQDGTPYADDGDAGAKEDRVPIGWMLDVGGIVISMDWAPGQEKEQRLALAVVPHADEDLFDFEAEHRKPDFLRHGVVQIWAFLADTGNGFIRPSTRRPRLLKTLCFDCGRARRVKWSPVCDHLAVICGDGRVCVVEVEGTKRPERIQAPLATLNLSNEEGVKATVTAWATFNRLIVGYSDGSVGLWSVQPACLLGRHALHHSDVVDLATGYPTMPYLVASSPIGGPMRLVDLRSPSCESTMVQINAIRWQANLLSWSDHLLGFFSFYPSANALETRVGFMFHRHFPLVRHVFTGECLLSCLAVGRTHPYLLIGTTDGTLWSLNPQCELFKGRMPSQDRLRIFQHEHRPAERVPSGLPAAGRGASGVVHGFSVEKYAKAVPEAKTPVSAKKAKKRKKSRKKRGGGEDAADDDENGDDDDDDDEAGDEGGGGDEPLSLTDIARGIVHEPLTRITTVVWNPNPGYGCWAAASMASGLVRVLDLGLEINEDSDEDEEAGSDVQMASPGETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6K2</accession>
    <name>A0A367L6K2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoribosyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3834</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6K2"/>
    <dbReference type="STRING" id="1330021.A0A367L6K2"/>
    <dbReference type="OrthoDB" id="5416609at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036424">
        <property type="term" value="F:L-phosphoserine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050582">
        <property type="entry name" value="HAD-like_SerB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344:SF20">
        <property type="entry name" value="URACIL PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13207">
        <property type="entry name" value="AAA_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12710">
        <property type="entry name" value="HAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="1">
        <location>
            <begin position="466"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="666" mass="73422" checksum="A544A750486FF2C0" modified="2018-11-07" version="1">MESSSTHCPETPRNPVIVGLYGLPGAGKSFLLSNNLKFVLDPRKFVLYEGSDKIASLVSGGLEAFHTFEEEEKVFWRERAIDEVSRQSAALGKAAVVTGHYMFWHDDNEPSVAWTRHDSGTYTHVIYLAVTAARIAQRRRDDTLRSRPEISIDAIQKWQETEIAQLSDLCRRHGILFTLVSDESPSRVLALLLHFRQDSVDGNSARAIMELDRLVPNRERLETMLVLDADKTLAAEDAGTLFWQILADSQPSARKKCPLQELFGGPMGYSDQAFRQATLLYEEAATDEEYERLCAAVASSIDMYPEFVSLLRSAAAESHVGAVVVTCGLARVWEMILEREGLSSAVKVLGGGRLANGYTVTPAVKAAVVSQLRNSDQLHVMAFGDSPLDLPMLKEADEAIVAVGDVATRSRSMDAALAEAIDTGFRARQVLLSKNATQRLNDMLLPPTSLSELVMSRRNSPVVHSTDTNAARLLMTPTRDAAVAGPALRRAHREVGRYLAIQHLSDVMGLEDYEMRHVQGSVTNGHRLKDEERTLIVALMRGGEPLALGVNDVFPRAMFLHADSASSVDEAHLHGMRSVILVDSVVNTGKTLLLFIERIHQLEPGMRVFVVAAVVQAEAVSRRHALAVAMERHNVRMVSLRLSDNKFTGTKGTDTGNRLFNTTHLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7A5</accession>
    <name>A0A367L7A5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Carboxypeptidase</fullName>
            <ecNumber evidence="13">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L249_8444</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Release of a C-terminal amino acid with broad specificity.</text>
            <dbReference type="EC" id="3.4.16.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="13"/>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7A5"/>
    <dbReference type="STRING" id="1330021.A0A367L7A5"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.410:FF:000001">
        <property type="entry name" value="Carboxypeptidase Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008442">
        <property type="entry name" value="Propeptide_carboxypepY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF113">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CTSA-4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05388">
        <property type="entry name" value="Carbpep_Y_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Propeptide carboxypeptidase Y" evidence="14">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF05388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCI10310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="550" mass="61636" checksum="AC0DCA3B63BF89C4" modified="2018-11-07" version="1">MRLSTYALALGASSSALGLQDQKVLSGSHVGQNAFSMSDFESWTKPLTDAFGEMTSEAKTAWRELSELMPEAVEAVKKQVTGFKPKKHTRIQNSKWDHVVSGADVQALWVQGEDGQSRRKVGGKIDNFDLRVKKVDPSKLGVDKVKQYSGYLDDNEKDKHLFYWFFESRNDPKKDPVVLWLNGGPGCSSLTGLFLELGPASINKKLEIVNNPYAWNSNASVIFLDQPVNVGYSYGGGSVSDTVAAGKDVYALLTLFFHQFPEYAKQDFHIAGESYGGHYLPVFASEILSHKDRNINLKTIMIGNGLTDGYTQYEYYRPMACGNGGYPAVLDESTCKSMDSALGRCQSLIKQCYDTESAFLCVPASIYCNNGLIGPYQRSGQNVYDIRSKCEDESNLCYSALGWISEWLNKADVKEALGVEVESYDSCNFDINRNFLFQGDWMKPYYRLVPKLLQEIPVLIYAGDADFICNWLGNKAWTEALEWPGHKDFAGAKLKALELTADKDSKYGEFRSAQNLTFMQIYQAGHMTPMDQPEASLDFFNRWLRGEWVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7J0</accession>
    <name>A0A367L7J0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ras-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_4361</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7J0"/>
    <dbReference type="STRING" id="1330021.A0A367L7J0"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000080">
        <property type="entry name" value="Ras-like GTPase Ras1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI10386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="23929" checksum="9C478013690F72CA" modified="2018-11-07" version="1" fragment="single">FLREYKLVVVGGGGVGKSCLTIQLIQSHFVDEYDPTIEDSYRKQCLIDDEVALLDVLDTAGQEEYSAMREQYMRTGEGFLLVYSISSRQSFDEITTFQQQILRVKDKDYFPMVVVGNKCDLDEREREVTWQEGDALAKSFGCKFIETSAKSRINVDKAFYDIVREIRRYNREMQGYSTGSGGNSGINGPPKPMDVDDGEREEGCCSKCVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8B1</accession>
    <name>A0A367L8B1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4326</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8B1"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="242" mass="27614" checksum="9E60B8B455983150" modified="2018-11-07" version="1">MDGARLKLHGDDRDEAEDRRQSDGAPEPRSEEVVGRMSLASFFLSLVFVLYFPQRFCSWRGGKRPAFFDDRSVLPCRPTNEMGSCLLLWQRGRGREGVKREGESDLEMGRRYSVSSTMTDFFPRRQAKLLLKQTCVCGLEHDAQQPPVDGLSLRPVARQDLVKNDSRPTYRCYVDDDDDDDDDDDDDDDDNDDDDSSNNNNNNEQRARLKNTGRILGHLESTDKLDVIDTGATWELRGIRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L921</accession>
    <name>A0A367L921_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">25S rRNA adenine-N(1) methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_5333</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of an adenine present in helix 65 in 25S rRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the BMT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L921"/>
    <dbReference type="STRING" id="1330021.A0A367L921"/>
    <dbReference type="OrthoDB" id="5954793at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016433">
        <property type="term" value="F:rRNA (adenine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03044">
        <property type="entry name" value="BMT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021867">
        <property type="entry name" value="Bmt2/SAMTOR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21008:SF1">
        <property type="entry name" value="25S RRNA (ADENINE(2142)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21008">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SENSOR UPSTREAM OF MTORC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11968">
        <property type="entry name" value="Bmt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI10917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="303" mass="33470" checksum="B7BE9B1F533A4D0A" modified="2018-11-07" version="1">MGPKSKRLTNIQAGRPPTAKPRRAMSRRASRAVINRHHQLEKTRRLAGERGDAAAAAAATAELASLGGLRRYQEASLQGQSVERGGDTSRVLVEWLPTGRDPGPWRRLRMLEVGALSTRNACSVSGLFDMVRIDLGSREAGILQQDFMQRPLPESEADRFDVISLSLVLNYVSDAAARGRMLARSLSFLRRFDGEAPSDITNTVTASALPCLFLVLPRSCVTNSRYFTATRLKELMDMLGYALVNDKMTQKLAYSLWTRRRDVATAHVTLPKTEINPGRDRNNFAITLDSSATIETSGPEKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L970</accession>
    <name>A0A367L970_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">EH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_5298</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ketopantoate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L970"/>
    <dbReference type="STRING" id="1330021.A0A367L970"/>
    <dbReference type="OrthoDB" id="73846at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050838">
        <property type="entry name" value="Ketopantoate_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013332">
        <property type="entry name" value="KPR_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765:SF2">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02558">
        <property type="entry name" value="ApbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EH" evidence="7">
        <location>
            <begin position="56"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase N-terminal" evidence="5">
        <location>
            <begin position="190"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="6">
        <location>
            <begin position="397"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI10973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="580" mass="63907" checksum="79FF1B8D5F84783C" modified="2018-11-07" version="1" fragment="single">GSRKRWQHSIPPPERKRYEAVWASNRGSLLLSVQNSSSSSFSSHSHSHSHSHDEEEESQDFVANIIVRNLWRRSRLPDEELAEVWDLVDRSHRGALSRVEFVECCWVGWMTLMTLMTLITLINPYQPYCLRHGYISYTNVPLNHDKTSFPPPKLYAWTAANIDPSSPPPPPIPSPEPEQGECTSSSPPPIFIIGGGNIGRLFAASLARLPSRPRVTVVLRSRQQLRDYVSSSRGIQLVTPTSSSCPSHDMVAPTSPSISLESWSEIPPPTGPIRQIPDLKTVIVATKVTDAVDATLSLRRYLGPRSVVAMAQNGFCPFWPPQGDEYLARGWGDKTNAPSFMACVVSHGLYADPARPVGTSVHAAVGDVIFGPDYLTRSLLSAPMLNAKAVSPCRLWLSQLEKLVYNSTINPLTALLRCPNGSLVSTPTRSQVVDKVLAETSHILLTFIAHRNPFFSRPPPLAEESADPTLGPDRVSSSSLSSFFSAGNLRASLEAFIPRVASNRSSMLQHVLAGLPTEVRAFNGWLVDRAAELDPAFEPTLHRRLVRLVDMAKPDDAPCDDDMLRPSFSRTIIIIVCLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L976</accession>
    <name>A0A367L976_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NADPH:adrenodoxin oxidoreductase, mitochondrial</fullName>
            <ecNumber evidence="8">1.18.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_5357</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>2 reduced [adrenodoxin] + NADP(+) + H(+) = 2 oxidized [adrenodoxin] + NADPH</text>
            <dbReference type="Rhea" id="RHEA:42312"/>
            <dbReference type="Rhea" id="RHEA-COMP:9998"/>
            <dbReference type="Rhea" id="RHEA-COMP:9999"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.18.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8 9">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ferredoxin--NADP reductase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.18.1.6" evidence="8"/>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L976"/>
    <dbReference type="STRING" id="1330021.A0A367L976"/>
    <dbReference type="OrthoDB" id="333024at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055275">
        <property type="entry name" value="Ferredox_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021163">
        <property type="entry name" value="Ferredox_Rdtase_adrenod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48467">
        <property type="entry name" value="GLUTAMATE SYNTHASE 1 [NADH], CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48467:SF1">
        <property type="entry name" value="GLUTAMATE SYNTHASE 1 [NADH], CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000362">
        <property type="entry name" value="FNR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0274">FAD</keyword>
    <keyword evidence="3 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 8 10" id="KW-0521">NADP</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="11">
        <location>
            <begin position="43"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="205"/>
            <end position="208"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="249"/>
            <end position="250"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="431"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="438"/>
            <end position="440"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR000362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI10977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="529" mass="57700" checksum="72873A48B7AD64F3" modified="2018-11-07" version="1">MLQHSNYPFCGVFRVGRLHATKLASEYSTATNVSTDRSNAPFHLAIIGSGPAGFYAASRVRKRLPHSRIDIYEALPAPFGLVRYGVAPDHPEVKVKLNAPNCARTKFKEIAGSPNVQFLGNVSIGRSTRSAFHCVVRLSSLMRHYDAILMAYGASEDKKLGVPGESSLSGIYSARQFVGWYNGHPDCADLTPDLTKGEDAIIIGQGNVAFDLARMLLDDVDVLRKTDITERALAQLAKSRVRRVRVVGRRGPMQAAFTIKELRELMTLPGVAFNPIERSLVPDDLRSVPRPSRRLMEVLLKGASASHLAALRSWSLDSCLSPKRFLSDNDTHERVMSTEFDVTKLLSPFDPQSPICASGNRHVLPSDLVIRSVGYKSTALAGFPEAGIQFDEKLGVVMNDGLGRVTRFVSPSHGGDAVETQQVAGLYCAGWLKRGPSGVIATTMQDAFLTADAIIGDWLAGAQFLRAEHEKSPAGGWEAVRQEAGSDTSFAVSWDQWLKIDSAERSRGKSCGKPREKFTSVEEMLSVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9F4</accession>
    <name>A0A367L9F4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Fatty acyl-CoA reductase</fullName>
            <ecNumber evidence="1">1.2.1.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_5216</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a long-chain fatty acyl-CoA + 2 NADPH + 2 H(+) = a long-chain primary fatty alcohol + 2 NADP(+) + CoA</text>
            <dbReference type="Rhea" id="RHEA:52716"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="EC" id="1.2.1.84"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the fatty acyl-CoA reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.84" evidence="1"/>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI11049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9F4"/>
    <dbReference type="STRING" id="1330021.A0A367L9F4"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102965">
        <property type="term" value="F:alcohol-forming long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080019">
        <property type="term" value="F:alcohol-forming very long-chain fatty acyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026055">
        <property type="entry name" value="FAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011:SF45">
        <property type="entry name" value="FATTY ACYL-COA REDUCTASE CG8306-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11011">
        <property type="entry name" value="MALE STERILITY PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioester reductase (TE)" evidence="3">
        <location>
            <begin position="833"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="528"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="701"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="575"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="637"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="725"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="748"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="763"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="777"/>
            <end position="801"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI11049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1253" mass="138602" checksum="CD226A3542C18583" modified="2018-11-07" version="1">MWREHLQGKTGWLPVARSRMSSSRDLAQVATTVETRLPPSMLETSTSRKTLKAEAAEDEASGEKAERTKNNVEKAVYVCMRRIFQGTNKTIRKPKIVQKVIEKHRSDRHVNLLIRKYKMPILSKVTIELLHDGTFESTAKAKARFPDLNDAVFAKTDNDEAAEAQALENLEMLESEFPDETVGAARDTTDDEAVIANGTTFTSDILEVAKPPATKTSSDAAEMPATSDAVEMPRKVTAPTPVVETGPLEAPGPIEMPTPAAPAPDVIDPPISSFLPMPAQHQLLSHLQQILEAACFDFCKRTMPDVLEHNKWEYAESVELHRWMEEFLRRKSRFPEPNRTTSRPLRQIFNNAADIRHICVHRQPVETWRVNDFLSSSEALLSLLGDMLRGDRVAKLRRTIHIVTEEVESSKRASLLETENIMRRIDSQRIELDLLEKRTTLEMGRRAKDAEIRGGNKVLRVMASSSYTRPERPFDWSPDLSLDGANELGGVDGAEARVETRPAARTEVLAETRRCDIRVEREPEVQGVTKTEARVGTKPEAQAVAKPEVPAETKPVANPQARVETKSEASPQARTEVKPITRIEGRRESPIEAKPQSLVNNQAKGGTASKEDASTIIARIQDKLAKKKSAKAATTTVGRSGDTTSSVSATAGVAKGKGSDQDNRPNAQEESVKVRVSQQAKDVKKEGLQAAEKAVNHLIGQKGTVQQLDQPIKVGASKPVGGAKNEAEAKDGVSKQEGESSSTQGGESKSKQETEVSSKQESEPSSSKQESKPSSSKQEESEPSSKQEAERSDNRGEEQQREVVAAQLPNAESLQVNEAQVQDFYRDRSVFCTGATGMLGLAYLVRLLLDTPVSHVYAMARGGEKRMWQVCSEYLSSEQVEALQKSGRLTVFDGDITHPNLGLSEDQVDTLRKKVSVVVHAASTVNLVKPLHAVADVIIYSSLAIADFVLSLSHLERFVYVSTAYSSTFLRRDLTGNVIGSEAVITEKVHQLRTMVETAEAELADIREYGTTPEFNFADYLYPYSYAKNLTERLLISRFEKHGQSDRLLIFRPSIIGPAEQLPRPNFEIAGSTPVTTFMAAAIMTPPLRMCFASPLDDPSTATIDEVPVDIVVNRLVVHTAYGSAGPVHAAAGRDGRTLSETLWLQALDLRSWWWWKPSGAWTSKDWSAKGVCKLSRLFKVCGCDFVFDQAKSEAVWATMSEQEKSLWPFWPTPAAEDKNHALGREKALKLLCDKFASRTCLPTMITRFMYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9H7</accession>
    <name>A0A367L9H7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acetylesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_7534</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9H7"/>
    <dbReference type="STRING" id="1330021.A0A367L9H7"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01846">
        <property type="entry name" value="fatty_acyltransferase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051058">
        <property type="entry name" value="GDSL_Est/Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648">
        <property type="entry name" value="GDSL LIPASE/ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648:SF22">
        <property type="entry name" value="GDSL LIPASE_ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016984750" description="Acetylesterase" evidence="2">
        <location>
            <begin position="18"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI11075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="37047" checksum="5C425571A33C2EEB" modified="2018-11-07" version="1">MWPKTLCLAMLIVRTMTTRPRMEHLVSFGDSYTDESRSQYFVLHGKPPPAGLILPPSKLTLSGGFVWPRIVAQRTGAISYNYAVSGAMCSDDLIPGRFLNATGLPFPSVSGYELDAFKADSAIFSGRRPNNTVYTLWIGTNDLGTNGFLGNAQRPGATLRSFVDCIWGVFDRLYAAGGRRFVVFNQIPLELAPMYATPGAAGHGNVQFWRDPASFNMSEQRDKVLRYTLTVNAMLYEGAPLRLRSRWPGATISVLDAHSIFTKAVAKPHRFLDDPANAVTPYRNCLSACIDSPAKRSSFLWYDELHPSEKMHEVLSQAFIDLLNGSSKYGKTFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9I2</accession>
    <name>A0A367L9I2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_5226</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9I2"/>
    <dbReference type="STRING" id="1330021.A0A367L9I2"/>
    <dbReference type="OrthoDB" id="624345at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051701">
        <property type="term" value="P:biological process involved in interaction with host"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000606">
        <property type="entry name" value="C2H2 transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000758">
        <property type="entry name" value="C2H2 transcription factor, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="120"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="23"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="185"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="272"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="435"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="298"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="313"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="380"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="435"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="458"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="506"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="522"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="662"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="698"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="737"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="765"/>
            <end position="776"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI10892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="792" mass="87088" checksum="1A538083FA22E503" modified="2018-11-07" version="1">MAAAFRPVNSSIIPQTINEDHHFHHHHHHHHHHQQQQHQPPVNRMADATPTQTSFVGQKPLPTSPFPPDRSEGDVSAKSRDSMDVDGDESDADADAAASDDDSVAADGSKSGKKKKSQRFYCTDYPPCNLSFTRSEHLARHIRKHTGERPFQCHCSRRFSRLDNLRQHAQTVHVNEDIPIHSLAATGSRFQRQMRTGSDRARQAGNRARASTGGSAGGPSRGHAKSLSTSSIANISSVASSPYGAHPSAAADARRRPPPLVMAADPRARLSLESYRGGPDSPFSSASYRPPSPADYGTPTSATFSSTAQSSPRWTSGVVSPATSHSRSQSLYSTGSRTPGRRLSVPSGAHPFQNNAVVIGQQQQQQLPHRHPPPPPPPTSQQQQQQQQQQQQQQQQQQQQQQMQQQQMQQELQFQQRHQHLRQLQLQQFHCFAGHHPPQQQQQQQQQHHPHHPGLLNSSHSAVLPPSSSGSSSVTSPASSSSASASAPTSSAWSARREPSWGSAEEVWRRRTWHPDSRTYGQQQPQPQSQSQAQQPQRPLSHQQQLHLPLSAAAAQSVRPNPPPPMVNPTGSQTSFRLPGIESFDPLPSPMSVEAADAQPPPPPARRPVFEPPDERRNLNMYDASLQRGLTRLDIGRKTPPRDSAGAWASEVNQAVQAQAERVVRFDDQVGGRHQQTHSAPSPSPTPRNPKRFGWYHQPPPPPPPPPPPQSDARAAHVDRMVHPNFTGFSAFPVREQQQQQQQQQQHQPSSIMAAPPPPSQSQDRPPHGDPLRRLEALVAVATSEGSTATAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9P3</accession>
    <name>A0A367L9P3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9P3"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="96" mass="10441" checksum="798D6A1E00C6FA81" modified="2018-11-07" version="1" fragment="single">HSAYSGVGSIRSIGLTRTSLPPNHRSSKYVRVLQVGTLKYLEKIISISFSHLLNTNTSPASNSSSIASFRPSRDSSSSSLLRDHLPDSSTFHLLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9Q0</accession>
    <name>A0A367L9Q0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7444</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9Q0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI11136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="152" mass="17679" checksum="054B04A548350D32" modified="2018-11-07" version="1">MPGRLATRKIFDALQLQLDTLDERLRNYNAKRPETYEQGYKEAIKFFPEKKRPTSPERIYKKSFNKANKKTIAPNPPRLRKRHKGIPILIDRKAPRKRLSSQQLTFIVDLTLNFGRISLKSPIMLALLDTSAKTNILTTSTARDLNLEYRPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9S3</accession>
    <name>A0A367L9S3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_7268</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9S3"/>
    <dbReference type="STRING" id="1330021.A0A367L9S3"/>
    <dbReference type="OrthoDB" id="408964at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13118">
        <property type="entry name" value="POLO_box_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14099">
        <property type="entry name" value="STKc_PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.30:FF:000004">
        <property type="entry name" value="Serine/threonine-protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.30">
        <property type="entry name" value="POLO box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033701">
        <property type="entry name" value="POLO_box_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036947">
        <property type="entry name" value="POLO_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF0">
        <property type="entry name" value="CELL CYCLE SERINE_THREONINE-PROTEIN KINASE CDC5_MSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82615">
        <property type="entry name" value="Polo-box domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="71"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="483"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="522"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="976"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI11180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="976" mass="109030" checksum="F13814EFECAC5BF2" modified="2018-11-07" version="1" fragment="single">MSHRLAAARGGVDMDALSPRDVNAQRLPRTAEVKTKTAAQLRAAKDKEHPPPPPPEITEPFSSEHPNGAVYQVGKLLGRGGFAIVYSGRLLPTKNKYALKIVKSRMPPKMEQKFQTELQIHSKMKHNNIVKFLRAFSFESCTYLVLELCNNGSLMDMVKRRKGLTEPEVRFYSIQVAGAIKYMHAKGIIHRDLKMGNIFLDSQMNAKIGDFGLAALLVTGRDMQTIRRTTLCGTPNYIAPEILEKGKKGHDHMVDIWSLGIIMFAMLTSMPPFQSSTTDEIYRRARERDYEWPTAETTQKFISPEAKELVATMLEDADRRPDPDVIVQHPFFTLGFMPAEDDMTCRLRDLPPDSQDFYATRMSTSVQAQSYRNLKDLCRQCEVGPWNLEQKIRTQIWKEMAAEEKAGLTPAIPLAENLVYKPFEESQQHLRTKHVSSVVSRSSQLAAPTTHDLLADAPRQPIGLLRQPPQSFAAQQRALNRPLTVPAKAKPPPSGEPRPSASTRVRPRHEAPAGTLERATKSMRSSTRTALPSTRSAPSLQTVALNSEPDAAAVPKRHSSDSLRAATLFGPDEKPVQLTETKPDAILARLKRLQTELERALNSRTMAIISAKTVTPPHPHVVVKWVDYTNKFGLGYILNDGSVGCVLRNTPVAEGTGTAMLPPAGMLVRGAERHMMRRQDASYADRNQPAPMTDPIRFFENRGESGLWEVAVSPDKFRVAVAEDGTTEKMQPGRDVFEHRKRERIILWKKFANYMMAYGRDEADGAESAGFLSPGQTGGAAELVTFYQRFGDVGCWVFCDGHIQFNFPDHTKIVLDATGTWCHFWHLPQEAAQRLAATGTIGAAALDDRATLSYPLQTLLNFQSKPARASSASRRRPEIDASIQGIPAANDFRRKVGFVRDVVREWVANGGMGNSSTDREPRLRWKGFRETAPGALQKHVWVTIGARWGDSRLSTLVDPRRPGEDDFDYMEPWAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9X5</accession>
    <name>A0A367L9X5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tetraspanin Tsp3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_7641</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9X5"/>
    <dbReference type="STRING" id="1330021.A0A367L9X5"/>
    <dbReference type="OrthoDB" id="71600at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI11220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="32408" checksum="017664194BBBE654" modified="2018-11-07" version="1">MHTSCILCLQADMKRIIIIIIMIFDFIFTTTPSSKMPIWLLVHLLLVLLLLAIAIYEHVTSTSLSLPLRPSLTITTIILPILSAANAIFYQRFLLRSASAAARRRTLPRAMTLQALQAILTVVMATLFFSDMMPSVARTCLLSHRWQRLFSSRDVDSIRRIQDALNCCGFRTVLDRPWPFPGSQGARECADTYRRDVPCSQPWQMAMQRNCGVEFGLVIAIGFWQILSLILPLRTMSQSRTANDDDSRRRLLPDATAGDGPRREREQDDQNDASRDNQPNSSLLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9Y6</accession>
    <name>A0A367L9Y6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Methionine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="2">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Methionyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_7700</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="2"/>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9Y6"/>
    <dbReference type="STRING" id="1330021.A0A367L9Y6"/>
    <dbReference type="OrthoDB" id="24670at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.220.10:FF:000002">
        <property type="entry name" value="Methionine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023457">
        <property type="entry name" value="Met-tRNA_synth_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326">
        <property type="entry name" value="METHIONYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="11">
        <location>
            <begin position="641"/>
            <end position="815"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI11248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="836" mass="94809" checksum="5489E68EAFA746A1" modified="2018-11-07" version="1">MGRPVPHSLRQLSRPRWSCLADQKRIVSQRRWAIIKKAYFNPDKSYYITTPIFYVNDAPHIGHLYSMVLADALKRWQQLNGVTAFLSTGTDEHGLKVQKAAESLKVSPRELCDANSAKFEQLTLMADISADFFIRTTDEKHKRAVSKAYSHLRKNLSELLGLYEGTHEGWYSINDECFYGDQEVERAIEPQTGRKITISLETGSEVKWIKDKTWFFPMTEYKIRLLEFYQRNPRWITPKTKMDEVRNWVQKHLEDLAVTRPTSRLEWGIRDPHDDGQVIYVWLDALINYITNAGYGQKEPMDMALWPADLHVIGKDILRFHAIYWPAILMALDLPLPKRIVCHNHWTLGGRKMSKSVGNVVDPFLALQRWDKDTVRFFLLSKGSLKKDMDYSNRAIRVTYIKDLQASIGNALQRVCKPKTTHGWSVEESVRICTDPDFSPPAGNKGIFMTLHPILKKLAPTFTYELSRPDFQGAMGEISLALRELNRYISDTEPWRLALKQSDPSRPTSLFYTQRIDPEYKDRSLQWVIFNCVEALRIVGILLQPVMPTKAAQLLDDLGVSPDMRTAQYASFGKDSTYGKPRGQNVPDGVRIKKWDTLFPPLPDTEQWPDDIVPGKLKPALRQKTKNKMNQLAEVLACEAREAREEGEEEGAREEEILDATASEPLSLHEEFANQVSWHASADKLTFIICGTDGSPKGDVNVFLTEEAADAGEGEDRRTLVGEVDVMIARRDQRGLGLGSAAVAALMTYLVRHRLEMLVEYAAGGPSAGDLVGLKAKIKDGNRASRALFRRLGFAQVGEPDFFGEVTVVMGWADVVERVEGWLKGDEGAYREGTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAF1</accession>
    <name>A0A367LAF1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">nitric-oxide synthase (NADPH)</fullName>
            <ecNumber evidence="3">1.14.13.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_7145</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.39" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAF1"/>
    <dbReference type="STRING" id="1330021.A0A367LAF1"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004517">
        <property type="term" value="F:nitric-oxide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006809">
        <property type="term" value="P:nitric oxide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.340.10">
        <property type="entry name" value="Nitric Oxide Synthase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1230.10">
        <property type="entry name" value="Nitric Oxide Synthase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.440.10">
        <property type="entry name" value="Nitric Oxide Synthase,Heme Domain,Chain A domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050607">
        <property type="entry name" value="NOS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044943">
        <property type="entry name" value="NOS_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044940">
        <property type="entry name" value="NOS_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044944">
        <property type="entry name" value="NOS_dom_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004030">
        <property type="entry name" value="NOS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036119">
        <property type="entry name" value="NOS_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43410:SF1">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43410">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE OXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02898">
        <property type="entry name" value="NO_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56512">
        <property type="entry name" value="Nitric oxide (NO) synthase oxygenase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="10">
        <location>
            <begin position="483"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI11407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1021" mass="112836" checksum="85222FE181284578" modified="2018-11-07" version="1">MMPFSKPCPEEEFRRIKCHYAQLSSTGCTRSFCQGGRMVHTDEAKVGGERSSEVVEAEAIDFLRQLRRDGIIETDEALQKRSAAVLSQIRRTSVSAAAAGIWTPTADELEHGLRLSWKHARKCIMRSEHSYLKTHQRTIRLHDFRHVTTSEEMGQVLIDGMADAYNGGDIQPSVFVFPPKMPNRPGPMIWNQQFLSFAGYSQPDGTVLGDPATVGLTKAIMALGWTPPAVRTRWDLLPLVTMADGDEPFISHIPEHLFPLVHIKHPKHGLAFEKLGLRWVPAPALSQQAFDIGGVQYPATPFIGWFMDAEIGVRDLADTFRYNVLPSVASALGLLEHDVDELPQWERLAVLSRAQTELNYAVYWSFLKAGVRMSDSMSASAIWTNYDEQHLKENGFRLPADPYWLAPPQGSIIPVWHRGGAPNYQPKPMICRLKENPVKVWKRLKGLVPSVVEEEEEEKEQGKLCPFAGREKLAPQSRSGPIIRVFYCSSGTTAARLAIKLEKRLRMMIKGRDAEHQSVAPAAPLNDFQLDSLRAGDLVCIVASCAGRGDVPSNGEALLQMCLRSREAEVSGASFCMFGNGNSSYGANFNGAATKLETALQRAGLSTSLPLFRADTLKEDPPWRQFDSWLSLVETGYRGGSSNTTPIDAVPRGKALEARDNSTELLLPQLSPAAVISIYTPKGGDMTLLALDVGRLEYGHMSHVDIFMPLDEKEIDDLLLMACLTGDELLTFQTGQQITMRKLLSLVDPDRPFTSLSWAAGLGLQLSARDRDELLSLPIKKSLIRRLPIGWQCSAEPETLFDFVMSLPIRRSRTFSTASSQLYWSTQNMGNVLELALKRRSGGLITDKFVSQATRGRRLFVRVRHGPGAHLVSDDKPLVAFTIGSGIAPLRGLLQARCCIASESMTDQVGSPASLFLGFKPGDGDIINEATSEAAELGLVDILRQTPSNAARERAQDKVFDHPAEIVRKIRDEGANVFVCASKEAADEFAANIEAILGVRSIRQALGSRWIEEVYVYTEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAQ7</accession>
    <name>A0A367LAQ7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribosome maturation protein SDO1/SBDS N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAQ7"/>
    <dbReference type="STRING" id="1330021.A0A367LAQ7"/>
    <dbReference type="OrthoDB" id="2567806at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS N-terminal" evidence="1">
        <location>
            <begin position="8"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="114" mass="12893" checksum="74F6CADBEB615CE8" modified="2018-11-07" version="1">MTRGEATQTKVHYKGKNDDFLVFVDDSETYKKWKTDKSIPLAHFVSSFKIFLTHRQGAQGTYDAAPKSTLASEFDTEKEDEVITKILQNGSVQTVEMPSRQGVTNESMSSMRTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LB76</accession>
    <name>A0A367LB76_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_7632</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LB76"/>
    <dbReference type="STRING" id="1330021.A0A367LB76"/>
    <dbReference type="OrthoDB" id="5374328at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018287">
        <property type="entry name" value="Hap4_TF_heteromerisation"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF7">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10297">
        <property type="entry name" value="Hap4_Hap_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="4">
        <location>
            <begin position="93"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="59"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="178"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="284"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="359"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI11492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="560" mass="59203" checksum="58A63B3B3F1854A2" modified="2018-11-07" version="1">MASSPPSLLADSGHEAKDAPLASRAPLPNTKQRSAVAPAPLPRLCLQPVDKMAMSAVMAPDPAPNLSMTSKEWIIPPRPKPGRKPATDTPPTKRKAQNRAAQRAFRERRAARVCELEQQLDEQREAHEKHDAEMRDKMHGLELDLQSFRSRCLLLENMLERERQDRVRAEAQAEALRRQSAADSFSRAPLHQAGLQQHGHGRGPPSSHGKTLSISNIITPPDAVVGGRRHEEADMALGCGNCSVNGPCACADEMLASASSGCGRCGFGITCQCFEEVSNALGLKRPPSVSGPASSGKRPRPSDLSAASSQTLPSAYPTAPTESQMPSADSMPLKDRCGFCKEGTYCLCAEEAAQARAAETGMGSGAGSPTVDLSQQTETPPPSEPDVVAPPLVMEMTADGAVKLPARRSSNKKPLPATEAGGGCGSGGPGTCAQCRADPKSGLFCRLMAARLDREQGGCCGGRGADGQCCKSGSAREKITLPSLPSLGLSCAEAYQTLSSHRNFDRAADDMNSWLPKLKAAAAAGRGGDSEHRGRHAIEVEAASIMSVLKEFDVRFGRDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBH9</accession>
    <name>A0A367LBH9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase-like 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="2">Rotamase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_7146</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cyclophilin-type PPIase family. PPIL3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBH9"/>
    <dbReference type="STRING" id="1330021.A0A367LBH9"/>
    <dbReference type="OrthoDB" id="271386at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF2">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="6"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00029569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI11779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="396" mass="43686" checksum="BC185634D6D46938" modified="2018-11-07" version="1">MSVTLHTSLGDLKIEIFCESVPKTAENFLALCASGYYNGSPFHRLIPQFMSGTSIWSTAFDDEIRPSLTHASRGIVSMANKGPATNGSQFFITFDKAPHLDGLNTVFGRLIGDEALATLANIEAVAVDAKNRPKVPFCIDRVTIHANPLADSMPPTGFSSPSRVGGTSLGVCHGAVDIETYIQSAHLTLPFPTAATRDVEQPNRLPLATRTMSKDIYNNQKKKKSRAMQQIPSGSLLRPILATKDSQKTVPAAASAATFIIIDDCLDLLNCAAAFRVYIIFAPCTLCHPFQPLLILLLRHGCFFDIKRACRASRNRRRECEQEMQRRLNKVKEGEGETTTMTLPNLPRSMAIEVRLSCIMIGLASIHLLRMFSSATVYLLRLYRGVNNRQSRCKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBK5</accession>
    <name>A0A367LBK5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBK5"/>
    <dbReference type="OrthoDB" id="4908287at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI11809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="340" mass="38356" checksum="39A4FBA6381EDEC5" modified="2018-11-07" version="1">MIQIFGAWYSGLSKFGSTPAPSHTAQTAMLLATLLTICVVFGPRYGFGDDVYPGGEVFRVPDEEASWAHRIAQRMIALHTANHQHPSLYGTWASVVDVTRPPVLESSITESTCWRNWLSCGSVTFTRRTELINDPLPLPFASFLSHLPPVSYEPKARVFATRHQEFQKANHDNETVTLSIRQSTQELESTDNWQIAANLGHDGIIRLDKGEALRDRNLTSQVAERLDCPPKRTCTFETWTMHATFTGYCRRRPTIQCGDDAKEICFPINPGRYANELEGPLRIHEWGDCEQFNLFVWNNCYKQAADKFLGPIAEECEVTSPIFYEGRPLSAVVSRNTLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBL7</accession>
    <name>A0A367LBL7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TATA element modulatory factor 1 TATA binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_7375</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LBL7"/>
    <dbReference type="OrthoDB" id="74178at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052602">
        <property type="entry name" value="Growth_transcription_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022092">
        <property type="entry name" value="TMF_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022091">
        <property type="entry name" value="TMF_TATA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46515:SF1">
        <property type="entry name" value="TATA ELEMENT MODULATORY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46515">
        <property type="entry name" value="TATA ELEMENT MODULATORY FACTOR TMF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12329">
        <property type="entry name" value="TMF_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12325">
        <property type="entry name" value="TMF_TATA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TATA element modulatory factor 1 TATA binding" evidence="6">
        <location>
            <begin position="2541"/>
            <end position="2653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="153"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="363"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="678"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="737"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="871"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1309"/>
            <end position="1506"/>
        </location>
    </feature>
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    <sequence length="2656" mass="293554" checksum="89AFB1FD66E63DF7" modified="2018-11-07" version="1">MAAAQVLAIPPSCISNKPVWTKPRFLATRWDGLPLHAQLQIISRAWVDEVRSSKGFTITPAPRLRTVNSIRAPYGSSRLSYRSSTTLDVVENCEQITDPDDVIESTARQRLPACRFSAILLHPEAPMQKRSDAESGLFRDPAFDVTLDWEAQQVHERNGKKKKQNKHNPKKKRRQDGAEENEGGDGGDDDGHGQDGNGEGGDDAADGGGNAEPGDGGDDDKDKGKDANEIDAEEPMTGPPWADVTTGKKKKGKKGNADVEPTTNSGITDSGIDGETLQEIKLGDDRGTNDPKLCSTQNNNGVASWGSSWEHGMASGSWANAVGSGHIIKQGAGERKFDLDPNPWSTNSEKSKIKISTPFVFDAVDGDKDKANGGKADEKKSCSEWGWTLPRENGKRDSAKASPESEQILEQTEPTSPTFGVAPPEKVDNDGDNYWEEDWGKPVKDKTKKKHDASVSDPAPAAAPEPAANDLLATATIKRGKKSKNKATYPQLYATTDEVLGSASDPKPEPEKDKVDEYDAKPFKKDKKKKTTMPCDEPKRAQDASRTTPDVSGYSAQEDDAVQWPASYEGRGADTESNHPSEPQNDNTNTTAADTARSNSLETTSKKGNKKKKRALLEGDAKQFPLLNPKSDTILDDISQFPSAGDKKDMKKVSTTDDSRECEKKFSDVMDFNEQDSTVSVDISGNGDFVASKDKDKEACGEGSWKPDDIEEPADQSSAEFSGKRVKKGLVDVVEVNKGNFDPPTWGMFPTPEGDEQKSNKDKLNGEAKNEKLLKLSAKEMRKLEKEKKKAGKVRIDQAIDEAEEPEAEEKPLSKAEEKTDEERVRLEAEAAEIAQEEEELAALKRKKFKKGKLPKKDKERFDVLTAIAARRAETMSSRDETEEAVREAEDKAAQEAQEQAVQEAEDKAAQEAQEKADREAEVAQEKAELAILNKRLQDKGRLSKKDRDRFNLLTANAARREEDLSFNKAEGESAQEEEQKAAREAEAKAVREAEEKADQEADEKADREAKRLLDNGRLPKKDRDRLNLLTANAARRGEDLSFNDAEGESAQEEEQKAAREAEAKADRDRLNLLTANAARRGEDLSFNDAEGESAQEEEQKAAREAEAKAVREAEEKAAQEAKEKADQEMRRAEEKATRKTEKAARRAEEKAAREAEEKAAREAEEKAAREAEEKAAREAEEAEAAKKAKKNSKLKDKEKGKREKKPKEPVPAEADDVDAAKVSSEPELTSDQVEELLSPRDQQANDAFNFWGVGGNTKKPKKAITGKVSTLAFIQKVDVSVAATARKPVKGKIADKLKNFELAQDDALIDVPLLAPSPKDDDKSFKFRSKGKDVGTAEQDSFFSKKSHQSSEERTKIKDDGASWARWNASPPKEKRPASRSKPDKSLSSKSLEKSSAKDSGSDKDRAERVETADQTPSRVRTSAASGTPPILSRSTSTREREREKERRPTANTKNSRRNSVDIAHGLASPPTVEAPVMTPKASKVLGVDKSSTKRRQRKEALVEDDDIVMVRAVDADADVDALKREKRRSKRSQDDDIVVVDSGGPSEMPAKRSAPPVKKSGLAGLFSGLMTPRSARTEARLDGDNAGRTPARKGRRNEHDSADKTSDESRRHKDEARRSSRRKREHEEDVRRHEAKEARRAEKRAIRPRGEEHTARRADRHRHREREAAAAAAAQRDEAAARQERRPSQMDSPAEDAERRRRREARRAGRAADDGGDVHWQKGSRRHREPLAEEHAYGHKNRAHVWPNSGPSSWMRDHSDAAPPAEDEERSRREARRARRRAKYGHERGADEGDDRSRRRRQQQQREGGRSGGKLAYMDERLAFSRAHRFDAPLFLHQRFISFTTIMSAPAPGGKPSRWGSLLSQAVAGVESRLDVMLAEADDEAQVAARSKPAAPANPSPANLRSNSSSARANDRLQARLAKAVAAKSTSASTDGLESASPRGSIDTASRPSTPFITEPGASAPSEPRAQSSPVRPEQPPLTSPPDHLLAGDAASEQPLAPFDHAGDDTQPARRQTKEFEDIKLLHQDEIREYVEQIDSLQSKVQYLSRNVAESAKKAASSAVSGSMERKLAEKDEKIALLMEEGQKLSSAEQKFRATIKKLRLQLTENERQTAELRKDKEKAASEAASLRSRHNGTEQPEEAWKAAATLQREISSLRKANAARDEECRRLEQEVKLKEEQAEAIRAEASSKAEAVEGQRQREFQDAIAALQAEKESLVSKARREGTEWREKLERAAERSRLTEEELGLELRSMESKLETMRAAAEEASSRSGGEAQVNMFRQIEMLQSQYASARENWQGIESSLLAKAANLERERDDAQRRESDMRKKARDAASHCRRMEDELQDVQTALAASRLELEACRDQVTVLKSSARAAEEALQQAQADLENERQRTVNRDREDAVEAERRRWVEDVAGATSKGGHQSRPNSPLLPASRTFSSELVGLPTPSKLRRIPTPAGSIPDTSAELVPPIRRLSSQPPPKHNALPTLTSGPPPVPFSPFEPPSDVLHVPSPTIERENGVDDTAPSSPRHLAHDMISASTVAAGPSVQLVERMSAAIRRLEAEKVAAKEEMARVCNQRDEARADMVTIIKELEEAKTAAKRVPQLEADVASLDSRYQTTLEMLGEKSELVEELRADVQDVKAMYRELVERTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBN8</accession>
    <name>A0A367LBN8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7306</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBN8"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI11826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="72" mass="8184" checksum="518B09FCD3AFB82D" modified="2018-11-07" version="1">MLAISSALLASLPRSLDLRNPEDEVAALRISYEILLDILDILFSAILEGERLTFNRLEEIRLRIIETLSDTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LC09</accession>
    <name>A0A367LC09_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="3 6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_4623</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3 6"/>
    <dbReference type="EMBL" id="LKCN02000008">
        <property type="protein sequence ID" value="RCI11960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1330021.A0A367LC09"/>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000006">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044609">
        <property type="entry name" value="FKBP2/11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45779:SF7">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0697">Rotamase</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017082659" description="peptidylprolyl isomerase" evidence="7">
        <location>
            <begin position="21"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="8">
        <location>
            <begin position="41"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI11960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="177" mass="18773" checksum="BC03584A0FF0FBD5" modified="2018-11-07" version="1">MKTTPFLAAFAAVYAGLVGAAEQLQIDVTLPVECDRKTKNGDSISMHYRGTLKSSGNQFDASYDRNQPLTFTLGSGQVIKGWDQGLLDMCIGEKRTLTIPPALGYGQRAMGPIPAGSTLVFETELMAIAGVPKPEKIQTKATGEAIADKAGSAASDATEAVKTMMMDTDDTQGHEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LC60</accession>
    <name>A0A367LC60_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_1072</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LC60"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI12010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="355" mass="39685" checksum="56F54A8AEC79CE85" modified="2018-11-07" version="1">MHACMNADFKRALDRASLSAPYVMIHRYPAYGRLVITLPLPCHPASESETPLKIRALQPTASSFRARALSPFHLSEDLYYAGYKSIFIGRQEKGGGGGKGGPPAITAFTDGRIEDIDPNRSPSPHFPSLFSPSLSSNIHLYPYVRIRIMIRDDIFALPYSLRIWAVIFFQKNPFSPACSLSTEPVCSFLTGSRIVWCHYLDNPPPLLLSPPWLAVIMPPSEANQAGKSFGVSNGDLGKTCNTCLLACATLVRLNKKTLDVVVRRIVSYRIVSYRIASHPHYPCCLCYPPTVTRSPAGDEIPYGYSTHYWDFRIRGFFLVVAVFVIRYGEVHLLELGWTVSKSRKFISFGSRESVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LC61</accession>
    <name>A0A367LC61_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Apurinic-apyrimidinic endonuclease 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_7377</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AP endonuclease 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LC61"/>
    <dbReference type="STRING" id="1330021.A0A367LC61"/>
    <dbReference type="OrthoDB" id="7663182at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00019">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.150:FF:000001">
        <property type="entry name" value="Probable endonuclease 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00152">
        <property type="entry name" value="Nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018246">
        <property type="entry name" value="AP_endonuc_F2_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00587">
        <property type="entry name" value="nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002199">
        <property type="entry name" value="PRK01060.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445:SF0">
        <property type="entry name" value="APURINIC-APYRIMIDINIC ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="ENDONUCLEASE IV ENDODEOXYRIBONUCLEASE IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00730">
        <property type="entry name" value="AP_NUCLEASE_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51432">
        <property type="entry name" value="AP_NUCLEASE_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="10">
        <location>
            <begin position="95"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="383"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="383"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="429"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI11822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="440" mass="47740" checksum="9B9D20E57C54566E" modified="2018-11-07" version="1">MTRSLRKKTAPSRSAAPVPSDIAPQAVTSKRKEAQNPVESDEEATRRPVKRTKTKAQRDENMALSERTAVSSLGKAMYLGAHVSAAGGVHNSVTNAVQIGANAFALFLKSQRKWSSPPITTEARDLFAASCKNHGYSASQHALPHGSYLVNLAQADEAKAAQAYGSFIDDLERCEQLGIKLYNFHPGSTLGDARPAAIARIASQLNKSHKATKTVVTVLENMAGSGNIIGSTWEDLRDIIALIEDKERVGVCIDTCHAFAAGYDMRTPGAFKATMKSFNDVVGVKYLKALHLNDSKAPFSSNRDLHANIGTGFLGLRAFHNIMNDGTFANMPLVLETPIDSKGPNGKTSEDRQIWADEIKLLESLIGMDPESDEFKARELELQARGATERSRIQDQVDKKSAKEAKKGGKTATGKKTQKRGRKKKAEETSESDGEDLQST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LC75</accession>
    <name>A0A367LC75_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_1240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LC75"/>
    <dbReference type="STRING" id="1330021.A0A367LC75"/>
    <dbReference type="OrthoDB" id="4330117at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="13"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="328"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="406"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="591"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="149"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="332"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="354"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="414"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="434"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="594"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI12029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="663" mass="74896" checksum="348F1EF1A4381E1B" modified="2018-11-07" version="1">MAMTMADNVIRKACDRCHLQKLCCKRVADEACERCVRLRAECKSSPSLRYKKHNHQQHPRQQQQQQQQQQQQQQHPQLQLQLQQQQQQPPPATAPPPPPPPPPPPPSPPPPPAAAAPAQPVSLNQLQLRQQHQQQQQQHHQQHHHHHQQQQQQQQQQQQQQQDQQDQQQLQSQPLQPQHTNNPPEEQPIQNQQQLQHAQSNQPLPTVGPQTIVLSRRSPKRRKTESEPNSEANQAGSLTPQNEELGTTKHGLALESGDFGLSFAEIAFLTPPHPDHHHLSVIPDSFHSPFPEPWETQLGPSNPEASYQHINSYATVVPSFQQTTSVVVAPPTGRPPQPPPPPPPEIPPAERVVRRQRFKQRRPRQIQLRQVAQPPAQRGEAPTVHWMAQLSDINKRLLELASMLPQPQQRQHCNNNNSSNSNNGNGNGNGNGNGNNNNNNNNINNNNTNTNTNTNNNGWSADEAHDFPIDEMFKLTRKVADILDGLSRSGPGSADYLDGSDPGNSMFVLSTYVRLLDMYQRVFYLVRDEVVRARSEAAFGFWKLPDVTVGSFAVESMPSLQMSLTIQLAEEFLNRLRGATLALDPALRKDEDRHHHHHHHHHHHHHHRHHHHQTGGVGGNGTDGDSMFSDVVDVSYRAVRDKEESLARHLTELRDDIEALLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCY5</accession>
    <name>A0A367LCY5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_0886</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCY5"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI12092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="61" mass="6926" checksum="6420D9655C02A755" modified="2018-11-07" version="1">MRAEPTRRVNKENFTAVVPHTGIHKAVDNNRRRLIETSGHWDCPAYVCCRRNKGEPIPGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LD97</accession>
    <name>A0A367LD97_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LD97"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="95" mass="10656" checksum="95C3F75EC6EEC9B3" modified="2018-11-07" version="1">MHKDDSPPSTIASLKSEQEVARSPRCRTLAPMPLYAQRSWKDGHCRDTSNQTKNAQSSSRYPPFVHSPFVMFDSDDDMADRTIDEIAAEAINISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LE20</accession>
    <name>A0A367LE20_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_0879</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LE20"/>
    <dbReference type="OrthoDB" id="4921558at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI12675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="373" mass="41888" checksum="3D75CD53CC4691D2" modified="2018-11-07" version="1">MEDLPSFPTVRIRDKTLDVIDSFARLPSSFIMFSSLGPWLKLVAALSHQTIQPVLSVSTTDTKEGISGNAYASNRWRSTFYTEIVDDQGPPSRIIPIIERKPDFPVRAVREGTDVHTPHGESWVLEPARKGDWKATSPPRIGGYDNIRTGPASIGPVKKSLFGTLCRFPSILMFRTFHHGRPMFNIYVTEHGEPELLVSGLFSCGLIGPQDIVDTCRIPNHRCVKESGSLIDVRPGFYSGRSASFDQIPIAACDEFRLGPPSAKHNLVCTRIETYQGSKYTHIYWCMMRTEYKATDCIWHNVARKSWPSSGNGLGRIIQPWGKYYVMFFFSETEKAGYLHIQLQRRNESVGPPEDVDDLRNCLGPSYAILVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEB9</accession>
    <name>A0A367LEB9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEB9"/>
    <dbReference type="OrthoDB" id="5305418at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035186">
        <property type="entry name" value="DUF5308"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17233">
        <property type="entry name" value="DUF5308"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="200" mass="21619" checksum="8929956D1F0E06D8" modified="2018-11-07" version="1">MANLPSQHPSLAIHLSDLTLTPLISSSSNLESLTSLASSAIASHTSAHRAHLGRPQRIMVEYPDRGPVLLHTYLDPRDAALPSYNPDASSSSSSSPSSPSSYSSYFPDEPAAAVIPKLGRSNLKEGRNHKNDGEADVRRDNHANDSRAEEPAPFLVGLVVAASPDDAAEARRAATRLERVGRDFQREWIAAERSFDSRPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEW7</accession>
    <name>A0A367LEW7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">Structure-specific endonuclease subunit SLX4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="primary">SLX4</name>
        <name evidence="18" type="ORF">L249_0488</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Regulatory subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="15">Forms a heterodimer with SLX1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="15">Phosphorylated in response to DNA damage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the SLX4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEW7"/>
    <dbReference type="STRING" id="1330021.A0A367LEW7"/>
    <dbReference type="OrthoDB" id="5349119at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033557">
        <property type="term" value="C:Slx1-Slx4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18870">
        <property type="entry name" value="NUDIX_AcylCoAdiphos_Nudt19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03110">
        <property type="entry name" value="Endonuc_su_Slx4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039121">
        <property type="entry name" value="NUDT19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027784">
        <property type="entry name" value="Slx4_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018574">
        <property type="entry name" value="Structure-sp_endonuc_su_Slx4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12318:SF0">
        <property type="entry name" value="ACYL-COENZYME A DIPHOSPHATASE NUDT19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12318">
        <property type="entry name" value="TESTOSTERONE-REGULATED PROTEIN RP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09494">
        <property type="entry name" value="Slx4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 15" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 15" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="17">
        <location>
            <begin position="920"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="20"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="258"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="316"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="502"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="588"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="320"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="341"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="622"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="753"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="780"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RCI12969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1197" mass="130702" checksum="2DD95F82CEB81C46" modified="2018-11-07" version="1">MASPDVFLTSSPRARRQALNIGASSSPGLPSVQDILSQKPSRPPLLNAPFPKEATPTTVSACRPWRSLETEQSSGKAMEDIDTSFSVMEVPPESFKKGEKVRRRKKAGPARPKTPCEQTTSGDLPADQPWKKYKSPKRSAESAIDSRPLAEARLCPERSSDADKGDGSRYFIKPGEAQKQKVTRPSKKVTDEPLNLEAAMERRTEWTPPTQRVRIILDSDDTPPSDVNATRPSQVDDGQVDSFETVVASFKCETTQIQAGSNPADDGRGFPHKRRLLELIPTNTRTTSEPSKRQKAPKKKTRTLTDIATRAYRPATQRDIVADERRASTTATKDETGKGMTKARKRPSKASKKKEAPPKPILLSPEAALRQVAHQDFLFGTSSQLAREQSPLPRSHTTTKDLDMIDLRTPINSDAIEPAEQRPTLWDAGARDEDGDLFDVEVGLLADGPPELAEAVTEADPFGYVPVTVSLPSLINSDDARRESSVGLPDVVALRSGEPMTSAGYESVASGDDQGAALADGKPAAKRRRTATTTEGGKDEKYAQETRAEARYELFTDGQLAKQVAQYGFKPIKKRAAMIALLKRCNPGVGATLGGPSGSRSASTFEKKKKGGAGQSKAVSVSDDDDDDDDEGQKPIKGKRRRGQVKSGNAGDAVANKVVTKKRSQNRTGAAASIADDEAHTKEKKRRKSQSTAGIISDEELDWFLMPRRCRSRSKAGSDSDAESSEAAVDNKKRGRRKKKAVDEPPASAQRSRSPRRKQRSRSKRGAKESRRRSPREIADSQSDSSDGSSGSSSSSSRFDLGEDETMTSSLSPTEQQKELFAHISKAVTTAPRTTSPKQPSWHDKMLLYDPIVLEDLTAWLNSGQLTRVGCDEEASAAEVKAWCESKSICCVWRMSLHGKDLRGYMSLTYLCRLSRDAERLRASASVMVLSPRNEVLMVRRAPTSSSFASAHVFPGGQLDEFHDGAVPSPDAPGRHRDGPAYRLAAVRECFEETGVLLASGRGADAMRLSSPERDEARRAVQAGEVRFGTWLERIDAVADTDGLIPMTRWITPAAMPRRFTTQMYIYPMPEEDAMPVPTTDGADGENTAAEFWPVRSVLEAAAKGSITILPPQHYLLHRLASHGDKERHEPDDKVICPRPIGVLPDKRTVLALDAPGPELRGSGREGDRETVLVVEFAPGGPRVLEVRSRRDVTALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LF68</accession>
    <name>A0A367LF68_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_1119</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LF68"/>
    <dbReference type="STRING" id="1330021.A0A367LF68"/>
    <dbReference type="OrthoDB" id="5370830at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38850">
        <property type="entry name" value="CERATO-PLATANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38850:SF2">
        <property type="entry name" value="CERATO-PLATANIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016594782" evidence="2">
        <location>
            <begin position="22"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI13069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="535" mass="56113" checksum="C3C2303E67A49BD9" modified="2018-11-07" version="1">MLAFVLSSVLVASGAFIPAGAFPCNNCVHDALAPLNVTHNIALKNCTRVPPVSDHKAVAVNELSEPKAVADPENRSKEEQSLAKEFPSGAARGKKKCGKSPVESQAPVESSPAQPSPQDVAGPQGQPSGDDAAGSQEKPQGPPKQQSPAGPPRKKCKKRPFQESQPPMEPQKKPLSPSEKEPQVKPVRKPCKPAPKQSKSSANNGEQQLVTQPSNNGDGVKPDEGRIEPPKTDNPPAETAQKPEESPVDANGINSNDKAEIAGEQLPTASQEPSPQGPADQGEQPADVPGEPATKPGEPAKKPENPAKEPEPSVKEPEAPAKEPGKPSGKPGSSQGRPGGNITATSHVEYSSSIGVLGCKGVDLSRIAYFPGTPGCDDICVKVTYEGRSVNLLRIDNSGSAPSPDNSGTFDMSCQAYDFLLHGTDNKKSCQTGGRTAMSYETVDPDECKHLLSDGVLPISAPNPNYYVQCANHPTFNQGSLKLALFNINDARCKYGIDEECSCSGVGDPKCRSGLGQGNTRQLQGLEVVDPSYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LF84</accession>
    <name>A0A367LF84_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_0442</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LF84"/>
    <dbReference type="STRING" id="1330021.A0A367LF84"/>
    <dbReference type="OrthoDB" id="5550281at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="135"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="1">
        <location>
            <begin position="135"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="249"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="256"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI13085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="332" mass="37100" checksum="D833F29564156FEA" modified="2018-11-07" version="1">MPRPQPRKADDKAKVPVAAAQVPTMTAPQPAVMPVPVAAHVPMPTRVVDIESFMRVRDSAVGRLSTIMELLRSFTADYIRQTNLLMGEPTAEGQGDLLSSFENAAAQLIIPMPEMAVPVEEKKERKKRTHDPNAPKRPLTPYFLYMQNARSVIAQDLGENSPKGAVQEEGQRRWAHMKPQDKKDWNGAYQYNLRLYNARVLSYKAGNLLAKNMTDDEARKYADECGLPVPEDFQEVFNPVPVDEQQAISDQIQQLQDDDDQHQLPVEEDDSSSLKKSSGSRKRKTATPTVESTEPVKGTPVSPDKKRRRASGKAAEEKEEPKKSGRKKTKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFR4</accession>
    <name>A0A367LFR4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sterol 3-beta-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.173</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Autophagy-related protein 26</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">L249_0618</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a sterol + UDP-alpha-D-glucose = a sterol 3-beta-D-glucoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22724"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15889"/>
            <dbReference type="ChEBI" id="CHEBI:37424"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.173"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:22725"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ergosterol + UDP-alpha-D-glucose = ergosteryl 3-beta-D-glucoside + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61836"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16933"/>
            <dbReference type="ChEBI" id="CHEBI:52973"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:61837"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Preautophagosomal structure membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.173" evidence="4"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LFR4"/>
    <dbReference type="OrthoDB" id="10261837at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016906">
        <property type="term" value="F:sterol 3-beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13215">
        <property type="entry name" value="PH-GRAM1_AGT26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13216">
        <property type="entry name" value="PH-GRAM2_AGT26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000303">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000560">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000029">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000009">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048066">
        <property type="entry name" value="ATG26_PH_GRAM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048065">
        <property type="entry name" value="ATG26_PH_GRAM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF25">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0072">Autophagy</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PH" evidence="18">
        <location>
            <begin position="288"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="75"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="467"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="705"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1355"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="851"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="484"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="514"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="563"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="603"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="629"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="644"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="706"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="717"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="1359"/>
            <end position="1380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RCI13258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1406" mass="157791" checksum="151897179D892E48" modified="2018-11-07" version="1">MACLVPAGDGAQSSSSQGRRRHEPYAAAVEMPEPLKESDSDDEPSPRDTARAQARRGLTINMHQSILGLIAAAGSRVDFNERFDDPSSDDDDDDDDAEDADDDADAAHRHHRPDPSRDLTQTAFLDPSAPRRGWEKKTHNHRLLKSLSTVSGLRGRPSRPSSSPRDIDDVQEDDPNEPTYPIPSVVLDGQDNCLAPVMSRMLQARADMSSRPSFDLDHASFDPSRSDGADNATPLAKRLKDMFGFEDYEQVIKEYPCWLLQCVLLQGFLYITSKHICFYAYLPKKDNVIVKSGYLSKSGKRNPKYNRYWFRLKGDVLSYYRDSNNLYFPHGQIDLRFGISAALVEGGKESLHFTVVTSHRTYNFKADSAPSAKEWVKSLQRVIFRSHNDGDSVKISLPIDNIIDVEETQMMEFSDTCKIRVIDNDETYAIDEYFFSFFSFGEEAINVLKTTIEDASSFGKQAAVKAASERQQGRANVDFPNSLLHEKRGDDPVRTARYSEPVRATLAPMPLTYGSSRTSCEGSSSRTSLETGRRCSSASRGRSRSRSFSAGRRPREKSPRNALESSESNLMLSTDDPSYSNLAPPNHDDPSASQILRGSDVFRSPTMRRSSSTSPPVNAEGGAPREEQQQQQKLQATEAADQADASQRPLTPSLQSLTKMGSYPLQRAGAFADYLNKTGKRVSSLFASESMGYVEKVSGMWKGGRKHYDEPTGLRPDEEDLEEDSEDKVQTSMERFRAHFALPESERLQATYFGYILRVLPLYGKIYISDRSFCFRSLLPGTRTKLILPLRDMETAHKEKGFRFGYSGLVVVIRGHEELFFEFSQAEVRDDCAVTLLQGLDTSRYLRESGLLRLEEREEREEQDLAEAERDALRSARQSEFPEHEVRLPQQTASLANAPTILSDDTDGSMICFKPQRSMRITCLTIGSRGDVQPYIALCKGLMAEGHQTRIATHGEFKGWIESHGIEFAHIDGDPAELMRLCIENGTFTLAFLRVANATFRGWLDQLLESAYTACQGSDLLIESPSAMAGIHIAEKMGIPYFRAFTMPWTRTRAYPHAFIMPDHKMGGAYNYLTYVMFDTVLWKTTSHQVNRWRNKTLGLPNTSLEKMQPNKVPFLYNFSPNVVAPPLDFSDWIRVTGYWFLDEGGDYEPPEDLARFIRQAREDGKKLVYVGFGSIIVGNPAKMTQEVIDAVRKADVRCVLSKGWSDRITTGARAEETAKVEGEPEMPAEIYVIKSAPHDWLFRQMDAAAHHGGSGTTGASLRAGIPTIIRPFFGDQYFFASRVEDLGVGVWVKKWGTNSFGRALWEATRNERMIVKARVLGEQIRMERGVERAIQNIYRDLEYATSLVKCKAGKNAEAEEDDDETEESWTFIGEDEPDPDMMTKRLSEGLVGDKSLGSQVLRGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFV2</accession>
    <name>A0A367LFV2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase II transcription factor B subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">RNA polymerase II transcription factor B 38 kDa subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">RNA polymerase II transcription factor B p38 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_0639</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFV2"/>
    <dbReference type="STRING" id="1330021.A0A367LFV2"/>
    <dbReference type="OrthoDB" id="5963at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061575">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16573">
        <property type="entry name" value="RING-HC_TFB3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004575">
        <property type="entry name" value="MAT1/Tfb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015877">
        <property type="entry name" value="MAT1_centre"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00570">
        <property type="entry name" value="cdk7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12683">
        <property type="entry name" value="CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12683:SF13">
        <property type="entry name" value="CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06391">
        <property type="entry name" value="MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17121">
        <property type="entry name" value="zf-C3HC4_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="19"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="133"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI13314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="354" mass="39727" checksum="1C5FF53D800D95AB" modified="2018-11-07" version="1">MSRSESLSTIRQADEDETCPVCKTTRYFNKDMEFRINSECYHRMCKTCVERIFKDGPNQCPYAGCHKTLRLRGFKAAFFADLSVEREVDIRRRVAAVFNKVEDDFENLDGYNDYLYMVECLTDDLVSGTNEARARAESQLSDWEAKHKAEIERNRRLARESDEARNRRIAAENEAAKQRRLQNLREEADERASEARFRKEMLDSLQSADVGHAAQAVDKILLKKRGQQRRQAAAAAAAANPSGLSIRGLRDKTKAAVDDGPYDPFAGLNLTPTRVDLSAERLRDYHSEWVDVIRSKDEYLVGGYGADEYISRALFEAFSGLAVFIADEPAPAGTATTTTTAAAAVTKPDTPQAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LG07</accession>
    <name>A0A367LG07_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoserine phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">O-phosphoserine phosphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_0864</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HAD-like hydrolase superfamily. SerB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.3" evidence="4"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LG07"/>
    <dbReference type="STRING" id="1330021.A0A367LG07"/>
    <dbReference type="OrthoDB" id="27226at2759"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00198"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036424">
        <property type="term" value="F:L-phosphoserine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07500">
        <property type="entry name" value="HAD_PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000143">
        <property type="entry name" value="Phosphoserine phosphatase serb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050582">
        <property type="entry name" value="HAD-like_SerB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004469">
        <property type="entry name" value="PSP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01488">
        <property type="entry name" value="HAD-SF-IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00338">
        <property type="entry name" value="serB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43344:SF2">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12710">
        <property type="entry name" value="HAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01137">
        <property type="entry name" value="C1.6.1:_Phosphoserine_Phosphat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01136">
        <property type="entry name" value="C1.6:_Phosphoserine_Phosphatas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00029">
        <property type="entry name" value="phosphoserine_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR604469-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI13356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="447" mass="49028" checksum="3CC861246CA98D78" modified="2018-11-07" version="1">MADAARKRPQLAASTRKSSYLSDLQQYRPPKPAHSGIDAVVADARPEYPSATATAFNGIPSDDNPPTIVESGLSHALSHASCAPAPGRQTDRLVATLFYKRSEPTDVAPADSIDDFPLEPPSAVEAEQLDHLYGSYVSPLCVASFLHLMSTFPQPRDDCDAPHSSHRCLDSQHHPRVVEITLGPAPEPHYLGLDDLRRHEAIYRFEREWNVDVALQRDLVWRRHPRLVVFDMDSTLITQEVIELLAAAVEEPPDLAARVARITERAMRGELDFDASFRERLALLKGLDASVFDDLRPVLNLTPGAADLIRALKRLGVKTAVLSGGFQPLTEWLARELGIDYAYANRVRAVDGKLTGDVEGTIVGKERKRDLLVEIATKESIDLAQVVAVGDGANDLLMLEKAGLGVAWNAKPRVQLEADARLNGDSLLDLLFLFGFTGEEVGMLVSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGH3</accession>
    <name>A0A367LGH3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Inosine triphosphate pyrophosphatase</fullName>
            <shortName evidence="13">ITPase</shortName>
            <shortName evidence="13">Inosine triphosphatase</shortName>
            <ecNumber evidence="13">3.6.1.66</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Non-canonical purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Non-standard purine NTP pyrophosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Nucleoside-triphosphate diphosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Nucleoside-triphosphate pyrophosphatase</fullName>
            <shortName evidence="13">NTPase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">XTP/dITP diphosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L249_5530</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ITP + H2O = IMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:29400"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(6)-hydroxy-dATP + H2O = N(6)-hydroxy-dAMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:83971"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:233529"/>
            <dbReference type="ChEBI" id="CHEBI:233530"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:83972"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>XTP + H2O = XMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28610"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:61314"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:28343"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="13">Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 13 14">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="13"/>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGH3"/>
    <dbReference type="STRING" id="1330021.A0A367LGH3"/>
    <dbReference type="OrthoDB" id="6288734at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035870">
        <property type="term" value="F:dITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036222">
        <property type="term" value="F:XTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009204">
        <property type="term" value="P:deoxyribonucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.950.10:FF:000003">
        <property type="entry name" value="Inosine triphosphate pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03148">
        <property type="entry name" value="HAM1_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027502">
        <property type="entry name" value="ITPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="RdgB/HAM1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00042">
        <property type="entry name" value="RdgB/HAM1 family non-canonical purine NTP pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067:SF9">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE/HAM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 13" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 13" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="4 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="9"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="49"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="65"/>
            <end position="66"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="141"/>
            <end position="144"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="167"/>
            <end position="168"/>
        </location>
        <ligand>
            <name>ITP</name>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00093218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00093255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00093271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCI13518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="192" mass="21021" checksum="6C57DB7944D89F63" modified="2018-11-07" version="1">MRPIVTFVTGNANKLREVKAILEPSIQVESKSLDIDEIQGSIDEITEYKCRRAAELLNGPVLVEDTALCFAALGSLPGPYIKHFLTTIGHDGLNNLVAAYADKSAEAVCTFGYSAGPNQKPILFQGRCPGTIVPPRGPARFGWDPVFEYQGQTFAEMDASEKNSISHRARALEMLKNWFLDHSAHLDATTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGV0</accession>
    <name>A0A367LGV0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGV0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="75" mass="7944" checksum="E1123D0CD1115908" modified="2018-11-07" version="1" fragment="single">RLRRHFSGSARHSYTHIQGTRPEGLGGLRNAGPAAAGPRPPYVIAAIRGGYGYSTATPYSGYGRTGRTGRIKEGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGW9</accession>
    <name>A0A367LGW9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5515</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGW9"/>
    <dbReference type="STRING" id="1330021.A0A367LGW9"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI13637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="138" mass="16009" checksum="53D9BB6B4FA4B8C4" modified="2018-11-07" version="1" fragment="single">TRYKDIRTFSRKKGEFSAFLTNLKDKIRTDKATFRDEEDRIGFLFRSLEGKACKTLETRYDSIERPFSRLAEIIYLLTKTKDDSLSYEDFCGYVKDSAVKRLDAKLVLPNDFPALAKYSLSILLPKTPLLNRQIDPAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LH45</accession>
    <name>A0A367LH45_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_8026</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LH45"/>
    <dbReference type="STRING" id="1330021.A0A367LH45"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016669719" evidence="4">
        <location>
            <begin position="17"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="178"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="598"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="24"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI13745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="700" mass="78589" checksum="0738A7CB274C99C4" modified="2018-11-07" version="1">MVHLGLPVLLCSVTVAEDPIRSGVMRPVPTRLGRVVSERGRESESESEPYPMPRPQEREQRRNKKKKTTTTTTTTTKTKKKEEGKNRRTNKEMPVSSPWRDISIPDVDAWTYFMDSPRPYPDDHQEEDDDDDDDDDEDEEEGRGKNRRTNKEMPVSSPWRDISIPDVDAWTYFMDSPRPYPDDHPLFVDTTSSRSYTFAQVKDLAQCFGIGLRQRLSWSQGDMLAVYAPNDIDTPVVNLGVLWAGGVVTPANPAYTADDLARQLRDSGARALVTHTDVLDKALEAATAVGLSSSCIFLLGHVPLEKRRGLQLWSELTPTGTWFRPERTEIEPGRHLAFLVYSSGTTGLPKGVMLSHSNVVANSLQTHKADTGHLQWDIDRQLGVLPFFHVYGLAVVINTTLVTGATCHVMPRFDIVETCRLIQELSITFLFVPPPIVLQLSRHPCVKDYDLSTLRFINSGAAPLSRELVIDVWKRLAVGVKQGYGLSEASPVTNAQLIDEWWRFQGSVGRLVPNMKAKIVDPDGKELPPNQSGELLFKGPNVFRGYWKRPGLNSETFTPDGWYRTGDVAHICPKGYFYITDRIKELIKYNGFQVPPAELENKLLGHKDIADVGVVGVWDAEKYTEIPRAYVVPTSGVEASDALARNIVAWLEERVASHKRLRGGVRFIDEIPKAQSGKILRRVLKDMARKEGEEGPRAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHK7</accession>
    <name>A0A367LHK7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_8173</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHK7"/>
    <dbReference type="STRING" id="1330021.A0A367LHK7"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF13">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="310"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="342"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="90"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="196"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="460"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="220"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="461"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="476"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI13732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="645" mass="69706" checksum="7D9F7F13B2F835DB" modified="2018-11-07" version="1">MTAIGEQQPFHVFAHQHDQYPEPPRHAFASPPLGMGMCAEAAGFGAGAGLSRGREMYPTTTPAPAMGGFDPASLYGDAYVLGRASPGSYREDGDMRLPSSGLSTASAPSAPSSAMGSPQSNHGQLSAAAEWTTTPGGLAVQPSIVGNDYMAGAEYFSGASIDDLGGFDFTTVGHTAKTFVDPSLIHPDIVRPPMAISPYDGHYQPTNNPFAPSSVSSSSPQPNLLRTNSSSPYLHGGGSFQPAFAASPYGAPIDAAARRLSMGNFVSPSSAEYHSGDEAKEKQRCTYPDCGKVFKDLKAHMLTHQNERPEKCPIHTCEYHVKGFARKYDKNRHTLTHYKGTMVCGFCPGSGSPAEKSFNRADVFKRHLTAVHGVEQTPPNSRKKTPTGVAMGPGKKLTGYAPDATGKCSTCSQTFANAQDFYEHLDDCVLRIVQQEDPAEAINAQRLAEVDNDKSVHQTLEKNNLPSATPTSNMNDDYDEDADDLDMADDDEADDASSKANSSPSSRRRMNPPNGVVKSRGLTHSRGGVPLANKTRGRKNRRDYPSSWGFDKGQMTMKKRIMAVFDGSRRLAKDDMMLSTDHEVRLKLSDGKSYVTDLDVQTLKRAEGFHGATDEEKGPWLSDDPTEEQLKEMREMLQTGVAPLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHL3</accession>
    <name>A0A367LHL3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_8198</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHL3"/>
    <dbReference type="STRING" id="1330021.A0A367LHL3"/>
    <dbReference type="OrthoDB" id="18453at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13952">
        <property type="entry name" value="7tm_classB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017452">
        <property type="entry name" value="GPCR_Rhodpsn_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05462">
        <property type="entry name" value="Dicty_CAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50262">
        <property type="entry name" value="G_PROTEIN_RECEP_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="7">
        <location>
            <begin position="20"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 1 profile" evidence="8">
        <location>
            <begin position="37"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="297"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="421"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="298"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="448"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI13901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="472" mass="52786" checksum="0CF519D62B7BCDFD" modified="2018-11-07" version="1">MDPSSLQNHNVMHELTLEQRSAISVVERACSVLSLLGCIFTIVTFCSSKAFHKPINRLVFYASFGNMLTNVGTLMSNAYLSELDSFGCQFQSFLIQTFMPADAFWTLAMAINVYLTFYHKFDAERLRRMEIIYLLGCYGIPLIPAFTYIFVRNQQGQRIYGNATLWCWISGEYDVLRIATFYGPVWVTILITFFIYIRAGRTIYEKRKQLYDFQNSDPDPLSINGEVVATIKRTEVTVTEEDAAQQHIHLGPLGKQKAAATTTTTTTTATATATTTTDKSTGCEGAYSVHISADHSDVASSPVQGSKTFQQTSSVQVAPQRPPNPARRRHHELNNAAWSYTKCAILFFTAILITWIPSSANRVYSVVHQNEVFAPLEFMSAFVLPLQGLWNAVIYAVTSWSACQKLFDDLMPRRWRRRCHPSSVESPPDATSLAAAPRKAGHYPSPPRSSRTFDSESMTELAKSRTASADGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHN7</accession>
    <name>A0A367LHN7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_8169</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHN7"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI13938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="57" mass="6306" checksum="1439EC6916858123" modified="2018-11-07" version="1" fragment="single">MRFSTRAVGNARGYGVPAISSGIEAAHPRNSLTTLVARTYIHDNDNYTKSRGLYKYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHP3</accession>
    <name>A0A367LHP3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7908</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHP3"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="68" mass="7850" checksum="B8505BB6442D55DC" modified="2018-11-07" version="1" fragment="single">TIYQKVIQAKVRKADANDSSKYFSRYFKVPTCSTLTYLYTCTCQSDRSDRSDPMTPAMTAMTRPLWPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHY9</accession>
    <name>A0A367LHY9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">O-methyltransferase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_8036</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI14046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHY9"/>
    <dbReference type="STRING" id="1330021.A0A367LHY9"/>
    <dbReference type="OrthoDB" id="1606438at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF19">
        <property type="entry name" value="DUAL O-METHYLTRANSFERASE_FAD-DEPENDENT MONOOXYGENASE ELCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="194"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI14046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="417" mass="45907" checksum="CB8EA958415FC8C1" modified="2018-11-07" version="1">MTQLTSLAKRLCQRAEELEAYTTLHGIEEAASADAAARRELLELALEIQVRARDAADYLEHHQIQYHTFACLGWLLRFNIFTHLPPDKSPVSYASLAAAASVPASRLRSVARMALTSGLFRENDQGLLSHNTLSLSFAEKAAYKHWASFLVNYVQPSAAALAEATARWGDSEACNHSAQNIAFDTDLPFFQVVSSRKDGPDEFARYMTAIQQSTGLCLQQLVTGLDWLGLLGEGAHMVDVGGSTGALCVELAEAYPSFTFVVQDMPDVVSLGPDALSSKPDGIRSRISFQGHDFFTPQPSQAKPPTAYLLRLIIHDWPRQEAIKILSHLARAVKTNGAKIVIMDTVLPPPGSGSTVAQEAMLRVRDMVMIDNFNSKEREEDEWDELFASSEPRLRLVQRTQPAGSYLAMMVVGLDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LI89</accession>
    <name>A0A367LI89_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LI89"/>
    <dbReference type="OrthoDB" id="4927418at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="166" mass="18533" checksum="13C0236788A5909F" modified="2018-11-07" version="1" fragment="single">CIACGYFPARYKESNVIVLRKAGKSLEVLRTPRGYRPISLLNTVGKRGSVSLLMLDITGAFNYLTALIRSYFTSRSSRLKVDGRLSEPFDIERGSELLYFTRARIANTSILTLDGSVIVPTQEARMLSRGRDCRVPIPPLPPYERLETPALRPRPPEGLGQPYSST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIM5</accession>
    <name>A0A367LIM5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_6150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIM5"/>
    <dbReference type="STRING" id="1330021.A0A367LIM5"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13606">
        <property type="entry name" value="Ank_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="22"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="3">
        <location>
            <begin position="215"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="491"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="524"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="558"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI14274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="640" mass="71891" checksum="E8D76E1EAC05A738" modified="2018-11-07" version="1">MRLLRTEDYAIEEFAYDDVPEYAILSHRWAKEELTLQDVQGRIFNKQGFNKIQGCCLRAQADKLRYAWVDTCCIDKTSSAELSEAINSMYLWYYKAKRCYAYLADVLYPKASVERSEWFTRGWTLQELLAPSEVYFLDKNWTDLGTRTSLQQTVSRCTGIPPSILSGERGLETVSIAQRMSWAARRETSRVEDGAYCLMGMFGINMPLIYGEGQRAFFRLQEEIMKMSDDHSLFAWESSDARGGLLASSPAAFSGSSQVMQFNPFDTPKSPLTVSSRGVYVDLRFIGCGKQGLGMAILHCKDRGGEDKKPLAIYLRDTSMTMERFIRVRCDKVARLDTTKFRPSQYPIRRLYIHTQRITLTRNADDTGQQDVSDQLYSVDKIRELMDFTNPTALLRAAELGQLDAVWMLLTRRDVDINLRRSDGHTALSLAVENHKGAIVKALLARNDVKTRLESEGGWDLLTLAVASGDVNIVKQLLHSDKVHVNSKGKQGKTALHYAVLSGSVALVKLLLENGLDVEETDASGRRPLHHAVEKGQEAIVRLLVDEGGADIEAEDRTLLTPLLCAIRNGNATIVEFLLRKGAGVEGKGDWYKAPLAYALDGDSDAIVELLVDKGAKRDWRRSGLCPVLRRKWLSRKSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIT3</accession>
    <name>A0A367LIT3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIT3"/>
    <dbReference type="OrthoDB" id="5208775at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="318" mass="34930" checksum="1ED83B89A353C0F1" modified="2018-11-07" version="1">MVRRLLSKYSRRDIDRLLEEENYACGFCAEIGITKTCTRRNDLRRHIDQFHNTNAIWLCQHPGCRMAFDWQTAYQLHLRNEHGGSQMRMEEAKVTLCPQTVFACGYRGCHHLVEASSDAGASAAWRAYTAHLIKHCDEGRGAAGWDYSHRMRNLLGQPRVAGAWKAVLSSAAAASAAASAADADADADADAAAAGDGERPGLLRWDPGPSRTLRKLLETRHLDPLPRLHEMRQADLGAVRSVMPFRTVPVSDGFVHALVSFRHRPLESETSDDCRWDDVYGPAVTGSYYDVATAAGPVMTPGHHHAALLGAYGPPSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJ03</accession>
    <name>A0A367LJ03_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5981</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJ03"/>
    <dbReference type="OrthoDB" id="5425374at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="85" mass="9833" checksum="45CC9008B209F6D2" modified="2018-11-07" version="1" fragment="single">TTTSNLYARYLFSSTRVVTLILFGLIPKVYNIFVDNIPIRGLETIYDNEEALPRIRRYIFEHLISLNKVLVNIKLASCTIARKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJ13</accession>
    <name>A0A367LJ13_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MPN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_5982</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M67A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJ13"/>
    <dbReference type="STRING" id="1330021.A0A367LJ13"/>
    <dbReference type="OrthoDB" id="10256771at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08062">
        <property type="entry name" value="MPN_RPN7_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000004">
        <property type="entry name" value="26S proteasome regulatory subunit rpn-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033858">
        <property type="entry name" value="MPN_RPN7_8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF7">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="5">
        <location>
            <begin position="16"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="298"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="301"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="332"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI14409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="343" mass="38089" checksum="519EDB638BB1CB84" modified="2018-11-07" version="1">MPTTTADTLSLVTRNVSVAPLVLLSAVDHYNRTVQNKAKRRVVGVLLGQNDGKNVRVSNSFAVPFEEDEKDPSVWFLDHNYVESMNDMFKKVNAREKLIGWYHTGPKLRASDLKINDLFKRYTPNPLLVIIDVQPKESGVPTDAYFAVEEIKDDGTTTSKTFVHTPSIIDAEEAEEIGVEHLLRDIRDVAVGTLSTRVTSQLQSLQGLHLRLHDIGTYLEKVLGAQLPVNHAILGNLQDVFNLLPNLSSPEGDGKAGSGQLAHAMSMKTNDQLMAIYLSSLIRAITAFHDLIENKIQNRQQQEEKDARRDDANKDEKENGPSAVNGDPKGGAQKEKENSQKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJ94</accession>
    <name>A0A367LJ94_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Armadillo-like helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_6091</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJ94"/>
    <dbReference type="STRING" id="1330021.A0A367LJ94"/>
    <dbReference type="OrthoDB" id="2012278at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039868">
        <property type="entry name" value="ARMD3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013636">
        <property type="entry name" value="ARMH3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13608">
        <property type="entry name" value="ARMADILLO-LIKE HELICAL DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13608:SF3">
        <property type="entry name" value="ARMADILLO-LIKE HELICAL DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08427">
        <property type="entry name" value="ARMH3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01158">
        <property type="entry name" value="DUF1741"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Armadillo-like helical" evidence="5">
        <location>
            <begin position="442"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI14494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="673" mass="75961" checksum="9258D8AB6DEA9980" modified="2018-11-07" version="1">MVFGNDMEASPLTRQPPPEVLTPKIVQLYSSLFKDDEDGDRSDGFWKEFFLLRPDLSTLQGLLSEMSPADVLLLESRTRALFGRAVETVKIGQGLAPLHALDTLTIFLSCLLSKKYPHPSSDIIAVLAGLDHIDAVFTDFMSTLDAIVRNGPSCERHLWTLRCIPAYYCVRDSEPAAQGRRRSSGSDCGRLPGDSAHILDTTRSLSVGYEGTFYVFHFFDVLCSSTQFMQESETYDQVLSPFTLLGLLANYNKFEFQNPYQLRLNDFVNESAIQKIIRCAGCTCQALQSDYIAIQEDIPEGWSFSSTLTMIGLGSIVPGLKAEKKPVYDAEVAKRMFSDLPREKAAILLATYDFCHANKLFCFTLVTLQGEGAKERPMASYVGLTSYLLQHAHLSPRATNYAHLNLMVFRLLTEDPVMCKKMCGDESKTSVRLCRQRQPFLPLVKGERVIATCLLDTMIDGINHNLRRRLDIGLYTLCVGIMLRIISYLSRSRTRLDYHWSELFRSLLSLIRFLATYTLDVKELPHVDILLDLVVNLLALSLSAGEAFLPTPAAYDDLFYKVVESGEMLTKFKVNYGLQNRKSNSIDTLISVCTHYEQMLTADGNSSKKKLSNLTTHQVTEVIKQGYETLSIQAKEGLDTWDRFREADERILLKKMARTSVEDARSMMERHIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJQ8</accession>
    <name>A0A367LJQ8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_6430</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJQ8"/>
    <dbReference type="STRING" id="1330021.A0A367LJQ8"/>
    <dbReference type="OrthoDB" id="259769at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.940.10:FF:000009">
        <property type="entry name" value="DNA-directed RNA polymerases I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00192">
        <property type="entry name" value="RNApol_arch_Rpo6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020708">
        <property type="entry name" value="DNA-dir_RNA_polK_14-18kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028363">
        <property type="entry name" value="RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006111">
        <property type="entry name" value="Rpo6/Rpb6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002208">
        <property type="entry name" value="PRK01099.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500154">
        <property type="entry name" value="RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000778">
        <property type="entry name" value="RpoK/RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="RPB6/omega subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01111">
        <property type="entry name" value="RNA_POL_K_14KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="63"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI14673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="152" mass="17044" checksum="80C8F021467D8177" modified="2018-11-07" version="1">MSDFGDDDVGAGGDEPMLEEEVTEFYEPEVGDEDDAERNADGEDQDNVVISGDPSASANALKGGEKSVKDKKIPENERTTTPYMTKYERARILGTRALQISMNAPVLVDLEGETDPLQIAIRELREKKIPLIVRRYLPDGYYEDWTCEELLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LK16</accession>
    <name>A0A367LK16_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LK16"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="79" mass="8779" checksum="BE30F0FABBB3C7D6" modified="2018-11-07" version="1" fragment="single">MEAVVKPAVGPWYKELRLVGSPGYKPWRAPLGPGRMASGAAREHRLASDPDCHQTQTSRRTDGRTRTDVSRPQTHQGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LK22</accession>
    <name>A0A367LK22_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Palmitoyltransferase</fullName>
            <ecNumber evidence="13">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L249_6689</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Palmitoyltransferase specific for casein kinase 1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Early endosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="13"/>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LK22"/>
    <dbReference type="STRING" id="1330021.A0A367LK22"/>
    <dbReference type="OrthoDB" id="6781668at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0564">Palmitate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="13" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="490"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="538"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="79"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="113"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="146"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="179"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="212"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="15">
        <location>
            <begin position="441"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCI14750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="722" mass="79899" checksum="2C409482CC6D726C" modified="2018-11-07" version="1">MDSPKRSGSDVPVAVSPAQPASKSTTAAPQLNSDMELGRLTPAETPTSDIMQLARLGDIAAMERLFESGEFDATFADDEGITPLHWAAINNQYSMCSFLIQHGAEINRKGGESVATPLQWAAQRCHYYTVNLLLQHGADPLITDAQGYNTLHISTFNGNVLLIVLLLHQGIPVDVLDSYGHTALMWAAYKGFPQCVDVFLRWGASVHASDEQGFTALHWALVKGNPGCVLKLIEYGADRFAKTDTGKTPAVTANELNTQPVWHRALRECGYDHDGHVAMPPWPGASYFLKDKRAFVNRFLFLWPFGLIWAALLVLSRLPIFLAIPAAAAVLYGVLWSAREVMEYAPPDMRHFHKTPWMSGIFAGSLFLVGLDWLFVVLPATMRATRGPTHLLLNLVFATLYCLTTFFFVASGRYDPGFVPKLNGIAEQRAVIDELLKEWKYDESNFCVTCMIRTPLRSKHCRRCQRCVAKHDHHCPWVNNCVGVNNHRQFFLYLLCLAVGILSYDWLLCYYFGSLAKDASESCRVLSASLCKMLNADAYTLLLATWTSLQLVWVFMLIFTQFFQVSRGTTTYENMTGIHLGPPTTTTALTSTGAPLDPNLASLADGTRSGPNAQRARGAGGLVKQWSRLLGVDPFIETIAGRGAAGGTNRRRRKNPYSRGCISNCRDFWCDPAPCFARRDNGAAMLGGAKVDYTAMYESPPLMRLTGMRTRGDYEAVGTEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LK30</accession>
    <name>A0A367LK30_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LK30"/>
    <dbReference type="STRING" id="1330021.A0A367LK30"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016908902" evidence="1">
        <location>
            <begin position="26"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="312" mass="34049" checksum="5AE0B6F0547659EF" modified="2018-11-07" version="1">MYLAAATAAAATALVLAAYTRAASSQLSLAGDDGRKCISQSSANPISSQWPTRVTGNLNGTTIIVPIPFPLARKVIPSEYEILQRAYQSLLPGLLTDKYPMMVSALFDHDVMLKSADLSLVDFSRAALEFPFVDRLRDGYSSFRWTGTMLITEGSEAINGSEGYGIRVHPARFDPVCDAYKDQGTFTATASKTGSFLSLSSQPDYDHVPYPLDFIRNITNQPAFATSDHECDNYIRLFNTSLTETPHGPVPVRADVKARLGPLTSGEGEEEEEEEQRWDDVYGWRLSTAFIEPPLPVSCQSLQGYSGTGPGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LK82</accession>
    <name>A0A367LK82_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LK82"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="36" mass="3941" checksum="83B335183B9954A3" modified="2018-11-07" version="1">MYGKDDENDENDCAFYPDEEAAGGDGFDNSNADYAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKD6</accession>
    <name>A0A367LKD6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_6725</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKD6"/>
    <dbReference type="STRING" id="1330021.A0A367LKD6"/>
    <dbReference type="OrthoDB" id="2585655at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF29">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06680)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="517"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI14860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="557" mass="60427" checksum="16DF8E0B27369725" modified="2018-11-07" version="1">MGLGILEPTSGETAPGTTQYFGQPDAPSSDEPLKCDGSVILIPQPTDDPNDPLNWPLWKRDVITVILCVAGVLSTSLSSILAANTVVLTIHFRTSLAQTAVLTGYFLLGTGAAAIFFVPSSRVWGKRHLFLLACCIVVASGAWAGAVGRNYQSLAAARAIQGAAAAPFETLLNAATLLNAAVGDLYFVHQRGVRMAATNLAVFGAAFFTPIVTGKITESLGWEWTFRLVAIFTAVILPAVFLFCPETAFRRSPSPTAADNGGVQQVSWTAKSAAEDSPSPSPAFVAFPTSSAMQPIGDARTPKRSFIQSLSLFDGRKTDERYWVLLLRPFPLLMNPAFVWACLIQGTMIGWTVFIGVLVAILFIGPPYFWGEVAAGYTYIGPFLGALIGFGIAGLLADSSVKVLTRLNRGIYEPEFRIFLVMPMLILGGIGLYGFGMTADAISSGKYHYVIPPMFFGFETAGMVIGTVASSLYIVDGYRDITVEAFTLTIIFKNIFSFILTWYAYDWVIHTGMRRLLTIIATIQVGICLLSIPMYIWGKRLRVFFHRHDPLAMTGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKV1</accession>
    <name>A0A367LKV1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7069</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKV1"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="217" mass="23044" checksum="F77AC74A3B75E00C" modified="2018-11-07" version="1" fragment="single">MAPSAAPPDRAPGDTVGVPIGSLIRKFQGRMGYYRHDGRDLPSCYYHPYNPEIYRIGRIEGSATPCDQVETVLGRRTRCPCYRTTLGTTSQSEAFVPPLDLYLSYCSARTFQLLEANSIAAGIRAAYARGRGRVPSSRTLLPPPPAAATPSSTNTLSSSTTTSSLCLLAGTFITSLSLSLLRSRGADPIRSAPSPPSIFSGVRAASGIYTIGAPLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKV9</accession>
    <name>A0A367LKV9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Clock-controlled pheromone ccg-4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6996</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKV9"/>
    <dbReference type="STRING" id="1330021.A0A367LKV9"/>
    <dbReference type="OrthoDB" id="4920894at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="314" mass="34313" checksum="8966E25259B8BA7B" modified="2018-11-07" version="1">MKRIPFVRQQPATTKLLSSKPNGVRMDRTDQRYKDEVESRPSTPSIKQLKQKKKPSIHLSIPLSLLLRPSIHPSSITKNQTKHLLISKMKFTSSITLFFVAAALAAPSPQYWCRRPNVTCKRATSEASAQESTSIAAPAPLPGAVADYCKRPGSTCKRATPDVLADILKQSEHLTKRDSTTDNAAVVAAHGAIQDLAHMVALTTEDPDQYIQSLNLPSAQHNLERRGRASGACGRRVMCWKRDLEQATVDDKENCHLDDGACSLVKRAAGMVLQSADAAQAAQASTCRSGGTCFRMKRDYLAIRSVADSIADSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKW1</accession>
    <name>A0A367LKW1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase M43 pregnancy-associated plasma-A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_6819</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Secreted metalloproteinase that allows assimilation of proteinaceous substrates.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M43B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKW1"/>
    <dbReference type="OrthoDB" id="536211at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04275">
        <property type="entry name" value="ZnMc_pappalysin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008754">
        <property type="entry name" value="Peptidase_M43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47466">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47466:SF1">
        <property type="entry name" value="METALLOPROTEASE MEP1 (AFU_ORTHOLOGUE AFUA_1G07730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05572">
        <property type="entry name" value="Peptidase_M43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M43 pregnancy-associated plasma-A" evidence="10">
        <location>
            <begin position="218"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI15076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="398" mass="44343" checksum="75B6AE30669875C3" modified="2018-11-07" version="1">MPPSIDNSNPKTVATVLWPGFANGQHASPLRCPVGRPSISPDAVIRRPAAGGGAGQHVKREWWTPHADDAFNSGLILVDTFIHVIVSDVDSFFDVTREMLCDQMDSLNRDFLPAKIVFGLISFEWIIEPEFTNLRDAAAIRSMQNKYNFGDGATLNIYVVSEINLAFNATDCGPPAQHDNGKNASTSGIIEGGLLGVSSMPWSLVEKGEADDGWENAVIIKTESLPRQPLENSFGKTVTHEVGHWFGLFHTFDDDCESVFGDFVVDTPDSAGPTQGCPVGRDSYPDKPGLDPIHNYMDYSSDHCITEFTPGQIRRMHRMWDKFRNPLKRLDGLLPDSGRSLRVRCMQRCLVFEECEVVAVKRHRRPETCWCEFHTDLGDFAENFPCDFRKKRGAGGHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LL13</accession>
    <name>A0A367LL13_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_6404</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LL13"/>
    <dbReference type="OrthoDB" id="5388417at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI15125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="307" mass="33783" checksum="340559A4A1072EF9" modified="2018-11-07" version="1">MQLPHFPPCRSYGQSSIIQGYSHQVFPSGSKKKTPFFRYHVKSSTTTTTTTLLLPPSVARSPLLPTPYMPPTHDAAARRLIPSALSSSTPPSMAMSSSNSLPRWPPVPSSSSSPMAMLNELRRRDGGKPSDGSDNLINMMLIVLGLVFVALSLATLLVLVRRRRRMLIRRRRQQSTLPKYERSSSSSSIPTGPSGLTIETAHRGRASFLYIGRDGQPMLQNPNSPPHSPDNVPEIHITFPDEQDDNGRPQSGRVVVVRVGDNATVGLEPMQGEQLPAYEKESNKFQSLDMDSIGGLKEKRTDDVSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LL88</accession>
    <name>A0A367LL88_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3 7">2.7.7.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_6869</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a central role as a glucosyl donor in cellular metabolic pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>alpha-D-glucose 1-phosphate + UTP + H(+) = UDP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3 7"/>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LL88"/>
    <dbReference type="STRING" id="1330021.A0A367LL88"/>
    <dbReference type="OrthoDB" id="932129at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-alpha-D-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00897">
        <property type="entry name" value="UGPase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000001">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000002">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016267">
        <property type="entry name" value="UDPGP_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43511">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000806">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="213"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI15022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="499" mass="55352" checksum="4556DE7C69E03E55" modified="2018-11-07" version="1">MAYANGLTVPGQAFENTSTNVAAAQMRNALTNLAETVEDPQQKKLFETEMDNFFALFRRYLDDKAKGNAVDWDRIAPPAQGQVVDYEDLANSESVKFLSKLAVLKLNGGLGTSMGCVGPKSVIEVRDGMSFLDLSVRQIEYLNRTYNVNVPFILMNSFNTNDDTAAIIKKYEGHNVDILTFNQSRYPRILKDSLLPVPKDFKSSIAEWYPPGHGDVFESLYNSGILEKLLARGIEIVFLSNVDNLGAVVDLRILQHMIETKAEYIMELTNKTKADVKGGTIIDYEGSVRLLEIAQVPKEHVNEFKSIKKFKYFNTNNIWLNLQAIKRVVENNELGMEIIPNGKTIPGDKKGESDVSIIQLETAVGAAIRHFTNAHGVNVPRRRFLPVKTCSDLMLVKSDLYTLKHGQLQMSAARFGDAPLIKLGSDFKKVSDFQKRIPSIPKVLELDHLTITGAVNLGRGVTLKGTVIIVATEGSTIDIPPGSILENVVVQGSLRLLEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLZ8</accession>
    <name>A0A367LLZ8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_3566</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLZ8"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI15454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="156" mass="17819" checksum="6EEBE45837D44053" modified="2018-11-07" version="1">MYLLAMSFLAPNGFSRGAGSERFVAGAAVTAGKRTRRREGLIFNQKRLEREFDEILIFMTVKTGERQLGGRELGCQGQENRTERAEKVKAAVIFISKSPVRRGPEDEYPIFLFLHLPEVAALETRESETIGYWRYKKVLDREMLSNDVGGWQTDAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LM08</accession>
    <name>A0A367LM08_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LM08"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="96" mass="10415" checksum="60F89413E7BBB025" modified="2018-11-07" version="1">MLLAFGEAQNGRTGGSWVGVTRKALDGIPRRTSVVGQHGVATPGWTMRSPNRLGIAICCELTSQLSLLLTFSFAVSGFYFLFFKIRCCSNIKWVGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LM78</accession>
    <name>A0A367LM78_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_3513</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LM78"/>
    <dbReference type="STRING" id="1330021.A0A367LM78"/>
    <dbReference type="OrthoDB" id="277802at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12246">
        <property type="entry name" value="RRM1_U1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000039">
        <property type="entry name" value="U1 small nuclear ribonucleoprotein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="27"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="141"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="176"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI15528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="193" mass="20830" checksum="65DF786943264628" modified="2018-11-07" version="1">MASKAPGHGLAPNSSLPAKIQSTPPNQTLYVTNLPSSKVQKADLRTALYMLFSTYGPVLDIVALKTMTMRGQAHIVYRDIQTSTQAMRQLDGKTFLGNPMRIQYAKSKSHFVAKLDGTFKIPSTSTGAANVQQTDLQKSIFDAPLPGSAPVSKPADQSMPDADAAGNRGQKRARDEADDSEEDVAMEEDSDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LM88</accession>
    <name>A0A367LM88_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_3533</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LM88"/>
    <dbReference type="STRING" id="1330021.A0A367LM88"/>
    <dbReference type="OrthoDB" id="4150019at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="107"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="149"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="313"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="360"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="415"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="164"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI15521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="441" mass="47670" checksum="A52D8301EAA90625" modified="2018-11-07" version="1">MAAVKTPTVLIKPEPWDFGCSDTSLFLSNPPHALDMSYQYMASPPTASNQAGIGITPPGGGYRSSFKLPSQDLSAIDADCKESDGSYEEHKAGDVLRRSFSTPSATQMQETPCHCRRRKIRCIASTEFQNRCVNCIRLKKECSFYPVDQQPGAESRSRGPPRQTAGSSVASTNSSPAVGTASPGEMTSHHHGHTSVSSKVQPCGDDFYSQDVKGHFMQCGNGNLELTFTAASQYAFANRPSSTKWMADASSASIPKPESINNMPWHSYAAESPISAQFSPYAQSSAASTTWVPELSSHDELAWLDFTPPARSMSLSGESTGSQPTAQYLSVGQGQPFDGRQSALSDMYPQHHFGQMAGMDGSGPIVAATLPSNAEQQPPWQQQQQPPQLLSQSQTPYAKEAASLFDNWQYDKADGPQQLWLDDQRPPSTAGQAPSEAYYSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LML7</accession>
    <name>A0A367LML7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor IIF subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">TFIIF medium subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">TFIIF-beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_3367</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIF beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LML7"/>
    <dbReference type="STRING" id="1330021.A0A367LML7"/>
    <dbReference type="OrthoDB" id="26094at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07980">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000035">
        <property type="entry name" value="General transcription factor IIF subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003196">
        <property type="entry name" value="TFIIF_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040450">
        <property type="entry name" value="TFIIF_beta_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040504">
        <property type="entry name" value="TFIIF_beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10445:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02270">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17683">
        <property type="entry name" value="TFIIF_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIF beta subunit N-terminal" evidence="12">
        <location>
            <begin position="47"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIF beta subunit HTH" evidence="11">
        <location>
            <begin position="280"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="344"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="344"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="355"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00081473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI15631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="377" mass="43430" checksum="9EBB9BC29724399F" modified="2018-11-07" version="1">MADAASFIKPELEEEKPTTPLDDDDLDEDAGDLEYYDKMVNNHQFETLYLARVPRYMWDAWLKIAERLGDDDEIQIGTLRTWIQPEVDADGATHDVTKLRMLLDANCPEHQPLPREYELDILDREVQNHFIFSEDHLPSYKARNKARTEAAKAGIPASLLRQRAQANSQDNHGPQRHSYDRRSRFQPYFRKAIPKKTKLFGKIHYDIRVEPRNVRDEERVLAQKLLDAELSKSKLQIISRNSASSIMNPGTANAAQWGGNFIKNAAQQVKPKKGEMFKAARIPKNQLLDLIFDCFRNYQYWSMKALRQKLQQPDTYLRQVLEEVAVLHKSGRFANHYGLNEAYRDKAGDDAKEEAADDGGEGDEEDEDEELEDVLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMP7</accession>
    <name>A0A367LMP7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zinc finger C2H2 LYAR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_3591</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the UPF0743 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMP7"/>
    <dbReference type="STRING" id="1330021.A0A367LMP7"/>
    <dbReference type="OrthoDB" id="21474at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.490:FF:000001">
        <property type="entry name" value="cell growth-regulating nucleolar protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039999">
        <property type="entry name" value="LYAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014898">
        <property type="entry name" value="Znf_C2H2_LYAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13100:SF10">
        <property type="entry name" value="CELL GROWTH-REGULATING NUCLEOLAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13100">
        <property type="entry name" value="CELL GROWTH-REGULATING NUCLEOLAR PROTEIN LYAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08790">
        <property type="entry name" value="zf-LYAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51804">
        <property type="entry name" value="ZF_C2HC_LYAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger C2H2 LYAR-type" evidence="10">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="191"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="252"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="306"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00061084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI15522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="417" mass="46357" checksum="64FF597A4C7A6FDD" modified="2018-11-07" version="1">MVSFSCEACGDVLAKKKLDLHSNRCHGASFTCLDCMVHFSGVEYRSHTSCITEDQKYQGALYKEKKQKANKMPKDDHKTLSLQPYVEDVGEDGDYAAWTDFAGHTEDDRSPADPPPEAPTPPSAAACDVFDFLVATGQTPNASTAHLPRQDLPLDADDARFMRYKYTAEDFLDPSSLMDAEQSLDVEYGSGPVHNGSLVTPASKAHRRRAKASEASKDKKRKRLHVDVPADQVMTDAPPVVHSNLTDNLKGLMRQTLPPSPDYSGADVADNSPASPLKKSKHTKHAKNGHSIFGVLAGSGKLDKTQKKKKTSKAKSEHRRKEQKESKLIEFRPQSKDGKKRGAHDGQMIVFKPRANAFLDFVTKGPESARGCSMNKALKRYHRERGADLPKSAEEKELWKDLRLRRNDRDEIVIFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LN06</accession>
    <name>A0A367LN06_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Gfo/Idh/MocA-like oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_2560</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LN06"/>
    <dbReference type="STRING" id="1330021.A0A367LN06"/>
    <dbReference type="OrthoDB" id="446809at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000017">
        <property type="entry name" value="Oxidoreductase family NAD-binding Rossmann fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840:SF3">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G10240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42840">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="7"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="4">
        <location>
            <begin position="135"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI15798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="39053" checksum="6B7448112A7D33F7" modified="2018-11-07" version="1">MATRKLQVGVAGLGRMGKRHALNYLQAVPRAQLVAVSTPDPDERAWARANLPGVAVYEHYEQLVHHPRLEAVCVASATAVHAQQAIAAIEAGKHVLCEKPLATTAETSQTVVDAAARHRQLKVMCGFSRRFDESYRDAHAKAQAGLIGRPSVFRSQTCDMLDPSGFFVAYAQFSGGIFVDCSIHDIDLALWFFGEEGDDKVRSVSAVGITAVEPGLREWKDRDNAVGLVEFAHGRIAHLYCSRMMAAGQEDTTEIIGTKGKLTVNTQPTANLVRVHEPGGIRHEVPQTYWDRFKDAFTTEAIEFVDCCLDDKPVPIKLDTAVAAVRIAAALQESMITGNKIWFDDKGERTEKKAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNA1</accession>
    <name>A0A367LNA1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endoglucanase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_2228</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNA1"/>
    <dbReference type="STRING" id="1330021.A0A367LNA1"/>
    <dbReference type="OrthoDB" id="2342176at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017049635" description="Endoglucanase" evidence="2">
        <location>
            <begin position="19"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI15722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="25172" checksum="916E792CA88078E7" modified="2018-11-07" version="1">MKAVLAAALVGFVSLSRAHMEMMFPPPLRSGYNPYTEDQDWDMISPLQSNGQDYPCRGSLHLVGTPQGRVVAEWTAGQQYNVTITGNTPHSGGSCQVSLSTDRGKSWKVLRSYIGNCPVMGSSSYDFMLPSDAPTGEVLVGWSWFNNVGNREMYMNCAVVNIKSGRSSSKRRRSCAAGGAGGAESYATRPDMFVANVGNGCGTTEGFDVEFPQMGPDPVLKSRRTHPPVGKCAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LP28</accession>
    <name>A0A367LP28_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LP28"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="168" mass="18962" checksum="F89C0F0B3106C495" modified="2018-11-07" version="1" fragment="single">MTCSFGGPPRGVMRWMDGCRLTESIRRNRKRIADERQCITFRRARLCATMPPFLFSLSVELTRGFFERGKGMRNRWHETVSRTGLEACGRNEMCNASSKRLLVIKVLPHVVAHCTDYRSVCTDPEEECALEGEGGVEKGGGESEPGHRKSNQAKTMDTRLLARVINVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LP39</accession>
    <name>A0A367LP39_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Pre-mRNA-splicing factor SYF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_2200</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">May be part of a spliceosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SYF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LP39"/>
    <dbReference type="STRING" id="1330021.A0A367LP39"/>
    <dbReference type="OrthoDB" id="199717at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013260">
        <property type="entry name" value="mRNA_splic_SYF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264">
        <property type="entry name" value="GCIP-INTERACTING PROTEIN P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08231">
        <property type="entry name" value="SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI16180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="264" mass="30279" checksum="97AC2F51302C86DE" modified="2018-11-07" version="1">MASPASQQASTTECEEAAGKTRERMARFKALQARAKASSATNFKEATKEAQRLATDPSQLTSLHRNHAIASHKLLKAEVEDAGEDFERKRAWDWTIEESEKWDKRMRKKATHRDNNAFHDDQQESNKVYKRQRRNIKPDLQTYDKQKMAAIERAAASGGLDIVETEDGELIAVDKDGSFYSTADSTSFTQNKPDRAAVDRLVQDMRQAEAQRLKKRKERMANNGDDGDVTYINEKNKQFNQKLSRFYDKYTADIRDSFERGTMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LP78</accession>
    <name>A0A367LP78_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">R3H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L249_3103</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Regulates global gene expression after oxidative stress. Interacts and stabilizes mRNAs and may regulate their transition between different cytoplasmic components after oxidative stress.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with csx1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LP78"/>
    <dbReference type="STRING" id="1330021.A0A367LP78"/>
    <dbReference type="OrthoDB" id="434258at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12253">
        <property type="entry name" value="RRM_PIN4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.50:FF:000002">
        <property type="entry name" value="Immunoglobulin mu DNA-binding protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000183">
        <property type="entry name" value="R3H domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034186">
        <property type="entry name" value="PIN4-like_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF17">
        <property type="entry name" value="RNA-BINDING PROTEIN PIN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00393">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="15">
        <location>
            <begin position="179"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="R3H" evidence="16">
        <location>
            <begin position="325"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="146"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="262"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="507"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="563"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00055199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00062407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCI16187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="613" mass="66381" checksum="134E5E90C5EAB16D" modified="2018-11-07" version="1">MSQQPHDMGFMEYVSPANRSPSSSRQNYGSAFASGLSLPRQSQRPLDAPLGSSVLYPPDRMLGGINPRAMDNMAVNPAIHGGYMLDNGQTWNYSTTGVATVNGAVLGPNRQRSVNRRAALPHTWTDHGPMPLQNALQPFPASLNGGHMQNGGLRLDQGPSHTSPDLRSSASDGDQLIPTAIVIKNIPFAVRKETLASIMVEMNLPQPYAFNYHFDNGVFRGLAFANFQSADDTRHVIDSMNGMDVHGRKLRVEYKKMLPEAERERIEREKRERRGQLEEQHRAPMLHQQASLQSLGSMSQSQQQQQQQQQQRGTSGHLGDVDLNDPQTLEFYTELVMFKRDDSREVLVFPPTIIPEHRRSIHILAHHMGLEHQSIGEADSRQLTVLKRQQPSPTANVQNASVVNSLDMHKRGLSRAATFDFAADRESRAANSNYAHALGRQGPTLELPGSPDGSGIPNNLRAAKSFADLRSFTPSPSQASSSYLAPGAGVSAMGQASTARFGDYMGHVQQVGHPGTSGTPGPKGDNGLAVGLGGLSLSPYDAGTMRNAPGAIGSQRPSNAKAAPERQPRVSDWEVSAASYGPRGAGANGHVQRGSDSSENGVRAVPNKTGRYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPB1</accession>
    <name>A0A367LPB1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_2146</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I NDUFA12 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPB1"/>
    <dbReference type="STRING" id="1330021.A0A367LPB1"/>
    <dbReference type="OrthoDB" id="10255576at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052618">
        <property type="entry name" value="ComplexI_NDUFA12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007763">
        <property type="entry name" value="NDUFA12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32470">
        <property type="entry name" value="ADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32470:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05071">
        <property type="entry name" value="NDUFA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI16268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="178" mass="20943" checksum="719FA1DFA8D5B3D5" modified="2018-11-07" version="1">MASPSMGLLARAWYSWKSLRLPWRKRFLAGYDLAGNTYWEFRLTSRGPPARDHPVRGEPWRRIVTYPRSTPYSDVKVSPLWHQWLRHLRRDPPSLAEQRHDILRQQQVKQLAAEADARWEAKPRLINDDTPKQQQQQQQQQQQQRVDGPRPLPNTRAPGETWQPASWSPAGQNKERPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPX0</accession>
    <name>A0A367LPX0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPX0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="139" mass="15439" checksum="902C86F3442D64DD" modified="2018-11-07" version="1" fragment="single">PSPLAMNLYRQPFRDQPWFHHPEAIPPSPSTSEAPPAAACRSVREIDPSTNTLLSTMPTGGVRRRRLTIMNQQGGTSLQTKTNKQGKQMPHRRCRTFLEIGQGQRAVTGWAYRLTVPNVPSFLDAQPLARKARVIPTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQ19</accession>
    <name>A0A367LQ19_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQ19"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="65" mass="7296" checksum="0937068E5A65B49F" modified="2018-11-07" version="1">MEGNDVRSDDFGAEPDNFPDKGGRDEGGEITSAIFFSFPTLATLPQWQQRAARRPQRANKARSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LSQ7</accession>
    <name>A0A367LSQ7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_2931</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LSQ7"/>
    <dbReference type="STRING" id="1330021.A0A367LSQ7"/>
    <dbReference type="OrthoDB" id="4940293at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.100">
        <property type="entry name" value="YAP1 redox domain. Chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF8">
        <property type="entry name" value="AP-1-LIKE TRANSCRIPTION FACTOR YAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="4">
        <location>
            <begin position="141"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="32"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="134"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="32"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="67"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI17451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="333" mass="36903" checksum="EBCDBB6CC248AE2A" modified="2018-11-07" version="1">MEFSGHYNLGAGAQSAAYQSFLPMPHDFEAPDVVFDPFPPRAFDFAPTYHQPQPQQQQQQQQQQQQQHHHHHHHHQHQQPQAFSDLPTPPPSTAGPTTVFGQQLQGAVTNVVHHISGSVVKGYDDVIPAMQKGSDEEELLTPAQSRRKAQNRAAQRAFRERKEKHVKDLEAKLANLEAEQQKTSVENERLKRDLQEMSTQNDMLRATSSSSAATVGAVVACSSSSPEAHCSPLEEFYPSDEFYSTVLDNTARNWSPSRRVVTSDDGERLLAAGAAWDLIISHQLYRRGLVDVGHVSDRLKSSARCDGQGPVFEESAILEAIEQSVASGSDDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZ60</accession>
    <name>A0A367KZ60_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Copper homeostasis protein cutC homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_4528</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000028">
        <property type="protein sequence ID" value="RCI07458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZ60"/>
    <dbReference type="STRING" id="1330021.A0A367KZ60"/>
    <dbReference type="OrthoDB" id="7392499at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.380">
        <property type="entry name" value="Copper homeostasis (CutC) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005627">
        <property type="entry name" value="CutC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036822">
        <property type="entry name" value="CutC-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12598">
        <property type="entry name" value="COPPER HOMEOSTASIS PROTEIN CUTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12598:SF0">
        <property type="entry name" value="COPPER HOMEOSTASIS PROTEIN CUTC HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03932">
        <property type="entry name" value="CutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110395">
        <property type="entry name" value="CutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="84"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI07458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="431" mass="47552" checksum="B1111716F7221286" modified="2018-11-07" version="1">MRVRQAAVLVLKVYIHPTPQQLAELDFIPSAAEEKEYSVKSSSLLIRCKNRVYVEHIQIPYPYTPSYLLPVLLPNSIFSRKLPAASCQPPLPPQPRPTHPHHHPKKPSSPHKASHQAPKTPHSTEPEGKPITPSSMAPSNLPVYKRMPLEVVVYGRQAAFDAQQVGAARIELNAPGSHAVGGLTPSVEDVIYVRRRLSVGLHVKVRPRHAPADGSPDYVYTTDEIEEMINSIEKFKEAGVMNPFRRDRFVLGALRKATDYEIAAAPGSAVRIDEHACHALVHAAKPLRCIFSNAFDHVIEAGHGKEGCELLSRLGFEGIVTSGGITGTCADVANLDTIDNLCHHFTNRLDIIVGDNIWHETFGLAATRLAVYDENTVWLRTDGIQATDDGSDPTVDYDGIYDLVERLANIQPDWKDPAGHWRETYGDHSAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZ95</accession>
    <name>A0A367KZ95_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">asparaginase</fullName>
            <ecNumber evidence="1">3.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_4516</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the asparaginase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.1" evidence="1"/>
    <dbReference type="EMBL" id="LKCN02000028">
        <property type="protein sequence ID" value="RCI07487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZ95"/>
    <dbReference type="STRING" id="1330021.A0A367KZ95"/>
    <dbReference type="OrthoDB" id="542841at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009066">
        <property type="term" value="P:aspartate family amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08963">
        <property type="entry name" value="L-asparaginase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1170:FF:000003">
        <property type="entry name" value="60 kDa lysophospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.40:FF:000001">
        <property type="entry name" value="L-asparaginase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="entry name" value="L-asparaginase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040919">
        <property type="entry name" value="Asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041725">
        <property type="entry name" value="L-asparaginase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707:SF28">
        <property type="entry name" value="60 KDA LYSOPHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17763">
        <property type="entry name" value="Asparaginase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500176">
        <property type="entry name" value="L_ASNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00057">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="L-asparaginase N-terminal" evidence="7">
        <location>
            <begin position="24"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase/glutaminase C-terminal" evidence="8">
        <location>
            <begin position="262"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="454"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="487"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00061199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI07487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="531" mass="55772" checksum="1B058F2FC108F5B3" modified="2018-11-07" version="1">MAPSQVDTNLDDDAASPAGLPESRVLIIGTGGTICMQPGPDGLTPSDGFLEKALAPRLSFNDMSGLQVQLQAFRNGRSVSLPSLRTPPTEHKRHIRYAVVEFDPLVDSSCIDASDWAAMASAVHENYHLFDGFVILHGTDSLAYTASALSFHFANLGKPVILTGSQAPIFALQSDAVDNLRGSLIIAGTFVIPEVCLFFHHKLYRGNRTTKVSAASFEAFASPNCDPLARVNGLGIDVNWSLVLRPTSIAGFKLGPPLDTTHVACLRVFPGIRAEMVDAVLRLPHLRGLILETFGMGNVPGGANGPLTSAVTAAVERGVVVVNVSQCVSGFASPVYAPGTLLGRAGVIFGLDMTAEAALAKLSYLLAASRESPLSVREMARLFGCSLRGELTEPTLPTFTHPAPPLAAAASRLTPLQAASAALGYAIQAAEPKAAATILDTDDGPTLLNMPDYAGNTPVHMAALSGSSQIMLDLLRRGGSVHARNRANNTPLFLAHLSGNDDVAQLLITAGAHLSADETERGPLAKRTTVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZN6</accession>
    <name>A0A367KZN6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000025">
        <property type="protein sequence ID" value="RCI07653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZN6"/>
    <dbReference type="STRING" id="1330021.A0A367KZN6"/>
    <dbReference type="OrthoDB" id="4509994at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI07653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="92" mass="10542" checksum="4C402E3D965CD772" modified="2018-11-07" version="1" fragment="single">KIRTNKATFRDEEDRIGFLFRSLEGKARKTLETYLLTKTKNNSLSYEDFYGYIKDSPNNLPALAKYSLSILLPKTPLLNRQIDPAVQANAEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZR8</accession>
    <name>A0A367KZR8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">60S ribosomal protein L32</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_1634</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000026">
        <property type="protein sequence ID" value="RCI07647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZR8"/>
    <dbReference type="STRING" id="1330021.A0A367KZR8"/>
    <dbReference type="OrthoDB" id="268693at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00513">
        <property type="entry name" value="Ribosomal_L32_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001515">
        <property type="entry name" value="Ribosomal_eL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036351">
        <property type="entry name" value="Ribosomal_eL32_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L32 AND DNA-DIRECTED RNA POLYMERASE II, SUBUNIT N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01655">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01393">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52042">
        <property type="entry name" value="Ribosomal protein L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI07647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="15040" checksum="87D59979E03FA5FE" modified="2018-11-07" version="1">MVAAKKHVPIVKKRTARFNRHQSDRFKCLSSSWRKPKGIDNRVRRRFRGTMAMPSIGYGSNKKTRYMMPSGHKAFVVSNVKDVELLMMHNRTYAAEIAHNVSSRKRIDIIARAKQLDVKVTNAKAKVTTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0N9</accession>
    <name>A0A367L0N9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PhoD-like phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_7789</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000022">
        <property type="protein sequence ID" value="RCI07999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0N9"/>
    <dbReference type="STRING" id="1330021.A0A367L0N9"/>
    <dbReference type="OrthoDB" id="9999821at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043904">
        <property type="entry name" value="PhoD_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689:SF1">
        <property type="entry name" value="PHOD-LIKE PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19050">
        <property type="entry name" value="PhoD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="496"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="747"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="929"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1028"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1101"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="955"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1133"/>
            <end position="1149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI07999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1155" mass="128515" checksum="28016B9D16EDA664" modified="2018-11-07" version="1">MAAPYWGQLPEPSVAGQRTGQPRPADDVAAAPDSFIGGVASSTERDAKHHHHNHHNQHQHQPQPAAIRPQRMLANDRSPLQRLELTLDSLTKEEKRARVEAAEQRARQRAALRASNQEHNQLSSSPPPPPPLAPGNEDKSERVVVRGEEETDPPPPVRQTSRKLTKAQPQPSLPLSSRNKQLPPIPSLPPEKRPLEADLVDKQRILEASGPVFNGKQRPAEAPAPVLNEKKQQPPARWMDDWKKATTGTLSGPLLDLANDAVVDNRNKAWWEAPPKRPPPPPVFDDDADVPTRFKPPLYLQCGPLLRYCGLRRETLLTRHHGDAIQREIWRGSVMIVTKDTESSYEIAPSLRLFVQNVQLLPPPPQQVDGELPPEYVDPIAGHTKLGRRGETLYVRPVEHVDEARDLSCVERGGLFESTRSPPADGSPADGSRILADGERMQKYKDVRGFRLHTERGCTFWRFNIEVELRERQQRIAYRINRGPPAAFWVPARGQTMNMVFYSGNGFGPDVRPDDLSGPDPLWRDVLNTHQTQPFHVMIGGGNQIYNDGIAEESDLVANWLYTRGADDTVFSAEMQHELESLYLGRYSLGFSQGLYGLATSQIPMVNMYDDHDVLGACGSLPHHLLSGPVFAGIGAVAFKYYMLFQHQSLPTETESSEPSWILGLHPGSYMHELSRSVFVSLGGKTALLAVDCRTERTESTVVRETTWEKMTNRLYAELRRGHMDHLLVLSALPVAFARPENSFTSMLMSPVKTLGRRASMDKMADGGYWVTRAHKRERGIIVEDLQDLAIDKSMRITVLSGNVNLAAAGQFSSNPRLSLAKHRDPRYIPNIITSAVADAPATHKVAEMFGRRVKVHRFDKQTDEGMIPLFRHGVDGRRRSNAHFMPRRSWCSIRQWVPGYTPPPTPPSSGHGTSPSTGVFRRLSSKASRFDAVGRQTDSRPPVSGGGLGLFRSLSRRRSTGAHQPTKLRRTMSLGTKDRGYLSTGWRTDDGRRADRDDGYAALARPAPGPGDEFAAGDESLFTATRRAQPTSNPPQRPFHRTPTGLSAKQRLQADRYAVDLEGGLEVTINVEASARDPAGITVPYRLLIPRLQYEYDPAEDDLAPASPEPGGLRKLLSLRRGRPKPVNDDDHKDDDDDDDDGLSEAEGDGYSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0U9</accession>
    <name>A0A367L0U9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">GPI mannosyltransferase 1</fullName>
            <ecNumber evidence="13">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">GPI mannosyltransferase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L249_7842</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly. Required for cell wall integrity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Endoplasmic reticulum membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the PIGM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="13"/>
    <dbReference type="EMBL" id="LKCN02000022">
        <property type="protein sequence ID" value="RCI08044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0U9"/>
    <dbReference type="STRING" id="1330021.A0A367L0U9"/>
    <dbReference type="OrthoDB" id="1741594at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990529">
        <property type="term" value="C:glycosylphosphatidylinositol-mannosyltransferase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051751">
        <property type="term" value="F:alpha-1,4-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007704">
        <property type="entry name" value="PIG-M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886:SF0">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886">
        <property type="entry name" value="PIG-M MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05007">
        <property type="entry name" value="Mannosyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5 13" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="193"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00025399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCI08044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="453" mass="50640" checksum="95FFE95965699A0D" modified="2018-11-07" version="1">MNKHKPTNPLTLLLRPLPLFLTAALLRLSLLLYGTWQDRNSSVKYTDVDYLVFTDAARFVLQPQHRQATSTASSSPSSSSSSSSSSAFQGPYTRETYRYTPLLAWLLLPTTSIFIAGKILFALSDLLAGYLLLRILRTRKETVASASHASAYAALWLWNPMVAAISTRGSSEGLLAVLTLAVLWAVETRRVTMAGLVLGLAVHFKIYPFIYAPAIVWWMDDEHMRRQVKPTRHSPSLISSVVGFCSPDRLWLAFISLATFMGLNLLMYSIYGEPFLVHTYLHHITRIDHRHNFSPYNMLLYQNSALPSNPSLRIESLAFVPQLLLSCLLIPLAMAKTDLAASMMAQTFAFVTFNKVCTSQYFLWYMVFLPLILPGSSFLRKPALGIAALGLWIASQAAWLHQAYQLEFLGRSTFFPGMWLASLAFFLVNCWILAIIIADGTAGKDAGRKSHLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1B2</accession>
    <name>A0A367L1B2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6345</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5204810at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="80" mass="8771" checksum="1517CAC45A475CC8" modified="2018-11-07" version="1">MPSPQVASPIAMSSSQRSNLRILTSHDICNSLRATLSASSDDRPSTPVRRIQEDDYDVPAAPPPSPVSLRADHWHVPARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1W0</accession>
    <name>A0A367L1W0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7907 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_8859</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1W0"/>
    <dbReference type="OrthoDB" id="3515453at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057229">
        <property type="entry name" value="DUF7907"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25484">
        <property type="entry name" value="DUF7907"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016569963" description="DUF7907 domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7907" evidence="2">
        <location>
            <begin position="22"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI08387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="197" mass="21932" checksum="8C77D7474494CF8E" modified="2018-11-07" version="1">MKLIVLALPFLGRFAAAQSVQSKPFHLVIESSDKHINGQGFTACHTGAAIESLCIYNKAERSTFYLNTTEGSESPLKNYEPSGVLVWNLPVQPTTYSESMSFSVEPSTNVALPLFEPSPSSQYVTFDRQGRLAIVSYLDDTHSPPSGSQPRGLRNWYLCHTYYSAYSYHTLNWVLGSGKAKPQNPSCVKVEVRRLYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1X7</accession>
    <name>A0A367L1X7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_8932</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1X7"/>
    <dbReference type="STRING" id="1330021.A0A367L1X7"/>
    <dbReference type="OrthoDB" id="1928087at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46462">
        <property type="entry name" value="UPSET, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46462:SF3">
        <property type="entry name" value="UPSET, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="6">
        <location>
            <begin position="274"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="121"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="479"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="693"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="798"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="864"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="480"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="492"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="552"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="612"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="701"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="805"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="864"/>
            <end position="876"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI08449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="917" mass="100050" checksum="1216121FA1C1F44C" modified="2018-11-07" version="1">MTEKPSPLPTQTAVPSQPLLAAPATPHVKKEVVASAAETVEEEPYTIKCICNFSDDDGNTIYCETCDTWQHIDCFYPDNREEAIREDFSHSCAECKPRPLNRQKAIERTLRLRNVVVKEELVDKKPKRPPKKKAKPSDLQTSVPHAPSEAGKHGSPGEQPPSSKKSKPSHRQSHSVSSQPSKRSPPNPAHPPSPATTPPDLPVDFQIHHYSAGFCSLYSEQDVPDTLSNAFASLAIPTALSRWLREPDTMKHEVGHSHSDVFQTLPPNAGEKRPRLEIKDSTRSLSPGTLLRWRSVKSTTPIDKDVPLIELNGEIGFQKDYCADPDNLWAHLSSPLPLVFFHPVLPLYIDTRKEGSLARYVRRSCKPNAQLDTYLSDGSEYHFWLVSDRYISASEQITLPWDFRLERSVHVRWLHLLGLSDDDSSVQDEPELDASEYTAISNWIDRILSEYGGCACDLENNCAFARFHRHYLFGKSNGRLSKKKSRKSRNRTISPTSTSHATNSRAASESQANDVADNDARNESNPSRSKPPSRDRTPLLGQFDQLGILTEPTDRDKRKVAMVEDSFRRMEQQQPPRKKKRVSDSASNPPSTAKPKSRNGSAAPPGRYADAGTSSRSNPDSPTSARSPSLTNTIGPASARSVCTSRSRQPSTGLRPAYVDASVQTDVVEGEWFSEPCKPRTPMRRIISLPRRLLNSKLRNRAGDEERERRSLSGPTAGSAASELGSPTGESKPPLAVTPSDPLSPVVAQNPDGLAPGLLQAPTLMTTTAAATTTAATSRAMPEQVKSKVPDLRVQMPPVPAFDGSTTVTTPLSSATSTTTVYSPVVTNLPSPFAPPAVNGIAINPSPIKKKLSLSDYTKSRLNKAAGKAANATAAAHRPGLMSPEETKPDVTMTEPPPVNDKAEDGISPTAGANGFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L222</accession>
    <name>A0A367L222_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L222"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="42" mass="4388" checksum="D0DAC833385698B0" modified="2018-11-07" version="1">MPLALLEQGGSGSSSRSDSSRSSSRSNAWPRGEAGGRARRPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L252</accession>
    <name>A0A367L252_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_8782</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the APC3/CDC27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L252"/>
    <dbReference type="STRING" id="1330021.A0A367L252"/>
    <dbReference type="OrthoDB" id="329563at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF13">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="591"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="625"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="659"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="693"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="761"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="327"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="342"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="394"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="422"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI08488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="837" mass="92179" checksum="1E39C51645E01A76" modified="2018-11-07" version="1">MAPNPLAVGGLLRQIIYYHLDSASYDNALFFAERLVAQDPKSADALHLCALSHLRLGDARSAYDVSKPSGYRATHMGCAWVFAQACLVLERYKDGIVALEKSKGLWSQKCGVGKHSAMTRAPSPDIPTMLCLLGKLHRGYGEKKKAASCFEDSLKKNPFMWDAFTALCDMGINVRVPNIFRSNDLLTQSFELGPSAENGSVYPPDPPPKRPPGRGVAADTACDPFLHGAVSHAGMSTPMSVEAGGDDLLSKIQTAKLRLAASANNQAGIETPMGTPMVEPVASRPAYPTQEPPQAPMRRTRNTQAVEHGTEGPPRMNYRLGVTKRAMRTQERAQEQLPDLMSDSSNGPTASLRSGSLTATDRKRTLSGHPVSRSANLEEPATRRSARLNMFKPSAKANAGAATVGASTGRELKKARPQVSRIVRPGSSGSIVGRVVSGNRKPLEDAMDGDHHGDVLRTRDAPPPLPTMPKLAEPDAAKMEEALRWTLDLTKKLGNGYYFLSRFQSQEALQALSSLPAAHQSSPWVLALMGRAHYEQATYAEAEKMFRRMRAQAPSRLQDMEVYSTVLWHLKREADLSFLAHELVDSAWHSPQAWCALGNAWSLAKDAEQALKCFKRATQLDAKFAYAYSLQGHEHMSNEEYEKALTAYRQAIAADKRHYHAYYGIGRVHERLGAYDKAYEHFHAAQVINPNNAVLICCMGTALEKQKQMAQALSAYTRAADLAPRAAQTRYKKARALLTVGQMEAAQRELMVLKDLAPDEATVHFLLGTLYKKMNERQLSVRHFTIALSLDPKVSDFKAILPLMRLLMRGYLQAAPKIKEAIESFEDDVPMDDSMVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L284</accession>
    <name>A0A367L284_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_8922</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L284"/>
    <dbReference type="STRING" id="1330021.A0A367L284"/>
    <dbReference type="OrthoDB" id="3363151at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043007">
        <property type="term" value="P:maintenance of rDNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007096">
        <property type="term" value="P:regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018819">
        <property type="entry name" value="Nur1/Mug154"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28293">
        <property type="entry name" value="NUCLEAR RIM PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28293:SF1">
        <property type="entry name" value="NUCLEAR RIM PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10332">
        <property type="entry name" value="DUF2418"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="294"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="404"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="569"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="711"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="838"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="995"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="423"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="592"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="720"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="769"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="780"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1006"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1020"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1043"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1057"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1076"/>
            <end position="1092"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI08543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1211" mass="133054" checksum="53185FFD5A59B1FA" modified="2018-11-07" version="1">MPRLVRRRPLRERVLAMLNPMDLLLWLSEEMETRDWDSQLVGTQLGLGLNFSLLLARANSASTTPMFNDDLFGDTGGSRWLYLMVWPLVWALGALSLTNAVYAFYRTRKYRLFQASVDTQPATPSARRVKVHSSPASSSPLRFLADMVTPQSAESRAHPNNDTDVWELAVWDPLTLSMRLLCFFSPGHVLVYWLFLPLAPLDPRPSMTVFNSLVMQVVLSVQMLMLCARFTRQAKDNNIIQKEVMREYDAKFVHPRLYPVVRDVGTQVSEDEPAETPGSVQLGTPTTLLRRGFKTHGNPHVDSPDSPLVGGLMRPQMFTPPPASRRAEASPSSVGFRGPAVRSTLPSAPSPHVEAGPLPGGGFNFGGMFGVYTHSKSPLKKTISQSDLASQPLPKTSREMAAYEQLGRGPSRSPAKQSKDSRTASGQAASQPLSNTGSDWDGAVSIDGHSQGAGQGRRAGAPEGHIAFAEHCSPVSACTGVRKKLVATNDLFLVAGRVHPAANERDRKPSIATADVPRTKAAVVPAGGVEAKQPDNKIRRHITSSCRRSSQGHGPDQILRWNMAQDLPKGAQPETARPRVAAGPSSRHQAVTRKESHRVSRPEPVVEKRHVQTMEERREARRQRRTLKESGDYLGVQGINPATGQLDIMTPTDSDGSSEKQQKLNVLRAALRDARQSYRDVKAQSEREARRILDSEARKLRRLEKEKQKLQKLSQRVRWQRQTKQWSSAQEPELSPIVGSRRGSSAQAGRLSRHQHPDVMSRVAVDLGRQPRDHYDTPDSTRTVVRTPQRQSLATPSAWELFANGITFDNSEPAAESFLGSGAELGRVDTGETMMNSSTIIPGPRQRNNETKQGQSLRPAARSTLRRLMTPLENLKAAKRNEAQLSAGVVQPRCQQRGPAAEAERPAVVQPVGLTTGQLHPLSSAQLGPQTMLDDEWMERALKDLADTGDRYTKEPASTRITTTTGFDQVISMSIQAEGGEAARRQQSSILCNLSESRFLDDNDDSSSSTTMKTTQNTSPSSTPAPSGEVTDTTSVVTEQRHSTSLKSTSSQQTMMHGDDHGSGDGRDGSHEANRQTVTHQQQPGQTTTGQQLAAASKKTTEAPTRWQASDERSALDMELCLLTARMPGTFPAETEGGRESEDGKSWRWLKKTIARAATSLPQLYWTTVTPVIDWRSDYWARAERNEMTLLDGVALVLAMPAALMAMVGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2R0</accession>
    <name>A0A367L2R0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosyltransferase family 15 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_4837</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2R0"/>
    <dbReference type="STRING" id="1330021.A0A367L2R0"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF7">
        <property type="entry name" value="MANNOSYLTRANSFERASE KTR4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016578668" description="Glycosyltransferase family 15 protein" evidence="5">
        <location>
            <begin position="20"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI08698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="396" mass="46816" checksum="B068CFE5ED32F2C9" modified="2018-11-07" version="1">MAIARPVRALAFAAALCWCLVIFHLIKVPSPEIHGPGERYLNFERDPNLDPTGEPDGRLRRASSRYAADATDSARIPATLLALVRNEEVDDMVESMKDLERTWNHNFNYPWTFFNDKPFSEEFKSKTQAVTKAKCNYELIPEDHWATPSWIDQRIYDESTKLLEEKGVQYAQKISYHQMCRWNSGMFYKHPALEKYRYYWRVEPKVHFFCDIDYDIFAYMFDNNKTYGFTINLYDDPKTLPTLWTETVKFLSDHTNHPVHEKSALNWLTDDKRRPDHNRRAQGYSTCHFWSNFEVADMEFWRSPVYEDYFNHLDHAGGFFYERWGDAPVHSIALGLWEDASKIHWFRDIGYQHIPFFNCPNSPKCKGCVTGRLTDGEPFLHREDCRPNWFKYVGMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2X6</accession>
    <name>A0A367L2X6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SAC3/GANP/THP3 conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_4803</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367L2X6"/>
    <dbReference type="OrthoDB" id="264795at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007307">
        <property type="entry name" value="Ltv1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF3">
        <property type="entry name" value="GERMINAL-CENTER ASSOCIATED NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04180">
        <property type="entry name" value="LTV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC3/GANP/THP3 conserved" evidence="3">
        <location>
            <begin position="517"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="200"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="258"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="366"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1027"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1127"/>
            <end position="1185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1264"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1512"/>
            <end position="1687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1760"/>
            <end position="1835"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1453"/>
            <end position="1480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="201"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1030"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1049"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1127"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1303"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1323"/>
            <end position="1343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1526"/>
            <end position="1543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1552"/>
            <end position="1570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1581"/>
            <end position="1618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1626"/>
            <end position="1644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1658"/>
            <end position="1669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1670"/>
            <end position="1687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1809"/>
            <end position="1823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI08779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1878" mass="207791" checksum="26C358CB2C16DDB3" modified="2018-11-07" version="1">MPRGKWINKKTAQHFTLVHRPQNDPLIHDDNAPSMVLNPTGSSKAKHLDDLASELGLDAATIRANEGEAASYGVFFDDSEYDYMQHLRDLNTGGGDVVFVESNPAASKGKGKQKLSLEEALRSLDLEHKSTSVLDEEMLPSKNLTRVTYEAQQDVPDCIRGFQPDMDPRLREVLEALDDDAYVDDDDDIFQTLAKDGRELDDFEFDDEDDEGGWESDDTAKPAKEYNEPVPDLVPTSDNLPEQGPSQDWLRDFNKFKKDQNKSGMPATASHSEMQSAWTTTTNGGKRKKRKGALTDASSYSMTSSSLVRTEQMNLLDARFEKLEERYNEDLDDDAGSVSVVSTASSTTGPVRGDFDDILDEFLGNYSKPGKRTSKKSKAQTGLQQLDEIRRELGPPRDPFLRDLDDTSFDGPRSIAETSSSSVVMAGDDVEDVQDVQEGLADRIHQKLRAHGIKPPAWPSAPGATENHQEMSRFRDLYEAYRHKVRAALTKEGLIDDPDKRKRLSDAIEFKGICEEMCPEYETITRISEHDVNRPERDPQTGVVLVQKMVKKLARSAAGQEAPLPMDVRSALTLQRTLDYLVDMVLRQDSNLSSVHPFLWDRTRAIRRDFAFFSSMSEAEVRSQVYVLENITRFHVTSLHLLSRGTKKEDTFVEQQELEQLGKTLLSLRDVYDDCNEQGIACENEAEFRAYFVLFHGRDTGILETLQRQWRPNLWQDSDEIRTAVTLVEALQNTQEIIGSRKDGHAGPLLAASGPNVAYFDIVEDAMVSYTMACFAECHFQHLRRSLLATVKRSLARPKSPIEDVTAADLNEFLRFDMVEQAIEFARLHSLDFVPDQQFPTDIARQFLVLNDRAPLPHVRLEHQFSQSLVEKKRGTASLPDVIHMTIFEGANGRQTISNGVDGHDSSSVQDDHRSPFVEDVHYNPFAQVVPETQVWLHKGHRVRDRPVESAAERTSEAGSSKAKDMTFKNSAFIMESGTRLDSVATDDAARSLVLGLEDGLANLLLDTEEDAQDAAAASQHKRQLYNPFASDSGSTEAGGAKTSSRLPTLEEIRSKEQGHFLRGVPRKTIFTPKDASAPAKTNPFASPLQLPPQLKTGFGASKPNPFAPNPSSVSVPVNNPFAAPVQPSTGSAFPGSAASNAPSQNWHNPFAPTPQVVERQDTDSSRTRPNPFASLNKPDAGVAATTSSSVLPSIGKHSELAVPAASSAASSHMFGLGAGSTSSIQNASPFMTAANHQNEQPSSTMERAGASFAPSMALPGLPQAVPVQQSSSPAIDEPKHQNMAGSIPGERSVPAKAVEAQAQPQSATEAQPRSGEPRLELVPASSAPASSAVEKVSEAPEVNSPAEETTTKKQELLAGFTNWYVNGDNGLMSDFLLNTVTRITENAWEIFQREEEERKAREEREILEARGQQFRKHKTASKVLRHWRQVAKARSLARVARAGRDAMREHILERMKAKRDAAMNARREIEQRQEKTMQEFRQLLKSQREAREALLASGVLSGVRGEREAADRIVADDSVASDVSEPSKSKSEPRKSESEPRKKPNGAPKEVSNDKPNETDKEAPREHRLTNFQRAFASKSVKESPKTDSPKTDKAPREHPKTDFRRSASTKAGKDSPKTNSPKTDSPKTDSPKTDKAPREHRMTNFQRAFASKSVKASREHPTTDFRRSTSSSTTQPRQSSSPISPYWTLKAMGIVPLPDGTAVPEIMAPEMRKRFRTLPSVEQIRNRRIAAVKALDEALEGTAESRAKFLAEYKSPLALSKRKRAGEDDVNDGSKRRAAAGEGASSVVRSSPSATNKRKRSSLSGAVDDDDDDDDDNEDNESSDRGSLPQSVIMGEKMIAELRALRADLEEGAAWFRAESEKMMRENERRRQGGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2Z6</accession>
    <name>A0A367L2Z6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2Z6"/>
    <dbReference type="OrthoDB" id="4931909at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56973">
        <property type="entry name" value="Aerolisin/ETX pore-forming domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="439" mass="49560" checksum="4D48B8F36BE2BDA4" modified="2018-11-07" version="1">MHALVPRQQTFSFHTRYIAEMKLGPLITVLFSATAFCQGVSREVTSEHHIKEVLAELQKNIKLDEENLPRYQKSVKEPACGGLNGLWWFDCWNLEFVENMQLVRHNGSLGTMSMSVERQVLRRARNTQKKEPVSLSVTTNEIDMKSATTGWNIGADINAGSWNPINGFNKGISVSGGYSSSTTTSKSISVSFTSSLTCPPRHTCRTEAWTVYLTVTGYCTSRPQLKICGKTLDACKGPLHKSGQCSQVEAWRDRVCKPEAVQKCTVKTPVTEGKLPYFEEVFFERELTKEPTKTKGDVVDEKGGDVDDKRGDAGDKGQQDGKESSRWVDGWQFENVDGDVKADEEDGGGNEVVKAIGINREGWCGLTDGWLYDPENDTYRNPRGEAKWVKMPGRKKPAEWEKWCDPETKDEWKATWEKLDREEEEKRKKSGLLRRLGFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3M6</accession>
    <name>A0A367L3M6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L249_4932</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the glycosyl hydrolase 18 family. Chitinase class III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI09036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3M6"/>
    <dbReference type="STRING" id="1330021.A0A367L3M6"/>
    <dbReference type="OrthoDB" id="2425929at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02877">
        <property type="entry name" value="GH18_hevamine_XipI_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045321">
        <property type="entry name" value="Cts1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF49">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="5" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="10 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016696514" description="chitinase" evidence="14">
        <location>
            <begin position="21"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="15">
        <location>
            <begin position="36"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCI09036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="340" mass="36065" checksum="44F7D921A9DCF63E" modified="2018-11-07" version="1">MPSLFSSFTCGAGLLALVSSAPTLIQSGGGGGGGAQNLAIYWGQNSYGQGSGPNVQKNLAYYCENPKINIIPLAFMNGITPPIVNFANAGDRCETFNGSGLLRCPEIEADIQTCQKKFNKTIVVSLGGATYTQGGWSSPAEAEKAADLVWAMFGPVPAGGNYSSVQRPFGAAVVDGFDFDFEAVTNNLPAFGARLRALMDASSGYAPQKHFYLTAAPQCVFPDAAVGTTLDAVPFDYVFIQFYNNWCGVSNFQPGAATQPAFNMDVWDSWSKRSKNPAVKVLLGIPANYGAGGGYVRGPKLTSVIQYSRKFSSFGGVMMWDMSQLYANPGFLEEVVAALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3Q5</accession>
    <name>A0A367L3Q5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI09054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3Q5"/>
    <dbReference type="STRING" id="1330021.A0A367L3Q5"/>
    <dbReference type="OrthoDB" id="5561579at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019727">
        <property type="entry name" value="ATP_synth_F0_fsu_mt_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28161">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT F, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28161:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT F, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10791">
        <property type="entry name" value="F1F0-ATPsyn_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="96" mass="10895" checksum="0943761B264BDB54" modified="2018-11-07" version="1">MSFVTRRALSTLIPPKAIGAAPDALRMQRVVSFYEKLPRGPAPQIKGKGLLGWYQAKYFGDKTSVKPIIHIIAFMVGIGYVQNYYFHLRHHKNNAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3W4</accession>
    <name>A0A367L3W4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5028</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI09125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3W4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="285" mass="31752" checksum="880FB97C4A848E2D" modified="2018-11-07" version="1" fragment="single">KEDGKLDREPAKGVIYPVYDCVLFIPLQSKGPEGVPRGFHLLDAVFCFLSQPVASSQTAPPISCDRHRTSIIAFTLQQLRNLLLRDVYTSLSAPVDGVRRPRDKGAHVVRVGSYPRHLVDAAKGAEEIAFSLLAVRHVGLRQAEDGGDAHSSVCHNKTTPAPRETMEKGRSIIAMKPRAFVSTQLRFNVAGPQLSLNFHPVFNTMAGIRLRRRKRRHLRTPCTEEAGARNACITKDMSISSQPSETLNHYPTPLTYLFIEVVTPQRPRISDIHHVRLPIAQHQVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L439</accession>
    <name>A0A367L439_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_1443</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L439"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI09203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="69" mass="7493" checksum="FAE12F5D42075833" modified="2018-11-07" version="1">MQIDIVAFISGYYSARWVGVLFSNISPRVKMVGMQVGGSSMQAVTLNICIYVTPAVIGWSSAFPPYSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4A3</accession>
    <name>A0A367L4A3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nuclear pore complex protein Nup85</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_5141</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
            <location evidence="9">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aconitase/IPM isomerase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the nucleoporin Nup85 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI09042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367L4A3"/>
    <dbReference type="OrthoDB" id="2224430at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003994">
        <property type="term" value="F:aconitate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.19.10:FF:000002">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.499.10:FF:000003">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1060.10:FF:000001">
        <property type="entry name" value="Aconitate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1060.10">
        <property type="entry name" value="Aconitase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.499.10">
        <property type="entry name" value="Aconitase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.19.10">
        <property type="entry name" value="Aconitase, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015931">
        <property type="entry name" value="Acnase/IPM_dHydase_lsu_aba_1/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001030">
        <property type="entry name" value="Acoase/IPM_deHydtase_lsu_aba"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015928">
        <property type="entry name" value="Aconitase/3IPM_dehydase_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050926">
        <property type="entry name" value="Aconitase/IPM_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018136">
        <property type="entry name" value="Aconitase_4Fe-4S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036008">
        <property type="entry name" value="Aconitase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015932">
        <property type="entry name" value="Aconitase_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006248">
        <property type="entry name" value="Aconitase_mito-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000573">
        <property type="entry name" value="AconitaseA/IPMdHydase_ssu_swvl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011502">
        <property type="entry name" value="Nucleoporin_Nup85"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01340">
        <property type="entry name" value="aconitase_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005558">
        <property type="entry name" value="PRK07229.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160">
        <property type="entry name" value="ACONITATE HYDRATASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43160:SF2">
        <property type="entry name" value="HOMOCITRATE DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00330">
        <property type="entry name" value="Aconitase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00694">
        <property type="entry name" value="Aconitase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07575">
        <property type="entry name" value="Nucleopor_Nup85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00415">
        <property type="entry name" value="ACONITASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53732">
        <property type="entry name" value="Aconitase iron-sulfur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00450">
        <property type="entry name" value="ACONITASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01244">
        <property type="entry name" value="ACONITASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Aconitase/3-isopropylmalate dehydratase large subunit alpha/beta/alpha" evidence="11">
        <location>
            <begin position="1107"/>
            <end position="1552"/>
        </location>
    </feature>
    <feature type="domain" description="Aconitase A/isopropylmalate dehydratase small subunit swivel" evidence="12">
        <location>
            <begin position="1636"/>
            <end position="1762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI09042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1833" mass="198493" checksum="2789491AEC961899" modified="2018-11-07" version="1">MAERFIIDSSPPVSPAPSTPDGKNRHSVFPPNPPSMTPMGPPPQSSVASFTPAGAPTGSLLGSSLLRPSGPFSQSRNSSRNRPFGRSTRGKERQPSALSRQMHVDDGDSDHDELNDEPNLPHLPGSLFRGPDDATEDIIDAAMSRYIDQEIDAQVESEPGSSSDDDGDIFLNMRHDDRPYDVPPIGEGDDMIMLNTPSAINRVQKEAEEIFRRSTARFGGGPGHREFQFAAIARAFYLDQEPAPIAESPQLILDTNQLVRRLYDEGVGTEDDAEKMDSSLASITCQLVRLWDDYAVGLSQPEGECVATVGPGPEAEPFQKAAFVAHLMVRMHHTRFDAEGAVDDKTPPLPEVMFDWLRQSHNLYPDQVRDIGRCRPSPACHGLFWQTVRGAVLRGDIKDAAYLLRNAGWDKVRRGPNGDAVYAEEALDNIRRYVDATCAMLEQCPAVVSDWDVDNSSWTLFRVQAKGSLDKLTLFAEGNLDRPEARGPQSISTMARKAASKIPWDVYENLQTLYGIVLGKLEPIMNTAQDWCEATVGVLGWWQDGRKSQSMSQSRALGASSMLGGSLLGASTSSRTAALADDRLDRLAAAFHCVLRFDLRPNPMNAVEVAVGSAFEGNVDAVIGCLRVWSLLMASSVAEIASLGLWLPRPQLSKPAPMDALDMEDLALLGVDPPSVDETEGIKDTTLILYARGLAGIDRLSLTQDGWEVALQVLGRMDSAEKADETVAELLRDLLETLDVDSNAVVEKIWRVLNDLGMTKYAEETANTYAQMLARECRQFGEVLWYYALAHRPDSVREVLNLLIAHSLVDSKAFPAEADLDPGLRDLLEKRTETLERRAKQDLEAAQLLGRMLSGYATLRKFYDYRDSIRDVPSTSSRAISVRKKAASALVAVIASADDNIRGGLYDMERDAVVSEDFLLVLLGEATALVDDGPVAMTPDQIEVMLKAIEDLETVGGRVYGVSDDFLHTVLASCPGLKGSTPADLMMKRSTGSLSDSYVMSGSSMLASRLHETARGGKGERTSRGWDWRRAWMANTKGADVLRKLRRGLARDLASLWLQEADGVATCVRRAAASSASTLRPVYQRLLATYGAARRVIGRDRRLTLAEKLLYSHVVDAEASLSPGCQDKPLRLWPDRVNMQDASAQMALLQLLACGPSARAALPASIHCDHLIVGARGASDDLRAGREANSEVFAFLETAARRFGLDFWPPGAGIIHQTVLENYALPGLMMLGTDSHSPNAGGMCTFTVGVGGADAVEALVGAPWELRRPAMHGVELVGKLGGWASPKDVILHLAGKLSVRGGTGAVLEYFGPGVESLSLTGMATIANMGAEVGATTSVFPYTDATARYLVSTGREWAVDAVQELSSQEGGGLRFAADEGASYDRVTRIDLSELEPHINGPFTPDLSTPLSRFKETVRENGWPEKLSAGLIGSCTNSSYEDMTRVQSLLRQAADAGLRPAADFFVTPGSEQIRATLERDGTLDSLEAAGGVVLANACGPCIGQWQRRDGVGSGTTNAILTSYNRNFRGRNDGNAETMNFLASPEVVTAMAFAGSTTFNPITDSLFTDDGTEFRFSAPSGLEGPPEGFAPGRSSLAVLSSEPDASVAVAVSPTSERLALLQPFPPFPPGQDDLTDLRVLVKVKGKCTTDTISAAGPWLKYKGHLANISANTLNTATNASTGEVNAAYDVDNTRHTIPDLALKWQRRRQSWLVVAEHNYGEGSAREHAALQPRFLGARLVLAKSFARIHETNLKKQGVVPLTFEDEADYDKIDACDVVATEGLYSMLARGGKGDVRLRVTKADGEEVAIPTRHTVSEDQAAFILAGSVLNYMIKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4C7</accession>
    <name>A0A367L4C7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein-lysine N-methyltransferase EFM6</fullName>
            <ecNumber evidence="1">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Elongation factor methyltransferase 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">EFM6</name>
        <name evidence="2" type="ORF">L249_1491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. METTL21 family. EFM6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="1"/>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4C7"/>
    <dbReference type="STRING" id="1330021.A0A367L4C7"/>
    <dbReference type="OrthoDB" id="407325at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03198">
        <property type="entry name" value="Methyltr_EFM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033684">
        <property type="entry name" value="EFM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF152">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EFM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="95"/>
            <end position="97"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="152"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="252" mass="27743" checksum="11D05FF708215635" modified="2018-11-07" version="1">MEFSSSSSNSSSIVADTAATMVVSDELTPLPMLKQPGITTIDLDGQLDDNKPLRLLEDVRAGCGGQTWPAGLVLAKNMLRYHRHELSDARILELGAGGGLVGLAVALGCMSITAAAKGSILLTDQQEMLGLMQRNMQLNDVGDKATALELNWGQDLPEAVVRQRPNVVLAADCVYLESAFPLLLQTLQDVLALNDDAVVYFCFKKRRRADMKFVKMANKAFSVQELFDEDRPLFQRQSLFLFSLRRKPRARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4K6</accession>
    <name>A0A367L4K6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_3762</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000015">
        <property type="protein sequence ID" value="RCI09365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4K6"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI09365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="107" mass="12209" checksum="ED33B5980811AC21" modified="2018-11-07" version="1" fragment="single">MSDGFSLDLVESAIPWRLFQSTFQWPPLPRKTRMLEFRSQTVLHPPAKGDTRITELAERQGEPGIRIDGHESDSQGTAALWLTSVFQGRRPCDPFFTECPFTGTTYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L543</accession>
    <name>A0A367L543_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_3697</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000015">
        <property type="protein sequence ID" value="RCI09342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L543"/>
    <dbReference type="STRING" id="1330021.A0A367L543"/>
    <dbReference type="OrthoDB" id="198619at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03713">
        <property type="entry name" value="EFG_mtEFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000514">
        <property type="entry name" value="Ribosome-releasing factor 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053905">
        <property type="entry name" value="EF-G-like_DII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43261:SF1">
        <property type="entry name" value="RIBOSOME-RELEASING FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43261">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22042">
        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="5">
        <location>
            <begin position="9"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI09342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="783" mass="86134" checksum="5759FB6E031E5138" modified="2018-11-07" version="1">MANADGEVENTRNIGIIAHVDAGKTTTTERMLFYSGVTQRVGNVDAGNTVTDFLELERARGITIQSAAITFNWPLPQDCPPGAQPKTVNLIDTPGHQDFRFEVDRCLPVLDGAVCIIDSVKGVEAHTERVWASAQEFNIPRIVYCNKMDREGASFKRSILEIATRLRGWPLVCQLPWWEKENFVGVIDVIHEVGYRWKSDKIKTRYGPEELRELLSSANKNLLAEIQVARDRLVEGLAEFDDAIMNEFLAENPKIPASLLTQAIKRVISKGDGRLIPVFAGSSSRHIGIEPLMDAITDYLPSPSDRPDVEVQVDSSKHRLGEVLKGAGKKGNVASVASVFKVSNHPKEGVISFVRVYHGTLIRQSPTFNTNLGKSERPYGILQISASQTRDIQELCVGQIGALKGLRSARSGDTLLTMSSGKTAVDPIRRIQIRPPDIPPPVAFAQVNPFGKVAADLLQAALENKSREDPSLRWNRDIATDEFTIQGMGKLHLEISLHSMKQRKDIDAQYGDVEVDYKECVTGPTPSHHIVFDKALNGIPGKAACTVALEPIELLGQGRKESRNSIEKDGNMFQVEIPKPENGGPLPFHREDARMQLINGALAAVARGPRRGFPLQGCRVSIVLDTSEGAYDRPTAGHFSILGKMAVDTALKDALGKQQVAVLEPVMLAHFMCPEDAAGLVQHDITSVAGGQVLEIADRSSEPTDGDFVDTSRIYTPPDPWDAITSLRDKRAVNRVVEIVAKVPYKNMLDYDSRLRSTTAGRHTVTMSFDSFARVVGKRERDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L548</accession>
    <name>A0A367L548_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">SNF2 family DNA-dependent ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_4064</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L548"/>
    <dbReference type="STRING" id="1330021.A0A367L548"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16449">
        <property type="entry name" value="RING-HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF52">
        <property type="entry name" value="SINGLE-STRANDED DNA-DEPENDENT ATPASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="481"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="853"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="964"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="23"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="150"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="364"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="517"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI09528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1140" mass="126863" checksum="04BD6EC51D196BAA" modified="2018-11-07" version="1">MAANDSLPTSYYSSPSASSDAVALPAFASTTPPPPLPPPPTAYPPPPLSASSSHLSAQNHAHGAHPTAASSAWDPTALLQPNRRVNSAMELGRSSSMDPPAAHRRPARYEARSGAASPVQFLFSSPDETSDPSTLGGLSSAASMFERANNVQSRDLVPEPKRRKTQDAANSSEIPVRAGTGVLGAYVKEKRAAPPQTVDLTDANDDDDVIMIADSKDEEVCFGMIKSGLNCSTVPSPRPGTQSLWGPGYQPAIKIVLKRQVNERSHKIHASDHTREIIGLVEPKTAAAFCPLLDANLRLRTDCRIPSQPKKPGEEPGQPTSRSYDLDVVVYGPRRYAKVVGSHLQKQNFVLLSPSIVQKGIKYENPHSSEFRPPPPRVYPTDSRGSSSGSVNRTVEEIRSEVMGVFDSLKRNDDLPCKEPDARVTTSLLQHQRQGLYFMLMRERPLSEQANEQGMVSFWQDKKDDRGQRIYFNVITGLRQREAPPETRGGILADIMGLGKTLSILSLIASTTDDAAQWEGREPVQRPAADAGHKTKDGLGMHQPSFDPLPVTRQARSTLIVCPLSTITNWEEQIKQHIRPGSLSYHVYHGSNRIKDAAKLASFDIVITTYGSVSNELSTRRKRGEGLYPLEEIGWFRIVLDEAHMIREQSTLQFKAMCRLQAERRWAVTGTPVQNRLDDLAALLSFVRLHPFDERSKFYRYIVEPFKACDPQIVPKLRVLVDTITLRRLKNKIGLPERKDAMVELKFSPDEQALYDLFERDAYDRVKVLAGPNTSKALGGNSYIHILKAILRLRLLSAHGKDLLNEEDLVAIRGMSAEMAIDLEDGEDDTLPMSHKKAHSMFVLMRDTNGDTCVECTKRLYTTETQNMDSETQDDVFGYMTSCFHVVCRSCINSYRERVLPLLEPGRSSARCPECDALTRFEFVELRREAVEAEREGSARTKSRAGQRKRLDKYEGPHTKTVALVEDLLRSKAESEANPLEPPYKSVVFSGWTSHLDLIELALQAANISFARLDGGMTRTARTAAMDRFREDRTVDVMLVSLMAGGLGLNLTAANKVYMMEPQYNPAAEAQAIDRVHRLGQKRPVRTVRYIMQGSIEEKMLEIQEKKMKLASLSMDGQDKALDKEEAAKKKLQDLRSLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L579</accession>
    <name>A0A367L579_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Histidine--tRNA ligase, mitochondrial</fullName>
            <ecNumber evidence="3">6.1.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Histidyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L249_4020</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the aminoacylation of histidyl-tRNA in both the cytoplasm and the mitochondrion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(His) + L-histidine + ATP = L-histidyl-tRNA(His) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L579"/>
    <dbReference type="STRING" id="1330021.A0A367L579"/>
    <dbReference type="OrthoDB" id="1906957at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00859">
        <property type="entry name" value="HisRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000015">
        <property type="entry name" value="Histidyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000021">
        <property type="entry name" value="Probable histidine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004516">
        <property type="entry name" value="HisRS/HisZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033656">
        <property type="entry name" value="HisRS_anticodon"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476:SF7">
        <property type="entry name" value="HISTIDINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476">
        <property type="entry name" value="HISTIDYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001549">
        <property type="entry name" value="His-tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="16">
        <location>
            <begin position="58"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="339"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="343"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="127"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="327"/>
            <end position="328"/>
        </location>
        <ligand>
            <name>L-histidine</name>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00058343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00067413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001549-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCI09593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="513" mass="56942" checksum="66FE8AA49053EDD2" modified="2018-11-07" version="1">MLLALGNGPKSFRLARLTLQSPRRLSSLSFSFSASQPTMASTEAKPSRAAVTLKTPKGTRDWNGADMLLRDEVFKTITDVFKRHGGTPLDTPVFELKEILAGKYGEDSRLMYDLEDQGGELCSLRFDLTVPFARWLAMNNIQQVKRYQLAKVYRRDQPAIARGRLREFHQCDFDIAGVYDPMIPDAETLRIIVEVFDALDIGITIKLNHRKILDGMFSVAGVPPEKIRSISSAVDKLDKMAWPEVKKEMVEEKGLSEDVADRIGEFVRHSGTVADVVDLLRANEQLCANDDIKAGLDDMALLASYLKALDVMHKITFDLSLARGLDYYTGLIYEVINQPPKSDGNETQKKGKKDDPATQVGSMAAGGRYDNLVGMYGKRTIPCVGVSFGVDRIFTILKARREKEKTAKAPTIDVYVMAFGGKEFDGLLPQRMDVARRLWSAGIRAEFSPKVKPKLPQQFKAAEDAPLGVILGQDELAAGQVRLKVLGQADEEKDRGSLVELDDLAAEVKKLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L586</accession>
    <name>A0A367L586_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Inner centromere protein ARK-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_4027</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the INCENP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L586"/>
    <dbReference type="STRING" id="1330021.A0A367L586"/>
    <dbReference type="OrthoDB" id="6123at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005635">
        <property type="entry name" value="Inner_centromere_prot_ARK-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13142">
        <property type="entry name" value="INNER CENTROMERE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13142:SF1">
        <property type="entry name" value="INNER CENTROMERE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03941">
        <property type="entry name" value="INCENP_ARK-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inner centromere protein ARK-binding" evidence="9">
        <location>
            <begin position="1164"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="121"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="431"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="481"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1111"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="131"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="241"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="268"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="361"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="374"/>
            <end position="383"/>
        </location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="443"/>
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        </location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="495"/>
            <end position="508"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="516"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="538"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="552"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="622"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="632"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="660"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="716"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="744"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="772"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="798"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="833"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="866"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="924"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="940"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="969"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1005"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1135"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1166"/>
            <end position="1179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI09590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1276" mass="139916" checksum="3C0952D0ACAE2A5D" modified="2018-11-07" version="1">MSAMRGPRSQVGNASWIVDERSFASKIVNSEVEEFSYSARNELDWLNEHMAGIFDENETNLAETFKTPGKLRGKTPRTGRRPNELERVVSRFDSRIIGWKIDKEKPLSDVFSAKPREPLTLASPTRETGIPRSPARLLLSRLTASPAKQPNPLPPVQDSGYFGSQDVASLDVQHDLRPGNSQQLLRGEEDPCTPAMIPQRSPCRAAVPELHNEAEHTEEPPADSEENEAMPCSDDTRETQQESNENINATPPSTLEPHPDPNATEKGAASQTQEAEAQASQPEQVSDDGRSPSDGSSPIRPVVRKSSLTFASLPAREPLTAGKKMSVGTRASRTSHLDNIRTSYYNRPTGGKSLGNTTKADEDEMATGDEMGTDGEHSAKAADEQSNVPLNHTKTYTQRLQAQINLLGQSNVQPLQQHKLTATKTVSIKESTAVQSTPGAFPDPDDNGDDDDWIEPPASVAGTANGIPAFSKSRSADVMEAIQGKSTIGQEDFEAPERRADEDPKDGGAEQQVSRLLEHTDEASEKAVAETQLALDADSQSPQLAVSVSNPEMRDATERGRLYTPSKSPSRTFRDSPLKQVKNKLSSILKSSRGLLASSAAVSAEGKSSIMSPAAIRPVLHPTTSAESVVSKSHDELPDSHSQDEQPGSPGRPIARRTRASTEREKEEKRREKEAKRIEAQNDKLEKAREREREKALVFSREQERIAAMERQISSKKAEGKAASKETPKPTRSSPRRAKAVESEPNEDVEMEDAPVVPPQQSSAPHSFGPGRNKETKRPVRPAKEALAKAKQAPTVIRVNTGSQHSQFHTTNRLSTVSHDTTGSSSLQPQNRLLGKSSKASLHSKSSTSSMRAPSSVNRPRTLDLATKKKELEEREAQRRREARAETERKRAEEDQQKQERLRRQEADRQKQQHGSELAAEGKTPAERRAVLEKAKQTRAPPPAPRSQPNGPPEAQEKSASTIRGEAARQQSRVASTLLRSQEEQTRPVNGLLSSTTKSGVKRGLGTDRSDDNQAKRPPSRGGFSYQANEAKRRRTSDTFDDDAEIDHSRNIKGPPVRPSGGFKKDLAPKTMYGYTSASHSASRDLFKATVTAQHHGQTKAAHPLDMAQISKGGIPFAPNTNHGGAAYKTPARPGANPGAKSAAKSAARSSPRFQNGESIELPEIQTDDDDDDDDDDEGNGMNVAAWADSPDLRRALMRQETMDPSQIFGPPAPLNMEEVFNKSKERWHKFRARTSSANWAGADRLTEEDIRRDLAARDKLRREGGWSYEMSREMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L597</accession>
    <name>A0A367L597_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mob1/phocein family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_4029</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L597"/>
    <dbReference type="STRING" id="1330021.A0A367L597"/>
    <dbReference type="OrthoDB" id="10262609at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="269"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="391"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="392"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="404"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="418"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="436"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI09587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="457" mass="49936" checksum="596827108AD96B46" modified="2018-11-07" version="1">MAMAPSSPRLPSPPPPAEIQIGPKSPSGTTTVSPHAMRIEKSVIEAHSRRRIHPGTKAADMAAGPPLLDSAFQLQEHLAALHYHHTGLATQAVTRELALELAQPPPGIDRTLWLYELCRFLIAQCNSLIVGFLFDTPPCSADTCPEMRASEWQFLCAVHEQPKSCCAIDYCCHTLDWAANVVSDQKIFPSRFVALSDAHSKNVGLKNLINVFRRLHRIFAHAWFQHRDVFWNVEGQTGLYVFFKTVCDLYDLLPAENYKLPPEAEGIEAPVSEPELERPTPTILKPPSQQRGLDDDDGLHSVGRTNTRRHIRSSPSTGSAVTTVIETDEEDAETACNRMRDLRLAEQLQADDLEPDVVEVPVIVEQSDLIGAQDLDGPTITDVSLTAATVADAEEGEPADAEDDKPTDVPLEPKAEAAEPASESQPSSHLVPAEDSGSKEEDGEVPDKTLEAPATEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5D5</accession>
    <name>A0A367L5D5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_3987</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5D5"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017018548" description="Secreted protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI09646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="20501" checksum="9460D17991285486" modified="2018-11-07" version="1">MWSVLRLLPCVMAGLDTVPITPHTLCDGGTQCLDTSITHYVSAQRPRLAALYEKPSPSFHYLLDEGRLQLSSALSLPTSPSRHLPQPPTTITTTTASRTDGRAETASNKDKGKKGTQKTASEKGMARHQRVDRLCFFLIPCPSSRSLTLERRPLSKTCASQQRQEPFYLPQITQKLCTSSSSPPHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5F9</accession>
    <name>A0A367L5F9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 9">tRNA (guanine(26)-N(2))-dimethyltransferase</fullName>
            <ecNumber evidence="7 9">2.1.1.216</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_3803</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:43140"/>
            <dbReference type="Rhea" id="RHEA-COMP:10359"/>
            <dbReference type="Rhea" id="RHEA-COMP:10360"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74513"/>
            <dbReference type="EC" id="2.1.1.216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.216" evidence="7 9"/>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5F9"/>
    <dbReference type="STRING" id="1330021.A0A367L5F9"/>
    <dbReference type="OrthoDB" id="6349953at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160104">
        <property type="term" value="F:tRNA (guanine(26)-N2)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002940">
        <property type="term" value="P:tRNA N2-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.70:FF:000001">
        <property type="entry name" value="tRNA (guanine(26)-N(2))-dimethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.70">
        <property type="entry name" value="N2,N2-dimethylguanosine tRNA methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002905">
        <property type="entry name" value="Trm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042296">
        <property type="entry name" value="tRNA_met_Trm1_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00308">
        <property type="entry name" value="TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631">
        <property type="entry name" value="N 2 ,N 2 -DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631:SF3">
        <property type="entry name" value="TRNA (GUANINE(26)-N(2))-DIMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02005">
        <property type="entry name" value="TRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51626">
        <property type="entry name" value="SAM_MT_TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1 9" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="74"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="536"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="612"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="541"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="576"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI09659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="638" mass="70425" checksum="036368EB900C7A82" modified="2018-11-07" version="1">MTAADGPPAVEVNGNLYRPIREGKAIILVPQEAAAANGKGAANQQVFYNPIQQYNRDLSCLAIKAYGHWLQSQHVSRQANSRKRKRDQKDTLPPDDQSHGEPPEVKPKPLKILDALSASGLRALRYGHELPFAAAITANDLSASAVASIQRNVRHNGLQDVISVTNNDALALMYRRIADDLDKRDRHGNPAKGHKFDVIDLDPYGTAAPFFDAALQSVRDDGGLLCITCTDSAVWAGHSYCEKAFALYGGVPVKGPYSHEAALRLILHAVATSGARYGLAIEPLLSLSIDFYARIFVKVTRRQQAVKFNGVRTMLVYSCDQGCGAWETQPLLRTKPAPNKKGSGSFYKHGMALGPTADRFCHHCGFKMHVNGPMFAGRIHSQDFIQRILDEIPEAPPDVYKTLPRLEGMLRTAQEELIAELELRSDVDPLEAELAAVDGSPFFVVPGKVASIVSCATPSDDMFRGALIHLGYKVGRSHCRAGSIKTDAPWSTIWWMMTEWIRQKSPVKGSKFKPQTAAWKLLRDAGLVGEDAMDDAVEGSSLEKEGGRPAEETRKMEEEEEEEEEEKQAGVEEQTPADKEQPDDEARKPNHDEQALRKTLVFNEALARLGRRQTSQRCVRYQMNPEPNWGPMTKAKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L685</accession>
    <name>A0A367L685_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI09946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L685"/>
    <dbReference type="OrthoDB" id="4931002at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="222" mass="24504" checksum="33B9807A6F72C33B" modified="2018-11-07" version="1" fragment="single">QFLDQFEEKVQERRVDWLPFFVAPPCLRQIQVLTEDLPWPAAKTALLRYYGAFDQIRTVGFYEKLRRHEARRPKTKDTIDWLEKHAFLCRKIGSSYGPGPGPGPGPDESTEHSYGLFQALPKEIQVQLYDQLGQRPSSSPYGILHSHTHTQGTRPEGLGGSRDAGPAAAGPRPPYVTEAERHNNVGGGYGTATPYSGYGRTGRTGQQVKQGVPSSAIQSASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6D5</accession>
    <name>A0A367L6D5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_8653</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI09981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6D5"/>
    <dbReference type="OrthoDB" id="4903094at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI09981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="61" mass="7093" checksum="42AC99ACDB38EC23" modified="2018-11-07" version="1">MCTQVDKRWACGHIGFFHIKWCRKQFKGCKGPSAQHETVDDNEECSDCKRRFAVPQSYSPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6W6</accession>
    <name>A0A367L6W6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI09962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6W6"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="66" mass="7372" checksum="3632C3AC97B36197" modified="2018-11-07" version="1" fragment="single">MGSQSISSHHHCHHNTPLRPRELRSITSMKHALYHSSRAVANTPVLFTLLLCNSCPLNVETPAPHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L725</accession>
    <name>A0A367L725_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L725"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="97" mass="11333" checksum="58F47AA6A45B6E9E" modified="2018-11-07" version="1">MSWEKDKEENPSLVRKRYQLYPSSPCGIGDLRQPRQRAGPTEGWAEERGEGREEREDERRGKEDEKFVRHLHVIVCSVRCWAGLGPRAGRLREKKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L779</accession>
    <name>A0A367L779_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">2-oxoisovalerate dehydrogenase subunit alpha</fullName>
            <ecNumber evidence="9">1.2.4.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Branched-chain alpha-keto acid dehydrogenase E1 component alpha chain</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_8557</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 3-methyl-2-oxobutanoate + H(+) = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13457"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="1.2.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the BCKDHA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="9"/>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L779"/>
    <dbReference type="STRING" id="1330021.A0A367L779"/>
    <dbReference type="OrthoDB" id="3845at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003863">
        <property type="term" value="F:branched-chain 2-oxo acid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000015">
        <property type="entry name" value="2-oxoisovalerate dehydrogenase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050771">
        <property type="entry name" value="Alpha-ketoacid_DH_E1_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43380">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43380:SF1">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="11">
        <location>
            <begin position="94"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="404"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI10286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="536" mass="60443" checksum="70E7FC85695277AA" modified="2018-11-07" version="1">MKSRLLPTRPLQRAAFAPRLRHRRLSSSVSQRPNSDFVSFPGALKSAFTSSLKFEKPESYAALPTYRVVDQHGVVVDQAFEPDIPDEQIIKLYKDMLYISIMDLIMFDAQRQGRLSFYMVSAGEEAVSVGSSSVLDPEDPVFCQYREQGFFKERGFTTKEFMSQLFANKNDTGKGRNMPIHYGAGRLNIYTVSSPLATQMPQASGAGYALRMQRMQDANAKPRVAVCFFGEGAASEGDFHAAMNMAATRSCPVLFICRNNGYAISTPTLEQYRGDGIASRGIGYGIDTIRVDGNDVWAVREAVKRAREMALHDGGKPVLIECMTYRVSHHSTSDDSFAYRARVEVEDWKRRDNPITRLRKWMEARGCWDEGKEKEARDGLRREMLQGFAEAEKEMKPALRTMFEDVYEEMNDDLRQQMARLREMLDQYPDEYDVAEFEGGKESLKPPTAAGPRGYHFPPCTTVRYEDSPHCRVASPRQRLRRVLTVLALAPASSPNLRLASPRSSPKEAPANAGTARFTIATIVELEARFDRPIVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7W7</accession>
    <name>A0A367L7W7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Clathrin/coatomer adaptor adaptin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_4449</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7W7"/>
    <dbReference type="STRING" id="1330021.A0A367L7W7"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030123">
        <property type="term" value="C:AP-3 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026740">
        <property type="entry name" value="AP3_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037096">
        <property type="entry name" value="AP3_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="7">
        <location>
            <begin position="67"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="581"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="734"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="760"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI10523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="807" mass="88205" checksum="16C1E934FD5A3B58" modified="2018-11-07" version="1">MSSSDRHACCRAHPEKETLSSFARRRRTAGMESVARISGLMETARELTLDAAQATRGARAGSRPLDRTQMKKLLDSRNDREVLEGLRRVVSMMYRNQKTLPFFSSVVKNVASPSLEIKKLVYIYLIHHAEHEPDLALLSINTIQKSLSDPNPQVRALALKTMSGIRVPVISQIVALAIKKGIADMSSYVRKAAALAIPKCYRLDPGQSPQLIECLATLLGDRQFYVAGAAVSAFMEICPTRIDLIHKHYRSLLRKVVDMDEWSQLSLLRLLAHYARRCFPRRSRPSGSSPAPAVDEFYGEAPANTHEDGAGVASLDPDLVLLLNSIRPLLQSRNSGVVVAVTRCFVDVGTPAYVKLSVGPLVALLRGPRDIQQIALYNIVSVCLAHPGDFVKYASHFLVRATDSPPIWELKLELLTIIFPHSPSHIKSLILKELEHFSRGSSKALVREAVRAIGRCAQSDIATAPRCLKLLLSQIASLDGTLAAESLTVIRHLIQQDAEAHIGTVVRLAKNLDSATDPQARATIIWLVGEFSGLNGEDNIAPDVLRILVKDFASESEPAKRQILLLAAKVYLHHLNRTAAATTTTDEQREAGDGDPSSSTQTKAHPLSRLWDYVLLLVRYDSSYELRDRARMYRSLVGVPQLATLMLLAPKPAPQAPIPSESRRGFHLGSSTLVLAGAGGVHGLRGYEPLPDWVPAGEEPAAKLRDQEGGPWRADASASSTVVSASERLDDAAAVASRTTPSTGLNGLVEGVGAKSLDDWLAEGEDDELDDEESDDEETDDDEEEESDDDDDDDDDDAGEKTRLTKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8V2</accession>
    <name>A0A367L8V2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8V2"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="223"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="515" mass="57968" checksum="E3010E28171EA4BA" modified="2018-11-07" version="1" fragment="single">MQSALYVFAKYTFSTRPEGLGGSRDAGPAAAGPRPPRRLRHGYAVQRLRPYGPYGPYEGRNGVVFPPPKLVTETGGLSGVFFFSTMLRYSFALRSRLQRQQRQQTQKDHLITGCQEGGRTRGPRQQTSRPSSSFLRQGSQRPIPRSFFSTFAADTATATATANALVATVPLLLFLSLSNALFDPIFSAAFFVLWSSVLFFPPSSSYGRPYSLQRRQERDQDQDQGQDQQQNTGTSREQQSQQPLRQPLQQEQRQQTIVPTAVPYLRPPQSLPSSSYSSSSSSLPESFVVLFVFFFVFSFLRPYPPPTTFSRKGNSAVPRSIRGTGPGSKSRLATFLRAPPCLRQIQVLTEDLPWPAAKTALLRYYGAFDQIRTVGFYEKLRRHEARRPKTKDTIDWLEKHAFFCRKVGPGPGPGPDESTEHSYGLFQALPKEIQEGHVTPGRLQPARGRRTSQRLRRLRHGYAVQRLRPYGPYGPYEGRNVGTGQARRAFFSNIISLRRLRPYGPYGPYEGRNVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9D6</accession>
    <name>A0A367L9D6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycosyltransferase family 32 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_5181</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI11038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9D6"/>
    <dbReference type="STRING" id="1330021.A0A367L9D6"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051999">
        <property type="term" value="P:mannosyl-inositol phosphorylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051706">
        <property type="entry name" value="Glycosyltransferase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385:SF15">
        <property type="entry name" value="INOSITOL PHOSPHOCERAMIDE MANNOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI11038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="36028" checksum="2CE4F4161E8514DC" modified="2018-11-07" version="1">MAILVRWGSRKVIALLLLALSAVVVIHQLTYISDVDLANRLPESLNVIKECSSKDDHQGGIPKLIHQIWKTSNVSSYPIEATHAAWKAMFEPRNYTVKLWAESDIVDLIEAKYPWLLSTYQAYSQNIQRADVARLLVLHAEGGIYADLDVHPISFDELSCWRRLNLQALFAPTSGTSGISNHFVMAEKGTAFLQWALHEAKRRGGPSSRHILFPYLQVFWSTGPLMINSALRSYASHMGQADKPVGVAEEGYCGSVLWHAAGRSWHKSDGRLLNYVADRVGVESSYMVVLACLVLLGLAVFTARRYLKVAASRDASLSPILNKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9I4</accession>
    <name>A0A367L9I4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">aromatic-amino-acid transaminase</fullName>
            <ecNumber evidence="9">2.6.1.57</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_7321</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an aromatic L-alpha-amino acid + 2-oxoglutarate = an aromatic oxo-acid + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:17533"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:73309"/>
            <dbReference type="ChEBI" id="CHEBI:84824"/>
            <dbReference type="EC" id="2.6.1.57"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.57" evidence="9"/>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9I4"/>
    <dbReference type="STRING" id="1330021.A0A367L9I4"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047536">
        <property type="term" value="F:2-aminoadipate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008793">
        <property type="term" value="F:aromatic-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009074">
        <property type="term" value="P:aromatic amino acid family catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000074">
        <property type="entry name" value="Aromatic amino acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF21">
        <property type="entry name" value="AROMATIC_AMINOADIPATE AMINOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="11">
        <location>
            <begin position="222"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI11085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="572" mass="63527" checksum="AD8C0A513B9D2BE9" modified="2018-11-07" version="1">MLTVIRAAGRHPRLRLSAAGCLLRRWSHDDVSSARDSLSNAEAAPTASPARLERQQTSSALDDVLARRVRAGRLVAGVAAASHSDMFKGPQNGKPKARRWGEHLTRESLDRQPCSLKQAAKFLKKPGLVSLGGGLPSSELFPFAELAVRVPVAPGFSEKETLENGQTMTIGKYDARDRGAAYDLSIALNYGQSTGSAQMMRFLTEHTEVVCNPPYADWRICQTIGSTGALEQALRMFCDQDRGDSVLTEEFSFSTALETIAPLGVKAFGCAVDDEGLVPHSMDRLLSNWDQAVRGARKPHLLYTVPCGQNPTGATQGAQRRQDIYRIAQKHDMFILEDDPYYFLQMQPYTGRDSADVRAPRSVDEFLSSLLPSLVSIDVDGRVMRLESLSKVLVPGSRLGWVVASEQLIERYQRHAEVASQGPAGFSQVILHKLLDETWGHEGYFRWLMNLRLEYTKKRNALLAACEDHLPREIVSWNPPSAGMFMWLKVDYDKHPNAGTRSIDEIEEDIFRACIDGNVLVARGSWFKTDKDKPLPGLHFRTTFAASSPEAMNEAIRRFAKAVRDSFCMSPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9K4</accession>
    <name>A0A367L9K4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_7518</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the peptidase C12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="8"/>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9K4"/>
    <dbReference type="STRING" id="1330021.A0A367L9K4"/>
    <dbReference type="OrthoDB" id="1924260at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.532.10:FF:000010">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF16">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52049">
        <property type="entry name" value="ULD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="10">
        <location>
            <begin position="207"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="72"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="357"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="357"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="393"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="7">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI11110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="600" mass="66151" checksum="92FEAB85C2EDB265" modified="2018-11-07" version="1">MARRQNDPAGPGVAEPAASTATEQAIEIMAERVAEKAVIKVLDALSDRYVDALAEKLPAGIIDKIAASVAEKIAAAASAPEKQEEAGIPKRENGHDNKPPELAPPQTRSTRGGRQARKRRSPEHDDAPPEKKSRTARKARKEDTETTFTEGRSTRSRAKKANDVEAGKKAEGNTTDQDLAEDDDNSDNLLVETMKPLDDKDIEEWAGWAEVESEPAFFNFILKKFGVGGVTVRELVSLEHWALAFLPQPVYGLVFLFQYAPQLADEEDDDSGEAPVWFANQTTNNSCASVALLNIVMNANVELGQRLQSFKESTMDLSTPMRGNSIGNNSFIRTAHNSFVRRMDQLNADLCLANEADAHSPKEPRAKAAAKKTKPTDKSEVKQASSEVDYGFHFIAYVPAGGFVWELDGMRIRPRNIGALDTEDWTAIARPRIQHRIKEYGETEIAFSLLALCRSPFLAHGDTIASNLAALHRLRKAYADDATFREVVEAHPHIQMLDSEDALADFGLDASDIADAQLPAQVQQQMQADKFGSEQARNLFPELAADVQVAMAKYREELVAVAEEEDRVHSRKKDYSPALHLWMTKLAEKGVLEEVIGNSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAA2</accession>
    <name>A0A367LAA2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Tetrapyrrole biosynthesis uroporphyrinogen III synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAA2"/>
    <dbReference type="STRING" id="1330021.A0A367LAA2"/>
    <dbReference type="OrthoDB" id="5595751at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00320"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004852">
        <property type="term" value="F:uroporphyrinogen-III synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006780">
        <property type="term" value="P:uroporphyrinogen III biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06578">
        <property type="entry name" value="HemD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10090">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036108">
        <property type="entry name" value="4pyrrol_syn_uPrphyn_synt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003754">
        <property type="entry name" value="4pyrrol_synth_uPrphyn_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039793">
        <property type="entry name" value="UROS/Hem4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12390">
        <property type="entry name" value="UROPORPHYRINOGEN III SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12390:SF0">
        <property type="entry name" value="UROPORPHYRINOGEN-III SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02602">
        <property type="entry name" value="HEM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69618">
        <property type="entry name" value="HemD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tetrapyrrole biosynthesis uroporphyrinogen III synthase" evidence="1">
        <location>
            <begin position="26"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="320" mass="34916" checksum="142C86D9CBF7FBBC" modified="2018-11-07" version="1">MASPPPQDARTAVAILLKTPSSPRDPYEEQFQSSNLSPYFVPVLRHQSCVDACSRLEELLLRRRIGDGPDCLFGGLIVTSQRAVEALASVVEAGRHRRRHGAEVDEAVPSSPSSKSWPHLDDVPVFAVGPATAKALKNIAPMCVLGGVECGNGESLARYIQARYRVSHGRPLLFLVGEQRRDVIPRTLMDDSLPPARRIQVIEEVVYTTTVVPDLVQDLDLALRRSADSPVRWIVVFSPSGCDSLLRSLGWIDEATGKAWPPASMTTNGGTLIVTIGPTTRAHLMDTFDFEPHACAATPSPEGVLKAIEQYMRHEVARSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAV2</accession>
    <name>A0A367LAV2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cx9C motif-containing protein 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_7341</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CMC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAV2"/>
    <dbReference type="STRING" id="1330021.A0A367LAV2"/>
    <dbReference type="OrthoDB" id="13601at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1130">
        <property type="entry name" value="CytochromE C oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027179">
        <property type="entry name" value="CMC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15590">
        <property type="entry name" value="CX9C MOTIF-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15590:SF0">
        <property type="entry name" value="CX9C MOTIF-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08991">
        <property type="entry name" value="CMC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI11545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="72" mass="8641" checksum="AA1699787BAEC5E1" modified="2018-11-07" version="1">MSRLTRELEQCAIQECLSRNNYNEAKCRDAVKALYDCCQRFYNRYGDDAQTPSCPRPELLHLKLEQHKRQQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LB95</accession>
    <name>A0A367LB95_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Low affinity iron permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LB95"/>
    <dbReference type="STRING" id="1330021.A0A367LB95"/>
    <dbReference type="OrthoDB" id="2224262at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007251">
        <property type="entry name" value="Iron_permease_Fet4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04120">
        <property type="entry name" value="Iron_permease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="407"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="496" mass="55054" checksum="51B250106EB559B1" modified="2018-11-07" version="1">MKRTTTATAAAAATFSTKRLLALLASYGAKGPIEHAAPTQRVKQGCSNITGYADKAKDRALDRWLDRVVKASGSEPVFLFIVVGLVTWAFLGIPYSHTADWAVIISDVQAIVSYVFDSLLMRQQLNEYEKMVRVSASLRSRAISNRRMLRELVNDGRRLCQQQQQQSSTTCEEALPRETVVDRISTAASKTVGHLAAVCLYWACIAIWLGFGPWEDWSNSWQLAINSATSALMVFIFAFLANVQERHAAHTERCLQAIFEHDSAVERALRAMTGDDVANETVVVVAPRMSRIQRAILYYADLVGTLTGIAILTAVMVVWLAIGPIMGFSSNWWLLIGTYAGLVGLNDSFVLRNVQMLFNGYAQEALDQVDLDDKSILDQLRLSDPAAQTAEQQQQQQQQRGSVSYRISAWMGVVCAHEATVVVGFVFILGLLAGASAMRWSTAGQLLCNIPPSIIETFFMMILITGHNQAETKRHQRLETFFLRRSMLLSHVQRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBB5</accession>
    <name>A0A367LBB5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TAFII28-like protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_7630</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBB5"/>
    <dbReference type="STRING" id="1330021.A0A367LBB5"/>
    <dbReference type="OrthoDB" id="28335at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08048">
        <property type="entry name" value="HFD_TAF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045127">
        <property type="entry name" value="TAF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006809">
        <property type="entry name" value="TAFII28_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13218:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13218">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04719">
        <property type="entry name" value="TAFII28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016652933" description="TAFII28-like protein domain-containing protein" evidence="7">
        <location>
            <begin position="18"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="TAFII28-like protein" evidence="8">
        <location>
            <begin position="494"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="25"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="274"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="569"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="52"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="110"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="287"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="362"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="375"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="392"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="430"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="569"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="579"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI11701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="634" mass="66297" checksum="3210A9BEB244F8C6" modified="2018-11-07" version="1">MKVTATIVAVLAGSAFAHVASDARSGVTSRSVVAKTESKRSAAFDMAPGEMFYKRAEEGKKEEGKEGRKEEGSEKKPSNTGEREGKEGGAEKKPSKNGGAVAPQQGGGRPSREKPGEKSGENAGEKSGEKAGEKSGEKAGEKSGEKAGEKAGEKTGEKAGQKTGEKTGEKAGEKTGEKTGEKTGEKTGEKTDEKTDEKAKEAKEKAEKARKEAEEKAKKEAEEKKAEGAQKKEASLLLNRISVPGPHSQFLGLTVSSWASQSVPGRLLHSIGRLKKSQRMASPPYGSPALALSPPNPSAAQLPNKKRSSPLDVGAPPPVKRRKPSSLSQSSSAATPAHPLRQTSFPPEASSPHAARSPSLDAASSAVSGSAVSAARKKRPAGRKSRASRVGATASASAAAAAAAAAASASAASAATGGGQDAGERTPSLVGGKATATVGGAEKDPPAATGAGPAAAAAAAAADDEEDEKEELALEDVVARTQEQKQEEIRLRAMLVEAFDAEQYNRYEMWRAAKLSDAVVKRVVNATVSQSVPQMVSTAVKAVAKLFAGEIIEAARKVQGQWIAAGEVQSEEVEADKDDGDRRGPLRPDHLREAWRRYKMSGESHGVGMQQLWHAQRHDGVDRFSTRTQRRIFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBJ2</accession>
    <name>A0A367LBJ2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7424</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBJ2"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI11793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="104" mass="11860" checksum="18A5E665CF686066" modified="2018-11-07" version="1" fragment="single">AIAQSSRPKRKPLPPRLLFDGDKILFLAHFLKSYNLYLARRLSTLRMRFVDIFLATSLREILLALYITPTLKAPPIISLLSKVSNFANFFSKEKASALPPYYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBM5</accession>
    <name>A0A367LBM5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Gas1-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBM5"/>
    <dbReference type="STRING" id="1330021.A0A367LBM5"/>
    <dbReference type="OrthoDB" id="3241054at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021476">
        <property type="entry name" value="Egh16-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34618:SF3">
        <property type="entry name" value="GEGH 16 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34618">
        <property type="entry name" value="SURFACE PROTEIN MAS1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11327">
        <property type="entry name" value="Egh16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016918473" description="Gas1-like protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="26763" checksum="944C378E52ACDFE9" modified="2018-11-07" version="1">MHSSHVTVLASFSYLHWALCHGVILAAQGNTGSPASVGFQVNPDVARDCIGINPCQQDTTIIRDAEIKQNIVNECGRTQLNGNIDVGENTEKAIAAKAVTQVQSGGQVQLTLHQVNADGAGPYVCDLDENSNSGTISPKNVTVLNNVPGDNGLSLAKTQQFNMTIQLPADLQCTGASTGNICTVRCRNTAAAGPFGGCFPVQQTDITPKVNTPANINTSQPMELISKQIESNRANFGPATEANNRLHAGQPDDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBU0</accession>
    <name>A0A367LBU0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_4185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000009">
        <property type="protein sequence ID" value="RCI11887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBU0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016685977" description="Secreted protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI11887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="102" mass="11332" checksum="775C1D7A5C540154" modified="2018-11-07" version="1">MLTRRLIVLLKKARLACSLTYPTFLPSYGPYGPYSRSRSRSRSRSRSRSRSRLLRCCAVPTSVTFLPIVVTYSRCDVRRPRAGCSRPGVTVSGAPAKLLPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LC25</accession>
    <name>A0A367LC25_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">glucose-6-phosphate 1-epimerase</fullName>
            <ecNumber evidence="5">5.1.3.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_4586</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 6-phosphate = beta-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:16249"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58247"/>
            <dbReference type="EC" id="5.1.3.15"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glucose-6-phosphate 1-epimerase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.15" evidence="5"/>
    <dbReference type="EMBL" id="LKCN02000008">
        <property type="protein sequence ID" value="RCI11979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LC25"/>
    <dbReference type="STRING" id="1330021.A0A367LC25"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047938">
        <property type="term" value="F:glucose-6-phosphate 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09020">
        <property type="entry name" value="D-hex-6-P-epi_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000061">
        <property type="entry name" value="MFS sugar transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025532">
        <property type="entry name" value="G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF68">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="106"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="421"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="20"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI11979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="862" mass="94677" checksum="0843473EC65E73BE" modified="2018-11-07" version="1">MASSDGYLLGLRGKGLNWAIGAVAGCDFLLFGYDQGVMGGILTLPVFLDQFPDINDKDPTIAHDHALQSRRSTYQGIAVASYNLGCFVGAVITVFVGNPLGRRRVIFFGTALMVLGAALQASASSLTHFIIGRVITGLGNGANTSTVPMWQSETCAAHKRGKFVMIEGALITGGIMISYWVDLGLSFVPGSAAWRFPLAFQVVFCIFILALVFSLPESPRWLVLKGRDDEARRTIAAVADVDEQDKYVENELLAIKTTVEEMSKGTYADLFARDRNRTLHRTLIAYVNQMFQQVSGINLITYYAAKIYSDLGMSPFLSRLLAALNGTEYFIASWPAVFLVERVGRRKLMLFGAAGQAATMAILAGVNSRPNDKACQVAGIVFLFVFNTFFAVGWLGMTWLYPAEITPLRTRAPANALSTSSNWIFNFLVVMITPIAFQNIQYKTYIVFAVINAFMVPSVYFFFPETAYRSLEEMDIIFQKVSGWRGAFTVVEQARVEPRRHGKNGELLLQVDQEVEGNLPAAMDKHNGNKTMFTALSPLVEEMGPDEIGPNKPSALASTPGLPPQAHFSIADDGSRVTARLHTGESVDVLLYGATVISWKDATGSEKLWLSQGSKLDGSRAVRGGIPVVFPLFGPPVASHMATCKLSQHGFARSTRWEFLGKSTSEGDPSSSVKLDFGLSPDNLDDATRALWPYKFGLLYSVTLERESLNTTLVVTNQGEEPFEFQTLIHTYFKVDDISSVHVTGLEDSFYLDKTDGGKEKKHASDPVTFSAEIDGVFTPAKGPNHPVVISEAGKQRFRIVRDNLEQIVVWNPWTEKAEGMTDFMPKSGYKNMVCVEAGSVRGWQKLDKGDAFEGAQTIWLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-09-13" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCC7</accession>
    <name>A0A367LCC7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_0086</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCC7"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017074297" description="Secreted protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI12083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="82" mass="8387" checksum="2D031E0CAD3E6AB0" modified="2018-11-07" version="1">MKFTLVSLFALVAMVMANPLPGSGLVVRQEQEQNANELDEGSQEPQVNPEDIADAVPVEEAAMSDGGGEVTAYNAAGPGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCM3</accession>
    <name>A0A367LCM3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCM3"/>
    <dbReference type="STRING" id="1330021.A0A367LCM3"/>
    <dbReference type="OrthoDB" id="5335351at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024526">
        <property type="entry name" value="DUF3807"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40642">
        <property type="entry name" value="YALI0F31295P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40642:SF1">
        <property type="entry name" value="YALI0F31295P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12720">
        <property type="entry name" value="DUF3807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="276" mass="31028" checksum="7054CDAA099B57A0" modified="2018-11-07" version="1">MPSSCASQNGDPPAPEPQDEGGATKQSQPESRTPEKQVDRGDGPESDSPGQLAPFDWADFEARYEKALREADAHEREILKEAQHLSTTWASAAAAHDDERAVKRLRTRQRFVNLSEEKVAQKQQHCGLHNNDLSGFFQSHFAAAAVANFDHKFQDLLALHQLQGARPQQSASADDDDGLGYYADGVKRTLTDEQIEIFRQSELRELLREQQPAVAERPKPDEADEAVEHRSSTRGVKRKKKGKYNGTSKPRYEPKPDLRKRTWDVVEPGLDTLDYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCR8</accession>
    <name>A0A367LCR8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCR8"/>
    <dbReference type="STRING" id="1330021.A0A367LCR8"/>
    <dbReference type="OrthoDB" id="4926920at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="288"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="376" mass="40106" checksum="8AA4E12E725F7660" modified="2018-11-07" version="1" fragment="single">DGINFIPDNLKWFGRDLARFSGCFLQRAWNNAKHVQCGGCTAGCSPGGVDKSGDPQNNIISCVCANKDRLALYWSQDFTACVTKKHILGNGVHNKIIRELGAGRVTELWTTDIGGLGLSYLCGEYEADDDYTPSYGPTAKTFRRAIEDLLPDEGGKLDNISPDKYDKPAEETPEKPEGKKDKKGKKDKKGGKKGTSPNYILFKRRWRLLRRRDVYTSGNYAGGDIYTAGNYGSDSKETTYGPNTFVTGYKADGNTYGAGSSYDAPKSSYDAPKSSYDAPKGSYGGGESSYTTTSYEAPKSSYGGSTGYKSEKGYEAPKSSSYGGGSSSTGYKADKGYEAPAAYGGGESTTSYGGGSSTSYGGGSAGYKAEKGYEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDR2</accession>
    <name>A0A367LDR2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_0330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDR2"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI12565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="64" mass="7242" checksum="5ACDBDA9A5DABD25" modified="2018-11-07" version="1">MPSTPWPLLLHLPVGDKPRPKLETDLASYFRIAVSSFDDLACTARGPLFCDPYLKRKLDTELKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LE21</accession>
    <name>A0A367LE21_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_0556</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LE21"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI12661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="70" mass="7517" checksum="613416328D260A2F" modified="2018-11-07" version="1">MKVRLERAGGSIFATGAKVSVPAELTACLTASFDLGARHGCGSGTNRDKWSYRVMGPFMQQQPVSVRELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEJ0</accession>
    <name>A0A367LEJ0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Yippee domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_0972</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the yippee family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEJ0"/>
    <dbReference type="STRING" id="1330021.A0A367LEJ0"/>
    <dbReference type="OrthoDB" id="6407410at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034751">
        <property type="entry name" value="Yippee"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004910">
        <property type="entry name" value="Yippee/Mis18/Cereblon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039058">
        <property type="entry name" value="Yippee_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13848">
        <property type="entry name" value="PROTEIN YIPPEE-LIKE CG15309-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51792">
        <property type="entry name" value="YIPPEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Yippee" evidence="5">
        <location>
            <begin position="62"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI12837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="229" mass="25272" checksum="EBE0B7D15796AA8E" modified="2018-11-07" version="1">MMPRESRISATRPVFPSFLLPSVGFGSLRRRRDVDDPPTAGEPAYGTRTATAAGRLRRVSPDTLRCMRCSTDVALASHIVSKGFTGRHGRAFLVTPPAPPAEQTLANIRVGRSEDRQLVTGWHVVADIFCATCSRKLGWKYVDAKESSQRYKVGKYILEVERVVTHRCWEDEDGPAPSMSPTAAAEGDIVFDSDDDDECEDLFNGVWTASGAAKRRRQSVVRRLSSMAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LF04</accession>
    <name>A0A367LF04_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA replication licensing factor MCM2</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">DNA replication licensing factor mcm2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Minichromosome maintenance protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">L249_0544</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LF04"/>
    <dbReference type="STRING" id="1330021.A0A367LF04"/>
    <dbReference type="OrthoDB" id="844at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006279">
        <property type="term" value="P:premeiotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17753">
        <property type="entry name" value="MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000002">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1640.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001141">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008045">
        <property type="entry name" value="MCM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF44">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12619">
        <property type="entry name" value="MCM2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01658">
        <property type="entry name" value="MCMPROTEIN2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="20">
        <location>
            <begin position="495"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="132"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="707"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="714"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00074927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00078186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RCI12812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="904" mass="100221" checksum="F928E5EFA6F7CEDC" modified="2018-11-07" version="1">MSSPPPPLRDNPASANRGLPPRSSLKRARDDGASPADLGSSPMPSSPPAPFNMAHGADDDDEIEEEAEIQDDIDDVDEMADDDIDLFREGYENDYADREGDAYEGEDIDDEGHYNALDIGSRRRLEAQLNRRDREVARRQRIPAAFLPGDDDDDDEGEDDLDPSAQPRRRRHHYDEDVDDAMDGDIMDEELSLEALGDVKASNLTEWLALSPVQKTIKREFKAFLTSYTDANGESVYGNRIRTLGEINAESLEVSYNHLADSKAILAYFLANAPSEMLKLLDEVTMDVVLLHYPDYELIRSEIHVRILDLPVHHTLRQLRQSHLNCLVRVGGVVTRRTGVFPQLKYVKFDCAKCGVTLGPFQQENNVEVKISFCQNCQSRGPFAINSEKTVYRNYQKLTLQESPGTVPAGRLPRHREVILLWDLIDKAKPGEEIEVTGIYRNNYDAQLNNRNGFPVFATVLEANNVVKSHDQVAGFRLTVEDEHAIRKLAREGNIIDRLVHSMAPSIYGHQDIKTAVALSLFGGVAKTTKGSHHVRGDINVLLLGDPGTAKSQVLKYVEKTAHRAVFATGQGASAVGLTASVRRDPLTSEWTLEGGALVLADRGTCLIDEFDKMNDQDRTSIHEAMEQQTISISKAGIVTTLQARCGIIAAANPLGGRYNSTIPFAANVQLTEPILSRFDILCVVRDTVEPSEDERLARFIVGSHGRSHPLSSAAETPAAAAATTTTTAPDSMEVEHASVPTGESGRQQQQPAEIPQSLLRKYILFARERCNPKLYHMDEDKVARLFADMRRESLATGAYPITVSVLPAFVMARKTRAKLTRHNQVRHLEAIIRISEAFCRMRLSEYCSSQDIDRAIAVTVDSFIGSQKVSCKKALSRAFAKYTLARPSSTTNTRPRGGARSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LF92</accession>
    <name>A0A367LF92_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Histone-lysine N-methyltransferase ASH1L</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_0193</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LF92"/>
    <dbReference type="STRING" id="1330021.A0A367LF92"/>
    <dbReference type="OrthoDB" id="422362at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.270.10:FF:000037">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006560">
        <property type="entry name" value="AWS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050777">
        <property type="entry name" value="SET2_Histone-Lys_MeTrsfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22884">
        <property type="entry name" value="SET DOMAIN PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17907">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51215">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AWS" evidence="11">
        <location>
            <begin position="329"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="9">
        <location>
            <begin position="387"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="10">
        <location>
            <begin position="511"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
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            <begin position="175"/>
            <end position="219"/>
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            <end position="548"/>
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    <feature type="region of interest" description="Disordered" evidence="8">
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            <begin position="610"/>
            <end position="718"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="64"/>
            <end position="75"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="183"/>
            <end position="201"/>
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            <end position="696"/>
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            <begin position="701"/>
            <end position="714"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
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            <dbReference type="ARBA" id="ARBA00022679"/>
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            <dbReference type="ARBA" id="ARBA00022691"/>
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            <dbReference type="ARBA" id="ARBA00023242"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
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        <source>
            <dbReference type="PROSITE" id="PS50868"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51215"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="RCI13086.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="810" mass="88290" checksum="981A5175FDECB0A9" modified="2018-11-07" version="1">MSLADASSSNLASSSSSSSTPPTTIADSASLASEKLDVITVASPLRRRSGRVSGSPAYNPSRLSRTDSHARRRSDITPTTTVTTTRTRRLTRQSLDGHDSSSAPSVPAPPAPTALAAKLSALAAAKPSSSALGKRRRDTSLLSRELRRLQDTNEFAGIDDRPVIHTVWSNGKYVDPAEQQQRPSPPPPPPPPPPPPPPPPAAVTAATPDAVRKHEPVTKVRVKRYLDKGLYAGQDLPRDPTKGLTPAEKKKLSQLPELRVSSPHNTVMPMPIYNGLRTLIAGRDFKLPYNVCHPLPPGQPKPDEWKKMTKNRFIGHSKEYWRKMPHLHDYQSKCVCEPQDGCGESCQNRIMLYECDATNCNVGKDHCTNRAFADLTARRAKGGKYRVGVEVIKTADRGYGVRSNRCFRPNQIIMEYTGEIITEDECERRMNDVYKDNECYYLMSFDQNMIIDATTGSIARFVNHSCNPNCRMIKWIVSGQPRMALFAGDRPIVTGDELTYDYNFDPFSAKNVQACLCGEPNCRGVLGPKPREVKTAKTDPSKVGGSKVRPSIKAAAAVVKPVVGAAVRAGKRKLKELMGDKESQGVDEKPAAKRMKCLAVAGRLGNKEAASSLLNKGKETEKKEKTKKATTWPLNNKKKTTTCSKKKNATSSVNESKDKKTAPMRKKVPTSPTKTTTATKSANRAVSTTIKVTNTGGKAKASSHKVTKTVRRKAAAASVPMKTRLVLKRKNKVISTTTTTCEEQGRSPRTSSPTTIVAKAGELIHGPAVEGVAGGDEMECEMEKNKTDDSVLKSVEAETKMEVEAIIVTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFC6</accession>
    <name>A0A367LFC6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">L249_0054</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 14">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFC6"/>
    <dbReference type="STRING" id="1330021.A0A367LFC6"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902181">
        <property type="term" value="P:verruculogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23954">
        <property type="entry name" value="AMO1_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
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        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041367">
        <property type="entry name" value="Znf-CCCH_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF237">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ATNE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18044">
        <property type="entry name" value="zf-CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 14" id="KW-0349">Heme</keyword>
    <keyword evidence="11 14" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8 15" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="18">
        <location>
            <begin position="578"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="15">
        <location>
            <begin position="578"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="542"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="603"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="768"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="731"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="554"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="606"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="801"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="821"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="852"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="877"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="920"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="933"/>
            <end position="949"/>
        </location>
    </feature>
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        <location>
            <begin position="956"/>
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        </location>
    </feature>
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        <location>
            <begin position="978"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="458"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RCI13111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1254" mass="136851" checksum="C641EDA1BE06EA3F" modified="2018-11-07" version="1">MTMMMMSLHCWSLLTVLLAGGVLWSFAIAVYRIFFHPLAKYPGPLLAKVTNIYQLYYAYRGDRHLEFWRMHQRYGKIVRFGPNAVSFNSNQALKEIYGFRSNVRKADFYDAFVHPAANTHNTRDKDTHARKRRVLSHAFSDSAMRAMQRYILANVRTFCEQIGVQDGGAESKGWSRPRNMTDWCNYLAMDILGDLSFGKAFHMLEQPDNRFALDLVEAAASRHLICGTMPVVDRLKIDRLLFPKLAAGRARYMAYSKSQLTERTKLGEETDRRDFFYYLLKARDPETGLGFSTPELWGESNLLIIAGSDTTSTAMAATLFYLVRNQPALERATAEVRSKFQQVEDIVHGPALGSCTYLRACIDEAMRLSPSVGGILPREVLAGGISIECQSLPAGTVVGTPHYAIHHNQDYYPMPFSFAPERWLVGETNPITERVTTEDDLATAQSAFCPFSVGPRGCIGKGLAYVEMTTALARTLFMYDLRRAVGVEDPGEGRVGAEWGRHRVDEFQLRDTFTSAKNGPMVEFRRADMFFASQLRSLLHTPPSHRPPSPFFHHQNRNHHHHHHSPTASRHAALKPILPDMAVCRFFQQGNCKFGNNCRFEHPAPRSQSQPNRFSALSSATSSAGRGPQAELLGKTQSPSSPTRTRTMDAQLTCIAAKYSISAEAITRDLTIDKPPWILSAYAPGREAPEQLFGGFPREQSFEEVKLHYMLGKASGNEQQAVGDSHSPLKLNEAQQLYRTAEQQIENALKNIDAAANFVAEAENRHPNRHDICRNGTQGAPFGQFRIGRQPKPLGNPSPLSNPFAGSSPSPSSNPFGQPSAAQSNPFARASQPSTSPFGQPSQTGGAGAFSQAVQPTSAFGQPTALGPKPNPFAASSAPQPNAQGNTFGVTSQLGHKTNPFAQVNSATSPFASLPAGDNAAAARSPFSAPAPQTNTTANPFSTHQNNSAGGAFAPQSGSFASAGQPQAQGTGRPFAPQSGSFASAGQPQAQGTGRPFGQTNGVFGQPATNNNVAQQPNPFGAPAAQQQPRRPSEMATTGPYPPGSTKSHPPLGSYCSRDASGRLTAFKGKPVAYNQGLPGTRGFDGTWTRIWFPDGPPMYSRDTELPQQQYDEKSMGQWEAFAKTGAFADGIMPELPPPRECTLSDEVRREWNIESVGLTVARLGIECAASEISTQAAATLLARHSLRLGRSMIHHVHQEAIDPPPIALKVETIKSVVTHPISSSDSDFDLDTGIDVDDNLLNYLGRGVQAADR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFJ0</accession>
    <name>A0A367LFJ0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Small EDRK-rich factor-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_0366</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFJ0"/>
    <dbReference type="STRING" id="1330021.A0A367LFJ0"/>
    <dbReference type="OrthoDB" id="18018at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007513">
        <property type="entry name" value="SERF-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04419">
        <property type="entry name" value="SERF-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small EDRK-rich factor-like N-terminal" evidence="2">
        <location>
            <begin position="41"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI13193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="100" mass="11276" checksum="AD53522C69F6F618" modified="2018-11-07" version="1" fragment="single">FLLLQNQRPFRHPHTIEVKDIKKRQPSEKQILLPPFALQAMARGNQREKSREANLKKQAALGNNMSGTEMQRAKEQAADIMRQKQAAAEAKKAEASAGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFK9</accession>
    <name>A0A367LFK9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tf2-1-like SH3-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_1179</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFK9"/>
    <dbReference type="OrthoDB" id="4779840at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056924">
        <property type="entry name" value="SH3_Tf2-1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24626">
        <property type="entry name" value="SH3_Tf2-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tf2-1-like SH3-like" evidence="2">
        <location>
            <begin position="2"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI13201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="247" mass="27792" checksum="E561E9F22FC52043" modified="2018-11-07" version="1">MLLKTKRNIVADGRVAKLAKRQTGPFRVIKRVGHLAYRLDLDKSLNIHPVVSIIQLRPAEAPAKRLGPEPDTDNYKVDRILNIRKIKRGKGLARTEYLLVDDADGERLLDDYDSDSEDSKLLSDNDNMPTNPSSRRQTRRNFYGAYALLEVAKDYIKGLVLGEITQDLAELDKIKKVLDILSYWDCLSKMEKMALEAMEKETTTSNALPLFGRALARRSATSAPTPTLVLSTPERRRPAITPATPLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFM1</accession>
    <name>A0A367LFM1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Succinate-semialdehyde dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="3">1.2.1.24</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">NAD(+)-dependent succinic semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_0289</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; 4-aminobutanoate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.24" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFM1"/>
    <dbReference type="STRING" id="1330021.A0A367LFM1"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004777">
        <property type="term" value="F:succinate-semialdehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009450">
        <property type="term" value="P:gamma-aminobutyric acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07103">
        <property type="entry name" value="ALDH_F5_SSADH_GabD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000004">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000063">
        <property type="entry name" value="Succinate-semialdehyde dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050740">
        <property type="entry name" value="Aldehyde_DH_Superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43353:SF5">
        <property type="entry name" value="SUCCINATE-SEMIALDEHYDE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="10">
        <location>
            <begin position="62"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="10">
        <location>
            <begin position="230"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="187"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI13215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="514" mass="55553" checksum="53708FE4863A8882" modified="2018-11-07" version="1">MALLFLHKASLRCSSRASLLVLARSASTMTAPKLNDPSLLKHDVCYVNGQWVPATSGKTFKVNDLVDPSTGKLIATCPECDAEDTRSAIRAAASSFADFRTTTARERARLLRRWYELVVANADDMAKLITWENGKPLADAKGEVAYAASFFEWFSEEAPRAYGDVIPATVPGNRVLSLKEPVGLELPRRHDHAQDRSRSRGRLHRRLQGARRDAHDGTGLGRARPSRWHPEGVVNVVTTLDNTAAVGEVLTTDPAVNKVSFTGSTGVGKLLMKQSSSTLKRLSMELGGNAPLIVFDDSDIDLAVTGAVASKFRSSGQTCVCANRIYVQAGIYDDFVDRFTRKVSSFKVGNGFEDGSTHGPLIHDRAVTKVMDHIDDARRKGGKVVAGGDRIPDLGANFVQLTVIRDATVEMAVASEETFGPLAALFPFKTEAEVVAMANRAPVGLAGYFFSRDLQRVWRVGMVGVNTGIISDVAAPFGGIKESGFGREGSKYGIAEYQNIKTITFGGMGKPLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFQ8</accession>
    <name>A0A367LFQ8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFQ8"/>
    <dbReference type="STRING" id="1330021.A0A367LFQ8"/>
    <dbReference type="OrthoDB" id="5407799at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd19817">
        <property type="entry name" value="Bbox1_ANCHR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044553">
        <property type="entry name" value="Bbox1_ANCHR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46603">
        <property type="entry name" value="ABSCISSION/NOCUT CHECKPOINT REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46603:SF1">
        <property type="entry name" value="ABSCISSION_NOCUT CHECKPOINT REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22586">
        <property type="entry name" value="ANCHR-like_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="332" mass="35942" checksum="C8F512E3C2E40928" modified="2018-11-07" version="1">MADDIDRSLLDRLQALRGTAATTTAREQRLAVDRAETPSREDALAARLKQLRLRDAARQDSSSVVRKTSIETGNSNGDGDDDEAEDALLRTDDDILEHLVGYEDDDGDDVDDEQVQALLRELSVEPPPTQSQDDDQQGPGQQPTSPPRLVKTTPPPQPKPNALHIPLEPSLPSLPPSLPPLPSGPRASSTDDMASRLAALRDSSSPSSATPPWTLPSVPSAQPSSAAGKGRLSSRYGYTDDDVDSWCTPSSAAGKGRLSSRYGYTDDDVDSWCTVCLEDATLRCLGCDHDPYCARCWREMHRGSYAAFDDRSHRAVQFTGRSEENKVAIGAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFV3</accession>
    <name>A0A367LFV3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5-demethoxyubiquinone hydroxylase, mitochondrial</fullName>
            <shortName evidence="8">DMQ hydroxylase</shortName>
            <ecNumber evidence="8">1.14.99.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Ubiquinone biosynthesis monooxygenase COQ7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">COQ7</name>
        <name evidence="9" type="ORF">L249_1033</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + AH2 + O2 = a 3-demethylubiquinol + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:50908"/>
            <dbReference type="Rhea" id="RHEA-COMP:10859"/>
            <dbReference type="Rhea" id="RHEA-COMP:10914"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:84167"/>
            <dbReference type="ChEBI" id="CHEBI:84422"/>
            <dbReference type="EC" id="1.14.99.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="8">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion inner membrane</location>
            <topology evidence="8">Peripheral membrane protein</topology>
            <orientation evidence="8">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the COQ7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.60" evidence="8"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFV3"/>
    <dbReference type="STRING" id="1330021.A0A367LFV3"/>
    <dbReference type="OrthoDB" id="275371at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008682">
        <property type="term" value="F:3-demethoxyubiquinol 3-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01042">
        <property type="entry name" value="DMQH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01658">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011566">
        <property type="entry name" value="Ubq_synth_Coq7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237:SF4">
        <property type="entry name" value="5-DEMETHOXYUBIQUINONE HYDROXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11237">
        <property type="entry name" value="COENZYME Q10 BIOSYNTHESIS PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03232">
        <property type="entry name" value="COQ7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI13306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="189" mass="21258" checksum="44E90305D511E673" modified="2018-11-07" version="1">MASLTARTPFFSLRVNQAGELAATLIYTAQTPPLVRRHPHLRPLMKHMYDQEAAHLKTFNALIHKHRVRPTALTPIWVGLATSLGWTTALMGREAAMACTEAVETVIGEHYTGQIRNLLEMVSQWEKDGYDVGSEIKHLIAIFSRIRDEELEHLDHAVEHDAKKAEPYWLLTSVIGAGCRAAIWASERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LG46</accession>
    <name>A0A367LG46_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_1222</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LG46"/>
    <dbReference type="STRING" id="1330021.A0A367LG46"/>
    <dbReference type="OrthoDB" id="2158884at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07830">
        <property type="entry name" value="STKc_MAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000233">
        <property type="entry name" value="Meiosis induction protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000314">
        <property type="entry name" value="Serine threonine-protein kinase mak"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="23"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="362"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="480"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="623"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="742"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="417"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="501"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI13390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="790" mass="86605" checksum="C8D5768D8B9619FD" modified="2018-11-07" version="1">MTVVGDLNPRGQPHGQLALEDRFEVIKEIGDGSFGSVVLARVRTAGANVARRGSVVAIKSMKKTFDSLAPCLELREVVFLRTLPQHPHLVPAIDIFLDPYSKKLHICMEYMEGNLYQLMKARDHKCLDNASVKSILFQIMQGLEHIHSHHFFHRDIKPENILVSTSSHQESSTSFRRYSALVTPPSTPPTYTVKLADFGLARETHSKLPYTTYVSTRWYRAPEVLMRAGEYSSPVDIWAVGAMAVEVATLKPLFPGGNEVDQVWRVCEVMGSPGNWYNKAGVRIGGGDWKEGNKLAGKLGFSFPKMVPHPMETILQPPQWPPALSSFVTWCLMWDPKNRPTSSQALMHDYFHDAVDPLRPRSAASRALGRKQSDLAGRGSREAAQGQSKPSWFRKSLIGRSESSERVEDHAHHRPLPAAAAAATTAAPAPDVASGRLRPAGGKRSTWTNGLSNVAPMPILPTIRPISPLSDAVTARANDGQADVGANGRGQEKSNNKKMSRQLSVASSTNHYAESAGGNYAELHRQQAERALNGNTGLASPPSGHKESFFSHLRKRARRFSGRHQTPVSPSYDEMEAQIGCGPWSSNRSSVVVEQQPTPAAKPEAYESLDRALRDVQTNVDLRSPVPASHQYTPSSSKLKRHHSLPHQQPRSVDNLIGAARGGPISSRTRRAQAAQGVQQYEAPAEEDEFLDELVPPTHQRTTTKVSGAKALRQSASNLGLTTPQPYPSPSPSANGHQVVYEDGQEVVTPRPLDLGKKSDSQYKWPTPPYEGSEWAASASASIWAASNRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGB8</accession>
    <name>A0A367LGB8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Autophagy-related protein 28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_5543</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGB8"/>
    <dbReference type="STRING" id="1330021.A0A367LGB8"/>
    <dbReference type="OrthoDB" id="5342758at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="68"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="228"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="594"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="327"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="162"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="608"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="642"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI13484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="654" mass="72371" checksum="88198F96DC68EDD8" modified="2018-11-07" version="1">MIDARDQRIACFVSCFTDLARSQLVSFLFSKLSSSFAMGPLSPPSVARRFSHDADMSSRSLLHQNSYEIPLNPLGPRPDSAPQSAEDDFPQPRLRRPAVPNLGSVDQSRKSKDRLLFSESLSRQRQPALFAGPPPPISSSVIMSHASSPSSQNSKHGLGSHGITSQVSPISSDTVPGQSREPCPSQTSDSAWRGLWRRQRSLEEQVQQLLDLQASALMSAGAYGLEGSSGGNRDGYSEEGSITPTGTLDSASPARPRMQRSLYVPPMSTPEGNVIPVRQPARSRLTGLRRARHGIGHSLADLARVKQEEDLYVNAALSERKKVCTQLNRLTTRRTGIRNELTTLENDEDEPLGKELRELGTEHSVLNEDIQRLEKQLVGMRNRRRWLKDKMEDVRSKREAGLSGYHGALKNVDAEVNALLRRPPVLPLDQSLLSDGGQNVESDLSAGLEFLRLRPERRTVEMAQTWWEAEVGILERRMARINEEQEALEQGGATWQEAVALVTDYERGLRQLTKPSCGSPAAEETGLAQENTIRNQLPRMDQVMVKLAELMRRAESKHWNLLICAIGAELEAFKEAYAILKAIVDDDDVFSDDGVNPAYRSPPSAAKNIEEPRKSSPGDKGGRGQSEESDNEVPLDLLVSRADVERESIEDEVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHB7</accession>
    <name>A0A367LHB7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_8249</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHB7"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI13833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="114" mass="12673" checksum="C7636AF5481FD7D8" modified="2018-11-07" version="1">MHVINQPAFAPSWTNVVCLSLETNLFLAALFIRNSLSARSATEHAISTALRPLSWDVQDWQESGSRNPNQSRDNLSSHLATLGTYQATYRTKDTSITPSLNPVTVEGYRINILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHH3</accession>
    <name>A0A367LHH3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHH3"/>
    <dbReference type="OrthoDB" id="2532734at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="62" mass="6665" checksum="11ECB5F1D756A0F9" modified="2018-11-07" version="1">MDSSKQQNKKGEDVTTQPINPDGGSKTVNAFNAQPGPVIPDKMPAQEGTAEDRQARVKTLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHQ1</accession>
    <name>A0A367LHQ1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_8186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHQ1"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI13940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="53" mass="5984" checksum="FCA7F4615FD7C8A1" modified="2018-11-07" version="1">MGSTGANLLLLFSPLLDKNFPFHLLQFRLGILVGVQIKVVRRTIDAEFRAMLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHT6</accession>
    <name>A0A367LHT6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycoside hydrolase family 5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_7924</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHT6"/>
    <dbReference type="STRING" id="1330021.A0A367LHT6"/>
    <dbReference type="OrthoDB" id="442731at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31263">
        <property type="entry name" value="CELLULASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14560)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31263:SF0">
        <property type="entry name" value="CELLULASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14560)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016917097" description="Glycoside hydrolase family 5 domain-containing protein" evidence="5">
        <location>
            <begin position="23"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="6">
        <location>
            <begin position="77"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI13957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="430" mass="47798" checksum="BFD529D4691CE115" modified="2018-11-07" version="1">MKAAVTAVALLCHVCLLSPGLASVEAPSQTTIAKPRLPLSVSSRWIVDTAGQRVKLRCINWAGHLEVNIPEGLHRQSVEKTVDWIATQGFNCVRLTYSTDMALQPNVRVRESFRRAAKAAGVEEGAMMRLYSSAVERNPFLADGTVINVFDRVQAALWNRGLVTILDNHVSRASWCCNLTDGNGWWKDAPLYMASNSRFFDPDEWRAGLVAMATWSRSRPGVVGLSLRNELRASVTQLVFAPETWLRYMPTAARLVHASNPDALVIVGGINGGTDLSPLRLLRPMDEAGWATKRVWEAHSYSFTVTTPNFGICPLLQAEYGGLYGFVLEQKKPYTGPLFLSEFGVGMTGGNPHHDGLSDMDARFLDCLAQYMAGNDADWALWAVQGSYYVRDKTVDHNETWGALDYQWRDWRNPIFKAKLQKMMGVTQGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LI80</accession>
    <name>A0A367LI80_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytoplasmic tRNA 2-thiolation protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">NCS2</name>
        <name evidence="3" type="synonym">CTU2</name>
        <name evidence="4" type="ORF">L249_7939</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CTU2/NCS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI14087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LI80"/>
    <dbReference type="STRING" id="1330021.A0A367LI80"/>
    <dbReference type="OrthoDB" id="25129at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032447">
        <property type="term" value="P:protein urmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03054">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019407">
        <property type="entry name" value="CTU2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882:SF14">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10288">
        <property type="entry name" value="CTU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI14087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="374" mass="40664" checksum="C6A6E4DA734F2179" modified="2018-11-07" version="1">MTDAAKPCSRCRDPSAPYSLRNAATCRNCFVTYVEGKAGRRLGALARDTKTSGPPAPRKYLAGLSFGPSSTVMTHILDTSARFYSSKKSSPAFEPLVIHVDTDLSRCDSSSIRVASFRERFPSLTFECVHLSKVLDAKTIEWSALTGLEGVAENGRDPVSRLQRLLDSATSKPQLLRLLVRSLLLHIAIERSCSALLLGHSTTALASLTLSHVANGRGHVVPWQVNDGPYTVCTYDPSGVSGPARIAMPVYYPLRQVLRNEVTCYMEMMPSLRHLVPSDGAVSRSVVSHKDSSIEDVIETYFDGVEGPYSGIVANVVQTTGKLERIPADSFCPLCGMALDEQGDSRWAGELGDSSDGQIDLKRLCHGCRRTLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIM8</accession>
    <name>A0A367LIM8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_6155</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIM8"/>
    <dbReference type="STRING" id="1330021.A0A367LIM8"/>
    <dbReference type="OrthoDB" id="10251741at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002677">
        <property type="entry name" value="Ribosomal_bL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051510">
        <property type="entry name" value="SKI8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01031">
        <property type="entry name" value="rpmF_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44090:SF1">
        <property type="entry name" value="SUPERKILLER COMPLEX PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44090">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01783">
        <property type="entry name" value="Ribosomal_L32p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="348"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI14269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="430" mass="45835" checksum="C0857E6EFACE8B11" modified="2018-11-07" version="1">MATAAAAAVMAPLASRLVFAPIISLPLLRWPVIVSPRPLLAGINLRLPTLDDIWESILRAVPKKKTSHSRKRHRQMAGKALKDVTGLCECPGCGETKRTHRICQRCLEDMRKIWREDAPDFKPFETPSKQYLTAHTVDEAHITDVFSLATTPKAVLSASGSSTLHVHDTTNSSFALKQSIPDAHKLGCHHICASADGKVAASAGFGGELTIWKVDADTGEWHADGDVIAQGGGGGGGGGEAWALALSYDGSRLAATTHDGRVNVWNVADKARPKVFEYETGSPGTGSFGMCVDLSRDGKYTASGHQNGLVKPVRAVAFSPGSSRLAAAGDAGVIALYDMKHGEHVGNLTGHGSWITTLDWSFTGEYLLSGSMDGKVKVWSVERAACVATHSETDKALWAARWLPKTGKSEMFCTAGANRSISFYREATGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJ96</accession>
    <name>A0A367LJ96_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RING-CH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_5923</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJ96"/>
    <dbReference type="STRING" id="1330021.A0A367LJ96"/>
    <dbReference type="OrthoDB" id="5817083at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46283">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="118"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="10">
        <location>
            <begin position="30"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="356"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="491"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="363"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI14495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="510" mass="56592" checksum="7D090863522FD396" modified="2018-11-07" version="1">MADRRKTAEDDADDDDDDDDALPPLVQQPRSAHAPRRCFICLTDESPDDPPEEWVEPCPCTLEAHQDCMLSWVTNCERSNKPLLCPICKSTIQLEASWDPIVAATGAIYRRFTTVSPLLLFTGVSMGLQFSLQLYGGLALWAFAGKDSLLRFLLGPDMYLDATAGSHRGFVTDRIWKALAMMNVAPVLLLVRFFPVLGYRFFCPTASMFGMYQVMQDDEFLTWPPSPKLAMTVFPYVHATYHYLWTKFAMPYETNLNRQLMGTPTVEVTGRQEAADRVQGVRNVNEGLRGLLQAVVDALEPEDEGHEMNRLDELLRENDGDQGRLQGDIVVRVQIGEAEADQAPIEAVQLEAQADGGLGNLGDDGNNNNNNNGVEDNDDAGQERRGHEVPAAPPRAMSIGMMLTSVTNIVVGALILPGVSMVMGELLRLALPRTWTLARSRNPWGRFGVAERGGLLQQQWGRSLIGGCLFVVLRDAARVYTKSRGAAAMETRRVRNVDRQRRERNNGTAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJF3</accession>
    <name>A0A367LJF3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Polynucleotide kinase 3'-phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7013</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJF3"/>
    <dbReference type="STRING" id="1330021.A0A367LJF3"/>
    <dbReference type="OrthoDB" id="19045at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046404">
        <property type="term" value="F:ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046403">
        <property type="term" value="F:polynucleotide 3'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000078">
        <property type="entry name" value="Bifunctional polynucleotide phosphatase/kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002548">
        <property type="entry name" value="DNA kinase/phosphatase Pnk1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013954">
        <property type="entry name" value="PNK3P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006551">
        <property type="entry name" value="Polynucleotide_phosphatase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01664">
        <property type="entry name" value="DNA-3'-Pase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083:SF9">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08645">
        <property type="entry name" value="PNK3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="474" mass="52704" checksum="79BCA5A80C322219" modified="2018-11-07" version="1">MPSSPVASLPLILPRLARRLAMESSASSGKRRASNPTSSLSTTKRTVQSSTTKSAVDSFFTPMSQKPKDRIEWSERAGDAGGPSTLLVGRRHTAVSETDGRRSKKIAAFDLDSTLIATLSGKKHPTSATDWRWWHPSVPQRLRQLYHEQGYRVVILSNQAGLTLHPAPKSKAPKPGTLRRVADFKLKCSTILNGLDLPTAIYIATERDAFRKPRTAMWTHVCRDCDLSETEVDLDGSFFVGDAGGRLAGPDGGKDFSCSDRNFAHNVGIAYKTPEEFFLGLAPRGFCRDLDLARYPFNSSSSSSSGIEFLKTNERDVILFCGPPGAGKSTFYRNHLQPLGYERINQDTLKSREKCIRTGRELLSDGCSVVIDNTNADPETRAIWVGLAKKSGIPIRCVWFKTPMQVCEHNDAVRALNPLFNPEARTGLPKLAFNGFSTRFKEPKLAEGFQDVMEVEFEFRGTQEDYDVWGRYWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJH8</accession>
    <name>A0A367LJH8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6581</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJH8"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="183" mass="18147" checksum="E4E283DC2702CF53" modified="2018-11-07" version="1" fragment="single">MPPALSEQGGSGSSSRSDSSRSSSRSNARPGGEGGRASPLPAIGGEEGGKRAKLAQKAAAAAALIAATAGTDDFARNEAEDANADGNNKHCADAGADDDKRLADAAANSDDNYYADTAAKVDNYADGAADADRAEAVAAAATAAADAAAAREAKKAVFTAATRAKRREEARRAAEKAVAPALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJW6</accession>
    <name>A0A367LJW6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dolichol phosphate-mannose biosynthesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_6450</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DPM2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJW6"/>
    <dbReference type="STRING" id="1330021.A0A367LJW6"/>
    <dbReference type="OrthoDB" id="311279at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033185">
        <property type="term" value="C:dolichol-phosphate-mannose synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180047">
        <property type="term" value="P:dolichol phosphate mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009914">
        <property type="entry name" value="DPM2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15039">
        <property type="entry name" value="DOLICHOL PHOSPHATE-MANNOSE BIOSYNTHESIS REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15039:SF11">
        <property type="entry name" value="DOLICHOL PHOSPHATE-MANNOSE BIOSYNTHESIS REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07297">
        <property type="entry name" value="DPM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI14714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="88" mass="9715" checksum="E63DF501E4B6A78E" modified="2018-11-07" version="1" fragment="single">LDKLLGLAMLVAASVVFIYYSVWTLLMPFVDDDHPLQNFFLPRVWAIRIPVILVLLASAVVGSFLGTVMIRSNRKKASKAKAAAKKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKC9</accession>
    <name>A0A367LKC9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_6999</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKC9"/>
    <dbReference type="STRING" id="1330021.A0A367LKC9"/>
    <dbReference type="OrthoDB" id="1594986at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031106">
        <property type="term" value="P:septin ring organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05992">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13246">
        <property type="entry name" value="PH_Scd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000176">
        <property type="entry name" value="Rho guanyl nucleotide exchange factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010481">
        <property type="entry name" value="Cdc24/Scd1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033511">
        <property type="entry name" value="Cdc24/Scd1_PH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053026">
        <property type="entry name" value="CDC42_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001331">
        <property type="entry name" value="GDS_CDC24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47339">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47339:SF1">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06395">
        <property type="entry name" value="CDC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15411">
        <property type="entry name" value="PH_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00741">
        <property type="entry name" value="DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="429"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="3">
        <location>
            <begin position="1098"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="780"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="797"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="818"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="855"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="953"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1037"/>
            <end position="1063"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI14895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1198" mass="131232" checksum="F21A60A26E4737CB" modified="2018-11-07" version="1">MSRPPLSGGRQPLEPQEARRSHLRLPPKYPLPCEWRVLARRCDKDRPGSLPRPSARVRAPSTPPPSCPSSLIRCLLTQPAFLRDHLSALPTCPPKQPRLPDRRTSRFDCQPRRLTDANHDRVGQAAESHIESYHRHPSPSSRRASHRSGGAFRLLPRYDGDTLPLSANNEPHKRYSDRSTSSRNKRLDIDMAHAPLLRNNTLPAFESSLSSTGGLQQNSMSNAPRASQLSGTTAYAGSSSSSLNSLTSGGTVVPGQNGGPVVATTNIINQKADACPASNPSSSNSIRTIPSTRSGICSAPGYPLLAIYNALQPSEPLKVDDATASEAKKSKIAIFKFVQACMKELRVPPSESFVITDLMGNDTSGFVKVGSANPTVRRLLSSLTRPMKQVTQVVNYVLDLAESRGLLLQSVPSPEDEAVIVATGSQMSYRDHIVKELVDTERKYVQDLENLHDLKKALEQKGAVPGDIVHQIFLNINAILDFQRRFLIRVETTNSMPKSVQRWGAPFCFYEDAFDIYQPFIANQRKAAQIANQVFDKIQLSDHPVAADFNTLDGFLLKPMQRLVKYPLLLKDLHKKTEDPEIKEDLMMGCEAAERVLHKANEAVNQDLLDEALEGLISRVDDWKTHRVESFGKLLLHGIFPVITGKSDQEKDYEVYLFECILLCCKEASATRSKDKKDKTRSSGPKVRSRNSKLQLKGRIFMTNVTDILTISKPGHHTVQIWWKGDPGIENFTIKFLSEENMKKWATGLHTQRNEMLPRLSSSGADGLAADFSWTRDHAGGLENPYLNQEEDDDENGPQTAPAQFPMSTQAMPRRPSKTNLRQRSATGDSSQSLAGVARAPPSRFQLPVPYGPLSLQTQGNGALSPSGRAGDSYFSPVAESPASSRTSAASGMFPGPPYLSKAGAPPPGWDDSNRYTAPAVPRAPSRDSSSPNPHTMPHRNPRGPSLPAMATQSQSAAQQQRSRSYSTPDANASMPRQRHPSQSNVPAVPGIPQHLHPAHDASIPRSQTGSPRGDVPARTSTQSSGSQRERSHKHSSSLGGTMAQFPTQPTHARPNAPTSSGGYSLRVDSMSANSRTVSPALGTGSATPQSANEMPLPTQLKVRVNCDSGNYVTLVVAFNITYQSLTDRIDAKLARFMNSSIGRGMLKLRYRDEDGDLVSIESDDDIQIAFMEWREGMRNMYSGGVGEIELFCVGEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKJ8</accession>
    <name>A0A367LKJ8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetylglucosamine-induced protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_6848</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKJ8"/>
    <dbReference type="STRING" id="1330021.A0A367LKJ8"/>
    <dbReference type="OrthoDB" id="10053431at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022036">
        <property type="entry name" value="DUF3605"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35020">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-INDUCED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35020:SF4">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-INDUCED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12239">
        <property type="entry name" value="DUF3605"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="228" mass="26676" checksum="F32D50789DB0F2DA" modified="2018-11-07" version="1">MGSLPYWHYNVPDDEKTAECPPFLLHLTDKDRRIIGSPESAFSLLDWPRVRQLVTSNRLDLFQRSPLSLRRYRAFVYALSESHGSVTEYLLRHRLRWPDPPVAPRGRPFEFPLDDVKILLNDWPYGIDARIVHLVVWTKFPLEEDPTTGQLTDSARADVDGFVSNTFRSHLPADRVIWFKNWSALRSIDQIQHFHVMMFDPDPDFIRHITDNDVPQYLMPQSSHLAQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKK4</accession>
    <name>A0A367LKK4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Methionine aminopeptidase</fullName>
            <ecNumber evidence="11">3.4.11.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_7075</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="11">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with zinc, cobalt, manganese or divalent iron ions. Has high activity with zinc; zinc cofactor is transferred into the active site region by the ZNG1 zinc chaperone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Associates with the 60S ribosomal subunit of the 80S translational complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="11"/>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKK4"/>
    <dbReference type="STRING" id="1330021.A0A367LKK4"/>
    <dbReference type="OrthoDB" id="3209743at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000010">
        <property type="entry name" value="Methionine aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031615">
        <property type="entry name" value="Zfn-C6H2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330:SF7">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15801">
        <property type="entry name" value="zf-C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52013">
        <property type="entry name" value="ZF_C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9 11" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C6H2-type" evidence="12">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>N-terminal L-methionine residue</name>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>N-terminal L-methionine residue</name>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI14975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="373" mass="41423" checksum="98B96C705A6FDE9B" modified="2018-11-07" version="1">MPELPAKRKCTGVNCENDAGSLHCPTCLKLEIKDSYFCSQDCFKKSWVRGTTGNYNPFPSFPFSGPLRPVYPLSESRVVPKSIPHPVWSEDGNPRYSRSPANRNKIDILDAKGQDGMRKSCRLAREVLDIAAAAAQPGVTTDAVDEVVHRACIERNSYPSPLNYNHFPKSCCTSVNEVICHGIPDKRVLVDGDILNIDISLFHDGYHADLNETYYIGEKAKMDVENVRVVETARQCLEEAIKAVKPGVAIREFGNIIEKHAKSQNCSVIRTYCGHGVNTLFHCAPNVPHYAKNKAVGECKPGMTFTIEPMIALGKYRDMTWPDNWTSTTIDGKRTAQFEHTLLVTNNGVEILTARNPGSPGGQITVQTDDRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLE2</accession>
    <name>A0A367LLE2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6696</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLE2"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="277" mass="31575" checksum="03C167DBE13EE0D6" modified="2018-11-07" version="1">MDKSYIHMPVPAGQPPGLFTNLPSAGGYSQGQNNNQQSQEMEAATLRHHQRERHMRSFVEISSKINHQRCHGKSQHEKGQMLQPRKHCLVHLGRRPNLTIAMRDAVKALPVSRLGTRSRLHLADTTAEMSNVLTPGAGRAVVFLSDYMIPSFIKVHDVNLHWPDSSFENTGGDQLWQPRFPMVTTMAMPSRPRASFHIYSYRLQHRALNIDPSKPITMKHVRSFLSPVLRPVTRCHVGFDGKRCEAEYHRQLQQVDEFTLRCKFADMKTHQEPSAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLK3</accession>
    <name>A0A367LLK3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLK3"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="282" mass="31027" checksum="B1D6F1DAC07658D5" modified="2018-11-07" version="1">MATDLYLCTDTGIFRSHYREGALLTSRLKGLFIVRAFHADKASPARLHFPITGRVKIAFAPCQTTIMPCGLRSFHASSCMKAVARHGCCYRLIRRGINKTKLKGRIGGGGMGIRAGKRGHCKEMVPTSSDKILGVVLSRISRSMRSMTKLDQDFDLWIWISIWQPALADKGQDFPQDNSKPTHTKPASFGTRLPIVKFASCSARHHWTGFGVADTSLRGGSHGKEKESAPPPTAATDNNLTCSSRRRTMPDRCLNRGSITTNQQTTDDNSPPLPLLTPFEGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLY7</accession>
    <name>A0A367LLY7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromatin modification-related protein EAF6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Dipeptidyl-peptidase V</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L249_3420</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EAF6 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S9C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLY7"/>
    <dbReference type="STRING" id="1330021.A0A367LLY7"/>
    <dbReference type="OrthoDB" id="416344at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00076">
        <property type="entry name" value="HFD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000028">
        <property type="entry name" value="S9 family peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006565">
        <property type="entry name" value="BTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015418">
        <property type="entry name" value="Eaf6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="WD40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776:SF13">
        <property type="entry name" value="DIPEPTIDYL-PEPTIDASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776">
        <property type="entry name" value="SERINE PEPTIDASE S9 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07524">
        <property type="entry name" value="Bromo_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09340">
        <property type="entry name" value="NuA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00576">
        <property type="entry name" value="BTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromodomain associated" evidence="16">
        <location>
            <begin position="866"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="75"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1026"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="83"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1057"/>
            <end position="1068"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCI15444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1068" mass="117632" checksum="71623A3B29A026EC" modified="2018-11-07" version="1">MGDNKQNNAPAATAEFKKAQSRVRELVERRRAQERRLAQLEDGIALKESTYLESTPAGNIITGFENYMKGASGAAAQRRKTGSADQNRVFSRSSISYRPNNADFSTPGESTPASHTPTPLSASFRDSASAHQTPMPNKTSSKAKRKDGDEGEAQALASKKRTSFGAVLLSAPRRSAGIPNWSGDLVLYSVMSYSFETHSRSSSIRVFNIKQGLSYRIVDHPDASDAVWIGDEDVLYFKPGDHGYTMMYTRHVGEDSEPQLIHKIKGNIFAPKTKKLPDGKTAICLAAVTTPAGYMLYPPGEVKPHSSAKVYSSLFVRHWDAWTTRNSNSLWYGQLSNKNGKWQLDGPGFTNLLAGTRLVSPVPNFGGAGDFDIAENAICFVAKDPTLNQARYTKTDLYYVPIKSFREKPTGPPQMVKTGELRGYSTSPTFSGDGKKIAFARMKNQQYESDKSRLLVIPDVGDLSKVQELHETSCGRGGWDYSADSISWSHDDKELFVTAEMHGSVLLWRLPSSPAKDKMPTVAFHHQGSVTNFRPLGKGPLLFISTRSLVDSSNYATLDYSTGAVCQVSSISRNGRTFGLSRRQVGEFWYPGSAGYENHALVVKPSKFDESKKYPLALLIHGGPQGAWTDDWSTRWNPAVFAEQGYVVVCPNPTGSTGYGQKHVDAITRNWGGNPYEDLVKCFEFLEKEVSYIDTEHAVALGASYGGYMINWIQGHELGRKFKALVCHDGVFSTQNQWATEELFFPEHDFGGTLWEKRDNYVKWDPSMHLDQWATPQLLIHNELDYRIPISEGLAMFNVLQARGVPSKLIVFPDENHWVTNPENSLVWHREVLAWINKYSGIADAGGWEGVVAVVQDRAATMSGQAAVFHALLRPSMLQILRATGYHATKGAVLDSVTDLAARYLYALCEATAGHASHNHGTPGDYTVADVGLALGDVGALLPERRGAGWDRGDGLVEDARGLDEFLAWFSGPRMRELMDMARDGESDATDYLAALKKKHNKTGDDNKYHGTLIGRLADATCDIQVEGGPEPSIDEWSPAPSTDNGSVTEGRLPDVGVEDEDDKMDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LM26</accession>
    <name>A0A367LM26_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_3401</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LM26"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI15437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="102" mass="11336" checksum="18DA5B30C16D7B92" modified="2018-11-07" version="1">MAGYMTGKDSLSAWVGMEGVAFNFAIEPAGWRTIVNRRQFVFKVPPRKMTMICHLPASLVSSKKKRITTATVSMNCLGLYRSGDIGHCQLVSFGNCKYPLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LME3</accession>
    <name>A0A367LME3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LME3"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="67" mass="6942" checksum="D2CB3515C96D7154" modified="2018-11-07" version="1">MSGKKGGGRGSSLQRSSGTKGGKEGGGETVCQVKTARTKGKEEEEEEEEEEETAAWALSPLSLSPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMI7</accession>
    <name>A0A367LMI7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_3430</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CENP-K/MCM22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMI7"/>
    <dbReference type="OrthoDB" id="9445768at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020993">
        <property type="entry name" value="Centromere_CenpK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14401">
        <property type="entry name" value="CENTROMERE PROTEIN K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14401:SF6">
        <property type="entry name" value="CENTROMERE PROTEIN K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI15611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="329" mass="36124" checksum="3E3E334B460F3C70" modified="2018-11-07" version="1">MDANPPHQSETQIHASNLDHTLKELQRRVQEHEAELQRLRGGPGPAPASLSPNAQSAVIKAALEEVTKSEPFLPSPNSVLPALVALRKTHRVIIESEAELAAQKPRLDRAKSRLESAQAALTDQKLLGDALTVRIQSLRSRLESFADHDQDHEEPSHGALRRMDTLRAVKDKYDANTASLMRSLLAFIDNHLAAMLAAEELGGPVVGSATEAHLDHLDAGFNAQGKPNKIKDKAQNQDRRQRRIDDIWGAGRDGAVDDEVAAAAAEMQRLTEELLNTLVEARGDSSASYVRLARESAAARFLVRSQVAQFHPKDATRLRLVDFGRELES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMS8</accession>
    <name>A0A367LMS8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L249_3444</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BCC 54312</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the neutral sphingomyelinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMS8"/>
    <dbReference type="STRING" id="1330021.A0A367LMS8"/>
    <dbReference type="OrthoDB" id="387657at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038772">
        <property type="entry name" value="Sph/SMPD2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320:SF24">
        <property type="entry name" value="PHOSPHODIESTERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320">
        <property type="entry name" value="SPHINGOMYELINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="432"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="15">
        <location>
            <begin position="27"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="335"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="335"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="349"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCI15719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="489" mass="54207" checksum="8D5B6D566C21D83B" modified="2018-11-07" version="1">MPSKDKADVSISTSTSTTTLPTELTILTLNCWGLLHISSDRKQRLEEIGRQIGSAAEAHIVCLQECWVEADFEAIRQSTRQLLPHARLFRSGVLGSGLAILSRWPLEDSSMVRFPLNGRPTAFWRGDWYVGKGVACAVLRLGPRHLIHVLNTHKTHAPYATTNHSHHSSYACHRIAQAWHMSKLLRTATSTGNLVLAVGDFNMLPLSLPHRIITSRAPVNDAWRVLHPNSSLGPSAAQPPGALFNLEENGVTSDSIYNTWRWTKNARNSLRAGRPAAPIDPNAPDPRGKRLDYVFVSDTKPWAVADAAVVLTEPHPELGVSLSDHFAVRVTLRQQHQQQHYSTRSSADDKDDHEDADDDDDDNNNNNNDKVENDLLHLSKADCDEILSLIDTYTARERVQRRCRALHFCAALVVWAACLVAAWFSPRDLVCFLIVLVASLVLAAGIVDGILALFFFTSELQSLDEFAWEVRNARSVVASPPKQASNADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMT8</accession>
    <name>A0A367LMT8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_2223</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMT8"/>
    <dbReference type="STRING" id="1330021.A0A367LMT8"/>
    <dbReference type="OrthoDB" id="409947at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001409">
        <property type="term" value="F:guanine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053042">
        <property type="entry name" value="Mito_GTP/GDP_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46974">
        <property type="entry name" value="MITOCHONDRIAL GTP/GDP CARRIER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46974:SF1">
        <property type="entry name" value="MITOCHONDRIAL GTP_GDP CARRIER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="6">
        <location>
            <begin position="253"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI15729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="37647" checksum="1ABE4A1475F22077" modified="2018-11-07" version="1">MSSPAMAPAMVTGREKESNLARLLGSGSAGIAELAVFHPEEEAFSWLRAEILTHVQVDTIAKRLMSNQTRITNTSQLNQVIFKNQVGATAGRKFVSLFPGLGYAAGYKVLQRIYKYGGQPIARDYLAKHYGRDFEATFGKKTGKAMMHSTAGSLIGIGEIVLLPLDVLKIKRQTNPEAFRGRGIVKIVADEGFGLYRGWGWTAARNAPGSFAVLHPFQLDCLPHQDTETLFGGSAFAKEYLFHLQDYNKATWAQNFVASIAGASASLVVSAPLDVIKTRIQNRNFENPESGFRILTNMARQEGMTSFFKGLVPKLLMTGPKLVFSFWLAQTLIPAFDQALHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMX4</accession>
    <name>A0A367LMX4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Exoribonuclease phosphorolytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_3415</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMX4"/>
    <dbReference type="STRING" id="1330021.A0A367LMX4"/>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11372">
        <property type="entry name" value="RNase_PH_RRP46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000005">
        <property type="entry name" value="NAD+ kinase Utr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10330:FF:000025">
        <property type="entry name" value="NAD+ kinase Utr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF0">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="7">
        <location>
            <begin position="11"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI15592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="776" mass="83952" checksum="51B9672FAD8C9C95" modified="2018-11-07" version="1">MNHPSAVLSPLPRADGSSTFSASGFSVMAVVNGPVEAPRRDENAFEAIVEVMVRPAAGPGGTAERLLEVMLQSALRQLIPVRTFPRTMIQITLQILEVPQSPYKNTRILHPQVNLALVPALLHASILGLISAAVPLKAIATAVSLAVRADGDTLVDPGPDDMDKASSIHALAFTSDDELLLAESAGSFSVDAWHAILETGQSVCCREPGPDAAMSAGVPESQGIRTFIRSVTEARSDEDLHWKNAMALAEPGTLDPALADNDKGIIVSPLKAAPPPAPAPQGCRPSSVVSRQNKPEALPLDMHLSPGSDPRAASPIRLADALHGLAKKQQSTPRTALQSPCFYHERFGEAVKIERVLEEMESDDVMSHSRLVQTATCVREVSRQLRRRPVRGAVRSVMIVTKARDNHLVHLTRDLAGWLLRTPRYGSPVGVEVYVDAKLRNSKRFDAAGLVAEDPRFGAMLRYWTPDLCWVEPERFDLVLTLGGDGTVLFTSWLFQRVVPPVLSFSLGSLGFMTQFEFERYKDHLDRVMGDGGMKINLRMRFTCTVKRGGGGGGGGDGDGDDDDGRESEQFQVLNELVIDRGPSPYVSNLELYGDGEPLTVVQADGCIFSTPTGSTAYSLSAGGSLVHPDIPAILLTPICPHTLSFRPMVLSDTMALRVVVPRGSRATAYCSFDGKGRVELRQGDCVTISASQFPFPTVTRTDTEWFDSVSRTLRWNVRAATQRPFDPADDAAAASNGSEADSDCWDIDQDSAYFPSEEGSVSASPIRRQMSMLCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LN93</accession>
    <name>A0A367LN93_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_2830</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LN93"/>
    <dbReference type="STRING" id="1330021.A0A367LN93"/>
    <dbReference type="OrthoDB" id="18453at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000832">
        <property type="entry name" value="GPCR_2_secretin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF0">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 116"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00002">
        <property type="entry name" value="7tm_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="7">
        <location>
            <begin position="24"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="430"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI15915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="457" mass="50872" checksum="34B72BDDDF3603B6" modified="2018-11-07" version="1" fragment="single">TELASGMLRHPSTQGLSPQEIESLITIERTGAGLSMVAIGLIALTFIVFKKLRTTPNLFLLFASLANAGASVASMVGYDGLHKGENSSLCQAQAFIFEWFMQSDPWWSFAMAVNVYLVFFHNADPASFRRYIWVYCLVCFGGPLIPAIVLICITDKDRGPVYGDATLWCWISDNWSLVRLYAYYIPIWLCISLSFVIYFVVGYQVFHRRNQLISMSMHEKGLQKPNNKFVRSGFDSAEEARSTSVTSMLAIMRSNTIWQSLTRRQDVYGTVVTEVHITSSLPPLDFEMPKSPPNLHARGGLPNSSSWASGLHGESSAVRNHNHHFETICSSDSPRAKRGNCFGMIKAAVTEASLRLKRLDPVKMAYLRTSFIFGFAVLITWIPSSVNRLYSLANGGRISFGLSVASGLDMLAPRHRDMFERSPSAGVGDGKAKRSNVDGLEPPRRTLARSEVRYLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNI4</accession>
    <name>A0A367LNI4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glycosyltransferase family 15 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_2504</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNI4"/>
    <dbReference type="STRING" id="1330021.A0A367LNI4"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF2">
        <property type="entry name" value="MANNOSYLTRANSFERASE KTR5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018153">
        <property type="entry name" value="Glyco_trans_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR018153-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI16006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="506" mass="58646" checksum="368222AB75D550E3" modified="2018-11-07" version="1">MMDLFRRASRMVPSPRLLQLPEHDEKRGPSRRKGFASRLAFFRRPLRLRGNSSVSVPLGVVIIFPLLVVVLILVLFVRHPSSPSRIMMPAGAPPSIRKISEKHDKVFVTGCLEPDTSKPRANAAFVVLARNKELDGVIQSIKSVERHFNQWYHYPYVFLNDGEFDDVFKETVRNYTSANVEFGKVGPEMWGYPDWIDPKVAKEGIAKQGDAAVMYGGLESYHAMCRFYSGFFYKHELLLKYDWYWRVEPEITYFCDITYDPFLKMIEHNKTYGFTIAVKELRETVPNIFRYASAYKRVNNITSQGLWEMFVEPPPEPVEEKRKDTSLPEEVLQNEPTKNAPADVDPEAMEGEKYNMCHFWSNFEIARLSWFRSKEYNDFFEMMDRSGGFWMERWGDAPIHSLAAGALLSPGDIHYFRDFGYRHTTIQHCPANAPARQLPRQPYLEMTTLDEKKRLEEDQYWENWDEVKENGVGCRCRCDTDIVDIEGKEGSCLAEWVDVAGGWASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNR9</accession>
    <name>A0A367LNR9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_3062</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNR9"/>
    <dbReference type="STRING" id="1330021.A0A367LNR9"/>
    <dbReference type="OrthoDB" id="206213at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046523">
        <property type="term" value="F:S-methyl-5-thioribose-1-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475">
        <property type="entry name" value="METHYLTHIORIBOSE-1-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43475:SF3">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G14290)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="48"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI16078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="511" mass="55167" checksum="43FD73D440ADD452" modified="2018-11-07" version="1">MVAASASASTPQLEKRAVAGSFIFRFPPRGQRPQVALFQRSARVRTYRVEATDDDALTTAWREIAEETGLGPRSLRLLRQGKPYSFIDRSVGREWTINPFAFALRHDQDAAAIKLDDEHDSFAWFDPADVPEDDGEASSFRGVPHLLDSLRRVWFELEIRPAAAAALLDHGLRRLRHHHAGGGARQLASYALDTFTRVLAALDRNVDSARWWRNLRIVAWHLWKNGREAMGASTLRLLLDALTVVETKLPRDSSARLPQDFAEDVVEALHVIAGRRAEPSTALQDAFVFWLSQQQASNPETASPIRVVTLSSSATVASCLGHGLAQGSALDVNVLESRPLFEGASMARAIAASIRAAGDPPGASVAVHTDASVALAARGAHIIVLGADIIDACGNVSNKTGSLPAILAARHVAPAVKVVVVAESGKVLPLPVDPPATSETHDPAQVWQAWADDDRDAAQAGDIGLSNVYLENVPADLIDCYITEAGVTTRDDIATSARDARARADHFFSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNT3</accession>
    <name>A0A367LNT3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">L249_2333</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNT3"/>
    <dbReference type="STRING" id="1330021.A0A367LNT3"/>
    <dbReference type="OrthoDB" id="1193027at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051735">
        <property type="entry name" value="CFEM_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37928:SF1">
        <property type="entry name" value="CFEM DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G14090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="6 15" id="KW-0349">Heme</keyword>
    <keyword evidence="10 15" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016869210" description="CFEM domain-containing protein" evidence="16">
        <location>
            <begin position="17"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="17">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="40"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RCI16096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="207" mass="20715" checksum="8F6FE71FC39DAB13" modified="2018-11-07" version="1">MKSAVFAVSLAAAVAAQGLPQCPTDCLNSMNTQKAESLGCQNNDFKCLCTKQDWVFGIRDCVAQACNNGQLVVDALNNAKNTCAQNGVQIDVNGINTSAGGPTVCLATSRRQTMTLTNALGPQNSGVVNAPPPTASAETTVATVFSTFSSGGSLASTPLVTTTIGAETTTTVTAGSTTSTSRGFAAQVTAAPAAGMLAAAGLAALMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPV5</accession>
    <name>A0A367LPV5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Non-classical export protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPV5"/>
    <dbReference type="OrthoDB" id="2365484at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024242">
        <property type="entry name" value="NCE101"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11654">
        <property type="entry name" value="NCE101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="58" mass="6379" checksum="44C19169C2BAF2E8" modified="2018-11-07" version="1">MPAPTYIISRVADPVFAVFIGISAAVTRINREEKSKGRTTSETIETGLRRIGFPKKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQB3</accession>
    <name>A0A367LQB3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome b-c1 complex subunit 2, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Core protein II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_2230</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase M16 family. UQCRC2/QCR2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQB3"/>
    <dbReference type="STRING" id="1330021.A0A367LQB3"/>
    <dbReference type="OrthoDB" id="6369905at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000021">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000039">
        <property type="entry name" value="Ubiquinol-cytochrome c reductase core subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF209">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="12">
        <location>
            <begin position="45"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="13">
        <location>
            <begin position="202"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI16608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="454" mass="48403" checksum="C9BCF1275A80FACB" modified="2018-11-07" version="1">MISRPLLARPAQQASRLSCSVRRRGFAAAATTAAFETTEISGLKVASRDVHGPTTKLAVVAKAGTRYQPAPGLTVGLEEFAFKNTQRRSALRIQRESELLGGQLAASHTREVLLLEASFLRGDLPYFAELLAEVLSMTKYTTHEFHEDVERVLPLKQAALRANVSSLALDNAHAVAFHTGLGAPIYPSPTAPVKKYMDEELIARYADVVYTKSNIAVIADGASSTDLTKWINQFFQDVPAFSQSGRGLNGEVSKYHGGEQRTEHADGNSMVIAFPGSNLSGSKPEIPVLAALLGGEPTIKWAPGFSLLSRAFYKTLNVSASASNLAYSDAGLLTITVSGDASRVRMATEATVTFLKSIAAGDIKDEDVSRAIANAKFEFLDRAQLRDPGMLLTGSGILTSGKPADLAAVANAFDSVKKDKMVATAKALLDGKATVSAVGDLFRLPYADELGLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQG3</accession>
    <name>A0A367LQG3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQG3"/>
    <dbReference type="STRING" id="1330021.A0A367LQG3"/>
    <dbReference type="OrthoDB" id="2414723at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31758">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN YLR108C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31758:SF2">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN YLR108C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="399" mass="42576" checksum="96F6D7158361651E" modified="2018-11-07" version="1">MTRCQWILAILPRLTSQLYEGSIFVSVGHREFQVPRDLLTSAINSPNFFSLSFAAFFTRPDSDVTTTTTTLTTRPHALAPPSAPNRSAETFAELLRLLKGYPVRIRDEAHRQDLLRDARYFRFKGLEQQLIPHAISFNPLRRREEIILRLENVQKSGVSVQQNDTGSAAYVNYARPYVDARPAELVLEIGGDATRIHWPAASAGGGRGPGAGGDGPRADFFGDTKARVARLFEVLATKLNMPLTTQPLGLLMASGGASSQPATPGNTPLSEDLVRVCLGPESAIVLDGRPLHCGGGGGGGGGGGGGGGRGGNGFSSDICGGFDFDNATRKRRRVASSSVGGPVEEEEVMVWAVRKGQWRLRIQACTGGKSSVECVLVAVKLDAVSSDLGRNLSRGFLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LR13</accession>
    <name>A0A367LR13_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glucosamine 6-phosphate N-acetyltransferase</fullName>
            <ecNumber evidence="8">2.3.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_1777</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="2.3.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the acetyltransferase family. GNA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.4" evidence="8"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LR13"/>
    <dbReference type="STRING" id="1330021.A0A367LR13"/>
    <dbReference type="OrthoDB" id="10039976at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000048">
        <property type="entry name" value="Glucosamine 6-phosphate N-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355:SF11">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="9">
        <location>
            <begin position="25"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI16858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="173" mass="19011" checksum="D353550043E862AD" modified="2018-11-07" version="1">MAADEGLFSAELIAPHVAGALPVGYKLRALRKSDYDGGFLDCLRVLTTVGEISKADFDAQFERMRRQEGYFIIVIEDDKAAVVATGALIVERKFIHNLSAVGHIEDIAVSKDQQGKKLGLRLIQALDFVAEQVGCYKSILDCSEANEGFYLKCGFRRAGLQMAHYYEGVGGKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LR40</accession>
    <name>A0A367LR40_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyltransferase family 8 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LR40"/>
    <dbReference type="STRING" id="1330021.A0A367LR40"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02537">
        <property type="entry name" value="GT8_Glycogenin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="40184" checksum="1D58E0B529FF00B7" modified="2018-11-07" version="1" fragment="single">PHLTSNSTSTSLPQPQPQPPVMTTPPPSLPINSKRVWTTLITNIDYLPGLLTLSHSLRHRAHSSYPLVALYTDSFPTNGLSALHARGIPYQRIPYLLPTTSRDYTEDPRFYDCWSKLAPFSLTEFDRVVQLDADMLVLRNMDELMTLPLDDTNDDDDDDDDDDDDDDDDDEPGTRVFAAGHACVCNPLGKKHYPQNWTPQNCAFTSQHTHPETAQTTAPDPSAGPLGFMNGGLQVVNPSQRLYRQILAHMESDAANMDFADQSLLSDLYRGRWFPLPYVYNALKTMRWPGVHDAIWRDDQVKNVHYILSPKPWHELDDDGNWTGSDETHRWWVDANRERKALEREQNIAQDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRC9</accession>
    <name>A0A367LRC9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein-sorting-associated protein 46</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRC9"/>
    <dbReference type="STRING" id="1330021.A0A367LRC9"/>
    <dbReference type="OrthoDB" id="10266568at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="205" mass="23041" checksum="378C41FB65DB12A0" modified="2018-11-07" version="1">MSNRQLARDMQVEFQARFQAKQARREATKAAKQDPLLRKQIQDLLKKGETQKAYQKAKMLLSKQALAQQMDQMADMAELSAAQIQANNTMNRMTHMMGQSSRTMNAAQRNTNPEKTLVTLEQFKQQNEDYAMSNGIYQDAITQSTSVQVGEDAVHELLGKLADDAGIELSQELNKATPSAAEPQTNEPSAEEEDKLQQRLRALRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRT3</accession>
    <name>A0A367LRT3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA polymerase II transcription factor B subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_2595</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the TFB2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRT3"/>
    <dbReference type="STRING" id="1330021.A0A367LRT3"/>
    <dbReference type="OrthoDB" id="364513at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040662">
        <property type="entry name" value="Tfb2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004598">
        <property type="entry name" value="TFIIH_p52/Tfb2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00625">
        <property type="entry name" value="tfb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152">
        <property type="entry name" value="TFIIH, POLYPEPTIDE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03849">
        <property type="entry name" value="Tfb2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18307">
        <property type="entry name" value="Tfb2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor Tfb2 C-terminal" evidence="10">
        <location>
            <begin position="468"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI17121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="539" mass="60015" checksum="D04BF1A712DDBF58" modified="2018-11-07" version="1">MTANFNLPLLKPIPRPEARTVLRRRRKMAANPLQTFQLGEYLEKLPGTTFRKLYQQPSTALCIFRRMLPHLAKTLVLRCLWMPAPLPLSVLDEWVRPEAKQQRDQALSVLRGLHIIQITAPSKEKPQEMNLTTNFRSSMRLALTGGGTHNSFGVPSTLLVPPEVDVTFLDRYARKRWDDILHFVVSSVGFRSAGEVSGPNKSVKELLIAGRLVDRRPNGGIGITRSGFTFLLQEANAQVWTLLLLWLEASDLNKAAGFETVDMLCFLFVLATTELGKAYDTNALTEQRKNMLPSLIDFGLIYIPQHKRSMFFPTRLATTLTSAGSGSLRSISDGVAAVTAAAAAAAAAASTNNNGNGIANGSQSKLVGQQQSGGEQQKGSVIVETNFRLYAYTQSTLQIAVLALFTKLNMRFPDMVAGRISRASIRQAINFGISADQIISYLAAHAHEQMHRASTLSNKPLLAPTVVDQIRLWQLETERMKTTGGFLFRDFDDQKEYLDTARFADEIGVLVWRSDKSGMFFANKHEQIRDYLKSRKRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LS12</accession>
    <name>A0A367LS12_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LS12"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI17233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="109" mass="11956" checksum="C123243E77EF3C9A" modified="2018-11-07" version="1">MHGVVAHALAKEKGPKEGRFGKRPFLMPPAVNFGPRPGRKEDPAEKKKKKRNRCIEESVTAAVNGSCVNFGCHRRRLLPREGVHSLCFATHAPPPPLFSGRLSMSTISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LS76</accession>
    <name>A0A367LS76_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_3237</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LS76"/>
    <dbReference type="STRING" id="1330021.A0A367LS76"/>
    <dbReference type="OrthoDB" id="5570009at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004771">
        <property type="term" value="F:sterol ester esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23025:SF3">
        <property type="entry name" value="HORMONE-SENSITIVE LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23025">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="403"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="654"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="549"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="821"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="564"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="583"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="612"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="642"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI17305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="889" mass="98671" checksum="D24BF396E76DF38A" modified="2018-11-07" version="1">MVGSTEGGQDWLRAVSDGGQDPGYCYWGPGERGGGGRGERWDEENLLSLQRHSRLIAGAHVTKQESKKGTMRRDHVLVDNSSVITKGPKLQRVGLYIHGPKCAIKISLIDTHSLKIHDSIPQLPVPFFNPLEPLQRTKVCLHMLPAPSAPAQAGSPAFFFKRPLLQASPAMRSTRNNKSAAAIMIDHVLGRPSSKSRRLQVLAVLSFWSLYLAKGPSHGPPVLQRLSRMLSKRMTPWQAFLATLVYLYATRNFSALAGLASPEPMTNMYDAAYFRATWVLTALDAGFWTAMKIRTKWLRDIAGMVFSLYYLVAAERADEKVRKIRACVTVEHLRVSWNKPTTPYVGFLQRLVRPRLTRWSPRQLRIPRPPNSDYTEPVSAWLYYDGPLADLERHNRIILDMPGGGFVSMNPRCHDDRLLGWASKTGLPIVSIDYGKAPEYPYPHAINECFDAYVTIVRTQGRCIGLSGREPPQIALSGDSAGGNLAVATTLMVLETGSPSFRRCPTQASLPVPDGLVCFYPTLDMNIGNWMSDEQMSLIRDREMNKPIVRRKSRQYEELVGTPRRTDDRSDDDNVKVNGHVDNDDDDDDDDDDKAPKVNGSLAVDDNERLSRASTVTSPHATQPEYSRSGPQVLDTSAQSPTKRESVSHRAEPMKTRLATSSMISYFNDRILGPEMMRAMILLYIGAHNRPDFSKDYLLSPVLAPESLLAKFPKMFLMTGERDPLVDDTVVFAGRVRRAKEAAGEDAAKAVEVTLLPRISHGFMQFPSVFPPAWKYIERSASWFDQIFSEAEEARNPAARPMSESGAEEDRPLEMMSMTKMRRGGSSLSPSATTDRKTTSGSGRGGKAPKRPGLNKKNSLVRLNSADDLLGRRMQGLASALAGNTGDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LSE1</accession>
    <name>A0A367LSE1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_1991</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LSE1"/>
    <dbReference type="STRING" id="1330021.A0A367LSE1"/>
    <dbReference type="OrthoDB" id="4489171at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055335">
        <property type="entry name" value="Ucp6/RUP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39597">
        <property type="entry name" value="UBA DOMAIN-CONTAINING PROTEIN RUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39597:SF1">
        <property type="entry name" value="UBA DOMAIN-CONTAINING PROTEIN RUP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="197"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="803"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="640"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="228"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="807"/>
            <end position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI17331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="920" mass="103513" checksum="B2FB065157774CA5" modified="2018-11-07" version="1">MASLDNIQKLQKWGSNYDAWLISLTGVAMMNGQYDYMVGRVPHRAISGQHEIWLKEDQRAVGLLLLSLSIEAAKDIVSLGWVDGMTAAETLRLCKHADAWTVKALKPITMTSKEPSEAEISQVLDFASLDPQEDRSMSPFRQKSSTGTGLRRWQFRSKFSRLWNDNMFSADRDGSDNVTGSSFHIESMNQNDIILGVTPPADGCGVGAPSRPPSRSNDRSPLGGTNSHSREDEDMQRALRESAQEAGIALPQQESGILDASTSEPYFGPANRNDYEQANWAMVPTKESSKAAAASAPEQRKRAPGAPALLIRGPGSNGQHCLGGLLTILHEIPLARNIVLDNGRAADSYGFNSEWWKGQEILKPHILNQLQAGEVGWAERHGPSSNREEELHRLMAFLDSTDRSYGSVGVLLDLLQHNSISGLPPEKRLFEYLIQECSEPMLPLTQVADLVPVYGSSDHEEKVRFGILEMIHSRVEYDHIKTLYESLDHVFWDSLKAKELAQDSKMGLFQHMAEVLIISVGGEGPPESIEIPEELYPERYLASRKHEAQQIQRAWCETKQALRRVEEREEDMLEWKLDWNESLSKRDTLQKVMDRCATYRQYLESRGRFRAMEASGFDTDKYPDYRAAPNQMMEEERGRLEEVDAAFRLAEESLADLEGQLKAICVEKDRIKAKQRRIGKALTVPNKAGRPKPMTCKRYLLRGIATPNDVVYLRQPPEPDLIQLDDGEPPSPDQWWKLAYSPKNSSEDEVRAEKVTTEHVLADVWQETKTPLIIYATEEAIEKAKAPLPASLERFVRADNKAFQQELSRERSEDQQMEEKSPSKRKHRADSIDSNHASLGSVDMERSSETEMADLSDARIGGLGPEPRQQTGPEMQERHRSLTLPTTSPPKGQGTIDLELPDYHEYVVDKRSGAGMDAWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LSN2</accession>
    <name>A0A367LSN2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">OPT family small oligopeptide transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_2656</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LSN2"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="262"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="501"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="529"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="559"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="608"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="640"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="674"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="703"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="755"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI17465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="810" mass="92784" checksum="13F02BE3F9266346" modified="2018-11-07" version="1">MKQVLAEHENDPNFHHTTIQNIKAFLANEDMMRNPDRYEQAVDRIKLEAALITTNSPYAEVRANVDNHDDPSVPVSTIRAWTLGCLFSVLLSFVNQLFSIRQPYIRFDTNIAQLLSYPLGKCWERWLPSYEMTIPFTKGAKVNLNPGPFNKKEHMLIAIMANTSKSLPYTNFMIWTQVLPQYFNQQYARSTGYIFLNAFATNFIGYGLAGIMRNVLVRPSYCIWPTVFSTIALNAALHPSSESERCVRGPMGTTWSMSRYRFFLYTFSAMFVYFWFPNYLFQALSYFSWMTWIAPDNLKLNILTGMQNGLGLFNPLPTFDWNVITYVIDPLFQMMPSFTTFNAVAGMFLTGLIVPFVWFTNTWNTGFLPIISNHVHDHFGKIYNVSNTLDSRGMFDRDKYAQYSRPYLSATRALSYGWNFAIYTAIMTRVVLYHRPQMVMGFRSFFKNLRFRRKTTTDHEAKEEQYSDVHSRLMSMYSESESRLHLVHPKPSLTDRVVPEWWFFIILAISVVMGILGIVLWPTYTSPAVVLYGILLCLIFIVPIGVTASMTGLEITLNVLAEFIGGVIVEGNALAMNFFKSYGHVTTKAPCPELEADHHRQLPPRVTFMGQMLATLISTIVCTGVFKFQIDIKDVCTPKASMRFFCPGPNTFMTASVLWGTIGPVKVFGKDGYYKWLLMGFPIGCILVTLVWMLQRRWPDSRMLRQVNVVVAIAGSLSWAPYSFSYAWPAVPFAWFSWIYVRGRHLDFWSKYNYVLSASLSAGVAISAIVMLFTVQWAGIAVNWWGNTQPYKGCEGSPCLLYYLAEGEHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZ26</accession>
    <name>A0A367KZ26_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_3777</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000029">
        <property type="protein sequence ID" value="RCI07429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZ26"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI07429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="57" mass="6501" checksum="75EB5EC7DB0C204F" modified="2018-11-07" version="1" fragment="single">MLMILPSRWENPPPFIDNFSGIKTCSDLTDLIDLINPIDPIDLTRYNRYNVPAIAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZJ6</accession>
    <name>A0A367KZJ6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vacuolar-sorting protein SNF8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_1641</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the endosomal sorting complex required for transport II (ESCRT-II).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SNF8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000026">
        <property type="protein sequence ID" value="RCI07595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZJ6"/>
    <dbReference type="STRING" id="1330021.A0A367KZJ6"/>
    <dbReference type="OrthoDB" id="283883at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000814">
        <property type="term" value="C:ESCRT II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000397">
        <property type="entry name" value="Vacuolar-sorting protein SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016689">
        <property type="entry name" value="ESCRT-2_cplx_Snf8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040608">
        <property type="entry name" value="Snf8/Vps36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806">
        <property type="entry name" value="EAP30 SUBUNIT OF ELL COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12806:SF0">
        <property type="entry name" value="VACUOLAR-SORTING PROTEIN SNF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04157">
        <property type="entry name" value="EAP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017215">
        <property type="entry name" value="ESCRT2_Vps22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR017215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI07595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="259" mass="27756" checksum="0AE5C39F6F4C925F" modified="2018-11-07" version="1">MSRKGVGIGAFDRSRLTSQHYASHGSSLRASNASALASQLAVFRALLQQFAQTHAKDIRSDPAFRAQFARMCTAIGVDPLASGDSGGGSIWAQLLGKTVNDFYFGLAVRVVDVCGATRGENGGLIGLRELSDRLSGQQAAAAAASSNGGADITEDDVRRAVETLKPLGGGYGIVRVGRKDYVRSVPRELSSDQAAVVEAVQVLGYVSVAMLRDNLAWETARCHTVIDDLVAHGMLWVDKQTRGEWEFWSPSFMVHADQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZL6</accession>
    <name>A0A367KZL6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_1654</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MOG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000026">
        <property type="protein sequence ID" value="RCI07615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZL6"/>
    <dbReference type="STRING" id="1330021.A0A367KZL6"/>
    <dbReference type="OrthoDB" id="10255285at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.10">
        <property type="entry name" value="Mog1/PsbP, alpha/beta/alpha sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007681">
        <property type="entry name" value="Mog1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016123">
        <property type="entry name" value="Mog1/PsbP_a/b/a-sand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837">
        <property type="entry name" value="RAN GUANINE NUCLEOTIDE RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837:SF0">
        <property type="entry name" value="RAN GUANINE NUCLEOTIDE RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04603">
        <property type="entry name" value="Mog1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55724">
        <property type="entry name" value="Mog1p/PsbP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI07615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="196" mass="21795" checksum="D4A4CBAEB5C4FB23" modified="2018-11-07" version="1">MPYRCTPLYGGAMVCDLPDNFADVSKLRQVPDNQEVWIDKDGFTSIIFDITERVGGPGSGPEIDGRAMTMHLEDMVGTDIDSVKIWNTAETEFTRLEFKPPAYTLIATQTPKVGHSRGQSSAPDFTAIIMTLLRLEQYKTDILITINVPHIKGEYDEGDVDLELGKQGKLMGNAVEYSASIWESLKIKDFSLFGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L073</accession>
    <name>A0A367L073_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Chromatin structure-remodeling complex protein RSC7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_5777</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000023">
        <property type="protein sequence ID" value="RCI07828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L073"/>
    <dbReference type="STRING" id="1330021.A0A367L073"/>
    <dbReference type="OrthoDB" id="5598844at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013933">
        <property type="entry name" value="CRC_Rsc7/Swp82"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597:SF3">
        <property type="entry name" value="CHROMATIN STRUCTURE-REMODELING COMPLEX SUBUNIT RSC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08624">
        <property type="entry name" value="CRC_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="26"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="158"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI07828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="556" mass="60037" checksum="DEB4CD73EE55C470" modified="2018-11-07" version="1">MPSRRSGRAAAKKAAAALDNSQPSAMDDEDEGEGEGEGEGEGEGEGEGEGEGEGEGEGEGEGEGEGEGEGDDEEEEEDDDDGDGDGDGDGDGELPEAKGGDDDTGAVKGEGSTNNPRPPPPPPPQPIVRKKRLGRPPKNRPPDWDREAATANDDTPRRRGRGGWRGRGGRKGGPAVPKAEQVIDADGTVAEIVGDECVLPGDPEGETKVDAMGNLAGGRDYRCRTFTILGRGNRLYMLSTEPARCVGFRDSYLFFTKHRKLYKIIVDEDEKRDMIERDIIPHSYKGRSIGVVTARSVFREFGARIIVGGKRIADDYNVAQARADGVVEGELANPDDHFVPGEPYNKNQYVAWHGASAVYHNNAPSGPVPSSKTEYRKRKANVNDTNWMLEHAREASIFNSGINAIRKLNNAGVYDIHTNLVQYPAIMQPTLARIEQVPLGDEPTTSKEDGESFPPAPARLVRNFLVVDTYMEGPPAGASATASGKAVDSADLLTAFNGLAAVSDEIRDLLPTECRAAFDKALERDREWKARWGPESEKTSRRNPIIDKAIVPYTMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L133</accession>
    <name>A0A367L133_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L133"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="86" mass="9462" checksum="0A4CB6EECC171DAC" modified="2018-11-07" version="1" fragment="single">MMKLYSIIPTREGGGRFNLYLAAVCLRLSINANAGRRRPVGRKDHEATTFPSGKTGNGTGIHPQEEKKALLESGLEELEAVVRIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L221</accession>
    <name>A0A367L221_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_8792</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L221"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI08458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="141" mass="15903" checksum="B8607794ECD74C63" modified="2018-11-07" version="1" fragment="single">RVGRPPLLALLIRVSRIPISNLSSKTPRNRETLNPGASWRFGLYAPSTQISVILNYSELDPGCLCLDTGTYGYGYRLAYPRTYTLLFYSLRIPPLAQRLPGLGLISRLPFHPSLGDLLRPAYNGFRLYRLSYPQPSHNDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2D3</accession>
    <name>A0A367L2D3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Heat-labile enterotoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_4735</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2D3"/>
    <dbReference type="STRING" id="1330021.A0A367L2D3"/>
    <dbReference type="OrthoDB" id="4917243at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.210.10">
        <property type="entry name" value="Heat-Labile Enterotoxin, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046533">
        <property type="entry name" value="DUF6598"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001144">
        <property type="entry name" value="Enterotoxin_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33065">
        <property type="entry name" value="OS07G0486400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33065:SF88">
        <property type="entry name" value="OS11G0104220 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20241">
        <property type="entry name" value="DUF6598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01375">
        <property type="entry name" value="Enterotoxin_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0800">Toxin</keyword>
    <keyword evidence="3" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016794138" evidence="6">
        <location>
            <begin position="22"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6598" evidence="7">
        <location>
            <begin position="430"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="400"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="413"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI08593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="674" mass="76640" checksum="3AA21229FDFEFC9A" modified="2018-11-07" version="1">MRGLTALTLAGHFWLVISSEAKSLSRRQARNHVNLVYRGDDRTPWEVREAGGFRPWGEGWGDESFFRIDRHYNAGPSGCGRQDFDDPAFFWRTAYVSLATDRHKASKYGVWLYEIRATPNILDGANADGEVMALGGVHWRQIRRYTQMRDRTGLEDRVDDSTWLDNPEYDFQLYEWSSWSALCGLSMDYPDVLESGVVGPGGMDAMRAGHHFMTNTMGMRELYGNFPPQFEQYQPNYDIPRPSFASLPPWEEDERRLRLFLDAEMQNLPGQCQQALQDAFVWGLDQNSCDMAIRSQVAAICGVPAGGPIKRPCCNMAASLEMATHMTFGLQPMQGSCSDSRRAERFWQTAEWYQGSDRELLRNLFPQLGIDLIHTLADGTNDGPNDDLWDYEGSWGNGPRRGFSSNDYDRNEGSWNRGNQQPNREVGRPMAQISSVVVHNIDNENPGNLFGQIKVTDRLGEQTIYKVGADNAQLIHPGEKMKLEGPKRPIEADTTFFIDFDLWDWDEDWSSNDKIGAGRFTWDVTSPLAAYDKMVQRTIKGPRGEVSMELMAIRNAVAARVDIFIMNGDDENPVNVFGKVRVTAKHFDYLVFDRADDDYRDVVPGESMPLIANMFAMPLRQSMKVRLDLWDYDSSSANDEIARETLTFWPQVGGKSRQTAKGTYGRVDVEVTWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2E8</accession>
    <name>A0A367L2E8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Cysteine proteinase 1, mitochondrial</fullName>
            <ecNumber evidence="2 9">3.4.22.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_4754</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity.</text>
    </comment>
    <comment type="function">
        <text evidence="7">The normal physiological role of the enzyme is unknown, but it is not essential for the viability of yeast cells. Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity. Acts as a repressor in the GAL4 regulatory system, but this does not require either the peptidase or nucleic acid-binding activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>Inactivates bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a carboxyamide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred.</text>
            <dbReference type="EC" id="3.4.22.40"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homohexamer. Binds to nucleic acids. Binds single-stranded DNA and RNA with higher affinity than double-stranded DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.40" evidence="2 9"/>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2E8"/>
    <dbReference type="STRING" id="1330021.A0A367L2E8"/>
    <dbReference type="OrthoDB" id="2666448at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070005">
        <property type="term" value="F:cysteine-type aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043418">
        <property type="term" value="P:homocysteine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00585">
        <property type="entry name" value="Peptidase_C1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004134">
        <property type="entry name" value="Peptidase_C1B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10363">
        <property type="entry name" value="BLEOMYCIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10363:SF2">
        <property type="entry name" value="BLEOMYCIN HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03051">
        <property type="entry name" value="Peptidase_C1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005700">
        <property type="entry name" value="PepC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0788">Thiol protease</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="13"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="421"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005700-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI08577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="502" mass="55876" checksum="6F7DECE61C81F2B5" modified="2018-11-07" version="1">MGGQPSKSSNMPTRERKTAAAEGACRDTDKVYDEKKGRRPVEERPAEELPLEVVAARPERILEDPKNRLAMRALSSTNPQQVLSSPAAKAADQQVFNVRIPSEGAPITNQRSSGRCWLFASTNIFRIALMSKYQLDKFELSQAYLFYWDKLEKANWFLEQALDTTKEPLDGRLMQTLLGDPISDGGQWDMVHNLVDKYGLVPQSLYPDSWNAQSSGTLNTVLKHKLRESTLRLRRMASDEGASAAALGEAKDKMVAEVQQALTLLLGPPPSPTEAFRWQYQDRNGRGHELRIKPRDFARQLDGNGVRISSSTIDGMVSLVDDPRHEPLTLLTVSRLGNVVGGRPVRYINVRMSTMKSACVQMLRAGLPVFFGCDVGKFGDRSTGILDTGLIDYALGGLSSDGLLGMTKAQRLRTGESQMTHAMVLTAVHVDEESGEPTRWRIQNSWGKDTGSEGWYVMSDAWMDAFVFQVVVEKRFCSNEVRRVLDQEPVVLPPWDPMGSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2G3</accession>
    <name>A0A367L2G3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Beta-galactosidase</fullName>
            <ecNumber evidence="3 8">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_4730</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3 8"/>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2G3"/>
    <dbReference type="STRING" id="1330021.A0A367L2G3"/>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.102.20.10:FF:000001">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000065">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000040">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.20.10">
        <property type="entry name" value="Beta-galactosidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.390.10">
        <property type="entry name" value="Beta-galactosidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018954">
        <property type="entry name" value="Betagal_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037110">
        <property type="entry name" value="Betagal_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025972">
        <property type="entry name" value="BetaGal_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036833">
        <property type="entry name" value="BetaGal_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025300">
        <property type="entry name" value="BetaGal_jelly_roll_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019801">
        <property type="entry name" value="Glyco_hydro_35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13364">
        <property type="entry name" value="BetaGal_ABD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10435">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13363">
        <property type="entry name" value="BetaGal_dom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SMART" id="SM01029">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117100">
        <property type="entry name" value="Beta-galactosidase LacA, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01182">
        <property type="entry name" value="GLYCOSYL_HYDROL_F35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016786515" description="Beta-galactosidase" evidence="10">
        <location>
            <begin position="19"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase" evidence="11">
        <location>
            <begin position="378"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI08598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1008" mass="109648" checksum="E6297132D62739C5" modified="2018-11-07" version="1">MKPSTTLLAALALPLCDAFSLAGRPVNLVEVDKRAPLQNLVTWDDQSLFIRGERVFMFSGEFHPFRLPVPSLYLDIFQKIRALGFNMVSFYVDWALVEGKPGEFRAQGIFDLEPFFEAAKEAGIYLLARPGPYINAEVSGGGFPGWLQRINGVLRTDAGDFLGKTDNYMANICAIIAKHQITQGGPVVLFQPENEYSYGKDIPFPNGNYMQYVIDQARKAGIVVPMINNDIGPVGYYAPGSGRGAMDIYANPSIWPFYKFHTDRHLLHMMYSPSTPFSLVEFQGGSYDPWGGNGLDQCAALINHEFERVYYKNNIAAGVRIFSLYMIFGGTNWGNLGHPGGYTSYDYGACIRENRVVDREKYSELKLEAEFLRVSPGYLVTTAGNTTKGVYSPNENITVTPLLAQNTASFFVVRHTDFANTGSTAFTLRLPTSAGILTIPQSGGALTLLGRDSKVMVTDYPVGDYSLLYSSAEVFTWKKFAADKTVLVLYGGRPGETHEFAVRGDGQQQVRLLEGDDGVMANLLAGVAVVVKWKTTTGRQVVKIGHLVIHLLDRNSAYKYWVPVLPSNGSSYGSSVMNPESLIINGGYLIRSAAINGPRLSLKADFNTSTPLEIIGVPPGVSQLSVNGQQTRYSVSALGDWIAEPDIGIPKVFVPDLSALPWRRIDSLPEIQPGYDDSAWPVADKQRSSNSAFPSTTPVSLYGSDYGFHTGTLVFRGHFTAKGNEASLYLRTSGGTAFASSVWLDGTFVGSFKNAEVADDNNSTYRLPPLTGNNDVGAHHVLTVVVDNTGLNEVTNSGTETMKAPRGILSYALLSSDGRPSGTEISPWKLTGNLGGEDYVDESRGPLNEGGLFFERQGYHLPGPPGSEFDKGSPMEGLRGAGITFYAAPLTLNYPDKYDIPFTTRTSSSSSSTFSTATKSDYRATLFVNGFQFGKYASNIGPQSEFPVPEGILNYRGTNWIGLAVWALDPSGAAVPTFRLKAGTAVVTGREPVYLVNGTGYSHRPGAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2L0</accession>
    <name>A0A367L2L0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_4661</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2L0"/>
    <dbReference type="STRING" id="1330021.A0A367L2L0"/>
    <dbReference type="OrthoDB" id="1854502at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030011">
        <property type="term" value="P:maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13292">
        <property type="entry name" value="PH_Osh1p_Osh2p_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000281">
        <property type="entry name" value="Oxysterol binding protein (Osh1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000008">
        <property type="entry name" value="Oxysterol binding protein (Osh1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000061">
        <property type="entry name" value="Oxysterol binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF205">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="5" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="287"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="10">
        <location>
            <begin position="378"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="109"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="494"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="720"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="675"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="501"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="525"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="580"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="728"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI08670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1224" mass="135960" checksum="5FA499A271864088" modified="2018-11-07" version="1">MSDAAERQVDPSHRRSMSAAAFSILRRKGEARDEDSGSEDGRSIKSPRKQASQQPLARGHVSKPSTAKARSPQPPSLLRPVPDKTVSLEQSMRKFRVVEALRSGDTASISRAMRDNADTGRRPSNASVSTMGSASTSGLSPGPLLDTTVLHLAIQCAELPVVEYVLSNGLGVDVNARDKDGNTPLHVAAINGRTPVVKMLLERKDINDAVANAQTKLPIDVARNPEIFQLLQLSRSLFTEAKVAQVQGLVARRDYDDLARVLEEPRLKTVLDINSPEFASEPVTVRSGGTLLHEAARNKDTRLIEVLLLHGGDPFRRDRKGKLPQSVTNDDGVKAILKNSPAAVAAQRGIQEKAVLGHAASNVISPTGAADLMAGKEAREIKGYLKKWTNYRKGYQLRWFVLEDGVLSYYKHQDDAGSACRGAINMRIAKLHMSADEKTKFEIIGKSSVKYTLKANHEVEAKRWFWALNNSIQWTKDQAKEEERRAARTAEFLKQAKAEQSSSLSVHDSHSESASLSDLRRNPSHAPSRSLSHARTPTAGSVDDDDEELTGVGTEGDAASRAPAQTLAGDQADDDDDYDERSVREEPGATKDALNITAQSAKIQLETMSAVHTALQADLAHNPSTPLSDAKVTQALSTYDEATRSLTGLVGDLLRISRDRDGYWQYRLDREANMRRMWEESMQRVAREQEELEARMGETESKRRLTKKALKEVMVAGGVGSANQTPTVEKKQSEAEVDIKSVQSQGRRGTALDQLGQLSESESETGDEFFDAVDAGEVEVEPLPADEPSDETDGVIVSGVDISSSFRGYENGIRHRLKMDADDRPKVSLWGILKSMIGKDMTKMTLPVSFNEPTSLLYRCGEDMEYADLLDRAVDRVDSMERLIYVAAFAASEYASTIGRVAKPFNPLLGETFEYVRPDKNYRFFIEQVSHHPPIGAAWAESPHWTYWGESAVRSKFYGKSFDINPLGTWFLRLRPKAGGREDLYTWKKVTSSVIGIITGNPTVDNYGPMEIKNWTTGEVAYLEFKPRGWKASSAYQVVGKIVDSEGQVRFSMGGRWNSKIYARLTPGFEAAVEEPKDGGVDGSAGLTDPNRAYLVWEAHDRPAGIPFNLTPFVLTFNHIDDKLRPWLAPTDSRLRPDQRAMEDGEYDVAAEEKNRLEERQRDRRREREARGEEFVPAWFSRERCPITGEEYWKFSGKYWEQRDMAGPKGDPEKAWAGLEPIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2N6</accession>
    <name>A0A367L2N6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_4857</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2N6"/>
    <dbReference type="STRING" id="1330021.A0A367L2N6"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071821">
        <property type="term" value="C:FANCM-MHF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22919">
        <property type="entry name" value="HFD_CENP-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000020">
        <property type="entry name" value="Peroxisomal ascorbate peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029003">
        <property type="entry name" value="CENP-S/Mhf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051836">
        <property type="entry name" value="Kremen_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002207">
        <property type="entry name" value="Peroxidase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269">
        <property type="entry name" value="KREMEN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269:SF16">
        <property type="entry name" value="PROTEIN SLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15630">
        <property type="entry name" value="CENP-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00459">
        <property type="entry name" value="ASPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016595658" description="WSC domain-containing protein" evidence="9">
        <location>
            <begin position="17"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="10">
        <location>
            <begin position="103"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="11">
        <location>
            <begin position="578"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="11">
        <location>
            <begin position="689"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="11">
        <location>
            <begin position="796"/>
            <end position="888"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI08684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1009" mass="106510" checksum="138EB8636E1E18FD" modified="2018-11-07" version="1">MRSSLLLLTVGALALADPTWPAETDELEEIMYQLFSFGARKFADTISPCSNEASGPGRQNAAEWLRTAFHDAATANTYFGTGGVDGSLQYELDNGENTGPGHKTTLEFMAPFMSPRASLSDLIALGVYASVRSCGGPVVPFRAGRRDAAAAGSPGVPQPQNSIFTFQQQFERMGFSKEEMIQLTACGHTIGGVHQSEFPDLMPNTGVRNGEVPSDSTVDKFDPNIVTEYLAGKTDNPLVGGPSIKLNKNSDFKVFNSDGNKTVRAMADPEAFRATCAKVLQKMTEVVPPGVTLSGPVTPYAVKPVGLQLTLIDGGSSLGWKGYIRVKTPVGGGIESISITYKDRKGGCAGGSSSSSSSCTIESTIQGVGRGFDDSFAFFPIEASIPASRGISSFVVTLRGADSSASTLYDNNGKGYPVQDDVVFQAPQSCVRPSSGALTVAAAVRNDVAAGGARADVWYREPQSNSPVPRLSRAQVTLEKGRCVGHYTLFATDYAVQGGLASQSHVDVSAGSSVDGFKSLADVGGTCAEFERAAPCVAEKPALKTLTGRAVFTTASSTAAVVPTTTPVVAQHRSAVGGYRLVSCWTEGNRTRALDAATFINDTMTLDKCEAFCSKYNYWGTEYGRECYCGNSLSSSSKTAPLSDCNMPCGGNGSEYCGAGDRLELYSTTSAPVTPTPTATLTHKPTVSPYTLVGCYAEPPSARALPQKTSMDSKTTTNDACAAACAGSRYFGTEYGGECYCGSFVNGGAKAAPLTDCGMPCAGDQYQYCGGADRLELYENANATGGTPQQPPTVADFALVGCRTEGNGTRALAGRAAAADDMTNARCAGFCVGAAYFGTEYGRECYCGDVLDSSSREAPAQECGMLCAGDATQLCEERASAYDDGGAAWVAGEASSCSHDDRRDDGRVGPRAYEFKRLKSALWFAVGQIVDEESMRRDLNATPQFIGALTELVWTQIENVAIDLESFCHHAGRSTVTTADVLLLARKNPDLQLLMESFVESRKQARKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2V6</accession>
    <name>A0A367L2V6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cystinosin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_4884</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2V6"/>
    <dbReference type="STRING" id="1330021.A0A367L2V6"/>
    <dbReference type="OrthoDB" id="75720at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015184">
        <property type="term" value="F:L-cystine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005282">
        <property type="entry name" value="LC_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13131:SF5">
        <property type="entry name" value="CYSTINOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI08755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="32690" checksum="FFE947F83E256163" modified="2018-11-07" version="1">MVAFLPLLSSLFGWTYTLAWSGSFYAQPLLNYRRRSTSGSTVDFPFINTLGFAAYLASSAALYLSPLVRSQYASRHKGLEPTVQANDLIFALHALVLSAITASHYLLRESWGFAPSPGTKPSRFILAIAAGCLLALAFIYVLTLTRDPNALPDVDDVAGSSGWCELDLVYAAGYVKLVITLVKYSPQVLANARNRSTVGWSIWQVLLDVVGGVLSMAQQAIDSYLLRDWSGITGNPVKFALGNASLVYDSIFMVQHYVLYPPSRRGLERDPLLLGEHHEGPIRDDEESLRRQRRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L367</accession>
    <name>A0A367L367_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zona occludens toxin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_4989</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI08864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L367"/>
    <dbReference type="STRING" id="1330021.A0A367L367"/>
    <dbReference type="OrthoDB" id="2316594at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI08864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="507" mass="54806" checksum="EA13974F0BC12011" modified="2018-11-07" version="1">MKQAITKINPQDDDPDLTTHLSLLSLQQDDDDDNQDAISSSQLTTSPVFTQEVRSSNKAAFSQYGLLGGHAVAAAITTTTTASQPQHQDPRLFYNVSAPSSVFICGSQGSGKSHTLSCLLENCLVPCDANVLPKPLTGLVLHYDAFVSDVGGSPCEAAHLSSSRAVQVRVLCPPTNLVRIRNIYSALPNLTVEPLQLDERDLNTKRMLDLMAVSSSTQAGSAAAGGGMPLYLHVVTRILRDLRLEQQLTGGGFDYAKFKSAIANEAMTPGQMAPLQQRLDTLQSFMVKEQVTKQKTKKKTTTTTTTTMKRGISWSPTPGQLTIIDLSCPCVTADAACALFTICVSLFLEQPSETTGRVVALDEAHRYMNQCEGSASGSLTETLLAAIRLQRHIGTRVIISTQEPSISPKLLDLCPVIVVHRFSSPDWFRALKRHVATGDDDDDDDHTPTTGLFRSILALRQGEALLFAPEAIVVATSSKLTMLGSRAIKIRVRKRLTADGGRTVMAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3H1</accession>
    <name>A0A367L3H1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAM50A/XAP5 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_5013</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI08981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3H1"/>
    <dbReference type="STRING" id="1330021.A0A367L3H1"/>
    <dbReference type="OrthoDB" id="1562195at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048337">
        <property type="entry name" value="FAM50A/XAP5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007005">
        <property type="entry name" value="XAP5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12722:SF0">
        <property type="entry name" value="PROTEIN FAM50A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12722">
        <property type="entry name" value="XAP-5 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04921">
        <property type="entry name" value="XAP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM50A/XAP5 C-terminal" evidence="2">
        <location>
            <begin position="171"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI08981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="374" mass="42246" checksum="4EC794C09A0BD827" modified="2018-11-07" version="1">MADQVSARFTPQNKTTHERLSNHTVGLVALSDFRKRRAEVLEQQEREAREAALAGTSSSAVSAAESETLASGGESGSAPAKRKKKEKKPTHRGKNLLSFDDDDEAEPSPTDDKPSTSTDQASAREEARLRANAAVAIVPRPVTKAALRKEATEREALRLEFLSLQEAVKATEVAIPFVFYDGAHIPGGTVRLKKGDFVWVFLDRCRKVGVGRHGHNQHHHHHHHHHHHHHHHHHHHHHHNHNHNHHRRGWARAGVDDLMLVRDTIIIPHHYDFYYFLMNKILGPSGDRLFDYSADAPPEPDASHSEGLAPTPSNISTLEGAADDPRRTKVVDRRWYARNKHIYPASTWQEFDAERDYANEIRKDTGGNTFFFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3H4</accession>
    <name>A0A367L3H4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI08983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3H4"/>
    <dbReference type="OrthoDB" id="4915430at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016743430" evidence="1">
        <location>
            <begin position="22"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="353" mass="40807" checksum="9F604EB12BE2EC08" modified="2018-11-07" version="1">MSLFTVLLFLLFLLLITYTNGDTFPEQIQKNLLKKLEDRAQINWDNPPYSEESHTPEPCRFFFRSVLSWKLRRQLKRNAGDKVQIENDAISQKRFLNDDRAPMTMRQEDSEWDIEGVSKSWHAGATYSLGKLDVSGGTAHSKFEQSMKISGRNLEKSCPGGHECHFQELVYYARWTGLCKTEVFNKRGADICLTPVAWKRRNRRPKAKTCSRILPYHLCSTRLRCSLRLPIRDANGLPLSTTLFVKESYITVPKAVSVDDRCVFKLDNGKWYDSDADIFWTRYDYYDDGRTQRWVLRDMDEPIPLIADSLLGNCTLPADDYMRKRDLDGARHRRVKRVVVDVVGGFGLGSAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3I5</accession>
    <name>A0A367L3I5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription factor SWI6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_4992</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Transcription factor that plays a role downstream of the MCK1-MKK2-MPS1 cascade. Required for hyphal morphogenesis and pathogenicity. Is an important oxidative stress response regulator and plays a positive role in the regulation of extracellular peroxidases.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI08993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3I5"/>
    <dbReference type="STRING" id="1330021.A0A367L3I5"/>
    <dbReference type="OrthoDB" id="6718656at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.260.10:FF:000001">
        <property type="entry name" value="APSES transcription factor (MbpA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000365">
        <property type="entry name" value="Start control protein cdc10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF3">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0183">Conidiation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0749">Sporulation</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="10">
        <location>
            <begin position="34"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="435"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="8">
        <location>
            <begin position="579"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="197"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="735"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="229"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="248"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="739"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI08993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="868" mass="95323" checksum="C5F1E74BF423E449" modified="2018-11-07" version="1">MPVSSQPASQAFSQPRHAASFHHDHHAAAEGPKIYSASYSGVDVYEMEVNSIVVMRRRQDSWLNATQILKVAGVDKGKRTKILEKEIQTGEHEKVQGGYGKYQGTWIKFERGVEVCRQYGVEELLRPLLTYDMGQDGGVPGRGDLNTPTKEQAMAAQRKRLYNLGVDARPNHGLAGTFFKNISSTASHAVAAISKARFDSQGPRGRSGSARVPSFSRQPSMANADEFPANSQQSFTSDYSQQGEHAYSSQQQQQQQQQQQQQQQQQQSQQSQPSQQPSQQQPPQQQQQQHQHQHQQQQQQQQQQQQSSQPQQAAAAAAENEPPRKRQRVAVTPADSFGNYSNQNADLYATAFPGSPTEPNESFIETQATAASDRAAGDDARDSLAPMPYVHTAEIEAKRSMLMGLFLESDASDASKHEMLRSLSPAELDMPIDQQSHTVLHWAATLARMSLLRALIAAGASPYRVNTSGETPLMRACLVTNSMDHGSFPDLLEVLGGTIEARDHKGRTVLHHITVTSAVKGRNAASKYYLESLLEWVVRQGSVPNSQSSQANGNSQLEAPKKMGIARFMSEIVNAQDSSGDTALNIVARIGNRSIISQLIEVGADPWIANRVGLRPVDFNIGIDLAGELVHRTGEAVVEPNGPPTSAHRTRESSDGIVSSVTHLLNETGSAFQQDMRAKQASLDALHVTLRASLGQLSDARRNVDHLKTKAKKQQLSRQRVANLAHAREDEQMRLMKEQQSMSSQPNASSSWETELSAMLEAAEESSTTGPRGFNNESILPSSAVLKARIRAIEGRRDVTRKMVQALKGRSRELEVKYRRVVSLCTGVAEDEVDAVIDGLLKAVESEREELDVGRVKRFLSGVAAVVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3K8</accession>
    <name>A0A367L3K8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI09010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3K8"/>
    <dbReference type="OrthoDB" id="3340520at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010775">
        <property type="entry name" value="DUF1365"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33973">
        <property type="entry name" value="OS07G0153300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33973:SF4">
        <property type="entry name" value="OS07G0153300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07103">
        <property type="entry name" value="DUF1365"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="973"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="981"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1025"/>
            <end position="1034"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1042" mass="116557" checksum="CA6647C6A5D1DEB3" modified="2018-11-07" version="1">MAKRKLFHPKRLPPEFWDGLSKTFFTRNALRELDRRNAQRQEELERIQKQKQTSKAPRRSRRLRTREKTVPTVHQVLAQFSPSSLKGLKKSATHGGPDLTELRGYSMPPSSDNLQSLEDGKRKQKNSETTSSPSTGPFDLNFEQHLVDNSIYPHKHRYPAGHRPPRPANLDEIRFALAQPRLMDSPLETSDKKYKEFYQTDAAARTKSRVITAVLPMLEGGFSGYKDCVGRAKPFVNLHHLTDGTLLPANPDIHYGARPELLAGKIRQTLSSQIVPTQSDGPVASNYFVVARGPRGSAAIAQRQLCYDMALGERGQIALLSHGQPQLYYNHCAHTLGFTYQSGAVRMYAMHALEPLTDTSAPEYIMTLVDTYTMSGNARTFREGIRAFRNAKDWAQEQRDMIIAHANQQHARMHPLTPAAEESVVEEEMWSVKNMSSVGMDDDGALQLNSTTYLSVHLTHFRPPLQTMDDRPGQAGSYLVDDNLLSIAALSVAVLCGIFPTNWVDLLFVFLAFLCLGPTAGPYSSTSLIIKSLLPASLVPVLLYALYSAAAPSSGSADDPAWTGPGRPYLIPCRTTHRRLFPEKHSFSYSYLVVGVPVGFAGNIKGIVSAGLPRWRRRAWFDVDAADYLQRGFGEVGMRGKLDDFLRSQNVDPSDYPHAYLVTAARFLGYHFNPVSFWYLYSADKVLAAMVVEVNNTFGERRPYLVLRDLEADEQVSRIEASWPKDFHVSPFNSRKGTWSVLANDPLGAGMEGFGRLDVTIRLRSSKGHAKIVARLFSEGECVDPSRMSAVQRAAFVASWFWVGFVTLPRIVREAAALYFARGLRVWYRPEPLRDSLGRLADGVETDLERVFRRYLQFLVGESSCLSVTYEPSGIADVAAQVYTSSAGAERLEIRVLTPVFYSRFVQYDDGLEAMLCEMTESGTVWVDKPRLLPALFPSREERSGQQSWSRTGFKDGACFTLIKKLRRRPVPPAVSTLPTMEEKSNFRYNGRPEGDDMTKAGQCAARQTDSRHAAADENPSPDADNEHGTDIKVKPWVASYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3M2</accession>
    <name>A0A367L3M2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_4937</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI09033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367L3M2"/>
    <dbReference type="OrthoDB" id="7771656at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008313">
        <property type="entry name" value="GH125"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 157 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31047:SF0">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 157 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06824">
        <property type="entry name" value="Glyco_hydro_125"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01149">
        <property type="entry name" value="DUF1237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="2">
        <location>
            <begin position="1092"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1027"/>
            <end position="1063"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI09033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1503" mass="166914" checksum="83BCFC3A0E27CA11" modified="2018-11-07" version="1">MNSDFKSHVVSRLTLDRRKQHIDIPNRYQAQFISRSSGRPHNSSIRIIQDVHKMAELATRLDTHPPHAFLSARPIQNFDELRRDLESSMLRLRADPQYRHARAWIMLIDFQEDDSYIIEPFRRQLLDMFKYEYNWEIARYSIGGALRISTIEQEVADAICNFSSESIVPGGFVCFYISGRVLRTQQGGCTICGHNSMILNAESSGLSWDSLMESIRQTFGEGNRRLVILDSCTPATAYLEPRGFEMISASYWETAGGVPPPCMFLQAVVEAVRSNGFLTAIQLVSLLYHTDAVRSGKAMPVYKNNSWFFRQSSAMIHGMQPGAIMERAQGGAHSFTRPLVFVLVKVHVGAIHSCREFVVKMPLELWLGLVDKPGYMFTRCCLRHPSVAPLLTSNLGLLSRRLQFRLSTTCRLASGCRFEGPNAVDDFERTTASERLPSTLIIMLRLLLAAYLLGFSFRDRRVDAANSIDGQPPNKLAAACPNYATYASVPHPPLSTGKLALPFQRPDPQCRTFSSQEIERVIKEVTSKMKDPDLARLFENAFPSTTDTTVKFHTTGKDNGLVRTDGFHYARDEGAWEGPQSFITTGDIVAEWLRDSTNQLRPYLSLAKKDPAIFDLVLGAINTQSEYVIESPYCNAFQPPPISKLPVSSNGQDDTVHPVYEPSAVFECKYELDSLAHFLALANDFYHHTASTKFANQRWLLAIETVLDVLTKQSRPTFDPETGAYVRNDYTFQRTTNVGTETLGLQGVGNPLNGGTGLVRSAFRPSDDVTILGFFIPANAMISVELGRTSKILQAVGKASLAKTVQKWSEQIRAGVLEHGVVKHKKYGKVFAYEVDGYGSSILMDDANLPSLLALPIMGFCDAKDIVYQNTRKMILDRHGNPYFLSGKEFQGIGGPHIGLRNAWPMSVLMQAQTSDNDDEIKQCLDLVLKSSRLGLVHESVDVDHVRQYTRSWFAWANGVFAVTILDLAKRKPHLIFGPGAAPYVMMSLIYARNRCDDLPWYTGRVTWHEASKEGLAFPAYLVGRDETSKQTTVQPEEASDSDTLPRPPSTDRAYDVSSTATDQSAPRLALALRPAGESAISRLPARTGGPGLYGPDRGYQPLREALASWLGRQFGVEPEAERICITGGASQSLACILQSFTDPTLTRAVWIVEPCYHLACGIFEDAGFGARLRAAPGDGEGVDVDGLERRMTEMDNEVMPQLKVRQPLPALSLALCVDGNKPLKVPGPTRKSYKHVIYCVATCSNPSGITMSLRRRESLIRLARAHDALIISDDVYDFLTWPLQGDARPGAPSLPRLCDIDLASSDSLFGNAVSNGSFSKMVGPGMRTGWVEGSTAFVRGLGDTASTLSGGAPSQFCAAVLADLVMNGQLEMHIEDQLRPSLQRRHRIITDAVREHLSPLGITTRDDEDWYGGYFVWLSATTTTPLPPPRLIAEAAMRDANLVIGPGTMFEVRGDDRRTRFEAEIRLCFALGLLLKRMREDKKYYDDLRATFSKGANLDEYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L455</accession>
    <name>A0A367L455_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_1444</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L455"/>
    <dbReference type="STRING" id="1330021.A0A367L455"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050667">
        <property type="entry name" value="PPR-containing_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47939">
        <property type="entry name" value="MEMBRANE-ASSOCIATED SALT-INDUCIBLE PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47939:SF13">
        <property type="entry name" value="OS03G0201400 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="2">
        <location>
            <begin position="699"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="615"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="621"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI09204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="773" mass="87912" checksum="737CF69F769061D5" modified="2018-11-07" version="1">MAAAHLCRVSAALLSPSRAATSRLSRRTGRRPLSATAEPSEETDAMENLDRYIRQERRIDTASLMNSWKKRQSPVRMKNIPRERLPEMRVLRSLYLQWGFVRHHEKSGKKDYKAWKIQLNRVLRDQGHYSTTWIQQGRFLFELDHVDAMREAWEAEELETRQRIWPDVMLSTLCIRPGKLIQVLDATLDLPAPGYAIHDLLLIIARTFKIVTRATVAQKTAQADEMLGLIIRVFEDLPAGHVPFCQRTFGMLARELPCQQTSELYKLLVKKGCKMHEYTLLQFARKFASEVAHKPKSLDIMLELAERGTDLNKMPMTGVVTLLLHCKEPHRDGPTNRPASPFSPQEALGCLVEAGLAPNVIHVTALLDSLGQQGEVDESIRLALLFSDCGIQLDKKAWVTVVRSAKHSLDVDKFVQSLEVANKAMAPQRDLLNYGLHSVMYFANLESRETARPPPWTVPLFEPMLELYASRFSLVPLQRWFPEPLPLVLAGPPPGRASTSGHVREWRFRKGILPVVEGLFYKGITASSPQLQPDTTTVATMMRAFIRTVKSPMRLMSYFFFFRAQLERRTSAARCLLHDKGSLVHDAFIMAMTERDGLLSPALELFGEMIRENLPTVSGSSEEEQDEEQEDGEWQPEEEEKKKKKKKKKKTEKEKRVPMHPSPSTMTLALILRGLLGRGDRKTAEEIIQVLKELGVDLNLVGWNTLLKGYASMQFMHDTVATLQNLEAAGYRPDVFTFDAFARLHRQQEAIAHMQAIIDRHRSQQQGFGGGWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4R9</accession>
    <name>A0A367L4R9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="4">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_3758</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the TOP6A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="4"/>
    <dbReference type="EMBL" id="LKCN02000015">
        <property type="protein sequence ID" value="RCI09419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4R9"/>
    <dbReference type="STRING" id="1330021.A0A367L4R9"/>
    <dbReference type="OrthoDB" id="5377392at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000706">
        <property type="term" value="P:meiotic DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00223">
        <property type="entry name" value="TOPRIM_TopoIIB_SPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002815">
        <property type="entry name" value="Spo11/TopoVI_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013049">
        <property type="entry name" value="Spo11/TopoVI_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036078">
        <property type="entry name" value="Spo11/TopoVI_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034136">
        <property type="entry name" value="TOPRIM_Topo6A/Spo11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848:SF0">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21180">
        <property type="entry name" value="TOP6A-Spo11_Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04406">
        <property type="entry name" value="TP6A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01550">
        <property type="entry name" value="TOP6AFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56726">
        <property type="entry name" value="DNA topoisomerase IV, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52041">
        <property type="entry name" value="TOPO_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Spo11/DNA topoisomerase VI subunit A N-terminal" evidence="12">
        <location>
            <begin position="101"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Topoisomerase 6 subunit A/Spo11 TOPRIM" evidence="13">
        <location>
            <begin position="232"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="488"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="528"/>
            <end position="560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF21180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI09419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="609" mass="67054" checksum="100803235A768DA1" modified="2018-11-07" version="1">MSPNPSSPSRRDWSSSSLASPGALISRIESLLEPMVHALSRGEPMSIELLSHRSLRQLDGQARRRLISFPGNSLAEAQKFSTRPTSLHLGLHAPYKTSHILARVLFILQLSHDALVSGDVLTKRPVSTCSLYQHLFDKQRVVDDLVDDIAVTLDTHRDSLNIVASAKGLLSGRLIIQLRDGSTIDASSGDAATFRSLVSSRYWETSAAGPGLLITVFFFFQSACYSNQLTNLKAKGYPDLVTRSFLHRLHERHTQVPILVVTDLDHDGLNIFRCYRFGADGDHNLGIHWLGINTRHVQEVAAKMPASKLHQRSESLKTSISSTECRDGISLLSTRDRRMAVHMLARIAVRCPEGDAEAENLKLETQTMLMMNVKAEMQWLDDAGDMTKWLDDELPTLEQTHLNFHAPQRPYPASCFLSSACLSISNPSLPSNHIRSMVSPQLTDDEIDDIMYFSRAGETDELHETLSALAQREKVSPAEILEAVKDDAGSTPLHMATGNGHLETTRSIINLVNSSPSKQTFLDHGNEHGNTSLHWAALGGHLAIVELLLSNGASAACVNEGGCLAFDMALRNDRQQVVDFFLADDATTGIEALALEEMKQKKKASESSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4S6</accession>
    <name>A0A367L4S6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_1526</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4S6"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI09212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="70" mass="8029" checksum="20D632159F4FA536" modified="2018-11-07" version="1" fragment="single">YGYDTWHHWLLAGGFSRGILFKLYDAVTSCCDNGRSTIESFYWYIGNMSSLCRIFMPPMHGPLTSRSLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L546</accession>
    <name>A0A367L546_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_4109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L546"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI09544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="71" mass="7450" checksum="75F605495C581A0B" modified="2018-11-07" version="1">MRLSLGKQLDELWQLLAETHSCTGSVPGLGANGGNTLRGGSKYGTYLGTHHTIITSFGLPLCVQINTGGYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5B3</accession>
    <name>A0A367L5B3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3688</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000015">
        <property type="protein sequence ID" value="RCI09412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5B3"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="237" mass="26564" checksum="6E1F490C4E29DA78" modified="2018-11-07" version="1">MASRDSNGNIHILPLSSAPDSSSGSVPAQDDVSYVQDLHQCLCLARTPLLPNDIDKDSRCFMPTYDENRKDEQDLSKKASSHNLLRVFVAQLPDLGDELKQWHCPFDLGLGVHLKRSTRRETGPSHGIAPGRLLTARYQEPMCGVCATTAQRTLSLRSVITLLVRMIGNAGFSMAEIQFHHRHLEENWISRDQLGHKKNEEESQNHRPHFGKGHERCLLVRVFGILKRSSSISGLIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5M3</accession>
    <name>A0A367L5M3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_4071</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5M3"/>
    <dbReference type="STRING" id="1330021.A0A367L5M3"/>
    <dbReference type="OrthoDB" id="9439903at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000756">
        <property type="entry name" value="C2H2 transcription factor RfeC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF12">
        <property type="entry name" value="RFEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="221"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="338"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="75"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="193"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="371"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI09736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="431" mass="45944" checksum="0EE6AB9F3AC3B119" modified="2018-11-07" version="1">MDGSQYPSNGINTTSTSQTYPSPTALSPNHLQSASPLPQTLPPLQPPATTNNMQPMYGSNPHTPRTPGTPNTPNSASNSLPSYQNTSQPASRPSVYSMAQNPYPPHQAYNTSGAMMPQSTTAASHPQPIAPAPAPGGRGPPVLRPMPPGGIMPPGVASPYGGNALLQPTSVLRDMEPTHVVGSQGRRGILPSAPGRPAAPAAGTGAAKSAVIPTKDADGKFPCPHCTKTYLHAKHLKRHLLRHTGDRPYMCVLCRDTFSRSDILKRHFQKCSIRRGNPTGASHLSHPQAHVKKNAQAQKAAAINEGEMNHLNGMNNMPPDGAMVHPFGIVPVQDGMNNVNDQNHLSRSGSMNRVENGANQDGRQHMPPAMGNSQPYGGDVSNQMNNQQMQGYSMPQGQNMPMYGNQGQAQQPGLDWTSMFPPDANRNQARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5X8</accession>
    <name>A0A367L5X8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5X8"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="86" mass="9396" checksum="42DE793CEA4BE50D" modified="2018-11-07" version="1" fragment="single">GYSGYSARSTRYSDRYSDRRAHPINLGIRQPSHRSARCTNSGYSARSVVIAVITVIVTAIDALYLIRDTNKLSTNFSPPSSSSTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6F8</accession>
    <name>A0A367L6F8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_8695</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6F8"/>
    <dbReference type="STRING" id="1330021.A0A367L6F8"/>
    <dbReference type="OrthoDB" id="2261376at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000140">
        <property type="entry name" value="Putative MFS phospholipid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF10">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="396"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="435"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="42"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI10016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="506" mass="54818" checksum="F22416284EDFFBE3" modified="2018-11-07" version="1">MALRRLFPASPTPAPSPTASTPVADQQQQPHGNMSFLQKAMPVFACGAGLFSDGYINNVIGSVNTVLKIQYGDVYKSSPAASYVAGIALAGTVVGQLFFGFASDRWSRSNSLVASTVILIVFTALAAASYYRGDAVAMFSMLAAWRFFVGIGIGGEYPAGSVACAESSGELRSGTRNRWFILFTNSMIDWGFVFGAFVPYVVAAAARNGSYSTIWRTSLGIGVIFPVALLLMRMRLSEPNEFARESMRRETPYLLVFRYYWFRLFCVSLVWFLYDFSAYAFTIYASSILSSIYGDNAPLTTVFGWNTVITMFYLPGTMFGAFVSDWIGPKHTLILGVTLQAVVGYVMAAVYDRISRHVAAFAVVYGIFLTFGELGPGNNIGLLAAKTCATGVRGRYYGVAAAVGKIGAFVGAVVFPRIQAAGGEKGAVQSAQYPFWVASSFCILAAAVTMCIPNIGQDTITREDAEFRSYLEAKGWDTSLLGLAKDDSQVPSYTEEEQSAQQPMKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L770</accession>
    <name>A0A367L770_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">L249_8574</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L770"/>
    <dbReference type="STRING" id="1330021.A0A367L770"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06609">
        <property type="entry name" value="STKc_MST3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000411">
        <property type="entry name" value="Probable Ste20-like kinase Don3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000488">
        <property type="entry name" value="Related to severin kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="40"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="370"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="487"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="382"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="413"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="513"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RCI10276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="647" mass="70792" checksum="0478605F8D92AB4F" modified="2018-11-07" version="1" fragment="single">CLVPLPSLASLVVPVPLPAMADRNRDSDEANEALDPELLYSKDYCIGGGSFGKVYRGVDKRTGEAVAIKVIDIESADDEVEDIIQEIAILSELQSPYVTKYYGSYAKGAELWIVMEFCAGGSCADLVKPGPIGEDYIAIIVRELLLGLDYLHSDKKLHRDVKAANVLLSSSGQVKLADFGVSGQLSATMTKKNTFVGTPFWMAPEVIKQSGYDHKADMWSLGITALELANGEPPYADIHPMKVLFLIPKNPAPRLEGNFTKAFKDFVELCLQRDPKERPTARDLLRHPFIRKAKKTSYLTELIERHTRWAVTQKPEDDEGWDAADAGAPTEREAIDEDMWDFGTVRLVGDRGGVFTRSGLAALDESATNVRATRSVDGSDDSTEKRGDVSPTKSRDAVFRPSDTVKVAGTPRQPSPQRRPVPTQPPAASPTRVPLPPSPMKAVAGTPTRSNHTPRPLPPDPSTRTPGYERELLQRDLSKLNLDLGSAATESARMPSTSYPRAPANIPPYRGPTSRSTSQQTTAQRSVSMTKPQSPGEPSSFPSPSSADASGELDALNDVIFPALEEALKRRQTRLHQAVKTGEAGQRAEAAHDKLRRLVFKLAHVCKEIDHYDKAEPVGMGRDVDSFLEGLLEEILVRVEPLDEEEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7E5</accession>
    <name>A0A367L7E5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_4369</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7E5"/>
    <dbReference type="STRING" id="1330021.A0A367L7E5"/>
    <dbReference type="OrthoDB" id="196547at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009968">
        <property type="term" value="P:negative regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04450">
        <property type="entry name" value="DEP_RGS7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08708">
        <property type="entry name" value="RGS_FLBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058855">
        <property type="entry name" value="RGS1/SST2-like_Fungal-DR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF192">
        <property type="entry name" value="DOUBLE HIT, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25889">
        <property type="entry name" value="WHD_Fungal_DR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01301">
        <property type="entry name" value="RGSPROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0734">Signal transduction inhibitor</keyword>
    <feature type="domain" description="DEP" evidence="4">
        <location>
            <begin position="429"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="550"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="106"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="522"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="43"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="106"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="522"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI10331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="718" mass="79115" checksum="ECF6ED06E6099447" modified="2018-11-07" version="1">MAAISNPLTTVAASKPPPPVTVRTELPKRKLSLSTPRHHHSSVTRSDPTTSTTNNNTAASARHTSNPSVGSASTSRSQRSSHHSSSLLNRAVAALDRTQKSAFASLSSSSSSSSSASSSSNNNNDPVIRPRQSVSGLSRLSLAPATPPCSEPSSPEKKTEFKVLSSSSPTSARPPPLLDDSLSVLDDSPPVGPSPETEPLRSPTPVVSRSPVLDSKMHQTSSRLLRMTDDDRPFTRDFKDLFATLVVSLLPLSAHRVRLSKVEYTFLSEDAINNLGSLKFSQSNRMPDPKDPSRIVTTTTTTTFSMAKDMARSICQRFLEARFIESADGKYQQVYNMKGSVWQLTPKGITVLDRFCSRNGIQQKQVAELSSINSAQLVILERDQMSDKLLNDTGTIEVIFRRFVGSDGRNLKPTATAADSDSLHDYRDGLTGVKMAAERKVNGRIHRDTFTGKATTDWLMDCSTIVDRRETVEIATLFVEYGLIEAVTPDKVFMQQNTGYNLFQPTKHAIYQLSQRGKDLISGNGSRGRASGSEGGSQRNGICRDSNTQRLDKILNDPALRLLFRENLRETHCEENLSFYQDVTEFVRGCKAAIRQAQKSPTATSMDSIKEIMAQAYGIYNAFLAPGSPCELNIDHQLRNNLATRMTKAVGQDNSMIDTLQEVTTLFEDAQNAVFKLMASDSVPKFLRNAKYEQQLRIHDLDVNGRMPERSQSRSTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7J7</accession>
    <name>A0A367L7J7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_4431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7J7"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI10390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="55" mass="6068" checksum="4A99CA60927E3E0F" modified="2018-11-07" version="1" fragment="single">MHNHMSLRGMRPNLPPADLCATPTRLSPAQLLFSVHFLSHTLNMAKTVDEDSPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7Q9</accession>
    <name>A0A367L7Q9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7Q9"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="316" mass="35890" checksum="5CC253237BE8D55B" modified="2018-11-07" version="1" fragment="single">LPSFSSLPLLSTAGPTTYSDDRNRVRNRVRIRIRISSRIRVQAGNSSYDSRYNNSRYNNRNNSSIRTYLRPYRTYAPYSRYLYIRRFLLLFLFWRSISRHSGHHSNRHSDRRAVPIAVIAPDLDGRTKVRSSEIMPNTEKITFAKLSGGDNYTHWALRMDSLLIREKLQGALGSETHNKSEEAGHSARIDSLQRSSQRSARCTYSGHSTRLISAQGSRHIDRRAVLIAVIALDQSDRRAVPIAVIAPDLDGRTKLQLHHFFNTITSPAFNSSSILTKPPSRSRDVGPAVAGLRPLYVIEARLRPYGPYGPYKGRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L830</accession>
    <name>A0A367L830_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4219 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_4244</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L830"/>
    <dbReference type="OrthoDB" id="3599317at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI10571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="239" mass="27409" checksum="CDE3DB4BDC2FE80E" modified="2018-11-07" version="1" fragment="single">QWGYSGHSARIDSLQRSSQRSARCTYSGHSTRLISAQGSRYIDRRAVLIARSTRCTNSGHSARPRWSYQSQIVRLIHDVKVFLQITYLLRRRFSHLLPVYYQLQLHHFFNTITSPAFNSSLILTKPLSRDSSSSSLSQIMPNTEKITFAKLSGGDNYTYWALRMDSLLIREKLQGALGSKTHNKSEEALALIRLQLEDGPLTQIMHIKTASEAWNRLKELYNPVSFTSNFLLTKELLEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8M8</accession>
    <name>A0A367L8M8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8M8"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="109" mass="12292" checksum="34AAFCADF5A71418" modified="2018-11-07" version="1" fragment="single">PKPIFKTDWLLAINNTCDSPTLTLHPYAQLHLIKAKLTPFSFLTISMPILPANLPTYPGTYLHHPELTQRSIPTSYLPISKKTRYPETPFPLPPSPSSHPLSTPDHPTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8N8</accession>
    <name>A0A367L8N8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5285</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8N8"/>
    <dbReference type="STRING" id="1330021.A0A367L8N8"/>
    <dbReference type="OrthoDB" id="4509994at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI10781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="97" mass="11120" checksum="E5F9600A4FC21FCF" modified="2018-11-07" version="1" fragment="single">KIRTDKATFRDKEDRIGFLFRSLEGKARKTLETYLLTKTKDNSLSYKDFYGYVKDSAVKRLNAELVLPNDLPALAKYSLSILLPKTPLLNRQIDPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L910</accession>
    <name>A0A367L910_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">intramembrane prenyl-peptidase Rce1</fullName>
            <ecNumber evidence="10">3.4.26.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_5398</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic sidechains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.26.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase U48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.26.1" evidence="10"/>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L910"/>
    <dbReference type="STRING" id="1330021.A0A367L910"/>
    <dbReference type="OrthoDB" id="271604at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039731">
        <property type="entry name" value="Rce1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1/LyrA-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046:SF0">
        <property type="entry name" value="CAAX PRENYL PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13046">
        <property type="entry name" value="PROTEASE U48 CAAX PRENYL PROTEASE RCE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 2/Lysostaphin resistance protein A-like" evidence="12">
        <location>
            <begin position="138"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI10911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="300" mass="34019" checksum="DA8EA67E2C65CF51" modified="2018-11-07" version="1" fragment="single">MPNELLLYCGIYVLPLHCLSSTSLLPSRSRDDPRLIRARVRAVSLSTVACSLITYFILRRASLTTGTIPHNGSVSSTTISRCLHFMGFWPPGLLETFQASLLTALLFAGPIYERLLVDGLWRQWLQLIPLKLLWEDWPTWRNIIAGPITEECLFRSAATPLLLHTNAHLTNIIFLSPLIFGFAHLHHFYEFRISHPRTPLVSAIARSAIQLSYTSIFGIYATFIFLRTGSLLAVIFVHMICNSLGLPRLWGAVEPYWLIRGRSNHSKWTALYYFLLAGGFLLWSLNLFTLTLSSRALVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L934</accession>
    <name>A0A367L934_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_5166</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367L934"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050889">
        <property type="entry name" value="Dendritic_Spine_Reg/Scaffold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031348">
        <property type="entry name" value="PigL_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166:SF48">
        <property type="entry name" value="PROTEIN VAPYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166">
        <property type="entry name" value="ROLLING PEBBLES, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17111">
        <property type="entry name" value="PigL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Azaphilone pigments biosynthesis cluster protein L N-terminal" evidence="4">
        <location>
            <begin position="2"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="6">
        <location>
            <begin position="199"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="5">
        <location>
            <begin position="493"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="969"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1002"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1040"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1077"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1115"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1185"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1218"/>
            <end position="1250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI10929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1293" mass="143338" checksum="F5D9B4B6345B77AD" modified="2018-11-07" version="1">MADPLSMAASLIAVAQISGSIVSLCYYYIHGFQGANKEITKLLGESQSLRSVVEQLIQLVDKHDAESDVHLRALRETLAHSGLSEFQSSLKDLEGRLQFPVSKWQRLGAKLLWPLRERDVIQALESIHRMKSVFEFGLLTDATGCVVEMRRDIKDLISRFERIHLMPNKQRLQVLLDWLQAPDPSVLHHKLFKKRVAETGRWLLETEDFQQWIKGESSSLWLYGIAGCGKSVLSSVVIEEIKSRQGSQGGNIALAYHHFDFSNDASSRTETMLRSLVSQLSAWKGEPPAALEKGAENYHPYDDAIPFLHYKGRENTRFGVGQPNTYDLVKILLGIGLEFGQVYLVLDALDECFDREELLRILPSILGGETGFRVFVTSRHMADIAAVLSSHAASSLEAVMEDVDRDIDTFVRDRLTNHPKLSKWRPQVRNEIQASLVSGAKGMFRWADCQINTLGKCFNLRELRKAIRKLPKSLSDTYQQALLKVDENHWEYAIRTLMWLAVSPKPLRIEEAVDILAVDFEESEEWPVFSEDLRVCDAMEVPEVCGSLVSTMTSYIQEPDGSLAKSTELRLAHYTVKEYLLSDDFFSQFPRPMLFSNVSDSYAVAAKTSLAYISSLDDTLTQLSDRPLSRHAAEFWLYYNDLSPKDSRISHMIIKLLGDSNGTEPYRNWCRLFDPTRPWLPPNLERQSFPSPLYYTCSQGLLSETQMLLQNGASPNATGEFYGTCLQAAAFNGHVEIVRCLLLAGADPAREGGVYFCPIIAAAASGVVGVVECLLEYGADPNKLKSHPPDTFALMEAVRRNHVDVVEALLNGGANPDFTFYKAPVDHNCMDAALSRGFKDCAALILPRMSKWAATESLEMAFWTNRSRDTLRHFGDFIPDEVLAYAATSGYEDVVVELLDQGAKPYMCDVLRWLTWATIGYDASNMVTDVDHSIDLKNGYALIGAARGGFVDTVRLLLARGDDVNAACKTVTALTMAAYEGHREVVQVLLDHGASLREGIRYYGSPAHAAVLGDHADIIELLLAEGVDIETTAHCGKGMEECTLLQLAASSSNADIVDWLLDHGADPNAGAEDLDKHGVTALSRACKNDRSVDLVTLLIKAGAKVKAKSRFPDKMEEPPLHTAVRYGSVETVRALAEHGADVNEQCNDGWTALHKAAKRRKQEAADITEALLFELGGDWTLPLANGSLPIHMAASHDNTPCLEPLVRAGSDVNARNHAGRTPLHWAADNGALTAVEWLLDHGAASHYEEHGTAMTALDYAELRLREASYFDKKNTEAVRDALARHASQASKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LA62</accession>
    <name>A0A367LA62_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Ubiquitin-conjugating enzyme E2-16 kDa</fullName>
            <ecNumber evidence="18">1.3.8.6</ecNumber>
            <ecNumber evidence="4">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">E2 ubiquitin-conjugating enzyme 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Ubiquitin carrier protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Ubiquitin-protein ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">L249_7599</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26 27">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>glutaryl-CoA + oxidized [electron-transfer flavoprotein] + 2 H(+) = (2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13389"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57332"/>
            <dbReference type="ChEBI" id="CHEBI:57378"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.3.8.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 23">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="16">Amino-acid metabolism; lysine degradation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="17">Amino-acid metabolism; tryptophan metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 23">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.8.6" evidence="18"/>
    <dbReference type="EC" id="2.3.2.23" evidence="4"/>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LA62"/>
    <dbReference type="STRING" id="1330021.A0A367LA62"/>
    <dbReference type="OrthoDB" id="435240at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004361">
        <property type="term" value="F:glutaryl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046949">
        <property type="term" value="P:fatty-acyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01151">
        <property type="entry name" value="GCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23792">
        <property type="entry name" value="UBCc_UBE2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000003">
        <property type="entry name" value="glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000006">
        <property type="entry name" value="Glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000008">
        <property type="entry name" value="Glutaryl-CoA dehydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000010">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2-16 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052033">
        <property type="entry name" value="Glutaryl-CoA_DH_mitochondrial"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42807">
        <property type="entry name" value="GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42807:SF1">
        <property type="entry name" value="GLUTARYL-COA DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 23" id="KW-0274">FAD</keyword>
    <keyword evidence="5 23" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 23" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="25">
        <location>
            <begin position="524"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="455"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="455"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="482"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="24">
        <location>
            <begin position="501"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="22">
        <location>
            <position position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00037899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00037927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00039033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00074661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00077197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="RCI11311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="670" mass="73425" checksum="5339EAE711ADC0E1" modified="2018-11-07" version="1">MFTRPVLRNSSARLTRQLWRRPAAARVGFASSAPPFDWEDALNSRNLLTEEEIAVAETAERYCQECLAPRVLQAYRDEHYDASMLAEMGELGLLGAGISGYGCADVSSVAGGLITRAVERVDSGYRSGMSVQSSLVMGGIDQFGSVEQKERFLPDMARGRLLGAFGLTEPNHGSDPASMESTARPHPSRTGYYALSGAKTWITNSPVADVLMVWAKMHDTGRIRGFLVERGLCPAGTLETPAIKHKTGLRASVTGMILMDDCPVPEANMLPEVEGLRGPFSCLNKARYGIAMGVMGALQDCIARARTYALERKQFGGNPLARYQLVQKKLADAATEAAYGTLAAIQVGRLRDEGKATPEMISMVKRQNCDAALRNARALQEIFGGNAVSDEYAVGRHVANLYVAQTYEGQSDIHSLILGRAMTGVQAFETGRGFRVRPASSALILYRASRKSANSSSSLNTRSLPPKKKKYTSTPDVIFPSYPSTARQPRIAQRSNTQPPTHKKKQTGKKRTHLSSTTFEAVVMALKRINKELTDLGRDPPSSCSAGPVGDDLFHWQATIMGPTDSPYTGGVFFLSIHFPTDYPFKPPKVNFTTRIYHPNINSNGSICLDILRDQWSPALTISKVLLSICSMLTDPNPDDPLVPEIAHVYKTDRNRYETTAKEWTRKYAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAK6</accession>
    <name>A0A367LAK6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7472</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAK6"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI11443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="246" mass="25980" checksum="BFF2AD4A07120CA5" modified="2018-11-07" version="1">MRIRFHVIDGSLVEVFDIAQIQRATAVLIPLKLGYGRFRRLWSVESNHAGTTRPAARLVLDFSLLDLANGGEEFDQVIIACRPRELDSRHQSHGLTTHQKLCELTLRTAGSGVVGKWVGRDRSSGCRVKAASWASSKPATTAERKAATAAAEATTTKAAAAAAAASTAVASTHAAAVSATRWESHAGTSVAVFSHLEQSSLPVVSIKLLDSVSGVIRAFEDDDARALRSAVGADMNIGTDDSSDAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAS7</accession>
    <name>A0A367LAS7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_7715</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAS7"/>
    <dbReference type="OrthoDB" id="361039at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1113"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1146"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="426"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="773"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1240"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="450"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="784"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="808"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="1252"/>
            <end position="1261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI11521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1267" mass="139936" checksum="22BC2B0799BFCB5A" modified="2018-11-07" version="1">MTVAPLSESDSGGGETKSHGSFDSSTRFVVDPAGERTYDETTVDVVTVPCPGADPLQSWSRDGLVGRYFGAPSMRDADAVPARHGAASGPSWVRQGIRREAPRARILLYAHPDLVAGITLADLADALLQDLHLLRSGGAAERPLIFIAHSIGGLVVKMALTKAARNARYESVLRECYGVAFFGTPHQGSSYFAMSGLAANIRSLLRLSAPLPASVTDSLRVGNDLLLRLDDDFKAVSNDMRIWTLYETIESRFAAPEPRSDDVYFTAPITSSKSAILGMHQESIFAVQSDHANMASFGRHNGRVLTLFLRQLAVLIARADLALRHAADDAAARWSLDLEHRVSVEVHGFFDDAPTSDDSTIRAWSTRLPLSDFLAKGPLTCLSERLNEVDDADAGPNEIETRQAAPERLGPPPMSVVRNALGIRARQPASSHPLPVDAEPVPKAASPRDASPATIRSSPPTRPSSLVRADLEQDMAVDRLSPPLRPRIGRAISRSFSDGFSSLEYREYLAMSPRSRSAFEDSLAAARDDTDNIETSPRLPDAVVTIRNVVARSRAVVKESPTTFVKPDVKTRRFVWVHVPFNNPTWVKSVLQTLESSYGKNLSALYGHDFWSIRHTRGRQPQHYAHFAQPGCYIPSARTSKSSSTRQFCSETDTLTGKAASPGSRTAAAADEAAYTCLFLPYLHFDSYRRLIRRRNLIRQRQRHGRARPVPESVAKSDLLELQVVWEFLGHDPPVNCRRTLDQFGHPSLRDTRSRDDDQMLYKLTKDRDLGALPEPAADIRSQGSSAGTAGASSDRAGSGASTTSGGWRERLLRRGGTEMVDDGPEEETVLDGKVLMVDQLWLWAIDSQTDTLVSFFPRRESDPIDGPEFQQADLRDSIFNDVNVDRTRQCENALDLAALAALHAVSVLLDRSSHPDLEVFRIFDEGISALTEKLTWLLKAFRADGFRDKTEKLTWLLKAFRADGFRDKVIDDDEDDHPVESIRARHRQEASQAEKENRDSTSALLELRDIEDELLMLCQLFEQQSKVVSAMHGAYLGPQLRDRTSNGRVFLTEALHRLRDHAQKAGDMLQRARATREDYDKLLQMVQRQAQVDEVRLSRLNADLAGAQSRSVTIFTTFTVIFLPLTFFTGLFGMNTRQWGGGGNLPLETIASVSLPSSFVLVAVALVIAYSSSARTLPRRLARRLLDWTLSVARGRSTHDEGGSVVAAAAVAADRRRRAPEREVSDFWARHRLERDRGYRIPQVNRKPAARGGGGSGASGTRGRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBW8</accession>
    <name>A0A367LBW8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_4198</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000009">
        <property type="protein sequence ID" value="RCI11917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBW8"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI11917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="34" mass="4006" checksum="0D14D0C55CA7AF3E" modified="2018-11-07" version="1" fragment="single">DKKLTNWEGDHVIEKKKRNHVMKVRKADANNSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LC03</accession>
    <name>A0A367LC03_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_4609</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000008">
        <property type="protein sequence ID" value="RCI11946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LC03"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI11946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="134" mass="15093" checksum="AC87E451B96F6AB5" modified="2018-11-07" version="1">MMMSNQGVDHVIEKKKTNHVMVVLSDEVEADNELEVGDLEEDFNVMDQPDDLTLVRPSRSGAMTAIVQRADRCDGCLVPRSIGCYDRYRYSAPIAMTIAVTSRFGRYDRYSPTVTQGVVAGLRPNWYNLFQVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LC40</accession>
    <name>A0A367LC40_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein S16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_0849</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI11990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LC40"/>
    <dbReference type="STRING" id="1330021.A0A367LC40"/>
    <dbReference type="OrthoDB" id="407221at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1320.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00385">
        <property type="entry name" value="Ribosomal_bS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000307">
        <property type="entry name" value="Ribosomal_bS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020592">
        <property type="entry name" value="Ribosomal_bS16_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023803">
        <property type="entry name" value="Ribosomal_bS16_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00002">
        <property type="entry name" value="S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12919:SF20">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS16M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00886">
        <property type="entry name" value="Ribosomal_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54565">
        <property type="entry name" value="Ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00732">
        <property type="entry name" value="RIBOSOMAL_S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI11990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="12949" checksum="2B69D830D1504752" modified="2018-11-07" version="1">MVVRIRLARFGRRNAPFYNIVVAHARTARNSRPLEVLGTYDPIPRPDPYGPSHKLHKDVKLDIPRAQYWVGVGAQPSDTVWRLLSYVGIVPPKRLGPQPAKQGATIRSDKVRISC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCR0</accession>
    <name>A0A367LCR0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DASH complex subunit SPC34</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Outer kinetochore protein SPC34</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">L249_0158</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex SPC34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCR0"/>
    <dbReference type="OrthoDB" id="10016597at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013966">
        <property type="entry name" value="Spc34"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08657">
        <property type="entry name" value="DASH_Spc34"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="198"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="214"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RCI12210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="250" mass="27658" checksum="25DA94261FEA7CBD" modified="2018-11-07" version="1">MSLLSAHLEQISYSCQGIDALRFPPPKIFTNALLSNHDITSLIRDTEAHERALFSVPAPSPPQDAPTSAVVVPPPDEAADANRRRRQTVFSVASGEVTAAPTGSASHPRRRTAVAAVLGGEMHEQLRADRKGELDVDVLLRGAEKLCGVYELPGARERIAALRSRFRAGTNTVAYYEAKVSDQAAQLAAMNKLWIDDVDGDKQPEDEIESWTEDDLRREEQEAREMEVKKKELQERLRAMDKDLGGLMNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCV5</accession>
    <name>A0A367LCV5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCV5"/>
    <dbReference type="STRING" id="1330021.A0A367LCV5"/>
    <dbReference type="OrthoDB" id="422736at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22997">
        <property type="entry name" value="GT_LH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36587">
        <property type="entry name" value="EXPRESSION SITE-ASSOCIATED GENE 3 (ESAG3)-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36587:SF2">
        <property type="entry name" value="EXPRESSION SITE-ASSOCIATED GENE 3 (ESAG3)-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="533" mass="59944" checksum="E9CEE001614B68E6" modified="2018-11-07" version="1">MASAPFLRRALLPTACAIFIALMLLFVPRSSLRSTRFSSDSRLNWSLIGLRPAPRTSRLHYLVPASQPNLQLCYNLVSSIVNRYPVPMLLGWNGVGELDAAQTHLAKLRAMKRYLHSLPEQEDDDLAVIVDGYDIIHQLPAEIVVERYFDVANRADGQLADRLNMSVADARNGNLRQTLFWGPDKICFPFDPRAPRCWAAPPSPLGVNAFGPKTGNGEFEFNDPRWLNSGTVIGPVHDLRRLIDETMDEISATYDPHYDLRESDQYYVSNVWARQEYWRSKRRAVGGDVSGGPQDRVLPEKRSEKHETELHVAIDYESHIFQTKAGYEPFLRRLAFSDGDGNATTVNDDVLHLGDQFKPYPILMPVSVRKALTRLYDDLPDVRRGVSAGEWIRAISLGVNLVTKHIYAVWHCTGLKDSFDEEYRLQWWYPYTMSLLKAAVKSSQAGQLISADAVDGRRWAPKKTFPSSLPSGDVLYGGAWSDADGGRFVAWSELCAAHEEVLFRGERESIVASPPTPVVAQLKKRRSPSSSPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LD76</accession>
    <name>A0A367LD76_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_0404</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LD76"/>
    <dbReference type="STRING" id="1330021.A0A367LD76"/>
    <dbReference type="OrthoDB" id="3553547at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="197"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="494"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="155"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="505"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="549"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI12367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="568" mass="63869" checksum="17EAFFD90C55C3CD" modified="2018-11-07" version="1">MTNNSVSASSTTLSLSRPICSSESSSSSSSIEDPIAYRNARLFPPQFPAQSAPPPRSRTLATSRITTWNRDHSSDVSCGSSSQLQMLWQQLKQRRDKLGQTKRCMAKKRQELRCLRRQKDEADNALMSILRPMLVSQRGLLQTSAQTLDSRMTVMQDLRDDYRCLESEYEALELTMDEEEKELNRLETRFFTLLGAGHGRKTTSGRPTAGSDAGSEHSTSPSKHQKLPYELTGISAHKDVEDVHPLYSRLTSTMGDLENARDDYQELLYLADQYRHEPDLGTSTGKKAMADAQDFLAEFPAEEARLKTQVSTLEAQVDQLKAECEAKKVMRKHMSVGMAYALGPRDEKFQDIELDDVASILARRPQSLAHASFPELLSQPDHVLASPHPLTALQAFRAATRLPDHHPDKREWQRLTAKEYAIESLMRGDDQGAAAATGDLVSRWLLQQLRQSALAVSLLHSTFVSSRSLRIRDTWRWQRDVLYYWWRDDTVRPTRHRHRDRGGGDDGDDDDDDDGDDDDDDDDALSAVGSSNSSRLGTPLMTRAASDGVLDRRERRPRDSDGAVTTDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LD79</accession>
    <name>A0A367LD79_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GPR1/FUN34/yaaH family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_0043</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LD79"/>
    <dbReference type="STRING" id="1330021.A0A367LD79"/>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038013">
        <property type="entry name" value="AceTr_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF1">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI12375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="26629" checksum="22B5158642691F7E" modified="2018-11-07" version="1">MASTTGTLSPGEQHGYTAPKPHQSTVSQVPDPKPFRAANPGPLGLISFALTTFCLSIYLCGAGLPDSNPLGTVGPDQAIFGLAVFFGGAAQFIAGIMEFRVGNTFGTTVHCSYGAFWLAFAMFQVPSLGIREAYRGDERAFTVAMGIMLILWCFLTLLFVLAALRTNLAIVSVLGSLAFAFFFLSLGQFLTTSHPVAARRLIRAGGIFGALCALGAFYAGSSGLMTEDTTWVRFPLGEFRYRPRRQASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDP9</accession>
    <name>A0A367LDP9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_0839</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDP9"/>
    <dbReference type="STRING" id="1330021.A0A367LDP9"/>
    <dbReference type="OrthoDB" id="438545at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061459">
        <property type="term" value="F:L-arginine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005290">
        <property type="term" value="F:L-histidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015189">
        <property type="term" value="F:L-lysine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015194">
        <property type="term" value="F:L-serine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005302">
        <property type="term" value="F:L-tyrosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF678">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="159"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="261"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="396"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="496"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="11">
        <location>
            <begin position="35"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI12549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="518" mass="56005" checksum="97E3D919268F8B3F" modified="2018-11-07" version="1">MTTESTIPEAIHASGAHDMSRTRRRGGKDGGHGGQASTLSSIVNLLNTIVGAGTLAMPSVLSHMGIMLGVVLILWSGVTAAFGLYLQSRCSRYLDRGTSSFFALSQITYPNASVIFDLAIAVKCFGVAVSYMIIIGDLMPGVMLGFNDAVADIPYLVDRHFWVTAFMLLIIPLSFLRRLDSLKYTSLVALVSIGYLIVLVIYHFAADSHADPEDIRVIKWAGPVETLSALPVVVFAYTCHQNMFSIINEIKDNSPASMVEVVASSIGSAACVYVLVAITGYITFGNSIVGNIVSMYPTGVASTIGKAAIVLLVLFSIPLQIHPCRASLHAVLKWRPNRSSANAGRPGSPLLNASAVPRGDHGSGTPISDTRFALLTTVILTLAYMTALSVSSLDRVLAFVGSTGSTSISFILPGLFYYKISDPDSIHHQRLMKGDDDMEDEPSSDVEEAGGGILTQSTSSIRSFNSSQPRWRWRRKWRWDLEHLDHQLLRKLALSLAAYGIVVMSVCLVMNIFFAVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDW8</accession>
    <name>A0A367LDW8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ZZ-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_1027</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDW8"/>
    <dbReference type="STRING" id="1330021.A0A367LDW8"/>
    <dbReference type="OrthoDB" id="661148at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14947">
        <property type="entry name" value="NBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02249">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02340">
        <property type="entry name" value="ZZ_NBR1_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd02341">
        <property type="entry name" value="ZZ_ZZZ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032350">
        <property type="entry name" value="Nbr1_FW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041981">
        <property type="entry name" value="ZZZ3_ZZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20930">
        <property type="entry name" value="OVARIAN CARCINOMA ANTIGEN CA125-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20930:SF0">
        <property type="entry name" value="PROTEIN ILRUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16158">
        <property type="entry name" value="N_BRCA1_IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="6">
        <location>
            <begin position="418"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="ZZ-type" evidence="6">
        <location>
            <begin position="557"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="888"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="904"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="944"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI12610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="953" mass="105098" checksum="3128231DEF7FC278" modified="2018-11-07" version="1" fragment="single">DHSSSIHPRLRSSPRNHLPEGSWRPSDSRRLEYRSGAEAYLLASSVQRCASIRHRVTACQILLDILTVWVTSVHCRCRRLSMSTSLQTAGSDASVLVKILYDGTTRRAKLPLREMAPMTLEQHVRTFLQIPHDAKMSMERYSDSAAAYVVLDSNNTSIYKQLYRAAKAKSKLKLRITVLDTDDKPSPVPTVGPLDDAPGAAGPEAVVKSETLSPTVSLPTPSVMALPLRGSCPHGVPTIPTSAEADDKDHRASSGDWNSAELQNRLSQLEERLRASSMARNSEKVEDAVSPLTATSRLNAYHPATGCHFAVCCNSCERTIPDAHYHCSTCDDGDFDLCQVCVDQGITCYNNDHWMIKRAVKNGQLVNSTTETIASKPKEPKPREFKELAPYEPYRGRISVPRAVVEQPACAWPSATSTTMRTCNCCVQELPERDFLHCTVCEDFDLCQPCFAKDAHGHHPKHGFAPTVTGVQLPDHIKVRMSPGRNQMHHAICDGCDKFIAGIRHKCLDCPDWDYCSDCIHTANFVHANHRFVPVYEPLAIPQAWSAGQSLHHGICCDGPLCSISQAFPTYIRGVRYKCAVCHDLDFCANCEASPANTHNKTHPLIKFKTPVRHVSVTTTGEHHNGKRMPAMGDRNTTKTAATATSISDRISINTVQTVVDVKPLEVSSPAKSEAPVVKETPSELEVNLVQTMPQLSDRLAVEKDLRAVFVRDSVEDGTIMAPNHVFEQTWILRNEGTVAWPAGCSVKFVGGDYMGHVDSNHPACISELVSASESTVCYAPLAPGQEFSFTVLLRTPPRAGKVISYWRLTTGYGHKFGHRLWCEVNVRPATTEPKVQGSCVHIEDVREQAPHTGSPRSSRTMIFPKLAKESPRASLHEDSAAANEDEIAKVATEPAAPTKSDVEDGFDGCGEDESWDGSDDGFMTDEEYDILDASDEEFLEQQQQEKKKSLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDX2</accession>
    <name>A0A367LDX2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_0167</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDX2"/>
    <dbReference type="STRING" id="1330021.A0A367LDX2"/>
    <dbReference type="OrthoDB" id="4454541at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000295">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.7, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF16">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="440"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="52"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI12624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="519" mass="57143" checksum="0398A4312FEEFF8A" modified="2018-11-07" version="1">MASSGKLAVISHDEAAVDEERELQPQQQAEQGRIQLSEADDKRICRKTDGVILTILVWVYFLQILDKTVLAYGATYGLKVDTGLQGNQYSLVSAAGPIAQLLWQPMSSYLIVRVPHRTLMTGLVLGWGIAQSASAACHDFSGLMAARFFLGLFEAGCLPLFGIITSQWYRRAEQPLRIAAWYGTNGLATIFASVLSFGLGQIRSSVLRPWQIIFLFVGLMTVITAPFVFYRLDNDIPSARFLNEDEKLMAMERLRSNQSGTVSRAFEPGQAIEAAREPKTYLWIAMTLLLNVGASVTNTFGPIILDGLVSNHDFTSLLNIPFGALQFIFILLASFLSQKARLKGAVLVVFMMPVVAGLAVLLAVRRGAAASSQGALLTGYYLLAFIFGGNPLMVTWIIGNTAGTTKQSIVMALYNASSAAGNIIGPLLFNDKDAPAYKPGLRACLAIFVALVLVLLLQWTNLVMLNKKQETKRLRNGKSARLVDYSMQQRFEHVEIRTREDVSRSNLTDGENDEFIYIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEQ0</accession>
    <name>A0A367LEQ0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEQ0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="115" mass="12395" checksum="7B15450AAD33742A" modified="2018-11-07" version="1">MKSGGKVSDELSPRAKNADDGGLCCLAQIPYKRPAPACRPSPATILSQNHASANADARLLIRHSQGFLIERALVTTNRIITAEPNRPRPANTTFPIRYIEKTPSVSGSCCLAFYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LF94</accession>
    <name>A0A367LF94_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_0229</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LF94"/>
    <dbReference type="STRING" id="1330021.A0A367LF94"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF2">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3-PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="646"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="679"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="SAC" evidence="2">
        <location>
            <begin position="175"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI13093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="760" mass="86077" checksum="0FDE8E29324B5E1C" modified="2018-11-07" version="1">MATLFPDLVRTSSGPRQDLSIHLPAQYGPLLPRADIVPLREARPLPPRQPSMAPLAAAKLPYRDINLRVTSDAYVFVSPSSPDAPALLIDRPTGDLRTADAAQQAVKRTTRVSSVAGILGLIQLRLDKYVVVITKARPVGRLKGHLIYKLVAAELLPMRERQIHDRDEDTFISLMKAFLLRGPMYFSYSADLSNSFQRQALSDTSAPLWMRADDRFFFNKYLQSDLIEFRKSGSRSQPGPQSAVDPYILPCIFGMLEIRPTTFNKTSLTLVLISRRSRYRGGTRYFTRGVDEDGHVANYNETEQIVILNDSSNGLGGFAGSTDMQSGRFDPAQGRETHVMSYVQTRGSVPTYWAEINSLRYVPKLQVRSTEAALSAAQKHFDEQIRLYGDNYLINLVNQKGRECRVKESYEHMVQSLMTGPQEGHDADRLTDEKFTTIQPGAKRQAFDRLHYVYFDYHNETKGMRMHRAYALVEKLREALAAQGYFRGTDTPANVDGRIDVRGLQTSVMRVNCMDCLDRTNVVQSMFARHMLDRIFHDAGLIPRGATFRDTDPAFEVLFRNLWADNADVVSSSYAGTGAMKTDVTRTGQRTKMGSLQDARIGITRYYLNNFRDGPRQDAYDLFLGTYQPGTADVGTELVFVDSRPLLLQSIPYLLAFSVFIVLIGLFTRRDSDARPMTMRLFVLFWTAVAAWCFYFIWTHGMLYVNWPRLIPRPFAVDGYGEHYSQARKDAVIGPFVSRHQRGLSAARYLNAEEGKKRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFG0</accession>
    <name>A0A367LFG0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFG0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="172" mass="18722" checksum="BE50A06133AD88DA" modified="2018-11-07" version="1" fragment="single">MSVGDTLPSFWNSGSLVPMLLVYTTLDDVSPVGKTLEAQKHSRTEKVGSQNLRGAPSFVRRGAAGRRMCQRLRVFGLDYSHGGIGGKRQLGVMRVQCVFCCTSTVLSISVSSKTPLDYWLMQRSSLVMTPNGLVARRRYVASRPALPARNDRRPGHKPPFTDGVAGGGRDKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LG54</accession>
    <name>A0A367LG54_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_5588</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LG54"/>
    <dbReference type="STRING" id="1330021.A0A367LG54"/>
    <dbReference type="OrthoDB" id="5595695at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051781">
        <property type="entry name" value="Metallo-dep_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135:SF3">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016587716" description="Amidohydrolase-related domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydrolase-related" evidence="2">
        <location>
            <begin position="74"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI13400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="407" mass="43888" checksum="D19879F0CBEF761F" modified="2018-11-07" version="1">MRSHCTVLLLALSHFSQVLSLTITNVTVVDVNSGDLRPSQDIVVKDNKIESIDNTSKKNSKTDDDDVDGTGKFAIPGLSDMHVHAYFRNDPASFKVTDNITMPLFVANGVTTVRDLGSNLKAIKSARNLIKEHQLVGPRVFFTGPMLDGKDSPYEAAIKLETAEQARQAVKNLTDSGVDFIKVHLLLSRDVFDEVARACQDENVRFGGHVPDAIDAKYAVEKGMAFIEHMSRLDNADGNLTKTLVEKQIWQCPTLKLSPAGARMRLTKALFDAGTPMVAGTDSPAGRNLCPGVSLHDELEFMNKAGLSQLETLQTATKNAASFLGREDEMGTVEAGKLADMVLLEGNPLEDISNVRSISAVIADGQVFSGDELKAMLAGADRLVQCNKQGSVVARELLSAGPSCCSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGE3</accession>
    <name>A0A367LGE3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGE3"/>
    <dbReference type="STRING" id="1330021.A0A367LGE3"/>
    <dbReference type="OrthoDB" id="415358at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041667">
        <property type="entry name" value="Cupin_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461:SF99">
        <property type="entry name" value="BIFUNCTIONAL PEPTIDASE AND (3S)-LYSYL HYDROXYLASE JMJD7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12461">
        <property type="entry name" value="HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13621">
        <property type="entry name" value="Cupin_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="JmjC" evidence="1">
        <location>
            <begin position="114"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="327" mass="36786" checksum="F6F752091C7916F9" modified="2018-11-07" version="1">MITPIQSALEELISTYNELNPPFVEELDSEPSPLEFMRFVSRNSPFVVRGGASSWRATSKWNSAYLRHALAGQAINVAVTPKGNADSPTACPALNRTVLAKPHEELEPFDEFLAYTVQQETDPAFPSNSEVRYAQTQNDNLRDEYLALLPDAQKDIPFARIALQKPPDAVNLWIGNSRSSTATHKDNFENIFVQIVGRKHFNLLPPLCHACMNEKLLPPATYIRTDDGLSLRPDEHGEPVPFATWDPDEPTINPTPVSHLARPLRVTLEPGDMLYLPAMWYHKVTQSCPSDSEGFIIAINYWYDMEFSGMLYPLSTFIRAVTPKIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LH56</accession>
    <name>A0A367LH56_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LH56"/>
    <dbReference type="STRING" id="1330021.A0A367LH56"/>
    <dbReference type="OrthoDB" id="2555634at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018800">
        <property type="entry name" value="PRCC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13621">
        <property type="entry name" value="PROLINE-RICH PROTEIN PRCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13621:SF2">
        <property type="entry name" value="PROLINE-RICH PROTEIN PRCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10253">
        <property type="entry name" value="PRCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="353" mass="37680" checksum="7F39D3936D4EC830" modified="2018-11-07" version="1">MALVDYSESESSDSEKERPATRPALKKRVVDHRGKIIVNLPPPPSSSTTAQGSSSSSPPPAKRARTSGSGLFSGFNSLLPPPKKTTRSVALKTSTEPGFDRGADNGSSAAVDAQPPAETCASPPQPTPPSNGDKPPQTQEKAPQSESIGKPTMFKPLSVARSAHKKKTKTSPAAKAKETHSTPSSPAPTPKKQSLFSLHTEIEASTPKIEANSVEYSTAPLLDTASVSTPAAEPGADDGHPLPPHGQTHRLDTIANDLNLSAAARRELFGRNASINVAQPVINYNMDDEYQRNEQLRAAGEQQTHNPVRAIQGGKHNLRQLVQNVQSQRDALEDSFAQGKSNRKDASSRYGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHP5</accession>
    <name>A0A367LHP5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Membrane protein TMS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_8094</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TDE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHP5"/>
    <dbReference type="STRING" id="1330021.A0A367LHP5"/>
    <dbReference type="OrthoDB" id="5963193at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005016">
        <property type="entry name" value="TDE1/TMS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383">
        <property type="entry name" value="SERINE INCORPORATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10383:SF9">
        <property type="entry name" value="SERINE INCORPORATOR, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03348">
        <property type="entry name" value="Serinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="449"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI13919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="479" mass="52629" checksum="64BEA28B5F4E056E" modified="2018-11-07" version="1">MGAVLSLPLLAVPSIGSVMSFAATCCGAATCSMVCRACGKCGNSVATRIAYALILLVNSILAWVMLTPWAIEKLQHLTLDYVKINCPTGQCYGWLAVHRINFALGLMHLLLAGLLLGVKSSRGPRAAIQNGYWGPKLIAWMALIVMAFLIPDRFFMFWGNYVSLICAMLFLLLGLILLVDLAHNWAEYCLAQIENSDSKLWRSILIGSTLGMYLASIAMTVVQFVFFAGRNCSMNQAVISINLVLWIAISFVSVNPTVQEHNPRAGLAQAAMVAAYCTYLTMSAVSMEPDGDNRCNPLIRGQETRTTSVIIGAIVTMLTIAYTTTRAATQSLGLGSTDGAIRLPEDDDQHDLVVQQPSARREMRAEALRRAIDEGSLPADAELSDMESDGLEGSEQDDERSRTQYNYTIFHIIFFLATAWVSTLLTLKYEETKQDGDFATVGRTYAASWVKIVSAWICYGLYIWTLTAPIILPDRFDFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHU6</accession>
    <name>A0A367LHU6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHU6"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="133" mass="13484" checksum="B0568F3FC4EC917D" modified="2018-11-07" version="1" fragment="single">PGYACPSPSYARSSTACANSDKEPINDNDDNYKSGPVYMPEAALTPPKIEGGLGADRIGSAPRDYNGDGDSNVIEVPAKRQRLEVVVEEERVLVEEGVAAAGGGGEESPGGGDPAATLGLRGEGLDAPLSGVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHX4</accession>
    <name>A0A367LHX4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_8297</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI14028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHX4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="167" mass="19369" checksum="9EA812B96876A341" modified="2018-11-07" version="1" fragment="single">DEEDRIGFLFRSLEGKAYKTLETYLLTKTKDNSLSYEDFCSYVKDSIRTDKATFRDKEDRIGFLFCSLEGKARKTLETRLLTKTKDDSLSYEDFCGYVKDSAIKRLDAELVLPKRNYYSTMPLESLSSLTTSPPLLSTPSRSFCLRRLYLIGRSTWLFRLTRNVGTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHZ2</accession>
    <name>A0A367LHZ2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8092</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI14053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHZ2"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="107" mass="11911" checksum="FA97F3C4D0B50F37" modified="2018-11-07" version="1">MTGEIGTFEYRHMTPVVSFLPLSSSSSSPFKPFSRVESSRVEYVVVHTMDSSESFVLVSVKTGFFFFFFVIIIIFVSVSVSVVGIDTCLLCIPMPITIAILIQTFHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LI48</accession>
    <name>A0A367LI48_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_8255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI14095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LI48"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="82" mass="9322" checksum="039011FCCCCFD38E" modified="2018-11-07" version="1">MRFHSPFIRLFSSQSAICQAIFSLLFALDGPKVTMIVESGGPGRYVTYMDLMGYRGRTRLVENRRIQLMLIPSQPRTAACHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LI87</accession>
    <name>A0A367LI87_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_6052</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LI87"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="67" mass="7455" checksum="DC9928DA1B1AC252" modified="2018-11-07" version="1">MLTRRLIDPYIQKIRLPRQTSVPRLPDLPYVPSLPPPTLLCCSYLSSVTYGGLERHVTLLGPPAGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIB0</accession>
    <name>A0A367LIB0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIB0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="99" mass="10924" checksum="83D11510D84B9592" modified="2018-11-07" version="1" fragment="single">PKARHNALSHSGAIAVIAPDRLVTAIVTAIGALRYSDRRAVPIARSTRCTNSGHSARPRWSYQSQIVRLIHDVEVFLQTTYLPSQISKEGKYILTNGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIF0</accession>
    <name>A0A367LIF0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6019</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIF0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016611513" evidence="1">
        <location>
            <begin position="18"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="66" mass="7325" checksum="032D53571E4F4C47" modified="2018-11-07" version="1">MLAIFSALLALLPRSLDLRNPEDEVTALRISYKILLDILDILVNKGDLTTSSEAIAMLKVAQDIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIT8</accession>
    <name>A0A367LIT8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5943</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIT8"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="76" mass="8466" checksum="B0502B75B9C1CDB9" modified="2018-11-07" version="1">MPFIFTYFRVPQARPCLTRQRQKRNAAGDVVAESAAKTAESSPVVGGGVPPACLRLFQGHLHLLHFQHPVRTCLPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIX1</accession>
    <name>A0A367LIX1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Beta-coat protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L249_5954</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
            <orientation evidence="1 10">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasmic vesicle</location>
            <location evidence="10">COPI-coated vesicle membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIX1"/>
    <dbReference type="STRING" id="1330021.A0A367LIX1"/>
    <dbReference type="OrthoDB" id="10261439at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000260">
        <property type="entry name" value="Coatomer subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011710">
        <property type="entry name" value="Coatomer_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016460">
        <property type="entry name" value="COPB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029446">
        <property type="entry name" value="COPB1_appendage_platform_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635:SF0">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07718">
        <property type="entry name" value="Coatamer_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14806">
        <property type="entry name" value="Coatomer_b_Cpla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005727">
        <property type="entry name" value="Coatomer_beta_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="12">
        <location>
            <begin position="27"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer beta subunit C-terminal" evidence="13">
        <location>
            <begin position="678"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer beta subunit appendage platform" evidence="14">
        <location>
            <begin position="819"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="496"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCI14365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="956" mass="106208" checksum="C974646B515FBC4E" modified="2018-11-07" version="1">MSSFLENAYSLVHQDNAADVPTVSDLRLQLEKGSDEVKVDTMKHILTIMLNGDPMPTLLMHIIRFVMPSKHKPLKKLLYFYYEICPKLDGSGKLKQEMILVCNGIRNDLQHPNEYIRGNTLRFLCKLREPELIEPLLSSARACLEHRHAYVRKNAVFAVSSIYLHSPSLIPDAAELISTFLEGETDATCKRNAFAALASINHDAALLYLSSVFDGIPNAAELLQLVELEFIRKDAVQNSQNKARYLRLIFDLLEAGASTVVYEAASSLTALTNNPVAVKAAAVKFIELSIKEADNNVKLIVLDRVDQLRKKNEGILDDLTMEVLRVLSSTDIDVRRKALGIALDMVSSRNVEDVVLLLKKELSKTVDQEYEKNAEYRSLLIHSIHQCAIKFSEIAASVVELLMDFIADFNNASAVDVINFVKEVVEKFPNLRKTIVERLVTTLGEVRAGKVYRGIMWIIGEYSLEEVDIRDAWKRIRASLGEIPILASEQRLLEDHDTDKNDDQVNGSSKAAAPSGSRKVLADGTYATETALTSQSSAAARLEAVKAAQKPPLRQLILDGDYYLAAVLSSTLVKLVLRHSEVSADTARTNALRAEAMLIMISILRVGQSQFVKAPIDEDSVDRIMSCVRSLADFRERKGLETVWLDDTRKAFRAMVQVEEKKRAAKEAYEKAKTAAQVDDVVQIRQLSKRNVTSDLDGIEVDLERATGGESPTEDLSSKLSRVVQLTGFSDPVYAEAYVKVHQFDIVLDVLLVNQTTETLQNLSVEFATLGDLKVVERPTTQNLGAHDFHNVQCTIKVSSTDTGVIFGNVVYDGAHSTDTNVVILNDLHVDIMDYIQPATCTETQFRTMWTEFEWENKVNINSKARSLRAFLDQLKACTNMNCLTPEASLKGDCQFLSANLYARSVFGEDALANLSLEKEGEDGPITGFVRIRSRSQGLALSLGSLKGLNKIGTTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIX3</accession>
    <name>A0A367LIX3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5987</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIX3"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="170" mass="18856" checksum="1148D679E5DF0516" modified="2018-11-07" version="1">MGKKWVCLLKSVGKVESNEVFCGAVEEEEGGEKLVEMEIMMSNQGVDHVIEKKKTNHVMVGKPPSFIDKFLNNKDFNVMDQPDDLTLVRPSRSGAMTAISTARRSLYSAPIAVTAALCRDQSGAMTAIGTARRSLALWRALGLIGTICSKWPYRLISYPFKMKKYALYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJ71</accession>
    <name>A0A367LJ71_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_5918</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LJ71"/>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09817">
        <property type="entry name" value="linoleate_diol_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051820">
        <property type="entry name" value="FAD-binding_MO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034812">
        <property type="entry name" value="Ppo-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43872">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G02570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43872:SF1">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G02570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1362"/>
            <end position="1383"/>
        </location>
    </feature>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="6">
        <location>
            <begin position="1118"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="3">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI14312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1603" mass="178098" checksum="A34265B542056DC0" modified="2018-11-07" version="1">MATAEKFMADEAYADPRHHSSDPSKDPVKLVVDLWHNHACIREQASEAELVDLVQELRHVRKGAPLDDKKGTTELLIGILTSLPSTSEARAVLTSRLIDKLWAGLQHPPQTYVGGRAAFRAVDAPEPVAATDADEAVEFRVPDTDVLLRGPLPDEGLFQYRTPDGRGNNVLQPDVGKAGSPYARTVRATKRLHGVKPDPGILFDLLMARDDAHFSENPAGLSSMFFYHASIIIHDIFRSGGPDGNRSMTSSYLDLAPLYGSSMRDQLEIRTMKHGKLKPDTFHEKRLLGQPAGVSVLLVLYSRFHNHVCDVLLQINEDGRFTPACTPESSPQDRAVALAKQDHDLFNTARLIVGGLYVNISVHDYLRAITNTHRSASDWTLDPRVDTVAADGTPHAVGNQVSVEFNLLYRFHACISKKDERWMNDFFFKLFPGRDPDHLQAVSPSELHQALVRLLEKAPKDPSARDIGDIKRQGDGTFRNEDLVRVLGEAMDDPAGSFGARMIPKALRAVEILGINQARRWQVASLNEFRDFFGLKRHESFSDINSDPNIAAMLEKLYSDPDMVELYPGLMIEDVKPPRSTGCGICPTYSVGRAILTDAIALVRGDRFNTVDFTAGNLTNWGFREVMPDYETLGGSVLYRLIQRTLPGWFPYNSVAVMQPMYTKAANEEIARKLGTIGQFTMDGARQPPAAVVVSTRAAIKEVLGRSDRFAVPWLRAFHAMFPDGEKDLSWFMLAGDEARNRQNRVELTTVLDGLPDVRGALLGMIAREGARLIDKQKLGLPSGVDQLDIIRDVAIPLSAQMLADLFYLDLRSDDNPSGTLNATELYRHLLNIRIWGVENSDPAQAWDRRRRARESVHVIIKSTRRLVDEVAGASLAAMLSGLLSGRAHGARGGSLRACGHQLVTELLGMYDSPERVVDILWLAAFGGTGVAVTTFYEVMEYLLRPQNAPVWARVRDVARNGDDDALIGCVLEAQRLSSSQRNVRVATQKTEIEGKAVQPGDLVLMLLVGLTQFSPTTASRMLSWSKGEAGRNPNEVPEPGTFDPQREEGDAMCYSYGQHECLMKQLAPAYVAGMVRLAAGLEELRPAAGVRRVRVGGQMMFVNDCWSRLGSNVSNWDVVIIGGGLAGINFAYRLREAHPQLSFCILEARHEVGGTWSLFKYPGVRSDVDMYQYGFAWHVWRHDSPIGSGAQILDYIKEAAVGFDDRIRLNHRVEQMRWSTARRTWTLDVTVCPPSSSSSSSSSSSFTMTTRFVLLSTGHFDYEQPLAADIPGLDSFVGPVIHPQFWPDDFDYAGKRVVVIGSGVTAVNLVTTMAAQAKHVTMLQRSPSYIYPFWSRGVFHGVIHRCLSPVAASAQLRFQSLFYFTLGFAWCTFAPFAFRLYYFFLLRAYYVKAGPDIDHDFRPRYQPWEERIIVAPDGDFYRILGDGSASITTGVIAAVTPRAIRLTDGSKLSADVIVTATGMRLRFAGGIRISVDGVAFDPTSRFTWKAAMVEDLPNVVFPWGYAYKSFMLGYDVAARLACRLLGQMRREGHCMIVARCPDDVKASMDVLPLLRLKSTYVRLGQSSLPKGGDRPPWTPRSWYWKDLVSSVWGDVRTGLERC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJ97</accession>
    <name>A0A367LJ97_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJ97"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="170" mass="18671" checksum="E94700A0B9C7D12A" modified="2018-11-07" version="1">MIVGQQKKKKHLVPTLHTYIPGRARYLPVAARVPCDEALFYPDARAKHLSHLLLGLPAHMAAHSSLPPPDHTSPRPRAASLLAHRLATIGGGREGEGEASSLSCQRYPPARELPLSSHPPNPTDCNPPRRLPSTDTDIISKLRFCYPFTSLPFPSPSSTPYLDTLPTRQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJR4</accession>
    <name>A0A367LJR4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">3-hydroxyanthranilate 3,4-dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_6375</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJR4"/>
    <dbReference type="STRING" id="1330021.A0A367LJR4"/>
    <dbReference type="OrthoDB" id="204928at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000334">
        <property type="term" value="F:3-hydroxyanthranilate 3,4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046874">
        <property type="term" value="P:quinolinate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06123">
        <property type="entry name" value="cupin_HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000093">
        <property type="entry name" value="3-hydroxyanthranilate 3,4-dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00825">
        <property type="entry name" value="3_HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010329">
        <property type="entry name" value="3hydroanth_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03037">
        <property type="entry name" value="anthran_nbaC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15497">
        <property type="entry name" value="3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15497:SF1">
        <property type="entry name" value="3-HYDROXYANTHRANILATE 3,4-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06052">
        <property type="entry name" value="3-HAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI14617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="21198" checksum="7BA7D4255E632CC0" modified="2018-11-07" version="1" fragment="single">LAPPINLPKWLKDNASLLQPPINNYCVYDKDMTVMIVGGPNARTDYHINETPEWFYQYRGAMLLKVVVDGAGFRDVVIHEGSFFLLPPGVPHNPVRFANTVGIVIELPRPAGSVDRLRWYCTACEGGVVVHEAAFHCTHLGSQIKAAVQDFAADEEKRTCHKCLRLADAAPAPGSIPDPNLEPGDELRVKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJR9</accession>
    <name>A0A367LJR9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_6859</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJR9"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="71" mass="7676" checksum="94C6A54B974A9D18" modified="2018-11-07" version="1">MQTGAPTYVQTHPCFCVTSSPPTHSRGHRQAWLGSGSPNNTPIAGKPFLHVPAYHSFHRLSVAGLPQDQVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LK29</accession>
    <name>A0A367LK29_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7055</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LK29"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="74" mass="8427" checksum="6A07B3917B72E255" modified="2018-11-07" version="1">MGSDRSDRSDRHVQVFLQITDLLITYRYVRVLQVGTLKYLEKIISISFSHLLNTNTSPASNSSSIASFRLLPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LK79</accession>
    <name>A0A367LK79_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_6519</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LK79"/>
    <dbReference type="STRING" id="1330021.A0A367LK79"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="7">
        <location>
            <begin position="293"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="536"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="579"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI14845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="627" mass="67543" checksum="C2EF08CE31624728" modified="2018-11-07" version="1">MAHRHHQNPLRDPLQYAAKKTKLPVGGSPAYDYVIVGAGAAGCVLASRLSEDSSVSVLLLEAGGNNNVFRSKVPSLAGYLWGSKHDWSYETVSQAGVAGRRLWWPRGKMIGGSTSINAMMYHHCSASDFDEWASVYGCKGWSYDDIAPYFRRMESFHPSPSHPGVDLSHRGSDGRWHTGFMPVASIIAKGFIPACQQVGIPVVSDFNTPAGTLGASRFPSFVDPAGGRSSLATAFLSPDVMKRKNLYVAIHCHVSKVLLDGDGPTPSAVGVEFRGGQDCFQVLARREVILCAGAVNTPQILMLSGIGPGDHLEKHGIPVVRGNDAVGENMKDHLAIPVYGKAKKGQTMNYLTNPLRAILALLQWLIAGRGPLVSNFAEAAAFIKSTDQDSKAGPDLEIISSPVGINYRDKKIVVIDKNAAGNFVIGLRPQSKGSIKLGSGDPFDTQLQKADERELTAVIDPRYLTDEGDNDVKVLVTGLRLCIKILRSAAFSEFVEPCQNDDPWSVFWPYSSRDADGIPDEELISYLKRKAVTVFHPVGTARMGPSPSDSVVDLECRVHGVDGLRVIDASVFPEQISGHPCATVGAVAYKMSEMMAKRGGGSCGSFILPSSMIMESSFIHATPLPHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKC6</accession>
    <name>A0A367LKC6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Succinate/fumarate mitochondrial transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_6513</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKC6"/>
    <dbReference type="STRING" id="1330021.A0A367LKC6"/>
    <dbReference type="OrthoDB" id="204711at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005469">
        <property type="term" value="F:succinate:fumarate antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000021">
        <property type="entry name" value="SFC1p Mitochondrial succinate-fumarate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF2">
        <property type="entry name" value="SUCCINATE_FUMARATE MITOCHONDRIAL TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="96"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="201"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI14850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="32954" checksum="8F0482187D613717" modified="2018-11-07" version="1">MAGDSNKKPPTAATNLIDTIKVRMQLSRRARMPGAPKRGFIRTGLSIVQKETPLGLYKGLGAVLTGIVPKMAIRFTSFEAYKQVLADKQTGKVSGTAVFVAGLAAGVTEAVAVVTPMEVVKIRLQAQHHSMADPLDIPKYRNAAHALYTVVREEGVGALYRGVSLTALRQGSNQAVNFTAYAYFKDALRKMQPGLEASSPLPSWQTTIIGLVSGAMGPLSNAPIDTIKTRLQKTPAEPGVGAWSRIVRIASDMFKQEGFHAFYKGITPRIMRVAPGQAVTFTVYEFLKDQLERSNLSLGGGSYEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKN1</accession>
    <name>A0A367LKN1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_6842</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKN1"/>
    <dbReference type="STRING" id="1330021.A0A367LKN1"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000003">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF4">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="348"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="10">
        <location>
            <begin position="38"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="480"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="490"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI14969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="503" mass="53681" checksum="44108D8E99409F08" modified="2018-11-07" version="1">MSYSHVGAPTVFNGSDSALGGDATVTNLNQWYQAGDQAFILLSSCLVLLMVPGIAFLYSGLARRKSALSMLWVVAMSFSVVIFQWYFWGFSLAFGQASGNAFIGDLGFFGLRGVLARPSPGSPLIPALLYALFQMMFCAVTAALTVGAVAERGRVVPAVVFVFFWATAVYCPLAYWVWNPNGWAVKRGVLDYAGGVPVEIGSGCSALAYSWVLGRRNDKLMVNFRPHNVSLVALGTSLLWFGWLGFNGGSAFGANLRAVMACWNSCLTATFAATTWCLLDYRLTKKWSMVGWCSGAISGLVAATPASGFIEPWASIIMGVVSGVACNFGTHIKHLVHIDDSLDVFAEHAIGGCVGLIFNGFFATGRIIGLDGVNVGAKGGFLDRNFALLGWQVAVIVASSAYAFVVSALVAKAVDLVPGLGLRASDEAELLGMDDNQHGEYSYDYVEVRRDFLAWSPHRDEPAADGESFTPQHGILLHAEIARSSDGEKTSPSSSSQVEAKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKY0</accession>
    <name>A0A367LKY0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Threonylcarbamoyl-AMP synthase</fullName>
            <shortName evidence="14">TC-AMP synthase</shortName>
            <ecNumber evidence="3 14">2.7.7.87</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11 14">L-threonylcarbamoyladenylate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L249_6823</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Likely catalyzes the conversion of L-threonine, HCO(3)(-)/CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate. Required for normal translation, by ensuring translation fidelity at the level of codon recognition, appropriate translation initiation selection and maintenance of reading frame. Also involved in telomere replication. Binds to single-stranded telomeric (ssTG) DNA and positively regulates telomere length.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the SUA5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.87" evidence="3 14"/>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKY0"/>
    <dbReference type="STRING" id="1330021.A0A367LKY0"/>
    <dbReference type="OrthoDB" id="412787at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061710">
        <property type="term" value="F:L-threonylcarbamoyladenylate synthase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.870.10:FF:000008">
        <property type="entry name" value="Threonylcarbamoyl-AMP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11030">
        <property type="entry name" value="Threonylcarbamoyl-AMP synthase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="Sua5-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038385">
        <property type="entry name" value="Sua5/YwlC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005145">
        <property type="entry name" value="Sua5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010923">
        <property type="entry name" value="T(6)A37_SUA5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050156">
        <property type="entry name" value="TC-AMP_synthase_SUA5"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00057">
        <property type="entry name" value="L-threonylcarbamoyladenylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490">
        <property type="entry name" value="SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490:SF16">
        <property type="entry name" value="THREONYLCARBAMOYL-AMP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03481">
        <property type="entry name" value="Sua5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004930">
        <property type="entry name" value="Tln_factor_SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="YrdC-like" evidence="16">
        <location>
            <begin position="42"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00056339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR004930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR004930-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCI15096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="433" mass="45973" checksum="A534D29937275CDD" modified="2018-11-07" version="1">METRILALPPALNLGHFDDGNDHPLEQWHVNATSRHHHHHHHHHLDTAATMLRSQDALPVAFPTETVYGLGADATRSAAVRAIYRAKGRPSDNPLIVHVADLQMLRRLLGPSGELPAIYGPLVDRFWPGPLTILLPCPEPSPLAPEVTAGLSTFGVRIPASPLALTLIKLANVPVAAPSANASTRPSPTTAQHVVDDLGGRIELVLDGGPCRVGVESTVVDGLCSPPAILRPGGVAIEDLRACPGWASVVKAYRDHGEEGKAVPRAPGMKYKHYSPKANVILYEASNRDATAGIPPADVGLACTAARVVNGSPCDMARIVGVVRTMRWKPGAGLYCDDLQPAVPLEQGPKESISAYHVLVGHLNDQNGSHIGFVYDICLGTGTVGIAQGLFSALRELDRRGADTIFVDGIDGELDIAAAVMNRLRKAASETRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLL7</accession>
    <name>A0A367LLL7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PXA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6486</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLL7"/>
    <dbReference type="STRING" id="1330021.A0A367LLL7"/>
    <dbReference type="OrthoDB" id="5282002at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046824">
        <property type="entry name" value="Mss51-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032717">
        <property type="entry name" value="Mss51_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003114">
        <property type="entry name" value="Phox_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28069">
        <property type="entry name" value="GH20023P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28069:SF1">
        <property type="entry name" value="PROTEIN MSS51, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20179">
        <property type="entry name" value="MSS51_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02194">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13824">
        <property type="entry name" value="zf-Mss51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00313">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51207">
        <property type="entry name" value="PXA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PXA" evidence="1">
        <location>
            <begin position="541"/>
            <end position="721"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="969" mass="108012" checksum="84D6AAA56D744357" modified="2018-11-07" version="1">MEPALRKATLTLCGRCSTSLRRQVTSRSSGILSLAPGRIRLSNRRITNARAFTTEAVAAADETRPSTSVLLKPENLFHPFSSSPVADFRRRAGFMRQQAYCPHPDHQLTRLPTVGPVPEGDGGEGCREMAPAHVDFECPDCGLPVYCSKEHWMDHYDEHLKICDTLRQINEDDHDLRSGRVFHEANLPDFQLEEAAVNMTNWDTFMYTREFRAVDSDRSMRQITRLLTYPVTIGSVLHELSPYDFKKGKRLTVEGLKSLSALRYNLHPPKNGRGFSVSELKPEPPAMRIFILGARAESSLPRPIWVQLAHLFPATRLHLVFIGPESMANRDDEFPLPKRTASNPFGAVVEDRVWYQMKMSTIVDYYHTIHKTGYFAPYDPYFDCFVLFHPGLGHPASSHEWEETLPMLLETKVPIISTGYTQFDLERDVDWVKKQSKGEFDVLLEPGENLFRSLRWDLNDMDPQDVSCGNWGVWAFRGKRYVPRGVDESLNLGSTCDEAKRGPAMSGETESDRATQALVRRTLCPQQTRDKETQLPPLTSRNDVDFELYALLAIVLREYVQRWYGNMTTDETFVAEIVHVVAHCSRALEQRIRKLDLVSLLFDEMPQLLDQHVSGKTPYRAAHESLVRPPLAIDLHQAYHALCPFPPLDADQVENEADYRQLVVYAVLAVLLPTEDLENPCLTALVGQIFSELVIGNLIIGKAAQPWLILEGICILARNLENKSPSPKDAASAQSPAVQTWLRSMAKVALALLSWIWLLVGALATSSSLPPRRSCASSSSSSSRAKTTPVLEFAAWRCAGNLLELSSRMPWLEGFLSLARFGAVHGPGHVAGVDGAVDRLLAHHLEALLSPSRLSSGLKAIRGAVFPNNAPGPSSLTPPSSEAELQALRRRAALSLWRAVVPAAAAGRVYLAAGSDAEAVDQLEGMLLVLGDVYCNKHLLYAALELLLVRLMPELSEKGVADLWEERLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLM6</accession>
    <name>A0A367LLM6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">40S ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_6737</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLM6"/>
    <dbReference type="STRING" id="1330021.A0A367LLM6"/>
    <dbReference type="OrthoDB" id="10258210at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.860.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="entry name" value="30s Ribosomal Protein S19, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_uS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_uS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_uS19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005713">
        <property type="entry name" value="Ribosomal_uS19_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_uS19_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003121">
        <property type="entry name" value="PRK04038.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01025">
        <property type="entry name" value="uS19_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="RIBOSOMAL PROTEIN S19P FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="Ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI15336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="21061" checksum="24CB03B3BCBBCCB2" modified="2018-11-07" version="1" fragment="single">PAQRLQYCLSTDRYCIRPSTDQIRSSNNIAIMADEYNAEEAAELKKRRAFRKFSYRGIDLDNLLDLSSDQLRDVVHARARRRITRGLKRRPMGLIKKLRKAKQEAKPNEKPELVKTHLRDMIVVPEMIGSIIGIYSGKEFNQVEIKPEMVGHYLAEFSISYKPVKHGRPGIGATHSSRFIPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLN9</accession>
    <name>A0A367LLN9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_6544</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLN9"/>
    <dbReference type="STRING" id="1330021.A0A367LLN9"/>
    <dbReference type="OrthoDB" id="19923at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI15346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="23389" checksum="4111BE42575FBA8C" modified="2018-11-07" version="1">MVERLSAATAMVGLVADGGRISETMMMMTSSSSPALTRALLEMKQCRSTVQVLFKALCQLEAGRLPFPERASWIAVEDVVASLTDCVLAVVELQAVLLGGEQKRRRTSLEGGGLKLEEREEQEQDEEEEEVDALCLRIHWQLVSMTLMASILKMRSAQADTSLRPPPRCKTLADVPALSLLPLPLTTDELGPGRDLYSAAVYARAVAPFASCPLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLU7</accession>
    <name>A0A367LLU7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Midasin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_6503</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the midasin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LLU7"/>
    <dbReference type="OrthoDB" id="5186at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000142">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000582">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000712">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001368">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040848">
        <property type="entry name" value="AAA_lid_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048617">
        <property type="entry name" value="MDN1_AAA_lid_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012099">
        <property type="entry name" value="Midasin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041190">
        <property type="entry name" value="Midasin_AAA_lid_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103:SF2">
        <property type="entry name" value="MIDASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103">
        <property type="entry name" value="MIDASIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17865">
        <property type="entry name" value="AAA_lid_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17867">
        <property type="entry name" value="AAA_lid_7"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21108">
        <property type="entry name" value="MDN1_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010340">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="12">
        <location>
            <begin position="4715"/>
            <end position="4914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="598"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="4077"/>
            <end position="4596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="598"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="608"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="4121"/>
            <end position="4130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="4131"/>
            <end position="4148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="4156"/>
            <end position="4185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="4189"/>
            <end position="4216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="4239"/>
            <end position="4250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="4256"/>
            <end position="4270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="4271"/>
            <end position="4282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="4289"/>
            <end position="4299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="4308"/>
            <end position="4329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="4330"/>
            <end position="4342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="4349"/>
            <end position="4367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="4368"/>
            <end position="4379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="4432"/>
            <end position="4447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="4457"/>
            <end position="4468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="4475"/>
            <end position="4515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="4554"/>
            <end position="4569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="4570"/>
            <end position="4591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR010340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI15357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="4924" mass="549213" checksum="26D73AD786FF660B" modified="2018-11-07" version="1">[encoded data, 4924 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLW3</accession>
    <name>A0A367LLW3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">DNA replication complex GINS protein PSF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_3463</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.</text>
    </comment>
    <comment type="function">
        <text evidence="1">The GINS complex plays an essential role in the initiation of DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the GINS complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the GINS1/PSF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLW3"/>
    <dbReference type="STRING" id="1330021.A0A367LLW3"/>
    <dbReference type="OrthoDB" id="10252587at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902983">
        <property type="term" value="P:DNA strand elongation involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11710">
        <property type="entry name" value="GINS_A_psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21696">
        <property type="entry name" value="GINS_B_Psf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.1030:FF:000003">
        <property type="entry name" value="DNA replication complex GINS protein PSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005339">
        <property type="entry name" value="GINS_Psf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056783">
        <property type="entry name" value="PSF1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914:SF2">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12914">
        <property type="entry name" value="PARTNER OF SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24997">
        <property type="entry name" value="PSF1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GINS subunit" evidence="8">
        <location>
            <begin position="46"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication complex GINS protein PSF1 C-terminal" evidence="9">
        <location>
            <begin position="156"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI15426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="205" mass="23246" checksum="C05FA818FEEA2900" modified="2018-11-07" version="1">MYGDLGLKLVKNAKRTQSLAHLPPYQTELVREVAREVRDLDKDVMDILEPFQGSFDPNADQSVACTLLVNHLSMRRNKRCLLAYHRTRTDKLEELAWSGADIVDLSGQQVRESEGATSSLSPHEEDYVRQYSELLAAYKGQWTDIDLTGSLEPPRDLFIDVRVLKDAGEIQTEYGAITLTKNSQFYVRQGDVERLIAQGYLQKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LM01</accession>
    <name>A0A367LM01_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4110 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_3614</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LM01"/>
    <dbReference type="STRING" id="1330021.A0A367LM01"/>
    <dbReference type="OrthoDB" id="4447at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025183">
        <property type="entry name" value="DUF4110"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052588">
        <property type="entry name" value="Kelch_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46063">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46063:SF1">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13422">
        <property type="entry name" value="DUF4110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4110" evidence="2">
        <location>
            <begin position="641"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="715"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="616"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="645"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI15441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="740" mass="84040" checksum="4F5D87AF0EE5A2B7" modified="2018-11-07" version="1">MMSSRSVTRLGEACRYKDAHCILCLLVEPRRDTFCPAAWSWEKTVGRTMAKDKKKPSESKKAKKAEKAAKQASKGEKKAKTKAARLDGSDGEDVDLDEVLEAYRRQQEQFHKVTETICDGPPRPRAASTLLAAPHDSNSLLLFGGEYFNGSLANFFNDLHIYNIARDEWRSVSSPNAPLPRSGHAWTRASNPSFVYLFGGEFSSPKQGTFHHYSDFWRLEPATREWTKIESRARDKSPPARSGHRMTYWKQYIILFGGFQDTSNQTKYLADLWIFDTVHYLWHCAVLPPAQLKPDARSSFTLLPCEQGAVLYGGYSRVKANVTIKKKGSKTQSSGNKNVLVPRVHDDCFFLRMALPPVGASPETPPTVRWERRKKPANAPNPSRAGATMTWHKGRGIMFGGVHDVEQSEEGMDSEFFNQLFAWNIERNRFMPLSLRKPRQQKKAVTEQRLGRRGRAQANEEELLRQLAALETGASLDDADDMELDWRPEQGAAEDEKPVREMPVSMEPPHMRFNAQLAVQDDVLYIYGGTFEKGDREFTFDDLFAIDLSKLDGCKEVFSRPVEDWVESEDEDEDEDSEGDEGDDEEDDEEDDQTDDEGEAMHTPSKRKKHEREVSSPDTASEASSWSATREDEETETTATSVDDGLPHPRPFESRREFFARTSAEWQEVLMTSLRWKGTQPETMSIKEIKTKAFELSEEKWWDCREEMTALEEEHDAAGIQEVVSLSERGDGSTGGAKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LM31</accession>
    <name>A0A367LM31_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_3470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family. PalF/RIM8 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LM31"/>
    <dbReference type="STRING" id="1330021.A0A367LM31"/>
    <dbReference type="OrthoDB" id="7785529at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF161">
        <property type="entry name" value="PH-RESPONSE REGULATOR PROTEIN PALF_RIM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="3">
        <location>
            <begin position="382"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="290"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="329"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="432"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="543"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="597"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="49"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="332"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="449"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="461"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="543"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="562"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="612"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="655"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="671"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="708"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="729"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="763"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="786"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="844"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="861"/>
            <end position="871"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI15471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="871" mass="92700" checksum="73EAB1B91F96D7F1" modified="2018-11-07" version="1">MVASHEIETGPAWPERDCHGPVTTRRRRRRRRRRRRRRRDAHRPVVLMPLPSLSGNPASAPAASHAEAAGPSAPLSPAISPSSKTPSSTSRSSLLSRLSRPLALPLRSRNRNVVDFHVRCDEPYRKYGAGDPVRGSVVLVVVRPLRITHLVASLHGHVRVLKDPTSTAKAQHAALSSTGSSVSPRYHGNGLASLFQDEQVLSGEGRLEPGKYEFGFDLVFPDAELPSSIDFERGTISYMITATLTRPTTIAPTSSCDRKVTLVQKIDIGMLSPPRPRTIFLEPISKRARRKKATTTLERTPTASLAEANDAASEPDLAERYTITDETVTSDARNHIPSDLRSEVSGESGRTASTAISRAEAAQLSQIGAASMSPAAKQQVVDDKTITATIELLRGGCLPGDTVSARVTVQHIKRVKSMTGVIVTLFRQGKIDTSPPPSRFSTTASNRADAGKPDKEEMFPRSRTSLGGLSLSSTSSTSVFRKDLDQNAAPLIIDPATLQASVTISVKVPDDAFPTIKGVPGDMISFKYQVEVVVDLGGRLASQLQGGQSSSSRLGPYGNGGSEQSAGSYAPWRSTNIADTAQLRREKGVISVSMETVVGTTDSSRSRKLMKKSPEARTVRIHESDDDGGERPGSANRANGQPAAPQHGPDGYQFTPPPGGPPSVPPPPSQPDRETSFRDEPRANGFPPDAAPSYIPAPPLLAVQSNLTEKERIRQAETRLLPSQPPAVAPSASAPGTSARGHDGDDIYDAEDAPPVVRPEPSAPCDGADDAGPSAPAEELLGQGHQSEDKLERERLRLMGEASAPPEFPDDADRSGSSHPVVPGDHGLDAEPSAPRLDDNDYGAGYGAVAGPSGAGSSGGRHLEQLPAYER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMC8</accession>
    <name>A0A367LMC8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_3416</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMC8"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI15595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="160" mass="15465" checksum="C0BE80BEFB6483A0" modified="2018-11-07" version="1" fragment="single">GPLLYVRNKADERYRGLAAAAAAIKASPAAAINTSLAAAAAAINTSPSAAAAAINTSPAFPAAAIDIYAATSGIAGRQEGVSRYTAPASISTNAFLAASYAARVIEAAAIGLCRQALSITIAAALVPLASFKAAAAAAASASKATAASSAAEEEETAEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMX5</accession>
    <name>A0A367LMX5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vacuolar calcium ion transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_2757</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Vacuole membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMX5"/>
    <dbReference type="STRING" id="1330021.A0A367LMX5"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000011">
        <property type="entry name" value="Vacuolar calcium ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004798">
        <property type="entry name" value="CAX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00846">
        <property type="entry name" value="caca2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00378">
        <property type="entry name" value="cax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF22">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 10" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="173"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="341"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="372"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="12">
        <location>
            <begin position="107"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="12">
        <location>
            <begin position="308"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI15768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="464" mass="49169" checksum="84B037A381036A1E" modified="2018-11-07" version="1">MNRKPAAAGEQTPLIRHDQHHVASSSSSSSPPPPPALLPSSCRRRSGLCAFFLDSKHTPGRESGSFAVRGLAHTWHVTKVTLLSNYVNFLLVFVPLGIVAGACKWNSTAVFTINFFAIIPLAAVLSFATEEISIKLGETMGGLLNATFGNAVELIVSIVALKDGQIEVVQSSMLGSILSNLLLVMGMCFLFGGIVHRGQNGEGTEQRFSSAVAQTTCSLMTLSSASLVIPAALYAVLTQNGSDEKLTSILILSRGTAIILFLLYALYLVFQLRTHSNLFDPEDPPESATVEGAEEEGEIPSMSAPAAAAVLVVVTVLVAICADYLVGSIDDIVATAHISKAFLGMILIPIVGNAAEHVTAVVVALRDKMDLAMGVAIGSSIQIALGVTPFLVIVGWIIGQPMSLHFETFQTVAFAVSVLVVTYTVQDGRSNYLEGAMLLALYIIIAVAFYATPSDVMDNTWLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LN07</accession>
    <name>A0A367LN07_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_2772</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LN07"/>
    <dbReference type="STRING" id="1330021.A0A367LN07"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI15826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="127" mass="14720" checksum="C18E7E22EA7FC030" modified="2018-11-07" version="1" fragment="single">TRYKDIRTFSRKKGEFSAFLTNLKDKIRTDKATFRDEEDRIGFLFRSLEGKARKTLETRYDSIKRPFSGLAEIIYLLTKTKDDSLSYKDFCGYIKDSPNDLPALAKYSLSILLPKTPLLNRQIDPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LP49</accession>
    <name>A0A367LP49_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_2373</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LP49"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI16213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="106" mass="12235" checksum="9F80B0CF0A54E98E" modified="2018-11-07" version="1">MGVQNLRIQSQAAKITEAVESGKKLYKRMCFSLFVYCISFFSLSSLRRYASKAYPERRVYAPKFTELLRRGSTLFRPGLARARGWRVVQVMKTHFPSPNTPNSKPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPG8</accession>
    <name>A0A367LPG8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP-dependent RNA helicase DOB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_3167</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPG8"/>
    <dbReference type="STRING" id="1330021.A0A367LPG8"/>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18024">
        <property type="entry name" value="DEXHc_Mtr4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13154">
        <property type="entry name" value="KOW_Mtr4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000083">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000141">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.300:FF:000001">
        <property type="entry name" value="Mtr4 exosome RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF7">
        <property type="entry name" value="EXOSOME RNA HELICASE MTR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="166"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="427"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="368"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="383"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI16333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1078" mass="121805" checksum="12E0CD2B38B12B45" modified="2018-11-07" version="1">MDEMFDVFEGKAVPQSDSDAEKATQTSRTRDKSKKRKADEAINGAAVKEAADVDMGDAPESSNDDDSDEESDTPSQQDKKRRRKEDGAGGPVITDTFQTAQSREVAGATTLLPQDASLVLSHNIQHQVALPPDLDYEYVPLSEHKSPDEPARTWTFKLDPFQSLSVASIERDESVLVSAHTSAGKTVVAEYAIAQCLKRNQRVIYTSPIKALSNQKYRDFDAIFGDVGLMTGDVTINPTASCLVMTTEILRSMLYRGSEIMREVAWVVFDEIHYMRDKIRGVVWEETIIMLPDKVRYVFLSATIPNAFQFAEWIAKIHHQACHVVYTDFRPTPLQNYFYPAGGKGARIVVDEKGIFNEQNFNQVMKEVEEKRGSDPADPNARMKGKGRNKKTNKGGVDEGSDIYKIIKMTIKKKFNPVIVFNFSKREIEQMAISVSNLDFNDDSEKAMVKKVFQSAMDTLSEQDRELPQIVHILPLLERGIGVHHSGLLPLLKETIEILFQESLIKVLFATETFSIGLNMPAKTVVFTQASKWDGIKVRPITSSEYVQMSGRAGRRGLDARGIVIIMVDDKLEPDVAKHMVTGQQDKLNSAFHLGYNMILNLLRIEAISPEYMLEKCFHQFQNAASVPALEKELMALQQERDGMAIPDEATIKDYYQIRQQLNTFTRDMRAVIQHPQYCLDFLQPGRLVQIYNPKQSPDSVGGGVDFGWGVVVNHSARKGPKMGEPQYSMQESYMIEVLLPISASSVDIAPSQPAGEMPPGLSPSMSEQDTIHEVVPCLLTCIKAISQIRIFMPKDGLKTEQDKEQAHRSLTEVKRRFPDGVPILDPIENMDISDESFKKLLRKIEVLESRLLANPLHMSPLLPSLWDQYHNKMQIQERVREKKKAMAKAHRAGTNGGAQVAEAVQLKARAACEISSTEGHELVLSELLFDRFFNELTAEKCAAVLSCFIFDERVDTDALKEELQKPYREIQAKARMVAKTSQECKLDMNEEEYATSLKWQLMETVYRWAQGRPFLEICKLTNVYEGSLIRLFRRLEELLRQMAQAAKVMGNEDLMKKFEESLQKIRRDIVATQSLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPK2</accession>
    <name>A0A367LPK2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7729 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_2157</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPK2"/>
    <dbReference type="OrthoDB" id="2564812at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056146">
        <property type="entry name" value="DUF7729"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39460:SF1">
        <property type="entry name" value="C6 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39460">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24855">
        <property type="entry name" value="DUF7729"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016759839" description="DUF7729 domain-containing protein" evidence="1">
        <location>
            <begin position="33"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7729" evidence="2">
        <location>
            <begin position="50"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI16339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="285" mass="30400" checksum="15AAF3B417274239" modified="2018-11-07" version="1">MASWWSADAPLACSRLRLALALFALFTCGVEALSTPSPDAGRTTRRDMALPSPFDDGPPSLFQGAGSDDRCVTFMANLLSDGTFKSCHPVSMLLQTSTALFEAEKQTTSLVRVLDAACSVDVSVCADYLTKAAERLGDRANCRAELDQSQPRVVQAQRGLRAYRTLYAASCLEDGGVYCFAQSASNLSDPSNSYLYFIPLGMALPGASTPSCNRCTRDIMNVYHASAANRGHLVSEKYAEAAQQINVVCGPGFVNATLPRPKSAAGGRCRHVLPVAAVVILAMML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQ96</accession>
    <name>A0A367LQ96_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_1984</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQ96"/>
    <dbReference type="STRING" id="1330021.A0A367LQ96"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006413">
        <property type="term" value="P:translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000136">
        <property type="entry name" value="DnaJ domain-containing protein Psi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000002">
        <property type="entry name" value="Dnaj homolog subfamily b member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000013">
        <property type="entry name" value="DnaJ subfamily B member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051339">
        <property type="entry name" value="DnaJ_subfamily_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078:SF553">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="146"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="315"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI16412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="373" mass="40644" checksum="4407697EDE305B7D" modified="2018-11-07" version="1">MVKETKLYDTLSVKPDASQDEIKKGYRKAALKWHPDKNKDNPNAAEKFKECSQAYEILSDPEKRKIYDQYGLEFLLRGGAPPPEGGANPFAGGGMPPGFDFGGAGGGGMPGGARTFHFSTSGGPGGGGFSFNNPDDIFAEFLRQQQSSGGGGMRGGGDEDDFANIFGSMGGGGPRTGRSRMRPTGFADSRKRDPTPEITTVERSLPLTLEELFHGVTKKMKIKRKTFDESGKRVQTDQILEVPIKPGLKKGSKIKFNGVGDQVEGGRQDLHFVVEEKEHALFKREDNDIVHTVTLDLKEALTGWKRTVTTIEGRQIPLDKGGPTQPGSEDRYPGLGMPVSKKPGQRGDLVIKYKVNFPSTLTATQKQKLREIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQC9</accession>
    <name>A0A367LQC9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="23">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">L249_2909</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28 29">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 23">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38567"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:38568"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38583"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:38584"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine(out) + ATP + H2O = a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66036"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:22801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:66037"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 22">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="23">Membrane</location>
            <topology evidence="23">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 23">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="23"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LQC9"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070867">
        <property type="term" value="C:mating projection tip membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990531">
        <property type="term" value="C:phospholipid-translocating ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140351">
        <property type="term" value="F:glycosylceramide flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090554">
        <property type="term" value="F:phosphatidylcholine floppase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140346">
        <property type="term" value="F:phosphatidylserine flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090556">
        <property type="term" value="F:phosphatidylserine floppase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099040">
        <property type="term" value="P:ceramide translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007163">
        <property type="term" value="P:establishment or maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02073">
        <property type="entry name" value="P-type_ATPase_APLT_Dnf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000048">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000108">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF180">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE DNF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 21 23" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="24" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="13" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="10 22 23" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 21 23" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 23" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="511"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1138"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1169"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1220"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1261"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1286"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1326"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="26">
        <location>
            <begin position="110"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="27">
        <location>
            <begin position="1106"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="287"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1377"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1451"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="25">
        <location>
            <begin position="1517"/>
            <end position="1559"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="24">
        <location>
            <begin position="874"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="25">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="25">
        <location>
            <begin position="1377"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="25">
        <location>
            <begin position="1470"/>
            <end position="1481"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="20">
        <location>
            <position position="627"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="627"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="627"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="628"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="629"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="629"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="761"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="802"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="825"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="860"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="940"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="941"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="942"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="1054"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="1060"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="1080"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="1083"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="1084"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="1084"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00050913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00052223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="RCI16619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1559" mass="174761" checksum="54E502DABD7FE332" modified="2018-11-07" version="1">MTTATGSGPGADGNPQKLEHSHRTRWATRKMTIKSGRSKRLSLLNRMQQRKRASNEKQNPPAGDNAEPPLTDRSSEDGSDASSQSEDNGRTLYFNLPLPDNLLSDGHPIQLFPRNKIRTAKYTPLSFVPKNLWFQFHNVANIFFLFLVILGIFPIFGGVNPGLNAVPLIFIIVVTAIKDAVEDYRRTVLDNELNNAPVHRLSHWDNVNVEEGTVSSWRRFKKANTKLFGSMWHAIESLWSQKARATRAERKARKLLEGDQEDEVRPSVETIRTRMSVREALSSPFSRDSFKSAEDDIPMTPVGSPKALGDIPTIDLPDDRDAQRAAALRAMKSDLVNYRRAPEGAKFKKDTWKSIQVGDFVRIYNDDELPADVIILSTSDPDGACYVETKNLDGETNLKVRQALRCGRTLKHARDCERAEFHIESEPPQPNLYKYNGALHWKQTVPGCPEDEPESMTEPITIDNLLLRGCNLRNTEWVLGVVIFTGHDTKIMMNAGITPSKRSRIAREMNFNVICNFGILLIMCLLSGIFNGVAWAKTDASLHFFDFGSIGGSAAMSGFITFWAAIIVFQNLVPISLYITLEIVRTLQAVLIYSDIDMYYAKIDQPCIPKSWNISDDVGQIEYIFSDKTGTLTQNVMEFKKASINGQPYGEAFTEAQAGMQKRLGVDVATESVRIEAEIAEAKVKALASLRKLYDNPYLHDESVTFIAPDFVSDLAGHSGHEQRAANEEFMLALALCHTVIAERSPGDPPSMEFKAQSPDEEALVATARDMGFTVVNNNSDGIDLNVLGEDRHYPILNTIEFNSSRKRMSSIVQMPDGQIVLYCKGADSVIYSRLKRGEQQQLRRQTAEHLEMFAREGLRTLCIARKTLTQKEYDAWKKEHDAAAAALENREEKLETVAELIEQDLMLLGGTAIEDRLQDGVPDTIALLGQAGIKLWVLTGDKVETAINIGFSCNLLNNDMELIHLKLDEDETGETSDETFLATTEKLLEQNLQVFGLVGDDKDLAAAIKNHEPPAPTHGLVIDGFTLRWALNDRLRQKFLLLCKQCKSVLCCRVSPAQKAAVVAMVKTGLDVMTLSIGDGANDVAMIQEADVGVGIAGVEGRQAAMSSDYAVAQFRFLQRLMLVHGRWDYRRVAESIANFFYKNVVWTFGIFWFEIFCDFDITYPFDYTYILLFNLIFTSLPVGIMGVLDQDVSDKVSLAVPQLYRRGIERLEWTHLKFWLYMIDGLYQSVMVFFIPYLLFVPAQPVSFSGLGLEDRLRFGAYVAHPAVVTINAYILINTYRWDWLMLVVVSLSDLSIFFWTGVYSSFVSSGFFFKTAAEVYSEASFWAVFFIVPVICLFPRFAVKSLQKVYWPYDVDIIREQEKMGAFVHLTNDSSTSLRHGSDGGSQKSGTSKKAKHTLKASVDDDLRPIYPPSTATRTTHNRTHHGSDSTNFSADASLEAVAIATGANRLSMEAPPPDRPSVEVTRPSDERMRPSNERMRPSYDRMRMSMDRVRPSFEASSDFTSAARLQRIESTQTGGLKARLRGLSLTKNSGQNSPLSPRSPRSPRSPRLRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQK9</accession>
    <name>A0A367LQK9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Acyl-CoA dehydrogenase/oxidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_2553</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQK9"/>
    <dbReference type="STRING" id="1330021.A0A367LQK9"/>
    <dbReference type="OrthoDB" id="435240at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00567">
        <property type="entry name" value="ACAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000012">
        <property type="entry name" value="Acyl-CoA dehydrogenase fadE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.540.10:FF:000027">
        <property type="entry name" value="Putative acyl-CoA dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF12">
        <property type="entry name" value="ISOVALERYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016578">
        <property type="entry name" value="HsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="8">
        <location>
            <begin position="25"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="7">
        <location>
            <begin position="142"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="6">
        <location>
            <begin position="249"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI16708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="410" mass="44695" checksum="F63FFC3470809EB1" modified="2018-11-07" version="1">MSRLITRRLGVKTPRRWLMSMTGLSESQVMVREAVAKVCLTFPPDYWRQKDVKEEDPKEFHAALASNGWLGIALPESHGGSGLGISEATMMMQTVTESGGGMAAAQAIHGNVYATQPLVRFGSQELVAETVPAVVSGAARLCFAVTEPDSGLDTLSLTTSATRINDDEYSISGRKIWITCAQVASKMLLLARTGTARDALSLFCIDLDRTKPQLTMRRIRKMGSRAVDANEVCFDDYRVPVRCRLGPEGSGFRAVLHGLNAERCLLAGEALGLGYAALERASSYARQRVVFGRPIGTNQGVAHPLADAYMRLEAARHATYHAARAYDDNEDDKQAVSLGVAANSAKYLAAEAAFTACERAVLAHGGMGYAAEYDVERWFRDSLVPRIAPVSREMILNFIGEKVLRLPRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQL0</accession>
    <name>A0A367LQL0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Subtelomeric hrmA-associated cluster protein AFUB-079030/YDR124W-like helical bundle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_2962</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQL0"/>
    <dbReference type="STRING" id="1330021.A0A367LQL0"/>
    <dbReference type="OrthoDB" id="5338458at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047092">
        <property type="entry name" value="AFUB_07903/YDR124W-like_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021264">
        <property type="entry name" value="AFUB_079030/YDR124W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36102:SF1">
        <property type="entry name" value="YDR124W-LIKE HELICAL BUNDLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11001">
        <property type="entry name" value="AFUB_07903_YDR124W_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Subtelomeric hrmA-associated cluster protein AFUB-079030/YDR124W-like helical bundle" evidence="2">
        <location>
            <begin position="209"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="540"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="598"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI16677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="649" mass="72579" checksum="C28C905CABD12BF0" modified="2018-11-07" version="1">MVHDWSRDPFPRQQPFQQQCYPAGTRHPLFHRERYASDRQDSFQQDRYPIDGPDATRFQDQYDLHRRQPPMPQQIDEALRLHCGIAAKQYFVAAINEDGIPMTFFSPGLKLHDSAISHFFDASKFQQVMRKIDSGACPSLDDAFAFEDVMYDRQGALSRSRGLDKRRSSVFDDWGSPPRQGRKRQRARHPVAEEDEITMTMSSRRGIKVGDSEAVWSFYEQRFKNCQQTACKLIAKAWVKAVEPKKQSTHPYTGSDEKAPDWWPKPWGPTKDDKVRHKEPDHLYKRERVHLLAHILRLVVEPNAKQHPDIQKIGLNVDKLEEATNEALSAFFMDNETNAKKKPHLNEIFKMARQEARFKNGEIDDTTKVYVMAEDKMPDKYASDNDDGSLIKVEAEHHELQRSKPPATHCLIHAPTTTTTTTPTTTTTTPANGHALHGGPGSYMSDLPVRGASFHPPMIQTDLSPQQHSFVESGGMAVNEPAAVSAAGAPLSLDLVASPHHDSSRRPSVFSDYASPSGGSLYSQPWQQSSTGGSNAPSMYAYTGQQPTAQQPAPYVSQISPGQSFITSSFESSPRPEFDANGSGLFRSNDLASAAVGQQQQQQQQPPQQQPQPQQQQQQGYYLSGDGRGDLRVLSQVVDGGSKAAQSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LR15</accession>
    <name>A0A367LR15_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ubiquitin-activating enzyme E1 1</fullName>
            <ecNumber evidence="6">6.2.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">L249_2885</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + ubiquitin + [E1 ubiquitin-activating enzyme]-L-cysteine = AMP + diphosphate + S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.45" evidence="6"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LR15"/>
    <dbReference type="OrthoDB" id="10252231at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004839">
        <property type="term" value="F:ubiquitin activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03190">
        <property type="entry name" value="GST_C_Omega_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01491">
        <property type="entry name" value="Ube1_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01490">
        <property type="entry name" value="Ube1_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2660:FF:000001">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12550:FF:000001">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000015">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.60:FF:000001">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.180:FF:000001">
        <property type="entry name" value="ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.80:FF:000001">
        <property type="entry name" value="ubiquitin-like modifier-activating enzyme 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.180">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, FCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.80">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12550">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2660">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, SCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.60">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, UFD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032420">
        <property type="entry name" value="E1_4HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032418">
        <property type="entry name" value="E1_FCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042302">
        <property type="entry name" value="E1_FCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047047">
        <property type="entry name" value="GST_Omega-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016639">
        <property type="entry name" value="GST_Omega/GSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018965">
        <property type="entry name" value="Ub-activating_enz_E1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042449">
        <property type="entry name" value="Ub-E1_IAD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038252">
        <property type="entry name" value="UBA_E1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019572">
        <property type="entry name" value="UBA_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042063">
        <property type="entry name" value="Ubi_acti_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018075">
        <property type="entry name" value="UBQ-activ_enz_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000011">
        <property type="entry name" value="UBQ/SUMO-activ_enz_E1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01408">
        <property type="entry name" value="Ube1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF4">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16191">
        <property type="entry name" value="E1_4HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16190">
        <property type="entry name" value="E1_FCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09358">
        <property type="entry name" value="E1_UFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10585">
        <property type="entry name" value="UBA_E1_SCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01849">
        <property type="entry name" value="UBIQUITINACT"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01206">
        <property type="entry name" value="Xi.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01148">
        <property type="entry name" value="Xi_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00985">
        <property type="entry name" value="UBA_e1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="11 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="9 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 15" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="GST C-terminal" evidence="17">
        <location>
            <begin position="1216"/>
            <end position="1346"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="13">
        <location>
            <begin position="2210"/>
            <end position="2242"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="13">
        <location>
            <begin position="2243"/>
            <end position="2275"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="13">
        <location>
            <begin position="2276"/>
            <end position="2308"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="13">
        <location>
            <begin position="2309"/>
            <end position="2341"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="13">
        <location>
            <begin position="2343"/>
            <end position="2375"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="13">
        <location>
            <begin position="2376"/>
            <end position="2408"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="13">
        <location>
            <begin position="2410"/>
            <end position="2442"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="13">
        <location>
            <begin position="2444"/>
            <end position="2476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1594"/>
            <end position="1619"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="14">
        <location>
            <position position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RCI16896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="2569" mass="286680" checksum="ED816F6A0A97967E" modified="2018-11-07" version="1">MAADLGLLQGQKLPEVDLATRMQVDNSIIGTTDIDESLYSRQLYVLGHEAMKRMGASNVLVVGLKGLGVEIAKNIALAGVKSLTLYDHAPVQLADLSAQFFLTPADVGKPRDEVTVPRVAELNAYTPVKLHQTSGLEEDPSQFDNYQAVVLTNQPISSQKAIGDYCHSKGIYVVVVNTYGLFGSIFCDFGDKFSVIDTTGEAPLSGIIASIDEDGTVSALDETRHGLEDGDFVTFSEVEGMEGLNGCEPRKITVRGPYTFSIGDVSGLGTYKRGGIYQQVKMPELINFNNFTTSLKEPEFVISDYAKYDRPQQLHVGFQALEAFQLAKGRLPKPMDEEDAAVVLGAAKKFVEQESIDIELDEKLLKELSFQATGDLCPMAAFFGGTAAQEVLKAVSGKFRPIRQWMYFDSLESLPTSTPRTAELCAPRGSRYDGQIAVFGVEFQEKLANLTQFLVGAGAIGCEMLKNWAMMGLGTGPKGKIYVTDMDSIEKSNLNRQFLFRAADVGSMKSDCAARAVQRMNPHLEGHIETMKDRVSPDTENIFGEAFWQGLDGVTNALDNVEARTYVDRRCVFFRKPLLESGTLGTKGNTQVVIPHLTESYSSSQDPPEKEFPMCTIRSFPNRIEHTIAWSKEYMFEKLFVRAPQTVNLYLTQPKFLETAMKAGTGNQKETFETIRNYLTTERPRTFEDCIAWARMLFETEFSNKIQQLLYNFPADSATSTGAPFWSGPKRAPDPLKFDAHNPTHFGFIVAAANLHAYNFNIKPVSTDQAFYLRELDNVIVPDFTPDANVRIQVDDGQPMNAKDPNAGSDDGDELNKIVAAIPSAKTLAGFQLQPVEFEKDDDTNYHIDFITACSNLRAENYKIEPSDRHKTKFIAGKIIPAIATTTALATGLVILELYKIVDGKNDLEQYKNGFFNLALPFFGFSSPIESPKVQYRGPEGKVTLDKIWDRFEMDDVTLQELLDYFKAKGLTVGMLSSGVSLLYANFFPPSKLRNRYSMKLSLLLETISKKEIPAHQREVIFEIVAEDLDEADAEVPYIKVKTTSITDWVRPGDPSGEFKRQTSAFRDSISRKEGAAFPPARGRYHLYVSYACPWAHRTLIGRRLKGLESIISFSVVHWHLGDGGWRFVRGDDKEADMPGENVVPDPVPGHEGFTRLRDVYRESDEGFEGRCTVPVLYDKQTRRIVSNESSEILRMFATEFDDLVDAKYRAVVLVPDDLRAKIDETNDWTYDLINNGVYKSGFATTAEAYEKNVVALFEGLDRAEAQLVSSRQDGPFYFGKDLTEADIRLYVTLVRFDVVYVQHFKCNLRDIRSGYPALHRWLRNLYWKHEAFGQTTQFEHIKWHYTRSHTQINPHSITPLGPKPDMLPLEDEVPAVKAAESKYFKVKSMHSPDDYSVGWICAISTEYVAAQAMLDERHAGPSSVAKNDNNDYSLGRIGHHNVVIAVLPDGEYGLSSAASVARDLLHSFTSVRVGLMVGIGGGAPSSRHDIRLGDVVVSSSGRGQGGVFQFDFGKAIQECDFRETGFLNKPPQLLRTAVSGLAAQYEAEEHRLQEAVSQAIEKKPRLRKKYSRPAASTDRLYKPEVLHPLDDDSSCATACGDDPSKLVQRQPRTEEEDDPMIHYGLIASSNSLIKDALIRDSLAAKKDVLCFEMEAAGLMNHFPCLVVRGICDYADTHKNHEWQGFAAMMAAAYAKALLYRIPPNKIEAENKISEVLNGLQQDVAHLVRKQRDGECMNILRWLTPVDYAPQQSDFYARRQPGTGQWLLDSAQYREWLDAKGKTLYCPGIPGAGKTILTSVVVDDLNRRFDDTDACICFLYFDMRRLDEQGFADLMASLLKQVSENRAAMSQDIRELYARHSLKRTRPSTDELGQMLRSLLASLSRSRIFIAIDALDECQAFNGCRCRFLQFVFQLQTVSGANVFATSRPIPEIADYFKEAILLEIVANEKDIRLYLTGNMYRLPAFVRRDQQLQEDIERETVPMINGMFLLAQLYLDALVGKKSAYAVRVALQTLPTGSNAYDDAYRAAIQRIRDQEANQRTLATEVLTWIICAKRRLTTLELQHALATEVGHDDFRRDNISDVEDIVSACAGLVTVDKESDVIRLVHVTAQQYFDRERSTWFPDAEHLISTTCVAYLSFSIFESGPCKTRDEFEKRLETYRLYRYAAIWWGVHSLASSSLPYGVLAFLQCKPKVQGSGQARLVRFQPHVGTTGLHMAINFGMEEAADVLVESGQDVDSKDHDDRTPLHLAAGRGYEKAVGLLLEKGADHSLTERKGWTPLLCASGNGHLPIVRMLLDKGTEVSCADYEGRTSLHLAVEKGHEAVASLLLDKGAEVEPKNKMNYPSPLSYAADGGHEAIVQLLLDKGADAGVTDGDGRTPLHLAAQRGHEAVVSLLLERGADLDAARQKCHSTPLSLAAKYGHPAVVRLLLERGAGVDVKDWIHDRTPLSWAAGQGHERVIRLLLKRGADINSADEVYKRTPLSWAVKAILDAEDEWEIERESTDELDRRTSASSAVRLGYEPTLRLLLDNGGEYSDSDSTQGRDLKRVLLWAAGREYESSIRLLLERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LR35</accession>
    <name>A0A367LR35_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_2188</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LR35"/>
    <dbReference type="STRING" id="1330021.A0A367LR35"/>
    <dbReference type="OrthoDB" id="5330139at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI16916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="171" mass="19604" checksum="AECF8BD9654175D0" modified="2018-11-07" version="1">MRCRWRVGLAGGATGSAIAPRRRAFHQATALVSLERAPVRYKHLRWPEPDDWTTDEELPREYETEIWVGDKYESFVYLKPEVGTQLHSDIVRQRGSKDGIQVRSRKMGLKFYHDSRHFAHRSLSLPRLYLKSDLPMTPASHRGVTAATLWMTGEWWAITLNGGEDGTCVPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRA4</accession>
    <name>A0A367LRA4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mediator of RNA polymerase II transcription subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_3078</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Mediator complex subunit 7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRA4"/>
    <dbReference type="STRING" id="1330021.A0A367LRA4"/>
    <dbReference type="OrthoDB" id="10253553at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037212">
        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009244">
        <property type="entry name" value="Mediatior_Med7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044888">
        <property type="entry name" value="Mediatior_Med7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21428">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21428:SF11">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05983">
        <property type="entry name" value="Med7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0010">Activator</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI16975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="253" mass="28186" checksum="30C63067F0B97D2C" modified="2018-11-07" version="1">MADAEPHSLASTFPNPPPFWHDFTPEKIRRAEALRKTSTTAIAATTCSSRSDLPPDLVHLQPPREPKDGRWRVFGDQYMLDDKLPTLEEQGIANLQATGGPSSSRESKHYDRALELKCMAKSLLLNFLELTGLLSRSPAHAEAKMQDLRTLFINMHHVLNEYRPHQARESAMEMMQDHLDRTRAETLAIRTQVDKTRSVLEGLGSLAIGEVASLSVEERGAAADGHGLDALAEEEEEEERDRGVWAVVDEVLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRL6</accession>
    <name>A0A367LRL6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_1821</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRL6"/>
    <dbReference type="OrthoDB" id="4928171at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI17037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="241" mass="26921" checksum="BABAC4CE9C99ED92" modified="2018-11-07" version="1">MSRLGMHVSKGWAKPKCLTAMLTMLTLLLSPFLTGWRIRSPYLSPRRYASMLETKLSAKTTNFRPRIYKSRRDDDSFESVELFITTSLHHVPHYVPLPSLSPSLSPPRLWPIGRTTTTAETEAETEAETEAEMEERIPRYSSHDKMCQREGQSCATGLPPGFPSGCCGKLRCKPIPGLFGGGKCVKKNDDGGDDDDNKRMCKREGDRCSLALGPGFRSGCCHPLQCKTVPGQQQQQQQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRN9</accession>
    <name>A0A367LRN9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_1898</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRN9"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI17057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="66" mass="7527" checksum="712DEE8B191C1232" modified="2018-11-07" version="1">MSRNMPMDRLPEEAMLGGGTQLAEVEQRRDINCWRIFLEPLGVSTEDKAMRAPRLVEEERHGMLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRX8</accession>
    <name>A0A367LRX8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">arginine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Arginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_2387</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Arg) + L-arginine + ATP = L-arginyl-tRNA(Arg) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="2"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRX8"/>
    <dbReference type="STRING" id="1330021.A0A367LRX8"/>
    <dbReference type="OrthoDB" id="68056at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07956">
        <property type="entry name" value="Anticodon_Ia_Arg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000006">
        <property type="entry name" value="Arginyl-tRNA synthetase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000058">
        <property type="entry name" value="Mitochondrial arginyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="entry name" value="Arginyl tRNA synthetase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956:SF11">
        <property type="entry name" value="ARGININE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="ARGINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 10" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arginyl tRNA synthetase N-terminal" evidence="13">
        <location>
            <begin position="70"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="DALR anticodon binding" evidence="12">
        <location>
            <begin position="574"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="270"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI17204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="691" mass="77954" checksum="04AF2F4F3E486C04" modified="2018-11-07" version="1">MPLLITSALTYSCRILTRRRLITSRRHQRLYRSFTSMASDASFDALAKRFQHLPLIDRYPNCFPDRNPVDVYRAHITSILHKITGVDASIIYPAVQWTATLDKGDLTLAIPALRVKGKPDELGKQWLEKWPDSPLVETPNQVGPFIQFFFKTGPLTKTVIPMALSHSSTFGANPALGLKDQSDPSKGRKRIVLEYSSPNIAKPFHAGHLRSTIIGGFLSNLYRAAGWDVIAINYLGDWGKQYGVLALGFEKYGSEAELEQDPINHLFQVYVKISKDVADEKEAAEKLKAEGKEAEAQKILDDGLDEQARKYFKKMTEGDEKALALWRRFRDFSIERYTQTYARLNIHFDEYSGESKVSEDDMHAAAEKMKEIGLAEEHEGALLVDFVKNVPGKEGKQLGKAILRKKDGTALYLTRDISELLNRAKKYNFDQMIYIIASAQDLHVKQFFKIVDMMGHKDIAARCQHISFGLVQGMSTRKGTVKFLDDILRDVGDHMHEVMKKNEDKYSQVDDPVKTADILGISSVMVQDMLGKRYDSSETGDFAGALADHRDRVNGYKFDLQRMTSFEGDTGPYLQYAHARLCSITRKAGLSEEEIASADLSLLTEPMAVNLVRVVSQWPDVVQNTVKTLEPTTILTYLFKMTHTLSTSYTHLRIVGSETEVMKARMALYDAARIVLSNGMRLLGLSPLERM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LS54</accession>
    <name>A0A367LS54_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_1844</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LS54"/>
    <dbReference type="OrthoDB" id="5329176at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="42"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI17190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="340" mass="37594" checksum="70053D08808E353F" modified="2018-11-07" version="1">MAGAQPKQINFDPNLPDENRGQGILVLCTVFSVLIVLSTTSRVVIRFTSHGLGATDYFNVITLAFNLATNILDVQSVHEGLGRHLQYLTREQGLHLKKMNQITMLLANIALWAVKMSVCFFLLALTNKAHRRVRCIVLGLMVLTTSGSLSYCIVWGIQARPLERLWTPDMSGEVMDPHILTIAVVVITDGPEGKLTVMALTGSGLLVFAFSIARIGFYRDFLAPDYSWAVYWIWMCTITERNLAEIVADLPASYTFFRDLGRKAHNMKGPSHADRMTATSALHQPTCSNAYSTYPEDVIPLKSPSGKGGAIHLRTSIDIEARSVDAKEEEHPGRMQTSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LSF7</accession>
    <name>A0A367LSF7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_1699</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LSF7"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI17373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="85" mass="9813" checksum="87B8EC454FA8FED7" modified="2018-11-07" version="1">MQYERLLFDFYVETGGSRFARGLANFVSIDTPGLPLSKVVKLSKVPKTNAPPKRRIELEDKYSQYAFSNRQLLDIIRSGYRDRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LSI8</accession>
    <name>A0A367LSI8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_1693</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LSI8"/>
    <dbReference type="STRING" id="1330021.A0A367LSI8"/>
    <dbReference type="OrthoDB" id="2649at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14136">
        <property type="entry name" value="STKc_SRPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000409">
        <property type="entry name" value="CMGC/SRPK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000076">
        <property type="entry name" value="CMGC/SRPK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="45"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="202"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="220"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="288"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="74"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI17381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="512" mass="56882" checksum="3AAF186EDE42CC1E" modified="2018-11-07" version="1">MAPSPSPSSADDPAENTADEEDSEDYCKGGYHPVQVGEKFKDGKYTVVRKLGWGHFSTVWLSRDNSNSKHVALKVVRSAAHYTETAIDEIKLLSKIVQAKPDHPGRKHVVSLLDSFDHKGPNGTHVCMVFEVLGENLLGLIKRWNHRGIPMPLVKQITKQVLLGLDYLHRECGIIHTDLKPENVLIEIGDVEQIVKKVVKNDAGDKENNRNGRRRRRTLITGSQPLPSPLNSSFNQSNLFPSPGSQPNLAGVLGEAASASSKESSLKSPDESQKQREKSADVLSREVSGISLDKSSSSSVLTGEKRKAEDSHPFDIISVKIADLGNACWVNHHFTNDIQTRQYRSPEVILGSKWGASTDVWSMAAMVFELTTGDYLFDPQSGTKYGKDDDHIAQIIELLGPFPRSLCLSGKWSQEIFNRKGELRNIHRLRHWALPDVLREKYHFKEEEAKRISNFLVPMLELVPEKRANAGGMAGHGWLDDTPGMKGLRIDGLEVGGRGEGIDGWATEVRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KYW3</accession>
    <name>A0A367KYW3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_3772</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000034">
        <property type="protein sequence ID" value="RCI07364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KYW3"/>
    <dbReference type="OrthoDB" id="3798971at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI07364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="43" mass="4719" checksum="C69C28BE1D0E343F" modified="2018-11-07" version="1" fragment="single">CPEYNILAKAGSSLGHLFSEETKVKMSLADVLDQKDPEVQLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZ90</accession>
    <name>A0A367KZ90_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Cytochrome P450 monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_4531</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000028">
        <property type="protein sequence ID" value="RCI07490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZ90"/>
    <dbReference type="STRING" id="1330021.A0A367KZ90"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF5">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI07490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="543" mass="61898" checksum="1B0577D64ADF7E1A" modified="2018-11-07" version="1">MLKELTWTNLHTTAAAAIILAFLFFIRHLDYDKTVRSSIPLTGSETKPQLTTKIKVNVPVVGPLASFTKWVAAIRNYSKSAFQIPTMTRMDVFLCDRAMTREYYSLDEEHMSFQAAMSEEFQFRYSLPGQQHDIRKIPNSVIGKALSWQRNRSNNAQDPFFADFSKEFLHGFLQEMDGYRRKQSSSRSLPFFSHAADPSPEWIAMPCFSLSMKIVARLTTKSLFGEPLCRDDDFLDLCCQFADAVPRVAMVLRCFPAFLRPFIAKHLAGTRLVQKLRTFVLGEVLSRRNSRSNNPMKDLLDFVINWADEQEYDWSDLEVSDMIINVVFAALHTSSQLVTHTIFELATRPEYVPLLREEIQHCFETYGEGTKAAVDAMHNMDSFIKETQRCNVLDAAALARLVLKPYTFSNGLHVPEGTYIFTPNSPLLQDERFYKDPDRFDGLRFARMRNDVKLRASCPLTATSEHSMHFGIGRNACPGRFMVSDEVKLVMIHLLLNMELAMENFGPRPGNVAFGKFMLPDMKAKIWLKKASALAVPRAGTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZC3</accession>
    <name>A0A367KZC3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_8324</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000027">
        <property type="protein sequence ID" value="RCI07525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZC3"/>
    <dbReference type="STRING" id="1330021.A0A367KZC3"/>
    <dbReference type="OrthoDB" id="3594036at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024937">
        <property type="entry name" value="Domain_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051083">
        <property type="entry name" value="GrpII_Intron_Splice-Mob/Def"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34047">
        <property type="entry name" value="NUCLEAR INTRON MATURASE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34047:SF8">
        <property type="entry name" value="PROTEIN YKFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01348">
        <property type="entry name" value="Intron_maturas2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI07525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="210" mass="23874" checksum="8DEF9319E3E3E503" modified="2018-11-07" version="1">MILESIFEPSFLSNMNHRRRYLAVLPAGYLEFKVYQHSLIGGDEVPQGSIISPILSNIYLHELDKYVIKLTKEFETGIRGSMADCRSILEKVTKYLKHELMLEVSVSKTKITNLNNDRAIFLGFNICRAKQDTFDEIILLYNSVYRGIMQYYSFVNNKNVLSARMYLILKSSCAKLLASKFTLGTQAAVFKKFGKNLKGSNKAAFSPIST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZD7</accession>
    <name>A0A367KZD7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein L34e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_1660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000026">
        <property type="protein sequence ID" value="RCI07538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZD7"/>
    <dbReference type="STRING" id="1330021.A0A367KZD7"/>
    <dbReference type="OrthoDB" id="277449at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008195">
        <property type="entry name" value="Ribosomal_eL34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038562">
        <property type="entry name" value="Ribosomal_eL34_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46595">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01199">
        <property type="entry name" value="Ribosomal_L34e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01250">
        <property type="entry name" value="RIBOSOMALL34"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI07538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="22350" checksum="1C50D174D92750BD" modified="2018-11-07" version="1">MDVMESKPPADDQALCDAQSLEEEQLKMAMKRLKLLHIKARNLRDIIPRIIEPLVQMHPSPDVMFHAFMKAVNDTQAEIKEFTELMKDEESMQVFAQANKSREENPFGGHLRLLHIKKRGTVPKCGDCGAKLSGIPALRPREYANISKPQKTVQRAYGGSRCGGCVRDRIVRAFLIEEQKIVKKVLKEQEQSQKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZL5</accession>
    <name>A0A367KZL5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">rhomboid protease</fullName>
            <ecNumber evidence="4">3.4.21.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_1650</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="4"/>
    <dbReference type="EMBL" id="LKCN02000026">
        <property type="protein sequence ID" value="RCI07611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZL5"/>
    <dbReference type="STRING" id="1330021.A0A367KZL5"/>
    <dbReference type="OrthoDB" id="10257275at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066:SF1">
        <property type="entry name" value="RHOMBOID PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43066">
        <property type="entry name" value="RHOMBOID-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="11">
        <location>
            <begin position="55"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI07611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="263" mass="28689" checksum="8912955C011DFD09" modified="2018-11-07" version="1">MPGTRGFGAARLRSLPLFTRALIVVIIIVWAAGLPSAWNVRDWAALVPNKVSLKKAYRLSTFPLVHLNAVHAVLNVAALTPLMERFENEHGTLTTLSLFFGPLTTLPATLYLVIERGILRSNNAVVGASIWVFLLLGVEAIRTYRSDPHLVIGAYQVPTWITPLLMIFVVAVLIPNTSLLGHLCGTFVGYIFGLGYLKFLAPPERALRWIEARLNLLAVLPHYVSVDQKTYGRFGVLPSSNGSGSAVTEIVGGNQRLGLRATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZN4</accession>
    <name>A0A367KZN4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 17">Alkaline phosphatase</fullName>
            <ecNumber evidence="3 17">3.1.3.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">L249_1674</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14">Binds 1 Mg(2+) ion.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="14">Binds 2 Zn(2+) ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the alkaline phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.1" evidence="3 17"/>
    <dbReference type="EMBL" id="LKCN02000026">
        <property type="protein sequence ID" value="RCI07624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367KZN4"/>
    <dbReference type="OrthoDB" id="4095816at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004035">
        <property type="term" value="F:alkaline phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16012">
        <property type="entry name" value="ALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000063">
        <property type="entry name" value="Alkaline phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001952">
        <property type="entry name" value="Alkaline_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018299">
        <property type="entry name" value="Alkaline_phosphatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051726">
        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF2">
        <property type="entry name" value="CHITIN SYNTHASE REGULATORY FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00245">
        <property type="entry name" value="Alk_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00113">
        <property type="entry name" value="ALKPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00098">
        <property type="entry name" value="alkPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00123">
        <property type="entry name" value="ALKALINE_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 14 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="15" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="9 14 17" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="809"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="844"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="875"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="911"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1016"/>
            <end position="1035"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1042"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1068"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1101"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1129"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="1217"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="15">
        <location>
            <begin position="239"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="25"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="468"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1705"/>
            <end position="1733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="489"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="537"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="560"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="659"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="709"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1705"/>
            <end position="1722"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="13">
        <location>
            <position position="1306"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="1258"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="1258"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="1357"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="1359"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="1501"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="1506"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="1510"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="1549"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="1550"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="1657"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR601952-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU003946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RCI07624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1733" mass="189411" checksum="97ECAF8B6C207BB8" modified="2018-11-07" version="1">MPQLSATFVPGGLDDYYLPEVVAPSPQRVTPQIPQTMQDDLQRLELGDGQSSEGASRRGRDSPSSTRNDSRPPGRAPEPRSTSSGDADADAIIYQNSPQLDNMDADAPSFSPFPKVTGDNIPPADDAKEGILWNARKHVLHSQNVSMQMSWARDALVWVEIAADAAAREPPEKARPSTPRIEHELREDALNIVNYLARQEYPDALYVRAKWLEFGKFGTRVDKREAYNGYKRAADLGHPRSEYRLGMLFEQSNDMSKAKEHYYKGMSLKDSASLYRMGMMSLLGQHGESKDYPRGLERIQAAADSSDEDAPQGSYVYGMLVGRDLPDISIADGLLPYNLETAKMYVEKAAYLGFAKAQLKMGQAYELCQLGCEFHPSYSLHYYGLAARQGLPEAALGVSRWFLFGYEGVFKKNEELAFKYAQEAATAKLPTGEFAMGYYYEIGIHVNKSINDARKWYQLAAEHGNKDAQNRLDSLNQDKSLSKTDHETTTLTRIKSQHGSQRGKRPERFKQAQHMPTLKESGSSPTLDNEARKPSIVASSATNSPRLSPQVSPGIRPTMMSESTSVPDPSRVSTVGADRQSAFNIRPDIASRPRSAAPYPEDGRPLPNRSRSTAPYPEDDVAGGPNLYHNMGPHSSYADRPISSFSGKGPATGPRPMPTSHSVGSLQPQPMPPSQGRIASAGYNRASPVGHRHQSPGPHNAGGRPYPSDYSQGRPPSTQPNPSGHRMQKQNDARMPGQGQERLSRVPGATGRPERLVCCLYVCSYLDRGNIGNAKTAGAQDALGLDSTQWAWVLNSFYACYVLFEWTTMLWRILPASIFVSLLCLCWGAAAMSSGAARNMGELIVTRCLLGVFEAVFGSGAPYFLSLLYKRRELALRMSILLGMMPLANTFASSLAYGITQMRGSIEPWRLLFIIEGSFSIVLAPFIYLYLIDSPVTARFLTAEEQVVAVERLQLRDSTARRGVRWRQVLAGVRDYKTYVHAGIHFCANYSFAALSNFLPTIVHDMGHDPVSAQGLTAPAYFAAFLLCVVTSYLSDRTGWRGVMLAGSAAVAVVGYGLLVGFRDAGARYVGVWLAACGSFPALSLNVTWQLNNQGGDSKRGAGLAVFLTLGQCSSFVSSAVFPTSDAPFYVRGCAVGCGLTGLMLVLALGMHFALEAENRRRDRVYGPVDAEGEVDVTEAGDDHADFRYVTPLLEDETQDDDSKPKNAHRWQRVREIVLFVWALIATAAVIIIAVWTQHSQQTSGRSAKRNLVFMVSDGMGPASLSLTRSYRQLVQKLPHDDILVLDKHLAGSSRTRSSNSLVTDSAAGATAFSCGKKSYNGAISMLPDLQPCGSVLEAAKRAGYMTGLVVTTDITDATPACFASHVQLRGMQDEIALQEIGQGPLGRTVDLMLGGGRCHFLPNSTSGSCRGDDVDVVRLAQEKHDWTYIADRHGFDSLKRADGVKLPLLGLFAPSDVPFEMDRRRMNDIYPSLSEMAETALRILEKATADSDKGFFLMIEGSRIDHAGHFNDPAAQVREVLEYDKTFGIAQAFIDNSKADGVLVGTSDHETGGLSLALQEPGHLPVYNWFPHVLANASRSSERLAADLQRHIASSTLSRDDLKAWINSELVLAGLGIADASDDELSLLADNPDASLTIFSAIISLRAHVGWSTHGHSAVDVNIYASPGPDTDPLRGNVENTEVGRFLSDYLDVDVDAITRELRRETKARPQDQARSHKAPEAADELYASDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZS7</accession>
    <name>A0A367KZS7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_5903</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000025">
        <property type="protein sequence ID" value="RCI07664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZS7"/>
    <dbReference type="STRING" id="1330021.A0A367KZS7"/>
    <dbReference type="OrthoDB" id="10264544at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24162">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013881">
        <property type="entry name" value="Pre-mRNA_splic_Prp3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027104">
        <property type="entry name" value="Prp3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010541">
        <property type="entry name" value="Prp3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14212">
        <property type="entry name" value="U4/U6-ASSOCIATED RNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14212:SF0">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08572">
        <property type="entry name" value="PRP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06544">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor 3" evidence="7">
        <location>
            <begin position="107"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Small nuclear ribonucleoprotein Prp3 C-terminal" evidence="6">
        <location>
            <begin position="346"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="39"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="309"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI07664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="487" mass="54807" checksum="614CD99EE643BDF5" modified="2018-11-07" version="1">MDSRPPGLGPQPDSASRIQKAVPATDKKAALKARVAAAIGTSKSKGGLNVGLHPALEDLGSWKPQVKIGDSSKTHNFSQPKPASTRGVHNAKPAGTGRLDDNREHSNPYYDETAATPSNGHRGRDPKRLLFNQKGKYIQQAGALRRQADLEAMKKRIAEQTRKAGIEDDLDVEKNFMPETPPDVEWWDEGLLDGRTYAEIGTLSKVKSGTPDSIVTEYIQHPVALEPPQDRHRTPAKPMFLTSKEQAKLRRQRRKAELKELQAKIRLGLIPALPPKVKKGNLMRVLGDVAVKDPTAVEARVNREIEERHQKHIQSNEERRLTKEQKHEKLAKNQQNDATKGIYILVFRITTLVNGQHRYKIGVNAEQLDLTGICIMHPKHNLVIVEGGAWSTNKYKKLMLQRIDWTENSPTRRPENGQNSGRDWLQAESDGLLKDMSSNECKLIFEGEQKARAFRKWGSKICETDTQAREMLARVKMDNFWTLAKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L029</accession>
    <name>A0A367L029_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_5700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000024">
        <property type="protein sequence ID" value="RCI07776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L029"/>
    <dbReference type="STRING" id="1330021.A0A367L029"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF7">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016671579" description="DUF1996 domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="3">
        <location>
            <begin position="33"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI07776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="483" mass="52815" checksum="CCF2D72D7F101BC2" modified="2018-11-07" version="1">MIKSITLSAAFIAGANAFWRMECPGRVGLARIDPIVNPDEVSNHVHSIGGSSAFSENSSYADLTHGKCTSCRVKQDMSSYWHPALYFKDASTGKFEVVEQVGGMLAYYLLNGDHITAFPPGFRMLSGNTNRTEYTLGDPSHPDPDKSAWASMGQTSQKDLAQRAVGFNCLNYGKAPEGTLFRHFLPDKQYLDANCKDGVRFEIMFPSCWKGGDAVDSPNHQDHVAFPDLVMTGTCPESHPKRLPGLLYEVIWNTAGFQDRQGKFVLSNGDSTGYGYHGDFMMGWDEAFLQKAVDTCTNPSGRIEDCPLFDIIDKSEACQCSLESLPPSVQDEDVKGPMARLPGGRDNHESNEKPGYAAPVPTLKYTPGHKPTDPAAPLPGDVFKQKQHAEAEAMKMNAEQAPAPAQTPPPAATTPAADAKSYYSTQYITNGNVVSKILLEAQTVYVSQYADQAAATPAATPDAAAHRRRAVHMYQHAHFRRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0K2</accession>
    <name>A0A367L0K2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL6 alpha-beta domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_5846</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000023">
        <property type="protein sequence ID" value="RCI07941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0K2"/>
    <dbReference type="STRING" id="1330021.A0A367L0K2"/>
    <dbReference type="OrthoDB" id="10252633at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000003">
        <property type="entry name" value="60S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000004">
        <property type="entry name" value="60S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002359">
        <property type="entry name" value="Ribosomal_uL6_CS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF16">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00700">
        <property type="entry name" value="RIBOSOMAL_L6_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="4">
        <location>
            <begin position="12"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="4">
        <location>
            <begin position="97"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI07941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="192" mass="21882" checksum="2EBF218655A5FA68" modified="2018-11-07" version="1">MKYIHSYELLEIPEGVKVSIKSRVVTVEGPRGKLVKDLSHLSVNFGHPKKNTISIEIHHGSRKDVATLRTVRSIIHNLVVGVTKGFKYKMRYVYAHFPINVNLDKNKETGLWEVEIRNFIGEKIVRRVKMQEGVDVEISKSQKDELVLSGNSLENVSQSAADIQQICKVRNKDIRKFLDGLYVSEKGNIIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L124</accession>
    <name>A0A367L124_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_6259</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L124"/>
    <dbReference type="STRING" id="1330021.A0A367L124"/>
    <dbReference type="OrthoDB" id="3248508at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06503">
        <property type="entry name" value="ATP-synt_Fo_b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842:SF3">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="56"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI08097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="619" mass="68566" checksum="461FF1A84216443A" modified="2018-11-07" version="1">MAAPPPLAPHPRRSSSSSSDHLLPTPAGSDPRSRSTQSLAPDSEAYDGPRRRLLLLVYLHGFYGNAQSFRSFPAHVHALVRRLLADSHVVHTKIYPRYKTYRAIDVARDNLSAWLEPHESPDTDVVLVGHSMGGLLAAEVALMTADKRVDPPKPGRHKDAFKHRILGTLSLDSPFLGLHPRIVAAGFSSLFRPAENTDGEAEPSPAPPETDPCYDPPYWNDEPLKEQPFLNRIMHFTSKHRSDGLFNALRNHIASHLEFGGCLADYPGLVSRYDRLRALEDVDETRDGSARVRFVNYYTLCSGRPKAPKNDAEVGAGLLDVPADSVEVPHDVDTWVESDGQDEAVEEQQPVRNSPAPQNAAALLLTCPPPSSSSTKSRESRADGLGDEGDGGLDEYDDDDDDDDDDDDADLVPIPDEPTKPEAPDPQQFAEGAARKKAEKDAKRAQRSYGEAVKERDKAIRRRDKQLEQRRKEARREADKQQREAQKAMRRREKEAAREADKKDKAKNKDKKKKEEEARRREAEMTPSPRGSRKFCALPWRRRLASSAPAFSSSSSLDGDGDATWVDVYLEGVDEVGAHCGLFVASAAHYDALVGDVGSRVADWVNEYLSARAVLGDWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L163</accession>
    <name>A0A367L163_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_6339</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L163"/>
    <dbReference type="STRING" id="1330021.A0A367L163"/>
    <dbReference type="OrthoDB" id="4930473at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI08137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="122" mass="14061" checksum="F371CC409470A387" modified="2018-11-07" version="1" fragment="single">TRYKDIKTFSRKKGEFSAFLTNLKDKIRTDKAIFRDEEDRIGFLFRSLEGKARKTLETRLLTKTKDDSLSYEDFCGYVKDSAVKRLDAELVLPNDLPALAKYSLSILLPKTPLLNRQIDLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L184</accession>
    <name>A0A367L184_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_6329</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L184"/>
    <dbReference type="STRING" id="1330021.A0A367L184"/>
    <dbReference type="OrthoDB" id="10255013at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15849">
        <property type="entry name" value="SNARE_Sso1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF307">
        <property type="entry name" value="PROTEIN SSO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00804">
        <property type="entry name" value="Syntaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00503">
        <property type="entry name" value="SynN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="8">
        <location>
            <begin position="201"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="239"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI08185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="307" mass="34772" checksum="86960050B60A5138" modified="2018-11-07" version="1">MSTGGGYGYGYGANNPYAEDQYEMTDYGHPDKPLTHTTTVLSQQAFLERVQSLRDDIRQLTTEVDHIGQLHHRCLSSADGLAKSELEQAVIQTQIRNTAVKDGIKGLERDLGRTTDTSRATKKTQLQSLKTFFRSELDKYQAIERDYRGRYREQIARQYRIVNPEADEEEVRQAAEADWGNEGVFQTALRTNRTGHATSLLGNVRARHNELQRIEQTLTEIAILYDELATLVEQQDPVIQSAEENAQHTVDNMEKGNEQVQKANEHARRRRKLKWWCLLIVVLIIIAIGLGVGLGICFGTGVDRCSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1H9</accession>
    <name>A0A367L1H9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7821</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000022">
        <property type="protein sequence ID" value="RCI08072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1H9"/>
    <dbReference type="STRING" id="1330021.A0A367L1H9"/>
    <dbReference type="OrthoDB" id="3366823at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053007">
        <property type="entry name" value="CYP450_monoxygenase_sec-met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47582">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47582:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="593"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="630"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="784" mass="86310" checksum="BBF4374D8F7299B7" modified="2018-11-07" version="1">MAVQSICSGLFDEAVLSFELHLVLILFALFSLFTFSRRVFSQAGDLLPSSPRRQGKFWPEQIPHVSSTIPWIGHAMELRRRGARYIHQLILNAPAPVFSINLLSRKVLVVHPSLERALARHVDDTSLARIISLIGQRSLGLSESGVDVIGAYNPRPVHAQLFAAADGSARLAEQSARFVREHSLRQPGEQRVLIGRWLFDAVVGATAHALWGERNPWNEDSEFMRQFIILSDGLESLSQPLPQLTARAPYRARSFLLKRLMAFHRQHRQSRMTSVAHRINAVAMTDANWEDNDDYYRCELLEALGLLATASTLSVWLVRHVLADDGLRRRVVDEVRSLPPDLADLKKTCPHLVAAWYETLRLHVTAVPRVATGDIDLGGASVSEGDVLIMPMLSFNINPKTWGADAEVFRAERFLDEKRQLLTALTRKVHGFGVAGNLCPGRLFGFDTAMSSVATLLRDFDVFTSSGSAPLPRSRGGIAVGFERLGDDVELVQSRDWPRDLRGDNRRQNASIFFSPSSITTFFQFDDAAFQPRLFPDFEAEGPPPGEAWVDVTASSSLPIGVDEDESVNDDVDAGTPLPARVVIFHAGTVRTVFLALVRLSSLLVAVFFVLLIAPAYVRADKDVTSTAAIVVGGIVPLVLITLSTSSFVTHIYMHLPDAARTSRHALARYVESLPASTPLTLTTMNALAIPRYTRLQAVDLRPATDSILSRLGLVNYVRRGADPGWFRGAKSFFVQPRPPMSPVAADAPRSDAVESWIWTTVQKRIATRAAATSSSSSPSSPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1K1</accession>
    <name>A0A367L1K1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_8360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000020">
        <property type="protein sequence ID" value="RCI08277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1K1"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI08277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="101" mass="11646" checksum="F0E5346A6CF5B2F7" modified="2018-11-07" version="1" fragment="single">RPIDSSQRSSQRSARCTYSGHSTRLISAQGSRYIDRRAVLIAVIALDQSSQRLSHQIVRLIYDVKVFLQITYLPTLTSLLLYYNHLSCLQFFFNPHKTTIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1S7</accession>
    <name>A0A367L1S7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">VASt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_8898</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YSP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1S7"/>
    <dbReference type="STRING" id="1330021.A0A367L1S7"/>
    <dbReference type="OrthoDB" id="2162691at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140268">
        <property type="term" value="C:endoplasmic reticulum-plasma membrane contact site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120015">
        <property type="term" value="F:sterol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032366">
        <property type="term" value="P:intracellular sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13220">
        <property type="entry name" value="PH-GRAM_GRAMDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051482">
        <property type="entry name" value="Cholesterol_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004182">
        <property type="entry name" value="GRAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031968">
        <property type="entry name" value="VASt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23319:SF4">
        <property type="entry name" value="GRAM DOMAIN CONTAINING 1B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02893">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16016">
        <property type="entry name" value="VASt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00568">
        <property type="entry name" value="GRAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51778">
        <property type="entry name" value="VAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="945"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="domain" description="VASt" evidence="9">
        <location>
            <begin position="714"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="14"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="115"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="165"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="266"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="579"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="884"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1021"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="321"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="338"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="404"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="588"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="611"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="896"/>
            <end position="906"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI08399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1073" mass="114961" checksum="05FFE77CB32DD618" modified="2018-11-07" version="1">MDGLGKLLPKAISTVKRKTRRHKAVNDSSSLAPPSTSDGVDGDTCLSAWPSRSDQDDGSCDASLEQVEHDQPQRPASDTTPPAARRPAPISAHPSQLGYLTTSSPEVQANHLSLQSLPQPPSTTAPGDDVALDPALEPPTAAPNPTPLTLDIHLARALAATDKATTPLIVSTPPTPLEPSAVVGDRRPQTSNGVSPQSISYGNDSDQSMNAPWRNKSSVYAATVPSKLSNTVLPTPEPIAESGQTTPSGGFFSSVISAAQTAANTLSNNIPGGGNKSRTSLARSSAPSTSARTTETEPSFASQRSSDLSMDSRKESTVQTLGSGDLSLSHLGIAEPTGPAPPPAAAKPPEPVDLRFRSDSAPADSHLRGQESFQDESFSRPHSLAEASAGEPLPSSHAEADGKSSIARAASTRSAQYKPQKKRRGSANAGRLRAAALGSIVQSTTGFVTPKLTGFAIASKKRNRDFHSLFKSVPDDDFLIEDYSCALQREILAHGRLYVSEGHLCFSSNILGWTTTLVMSFDEIVSVEKRSTALVFRNGLMISTLHAKHVFASFTSRDATYDLIVNIWKLGHPTLKSTLNGVRLDGTGGDKTEKVDAEPSMQEHETQAASDLDDDSDDDDDEEDDDDDDDDDDDDDDFYDEGHEYAVDTQATELTSPDAETETTAGRKVSGMTTATGGAADVSREAPSSPGGSADFPGPTTHPPTDCGDSATHYDKVVADEVIAAPLGKVFSLVFGSGSVEWMTKWLTGDQKCFDLQMEDKTGLGPDTRVRNYTYIKPLNASIGPKQTKCIVAETVENFDVDKAVNLNVTTQTPDVPSGNVFTVKTKYCLSWADNNSTRMQVNCMTEWTGKSWLKGPIEKGVGDGQVQYCKDLFAALRAATSARPRPGAAAGHGPGRARKKAKKSKALQAADGGAEKSGGSETTKRSDWGPLEPVRGLVEPCMELVGPVLTGNVMYGLLVGLLVAMWFGYGSTPTKSTGPYGGDMLYGHGRLAMYEDMWRREESELWEWLDERAGLDRLNSEKAEKRRHNLEDKLREGQMNEREMKEAIRVTEEKLKVLRELAEKSDRGRGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2G1</accession>
    <name>A0A367L2G1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mediator of RNA polymerase II transcription subunit 31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_4719</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Mediator complex subunit 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2G1"/>
    <dbReference type="STRING" id="1330021.A0A367L2G1"/>
    <dbReference type="OrthoDB" id="10257739at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1340:FF:000002">
        <property type="entry name" value="Mediator of RNA polymerase II transcription subunit 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1340">
        <property type="entry name" value="Mediator of RNA polymerase II, submodule Med31 (Soh1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038089">
        <property type="entry name" value="Med31_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008831">
        <property type="entry name" value="Mediator_Med31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13186">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05669">
        <property type="entry name" value="Med31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0010">Activator</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI08620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="124" mass="14393" checksum="15A1E759CEB3F546" modified="2018-11-07" version="1">MASPPPPPPPQPPADEGEEPLYGGYSRFEMELEFVQSLANPFYLNHLASQKLLSQPAFVAYLAYLQYWASPPYVKYLIYPGPTLRNLELLQQERFRQDIMSPELVQRLVEEEMKAAVQWHREGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2Z4</accession>
    <name>A0A367L2Z4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_4893</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2Z4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI08778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="204" mass="23613" checksum="CE4B80A61B4D10A7" modified="2018-11-07" version="1" fragment="single">VWSDKFKVDEDDNDGVWRREWLEVDVLLYGPGDGAEGCSYMDLDTKERPRGWVSLEDKSSRSSSLSEIQNQTIHHGHGYSLVEWKYIWNNMTNPQSMKFAFLGERIASGAWDWSRPEHVSSDGFQGGRPSRETIEKKAHSQADADKVPSFVMVFPFFFFPLRLLLSFTGDEGRERLRKEKNINKVSWMKGGVELQDEMWMDPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3E6</accession>
    <name>A0A367L3E6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI08953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3E6"/>
    <dbReference type="OrthoDB" id="4755921at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="426" mass="46978" checksum="11FD1BB74FF3F301" modified="2018-11-07" version="1">MDEQRLPAKLLEALKNPNWRQRRSSSSSSNAGCEMTGYDGSKSRSRHTSSSDFVMVEPDNINNRKISATDRQFNTRSHTPARAVRSLDDDDQVCRVIRHATLDTSRYSEPNGPQLFEMTARDPEQPLDYNMPLAVMRPLKPCPPPMLEPPVVEAVLEMAEPDQTRSTTRLPSNKDAAFRRLLDKLNRSAATTAATRSREANDSGYGTAAGSDEQGTQMPAPPPTSDQLVLQMLVDAGGRRAGRELTVSDSPLNYYRPPELNVADEGVKFRHDLNPKAREFLSFVREAAMEQQSSATKTAVPDGANCVTPKQNATACNPVPVPMPVLYPLTLPQVPEMSAMQLAPFLGVANAAVMEAAAMAAVAARAPLFPCPKPAQAYEAYIEQRKAMEPGYAMECRLRQQRRAKRAHQGRVQYSATQLLMLRSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L454</accession>
    <name>A0A367L454_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_4993</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI08992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L454"/>
    <dbReference type="STRING" id="1330021.A0A367L454"/>
    <dbReference type="OrthoDB" id="5982228at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000025">
        <property type="entry name" value="High-affinity methionine permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF498">
        <property type="entry name" value="HIGH-AFFINITY METHIONINE PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="470"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI08992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="527" mass="57767" checksum="2AD3B11619A1CA4B" modified="2018-11-07" version="1">MEHVSESGREEGDDAVVVKGCYDSTSTSLDTDLGRLETARENKRQIGIFSASLLIFNRTIGTAIFATPATILSLSGSVGLSLLLWLVGMLIALAGTAVYMELGTGLPRNGGEKNYLEHVYRKPRFLTTSLYTGYVLLLGWAAGNSVIFGEYVLHAARVEPGRWNQRAIALGCLTLAFLLHGLALRCGILLQNALGILKIGVIIIIIVAPLFNLGQVRANTNFTGHIFQGTTASPYGIVTALYSVIWSFVGYSNANYALSETRNPTYTLKWAAPLGIGTISVLYMLANVSYFAAVSKEDIIQSKRLVAASLFRNVFGEPAERALSVFVALSALGNVMSVLFSQGRLVQELGREGILPFSRLWASNRPFNAPLAGLFQHWLVTSITVIAPPAGDAYNFVLNLISYPLAIINVFVAGALIHLYRNRHTWKWNPPLKASLPVVFFFLLSNIYLVVAPFIPPDGDSQGVYQSLPYWIHCVVGFAVLFAGGLYWLVWAVIMPKLGRYELVQETVVDPLDGWERNVFTKRPLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L484</accession>
    <name>A0A367L484_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L484"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="197" mass="21676" checksum="C179A4198EED1A64" modified="2018-11-07" version="1">MVSRLATREFPHLDGWHFPTSRHSRSSSLFIYSIFGLSSPDGEAFQDNAVLTPLNAVASRRSMLSTRPLNSGGWYIDTSLSKTSSSDNQPLVATRESESETNGSSLPTRQKANPSIPRNWRGGNPGLMSSSQSHRFQFPLLGTTLGTVMVLPLVECCRWQETALLCGFSCDLLYPLYFDPAIQVGAFFSTLGSHLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4A6</accession>
    <name>A0A367L4A6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_1516</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4A6"/>
    <dbReference type="STRING" id="1330021.A0A367L4A6"/>
    <dbReference type="OrthoDB" id="5411533at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000495">
        <property type="entry name" value="Putative G-patch DNA repair protein (Drt111)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040052">
        <property type="entry name" value="RBM17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288:SF8">
        <property type="entry name" value="SPLICING FACTOR 45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13288">
        <property type="entry name" value="SPLICING FACTOR 45 SPF45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="339"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI09265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="508" mass="55903" checksum="CFAFFD1B39C72C9B" modified="2018-11-07" version="1">MPSPPPPPPPPPQPQGGLSLYSNIHDPDDPNPTATISAAPVRYDATEPKKSIIDSALRFQPQIRRPPVKQAKSKATFPKGIIQKAAPASADAPPAAAPKTTTLADWTAMEEDDLTYGTGERPQRGGRKRRRKKKQREEPTDINWDEYYDPGKPTNVEHYLVSDEKINEVLDWKAVLYRHRKRQFNSDSPSDDDDDDDDDDDDDGAGLVPQNQFAPPPPPPPHEFAPPPPPPPTKTVTEEQASEETPRPRMEISLSPPPPAMDAPPLPPPPPPPPAAQERKPSSPAPSSSAVISRQPVMYNNTKPTTETSTKDKEEDDIDASAKQDPTDTNTPRSKRPGQAGFAHRLMSKYGWTKGTGLGANESGIVNPLRVQVEKRKKKADADGGGWAEPSKKARILGGGQRKEDKGKFGKMSEVIVLDNMLENMDDLRGEISEGLGQEIGEECGEKYGRVERLFIDEEARRVFIKFTDQVSALRAVNELEGRVFNGNSIAPKFYDAEEFEQGIYTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4F4</accession>
    <name>A0A367L4F4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1476</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4F4"/>
    <dbReference type="STRING" id="1330021.A0A367L4F4"/>
    <dbReference type="OrthoDB" id="40334at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02970">
        <property type="entry name" value="PRX_like2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000404">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032801">
        <property type="entry name" value="PXL2A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28630:SF3">
        <property type="entry name" value="PEROXIREDOXIN-LIKE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13911">
        <property type="entry name" value="AhpC-TSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="27437" checksum="9A70291289BD530B" modified="2018-11-07" version="1">MGDDKVNTAEPDSNIDDLPSDEAIRRTEKYVLLDRHGRTHTFLSLYSGHNVARRVLVVFVRHFFCGNCQEFLRSLSDAVTPDALLALPTSTFIVVIGCGDPALIQMYADATGCRFPIYTDPKGSLYDELGMVKTLALGDRPAYMRKSMTKGIVDSIGQALRSVPSGLALKSGDHRQVGGEFLFVPFKDRVGTPTTEEGGEDKEEVEEERKRVSWCHRMRTTRDHAEIAEIIDVLGLGKDAAEEDGSTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4W5</accession>
    <name>A0A367L4W5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_3792</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4W5"/>
    <dbReference type="STRING" id="1330021.A0A367L4W5"/>
    <dbReference type="OrthoDB" id="983479at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048205">
        <property type="term" value="P:COPI coating of Golgi vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08831">
        <property type="entry name" value="ArfGap_ArfGap2_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000013">
        <property type="entry name" value="Putative Arf GTPase-activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686:SF4">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="11"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="139"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="281"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="345"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="139"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI09483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="484" mass="50943" checksum="D2708E7E2C9CA265" modified="2018-11-07" version="1">MSGLATKQQSLKIFEKLKSKPANKICFDCSQKNPTWTSVPLGIYLCLDCSSNHRNLGVHISFVRSTNLDQWQWDQLRLMKVGGNESATKFFQQNGGTAALNSKDPKTKYQSNAATKYKDELKRRAARDAKEFPGEVVVTESAEADTASAAAGDDDDDFFSSWDKPAIKRPTPPLSRTATPPVVGRTPSPFLNAGNGAGKDLARSTSPLGKTDDGKPAASRITTSAALRKNAGSATGAARKTNVLGAKKTSKLGAKKVTADVIDFDEAEKKAKEEADRIAKLGYDPEAEEEQTIKAASSGTGAASILSPSPVSPPRGGGASGQKSSADVERLGMGVARLGFGQIGGSKAAPAPTSKKNAGGFGSVGPVKATAQDESENYARSKFGNQKGISSDEYFGKGAFDPNAQAEAKTRLQGFEGATSISSNAYFGRPEDEAEEDYGDLESAAKDFVRKFGITASDDLENLGNVLGEGATRLQGAIRAYLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5B4</accession>
    <name>A0A367L5B4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_4004</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5B4"/>
    <dbReference type="OrthoDB" id="4160064at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI09614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="187" mass="19411" checksum="8673C4DAAAB86E50" modified="2018-11-07" version="1">MDNEGGGKKALVSQGTTTTTTTTTTTEASRLQRIAVKGLASLHILRGLLCLAYPAASSGLLSGLLVGGERSGATNLLSALVGVRDVLLGCLLATASGSHDVRRALAVNLVSDAADTFILIFAAACAWQRGATPVAEIGVVASVAILEHLTLWSLASGGGGMLRRRRMRRGCRRMRIRSCVLICGLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5Q4</accession>
    <name>A0A367L5Q4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">pyridoxal 5'-phosphate synthase</fullName>
            <ecNumber evidence="4">1.4.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_4138</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.5" evidence="4"/>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5Q4"/>
    <dbReference type="STRING" id="1330021.A0A367L5Q4"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="UniPathway" id="UPA01068">
        <property type="reaction ID" value="UER00304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004733">
        <property type="term" value="F:pyridoxamine phosphate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000659">
        <property type="entry name" value="Pyridox_Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019740">
        <property type="entry name" value="Pyridox_Oxase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019576">
        <property type="entry name" value="Pyridoxamine_oxidase_dimer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00558">
        <property type="entry name" value="pdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004231">
        <property type="entry name" value="PRK05679.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851:SF0">
        <property type="entry name" value="PYRIDOXINE-5'-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851">
        <property type="entry name" value="PYRIDOXINE-5-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10590">
        <property type="entry name" value="PNP_phzG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000190">
        <property type="entry name" value="Pyd_amn-ph_oxd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01064">
        <property type="entry name" value="PYRIDOX_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="9">
        <location>
            <begin position="70"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridoxine 5'-phosphate oxidase dimerisation C-terminal" evidence="10">
        <location>
            <begin position="213"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI09754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="255" mass="28474" checksum="3912E105A4058148" modified="2018-11-07" version="1" fragment="single">ISLPVRNSSGSGSMADEGGSGSGSGTKLISSSSQAEQFTLSQLRLADLNRSPAQQFQSWFSEATTTKGTPHPETCVLATSSLPTGRVSARVVYMKEVDEQGRFVIYSNLSSSRKAADLATNDNVALVFHWEALQRQVRVEGKAERLSAAESQPYFDSRVRSSRLGAWASSQSEVLVPDAAVRGDDGRRALELAVERMEDRFRHSDHIPVPDFWGGLRVRPLAVEFWQGRESRLHDRFLYQWDDEDERWTIKRLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L672</accession>
    <name>A0A367L672_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DHHA2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_3959</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L672"/>
    <dbReference type="STRING" id="1330021.A0A367L672"/>
    <dbReference type="OrthoDB" id="374045at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004309">
        <property type="term" value="F:exopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.20">
        <property type="entry name" value="DHHA2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1640.10">
        <property type="entry name" value="inorganic pyrophosphatase (n-terminal core)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001667">
        <property type="entry name" value="DDH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038763">
        <property type="entry name" value="DHH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004097">
        <property type="entry name" value="DHHA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038222">
        <property type="entry name" value="DHHA2_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112">
        <property type="entry name" value="BNIP - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12112:SF39">
        <property type="entry name" value="EG:152A3.5 PROTEIN (FBGN0003116_PN PROTEIN)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01368">
        <property type="entry name" value="DHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02833">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01131">
        <property type="entry name" value="DHHA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64182">
        <property type="entry name" value="DHH phosphoesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DHHA2" evidence="5">
        <location>
            <begin position="240"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI09722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="394" mass="43019" checksum="73663755F494F30C" modified="2018-11-07" version="1">MPLSRRTTLQSFLSTARSVLCAPASQRPTPLTLVVGNESADLDSLCCAIVYAYLRSHQENGEQTPGGLHIPLANLPRADLGLRPEMTAVLAHAQLRPSDLITLSELPDLSSTDSSTRWILVDHNALTGTLARFAPRIVGCVDHHEDEGCVPDDASPRIIEPCGSCMSLVVDETRHEWDSLTASDADGDDALAKLCLAPIVIDTVNLSPSAKKAKPKDTRAVGYLEAKLSDPDNFSRDAFFHEISAVKDDISRLTMRDVMRKDYKEWRENDLVLGVSCAVADLAALVEKAGAPEQLLDSLSSWADERSLDVASIMTASSLGGRFHRNLLVWGRSPRGEATIARFVEDASGPLRLQTWSRGELDDGSCSRFAWDQKELAASRKQVGPLLRHAMRKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6D6</accession>
    <name>A0A367L6D6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oxidase ustYa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_8424</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI09984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6D6"/>
    <dbReference type="STRING" id="1330021.A0A367L6D6"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF11">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI09984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="158" mass="18124" checksum="7F6441DB82912209" modified="2018-11-07" version="1">MADGDLQGAKELFGVEPSKEPAKEAWRSLIPRGKGFVMIRNSTSLADFPGLKHAEREEQQACVAVFHQLHCLYMTYAAYWDARAGKFDEIPPRHLIHCWDYLRQSIMCAGDTSLEWVSEHQPLPNATTGWGFQHTCKNFDAIYDWAERHRSKENEGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6J4</accession>
    <name>A0A367L6J4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carboxy-cis,cis-muconate cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6J4"/>
    <dbReference type="STRING" id="1330021.A0A367L6J4"/>
    <dbReference type="OrthoDB" id="1715191at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000244">
        <property type="entry name" value="Carboxy-cis,cis-muconate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050282">
        <property type="entry name" value="Cycloisomerase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344:SF4">
        <property type="entry name" value="CYCLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75011">
        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="377" mass="41931" checksum="AAC193D9CC239F52" modified="2018-11-07" version="1">MPLHHLIVGTWTPPGAIFTFAFDDVALTLRLVKRTAIPEDEPISWMTFDHAKRNIYGAAVKKWSSFAIHSPTSIIHSSSHPLSHNALAPSPSSDTRAIFLLAASSPPYGVYCSPFYSHATSGTVFAVQPDGSLDRPVQTFDYGPGSAVHGAVFHPDGRHLFSADLSANKIWLHRRRLRPDAPAPDPELETVAYSVPAPDPHDHPRWVAVHPTGRFLYVLMESGNRICEYAISHDHDDNLRPVFTGRHFSLLPDADDPHHPPEPGARYRGDVCALSSSAQYLFASTRGAKPHHRGFLSAFRLRPDGSIDRRLMVRVTPNSGGHSNAVSPSDWSDDWVAVVEDQDGWLDIYRWQDDMLQSVARVRVDEPGFGMNVLWYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6R2</accession>
    <name>A0A367L6R2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_8458</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6R2"/>
    <dbReference type="STRING" id="1330021.A0A367L6R2"/>
    <dbReference type="OrthoDB" id="4204700at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI10111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="407" mass="45650" checksum="14E23227DFCF892A" modified="2018-11-07" version="1" fragment="single">RGRGIVTSFTESLEGHRKSPIIITITITIIIIIMADDPQVSEEAMLRERLQRRAQYQPAVHDQVQRMYASYRPPLHALVFGWNRDKMLLFTEETAVGFASFAESPISDDQLRAVGQHCDDAINTLHIMKMCGVGLAGYLTYRGRKTFRFPLYTPKGNGFFNPFATTPYNRLMWHMARFASYYALYGILMGPPAAAATNLLAIKLAMLDPRMSELMKRGNELHPPNSHQKDENQWNSSPQQEPITDEASMDAERSISGQARSAWRTPSQQDAWDRVPDDMDDASPAAPSSSRYDAGNGGGSAWDRVRQQSLGGHPGQQSRQRRDAWNASRDKADPDSRGNDGSGERRGRENYSFSSSDGDKAVAKSQSQEEFDRLLERERRGIDQETGSGLVAQYGQHGHDTETMRCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L774</accession>
    <name>A0A367L774_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_8749</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L774"/>
    <dbReference type="STRING" id="1330021.A0A367L774"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021476">
        <property type="entry name" value="Egh16-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34618:SF3">
        <property type="entry name" value="GEGH 16 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34618">
        <property type="entry name" value="SURFACE PROTEIN MAS1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11327">
        <property type="entry name" value="Egh16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="2">
        <location>
            <begin position="158"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="585"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="697"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="737"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI10280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="769" mass="82174" checksum="E97A00D20336B471" modified="2018-11-07" version="1">MATHCSGIPIIDLRPFESGTSEEIAECATELFTAFKTVGFAYIKNHGVPQEQVDEAFRWSGKFFALSEDVKNKAPTPPKDDIAEKRKVPDCKESFEIGSEESKRMPNIWLPEDDIPGFRAFFNRFYKTCYGVEVKILRAIAIGMGLEETYFVKCHSIHNNQLRLLHYPPVKDALLRNGKVESIGAHSDFGTLTLLFQDNVGGLEVEDVHEKGTFRPAVPIPGTMVVNIGDLLMRWSNDELKSTLHRVRTPPRADNDDDDDGDDDGDVEDEERMTLTRYSIPYFICADDNTMIDCLPGCHGPDRPKKYEPVNCNEVVSDVPGPEGIGFRVEPNLPNNCSDIIPCQQDSTIIRPEEIARNLVNPCGRTQMHGNIDVGQETEKAILEDKVPIVNRGSVLQVTLHQVNADGGGPYFCDLDETSNGGIFSHNLTIQNNVPGANGLSLVVAKNFTMELQLPDNFTCIGGSTGNICTIRCQNTALAGNFGGCFPIKQADTEPHVNRPETNTIADDETRIQSLQRIAESTIPIAIQGIEKAGGDDALRLRENLNRLTASKEKDEVALGDTVRNVDPKSNEIITGDAPGKGGVQSQQSNQNQPQGNQNQPQGNQNQPQGNQNQPQNNRNQPQGNQNQPQGNQNQPQNNRNQPQQPQQQQGNFPNDQQGQAANNKFNQGQAFSQGQGGSNLQLGGLGGSQLGQASSNGGGGGGSQQSNKGGSGGSSGGSSGGSSGGGGFQQGRASSNGGGGGGGGGGFQQPNKGGSGGSGGGSSGGGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7C4</accession>
    <name>A0A367L7C4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20 21">NADPH--cytochrome P450 reductase</fullName>
            <shortName evidence="20">CPR</shortName>
            <shortName evidence="20">P450R</shortName>
            <ecNumber evidence="20 21">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">cprA</name>
        <name evidence="24" type="ORF">L249_4304</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20 21">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="20">Binds 1 FAD per monomer.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="20">Binds 1 FMN per monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="20">Endoplasmic reticulum membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Mitochondrion outer membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Cell membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the NADPH--cytochrome P450 reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="20 21">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="20">In the N-terminal section; belongs to the flavodoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="20 21"/>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7C4"/>
    <dbReference type="STRING" id="1330021.A0A367L7C4"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06204">
        <property type="entry name" value="CYPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
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        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="CysJ-like_FAD-binding"/>
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        <property type="entry name" value="Flavdoxin-like"/>
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        <property type="entry name" value="Flavodoxin/NO_synth"/>
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        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
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        <property type="entry name" value="Flavoprotein-like_sf"/>
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        <property type="entry name" value="FNR_nucleotide-bd"/>
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        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
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        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
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        <property type="entry name" value="P450R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF17">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
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    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
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        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD_binding_1"/>
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        <property type="match status" value="1"/>
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    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
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        <property type="entry name" value="FPNCR"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 20" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 20 21" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 20" id="KW-0274">FAD</keyword>
    <keyword evidence="3 20" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 20" id="KW-0288">FMN</keyword>
    <keyword evidence="2 20" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14 20" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 20 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="15 20" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 20" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9 20 21" id="KW-0521">NADP</keyword>
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    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 20" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="18 20" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="13 20" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="17 20" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="22">
        <location>
            <begin position="65"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="23">
        <location>
            <begin position="273"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="71"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="122"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="448"/>
            <end position="451"/>
        </location>
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            <name>FAD</name>
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    </feature>
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        <location>
            <begin position="466"/>
            <end position="468"/>
        </location>
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            <name>FAD</name>
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        </ligand>
    </feature>
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        <location>
            <begin position="483"/>
            <end position="486"/>
        </location>
        <ligand>
            <name>FAD</name>
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        </ligand>
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    <feature type="binding site" evidence="20">
        <location>
            <position position="549"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
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        </ligand>
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        <location>
            <begin position="611"/>
            <end position="612"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
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        <location>
            <begin position="617"/>
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            <name>NADP(+)</name>
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        </ligand>
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        <location>
            <position position="653"/>
        </location>
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            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
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        <location>
            <position position="691"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00022630"/>
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            <dbReference type="ARBA" id="ARBA00022955"/>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
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        <source>
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    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRNR" id="PIRNR000208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RCI10327.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="692" mass="76930" checksum="ECF9D9FB1A1FB0BB" modified="2018-11-07" version="1">MAVLDTLDIIVLTAILIGTVAYFTKGTYWGVVKDPFANAFANANGVAPGRTRNIVEKMEESGKNCVVFYGSQTGTAEDYASRLAKEGKSRFGLETMVADLEEYDYDNLDTFPSDKVCMFVLATYGEGEPTDNAVDFYEFITAEDVSLSEGNDPPLDNLNYVAFGLGNNTYEHYNSMVRNVDKALAKLGAHRIGDAGEGDDGAGTMEEDFLAWKDPMWAALASKLGLEEREAIYEPTFDIIDRPELTRESREVYLGEPNKMHLEGTAKGPFNAHNPYIAPVVASRELFSAKDRNCIHMDIDISGSNLTYQTGDHIAVWPTNPGDEVDRFLDVIGLTASRHKVVSVKALEPTAKVPFPTPTTYDAIIRYHLEICAPVSRQFLATLAPFSPTEEARAEMTRLGSDKDYFHQKTGPQFYNIARLLAAVGKGERWAKIPFSAFIEGLNKLQPRYYSISSSSLVSPKTISVTAVVESQAIPGRGDAFRGVTTNYLLALKQRQNGDPDPEPFGQTYEIDGPRNKYDGIHMPVHIRHSNFKLPSDPSKPVIMIGPGTGVAPFRGFVQERAKQAENGVPVGRTLLFFGCRKRTEDFMYEEEWEECKKSLGDKFEMITAFSREGKKKVYVQHRLKERASDVSDLLSQKAYFYVCGDAANMAREVNTVLAQIIAEARSVSEQKGEEVVKSMRAANQYQEDVWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L801</accession>
    <name>A0A367L801_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_4298</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ribonuclease III family. Mitochondrion-specific ribosomal protein mL44 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L801"/>
    <dbReference type="STRING" id="1330021.A0A367L801"/>
    <dbReference type="OrthoDB" id="67027at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19873">
        <property type="entry name" value="DSRM_MRPL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044443">
        <property type="entry name" value="Ribosomal_mL44_DSRM_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044444">
        <property type="entry name" value="Ribosomal_mL44_DSRM_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207:SF32">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="RIBONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22892">
        <property type="entry name" value="DSRM_MRPL44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="9">
        <location>
            <begin position="75"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI10362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="387" mass="42907" checksum="34C14A565AAC5018" modified="2018-11-07" version="1">MKRLRLARWSGPALQARPLARRRSPFLETKRCQHEAAAAPAVDGPQPPPRQQQQQQQQPLLPSPPPSRASSSAKLAALHARLSLPQKVPIQTLARVLISPTADPNPAFNNSTLSYLGSCIINYHVLEYLVCKWPRLPIAILYETLRAYAGDESLHEVCKRWGVEAAAAPGEEVDPGLLQWKPEPTKPSEAWWGYVRPDAERAASFRRGLSSRIVLDDDFGDLIDKPGADVDREFDRLYSLAHASVVQATVGAIYSHCGREAAKSFIISHILSRSFDPSVLFAFKLPTREISMLCAREGFQPPVARLESETGRLSRTPVYVVAIYSGQEKLGEGAGPNLDIARRKACMVSLKAWYLYSPGNKVRVPSDMLEEEAKPWTPPHIDIGEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8G7</accession>
    <name>A0A367L8G7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_4372</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8G7"/>
    <dbReference type="STRING" id="1330021.A0A367L8G7"/>
    <dbReference type="OrthoDB" id="288203at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018045">
        <property type="entry name" value="S04_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01130">
        <property type="entry name" value="SLC26A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="7">
        <location>
            <begin position="543"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="582"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="703"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="920"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="585"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="606"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="920"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="945"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="967"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="996"/>
            <end position="1006"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI10522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1046" mass="115350" checksum="43853C6ECDE8227F" modified="2018-11-07" version="1">MGNQRALDFFASRVLDMDSSRQAETRDEDEPPGPIETYTEDEPTVGEWFGQLAPTWAGAGSYVVDLFPSASWIRRYNLRWLAGDLIAGITIGLVVVPQALAYASLAQLPPAYGLYTSFTGAALYWLFGTSKDIVIGATAVGSLLVGQVVSRVQEASADTYKPEETAHMLSLVTGLILLGFGLLRLGWIVEFIPYIPISAFVTSASITIMSTQLPVALGIPKVDTRQPPYLVMISTLRGLNRIRLDAAIGLSAIVLLFVVKSFCSVMEKRQARFKRGWAYVSSLRLTFTMLLFTLVSYVVHRKTEETKFRIVGHIDRGFVQAAMPVPKMGLLREILPELPAVAMILVIEHIAIAKSMGKMYGYSVDPSQETVALGAANLLSPFVGGYVCTGSFGASACLSKAGARSPLAGLFSAAVLVLVLYALTTVFYYIPNAALAGLIIHAVCNLVISPKKLYGYWQLSPPELIIWVVSVVLAIFTSLETSIYVGIGLSSALLLVRMARSKGDFLGRVRVRQVSATNGEQLDDGSRDVFLPLDGKDGTNPDIKMESSPYPGVFVYRLNEGFNYTNQAHHMERLNRQIVSTTRAGADEERQQHLERDSDRLWNDPGPSSSSSTKMTTNARQQTLPRLRAVVLDLAAVNHVDVTSVQGLMDLRSCLDRHAAPDKVSWHLANVHNRWTRRALTAAGFGRADGKAVTVSHYDAAETQAYSDDETRSTPDEETGWGSTTPVSEQSRLATVCAVDRPLFHLDLRDAMLSHTLSSLPARDLARARVVSRRFEACATRLLHRRLSQGWHSQAGSKLLLDSYQPSERVSTPYLSCRFRGTRVLGRETVEKITDVYSSFRPFVADDVVRFLASSRGHDVEEGEDEKEATQTIELDQGETLSQLCVATNLVRYSSVLVSHVRTCEGVVRLWRRWLAEMADEDNNDEEEEEEEEEEEEDEEKGYTSSSSSGSSSSSSATPSTGLLWVDGDRNVGLRFRVDPPSAPAPLRGPERNGEEEKEEEEEEEEPPVRYRLVYRELLVRSCTLLIAMEAAEAGHDVMMAQFPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8X0</accession>
    <name>A0A367L8X0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5442</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8X0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI10871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="70" mass="7673" checksum="C2EEBB2959797432" modified="2018-11-07" version="1">MGYVRVLQVGTLKYLEKIISISFSHLLNTNTSPASNSSLIASFRLSRDSSSSSLSRDHLPDSSTLYPLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8Y1</accession>
    <name>A0A367L8Y1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5407</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8Y1"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI10877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="151" mass="16397" checksum="38834358593108AF" modified="2018-11-07" version="1" fragment="single">DFFATADTNNKESEDKSSLFSIRALEPLNYKLAGPFPPTRIVASLIERTRSAILQEEASNIVDCDKETSSKLSNLGATTPSNPFSTSDNNSILGLALPDLPTLLSIRIKVQQAKAALAVKKITAKKEKPIAKKISFKNPTLFCAEGRESDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L919</accession>
    <name>A0A367L919_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Zinc finger RING-H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_5336</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L919"/>
    <dbReference type="STRING" id="1330021.A0A367L919"/>
    <dbReference type="OrthoDB" id="8962942at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16485">
        <property type="entry name" value="mRING-H2-C3H2C2D_RBX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024766">
        <property type="entry name" value="Znf_RING_H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12678">
        <property type="entry name" value="zf-rbx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger RING-H2-type" evidence="11">
        <location>
            <begin position="82"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI10920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="138" mass="15790" checksum="34D4B349C2530F6F" modified="2018-11-07" version="1">MADVEMRDAPTAAKRADGAADKEKAPEGRKKFEVKKWNAVALWAWDIVVDNCAICRNHIMDLCAFMHVPFFLWQDADRATRAGIECQANQASATSEECTVAWGICNHAFHFHCISRWLKARSVCPLDNRDWEFQKYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9G4</accession>
    <name>A0A367L9G4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7467</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9G4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI11065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="84" mass="9615" checksum="F2EAA415CDFF1B7F" modified="2018-11-07" version="1" fragment="single">RDIPYNDYAKAVTRIRHFLKSCNLYLARYLSTLRLMRYNVLVRASRRELIIYSADNLVVYSSAARQVSNPIVAIIGSTFASLVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9I1</accession>
    <name>A0A367L9I1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">VHS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_7530</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May play a role in the regulation of membrane traffic through the trans-Golgi network.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Binds to ARF1 and ARF2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9I1"/>
    <dbReference type="STRING" id="1330021.A0A367L9I1"/>
    <dbReference type="OrthoDB" id="2018246at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14235">
        <property type="entry name" value="GAT_GGA_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16998">
        <property type="entry name" value="VHS_GGA_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.160:FF:000003">
        <property type="entry name" value="VHS domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000008">
        <property type="entry name" value="VHS domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000024">
        <property type="entry name" value="VHS domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052653">
        <property type="entry name" value="ARF-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008153">
        <property type="entry name" value="GAE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47180">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47180:SF1">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-BINDING PROTEIN GGA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50180">
        <property type="entry name" value="GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="10">
        <location>
            <begin position="31"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="GAT" evidence="12">
        <location>
            <begin position="194"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="GAE" evidence="11">
        <location>
            <begin position="472"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="432"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="560"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="353"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="432"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="564"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00053552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00065344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI11078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="610" mass="65691" checksum="AD5291F568C45869" modified="2018-11-07" version="1">MEAASARAAARDRWSDFGRTPSQLQRFVSAACSPDNYEPNLALNLEICDLINSKKGSAPREAATAIVGYINNRNMNVALLALHLLDNCVKNCGYPFHLQISTKEFLNELVRRFPERPPIRPNCVQAKILEAIEEWRLTICDTSRYKEDLGFIRDMHRLLSYKGYVFPQVRREDAAVLNPSDNLKSADEMEEEEKEAQSAKLQELIRRGTPEDLREANHLMKIMAGYDNRSKTDYRAKAAEEIGKIQAKARLLEERLEAFKPGDSMTEGDVFSELASALQSAHPKIQKMCEEESDDHEAVAKLLEINDSIHRTVERYKLMKKGDTEGAAKLATAASTGGTAELSLIDLDADVNGGGNSGNGNGNGTSQAPTGLENDLLGLDLSGDSSTFGQGGNIALGFGANQNVPGPALLSSMTQDSSAGGNLKTPTMTPMMSSSPFSSFASLSQSTTTTPHAQPGTKSKAAADDDEWNFTSSLPPETAPREYSLLVSDTSLRTEMMAKRNGNAIRILFSFSNKTTQPISELHFQLAVTKGYELQLQPQTGRSLSPSQLRGVTQVVDVFHAEDGGGGGGGGGGGGGGGGGLGSSLPSCVGELPIGSGLRRLFVLRRREGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9X7</accession>
    <name>A0A367L9X7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial phosphate carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_7240</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Transport of phosphate groups from the cytosol to the mitochondrial matrix.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9X7"/>
    <dbReference type="STRING" id="1330021.A0A367L9X7"/>
    <dbReference type="OrthoDB" id="427452at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035434">
        <property type="term" value="P:copper ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000076">
        <property type="entry name" value="Mitochondrial phosphate carrier protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000131">
        <property type="entry name" value="Mitochondrial phosphate carrier protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="101"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="198"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="11">
        <location>
            <begin position="299"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI11231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="399" mass="43102" checksum="E54B8DFA57880582" modified="2018-11-07" version="1">MGDFFAGLTRGVARSRGEAGGSLKLGSLGRAVAGLYLGSVTKVSPISICRSAAMPLPPQIKLEPPESSGARPTPYRGRPELYSAASMSDAKAGTIQLYSGRYYAACTFGGLLACGLTHTAVTPLDLVKTRRQVDSKLYSGNMQAWRSIFRAEGFRGIMTGWSPTLVGYSAQGAFKYGWYEYFKKTYSDMAGPDAAARYKTGLYLAASASAEFLADVALCPFEAVKVRMQGTMPNPYSGTWAGISAVTGKEGWAGLYKGLYPLWGRQIPYTMMKFASFETIVEMIYHRLPGEKNDYGKGTQTAVSFAGGYLAGILCAIVSHPADVMVSKLNAYRQPGEAFGRAMSRIYGDVGFAGLWNGLPVRIVMIGTLTGLQWMIYDYFKIFMGFPTTGGTPVPTEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAH6</accession>
    <name>A0A367LAH6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">18S rRNA aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="6">2.5.1.157</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">TSR3</name>
        <name evidence="10" type="ORF">L249_7545</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1191 (Psi1191) in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N(1)-methylpseudouridine(1191) in yeast 18S rRNA + S-adenosyl-L-methionine = N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine(1191) in yeast 18S rRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63300"/>
            <dbReference type="Rhea" id="RHEA-COMP:13852"/>
            <dbReference type="Rhea" id="RHEA-COMP:16309"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an N(1)-methylpseudouridine in rRNA + S-adenosyl-L-methionine = N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine in rRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63296"/>
            <dbReference type="Rhea" id="RHEA-COMP:11634"/>
            <dbReference type="Rhea" id="RHEA-COMP:16310"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
            <dbReference type="EC" id="2.5.1.157"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TDD superfamily. TSR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.157" evidence="6"/>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAH6"/>
    <dbReference type="STRING" id="1330021.A0A367LAH6"/>
    <dbReference type="OrthoDB" id="10262062at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106388">
        <property type="term" value="F:rRNA small subunit aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01116">
        <property type="entry name" value="TSR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022968">
        <property type="entry name" value="Tsr3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007177">
        <property type="entry name" value="Tsr3_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002621">
        <property type="entry name" value="PRK02287.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426:SF0">
        <property type="entry name" value="18S RRNA AMINOCARBOXYPROPYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN TSR3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="Fer4_RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04034">
        <property type="entry name" value="Ribo_biogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNase L inhibitor RLI-like possible metal-binding" evidence="9">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="16S/18S rRNA aminocarboxypropyltransferase Tsr3 C-terminal" evidence="8">
        <location>
            <begin position="79"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="212"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="238"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="265"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="358"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="393"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI11413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="410" mass="45100" checksum="77D3A035EF8FD32D" modified="2018-11-07" version="1">MVRHKKDLAHRGRKPNHHAAIPSSSSASASASASASASASFKAACWDLGHCDPKRCSGKRLMRLGLMRELYLGQRYSGVVITPNAKQVISPADTELLVQYGAAVVECSWARTDEVQWSKVGGKAERLLPYLVAANPVNYGKPWRLNCVEALAAAFYICRRPDWAEQVLAPFSYGPTFIRINLTVLDQYAACQDDAAVKKTEAEWMQTLEREYAESRERDADDVWAGGNTNHRGPLATSEDEVDDGDDDVASSDDRSVDGIYLGKRVTDPKPGEEPALPDKDHHHHHHPFDISSSSSDDDEAAMAEIRRKVLASKTFTNPNRDPDNDQGHDAATTKPVTIPRPLVLDPDPPRPDSDNGSSDDDEDDEAFDRIIDATPVTDKVGLTKLEKERSRAAASNRSYSSRVLSAPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAH9</accession>
    <name>A0A367LAH9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_7330</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. Binds one iron-sulfur cluster per dimer. The iron-sulfur cluster is bound between subunits, and is complexed by a bound glutathione and a cysteine residue from each subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family. Monothiol subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAH9"/>
    <dbReference type="STRING" id="1330021.A0A367LAH9"/>
    <dbReference type="OrthoDB" id="415696at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015036">
        <property type="term" value="F:disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03028">
        <property type="entry name" value="GRX_PICOT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02984">
        <property type="entry name" value="TRX_PICOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000012">
        <property type="entry name" value="Monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000092">
        <property type="entry name" value="Monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033658">
        <property type="entry name" value="GRX_PICOT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="GLUTAREDOXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293:SF73">
        <property type="entry name" value="GLUTAREDOXIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00055846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI11438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="256" mass="27865" checksum="89A80090E88EE242" modified="2018-11-07" version="1">MSTITEITSSSQWDQLLSSAPASALLVVSFHAPWAAPCAQMAKVLSTLASEFPVTEPPTTVWASINAEDLSEISQMYDVTAVPFLVLLRDGRVVETVSGSSAVKVRAAIETHARGGAEKQANGLDTVADQPQVNEQTPAELEKHKEKLFKRLHDLVNAAPVMLFMKGTPSSPQCGFSRQIVAILRENSVKYGFFNILADDEVRQGLKEYGEWPTYPQLWIDGELVGGLDIVKEELANDKDFLKPYCAATVPESTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LB09</accession>
    <name>A0A367LB09_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Clock-controlled protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LB09"/>
    <dbReference type="STRING" id="1330021.A0A367LB09"/>
    <dbReference type="OrthoDB" id="2441642at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013927">
        <property type="entry name" value="TF_Opi1_Ccg-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR OPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38406:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR OPI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08618">
        <property type="entry name" value="Opi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="461" mass="49760" checksum="B14E15F0A7B58B4C" modified="2018-11-07" version="1">MPVSSSKDIAPSSFEPPPDPKEPPTVSDSWSNTLSVYRPPGEDQSKRQRLPEDPDVLLAAQALGELRADFVSKPPSDRSCPSSSRSEPAVLPRSEPLLSLLTTSHPLVASTIGGASSAYGGAKNLSPRFKSGAEYVEGYLTPIANTVNSVGRVTGVEGGVRWFLGANRRPAPVPDSDVDEAYSHKRRKVRDGGGGGGGGDGDGEGATPLNLWYTDPRTLRRLSSTSTIDTLPLYDEIRSPAYTEETTGPSQNASRPAAPWQSRLMLSTSGLSVAMSAESLRSLKYCLRWLRWTNDHMGRVIGTLKATVEEYEQTRPPVPPHSGNGPVVDPEPSRVELVNRINTLKSDIIKTLQNTIETVSKYAGGALPENARALVRRHLTSLPQRFRIATMSAGGDGDGGRDSESAISEGAKRMLVLAKEGLDMVTQVSGVVDGTIMSAEEWCERMGRKRDSPRDDDEQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LB35</accession>
    <name>A0A367LB35_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 6">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="1 6">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_7656</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="1 6"/>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LB35"/>
    <dbReference type="STRING" id="1330021.A0A367LB35"/>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13360">
        <property type="entry name" value="PH_PLC_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08598">
        <property type="entry name" value="PI-PLC1c_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000049">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037755">
        <property type="entry name" value="Plc1_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF36">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="8">
        <location>
            <begin position="824"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="79"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="174"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="719"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1135"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="721"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1140"/>
            <end position="1157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI11626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1157" mass="127297" checksum="5F5FAF6F6DEADDBE" modified="2018-11-07" version="1">MPTDADPSLMSQPSHGPNPPRSLFSTHLRRARPSQLQTNFHPQPHGQHYAFSASALASSPRLTSPLVTSPDAVALTRHSSIQASPEFVPRPRGGEDDQHPSTLHLPDSVLSPRTTSATTCLPSPWSATDNLHSSSSGALSATSSNIPVNLGHYHSSNCTCTPAAKTNLIRRLSSRASRRIASRRRQSSAAPASRDGSVGPYLRRRSDSNSTAPADCLTRSTDSDSDLDERNDFASLGSLYFESAFRGSSANSTAESVAGSADNMSGPVIPPQLKCGTWLRKISRKNRSKRIRLVYEPETNKLMWDRLRPAKFLHVDEIREIRTGTDILQYGRDFNVPEPERSTWFSILYAVPDKSRTKFLHLIADDVETCFIWTYFLKALLRHRQEVMASLMTFNDRAMAQFWQGEMARQSAVGDVPRPDEHDELDAAGVSRVCQNLHIYSSQATVQANFRLCDARRRGRLNFTEFLAFVRLMRQRTDVQRIMRSAAAHPEAGLTLPEFLTFLRDSQGEDVASATGAAAAWERIFVKFVRKHRSGGDAVNGHHANAAAGVMPEAAFAGFLSSRHNGPLVDEPGEYTLDRPMNEYFISSSHNTYLLGRQVAGHSSVEGYISALARGCRCVEVDCWDGSDGQPQVVHGRTLTSAISFKEVMTTINKYAFVKSSFPLWISLEVHCCPAQQALMARTMKEAFGSRLVTEPLDPTSDKLPSPSQLMERVLVKVKKSGGGGGGGGSGGGGGSNQDGPLAGETPRRGRGRSLSSPAVRPPPPEPASLPQSPLLLASRRLVGKSRVNTITEGQVHEELFSSDTESETGGFLGRSANKTTKVLGALGVYCAGVKYFGFDSAEAKTFNHIFSFMESSFARHSRTKESKMALDMHNMRYMMRVYPDGMRVASSNYDPLIYWRRGVQMAALNWQTFDLGSQLNQAMFAGGRDESGYVLKPTELRDIQVRPFDLAIAKGKKERTVVCFAIDVISAQQLMRPANLAAGKSMDPYVEVQVLHANDKRDKKEAGVTLVHVDDSPLRYRTQVVRENGFNPVFSGGPFRFRVTTKHPELVFVRWCVRLASYGEGKDGSVIATYTAKLQNLKRGYRTLPLLNHAGDQYLFSTLFCHISPVGTETKLFDALPAAQEGSKLNRLGGRVFGSRSNTSPRSTFETSSLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBR6</accession>
    <name>A0A367LBR6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_4183</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000009">
        <property type="protein sequence ID" value="RCI11873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBR6"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI11873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="60" mass="7434" checksum="C4B5B127DEA83D91" modified="2018-11-07" version="1" fragment="single">KKEEESRNSLKEEIKEELEAGEVFVLRRYFSRYFKVPTYRTLTYLYKISDLEEDLYVIYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBS5</accession>
    <name>A0A367LBS5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L249_7455</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the histone H2B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBS5"/>
    <dbReference type="STRING" id="1330021.A0A367LBS5"/>
    <dbReference type="OrthoDB" id="10254238at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000014">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6 13" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="12 13" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="11 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="15">
        <location>
            <begin position="30"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCI11864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="137" mass="14829" checksum="5CADF7223734A4F2" modified="2018-11-07" version="1">MPPKAADKKPAAKAPATATKAPEKKDAGKKTAASGDKKKRSKTRKETYSSYIYKVLKQVHPDTGISNRAMSILNSFVNDIFERVATEASKLAAYNKKSTISSREIQTSVRLILPGELAKHAVSEGTKAVTKYSSSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LC74</accession>
    <name>A0A367LC74_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ENTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_0670</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LC74"/>
    <dbReference type="STRING" id="1330021.A0A367LC74"/>
    <dbReference type="OrthoDB" id="44015at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030136">
        <property type="term" value="C:clathrin-coated vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005545">
        <property type="term" value="F:1-phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048268">
        <property type="term" value="P:clathrin coat assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16988">
        <property type="entry name" value="ANTH_N_YAP180"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.150:FF:000004">
        <property type="entry name" value="ENTH domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.150">
        <property type="entry name" value="ANTH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011417">
        <property type="entry name" value="ANTH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014712">
        <property type="entry name" value="ANTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045192">
        <property type="entry name" value="AP180-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951">
        <property type="entry name" value="CLATHRIN ASSEMBLY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22951:SF5">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-BINDING CLATHRIN ASSEMBLY PROTEIN LAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07651">
        <property type="entry name" value="ANTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="4">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="459"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="533"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="459"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="485"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="533"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI12017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="583" mass="64604" checksum="70D5DF54AE8A829E" modified="2018-11-07" version="1">MTSSFEKSVKGATKIKNAPPKTKYIEHILVATHSDAGTNDVFRALQHRLRDSTWTVVLKSLIVVHLMIREGSPDVALAHLARSRNMLALGHFSDGPLPCRRRSLADADRITAQTQGRNIRHYASYLSERAKAYRDTKTDWVRAPESRLERLSVDKGLLRETEVVQTQLTALVRCDVLESEPQNDITVLVFRLLVLDLLSLFQVLNQGLINILGHFFEMSKPDAERAMDIYRTFTKQTDAVVQYLSVARLHEHHTRVEVPKLKHAPVNLGRQLEEYLKDADFEIHRRQYIAEQEAKKKGTRVATTKTVKAADFPDPPSSFAIARKPQANKGPDPDLIDFFGSIEQNQTPMQTDPQQQLFNAAPFQPQQQTGMPFVSNGFAPQPTGFAANDGFMQQPALAQANYTGVGFGGLTTPQPQGFQPGALGSIPQDSVANFTNQSPAGMQTGMGTNPFRQSMLMAQQTGMQQRPSSQPTLSPNRQSTNPFARSPPPGSSPFQSQPPAPLQPTLTGTNPFARTSLQPQAHQQDMLMPQATGLTNPFRQSSFTNQATGMGWQQNQTPIGGGFDQLPTIPVFPRPAQQTPWQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCF4</accession>
    <name>A0A367LCF4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyl transferase family 25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_0555</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCF4"/>
    <dbReference type="STRING" id="1330021.A0A367LCF4"/>
    <dbReference type="OrthoDB" id="47375at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06532">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050757">
        <property type="entry name" value="Collagen_mod_GT25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002654">
        <property type="entry name" value="Glyco_trans_25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730:SF53">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730">
        <property type="entry name" value="PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE/GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01755">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl transferase family 25" evidence="4">
        <location>
            <begin position="76"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI12091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="395" mass="43854" checksum="E54B4865AC08776C" modified="2018-11-07" version="1">MTSSPRPLLGVWTMAAMAQGRFCLLTVFLICILLLARRQAEVISFSKSLRTTRTLSSVPMVEASLDDTGNATLGFEKIYALSLPSRHDRRDGIVLQAAFTGLTIDFADGLDGDSMSEKSVPKTEQNVAAIGGGELGAWRGHANIWREIVQRNLGSAFIMEDDSDWDLRIKRQFRDLALATRALVQPRVVAPGQDEGDELAFDRLPATKPPRHSPYGDDWDIIWAGHCGQVFVEESERPKKRVIQLGDETVPQKKWLSKPFYDPITLKEKYPNHTRAYHHSEGAVCTLGYAVSQRGARKLLNELALRTPVLPCDFLVRVFCEGSQGLGPGTCITTQPPLINSHWPRGPLQDQSNIRLEESGFREKAETRITRWSARINAGVLLGGKGPVDGWPDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCX0</accession>
    <name>A0A367LCX0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SPX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_0009</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCX0"/>
    <dbReference type="STRING" id="1330021.A0A367LCX0"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006797">
        <property type="term" value="P:polyphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01115">
        <property type="entry name" value="SLC13_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14478">
        <property type="entry name" value="SPX_PHO87_PHO90_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004680">
        <property type="entry name" value="Cit_transptr-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283:SF92">
        <property type="entry name" value="LOW-AFFINITY PHOSPHATE TRANSPORTER PHO91"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10283">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 13 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03600">
        <property type="entry name" value="CitMHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="386"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="437"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="488"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="531"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="570"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="613"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="638"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="666"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="706"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="751"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="794"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="8">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="103"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI12273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="823" mass="89936" checksum="C8FCDC4AA7BF4653" modified="2018-11-07" version="1">MKFSHSIQFNAVPDWSSHYIAYSNLKKLIYQLEKSAHQSRSGDTESRPLFAADNPDDVFSAALNVELDKICSFYAAKQDELLSDVTQLLRDIGNRSSSLERGTAPLRRVVSDGQRGNAVASDDEDGGDDSASDDDETTGLNKPNQRLFVSYRQDMASSAELAPSRRLSNTIDCYDEPHLFISPGLHSSAIMLKKRIIGLYVQLCELKSYVQLNRTGFTKVLKKFDKILFRELKFSYLRTRVDTAYPFRSETKKLIDDSIAKLEAAYADVITGGDAGLANKELRSHLREHVVWERNTVWRELIGIERRAEAARLGQSLLGQDQGVALQGDGDDALPALKQFRTPLGRLSLPQWLANGSIATLAVSVAIFFALLLIPLLQKPEQQNCLAMLVFVSILWATETIPLFVTSLLVPFLSIVLRVVREEDPDKTPVRLDSRDATHAIFASMWTPVIMLLLGGFTLAAALSKCTIDKRLATLILSKAGTRPRTVLVANMFVAAFASMLISNVAAPVLCYSIIDPMLRTLPSDSDMSKAIIIGIALASNIGGMLSPIASPQNVVAMGIMDPEPTWLQWFFIVIPVGAVSLLLIWLLLLVTFQPGKGTVIAPIRPLKEAFTGVQWFVSMVAIATVAMWCASQHMEGVFGDMGVIAIMPIVLFFGIGILTKEDFNNFPWTIIILAAGGLSLGKAVRSSGLLHLFAEVVSDGVEGMSLYGILFVFSSLILVIATFISHTVAALIFLPLVYDVGAVMKRPQPNLLVMGGVLMCSAAMGLPTSGFPNMTAIMKEDAAGQRYLRVKHFITRGVPSSLITLVVVMTLGFGIMEVAGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LD56</accession>
    <name>A0A367LD56_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_0472</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LD56"/>
    <dbReference type="STRING" id="1330021.A0A367LD56"/>
    <dbReference type="OrthoDB" id="2102561at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF6">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI12347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="305" mass="33406" checksum="2BBB1CECE1E7F76D" modified="2018-11-07" version="1">MDRGRKPSVLITGCTPGGIGHALALEFHARGTAHIVLPVSAPRLTVIQSLEANGLTVLPLDVTSQESVASCRAKVGDITNGKLDILVNNAGRPCVMPALDNDLDDARATYETNVFGPMRMVQSFIDLLIPARGLILNIASGSAELPYLFSSVYSATKAALLQYSRVLRMELKPFNVRVTTCMAGTVRSNFTGGPQRPLPSKSLYQPVADFYSRRLAFSQNNRTMPHDVFAKKVVSQALLGEGWLGGWIGGTPDYLWVGGFSTLVFFSTWMPRWIAEGLTAVYFQMRAMGKRIQAARQKNREIKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDF2</accession>
    <name>A0A367LDF2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0432</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDF2"/>
    <dbReference type="STRING" id="1330021.A0A367LDF2"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="113" mass="11935" checksum="9FFC4CA2807DDD73" modified="2018-11-07" version="1">MAPDRHSLALFPLEEKVALGLTVLNSSGGSATTSSSYPPPEDSPVGGAPPPYIKCEKPRVPDSPEPLHLGRHRHSASASSCWHPSSPLARTPLVPPSSDMPLLPDRKGKSRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDI8</accession>
    <name>A0A367LDI8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Stalled ribosome sensor GCN1-like HEAT repeats region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_0416</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDI8"/>
    <dbReference type="STRING" id="1330021.A0A367LDI8"/>
    <dbReference type="OrthoDB" id="951172at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000313">
        <property type="entry name" value="Importin beta-2 subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000219">
        <property type="entry name" value="Importin subunit beta-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057546">
        <property type="entry name" value="HEAT_GCN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032157">
        <property type="entry name" value="PAC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23271">
        <property type="entry name" value="HEAT_GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16093">
        <property type="entry name" value="PAC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Stalled ribosome sensor GCN1-like HEAT repeats region" evidence="7">
        <location>
            <begin position="295"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="492"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="494"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF23271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI12485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1100" mass="122757" checksum="604D66E82B906F36" modified="2018-11-07" version="1">MAEEQMHLVQLSVAVPQFPDTRIYIRISKLVKALLVSLTTASPDETGAAKTMGSFVYALPNRFNDRETLSTVFFAHEPTLDPTTRLAKLIARRAQLPTYVTNSMNFSDTGTVDEEMSVFRTVAEVVLERLLAFHPSPPSPKRRRRLLTTRIRFVPTAPAMAWQPAPESLRQLATYLKDSLSGFNKDAQKQAELMLEQAKSSPDINNYLAFIFSSADPPDGLQCGEQDYHVVRSAAGIMLKNNVKSQCKSIPEASLQLVKLAVPMGLQDKNVQIRNFAGNIATEVIKRGGLLAWPELLPQLLDMIGNASGQVSTEAQEGAMSALAKICEDNTRMLIREVNGQRPLNFVLPHLIAATKSSLPRVRVGALTAINVFTPRESQAMLNSIDDLLQHLFILSADDNCDVRRQVCRAFVHLVETRPDKLQPHIGGLVDYIISQQKCDDEDLACEAAEFWLAVGEHTDLWRALQPFLVKIIPVLLECMVYGADDIALLGGQSDDEDEQDREEDIKPAFAKKNQARAANGEESVPKSGDAYEKLNNMDEGLEEGEVSDDDFDDGDDGYPDERWTVRKCSAAALDVFARDFRGAVFEAIFPYLSQNLKHEEWPHREAAVLALGAVAEGCMNVVVPHLPELIPYLITLLEDPEPVVRQITCWTLGRYSPWAAELTDPAQKERYFVPLMDGILRKMLDKNKKVQEAGASAFANIEEKAGKRLEPYCGPIIQQFVRCFARYKDRNMYILYDCVQTLAERIGPLLATPELANQLMPALIERYNTVSDESREVFPLLECLSYVALALSHAFAPYATPIFVRCVNIIHTNLELSLAAAVNPALDQPNKDFLITSLDLISAIVQALEGDKAVELVENAPHPFFELLSFCMEDPTDEVRQSAYALQGDCAKYLYPRLQPHLPTMLPILLKQLDMDSVLDEEIDSGFGVVNNACWSAGEIATQHGKGMAPWVPELLQRLVEIMCNPRVPKGLSENSAIALGRLGLHSADLLAPSLPSFAEEFLNAMQEVDPSEEKATAFKGFSMVVGVNPQAMEKVLMSYFESIARYQDLNLRNPIKQELHEVFQNVLNVYKRMIPQFNEFVSQMRPQDQQSLKNNYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDQ3</accession>
    <name>A0A367LDQ3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_0291</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDQ3"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI12547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="84" mass="8997" checksum="90AB2036AA9DC2EF" modified="2018-11-07" version="1">MPMRGGREIQRCGRWDGGEAFVLIRGMKLARLHDVVEAESGLLVEGDGDAVTGPSLQISNTIPSITLYPASLNPAPLPATSFYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LE13</accession>
    <name>A0A367LE13_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Trafficking protein particle complex subunit BET3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_0550</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Golgi apparatus</location>
            <location evidence="1 8">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LE13"/>
    <dbReference type="STRING" id="1330021.A0A367LE13"/>
    <dbReference type="OrthoDB" id="10262857at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14942">
        <property type="entry name" value="TRAPPC3_bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000001">
        <property type="entry name" value="Trafficking protein particle complex subunit BET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016721">
        <property type="entry name" value="Bet3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13048">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018293">
        <property type="entry name" value="TRAPP_I_complex_Bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="13"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR018293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI12664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="216" mass="24966" checksum="CC2EC5A953F5B165" modified="2018-11-07" version="1">MVMQRWRPARLLGSAKSMSPDQGTRNGRRTDREQDLERRARIDKVNAELVTLTYGTIVAQMCKDFEYDYGEVNKQLDKMGYNIGLRLIEDYLAKSNTMKRCANFRETADVISRIGFKIFLNITPQVTSWTTDNNQFSLVFDENPFADFVELPDDGRAQDELWYSNILCGVLRGALEMVQMQVEAHFVSDVLRGNDTTEMRVTLIRYIDDELPPEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LE38</accession>
    <name>A0A367LE38_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pre-mRNA-splicing factor SPF27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_1002</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPF27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LE38"/>
    <dbReference type="STRING" id="1330021.A0A367LE38"/>
    <dbReference type="OrthoDB" id="205794at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008409">
        <property type="entry name" value="SPF27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13296">
        <property type="entry name" value="BCAS2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13296:SF0">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SPF27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05700">
        <property type="entry name" value="BCAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI12681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="24026" checksum="1EAF32F30E6C563A" modified="2018-11-07" version="1">MTKAPPPDSLPYIDAEPTESEKASARALISHELETNPPSSPPLLPPAHEASFSAAITSELERISADKPSTPLPLSRYEAQDAPEGEKGIHVVRPALEASYVSAEYLALRGRNLSLLDSHGVNAWLLHNHHLDSIRDRTERQRRDVAAEVDVVNATRQSLQVAAKAELDALDREWRKTVGRVLETELDVCRLEAEIRRLRRALLQSPSAALPTDSLTNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LE81</accession>
    <name>A0A367LE81_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_1060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LE81"/>
    <dbReference type="STRING" id="1330021.A0A367LE81"/>
    <dbReference type="OrthoDB" id="6407410at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021369">
        <property type="entry name" value="DUF2985"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35872:SF1">
        <property type="entry name" value="ALPHA-L-RHAMNOSIDASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35872">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G07110)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11204">
        <property type="entry name" value="DUF2985"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI12734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="360" mass="40465" checksum="8DCF5251EE7B7A13" modified="2018-11-07" version="1">MPSLNTPANAAKTTSPPRWPQPTDPSFKGFGGFELSPLPDSAQKDRSPMHLTTAKNGRHHAINSFVGLPYELEPPAAADFPNGYHFPPRHSFVESLKLSTMAFLKYVRTPMGFLITLYCLNVVAWGGMIFLLSLNAAPAMCRPTCEDNNSPRKIWIEIDAQILNALFCVIGFGLAPWRLQQLYLLMRYRVRGDKRYLRRLAGIHREWFRLAGSTTIPPFIGPHNVEVAALEDQLSAIPSPETKIPVVPLTGVRAPPTRAWKLDLVIWMRVFNTLLQVGLATLMWAFNRFNRPAWATNLVVVMACAAGTVDGVTVLREKRTIKRVEGVPVTEKDQERLKSDKARGIWHYNNIKDKDLSGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LE95</accession>
    <name>A0A367LE95_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_1273</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LE95"/>
    <dbReference type="STRING" id="1330021.A0A367LE95"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF9">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI12737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="38520" checksum="2CA051EEC5AB8BF8" modified="2018-11-07" version="1">MHRVLLDVISPASSRVLIGRPPCRDRRWLRLAVDFPKDVFIMASILNLLPGWSHCIVARLIPARRRILKSIRLADDTVARAGRQHAAVKEARARGEQVEEEDTLLNWMLDRRSPNECLPSAMGALQCALTLAAIHTTSMTALHLIHDLCEHPEWLPVLRDEVDSLADELGGPSEKPMATTEEWCDRLEKLDSFLVESQLRNPMTRMAKQDMRLYDGTRVRSGTVLAFAACEPDEPFDPMRSYRLRRASWPDQRDGHRAGAAHRANLTFGYGSQACPGRHFAVAEVKLVVARLLLEFDFKFLPRQSRPWTFDLNEMVLVNPWAKMLMRRRRTTRRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEJ6</accession>
    <name>A0A367LEJ6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DWNN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_0973</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEJ6"/>
    <dbReference type="STRING" id="1330021.A0A367LEJ6"/>
    <dbReference type="OrthoDB" id="106784at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16620">
        <property type="entry name" value="vRING-HC-C4C4_RBBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014891">
        <property type="entry name" value="DWNN_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033489">
        <property type="entry name" value="RBBP6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025829">
        <property type="entry name" value="Zn_knuckle_CX2CX3GHX4C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439:SF0">
        <property type="entry name" value="CELL DIVISION CYCLE AND APOPTOSIS REGULATOR PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15439">
        <property type="entry name" value="RETINOBLASTOMA-BINDING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08783">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13696">
        <property type="entry name" value="zf-CCHC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01180">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51282">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DWNN" evidence="9">
        <location>
            <begin position="5"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="8">
        <location>
            <begin position="180"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="353"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="542"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="378"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="542"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="564"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI12836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="584" mass="63610" checksum="1C1838849D9251AE" modified="2018-11-07" version="1">MASSVFFKFKSQREPTRVEFDGTGISVFELKREIITRSGLGDGTDFDLFIYTDDNADEYDDDTTIVPRSTTVIARRQPATKPGAGRAARYVSGKMPVSAKNAGRREHAVKAAAAKSSANAVNQMNSASTEEEKMAAMFAAQSEQWSAQQEELSHQAPVYKAGSKRPANVPDHDPPNGYICYRCGNKGHWIQLCPTNDDPDFDNRPRVKRTTGIPRSFLQKVDKSIVLAQSDGDDTKRPSGIMVNAEGDFVIAEPDKASWEQFQAKAKSSTVNKEALVENKEVQERGLECSIDKKMLIDPMMTPCCQKTFCNDCITNALIESDFVCPACQTEGVLIDDLTPNDETSKKIQEYLREKEAAKSPPPASTGGMEQNAQADGGHSETVKDDAKKKVSPASSPPKGPKSQAADAKQDPPPAEGNSRKRPADDFLENPKIPKGPKAMQNMAPMPPNMMSGMPNMGMNDMMFNGMGMMPNMMGVPNMNMGMNMNMGMPMMGMPMMGMPPGFPAMNGGGGFGGMNGAGWGMNGVDMAQGGHMGIGQGITNGFQHGEGFNQSNGDDDAYFRKPVNPHRHQNKQRRVRPSDYREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LF03</accession>
    <name>A0A367LF03_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Histone deacetylase</fullName>
            <ecNumber evidence="3 11">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L249_0017</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the histone deacetylase family. HD type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="3 11"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LF03"/>
    <dbReference type="STRING" id="1330021.A0A367LF03"/>
    <dbReference type="ESTHER" id="9hypo-a0a367lf03">
        <property type="family name" value="Arb2_domain"/>
    </dbReference>
    <dbReference type="OrthoDB" id="424012at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031078">
        <property type="term" value="F:histone H3K14 deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000005">
        <property type="entry name" value="histone deacetylase 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019154">
        <property type="entry name" value="Arb2-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017321">
        <property type="entry name" value="Hist_deAcase_II_yeast"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF5">
        <property type="entry name" value="HISTONE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09757">
        <property type="entry name" value="Arb2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037919">
        <property type="entry name" value="HDAC_II_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0678">Repressor</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="13">
        <location>
            <begin position="92"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Arb2-like" evidence="14">
        <location>
            <begin position="470"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR037919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF09757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCI12997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="736" mass="82251" checksum="76D65CEAC8C28051" modified="2018-11-07" version="1">MLEMEESKPMDSVGLPAEDVVMKNGFDDRENGIADSYDAVSEQGSYDGKSEPDAEELALEQLRRRGLLPTGCCYDDRMKLHMNADFSPNTHHPEDPRRIHEIFKAFKRVGLVYSGPDSELPKIIKDCPNRYMWRIPARPATRDEIRLAHSSDHLAWVENLESVSTAELRDLTKKYDQGRESLYVGSMSYPAALLSAGGAIDTCKNVVIEQVKNAFAVIRPPGHHAEWDSPMGFCFFNNVPVAVRVCQRDYPSICRKVLILDWDVHHGNGIQNIFYQDPNVLYISIHVYQNGQFYPGKPPNPMTPDGGIESCGSDEGLGKNINIGWHDQGMGDGEYMAAFQKIVMPIAKEFNPDLVVISAGFDAADGDELGGCFVSPACYAHMTHMLMSLADGKIAVCLEGGYNLTAISNSAVAVARTLMGEPPPKMQLPKINKEAARILAKVQAHQAPYWECMRSGIVDIPEVQSLNASRLHDVIRDAQRQRLQNDYGMIPLFVQREQLYKSFENQVLVTPNLREAKRILVIIHDPPQVVAQPDAVDTSVESHNAWVLDGVAQYIGWAVSNKFGIMDLNIPSYITHEEDAEACEPGLGEKMLQKQIQELVCYVWDNFLELYGTDEIFLLGVGNAYLGVKLLLINRDCKFRINGVVNFVTGNLRPVKSDVDTDLSSWYKDNSRVYVSSDHACWSDYELMRKVTKKRFGTVVRSRALGLNRLMQEHAEEAQAWILGRTGVSASGDSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LF08</accession>
    <name>A0A367LF08_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SMP-30/Gluconolactonase/LRE-like region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0463</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LF08"/>
    <dbReference type="OrthoDB" id="9977941at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052998">
        <property type="entry name" value="Hetero-Diels-Alderase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42060:SF1">
        <property type="entry name" value="NHL REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42060">
        <property type="entry name" value="NHL REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016762684" description="SMP-30/Gluconolactonase/LRE-like region domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="36137" checksum="553B13F208A2D7F6" modified="2018-11-07" version="1">MRLSAPGIWSVAFTLLGLPLASTAAGGAAAEAGQNVTTKNLPRRTVAQFDAGTWIENIAVRSSGALLLTSLMPNASLYEVPDPTSESATVTRLFTIEDASGLLGISEISTDVFAIAGGNVGSSGGVEGSMRVWTVDFSSSASPQPQLAMTIPEAILLNGMTTVPNKDKVVLISDSAKGVVWRADIGANKSEIAIQVPEMGSQNQKQPIGVNGIHIRDGNLTWLNHDTFKMFSIHITEDGLQAPEAKAAEVASFPVTALDDFIFGPAEQATAWVTTNSDNRVFALEASGESVVVAGANNLPDVATATACQFGRSEKDGKVLYVTTGGDEIEGKHGGKVEALDTTSFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFB7</accession>
    <name>A0A367LFB7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0227</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFB7"/>
    <dbReference type="OrthoDB" id="5374757at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40635">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40635:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="280" mass="31947" checksum="FB22A5C02881A6F2" modified="2018-11-07" version="1">MAPVRRYLRISKSSVLECRIYLDNPSLAQSWLLNPRDPVLPRIIESVRPLVVPKLREERERARKKGTKKKSIKDVVIQDDFEVSIFLTETSSRHSLLLKHKHFREKAPDRLRSNSTKLIGETNRAPIDVDDDDDQYAAATVVLQEDDDEDEVQLADIPVAPPMTRRKRRRNTALEVDDNEDEYTDDDNMAIEVTSDAEEPASKRRRQAGASEDVDDDKKKLAMDVTYEGFAIYGRVLCLVVKRRSREARSEAINKSGGQGQARMENWITSTQVPVGEDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFS5</accession>
    <name>A0A367LFS5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6593 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFS5"/>
    <dbReference type="OrthoDB" id="4725912at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046528">
        <property type="entry name" value="DUF6593"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20236">
        <property type="entry name" value="DUF6593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6593" evidence="1">
        <location>
            <begin position="18"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="169" mass="19221" checksum="24C082B2F8E3CD4D" modified="2018-11-07" version="1">METLHIYSPHFFSRKLQVTDSEKHTVLYNVRYKTLGRPDMIVNRGQGKDDDNVIGSLTFRCWSSDIDAETPLGRIQMTKKSCFSGSHHFTCDGSTWCWKRGGGFYCHLQLVDDNGRPVATLERPAWACRKQGTITVLQEVSSSTLDVIVITALAKLEAKRRQERRNQGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGE4</accession>
    <name>A0A367LGE4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_5595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGE4"/>
    <dbReference type="STRING" id="1330021.A0A367LGE4"/>
    <dbReference type="OrthoDB" id="4151352at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053095">
        <property type="entry name" value="Actin-binding/GATA_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23246:SF13">
        <property type="entry name" value="GH12359P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23246">
        <property type="entry name" value="NEW-GLUE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="131"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI13496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="346" mass="37920" checksum="13D7A72FE2C6D0FD" modified="2018-11-07" version="1">MAPKHDAQGALSHYPGQLLPPSSSSSSSSSSIYGQQRMTLPASYFPVASSSASSSLPLPPHPAPSQQQHSHPSQNPAAQLPSQLPPHLHAQLPPQLTPHLPPQPEPQHHQRHQDQPDYDSYTEHVPLPPSQHRASSGAWSPQNDHQLVAARMQGLNWGQIKDAYFPSKTANACRKRHERLMERRGAEDWDHRKLQRLAKEYMSMRREIWSGLAARTGERWNVVEYKCMSNGLKNLQSAARAASRRDRLETSSHHVPGYDDDSGISGIALTPVDELDASYNSSPETSSANNGVLLHGLAGHGYSSSVSSTASGAVIHRRFTPGRGPYVDGQRMPDMGIGAIINRPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGK5</accession>
    <name>A0A367LGK5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_1224</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGK5"/>
    <dbReference type="STRING" id="1330021.A0A367LGK5"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF82">
        <property type="entry name" value="FAMILY CHAPERONE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G08575)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="63"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="81"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI13392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="647" mass="70991" checksum="0B7217BD3072F368" modified="2018-11-07" version="1">MSLTSSSRGSCFGETEAINGPVREPAPVSDRLIVGVDFGTTYSGVAAVYTSTPDDVEIIKTWPGGNGITSDKVPTEIAYRSPSPSSSSSPSPSSSSPPSTSTARWGFQFRPDESRLRCIKLFLDRSQKLPFYVSHHDTAAQLKRFNKNVVDAVADYLTHIHRHTMDTLGRRYGESFMTSTKVDFVLTCPAVWSDGAKNTTLLAAERAGMGHRSEIQMISEPEAAAVYTLKAIQPNHLSVGDNFIVCDAGGGTVDLIAYKILSLKPLRVEESAVGTGGLCGSAFLNYRFEDHVRNRLGVARFDDMKLRKGKTWQMGLRYFEEFVKRNFNLEEHHHEFNVPFPGLADDEAAGLDSGFLLMTAEQIGDIFEPVVKQVCDLVQGQVDGLRSKGGVVSGIVLVGGFGQSDFLYRRLKSHFTSAAPPPPYSERPTHAGGGAAAAVGSLSLSLSSSSSSSSSSSSSSSIEVMQPVYAWTAVVRGAVLRGLEGRSMVLSRKARMHYGTSYATVYDEGKHSLAERYWSPLWERWMVSDRMQWHITKGESLSPLSPIAFHYTRNFRPGQSLLVTDDLLASEEDEPPPSYTRRLLHVCTLTTDLRAVPKSLFTRLTTTRGVEFDNLDFTLEMIVDSAGLGFELKVDGVRYGRVEAEFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGR3</accession>
    <name>A0A367LGR3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5466</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGR3"/>
    <dbReference type="STRING" id="1330021.A0A367LGR3"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI13608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="97" mass="11006" checksum="36D3073BF198FFC2" modified="2018-11-07" version="1" fragment="single">KIRTNKATFRDKEDRIGFLFRSLEGKACKTLETYLLTKTKDNSLSYEDFCGYVKDAAVKRLDAKLVLPNDLPALAKYSLSILLPKTPLLNRQINLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGX9</accession>
    <name>A0A367LGX9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prolyl 4-hydroxylase alpha subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_8214</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGX9"/>
    <dbReference type="STRING" id="1330021.A0A367LGX9"/>
    <dbReference type="OrthoDB" id="272077at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051726">
        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF3">
        <property type="entry name" value="ACTIVATOR OF C KINASE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Prolyl 4-hydroxylase alpha subunit" evidence="6">
        <location>
            <begin position="40"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="232"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="930"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="548"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="940"/>
            <end position="955"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI13693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="961" mass="106548" checksum="3E5D7FE45BD045F5" modified="2018-11-07" version="1">MPKAKPSANRPAVEKAPEWPRFKPSLPVADLTPQLHPATAKIALVPFFFPRSLCRDYVAFFRTLPLQTTPARPKRGEAARVNDRFQVDDAVFARRLWEQTGLKEALTEDDKVKHLWVYRYSKGQYFDCHYDDENNVELATDPPTSARTTWTLLLYLTSAAEGCAGGETVFYPHDRKSWAEAIVVPPETGLLLLHKHGDDCLLLCGHDATTTHHVSLGNAPLTCRTLQADMSFHSAGGPQRPYAPPPPRGHGDWQMPPQQHAGPRRPYDDGYGHYGGPDPRGRPAIRRPPLVNGPESYPGPPREYHAYGEPGPDRSQFAIPGRSLTMPPQEAVQRQGPMPPRADTMPSHDPASRGAVPPRPATATGSRPPPRRMYQHPSQGQPQEWHGRPYRQETSDDVFNSYFTPPPPRQPNLPEAEEAPPFQGRGPPPRIHDEEEEEEILINRRGYTTPSPRPTFAYQPEHPGSYGRGGGGFDPMAPPPTRGPSGHGNGQRFRGFEPRSGTAPPQMVSPDALPSHPTPVRPGLMANSMVSVSDRPPPVRNYNGVPQAGPPQPMPPPPPQHQQMPQQPVRAGHQVPVPVMGQPVTPAELERLRVAIKHNANDQDSALLLARKLVEAADVLTAKMPDAKQRARTRDRYLVDAHKILKKLANAQNQEAMFIMADGLGKGLFGHEPDNKEAFTLYHSAAKLGHAAAAYRTAVCCEIGQEEGGGTRKDPLKAMQWYRRAATLGDPPAMYKVGMIQLKGLLGQSKNPREAVGWLRRAAERANEENPHALHELGLLYESAQSNDVIIRDERYALSLFQDAADLGYKFSQFRLGCASEYGLMGCPIDPRQSIYWYSKAAAQGEHQSELALSGWYLTGSEGVLGQSDTEAYLWARKAAVAGLAKAEYAMGYFTEVGIGVPANLEDAKRWYWRAAAQEFPKARERLEDLKRAGKHGRPRERERISRSRIERQQEGECSVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LH75</accession>
    <name>A0A367LH75_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LH75"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="98" mass="11106" checksum="B5E255840E48B21D" modified="2018-11-07" version="1" fragment="single">AIAQSSRPKRKLLPPRLLFNRDKTLFLAHYLKSCNFYLARCLFILCFLATSLREILLALCVIPTPKAPPVISLLSKVFNFANLFSKEKASALLPYYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHQ4</accession>
    <name>A0A367LHQ4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_8160</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHQ4"/>
    <dbReference type="STRING" id="1330021.A0A367LHQ4"/>
    <dbReference type="OrthoDB" id="28053at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016482">
        <property type="term" value="P:cytosolic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00322">
        <property type="entry name" value="FNR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008153">
        <property type="entry name" value="GAE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50180">
        <property type="entry name" value="GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GAE" evidence="8">
        <location>
            <begin position="655"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="9">
        <location>
            <begin position="760"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="531"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="596"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="549"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="596"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI13929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1047" mass="114170" checksum="F298CF1B8FEB3AD8" modified="2018-11-07" version="1">MSSLKQFIRNVRAAKTIADERAVIQKESAAIRASFREESADHGVRDLSHSNQYIVGLALCTLGNIASVEMSRDLFPEIEQLISTSNPYIRRKAALCAMRICRKVPDLQENFLEKAAHLLADRNHGVLLCGLTLVTSLCEADEDEEGGDNEEATIEKFRTFVPGLVKTLKSLSTSGYAPEHDVTGITDPFLQVKILRLLRVLAVGDAETSEQINDILAQVATNTDSSKNVGNSILYEAVRTILDIEADSGLRVLGVNILGKFLTNRDNNIRYVALNTLIKVVAIEPNAVQRHRNTILECLRDPDISIRRRALELSFTLINESNVRVLIRELLAFLEVADNEFKPTMTSQIGIASDKFAPSKRWHFDTMLRVLSLAGNYLKEQILSSFIRLLATTPELQPYAVQKLYANLKMDITQESLTQAAAWCVGEYADMLLRGGQYEEEVIQPVKESEVVDLLALILNSSYATQVTTEYIVTALMKLTTRFSDASQVERIRRILQNHQTSLDVEVQQRAVEYGNLFSFDEIRRGVLEKMPPPQIKEESRVLGPAPTKKNKGANRKSRVVKPTEQDLLDLMDAPPAAAAPANGSQASNSDLLADILGGGAAAPSPVSSTTSSQQQQPATSSSIMDLFGSEPSPAVSRSSAALDLMGDSAPPSKSGPAGHACYEANGLQVTLQLQRNAEGAIQATAVFQNRAGSAPLSNVGLQAAVPKSQKLQLLSISSSEVAVGGSATQMMRISGCKGVLRLRLRIGYTHPTAGTVMDQEFHEGIVIRVDQVNERIRLFRLELRSGPAKFLPGQWVDAFVPGVAQPGGFTITSVPSRASTPTKPYLELAVAQADGNAVAEWLWRPRQEVVGDELRLRIGGSFVFPPLDERLAVKDGHGRGSGMRSLVFVAGGVGINPLFSMLGYVAESGLDVDDVRLLYATKLPRSGRLEDVLFLRDIAALFGQRKLRGSIRLYVTATATATGATTAAEAGATTQMDTRHICGASVSVRPGRISAEQVRSVVRRHDPNETLVYICGPPLMTDELVAALTAEEDVLDSKRILTEKWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LI03</accession>
    <name>A0A367LI03_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7966</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LI03"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI13882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="53" mass="6214" checksum="22D40BB18AB2790B" modified="2018-11-07" version="1" fragment="single">YNNVAIRYTFPFVLQRVDRLQRADRYDGCLVPRLIGCYDRYRYSAPIAVTIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LID8</accession>
    <name>A0A367LID8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mago nashi protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_5949</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mago nashi family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LID8"/>
    <dbReference type="STRING" id="1330021.A0A367LID8"/>
    <dbReference type="OrthoDB" id="6495301at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11295">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1560.10:FF:000001">
        <property type="entry name" value="Protein mago nashi homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1560.10">
        <property type="entry name" value="Mago nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004023">
        <property type="entry name" value="Mago_nashi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036605">
        <property type="entry name" value="Mago_nashi_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638:SF0">
        <property type="entry name" value="MAGO HOMOLOG, EXON JUNCTION COMPLEX SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12638">
        <property type="entry name" value="PROTEIN MAGO NASHI HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02792">
        <property type="entry name" value="Mago_nashi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89817">
        <property type="entry name" value="Mago nashi protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI14206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="154" mass="17808" checksum="7CE3B7E0EE4B97BB" modified="2018-11-07" version="1">MSSTSEPFYLRYYSGHMGRFGHEFLEFDFRVVGDGRSAVTRYANNSNYRNDSLIRKEMCISSVLVDEIKRIIKASEIIKEDDSKWPQKNKDGRQELEIRMGNDHISFETAKIGSLVDVTESADPEGMRVFYYLVQDLKALVFSLIALHFKIKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIF7</accession>
    <name>A0A367LIF7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphatidate phosphatase APP1 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_6187</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIF7"/>
    <dbReference type="STRING" id="1330021.A0A367LIF7"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019236">
        <property type="entry name" value="APP1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052935">
        <property type="entry name" value="Mg2+_PAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208:SF2">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1 CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09949">
        <property type="entry name" value="APP1_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016661186" description="Phosphatidate phosphatase APP1 catalytic domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidate phosphatase APP1 catalytic" evidence="3">
        <location>
            <begin position="295"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI14223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="538" mass="58273" checksum="D84E2A158B5E935C" modified="2018-11-07" version="1">MLRPVVVTVTLLCAVASCSPTPTPAPSSAMATPPPTMAPTTTPRIEVRGLGSKAASYLSSLADEAGSKVSSFANSGILDFPFGFPTGSEVLKSADVSETGLAALPTEVLNLPPYGNWTDQGWNVRVHGNVYKTPNISESKIDSLANVFLIGTSVEELQPQEQAQARNLTRSIFIVQQGDRSVTMDFVNDVSVRPNASGGAVNAGDRSVTMDFVNDVSVRPNASGGAVNAGGGSQKIKLPFNTTAQGDFDVFVKLDQNTRGLMDGNKTSRIQTLNLYAEGTDTGNATAYLVPAKGVTIVSDIDDILRVTKIYQPKEGLLNTFARPFRAWENMPQIYANWSSSMDDVHFHYLTTTPEQGTRLYMDFIYKTYPLGSFDTRPLNFSDLKATLAIRKSLLDKVFQTFPERKFILVADTSNSDVMKDYPRLYHEHPDQVLCIFLRNTSATDPSDRFPYDTSGFRGIPQQNYMFFTVPDDLKGLNVLGGQCHNESVRQNVTFRTQGLPFGLSGDDEASGASMAVVRIAFAAVVSGLAGVSLAGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIS6</accession>
    <name>A0A367LIS6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribose-phosphate pyrophosphokinase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_6042</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribose-phosphate pyrophosphokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIS6"/>
    <dbReference type="STRING" id="1330021.A0A367LIS6"/>
    <dbReference type="OrthoDB" id="413572at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002189">
        <property type="term" value="C:ribose phosphate diphosphokinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004749">
        <property type="term" value="F:ribose phosphate diphosphokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006015">
        <property type="term" value="P:5-phosphoribose 1-diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006164">
        <property type="term" value="P:purine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000063">
        <property type="entry name" value="Phosphoribosylpyrophosphate synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000030">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000056">
        <property type="entry name" value="Ribose-phosphate pyrophosphokinase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029099">
        <property type="entry name" value="Pribosyltran_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005946">
        <property type="entry name" value="Rib-P_diPkinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01251">
        <property type="entry name" value="ribP_PPkin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210">
        <property type="entry name" value="RIBOSE-PHOSPHATE DIPHOSPHOKINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10210:SF36">
        <property type="entry name" value="RIBOSE-PHOSPHATE PYROPHOSPHOKINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14572">
        <property type="entry name" value="Pribosyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13793">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01400">
        <property type="entry name" value="Pribosyltran_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribose-phosphate pyrophosphokinase N-terminal" evidence="3">
        <location>
            <begin position="5"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI14319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="401" mass="43509" checksum="0D6FC6A0284CA44B" modified="2018-11-07" version="1">MVRNIVLLGGNSHPLLTESVCNILCLPPGDRTLTRFSGGESRCEIKDSVRGKDVYIIQSGSGRVNDNLIDLCIMVSACKTGSAMRVTAVIPLFPYSRQPDWPYNKSGAPLSLPASNQPVKDYTFESVPATPRPGLPPTNGLANGAHSLADKLATAADHTGLFTTHDYENPSSISAFQPKPGYKQWVAQAGTLVADLLTCAGADHIITMDLHDPQYQGFFDIPVDNLYGKPLLQSYIQKHIPDYKDAVVVSPDAGGAKRATAIADSLEIDFALIHKERRPIKFSDQRNASMMLVGDIANRVCILVDDLADTANTITRAAKLLKREGATRVYALLTHGVFSGDAISRLNASAIDKIIVTNSVPQDEHCRLCPKLEVLDISPIFAEAIRRVHHGESISKLFQNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJ23</accession>
    <name>A0A367LJ23_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein uL30m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_6174</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJ23"/>
    <dbReference type="STRING" id="1330021.A0A367LJ23"/>
    <dbReference type="OrthoDB" id="509901at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01658">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000010">
        <property type="entry name" value="Large subunit ribosomal protein L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005996">
        <property type="entry name" value="Ribosomal_uL30_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018038">
        <property type="entry name" value="Ribosomal_uL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01308">
        <property type="entry name" value="rpmD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15892:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15892">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00634">
        <property type="entry name" value="RIBOSOMAL_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="9">
        <location>
            <begin position="4"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI14262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="86" mass="9617" checksum="F0E78A48EC89B780" modified="2018-11-07" version="1">MTFFRITLKRSAIGLPARTRGALSALGLRRRTQTVFKPVNVSVAGMLMRVKELVCVREVEAALGKEELRGERRPDAGFYVERAVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJ61</accession>
    <name>A0A367LJ61_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_6148</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome b5 family. MAPR subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJ61"/>
    <dbReference type="OrthoDB" id="10257697at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050577">
        <property type="entry name" value="MAPR/NEUFC/NENF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281:SF76">
        <property type="entry name" value="CALCUTTA CUP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10281">
        <property type="entry name" value="MEMBRANE-ASSOCIATED PROGESTERONE RECEPTOR COMPONENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="3">
        <location>
            <begin position="104"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI14440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="263" mass="29262" checksum="D3D2BE63E10C2548" modified="2018-11-07" version="1">MNDSSSPSSSSELRRRKADNDNQPQEKQPSAKKYQSSSAADADESYSPWLLDGLRVLTFLLVASCGLSYVISGGDSWSWGVTPSRPNYLKPAWWKAKLTGPLYLTPQELAAYNGKDEGKPLYLSVNGTIYDVSKGRHMYGPGASYHIFAGRDSSRSFITSCLDQPDDVPDLRGGEDAFLPLDDAEIDSHWTTAEMAAMRAEELAEAKIRAHAALKNWVDFFAGSEKYHFVGYLKWDPAELQGRPVRPLCDKAQEGRSKRSRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJC6</accession>
    <name>A0A367LJC6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJC6"/>
    <dbReference type="OrthoDB" id="5307331at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="618"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="742"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="789"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="803" mass="88300" checksum="1FA119C30E404B75" modified="2018-11-07" version="1">MHANASTPSSSMIPTFHDPGVNLDYAAMDQFFSGTVPDAGLIDPTLSAFVGAGSATEPAAGGEPVRPDDIVFPAADMSASNNTVAPSRLSRGQGTSSNSGTQHSNRPDLQGNVPQGLPHFVQPNPSPALLDPGSVLPAPTPYLTQHPQQQPSTEHSTLLEVGLRGTQPASGLPPSKDGQHRQGPYQHNGPSPPRYSSNPAWYVGTGRLNAQGAVAGHPSSPLSSDRQRTGGPHYPLFQPYERPSGRPISLYPPPSYAVKPVPPYGNPGLGPSPLSNVFHGNTAAGPAEQNVAAAIKSPSLYLDLDNSNNNNNNNAPAAPKTLSGLGVAQTWAKSDKCEPSFAVSDEMENGRVMSARAAKKTNSMHKADPSNVYKEHDRLPKSKPFGPRSLDGRPLFTYTKDGQLAEDRVYSKEELQIYLDDHRSVLWIQQSPAQCASRLHYDDRRCRWDKCPLASRVIGSGWFRVAFDEHPQQTTKGGKDPFKVAGIMHLWCFEQCFDIVDFFVDNRVRPDTRILPRETGNAMSINRDSDREIVREAFDPWFDERRRYRKVHGVERMPRQHHDTLSYRLSKHHVENQTGARQKARDNRNKGRPWKERTTIDVHLGDLQVYVYHSNYKKNAKRKKNRAGGNTDGGGRRASLAKRRGSSFVAEMVNGSVPMTGAASVNGGFGVTDERDFLPRPSGPVVGNVPQAGDDHLEAAARQELKMMSDKEDVDNEAIWQRQPWQTFIFDETDSNPLMNFVGDPAFGPVSSTAMSSQDRTEQLNEGPRKRKRDEDLSETMAAEDGERPKRHCTGASEKRKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LK45</accession>
    <name>A0A367LK45_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone chaperone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LK45"/>
    <dbReference type="OrthoDB" id="4357148at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="100" mass="10920" checksum="C0FFB3F00B92B344" modified="2018-11-07" version="1">MSAESDYVSRQGDKSEIPVQADDARVDDPIDEDTADTDAQLGRSSILRIIGHALKLTLTKARDEKDAIDTSNIIKEKTRHAAPKGGYREPGDDEGIPIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LK91</accession>
    <name>A0A367LK91_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_6396</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LK91"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="77" mass="9155" checksum="C2993FDCD474D53E" modified="2018-11-07" version="1" fragment="single">TRDLHLGHFRLSRRHVQPAFASHMPKAVTELTRESQPVRQFPKRNKNAIKKNTFVWLSSRQYIHDLCRRDVVPFTMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKM2</accession>
    <name>A0A367LKM2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7072</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKM2"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="138" mass="15492" checksum="7BF123BD71B56782" modified="2018-11-07" version="1" fragment="single">SQWGYSGHSARIDSLQRSSQRSARCTYSGHSTRLISAQGSRHIDRRAVLIAVIALDQSQIVRLIHNVKVFLQITYLPSVTYSHVILQLHHFFNTITSPAFNSSSILTKPPLRDSSSSSLLRDPHLDYSSSFPLPQITF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKV3</accession>
    <name>A0A367LKV3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKV3"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="99" mass="11418" checksum="75D17E2F5AA0869A" modified="2018-11-07" version="1">MPIPQDIIYKLAKKDAFYDITNALCSNAALIYYIPGAFNILADLLSRLLLKAAPEKGNRDLLFLEDADSRKRLCIPENCADKLISEYYLRKFYTGRRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LL27</accession>
    <name>A0A367LL27_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcriptional activator HAP2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_6369</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterotrimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NFYA/HAP2 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LL27"/>
    <dbReference type="STRING" id="1330021.A0A367LL27"/>
    <dbReference type="OrthoDB" id="1097733at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001289">
        <property type="entry name" value="NFYA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12632">
        <property type="entry name" value="TRANSCRIPTION FACTOR NF-Y ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02045">
        <property type="entry name" value="CBFB_NFYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00616">
        <property type="entry name" value="CCAATSUBUNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00521">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51152">
        <property type="entry name" value="NFYA_HAP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="237"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="41"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="275"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI15128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="335" mass="35618" checksum="35C26DF2A1713FB1" modified="2018-11-07" version="1">MEYAQYPQQQQNTNSGYASSGASAGITSPTNHSIGPHSVHSSPLLTSQTQQSQSQQSQSQSQQPQQQQQQQPSQQQMYQPQYGVPQQGMQQVPYGMPGIQAAAMAATAAASGSSYPYIHSDPSMSQSSPRMAGDSSKKDSRHSPRMNSLSQIPGARRMSQVSSPGMPSAAPGMVSHGGPRPGVAPPPIPPPGQPMQHPQSPEIPSGAAEESPLYVNAKQFHRILKRRVARQRLEEQLRLTSKGRKPYLHESRHNHAMRRPRGPGGRFLTADEVAAMEKDTKVEDVGKRESGDAVGAKAADSAGTKRKSEAGLGSPNKKSKTSANSAGDGGDADDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LL36</accession>
    <name>A0A367LL36_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LL36"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="244" mass="26730" checksum="BB5D83AC4BA02205" modified="2018-11-07" version="1">MAGAAKRGAAGSHRIDTSNRPTRGTDETPPSSRLSSFSLVANHFSFRPFSFTTLPRFPSPSFSPFGFLVSPRQRATIITCARLFLQLLIFPYVASVRAARARTLTHSFIHSSPSLSSPPRLAFVDAHLFLSFTPKRPSTVDAASIMTHQQLQLALLSSPCFSILTGKSSGRRMGQVGQRKRQEDRVHYAMAAVSPSTSKMLGRKKSIHAPVRRLTTVVCHGPRSRLDALVPPTPTGTKTCKSEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LL40</accession>
    <name>A0A367LL40_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_6428</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LL40"/>
    <dbReference type="STRING" id="1330021.A0A367LL40"/>
    <dbReference type="OrthoDB" id="18453at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000444">
        <property type="term" value="C:MIS12/MIND type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007128">
        <property type="entry name" value="PMF1/Nnf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15459">
        <property type="entry name" value="POLYAMINE-MODULATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15459:SF3">
        <property type="entry name" value="POLYAMINE-MODULATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03980">
        <property type="entry name" value="Nnf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="9" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI15154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="249" mass="27292" checksum="6712208D9220D87A" modified="2018-11-07" version="1">MAPGLKKRRRRREEDVGAQDDSEARAGMATQHAPPQRSPDPQQPAADDREEEDEAPGPRASRLRETYGLAVQRTLSKLSRENLARCYPSTASHAASMLADVQRQMVERLGARCQREFEMLLAARKVVCRLNGLERIVAEASSRREQAGGEEGATPPTPPHLLPPPRILAAHHASLLAPHQSVLNAKLQTCQAVNARLARVIRRQRADRLRLLARIHAANRDLVAANAALSPIVDHLAAEAREAASRTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLD2</accession>
    <name>A0A367LLD2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_6464</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLD2"/>
    <dbReference type="STRING" id="1330021.A0A367LLD2"/>
    <dbReference type="OrthoDB" id="9909311at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF70">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04218">
        <property type="entry name" value="CENP-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="4">
        <location>
            <begin position="232"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="55"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="309"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="426"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="568"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="116"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="323"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="378"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="450"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="482"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="568"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="581"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI15246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="608" mass="65964" checksum="DDC3D6A4F17B1132" modified="2018-11-07" version="1">MDGSAAMDQESVMAQCNGYGSDGWADLSAYHGPYDDGPIGDYTTFAQFMSSHGLSESINNQTQQQQHLQMIQPHPPPPPPPPPPHHHHHPHPPPPHMCHQQLPLLNTAWPSQLANPTPTSSSTGSYSAPPLPMTPAPTTPVATASSVVPPTTPGKGSRTTAVDLVKQPGQLEKLPRKTLSAEQKRAMCQYHDENPGTRQADIGAKFGVERSTVSKVLRHRDQYLKREQDADFAFKRAKGKNPDFDRTLSNYVRRQQHMGFDVKDEEIMEQARLFARASGNQEVLLSTLTGGWLHKFKLKHGIGSNNRLLRRASDTNVPDNVGSTINNNNKTTTPTPVSPSTTTTTTTQPLSPLSGTRSDEDLHRDTLEFELTYRAQGVGSTKRSKSPTGPSEACDGAVSAISPSASFSLSSDVSVAGFPPPPTLLPLTGEANLGDKRSKTFPSVDVSFMQKRESGEERGASSSTPRLGAKSSPCSPPPPLQLSPTTMTTTTTTTTTCVPPLTTTSPIPIAPHPCSSSSSSTSPPPPTQEEARRAANTLLFYMQRRGGQHFDKGEYGVVVQLAKKLQLQPRPRPQLQTQQQTHHHHYHHGGQRAPIGNLSRILEGDDYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLY0</accession>
    <name>A0A367LLY0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Subtilisin-like protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L249_6699</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9 10">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLY0"/>
    <dbReference type="STRING" id="1330021.A0A367LLY0"/>
    <dbReference type="OrthoDB" id="10256524at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02124">
        <property type="entry name" value="PA_PoS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07489">
        <property type="entry name" value="Peptidases_S8_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010435">
        <property type="entry name" value="C5a/SBT2-like_Fn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034187">
        <property type="entry name" value="Peptidases_S8_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF66">
        <property type="entry name" value="SERIN ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06280">
        <property type="entry name" value="fn3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0134">Cell wall</keyword>
    <keyword evidence="6 9 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9 10" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 9 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017050282" evidence="11">
        <location>
            <begin position="20"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="12">
        <location>
            <begin position="153"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="13">
        <location>
            <begin position="381"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="C5a peptidase/Subtilisin-like protease SBT2-like Fn3-like" evidence="14">
        <location>
            <begin position="615"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8 9">
        <location>
            <position position="162"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8 9">
        <location>
            <position position="211"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8 9">
        <location>
            <position position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF06280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCI15262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="893" mass="94106" checksum="B42D74D70AD54E82" modified="2018-11-07" version="1">MVRSAALLTLAAAAAAAAAVSAPAPNGHAGGLIPGAYIVELEQGGDHDTVLREVNQHGAARMQLDYKLFRGVSFQLSDMEDTPRKIARLAAMPAVRNVWPVRLYKAPNVRVEWTASESPVTAPPRLQRREKRDDFSPHVMTQVDQLRKRGVTGKGTRIAVIDSGIDYLHPALGGCFGPGCLVSFGRDYVGDAYNGSNTPKPGRTPMDCLGHGTHVAGIVAAQAINSSFSFTGAAPDVTLGAYRVFGCKGQVTNEVLIAAFNEAFEDGADIITASIGSPNGWPEEPWTVAVSRIVENGVPCTVSAGNEGDNGLLYASGAADGKGVISVASTDNMVTPTLLYRVSYSVNDGPNQGFSYVPAEPDAWDGVTMELRATSLDATVRNDACDAMPGNSTDFFNRVALVRRGTCTFAEKAANVARRGAQYILFYNNDAAGALATDLTSVPAVAAGGMVTKHVGEAWIADLRAGRRVVVKMASHHHAEQELVVQDNTATGGAVSSFSSWGPSWEMDVKPQFSSPGGNILSTYPLRLGGYAVLSGTSMACPLVAAIIALVGQVRGSLDPDMLGDVLSSTARPSLFNNGKNSSSYLAPVAQQGGGLVQAFDAAYTHTLLSPQGLSFNDTDHFASRVNFTVKNMGYKPLSYRLSHKPAVTMYTLAAGSIYPQAFPNDVVEGAEANISLSCETLTLSPGESALVEVEAVPPPGLDAERLPLWSGWVAVNSSDGRSFSIPYQGLTGSLHRSRVLASDAVWISRSTDKKSKPVPANTTFVLPAPGKAWQGVELPSIVVNPALGSPLQEIDVVSLALGGTTTTTPTKTTTTTGNDVVVKTIGQPSGYPSSWVARGVGATAWDGLLASGLYAPPGLYKFVVRTLHIFGDARNQSDWDVGESPFIRIQYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMB5</accession>
    <name>A0A367LMB5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMB5"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="134" mass="14935" checksum="D9AFD6B8CF54E922" modified="2018-11-07" version="1" fragment="single">MGRSNIIKSMTPGGAPIWQRREEEEEEKASSWVNNMLSSTCRQLHGPPRGLGLVVDSSPTQLYTRPPLLEASTPSASPLALLPSPPRKRILLLSHHVHYDGWALARSAVHFRNLRRKMHTASTLHTTYHLLTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMG1</accession>
    <name>A0A367LMG1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PWI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_3424</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMG1"/>
    <dbReference type="STRING" id="1330021.A0A367LMG1"/>
    <dbReference type="OrthoDB" id="163257at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036483">
        <property type="entry name" value="PWI_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052225">
        <property type="entry name" value="Ser/Arg_repetitive_matrix"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23148">
        <property type="entry name" value="SERINE/ARGININE REGULATED NUCLEAR MATRIX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23148:SF0">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00311">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101233">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51025">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWI" evidence="3">
        <location>
            <begin position="12"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="106"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="106"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="242"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="294"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="312"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="349"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="391"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI15442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="452" mass="51850" checksum="02DC41F31F2EB607" modified="2018-11-07" version="1">MASKMDARLLKSTKFPPEFNQKVDMEKVNLHVMKKWITKRISEILGNEDDVVIELCFNLIEASRYPDIKSLQIQLTGFLDKDTATFCKELWNLLLSGQSSSQGLDADRVANTRLSRDVQGPDDRERRDSKPVTDSWHAQERRADRAFSNRSRGSHHGRGGPRSPSPGPRGRGPRQSYGRDSYVPSPRGRRAPAARREQDRSPLSAGSSRSRSRSRSESHGSRRSHSPPRRRPSPARQEPTRKRSRSPRHARRGKNSRDRHQSRGRSRSSSSERMSPAAKRKRRPRSRSVSAGRFFRRRYSSSPRSRNRRDHRSRDRSREPDRYYRRRESPTDRQRGRRSLSPEHDYDHGRHRGRGNGRRGMPRQIRKGGHDSSRRRRNSSSDSSLSPIRGKSADVLEDDLRASSHNPTAPNENTFPESSPQEDSVLREKLLREKILKMRPSNQSGASADGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMP3</accession>
    <name>A0A367LMP3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_3525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMP3"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI15661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="108" mass="11788" checksum="85ACFD4D249C4CAA" modified="2018-11-07" version="1" fragment="single">MRWNDDDERKGGCRDEWRLVLLTPPPLSSLLQPPTFRLTNHNKQKSQNMGKTPPFFNNRLAILVGGTRVMTPSVGTGSLADSGAMDVERALSKGEPTAMVAQPIASDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMP9</accession>
    <name>A0A367LMP9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMP9"/>
    <dbReference type="STRING" id="1330021.A0A367LMP9"/>
    <dbReference type="OrthoDB" id="5578001at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="376" mass="40763" checksum="50EFB9EC7E09D600" modified="2018-11-07" version="1">MGVSILLPDRAALLAPVLPALPAAAAATRPAIRLLPLLSPILRQRVQLLSESSSEPWLRLLCYDSEKTARLMDIAHGDSLQPHPVSGEVEIDWGYDAETRYRRLDEETLQALVVIADLSLAFLLAYCVGDQVGGGDGWRIAEVTVTDTPLPFERFGGATTIVDAERQFEQSHGQNTTLTAVGGGGGDDDDDDDDDDDDDDDYWGRYDATPGRTPAIKECRSSGLSLTASAEDEYYAQYDQVQPAMDSHDADEELAGTQVALPLGLGPSKTEPLCLKTEVTVQGRVVASDIGGHSPDDILSPRPESSVDSNVCDTVARLEESADRQEQNEFGVRQHVARTIRSLYLLSQSTGIGRQEFRCMVETELAVLGMVEGDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMZ7</accession>
    <name>A0A367LMZ7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMZ7"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="76" mass="8182" checksum="C616426F7009CC5E" modified="2018-11-07" version="1" fragment="single">RERQTLLHTQGTRPEGLGGSRDAGPATAGPRPLYVIEAEAAMPYSGYGRTGCTGRIKEGTIRQARRAFFSNTISLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LN49</accession>
    <name>A0A367LN49_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_3529</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LN49"/>
    <dbReference type="OrthoDB" id="3936451at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF96">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="14"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="30"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI15672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="356" mass="39225" checksum="5A9FFA6DE60A5F06" modified="2018-11-07" version="1">MQGPNISTTATRLFGVQLSLLIVCVIFTSLRVYVKSCIARNMAAEDWIIVLATVIFALSIAIAMRGTTFGAFGQAKSGTASTTERIVATFQDLYFCEVLYSPTSLAIRFSICLFLLKIVNHKTHRRIIYLLLAVVSSASISYWLITIFQCVPPSFFWSQHQPGAVGHCLHPEAFFYAGYVHGSVSAVSDLVVGALPIAILWRIRLDRRTKLTALVLLGMSFLNTAIWSIIESAIGIVAASLPTLRPLFRKWPIRPRSDKTPIPKLVLTSRRSRPLELISRWVELTAHNSSDEACADVVLADIEPVSSMVRQCNVTIERGRLPETAPSGGISIHTAIEVKTQPRDSVYDGPGLSPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LP13</accession>
    <name>A0A367LP13_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Small ribosomal subunit protein mS33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_2359</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LP13"/>
    <dbReference type="STRING" id="1330021.A0A367LP13"/>
    <dbReference type="OrthoDB" id="2257454at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013219">
        <property type="entry name" value="Ribosomal_mS33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13362">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13362:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08293">
        <property type="entry name" value="MRP-S33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI16173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="107" mass="12384" checksum="DABC60809447ED99" modified="2018-11-07" version="1">MSVPRARLLDLMKAQCQIFATTYNPDGVRMGNKVLRQRLKGPALAAYYPRKLATIKDVKREFGPHLTTWDEDEEDRFDYIEELKERGKSAPKKKRTAPVINYGKKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPF7</accession>
    <name>A0A367LPF7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_1855</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPF7"/>
    <dbReference type="STRING" id="1330021.A0A367LPF7"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF237">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ATNE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="457"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI16290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="538" mass="60501" checksum="9CB5BEBB5A573793" modified="2018-11-07" version="1">MIGTYHHHLYASPVVYAAVVLVFLASVIFRRIYFHPYRHVPGPLLAKITSGYSAWHSWRGSMHLDVQRCHERYGTSLPWNNILIQIQSADAGTNRRPETKAIYGHGAPFRKSKGYATMCPVPGGWTTMTSIDKPLNQRLRRVFRAGTGAKQLAKFEPAILRRLKICLDQLQVDNGWSRSADMRRWSLCLGFDTMADFGLGIETNLLRSSDRDFVFPPLHFHEKKLGLWEQLPALNNVGLGILVSAAYPVVSPKARRFYKWCLDFLDRASERNRSESRGIFGPVIQSGHGNLSPAGHNRAQMMGESFFSVSSSAEPYAILLSGFFHYLGHYRQVYERLAGEMRSLYGPGEDIVWDAKLESNVYLRAVINELLRLLPPACGVHWRECEAPGVSVGPDQTPVSVGSDAGMSIFSLFRDGRLYREPLRFWPERWLPGVLPEDEFRTAKKAFTPFLIGPRNCAGGHISIMMASIAFAYTLVNADFRLGPEQADLVRRRSETACRHVGAEFELAFASHSSITCWESGPFIQFSGRATEKSVLPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPJ3</accession>
    <name>A0A367LPJ3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_3163</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPJ3"/>
    <dbReference type="STRING" id="1330021.A0A367LPJ3"/>
    <dbReference type="OrthoDB" id="1908178at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF17">
        <property type="entry name" value="OS12G0638900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="260"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI16329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="568" mass="65741" checksum="86AC83AE731EBB52" modified="2018-11-07" version="1">MRIHSRLDSRALLSAGRRNTHVVASPARPRACPQSSVWLRSTFLSPSLPGQFRRRRLRSCRSSASRSPPKPIDRQYLLSLVGGEYDESVDQLFDFYRDPYRRGYALPDGPKVRVSDKKSDVQYPSHGETARGDENEWRLVLQLYVAIGQRLRNPNRISLDSIYKIYRRLSEPRMLLLSWHWRSRLMRVMGTPQRRNIESMLRYFALVADVKNAGLTLRLSEWNYALSLSARYTIRSTYREVESTLRLWREMEREAHVRGNEVTFNILFDVASKAGNFTLADMVYREMESRGIEFNRFHHVSLIHFFGLKLDSAGIRAAYREMVESGQMIDTVVLNCVISGLLRCGEEAAADEVYERMKGNHTLAAELPSRNYMLNRVISKVLLMFSKVSRRYPELKNPLQARVHLSPDLRTYKMLVRHHAIRLGNINKVAQYLDEMKGLVIPVHPTIFLALFKGFYLYGGFPGSDWSQTRLDGVLLALYQARDTHANDFPIYGWLVIWVLRAVKRCSSTEAVAEAFDELNRRWDVPADRQAVMFQIYDSIRTGRDLTAPWRMKNGMAHGRGIRDGAWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPY2</accession>
    <name>A0A367LPY2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cdc23 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_2084</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPY2"/>
    <dbReference type="STRING" id="1330021.A0A367LPY2"/>
    <dbReference type="OrthoDB" id="10262026at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007192">
        <property type="entry name" value="APC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF10">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04049">
        <property type="entry name" value="ANAPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cdc23" evidence="9">
        <location>
            <begin position="10"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="371"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="405"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="568"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="568"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI16469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="681" mass="75154" checksum="A06809B7C1327CFA" modified="2018-11-07" version="1">MTLSAQEVGQLREALQDAVIKCSERCLYQSAKAAELVNALPDIEDADQDLDGKHVSPAFNPNPDPDEAALEARELSKYLLAKSLFDCKEYDRCAAVFLPESVLSSALASHSDAAVGSSSRRAKGKGKATASPRTAPLPKMSQKSLFLALYAKFISGEKRKNEDSEMVMGPQDLGSVVNQQLLVIGRYLAAWFDERTVDSEEVLGSQGWLEYLYGMVLAKEKNDAKAMEFFIRSVHKYPMNWGCWLEMTSLIARVDELNRIARHCPQNIVSFMFHLHTSLELYQQSPSLANSLEQLLSIFPTSSFLLTCNALLAYHAKDLIAAEQHFSRLLSLHPHRLDSLDHYSNILYVLNLRPKLAFVAHLCSSVDKFRPESCVVIGNYYSLLSMHDKAVQHFRRALTLDRSCLSAWTLMGHEYVELKNTHAAIESYRRAVDANRRDYRAWYGLGQTYEMLEMHTYSLWYYKKAAGLRPWDGKMWLAVGSCLNKMGRERDGIKALKRALLAEAYYEAGSSFGNGGDIVGGRGATGQMDPDILLQIATMYDQLDEEEEAKAYMELCVAQEDGGAAAATGGGGGGGGGGGGAGDSVVVPNESLAGSDDDPDRHDNVEGTGVTAATSKARMWLARLAMRTQDYTTASRLATELCQDGVEVEEAKALVREIRSILDSAGGQFYIWFRNSDGLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQ33</accession>
    <name>A0A367LQ33_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glycerol kinase</fullName>
            <ecNumber evidence="3">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_2784</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQ33"/>
    <dbReference type="STRING" id="1330021.A0A367LQ33"/>
    <dbReference type="OrthoDB" id="5422795at2759"/>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF69">
        <property type="entry name" value="GLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="10">
        <location>
            <begin position="36"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="11">
        <location>
            <begin position="263"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI16555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="505" mass="53575" checksum="FE6294C80D2A39DF" modified="2018-11-07" version="1">MGDKIRANGDESAFVGSIDQGTTSTRFLIFNQAGERHDPLELLRSVETCIQHAVSDFRASGHHTAQIRAIGLANQRETLVAWDTATGEPLCDAVVWSDTRTAPLVRELKARDGADVLVHRCGQPPSTSASAIKLLWLLCHVEAVARAYDAGRLAVGTVDTWLIYRLNGGVRRPGGPIYVTDSTNASRTMWMDIRTRQYDHELLSFFGVDRAKLTLPTIVSSSHPTAFGALAYGPLAGTRIAACLGDQSAALVGHGGFSPGKAKSTYGTGCFLLYNVGPEPVISKNGLQATVAYDLGDGRPPAYALEGSVSVAGSGINFLVNNLDFVDSHKAIDHLALSVPDNGGVYFVTAFSGLLAPYWIDDAQGTLFGLTAHTQKGHIARATLEAVCHQTAAILDAMAADSGHALDSLAVDGGLAGSDVCMQTQADLSGIPVDRPCMREATSLGAALAAGLATGVWDGLDQLVHVGTSGRSLFRPGIVKEERCARRRRWARAVEMSRGWLAEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQ39</accession>
    <name>A0A367LQ39_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="7">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_1907</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="7"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQ39"/>
    <dbReference type="STRING" id="1330021.A0A367LQ39"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17920">
        <property type="entry name" value="DEXHc_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF120">
        <property type="entry name" value="BIFUNCTIONAL 3'-5' EXONUCLEASE_ATP-DEPENDENT HELICASE WRN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="91"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="299"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI16538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="747" mass="83401" checksum="DBADB3B7B21D1EB6" modified="2018-11-07" version="1">MSDAEFGSGDELFADLDSDFEFGADDELFDGGEELLAAIDAQKRKQFYEDEDPDIPRKRHKVYESHAAVALSILTEKFGHASFNHQQEAAIASVLAGKNTLVIFPTGAGKSLCYQIPAIAFEELDKLHGPRTSGQSGISIVVSPLIALMKDQVDALQKRGIPVDCMNSTKTYEKEQLTRLAMQKGQIRLLYCAPERLSNESFIENIKTVPGGVRLVAVDEAHCISEWGHSFRPEYLKVARFVEEINAERVICLTATATPRVADDVSKAFKIDCSSIFRTSPYRPNLHLHVEPVEVKHDKYERIFKFLRTHSGPSLIYVTLQAVSTISLPQAESLADDLVRQGFRAVAFHAGMKAEVKQEIQDDFMADKIPIICATIAFGMGIDKQARDIRNIVHLDIPATVEEYTQQIGRAGRDGKISHCLLYLCHEDFYLRENFARGDLPSRRSVKALLEDVFNKETALLSPVDGVITANHYAQSRDFDIRPSPLSIIYASLELRFGLIRAITPEFTQYYFEATNEYEKVIKADGSKEAKAILANARKKAKYHYLDMPGVVNGTGLLRTDLVRKFNQLEERGCIKLKTSGIQHRYRILKPVPTTEKSFAKLLDELYADLEFREGEALRRVHQMAKLATESKCLALALAEHFGMGLPDGKTNCGHCTFCISGRRVVMPPAPPKPLDKGGIEQVLQACDVRDDARFLARVAFGIKSPRVTQLKLDRSPVFRSLANHDFGALLTIFTAVCEKEGADVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQN2</accession>
    <name>A0A367LQN2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Modin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3014</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQN2"/>
    <dbReference type="STRING" id="1330021.A0A367LQN2"/>
    <dbReference type="OrthoDB" id="5227693at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="480"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="624" mass="70863" checksum="0DAE18FBA0FC23D4" modified="2018-11-07" version="1">MAGSEPELFVAIAALVVSIVALTATFMQVIQQYYASASGYSKCNERVMGGWAKSKCRRFSWDELRYEVQFEAPVIFVSPPSNKDGPVPNAPIRVLDGTDESKKDTDTTSNSDESKKEKAAKERIHTADNETASWLLLLNAIQDMEAFSREWQSEQYQIQGPPVNHRPPKPPAFKDHHTLAVAVQRKRRTWDTMPSSVSRPYATTTICHLVEMMAVLGVYWKEFDRNRDRYRAEGNGFVLMGERLPDLGLIFSFQLYGMFSFGDNRVIPVDDVKELCFGFVPTIYRGKVNRRRLVAEPPSFGYLQMATRRDISETLVAAIGCNKNTTQRFTDEGGKTAHLFPLSFEILGMIAVTFHINNSCFTCLPNPTPDRWKKKSFSLRKILEAYRRFFEEQPPNNLAVNKRIAQHIQEILSHQENAAGVARLQALHSALDDTDEVLRARANSLTNSSDGNLPDSPQQLRRQMVQDVLRSHIQEVVRLLNESPSTPNSPQMSRFEDIDEASPNDGNDVFMKLYFEVVRQQVVKLAERCAKRRDSFSPWRPGNGRGRTAAQTAANGLEDSEVTPESPDGREMPSLADERVSYDDVWCVLIFRMICWLMLHDFDERDVQVNKSELLGSRMPVYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LR32</accession>
    <name>A0A367LR32_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_2720</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LR32"/>
    <dbReference type="STRING" id="1330021.A0A367LR32"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="4">
        <location>
            <begin position="49"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Thioester reductase (TE)" evidence="5">
        <location>
            <begin position="722"/>
            <end position="959"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI16903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1088" mass="118848" checksum="DACD6528387E0FD3" modified="2018-11-07" version="1">MLAPQLNLGQSGLDPAMRRQRVASDLSSRGQSPANRYGHRLLVDVVEGTAKRDPTRAFVYQPRTSNPKDGWHPLTYREAVNAINKLAHTITRELGVPAKNSFPTICYIGPQDIRYMFFLIACVKAGYKALFNSPRNSLEATLSLLKVTDCNALFYAESQAKIVEPWLKNREMKHYVIASTKDLAQSEPEPFPYNKTFEEAVWDPLVVLHTSGSTGIPKPIIVRQGSLAVADAYRNLPEMHGAKFYLADYKERCTLYFRHMPLFHAASVYGFLCGVIYYDIPMAFGCPDSQLTASHVMDCFKYSGADAGVLPPSIIEEMSTTAEGIATLKKLSFVVFGGGPVSPVVGDMLAKQGVLLVSAIGSTEQYPYAMYFQPSAANWQYFIFDAEAMGADFRPIDGKGSPEELVVVRKGGQSKFPSQSVFYTFPDKTEWSTNDLYLPHPELPNHWTYRGRIDNIIVFSNGEKLNPTTIEDTITGHPKIKGAMVVGQGRFQSALILEPYENPESGEEAARLTDEIWPLVDQVNKDTVAHGRVGKDFIGYSRPDAPFPRSGKGAIQRALAMELYKDDIEELYDRALSGEAGGPVTLDLTDEAALANCIAQLIDSRLGVSGLAPETDYFDAGIDSAQVIRIASLLRAGLKDMTLPNNMDLQEVVTPKQIYANNSSQMLAGYILGVVSGESGSGQEQARGIKVMEQLLAKYTLNLPPPVAGKPKPKDEGQTVVLTGTTGSLGAYMLDMLCNSPKVKKIVAMNRGADGGRSRQAGVSSDRGLGTDFSKVQFVGVDVSKPSLGMEEEAYRQLLSEVDRVIHNAWSVNFNLSVGSFEPQIRGVRHLVDMVAAAAKQAPIAFLSSVGSVGGYPDKHQQVPEVKLDDLAIPVMGYGRSKALAGLILDAAAAQSGLHTAVVRVGQVGGPRGEKGCWNKPEYFPSLVASGLHLGILPEDLGPRQRVDWLTMEEVASTILEIVGVTTDVDVDDISGYYHASNPRASSWREMAEAIKEFYGGRIERLVSLEEWQETLEKSGEEASDADLEVNPSIKLLESHRDVLRGKRAGAPPTVLATERTVGVSPTMRASKAVTPGMMQHWCKQWGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRD5</accession>
    <name>A0A367LRD5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_3070</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRD5"/>
    <dbReference type="STRING" id="1330021.A0A367LRD5"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009725">
        <property type="entry name" value="PRK13252.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="74"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI16979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="562" mass="60547" checksum="889E7B05B0912D50" modified="2018-11-07" version="1">MPPSLSLRHGLPRSIHCIDHRRQAAYPGAGPLSRVIVASLTFSLAPQQRRSFAMSLPSEIHTFHSGSTHPETSDSKATFVSLDPATARPLATIFTTTPRQLDDAVAAARAAFPEWSQTPAPRRAEILLRAAAILRQRNDELALTETLDTGRALCETAAVDVLTGADVLEYYARLVADSQPGHHTRLRSDAFILTSHEPLGVCAAIGAWNYPLQIALWKSAPCLAAGNCLVYKPSEVTPLHAETLAFIYREAGLPHGVFNVVYGDGPSVGAPLVAHADIAKVSFTGQVSTGCAVASEAARRMKSVTMELGGKSPLLVLPDADVDEAADVAMAANFFSTGQVCTNGTRVFVPDTLLASVEEALVARCRNGIRMGIPREERTNFGPVVSAVQRDKVRSYIRHGREVDGARVLYDGAVDAQKSTPTTDGYWVAPIIFADCTDAMRIAREEIFGPVMCILPYKTRDRPQDEWLPELIGRANDTHLGLAAGVVCSDLALAHDVVRQLQAGITWINTWGESPAEMPVGGWKMSGIGVENGHEGIRAYTQTKSTLVQLGKGACKDMFPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LS71</accession>
    <name>A0A367LS71_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2465</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LS71"/>
    <dbReference type="STRING" id="1330021.A0A367LS71"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI17293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="398" mass="45832" checksum="5EBF8B721F5D802A" modified="2018-11-07" version="1">MSSVSSDGRPTFFSSSSPEPDLTSVSSEPDPSFESPSPISPTPYPSPCETLQGLRPDRMDYEDYGYDFENNSDFDDDDDDDDDDDNDNDDDDNDDDDDDDNDNDDDDNDDDDDDDDDNDDDDDDDDDDDDDDDDDDNDDNDDNDDNDDDDDDDDDNDNDNDNDDNDDDNDDNDGKGNNVHNNDNDVHDYDENENDDNVHDFDYDNGNNVYDFDYDNGNVYDYHYDNGNNVYDFDYDNGNNVYDYHYDNGIHDHNYDDVVDGVSYVSPADIMAPPTMTAPYLNDAMDFHSYQTPFVQVPQAEEQHKENAFDFLHQDTAPANTSQQERPHRQVNASRMGHRRRRLRTCCRASRERRHRRDATLFFTERFFCVTERMVDFSTSVRAYRQRRSAGTGGDGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LSA1</accession>
    <name>A0A367LSA1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8035 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_2467</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LSA1"/>
    <dbReference type="STRING" id="1330021.A0A367LSA1"/>
    <dbReference type="OrthoDB" id="5226662at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058348">
        <property type="entry name" value="DUF8035"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42081:SF2">
        <property type="entry name" value="NIPPED-B-LIKE PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42081">
        <property type="entry name" value="ZINC FINGER PROTEIN DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26118">
        <property type="entry name" value="DUF8035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8035" evidence="2">
        <location>
            <begin position="368"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI17291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="628" mass="68883" checksum="CB61930A061D1AAF" modified="2018-11-07" version="1">MSDSASLRHIDAVDAFSRTLFLRAQQHGAHPLSDIPPAVHQLHIALRHLRIEAADPDSLLNQGPDQASLAPRVQPLVRECEASLKQLESLLDKCDASSSGRRLDDLVDRAAAVRVRLDNDTATVDMLLDSVQLPSVSDRIVAGPDVERIKDKVDAIAASIFARHDDANVDEDGLWRDFKSDLEKDGFSPQVLHHHKEVLRAYIRELHHTSSRTGGAPPSVRGLLEKHQAKGPPVPPKEPIRSPAPDALYLPPPSSLLFSSTEDANAMTESTALISTKDLVTTNSLVAASHLRPQVQPLGSTPRSVQRDLPTPTSAATRAESCTNPSLLGTSPSYGGHNLYLQTPQGHSPTQMPWRLAPDRFGKDIPMDAQWTKIRRSLVSPEVLERAGVRYEARPDFVAILGCLSRAQIVEFAEQSAKCRASRSHGGYMSGRQEVRPRSDSKSSRGEDDDDDDDDASELWDEGDSTDYDDKSDNSYPYIVSPPSKEKKTSPASTVMPKSILKNKNENHVRFDPEPHELQPKSPRHGKDEGEGGGDYAPRRQRHYRDREGSGRSRNGNGREGDRYGSSSRHYGSDDGPRRGGSDRDRRGPRRDERSQRKKVWGETLGVVGIGGAAASLIGVLTEAAIGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KYW4</accession>
    <name>A0A367KYW4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_3783</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000035">
        <property type="protein sequence ID" value="RCI07363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KYW4"/>
    <dbReference type="STRING" id="1330021.A0A367KYW4"/>
    <dbReference type="OrthoDB" id="4509994at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI07363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="97" mass="11036" checksum="D4858DFC7F01E1EF" modified="2018-11-07" version="1" fragment="single">KIRTNKATFRDEEDRIGFLFRSLKGKACKTLETYLLTKTKDDSLSYEDFCGYIKDSAIKRLDAKLVLPNDLPALAKYSLSILLPKTPLLNRQIDPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KYX4</accession>
    <name>A0A367KYX4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_3771</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000034">
        <property type="protein sequence ID" value="RCI07366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KYX4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI07366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="75" mass="8614" checksum="DAF953A25F6688E4" modified="2018-11-07" version="1">MTARDELPTGIQYEFCRFISIRSSYETMEYLKVKVTEVDANSFNTNNKQVPGKTDPEHAAMIANSPILNMVYHQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZN3</accession>
    <name>A0A367KZN3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_1656</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000026">
        <property type="protein sequence ID" value="RCI07617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZN3"/>
    <dbReference type="STRING" id="1330021.A0A367KZN3"/>
    <dbReference type="OrthoDB" id="20681at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1230.10">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036748">
        <property type="entry name" value="MTH938-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007523">
        <property type="entry name" value="NDUFAF3/AAMDC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21192:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX ASSEMBLY FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21192">
        <property type="entry name" value="NUCLEAR PROTEIN E3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04430">
        <property type="entry name" value="DUF498"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64076">
        <property type="entry name" value="MTH938-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI07617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="24104" checksum="8040891866B4B86E" modified="2018-11-07" version="1">MRRVIERHLRIATRDPVRCTTLWCSNSVPLPRPWTSVASNYTWRWMHATAGWKKQDSPPSEPPTTDFNAMNMLNNTPIPSTSVDVCFYDGFGLNSGITISGGNGAVLVGGQAFVWRPWQINGAMKLVNEKGQFDLPKVAFGLFEVLWPRPDLLIVGVGKHNLPLSPMTKQHITSLGIRVEVLDTRNAAAQFNLLATERGVSEVAAALIPIGWREGVGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZP6</accession>
    <name>A0A367KZP6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5901</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000025">
        <property type="protein sequence ID" value="RCI07663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZP6"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI07663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="86" mass="9886" checksum="7C045BF18D4DD632" modified="2018-11-07" version="1" fragment="single">KIRTNKATFRDKEDRIGFLFRSLEGKACKTLETYLLTKTKDDSLSYEDFCSYIKDSPNNLPALAKYSLLILLPKTPLLNRQIDLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0I7</accession>
    <name>A0A367L0I7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5842</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000023">
        <property type="protein sequence ID" value="RCI07938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0I7"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI07938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="106" mass="11644" checksum="1DECCD0555118A25" modified="2018-11-07" version="1">MRHNLSTCIFSYIHRLATGQLSHNAGLFEANPDLRATAHGDIVLAHGYLNFPPARANRLGPPPPPPPPPPPPPPPPFFLLRSDSLTPQSLSRTVSSPCFHLHLAWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0M0</accession>
    <name>A0A367L0M0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_7877</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000022">
        <property type="protein sequence ID" value="RCI07964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0M0"/>
    <dbReference type="STRING" id="1330021.A0A367L0M0"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF28">
        <property type="entry name" value="ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="60"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="456"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI07964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="554" mass="59703" checksum="DB15E7B13DC4114A" modified="2018-11-07" version="1">MIRNPPLYCIGPRAGLLPTVAFFSMLHARETGYERRLAAPTLLASGLLFWSRTAMTLSALTLLASLAAGSVAVPLSAAFPAPELQYILNHSEASLLVASTKLAAKADEVLATDLSSRPVHLHLEKHIVGETPDKLVSLDSGAEAAAAAAAASLMLYTSGTTSRPKGVVLPHTVLEAQSRSLIEAWRYTPTDRILHVLPLNHIHGVVNALITPLIAGASVEFMYPFNADAVWRRLATPFTSSSDNDTRWSQPVTLFTVVPTVYSRLLVSHRSLPPDVGEAARDAVSPANMRLAISGSAALPTPIKAAWRDLSRGNVLLERYGMTEVGMALSCGLDFADRVDASVGWPLPSVQARLVDLDSGRPVAEDVLDQPGEIQLRGPTIFSQYWRNPDATARTFVTDPDGGQPWFRTGDVALRRAVPTAGLNHQSWAHGPVFFVQGRVSADIIKTGGEKVSALEVERELLSLPEVAEVAVVAVPSGNWGQKVGAVVVLDREVVQKWTPLDMRRALKGRLAGFKIPQTLKVVDSIPRNAMGKVNKKDLVRAVFADEFSDDEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L122</accession>
    <name>A0A367L122_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_6333</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L122"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11482">
        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF4">
        <property type="entry name" value="ALLANTOIN PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="400"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="492"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="540"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="541"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI08139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="565" mass="63179" checksum="628808B2B4BE1620" modified="2018-11-07" version="1">MKTSSLFRRFELEDVSSLTNDDVRPCDVKRRTWNLLAFHNYWLLINCTIATFFAGSSLISFGLTWWQAIICIVIGNLLVTAAILVSSVQGTHYHIGFPVYSRAVWGIWGSQFTIWNRIFLSFVCFIYVKYGFQAWVGGQCIYLMILSWDPQYESRIPNGIPAETGMTTARFVCYVIFSVISLPFIWLRPHRLQGFFNVTSAVTFIFFFALLVWALATMGPAGFGETIESSQPGMTSDDMRVPRTTGWRMAYAVMATMGSIAAGILNQSDFARLARRPRDAVIGQALAYPVYAIYTSVLGILVVAATQRRFNGEAIWGLPTLFERLLERDPGPDTRAAVFFSGLALVTSQLGSSIPGNAMAGGIDLASIFPRYLNIRRGAYLTALLSPIFNPWRLVTTATVFLSVLNCYGIFLAPMTGMMTAFYFVVCRGKLKVEDLYRAEHDGIYWYWRGVNWRAPIAWVIGVAPCLPGIVAQLTGNQSLPESAMELFSLNYLYGYLVSGSVFAALHWLFPARPVDDFVRQPETARQLQQHYRSLWDEISSEPSNVSGGMSFQGKEPPSNGSNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L188</accession>
    <name>A0A367L188_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_7811</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000022">
        <property type="protein sequence ID" value="RCI07982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L188"/>
    <dbReference type="STRING" id="1330021.A0A367L188"/>
    <dbReference type="OrthoDB" id="2117972at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045464">
        <property type="entry name" value="Hrt3/FBXO9_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12874:SF9">
        <property type="entry name" value="F-BOX ONLY PROTEIN 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12874">
        <property type="entry name" value="F-BOX ONLY PROTEIN 48-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19270">
        <property type="entry name" value="FBO_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="3">
        <location>
            <begin position="173"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="F-box protein Hrt3/FBXO9 C-terminal" evidence="4">
        <location>
            <begin position="271"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="35"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="130"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI07982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="457" mass="50141" checksum="3B7A2F817C9F69D5" modified="2018-11-07" version="1">MTSSQRGLDSELESFRQQWLSDLRTRCGGAESCSSVAAATPPMTCADDVGGDDVDEDTDDFQGEGRGDGSVFASPSPNLTGDTLVSALDFYEAAMEKEVDGNMGDSLKLYRQAYRLDPSVDHRYREKHPPAPPPDTAPVPTPPPQFDSAADLIASFASLTIVPLAEASSSCPFASLPDELLVLILSEVAASDPGVLTSGAALACKRLAYLSATEQRIWRRVALSPLYGFPAMHYRFCLDDNWHALPDLDLHHTRHPGSPVSCAALIPSTYASWSDMFRRRPRIRFNGCYISTVNYVRPGHHSASAAPAAWAGSSPVHIVTYYRYLRFFRDGSLISLLATVHPADIVHQLTPDQLRLHRHADHSHSTQNSPMRLALRGRWHLVADDEDGSSLLVETEGVGPKYLYSMHLLLRRAGRAACNNKLVWKTFHSYNKLTDDWAEFGLKNASPFSSAASRATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1X4</accession>
    <name>A0A367L1X4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">B30.2/SPRY domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_8913</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cclA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1X4"/>
    <dbReference type="STRING" id="1330021.A0A367L1X4"/>
    <dbReference type="OrthoDB" id="10266026at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12872">
        <property type="entry name" value="SPRY_Ash2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037353">
        <property type="entry name" value="ASH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598">
        <property type="entry name" value="SET1/ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598:SF0">
        <property type="entry name" value="SET1_ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="5">
        <location>
            <begin position="145"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="516"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="537"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI08414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="548" mass="60473" checksum="67CE6C7AF36606B5" modified="2018-11-07" version="1">MSSDVDPPKAETMPPASLSSIPQKRSLDEGHSPAVSSPLNAEVKPQEDTSHPPGRPKPSRAKKDSLKKREAKGADSGPATPDTKLPSRDQKPADSAPLRYKLAPPKSSDFELARGPILTPHHQIVAPDGRTIEFLETSEHVFNKKNFRYTHCIADPLFRSIIYYRQTEPEPFGPRLSFEDAATHVFFDRSALHITTDKGFRMARANVAVREGRWYWECRILQGVIPPQDGSSRPQGGKHIRMGWARREASLDAPVGFDAYSYGIRDVSGEKVHMSRPKEFFPPGEGIREGDVIGLEIQLPSEHLHRKVMSGDFNPAVDAADDEPALAAESLNIVRDRVPIRFKAHTYFEKIEYHSTKELEDLMNPSPMATGLSVIQAPNPNHPSPALRTLPNSCIRIYKNGVLMGTPFENLLGFLPPASRPMPQVGAREGLDDGMLGYYPAVSVFRGGAAEVNFGPDFWYPPPECDSTNGEVDMIPTDEPQQARVQAVSDRYTQQIAEDIVYDIIDEVDFWIMDGGGATSDPGDAQGTSAATVSGPGREEIKELVQDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2M6</accession>
    <name>A0A367L2M6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Importin subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Karyopherin alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">L249_4871</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the importin alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367L2M6"/>
    <dbReference type="OrthoDB" id="5600252at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23827">
        <property type="entry name" value="RWD_YLR419W-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.690:FF:000003">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000021">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.690">
        <property type="entry name" value="Importin-alpha, importin-beta-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032413">
        <property type="entry name" value="Arm_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056328">
        <property type="entry name" value="DSRM_DHX29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002652">
        <property type="entry name" value="Importin-a_IBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036975">
        <property type="entry name" value="Importin-a_IBB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059023">
        <property type="entry name" value="RNA_hel_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032566">
        <property type="entry name" value="Znf-C2HE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16186">
        <property type="entry name" value="Arm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24385">
        <property type="entry name" value="DSRM_DHX29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01749">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26026">
        <property type="entry name" value="RNA_hel_CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16278">
        <property type="entry name" value="zf-C2HE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51214">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IBB" evidence="17">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="11">
        <location>
            <begin position="124"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="11">
        <location>
            <begin position="166"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="11">
        <location>
            <begin position="354"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="14">
        <location>
            <begin position="844"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="1163"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="1424"/>
            <end position="1591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="573"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1097"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1764"/>
            <end position="1785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1765"/>
            <end position="1785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00075820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RCI08674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="2122" mass="234757" checksum="B4409EE5F22C1FA9" modified="2018-11-07" version="1">MAERYIPEHRRTQFKAKNAFKPEELRRRREEQQVEIRKAKREENLAKRRGIGTGENRPGASLGAAPDSDDESAPTESQLNEDLPQMVQGVFSDQIDLQIQATTKFRKLLSKERNPPIEEVIKTGVVSRFVEFLRSPHTLVQFEAAWALTNIASGSATQTQVVIEAGAVPIFVELLGSQEPDVREQAVWALGNIAGDSPHCRDYVLSCGALKPLLNLLGDSRKLSMLRNATWTLSNFCRGKTPQPDWNTASIHLKLPVATIAHLTWLQIAPALPVLSKLVYSLDDEVLIDACWAISYLSDGSNDKIQAVIEAGIPRRLVELLMHASTSVQTPALRSVGNIVTGDDVQTQVIINCGALPCLLALLSSAKDGIRKEACWTISNITAGNSSQIQAVIDANIIPPLIHLLQNGDLKTRKEACWAISNATSGGLQKPEQIRYLVSQGCIKPLCDLLSCPDNKIIQVALDGLENILKIGDLDKQSAGEGADSINRYALFIEECGGMEKIHECQNNANEEIYVKSYHIIEKYFSDDAENDEGMAQPTGANGTFGFGANGPAQTGGFNFANGGDSMDIRKSMVKKAKDKADQPTAGPSKRTKDGGKGKTGRKATEPAATTTPAVPPPKPTVKQIIGGSSWTGKLPVNLLSEHCQRLRWEKPEYDTRKTPDGFSVWVTLSARDAKTQQLTRLEPFKIPASHKHLLLRETALEAKHAAATYALFRVCNMQNKHTVLPPDHKSLWKEFQALKTQDAKEGKIWMYDADPFKTLLERQECKATAEKKRREVEAAKAKAKEMPGASGLALLSSAGAGPNAMKGWMTAPKVEMGRQTRIQLEALLRQGIISWNPHGVRMSREQRDGVVDDLSKIGFRRSHVAEAVEYCKDREETLEWLLIHVPEDDLPRWAFPENYAAGVSVGATNLKREGIIKSLSETGYAPELCTRVLDDSGGDEGKAAEALQAMLFPAPTPSGEDFLDMGGPDEQWEEEVASLEAMYGDNLRREDEQTIRVRLESVQDTGKTEIETHLRIRRPPTYPEHLILAIAGKLPSYIKLSIIRKALEYSAQSLRDEPLKMYLVTDWVQGHINGIIDDPGKLVDISAVASSTSDSRPKAAAAAAAAKGSADRSQPAARRAISWTADARSRDEWLKRQQQASWKDMESKRRRLPAWRMCDCIVRTVEENNVTIISGETGSGKSTQSVQFILDDLYEKGLGEQVNMIVTQPRRISALGLADRVAEERCSRVGDEVGYAIRGESRRSERTRITFVTTGVLLRRLQTSGGRMEDVAASLADVSHVVIDEVHERSLDTDFLLTLMREVLRGGGGPKLVLMSATLDAASFRHYFASEGLSVGLVEIAGRTFPVEEYYLDDVLRMSGLMDVEGMDHDDSRGASSEWGFNDLSLGNNNNNNNNKANDAAVERTMKRLAQRMDYDLLAETVRAIDLELSLEKETGGILVFLPGVAEINQACGRLRGTSSLQVFALHGSLETSEQKRVFGRPLAGKRKVVMATNVAETSITIDDVVAVVDSGKVKETSFDASNNMRRLEERWASRAACEQRRGRAGRVQEGRCYRLYTRQTERQQMAERPEPEIRRVPLEQLCLSVRAMGVRDVAGFLERCPTAPSGLAVDGALRLLGRMGALDGTELTALGRQLATIPADLRCGKLMVLGALLGCGDDCVAIAAILSTRSPFVTPPPEKREAAREARMRFAAGRGDGDLLTDLAAVEAWEEMTRVSSGGGGRQLRAFCEENFLSQQALRDILSTRAQLYSALEEEVCLGLPGRRRERERDRERERDRGPTAERDPQLLRGLVAAAFAPQVARIQYPDRKYASGMSGAVELDPEARAIKFFTQENGRVFVHPASTLFGCQTFTGDAAYVSYFGIMATSKVFIRDLTPLNAYGLLLFCGAIELDTLGRGLVVDGWIRLRGWARIGVLVARLRGLLDRLLARRVERPGEVVEGAEEVIRMRMKRMTQGAYTGRMALGAYLDDPGSHPSPSPIIYHTDAFVALRDRYPKATVHALLLPRDRALARRHPLEALADPVVRAVFARELPSMSHLHIHVLSRDLHSATLRHGKHYNSFATDFFVRLADLPLSEEQRALRGRLLRSDLVCWRCGRNFGNRFRALKEHLETEFHDWRRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2N3</accession>
    <name>A0A367L2N3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Concentrative nucleoside transporter C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_4627</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2N3"/>
    <dbReference type="STRING" id="1330021.A0A367L2N3"/>
    <dbReference type="OrthoDB" id="6075923at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008276">
        <property type="entry name" value="C_nuclsd_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011657">
        <property type="entry name" value="CNT_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002668">
        <property type="entry name" value="CNT_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590">
        <property type="entry name" value="SODIUM/NUCLEOSIDE COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 28 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07662">
        <property type="entry name" value="Nucleos_tra2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01773">
        <property type="entry name" value="Nucleos_tra2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="412"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="512"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="548"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Concentrative nucleoside transporter N-terminal" evidence="9">
        <location>
            <begin position="169"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoside transporter/FeoB GTPase Gate" evidence="11">
        <location>
            <begin position="250"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Concentrative nucleoside transporter C-terminal" evidence="10">
        <location>
            <begin position="354"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI08693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="583" mass="63972" checksum="C5A0515993B79454" modified="2018-11-07" version="1">MDEKSDNKHHLVHGHDVENKDAAQGSTDLTSAPGDDDAVHDRQQQPLLARLRRHRHRRIVVHLFFFLLFTGWWIASLVLHRHDKNWIVPFLLWLAITLRLFFYHVPIRYVSDPIRWLWCHSAVVVHDAIPSRFRTLVGAGAAVAVILVGSFVTEESADNTRANRAVSLFGMAVIIFSFYLTSAARRRINWRTVIVGMLSQYIIGLFVLRTSVGYDIFRFIADRAGDLLGFAKDGLAFLTTPEVARTPWFLLGVIPAIIFFISLVQVLYHVGFLQWFIRKFATFVFWAMGVSGAEAIVAAATPFIGQGESAMLVRPFVPHMTRAEIHQILTCGFATISGSVLVGYIGLGLNPEALVSSCIMSIPASLAISKLRYPETEETLTAGRVVLPEDDENKAETALHAFANGAWLGIKIGATIVASLLCILAAVGLINGLLSWWGRYLDINDPQLTLQTILSYVFYPVAFLLGVPRHGGDLLKVAKLIAEKVVTNEYNAFTKLAHDPEYSNLSARSQLIATYAVCGFGNIGSLGIQIGILGQLAPSRGGDVSRLAFSALISGVMSTLTSATVAGLVVTTQINDFTRTGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2R2</accession>
    <name>A0A367L2R2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stress-response A/B barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2R2"/>
    <dbReference type="OrthoDB" id="3830014at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="1">
        <location>
            <begin position="5"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="113" mass="12460" checksum="D459955B576C6F89" modified="2018-11-07" version="1">MAARIHRVTLFKIPKPDDQKTLIEQYKVLLATNAKDGKPYILSLTAGIAEQDQRSQGYTVVSKTEFASLDDMRYFDDECKAHQDVKAFVAKSLTVEGVMTVYFTPGVSGGASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2Y1</accession>
    <name>A0A367L2Y1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L249_4785</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2Y1"/>
    <dbReference type="STRING" id="1330021.A0A367L2Y1"/>
    <dbReference type="OrthoDB" id="4778251at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 15" id="KW-0732">Signal</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016917098" description="CFEM domain-containing protein" evidence="15">
        <location>
            <begin position="22"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="16">
        <location>
            <begin position="40"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="137"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="204"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF05730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCI08785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="274" mass="28959" checksum="227947F9ACD6EF4F" modified="2018-11-07" version="1">MGRLAPLVAIAALAFSQAAAAQNPDTPPCIVSQAALVVRADFAKLGCQNADDAACLCTKDNFSFGVRDCGAHCGSNDDNVRRFLLGSFCAAYARRHLIRHAELANRLHSAAVYSGHIYHTADLVYFGRRGIKPFQTSTSASVTSSPVTDSPPSSTSVDAEMSGSTGGSSQASVIGIGVGVGAAVVALAGVVICLLLRSRKQKPRQSMEISKPLPGSGRAYAGRERGSFEKHGNDIEMTSHRYEDMVPRQQPRTMALQRAGMHPGIFSFLFMAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L340</accession>
    <name>A0A367L340_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glycosyl hydrolase family 32 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_4918</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI08851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L340"/>
    <dbReference type="STRING" id="1330021.A0A367L340"/>
    <dbReference type="OrthoDB" id="202537at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18622">
        <property type="entry name" value="GH32_Inu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.115.10.20:FF:000002">
        <property type="entry name" value="Invertase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018053">
        <property type="entry name" value="Glyco_hydro_32_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013189">
        <property type="entry name" value="Glyco_hydro_32_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800">
        <property type="entry name" value="EXOINULINASE INUD (AFU_ORTHOLOGUE AFUA_5G00480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800:SF2">
        <property type="entry name" value="INVERTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08244">
        <property type="entry name" value="Glyco_hydro_32C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00609">
        <property type="entry name" value="GLYCOSYL_HYDROL_F32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016892825" description="Glycosyl hydrolase family 32 N-terminal domain-containing protein" evidence="5">
        <location>
            <begin position="20"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="6">
        <location>
            <begin position="33"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 32 C-terminal" evidence="7">
        <location>
            <begin position="399"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI08851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="514" mass="56455" checksum="B729E9D048A0E634" modified="2018-11-07" version="1">MTALQLLLLLLLPTTSVTASDPLYSGVYRPQVHFSPPRNFMNDPNGLFRSPKDGTWHLYYQYNPTGLVAGNQHWGHATSPDLYHWTNQPIALSPPNNQTFVWSGSCVVDVNNTSGFFPNQHDGVVAIYTLAGPDRQSQAISYSRDGGYSFTAYDGNPVIPGNSSQFRDPKVIRYQDHWLMTVAYPTDFAIGLFTSHNLVDWTPVSNFSLHGLLGLQWECPNLVRVPEVDHATGRRLDDTWLLVVSVNPGSPLGGSVTQYFPGSFNGTHFEAVDSAVRFADFAKDYYAGQFFYGVPDQEAVFISWASNWQYAEAVPTAAEGWRSAMSLPRRTALTRAPAVGWKLVSQPYDLSPVLAGQLLSQPNVANNALTLDFASVQSNALYWEANVTGLSGFPPAASLNVSFTSSRSGERLDAGYFIGSGAFFLDRSQLRAFQSPFFTDKFSVAAPRQSGSSWSITGVFDRSLVELFLDRGVDSATAVFFSDQPLTNMVIASSGLPDEARVSVRVNALRSVWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L348</accession>
    <name>A0A367L348_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI08860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L348"/>
    <dbReference type="OrthoDB" id="4927895at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="284"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="635"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="674" mass="74629" checksum="D04FF2B7B51AAE62" modified="2018-11-07" version="1">MSIELESLLLLHPRAWYYEHGSLVAMCSVALISISRVRRKLVVFFDDLRNFLFKQTSLFGGSPSPGYSSRRTTLDRGTAAPTGKQQQSNASSVSSKNIKAMQHLASMALVLTLYLAIWTSTSNAAPIPPIRGLTSGIAGGSSRESQSSKSKPGGSSSWIFSSSSIPSLDLSRRLKSQPKPELPARGTVNRLGPPVDRSRKPGPPVDRSRKPGPPVDRSRKPTGDPFSTVKTKPYMFLLPKPRPAASVKTPKKQEVAGFDKPVKQETGSLDRPSKLQGTSGELTQKQQQPVPQKQQYPPPLPAKQQAGVSVAGEQHVKESLKKQGAAPEEQQQNAEPPVTESREFKLANGDTYWTVKRVSQPLTDADVRPKDGGRHSKEVKDGSRHLKQITNVEAEEEEEEEEEGAEDFHSKIEELRKLLTDAESQLQGARPRRVLASEELNLADGGNQPSSPARRIRQPSPVDETADGRQPRILSSVDELEVANGKVYSSVSGGIRGRPLTVADRMFLSPRTRGREDVKATFREIDKAMSFVPVDLSNANPVATSRRTGRVSLASLKGLLAKKRGRKGENSPEAKKKLKMEDSMSEENAVTIPRRSRFARIKDALTRPFRKRRRNGAKTEKEKTQKKERKKERKTGKGEKNAEGKTGRDSSRSRTRLSTWLWDKKMGRRQKISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3R3</accession>
    <name>A0A367L3R3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_5108</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI09073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3R3"/>
    <dbReference type="STRING" id="1330021.A0A367L3R3"/>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd09630">
        <property type="entry name" value="CDH_like_cytochrome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1210">
        <property type="entry name" value="Cellobiose dehydrogenase, cytochrome domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015920">
        <property type="entry name" value="Cellobiose_DH-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF1">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16010">
        <property type="entry name" value="CDH-cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49344">
        <property type="entry name" value="CBD9-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016884475" description="Cytochrome b561 domain-containing protein" evidence="9">
        <location>
            <begin position="19"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="10">
        <location>
            <begin position="181"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="383"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="419"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="437"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI09073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="461" mass="50455" checksum="BFE97CD837D97AAF" modified="2018-11-07" version="1">MRFWHAALAAAAAAVAAARQSTFLSPSRDLAFALSVPETDNTDLYFSLRASVNHAWAAVGLGSDDMKGALFLVIYRNKNRDNVTLSPRLAYGNYEPEHYPDLQYEVLPGSGIFDDHMVLNARCIQHCRSWPAADSNSGYMDVSSPTEKAIYALGPRTGFGSDNPAADLQIHREFGVFTMDVKSTLGAADPPVLAADTAAEGTELDYRNTGTRDHRSGLHGTFMVISVVLLMPVGAALRRFGRWARFHIPCQLLAVAIMLGGVAAGVMASLRYQRSRYFRSTHQILGFVVVGFVLIQVAVGFFHRQKTMKTHAPSQYGKYHRFLGGIITVLGTLNAFFGFDFALDYKIGYILCALVILFVFVTLFLYLGRQGIREKYQRRAAASAGGNPLGSAPTGYQPQPWRDNEHDSSPTDAPPSYESHASQSIGLQPMSSPWRSSDVKDGGDDHHPALGGAQQQPREFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L438</accession>
    <name>A0A367L438_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_1464</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L438"/>
    <dbReference type="STRING" id="1330021.A0A367L438"/>
    <dbReference type="OrthoDB" id="6270329at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047134">
        <property type="entry name" value="RNF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23041:SF78">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23041">
        <property type="entry name" value="RING FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="202"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="84"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI09195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="283" mass="30903" checksum="996855618C91DC87" modified="2018-11-07" version="1">MATALPFAEQRFDPSSAAELSLVDLPSDPAEWQVAWPPGLPSLPSLHQDISATLPSAGLASHQPPSALRLGALDLSSNFTNRLAVGRPTSTRSQAIPDFRSRPLTGMPPPRPQVSVDDDPNRNPNRAPKRRRTASTLGPQQAAPSLAFPVPFDDDNPFVDDNVKADEDDLPTIDLTNVEAAVPEKSKEPENDQIVKMSTFQCSICLDDAKTVTVTHCGHLFCQECLHKSLHLNPSRGLCPVCRAKIDMKPRSAYTSKTKGYWPLELKFVTVDKKGKHKADSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L480</accession>
    <name>A0A367L480_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_1406</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L480"/>
    <dbReference type="STRING" id="1330021.A0A367L480"/>
    <dbReference type="OrthoDB" id="361494at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031464">
        <property type="term" value="C:Cul4A-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000109">
        <property type="term" value="C:nucleotide-excision repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042238">
        <property type="entry name" value="Rad28/ERCC8/Ckn1/ATCSA-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46202">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46202:SF1">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="101"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="158"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="244"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="310"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="466"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="473"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI09236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="510" mass="55028" checksum="7D6ABFEEBA701A76" modified="2018-11-07" version="1">MSQWEVKRFQCISHSANHPADIIAASLQNPPGQRPSSHQLLAHPFGSAYDQCMQARLLLARETGDFGAHDLARTITSDLIRSFAPAPHHRFVGEPPIGQRVVAHANGIGSIALDKFDGRILLSGGADGSIRLWDLEQGAHPLRPHDFRPLSSIVRGVAGGHTHGITHLAFFPFDPDAFLSSSYDKSIKLWSTQRCALTASFDLNATVYSHATSPIADHLLVACATQHSNVRLVDLKSGSALQALVAHGGPVLCTSWSPRKEHILASGHADGKIRLWDVRRAGGVIAQLDQDDTRGFDPAADRVPPFDASAHAHNEPVNGLQWTDDGRFIVSAGLDRRIRVWDASTGANTLASFGSLVQNQQVKTASFIITPSALSAHQDIIFWPNDHEILAYDLHRGNLVTRLRSPGSSNPVAARGVNASRNRITSIAWRGAGGGGRLIGPVMGGGNSFGAIYSSHHDGQVRAWMPSVPGPNDIDDADDELGEDDEVKSRKRKAVDDAYRSLMGKKVTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4T7</accession>
    <name>A0A367L4T7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_3754</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the paxB family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000015">
        <property type="protein sequence ID" value="RCI09427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4T7"/>
    <dbReference type="STRING" id="1330021.A0A367L4T7"/>
    <dbReference type="OrthoDB" id="5294024at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039020">
        <property type="entry name" value="PaxB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42038">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42038:SF2">
        <property type="entry name" value="TERPENE CYCLASE AUSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25129">
        <property type="entry name" value="Pyr4-TMTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="307"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="464"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI09427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="498" mass="54577" checksum="F06A311EAA03243C" modified="2018-11-07" version="1">MSHNQQPASEKTCLVTGGAGGLGKAIATAFLEAGANVIVCDINAERLSQTSTELAKLGSFTAVAADITSADAMQRLCRQIIGDFRTLDILVNNAAVMDRFDPVADLDMDLWHAVLAVNLTAPMLLSKLAVRLMLEKPDPSGCIINIASSAAKAGAAYTTSKHGIIGLTKSTAAFYGDKGIRCNALAMGVMLGTNIGDAFQAECHREGQQKVMDLVSGTKPRSCHVQDVASLCVSLSCGPGWNLVNGSVIAVDHGPRHQTMNVVDPSQAPPEYQRVAWMADTCKLLMGIGWTANYIGMIYTSLQHDTYAMSLMALCCNFAWEVTYALIYPFGSRLEKSVHYSGLVLNCGVMYTAVKNAPREWTHAPLVQRHVRLIFVLCLAGWTSAHMALAAQLGPLLAQAWSAYGCQLLLSVGGLCQLLCRGHSRGSSYLLWFSRFFGSLVLVPHDILRYRFWRKDHEYMASPLYLWFICIFLLLDGAYAVCLWHVRRFEREREVKRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L542</accession>
    <name>A0A367L542_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">VLRF1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_3922</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The VLRF1 domain mediates binding to the 60S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ANKZF1/VMS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L542"/>
    <dbReference type="STRING" id="1330021.A0A367L542"/>
    <dbReference type="OrthoDB" id="429841at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047139">
        <property type="entry name" value="ANKZ1/VMS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041175">
        <property type="entry name" value="VLRF1/Vms1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16036">
        <property type="entry name" value="ANKYRIN REPEAT AND ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16036:SF2">
        <property type="entry name" value="TRNA ENDONUCLEASE ANKZF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18826">
        <property type="entry name" value="bVLRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52044">
        <property type="entry name" value="VLRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="VLRF1" evidence="13">
        <location>
            <begin position="225"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="464"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="31"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="541"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="279"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="541"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="594"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="612"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI09539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="634" mass="71116" checksum="8303587D0490A3D6" modified="2018-11-07" version="1">MASSSQELLRRPLYVYHLPAQVLETLKVQASDVDYEREEDEKSHPYSPREEEEEEENKPADGPVGAQSCSLCVMAFAAVEEQKSHHKSDFHQYNLKQKLRGKKPVSETEFEKLVGHLDESLSGSDSESEDEEQESTLAALLKKQARLADPNADGDMDEAGTRRRTRPPLIWFSSDLLPGKTCFGLYRAILTSEEQRDSDVVQVLKGKQLAPVSVPNSPMPPLAYKGSHVFLCMIGGGHFAAMVVSLAPRLAKGPTTMDREATVLAHKTFHRYTTRRKQGGSQSANDNSKGNAHSAGSSLRRYNELALVQDVRALLADWKPLLDSSELLFVRATGTTNRKTLFGPYDGQVLRYNDVRLRGFPFSTRRATQKELMRSFIELTRLKVREIDPSKEVKVEKPASASASAPAVKVAKPKLSKEEELALLHSGQLQAFVRRSKLPALLTYLKANELSPDFEFQPREQHQRAPRPLHLAASQNSAPMVLGLLTRAGADPCIENNEGKTAFELAGDRSTRDAFRVGRSELGESRWRWEAARVPSAISRDEANRRDEREKVEAEKKESERRGAEEERLRVEGPRVSDAKRGGVSTLASARTKTPQELREEEMRGLTPEMGMRLERERRARAAEERLKKMRSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5I3</accession>
    <name>A0A367L5I3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5I3"/>
    <dbReference type="STRING" id="1330021.A0A367L5I3"/>
    <dbReference type="OrthoDB" id="5576763at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="222" mass="24094" checksum="F582065F3C033744" modified="2018-11-07" version="1">MLLLASLASPSLAALGDGFIAQSQWSFKTAPPEGLDDIAFPFNIRNAPRKKGFYFAQQFDFTNNADFAYCGLQPQEDENGKPMIRALFSSFQRGSDTNDPNCSYGADGGPGISCAVKISASYEPTYFIRISSAGDGGNRTWRGTLIEHGNGKETHIGEWTLPEAGKIRSNFIGLVEYFPWNLDPDECSRLPRTEVSFGHPTSETCGAQGGEITETASVTDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5R2</accession>
    <name>A0A367L5R2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4077</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5R2"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="144" mass="16056" checksum="4627E3FDEB13C3C6" modified="2018-11-07" version="1">MSKHIESHQRFPRRPLSPLRPVLPLHFASYCSFSQSGSCESRHTEPPSPSDYAHRRSPISNTLVVEKGENKTAAGFRCKSGTMLKRHVPPTNHVFGPPSDMGSYSHRPEKFCAAGPGAELVYRRALFFSSYLCILRAGEGRRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5T5</accession>
    <name>A0A367L5T5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sulfate adenylyltransferase</fullName>
            <ecNumber evidence="9">2.7.7.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP-sulfurylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Sulfate adenylate transferase</fullName>
            <shortName evidence="9">SAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MET3</name>
        <name evidence="14" type="ORF">L249_3913</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP. Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur-containing amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine 5'-phosphosulfate + ATP = 3'-phosphoadenylyl sulfate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24152"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.25"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>sulfate + ATP + H(+) = adenosine 5'-phosphosulfate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:18133"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58243"/>
            <dbReference type="EC" id="2.7.7.4"/>
        </reaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="9">Allosterically inhibited by 3'-phosphoadenosine 5'-phosphosulfate (PAPS).</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8 9">Homohexamer. Dimer of trimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="9">The adenylyl-sulfate kinase (APS kinase) is non-functional. It is involved in allosteric regulation by PAPS. PAPS binding induces a large rotational rearrangement of domains lowering the substrate affinity of the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the C-terminal section; belongs to the APS kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the sulfate adenylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.4" evidence="9"/>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367L5T5"/>
    <dbReference type="OrthoDB" id="468at2759"/>
    <dbReference type="UniPathway" id="UPA00097"/>
    <dbReference type="UniPathway" id="UPA00140">
        <property type="reaction ID" value="UER00204"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004781">
        <property type="term" value="F:sulfate adenylyltransferase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070814">
        <property type="term" value="P:hydrogen sulfide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010134">
        <property type="term" value="P:sulfate assimilation via adenylyl sulfate reduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00517">
        <property type="entry name" value="ATPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000802">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000052">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.10">
        <property type="entry name" value="Sulfate adenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03106">
        <property type="entry name" value="Sulf_adenylyltr_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059117">
        <property type="entry name" value="APS_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025980">
        <property type="entry name" value="ATP-Sase_PUA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027535">
        <property type="entry name" value="Sulf_adenylyltr_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050512">
        <property type="entry name" value="Sulf_AdTrans/APS_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024951">
        <property type="entry name" value="Sulfurylase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002650">
        <property type="entry name" value="Sulphate_adenylyltransferase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004040">
        <property type="entry name" value="PRK05537.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00339">
        <property type="entry name" value="sopT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42700">
        <property type="entry name" value="SULFATE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42700:SF1">
        <property type="entry name" value="SULFATE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01583">
        <property type="entry name" value="APS_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01747">
        <property type="entry name" value="ATP-sulfurylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14306">
        <property type="entry name" value="PUA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-sulfurylase PUA-like" evidence="13">
        <location>
            <begin position="4"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Sulphate adenylyltransferase catalytic" evidence="12">
        <location>
            <begin position="179"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="APS kinase" evidence="11">
        <location>
            <begin position="398"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Allosteric regulation domain; adenylyl-sulfate kinase-like" evidence="9">
        <location>
            <begin position="398"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="609"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1214"/>
            <end position="1253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1344"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="633"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="672"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="697"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="752"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="776"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="833"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="872"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="884"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1362"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1387"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="200"/>
            <end position="203"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="294"/>
            <end position="297"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="437"/>
            <end position="440"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="518"/>
        </location>
        <ligand>
            <name>3'-phosphoadenylyl sulfate</name>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <note>allosteric inhibitor</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="9">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="9">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="site" description="Induces change in substrate recognition on ATP binding" evidence="9">
        <location>
            <position position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00062002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF14306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI09781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1411" mass="156720" checksum="C46B7FDB6E6A3EE2" modified="2018-11-07" version="1">MANPPHGGVLKDLFARDLPRHDKLMDEAERLPALVLSERHLCDLELILNGGFSPLQGFMTERDYDGVVQHSRLADGSLFSMPITLDVDDKQLAQLDIKPGARITLRDCRDDRNLAILTVDDVYRPDKQVAMKEAKQVFGSDDDTHPGIKHLLSVAKEYYVGGQLEAVNRLEHYDFLDLLTPAELRSHFNKLGWQRVVAFQTRNPMHRAHRELTVRAARSQHANVLIHPVVGMTKPGDIDHFTRVRVYKALLPRYPNGMAALALLPLAMRMGGPREALWHAIIRKNHGATHLIVGRDHAGPGKNRQGRDHYGPYDAQELVKQHQDELGIRMVEFQEMIYMPDRDEYQPANEIPEGARTMNISGTELRNRLRTGKDIPAWFSYPEVVQVLREQNPLPREKGFTVFMTGYQNSGKDQVARALQATLNQSGGRPVSMLLGETVRHELSSELGFSRQDRDLNISRIAFVASELTKAGAAVIAAPIAPFDEARRQARELIERSGPFFLIHVATPLEYCERTDRRGIYRAARAGEIKGFTGVDDPYERPQQADLVVDLAKQNVRSIVHEIVLLLESRGLLDRLHFRLLLLRLLLLLLLVVEFSPMARIRILSPPRLKHDDVSRDRHHRSRSERKSDKDREHRHHRSSKSSRSKTVADDGDDSPSRLSSRRHRKKDQTDLSDLTASMTLNKQRISMPYPTFSKAHSKEAVHSRDNLSPKRPSNPPTPEPTDAGDGRRSRSASKKSSRPPTPPTPPETDLSADKRRAAPKADDESNPDRPKVMRKSSSSSQATYIRSPPAHKSHERLRSSGSTRSSSSHRSRKPSSASIRAKTHDPTDDDSPPSSARQSSSLRTPMAPSPSPPQQIVGNKAPPADHDDEPAWSSSKTTTPAPSSAPPPPPPPPAVDVQMAPRVDYLLQNGGLPCPVPRRFMSVLPSSNGGVVRSLSNPSQAGAESLFAPFFNLLDQYSSVLSKQGSIAVATGHRSVARRLLDRLENVFSRDLPPHGCVCVMCDGCQDVHSGLNWGDVLESVSGRIQLPAWPPFDLAELGEKAAEMSAEAPPRPASPVKMDPDIAEEFRDHYLRQSKKVRSAVDRWLKQTGADVVPPPQDVDDETLAFAILTNMAPDDRPYFNALMTGSRDLKPSTPVTGYRPRNDFLVKCGLALQRLYRLSQMPRDAESATYLVKNPQTHDLLVAMANIHASEWEILISGRFDGFLWSGADADEAGTESRSGTPCGNRPSMSPGPRGTSTTGSRHATPFSPYSRVTTPASFVSLASSGQAAGGRPPVSNDEEMEIAAAAEMEREIFAGMETLEDAFEKLHHKAEMVRDALRQRGAGLMQNVQNRRRIDVLPTHSAGGHERSAWAGGSEGEGVSDDDWAIDDVEIMPDDSASNMSSSRHRRPKRRTERRTPAPIEEDEEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5Z0</accession>
    <name>A0A367L5Z0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_3810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5Z0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI09843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="66" mass="7691" checksum="BBEFBEF9F4C220CA" modified="2018-11-07" version="1">MIDLSARGRAQKRKSEALIVLSAQFSSSNNTNLVHRVPRQRHKLLFRRVDTSKPLKEEKKILRHSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L627</accession>
    <name>A0A367L627_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chitinase</fullName>
            <ecNumber evidence="4">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L249_3848</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="4"/>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L627"/>
    <dbReference type="STRING" id="1330021.A0A367L627"/>
    <dbReference type="OrthoDB" id="76388at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
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        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
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        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF317">
        <property type="entry name" value="CHITINASE 12-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
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    <keyword evidence="7" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017033302" description="chitinase" evidence="13">
        <location>
            <begin position="20"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="14">
        <location>
            <begin position="38"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="413"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="688"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="783"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="415"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="453"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="479"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="717"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="783"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="812"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="825"/>
            <end position="835"/>
        </location>
    </feature>
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        <location>
            <begin position="840"/>
            <end position="851"/>
        </location>
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        <location>
            <begin position="872"/>
            <end position="893"/>
        </location>
    </feature>
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        <location>
            <begin position="917"/>
            <end position="931"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCI09672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="997" mass="102763" checksum="312ADCA9F8952CFA" modified="2018-11-07" version="1">MSLLRTSLAVLAAAQAVVGLVPSTHHQLAPHAQGGDSYVNIIYWSTGNMMRISDAVANNITHVMYAFADVGSDGTVTSSFNSEAVGSGTFNSQRKGEENLGGRWAQLFEFKKANPHIKTVLSIGGWLEKDSPKQKALESGASTDKNRKRFADTAAQLMLDGGFDGLDVDWEFPETAQQADDHALLMKAIRHKLDQLAESHDNHHFLLTAAISASPWRQGSLRLSTLATLLDYIYVMAYDYTGNYGHNVRHAANLYMSTSNPNSTEISTDQSIRNLVSNGVPASKIVLGIPSYSHAFRDATLGGPRKGSSHVGAYPLRQLNSELRVECDLQVVACSAKDDKTKQLFLFDTAQTVAIKAKYAQDNKLAGTFFWDLNQDYLGDKALYVAAANQLGNLDRSTVGLLEFAGSRYANVRGSKSLSSSPAASTSSSSSSSSSSSSSSSSPSASAPSTPAVSPPPALPSPPFPLNSSSTDRHHHHQQQQQLTDATSSTTALSTATALGSQATDAATDDSPAPSSPDSAPSGGIICAAGESCASKNNDDDDDKKMVPAIYANGLVVKNVVAVVVVVVVDAGACASKNNDDDDDKKMVPAIYANGLVVKNVVAVVVVVVVDAGACVAGEACRGDKKNATMTTATEFAFATLCPMEVEVTPITTATVSSRAAASEPIPVTMDGRVAHVCMAEFGCRASEMPPPPPPPHSHSSPAANRAAAGGFGPGSAPGSASGSSSSGLDVAPGRAEAEARLMFGNGSGSAAASSGSDLAVSAAGSNSGVSSDSASVVASNSKVVVDSPSSSASHSVADEKNKKEKKKKCKDVKASHAVKADKTTGPSHAGSKQQKAGYDAVNNDDAAAAAEPVSSNQVTKGAKPSHDAPSQAVSDDGSPTSNKEAVSSNQVTKGAKPSYDAPSHAVSDDDSPTSNKEADVDVTRVSEKPGRGPQAGSKGGVQPFATGMMTSPSSSPFASSNVTRPAGMAMTGDAGRKISSWAATLLSAVAAMVVFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L648</accession>
    <name>A0A367L648_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_3863</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1330021.A0A367L648"/>
    <dbReference type="OrthoDB" id="3946750at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="725"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="239"/>
        </location>
    </feature>
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            <begin position="257"/>
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        </location>
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        <location>
            <begin position="468"/>
            <end position="559"/>
        </location>
    </feature>
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        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
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        </location>
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        <location>
            <begin position="307"/>
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        </location>
    </feature>
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        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
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        <location>
            <begin position="344"/>
            <end position="356"/>
        </location>
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        <location>
            <begin position="468"/>
            <end position="478"/>
        </location>
    </feature>
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        <location>
            <begin position="499"/>
            <end position="515"/>
        </location>
    </feature>
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            <begin position="532"/>
            <end position="545"/>
        </location>
    </feature>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI09878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="759" mass="84047" checksum="82CE7D952F9C5A2F" modified="2018-11-07" version="1">MLAIPSSRSKLGTMAHRCLRQSNLAVSTVASRQYRTLHSRWSCRRANKYWYTESFSRGPLSWDRDDIARDAIRARFFATNVDRECDHRPRRKSFKEDKLAALCGILHSCRAISQSAAYSSSAQKPPQDDDSFIDPITNRRVSKVFSVAGTRSGDKPQVKPQYEKGTATEQPSGGYEDLDEYKDPILWKEPDGLPDPSPEDLSKNYDDLDEYGPVRWHEPDGMPEPSAEDKSKNYKDLRKYKDPYVVPDSLLSAYEKKQQTVTQKAEPLPGKVPVSSGEPAKDNKDLGDYGPTYWREPDGLMEPSAEDLSKNYQDLEKYDAQYDATESTSQPSAGISGDAEQCDNKSCATTRPSQASKKCRSLPKHVTDGLGVSGDVENKPSNSKYQDAYNEPGAEPLIWTGLDKGAGPCQPKKADDMMRRACERRFQRADLKKGVDVEASSMEAKSKDGLTGKYMWDFPEDFSTSWSTANSWSKSTLYPDNGDQVSAAVADLGRDEAEPSSMDESFPSESSSEVPQLQPSLDRGRDRRKVMSRLERKRLEKDPYSKEPQGLETSYSEECGGRLGRPRVRFHEVKAATAAADGAKRMASYKILAYDEDRNSVDVTETTWPATQMTASFSPAEVLPRLTSPNKFLPHFATLQAEGYEMVSGGGDVLVFQRIIQETWSATQGAAAINPIDMTGGPVTGNFASPTGFVNYETTQAAEAKASTVGQPEGAGRRRRRGNKLWYVVGGALGWHLGGVVLERSEQRRKMSLGGGGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L655</accession>
    <name>A0A367L655_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_8765</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI09904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L655"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI09904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="92" mass="10206" checksum="3BB23D6991FD6E63" modified="2018-11-07" version="1">MHAYQGCLGGSGPLSGPLTSVTLPAPFSMFLPGQGPENPLSLGPSLFERHRIGVQSCPKGIVYDDYRNWLSRCDVESRRERQGAETRFEECY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L684</accession>
    <name>A0A367L684_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_8616</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI09929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L684"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI09929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="701" mass="75337" checksum="60F3A4FB072DA230" modified="2018-11-07" version="1" fragment="single">MAFAFKAKGVREGFGFLGFSRSERKGMRAGQDLLPFLSCLLAMNLTVDLCSDLLLPLAFRDSPNGMRAGSDLTPFSCRPSNLPNQHGYRRDGDGLGAGTGFDPVSSGNSLHSSLLRLPFPSFRCNCQSNTVIAADSDELGAGIGFGPFSFCVFPLMTAADHFRSFNPSILSRHEQALATCDAVIAADSDGLGAGIGFAPFSSCVFPLMTAADHFRSFNPSILFKTPSNCDLRHGYRCGQRWAWGGLRIWPLFLFCHNRSRFSFLRKNLHLAIRLSLRTAMGMGRARICPFPPSASFLMMTADLFSRTSRRRLSTLKTFPPHASIISSFLSLNKFPILEVATSRQLGYRCGQRWAWGGHRICPPDKSILQLLAQDLSRDSGSSCNLKATCTVIAAASDGHGAGIGFDPCLLCLLLRTLTDLGYRTHPPSNFSSQDFFGPPFEESSCILESNSNGLLTDLGHRASFLDLNHIDSSNLSSQDLFLQFRQSNYTVIAAVSDGLGAGTGFDPISFVHARLDLMLCMSGLEGGFSILLFSCNLESNTVIAAVSDGHGAGTGFEPHCNLESNTVIAAVSDGHGAGTGFEPQSLLSSPASSVGLLMLCMSGLEGGFSILSFRTVSCNLESNNGYRCGKRLDLMLCMSGLVGGFPTFSRVYIFDFDLDSRETILYSSSSSSLLVAISSNAVIADGSDGHGAGQDLTPFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6L4</accession>
    <name>A0A367L6L4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">SSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L249_8549</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6L4"/>
    <dbReference type="STRING" id="1330021.A0A367L6L4"/>
    <dbReference type="OrthoDB" id="6510177at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015918">
        <property type="term" value="P:sterol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000008">
        <property type="entry name" value="NPC intracellular cholesterol transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1640.10:FF:000029">
        <property type="entry name" value="Putative Patched sphingolipid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053956">
        <property type="entry name" value="NPC1_MLD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032190">
        <property type="entry name" value="NPC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45727:SF2">
        <property type="entry name" value="NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22314">
        <property type="entry name" value="NPC1_MLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16414">
        <property type="entry name" value="NPC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016952488" description="SSD domain-containing protein" evidence="13">
        <location>
            <begin position="21"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="349"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="591"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="625"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="655"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="707"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="732"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="822"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1062"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1095"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1167"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1208"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="14">
        <location>
            <begin position="586"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCI10067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1269" mass="139240" checksum="1154A5DECF195767" modified="2018-11-07" version="1">MRHQLAPLVVAAAPVLLAESLTPKHEPGRCAFRGQCGKQSLFGKELPCVDNGRASEPDAELRKELVDLCGAEWSHSPVCCSLDQVKALKSELGTPNTLIGSCPACKYNFFNLFCKFTCSPDQSLFVNVTASVAKNGKRLVTEADQLISDQYGAGFYDSCKEVKFGGANSRAMDLIGGGAKDYHQLLKFLGDKKPFVGSPFQINFPTSYSQPGMDPLKDMHPKKCNDTDPDYRCVCVDCPEVCPSLPAVKEQGSCKVGALPCLSFASIFIYCILLAALVASVFGHVAWKRYAQHQVERTRLLHGSSHSDDEDEGGPVLTDAARDRPTRRYWLNDMCDKALGKLGHTSARFPGLTIGTSLLVVAILSAGWFRFDLEKEPARLWVSPSSAAAQEKEYFDNHFGPFYRAEKIFLVNDTQPSGPGPVLSYETLKWWSEVEQSIERIVSPAFGDTLQDVCYKPVNDACVVQSVTSYWWSRGGLSPTSWKDQLRNCARSPVDCRPKFGQPIEPSMILGGYSDDVADARALTVTWVVNNAQEGTAFLARAIDWENALRDRLLAVQGEAEARGLRMSFSTEISLEQELNKSTNTDAKIVVISYIVMFIYACMALGTPFKHIFRNPALLLVESKVTLGLVGIIIVLMSITASIGFFSWVGLKATLIIVEVIPFIVLAVGVDNIFLIVHELERVNISCPDQMVEERVARALGRMGPSILFSALTETVAFALGAAVGMPAVRNFAAYAAGAVLVNAILQMTMFVSFLALNQMRVEDHRCELWPWWQVTKARVHMDGSNGFASGSRGTHDDEEGPLQVFIKNTYAPHLLRRHVKLTVVAVFFGVFAAALALLPLMQLGLDQRVAIPDGSYLIPYFDDMYDYLETGPPVYFVTRGVDASRRREQQGLCSRFTTCQQLSLTNTLELERQRPDVSFISSPTASWIDDFLLWLNPVYEQCCVEQGSACFADRDPPWNTSLSGMPEGSEFFRYLQKFLSSSADDDCPLGGQAAYGEAVVVNGDNSAVQASHFRTAHTPLRSQGDFINAYSAARRITAEIREKTGADVFPYSVFYIFFDQYLSIVSLTAGLLCAAVGIIFVIACLLLGSVLTSAVVAATVVMSVVDIMGAMAIFNVSLNAVSLVNLIICVGISVEFCAHVARAFTFPSRTVMEGNNNAFRGRDARAWTALVNVGGSVFSGITVTKLLGVCVLAFTRSKIFEIYYFRVWLALVVFAALHALVFLPVALSFVGGGGYVDPESEGTAAQDLTDRRWRAIRDHDNSDSEDGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6Z0</accession>
    <name>A0A367L6Z0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Golgi apparatus membrane protein TVP18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_8479</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6Z0"/>
    <dbReference type="STRING" id="1330021.A0A367L6Z0"/>
    <dbReference type="OrthoDB" id="5591789at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019365">
        <property type="entry name" value="TVP18/Ca-channel_flower"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13314">
        <property type="entry name" value="CALCIUM CHANNEL FLOWER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13314:SF2">
        <property type="entry name" value="CALCIUM CHANNEL FLOWER HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10233">
        <property type="entry name" value="Cg6151-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01077">
        <property type="entry name" value="Cg6151-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI10197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="193" mass="21108" checksum="2B544FB73D108825" modified="2018-11-07" version="1" fragment="single">LPLCTSPAGRACVCDSLDSSRRPATINVHHLSPKLVHPNYPLPKMSLKEEFQTRNFSIYGQWLGILSMIICLATGISTIFTFSITLIIFCAFAIASSFLILFIEVPLLLRICPTSGKFDEFVRKISTNYMRAAAYLIMSVIQFVSIAFGRSALIAAAVFLLLTFICYLLAGIKGQDFVGSKTLGGQGVAQMIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L729</accession>
    <name>A0A367L729_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein Zds1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_8532</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L729"/>
    <dbReference type="STRING" id="1330021.A0A367L729"/>
    <dbReference type="OrthoDB" id="5589766at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040206">
        <property type="entry name" value="Zds1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013941">
        <property type="entry name" value="ZDS1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28089">
        <property type="entry name" value="PROTEIN ZDS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28089:SF1">
        <property type="entry name" value="PROTEIN ZDS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08632">
        <property type="entry name" value="Zds_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01327">
        <property type="entry name" value="Zds_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein Zds1 C-terminal" evidence="2">
        <location>
            <begin position="739"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="683"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="797"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="864"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="375"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="590"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="683"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="713"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="806"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="864"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="887"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI10236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="910" mass="100494" checksum="5B3C7F608A7C0776" modified="2018-11-07" version="1" fragment="single">SEQTSSRPRDEIAGSFGSRRGHTSQLSISDPSHHVTEAIGTLYGDEDDSGSEGGRPLSFVGGSPHNEQLQRTSLPDSHSRPSSHHQSASESSTSHSIPDQPTGSSSSRNEHVSLKKIQTFVAPSSSTSSSQRSNNSGDHNSKSPVSPTPSLRDVQADSTGSQFPLTNIDNPSDIAQELSNLQALRRLSMDVGNNIDPDMPPMGFSAMPPVAPSGDDDENDPSRLLWVPARVHPELAPTEFKSFLEKRVQSIRRRSGDSLLAADFDASLGRSDSLLKRNKSMLSRQIDNTGGRGAVGYVDGAERLERKRSSSGSQHGPELSLDELVKDPTKAVQRLAKESQGATAGTEGSTDDMPILPMAPGVGLRRSTRTTYRKGGSLRSGDRGSLSRRLGHRQSDGQYSDVSGTLSSEGVHGPIAAAAPSEPSVDTSRPARPSRRHRNLSQESSPTLAGADGSAEETIEPRPPSRAQQDWPPARTPPSSGRVTSSPPERTERLDSQAGRSFPQRSSSQSAKPSREQQTEAPEESSARPSRRPTIGSNMKQPAQAQYTTKSLNSMHLQTMNDSLASPSSLTGADASRTDSLTFIPTLSQPEKKVEKKSSKKDRDDDSSSTSSRSGSAWKWFKGVTDERDRKKEEGRKWKARASAEKTQDNVRLDVIQTSIDRSNAKGRESLVLDRENVDSKLLEERKKEGNRKSDSKKEKDGSIFSSIFGGSKKKEEKEKVQKKSQHLQVPEDVFYKPLTPDVDYNWTRFPLLEERAIYRMAHIKLANPRRSLLSQVLLSNFMYSYLAIVQTMHPQMNVPTSPQQKRLEEEARRKRREEDYLARQGEHGGENSLDQYNFDYHRAAVQYADSGVEGPAEYVDDAQIYEDDHADDCDDDEYGYEGVDSCGRDAKDYHHNEDDHHRHRRDDMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L787</accession>
    <name>A0A367L787_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_8468</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L787"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI10293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="185" mass="20875" checksum="7B86650545BC7BB2" modified="2018-11-07" version="1" fragment="single">MVHQGRIEVEDRPMEMAAGAQMQYGLCYGLVKETLTNQVQSGPFHYFRSPSDMERKKKAISEQNYEWLDGWMGLSRVATLGSLALASPEWVGQAAGERHRNFKMIIVRGSQDHQGNEETGPCISAKGLWIRIGRAVWAREKGVEATPMHTDIFWPKRQVRQEKGCDVGGLCCRDLTFFNRGDLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8D2</accession>
    <name>A0A367L8D2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8D2"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="47" mass="5394" checksum="E4F209318EA4C7EF" modified="2018-11-07" version="1" fragment="single">MVSNHGRASIRRTPAHGERRNWRCERKADSQKVQPSGAPVGDVPRWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8W9</accession>
    <name>A0A367L8W9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5443</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8W9"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI10873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="32" mass="3561" checksum="9398C8DB2C50BF28" modified="2018-11-07" version="1">MSASYKPSIASAISEGNSFRIIEQGPESYFRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8X1</accession>
    <name>A0A367L8X1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8X1"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI10867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="115" mass="13054" checksum="C5AD927F97ABFF41" modified="2018-11-07" version="1">MGLPPNHRSSKYVRVLQVGTLKYLEKIISISFSHLLNTNTSPASNSSSIASFRLSPRVQLSDSGYLYTFNLFFTTFLFTFRPTNYLIRTLFSDAFQQSDPLFLKKFPLSATIGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8Y5</accession>
    <name>A0A367L8Y5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SUN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_5409</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8Y5"/>
    <dbReference type="STRING" id="1330021.A0A367L8Y5"/>
    <dbReference type="OrthoDB" id="266334at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045120">
        <property type="entry name" value="Suco/Slp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953">
        <property type="entry name" value="MEMBRANE PROTEIN CH1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953:SF0">
        <property type="entry name" value="SUN DOMAIN-CONTAINING OSSIFICATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="SUN" evidence="7">
        <location>
            <begin position="242"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="409"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="476"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="529"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="409"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="431"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="552"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="575"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="594"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI10876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="841" mass="92485" checksum="92E45038F29E1C24" modified="2018-11-07" version="1">MSLTTVVPDYSRIKKYRADRALMMHIFILRLSPALPILSASLYPWVLAYGDDLGNPASREGVANPSTPSIALTTPSSISSPSLCEARTVNYITHMLPQLCLTNSWDGSGFTTYHSFRSGSTYQSTLAAESFRTSLLSDSSMSSLDGQPAEPTSFSFVSFEDWKEMMLRQVGQDPQTWRSRKVNQQVDYRFAPDDAHGAGLGEEGEISLDFVDYRNIDGKETKTESLHDEREGEAIEEAILPYGETVTHRSKDAGKTCKERFSYASFDAGATVLKSATGAKNARAILVENKDTYMLLECAVRSKYVIVELSDDILVDTVVIANFEFFSSMIRHFRVSVSDRYPVNVNKWRELGVFEARNSRDIQPFLVENPQIWAKYIRLEFLSHYGNEYYCPVSLLRVHGSRMLDSWKDSETGRDEDLQVHGQESVKKMTNVDNTPPTSKPVNFAGKIPTPSITTPWTGPWGAGLFHVLASATCPASSGQTSRNSSDHRASIDRDNAVESRRSEASAPEQPPEVSSPTLLARTSLHEASTALPTITPTDLSIASHSDDDEAAASSLTESANASATAAKDTATEGSDVTVSSATKSPAPGVTNGKPRTSGASGANGATTTVQEGFFNAIAKRLQQVESNLTLSLKYVEEQSRHVQEALQRGEQKQRSKVTLFLNDLNQTVLSELRNIREQYDQIWQSTVLALDSQADRSERDIMALSTRLNLLAEEVVFQKRMAILQAVILLSCLFLVIFSRGVPVPPLVSLPVTTDPPIPSHLFMYLHCITKISTIIPGPPLTHLLVVTLAVSTILNHYYLQGAPHKLSILANRFLLSPSTLDCVTTHEPDPGGTFPSDTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L981</accession>
    <name>A0A367L981_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_5295</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L981"/>
    <dbReference type="STRING" id="1330021.A0A367L981"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="803"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="832"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="358"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI10964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="856" mass="93463" checksum="7F223B74BE0ED35E" modified="2018-11-07" version="1">MADYKTHQLGDLPLESGQVLPGAFIAYKTYGDASLPCIIYPTWFSGWISDNEWLIRQDGALSPLRYFIVVPALFGNGQSSSPSNTAGPFPRITVRDNVTAQHRLLTDVLSVTHARCVLGWSMGAAQTYQWITQFPDFCDLAVPFCGSARTALHNQVFLEGVKAALLAARGKSSAGSCCGESGHDGAPRPWSELEATVGLKAVARVYAGWGFSQAFYRERLYEKELGYRSLEHFMRDFWEAWALSKHPENLMVMLHTWQASDCSAQEPYNGDFALAMRSIKTKTLVLPGQTDLYFPVADSEEEVRQMRRGVVLTLLSVDAFNRDDETLIKCLAQQSVPFTAKHDDKTWARATSSYNLRLNYTPSAVAMVRSAAHVSAAVRCGLASGSRVTAKAGGHSFGGYGLGGEDGHLVISLQEMNKLTPHATGTTVRVQPGARLRDVASGLYAWRKRAISHGSCLGVGIGGHVLHGGFGLASRTYGLALDWLVGAVVVLADGSVVRCSSSLRPDLFWAIRGAGSSFAIVVELEFDTFPAPETVTPFTLRLDDDALDGSALDAMQAFALQAPPEINFIIDFAPGGKTLSGVFYGGRREHLVAALGPLLRRVKGRLEVDDSVGWMEALMKFDDVPVDAASEHDTFYATSIMTKPLPTSNLNSLLSTLSKHQQDRRASPKRQLYLSIEAHGGPNSAVSRNVSSWDESSYAHRDKLLLWQIFDATDDKDGRYPPSGFDDLRRIRESLVPPSLLSDDDDDDDDDLDWGMFANYLDDQLDAVEAARRYWGGGHGLLRLREIKARYDPDDVFWNPQGVVVVVVVDVVVVVVVVIVVVVVVVVVVVVVVVVIVIVIVIVIVIVTVIVIVVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9Z2</accession>
    <name>A0A367L9Z2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_7244</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9Z2"/>
    <dbReference type="STRING" id="1330021.A0A367L9Z2"/>
    <dbReference type="OrthoDB" id="1078367at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042645">
        <property type="term" value="C:mitochondrial nucleoid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04496">
        <property type="entry name" value="SSB_OBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000424">
        <property type="entry name" value="Primosome_PriB/ssb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011344">
        <property type="entry name" value="ssDNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302">
        <property type="entry name" value="SINGLE-STRANDED DNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10302:SF0">
        <property type="entry name" value="SINGLE-STRANDED DNA-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00436">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50935">
        <property type="entry name" value="SSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI11235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="142" mass="15386" checksum="3C4E7048A34333E9" modified="2018-11-07" version="1">MASLMTLRRFALPSTTRSFSTSAARELARITIVGSIASDPVSDSTKSGRSLVKYTVASSTGQGEKKITSLFRVSCFGEGPRRDHLLNLTKGSLVYIEGDATLSQYLDNDGRRQTSLGIVQRTLSVLNAPQRSKRQDGEGDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAC4</accession>
    <name>A0A367LAC4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ste24 endopeptidase</fullName>
            <ecNumber evidence="3">3.4.24.84</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Prenyl protein-specific endoprotease 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">L249_7662</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic side chains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.24.84"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="17">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the peptidase M48A family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the taxilin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.84" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAC4"/>
    <dbReference type="STRING" id="1330021.A0A367LAC4"/>
    <dbReference type="OrthoDB" id="360839at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07343">
        <property type="entry name" value="M48A_Zmpste24p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.10:FF:000002">
        <property type="entry name" value="CAAX prenyl protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027057">
        <property type="entry name" value="CAXX_Prtase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032456">
        <property type="entry name" value="Peptidase_M48_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026183">
        <property type="entry name" value="Taxilin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10120">
        <property type="entry name" value="CAAX PRENYL PROTEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16491">
        <property type="entry name" value="Peptidase_M48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09728">
        <property type="entry name" value="Taxilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9 17" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="802"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="827"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="950"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 1 N-terminal" evidence="21">
        <location>
            <begin position="672"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="20">
        <location>
            <begin position="859"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="429"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="429"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="454"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="18">
        <location>
            <begin position="492"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="505"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="523"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="930"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="16">
        <location>
            <position position="1012"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="929"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="933"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="1008"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="22">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00060927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00083451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF16491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="RCI11366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1088" mass="124449" checksum="35502235DD39CA6B" modified="2018-11-07" version="1" fragment="single">SIKAASSLTTAPRVDARRDAAIPFRYVLQRVGRLKSSRARTPHASRFKARWTPSLIAVIILFTVMPASQIETELANGHEAHAHHTHPPPAAGRKAKGKMAMDSSEASRLLQARISQLEQDAAGEKDQEIEIEREVKRANRDLLQQVSKMDVMQRIDHLTKRSTELLADMRRLERDNQKNKKRGDILQKERDANRTELSKTVGLKEKLEKLCRELQRDNNRMKNENKDLQTTQKRNGMAWDEKYASLLAKLEGYQEEKDTPRKQVVDMEVDELFRVRFKSLIEQYELRELHFHSLMRTKELEVQYHLSRYEREKKNAETESNKARHLQLQVQAFTKTETELRNQLNVYVDKFKQVEDTLNNSNDLFLSFRKEMEDMSKKGKRLEKENDALKRQKDTTAANIIRMAEERQDWKRKLEAAEKKTEKLMSIIQQMQQQGRKLPPGTSSTVEGCYAGAEGDESDYSDEEDEEALSEFDDDTEEETQPSSRPVTYGPERPPPPPPPPPPQQQQQQQHQQQHQQQHQQQKQASQPAEATETQVGDDGSTVVTHHKVEGSDKEAKIQALHELLQRRDSGESVDAGEVTRLVWDLMPRPRVADVAEQRAGVLPHRRLDVFQPPASFYFAPSPRSIASIPASMDFLQRLSRFLDRPLFPWKKLILGFSIGQYVFESILTLRQYQVLLQKKPPAVLAKEVSQETFDKSQAYGRAKARFELINGLWAQVQNVAFVQMDILPALWDWCGGLVASYAPAVLSGEIGHSIVFVYVFILLQQVLGLPGRIYHTFVLEEAYGFNKQTPKLFVVDMIKTNVLTAVIMPPILAAFLAIIRRTGNQFVFYLWAFSAALQLFTTTAYPIFIQPLFNKLSPLDEGELKKKVEDLAASQKFPLNDLFVIDGSKRSAHSNAYFYGLPWKKHIVIYDTLIEKTETSEIVAILAHELGHWKLGHTTRLFAIAQVHLLYIFSLFSVFVNNASLYSAFGFHRSHPIVIGFILFSDALSPMDCILKLLLNILSRKFEFEADDFAKQLGHRAQLASSLIKLHAQNLSTMDADPVYATYHFSHPHLSERLKALDWKPSVALTSEKDKDKAVKASGREEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAC5</accession>
    <name>A0A367LAC5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_7669</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAC5"/>
    <dbReference type="STRING" id="1330021.A0A367LAC5"/>
    <dbReference type="OrthoDB" id="2351920at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008401">
        <property type="entry name" value="Apc13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28526">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28526:SF1">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05839">
        <property type="entry name" value="Apc13p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI11371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="103" mass="11296" checksum="ECBF680595202321" modified="2018-11-07" version="1">MNKDSSFTYVHMHRSADADLFDDFCKDSLPPDEVFVPPAHRPINPEDEDDVVPDQHAAFGIQRATQRVSEPAWKDLGLAELMRRGPAAAPAASGKPSASRAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAF5</accession>
    <name>A0A367LAF5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAF5"/>
    <dbReference type="OrthoDB" id="10661090at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="626" mass="65800" checksum="CD7042873754DF40" modified="2018-11-07" version="1">MELTGLRTTVACLAPNAKLGKDFYLYHPPSLVIVLDRSFASFVSKQLELFFHLPSFVCSSCKHSLTMFCRLYHRSVGAILFLQSVWCEHTGDAARPSQQAIAGVATSQVPSNGSAASKFHDVLFIEPAESASFQPTVIVRNSRSSQISTVKHAPPPTTTDQGTRSVQSTGLAKSDTLFILDDGSGVRPAPTTTTTTTDRGTRSVQSTGLAVSHTLYNTVFFDLVNGIPSGLDSSDGSSDRRTTKHAPSETAAAKGFKPVTKCNSGDPDCFNVQIQETVWISDGAMLSVFVTPSPIVQTRASLDLVREPVASLAVSVKQPAGAAFICPFNRPNCYLETSSTTVGHDAAASLQIEVGPPVASERKMVASDSNHHPVKERPSTIGTRHRENSAASYPPAILRPTATDNKAKPPFSSPVSTMVGEVMMPNDRDSSSAGQFRGSLPLSEEGAQSPDGPGGTSPTSGERRGRASQTVSNQRQASHSALDLSEQRPWQASQTVSNGQEASHTSEERQTVSNAYAQASPSPSSLDAANKQQASFTSLILSSANAKQAVNDPSSSPASADQRSASLTPSARMRQTSSPTPDSTEALQTTTTTTTASDPGQTGGVGGRSRGHAGLVVAVAGLLALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAJ2</accession>
    <name>A0A367LAJ2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_7331</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAJ2"/>
    <dbReference type="STRING" id="1330021.A0A367LAJ2"/>
    <dbReference type="OrthoDB" id="762982at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF49">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="356"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="55"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="104"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="686"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="114"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI11439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="825" mass="91704" checksum="6FE8EA5F9B4A1084" modified="2018-11-07" version="1">MPPTSPSYSLTMTPISPTMDPGSRSPEEQFRVVRRRNRVPLSCYPCRTRNNCIKREGMNPTSCSYATPSSRKKSTTSQAESSPDDIQNRIDRLENLVLSLMHNAPSPDHATARTGASASLSVTDSGSSSRAGHEGAAMVDDDSDVDDGLATSLGVLKVDVDKGKSMYVGQEHWHLLLADISEVKNYFSCHKKELEKSYERVWSTKPVTAREGPTLLLGAVPASESQLRAGLPPKPSVFTLCSRYFNSMERSVSIIHAPTFLHQLRSHWDDPCRTPIMWLGLLYSILCLAMLSFHQVGDEPPEWKGRTLELASEFRLRTVQCLIRADYTKPVEYTVETMILYVFGEYSSRWDVDLGLWLIVSSMTRIAFRMGYHRDAKWFPSLTPFQAPADFRGLTGRQEMRRRTWALVRICDVVFSLQVSLPGMINEHDCDTQLPNNLYDDDFDPDTRELPPSRPNTEATPTSYIIAKARLCNELGNVLQATNKVGRNISYDDILQFDAKLRQVAQELPPHLKISPLEESRAPLTLIVARFSIDILYQKTLCLLHRKYMSKARQNPRYAPSRRRAIEASLQAMAHLQTLHRESRGNGRLRAVAWYVKSIATKEFILPAMLIVLDLHFDNMARQSGAPLDHDGAFLWSLEERSSMISTLEEAACIWRSLADSSMEAFKAAKVVDIVLNKMRDATRTSNATSCEQTSPQTSMVANAGATPTGSPNTISPEYFVASNDMMNSFSNVSSSAFLGMEFSLPLPNMADVQAAGLNTAGSASALDMFSNLGGAATDLSSVGIDWNAFENYTQMAGWGTDQSAQLFGAADASSEQEPGLRHVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBC2</accession>
    <name>A0A367LBC2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7438</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBC2"/>
    <dbReference type="OrthoDB" id="3599317at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="122" mass="14040" checksum="0716793C3EB65C1B" modified="2018-11-07" version="1">MGRKIPKNKGEVVTYRYVRVLQVGTLKYLEKIISISFSHLLNTNTSPASNSSSIASFRPSRDSSSSSLSPRVQLSDSGYLYTFNQLFTAFLFLHRPTKYLIRFHFSDAFQQTYPLFPHIFPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBC7</accession>
    <name>A0A367LBC7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7434</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBC7"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI11714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="68" mass="7545" checksum="FED8258C011F0C10" modified="2018-11-07" version="1">MPAAKRRSICLRYSVPGHFLKSCNLRLARRPSISRPDYIAPLNSCFLDSSAIGEYPLSIGTYSSLARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LC43</accession>
    <name>A0A367LC43_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tat pathway signal sequence</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_4583</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000008">
        <property type="protein sequence ID" value="RCI11984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LC43"/>
    <dbReference type="STRING" id="1330021.A0A367LC43"/>
    <dbReference type="OrthoDB" id="5296155at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI11984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="37919" checksum="844F040C347706B9" modified="2018-11-07" version="1">MAAPIYNQRSSNSSGSSLPTMRTMSIITQYSDAYNPGALPKGPLRVPKRQSRRDPALSVYSQQSPYVSPEPSVAAEKDSSTGKEIEAEKGLSAEKEQVSPPRAGTGSGDSARSVSSECSIRDDDKGLFAHRKRAGRFLVAVAIVAIVIVALAIGLAVGLRKRGGTTGSDPFGLGVEFPAGSYAVRASVKTTEAGCTSQPSTWRCDSSGNGASVTAHWDIRSRGHGVFTISSPNDSELNPAFSDVSLSVVDANRLTERLVFTIPMNKTVIPSGGASPTSRAAQCLYQNVEMEATLYTRQRGGRTMSAPSQLGQGVDWPGDVEINQHMPSTIGQPTCRDSGGVQIADVQASQGNCACVYSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCS0</accession>
    <name>A0A367LCS0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1357</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCS0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="136" mass="15476" checksum="3C9240CDE4B4A3ED" modified="2018-11-07" version="1" fragment="single">EIRIELYSGLQIEYYSTKRGPAIRRRVLAASPAIITPYSSGTILTLVNNPPIDRDLIFFPNSLLLSGSIIYDYFYVTVFNSSNRLISFKRKEKISDPVPPINIPDPIPNILEIEGEYGVKIYTLNYDLASKVNYEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LD73</accession>
    <name>A0A367LD73_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LD73"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="97" mass="10476" checksum="F6B4B751A10A7783" modified="2018-11-07" version="1">MPRSSMPAYILIHLDRSPSPLLIGTMSSWASFDGIARMLSTRGSMQATSGSGPWPILPTPTYLTLPPTVRSTTIPTMDSTNPGSWFLPRLPGSKTTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDB4</accession>
    <name>A0A367LDB4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDB4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016587010" evidence="1">
        <location>
            <begin position="20"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="153" mass="16571" checksum="C8E3B0E98AD53911" modified="2018-11-07" version="1">MTPSASGSFFFFALVGLHARFSGHIVLEGFIIRHALQSSQPACALFSPNSGGGGPEPLRRQKFYLLARILAYSPKEADYNTERERIVRTYGSGPYRAYYLSISPEVPPLLTSISLSPSPDPPLPLPSPPSHAITASGRSGLHSSFLYSLYSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDF1</accession>
    <name>A0A367LDF1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Actin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_1140</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the actin family. ARP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDF1"/>
    <dbReference type="STRING" id="1330021.A0A367LDF1"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd10216">
        <property type="entry name" value="ASKHA_NBD_Arp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000018">
        <property type="entry name" value="Actin-like protein (Centractin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI12446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="40079" checksum="E7389225CFA413BA" modified="2018-11-07" version="1">MPELHNAPIVLDNGSGTIRAGFAGEDVPKCVFPSWVGRVKYLRVLAGALEDDVLIGKDAAAEHRGLLKIRYPLEHGIVTDWDDMERIWEHVYSDALKTLSEEHPVLLTEPPLNPRSNRDTAAQILFETFNVPALHTSIQAVLSLYASGRTTGIVLDSGDGVSHAVPVYEGFAMPSSIRRIDVAGRDVTEHLQTLLRKSGYVFHTSAEKEVVRMIKENVAYVAKDPRKEERDWIGIGSERFRAPEILFEPELIGLEYPGVHQMTVDAIGRTDLDLRKSLYGNIVLSGGSTLTKGFGDRLLTELQRLAVKGMRIKIFAPPERKYSTWIGGSILAGLSTFRKMWVSIDDWHENPDIIHTKFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDF4</accession>
    <name>A0A367LDF4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDF4"/>
    <dbReference type="STRING" id="1330021.A0A367LDF4"/>
    <dbReference type="OrthoDB" id="5365739at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="294"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="434" mass="47551" checksum="626D79A10927882D" modified="2018-11-07" version="1">MLMGTATRRQMLRLRDVWARSIAWKQKSFSTSQWLPAEGDEKPTMRQKSQAMVGEMASVLKEKRDHEPQKALEHSASTLSRTNNLNVTMIPEGGIRSLGRRGRFSGLRAPGGMSANNARSRRGWRKGKNGEGEGEGEGEETSKRQPDSDGMTVEERILDRRLRFGETAVYKPSLSMSDLELFVPAEPSSAAGRQAIVLENLCILARGNSVGVGANLGRHFDARMFLTHGMRYFADLKDRNAAERYLRSRRAKRNRRSARPRASRSRRRRRGRTAFATSGTNPQGEQQGQNEADATTGGQETAAKGEGAGAGAAETQGEAAAGRPSFVPSAESFQKAIMSCATQDEAAAKRDERPRCRPIMQPADVSIRQVIVDRAIVGNYEKPVFAIDAAGIARSWHLRSGTYGSKDVESFERKLLSLLGPETMGSGGSQPTAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDH5</accession>
    <name>A0A367LDH5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1169</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDH5"/>
    <dbReference type="STRING" id="1330021.A0A367LDH5"/>
    <dbReference type="OrthoDB" id="4920918at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="146" mass="16359" checksum="A23DF01605DB06CC" modified="2018-11-07" version="1">MWLTGSTMHCHQTPSRRFQCDEDQRFPQRETSPESRPYLTENRSSPTYPLSSYTKQNKTVLNSKEATMKNVSAQLLLLLLPSLASFTAGSPPSSTKIEARDNCFHPSSCSASWAGKCEDYCGSRGFSHMTGDGCGWFQKKCCCIRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDJ9</accession>
    <name>A0A367LDJ9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_0173</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDJ9"/>
    <dbReference type="STRING" id="1330021.A0A367LDJ9"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI12496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="182" mass="19039" checksum="B254954C6B386AE5" modified="2018-11-07" version="1" fragment="single">CFREAPDLFLTIEGHRRQAIKEGRCYTCGIRQTSAIEASPLLKPLPPLLLTPLPPPPPPPLTPLPPFPLPLSTSMPLLAEWLAAKKALVDIPPAARLAVPTPLPPSRRPVYRLTPSWQPATPPISTGVIEAAAIGPYRQALLTTIAAALVPLASFKAAAAASASEATAASGAAEEEETAEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDP6</accession>
    <name>A0A367LDP6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein SSH4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein ssh4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">L249_1188</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Components of the endosome-vacuole trafficking pathway that regulates nutrient transport. May be involved in processes which determine whether plasma membrane proteins are degraded or routed to the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SSH4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDP6"/>
    <dbReference type="STRING" id="1330021.A0A367LDP6"/>
    <dbReference type="OrthoDB" id="258495at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12910">
        <property type="entry name" value="SPRY_SSH4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.920:FF:000065">
        <property type="entry name" value="Ear1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035780">
        <property type="entry name" value="SPRY_Ssh4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="domain" description="B30.2/SPRY" evidence="18">
        <location>
            <begin position="81"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="321"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="338"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RCI12536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="505" mass="54719" checksum="6580AC417513E5D9" modified="2018-11-07" version="1">MTVVTAPSSAFTGIIIGLVSSFGSIILIGLVVFVFWASGCAGSGRILLDRLGRPGEYDDEQAFAREEADALETMDEMSRTEYLRAKAFVTANPPESLQTDISLSQYLAIQEKGISAWEFEPELEIANCFVEARTEIEFFDSECTVMSNLPVPKQNDVYYWEAKIYDKPDNTLLAIGMATKPYPLFRLPGYHKYSVAYHSDGSRHYNQPFSRTPYGPHLVQGDVVGVGYRPRTGAIFFTRNGKRLDEVVHGLKSQNFFPAIGANGPAVVHVNLGQSGFVFIEANVKKWGLAPVTGSLAPPPPYGSEQGSILLESGTKDGVVPGHQSVTGSPYHVHRGGSNLNTQQHGRSRSGNFRVLHPTSPGPLRSPTDISLAQLVPNSNNDGGNVINNNNNNNNNNNNDEVGEASGGAAALRRPLHHQQQQQGEDPLHLRLEDATNPPPDYASPAHSDEDSGGSPRSSTDSENAPLISVMNRAFPATPSRRPPVPSYSDAVGASPERSASRREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDQ6</accession>
    <name>A0A367LDQ6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase II holoenzyme cyclin-like subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_0336</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family. Cyclin C subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDQ6"/>
    <dbReference type="STRING" id="1330021.A0A367LDQ6"/>
    <dbReference type="OrthoDB" id="10266018at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20513">
        <property type="entry name" value="CYCLIN_CCNC_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028758">
        <property type="entry name" value="Cyclin, C/H/G types"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0195">Cyclin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="53"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI12563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="321" mass="36526" checksum="481E4F7FD87B71ED" modified="2018-11-07" version="1">MSANYWESTQRRHWLFTKEHLAAMRQKLEEDNADLVRMFPLPQPRHLAIFFNQQLLRLGKRLSIRQQAMATAQVYLKRFYCRVEIRRTNPYLVITTAIYLACKMEEAPQHIRLIVTEARQLWSEFIGLDTSKIGECEFYIISEMSSQLIIHQPYRSLTALRGELALADEDVHLARSVINDHYMTDLPLLCAPHIIALIAILLALVLRPNPSGSGQAVSSTAAAAGLVAAQAALSQAHSKASGLKNMVEPPNPSDSKEKQQEARITRVQHFAAWLAESTVDIAAMVDATQEIISFYEFYEQYNDKLTREQITRFVKAQNLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDS4</accession>
    <name>A0A367LDS4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDS4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="126" mass="13755" checksum="F9F34EC5C2ACE069" modified="2018-11-07" version="1" fragment="single">MYVDGNPIKGRGAVNTYIHTLVVKSPSSTSKRKRASASSYFLSTANPAYARCVCSPPSHSSGVLLAEDKTDVENKDNEHRHREAAPTSPVGRKKNIIKKTMGKRGSTNMLICLPRPARNKTVNCLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDZ9</accession>
    <name>A0A367LDZ9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1275 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDZ9"/>
    <dbReference type="STRING" id="1330021.A0A367LDZ9"/>
    <dbReference type="OrthoDB" id="5288586at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488:SF7">
        <property type="entry name" value="DUF1275 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488">
        <property type="entry name" value="DUF1275 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="27209" checksum="D9D3BBBAA7AE1F27" modified="2018-11-07" version="1">MSEPEPEDSQLKQRRGLAGWILQDVDVRLAYLPLLACCFISGLTDGTIYNGNTVFVALGTSGQNNKPYGWARSLCSIVFFVLGSFTFARLYQLLGGRRRGTLTLSFLSQACIVVVAAAMVQGGVIEGRYPSTRSTTRVDFKELIIIALLSFQAAGQIVSSRSVGVGEVPTVVVTSMLCDLVSDRGLFSLSPNEKRARRFCAFVLTLVGAICGGWISKAAQAVGPSLWTVAAIKLVIALLWAAFWRGEETIGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEB3</accession>
    <name>A0A367LEB3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEB3"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="244" mass="25439" checksum="2405D872D15CDC49" modified="2018-11-07" version="1">MRRPVSESYSHKDDKTTTPQRLDSHLLDPFQRGVSTDEAGSVDEDTSRYTGDTAEVLVANAAPGLGQWLAADEGAPGFGHALDHPLGRRVGLLAVQDVENVGRGSGVLNSEEVILPRRRKQVVAVKDEQASLGVVTEAVLVGASDDGAGGQPSTEAIVELALKLLADAGAGGKEAFILKLLRRLGVGGGRQDGRVVPRGVVAHHDGGEAEAGLVEARNNRGGLEGGRIVDIDAVVVRVEGLDEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEV2</accession>
    <name>A0A367LEV2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol-4-phosphate 5-kinase</fullName>
            <ecNumber evidence="2">2.7.1.68</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">1-phosphatidylinositol 4-phosphate kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Diphosphoinositide kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">PIP5K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_0101</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14425"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.68"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.68" evidence="2"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEV2"/>
    <dbReference type="STRING" id="1330021.A0A367LEV2"/>
    <dbReference type="OrthoDB" id="20783at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17303">
        <property type="entry name" value="PIPKc_PIP5K_yeast_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.800.10:FF:000009">
        <property type="entry name" value="Phosphatidylinositol 4-phosphate 5-kinase its3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="13">
        <location>
            <begin position="326"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="37"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="593"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="737"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="66"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="158"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="737"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="770"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="813"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00078403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00080374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00082306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI12953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="934" mass="103698" checksum="297943353D1C9DF2" modified="2018-11-07" version="1">MPLFVADDPSPVSSAGVNVLSLGFTDENKANVAAVRSRHGISKESFDESSASSSDASDLTPMPLNGNVTLSTSMSSLANSKSLVADPPKTGGKPLPPPNGVTVLPDRTLPPSPRVNGHGSTPSGRRQVPESPTRPPPERPMSADGDDSKRNAGNAYHDDDDDDDDDGETSTPTETDFRNGQTKSQLHRFSSPPAIPLTHPPPSSTTSASGHLQPPQAQLTLKQRHTLEVPKPPSGRHSRDGADVVFATGRFSPGANGGPSNRRASLNLVRRTTRSVPSDFPRDEVAPDEDALRWAEAYRQKRASKRKRKEEEDDDRVLVGTKVDESHANWVTAYNMLTGIRVSVSRTNAKLDRDLTDADFDAKQKSTFDITGNELVPSAKYDFKFKDYAPWVFRRLRALFRLDPADYLVSLTGKYILSELGSPGKSGSFFYFSRDYKYIIKTIHHSEHKFLRKILKEYYNHVQQNPNTLLSQFYGLHRVKMPYGKKIHFVVMNNLFPPHRDIHQTFDLKGSTIGRDYKEADLARNPRATLKDLNWLRRKQHLELGIQKKQLFLAQLQRDVVLLKRLQIMDYSLLIGIHDVSRGNEENLRDKTLQVFSPGGEKSSDDDPKSLLRTPSKLENVRKARELRQMIRQERPVPMGQASARMPDELDEGQSRSGFVFHQDDGGFRATHEDNAPAEEIYYLGVIDCLTHYGMIKKIEHFWKGLSSDRRQISALPPEEYGDRFFNFIEGVTMSAEEAREREQRRRQEEAEAEAREASAAARSSHLGIPPMPDHQPPAPPMASPTREGQETLELASREARRTSAKGAAEQDIPERTLRATSDKRDSLHEPILPVVEEVGEQGRTEAGDGASRGHSSSAAVSPPASGPPPKCHGQLKTDSSDSGYGGLSNGSVSRDGSVKMRPRVSRESLNKRLPPLPGEEEQKQKTSGVKVVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEX2</accession>
    <name>A0A367LEX2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_0480</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEX2"/>
    <dbReference type="STRING" id="1330021.A0A367LEX2"/>
    <dbReference type="OrthoDB" id="346907at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43289">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43289:SF6">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEKL-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="304"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="210"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="212"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI12973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="604" mass="67132" checksum="4C0CE9A750AC1FAA" modified="2018-11-07" version="1">MTEASEEATEPLSQPVFEGGERGFGLDEPVTPLDDSPVSLDALVLEDHHHRQGIRILVRPLTKLPGVNPGGDHCQWLALRAEVASSDQPQHKVLAVTHTAKNINFSLRIPGISSRPPLWCDLYFDPGSEKLILLNKSDIPLELELANGLHHRQQHHQLATPPPPDHVVNPGLAQALIPGTWRIKVRHVAVLDFRILEKRPVTLYQLVDDAPSDSASTSSSSGKRSLTMDDDFGSRAKRRISDGGDDGDDDNGVIMFLGPSVEPLVFPLPKSRELSAVNSHALLDANEGETVSVPGVCEVDTYQLTKGDPIASTALSAVYKAKYSKVPDSIVTVKVLKTVASANSDKPLAHERNVIRQADVWLRESQSQDDLKHDSIVRYYGGDARFLSLYMEHVEAPDLASGRWRNKTDEFTGTYDDALRILTDMSRALGYIHDRQLVHNDIKPANILYSPHRGAVLCDFGLLNSAANAAHSGGTPYFIPPEFIGTKLRGYPSDVWALGVTMLYVLRRIPLPDSRARRNHPKRLYWMINGVNNPSLVHREGNGQPAAKQMRDWLTEIFDAREKLNARDRLQRIVKEMLVPSPNQRITMARVLQELQSEQTVVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFE2</accession>
    <name>A0A367LFE2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CAF1B/HIR1 beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_0242</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat HIR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFE2"/>
    <dbReference type="STRING" id="1330021.A0A367LFE2"/>
    <dbReference type="OrthoDB" id="71227at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033186">
        <property type="term" value="C:CAF-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000461">
        <property type="entry name" value="Chromatin assembly factor 1 subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055410">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045145">
        <property type="entry name" value="PTHR15271"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271:SF4">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24105">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="11">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="59"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="117"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="159"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="11">
        <location>
            <begin position="304"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="199"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="410"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="554"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="642"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="246"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="584"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="670"/>
            <end position="684"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI13143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="702" mass="74368" checksum="78F3FED92632BD6D" modified="2018-11-07" version="1">MKATPIIINWHDQNAPIYSAHFESSGKGRLATAGGDNHVRIWKLESDGLDRKVEYLSTLSKHNQAVNVVRWAPKGETLASAGDDGNVILWVPTDLQPSALGSESHDDKESWRAKHMCRSSGAEIYDLAWSPDAAHFIIGSMDNIARIYNANTGSLVRQIAEHSHYVQGVTWDPLNEYIATQSSDRSVHIYSLRTKDGQYTLSQDDKPPRLASHIKADMPPRRISSNSPAPPDFGHRNQLSVIDSNTSAGSPTASAPGTPSSFAVPMNPPSVVSHSRRSSFSSRRSVSPAPSMPLPAVMPMEASPKPHSSAVKNASLYANETLTSFFRRLTFTPDGSLLLTPSGQYQTQVQSDKDSKPTLEIVNTVYIYSRGGINKPPIAHLPCHKKPSVVVKCSPVLYTLRQSSISTKHITMDTSSAQESLAPLPDPVSKPSSTPSMMDPPPPPGSASMDSPAKTASIGADASTAGPKPAFSLSYRIMYAVATQDAVLLYDTQQKTPICIVSNLHCATFTDLAWSNDGLTLVITSSDGFCSTLSFNASELGEIYKGDAKAQVGASSHNTPATSFAPLSPFPSGAHHQHRTSAGSFTAPSPPASVAAMAQRPSSPTRSNSASSIATQTSLVPGGVVSNPPLIAGSMPALTASGGGKAVGAKAGGVPMTTPPETPRSTAAGVKREASESEREEGKEPKRKRVAPTPVDSNSKPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFF9</accession>
    <name>A0A367LFF9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U3 small nucleolar RNA-associated protein 11</fullName>
            <shortName evidence="6">U3 snoRNA-associated protein 11</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_0642</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the ribosomal small subunit (SSU) processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Nucleus</location>
            <location evidence="2 6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the UTP11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFF9"/>
    <dbReference type="STRING" id="1330021.A0A367LFF9"/>
    <dbReference type="OrthoDB" id="29058at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007144">
        <property type="entry name" value="SSU_processome_Utp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03998">
        <property type="entry name" value="Utp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015952">
        <property type="entry name" value="U3snoRNP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="159"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="188"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI13159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="244" mass="27682" checksum="925F260F11575A97" modified="2018-11-07" version="1">MSASMRNALQRRPHRERAQPHERRRLGLLEKHKDYALRAQDYNKKQAQLKALRQKAADRNEDEFYFGMMSRKGPGSRIMDGPSWRGTVAGDRGNKVLSVETVRLLKTQDMGYIRTMRRVLAKEVSRLEQQIVVSRTVCAATASHPRKIIFADTVEERSQAVGAAEAEAQHGDDDDDDDNDDHNHNTAESEPSLEQQLQNARKKLQALTDAEDELDVQRAKMAKTATSGGETKQGHKIKVRARKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFS2</accession>
    <name>A0A367LFS2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_0657</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the early part of the secretory pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the KISH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFS2"/>
    <dbReference type="OrthoDB" id="5377952at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009100">
        <property type="term" value="P:glycoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048743">
        <property type="entry name" value="AME1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051523">
        <property type="entry name" value="KISH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009653">
        <property type="entry name" value="Ksh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007074">
        <property type="entry name" value="LicD/FKTN/FKRP_NTP_transf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13229">
        <property type="entry name" value="PROTEIN KISH-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20994">
        <property type="entry name" value="CENPU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06842">
        <property type="entry name" value="DUF1242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04991">
        <property type="entry name" value="LicD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016685713" evidence="11">
        <location>
            <begin position="23"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="12">
        <location>
            <begin position="236"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="12">
        <location>
            <begin position="330"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Inner kinetochore subunit AME1" evidence="13">
        <location>
            <begin position="702"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="443"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="512"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="764"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="534"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="571"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="637"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="656"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI13284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="890" mass="99557" checksum="44BBECA4B4152992" modified="2018-11-07" version="1">MSALFNLQSLMLVLLLLTCTSAYIHHMFPRLLDSNKDGPLGILWKFARIGERMSPYVSLACVFMASTDEEMNVRELIDCLADIDGNLWEKGKACFVSCRIPYEAAPDAKDVAKLSSAPNRRLSAADQAMLCAVLLLLVSAVTGLVRRDAVPVDEDLYPEPKYFRNPFYARDTHSHTDVLFTQRPCTLRCAFHGPGSRRGTAPRRSSDSHPDLLGNLSRTRRADLADARKPPRLVIMPWDMDADVQVTEVDLYYLAAHHNMTVYYYKYGDMKDGRYFLLDVNPHFEHRDTDDSLNLIDARWIDMATGLFIDITAARYHLEHPAGEGILYDKNGHEFRDTYVYPLRNTTFEGVRAMIPFRYKDMLESEYGKESLRDTTFHGHVFDEKKMQWVLESALYKFPGYPVLSRSRRAERLNERLRGAQRVNVDDDSFNLNIDGLASAPTADVEATAAPPLPSSDRKRKRAPDESDAEPVRNGIKSPVRSRISAVVIEEEVGESPSHAPGSGRRRKVLLGEKGTDATPPPSSPLARRARHVTPSTPTLVPTPQQPQTDELSPDQGGELPAVDRLVDAEASAEEAEEIDPVETARVLGKNSSRHAPRSSPELGSAPVEAEEEEPRLQKRAGKKGSPAKQKQPAKGPPRRPKQKAPVKQGKKTADDDKDGDGDDGVEITVQRFVKKRGGDADDADPLQSDMAFANRAGESVVDVFAQVCEEVVASTLTQLQHLLDTAEGPAKKKECRIKMRAIEAYREELRSRLLQHAIHLNHWHTLRKQVRKAQKEKLALREEIIRLNGEREQVALRMDAVRIKHETNSKESTRRINTSALMHDIELAVEQGRDAPEVSRQVQRQANLELLIAQVSDLASSGSSTGGLLHQVRDFNAFLERAALALESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LG77</accession>
    <name>A0A367LG77_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Very long-chain fatty acid transport protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Very-long-chain acyl-CoA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">L249_5614</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Acyl-CoA synthetase required for both the import of long chain fatty acids (LCFAs) (C14-C18) and the activation very long chain fatty acids (VLCFAs) (C20-C26) by esterification of the fatty acids into metabolically active CoA-thioesters for subsequent degradation or incorporation into phospholipids. The transport and fatty acyl-CoA synthetase activities are genetically separable and are thus independent activities. Esterifies VLCFAs in the peroxisome matrix. The VLCFAs are actively transported into peroxisomes by a PXA1-PXA2 heterodimeric transporter in the peroxisomal membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:54536"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:58950"/>
            <dbReference type="ChEBI" id="CHEBI:138261"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Lipid droplet</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LG77"/>
    <dbReference type="STRING" id="1330021.A0A367LG77"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044539">
        <property type="term" value="P:long-chain fatty acid import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000019">
        <property type="entry name" value="Long-chain fatty acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF15">
        <property type="entry name" value="FATTY ACID TRANSPORT PROTEIN 3, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0551">Lipid droplet</keyword>
    <keyword evidence="13" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="21">
        <location>
            <begin position="55"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="22">
        <location>
            <begin position="491"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="572"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="591"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00068795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00078285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="RCI13426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="651" mass="71155" checksum="2067746D3D64EC19" modified="2018-11-07" version="1">MSAILPLSAAVALTAYIDARASLWYDRRIISSACRTALRLYLRSRRGRLNLFYDLEDRARQTPSHPLLRFEGATLTYGDIYDRVLRYGAWLRSRAAVEPGDVVAMLLPNSDLFIVVWWALWSIGAKPAFINTGLTGVSLAHCLRVSGAQLCLSDPDLAPNVAEAPIAVRLLVFDDEKQAEALAHPADRSPDKDRYADNAVAMAMLIYTSGTTGLPKPAVVSWYKCVAGASMAEMLVGRGGPDDVLYTAMPLYHSAASVLALGSTVTSGATLALGRRFSTSRFWDEVRATKATSIQYVGETLRYLLAAPARPDSDRRHSVRTAFGNGLRPDVWNAFRARFGVETIVEFYAATEAPLAFWNISRNDLTAGAIGRHGWLYGALQRLRIAVVDVDWAAEAPRRYSPDGFCRRVRPGEAGEMLARLPAGDVRRAFQGYHGDEAATESKLLRDVFCRGDVWFRTGDVARWDADGTVYFVDRIGDTFRWKSENVSTAEVQDTLGRHPLVLEANVYGVSLPNHDGRAGCASVCLAEPESTEPSGDVLRSLAAHVRATLPSYARPLFLRLVPVVGQVGHTTATNKQQKHHLRAAGVKPASLSSSSSPSSPSSPSSPSSPSSPTSPSSSSSDDRLYWLRGDTYVPFREPDWHALEAGRLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGK4</accession>
    <name>A0A367LGK4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_5596</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGK4"/>
    <dbReference type="STRING" id="1330021.A0A367LGK4"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050775">
        <property type="entry name" value="FAD-binding_Monooxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098:SF3">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="8">
        <location>
            <begin position="42"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI13548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="570" mass="63795" checksum="D685947307F43F14" modified="2018-11-07" version="1">MSGTTLSNGGRLRTEITDLRDIRPDSDSGANPSSEDAPVDLDALIVGAGFAGIFMLKTLRDRGYGVRIYEAGLDLGGTWRWNSYPGAAVDSEVPHYEFSWPEVWEAWTWSTNYPDYAEIRAYFDHVERVVGIKKDCRFGTVVTGASFDTDAGRWSVVTSDGRTTRAKYLILGTGFAAKRYVPDWPGMANYRGIIHHSSFWPEEKVDVERKRCAIIGTGASGVQMAQAWGPVAGSLAVFQRTPNMAVPMRRRQLSLEGQQHSKTYYPELFRYRERTFSGFCFHFHERRAADETAEERQAVLERSWAAGGFRFWLTSYVEGMKDPVLNSQYYDLWLRETRSRISDPRKRDLLAPLKMPHYFGMKRPCLEETYYEQFNRPTVDVVDIGSDPIECFTETGIKLKSGEHHELDVIAVATGFDISTGAMTQIGLVSIDGTPLDQLWAKGATTYLGLTVSGFPNMFHLYGTHAPTLLCNGPSCIEVQGRWIADCIDKVERSGIKFVNARPEAARAWKDEVVDINNSTLFPTTRSTFMGGNVPGKPFEPVAYAGGLCNYAETIRAALDSMEGFDLVYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGT6</accession>
    <name>A0A367LGT6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WD repeat-containing protein JIP5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">WD repeat-containing protein jip5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_5557</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat WDR55 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGT6"/>
    <dbReference type="STRING" id="1330021.A0A367LGT6"/>
    <dbReference type="OrthoDB" id="2288928at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050505">
        <property type="entry name" value="WDR55/POC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44019:SF20">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="141"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="338"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="342"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI13630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="424" mass="45500" checksum="D5F8B9BBF65E49F9" modified="2018-11-07" version="1">MFENLCTLPLPADVFTTAVHPEEPLLTVGLASGHVETFRLPPAGSSSPRDNTIESLWSTKRHKGSCRCLAYSYDGKAIYSAGTDSLIKHFDPSTGQVISKALIPSASSIPDAPCLLHALSPQSLLLATDSGALHTLDLRDAKPDSRPSQTHFPHADYVSSLAPLPPSEESTSGVPKQWVSTGGTTLAVTDLRRGVLVRSEDQEDELLSALFVPGLGRKRNCANGIVAVASASGVLTLWDRGAWDDQQERIVVDRDGRESIDALVRVPPDMGLGAHKVVCGVGDGSLRIVDLARRHVDVSANLRNDDTEGVVALTFDPHNRLISAGGRIVKVWEELSDLQHNDDDDDDDSEDGDDDSDNEDENAEDETTDGAEHHACKSGKRAVDGQADDGVADMKRRAKRRKETRGSKLGPMGAHGIMAFDGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGT9</accession>
    <name>A0A367LGT9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_5469</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGT9"/>
    <dbReference type="STRING" id="1330021.A0A367LGT9"/>
    <dbReference type="OrthoDB" id="2155291at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000935">
        <property type="term" value="C:division septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04399">
        <property type="entry name" value="RhoGAP_fRGD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000044">
        <property type="entry name" value="Rho-gtpase-activating protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000050">
        <property type="entry name" value="RhoGAP and Fes/CIP4 domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000591">
        <property type="entry name" value="DEP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF17">
        <property type="entry name" value="RHO-GTPASE-ACTIVATING PROTEIN RGD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00610">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00049">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50186">
        <property type="entry name" value="DEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-BAR" evidence="6">
        <location>
            <begin position="2"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="DEP" evidence="4">
        <location>
            <begin position="255"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="5">
        <location>
            <begin position="488"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="183"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="697"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="99"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="714"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="732"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="800"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="894"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI13607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="894" mass="99686" checksum="D67117820527D74C" modified="2018-11-07" version="1" fragment="single">MPGFADSFWSSDYAAGLGVLFGKLQQGVLENRQILTIARLRAEAEDTYGQRLKDIAPAADKVNGGFARDDGATVRKVSFPFVPRCQIIFMLIICFPQAYEGMRNEMQDAARNHQRIAQNVRDLVVNPFSRWCDAHEARVHDSQEELQGLLKAHGRQVDLVQKLRSTYFNKCRLVEDLEEENKLAFQDPETSPKPNKPIPEIKVQPHKEEESDDDEMYEIGDDLYQPEQLRKFLAPMLSTVKTGETKVPILGTYLNTSAGSDIVEYLQRNLGVSSVSYAERIGQDLVSNGFLRLIGNVGSTFANSSRLFYQWRPKAFKMAGIAERKQSLSRTLSLPTDGGDSPVVGTVSEYLANWNVLNNSHPNESPAQRLLRESREADDKYKAAVSKLDELRCELEEAIFLHLKFLERCELDRLKAIKTVILDFSGSIGNVIPSLQSTVDRMLLFQETVQPLGDLRYLLENYRTGKFVPRVVTYENYYNRIDEQTFGVDLEARARADKKRVPMLVTTLLTYLDHHYPDLEGDEARRGVWLVDVPLVQTHKLRAMVNNGKPVSQEALGQFDIPTVANLLKLYLLELPDSLISSHVYDMFRTIYSTPSSADASDASRISVLQQTLSQLRLTNIATLDAFMNHFTRLIDLTSADETYVSALASSMAPYIMRPRMETSLTMEEKHAAKLIRDLFTHKDAIFNELKRMSTLNNTSSIGSTRPRAVSTDESNRKALVEERNRALVEKASASRSRATSPAPSPRGHRRDRSSCAETRFPVQASPPSGGGDRQRTSLGSIDGRLKRSSLDVPGAETIDATSGSSRTISDGDAAMDPHESSLARGGLKLVSGRGITTSMPPDFAPRGRDVGGQAHGRLVIRCCGHSPPPPLSPLFFLLSSLESALHFGFCHTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHT7</accession>
    <name>A0A367LHT7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Zinc/iron permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_8005</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHT7"/>
    <dbReference type="STRING" id="1330021.A0A367LHT7"/>
    <dbReference type="OrthoDB" id="19859at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006829">
        <property type="term" value="P:zinc ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045891">
        <property type="entry name" value="ZIP9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 39 ZINC TRANSPORTER , MEMBER 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16133:SF0">
        <property type="entry name" value="ZINC_IRON REGULATED TRANSPORTER-RELATED PROTEIN 102B, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016869207" description="Zinc/iron permease" evidence="8">
        <location>
            <begin position="18"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="235"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="361"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI13812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="381" mass="40410" checksum="F5517DA66A70160B" modified="2018-11-07" version="1">MAGIILLLGLSVVMALASFLAGALPLSMTLSQSQLRLISSIGVGVLVGTSLMVIIPEGIEAAATPAMATSHHHRSRLLAQRAPWTLAMTPRHTVESIQVARDAPAEMVAPDLPEVQTPSLDDKTRDETCRAEIPSFEVGFSMVLGFVLMFLIARLPRHATDTFHSVPSTTHMSLDNLGVDGAAGDDEADSFLGSLTPTPRRARSLATTVGLVIHATADGIAMGASSATSNVHLGLVIFIAIMIHKAPAAFGLTSVLLRQGLSKRAARGHLIVFSLAAPAGALSTWLFIRLLGGDHLEGEGGQWWTGMLLLFSGGTFLYVAMHAMQEDAASHHYDHGSGVNGYADGSSIYPRKSRGPQMRETLATVVGMFLPLLTLFGHHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHU1</accession>
    <name>A0A367LHU1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7917</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHU1"/>
    <dbReference type="OrthoDB" id="3599317at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI13995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="31" mass="3377" checksum="82DD64CD58897C3B" modified="2018-11-07" version="1">MDSLLIREKLQGALGSIAHNKSEDALALIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LI09</accession>
    <name>A0A367LI09_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Cytochrome b mRNA-processing protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_8035</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 11">Essential for the assembly of ubiquinol-cytochrome c reductase. It has a direct effect on the correct occurrence of the Rieske protein, core 4, core 5 and apocytochrome b.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the CBP4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI14049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LI09"/>
    <dbReference type="OrthoDB" id="5576752at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012420">
        <property type="entry name" value="Cbp4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28202">
        <property type="entry name" value="ASSEMBLY FACTOR CBP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28202:SF1">
        <property type="entry name" value="ASSEMBLY FACTOR CBP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07960">
        <property type="entry name" value="CBP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0143">Chaperone</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="89"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI14049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="119" mass="13815" checksum="60D227358629E7EC" modified="2018-11-07" version="1">MARINWSLWAKVLIGGGLVSVGGPALTMYLTPSEDELRKRYNPDLQKKSLETREERQQEFDEFVTRLKTYSKSEKPIWEAMKEDEQRRKLAALQAGKTQQREADARRDEMRREAGLGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LI20</accession>
    <name>A0A367LI20_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Intimal thickness related receptor IRP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_7937</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LU7TM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI14083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LI20"/>
    <dbReference type="STRING" id="1330021.A0A367LI20"/>
    <dbReference type="OrthoDB" id="19932at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053937">
        <property type="entry name" value="GOST_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009637">
        <property type="entry name" value="GPR107/GPR108-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053938">
        <property type="entry name" value="PTM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229:SF1">
        <property type="entry name" value="GH17801P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229">
        <property type="entry name" value="LUNG SEVEN TRANSMEMBRANE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06814">
        <property type="entry name" value="GOST_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21902">
        <property type="entry name" value="PTM1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016985602" description="Intimal thickness related receptor IRP domain-containing protein" evidence="9">
        <location>
            <begin position="20"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="319"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="364"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="408"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="PTM1-like N-terminal" evidence="11">
        <location>
            <begin position="30"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="GOST seven transmembrane" evidence="10">
        <location>
            <begin position="182"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="462"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI14083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="536" mass="60232" checksum="64DEE7455C3FC311" modified="2018-11-07" version="1">MRLSSSLSFVGLLLWTAGALEVAMDQSEKNRQYCSGMYSRTTWGGPVDPFIEIKFLNSTVPEGSDPITSLIIFEWADKSLVGVPDPNLPGLQLELCHNESVSQGRCNTSAVGEFILAPNATSKSNAVILSKAVHLKEAAPLRYPIKKTGYYCVVTEVFTAEHYSLVTEFRNAYGELPATQIPKLPFYGGMTILYALVCVFWGFLYYQHRHDILAVQNYITAILIFLVIEMLMTWGFYDYQNRIGNNAASKILLILVGVLNAARNSFSFFLLLIVCMGYGVVKPTLGRTMIYVRWLAAAHFVFGLIYAITSLLISPERPFVLLIVLPLAGTLTAFYVWTLNSLNFTLKDLRERKQNAKEAMYRKLWWAILVSILVIFGFFFFNSFTFASVNDPDFVPFHWKTRWFVLDGWLNIVYFGDVVWIAYVWRPTANNRRFAMSDEIGQDDDGNFEIGDIGIPEDFEDEEEAHGGHHQRHQPPATGLTSVARGPTAESQQGGQRRAPGRESMEGETIFAVGEDGDKLSDVASEEEDATLVRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIA7</accession>
    <name>A0A367LIA7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIA7"/>
    <dbReference type="STRING" id="1330021.A0A367LIA7"/>
    <dbReference type="OrthoDB" id="5278722at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="440" mass="48439" checksum="7FE4BF3DA630DC57" modified="2018-11-07" version="1">MGSLRPSKSVDEPPDNPPRCPGIKALLAFATQRIMRGGARSLVLFAAMLLVVPALMRLSPTSWHPSWNRSQATGDSLRIVVFGSQDLLGSASGRPTWTKQLCIELGCSSYVSLVPPAGSSHGLTSNGIYADELGKLQKRMKETDVAKSPAWNYSFVSEQYPVPAQTPDLEAQVKRFLSRRPAAAATSAVVAPHRTLWVFTFGTWDVWNLAALPRELGERAVDALVLHLFSQIELLYGESLHGRSIAYSDFEARVAKPADPGAGPESFRVVIPDLLDVTLMPGWQRRPDPPAPHSKAEQMRNAAFLTRQWNSKVAQELERWVAKGKTKSAVGEEGKEGDLRKPIKGQLMNPPYPRRTGLRSTPAATILDTMTEQEVQRSREQATATVFLDVWKPCVEGDETCSTPDTHLFHDAFTVGQRMAEGAARMTAEKISRELMASVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIJ6</accession>
    <name>A0A367LIJ6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIJ6"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="77" mass="7563" checksum="7876129A928C1BA3" modified="2018-11-07" version="1">MAVVTAVVTAALGSYPYSAVDLVPDPDPDPDPVPDPDPVPDPDPSKAVTKHSSVTYGGLGPAAADPASLSGAPAKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIV6</accession>
    <name>A0A367LIV6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_5955</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIV6"/>
    <dbReference type="STRING" id="1330021.A0A367LIV6"/>
    <dbReference type="OrthoDB" id="5546837at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36460">
        <property type="entry name" value="UPF0132 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G10255)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36460:SF1">
        <property type="entry name" value="UPF0132 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G10255)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="478"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="502"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="302"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI14366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="545" mass="58904" checksum="72AF2057BD8FD13D" modified="2018-11-07" version="1">MISGPSSSPRLWLRQLGSRAPWRISSNQKLSTSTRHAASIEAIPSTQPPSARPVETRKSQLIRTYTSLMRSSPVILLFQHSNLTADEWAAVRRELKRAVTAVNSAGQPDLANLVQLQVIRTNMFNVALKIIEFFTPEAAAAGSASRLGEALTHDLSEAAYKAMREAKPPPTSSYAQIEPLMVGPLAALALPVISPAYLAAALTVLAPVPGKFPAPTRRKCPGYHDPVCQNGLAKLVLVGGRIEGKVFDQAGVGWVAGIEGGLDGLRSHLVSILQGTGLGLTTTLESGARSVWLALEGRKKQLDEGGAPAKARRRKAAAWNQGRTFTDRRDDTLPPLRHRPLHQKTLPNKKRKGRATAMDFAPYQSSPPEHSRVASPESVTSPRPSLDALAASRKSPPPLQHPQPRRAWGGDLDGHTADGGGGGGGGVWASNDLSEFDTSLGLRLDYEACLAYLALPPLGAIVLLILERNSDYVRFHAWQSALLFTAILVLHIVISWSSFLSWILFFGDVALVALLTLKAYRDAETLDRFEVPLFGTIASRILDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJJ9</accession>
    <name>A0A367LJJ9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA polymerase delta subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJJ9"/>
    <dbReference type="STRING" id="1330021.A0A367LJJ9"/>
    <dbReference type="OrthoDB" id="337486at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000731">
        <property type="term" value="P:DNA synthesis involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007218">
        <property type="entry name" value="DNA_pol_delta_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14303">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14303:SF0">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04081">
        <property type="entry name" value="DNA_pol_delta_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="23371" checksum="693A51CFB11CE22A" modified="2018-11-07" version="1">MPLTRKAAGARGGRRPGSGKAQSTLSFSGRVTKNTVREAKKNITPAAIAKIQPRLQDEDDGVKEEEEEEDDDDDDDDDEGDSQLSQHAEEAATHEPFVPDRTEAEVRAENVNHAQIASYWKEVELQRKAPRVHQQDVDMCEKVLRYFDVSSQYGPCIGISRRKRWLRAHRLGLDPPIEVLAVLVRDEAKGCGARETAKIDGILNSIAVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJN5</accession>
    <name>A0A367LJN5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GPI anchored serine-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJN5"/>
    <dbReference type="STRING" id="1330021.A0A367LJN5"/>
    <dbReference type="OrthoDB" id="3565477at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="361" mass="35762" checksum="C928A2B30F2DFF26" modified="2018-11-07" version="1">MRFSTVAAMAGSALASDYPLPQVSNKVSPQVSSQQVADQISTAYTTNLVTVTACPDSVTNCPVKSMTSAVVTSIEAVPMTTSTVYATKVHTITSCGPTVTNCPAHSTVMSTETIAVSTTVCPVVPNNSGSPAAPGYPGPAPGYSAPPAPGYSAPPAPQYPGSASSVPMPESSAPAPPVYPPVPVSSAPESPESSAPVVSVPAGPESSVEAPVPSNAYNTVPIMISSIAPQISESTVPQQPGPEVSQPAVACPSSSVSAMTKSYTTVLTTVEYATVPVPCGGETSAPIGTGSVPTMVPPMASPPVYPPTQGGNYPPVQGGSNGTVPQPNQPGAEKPPVTAGASSLTIPVVAAVAGVMAVILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJP1</accession>
    <name>A0A367LJP1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_6387</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJP1"/>
    <dbReference type="STRING" id="1330021.A0A367LJP1"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000670">
        <property type="entry name" value="Serine/threonin protein kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055481">
        <property type="entry name" value="DUF7053"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23155">
        <property type="entry name" value="DUF7053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="226"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="580"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="737"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="852"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="968"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="894"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="936"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI14648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="989" mass="108555" checksum="1833A37E0EBB9603" modified="2018-11-07" version="1">MFNKCSKLSTAIPHGIEPDKMVKLLQDHDAFMQCQPYTFKYEFDETPTGPKPTIPERCRVKAIGAATQYWVTDKVPGIPTWIWDADVVSTYELINIEKGLFGRIHFPLNVVLEAVWEVRETGNGEVKLVSDIVIKGSRVLLRVCRGLCENGRKRVHVNLTEKRIQSRWLLTTRHTSAPAAAAIMAALNVRWPELSSTKQRALEDAKTMQKAVIEDCNRAGKEVPQYQLSELIGKGSFGRVYKATSQKTGRLVAIKIIDIEESDTANPKLADTYSDLLKEISALQMLSDSGAKNINHVIEALPVGHSMWMITEYCAGGSVATLMKPTAPGGLQEKWIIPILREVAEAMRWVHSQGIIHRDLKCANVLVTEVGDVQLCDFGVAGVVESKFDKRTTVIGTPHWMAPELFDQAASYGTEVDIWAFGAMVFEIASGLPPNVADGIVDFSQLGSHLKHQTPRLEGDQYSAGLKDLVAFCLQQDASKRPSIEHVQQHGYLFNTDEAYPTSSLAHLVRGFKLWEAQGGDRRSLFFAGGAQARVDVPSTAIASDEWNFSTTAAFDQQVFDSGKAQEVYDAYGSGVDFSQNKFDETSRPSKPKSRRRPPPQLPSVKAPLEKVFDPNTISNYEDNSRAYYGRNFPAPSSDLPLRDESAPAADVRESLIDLDASLHGSHLSQFVDLNTIRAGDSRVSACDFGDAPLYVKAPLSDPADVNVNRRTQDWKFPTMAPPASANPDMFRFPFNDDNAATPEAGRHPISHHPSDSLQASSVFSDVSSKHASTGSLIDLDMSFPDSSTDYTRPSTSHSDVGSISGSEIGGANPFELEKHASLYEMPSTIREPSIYVPDDSRYATAVVDLQSQFPDAQPQPINGGRPYDLGDFADMDPDVMPTPQTAAPLVTRSGPSPQGQYHHQQPTPQGQMPEPEPFNYASLPPLPVAPSSRAMEGRASSEEVKSELRRMAMSLGDHLSHANWLLSNLPATGPSMKLDPVRNEGIGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJS4</accession>
    <name>A0A367LJS4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pumilio homology domain family member 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_6431</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PUF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJS4"/>
    <dbReference type="STRING" id="1330021.A0A367LJS4"/>
    <dbReference type="OrthoDB" id="668540at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07920">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000004">
        <property type="entry name" value="Pumilio homolog 1 isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033712">
        <property type="entry name" value="Pumilio_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537:SF12">
        <property type="entry name" value="MATERNAL PROTEIN PUMILIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12537">
        <property type="entry name" value="RNA BINDING PROTEIN PUMILIO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00806">
        <property type="entry name" value="PUF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUM-HD" evidence="10">
        <location>
            <begin position="414"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="8">
        <location>
            <begin position="436"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="8">
        <location>
            <begin position="472"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="8">
        <location>
            <begin position="508"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="8">
        <location>
            <begin position="544"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="8">
        <location>
            <begin position="580"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="8">
        <location>
            <begin position="616"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="8">
        <location>
            <begin position="652"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="8">
        <location>
            <begin position="695"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="149"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="762"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="175"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="227"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="250"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="284"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="762"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="789"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="805"/>
            <end position="816"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00060736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00081811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI14674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="837" mass="90881" checksum="566607ABE22D5F07" modified="2018-11-07" version="1">MATTTRSRGFPNITMPTGSGEKAQQPLGSAFPGNLYPNQSIWHSSYPTSREKPIGSKESDGSPSGSSALNANSEADPWSSGSNNPWNHPDHPGRSVSTSPSRPRDAVAPAVAPGYFDHQPAVGMSKNSFGPFIPQARTDYIDTINAFSHHRDASLPPSRQSETSPYSDYYRAGHTPSNSMQSQRPLPNTSISSQSVNQRAFNQNKQLDDDLSGQFGRRLGFGAPSSVPATSYGQPFQFNPGSQPWYGPSADQQPSDPVAAQYTNLKRSPVERISPGSSYRLESGSGSRASYTSPSDSWPGKPPARDVDYDRRAAAAAAATASSLAQLPLQPPPPPTSMSNYHPSYFPGQFPYGSMPAQYAAGGGFLDPYNHGLRHHPMMASYGLPAVHAGYPLSTAANLPPVRPSRDQDSGKGMRSALLDEFRLSNKSSKRYELKDIYSHVVEFSGDQHGSRFIQQKLESANSDEKEQVFREIEPNAIQLMKDVFGNYVVQKFFEHGNQVQKRVLAEKMKGKVVDLSVQVYACRVVQKALEHVLVEQQAELTKELEPDVLRVTRDQNGNHVVQKIIELVPRQYIDFIVGALRGQVTGLASHMYGCRVIQRVLEHGTDADKRDIMAELHGSAQILITDQYGNYVAQHVIQNGKLEDRQRMIELVMAQLLTLSKHKFASNVVEKCIEYGTAEQRTAIRKQFTAAAGDGVSPLQQMIRDQYGNYVIQKLLGQLSEPERDTLVEDIKPQFFALKKNGATRQLQALEKLLGLGAGANAKGEVSSSSSSSSSSSSSSSSSSSSSHGHASSATATPVLTHETNTPQSSSPPSTDAIPCASATGGRPAWGQDETA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJY4</accession>
    <name>A0A367LJY4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ran-GTPase activating protein 1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_6899</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJY4"/>
    <dbReference type="STRING" id="1330021.A0A367LJY4"/>
    <dbReference type="OrthoDB" id="184583at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00116">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027038">
        <property type="entry name" value="RanGap"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24113:SF12">
        <property type="entry name" value="RAN GTPASE-ACTIVATING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00368">
        <property type="entry name" value="LRR_RI"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="353"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="358"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI14687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="427" mass="46752" checksum="B6C2BE46998881B3" modified="2018-11-07" version="1">MADLETIFTIEGKGLKLDTAADLEPHIGKLRARDVEEVRLLGNTLGVEACKVLGEILATKKNLKIANLADIFTGRLLSEIPDALSSLLTSILNLPHLHTVNLNDNAFGLNTQAPLVAFLASHVPLQHLYLNNNGLGPHAGILIADALSELHASKEAARKDGKEVPDLKTIICGRNRLENGSMTAWAKTFSLHNKIQEVKMVQNGIRQEGISHLLTRGLNHASDLKVLDLQDNTFTLMGAKALAKVTPTWSLLSELGIGDSLLGARGGVLLSEALAKGKNQKLEILRLQYNDITAAGLRGFATAAKDALPALKRIELNGNKFSEEDDSIRALQELLDERKEALGGDVIIEADWGVDSLSDLEEEDSEEEEEEEEEEEEEEEEEEEDVEPEKRAEKLIQEAEEAQEEPVVQIKDAEVDDLAKKLAKTDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LK05</accession>
    <name>A0A367LK05_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 11">Cystathionine beta-synthase</fullName>
            <ecNumber evidence="4 11">4.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_6688</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>L-homocysteine + L-serine = L,L-cystathionine + H2O</text>
            <dbReference type="Rhea" id="RHEA:10112"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="4.2.1.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.22" evidence="4 11"/>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LK05"/>
    <dbReference type="STRING" id="1330021.A0A367LK05"/>
    <dbReference type="OrthoDB" id="728at2759"/>
    <dbReference type="UniPathway" id="UPA00136">
        <property type="reaction ID" value="UER00201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004122">
        <property type="term" value="F:cystathionine beta-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019343">
        <property type="term" value="P:cysteine biosynthetic process via cystathionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04608">
        <property type="entry name" value="CBS_pair_CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000003">
        <property type="entry name" value="Cystathionine beta-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000118">
        <property type="entry name" value="Related to CYS4-cystathionine beta-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046353">
        <property type="entry name" value="CBS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005857">
        <property type="entry name" value="Cysta_beta_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01137">
        <property type="entry name" value="cysta_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 10 11" id="KW-0129">CBS domain</keyword>
    <keyword evidence="11" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="12">
        <location>
            <begin position="369"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI14751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="512" mass="54849" checksum="D33CB7CF0BC6F3C4" modified="2018-11-07" version="1">MATSTLPFVGRKPATVLSATDLIGNSPLVRLNRVPQSLGVECQVYVKAELFNAGGSVKDRIALRMIQEAERSGRIKPGDTLIEPTSGNTGIGLALVGAIKGYKTIITLPEKMSAEKVAVLRALGATIIRTPSQAAWDSPESHIGVARRLEKEIPNAHILDQYGNKDNPLAHELGTAEEIWEQTGGRVDVVVAGAGTGGTITGLARGLRKHSRDVKIVAADPEGSILALPDSLNEQHANEPYKVEGIGYDFVPDVLDRELVDRWYKTDDRESFLLARRLIAEEGLLVGGSSGSAMAAMLRAVKDLNLGRGHVVVVVLPDSIRSYLSKFADDDWLAANGLLPAAEGADIAVNGASTASADPYHGATVGSLRLKPVISVEATASCSEAIETMRDKGFDQLPVLSSSRLVGLVTLGNLLSYISRGRATGQSPVRDVMFDFAHLDEVVTDPRRGAASRRRKFVEITTDTPLSELSNFFEWNSAAVVTEKSSDAKALSKPVAVVTKVDLLTWMVSRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKV0</accession>
    <name>A0A367LKV0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7113</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKV0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI15041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="95" mass="10297" checksum="7AAB8E94065CBD58" modified="2018-11-07" version="1" fragment="single">PKARHNALSHSGAIARSLQRSARCTYSGYSTRLISAQGSRHIDRRAVLIAVIALDQSDRRAVPIAVIAPDLDGQIMPNTEKITFAKLSGGDNYTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LL29</accession>
    <name>A0A367LL29_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_7008</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LL29"/>
    <dbReference type="STRING" id="1330021.A0A367LL29"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF54">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="5">
        <location>
            <begin position="57"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI14962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="508" mass="55274" checksum="95D7D0BA8A32F2E7" modified="2018-11-07" version="1">MKHGYVIAAAGLASSVDGHRTASLCCNRLSHHVPSLYQDPSSARYEQLINARWSNNSILHPACVVTPKSADDVSRTIRLLAAYRCDFSVKGGGHNANPGANSIDDGVSIDLASLDSAYLASDRSYVSLGAGISYGKAYDLFNDTNVGFVGGLHDGISAGGLSLGGGTSLFQASRGWAVDNILNYEVVLSCGTIVNANQKSNADLFKALKGGNTNFGIVTRVDFKTFEFKGLWDAEVVVSLKGPQVGRSEMLDKISRTMVDFVANNDKDVATSIHVAVTYVAAMQAELAILAITNSDNVENPALGRPARAVPNQRANVARHGKVANYVHAISRFQTKGSRQVTATLTISNDYDTLREIWDASDMVYDELPQKVGVQWIVQIFAQPKIQQSYSMKHGGNSLGLANVKDDQLVIWLTARWNNTSFDGMMDKAQKRFVQATEAVARKHGTLSPFLYINFAGYFQNPLCGYGPESVAHLRKVARKYDARRVFQHLMKGGFKISQADCGGRYER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LL64</accession>
    <name>A0A367LL64_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="12">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">L249_6880</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="12"/>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LL64"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17920">
        <property type="entry name" value="DEXHc_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18794">
        <property type="entry name" value="SF2_C_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001975">
        <property type="entry name" value="ATP-dependent DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000537">
        <property type="entry name" value="Bloom syndrome RecQ-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018982">
        <property type="entry name" value="RQC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF153">
        <property type="entry name" value="RECQ-LIKE DNA HELICASE BLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09382">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00956">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="13">
        <location>
            <begin position="916"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="13">
        <location>
            <begin position="950"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="13">
        <location>
            <begin position="983"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="13">
        <location>
            <begin position="1092"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="13">
        <location>
            <begin position="1124"/>
            <end position="1156"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="13">
        <location>
            <begin position="1189"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="13">
        <location>
            <begin position="1225"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="2105"/>
            <end position="2286"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="2317"/>
            <end position="2458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1306"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1514"/>
            <end position="1718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1896"/>
            <end position="1925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1969"/>
            <end position="2010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="2027"/>
            <end position="2070"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="2614"/>
            <end position="2674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="2697"/>
            <end position="2727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="2846"/>
            <end position="2900"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1813"/>
            <end position="1840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1309"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1532"/>
            <end position="1543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1627"/>
            <end position="1636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1655"/>
            <end position="1672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1704"/>
            <end position="1717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="1977"/>
            <end position="1986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="2053"/>
            <end position="2068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="2618"/>
            <end position="2630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="2847"/>
            <end position="2864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="2880"/>
            <end position="2900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RCI15173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="2900" mass="320106" checksum="5652D4FCD3A4684E" modified="2018-11-07" version="1">MALSDAFKLSLVAAITILIYHWLSSRGKRPGQATSTEKHLTCRIRGVPVDWDTSQLQGFLEEHVSVAPPVVKSLALEIDGRSRTGTATCPGKYPQRIRQAKLSIHLSLDQDFLGITTLYAPPLDDHRIDVIAVSGLGGHAFGSFKARNDDYMWLRDSLPGELINQDSELPMARIMVYGHESRLAKSISMQDLEDMSVSFRESLLPLITDTTTPRPIILMGHSLGGLIVKQALASITASSSYERLAQAIHGIVFFGVPHDGMDINGLRKMVGNQANRFLVESLSDKNSSVLTSLRRDFNKLLDTLPDVQIFSFFETEMSNTLKQSGKWTMDGDKVFLVNKTSAIHCRASEYDSLHICPIHSSHVELVKFGRHDNEYSKSLAFPQMIERYNDIDDASSGTCKWLLEHDHYRNWKHTDRQLLWIKGKPGSGKSTLVRYVLDHIQSDPIARNRSLFISFFFHGRGTALQKTPLGFYRSIVHQLLCQMPTALPDLIASFQQRQKTVGEPGSEWEWPAKELQEFFRKNLSAVLKHRAIWLFVDALDESGKENAVNLFQFFKSLLQGISSTGGLFHICFSCRHYPILPGDHGVEVCLEDQNADDISTYVQAQLSKSRLLAESTVPAMITERASGIFLWARLVTQSALTLESDGHSITKIERSIESTPVELDEVYQDLVRSMMDDRKYCLKLFQWICFAIRPLSLDEMRWALAIDVDGLHHALERYRSMDEHISTNEQMEKRLKSLSRGLAEVVESPTGHIIRLIHQSTQDYFVHKGLLSLQVGNNNNSYNAAGNSHHRLARSCLRYLAMEEICRLEDETLPDRAILTEQFPLLRYSTVYWPIHVQASEVENVPQEDILTYLSWPSEKLVQLWLRIYRVFDKDVLPEGYQTLHLLADYGLAGPLKAVLENHDAINIHIDARDSLDQTPLLWAVNTFERDAVVELLLENGADINARNSEGETALSLAAYHGHTSIAKLLLKKGAAASTKQNNGNTALMEAVKRGHLDLVRLLLATEGVDPDSRNDRGDSPLLYAAAYCQRSPFVPEYAVHSFLYNELDLRQRSSQGTGMLWNSTHQKQDLHICIAELLLEKAVDVNAKNRIHDTPLLNAIRNGNEAMVEFLIQHDADVRSQKHRGLPLEEALTYGSEAMVKRLFEKGADLNMDKTDIAGLFRAAVTRENENFVKLLLDNGFDVNATCYGHTPLFSATASGAVAIIKLLLAAGADVNSRGASYVKHRTPLLQAAKMGDEITVKLLLDHGAIFDPGDDDTQAALSRLAANGRDNMIHSAAGFMTRNNLAEHLTWLMSNVSSTKPAVQTFPASGAHAPSQPPQSQTSTASAPRSRAANSTNRGNICDSDPRGDGLTASRENTAGARSMGRLTSTTKSKKPLLVSQQLPTPCATGDERATQQQRAGLAAQDAGRASTARSRLPASDKKPFRPISSPMTKLDFTDFDDDDLEVMDLTEDANASVGSLEFGDDVKLWDDKTAHWSSPAPSRSAKKRKKCVDGMSNGLADLEDEFPDVYQILGTNPPASTPRLKSAPGHHASAVGSSRSRAGEGTARDVSGKRAKRDAVAALSQVAEEEVSSPSRRVTERRDQLAKSQASGKHPGPPASQEFRKRRRVSLEPSTFSLSSGDEAASRQIEKDGKKKKNDCVPDSEDEFLTPPSCSANPEFANTVSSGKSTRPRSARQMCGDKGSAEASTHGGGIANLGSGVVNSTHSSPPSSQAPKLLTLLSANPQALSHRLASLESQIQQNGRAFSRAVNERWSKEKRNAVKAEKERLLKQQSAVAGLIDSMDSYRAICERRESLANEVAESYANGLDTDEDEIQLDELTDQVQEMEQQLVPLLSDAGLDKTSFSELMTDTRTGSAAAVVLGTQPSHGGTMNAPADSDQPSLIVASETQVVQQTQFPGTSRCRPRNEATAATSRDDTTPLDEEDFWDDVVSKELNQFKASQASKDKAVARQTTSLEEHEDLFSDMEDNGLAPFPTPRRPPAQPKSTCTAPPRGRAHAGGGGDNFSDFSDDADMLAFAQDYETRQSGKGATPGRSRQVLSPASGNKLVPANNTLSKRPPASSSAGLSIPPELMRHPWSPEVQKILKDRFRMRGFRHNQLEAINATLGGEDAFVLMPTGGGKSLCYQLPAVVKTGKTRGVTIVISPLLSLMQDQVEHMKALGIQAVAFNGECSTEYKRQVMSAFDERSPEHFVEILYVTPEMVCKSTLFTKAMQNLYRRGKFARLVIDEAHCVSQWGHDFRPDYKTLGQLRLQFPEVPVMALTATATQNVIVDIRHNLGMTSCQIFSQSFNRPNLYYEVQHKKSNADATEKIAKLINTKYRNVTGIVYTISRKQAETVAERLREEGIAARHYHAAVDAPEKARVLSAWQKGPVKVVVATIAFGMGIDKPDVRFVMHHGLPKSLEGYYQETGRAGRDGKPSDCILFFGKADIRVLKKLIADGEGSLEQRERQMVMLNRVTSFCDNMSDCRRTEVLRYFGEDFVPGQCQKSCDNCRSGLVFEQQDFSTYATAAIRVVQKQRRLTPNQCADILLGKQYPDKELELSDEYFGTAKGLKKHELIRVIDRLSAEKAFNEDNVVGNHGMAIQYLQIGPTARLFLTGQRKLMLTIQVSEEPKAKAKSKTTRGKAKKAARESPPVQSTYVSSPMMDRRHSRTMQWGSGDDDEDGLPTTSNGYANDGFVVSDEEMLEADDDEAFEPLPKHRPARPAARSVVGSGNNNNNNNSTLGPQITVDERLGSLSEIHQDLVNAFVLEAQKVEERIRNAKELRRPLFTERDFREMAMNWTTSLDKMSRIPGIDVQKILAAGGGGGGGGGADEDVVDLISSEMEADDDDVEDAFHNRLQGLESQQASSGQGRSSNNKSSYRGGGGRKFSGKRWQKRGGGNGSLVKKSGGGIGLMPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLE5</accession>
    <name>A0A367LLE5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6697</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLE5"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="67" mass="7247" checksum="257E625B92709078" modified="2018-11-07" version="1" fragment="single">RNAHTEANCIAEEGTPCLTCSLTYPTFLPSYGPYGPYGPASYVVVLFLPLLCNVRRPRVGCSRPGVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLG6</accession>
    <name>A0A367LLG6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">M-phase inducer phosphatase</fullName>
            <ecNumber evidence="2 10">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_6900</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the MPI phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2 10"/>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLG6"/>
    <dbReference type="STRING" id="1330021.A0A367LLG6"/>
    <dbReference type="OrthoDB" id="26523at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110032">
        <property type="term" value="P:positive regulation of G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01530">
        <property type="entry name" value="Cdc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000021">
        <property type="entry name" value="M-phase inducer phosphatase cdc-25.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000751">
        <property type="entry name" value="MPI_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF17">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00716">
        <property type="entry name" value="MPIPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6 10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="12">
        <location>
            <begin position="373"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="239"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="517"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="251"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI15276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="559" mass="62244" checksum="704249E6D38A2C1E" modified="2018-11-07" version="1">MEASSPLAALHRPMMPAPSWGGRDVFRSGPHPRYSSALREQLHKCGGPDYFNFKEVRGSSPAASLAADLSQNFRLDNDASPQFPTPRRALFTANMMSGMETRHMVTTPPLPSSSPGPTMELMEVSPLPHKTPFTTTHVIMASPAADVDEEEDEQAYDEDEDDGDNMVLDSPAPIEPSKPFVADRRIAAPRRPSLSRIKCLTTTAVPARSQPEAQPPTFRFGSEHGLSHASSSVSLSECFETASPPLDPRPQSANSPCPSVSMASRPRPLFASTAGSRHGSSLNCHIRRQSNPFLRNRKQFRRSLSMFETPADIMKPKPDGDEPASSSLKSVMDIEEIHEPRLPHFLPDDPSDTIPRVSKETLLDILDGKYAEQFDQKMIIDCRFEYEYDGGHIQGAVNHNDKELLATQLFHTPMSGRTLLIFHCEYSAHRAPLMARHIRSQDRTVNAEDYPRLTYPEVYILEGGYSGFFADHRSRCFPQEYVEMSDEKHQRTCEREMGRLKARKGLGRAQTFAFGQRESCINDSPTGPSRPGSRLASISTLGDSPPLSERSLTRRMASY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNK4</accession>
    <name>A0A367LNK4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thiamine-binding protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_2192</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0045 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNK4"/>
    <dbReference type="OrthoDB" id="5587367at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029756">
        <property type="entry name" value="MTH1187/YkoF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002767">
        <property type="entry name" value="Thiamine_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051614">
        <property type="entry name" value="UPF0045_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00106">
        <property type="entry name" value="MTH1187 family thiamine-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33777">
        <property type="entry name" value="UPF0045 PROTEIN ECM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33777:SF1">
        <property type="entry name" value="UPF0045 PROTEIN ECM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01910">
        <property type="entry name" value="Thiamine_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89957">
        <property type="entry name" value="MTH1187/YkoF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thiamine-binding protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI15971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="136" mass="14748" checksum="2DA05BB8D6A1914D" modified="2018-11-07" version="1">MDHDNYNSIPLPARCYADFCLVPIGTGNASVADEVAAVQRLLKKSGLSYTMHAAGTTVGSWDQVMTVIGKAHTIVHQRGVVRVQSSIRAGSRFVIFSASLGTLILTDGIMSRTDKSQTAGEKVERVERLLQAEEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNW4</accession>
    <name>A0A367LNW4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_3064</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNW4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI16071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="102" mass="11120" checksum="6A19023743F5C522" modified="2018-11-07" version="1" fragment="single">CRFCAFASRLDGQSITAPSSAPVPIAITVSITPLISFTSTGLKQSGLRFPIFPPYSPYSPPPIKYPHPLPLQLMKPLVKNECLSLSHLPRRNIFTKADLLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPL0</accession>
    <name>A0A367LPL0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histidine acid phosphatase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_3224</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPL0"/>
    <dbReference type="STRING" id="1330021.A0A367LPL0"/>
    <dbReference type="OrthoDB" id="258392at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF127">
        <property type="entry name" value="HISTIDINE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017016737" description="Histidine acid phosphatase" evidence="2">
        <location>
            <begin position="20"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="437"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI16384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="557" mass="59414" checksum="C845DC56EA772452" modified="2018-11-07" version="1">MALITIFVVALTMAVRVTADTVWAAAAYITHGETSPLLAGSQHVLTPDGAQQMWRQGSAFRRRYLSASNGTSLRNMPVDTIDNRQLAVASRNKAWVFGGALAFLQGLYPPHTTGLGRNYAAGNAAVEYPLSGYQYPLVQTLSSQDPSSVGIQGDVGCLAWQQEIETSFLTRKDVIPRTVASDGVYKELFTTQPLQGIIPLEQANYANAMEVYNLVKYLYTHNETVNKNLEKADSVIRILGYLAFSSERYKTGYNGSAPMPLAEASSAGLYSIAGRTLATQLARRLASAVGVGGARGKMTLMFGSPRPLISLFSVLNLITRETLGSGPLSRMPGPGAALVFEVVSDAAAGAGRSFPRTTDLRVRLSYKPSADANEDFTTYPLFGSGLDGAAIPYTAFLRQMTGRGATVTQWCRVCHADLTSPWCSSGSAVARSGLNSALVGVISAALLLFVVAFIAVVFCLRKGSARWDGKKLSFGALGGFRRWQKGPCDADVSVSRIGAAEARIGSWELRQGAGGASSGAHTAGIVNRNFSTPSTFREYDDDGVSLTGLPVKPRETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPL1</accession>
    <name>A0A367LPL1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_2847</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPL1"/>
    <dbReference type="STRING" id="1330021.A0A367LPL1"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016703164" evidence="2">
        <location>
            <begin position="17"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI16349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="156" mass="17324" checksum="71C7C50DEBACA5A4" modified="2018-11-07" version="1">MKFISVATLFLATALAVPTGDTDKRDVYRPPPQNTYPPPPPPPKKEYPPPHPPKKPPPPPVKPPKKEYPPPQPPKKPPPPPVKPPKKEYPPPQPPKKPPPPPVKPPPKKEYPPPQPPYKPTPPPVKPPPPPPKKEYPPPQPPKNEYPPPPKYGYPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPW5</accession>
    <name>A0A367LPW5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM complex subunit LSM3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LSM3</name>
        <name evidence="11" type="ORF">L249_2476</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPW5"/>
    <dbReference type="STRING" id="1330021.A0A367LPW5"/>
    <dbReference type="OrthoDB" id="29543at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01730">
        <property type="entry name" value="LSm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000036">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034105">
        <property type="entry name" value="Lsm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040002">
        <property type="entry name" value="Sm-like_LSM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13110">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="13"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI16449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="100" mass="11117" checksum="159BBE4D20C8FC4F" modified="2018-11-07" version="1">MADAGEDSGHVAEPLDLVRLLLNEAVFVKLRGDRELKGKLHAYDSHCNLVLGEVEETIYAVDDDDETSNDNEDIKTISRKSEMLFVRGDSVVLISPQTPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPY5</accession>
    <name>A0A367LPY5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_2398</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPY5"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI16302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="300" mass="33869" checksum="EB9E923584C01032" modified="2018-11-07" version="1">MSWLDYVEQAENQMVMGIKTRRDETEGTMMTMGYERSNSPSSKKVDQKHVKTPLFNKSQDDLSPGLGLYFLLSCFLIASNMKKRNRPRIGHDRLRRPVHRLDGAPPPQQPHGQPRHLVERIPGAHVEAQVRRGDGAVEVPDLRPQPGPGALPLEQGVGLLLRRRVGEGVAAEHLVDADGLHQEHQRRQRLRVARQPARLRQYLLDEREHALPDGRMEPLARHAAPEALRVKGHDEGHQALDPEHAPELDHGLRRLAARRLESFEGVGPLVLQVLTPLEQMHLLVAEHRHVSFEPRVLAVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQB4</accession>
    <name>A0A367LQB4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_2924</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQB4"/>
    <dbReference type="OrthoDB" id="5144659at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000515">
        <property type="entry name" value="MetI-like"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50928">
        <property type="entry name" value="ABC_TM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="6">
        <location>
            <begin position="164"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI16577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="258" mass="27509" checksum="ABCBECB0334F8F52" modified="2018-11-07" version="1">MVFFCRRAPSFSETLNWFFYPVLLRAMNIPASALLLVAARFAAAGIVNWPLDDAIQFVMKMGDDCIYGEVTPSGCGLLLRLGCCLLRLGSCLLLPTSLLPTSLLLLPPTLLLLLPSLLLVDLCLLRLLLPGLGLLLLLPGLRNLLLLLLLLLLLLLLLLLPAVLLAVLLAVLLAVLLAVLLAVLLAVLLAVLLAVLLAVLLAVLLAVLPAVLLTVLLAVLPAVLLAVLLAAAPQLTLPTENLWQSSPPPRWATGMLMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQQ8</accession>
    <name>A0A367LQQ8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_3016</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQQ8"/>
    <dbReference type="OrthoDB" id="15595at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018852">
        <property type="entry name" value="DUF2456"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28297">
        <property type="entry name" value="FUNGAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28297:SF1">
        <property type="entry name" value="FUNGAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10445">
        <property type="entry name" value="DUF2456"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI16758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="329" mass="36975" checksum="12772E378D072600" modified="2018-11-07" version="1">MLREKAPSLPPRHNDDRQTVDDDGINAHDEEAAIVVHRRLEPSRKLTAHQFFYMFVLDGLGGLVLSGGINFGIAYAMYSRANPEKNPVRLFQLANTLAGDGVVTIFVQCLITWFIETTLVAYDVEHGSVQTIGWIAEPNNSLLRSFFLLAKDPQLGTPPMRFRAGVMPLIRLVVRGLVFAVASFFLFWPISVGILAGVGHRHADGDYYFDNVWAPQVYKLLLGGILGLVTGPLMAMYWLARYGWESQTAFRRAHEAAARYAVEEELARAREVDQSPNQVETEDVEEETNKKKKKKKKKEKKKQKNKVDKISSIRDAEVVAAERASEQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQY4</accession>
    <name>A0A367LQY4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_2706</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Required to prevent the proteolysis of the CreB deubiquitinating enzyme in the absence of carbon catabolite repression. CreB deubiquitinating enzyme stabilized in a complex with the CreC leads to the expression of genes such as those in the proline and quinate pathways.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts with creB.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat creC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQY4"/>
    <dbReference type="STRING" id="1330021.A0A367LQY4"/>
    <dbReference type="OrthoDB" id="3367at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045013">
        <property type="term" value="P:carbon catabolite repression of transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051362">
        <property type="entry name" value="WD_repeat_creC_regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107:SF16">
        <property type="entry name" value="AT02583P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107">
        <property type="entry name" value="WD REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="422"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="108"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI16829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="608" mass="67019" checksum="9E3955E35E1B1273" modified="2018-11-07" version="1">MFVLPPPPRYPSGGPYHSSGLTGIVPMIETNNTLSNPTGPEWQFLEDLHLATPPPHPSEAPIVNPNPLATNRQPATVGTKISLVSLDMRPQPFTYRGPAERTLSLEHFNDTRNSNEGGLSSDDGRAGSNSDGLTASATMGSAPAFGEGNALLAATTSRDANKRKKPKNNVTKSNSSFISRVIVNESLSRRLTDRPADGVFAFANVNRAFQWLDLSSPCKQEYLTKILFTKAHCLCHDVNKTTKSASHMDVIMGFSTGEIIWWEPMSQRYTRLNKNAQGVINSTPVSEIMWIPGSENLFLASHMNGSLVVYDKEKDDSQFNPEEEASSANCSDAGEVPSTRGIRIQIQKSVHSRNQKANPVAAWKLSHQRINAFAFSPDHRHLAVVSEDGTLRIIDYLKEEYVPGLCFARPPADSRPRLLHLFNSYYGGLTCVCWTPDGKYVLTGGQDDLISIWSLADSALVARCQGHQSWVAALAFDPWRCDDRNYRFGSVGEDGRLCLWDFGVGMLHRPKNAARQRASMSLPSGMPLRTDSASLLGARVRSSTGVDDDYDKFHLVEPRARIPMLPPVLTTVIDTHPACWLAFTEDAILTSCKSGHLRTWSRPGRSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRB0</accession>
    <name>A0A367LRB0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRB0"/>
    <dbReference type="STRING" id="1330021.A0A367LRB0"/>
    <dbReference type="OrthoDB" id="5015991at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="54"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="111" mass="13656" checksum="167EA3F88FABA045" modified="2018-11-07" version="1">MCYFEQTRWRCGYWRWGNFREQCPKEYRMGETCGLKLVYETRVEEDVCKICHDMDKKKRRYDKMCRDVQRWEREGNRKATIERTSDDMKVVQAQIGALRQEHNARLQSLHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRJ7</accession>
    <name>A0A367LRJ7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WLM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_3114</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRJ7"/>
    <dbReference type="STRING" id="1330021.A0A367LRJ7"/>
    <dbReference type="OrthoDB" id="49605at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013536">
        <property type="entry name" value="WLM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47795:SF1">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE WSS1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47795">
        <property type="entry name" value="UBIQUITIN AND WLM DOMAIN-CONTAINING METALLOPROTEASE SPCC1442.07C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08325">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51397">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WLM" evidence="2">
        <location>
            <begin position="141"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI17074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="364" mass="40262" checksum="67333570D26DFC50" modified="2018-11-07" version="1">MSLEKQSEKLSLGNGPASSSSFVTITVNHRRRHWNFDFAETATMTDLFEEISSSLDIPLSNQKLLVPKGLLPEAPNGLLLKSSSDTFPSLRDLQGKTLTLLGSGAAEVQAVNSMAEKIASRNATRRAQAGKPRTSRETQAIAALDAKYTFLVVRPLDGLPNPERSTAILMRLKNDPGIRAAMRKHRFSVSLLTEMEPLAHTSASHEGTSRTLGLNRNKGEVIELRLRTDAHDGYRDYKTIRKTLCHELAHNVHGPHDASFWALCHQIEGEVDRADWKTSGQTIGESSRYAIQGRDEEAVEDEGGWTGGEFRLGGATVSMRDSSRRQILAAAALARQLNEVRAEGRAVDDADKDERERRRRDKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRV9</accession>
    <name>A0A367LRV9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_2167</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRV9"/>
    <dbReference type="STRING" id="1330021.A0A367LRV9"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF11">
        <property type="entry name" value="WSC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016776814" description="WSC domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="541"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="641"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="381"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="473"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="643"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="661"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI17183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="679" mass="71630" checksum="3F38F6909F5537B2" modified="2018-11-07" version="1">MKPHLLLSALVMATTTTTTTTEAKNQRTFAVLRFTNKQLTKGRMDPIRSPGKTGAHVHNILGGSGFSLTSDGHHLASSNCSTAKVKGDNSNYWFPSLYFKDPKTGKYEDVELFYANAYYFFEPTNDEIKPFPLGLSIVSGDIDTRSAPAAGAVTNLDASNGPINPVKWTCPRNGNVYDPPSWPAGSDGKLAGIGDPVNKGEGVGFPDVNCDGFASPLRADIHFPACYDPAVGLTDYKKNMVFPSAAADGKMDCPKGHIHVPHLFLEIYWNTPAFKDRWEQGKGSQPFVLSNGDATGFSLHADFMAGWDEKVLQHIIDTCDAGTAGMDKCPGLPYGLNQDDCTIPSAIDEKVDGVLDSLPGSNSIAGWAYGGGGGGGAEVVSSKPAAAQPSSSSAAYEPAPSSSSSVETPRYKLPVNGIIGASTESLPPPAATTTKEAVRYHVPTRGLPKHHYGNSTNSIASEATPSSSLINNPPAASSPAQQPTTTTTTSEACIIKTVTARETVTVTMESSQGPAEKAQVAAVMVNGGRPSFTNSTRSLNGYKYAGCFQDSQQQRALRDVIRADMGVGGGAAECIDYCRAAGHALAGTEYGGACYCGDALVDSSRLDEARCNMACEGGGRGVCRGSWALSVYSRHGQVVVNGTASSSPSSSPTATKGGTYKGRRRHFHDHVRRRLSPHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LS23</accession>
    <name>A0A367LS23_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_2837</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LS23"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI17211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="127" mass="14858" checksum="D071860915853A27" modified="2018-11-07" version="1" fragment="single">CVLRDRSRLKSIVPLLFFPPRIPMSFSVGLILPPIKRSAVSETITNQRQGLEARDKGIKIAHSHSRRHFPSYLCSITAISISYNQQRRSFRRNYPHTGREKEAHVSRRRRRICKPYKCHYLPSFKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LSQ1</accession>
    <name>A0A367LSQ1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LSQ1"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI17438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="126" mass="13837" checksum="AF4D5EBCB0895DE9" modified="2018-11-07" version="1">MPLMMGLTKAASRRTTNSKPSAETRVTYLLISGVCIVSMCRSRCDKRLLFISPSYQYLSQSLSSPPRHSFPSLSSPPSPRPSRRGKKGKDADGKKHPRHPLISSRSLGSIPFHSIPFLSISLLALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LSR0</accession>
    <name>A0A367LSR0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2673</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LSR0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="602"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI17390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="687" mass="75253" checksum="4EA31CAC04F7A713" modified="2018-11-07" version="1">MSPNPPSRTRNPLFYSPSPSPDSPSSIRPSSGPPPPTPLNHAPSSIIVLQPQSIEAKGKKKNPSLLCQVRCTYHLAHGYVERSPHMDIRQQLPVSRALEASWRQAVGASAPVLDHPARANHTLPSSLQRRTYVRDDLHLTLHNSPVTGTFKLVVLLVCCSVNDQYQALIDKEPSSLFTAISSLYQASDRKQTNRTLVYGYPTDLWLNPIGQPHHLVIAGLRNHRGTTVASSRPVVWPSFGSRSRATVTVRLRDAAMELGPQLTRKINVPKLAKMLHSTTSSINRTPMLIPGLSAMYKTTSPGQVPSNEWGLYICQSENIQANGRLDSWQTSRQEDKKTGSTQTHNHITAWQPPRKSTIRLVSGPKTDRPWTGGEGLAGEGYPLSRSMKTGTDKKGAGQPRAETGEGAAIASVEPEKALQDGQSFFFLSFQDEARRSRYDPLRRASVFGNACRSRNRHGEGERMLRLPSSSQYLVVNLGLGFWGKGGSGGGKGWQLAANFFTDMDMDTSIARQKPEPRLLRRGDIGDGYNASHVLGGRAKKLSSRIAPGGKCFRHRPLGGLASFASNGALALGSVVAATWQRVTIEARLRCWPDVMYSVGQGIRHGPSEGHSRVQQPSRKMGDDKRKFIHPDARPREQVAVDRLQCASLASLLQLDGPGIAGHVAANYEPDTDLVSGWMMGRVEYLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LT46</accession>
    <name>A0A367LT46_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peptidase S59 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_3302</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin GLFG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LT46"/>
    <dbReference type="OrthoDB" id="3797628at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034398">
        <property type="term" value="P:telomere tethering at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1610.10:FF:000003">
        <property type="entry name" value="Nucleoporin SONB, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1610.10">
        <property type="entry name" value="Peptidase S59, nucleoporin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025574">
        <property type="entry name" value="Nucleoporin_FG_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037665">
        <property type="entry name" value="Nucleoporin_S59-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007230">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036903">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021967">
        <property type="entry name" value="Nup98_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP98-NUP96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198">
        <property type="entry name" value="NUCLEOPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04096">
        <property type="entry name" value="Nucleoporin2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13634">
        <property type="entry name" value="Nucleoporin_FG"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12110">
        <property type="entry name" value="Nup96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82215">
        <property type="entry name" value="C-terminal autoproteolytic domain of nucleoporin nup98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51434">
        <property type="entry name" value="NUP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase S59" evidence="12">
        <location>
            <begin position="892"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="19"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="359"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="533"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="592"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="707"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="787"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="872"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1067"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1132"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1213"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="368"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="400"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="445"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="472"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="546"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="592"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="717"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="833"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1132"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1218"/>
            <end position="1227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI17480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1963" mass="206189" checksum="917FE0D30E5301C5" modified="2018-11-07" version="1">MSFGSSGFGGFGSNNNQTSSAFGGGGFGANNNNSGFGSTNTGGGFGQNANPGSGVFGGNSNPSGFGSPSGGFGSSAGGGFGSKPAFGSGNTTGGGLFGASNTNNASNTSGFGGFGTANNANSSPFGGGNASGGGLFGNNANKTGFGAAANTGTSLFGAANTTSGGGFGASGFGATNNAGAAVGDPPGTAATPFSAFTEKEPNSTNQSNSFQNILFQDPYRKWSAEELRLADYVQGRRHGNASGAGAFGVNSGFGGGFGSNNQTTSAFGSSSNTGGGLFGASNPNASSGFGQAATGAFGANNANASGGLFGNNNKPSGGLFGNTANQQSGGLFGSGTGGGGFGANSANSAFGGNSSNTGGGGLFGSNNQANKPQGTGFSFGNTNANTTPSAFGSNTGGAFGSSSTGNSGLFGGSNNQQSGGGLFGNNLQQQQPNTNSPFGSGFGGQNQNQTQQSGGLFGNNQQKPASGGLFGSTATNTTPSGGLFGNANNQQQGTGAFGTNTNASTTGGLFGAPKPTTTTSLFGATNGNQANTTSTGLFGGLGSNNQTQAATGSSLFGSTNNAQQKPGGLFGAANPTSNTGIFGGVNSQNQGGSLFGSSANQQQTQGSVFGGSLLGSTQPTGNLPQGLTANLNDVSAYGSPSLFSGLSGGEVSNPGPLATPLNGSSKPRRSSILPLYKLAPSAASRLGTPQKRGFGFSYSSFGTPGASPAGSISSTPGALGRSLLGHGSSGTLSKSMSTNNLRRSFNTEDSILAPGAFSSSSNSRWYGSSGAKKLVINRDIRSDLFSTPQRDKHSIDGSASARKLSKRVSFDTSNVEAEDGTPLRNALPPPEGTPNSQIDDSTPRQNRALAAANGNKTPEMEQVKGNELAVVHEEDHTATPESPNTPGRDQAPGKYWTTPNKDALLNMKRMQRQRIPSFTVGREHVGSITFKVPVDISGIDVDDFCGTVVVLEPRSATVYPNQAKKPPVGRGLNVPAIITLEQSWPRGGREKRGSNDVKRINRHIERLRQIPDTTFESYDEETGTWVFSVEHFTTYALKDSDYDSDEDDDENPRVMETVLTADSPAVPQDLVDNETKGGESVGSARGMGVPGAFDCEQELPEAADEQHFLGDSSADLASNSVLLSVDECDSNMDDGYDVSEDEDTTRSSIGQHRAAEQDGTSSEIDQEPKRGTPGGILRARMRAMKESIGPVRLEVADGDDWMSMLMKTVSPVKRNRQQLREQNESPSKRQRTGDLINLDGDAGLLAMSSIFARSPSKVDQAPTTGNRGFSTSIDLMNSLFQKSKSSSTAVAALPKKGFPEWPYDRQEKSSTIGEAEQAYHNASRPTWGPGEALVVTRSLYTAQTSRTLRGVMSFQRSGIRTEQQDVRLAKFSTAVWCPPMHDRAGTRLLTLSQPSRRFLQAQSDLTEISVVDGVPMASLRATNLRDLFHQQDIQDPANIHEGQVWELASILFNRLSPRDSADGENLARRSKLSQFWTDLVEAASTTNIGLASCSEERVVACVAGHRIEEACKYLLEGKNYRLGTLVPLMGTSDEAKKEMREQLKAWHDSKMLSEFSDATRTIYELLGGNACVCEGMKGVPVEDRMDSFVISRKFGLDWRQSFGLRLWYATNEGDGAAAAVRMFEEDLDQDREDPPRPWFIEQGFLPLWDDPGAEKRQDLLWGLLRLYADKDADLEAVLRPENSQLSPMDMRLSWQLGVALISTGKVSFGQDGVEKADASTLSYATQLTAAGEWLEAIYVLLHMHDAKARARAIQEHLCRNGGLIGSGSETNFSMLVDKFRIPAKWVWEARALYMRGVERDASAEVHCLLQAESFAEAHRVLVQQVAPRAIIERDYDTLSALVVQMEHQRDSIPGWAMGGQVYSSFLTMMHQREHGESVATAMLDKLHGSLSAMSASVSDDDVVGFAAISDMADETAREIARWGKGSQAMEARSRIMGLPLTQDRLLAYSVDLGIDCYREVMSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KYY2</accession>
    <name>A0A367KYY2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_3346</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-10" db="EMBL/GenBank/DDBJ databases">
            <title>A genome scan of diversifying selection in the zombie-ant fungus Ophiocordyceps unilateralis complex supports a role of enterotoxins in coevolution and host-specificity.</title>
            <authorList>
                <person name="Kobmoo N."/>
                <person name="Wichadakul D."/>
                <person name="Arnamnart N."/>
                <person name="Rodriguez De La Vega R.C."/>
                <person name="Luangsa-Ard J.-J."/>
                <person name="Giraud T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000033">
        <property type="protein sequence ID" value="RCI07376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LKCN02000033">
        <property type="protein sequence ID" value="RCI07378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KYY2"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI07378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="108" mass="12594" checksum="EEDA7D5846063F30" modified="2018-11-07" version="1">MGLRAQSPLNPMGIVIAARELGKSDFLSVGHDFLMRKNVGKKWWNRMRYFVGRWRKIKAVKSWLKVEEEEESRDGLKEAIEEELEAGEVFVLRRLVRVNPIDLIDLTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L020</accession>
    <name>A0A367L020_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5701</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000024">
        <property type="protein sequence ID" value="RCI07775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L020"/>
    <dbReference type="OrthoDB" id="4776855at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI07775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="160" mass="18049" checksum="F452562321ED61DB" modified="2018-11-07" version="1">MISYQALLRHTNIVFLFANGISYVNRTQDAWYRGIVQGLPLGEQAGEEQPVWWPAETLSPMGCVHRYQCHPRRDISFQRNAAAQLLLRFPLAGGDARYTLAPILALLERRRMKYTYLELVSNETLQLQRAAYQGIGTGRGEKLADLPLHYTRAGGGDDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0B4</accession>
    <name>A0A367L0B4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Heat-labile enterotoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000023">
        <property type="protein sequence ID" value="RCI07856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0B4"/>
    <dbReference type="STRING" id="1330021.A0A367L0B4"/>
    <dbReference type="OrthoDB" id="4928224at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.210.10">
        <property type="entry name" value="Heat-Labile Enterotoxin, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016968450" description="Heat-labile enterotoxin" evidence="1">
        <location>
            <begin position="24"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI07856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="40548" checksum="72B7415C2438A98C" modified="2018-11-07" version="1">MGSRMSSLTFLSSCLLLSGAIRAQNGQPTGNRFNYSVYPGVRVFYQGTVSPRDVRRQGGILPRNPQPDDDGRWAYWPTFEAREWLSLESEMPDRIERDGPEDQQDRWLYHIAPSPNMVPADEIQTGIMSLGGILWSQVQHLAMVPYVNGSWRDLSHLRWEYNPDFDPRWLAFGISGPQPLLSGLEPLPEGITTRRQLARTYMNELTGPNNPSLSNEQRHTLRELFDWNPETQPNRDFPLIHGNDNPESLASITVREIDWRDTEMADTVRRLEHRARAGFATDALCFDILSQLRHSTSRFRRQTNKMRQKAEEDPQWLTSLSYSLYNTAMKSRSQPELLNEFCRSILLGLALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0U0</accession>
    <name>A0A367L0U0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000023">
        <property type="protein sequence ID" value="RCI07832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0U0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI07832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="47" mass="4987" checksum="576DC2F789923AD8" modified="2018-11-07" version="1">MRERRGERRGGRGEKGDGCFPSSKTRAAGGGGGAVTSRVWIEGNHSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L128</accession>
    <name>A0A367L128_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribose 5-phosphate isomerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_6332</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LacAB/RpiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L128"/>
    <dbReference type="STRING" id="1330021.A0A367L128"/>
    <dbReference type="OrthoDB" id="2106730at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1400.10:FF:000004">
        <property type="entry name" value="Ribose 5-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1400.10">
        <property type="entry name" value="Sugar-phosphate isomerase, RpiB/LacA/LacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011860">
        <property type="entry name" value="Rib-5-P_Isoase_Actino"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003500">
        <property type="entry name" value="RpiB_LacA_LacB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036569">
        <property type="entry name" value="RpiB_LacA_LacB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051812">
        <property type="entry name" value="SPI_LacAB/RpiB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004051">
        <property type="entry name" value="PRK05571.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02133">
        <property type="entry name" value="RPI_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00689">
        <property type="entry name" value="rpiB_lacA_lacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43732:SF1">
        <property type="entry name" value="RIBOSE 5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43732">
        <property type="entry name" value="RIBOSE 5-PHOSPHATE ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02502">
        <property type="entry name" value="LacAB_rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005384">
        <property type="entry name" value="RpiB_LacA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89623">
        <property type="entry name" value="Ribose/Galactose isomerase RpiB/AlsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI08140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="16998" checksum="FAEF97FAA3A63F25" modified="2018-11-07" version="1">MAPSWRIAVGCDEAGISYKEAIKADLESDGRVSEVIDVGSFRGTDKTAYPARAAAAARLVAQGKADRALLVCGTGLGVAISANKIKGIRAVTAHDSFSVERSVLSNNAQVLCMGERVVGLELARRLAREWLGYEFDATSASALKVDEISRLEDGGEEGVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L151</accession>
    <name>A0A367L151_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="9">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L249_6336</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RSP5/NEDD4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="9"/>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L151"/>
    <dbReference type="STRING" id="1330021.A0A367L151"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072666">
        <property type="term" value="P:establishment of protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08382">
        <property type="entry name" value="C2_Smurf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000011">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000017">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000074">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000005">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024928">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF440">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE NEDD-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001569">
        <property type="entry name" value="E3_ub_ligase_SMURF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 9 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="14">
        <location>
            <begin position="230"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="14">
        <location>
            <begin position="346"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="14">
        <location>
            <begin position="405"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="15">
        <location>
            <begin position="494"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="144"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="254"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="212"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="269"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="302"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="332"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10 11">
        <location>
            <position position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001569-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCI08144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="914" mass="102902" checksum="F19E56DE72A10251" modified="2018-11-07" version="1">MAARSESGLPSKSNLRVTIIAADGLYKRDVFRLPDPFAVATINGEQTKTTTVSKRTLNPYWNESFDFRVNEDSILAVQVFDQKKFKKKDQGFLGVINIRVGDVMHALGADADDQMLTRDLKKSTDNLVVHGKLIINLSCNLSTPARGGQSSSSRPNVSTPGAASASSLAAPMAADNRPGSSTSGQNGVANGAQTTLAHHPAGPGPATNTPASNGQSRPISQLSPFEDNQGRLPAGWERREDNLGRTYYVDHNTRTTSWNRPTASGAAESRSDREAATQVERQRHQNRTLPEDRTGTSSPTLQQQNQHQQQGQQHQQQGQPQANSGAAAGAANTTMMHTGATSPGSGELPSGWEQRWTPEGRPYFVDHNTRTTTWVDPRRQQYIRMYGGQNNANGQIQQQPVSQLGPLPSGWEMRLTNTARVYFVDHNTKTTTWDDPRLPSSLDQNVPQYKRDFRRKLIYFRSQPAMRILSGQCHIKVRRSHIFEDSFAEITRQTPMDLKKRLMIKFDGEDGLDYGGLSREFFFLLSHEMFNPFYCLFEYSAHDNYTLQINPHSGINPEHLNYFKFIGRVVGLAIFHRRFLDAFFIGALYKMVLGKAVTLADMEGVDADFHRSLQWMLDNDISGGILEQTFSTEDERFGVMTTEDLIPDGRNIDVTNENKKEYVDLMTFSTEDERFGVMTTEDLIPDGRNIDVTNENKKEYVDLMVKWRIEKRIAEQFQAFKEGFQELIPQDLINVFDERELELLIGGIAEIDVDDWKKHTDYRGYTESDDVIQNFWQTVRSWDGEQKSRLLQFTTGTSRIPVNGFKDLQGSDGPRRFTIEKAGELTNLPKAHTCFNRIDLPPYKNMETLQQKLTIAVEETMGFANYPRFSQSGGGNGGKWMDSPKAKMRVRPPTIDAGAHAVRQQGNYHHGMSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L178</accession>
    <name>A0A367L178_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">LSM complex subunit LSM5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="primary">LSM5</name>
        <name evidence="12" type="ORF">L249_6269</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L178"/>
    <dbReference type="STRING" id="1330021.A0A367L178"/>
    <dbReference type="OrthoDB" id="429711at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01732">
        <property type="entry name" value="LSm5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000003">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033871">
        <property type="entry name" value="LSm5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20971">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20971:SF0">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 10" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="6"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI08174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="102" mass="11032" checksum="A35A62FD753DDFE5" modified="2018-11-07" version="1">MASQLLPLELIDKCVGSRIWVIMKDGKEFSGTLVGFDDYVNMVLEDVTEFDYGTGDRTKLSKILLNGNNICMVSSARLDLPHLLTTSSQLIPGGEGPGEPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L193</accession>
    <name>A0A367L193_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Vacuolar protein sorting-associated protein 68</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_6286</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0220 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L193"/>
    <dbReference type="STRING" id="1330021.A0A367L193"/>
    <dbReference type="OrthoDB" id="268928at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007919">
        <property type="entry name" value="UPF0220"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13180">
        <property type="entry name" value="SMALL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05255">
        <property type="entry name" value="UPF0220"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI08188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="186" mass="20036" checksum="F012B7B12CAAE7BD" modified="2018-11-07" version="1">MEDHRLWRFGRPDWLNSAWARGAGIYAAGALVAWARGAGIYAAGALFSVAFYVMLDSAVWSKSARNGSNVHVRFVDWLPLIFSSLGMLIINSIEKQRLSADSFSYSGSGVAWKARVVLFLGFAALAGGMAGGVTVFVLKFIVPGVSMPALGMGIENIISNALVGFSSVVLWVSQNMEDEYSYNLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1Q4</accession>
    <name>A0A367L1Q4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_6223</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1Q4"/>
    <dbReference type="STRING" id="1330021.A0A367L1Q4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI08152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="162" mass="18759" checksum="8F895FF5131CFA66" modified="2018-11-07" version="1" fragment="single">TRYKDIRTFSRKKGEFSAFLTNLKDKIRTDKATFRDEEDRIGFLFRSLEGKARKTLETRYNSIERPFSRLAEIIYLLTKTKDNSLSYEDFCGYVKDSVYYRKRDAAIKRLDAKLVLVSLVPLVDFQGRLASPPNDLPALAKYSLSILLPKTPLLNRQIDPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1T9</accession>
    <name>A0A367L1T9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">4'-phosphopantetheinyl transferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_8895</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1T9"/>
    <dbReference type="STRING" id="1330021.A0A367L1T9"/>
    <dbReference type="OrthoDB" id="15433at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00101">
        <property type="entry name" value="AcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002582">
        <property type="entry name" value="ACPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004568">
        <property type="entry name" value="Ppantetheine-prot_Trfase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00556">
        <property type="entry name" value="pantethn_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="4'-phosphopantetheinyl transferase" evidence="8">
        <location>
            <begin position="9"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI08378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="131" mass="13910" checksum="F4ACF0DFAD03D0C9" modified="2018-11-07" version="1">MKRLRPGMGIGIDICQISRIASILGSPRRARFLSRILTPDERAGGEARLKAPLKEEAAFVAGRFAAKEAVMKAFSSTRRLGWQDIEIDIVGARPVGRVVGRGEGDGGGEEVLVSISHDGDYAAAFCVAGVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1Z4</accession>
    <name>A0A367L1Z4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_8791</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the histone H4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1Z4"/>
    <dbReference type="SMR" id="A0A367L1Z4"/>
    <dbReference type="STRING" id="1330021.A0A367L1Z4"/>
    <dbReference type="OrthoDB" id="3919494at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000007">
        <property type="entry name" value="Histone H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019809">
        <property type="entry name" value="Histone_H4_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00047">
        <property type="entry name" value="HISTONE_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0488">Methylation</keyword>
    <keyword evidence="9 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CENP-T/Histone H4 histone fold" evidence="12">
        <location>
            <begin position="36"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF15511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI08460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="103" mass="11356" checksum="9392CB0E756752E2" modified="2018-11-07" version="1">MTGRGKGGKGLGKGGAKRHRKILRDNIQGITKPAIRRLARRGGVKRISAMIYEETRGVLKSFLEGVIRDAVTYTEHAKRKTVTSLDVVYALKRQGRTLYGFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2A1</accession>
    <name>A0A367L2A1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">COP9 signalosome complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_8928</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M67A family. CSN6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2A1"/>
    <dbReference type="STRING" id="1330021.A0A367L2A1"/>
    <dbReference type="OrthoDB" id="1378at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08063">
        <property type="entry name" value="MPN_CSN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033859">
        <property type="entry name" value="MPN_CSN6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF8">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="MPN" evidence="4">
        <location>
            <begin position="20"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="217"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU367006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI08545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="425" mass="46359" checksum="9FDED17950CBE318" modified="2018-11-07" version="1">MSAPAFNPLLSGQKSSQLQAVLHPLVLLGISDYIARHGLRNQKGPIVGALLGQQNGREITIEHVFDCHIRPAPEVEGGWLLVADRFAARLEQMTTVHKDRKLELVGWYTLLPTTGPTPAVVPIHNQIIQGWNESAVLLGFHPEEALKDSVGGKLPLTIYESNYEVDQANNTNAGDGDEDNMMDDGDTAALKLRFREVPYSVETDDTEMISMNYVADGGGGNASASTMPAVKEERPARSVESNGKGKRRLVESEAGEAAAATDDDDDSDDDKYVNGPETMKTLAWLTEKANAIKMLNARLRLMITYLERLPPSFVDGEAAVDDMDTDSTTPSFPILRQIQALVARLGVVVPSDTAAFDKEDLRQENDFQFVELLNYLVSNSCMARDVGKKFAVVDSNKTVLARRGVADSLPPNPSFNLSSTGDIFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2A4</accession>
    <name>A0A367L2A4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_8788</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2A4"/>
    <dbReference type="OrthoDB" id="3026777at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="271"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="21"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI08561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="481" mass="51261" checksum="29494B0A1B0DDD6C" modified="2018-11-07" version="1">MEETTPLLGRQLAAPSRSTVLLLSLVIFSLSCFSSVSSVPLNRLLEHRLCRQYGAHHARLSFFDERVCKADVVQSQLAHINGILDTLEAVVGLLVAFPYGALSDKVGRKPVILLSIAGFALGSAWTALILARDQATIQTILLAPAFFLIGGGRHVTYSTVFSAVSDVTTEKTRASAFVTISLGSFMGGVVGPVVSSGLMQVTSPWLPYLMSFAMVLLGAALLMLVPETLPPRKKNPQDDYDDDDDDDDTSILFSYLTRLRASLSMLRKPELALVLVAFLAPVPMSTAANQFFVQYVSKRFFWSMADAGYLQSVRGAVNVVLLLVVLPCLGNSKALLSRASSSSSPAAKDRYLAQLSAVALTLGCLLMAGESMPLVVAGFVVNTLGNGLAPLCRSLAAHLVAAHEQAGLQTLIAIVEASSSLFAGPALASALSAGMRRGGVWMGLPYFGLAAFLFFVTLPLLVPMRTRPRRKLKSGGGIIEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2J5</accession>
    <name>A0A367L2J5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">GPI2-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_4716</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2J5"/>
    <dbReference type="STRING" id="1330021.A0A367L2J5"/>
    <dbReference type="OrthoDB" id="196709at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009450">
        <property type="entry name" value="Plno_GlcNAc_GPI2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06432">
        <property type="entry name" value="GPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="351"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="406"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="171"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="228"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="228"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI08627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="459" mass="51084" checksum="783EF74D29FCC053" modified="2018-11-07" version="1">MPLPTDDDDEGSFTRSHHSPPQDAAVTLSPPRPTLLGGAARHDPLTQRNRSRRRKRAWKRLMWVKQSYPDNYTDQATFLENLQRNPRLKPYDFWPLVNDSTVILQHVCSVIIFIVCFVAIFQERASPVSVVSCGSLATFVGWILWERWVSEEDWQDEVSVPAVVVRSSSTRRRGRAASVRRPQPRADGLLAGGPMTMAAGTTTATATATATATTTTTTLITPIIPENKTEQQQQQQQQQGESPPQEEEEAEEEEDDDDDDENRVYERLETIKSALLIFSTLLGLSPILKSLTRSTSSDSIWAMSFWLLALNVFFFDYSGGVGAKFPASLSTNAGLMASTVLASRLPSTKQVFSLTLFSIEVFGLFPVFRRHVRHRSWRYHVVLTALLVLGAGLGVGIVLGDGQKQSGFVGMVFGLLMAAVAAGGCSWWLIGLQKYKNEIRGPWDPARPIIMSRTRWDGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2Q1</accession>
    <name>A0A367L2Q1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_4815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2Q1"/>
    <dbReference type="STRING" id="1330021.A0A367L2Q1"/>
    <dbReference type="OrthoDB" id="566138at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678:SF34">
        <property type="entry name" value="OS04G0183300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016704807" description="Amidase domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="50"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI08710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="562" mass="60157" checksum="D4F6F19654435524" modified="2018-11-07" version="1">MHLLNFIPLALGLAHAALGAPDASELPSLLDATLDQLRSGLDNRDFTSVDLVKAYTKRILEVNPQLRTVIELNPDALTIAKELDDKLVTDGKPISRLHGLPILIKAAIGTDDKMNTTAGSLALLGAEAKDEGGVVQRLRKAGAIILGKTNMSQWSNIRSGMQPNGWTSVGGQSFGPFYPGQSPSGSSGGSGVAASIGLAWAAVGTDSTGSVVMPSAANNVVGIKPSVGLTSRFLVVPYSKDYDTVGPMARTVKDAAHLLAAMAGPDPRDKATDAIPDGGKVPDYVAACRSDGLKGKRIGVPLISDLEKLNYINESDSQATREEFERALQVLRDAGAELVPDISAPGVAFFHSFEGFGLMFQGVFATLGDVMRDYLSNLKVNPNNIKTLEDVRAFTLKEKREKFPQIPVDTFNDTLEFSFNSTSQQYKELLAKMRFIAGEQGLTGAIKNNSLDAIVAPGFFPVFPASVLGTPVITVPLGRGSEKAAVRFDRSSNTLKESAPNQPYGLTFAGLRFTEEALIGMACAFEERTKVRNQIKPMIVPTTEISDVLKNKESEEDKEKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2X9</accession>
    <name>A0A367L2X9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2X9"/>
    <dbReference type="OrthoDB" id="4926630at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359:SF1">
        <property type="entry name" value="INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE EPSILON SUBUNIT HOMOLOG 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24359">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="334"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="723" mass="82052" checksum="540C2F3D70EC3C88" modified="2018-11-07" version="1">MPDVEEKSVGHVNDIHLEKLPELISYVTGAFAHILCHRDVPHRLRTSLDKQAARFKGWSFVAGFSVNNHAAGRLGNAPAMLGALLAALEYLSIQLRTVDSHLDGQKTPSDGASSLDATLEIESAITTLHQLSISYRRTVLPSPADLLVQLHQSHGQDATAELSIKLLSKRLWSAFSSGYFIPDESLRNVVDEVSTQQVLFETFPEFHSTKFEAYSKLVCQEPGLRKIFALLVLLRKVSALESFIESSINDGCLPLPANGNQLRPSLTDDETRDQFVQLQWLLLAPQLIRNHDNDTASLHRSAIVPCLEAVVIPKFNDNLTDQTSTQTIVLESSPVWKVKIHPGHIAASRRRDVPLCALKQLKGLSKRDAVCEIANLKELRYLTRPQEHMVELLDSFFYRDNFYLVFDWAQDNLLQYWRRNAEPESTKGLFRWASSQMLGLSQGLAAFHDELRGFHGDITPHNILRFTKSDSPRSYGILKLSDFGLAQFLGRGDQEEHFYDMHCDPTYQPPECQPPEEPGDVHTNVTQKSDIWSLGCVYMNFVTWLLRGSKGVEEFSRQRLDEHGTDLQINSFFKVTGEARPVLKATVIRRIEEFESLEKQTQFTLNVMRIIKDNMLTLNPRTRLSCRALSDRLLDIDKKCQDEQHGPGEEMAVLVQAPWVECHMSKAYIKRKVMQRLLKKMFPQISQVIRLRDDCWVLRLPRGITQFGTKLSMASERSGRIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3E5</accession>
    <name>A0A367L3E5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_4740</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3E5"/>
    <dbReference type="STRING" id="1330021.A0A367L3E5"/>
    <dbReference type="OrthoDB" id="5425782at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007567">
        <property type="entry name" value="Mid2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04478">
        <property type="entry name" value="Mid2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016858921" description="Mid2 domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Mid2" evidence="4">
        <location>
            <begin position="188"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI08732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="302" mass="31336" checksum="714B63B12E6E615B" modified="2018-11-07" version="1">MRSPRFCHFLVTVVSLLCVAQALSKNHDIQHKFARQLSGTKDLTSIVAAAPSDAAAKPQSESAPAASATSSSSPSEPSSSSSSSEKSSEKPKASADPTPSPSKQPKPADPEPSSTSSTADSPSSSKAEVAAPSSSESRVERPVSSSEPAATSTDEGSRSSPKPTPTPSVMTTIEIVTMTNSDGSRVQTTTTSRITTTPGLNVGTAPPENSGMSTKTRNTIIGVVVGIGGAVVLGALALFGRRMWWRKRNSEESDGLMDYDMAVTGVEKPDRGSAAAHGPRSPFQSTLENYHQPTQVNASSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3M5</accession>
    <name>A0A367L3M5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Allergen Asp F4-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_4976</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI09024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3M5"/>
    <dbReference type="STRING" id="1330021.A0A367L3M5"/>
    <dbReference type="OrthoDB" id="118256at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019863">
        <property type="term" value="F:IgE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038903">
        <property type="entry name" value="Allergen_Asp_f_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42039">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42039:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25312">
        <property type="entry name" value="Allergen_Asp_f_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016993699" description="Allergen Asp F4-like protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI09024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="36146" checksum="BDF28A77378691EF" modified="2018-11-07" version="1">MKTSLSALLLAAALGAVAHPSGHGHRHFHRSPKTYTTSVAPNKGSNANSVPDNTVDKVQIPPSPKEEGLLASAAAPLAPILNHDGPRKQSSYGGGGGSGIGPDSYEDFCGGAPPSSWKPVCPAGGKWKRATAADVALSGNLGLKDNYGCNLKLVKSNYAEKYDYTFRFKNVGNHKQACVCWLKIGPDGCGINGFWKGKEVMKFDIPAGAEQSLAIQADTKGGCACHKDEMPTTPGVMSPQGFEVGGGEWASTWLEFDMGSIVNGGSSGADASCLAAASVTTKKMDIPGMRVCREDDPSAKCSIIWPGGTGNELAYTKGQEALDGRSVNVGPGPVHYSVEVDYQEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3P2</accession>
    <name>A0A367L3P2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">V-type proton ATPase subunit D</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_4911</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase D subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI09028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3P2"/>
    <dbReference type="STRING" id="1330021.A0A367L3P2"/>
    <dbReference type="OrthoDB" id="7676488at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002699">
        <property type="entry name" value="V_ATPase_D"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00309">
        <property type="entry name" value="V_ATPase_subD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11671">
        <property type="entry name" value="V-TYPE ATP SYNTHASE SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01813">
        <property type="entry name" value="ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="155"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI09028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="22554" checksum="34C13DE0A3893D29" modified="2018-11-07" version="1">MGRVMQIAAFSLAEVTYAVGGDIGYEVQESAKTARFRIRTKQDNVSGVLLPAFESLVAEGSNDFSMTGLGKGGQQVQRCRETYSRAVEALVELASLQTAFVILDEVIKVVNRRVNAIEHVIIPRTENTISYINSELDELDREEFYRLKKVANKKQRDTAEEDAKMNRKRDASATRVDATKSNDGPSAPVTDMLTAEEDDDVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3P3</accession>
    <name>A0A367L3P3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI09051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3P3"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="170" mass="18812" checksum="D7E580361A4C1460" modified="2018-11-07" version="1">MYHDGLAVVLSRICEGNGDNGVTMGLSYNVATKKAERTSMLGVVTGLFVRGKRRVSPIFELTKVGSCQGQMWRPNSGGKEATLSRGPCSPFEGDKQVESHEEVSPKAEDVIRTFFLEEEEEEEEEEVVVVVVGYLKGWLCRMAKTIGSEEAVDLQEQLFPSIKGESFNYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3R2</accession>
    <name>A0A367L3R2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptide hydrolase</fullName>
            <ecNumber evidence="3">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_5129</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI09075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3R2"/>
    <dbReference type="STRING" id="1330021.A0A367L3R2"/>
    <dbReference type="OrthoDB" id="3064516at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05652">
        <property type="entry name" value="M20_ArgE_DapE-like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050072">
        <property type="entry name" value="Peptidase_M20A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43808">
        <property type="entry name" value="ACETYLORNITHINE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43808:SF30">
        <property type="entry name" value="ACETYLORNITHINE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M28" evidence="4">
        <location>
            <begin position="89"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="5">
        <location>
            <begin position="211"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI09075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="399" mass="42176" checksum="8E37DEC8A87EFA8F" modified="2018-11-07" version="1">MRFPTLSVTLTISATPWIVSASQRALTPPLSSAPAYRDDLLSLHRLLVSIESITGNEAAVGRFLEGYLVEKGYEVTRQRVGAAKDDRFNVLARLGNGSSGNRPRVVISSHIDVVPPYIPYGIAEKGGIDRHTIITGRGSVDAKASVAAMVVALEQLRAAKRISDADAAMLFVVGEEDKGDGMRAYAQSLGGTGPPPAVIFGEPTENRLACGHKGITTCRVSAHGTAGHSGYPWLGKSANEIMVRAMAALLDADLGSSSLFGNTTVNIGRFEGGVAANVIPENAVAQLAVRIAVGSEDDGAKTVKRRIQEVLDGVDKEALAMECTEGYGPIKLDCNVDGFDTVVVNYGTDIGNLKGNYTKYLYGPGSILVAHGARENLTVGDLETAVEGYKNLVLHVLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L456</accession>
    <name>A0A367L456_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Letm1 RBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_1428</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L456"/>
    <dbReference type="STRING" id="1330021.A0A367L456"/>
    <dbReference type="OrthoDB" id="73691at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033122">
        <property type="entry name" value="LETM1-like_RBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07766">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51758">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Letm1 RBD" evidence="4">
        <location>
            <begin position="137"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI09215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="336" mass="38238" checksum="9B0F3BFEF5263ACC" modified="2018-11-07" version="1">MYRQTPWRCFAFRGNDVGLWSRTCPTLLRPKAFASRQAHGSSSARLNPPASTRPPPLDVPSRDSVDSTMHYLVQLGKGYVRFYKDGIKAIWGNRKLLRQKLATMPARDRPSVFLPPRNVPEAFSRADWVLLWRVRHDLVRLPLFGLMLIVIGEFTALVVVFVDRVVPYTCRIPKQILSGTTRAENRRRSAFAELEARHPDGALGTSVTQAVARRHVLRSLDLAGGFWDAIGFMPPGMWLAKGRSRIIFLEGDDRRLVEEGGPVGLESAELSIACRERGIDTFGKTKNELCALLSLWLRLTMAENPAERRRRMAVLLLTRPEKWPKQRNFTVPEWEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4J5</accession>
    <name>A0A367L4J5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_3647</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="6">Amino-acid biosynthesis; ergothioneine biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000015">
        <property type="protein sequence ID" value="RCI09337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4J5"/>
    <dbReference type="STRING" id="1330021.A0A367L4J5"/>
    <dbReference type="OrthoDB" id="659at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="entry name" value="paralog of FGE (formylglycine-generating enzyme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024775">
        <property type="entry name" value="DinB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051128">
        <property type="entry name" value="EgtD_Methyltrsf_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019257">
        <property type="entry name" value="MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017805">
        <property type="entry name" value="SAM_MeTrfase_EasF-type_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03439">
        <property type="entry name" value="methyl_EasF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397:SF1">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12867">
        <property type="entry name" value="DinB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10017">
        <property type="entry name" value="Methyltransf_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine-specific methyltransferase SAM-dependent" evidence="8">
        <location>
            <begin position="41"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="DinB-like" evidence="9">
        <location>
            <begin position="352"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase-modifying factor enzyme-like" evidence="7">
        <location>
            <begin position="537"/>
            <end position="806"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI09337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="809" mass="90687" checksum="7A64C87C0C2BAEA0" modified="2018-11-07" version="1">MPAVKESVLGRDDDGGGGSRTPLDIIDIRSRVEVRNIDLRAEITYLDEYYLTNYEMGLLKQSAAELAGSIASGSMLVELGSGNLRKVSILLQAFEQLAKPVDYYALDLSKQELERTLAHLPPFEHVSCHGLLGTYDDGREWLKRPEMLRRPKCILHIGSSIGNFSRVDAAEFLDGFAELLNPGRDCMLLGVDSCNVPAKVHHAYNDEDGITHEFILNGLTHANNLFGKAVFDVAEWRVIGEYVYDDEGGRHQAFIAPVRETEVLGVVIRPHERVQIEQSLKYDERERLRLWKQAGLREEASWLRGDEYGLHLLRRDSLPFPRNPGLYAATVLPTIAEWESIWKVWDVATCSMLSSDQVSKRPIDLRNPCVFYLGHIPTFLDLQLSRATGTASTEPNSFATVFERGIDPDVDDPRRCHAHSAVPDCWPPFDDILAYRDRVRDRVRRLYAEAQGKLPRHVARAVWVGFEHELLHLETLLYMLIQADDTLPPPDAPRPDFELLAEKAARERVPNLWFDVPAQTLVVGMDDPEHGTDQSLPFGWDNEKPSRSVPVHAFQAQGRPITNEDYARFLYNSGIEQVPASWSCVEDLPAATTGAVHSTLPGSFLRGKAVRTVYGLVPLAQALDWPACASYDELARCASWMGGRIPTADETRSIYAYVEAQKKEASTQSRLSKKVPAVNGHLVNDGVTETPPSTDAMSQLHVDLGGVNVGFRHWHPVPVTSRGGSLAGQADMGGLWEWTSSPLRRHPGFEPMSLYPAYTADFFDDKHNIVLGGSWATHPRIAGRKSFVNWYQRNYPYVWAGARLVRDIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4R6</accession>
    <name>A0A367L4R6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_3648</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000015">
        <property type="protein sequence ID" value="RCI09401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4R6"/>
    <dbReference type="OrthoDB" id="9970474at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.400.10">
        <property type="entry name" value="Acetoacetate decarboxylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023375">
        <property type="entry name" value="ADC_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40518">
        <property type="entry name" value="ACETOACETATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40518:SF1">
        <property type="entry name" value="ACETOACETATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160104">
        <property type="entry name" value="Acetoacetate decarboxylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI09401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="286" mass="32213" checksum="1A4A0EBE72391DC4" modified="2018-11-07" version="1">MRRDDIVVGNPIQLIPPPWHVTGDVYCLSFWSSSATARNLPAEHIFSPLEASDPNFANPPGNRPAGGLGMIQIIRYHDSPVGPYDEMLVVPGSFDWVRRRPDGKDELGRNPRVSRIYVSQRQTCHNGRINWGCPKHLARFEWTDDDSGSMTVKVFPHDTAGDRSEASPSPVPFFQASFKPVSYAPRFPFATRWLGLLGFNTTIVMPPLPRGPGSQGELPGTDRWCSFLPNQYSRSTRVGWFDLAQAENSPYDNFWPGLGRWQLGFKMEKADVVFDKPLDAWPRAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L514</accession>
    <name>A0A367L514_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP12 chaperone protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_3948</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L514"/>
    <dbReference type="STRING" id="1330021.A0A367L514"/>
    <dbReference type="OrthoDB" id="5322896at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3580.10">
        <property type="entry name" value="ATP12 ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2180.10">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011419">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042272">
        <property type="entry name" value="ATP12_ATP_synth-F1-assembly_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023335">
        <property type="entry name" value="ATP12_ortho_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013:SF10">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21013">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 2/ATP12 PROTEIN, MITOCHONDRIAL PRECURSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07542">
        <property type="entry name" value="ATP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160909">
        <property type="entry name" value="ATP12-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI09514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="371" mass="40640" checksum="857E34D39A09D2E2" modified="2018-11-07" version="1">MINIHAQHCSRLLSRLVNGSRHSRFLQLSVGRPARVSPDVGAGPPPDPPTPTDNRYLAREARRYDAAADLRVSNDGKNSLLRKRFWQGVSVRSVNGALEVYLDERPLKHPRSKKVIRLPPSKPILAIALAVEWDRLTSAQQATKEHLVPLTSIICRALDIEADDGSGLGKMRGDITANLLKYLDTDSLLCWVPPANELDVLNDANESLRDVQKRAATDTVTFLTMHVWPGVTIEPVLDGHSLSPRKQAPGVREIVQGWVQGLSSWELAGLERAVLAGKSLLIAARLVAQWSEEAAGARVPATDEHGFRVEDAVEAVSIEVDWQTEQWGEVEDAHDVNHEDLQRQLGSVVLLVSGTRADASNLFPPGITGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L516</accession>
    <name>A0A367L516_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein EFR3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_3924</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EFR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L516"/>
    <dbReference type="STRING" id="1330021.A0A367L516"/>
    <dbReference type="OrthoDB" id="19232at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039786">
        <property type="entry name" value="EFR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049150">
        <property type="entry name" value="EFR3_HEAT-like_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47766">
        <property type="entry name" value="PROTEIN EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47766:SF1">
        <property type="entry name" value="PROTEIN EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21072">
        <property type="entry name" value="EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="411"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="475"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="601"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="901"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="956"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="495"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="923"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="968"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1007"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1028"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1044"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1068"/>
            <end position="1079"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI09533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1121" mass="120587" checksum="7C55A7B8A2A90907" modified="2018-11-07" version="1">MNALQQKCRPKHQVLVLRCYPRTTKGAVDVRPNSSELSYLLFYATSRRSKIQKIGAFLEKKTASDVWRMRIGNVQVTLGILAAVVEKSPKDLALIAPCIFKVLDLILRSNDITMIESSLPTFQAFCEHHDASTLFADHAYLQQYRVIVAAYAQLASSRHVPAKGTTVSRPVQMRWRNAGLDAIKCVSSSAALSSVFGRQIDVIVPVILDNMSTADDDIEALLSRLQAEERVDAGRAMHRRMSVATVKTNDTAGDTNPLALSGTALEVDKMDEQGLGVLAMQCLKSIFVVHNRTQIHAATMAMLQFISHRSSRGEPVVTREEGAACDSGWAIDVYDVVARWAPVQDRYVILLAALDTMFKTPLTDADLGLHLTLTGMIQSLLRSDINLIGLSVMDVVLGLAGQIKKLIRTRAGAHDGSSQSEDKTDAESSGPSVRVQRRRLIERLEQCIGDLATHVYYGDQVSDMVVALIGRLKPGRSSSATSLPLGEDVDGGNEGSNPSAVDLSGNQSSSPFTDVDLAYGSLRASALRIIKAILVVANPKTSMGGTKDLSRNRVPMTVWEGTQWLLREPDGPVRKAYVDALLTWLDRETTAADATARDEFLPVTHHRPSTRSASREPSQARRAVSNASNRERQSRAGRRSQFLPLLHLAVYDSAHQFVDFDSDMALLHALLARLVAKLGVNAARYGIPMIYRLQEDVQYVEDPVHKVRMAALCHGYFWALTQRFDLEGTVGGRAIQNEIARRKSKGFWVDSLRVPPLPLDGIGTPGQAGPQPSWELRALEKEELLPFDDRASLVHCIAASYRESRLSPPASPVASPGRGQHAVTVPLLGYSMATGPEESRELPVALREGMLSDWSRDSAVAALSDSKAASLNGSRTGTTGTANQKRLTVYSAGLNGGASPMGSANNLRLQTPGERVSGASRPRNASVQSGISPTASVSSRGGIASVEQLKMVLTGNASPRGAGIPGVGEDDSDESMVSFDEDEDDESRSEHSSVFKGGDGLGRMVSKTVSRTGSSKGPLTSHPLLDGEGGDDGDDDGDADGGVPPVPPLPKLPPLSLSGRAVQDYGGRRSVSSTTTRARTGSREGGASMGSSRGMDLQELLRGIDSRASEGSLGNATKPPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L590</accession>
    <name>A0A367L590_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Very-long-chain 3-oxoacyl-CoA reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_4022</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L590"/>
    <dbReference type="STRING" id="1330021.A0A367L590"/>
    <dbReference type="OrthoDB" id="5545019at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045703">
        <property type="term" value="F:ketoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05356">
        <property type="entry name" value="17beta-HSD1_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000317">
        <property type="entry name" value="Very-long-chain 3-oxoacyl-CoA reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03107">
        <property type="entry name" value="3_ketoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027533">
        <property type="entry name" value="3_ketoreductase_fungal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086:SF2">
        <property type="entry name" value="HYDROXYSTEROID DEHYDROGENASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43086">
        <property type="entry name" value="VERY-LONG-CHAIN 3-OXOOACYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000126">
        <property type="entry name" value="11-beta-HSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI09595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="383" mass="41529" checksum="FBE9529E932CAE71" modified="2018-11-07" version="1" fragment="single">PRPQARFVSLPALGSCNFKHPTPGTSPSHQNSQSFALLVLSHSISCFAIMESVQGCLSKLPPVVQLALASVGAICLGSKLLSFLQLLLSCSVCSGLNLRKYGKAGSWAVVTGASDGLGKEFATQLAAQGFNLILVSRTQAKLDTLAAELEQKYTGKGLQVKTLAMDFAKDDDTDYEKLAELIRGLDLAILVNNVGQSHSIPVSFLETPREELQDIVTINCIGTLKVTQAVAPLLKARRRGLILTMGSFAGWTPTPYLATYSGSKAFLQQWNSALAAELADDNVDAYLVLSHLVTTAMSKIRRPSLLIPTARGFVRSALAKVGLGGYQSAPNTYTPWWSHAAMLWLIENVPGVNSRLTIGQNKKMHVDIRRRALRKREREAKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5L4</accession>
    <name>A0A367L5L4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5L4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="101" mass="11800" checksum="796F0C1FDEA5833F" modified="2018-11-07" version="1">MQQIWAITRKVVSLFDNMIQDPPSTMAEMNEQIVDFNGEMEEVAGSTVYQTREFYRRETWPRLKLFVPDEVEVAPLVRRMRKRKASEADDMTTGNLDSPDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-05-03" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L642</accession>
    <name>A0A367L642_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_8421</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI09889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L642"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI09889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="115" mass="13236" checksum="D9CB9DA60566CEAA" modified="2018-11-07" version="1">MDIYRCGSMDVTVQARALGPYSLHFDRDFQQMNGARCQGRRAFFFSSSFFLFILDPWWDCDSLKPETKHLGAWGTCCIFWCGFTIQGLNGHGKEKPLADAVHWVETMAELFLELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L659</accession>
    <name>A0A367L659_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI09888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L659"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="75" mass="8160" checksum="C2A6A3595FF0FAF8" modified="2018-11-07" version="1">MTPFYRPIIKCHFSFGKESTSMEKPVFTFGRVSTAPPPGWPTSQKVSQLLRDGNDDVKGPAGHVGRGEANGSGFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L723</accession>
    <name>A0A367L723_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial import inner membrane translocase subunit TIM17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_8569</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L723"/>
    <dbReference type="STRING" id="1330021.A0A367L723"/>
    <dbReference type="OrthoDB" id="2261329at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485:SF0">
        <property type="entry name" value="AT05822P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI10022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="154" mass="16152" checksum="00F9C8B05521C6EB" modified="2018-11-07" version="1">MDHGRDPCPWVILNDFGGAFCMGAIGGTIWHGIKGFRNSPYGERRIGSITAIKMRAPVLGGNFGVWGGLFSTFDCAVKGVRKKEDPYNAIIAGFFTGGSLAIRGGFKSARNGAIGCAVLLAVIEGVGITFTKFFASGTKLEVPLPPPNMEPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L740</accession>
    <name>A0A367L740_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L740"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="76" mass="8708" checksum="CDBA111BC69B2E86" modified="2018-11-07" version="1">MSLYQATNENKLPMLYYAIHITIDRDSRFGRSLNSAQPETRVSIRHTTPHGEKNNSRCSRYSRSPSLVHGFSPSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7D5</accession>
    <name>A0A367L7D5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">sterol 22-desaturase</fullName>
            <ecNumber evidence="13">1.14.19.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">L249_4306</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>5-dehydroepisterol + NADPH + O2 + H(+) = ergosta-5,7,22,24(28)-tetraen-3beta-ol + NADP(+) + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:33467"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:18249"/>
            <dbReference type="ChEBI" id="CHEBI:52972"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.19.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:33468"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="12">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.41" evidence="13"/>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7D5"/>
    <dbReference type="STRING" id="1330021.A0A367L7D5"/>
    <dbReference type="OrthoDB" id="1372046at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000249">
        <property type="term" value="F:C-22 sterol desaturase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11082">
        <property type="entry name" value="CYP61_CYP710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000021">
        <property type="entry name" value="Cytochrome P450 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF228">
        <property type="entry name" value="C-22 STEROL DESATURASE ERG5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="15 16" id="KW-0349">Heme</keyword>
    <keyword evidence="9 15 16" id="KW-0408">Iron</keyword>
    <keyword evidence="11 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 15 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="15">
        <location>
            <position position="482"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RCI10329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="538" mass="60708" checksum="38BA1C491E025566" modified="2018-11-07" version="1">MDSVNASSSSPAFTLAPVIANAKYAVSPQLDRFFDLMTSAGFWSLLLAVVVLCVVYDQVCYISRKGSIAGPSWKIPFIGPFLQSVDPKFEEYYAKWSSGPLSCVSVFHKFVVIAATRDMARKVLNSPSYVKPCVVDAAHKLLGHDNWVFLDGKSHVDFRKGLNGLFTRKALETYLPGQEAVYNQYFKKFVDVTKQNDGKPVPFMPEFRELMCAVSCRTFVGHYISDEAVKKIADDYYLITAALELVNFPVIIPYTKTWYGKKAADMVLAEFAKCAAKSKVRMAAGGDVTCIMDGWILQMMLSERWREAEKTASTEKMEKPSPLLRMFSDFEISQTVFTFLFASQDATSSASTWLFQVTAQRPDVLDRVREENLKARNGDVDAELNMDQLESLTYTRAVVRELLRYRPPVLMIPYMVKKAFPITDSYTVPKGSMLIPTTYMALHDPDVYENPDHFDPERYYSGDAEVKGAKNYLVFGTGPHYCLGQVYAQLNLALFLGKASVQLKWTHHPTPLSEEIKVFATIFPKDDCPLTFEERRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-05-03" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7H5</accession>
    <name>A0A367L7H5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_4257</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7H5"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI10374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="274" mass="31364" checksum="ABE69AA58EB490B6" modified="2018-11-07" version="1" fragment="single">MKILTEDRLWKIAKKALIKYYSALDSAQKDTLDERLRNYNAKCPETYEQGYKEAVKFFPEEKRPTSPERIYKKSFNKANKKTIAPNLVLTKVDDLIKQLSSLSINIANIQDKLYSLTNRERNRYALGFYSRLIVTAGVQGQDVEASSDAEDRDIAINIISNNLLDPSPGDRCVQPYNFVNAYELKRPRYKGILTLIDKKAPRKRLSSRQLTFVVDLTLNFGRIRVNYEAFTDKIQVRVGSLKSPIMLALLDTSAETNILTASAARDLNLEYRPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7P5</accession>
    <name>A0A367L7P5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7P5"/>
    <dbReference type="OrthoDB" id="4492972at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="261" mass="28126" checksum="ED4F0400058F25B3" modified="2018-11-07" version="1">MALINPVQTLFVPFLLILMLPLAVFAGITTTLAFSILSFRVVAVYLDMALSLVPQCFSSSASDANSASANSHHHSHRRHLSLSPATSSSSTQSLENSPTTPTHPHLLHLHLHQAQSVPRRRPRRPSSLTSVVSAGSVTTPGGEMAMGLMPSVGPERDFEGVGGWREDRDGDDDTWTTINSRFELPDRIHARNHHRSPSGGPVTPGDTGVLMMKGRARSPAISPSPNSSRARTPSVSRTMTASDGYFSLTMSPTTIKKPLMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8C4</accession>
    <name>A0A367L8C4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tyrosine specific protein phosphatases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_5239</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8C4"/>
    <dbReference type="STRING" id="1330021.A0A367L8C4"/>
    <dbReference type="OrthoDB" id="432447at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057023">
        <property type="entry name" value="PTP-SAK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22784">
        <property type="entry name" value="PTP-SAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017049630" description="Tyrosine specific protein phosphatases domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="4">
        <location>
            <begin position="146"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI10683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="245" mass="27337" checksum="C2D5AE09F5D6CA26" modified="2018-11-07" version="1">MHLLPSLLLLLLSPLLTTSSPSPPGKNPLSGVKNKVLAFFSHNPPPRACPGPSSEGAAPFDIAGLHRFEWVVDGVLARSSAPYYRCRDGDQHLTGETMTFLKRQSIKHIISLNVEANNKTMSETIRRAKIDYTPIPVRDFHSPTFADFNTAFEAFRARRSARTLVWCGYGNGRTGTLVVALLMYLEHHKPRPRFFGQADYRKYHVETAGQVQALDRLQAELTRRRAQGQGKAKGKDVGGKKKPKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L922</accession>
    <name>A0A367L922_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_5174</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L922"/>
    <dbReference type="STRING" id="1330021.A0A367L922"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI10732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="111" mass="12633" checksum="59D85DA04AD54F1F" modified="2018-11-07" version="1">MSYLSVKITDFGEAFFTNSPPHPLHTPLPVRAPEVVFGDRLDFRVDLWSAACMIFELVTGQPPFDVIMWTPPVLVQQIMEFATDEMLSRWQAMCRAMQEGISPEDDNGTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAE9</accession>
    <name>A0A367LAE9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Heat-labile enterotoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_7680</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAE9"/>
    <dbReference type="STRING" id="1330021.A0A367LAE9"/>
    <dbReference type="OrthoDB" id="4925184at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.210.10">
        <property type="entry name" value="Heat-Labile Enterotoxin, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001144">
        <property type="entry name" value="Enterotoxin_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01375">
        <property type="entry name" value="Enterotoxin_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0800">Toxin</keyword>
    <keyword evidence="3" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016827786" evidence="5">
        <location>
            <begin position="33"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI11400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="542" mass="60237" checksum="3B1CE85A984239A7" modified="2018-11-07" version="1">MTITSPTRLYAAATTALVLVVLVVLFPAVTTAQQRYPPASDNMFSYSPSAQATVFIAFLMGQAGDEDADRHSPLYFRRRGGIGDVPGDLRGSSPYADTEYGYETMSSRQGGTGPWIRLSLNLSSEVENLQGGYRSFIVYAVSTSPNMMPSSDSDRSRVSALGGIPWSQIRAWAYLNWDQWRMPQSLDWERNVEHDERWHHFGANVAQPLLSGRRARPDSLFIRHVAWHYLRFITQPNHPERNLLSQLLDWRSYAEPRDFPLLRHGLRDEEGQQLPAPEPAAAAAAAASASSSCDASSRQPNSLQYSILSQFDWDNVDASIPEFIRHGMRNTPRPTTRLCDAALFSLRGLYFTTTKRQQPTPQPPPAAADIFDSCRENDRSSCLQAADLVKNSCDSITALHVDFSLGEKGTADAIGLQVGGRNRPEAMIPLVPPSSGTAHKTVKNHRVDLRRVFDSDVVPLRDIVYVVLYDTPLVVGTDAQDWTMGGITLTASCANLTQKMEMSTYSSVNEAVQNSSPSTNRLPQMVWRRDITREDWKIVVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAJ8</accession>
    <name>A0A367LAJ8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nuclear pore complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_7333</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Part of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
            <location evidence="11">Nuclear pore complex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS37 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the nucleoporin Nup84/Nup107 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAJ8"/>
    <dbReference type="STRING" id="1330021.A0A367LAJ8"/>
    <dbReference type="OrthoDB" id="3098at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000813">
        <property type="term" value="C:ESCRT I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072666">
        <property type="term" value="P:establishment of protein localization to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043162">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037202">
        <property type="entry name" value="ESCRT_assembly_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009851">
        <property type="entry name" value="Mod_r"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007252">
        <property type="entry name" value="Nup84/Nup107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003:SF2">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003">
        <property type="entry name" value="NUP107-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07200">
        <property type="entry name" value="Mod_r"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04121">
        <property type="entry name" value="Nup84_Nup100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140111">
        <property type="entry name" value="Endosomal sorting complex assembly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51314">
        <property type="entry name" value="VPS37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="8 11" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 10 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VPS37 C-terminal" evidence="13">
        <location>
            <begin position="1051"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="66"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="909"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI11441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1144" mass="128102" checksum="1281CCBE56808356" modified="2018-11-07" version="1">MESKREPRNVNGIQGTSSMAKITPGPLVEAFASALDGCIVPNLSATEKRAQILDLPRKFHESAIRRLMQKRPRRSRDGNDDVDMEVDEKDNTKAKSKQQEKVKMLEKEVQLWDLVRRLLPLRYSGSQTASSLFDVTAAQSKPLQASSLDVFVDADPVIKERRAVLQWLQTTAASGPDIDELARDLQQNADRGDIIAHGWLHTRSRIKLRKNITAWPYLLDKQDPSVAASHTNSDGSLLVTHLDPDAATRQVRKLEPQDEYFERAIWLGCFEHLRRGSSLETIRGWCHERTEMWRAISMSGILLSADGKDRLTEVPPKSLVVWRRMCLSLARNGGTDDYERAVYGLLSGDIPSVEKVAKGWDDYLFAHFNALVRSQIDTFLLGLCPPELTSKLAHAFPPTDAIQFRLDLDSAEKRLIATLESQKDTRGDALEPHKALQASLIANDLDRHLYEQARILVEDASNDPQSSLLPLDPLPMRPMMRGKDDFVREKFFRLEQHEGLRIVSHVCVLISLLRQLDEKEGISRFTLKFSGTDSALENIIAAYADFLQRANQKELIPLYCTVLKPPRRYEVLSWNMIKETDASRRMTQLKIMEKLGTSVLDFARTLAKLVFAQIEKSAGHVAETKPFSIIAPGPKHELLINPVFGADKGSAEISRMDEQIIRCLEWLFLVDTAWPELLHFGVKAYKFFFESRHLLATRSLMERVQFEAILETLNEEDVDNAMLDSVIFWARYLEQSGITGEKPEQVVTNARDYRDLENLAKALDCLDDVGSAMRNMPGISPADDKPWRNLGNDIKTMKERMGPLQKGWLLTSIEAGDTELHKLRQSYLPEVILAMLVGMYVAGTNLSRDNLLESMDLAVTIAQSDSDLAKSRALATAKSDKRAAGSSSKRMRQLGWSRGLWSVKRMAGLPPDIDAASTPPAPPPKSGSHDTSRIGTPAPLPAADDSLGDGAAKPFPQSDIGPDPGPGWLPALLRDKSAQHLTELLGSPSLLDALTHAPQAAHPTLSASHADLAHALSHNAQLATQLSTLATRLSRQRFSTQAQLLSTHALERQWRQKQSDMDLALAPFSPASLYQRLAQGVHEQVAVCHALEESFLDAETETDGPASEREVADWVRRYRDAKVQLYLRQERKERWDEGRVGGWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAP1</accession>
    <name>A0A367LAP1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DNA repair protein RAD16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L249_7694</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAP1"/>
    <dbReference type="STRING" id="1330021.A0A367LAP1"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16567">
        <property type="entry name" value="RING-HC_RAD16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="403"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="744"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="825"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="266"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="320"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="332"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCI11498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="993" mass="110919" checksum="138FC44900BF8915" modified="2018-11-07" version="1">MPRRPRQPVQSLKSPSEASPVLDNGTRRLTRSSSLRTAARPSTPSGSQDSPLATVKRPRGRPSRASLLPIATASSSSPSGHHTRHTAAQDTVVVSEPVSSVSSASDISSNGAYSTPATSKLPTPSVVLGPKKSNTSLQVQLPSTPGSSMKSERVLRNSLRSSYMRDSVESDDDHLQPTTFAGRNSTRNLKRPRSPSSSLTSLPPSKKNKSTTTDVATEAVTGDSDGSGSSSDSNPMFTSDSDSDSDLEPLSTRRRAPRASRVEVISDSEIDDSDSEIDDSGSDIDDSDSEIGDSDSETDDSDSSSDPSTGFASAVANDPEAERERADNVRRLAARRRGYRRSHNDARVKRERNRLEYHHPEITTMWTELEKTAVVKPPMATQPQTISRRLKPFQLEGLAWMQEMEKTEWKGGLLGDEMGLGKTIQAVSLIMSDFPAQQPSLVLVPPVALMQWQSEIKDYTDGTLKTIVFHGTNQKTKGMTVKELKKYDVIMMSYNSLESMFRKQERGFTRKNGIHKEKSVIHSIDFHRIILDEAHCIKTRTTMTAKACFALKTRFRWCLTGTPLQNRIGEFFSLIRFLNMKPFASYLCKQCSCTSLEWNMNGDGRCGGCRHTGMQHVSVFNQELLNPIQKFGNVGPGREAFRKMRLMTERIMLRRLKKDNTKSMELPVKEIYVDRQFFGEEEYDFARSIMNNGQRNFDTYVAQGVLLNNYANIFGLIMQMRQVADHPDLILKKHAEGGQNVLVCCICDEPAEEAVRSRCKHEFCRACVGAYIGSTAEPDCPRCHIPLSVDLEQPDVEQDEGTVKKNSIINRIKMENWTSSSKIELLVHELHKLRSDNASHKSIIFSQFTTMLQLIEWRLRRAGITTVMLDGSMTPAQRQASIDVFMNKVDVECFLVSLKAGGVALNLTEASRVFIVDPWWNPAAEWQSADRCHRIGQTRPCTITRLCIEDSVESRMVLIQEKKTSMIHSTVNGDEKAMETLSPQDMQFLFRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAT4</accession>
    <name>A0A367LAT4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7733</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAT4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI11538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="89" mass="10072" checksum="CEA2861C759988EA" modified="2018-11-07" version="1" fragment="single">MSIRTHKIHTLFGKLWLHISPLVRSLNSEAAFPFPVYWQYVRGISMSSGQLSYASLPSEAKWIEEDARHVKLAATIGEGGGGFMMRHRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAY5</accession>
    <name>A0A367LAY5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_7772</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAY5"/>
    <dbReference type="STRING" id="1330021.A0A367LAY5"/>
    <dbReference type="OrthoDB" id="9994905at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="3">
        <location>
            <begin position="187"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="470"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="529"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1029"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="930"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="547"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="582"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="597"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="670"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI11576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1098" mass="119177" checksum="E413D96686DD853B" modified="2018-11-07" version="1">MAEPRRLSASNSAQHLPGATTSGQRVPPSASSVSLAFPQSTSMHSLLASQVRSSGTWTTSSGELGLLSDTDEVEDRAIFVHEYNRLAKKHGVRLLIVDDFHEEQQCHNMAKSPEKRGWLYRLLRANNEQTTSSPGQLQLRHKRSVSDLAHMIRSRLEPPRVVYIQDMVRLSGKSMLYLPQDYAPCSLVLPTCLRATAQHLAQNANTRGLFRIPGSVKVVTALFDYYCCPEPGGESISSTVRCANLPMHIALSVHDVASTFKKLLSVLPGGILGSLSLFDALVAVHSQLNGEPEFPRTKQTKVRARLIALAIGTVKSQFRRELICAVLGLLSLIGRVAEVTPREDADGRPLPTANLMGYGALGIVFGPLLVGDLLDQYTMKLATPTGGLLLLPFSPPKLRRERRRTRPDGNRSGPPTVNKIMVANDIAEMLIANWRDVVRQMRSLGAHHHRKGSSLVNARGTSVSEPFAIKMPRDLDAVQKGPNQSKGEHEGPEPDTPTMGLKRRRNRPVNMAPHPKLLSKVSMQTLTPTIEEGSTEETSARLEAVSEQDRGKDVDGEAVPRPEVAKSVLGEVKAKGPKDTIPAPPPILPQRVPPRLSSRSNRSQDCSEVQTIKSCGTEGDSSATKGQMAKASRKRRQSKTSNNTGSHDGLRGSIGNTPDHLYPPTDGRSRSSQGVSEDMTQVAARRQPGSPTPGNEGRHGSKQAEASDPPFNAGPATGEKSLATQAPASKPHRKRPVRFLVQSPSHSDSSERLSKKGSVKAMAAMFEGQGLNLARMSCPGHGEGANEGAELLQQTASPCPCQLLGRGDGCASDGLVASPQDDQAMSSRAGFMKDAAAVDEPPCRHIAARRSLPMLPPCLSCSSPVHAQELRWACMGHDKEQVPVAQCRKLTRSLSMPPLGYQAAGEGRVLDAAAHPADTLWGSSALFCQMHKLQRRLSIEAEEAAQLRRQLESREDAEVGALSRELSTARRDKSMWKERAESAERRVKAFERFAARMRDLKESIMASQHGVDETAGRPQPRNEVAKDMGSNARSAHKSSAEFGGTTMGSDGAGSRREFLSRQSAEAEQIWAAMEELLRMEDVEELLRMKEGGAAEGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBF8</accession>
    <name>A0A367LBF8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7614</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBF8"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="116" mass="13941" checksum="7CBC6FA3BA58737D" modified="2018-11-07" version="1">MRFSFERRGEEEWEEEEEEEPRRERRRERRRRRSEEEERKRGADKKECHAAWPCQTHSPNEQNHKQKEGGGMNASELTDHHLRPPDIYNRLLPINSPSITGPSTDDEQKLHPITML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBJ0</accession>
    <name>A0A367LBJ0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">ATP-dependent RNA helicase DBP8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L249_7157</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBJ0"/>
    <dbReference type="STRING" id="1330021.A0A367LBJ0"/>
    <dbReference type="OrthoDB" id="10261904at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17955">
        <property type="entry name" value="DEADc_DDX49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF24">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="14">
        <location>
            <begin position="76"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="107"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="319"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="76"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCI11808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="507" mass="55744" checksum="5264343B44D36499" modified="2018-11-07" version="1">MSDWTSESDHLDSSASRKKRRKEAIGDGDDDDDGSPPPPTTLSALAAAPSRVRRAANRQPPEPTQSRILAPTDARTSFSDLQVRPWLVQSLASMAIKRPTGIQKGCIPEILKGRDCIGGSRTGSGKTVAFAVPMLQKWAEDPSAIFGLVLTPTRELALQIYEQFKAISSPQSLKAMLVTGGSEMRAQAIALAARPHLVIATPGRLADHIRTSGEDTICGLRRVRFVVLDEADRLLHAAGPGSMLPDVEECLGVVPAAGERQTLLFTATVTPEVRALKSMPTRPGKEPVFVCEVDSQMLAIPATLTQTHVQVPVTHKEHYLHVFLLTEANKEKTVIIFCNRTSTAEYLHHLLRLLDHRVTSLHSKLAQKQRIDNLGRFRASAARILVATDVAARGLDIAEVGLVVNYDVPRDADDYIHRVGRTARAGRKGEATTFVGQRDVELVTAIERRVGRQMEAWREEGVNLESRVLRDGLKLVSEKKREALLEVEEGREVGGKRKRTKLKLRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBZ1</accession>
    <name>A0A367LBZ1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sulfatase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_4576</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000008">
        <property type="protein sequence ID" value="RCI11935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBZ1"/>
    <dbReference type="STRING" id="1330021.A0A367LBZ1"/>
    <dbReference type="OrthoDB" id="96314at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16032">
        <property type="entry name" value="choline-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000032">
        <property type="entry name" value="Choline sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017785">
        <property type="entry name" value="Choline-sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025863">
        <property type="entry name" value="Choline_sulf_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03417">
        <property type="entry name" value="chol_sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45953">
        <property type="entry name" value="IDURONATE 2-SULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45953:SF1">
        <property type="entry name" value="IDURONATE 2-SULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12411">
        <property type="entry name" value="Choline_sulf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="5">
        <location>
            <begin position="26"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Choline sulfatase enzyme C-terminal" evidence="6">
        <location>
            <begin position="494"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI11935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="564" mass="63739" checksum="0BC41947BB8E9815" modified="2018-11-07" version="1">MSPDLNSLPLSAPLASGPKGPDGSRPNILYIMADQLAAPQLAMYNAESQIKTPNLDRLAAGSVQFDSAYCPSPLCAPSRMSMITGLLPMKIGAYDNASQISSEIPTYAHYLRSRGYHTALAGKMHFVGDDQLHGYEQRLTSDIYPADFGWAVNWDDPEARLEWYHNASSILQAGPCGRTNQLDYDEEVMFRSTQYLWDHVRQSPDHKRPFALTVSLTHPHDPYTITKKYWDLYEDVDIALPKARIPKEKLDSHSKRLLRVCDLWHHNLTDSQIRRAKRAYYGSVSYVDDCIGRLLETLRDAGLADDTVVIFSGDHGDMLGERGLWYKMSYFESSVRVPLLVNYPRWFAPRRVTQNVSTLDLLPTICDLIGVKPAPYLPMDGVSMLPHLLGRDGGHDTVLAEYTGEGTVRPIMMIRRGPWKYIICPADEPQLYNLRDDPLELDNLATRLRNNNGATNGGGIVIKDNPALAEARMILAQYDAEAKTRWDFDAITAQVLQSQRSRRLVWDALKQGNFTSWDFDPIDDGRTKYIRSTIPLDELERRARYPFVDSKSHTVVKTVDSTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LC63</accession>
    <name>A0A367LC63_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_1071</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LC63"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI12006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="296" mass="33202" checksum="04922AB1D7DF956B" modified="2018-11-07" version="1" fragment="single">AGPRPPYVTEAVRTAQQRRRRLRHGYAVQRLRPYGPYGPYKGRNIGYGYSYGYGKRPRCYKSFVVLFFVVFFFVLIEDLPWPAVKIALLRYYGAFNQIRTVGFYEKLRRHEARRLKTKDTIDWLEKHAFLCRKIGSSYGPGPGPGPGPGPGPGPDESTEHSYGLFQALPKEIQVQLYDQLGQRPSSSPYGILRLFLPLSSFLSFLRLSAGLRCTRPEGLGGSRDAGPAAAGPRPPYVTEAVRYSGYTRRLRHGYAVQRLRPYGPYGPYEGRNGPILPSLEQVKQGVPSLAIQSASV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCH4</accession>
    <name>A0A367LCH4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase small domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_0712</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCH4"/>
    <dbReference type="STRING" id="1330021.A0A367LCH4"/>
    <dbReference type="OrthoDB" id="194386at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035657">
        <property type="term" value="C:eRF1 methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052190">
        <property type="entry name" value="Euk-Arch_PrmC-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875:SF1">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase small" evidence="4">
        <location>
            <begin position="34"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI12123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="225" mass="25079" checksum="4C99C4CA2307E65D" modified="2018-11-07" version="1" fragment="single">MASPRADWEGRISELINESKKHEATYSDQIGGYTVHIHPTVYSPKYFPETLWYGENLPPIVRGRSFLEVGIGSGLISLCVAASGSTVTGVDINPHAVEVARKNFEANGQKGSFLVSDVFDSVSGKFDFIFWNHPWQVDASVPKELKTEKTFDQGYRLLKRFISQAKDYLEPDGSVLLGTSAYADLKAMEAIYSANGYSHNVIQQGTRSIGKGITEEYYIIELRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCJ5</accession>
    <name>A0A367LCJ5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HORMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_0574</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCJ5"/>
    <dbReference type="STRING" id="1330021.A0A367LCJ5"/>
    <dbReference type="OrthoDB" id="1806at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045091">
        <property type="entry name" value="Mad2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842:SF11">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="8">
        <location>
            <begin position="17"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="136"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="136"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI12137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="268" mass="29618" checksum="FA7190AF70F0C96F" modified="2018-11-07" version="1">MSSKAAASSSTTSSTSKEKSKVHKLSLKGSARLVAEFRGVYPAEDFTANMASTCLVRKPPFEQDIYTCKEKKKEKKRLTCFFEVSADDQVKAYIKRIMSQLDKWMVGGKISKLVIVITDKDTGEYVERWQFDVQISSQPAPNNNNNKKSSPKPASSSANQENEDNAAPNNLLNRPPPPPPPQERSEAEIQADIAALFRQITASVTFLPQLSGDCTFNVLVYADADSDVPVEWGDSDPKEIANGEHVQLRGFSTANHRVDTLVSYRLGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCZ5</accession>
    <name>A0A367LCZ5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EVE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_0494</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCZ5"/>
    <dbReference type="STRING" id="1330021.A0A367LCZ5"/>
    <dbReference type="OrthoDB" id="41445at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd21133">
        <property type="entry name" value="EVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.590.10">
        <property type="entry name" value="ph1033 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052181">
        <property type="entry name" value="5hmC_binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002740">
        <property type="entry name" value="EVE_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047197">
        <property type="entry name" value="THYN1-like_EVE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14087">
        <property type="entry name" value="THYMOCYTE NUCLEAR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14087:SF7">
        <property type="entry name" value="THYMOCYTE NUCLEAR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01878">
        <property type="entry name" value="EVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EVE" evidence="4">
        <location>
            <begin position="118"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI12281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="251" mass="28293" checksum="F2B4D39F26AB69E2" modified="2018-11-07" version="1">MMPRKRKTADKSQESAPKRRRSSRQASKEEQKDYEDVPAAAEPNSAVNPEAPRHDGEWYWLMKAEPEPRFENGVDVSFSIDDLRAKTEPEGWDGIRAYAGASFGNINSSVTRKGNDVSARNNLRKMNVHDKSFFYHSNCKEPGIVGIMEIVKEFSPDETALIPGAPYYDPASTKENPRWSLVHVEFRRKLAVPIPLRELRELGHPGGVLENMQMLKQSRLSVSRVSESEWAALCRLADEKASEAGLEHVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LD24</accession>
    <name>A0A367LD24_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_0066</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LD24"/>
    <dbReference type="STRING" id="1330021.A0A367LD24"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="8">
        <location>
            <begin position="103"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="255"/>
            <end position="258"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI12320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="587" mass="64577" checksum="31A53FBA069F0CAE" modified="2018-11-07" version="1">MTVNGKASWQGVAEVRHSPSPSPCPSLMKTHVQVQRVQKDRAAAIPSKWVIPPSKLDEMKRSTTRMVDLLPSLLPHHELQITDLDATTLGQKLGQGQLSCLQVAEAYCHQAAVAQQLSNCLSDIFFVEALERARELDRIREATGEPVGPLHGVPVSIKDHIDVEGRRSFAGFICNASQPVRGSDALVVEILRKAGAVLYAKTTNPQTLMVLETVSNLHGRTVNPWNSSLGCGGSSGGEGALLALHGSALGVGSDIGGSVRVPAAFNGVYGFKPSSGRLPSSGFECSMMGFESVAGTFGPLGRSVEDLDLFMRLVLAAEPWLREPMLAMPWRSQTELLRREKLRIGLMAWDGVVMPHPYITRVLADVRVKLERAGHEVIDFEPHDHKKAWDEILLPLYFCDGAAGIKRALAAGNEPILPSARRLVEDPAVRVRSVEENWELNVARDTYRAEYLEKWTATANQTKSGNIMDVLICPPCPLQSTPHDVKPWWGYTAIWNLLDYPAGVIPAGKVLATDAYPEGYQPVNELDKENMELYDNGLYLGMPVAIQLVGRRHDDERVMGAMQIVDNVLRGLVESARRSRWVLEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LD40</accession>
    <name>A0A367LD40_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Gamma-glutamyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_1109</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LD40"/>
    <dbReference type="STRING" id="1330021.A0A367LD40"/>
    <dbReference type="OrthoDB" id="2015213at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052896">
        <property type="entry name" value="GGT-like_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43881">
        <property type="entry name" value="GAMMA-GLUTAMYLTRANSPEPTIDASE (AFU_ORTHOLOGUE AFUA_4G13580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43881:SF1">
        <property type="entry name" value="GAMMA-GLUTAMYLTRANSPEPTIDASE (AFU_ORTHOLOGUE AFUA_4G13580)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI12335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="599" mass="63753" checksum="ED7A46CE5ABFCD7F" modified="2018-11-07" version="1">MPLTSSSLYPGESSRDLYKFPSRRSVVHSTSGIVACSQPLAAKCGLEVLRAGGNAAVAAGLNVTEPASTGIGGDMFILFWNAATGKVSAINGSGRAGAECTLEAIRRDLGIPDGVGGGIPATSAHAVTVPGAAAGWIDTVERLGSGKLSLASIMGPAIELAERGFPVTEAEGMFWASAESRLRQASPNYAEMLKDDPSAEGGVRAPRPGEVMRNPNLAQTFRALVTEGKKGFYTGRVADEIVKVVRNKGGRLSLDDLRRHLDMGSESVEPISLRFTGQGLGAENGIEIWEHPPNGQGVVALIALGIIQQLERQGKIPIFGPDDFNTTPYIHAIIEALRLAFTDGRWFVTDPDFMKLSVNDLISDTYLGQRARLFDPSQAAARISHGDPPSWTSPALQSCDTVYFAVTDAHGNAASFINSNYDGFGTGIVPRGCGFTLHNRGSNFSLDARHPNRFAARKRPYHTIIPAAVTNLDDGSLHSVFGVMGGFMQPQGHVQVLLGQIVGRLNPQQALDAPRVRISQATIPSQEEPEWDVSVESGMPAATIKGLRRLGHRVTVVEGSERGMFGRGQIIRYTVDTVDGTPIWSAGSDMRADGAAYPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LD98</accession>
    <name>A0A367LD98_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LD98"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="69" mass="7656" checksum="3D783BC1DAB9DD54" modified="2018-11-07" version="1">MPMETTSTMPGATHNLAFRPDPRQRRLESCHGAHLNNTPSRNPKGAHVSGARGTIRIAWMYKMPDQSSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDB2</accession>
    <name>A0A367LDB2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDB2"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="75" mass="8047" checksum="1E49F041760E3751" modified="2018-11-07" version="1">MDGGKEGQKKISIKCECILLPTGLGRLKKKYLLTRKGAEKQDDNDDDDEEEEWSGVEGGVEGGVEGGPAIRSPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDB5</accession>
    <name>A0A367LDB5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_1123</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDB5"/>
    <dbReference type="STRING" id="1330021.A0A367LDB5"/>
    <dbReference type="OrthoDB" id="5571754at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3370:FF:000001">
        <property type="entry name" value="40S ribosomal protein S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00545">
        <property type="entry name" value="Ribosomal_eS24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053709">
        <property type="entry name" value="eRP_eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001976">
        <property type="entry name" value="Ribosomal_eS24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018098">
        <property type="entry name" value="Ribosomal_eS24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10496">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01282">
        <property type="entry name" value="Ribosomal_S24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00529">
        <property type="entry name" value="RIBOSOMAL_S24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="100"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI12401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="136" mass="15489" checksum="FA38991E4DFA3D43" modified="2018-11-07" version="1">MADNDGPVTLRTRKFIRNPLLGRKQMVLDVLHPSRANVSKEELREKLGGMYKAQKDQVQVFGLRTQYGGGKTTGFALIYDSPEAMKKFEPAYRLVRVGMATKPERASRQQRKQRKNRQKTLRGTAKVKGAKAKKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LF11</accession>
    <name>A0A367LF11_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">threonine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Threonyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_0461</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LF11"/>
    <dbReference type="STRING" id="1330021.A0A367LF11"/>
    <dbReference type="OrthoDB" id="5423599at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000039">
        <property type="entry name" value="Threonyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF50">
        <property type="entry name" value="THREONINE--TRNA LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="70"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI13006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="483" mass="54676" checksum="68A1BAFF1920FF04" modified="2018-11-07" version="1">MLLQCSRRSQAAMRAVPRCCSPTLPRFSHAKREVKGGKRPEQQPDHRSLGLQQELFINSVYSPGSPIFLPHGTRVFNRLVNFLRKLYVFFGFDEVITPTMYKSSLWAKSGHLQNYRNDMYAVKGNGSKGQEDETEGEYGLKPMNCPGHCLIFKSKLRSYRDLPIRYADFSPLHRNEISGALSGLTRSRRFHQDDGHIFCRPCQVKDEIKKTLDFVEAVFSVLQVGKGYRCVLSTRPAEHYIGTEDEWSRAEDHLKLALEASAMDWTVDEGQGAFYGPKIDIVVTDPSGKEHQTATIQLDFQLPKRFELEYQAPAPEQEATGELASDPELLAKFGPVMPVMIHRAVLGSVERLMALFIEKNNGKWPFWLNPRQAIVLTINDTPSIVNWAKKVRDYLVGVPHLEDCPFPESLPALTARLKDFAVDVDATSRPLGAKKRDAIEKGYGMVLLVGEQEVQDKQVSLNRKLFTPAEVRDLMCSQVESFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFF1</accession>
    <name>A0A367LFF1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0428</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFF1"/>
    <dbReference type="OrthoDB" id="10588850at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="284" mass="32602" checksum="302436483B9DC9B3" modified="2018-11-07" version="1">MSNGFTASYSGGGPSYDSSCPSGYSYSTLISGSLDASLGGEGDDRRYYHPHYHSHLQRQHRKHPSCKRSECSVRESGAAAARRRSSDLDKRKEKERRSSGAETTRRSHHSERRLSSDTKRRHSRNSSELKRGHRRHSLDAKRAHHRHRHAHHRHGRHRHHHKHRHDHGKEVDTPSTSFFRTGPAVISDKEDGGDDDDNNNNNIKNDNDDDEEPSSCFGRRRTASPPSLDEENHVGCFGRPAKEGGVEDKDKKVKKEKKRKKSLPFHRVKNDGQKTTWRFLSWFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFK2</accession>
    <name>A0A367LFK2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_0855</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFK2"/>
    <dbReference type="OrthoDB" id="5130140at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI13198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="308" mass="33745" checksum="1E755902591B1B32" modified="2018-11-07" version="1">MAIHPTDVATQGMDVHGLRFLNDEWNDSISNGEVFTVRWNQSLTKVGSGLGVFQVTYPKDGVVVYELVSNLTDAIENDGATCKWMPQNLEKKNVYAMWLTSADALHPNWTLSPPWVPKEAPNGHDGSKSGSQGTPWAAPFLIPVVCLLGLYALSLTGYLVYRRRKKTKMEKSLASPDSSRHCNFVNLPISSQALNGDEARLDKPVVVGMVNTDHVVDGDGLDRLAGITCPRATHIDYDEDDDEDDSHRSTARSRGIRIVTNSGPRSEAEERLLVTPVLSAGSTVSSSTQQTPVGRNFSRPVQIPRNFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFL8</accession>
    <name>A0A367LFL8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP synthase subunit g</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_0287</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase g subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFL8"/>
    <dbReference type="STRING" id="1330021.A0A367LFL8"/>
    <dbReference type="OrthoDB" id="437at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006808">
        <property type="entry name" value="ATP_synth_F0_gsu_mt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04718">
        <property type="entry name" value="ATP-synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI13220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="199" mass="21405" checksum="94B2D80FCA2545EB" modified="2018-11-07" version="1">MASSLTRPMLRATRLPLPTRTRLQSSSASTAAASAGKMAKEAVPDKARDYQARAHEGLSRVTRAAAPAIAGAVRGAVGTLGRIGGRTGRLIAFAEKQTPFVVYYSKVGLEMSKIIFRGQNMTPPSLATFQTYYQNLWRAVQSGSFFPSPQVILQQMRSISTTQLVAGGVIAAECLGFFTVGEILGRFKLIGYRGEAVHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFQ9</accession>
    <name>A0A367LFQ9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_0828</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFQ9"/>
    <dbReference type="STRING" id="1330021.A0A367LFQ9"/>
    <dbReference type="OrthoDB" id="5416589at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000171">
        <property type="term" value="F:ribonuclease MRP activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034965">
        <property type="term" value="P:intronic box C/D snoRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000294">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, RNase MRP-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="entry name" value="Alba-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014612">
        <property type="entry name" value="Pop7/Rpp20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020241">
        <property type="entry name" value="RNase_P/MRP_Pop7_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28256">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28256:SF1">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12328">
        <property type="entry name" value="Rpp20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82704">
        <property type="entry name" value="AlbA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI13227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="171" mass="18311" checksum="D5A273364E0898D3" modified="2018-11-07" version="1">MTATTTSPRRHPPNEKLPPIRDGAKVRKRPLLRRQVGSSSKKPVIYVSSSTPFMSVVNRVQKLLDKSLRDASAATAAPRNASLSARVKALGQDDAAASASRTTVTISGAGKAIEKTLSVAGWFENKGDCVVEVRSGTVGAIDDVLPAEGEDGDDETRVRRLSYLEVVVRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LG03</accession>
    <name>A0A367LG03_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L249_0794</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LG03"/>
    <dbReference type="STRING" id="1330021.A0A367LG03"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002974">
        <property type="entry name" value="Cyt_P450_E_CYP52_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002402">
        <property type="entry name" value="Cyt_P450_E_grp-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF17">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00464">
        <property type="entry name" value="EP450II"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01239">
        <property type="entry name" value="EP450IICYP52"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="5"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="468"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602402-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCI13350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="523" mass="58940" checksum="EFA8E13469896AF3" modified="2018-11-07" version="1">MLREIAYLVTSLGSGGTLVFAFAIPRARPYLRSAWLVLALGAVLMVACSRYRLLRQMRLRGTLPAAVYPHREPILGIDWMRLLSQANQQNRLLETSHQLFTQSVATTFWANGFGTWSLMTCDPQNFKAILSDQSDAWDVSDTRAKSLAPAVGKHSILAVNGPEWSQARAVIRPIFSRHPIAELACIEHHVDNFLARLKPAGAKVDLKELIYMFTLDTSTDFMFGHSTHLLDQPSARNIEFNAAFVHAVHISTTTGRFGRLAPLMRGSKFHASVATCRAFVDRYVTEALEKNKHEDSSYVFIRQMIELGATHEQTTDQLLTLMLVGHDTSACVMCFMFWMLARRPGVVRAIRHEVLQLGEGRPTWQQVKNLRYLNNVYMEALRLWAPTAFNSRIARKDTVLPKGGGPDHQSPLFVPKGTECSFSLHSLHRLKDTFGDDAEEFRPERWESPRSRPTNWEYQPFGIGPRICPGQQFASILILYLTVRFFQEFESIEARDDGPMVLKLGASLELGTACWVALTSAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LG29</accession>
    <name>A0A367LG29_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_1012</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LG29"/>
    <dbReference type="STRING" id="1330021.A0A367LG29"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF89">
        <property type="entry name" value="ALPHA-1,2-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="55"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="421"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="493"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="579"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="378"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI13371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="590" mass="65668" checksum="E027C9EAA801AED1" modified="2018-11-07" version="1">MLNLRRLGALAVLAALAFILTLLLGRGGPRMTTAGSVRYVASSFDWSRVKPSHPVARVRRPPTGRPKAFPRVQAKKSSSGRDDVAKARRDAVKRAFVKSWEAYKAHAWGKDELMPLSGKGRQTFSGWAAQLVDALDTLWIMGLRDDFRLAVREVAVLDWSKTHDGKPLDVFEVTIRHLGGLLAAYDLSGEAVLLSKAVELGNMLYAAFDTPNRLPARWLDHARVRTGQQKADASTPTAAAGSLCLELTRLTQLTGDARYYDAGERVKQFFRRAQTDTKVPGLWPRVVDLRDETADGDVFTLGAGADSLYEYLPKMHALLGGLDPQYEDMATRALDAAHERLLFRPATPKEDDRVLMAGRLAWDDGRATLTPEMQHLTCFAGGTYALAGRLLSRNDYVALGSRLAAGCVWAYDSFATNIMPEISELVACDRLEGPCRLGNDDDENNNKDDDDDDAAAASFITASSAARALKGHREKLPAGFVRVRDARYLLRPEAVESVFYLWRITGRQVWRDAAWRMWEGIVRETETELAFASVDDVRVRGSAKADSMETFWLSETTKYFYLIFEDEGVIDLDQWVLNTEAHPLKRPRPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LG59</accession>
    <name>A0A367LG59_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_0656</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LG59"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI13377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="62" mass="7051" checksum="AB896F6DD42E0E70" modified="2018-11-07" version="1">MSNCLPSPRPRGGFLSLPVMAYKSFLRKTPATYHLSIQRTKNAELPISVGLSRFWVTYNLHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGN9</accession>
    <name>A0A367LGN9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5628</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGN9"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI13580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="55" mass="6685" checksum="9D4D9FDCCD174E43" modified="2018-11-07" version="1" fragment="single">EEEEESRNSLKEEIKEELEAGEVFVLRRYFSRYFKVPTYSTLTYLYKIGDLEEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LH31</accession>
    <name>A0A367LH31_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_7955</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LH31"/>
    <dbReference type="STRING" id="1330021.A0A367LH31"/>
    <dbReference type="OrthoDB" id="10248446at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02413">
        <property type="entry name" value="KH-II_40S_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1140.32:FF:000004">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.20:FF:000006">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="entry name" value="Ribosomal protein S3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057258">
        <property type="entry name" value="Ribosomal_uS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_uS3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_uS3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005703">
        <property type="entry name" value="Ribosomal_uS3_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003219">
        <property type="entry name" value="PRK04191.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01008">
        <property type="entry name" value="uS3_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760:SF32">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="Prokaryotic type KH domain (KH-domain type II)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="Ribosomal protein S3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="9">
        <location>
            <begin position="24"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="217"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="232"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="249"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI13709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="260" mass="28737" checksum="604EF7D9A3575348" modified="2018-11-07" version="1">MAHSGTQLSKRRKFVADGVFYAELNEFFQRELAEEGYSGVEVRVTPTVTDIIIRATHTQEVLGEQGRRIRELTSLIQKRFKFPENSVSLYAAKVQNRGLSAVAQCESLRYKLLNGLAVRRACYGVLRFIMESGAKGCEVVVSGKLRAARAKSMKFTDGFMIHSGQPAKDFIDSATRHVLLRQGVLGIKVKIMRGSDPEGKAGPQKSLPDAVTIIEPKEEQTVTQPMSQDYGAKAAQAQASQDARVAEQEGVEEEEMAEQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHD9</accession>
    <name>A0A367LHD9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_8060</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHD9"/>
    <dbReference type="STRING" id="1330021.A0A367LHD9"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="58"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI13838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="491" mass="52771" checksum="84BD59182323C370" modified="2018-11-07" version="1">MATPLLHSNSAIVMLFFYTLFSLLGFAYGLDLLTPLRRLLSPSSRIDGNAPRWSEYPAPPSPAPVVHPATVSDVQITIRWAATHNIPFLVYNGGNGWAANLKLDHHNGFFFYLALDLLRSVTFNPDKTVATIGAGALTADVVHAGSDAGSLVATATCDCVGFLGALLGGGASHLTGQYGLLVDTVLSMDVVLSDGSLRTVTGSSDPDLWWALRGAGPNFGVVVEVEVAAHPDAPLTAWQGSLVFSPDKLGSVLDAVAGLTTSLPPPAALALLYAAHDGSPAVIVDLFFHGSAFADEAAECFASLLTLGPVSGSTSMKQRPWKAWNAPSAFACRKGGRKPTWGAGLSRFDPVVFAQVYDVWHDVAQQPGAANSSMLLNWFPMDKARSLPLTSSAVPFRHEVGLFPTLTIAYEDAVFDEAAVQYGRRARALWQAADGLGDHHMTVMPERYINNAFGDEPLEVVYGYALDRLRRLKKRYDPTCRFSRWFPLLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHG5</accession>
    <name>A0A367LHG5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_8260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHG5"/>
    <dbReference type="STRING" id="1330021.A0A367LHG5"/>
    <dbReference type="OrthoDB" id="3358869at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042332">
        <property type="entry name" value="Hsk3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013183">
        <property type="entry name" value="Hsk3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28289">
        <property type="entry name" value="DASH COMPLEX SUBUNIT HSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28289:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT HSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08227">
        <property type="entry name" value="DASH_Hsk3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI13865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="59" mass="6407" checksum="6FDC7A3BF53A9A1F" modified="2018-11-07" version="1" fragment="single">THLHSQLAQLSANLADTENLLRMTSVQAEAMRGLGSWHAGLFMAASKVLGEESVREEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LI11</accession>
    <name>A0A367LI11_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mannan endo-1,6-alpha-mannosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI14064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LI11"/>
    <dbReference type="STRING" id="1330021.A0A367LI11"/>
    <dbReference type="OrthoDB" id="9984024at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053169">
        <property type="entry name" value="MUG_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791:SF1">
        <property type="entry name" value="ENDO MANNANASE, GH76 FAMILY (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 191 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016613459" description="Mannan endo-1,6-alpha-mannosidase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="403" mass="43795" checksum="8536923D49A6A891" modified="2018-11-07" version="1">MLLQLGAALALAATTSSTSTTAALAASSRATLINQTSEAIKSLNNRFYSQQTGVYDDAWWNSANAITTMADFAAIDLAAANAINVGGYLRNTFVQAQKTDVRTVKAMKNGRVSSTYCLDNRGGCMAKREFAKRGFDDFINEFYDDEGWWALAWIRAYDVSGDRQYLEAAASLFKDMQTGTGTPCGGGIFWNKQRKYVNSIANQLYLAVAASLANRMPKQPVDYLSLARAQWTWFEKSGMINKNGLVNDGLDGSCKNNGLPTWTYNQGVIIGALVEMSRASGERWLVDRASAFADAALSSPLKGKDGILHEVDNCETKPGNCGKDGQQFKGIFIRNLRYLYLAQQKPNPKYRDFILRNARSIWDKDRAAGASLLGPAWAGPYIAATGPSQSSALDALVAAVAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIL2</accession>
    <name>A0A367LIL2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_6156</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DOCK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LIL2"/>
    <dbReference type="OrthoDB" id="18896at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08679">
        <property type="entry name" value="C2_DOCK180_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11684">
        <property type="entry name" value="DHR2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.350">
        <property type="entry name" value="Dedicator of cytokinesis N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027007">
        <property type="entry name" value="C2_DOCK-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026791">
        <property type="entry name" value="DOCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043161">
        <property type="entry name" value="DOCK_C_lobe_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032376">
        <property type="entry name" value="DOCK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042455">
        <property type="entry name" value="DOCK_N_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027357">
        <property type="entry name" value="DOCKER_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056372">
        <property type="entry name" value="TPR_DOCK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653">
        <property type="entry name" value="DEDICATOR OF CYTOKINESIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45653:SF10">
        <property type="entry name" value="MYOBLAST CITY, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14429">
        <property type="entry name" value="DOCK-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16172">
        <property type="entry name" value="DOCK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23554">
        <property type="entry name" value="TPR_DOCK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51650">
        <property type="entry name" value="C2_DOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51651">
        <property type="entry name" value="DOCKER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="8">
        <location>
            <begin position="89"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="C2 DOCK-type" evidence="9">
        <location>
            <begin position="698"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="domain" description="DOCKER" evidence="10">
        <location>
            <begin position="1529"/>
            <end position="1935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="170"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="233"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="489"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1930"/>
            <end position="1969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1989"/>
            <end position="2027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2039"/>
            <end position="2117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="170"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="197"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="501"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="511"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1996"/>
            <end position="2008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2071"/>
            <end position="2083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="2102"/>
            <end position="2111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI14268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2117" mass="234443" checksum="6CDE636FA916B592" modified="2018-11-07" version="1">MERGETWAGSHNYDDDDDDDDDGHLRHRALDVFRYPPNGCAPSPGLADQTASFRRLEGLALAIQPSAHGIEALLGGAHTVNSMPWQPLPRIAFAVAIHPFTAESPADLPLEIGDELYIIEETPDGNWLRGYLVAPPSILAGLTSVKGQTLEARVFSGIFPRSCVEVRELLGEPDPGRDGNGERGGNGAVDARPASDSAKSGFTNGNSPTKDVANNNSAATSLARDPLSELPNGILGKLSVPQKRDSNAPRPAAPVPMLKIGDETPTSASEPLIDEIASCLREWHSKNLHELLLSRRYAELDELSRLIARLNIHRQQLLYNVLTAHEYEQLRERTVWDLVTVSKLCGGQVIVRDPAARGRVMTGDDSAVEITRLQSQMSLLDEPPQPVTELSSLHHLMLEVKGFAGTSAEETSLMIYLVSKSQNGDVSSLSECFHVEIPPGGTIGSLAQNSSTRTLFIDLSPQDVGDAPPADSELYLVVKALAPQQIAFPAPLSRSGTHTDSSGHSRDHSKSLSTGSTNRNSRRSLMWGGKSNRQTLSRGYSMPKMEPVSEQQEETPALCEVESREGHHPPSSACSTNASVAGTTQTVQRMVGVGVLRLSPFMKQANEVEQVVNIWSPASARSSSDKETKAVWDPLIREVLEKPNGQFEKSRRGERLQVGLQTFTHQDADALIKTTPTLLSGVTTTSRIGFSGAPSKPRSDIYLTINSATLTRQHLLSRYGASAVALPSSFQGANLQLTLEIRGPSGQRFENCIFNSSNNEALTTFRSAATERGEPWNHTLRLHLSPNDVPTAHAVMFLSDLPNHPFAVAHMPLWDQEAFLRDGRHALLLYKLDENTVTAQAGPTGKGGYLSLPWAVRGKDQHSPDVTGPLAALLVDTFLCSTKFSQDRVILGLLKWRELPSTEDLASVLKQLIFVPEIEVVKLLSDVFDGLFSILVEHSGNDELEDLIFTALVRVLGIVHDRRFNLGPLVDQYAETQFRYPFATTSLVRSFTRLLENPTEPETARKLRATFKVVRQILKFISHARGQMKAKEAVIGITSSPQGFTRQLRSIFKALDAMMRNPSPVLVGSQTLAVQHFHTWLPELAGLLTTEEILHVAIDFMDSCTNVKGKLILYKLVLIVNYSKLHLFSQTEQKAALCANTVRWIAPHWGHTDEVSDQWRDQIRLCCSVIASQVDQLGPEIPDHLPRIIDSYLSIQSSPRKPRDRLSLLFPTSYPFPSKPISEELEFDEALAELSAVLSAISTSSMGMQLELAEGDLTIILENLLRVHMSILTGDAFPPGWLSVYIHHHKSTLRTLTNLAGILLESFLPDPDEAESFNTELWKLFFTTLLKLVGSPSLALETFPEQKRRAVWKIAGDVREHGAELLRDTWEAVGWETTPDERGRYGLPRIGGYQVQYVPTLVGPVVELCLSVHEELRRMAVEVLQTMIVSEWTLSEDLTVVQTEMVDCLDRFFKSKPVTESMLQKLFVGELLERFEPLADTVDEPLYQAVRDLVSTLHEFLDLLVAVHSGDGCNEASAIINQLRLMEFLRDMQKEEIFIRYVHQLAAFQASSRNPGEAGLALRLHADLYPWDPTRQTPALVEPEFPAQTLFERKERIYFEMVKLFEEGESWSNALAAYKELQAQYESNVFDFAKLARTERAIATIYEKIAKCDKITPRYFRVVYKGLGFPSSIRDKEFVYEGSLTERASAFADRIQEQFPAAKIVATGGDVNEVEGQFLVISTIVPHRDPAHQVFQRARVPNVVRDYLLCSHPQSFSITKKRNTTGPVEGHYAEKTVLTTSEPFPTLLRRSEIVESHHLRLTAHETGLERISRKTQELAALERRLADGEGENVQQILDAVTIAVNPLSEHSAVCYRKLIPQPRQEEGEDVEEAELEPEETALRMALIDHALMIKKCLATFSRSTNELLCRKHEELNQHFESTFEPEIATFAPPPLPRVATPTPSTAFRGSFPSEKRPQWPKVASPLNGGAKAEEAAVVHRVSMRHRGARLSFLGGRKQEADDAPETEKANGGGGAETPNPPRLSFSKASGLRNSLFRSQSMSEGNDEQMTVGRGRVSSSAGKESLDSGVMTDEKGLDKEEPAISKRGSMRKRLSKLNVKLGMKGGKAGWGMGSLNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIN2</accession>
    <name>A0A367LIN2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_5997</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIN2"/>
    <dbReference type="OrthoDB" id="4931002at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI14237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="509" mass="57317" checksum="890D52E1487BE53F" modified="2018-11-07" version="1" fragment="single">HPAGGPRRPARGRRTSQRLYVTAAVRGGYGYGYGYGYGYGYGYGCTGRTGQQVKQGVPSSAIQSASVRSGLQRQQQQQQQRQQRQQRQQTQKDYLITGCQEGGRTRGPRQQTSRPSSSSFLRQGSQRPIPRSFFSTFAADTATATATANALVATVPLLLLLSLSNALFHPIFSAAFFVLWFSVLFFPPSSSYGRPYDLQRRQEQGQDQEQGQDQEQGQDQEQGQDQEQGQDQEQGQDQDQDQERDRQRNTGTSQEQQSQQPSRQPLQQEQRQQTNVPDRRVDWLPFFVAPPCLRQIQVLTEDLPWPAAKTALLRYYGAFNQIRTVGFYDKLRRHEARRPKTKDTIDWLEKHAFLCRKIGSGYGPGPGPGPGPGPDESTEHSYGLFQALPKEIQVQLYDQLGQRPSSSPYGILRLFLPLSSFLSFLRLSAGLRCTRPEGLGGSRDAGSAAAGPRPPYVTEAVRHSGCTRRLRLRLRLRLRLRLWLRLYGPYGPTGQARRAFFSNTISLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIQ7</accession>
    <name>A0A367LIQ7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Nuclear envelope protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L249_6086</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NDC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIQ7"/>
    <dbReference type="STRING" id="1330021.A0A367LIQ7"/>
    <dbReference type="OrthoDB" id="67850at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070762">
        <property type="term" value="C:nuclear pore transmembrane ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106166">
        <property type="term" value="F:spindle pole body-nuclear membrane anchor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070631">
        <property type="term" value="P:spindle pole body localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019049">
        <property type="entry name" value="Nucleoporin_prot_Ndc1/Nup"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13269">
        <property type="entry name" value="NUCLEOPORIN NDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13269:SF6">
        <property type="entry name" value="NUCLEOPORIN NDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09531">
        <property type="entry name" value="Ndc1_Nup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="10" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="261"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="614"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="614"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="635"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="651"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCI14299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="696" mass="77893" checksum="D4805320C89FBF89" modified="2018-11-07" version="1">MAGTPSRRAPYKDTLQPALHRRFSSTATLLLAASYLEALLLTPWTSFLWSWFPFGPCGIRTGVIFTCGLAILILRIANYHVGFRTTASGIHSLGFILTSPRTYETGFWYGLSAWVFCPVFLASMPSSSNLRWITYWSGDRARLNERPLMLACYSIMCALWQTIRHYRLDLDRVEFGLPRAKAEGRDVDQASSSMPLQAFLSQVPRVLSECALQASLTLLLTIVFYFACVRSFAWSWTMTFLRPFYNLPQSRIPPPTWPVDLFLMARCIYAGTLLFAVWSTGNTAFSLFMVKEPLKNGKPLTSESKDPNGSLLNGLKSKKPSIQSFAMWELALISKDFDARRQAIFRDIDRKDGPMWTQICAVCMELLLSIEQRVDQFERPETTAVTPPAEVPVRQRVSAPLRDEPIMNQTNRSYGLIGGVEKVWDQMGRAPGSTPASELSPLAKKTWKDAKDRILSKEQQEALRPEHIRSGLSHWAAGFVDVPGLGCLLRQDAGTQLAAVVLGTPYAEPTVYINAVEALCQLAVHSLAEDEFGVVQRDVASVVRIMTAVTGKVEGLKRRFPNHWTFAGRTPESPAVDAITEALRTGLDRLVTTFEPYSSDLGLSRGDVRLAKEAATAPRREAKDTVKGTEKRKSMMMMATATTATASKPRRVPERERERERNRERERELRGERGVVALVWRGRMALADAVVVATRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIU9</accession>
    <name>A0A367LIU9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PPPDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_5941</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIU9"/>
    <dbReference type="STRING" id="1330021.A0A367LIU9"/>
    <dbReference type="OrthoDB" id="412286at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101005">
        <property type="term" value="F:deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF80">
        <property type="entry name" value="IP06716P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="5">
        <location>
            <begin position="23"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="172"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI14330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="236" mass="25505" checksum="713F210A3B6501D0" modified="2018-11-07" version="1">MPVRDDVAPRASSHRSTLSLQKTQITIHVYDLLPPGRVSSVLWTIGASLLHSGVVINGREYAYGGHDRRGVTGVYWTKPKAEPPGGIFRCEIIHGFTLATATEIDAVLHTASDEFLGTSYNLLTRNCNHFTSYLCQRLTGNPGPGWLNRAASIGVALPCVVPREWIDPPEYETADGELLDNGVDPSDEQAHMLSHPRPRLLAENSDEGGGKRSTAVLDSSGRRIPAAERAPSDAGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIV1</accession>
    <name>A0A367LIV1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_6008</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIV1"/>
    <dbReference type="STRING" id="1330021.A0A367LIV1"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="138" mass="15933" checksum="3D5A20EDC1337B90" modified="2018-11-07" version="1" fragment="single">TRYKDIRTFSRKKSEFSAFLTNLKDKIRINKATFRDEEDRIGFLFRSLEGKACKTLKTQYDSIERPFSGLAEIIYLLTKTKDNSLSYEDFCGYVKDSAVKRLDTELVLPNNLPALAKYSLSILLPKTLLLNRQIDPAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIX8</accession>
    <name>A0A367LIX8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">40S ribosomal protein S23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_6000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIX8"/>
    <dbReference type="STRING" id="1330021.A0A367LIX8"/>
    <dbReference type="OrthoDB" id="1713912at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03367">
        <property type="entry name" value="Ribosomal_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000007">
        <property type="entry name" value="40S ribosomal protein S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005680">
        <property type="entry name" value="Ribosomal_uS12_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003254">
        <property type="entry name" value="PRK04211.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00982">
        <property type="entry name" value="uS12_E_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002133">
        <property type="entry name" value="Ribosomal_S12/S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI14360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="15779" checksum="5AD05A1DCEEB632E" modified="2018-11-07" version="1">MAGGKPRGLNAARKLRTNRKDQKWADLHFKKRALGTAFKSSPFGGSSHAKGIVLEKVGVEAKQPNSAIRKCVRVQLIKNGKKVTAFVPNDGCLNFVDENDEVLLAGFGRKGKAKGDIPGVRFKVVKVSGVGLLALWKEKKEKPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJ25</accession>
    <name>A0A367LJ25_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Guanylate kinase</fullName>
            <ecNumber evidence="2">2.7.4.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">GMP kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_6141</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the guanylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2"/>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJ25"/>
    <dbReference type="STRING" id="1330021.A0A367LJ25"/>
    <dbReference type="OrthoDB" id="6334211at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:GMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000776">
        <property type="entry name" value="Guanylate kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020590">
        <property type="entry name" value="Guanylate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117:SF13">
        <property type="entry name" value="GUANYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117">
        <property type="entry name" value="GUANYLATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00856">
        <property type="entry name" value="GUANYLATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="9">
        <location>
            <begin position="8"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI14443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="193" mass="21555" checksum="39140A5FB148B86A" modified="2018-11-07" version="1" fragment="single">GPIAPSDRRPIVVSGPSGVGKGTLYHLLFDRHPDTFCLSVSHTTRGPRQGEQHGVHYHFVSMDAFEDLIAADGFVEHAQFSGNRYGTSKMTIEQQTAKGKVVLLDIEMEGVKQIKKAGIPARFVFISPPSLQVLESRLRGRGTEKEESICKRLTQARLELEYAQTQGVHDAVIVNDDLERAYKEFEDFIYQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJP8</accession>
    <name>A0A367LJP8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJP8"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="65" mass="7074" checksum="EA838C6EC741FD7A" modified="2018-11-07" version="1">MESAAAAVTLFKVGGRAQGTTLLSVGRDNYFRLGDVSGDDDDDDDDDDDDDDDDRKTIFREAEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJU9</accession>
    <name>A0A367LJU9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="10">1.3.1.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">L249_6456</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs. Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>5,6-dihydrouridine(16) in tRNA + NAD(+) = uridine(16) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53380"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:53382"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>5,6-dihydrouridine(16) in tRNA + NADP(+) = uridine(16) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53376"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:53378"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5,6-dihydrouridine(17) in tRNA + NAD(+) = uridine(17) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53372"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:53374"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>5,6-dihydrouridine(17) in tRNA + NADP(+) = uridine(17) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53368"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:53370"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Dus family. Dus1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.88" evidence="10"/>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LJU9"/>
    <dbReference type="OrthoDB" id="5563016at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF5">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(16_17) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="19">
        <location>
            <begin position="887"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="131"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="200"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="365"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="524"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="618"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="684"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="731"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1282"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="249"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="393"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="423"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="454"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="537"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="740"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="769"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="20">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="20">
        <location>
            <position position="1303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RCI14708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1303" mass="140299" checksum="723E23075FADCFC8" modified="2018-11-07" version="1" fragment="single">PARLAVAATVCLFPPLFFPDGTNLLSPRLPTSSRSFCPVNRFLSPTADSESIQEKPLHSHSFLAVREKEHTNHGRRKIYPSFATAIPDLRSDFRDFFSSPALLATVGRLAADSHKHGCTYPQQTTMLQARPSSTSGIVPPSPSHANHPYMGPGSPQSPRSPYHGAASSAYRGNAAAVQPYAFTSTPNLHQTVPRQHYSAYRAGSSSGAPGTTPPHDVASSHRNSPQLPPAGYSLSFGVGHGGSRDDSVLTTRTASPTPRSPSTLSVGSQPSSNSGAVIRNAPERYRRSGGGGFHARSQSSTLPSSIAVLHPSQPYPVQSNPRYSAPAPPGHRGLVSVSSLDDIHLRGRQHLEDARKLHRRSLHGIDASDKFGPMATDAARSDADPKSPRLVPSAVTHSRSVSSESVASTRSSQSRRSATNRSVSDSKGTPSSPVNDEASPKTDQPRLVNIPPRGSSSDATKRTLSPSPLSKPATMATTEDEATAVKLDSPAAKQLAAINQKGGKTKSKASRLRRAFSFGSAADFRKAAGGDDDGAEKEESAAKLHKEPTPEEAYDAEQARIAEAQEAAGIGSSIYGGRFFGSTDNISISSTASSASVMIRKMGRGMKKGTRSLVGLFRPKSVTGIPPPDAPPSESSQAAVSMITVEAEAQRVNVTADPAQANGGTGFPHLERNSLDAARISDMAPERLDSSGRDQAAARKSIVGGDKERAEALAAVRKGILKRERSLGRIVAAATTDRQPAAGSASPSARPAESSPELALPNILGVADSPNSTAPSTPNDESQGHKRTGSISIGNEDYFVSALRLRQETRSPPATPQGAAKRSATFSPRIVFYDTWPSQEYDRRGNIATCNRLTPMLAQQIKEELNTFKMLHGRAFYESIGSPKFVVAPMVDQSEFAWRMLTRSLMPEAERGRLLAYTPMLHARLFATDDKYRRTHFQPTTRRDKDKEEEAWLDGNAALGDRPLFVQFCANEPDTLLKAAKLVAPYCDAVDLNLGCPQGIARKGRYGAFLQEDQDLIFRLIDKLHRELDVPVTAKIRILDDREETLAYARNVLSAGASILTVHGRTRQQKSHLTGVADWDTLRFLREKLPPETVIFANGNILQPGDVERCLSETGADAVMSAEGNLSDPAIFANGVVASDVDARREYWYGLKDGHGEGWRVDAIMRRYLDILHVYALGSSTPPRPRAPKAFRASGSSDMQVYEAVLREVETKVAQGIAEYAGSGGSSFDHDLALLFPPPASSSSMHADEEASSSAPTLRRCRRPWWVAQPIVRPLPAEALEKGAVTFKKEKRKKKDAQKGDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKA6</accession>
    <name>A0A367LKA6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_6892</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="1"/>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKA6"/>
    <dbReference type="STRING" id="1330021.A0A367LKA6"/>
    <dbReference type="OrthoDB" id="41238at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002307">
        <property type="entry name" value="Tyr-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023617">
        <property type="entry name" value="Tyr-tRNA-ligase_arc/euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050489">
        <property type="entry name" value="Tyr-tRNA_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264:SF4">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264">
        <property type="entry name" value="TYROSINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006588">
        <property type="entry name" value="TyrRS_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01040">
        <property type="entry name" value="TRNASYNTHTYR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 9" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00033323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI14692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="375" mass="41630" checksum="C73BA0645D1BEA6C" modified="2018-11-07" version="1">MDASLGAEERYSLITRRLELQNGWASQKLTSLVAQGKAIRYLWSTTPTGKPHLGYLIPLIKFADFIRAGGEVTIEFLDTYGLLINYRFPWDQVCHRSRYYRWLISAALEAVGVPMSRMRLVDASSYQGTSDFMLDFWKLCTLCSQQDVRDTGAEVGASTMLSPLLTPLLQELADEYLGIDVEFGGLDQRGIFNLGEQFLPELGYEKRVHVMNQMLPSLTGGKMSSSHPDHTKLTLLDDEATIERKVAGSSCPAGTAEGNGMLPIVEHILMPISELHVRDRGRSPMVAHGAAEGTLFSVDVGRGPSPDPASRRDYCTYQDLQRDYLRGVMEPEALKAAVARAVHQVLAPIRDAYAGNEAWREADRMGYPEDWPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKB9</accession>
    <name>A0A367LKB9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_7040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKB9"/>
    <dbReference type="STRING" id="1330021.A0A367LKB9"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02183">
        <property type="entry name" value="GH16_fungal_CRH1_transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF68">
        <property type="entry name" value="GLYCOSIDASE CRH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="100"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI14871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="472" mass="51067" checksum="1D8E96E86F78CB7B" modified="2018-11-07" version="1">MAGEKDNLTALLASSSSSSTPPPPLLLLLLYSPIFIFIFIFILILILILILIRRQIIVSLPRPHNKMRSHHLTTTTLSLLLLSHPNKASGQTWSRCNPLISSQCPPNTALSMAINVDFRHGAVNSFVPSGSPTYDDQQGVSFTVARGGEAPQLTSVFYIMYGRVEITMKAAPGPGIVSSLVLESDVLDEIDIEWLGSNPNETQTNYFGKGKTTTYNRGRFHTLVGTQSRFITYVVDWTAERIIWQADATQLRVLTRRDAEPDQYPQTPMRVKFGAWAGGDPAFNPPGTVAWARGPTDYGKGPFSMLVQSVSVTDYSTGKEYRYKDQSGSDSSIEAVGGAVNANANRNTLAISPNAAASRAGGPDSVPVGGLARDGSQATRSQAGWPWVPGAVPTGGPIPSGWHMTPEGKIMRDAASAAHRLASALPMLLLLLPLVPPRPPCPPPPLMNLGLLPIRSYTVHHQLPESREFTQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKF6</accession>
    <name>A0A367LKF6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">L249_6722</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKF6"/>
    <dbReference type="STRING" id="1330021.A0A367LKF6"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000006">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000011">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="17">
        <location>
            <begin position="508"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="18">
        <location>
            <begin position="707"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="413"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RCI14857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="911" mass="99567" checksum="ABF9905EC4915AF4" modified="2018-11-07" version="1">MTVSQRAKLEGRMSTGAGLGSLGVASWSCGHNRPPSLLANAVATHRIASSLPGRYMYLPDHLRDCTWGRRCMQVTGRGEDWRELRDWKKAGDLVVGPSLTMPLPPPEPGKARDAVLPNLTAALASPVPTRNIVPSRTGHGSSPALPPMTTHWTKPQSCTWTYVANGQASKGAVAWLDLEPVAGASTLSCYPDGMFSDGRTGIFSPATCPDGWYTVTVRVGHRAELLHHTTTAVCCSSYFSYDGFNCKRVVPTVLAVPISYDDAAGTHKVMSNSTTTLYGATMAVNAIRALFMEQDKHLLGLTDDEEIGHEEGDVSSSLSTGARIGIALGVTVVALLSLGAVSFCLFRWRHWRRRKAKGLVLHELASVRECRSPTRESFEPDDAGYDGHDRCILPPPPAYEASTTTGAGRQQAAESADDEIRALEAHKAAIQRRIEELERDNANALPVASPKPVLPASIMKGEIFHIHLGQAGTQLGNSAWELYLLEHGLGLDGRPDPNATDVGDPGSFETFFTETSGGKYVPRALFMDLDPSPIDEIRTGPYRHLFHPELLISGKEDAANNYARGHYTVGKDMVGEVVERVRRVVDNCQSLQGFLIFHSFGGGTGSGFGALLLERLSAEYGKKTKLEFAVYPAPRVHTSVVEPYNAVLSTHSTIENSDCTFLVDNEAVYDICRRSLDIPRPSYDHLNRLIAQVVSSITSSLRFDGALNVDLNEFQTNLVPYPRIHYPLISYAPVVSAAKSAHESFKVHDLTFQCFEPNNQMVVCDPRNGKYMAVALLYRGDVVPRDCTAAIAALKAKASFNLVEWCPTGFKLGINYQRPMAVPAPAEDGGLASVDRSVSMLSNTTAIAEAWSRLDHKFDLMHSKRAFVHWYVGEGMEEGEFSEAREDLAALERDYEEVAADSLEPEEEVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKL8</accession>
    <name>A0A367LKL8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKL8"/>
    <dbReference type="OrthoDB" id="4927870at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="287"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="434" mass="48113" checksum="BAA95AF7BCB319C0" modified="2018-11-07" version="1">MSTQQQQQQQQQQHTRSHLHAKRSTMPDLVPLSLGSPIRRRARLRLIDDEDEDDDDDDNDDDNEEQEQEQEEDNCPPPRSADHHRYSYSSSASRSSIGSTLQSSNFSSRSSISSNGSSSSCFAHQVSSSARLAPPPSPIRLLPSSNAEWRSMLARIRTAFLAAEFDSCYTRCRNILDHARDLDTVSPAYLLYLSFYSAASLDALAGRQSPSRPKLRQLRAQYASALRHANRASISGPPTSPVRRQDERRDQVEDGQQETISWWPKSKKRVSFCELPRNDSPTLGAESWLLSPSSDSSYEQPLSPTSILKPSSPSASTSPSYVTPARDDPSSPPSSPLPPPPPPPPPLSSSSSSSPPRSGISDRYNSLLADIRSQIVSRIASLDAQLAVCAANAVFPSDSTARYEYLRSSGWRRPRFDARRYRALRENALADLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKP9</accession>
    <name>A0A367LKP9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKP9"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="121" mass="14086" checksum="7E154E5FE1735643" modified="2018-11-07" version="1">MKLKLIINWNTMTWLYVTPFRSTTIEVGRYDRYWYSASIARADRCDGCLVPRSIGCYDRYRYSAPIAVTIAVTSRFGRYDRYSPTVTQGVVAGLRPNWYNLFQVALQAYFLSVQDEKICVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKW3</accession>
    <name>A0A367LKW3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6815</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKW3"/>
    <dbReference type="OrthoDB" id="4923590at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017009370" evidence="1">
        <location>
            <begin position="22"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="143" mass="16474" checksum="BF82843580E527C0" modified="2018-11-07" version="1">MFNVTSLIMLSLLSLSPEAEGSSATRKLNYNKRINFKEDATYKKCQSLLPESSCVPELFSAMGAEHMARACRRGGKLSAYEPVFFHLTYFVELKRSVVCAKPVWEPRRCVSFDSYAFTAEQYRPICKTCFPEEEKEEEEEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLA3</accession>
    <name>A0A367LLA3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_6633</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLA3"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI15180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="71" mass="7645" checksum="09B9C398812935ED" modified="2018-11-07" version="1">MLTRRLIPPPTLLCRSYLSSVTYGGLGPATAGPASRNPPRPSGRVPCVCVRVSSAPAKLSFAYLHSMQLYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLD6</accession>
    <name>A0A367LLD6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Histone acetyltransferase type B catalytic subunit</fullName>
            <ecNumber evidence="3 9">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L249_6467</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalytic component of the histone acetylase B (HAT-B) complex. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the HAT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3 9"/>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLD6"/>
    <dbReference type="STRING" id="1330021.A0A367LLD6"/>
    <dbReference type="OrthoDB" id="10253098at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.360.10">
        <property type="entry name" value="Histone acetyl transferase 1 (HAT1), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019467">
        <property type="entry name" value="Hat1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037113">
        <property type="entry name" value="Hat1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017380">
        <property type="entry name" value="Hist_AcTrfase_B-typ_cat-su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013523">
        <property type="entry name" value="Hist_AcTrfase_HAT1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12046">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE TYPE B CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21184">
        <property type="entry name" value="HAT1_C_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10394">
        <property type="entry name" value="Hat1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038084">
        <property type="entry name" value="HAT-B_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histone acetyl transferase HAT1 N-terminal" evidence="15">
        <location>
            <begin position="10"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with histone H4 N-terminus" evidence="11">
        <location>
            <begin position="47"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with histone H4 N-terminus" evidence="11">
        <location>
            <begin position="222"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="449"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="419"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="477"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="261"/>
            <end position="263"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="268"/>
            <end position="274"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with histone H4 N-terminus" evidence="12">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR038084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR038084-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF10394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCI15243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="487" mass="55331" checksum="017A36AB65F414D1" modified="2018-11-07" version="1">MASLPENEDWLSGSNDALSVSLVSPTANGLRQVDKFHPRFTYSIFGDDETIFGYEGLKINLRFRANDMRPHLQIHHDKKLKPLAGQKEPVDVAAVFRDGNHLPQVAFVKESDFEAGSKQLPDDWTPPGTLHATVDATDGQYEIWKGSLADLSVQQLNNRIQILVPLFIEGGTYIGQSPDPNNAEPDLSDADRWTVFLLYKKEKLPDNDEKTSYIFVGFATVYRFFYFQPPAPAAAHSSDWELPKQQMNLADLPCRTRISHFVILPPFQAKGNGSRLYKAIFDHYYHHPQTHELTVENPSEAFDDLRDICDLAFLRTLPEFEELSLDASAKVPESGVLPPLVVGNDKLVSIRKEAKIAPRQFSRVLEMHLMSKLPLSVRPTLDLDADVPSPIKEDKHLEKIWQLFVKQRLYHHNRDALSQIELRERIEKLRETLASVELDYARVTAAHERAMKHSEAQPRLQSNGKRKLDELETETDAASKKPRVESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLM8</accession>
    <name>A0A367LLM8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DUF1740-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_6420</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NRDE2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLM8"/>
    <dbReference type="STRING" id="1330021.A0A367LLM8"/>
    <dbReference type="OrthoDB" id="297219at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902369">
        <property type="term" value="P:negative regulation of RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031048">
        <property type="term" value="P:regulatory ncRNA-mediated heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013633">
        <property type="entry name" value="NRDE-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13471:SF0">
        <property type="entry name" value="NUCLEAR EXOSOME REGULATOR NRDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13471">
        <property type="entry name" value="TETRATRICOPEPTIDE-LIKE HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08424">
        <property type="entry name" value="NRDE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="232"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="91"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI15162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1098" mass="123928" checksum="C71A5603627E036A" modified="2018-11-07" version="1">MAAGDQNTKLSVPKFSSFKHAESKPSLETQKRRRQDEAKEDEKLKAPKFSSFKSEEQHPTDARRRSRRDNDCGEDEDGHRHDKHRHRSHSQKRDILQRDTSRREKEHQGSRRQKPKPEPDPVSSVPGLFVIDTKGDPLITRYGADRYRIPSYYRYGGGRILGTSGRLVIHRDGPLQTFSLLFHGERLSGNRDRDGLRSRDWLKRRPVKLRARRIRPDDEDDDEDFLSLESPRKRRKRNVNSDSSDGEDPTPWRSIEAKVKAGDHQVGDGEEKYSSSSASDGDDPVRWKSSQLHRRVKDYADDIDAWLELVNHQDLLLSGNGASESGLPENAARSLAEVKVHLLESALLHASRPEDRERVLVGLMREGGKVWKRDATSKRWAQISEDEHRSFLLWRVHIDYAMSSIATVQFEDIKTMMVRRLHDVCSRSDLGSSEDLAEAIYVFLRATKFIHDAGYKELAVAAWQGLLEFNLFRPDSVESQAEALAAFRDFWESEVPRLGEPGAQGWRQYVQSGVAGDVPDAAADDEAMKPPRRDTYEAWATAERLCGRKAAMPARTMDAGTDDDPFRVVMCSDIEPLLFLLPRGELVNVTQQLMDAYLLFCGLPPAFRSSEWTDMAWNDQYIVRSRPNPRLQPIREVEAEEQDDSRRKRPMFDGGCCHARISASLLFSGNSWFQYVDVADEEQMVDMSWVETTLKQLIYSANISALALYYLGIRFVRDASSIKKHAKGLLKLYPTDVQLFNSYALAELAAGNVELAEKVLASALGSPTLASASTGFLLFKTWSWLELQRGDKHQATRRLCASVDESLRGSQKDGVVVSASAVLKARQAFAANCRRCLYEGDQETASCYMECLALLSYLKDEGGSEPASTAQGNISAAMEAFASISKDVEFLGGKCEKAHELMLQAASRMLYFHSTRGPFRRAFMREQLANWVEKYRQNTIFMSLFAWADTGSWVKDETRRLLADKVLTKAHDGVSSRISAIGHELARGNVHSARTALEQAVSSEACRSSVGLWLWYVRFCKQKLGLEAGRRVLYRALGCCPWSKDVMMEAFGMGLEEGELRGVYEGMVDKGLRVHVELDGLLSGKGGEVRRGEERRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLT6</accession>
    <name>A0A367LLT6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mediator of RNA polymerase II transcription subunit 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_6506</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLT6"/>
    <dbReference type="STRING" id="1330021.A0A367LLT6"/>
    <dbReference type="OrthoDB" id="203279at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009332">
        <property type="entry name" value="Med22"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06179">
        <property type="entry name" value="Med22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI15360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="22174" checksum="D29DF632C15F1835" modified="2018-11-07" version="1">MSSVYRVADLISNPSYLIDNKITILLTSLTHQTHTHQLASTSSPQLPPFHRYPTKQPNTTMDRSQAPSANLMDIHNRLIADILTRYRTLMMLATVQAEDDRNNATPEAVAVTGISMKMEFDGLYSSIKELLALSRRIKELWVFGPLGEGDPRRREKEAQIGLDVDRVSASLDGLDVARLEALAAENDGTCQARSLQAPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LM44</accession>
    <name>A0A367LM44_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Trafficking protein particle complex II-specific subunit 65 IgD3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_3575</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LM44"/>
    <dbReference type="STRING" id="1330021.A0A367LM44"/>
    <dbReference type="OrthoDB" id="5345392at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055420">
        <property type="entry name" value="IgD3_Trs65"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024662">
        <property type="entry name" value="Trs65"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28159">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX II-SPECIFIC SUBUNIT 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28159:SF1">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX II-SPECIFIC SUBUNIT 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12735">
        <property type="entry name" value="IgD3_Trs65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trafficking protein particle complex II-specific subunit 65 IgD3" evidence="2">
        <location>
            <begin position="437"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI15457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="615" mass="66602" checksum="F54DD4D04D7E713A" modified="2018-11-07" version="1">MNDDDGITAADVSSSFDQDSYLTYMVPFDTNLDLSSLGGSKRSLDSVKQRESFFFDETVHVLLLLKTPWRPDDELRAQLRRLTISLEARIINSNVPGRDSVPAEETIYSGTVQDVSNTLVTIVEHYQDGSDNSKAGRYVYVAWKQPVFLARPRVRPLSPSVVFSASASVGPRPKSEQDAQDAVGYLPSGLPGSINLLESLSTDTALGDVKPRLSASRVSRVAPMMKRQRDSVTQIRAQPQLRLPILPVLHTRIRFSRPNSAPPSPAIVALLEIDFTSHCDSEILLDNISLLTADGTVENLNDETAMKLPLPCVAHDNVTFLYLIKPHQPEGVGLKALSGDLHITIKASVQVEPGVCLPELIMTWHAALDFTMPVNPSFAASVETGIQRSHRPSQLSIGSSSSNIHNNNTTAPTTATPFATPFVGLASQPDSLPSMGAPVANTTTTSNTTTTVQDLGITMSFAGPSKPIHPGDVFLWTVLVVNRSEVGSTSRPPRKLALVAIPRRRRNENLRPLRPPSTASRRRGEAEVADAVVDENVLHAMQRSASADVPDVVCLSPDTRVGPLSPGACHVVELQFLALREGVLGIEAIRIVDVNSQEHVDIRDLPTIVVEPAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMN0</accession>
    <name>A0A367LMN0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_3488</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMN0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI15705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="100" mass="11180" checksum="CDCC6E2D50E531B9" modified="2018-11-07" version="1">MPWVVIWLYTSTMLAIFYTRWRLFQAAFTSLMHSLFYSLFSSPSSIATAPKAHSRTTEGSPAGITPKAATNRYHSYLPSHPKKDASKSATLHVPTQEECA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LN57</accession>
    <name>A0A367LN57_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_1704</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LN57"/>
    <dbReference type="OrthoDB" id="4918515at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000011">
        <property type="entry name" value="Sterigmatocystin biosynthesis polyketide synthase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000031">
        <property type="entry name" value="Sterigmatocystin biosynthesis polyketide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030918">
        <property type="entry name" value="PT_fungal_PKS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04532">
        <property type="entry name" value="PT_fungal_PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF40">
        <property type="entry name" value="NORSOLORINIC ACID SYNTHASE STCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22621">
        <property type="entry name" value="CurL-like_PKS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="8">
        <location>
            <begin position="358"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="9">
        <location>
            <begin position="1275"/>
            <end position="1581"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="1625"/>
            <end position="1703"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="1749"/>
            <end position="1824"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="1872"/>
            <end position="1947"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="5">
        <location>
            <begin position="1275"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="5">
        <location>
            <begin position="1434"/>
            <end position="1581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1591"/>
            <end position="1629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1703"/>
            <end position="1740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1949"/>
            <end position="1970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1602"/>
            <end position="1624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1710"/>
            <end position="1730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1956"/>
            <end position="1967"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="5">
        <location>
            <position position="1307"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="5">
        <location>
            <position position="1494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI15849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2401" mass="260533" checksum="615C0A81154FD560" modified="2018-11-07" version="1">MGNDMQLYLFGDQTFDIQPHFKALLRQRSHPILEDFLTKAYDAVRAEIYKLPYDDRQDVPRFTSLDDLASWNQSGKRSIPLDMAVTCIYQLGSFISQTDSWDSSSSRVAGICTGALAAAAVSCSRNAVELVPLAVEAVTAAFRVGMLVADVAQRVAPSKTLEESWSVLVPGAASYETVRSFCEQTSLPPTSRPYVTAYAPGGITVSGPPAALAQLIASPSFAGLRYKSAPIHGPYHAPHLFSRRDVDAAVSGLAVRGSEHVPLLPVTVGERSFSALLTAAVSGILLQPVRWGDLLDGLQAAVGAVGPAAFRVVPIGTSADQLIYTALKQTPLRSLVPAVAPRPAVPAPASASGSNPGKPKLAIVAMSGRFPGAKDNEAFWDVLHRGLDVHKSVPALHWDSVTHVDPTGRKKNTSAVPFGCWLEDPAQFDARFFNISPREAPQIDPAQRLALMTAYEAIEQAGIVPDATPSTRRDRVGVFYGVTSNDWMETNSAQNIDTYFIPGGNRAFIPGRINYFFKFSGPSYAVDTACSSSLAGIHLACNSLWRGDIDTAIAGGTNVLTNPDFTAGLDRGHFLSRTGNCKTFDDGADGYCRGEGVGTVIIKRLDDAIADNDPILGLILGAYTNHSAESESITRPHSGAQRAIFSKILNQGAVDPYSVSYVEMHGTGTQAGDAGEMSSVLDTFAPPLNQVERGRNADEALYLGSAKANIGHGEAASGVSSLIKVLMMMQRDTIVPHCGIKTRINRKFPTDLRERNVNIALEAKPWTRSSDPDRPRRAFVNNFSAAGGNSALLIEDAPVRAESAARDPRTLHLVACSAKNGVSLQGNLRSMLAFLRRSPDVALGQLSYTTTARRIHHQHRAMLFGGSAQDLCAQIEAALRDNTGMTRPKAIAKPVFAYTGQGAQYPGMGKQLFENLSFFRTEMCRLDDMIQNLGFPSVLPVIQSDETDPGVFSPAAVQLASVGLQIALNKLWASWNVTPSAVVGHSLGEYAALNAAGVLSDADTLYLVGKRAQLLEKMCTRDTHAMLVVKGSVEDIAAVLRRRDYEIACINSPVETVLAGSNDDVSAIKESLATAGFKCTLLKVPYAFHSSQIDPILPSFKEIVKGVTFSDAKIPILCPLNGDVVSNGNGGFGPEYLASHSRQPVNMFKALLAARSNKIITEQTSTLEIGPHPAISGMVKAVLGPQVATLFSLQRGRPSWQVLGTTLKALYTAGADIRWSECHRDFEGSHSVVALPAYSWDLKDYWMQYVNDWSLRKGDPPLTVSATSIESTTVHRIVEEAGDSQRLNMILESDIKREDLSPLVQGHEVDGIPLCTPSVYTDIALSLGKYLGQRYRPDLQDKVLEVSDMNISKALILRGGSGQQLLQSHVDVDWSLQAASIKFMSFDNKQKLQEHSRCVVRFQDGSLRQRLQNDIASVKAKVKSLQDGIVSGTSSRYNRAMAYRAIRPLARFHDDYRAMDEIYLNSDSYEASSRISFGSINKDGDYHTHPAVIDAMSQACAFTMNCNDKTDLDKDVFMNHGWDSLQIFEPLDLNKAYNTYSRMAEGADKLWRGDIVICDGDKVVAHFGQIAIQGVPRRVLKVILSIEAGGKAKPQPSPAPLPKAQQQQQQQQQQQTTPAPKSQPTMPPSKIPKALAIIAEESGLAVEDLTDATIFSDAGIDSLLGLTISARFKEELDMDLDFNALFYEYPTVGDLKGFLGGGVASHDSSGRSTPMSSSTGPSTPRSTATGATIPSPDTFSKLDSATPTKVDFSRALQIISEESGVATEDLTDDTNFADSGVDSLLSLVIVSRYRDELELDIQHESLFLECPTVADLKKLLMGTTCSSAATSHPPLPPPVAEPLFTPSPSPKVNTSSSFVPPPPPAAAAPESKVDFGRALEIISEESGVATEDLTDNTNFADSGIDSLLSLVIVSRYRDELELDIQHESLFLECPTVADLKTLLLGDSSTSQAAMEEQGEEEEEEDEEKPAPVPEVIDDKYSVKRVHIDTAELDGRKRAVDVLVEKHTAGFNLSASTGRLGLPREDEKVVLVTGASGSLGGHLVYHMAQLPDVKTVVCLNRENKEEPYVRQQKAMRGKGIRFPEALKHKLVVLQTDSAKPMFGLSTSVYEGLVNTVTHLIHNAWPMSAKRPLSGFESQFQVMRNLIDFGCHVSSRRPSSFQFSFQMVSSIGVVGHYGLATASDKTRIMVPEKGVGIDSVLPNGYGDAKWGCERMLDETLHNHPNRFRTMVVRLGQIAGSKTSGYWNPMEHFGFLIKSSQTLNALPDVDGTVFWTPVNDIAATLSDLVLSDRKPHSVYHIENPVGQSWRETNAVLADALKIPNLIPFGDWVERVRAAPQRNNPASTLLDFLDGNYLRMSCGGLVLDVKNTLEHSKTLAAVGPVSEEVIRKYIHIWKEIGFLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPA1</accession>
    <name>A0A367LPA1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PHD and RING finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_2175</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPA1"/>
    <dbReference type="STRING" id="1330021.A0A367LPA1"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15545">
        <property type="entry name" value="PHD_BAZ2A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047157">
        <property type="entry name" value="PHRF1/Atg35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12618">
        <property type="entry name" value="PHD AND RING FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12618:SF20">
        <property type="entry name" value="PHD AND RING FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="7"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="118"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="286"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="367"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="489"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI16275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="654" mass="73411" checksum="78CA1BD0FC05BF9A" modified="2018-11-07" version="1">MSEPEQCIICLDPLPLPSSSSPKISSVVPPDSDDAAHLDIVAALDGCEHIIHDACIRSWAQKTNTCPICRNPFHCVRVYNGVDGTVLSTYNVQDRKQVAEFDVQQWLSQNPDDDEEPSNPCPICNSADREDVLLLCDSCDAAYHTHCIGLDYVPEGDWYCMECSHLFDLTDEPQAPADPAPAEPRLLGLRRPNPREIRGYHVRTRARLRRARRQARNAEWQGAWGQFSGRFFEMSDLDLDNHDDDEELGQYRRFQQQDQQELQRWQQRVNIAQRLGAREEFVDVIPPQISERLQPPPQPVVETRDERRAWGALDRARETDLVNGGGTGSRKRRTRSVTESPSEPIPEPERKLKRPRTRRLPTQGEGSTSASSPAAAAGPSAPMSRNGLGRSENETPLVSSLLRELEPLEPNGPSEEETPAQTFYWRVPPEASSPALSPSTSNHSSPRALSLTPPPLPRTNGREASPTMSLSTHIEPRYPPANYSPNRPTSDHSDSETQMRPLELRHPRPRRPCPVPPRSKDLSPTRPAVTQVEKSPAKSVVEQTGKKSSPKPARMPAKKSPAKSSRALADKSPTKLAMTQEEKKSINDIVKTALRPHWRAQKLTTEQYEVINRAISRKLYDELRDATSLDEESRRSWEKRATQEVARAVAELKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPH9</accession>
    <name>A0A367LPH9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Holocytochrome c-type synthase</fullName>
            <ecNumber evidence="10">4.4.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_2629</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>holo-[cytochrome c] = apo-[cytochrome c] + heme b</text>
            <dbReference type="Rhea" id="RHEA:22648"/>
            <dbReference type="Rhea" id="RHEA-COMP:10725"/>
            <dbReference type="Rhea" id="RHEA-COMP:10726"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="ChEBI" id="CHEBI:83739"/>
            <dbReference type="EC" id="4.4.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the cytochrome c-type heme lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.17" evidence="10"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPH9"/>
    <dbReference type="STRING" id="1330021.A0A367LPH9"/>
    <dbReference type="OrthoDB" id="1158011at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004408">
        <property type="term" value="F:holocytochrome-c synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000511">
        <property type="entry name" value="Holocyt_c/c1_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743">
        <property type="entry name" value="CYTOCHROME C1 HEME LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12743:SF3">
        <property type="entry name" value="HOLOCYTOCHROME-C SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01265">
        <property type="entry name" value="Cyto_heme_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00821">
        <property type="entry name" value="CYTO_HEME_LYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00822">
        <property type="entry name" value="CYTO_HEME_LYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0349">Heme</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="9 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI16343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="297" mass="34034" checksum="FE24F4B2F7696D2C" modified="2018-11-07" version="1">MGWFWADAAPPRPAQRAPPTACPVKHDVKPPRMPPSGCPVPHMSKADDRPSSVLSKLNPLNYMFSDLSQKPAPNQKISLPTKREESTIPKGSGDGRWEYPSPQQMYNALLRKGYTDTDATAVESMVSVHNFLNEGAWNEVLGWEQRFSRGLYKGWQVCKRGEAHTAEELERHWDGTEGRPSLVRFQGRPKDLTPKATMIQVLGWIYPSKFGTELPFDRHDWYVSRQVDGKEQKQIRYVIDYYSGEPEPNGDPVFYLDVRPAATPLGATERFIRWGTDVWWRAIGGDTREQNPFRFWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPP1</accession>
    <name>A0A367LPP1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_2741</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPP1"/>
    <dbReference type="STRING" id="1330021.A0A367LPP1"/>
    <dbReference type="OrthoDB" id="4202871at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI16361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="680" mass="74970" checksum="BA6B9119F61BE747" modified="2018-11-07" version="1">MPWSLVTVNNNVSLISLNVAASSYLASLVVVAVFLGLYLPRLSSRIARLEPITTATAFLPRRQILATDKPLPNNSTSTGIIIIPIVIINFNINTENKSSSSSSSNSSSSPPPPAPVMVPPPDRLEASLQDFEAPVSPTSMRHSSALPSEPPMEDGEESDTASAGGYSPPAWRNLGNGDRSRGFWNPPMARYRPFSPVSDDCPSDDDDILEKAIRTRLPQGSMSPEKGPSPTPDRVRRTVTATPAAPRLPTKSQTPKLALAEMAQPENYIRFAVRAEVLQRTRPIEAALAFVQKQYRYFTSSWVSVLTSLVIALLCVSTAKTLVKPAAPRPVGDLVKVAGLARSFEPLIYFSEPAVAHVRELQSTSIAVWDLGESVRISGMADAGTIVQSLEAISETMKKLVLDLTRFHTHVDGDIDAILNVMDWAKMHLNRINTRPPPSHLSHAYDNIHNLLSDAQVLEDETGEPTRLGKLTTAVFGMSNPQREQRMVQRLFTVFISTLEEAIGDELEHSVSLFALFDEIDDHFLRLARYVAHESSTQDDFHAELLSGLWARMLGPRAPELRKFERNKALLHNVRQKTVRNKGNLISHHGKLLTLKSSLESLRGKLASHLVRGLNSSTLTLDDQIRGIAGVRDYLSDIRRQQKTKVMEALYSIDRSKKYDLGPDIGRIMEDDVGAGLLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPV2</accession>
    <name>A0A367LPV2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAC3/GANP/THP3 conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_2886</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPV2"/>
    <dbReference type="STRING" id="1330021.A0A367LPV2"/>
    <dbReference type="OrthoDB" id="199574at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.990:FF:000006">
        <property type="entry name" value="Putative SAC3/GANP domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF4">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC3/GANP/THP3 conserved" evidence="2">
        <location>
            <begin position="245"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI16473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="504" mass="56978" checksum="24C2145513227B8D" modified="2018-11-07" version="1">MVPAWPATPQHAPRVSPAATPGSYAFPANPAFVPVQVRRHGLAHPVKTTPPFTGYAAPSPAKTPPEPPKSKTDWPESVRLYVQRSFLPQNDDPSVSRTELENKLKETIGTAKEEGKLHSIDWDSMPLPQTMVKAERDALLQNNHPSMATLSLQSHNPKKRKSSDMEDSRRSPPWRSANRTSLQSRISHPASDRRFAADSVKSSKFQKEANKRKRRFENEYKAVHRSPSPTPPSSGPIVGTSDALEKKYLRLTAPPIPSNVRPEKILRQTLDLLKKKWRKEGNYSYICDQFKSMRQDLTVQRIKNDFTVAVYEIHARIALEKGDIGEYNQCQTQLRSLYGMGLKGNPIEFKAYRILYFIHTANRMGLNDTLADLTTAEKQERPIKHAIAVRSALALGNHHEFFRLYMDTPNMGAYLMDMFVVRERLAALCNICKGYKPEVNVDFLTTELAFESDEDAVQFIIDHKGEHLLDNRKDHIAFLSGKAGPLFESVKSAAFRKVDIKGQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPY3</accession>
    <name>A0A367LPY3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_2277</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPY3"/>
    <dbReference type="STRING" id="1330021.A0A367LPY3"/>
    <dbReference type="OrthoDB" id="38045at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000220">
        <property type="entry name" value="UDP-galactopyranose mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734:SF4">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734">
        <property type="entry name" value="PHYTOENE DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016712828" description="Amine oxidase domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI16505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="573" mass="63826" checksum="21EA64C369437FA9" modified="2018-11-07" version="1" fragment="single">RQLPFVVRHLSLLLVLRGHFVAGEPLCHHRLPPPSNRVQPSLPISVTMGGADINVDVLIIGMGPTGLGAAKRLHQINGPSWLLVDSADKAGGLASTDVTPEGFLYDVGGHVIFSHYKYFDDCIDEALPKEDDWFTHERISYVRYKGLWVPYPFQNNISMLPKEDQVKCMDGLIDAAMECRVANTKPKDFDEWIVRMTGTGIADIFMRPYNYKVWAVPTTKMQCQWLGERVAAPDIKTVTKNVILNKVAGNWGPNATFRFPARDGTGGIWIAVAETLPDSKKRFGKQGEVTKVDAAKKTVTLADGKTIAYGKLINTMAVDHLVEKMGNQELIGLSKGLFYSTTHVIGVGIRGERPDRIGDKCWLYFPEDNCPFYRATIFSNYSPYNQPQADVKLPTLYLADGTKGSSDAKKGPYWSIMLEVSQSSMKPVDEKNLLKDCIQGLINTEMLKPEDEIVSTYHRRFDHGYPTPSLEREGVLKQLLPKLQDMEIYSRGRFGSWRYEVGNQDHSFMLGVEAADHIVNGAVELTLNYPDFVNTRQNNERRLAPALGFSNGTGVNGSADGHARQRAASKATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPZ6</accession>
    <name>A0A367LPZ6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histidine kinase</fullName>
            <ecNumber evidence="3">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">L249_2274</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LPZ6"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000003">
        <property type="entry name" value="Histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000044">
        <property type="entry name" value="Putative sensor histidine kinase/response regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000285">
        <property type="entry name" value="Putative sensor histidine kinase/response regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000010">
        <property type="entry name" value="Sensor histidine kinase RcsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000579">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF46">
        <property type="entry name" value="HISTIDINE KINASE_RESPONSE REGULATOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13185">
        <property type="entry name" value="GAF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 13" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="87"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="16">
        <location>
            <begin position="2000"/>
            <end position="2225"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="17">
        <location>
            <begin position="2274"/>
            <end position="2398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="63"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="480"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="551"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="704"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="2234"/>
            <end position="2257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="2410"/>
            <end position="2429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="2452"/>
            <end position="2545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="551"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="720"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="2247"/>
            <end position="2257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="2464"/>
            <end position="2494"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="13">
        <location>
            <position position="2329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RCI16506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="2545" mass="279671" checksum="50B33815DB0074F0" modified="2018-11-07" version="1">MNDVVRAPDDALDPPPPPPPPPRLFDRLRQIAGYTWDEAQPPVHSTYDFWHVFGTRFVTSAVTTPSLQQPDPVTRLQSGRPSPSDQFPFDSQQSSNDSGRPLVTQLPSTPSNSTEPSCVEEPVVARVSLHAVREERAFQLAKSVIATADPNGDHIVRPLDLIRLNPAAGDRSPLIVAIYAHPGHNFLHDVLEMGPAFYTAKRVNSDTSLVSHRASPSTSKPPINLEYFLDFAIGAAHCLEILHHGLGMVHGEIRGDAFHFDAEDNKVRIESFGSGIRSFEHGLTSTGWSTLSREVGAKNKLLYISPEQTGRMPAEPDTRTDIYSLGALLWTLLTRQPVYSGDSPLDIVQGVLGRRIPNVATVRMDIPEVVGRIIQKCTAKNVADRYHSASGLRHDLLRVQQLLAHGDSSALKDMMIGSRDVSSFFMLPTAIIGRQGEMNDLIRVIDRVAKLHAVHLKGPASRFVEGSCLTGEAVLADDMSSEGASSADGTLRRSGSFTQPTCSDAKLSKTGLHSSLLLSDSQTLSAETLSVHSAGGFFTRPTRAWDRHLSMSTETASATDGATESARDSTSGSSLSRHLGNAKFRRRGQCEIVIIEGAGGLGKSSLVQSVLPEARRRGYCATAKFDTARRTAFGPLLRLLSSLFKQVWGERNTETAFHQGLKQYVRPVWPMLHRALGLPEFLLGSPETGLPRCLPCLMPQQQQQQQQQTGGCHGNGQSGGLAPSSPSPVSSPATLPPNPSTSQQSPQDYLCAGTTTKTTRLMNTCLDILRVFTAHKFITFCLDDVHFADDESLELISQIIGARMRMVIIMTYRPEELPREKIEKIIYPAEAADGAGVNRNSLTALGVKTADAEAEASRTSRPVVTRIKLSPLSEDDILGYVSSLLSRPKEETLPLALVIQSKSAGNPFYMREMLSACHRKKCIWYDYRDSQWHYDLDKLFAQFQGERDHNVIDTGFITQRLNELPSTARAVLAWAALLGNSFSFELIARLMRGEFEYDDGCCHDPLKRSYTEGEAIAGLQAAVQAFIIVPSETDDRFRFAHDRYIHASAALKECNARRMHYIISLVLLKYYADEARQRDSTASHICEAVSIIKSRVPQRREFRRLLIDCAQAAVENGARPTAAKYYSTAIQLLQDRPWARDADDASYEETMQLHLRSAECYLFMGQLSGADELLSTIFANAKTPVDKAPAYVLQSRIFGQNGNALAAFVSLKECLAALGVPLNDEPTYERCDEWFERLATQIRRMDRSELVQPRSSGEAIIASIGAVLSETASAAWWSDCLHFYHLTLVMLEVHLARGAFPQSGMAFLNMGVVALSRFGMTRFAVEMGSVCRELLCQTGDAFTMARGQMLHTCCIGHVQHAMSVTVTEMEDAIEMASVGGDRLSTILSYGLCAQAKFFASENCVDLETFCQYGCEDIPNWSYDTRGGALVVAVRQLCRALQGKTRVEDAAGVLSDEQHDGDAYKGWLTSQTRESNRSSLFYESIELVALFLYGHHERAVEVGRRCCQLLSMLWSARNSRLMLLFYGLSRTGQLLRQMHDPRRAAGTDFSAQKDEVVAELGRFVDMMLNWSAVSDVNYRSWTQLLKAQMAELREDHGQAIQHYEEALDHAAEHDFVFEEALGNYLLAGFFIRRKARRTARAALRDAVGLYRQMAASGVARVIEEEHSLLLHGPSRNYRTAEVGIQTDFVADAQPVQYPNVDEGDGGDDGRRFPASSLMSELRGDRFGVWRGSMDMSVAGEGGVGSGGGGVGGWQQRLRRRRRGGLPALDMIDLHAILVSSQVISSVLQVDELLKTMCDVVLQTCGGAATRAAIVVQETEAESWCVAASGNPERGAMAHKPGLPLSGTALVAENVVLYCTRFLEPVFIPDLLADERFGNVSEAWLQRNRLGKAIIAIPICHGTKPLLGVLYLEGEPGSFTDRNVTVLQLLVNQIGISYSNALSMKNVEKISAENRSMVSVQKRALAKALEAETKAKNAEAEAKRNVKLAEEAAKAKSIFLANVSHELRTPLNGVIGNSELLRDSQLNREQLEMADSIRVSADLLLTVINDILDFSKMEADKMKLYIIAFNPEEMVREVVRAVSYSNREKTSKKNVEIIQDIKLPSMLIYGDPIRLHQVLGNLIGNSLKFTEDGSITIGARLDSETEERATLTFWVRDTGIGIPPQQLAKLFQPFSQADASTARKYGGSGLGLSICKSLIEMMMKGKIQLESEETVGTTAWFTVSFEKAKADVAAGDALSKSSPPIDRYSATTSASERAASPNPFLDLTQLRKEEVRICVAEDNPINQKIAIQYVQRLGYPSVSAYENGLKAVEGLRQKAREGKPYHIVLMDVQMPVLDGYEATKLLRRDAVEAVRKVLVIAMTASAIQGDREKCLAAGMNDYLAKPVRSDVLRRKLDAYVCNARRYLAMPSPPSPLNLPRNVCGPESNGSGMEGLTMPMAVTKPVPMSLMTVRDGQASSNGTHAVSLPSSSSSSSSSSSPPDASGQRRQQQQQQPRRLPKSRAGGETGVTEKATWKDGAARGVLTKRGPQHKTNMADLAPRQRSPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRE5</accession>
    <name>A0A367LRE5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_2306</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRE5"/>
    <dbReference type="OrthoDB" id="432881at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140575">
        <property type="term" value="F:transmembrane monodehydroascorbate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08761">
        <property type="entry name" value="Cyt_b561_CYB561D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045150">
        <property type="entry name" value="CYB561D1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422:SF45">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15422">
        <property type="entry name" value="OS05G0565100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03188">
        <property type="entry name" value="Cytochrom_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50939">
        <property type="entry name" value="CYTOCHROME_B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="144"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="218"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="13">
        <location>
            <begin position="41"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI16989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="254" mass="27580" checksum="31AD691812474397" modified="2018-11-07" version="1">MASSTGIPARSEAGRPEPSDAEPLLGRPGDVLQRRNTSFARNFVMGTASLAQLGAILGLVLVWASVFNKPLILFSAHPLLQSLAVFVLIQSVLSLQPTHTSEQKRLGQLVHASLNLLALCLLIAGVTIIEYNKVSSGGPHFHSFHGYLGVIVSIVLLIQYVVGFTMWAVPALYGGEVRARAVWKYHRYSGYLVLLLLLVTVCSAADTDYNRNVLHMKLWAAILASALVVLGVFPRIQKYKLGLGLPAQSRESAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRK4</accession>
    <name>A0A367LRK4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_1773</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRK4"/>
    <dbReference type="STRING" id="1330021.A0A367LRK4"/>
    <dbReference type="OrthoDB" id="5363962at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF25">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14390)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="10">
        <location>
            <begin position="31"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="9">
        <location>
            <begin position="186"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI16862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="381" mass="40596" checksum="5D70F51A81D7C386" modified="2018-11-07" version="1">MSSPQQLIRASVLHGAGDLRLEDRPLPPPAADEVQLSIQSTGLCGSDLHYFKHFRNGDIVVREPLTLGHESSGTVVAVGEGVKDVKTGDRVALEVGVPCESCQDCSQGRYNICREMRFRSSAKAFPHAQGTLQARVNHPAKWCHRLPDGVDFHLGALAEPLSVAVHASCRAALPAGVSVLVFGAGAVGLLAAAVSKAGGADAVVVADIQKERVDFAVDRGFADAGFVVPMARPQTMDEKLAYARQVADQIAAVRVSGRPLGQVSAVYECTGVESCFQSAIYATKPGGKIMIIGMGNPIMTLPISAAALREVDLVGVFRYANSYPKAIELLSNPPAAMPDLRTLVTHRFKGMDRINDAFLMAGRVKDDEDQLVLKVVVDMES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRL1</accession>
    <name>A0A367LRL1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Ceramide very long chain fatty acid hydroxylase</fullName>
            <ecNumber evidence="18">1.-.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">L249_2325</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Ceramide hydroxylase involved in the hydroxylation of sphingolipid-associated very long chain fatty acids. Postulated to hydroxylate the very long chain fatty acid of dihydroceramides and phytoceramides at C-2.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18 19">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="18 19">Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the sterol desaturase family. SCS7 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.-.-.-" evidence="18"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRL1"/>
    <dbReference type="STRING" id="1330021.A0A367LRL1"/>
    <dbReference type="OrthoDB" id="2204368at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080132">
        <property type="term" value="F:fatty acid 2-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014430">
        <property type="entry name" value="Scs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863:SF1">
        <property type="entry name" value="FATTY ACID 2-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12863">
        <property type="entry name" value="FATTY ACID HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005149">
        <property type="entry name" value="IPC-B_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 18" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="17 18" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="10 18" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 20" id="KW-0349">Heme</keyword>
    <keyword evidence="14 18 20" id="KW-0408">Iron</keyword>
    <keyword evidence="5 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 18 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 18 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11 19" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="23">
        <location>
            <begin position="6"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="20">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="20">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="260"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="339"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR005149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR005149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR005149-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="RCI17051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="370" mass="42705" checksum="CE993E41028BC18D" modified="2018-11-07" version="1">MPSRTIPTLTREEVESHNSAASCYVTMGSKVFDVTYFLHDHPGGADLILEYAGKDVRDILQDSASHPHSEAAYDILDDSLIAFVTPPKVVAANGAVSKPAPDTGPQVHPRTGMSCEEDLSKETDYSQDYKKHKFLDLGRPLFPQIWYSGFSKEFYLDQVHRPRHYRGGQSAPLFGNFLEPLTKTPWWLVPMIWMPCVAYGTHLASQGRYGVTATASFWILGVFLWTLIEYGMHRFLFHLDEFLPDNRYGITAHFLLHGVHHYLPMDKYRLVMPPTLFIVLATPFWHVTHTVFFFDWHLATAVFCGGIFGYICYDLTHYFLHHENLPLWYKQLKKYHLQHHFLDYELGFGVTSKFWDTMFGTELQPVMKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LSU9</accession>
    <name>A0A367LSU9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_3309</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LSU9"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI17420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="37" mass="4440" checksum="7E51CF3D415F712C" modified="2018-11-07" version="1" fragment="single">RSIRSTRTSLPLNYRSSKYVRVLQVGTLKYLEKYLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LTM4</accession>
    <name>A0A367LTM4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_2659</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LTM4"/>
    <dbReference type="OrthoDB" id="5244290at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI17472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="72" mass="7995" checksum="13D8E8B8B6D58415" modified="2018-11-07" version="1">METNKTRHDVLDKIPKVGDAPSVVVRLILIIFTRHLNATEDDVLEARELAASMSLESVHSVRVLVVTDVAFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L008</accession>
    <name>A0A367L008_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">White collar 1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">L249_1669</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000026">
        <property type="protein sequence ID" value="RCI07552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L008"/>
    <dbReference type="STRING" id="1330021.A0A367L008"/>
    <dbReference type="OrthoDB" id="447251at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000064">
        <property type="entry name" value="Vivid PAS protein VVD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000063">
        <property type="entry name" value="White collar 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013654">
        <property type="entry name" value="PAS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429:SF7">
        <property type="entry name" value="GATA-FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429">
        <property type="entry name" value="PROTEIN TWIN LOV 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08446">
        <property type="entry name" value="PAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0157">Chromophore</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PAS" evidence="17">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="17">
        <location>
            <begin position="577"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="17">
        <location>
            <begin position="714"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="18">
        <location>
            <begin position="921"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="250"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="813"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="956"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="12"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="250"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="283"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="813"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="957"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1030"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1061"/>
            <end position="1070"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RCI07552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1070" mass="116419" checksum="CF06D295C80D5EF7" modified="2018-11-07" version="1">MDGFYAHPQLPPQQLRRQLSRQRQQQQQTQQTQSQQTQSQQTQAQQPQQQRPAPPQQSMSMPVQLSLQSQSPMSQAITDQSVMSGSSIDDMLRNNQDDLQRRRSMSHTYRDPAAQSQSPRRMSSIGGAGDIMQFSSDNNNLRNYHFTPSMAAGIANINTGIHMTDQLGNYMTEADDYSAISPDLMGSMIPASFANMDMGPIGNDSSAMGLFSTPGSSNAGCGPGTGSMGNEFSPGQMATVGADFSLGVNTNGSSISATPNTFKESVETAEERDDDPMKLPASQFPSMGSTPNPVTNSMNLDSNVGGYNQSLQPPLSRHVSSPASFISPQHGSSSNSAAQASAASDATTPTTAPTPRETKDKAIYSKSGFDMLKALWLVATRKDPIIHLGAVDLSCAFVVCDVTMNDCPIIYVSDNFQNLTGYSRHEIVGQNCRFLQAPDAKVEAGSKREFVDDGAVYNLKKMIHEGREVQQSLINYRKGGKPFLNLLTMIPIPWDTDDIRYFIGFQIDLVECPDAISGQELGGVTVNYKHTDIGQYIWTPPSTTQWEPENGQTLGVDDVSTLLQQFNPKGLVSDWHKQSWDKMLLENTDDVVHVLSLKGLFLYLSPSCKRVLEYDAADLAGNSLSSVCHPSDIVPVTRELKDATAGNQVNIVFRIRRKQSGYTWFESHGSLFVEQGKGRKCIILVGRKRPVFALSRQNLEANGGIGDSELWTKLSTSGMFLFVSSNVRSLLDLQPESLIGTSIQDLMRKESRHEFGRSIEKARRGKIVSCKHEVQNRRGQGLQAQTILYPGDASAGQKPSFLLAQTKLLKASSRSMAHSGTPGSNKSVTGTPRSNSQTQGSHHEGTISQPSGGSLLPGTQDLALASDDNIFDELRTTKCSSWQFELRQMEKVNRILAEELGGLLSNKKKRKRRKGVGNMVRDCANCHTRNTPEWRRGPSGQRDLCNSCGLRWAKQTGRVSARNSSRGGNGDSQSKRSASPIQSSPLHKEYLAETPNPHAPDATAAIGRPAEGHDSIDPAQLGGLLAGVSTVPNAASSAKPMSTMPPPCHPSLAPGSSMTSIREERETSQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L060</accession>
    <name>A0A367L060_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_5798</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000023">
        <property type="protein sequence ID" value="RCI07804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L060"/>
    <dbReference type="STRING" id="1330021.A0A367L060"/>
    <dbReference type="OrthoDB" id="10265211at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20704">
        <property type="entry name" value="Orc3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020795">
        <property type="entry name" value="ORC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045667">
        <property type="entry name" value="ORC3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040855">
        <property type="entry name" value="ORC_WH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07034">
        <property type="entry name" value="ORC3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18137">
        <property type="entry name" value="WHD_ORC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 3 N-terminal" evidence="7">
        <location>
            <begin position="33"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 3 winged helix C-terminal" evidence="8">
        <location>
            <begin position="579"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="639"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="639"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="663"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="691"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF18137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI07804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="743" mass="83151" checksum="6D93BECCAFE71886" modified="2018-11-07" version="1">MGPPQDHQLAYLLSADEKETRPAKRRKVSRQTKRNAEEPLFVPLLNGAERPECVKLRQRLFEEAWGKVEGRIQEILRGANSSTLEQVSDFIPAAFIITGHNMASQDLLFEQLSETLQRSSASKFVCLRSSEATTLKAALKKTIRDAGDGDDVQAKPGREGRRRYLDYDLEALEASLEHEACKDVFVAFQDSEGFDSGLLSDLMTLFHSWRPRIPFTLLFGIATSVELLQARLLKSACRLVYGAQFDCVQTETILDTVFRGAVAAADVSLRLGGPLLRSMLERQHTQMAGIQAFISSLKYGYMCHFYANALSVVDSWDVEMLQAEHVEALRNLASFRKDVERAVGEGSDESMAHARSLLEDDAYLVTQVGEMGQRRQRWVERVLRRVLCLEAAAAAASTAGGQRDKTFPEAYADAVSGDGAGLAEQMDRIRRSGADELVTVIRRVLAVLERGDDRLALGPWADDEGVEARRSLQRSLAEVERLQAAARAGGFSLRNRHGGQSKVLRTTVVGQRVQLSQDSAALREEDGRLTEVVDEVVGLLTTRVLMAGSGSGPETVIFSECWLYDSRRPMRDVLVPRPRAVFERSLGRPRDYLGGGGGGGEAPVPVPATCLLYRLYLETGSLINVADLWTAFAELGMKEKEKEREREREREREREKEKEKEKEKKKKKKKKKRMRAKTGGDEEGEQEEKTKTKKNKKKNNKGAADKERETLALFYRGLAELQAMGFIKATKRKTDHVAKVRWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0T6</accession>
    <name>A0A367L0T6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7847</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000022">
        <property type="protein sequence ID" value="RCI08049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0T6"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI08049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="240" mass="27047" checksum="186E2E26A1325D0A" modified="2018-11-07" version="1">MSSDMLRCFFLNISSTAVRKRNETKRSETKLQFHTIQLSTSTMTVALEDGNTNQLVLPCMSSSHGRPPLVRETMTKLHNQTLRNAALGLLNDFDEAAMVKQLKATKDPTRREGYDPDSLVRWRVKHLPPLFLPARGGIFDLRRSTELGSLTWQRTPYRLPGSEKSKHHGCWYLHDILPHRCLRSQSTFETGSSLLISHPSNTLVTIVKMPVPALFPSTPTHGKTAVKRFLSDLVSTDLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1V0</accession>
    <name>A0A367L1V0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8861</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1V0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="125" mass="13985" checksum="40CA69D0466D873B" modified="2018-11-07" version="1" fragment="single">VGGRGRARGRGRARGGRGSDTCGIPAKGRYYSLCQGQEGFFPPRRDTTIQAGAYSASARDKSDTTQAAGVYLALGQQTIRSGSRRCWEEEEEEEEDEEEEEDKEDEEEEEDKEEDKETLLFRPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L223</accession>
    <name>A0A367L223_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">V-ATPase proteolipid subunit C-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_8981</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Proton-conducting pore forming subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10 11">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L223"/>
    <dbReference type="STRING" id="1330021.A0A367L223"/>
    <dbReference type="OrthoDB" id="10264021at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18177">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6F_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18178">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6F_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000002">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="138"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="175"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="67"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="12">
        <location>
            <begin position="141"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI08464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="211" mass="21345" checksum="9DF45D5BDFE12051" modified="2018-11-07" version="1">MSLKYGIGGIGSFLAVAGASSCPPPAPSRADPLTIADTLFTGSGEAFNVGAFLESVSPYAWADLGIALCIGLGIFITGSSILGAGVKAPRIRTKNLISIIFCEVVAIYGVIMSIVFSSKVDIVDGAEAFSANSYYTGFALFWSGLTVGLCNLVCGVAVGINGSGAALADAADASLFVKILVIEIFSSVLGLFGLIIGLLVSGKANAFGKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L251</accession>
    <name>A0A367L251_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8846</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L251"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="93" mass="10749" checksum="3AD7DC8AE3B0BD4D" modified="2018-11-07" version="1" fragment="single">AAPPPPRSLRRSGRQSVSSQVYYRQSWDDNFIMYFINVIDKSLNRTTLDDTYRMNRKRRKKESHREKTVSGQTPPLLAEGGTACASFSFHRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2H3</accession>
    <name>A0A367L2H3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_4861</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPO2/CSE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2H3"/>
    <dbReference type="STRING" id="1330021.A0A367L2H3"/>
    <dbReference type="OrthoDB" id="3268246at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005043">
        <property type="entry name" value="XPO2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013713">
        <property type="entry name" value="XPO2_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF8">
        <property type="entry name" value="EXPORTIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03378">
        <property type="entry name" value="CAS_CSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08506">
        <property type="entry name" value="Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="8">
        <location>
            <begin position="24"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI08608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="978" mass="109240" checksum="F4B4BB3BE8B2171B" modified="2018-11-07" version="1">MAADIGHIAQLLDATLNPSQHRKAEAALKQEATKPQYSLSLLNIVSSESLPSTTRLSAALAFKNFIRSNYVDEDGLYKLPGQEVQTIKDRLIGLMISCPSNVQSQLGETIAIIADSDFWERWSTLTQVRLRNQFCLSFANRLSSLAQDLVSRFSASDPKINVGVLEVAHSIFARWRPLLRSDELYTEINHVIATFGEPFVQLLVNTDGKIAENKDNKEALQLWFETLRLQVEIIYDMSSHDLPPIFEDHLGNISMLLHKYLTYSNPLLETDDDSEAGTLLTVKADICGLLELLTLRYDDDFNKYCNPFITSVWELLSSTGPETKYDNFVSKALHFLTAVAKAPQHLGKFDDSQVLNEIVEKVILPNVALRESDIEMFEDEPIEFIRRDLEGSDNDSRRRSATDLVGALLSKHENLVTGIVIKYMNHYLVEGNNGWKSKDTAVYLFMSVAAKGAVTAAQGVKTVNPLLDVVSFFEQHIAADLMGDQVAPISKVDAIKYLYTFRSQLSKEQWKLALGPLIQNLNSPNYVVYTYAATAVERVLYLADDAGNQVFTRADIEPFAKDLLSHLFKLIEQDTSPPKLQENEFLMRCVMRILIVLKDGATAMLDNVLTHLVLITNVMKQNPSNPRFYYYHFEAMGALVRYCSVSSEGLFNEKLWEPFQRILMEDVTEFLPYIFQILAQLLESSPSEGLSDNFKALLGPLLAAPLWETRGNVPACTRLLSAVIPKASKVIVEENQLEPVLGIFQKLVGGKKSELLAFDILDAVVQSFDSTTLDKYFCTIIQLLYRKLQATPTDSFKLRFARFYHLVSAKLEDGFGADYFIKHSDQVDERAFTQVYPALVLAETEKLAKPVDRKLAVVSLTKTLCESQAFAQKFAKGWANSCRILLSLLTNPPVVAKGSGGEIITEASVDDVGFGLTFTALNTCKPASRDPFADITDVTSWVKQYMAAANARHGGAVATFVSSRLTPEMQAAMAQYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2S8</accession>
    <name>A0A367L2S8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_4685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2S8"/>
    <dbReference type="OrthoDB" id="5419460at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045121">
        <property type="term" value="C:membrane raft"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030866">
        <property type="term" value="P:cortical actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032185">
        <property type="term" value="P:septin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36414">
        <property type="entry name" value="PROTEIN SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36414:SF1">
        <property type="entry name" value="PROTEIN SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="262"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI08724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="416" mass="47422" checksum="41A6C59472346247" modified="2018-11-07" version="1">MLRWGCLPPARHVGSHPDIPTFPSYSNLLSTGMEWKRSSPDALSRLYHRRWTMSSYPSFETELCSLFGIVLTCSHVPTSGNKIGATSSPCGQHGTTKILPRTTKMHVKQKRIKLTRILTRESDTPLATIGIFWLLLAGILLWFIILSGVTRGTPLKHTYFLRADTSNITGARDITQWAYFRICGDRNRDCHAHGAQSFGRAWAPHAENVPPALMGKWDDHTSSFHYFMMWRFGWVFLIFTFFFLHVALFSALIACCGRRGSIFTLLMCVITWFWYTLAVSIITAVFCQARSKFHRAGRKARIGSWAFGFLWSSYACVILACLYFLWSSRIFKRRYEDDADNHAITAGRRGAAAVFWRRRSSSRPRQSRDDDDGGGHDHRRDHCGQDGSNHDYRTSQSSSDDDLFGTRPGHKETRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2W2</accession>
    <name>A0A367L2W2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_4721</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2W2"/>
    <dbReference type="STRING" id="1330021.A0A367L2W2"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08023">
        <property type="entry name" value="GH16_laminarinase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF53">
        <property type="entry name" value="GH16 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH16" evidence="2">
        <location>
            <begin position="34"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI08748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="294" mass="33026" checksum="9AEB8CEE637D8F07" modified="2018-11-07" version="1">MSWKDQLQRVKDKFDSHRSPSSSSRPPSQQAPEAYWKPRFEPAVAVGDDWEAKIGNGPDGWGNQELEYYTAEPANSFHTDDGKLVIRAVADNSSTEADKKYTSARLVSRQTLARDQGVLTAVIQSPCADGIWPAFWLLPQEPFSWPTDGEIDIAETWNGDCENKSCLHWGFHHEPQKHRVLGTKIPDMHCRPVRYDFAWQQPDGRPGQGRLLWYLDGKPVMKASIPEGTRPMRDMNILLNVAMGGNVCGGKTPADGSYDMIVSTLFLSPELENGGWERFDRDWQSEATPGGNTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2Y3</accession>
    <name>A0A367L2Y3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_4782</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2Y3"/>
    <dbReference type="STRING" id="1330021.A0A367L2Y3"/>
    <dbReference type="OrthoDB" id="201515at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008418">
        <property type="term" value="F:protein-N-terminal asparagine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070773">
        <property type="term" value="F:protein-N-terminal glutamine amidohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07566">
        <property type="entry name" value="ScNTA1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039703">
        <property type="entry name" value="Nta1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11750">
        <property type="entry name" value="PROTEIN N-TERMINAL AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11750:SF26">
        <property type="entry name" value="PROTEIN N-TERMINAL AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="555"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="410"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="567"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI08789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="637" mass="69552" checksum="88E2CFB75731AEA3" modified="2018-11-07" version="1">MRIGCLQFAPQVGDIDNNLNRADAVLSRANADDLTLDLLVLPELAFTGYNFKSLNDISPFLEHSGSGITSLWARTTALRYGCMVAAGYPEKVDVSPKWPTGPEYYNSAIVVNADGETVANYRKSFLYYTDETWALEGNDGFYDGFIPGLGNTSIGICMDINPYKFQAPWHAFEFAMHILDAESNLVIVSMAWVTREDRSVFTRQPNEPHLDTLMYWVTRLEPLIRSENQQEIIVVFCNRTGIEDEVTYAGTSAVIGILDGEVNVYGLLGRGDKELLVVDTTEPPHAKLVYRPEPASAREAEIPNVSPRDGAEPRRSSTNSALSPRPSNDSTSAPRSTRQADTRSSAIPPSEKASPHVTHLGHSTENRSEKRRAANLQVPDRLEVDTESTNIPTPSAPSPTPMALRPRLTSPGSCSSHRSQPSRSEAAVAHGSRESRQRASSTLGKPSSGPHSAPPQGLCESDDPADFYRWPQTRMKAIESFSGGWEVDGRRRKSSFSDGGPVYVTERPSSADSSRNTILHYSRLPRRSSTTGDGGRQGEEFERFEEIVCPDCPVHGRRARSPPPPARSGRVSAPAAESRFRESMLVHAPSSPALEMRRGGGRREAAVEDVSGAGGGGFNPTTPRAMAFAPPERGEVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2Z8</accession>
    <name>A0A367L2Z8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_4698</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2Z8"/>
    <dbReference type="STRING" id="1330021.A0A367L2Z8"/>
    <dbReference type="OrthoDB" id="10267127at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000298">
        <property type="term" value="F:endopolyphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006798">
        <property type="term" value="P:polyphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00144">
        <property type="entry name" value="MPP_PPP_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050126">
        <property type="entry name" value="Ap4A_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42850">
        <property type="entry name" value="METALLOPHOSPHOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42850:SF4">
        <property type="entry name" value="ZINC-DEPENDENT ENDOPOLYPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="2">
        <location>
            <begin position="109"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI08582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="374" mass="41186" checksum="E5E7C1A5E3066255" modified="2018-11-07" version="1">MPSLSMAQQRAIVFAATFFFITSVYLCTTRLFNMSYSSDRSPPPTHRQQHQQHDHRPPVYHRPAADMHLSLADLPMSYGEYRRPGLQGLEKTVASLQGHFVPSSKNGRRLVVVGDIHGMDAELALLLDRVGLDTNRDHVIATGDMVGKGPNSTAVVARLMGLGASAVRGNHEDRVLLSRSEADAASGLLGSQLAEPEDLRRTGQADALAVARTLSMDQVAWLSHLPVVLTADPLPLYVVHAGLVPGVALEKQDPWAVMNMRTLIYPREELRKKQHLEKHDRHSDRAVAVPVENHKGEPWAKAWNRYQKGRPESERRTVVYGHDARVGHVERKYTLGLDSGCVRGGSLTAVVIRATPDGGFGHTTVQVACQKPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L342</accession>
    <name>A0A367L342_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein disulfide-isomerase</fullName>
            <ecNumber evidence="3">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_4809</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L342"/>
    <dbReference type="STRING" id="1330021.A0A367L342"/>
    <dbReference type="OrthoDB" id="10264505at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00238">
        <property type="entry name" value="ERp29c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02998">
        <property type="entry name" value="PDI_a_ERp38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000032">
        <property type="entry name" value="Protein disulfide-isomerase A6 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1150.12">
        <property type="entry name" value="Endoplasmic reticulum resident protein 29, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011679">
        <property type="entry name" value="ERp29_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036356">
        <property type="entry name" value="ERp29_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051063">
        <property type="entry name" value="PDI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672:SF11">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45672">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE C17H9.14C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07749">
        <property type="entry name" value="ERp29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47933">
        <property type="entry name" value="ERP29 C domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016702525" description="protein disulfide-isomerase" evidence="10">
        <location>
            <begin position="22"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="9"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="132"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI08845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="369" mass="40339" checksum="CD7CA025E13C7B48" modified="2018-11-07" version="1">MVSMRTNFLLAALSVVAVASSAVIDLTPSNFDKVVLKSGKPTLVEFFAPWCGHCKKLAPVYEELAFAFQHAKDKVQIAKVDADAERSLGKRFDVQGFPTLKFFDGKSDKPEDYNEGRDLETLSSFITKKTSVKPKKKAEMPSNIVMLNDETFSDTVGKDKHALVAFTAPWCGHCKNLAPTWELVATAYNLDEEVVIAKVDADSADSKKVAEEQGVSSYPTIKYFAAGSKEGVLYEGPRSEQGFLDYVNEKAGTDRVSGGGLGPVAGTVASLDALVAKLVGGDKLAEVAAEVKKEAEKLKEGAQYKYAQYYVRVFDKLSSSDNYAAKELARLDGMLAKSGLAPAKRDEFQRKTNVLRKFVEKVDDLKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L396</accession>
    <name>A0A367L396_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_4905</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI08903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L396"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI08903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="102" mass="11974" checksum="F9E264914AD5F6DE" modified="2018-11-07" version="1">MLNKKERRGTKEEDLQTVRVNVNTTISYSKGYTSKKKKRNHKVRKADADDSSKYFSRYFKVPTCSTLTYLYKIGDLEEDLYVPYPAVSAVLRGVWVRIRPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3F4</accession>
    <name>A0A367L3F4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="7">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_4726</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="7"/>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3F4"/>
    <dbReference type="STRING" id="1330021.A0A367L3F4"/>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08598">
        <property type="entry name" value="PI-PLC1c_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000039">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF82">
        <property type="entry name" value="PHOSPHOINOSITIDE PHOSPHOLIPASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="9">
        <location>
            <begin position="438"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="195"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="374"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="622"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="237"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="382"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="403"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI08742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="728" mass="79592" checksum="17B5B2E7CD216DE4" modified="2018-11-07" version="1">MALCCGLFHRYRSGNNDSTETRPRSRTFSLFGNSDNPASRSQLRSLVGVSILKSGGGEEPAPLSAAMLDVLYGLYDDLCRDEGSSGSLSRDGFAGFLSNVQDEKKKELVGRLDRERYKRGEFLYAWLGCFGIDALAPAPDKDTSKPLTNYFINSSHNTYLDGHQWRSRSSPDPYRAALLRGCRCIEIDVWNGDVGSSRGRGKSPQQGHSSSGALVSVGESVPSRSPSSHDRTLVDDSNNINNNSPRSSFVQCPRDSGALLEVSSAAKSRHQHLLPAVEPIVTHGWTLTTYCGFREVCEAVRDSAFVHNPFPIIISLEVHADLEQQEVMVRIMKEVWRDMLVSEPLAGCDPRFRVPCLEALQGKILVKVKRAPASIKAPPQGHDSASSHSDHGSTSVSDDDRPGGGGGGGGGNGPSRSPTTDNNNNNNNKTKVPICRSLAELAVYTRSERFESLETAQAKKPTHIFSISENRILELWQRQSRDVFVHNKNYFMRAFPAGRRIDSSNPDPSLFWRKGVQMVAMNWQQVDEGMMLNEGMFAGEKGWVLKPAGYRSADKAVDSQDMAAPGRTLDLEFTIYAGHNLPTNSGGGGGGGGGDDVEHAHARSGSTIRPFVKVELHVEKASSSMDSGGGDPLKQRTKAQKTNHPNFGPSGTTIKFVNVAKVVEELSFIRLKIEDESRSGIVSSPLLAWACIRLDRLRQGYRIIHLMNADGNEIPGGKLLVRISKVMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3G4</accession>
    <name>A0A367L3G4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5036</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI08973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3G4"/>
    <dbReference type="STRING" id="1330021.A0A367L3G4"/>
    <dbReference type="OrthoDB" id="5327538at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="462"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="508"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="603" mass="66143" checksum="441C8A9181C64C35" modified="2018-11-07" version="1">MSLASILDSPQIRANVLSHLPPPSAQTLRLTDSHLSSVLTTDVFHRLNLTFTPTKLTRPGRLEALSRIGPHVHHLIFHLDHSSPAAETALPPLVDEATGNVLGFVYAPHTSLADAAARPRWADDRLGVALTTQYPPLFHAATNVVSFIRALSSLPNLRHLTIRCHGPCPVDRYRRTAVDYALVSLRIAIERSPLPALSRLSLERMHPSAFGYLRHGPGGFGCLPSAGRRWRQITKLKLSVQAWDFAGPSPGRDHLRTLDDYLAGFASSLESLSFSWVGEAGPGPCPVVVVGTRPDPTRKLFHELTSTMSPLPTRPGREPVRFPRLRRLTIGNANMTAAQLSGLVASHRDTVVAFDFHQLLLLDGGWHQALASLVSDAAWVSSGLVAAVDADDASSSSSSSSFIDSFVSADDLLPSPSAAVDAVSRALLGGREQQQQQQCNADQWLRDAPTAAEDERTISTSIRKKKKKRIRRHHHRHDGHDDHHHHHHHHHHRHHHHHHSPDDPSLVRSTSTRSKTTTGQLRGTTITAPLAAALPPQLALLQPTVYNPGADDEDEAATGRRHALQRAKEAVLSRLGRDFCRPVEDRGSVESKSAVVPLFFRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3V3</accession>
    <name>A0A367L3V3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Amidoligase enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5026</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI09113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3V3"/>
    <dbReference type="STRING" id="1330021.A0A367L3V3"/>
    <dbReference type="OrthoDB" id="4940520at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847:SF1">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI09113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="418" mass="47485" checksum="79FA2791855B8C2B" modified="2018-11-07" version="1">MSNNTLAHFTLPDLQFGIELEFVSPPMAEPAMLNGKYPTFIHQNLRRQGCFFFLAQLLQNNGLPSAMDLLLTESDCGEDPYRADAPEGTIVGNDLRVMDPSTIPDEKAVVNKQMRFHYWMLKPECDLTHMPQYLMWSETELNSPILPESEATAGFPRVNKALELIATCHEAGVHINERCGLHVQISPVSGLTAQQAKQAVTVVFIIERCLLFHLCHPSRQQAHKPISRARFALLERGLTPGRNEVLDIELREWMPLAFLAVHGNRLRSLWDGSNDLEDISQLLHVRPSSPPKERDRCGLNLNGHYNSKDNWTYALEFRYAQASFNQDFVANWTMLLFAIAKVSGLPAAEFRDVISQLWDVTKVTPKPEDAWRPLLRIIGDAVPREEGIRLDGSYWERRLGDYQSKNYPDVVQGRAVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3W6</accession>
    <name>A0A367L3W6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_4965</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI09107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3W6"/>
    <dbReference type="STRING" id="1330021.A0A367L3W6"/>
    <dbReference type="OrthoDB" id="1936594at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044244">
        <property type="entry name" value="TTC27/Emw1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16193">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16193:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="742"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="466"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="586"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="792"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="885"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="466"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="486"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="597"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="794"/>
            <end position="803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI09107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1048" mass="114637" checksum="8886E9FA79B809DF" modified="2018-11-07" version="1">MDAPSRNPANVLTKDRTSGRRDDGDDDDDDDDDNLAVLVYADVAGELIEAHVSQLVSAADFSPSTLKLPTNDVLAVGLAALDAFLQINVTGPVVPHRLLSAIEERFVGFWKSYGKDGASLRRACLAHLDVDGVSPYSHISHPELFSLARFVLFHALDRQVVETPSSLYTPSEPVGIIAWWRLRVNVWHYKLLTQPSLGSGSNFIKSSQWTDVPSLTSSILDAMDELYARICDGEVWSGWYDNNTTVSRNRQDRPRFLVESATNYILLGYYDKAKERIKEAAQASGFQYALSGALGKRTRFQEKSTSQLLVLARSRRNGLDDDNATTSDDEDAKPDALRLDDDTLLEEIDFAATGDGTGQADDNSLLPPGLADLSLSPKNDQQPQLAPLDQILLLAEATLKDSSSPADTLTSEEVLPFAVRVLADKQTNWQIYTQALLVRSRIELHRSRTVERGVFQLQALADQVMADTSPSGQPTIQVTAPDEASNDGSKTSFTSNTKAMTTTTTTTTTTTTTSFFPAAKAYESAPARVRLRYIHALSTPPRWHLESELAHAWAGVGSLTSALEIFKRLRLWAEVALCLAAAAAAADDDDDEDGDGRGGGGGGGGGGGGGGGGGGGGGGGGGGGGEDVDDIIRLGPDAFTGPKERDPPPANAPRLWCILGDLEDEASHYHRAWSISHQRYSRAQRSLGEWHLRRQDWASAQEAYQLATRAQRSLGEWHLRRQDWASAQEAYQLATSVNRLSPELWTRLGDISLRRGLFQDAVSAYGKALSCSSEAEDARTWSNLGSSLWSLHCEEEEDEEEEEEKRPTRGKGSLVYQSLSAFRRASSLAHDNWRIWENVLTLASRVRPPSATDMILALSNILRIKQSEDAIDIDMLTLLLQQVIPTSSPTPQDDDNTTTTTTTHNQPSPSSQLQSQLTSLLERQVAPLITNRHDLWTLLSDSRTRLQDNATASADAAERAWRTLHSASAANDNGRKDVDVLIRKTIHLVDALERANQPNWRQKSISAVRAVLRRRGGGADDDDDDENLDSDQRDAWLALEEVAQSLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L488</accession>
    <name>A0A367L488_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">allantoinase</fullName>
            <ecNumber evidence="6">3.5.2.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_1401</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-allantoin + H2O = allantoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17029"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15678"/>
            <dbReference type="ChEBI" id="CHEBI:17536"/>
            <dbReference type="EC" id="3.5.2.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nitrogen metabolism; (S)-allantoin degradation; allantoate from (S)-allantoin: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.5" evidence="6"/>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L488"/>
    <dbReference type="STRING" id="1330021.A0A367L488"/>
    <dbReference type="OrthoDB" id="10258955at2759"/>
    <dbReference type="UniPathway" id="UPA00395">
        <property type="reaction ID" value="UER00653"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004038">
        <property type="term" value="F:allantoinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000032">
        <property type="entry name" value="Allantoinase Dal1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017593">
        <property type="entry name" value="Allantoinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050138">
        <property type="entry name" value="DHOase/Allantoinase_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03178">
        <property type="entry name" value="allantoinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668:SF2">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00482">
        <property type="entry name" value="DIHYDROOROTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="10">
        <location>
            <begin position="66"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI09239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="506" mass="53684" checksum="815266D5261DF6B0" modified="2018-11-07" version="1">MAANDIVVLASTRAVISLADGSLALSPATISLSPQTGKIVDVMAELKPASFFPAGTVYKDHSPRLLLPGLVDAHVHLNEPGRTGWEGFWTGTRAAASGGVTTVVDMPLNSVPPTTTVRGFEEKLTACRGQCWVDVAFYGGVIPGNADELLPLVEAGVRGFKAFLIDSGVEEFPAATTGDVAAAMDVLRDSPTTLMFHAEMTAAAAAVAEPGPEPEVEMNDVTAYRTFLDSRPPSLEMRAVKEILSLAARAPSLPLHIVHLSAAQCIPLLREARAQGVNITAETCFHYLGLAAEDIPGGDTRHKCCPPIREAANGDGLWAELLATDSCIRTVVSDHSPCTPDLKLLPQRLGGDAAGDFTQAWGGIASVGLGLSILQTEAKKRVLQQRQQSSSWSIVDAVRLCCQATASQVGLGHRKGGLGKGLDADVCVWDDAAEWSFLSGDMRWKNRCSPWEGHRFVGRVVETWLRGRKIFELGAGGDGKIFELGAGGDGFVVDAPLGEAITERRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4J6</accession>
    <name>A0A367L4J6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ceramide glucosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.80</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Glucosylceramide synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">UDP-glucose ceramide glucosyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">UDP-glucose:N-acylsphingosine D-glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L249_3747</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BCC 54312</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.80" evidence="5"/>
    <dbReference type="EMBL" id="LKCN02000015">
        <property type="protein sequence ID" value="RCI09355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4J6"/>
    <dbReference type="STRING" id="1330021.A0A367L4J6"/>
    <dbReference type="OrthoDB" id="1483400at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008120">
        <property type="term" value="F:ceramide glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006679">
        <property type="term" value="P:glucosylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025993">
        <property type="entry name" value="Ceramide_glucosylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12726:SF0">
        <property type="entry name" value="CERAMIDE GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13506">
        <property type="entry name" value="Glyco_transf_21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCI09355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="476" mass="52519" checksum="340C0E93917FFE50" modified="2018-11-07" version="1">MFPLIETVAFICLIWSAVIVFVQAVGTFAVFRFYSRQPPASVSSKLAQDAPMVTIIRPVKGTDPYLYECLASTFQQDYPSDRVSIRFCVEDDSDAAYPVLAKVIADFPAFDARILVEAQDPALHGPEAYLNLDLGPNPKIRNISRAYREAEGDIIWVIDCNVWVSQGVLGRMVDKLQGLAGGKPYKFVHQMPLVVDVTDLEAKRISPEGGGRLDEMFMATTHVKFYGAINAVGIAPCIVGKSNMFRKSHLDWATTTASQNSVARRPSGVDYFSHNICEDHLIGDLLWRSPMAGFGNHGLAWGDLVIQPMAGVPVAAYAARRTRWLRARKMTVPVATLVEPGVESLLCCGYLSFAMTTLPWFAKLAPPTWKAAGVLWTVLMAGWMAVDYATFRMLHSGATVEVDGRTPRFARGTSQARTPAGWLAAWLGRELMALPVWTWAVLLGTTVSWRGRTFHVNWDASVVDVTTQRGGKDRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4K7</accession>
    <name>A0A367L4K7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000015">
        <property type="protein sequence ID" value="RCI09373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4K7"/>
    <dbReference type="STRING" id="1330021.A0A367L4K7"/>
    <dbReference type="OrthoDB" id="4927915at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="333" mass="36530" checksum="8589C609AC60873F" modified="2018-11-07" version="1" fragment="single">PPWPVASPGSQRQSNPPQQPPSPTPTPTPTSTSTPATAPPRHNETCSPPRNPSTSPPPLPPRTPPRETFMSLADDGYRMVEDELLRTAHLFTIHLHRAEYNRQKTHAKAQHAATILEMERPVVGDPPASARLRAAMRSRDARQRAVLQEGGDLEPLPALRVAGLRRLMDCPRGEDRSIPTSLRTPPVLSNTRAAAGFRRPFVGAHTEPRRRRRSSTSSGSGGGGTAPSRLDPSPPSSGPAPLTEKTCYNGRPDPPAANERATRQQDDGRKKHGTSETYGPDLSDDDDDDDDDDPFSSFKRRRLLRQRARDQQCKPRETGPRPKALPDTIPSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4L6</accession>
    <name>A0A367L4L6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Leucine carboxyl methyltransferase 1</fullName>
            <ecNumber evidence="3 8">2.1.1.233</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_3701</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>[phosphatase 2A protein]-C-terminal L-leucine + S-adenosyl-L-methionine = [phosphatase 2A protein]-C-terminal L-leucine methyl ester + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:48544"/>
            <dbReference type="Rhea" id="RHEA-COMP:12134"/>
            <dbReference type="Rhea" id="RHEA-COMP:12135"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90516"/>
            <dbReference type="ChEBI" id="CHEBI:90517"/>
            <dbReference type="EC" id="2.1.1.233"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the methyltransferase superfamily. LCMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.233" evidence="3 8"/>
    <dbReference type="EMBL" id="LKCN02000015">
        <property type="protein sequence ID" value="RCI09376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4L6"/>
    <dbReference type="STRING" id="1330021.A0A367L4L6"/>
    <dbReference type="OrthoDB" id="203237at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018423">
        <property type="term" value="F:protein C-terminal leucine carboxyl O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016651">
        <property type="entry name" value="LCMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007213">
        <property type="entry name" value="Ppm1/Ppm2/Tcmp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13600:SF21">
        <property type="entry name" value="LEUCINE CARBOXYL METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04072">
        <property type="entry name" value="LCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016305">
        <property type="entry name" value="LCM_mtfrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 8" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="205"/>
            <end position="206"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR016305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR016305-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI09376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="374" mass="41405" checksum="D11A32C2257D23BF" modified="2018-11-07" version="1">MAAPSIPNLLSLRGDGGRRGRNRRGRGDGHDAPPDDISADDAVIQDTDTDAAVSRLSAVQTGYLCDRYAESFVSGPARRRRQPIINRGTYVRTRALDLIISSFLSHDAYAPGRKQVVSLGAGTDTRPFRLLQAHDVIYHEIDFEATCRRKYNTVSASPSLAKSLQDVETAEGGSWSARWCRGGDDDDDDDDGGGGGGEYHCHAVDLRHVDGLDTAMGSTIRTDLPTLMLSECCLCYLSHEESKRVVAYFESRMDRLALAVYEPMPLRDPFGRMMLSNLGARRIQMPSAEHYRDAQGQEARLRDAGFHHVGHATVEKIWDHWVGRAEKARLDALEGLDELEEWRLLAAHYVVAWGTRKIRLEGLDGRGMAALTAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L576</accession>
    <name>A0A367L576_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_3907</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.67" evidence="1"/>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L576"/>
    <dbReference type="STRING" id="1330021.A0A367L576"/>
    <dbReference type="OrthoDB" id="16692at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042995">
        <property type="term" value="C:cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016314">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043491">
        <property type="term" value="P:phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051896">
        <property type="term" value="P:regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14497">
        <property type="entry name" value="PTP_PTEN-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051281">
        <property type="entry name" value="Dual-spec_lipid-protein_phosph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029023">
        <property type="entry name" value="Tensin_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305">
        <property type="entry name" value="PHOSPHATASE WITH HOMOLOGY TO TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305:SF81">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3,4,5-TRISPHOSPHATE 3-PHOSPHATASE AND DUAL-SPECIFICITY PROTEIN PHOSPHATASE PTEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51181">
        <property type="entry name" value="PPASE_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatase tensin-type" evidence="5">
        <location>
            <begin position="12"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="4">
        <location>
            <begin position="124"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="281"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="457"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="551"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="288"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI09574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="584" mass="62528" checksum="9BA11B6206FAA2D9" modified="2018-11-07" version="1">MASILRQIVAGPRSRHPEAGLDLCYVTDFIVTYPQRAYRNPLDQLVSFLDSKHGHDWAIWEFRAEGTGYPDDAVYGRIRHYPWPDHHPPPFGLVPLIMASMRNWLGGGSLDGSQESGGEKAAGSGRVAVVHCKAGKGRSGTVSCSYLISEAGWTAEEALARFTERRMRPNFGAGVSIPSQLRWISYVDRWTRHGKKYVDCAVEIIELQVWGLRNGVKVNIEGFVDQGRTIRPFHTFPRHERLVVTSGAPAGEGIGQAIWDIAGYPATSAVEPAPEAANLADAANAPQKQPPHPPPPPSPPPPLPDRPGTEPAAQQLRTREKLIRKGTDLIQRGPKSSENNGPPPSTARVEPSEEPDPGGMAVIFRSQEPIRLPTADVNVSVERRNKTSKSIGLTMVTAVAHVWFNAFFEGQGPEQDGRPSESGVFTVDWEAMDGIKGSSRKGARALDRLAVVWRLAVTPSSSSSPSSPPPSSSSSYPPNGKVGGRGEDIPVPAVGQPVPQLKAAAECEPMVVVAEPDLGFRKQSPASADVSRASSYRSDVEVKDAAAAAATTVGGTNDDDAASMRGVRCSDPSGEDLLLPEGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5G8</accession>
    <name>A0A367L5G8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_3841</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5368485at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22584">
        <property type="entry name" value="Rcat_RBR_unk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482:SF62">
        <property type="entry name" value="LIPASE ROG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="12">
        <location>
            <begin position="285"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="289"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="899"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="947"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1044"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1101"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1344"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1480"/>
            <end position="1537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1575"/>
            <end position="1676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1742"/>
            <end position="1943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="25"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="954"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="975"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="997"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1049"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1106"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1362"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1415"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1512"/>
            <end position="1524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="1590"/>
            <end position="1600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1606"/>
            <end position="1615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1616"/>
            <end position="1634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1644"/>
            <end position="1674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1749"/>
            <end position="1763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1766"/>
            <end position="1776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1799"/>
            <end position="1810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1825"/>
            <end position="1840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1861"/>
            <end position="1878"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI09675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1984" mass="219982" checksum="0CFFA541518D823F" modified="2018-11-07" version="1">MSSDRHREVDDGHERSGRRRRYRSGPHDWKNAAHRLAHDDAAVCDDQLRDAAAPPPPPPQARASMDAYRRPDRCMSYDDRRDRVAERSGRHVSSPGYARRDPAYSSGYGDGVGDDDDDDIEVVEVIEEDGGSSRHRSGHHSSREDYMPSSGGRRRRRRTRHADQDDDDGETAVLHGRRSYGSPTRESSRVVDRSESSRLGSRHQQVVDVIEDSRPPVSSSKRSTLRRRNRSSDSQDRPRASSATRPSRSRSGSMSRRPSGILETLFGSSSTRRASPEERHVKAARRLECVVCMESMSPSRAAKLKCGHAMCRACLERSFKLSLTDPQHMPPRCCTQEHIPLRHVERIFDDSFKAAWNRKFAEFSTKNRLYCPSQRCGEWIKPDAIRREDGVKVARCDRCRIKVCVSCHGKWHGNAECPQDEETARLLAQAQAEGWKRCYRCKAIVELREGCNHMTRCGAEFCMICGSKWKRCDCPWFSNDGDVRDVPVPQIRGDLHDIFRGEGPPTPAELRNQHPVTMTLPTRPRSYHEEKLMRRLQGQRDEELARHLQYGGDAYDDGHGMMGGIGDIHGVGNAAGHLMNEDYRGGGRLPARTGEYGPVERRLADRLSETPRVIRMSPETVTVRAEQVVPRLRQHSLEEELYDHRRPRASRRTERVVGGRLSRRYEDEMFVHAPRRRIEEEAKASPPRSSDMAGLNGYGQGMNRVSQWRSFVEPGIPDGESVDGHAPLPPLSLGGMLLLHQVGSVKIGEVVRYTVTYTPSQDRILPASERLHVRIRNTSTIVRRAAFVRGPYTLSVSAHPAGFDANSTFTDARRCGVPVFEPMLKAGGSWECELVVPEDIRSTAGAGFAGETGDAESASWIIEVASQVIFSPSVSVGYELVVARDAKSLNLTSSAMSVGQSQLPLPGRVSDQQQSIGAKDGHHPAQPRGVFSRAVHLKVEDTATLWNTPRLPGWDDDDDDDDDDDDDDDDDDDDAGRQSREQPVETDAHHEEAHEREKKRRRRRKKKKEKRKVHLVVLTHGLHSNLGADMLYLKESIDAAAKQAKREADNDDDDDDEQVIVRGYSGNATKTERGIKYLGKRLARYVLSMTYPDQPLIPIGKGSGEGFSQANTTTANGQNHHHSHQKPDSDHVPAHKHSSIQTDALLESRIRAQRPFTITSISFIGHSLGGLVQMYAVAYIQKHSPQFFDLIKPVNFIALATPFLGLSNENPLYVRFALDFGLVGRSGQDMGLTWRAPTIARSGWGAIVSNLGESAHRKVYGDTVPESKPLLRILPTGPAHTALKKFRNRTVYSNVVNDGIVPLRTSCLLFLDWQGLGRVDKARRDAGLVQTVVGFGWAELTGTNMLTSRPRQQPPGGGGEAQTDSGSSTPRGTMHQVPQPMPGEATDEDDRASIRALPMPHHDQADGQVQGASGSSKNNNNNNNNNNSSNNNITNNNNNNAGGPLAGFFKFFQSSNNEPAKEKNLSQKQKMILRRGQTMPLDQAPIEPADGYSSSSSSKADNNIMTKTKKEEKKKKKKKKKKKATAMDDEQIGIMKAPPRTTLFESAGDLLNPSLPDADYLVDPSKRPRAIFHDRIYHPSDIPPPPPAPPKRRHSSRRKATASEKTTTTTTTTTTPSSDSSPFAGNGTKTPSAEDSSDAVAVENNSSGSGSSSNNNSNNSNNNNNSRSSSSSSSDVIRVEEKIARGYHRDLSWRKVLVKLEPDAHNNILVRRKFPNAFGWPVIKHLVDAHFSVDAPLHATDEDVQTGERALDPSRPPDEHGVETLDQMTTTTTASSEARDEVADLPPPQPQPIVRKAQDEDDDDDDDDDEKAVTSSCTPSAPFRPPERADSVTWSERDWQDSDAESDAETGPKKRPSLPLAPVNNSNSPCSPCAPHPSASKDESKNIKSLPKVASQHQHKQRQTSSSSTSSWNWTEKIVGKGVRGRSMSPKPQQGQGVEGGRLKSAFPPFLLRLNEAKGQTSPKNRLIDVFPIYPNHRIPTFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5N5</accession>
    <name>A0A367L5N5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">L-2-hydroxyglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="7">1.1.99.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_4073</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>(S)-2-hydroxyglutarate + A = 2-oxoglutarate + AH2</text>
            <dbReference type="Rhea" id="RHEA:21252"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:16782"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.1.99.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the L2HGDH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.2" evidence="7"/>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5N5"/>
    <dbReference type="STRING" id="1330021.A0A367L5N5"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047545">
        <property type="term" value="F:(S)-2-hydroxyglutarate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43104:SF4">
        <property type="entry name" value="L-2-HYDROXYGLUTARATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="11">
        <location>
            <begin position="319"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="128"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="214"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI09734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="722" mass="77568" checksum="78C17FFFF035E603" modified="2018-11-07" version="1">MAANNGCPESPAGSPRSASVSLQAAATMNAGLQREPSRQSSSSSLARNATPSSPQTGRRRSAVLMNLHLNDPAIPAPGEMMHDPHQPHPNHHRAPSLGELHQELEAEQEAHVNRLLHMIRQQQFELQRLQAGRPAQPSDDDAADRHAPLPSTGSVGSYPRSPLDNIARADVHNRRSRTPSRGASPRLRAASISADSGDWVLGGRDESAFYQAETQMLVRENQMLRHRIRDLEKQLTDLSVVPTEPAIPSQLTHSSTAADELEKESQSAIGAAAAPLRSLPSAVGLRTWRKPLSSTAAARADFTHVKVNRTDAESGQAKVIGGGVVGLAIARQLSLRRKDRSASSSSSSSSSSSATLLIERHGSLGTETSSRNSEVLHAGLYYGADSLKAKLCVRGQRLVYDFCKRYRVPHRRVGKWIVALDRAQREALEDIYALATRRLGLTSLRWLSQDEIRSRGEGVFAPAGALESSDTGIVDSHGLMTSLRALFEDGAGSTVALMSTVVGVEPIGSRASDGWRVRVRGGEESEASSCETTIATETVINAAGLEAVNIHNLIAPSDSHHRPLHFAKGSYFSYAASKPRLSRLVYPAPSPASAGLGTHLTIDLAGQMRFGPDVEWVDSPHDLTVSPGRLSTVARDVRRYLPGLDPSRLVPDYAGIRPKLSRDGAATVAGGASNLQDFVICKDDRYEGWVDLLGIESPGLTSCLAIAEMVEELLYGTVTTAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5P0</accession>
    <name>A0A367L5P0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4076</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5P0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="399" mass="44115" checksum="8F09CC0071AC7ED5" modified="2018-11-07" version="1">MYSQQARASSLEEGLRNRGREGVTVSEDEEDEGTRRRHRESRRRKEAIHAFLARLESRVMRAFLSFRRYGAVSRLAAGSGRWRAGTRDLATDGAASRLISQISFQCTAGKLDPDYNADAQQEIGSVPGTVARAAAGDKLKVASTFAGAPRSLAQPTSSQLACTLYGIAGATPCSRYLLRLAHAPGPPSLDLSLSLALSFSPLFALSLFHFFFPPLSLLSIGTKLHSAAIDHSQLLHARAPSLPPNKARKQKQQRKKIRLRSFFLLEPSAPYYHYYDCHYHPVLLAVSGKGPTLPTSIHSNRHQQKKRKENGPASIAALNTSKVIKPNTYTSLIRTSGIIHTAWCPLCAIARRLSHPSLSPSLCHTFSFHHHHHHHHHHLFLTSISTHLFRLDSASRACT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5S4</accession>
    <name>A0A367L5S4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_4156</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5S4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI09785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="176" mass="19989" checksum="F466E15FA60956AA" modified="2018-11-07" version="1">MYMIYVPDLFPFRPIRGAEEPLARLGQSPANREPGRERNPAPESLARTGRSISFFFLCRIRIRSLLFSSLLFIMLYFDGFFAGTNGWMRSMDGDGWMMSRMVARLGRHVTARKLYLTAYLHTMANVVAKETPLRRIPIQGSLPARAEVATNSATYPPRTFSPERSLRPGQPPFSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5Z4</accession>
    <name>A0A367L5Z4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_3813</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5Z4"/>
    <dbReference type="STRING" id="1330021.A0A367L5Z4"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11651">
        <property type="entry name" value="YPK1_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000008">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000048">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="294"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="550"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="13"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="90"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="91"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI09844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="638" mass="70932" checksum="C91CE73D47185B0B" modified="2018-11-07" version="1">MSWKLTKKLKETHLGPLSAFSRSPSTSTITDKDEKTQIATGVTTPTTENAIAASEAMTQAPVVKPPKPGILVVTLHEGQGFALPEQHRNAFASQHQGSQSSSNAPNLSGSVRPSSSQRPAAPFVNGSSRPHSSAGGFGGIPTNHGRISGKYMPYALLDFDKVQVFVTSIDGNPENPLWAGPSTQYKFDVSRVTELVIHLYMRNPTAAPGSGRSQDIFLGVARVNPRFEERQPYVEDPKASKKDREKAAAEHAQRQKAEGLSGTEWVDVQYGCGKIKVGVEYVETREGKLKIEDFELLKVVGKGSFGKVMQVRKKDTSRIYALKTIRKAHIISRSEVAHTLAERSVLAQINNPFIVPLKFSFQSPEKLYFVLAFVNGGELFHHLQKEHRFDVNRSRFYTAELLCALECLHGFSVIYRDLKPENILLDYQGHIALCDFGLCKLDMKDEDRTNTFCGTPEYLAPELLMGKGYNKTVDWWTLGVLLYEMLTGLPPFYDENTNEMYRKILSEPLHFSDVVPPAAKDLLTKLLNRNPEERLGANGSAEIKAHPFFHAIDWRKLLQRKYEPAFKPSVVDALDTANFDPEFTSEAPQDSYVEGPVLSQTMQNQFQGFSYNRPIAGLGDAGGSVKDPSFVGSMQDNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L645</accession>
    <name>A0A367L645_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI09906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L645"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017008727" evidence="1">
        <location>
            <begin position="20"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="66" mass="7258" checksum="C32B6AACB7A5338B" modified="2018-11-07" version="1" fragment="single">AKSSLLLLFRFTLPGLYITSRIPPKLIPDLISTSNLTIKLDAASVVRPIVRADLTLATPNAPRIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L671</accession>
    <name>A0A367L671_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">pyridoxal 5'-phosphate synthase (glutamine hydrolyzing)</fullName>
            <ecNumber evidence="3">4.3.3.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_8619</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by PDX2. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Also plays an indirect role in resistance to singlet oxygen-generating photosensitizers.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>aldehydo-D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + phosphate + 3 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:31507"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="4.3.3.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; pyridoxal 5'-phosphate biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the PdxS/SNZ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.3.6" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI09923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L671"/>
    <dbReference type="STRING" id="1330021.A0A367L671"/>
    <dbReference type="OrthoDB" id="1660966at2759"/>
    <dbReference type="UniPathway" id="UPA00245"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036381">
        <property type="term" value="F:pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042823">
        <property type="term" value="P:pyridoxal phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04727">
        <property type="entry name" value="pdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000001">
        <property type="entry name" value="Pyridoxine biosynthesis protein PDX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01824">
        <property type="entry name" value="PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001852">
        <property type="entry name" value="PdxS/SNZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033755">
        <property type="entry name" value="PdxS/SNZ_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003215">
        <property type="entry name" value="PRK04180.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00343">
        <property type="entry name" value="pyridoxal 5'-phosphate synthase lyase subunit PdxS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31829:SF0">
        <property type="entry name" value="PYRIDOXAL 5'-PHOSPHATE SYNTHASE SUBUNIT SNZ1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01680">
        <property type="entry name" value="SOR_SNZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029271">
        <property type="entry name" value="Pdx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01235">
        <property type="entry name" value="PDXS_SNZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51129">
        <property type="entry name" value="PDXS_SNZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0704">Schiff base</keyword>
    <feature type="domain" description="PdxS/SNZ N-terminal" evidence="11">
        <location>
            <begin position="15"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with D-ribose 5-phosphate" evidence="9">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR029271-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI09923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="305" mass="32042" checksum="156F90594BBE580D" modified="2018-11-07" version="1">MADVVTVNGSKSSMVVKTGLAQMLKGGVIMDVTNPEQARIAEEAGAIAVMALERVPADIRRDGGVARMSDPAVITEIQAAVTIPVMAKARIGHFVECQVLEALGVDYIDESEVLTPADDSSHVDKTPFGVPFVCGCRNLGEALRRIAEGAAMIRTKGEAGTGDVVEAVRHIKTLNRDVGRAREALAAGGMPRIRELARELEVDAELLRQTAELGRLPVVNFAAGGVATPADAALMMQLGCDGVFVGSGIFKSGDPAKRAKAIVRATTHFKDARVLAECSTGLGEAMVGINCDAMRPEERLAGRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6F0</accession>
    <name>A0A367L6F0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_8657</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI09979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6F0"/>
    <dbReference type="STRING" id="1330021.A0A367L6F0"/>
    <dbReference type="OrthoDB" id="2133190at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052099">
        <property type="entry name" value="Regulatory_TF_Diverse"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47336:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR HMS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="3">
        <location>
            <begin position="401"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="45"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="104"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="353"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="458"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="384"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="396"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI09979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="517" mass="57251" checksum="AABC02DC9A3B5D7A" modified="2018-11-07" version="1">MRLGITTPYFRLATVFQLRATTIGWRCPLGPAIVYQHQQQQQQQQQQQQQQQQHQHHQQQQHQQQHQQYQLPPPATAFDFSADDSMPSFDPTIAAFTDMSFARPAAGPSSSLRDDGSLPPPQRQPDCFRRGNNLHDKKRIKVDPDTPTLDSMDQWIRFDDDADKMGSFEIDYSKRNDLAGQNGTCATANTMPGLGTGLYSTAMAPFREEDFIDDAAFDDQILSEDDDVFDTTQLPTTQPLQAVPPASLPPPVPPEKIVFGPPSLPWAAKAQPGPRLNLDMGETPRQMRRDLWAALPRGVSQILSPDEQRRLLEIALNSGQMPGSFIPPNGFGIGFGAGLGARLSAELDRRPGVVETTQQGTSLRAEELQDASLKHPKRLAAARSATSKRQSAPETGKPRSADRIAHNDVERKYRTNLKVKIAELRDAVPALQSLAPGTDAEGSSGNQGAPKVSKGTVLTKATEYIQQLEQKNKAIMLEHQQLARRLQAFEALFNSVSRQPDLMPNHSMTLFDPRGFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6G9</accession>
    <name>A0A367L6G9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_8670</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI09999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6G9"/>
    <dbReference type="STRING" id="1330021.A0A367L6G9"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI09999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="579" mass="64794" checksum="7B3F85F65B451BB0" modified="2018-11-07" version="1">MATDGSHYDFIVVGGGTAGNVVAGRLAENPDVSVLVVEAGIGNPRENTDIMTPALAMDLRGSEHDWQYKTTMVRRDDYERIEKPNTRGKALGGSSSLNYFTWIPGCKPTFDMWEEYGGKEWTWEPLVPYLRKSGKYHDDDNLYSPDLKKIGPDGLLPISHCELIEEMEPFRENLIKAWKSRGHEMSEDIYDGEMKGLTHCCASIYHGRRSGSWFFLENKPKITVCAEATSKKLIIDKADKTCKGVTVIKGGKEMSFFADREVIVSEGVFETPKLLQLSGIGPADELKKHGIEVIVDSPHVGEHLLDHPGVPFVLQVKDGFGVEDELIRPGPKHAAAVSKYEKGHAGPMGSGLLELVGFPRIDDYLNKDERYRKAKEANGGKCIFSPQGQPHFELDFVCMFGKSFQWHYPIPKEGNYTTVMVDLVRPVSEGGTVKLRSTDPFQQADINLNFFANDLDIIAMREGIRFTYDVLLNGEGFKDLVVKQYPWDMPLDDDKAMHHAVLDRCQTSFHPCGTARLSKDVKQGVVDPQLKVHGIKKLRVIDASVIPVIPDCRIQNSVYMCAEKGADQIKAEHKDLYNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6Q2</accession>
    <name>A0A367L6Q2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_8411</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the THADA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367L6Q2"/>
    <dbReference type="OrthoDB" id="73997at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056843">
        <property type="entry name" value="THADA-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056842">
        <property type="entry name" value="THADA-like_TPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019442">
        <property type="entry name" value="THADA/TRM732_DUF2428"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051954">
        <property type="entry name" value="tRNA_methyltransferase_THADA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387:SF0">
        <property type="entry name" value="DUF2428 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387">
        <property type="entry name" value="THADA/DEATH RECEPTOR INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10350">
        <property type="entry name" value="DUF2428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25150">
        <property type="entry name" value="TPR_Trm732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25151">
        <property type="entry name" value="TPR_Trm732_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26523">
        <property type="entry name" value="Trm732_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA (32-2'-O)-methyltransferase regulator THADA-like TPR repeats region" evidence="6">
        <location>
            <begin position="231"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2428" evidence="5">
        <location>
            <begin position="632"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA (32-2'-O)-methyltransferase regulator THADA-like C-terminal TPR repeats region" evidence="7">
        <location>
            <begin position="860"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1418"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="564"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1431"/>
            <end position="1446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI10101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1531" mass="171700" checksum="EEF6FD86C2C290DB" modified="2018-11-07" version="1">MEPGFIEPNSLNEQATVEWLETQDPGVQKSQAASLFARLLEEAKNPKSTSGQACPRLAGLVSKSLGSSSNQLRDWAFSKSVTLDLFHFYIDWDDADRHRSVKLLLDLIAQSVIKNPDRDEGTQTKQCIIDSLISTVTGRAVKPAAKSAMTCLDYFIKSGTLTLDDVFFSYSTYRKEPVQLNRCQVWRHFITDLFRWMGLHFVSLSAGRLVVSIYRCWRQENRQALEVPSVETWFEWLVGFACQDPILIDPIKNYILFPLFRDDRLEGLRFLDKINEAVSTHQHIDKTVFHLAALESGTRAGLVECSSSKSGCGQGNELPSLTLSPSILGEFLAQPDERVRILSLSVLVTSPSTTAPYTIDALKILRTHLSSLFSETNARVREQTSGKLRDMFRRLRGAIHVLTRSTSRSMVCSRIAVQLTECLEYHQDFLHFYMAFLCNELVPTASYQRHIASLKAANFILRMEAEAARKWKMREQLLVDFFDDKWMRALFDLLMDPFDDVRDGAATALKRLYIDFTTVDKVETPRTADAVVEVSRRAEELARRTSRADHSDGSSRVAQLHFLIQSAEEQTSCLKQKVRQLERKVSGAEKDLASAVLYEPLHGDLASLNRLWQVTMELKLSQPQLDAVTALQLDMVSLCERVWKAVRDVLCYDSPEGHLPHELEEVEGLETKSLLSFSFRAVNEASNLLRIMVLTTRNGVRNDFVSPTREVFERIGAFAFDQLASLRHRGALTTAGLLFATFCQQAKKMDTDLDMWYQEALRLIFSVTSTTRRSAGLPTIITGLLAANAHPSFEQIMDKLISIASLKVQGTGGLPQVHSYNCLREIFKVSSTNGRQWEEYLSPCLQLAANGLRSDVWAIRNSGLMLLRSLVDCLFGSHESKAMIETGWDGKANRLAYHRYPGIEAGLRDVLVSGHETLEGGISVLEIIRRGGPPESLRDEIEAEVQEYLACSFWQVRELAARTLSSCLLSNRRQWLPFMQGLFEKALEEGDPNLVHGILLTFKAVIQRLSEVAVDRLEVECPILTTLLSRYSIETRFVHCSDVVAAYVQVLNTVWSVQKANSRKPTPLAPIYPRQNHSIKGSVLLGKSTLIHKVYAAAASFQDDSIKQLRTLLLNQPAEVDTTSALREMADLFHSTASEQTVAELAELYVELCHRKSPAQTEALHSLIASLETLLGRGKTDMVPTRSVKKLWHHLCSQPIGPSLSYQIIRLSATIAILNGPPSLPAWAEMISEAGQDHQPLDSRLAASHALHSFFFFSSSSSSLAANPPINLDDETSLPALLALYDALSDDDEEVRAKAASAVQSVIQDQNTTNLVVPIEASRRLVNWLANHHGKSTTFKNEVADRIVGHKATTTIIKEDGSTTGWKPASQLLQTAKEEEEKFSLFATEKQNLYFEEIRETKSWLPFLPLLLPLRHHHHTQSQHTQSSHPEEDDDDDDDDDDEPSDALERLTGWLIEGLPHLGQMGQDGPLGWSSKPRVFAICSRLILASVALIRLRPSPALCEAARDARERLRTRDVSRLLTDGWEDASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6Y1</accession>
    <name>A0A367L6Y1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Tyrosinase copper-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_8662</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6Y1"/>
    <dbReference type="STRING" id="1330021.A0A367L6Y1"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF131">
        <property type="entry name" value="TYROSINASE COPPER-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016950339" description="Tyrosinase copper-binding domain-containing protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="3">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="289"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI10190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="555" mass="62036" checksum="C08FB13CDB8D36CA" modified="2018-11-07" version="1" fragment="single">MLPNNIALWLVALGSAAVAPVAADHVAVTGVQGDFRRAVPLRLNINDLQARGGPAWDLYLLSLQAMYETNPSNTESFFQIAGIHGKPYREWNDAGPQESDGWAGYCPHGEKIFLTWHRPYLALYEQTLIKHAKRLAATYPQQVRAQYQQAAENLRIPYWDWAAQQEVPGATVPSRVRVNSPTGSKQIDNPLSTFKYPRSVLSGQFGAWDNRPQIFHCPSPYKYPDSANSNLQSRPYKQWIYDALTRSRSFDEFASPEGGGVGLEQVHNAVHWDASCGGQFLALDYTAFDPLFMMHHCNADRMWALWSAMNPGSVIFNNTYRGGSRFSTPSGSEITPDSPLQPFYQTNGRFHTSRSVSSVKPFGYSYEGLEYWAKSEATMRQDTVRLVNRLYSANSFSSAGMMSSQRPEVRYFVNLELDMGQVPRPCQVNVMVDGKYAGNMVVMSQPGKGIMKGGFSIDKATREAGLNRLPREEAVKKIQAAIKVTIVKGDGSTMSVDKVPSFKLELESINYTPAKSDTGLPKFDNAKMHSVKLPSLLNFFFNYLSCVHPLFFQPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L737</accession>
    <name>A0A367L737_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L737"/>
    <dbReference type="STRING" id="1330021.A0A367L737"/>
    <dbReference type="OrthoDB" id="5396420at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="367" mass="40709" checksum="263193672E266C72" modified="2018-11-07" version="1">MPSRRRPLLLFRRPPSPPPPPPPLPRLRLRALSSRCGPERVDVRCGSAGHVSVHLFNGAHDARNRHALVIHLPSSPTVDDAAAPLPAFLQHLPVAQINYRWGGADSRALHWPTPVHETSFAYAWLHANLAPPSNGGRDMFVFGSHLGASLAASLALTETHDDAKFGIRGLVAYNGIYNWTMFMPEHRINKLASKTSPSVQKLQSRLPSLFRRPSDLLDPFASPSLFFHGPGLLAPRWFASDDDNTVWDQDEQAATVSLKPPRKSMTVFPPPKSSLRIPETFLLHHDGDGTKAVGHSLRSQARELALLMRRSIVESEKRATVEWDEKEDVDVADEEAQMRVQAVDAGPLADDAGFMALDWMRERTDAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7I5</accession>
    <name>A0A367L7I5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_4433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7I5"/>
    <dbReference type="OrthoDB" id="5391496at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI10388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="237" mass="26277" checksum="92CC59C313B2DA7F" modified="2018-11-07" version="1">MQIALGWIMETSLEPQLSHQPIYLAPATPSELLDRVLSHHTYPTTLLVCWPKKLFLDGLIQEVRQQISSASSSSGQDGHGHRHPLLQTPLLQAAVSRHLHLAFIPTVAHLRAYLAVFLTRNMTTPPPPADFRPSPPRQVPLLLAYGFVELHRDGSEWSAQGLNMSAAGLVESAARNGLRAAVVEPRKTDGRDEIWTTLDESVPLLSGSTSIRFDKVPVRAVFSRWFEFESPRGVPSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7K2</accession>
    <name>A0A367L7K2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Protein kinase C-like</fullName>
            <ecNumber evidence="2">2.7.11.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">L249_4437</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.13" evidence="2"/>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7K2"/>
    <dbReference type="STRING" id="1330021.A0A367L7K2"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004697">
        <property type="term" value="F:diacylglycerol-dependent serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20822">
        <property type="entry name" value="C1_ScPKC1-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20823">
        <property type="entry name" value="C1_ScPKC1-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08689">
        <property type="entry name" value="C2_fungal_Pkc1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11620">
        <property type="entry name" value="HR1_PKC-like_2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05570">
        <property type="entry name" value="STKc_PKC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000101">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000103">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000014">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000034">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.160">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037778">
        <property type="entry name" value="C2_fungal_PKC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011072">
        <property type="entry name" value="HR1_rho-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036274">
        <property type="entry name" value="HR1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037312">
        <property type="entry name" value="PKC-like_HR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02185">
        <property type="entry name" value="HR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00742">
        <property type="entry name" value="Hr1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46585">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51860">
        <property type="entry name" value="REM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="REM-1" evidence="22">
        <location>
            <begin position="130"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="20">
        <location>
            <begin position="432"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="20">
        <location>
            <begin position="500"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="843"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="21">
        <location>
            <begin position="1103"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="73"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="338"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="571"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="666"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="776"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="351"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="590"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="633"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="666"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="691"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="746"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="776"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="872"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00068745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="RCI10391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1168" mass="131089" checksum="89C7F63E88756F04" modified="2018-11-07" version="1">MKDDEAIRSIQAKIEREEALMTAAINMRSLPINEGHRSRIDSELRDNERNIKFFKEKLEAIRQRQVQQDLGAMALGDEPPYPPPKDNVAWGERASHHGDSMPSRHPFAPPAPGAGIPKPRPNFTKLDLIKYDTPHLGPRIQLMLSQLQFKLNVEEQYLKGVEKMVQLYGMEGDRKSKADAAGRRVESKQKIVLLKQSLKRYEELHIDMDSADTQDDDSINTPNLRKPLSGMLTIRCMAVKGVDHAATGRFARGPETFVAVKVEDTVVARTKASRNDRWEGEQHTIDVDKGNEIEVTVYDKPGEHPIPIGLLWVRISDIVEEMRRKRIEAEMNFSGWVSADQHKPSSPPSQFPMSPSQGPYIQGQQGQPGGPGPQPQVSVGPIDGWFNLEPTGQIQLQLSFVKQNKDRRKQDPGLGRKGAVRQRKEEVHEMYGHKFVQQQFYNIMRCALCGDFLKYSGGMQCEDCKYTCHNKCYPSVVTKCISKSNAETDPDEEKINHRIPHRFQPFSNMTANWCCHCGYMLPFGRKNCRKCSECGLTSHAQCVHLVPDFCGMSMAVANQILEGIRIHKQRQAKATSMTDRNLRAGTGKQAQSSSASHASSASYSGSTPPLYGQGPASSEATEAAKVMYGSQTSPQRPAQPSRASSSQAVSPAASAAATAAANAAMSGSMAGSGSPGRQPADYSRHSGGYEQQPQQQQAPQQQHYDDAYAPGQHHGGPPPPHQRKYNPADYANFNAGYAGQSSGSRPQSQQQQQQQQQQQQQQQQQQQQQQQQQQQHQQQQQLQHPHHPQQQLQQPSYPASVLMPKGDSLPGQRQSSGSAVGQRKQLPLATDPGTGQRIGLDHFNFLAVLGKGNFGKVMLAETKRSRKLYAIKVLKKEFIIENDEVESIKSEKRVFLIANKERHPFLTNLHACFQTETRVYFVMEYVSGGDLMLHIQRGQFGTKRAQFYAAEVCLALKYFHENGVIYRDLKLDNIMLTLDGHIKVADYGLCKEDMWYGSTTSTFCGTPEFMAPEILLDKKYGRAVDWWAFGVLIYQMLLQQSPFRGEDEDEIYDAILADEPLYPIHMPRDSVSILQKLLTREPDQRLGSGPTDAHEVMSQPFFRNINWDEIYHKRVQPPFKPSIKNATDTSNFDSEFTSVTPVLTPVQSVLSQAMQEEFRGFSYTADFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7L5</accession>
    <name>A0A367L7L5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_4410</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7L5"/>
    <dbReference type="STRING" id="1330021.A0A367L7L5"/>
    <dbReference type="OrthoDB" id="2593732at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF4">
        <property type="entry name" value="HYPOTHETICAL CONSERVED PROTEIN (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="45"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="84"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="290"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI10418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="301" mass="32294" checksum="D9C5A7B44E9FE962" modified="2018-11-07" version="1">MSGDTVPTAALGINRSGNHDCRANASTTPRQRRATRAKFSKVRTGCVACERRHIKCDEAKPYCRNCIKWAGFCSGYERRDGDTTMEASAAVPYQQPPPPPPPPPPPPPPPPPPSPSHDGCILDDSFWTESVPRLIRESTALRWANSAVQALVQAKKSSSGHHYNLALTHYGQALQAARQAVSAQRQADLREAIACSIFFVVFEAVNGDLPTAEAHLVNGQRLLEGLGSPPHSLRHQVGHVVRLVGAQGSRQMGDLAAFVGCGGGGGGGGVRPKDERGRIRRRLLAGAEPSRAEPSRGRGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8S8</accession>
    <name>A0A367L8S8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ABC transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_4464</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367L8S8"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000055">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000066">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000838">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF399">
        <property type="entry name" value="ABC TRANSPORTER ATNG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="64"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="263"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="393"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="506"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="921"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1053"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1157"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="284"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="636"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="1038"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1251"/>
            <end position="1482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI10632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1490" mass="165337" checksum="770C9385D5DE192E" modified="2018-11-07" version="1">MSCSISAEDRFGPVVADSCLGGFDFTLLFEESILTLVPLAVALLWAASRALTLRNEPSKVKASWLIAAKMLVYFVYVILQVALLAVWVARGVPQTRLTVACLALTIASYVALSLMSYMEHMRSVRPSSLLSVYLSISLLTDMARVRTLFFMPESTTLAAILLASLLLKLVLFGLESTEKRHLLREEWKYVSPEDTSGFYSRALFVWLNAVFRNGFRTLLTIATLTPLDDEMLEASNPTKLIERWEKADMRLHRRLAGKSSQHSLTWTFLVHYKWVILSGVIPRLAYTGFSFSQPYLIQRVLDFTTQPENPNTNNISYGLVGAYAIVYIGLSLSFAIYQHKTYRLLTLIRGSLVTLIFNKTLRVSSASIADGEAITLMSADIDRIGAITMIHEFYASFIEAAIALWLLYSLLGIAVLALAPPAQVKRELVDLSPVCLVGGIPLARAAGNAQTPWLEAIEERLAATSKALNSMKPIKMTGLADIVSSQLANFRMLEIRASLRHRVLNIFVFVAYFASSGLAPVWGFGVFILLARSRNTGTLTESTAFAALSAFELLNQPMMNAIDGFEHVQTVLNSFRRIQEYLLSEEREDYRISGLARTPSDSDVSKTQVDEKMAIKDISDSWPEPPRDDSTTAAVVTDASAQYTEEGEPILRKLSFEVRRGKITMIYGPVGSGKSTLLKLLLGEMPITSGTVTANFSKAAYCPQTPWITWGSVQQNIIGMSSFDNAWYDTVVRACALLPDFDELTNGDKTHAGIRGARLSGGQQMRVVRNIALAAWPHSFARALYSRNATMILDDVLTGLDRATERTILDAVFSPQGLLRQQQSTVVWTTNSAHHLSYADHIICLDKDGKIAEQGTLDNLSIGAGGVQTLSSQPIMETSRAQEMEIPEDALHELEILEEQEPEETRRAGDMRIYAYYAKTAGWWTTSIYLVACAAFVYGAIFPSVWLQWWTNANAERPNERIGYWLGVYGVLAAKLSTHPKPLSVFNLAVLPTTARKFHELLLGTTMRAPTSFLTSTNAGTTLNRYAAGWGSVFQDCDLELIDNDLPMAIDQTIFQFFSVIASAILVFIGSGYVAAAIPFVFVALAVIQFYYLRTSRQLRLLDIEAKAPLFSQFLETLNGISCVRAYGWSHRYEDRNHEALNASQRPFYLLWCIQRWLTLVLDLLNAAIAILLVGIATNVRGGSSAFLGVALFNVIALSSSLQTLITEWTQVETALGAIKRIRSYVLTVQDENLPGEDGPVPDEWPHQGEITFKDISASYGPASEPVLKGISFTIKPGEKVAICGRTGSGKSSLVAATLRMLEVESGSISIDGIDISSIPRQQVRSRLNTVPQDPFFLHGSVRQNVDPLDMADDERIKHVLRTLNLWNMFDNEEGLDGEVTQETLSHGQRQLFCLARSMIKAGKVVVMDEATSSVDAETDELMQRVLRHEFQGRTVITIAHKLHTVLDYDRVVLLDKGRIVETGNPQELLETPESAFRKLYEMLRSNAEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8Z3</accession>
    <name>A0A367L8Z3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Trafficking protein particle complex subunit 6B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8Z3"/>
    <dbReference type="STRING" id="1330021.A0A367L8Z3"/>
    <dbReference type="OrthoDB" id="941624at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14944">
        <property type="entry name" value="TRAPPC6A_Trs33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037992">
        <property type="entry name" value="TRAPPC6/Trs33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817:SF0">
        <property type="entry name" value="GEO08327P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="22532" checksum="15EEB5C56EA10398" modified="2018-11-07" version="1">MSLEPVMPPYNASDPSATFVSTSCFDFLLIEMVPLAKRLGGEGRTRHFPAFGALASRQGGGEDEDEEEERSEEARFRLEALGYRVGQGLVERFSKDRPRFNGALDIIKFLCKDIWSLVFGKNIDNLKTNHRGVYVLTDNVFRPFSRMSTEAGGQAVIRAQPFLWFPCGIVRGSLAALGMDTAVQAEIITLPAAVFQIKTLPAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAH2</accession>
    <name>A0A367LAH2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Enterotoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_7764</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAH2"/>
    <dbReference type="OrthoDB" id="4925998at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.210.10">
        <property type="entry name" value="Heat-Labile Enterotoxin, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017043313" description="Enterotoxin" evidence="2">
        <location>
            <begin position="24"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="734"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI11242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="774" mass="86927" checksum="093003F1E69236AE" modified="2018-11-07" version="1">MHWTKIITCAAPLWLSWLDPISAGLSGASGAIVRRQPGKFFVYRGDTRSPRTISADGGFRPHGHPNWVDNPRAFYIHRHYTGGPRGCGVSYIEDEPQDAVWETAYVSMAREESTAETYPGWIYEIVPTKNIFDDELSESEVLALGGVRWSQVRRFRWSYEVEKTWLPNPHYDAALWEDSPIRGISIHEENEALDEFVQLDETKYFDPVAQKAAMNFMRRERMVSHFGEFPPQFKYYPPHKDVPGDREIPPQFRGRREWESSSSESSSSSGSEDGGIWKMLGYDSKEEWDEAVRKDMTRTRTSSSGSEEVLDMWQSWGFDSKEEWEEMMRDSSKRFCKRDGLPCGELSLAKIGEADEDVLARLTEAVAAKDFEQMAVRFGVADLAKSRGGLEVSELRARLKGYQSLSSSSSIRIADGIKKAKNAGKGVLLIGALGLYIKQLVDVFSTETSALDRVAVVTSIVPVVGCGVQAGADGVKGDVDPIGKTLCVVGDVLLFTPLWPLGVLFQLTRMWWESVAKKLIEKISNPKTVYQSRLDGWNEFCGGVEKYVRSDTFADNIQRQYMAEMSAIIFKAAEAKGKLVTGTLSLLSKVNNATTTTGALSLQNNATTTTMSPQLQRRMMLRRAFFASRQIRDMVCREADKTKKRLRDQYKLQMTKWLQEQQTIFDDRFWDVLLREAVMVISVPLPVEVGVDAILHMTHRMEDLVKGYRSKSQPLPVWPRGVDDLNAIVDGHFDRFQPPSPCRKKGKKGKGGEPLAIAGGSSEHEAVGNQTATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAK5</accession>
    <name>A0A367LAK5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquinone biosynthesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_7470</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Membrane-associated protein that warps the membrane surface to access and bind aromatic isoprenes with high specificity, including ubiquinone (CoQ) isoprene intermediates and presents them directly to Coq7, therefore facilitating the Coq7-mediated hydroxylase step. Participates in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the COQ9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAK5"/>
    <dbReference type="STRING" id="1330021.A0A367LAK5"/>
    <dbReference type="OrthoDB" id="619536at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.10:FF:000004">
        <property type="entry name" value="Ubiquinone biosynthesis protein COQ9, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.10">
        <property type="entry name" value="Tetracycline Repressor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013718">
        <property type="entry name" value="COQ9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012762">
        <property type="entry name" value="Ubiq_biosynth_COQ9"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02396">
        <property type="entry name" value="diverge_rpsU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21427">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21427:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08511">
        <property type="entry name" value="COQ9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 8" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="domain" description="COQ9 C-terminal" evidence="9">
        <location>
            <begin position="158"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI11446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="256" mass="28494" checksum="C5376DFE466CE77F" modified="2018-11-07" version="1">MPPPQIMAPLNLTTTRRLASKLALRLRPRCFHSYEHATPTNPPFSAVEDAILAASYRHVPEHGFSQRTLRLGAHDAGYLDISPAALPEGVFGLIRYHLVTKRLALAERSRHLFTNHQQPLSVDTAVAELTWARLKENVAVISRWQEALAIMAQPTWLPSSLKELALLSDELWFLAGEKAVDSSWYTKRASLSIIYSTTELFMTNDKSTGFAETRQFLDRRLNDAAAAGKAISSVSQWVGFTGNASINVLRSKGLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAR5</accession>
    <name>A0A367LAR5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7275</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAR5"/>
    <dbReference type="OrthoDB" id="4927815at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="201" mass="20961" checksum="27473CF10C7B223E" modified="2018-11-07" version="1">MAAMPTTADDDEALPSSCLSASAQTRILIWRSEVASSFHPPHLPPSSASTSSGPSSTSTLGATTTTTTTTTTITSSLLLPRPSRSRRFWRRIVRRLSLSRPGSSVPAHDAGAATVAAFAAAETAAAGGPLAGGPPTEHDGVLRTAMYRSVPPLADPSDDEQPFDVPGSESDCSILKQKQERLGRAARLLQQQQNAVGPFAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBP1</accession>
    <name>A0A367LBP1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Succinate dehydrogenase assembly factor 3</fullName>
            <shortName evidence="8">SDH assembly factor 3</shortName>
            <shortName evidence="8">SDHAF3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_7376</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 8">Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the complex I LYR family. SDHAF3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBP1"/>
    <dbReference type="STRING" id="1330021.A0A367LBP1"/>
    <dbReference type="OrthoDB" id="278329at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034553">
        <property type="term" value="P:mitochondrial respiratory chain complex II assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006105">
        <property type="term" value="P:succinate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20270">
        <property type="entry name" value="Complex1_LYR_SDHAF3_LYRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008381">
        <property type="entry name" value="SDHAF3/Sdh7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13137">
        <property type="entry name" value="DC11 ACN9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13137:SF6">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE ASSEMBLY FACTOR 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13233">
        <property type="entry name" value="Complex1_LYR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI11821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="120" mass="13938" checksum="EFE81B97B680E83C" modified="2018-11-07" version="1">MLRPAFPRHFSSATKQQPALLPPIALYRRLLRAHRKHLPGPMRVLGDKYVKAEFRAHRNVDNQAHLIGFLAEWQLYAQKIEGDSWAGDKIDPGKMDKLSEEQTRQLFELMQAIQAHRQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LC49</accession>
    <name>A0A367LC49_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_0840</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI11995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LC49"/>
    <dbReference type="STRING" id="1330021.A0A367LC49"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="174"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI11995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="212" mass="22655" checksum="7A327838F948D385" modified="2018-11-07" version="1">MSGPINISSTTEWQSLLSKTSVVVADFYADWCGPCKMVAPHFERLATQHSRPNKMAFAKVNVDNQSAIARAQGVSAMPTFKIFHRGQCVDTIKGANTVALADAVTKALRLVDSGGSGDVFKTPGRTLGGGAAAARHSVFRPWDTAGFFKSLVAFFGLYLVSLFSFDARKAAEDSPFNMHGKPPSQRMPPSANAAARPSQKPSFKTLADLGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LC57</accession>
    <name>A0A367LC57_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">nicotinamidase</fullName>
            <ecNumber evidence="6">3.5.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Nicotinamide deamidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_0671</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; nicotinate biosynthesis; nicotinate from nicotinamide: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.19" evidence="6"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LC57"/>
    <dbReference type="STRING" id="1330021.A0A367LC57"/>
    <dbReference type="OrthoDB" id="3341310at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008936">
        <property type="term" value="F:nicotinamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019363">
        <property type="term" value="P:pyridine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052347">
        <property type="entry name" value="Isochorismatase_Nicotinamidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080:SF2">
        <property type="entry name" value="LD05707P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11080">
        <property type="entry name" value="PYRAZINAMIDASE/NICOTINAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="8">
        <location>
            <begin position="13"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI12018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="232" mass="25178" checksum="DA105D8C7A866A46" modified="2018-11-07" version="1">MTTSPSSPPFTPALIIVDFQQDFCPPDGALAVPDGTSIADPINSLLTLPFALRFATRDWHPPDHISFVTNHLPNKDSSLPPSEIRIHHPDDPDRSYVNSLWPPHCIQNTPGAQIVPILNQSSIDAVFDKGCDPRFEMYSAFYDPFRICDSGLAARLASAAVTHVYVVGLAADYCVAATAKHASELGFVTYIVNEATRPFYPHRWPDPDLAASGVSIVSIQGPEVAKVKAISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCI2</accession>
    <name>A0A367LCI2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_0718</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LCI2"/>
    <dbReference type="OrthoDB" id="10265969at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010628">
        <property type="term" value="P:positive regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09839">
        <property type="entry name" value="M1_like_TAF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000001">
        <property type="entry name" value="Paired amphipathic helix protein Sin3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000002">
        <property type="entry name" value="Paired amphipathic helix protein SIN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1160.11:FF:000003">
        <property type="entry name" value="Paired amphipathic helix SIN3-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.11">
        <property type="entry name" value="Paired amphipathic helix"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013194">
        <property type="entry name" value="HDAC_interact_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057345">
        <property type="entry name" value="Ig-like_TAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003822">
        <property type="entry name" value="PAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036600">
        <property type="entry name" value="PAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031693">
        <property type="entry name" value="Sin3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037813">
        <property type="entry name" value="TAF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057991">
        <property type="entry name" value="TPR_TAF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15137:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02671">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08295">
        <property type="entry name" value="Sin3_corepress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16879">
        <property type="entry name" value="Sin3a_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25316">
        <property type="entry name" value="TAF2_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25577">
        <property type="entry name" value="TPR_TAF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00761">
        <property type="entry name" value="HDAC_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47762">
        <property type="entry name" value="PAH2 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51477">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase interacting" evidence="12">
        <location>
            <begin position="2249"/>
            <end position="2350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1204"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1288"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1530"/>
            <end position="1583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1604"/>
            <end position="1647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1666"/>
            <end position="1761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1864"/>
            <end position="1909"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1921"/>
            <end position="1961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2056"/>
            <end position="2109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2533"/>
            <end position="2631"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1120"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1243"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1300"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1334"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1388"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1423"/>
            <end position="1460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1461"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1471"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1542"/>
            <end position="1568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1615"/>
            <end position="1625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1666"/>
            <end position="1681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1682"/>
            <end position="1692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1694"/>
            <end position="1704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1727"/>
            <end position="1745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1921"/>
            <end position="1933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="2540"/>
            <end position="2549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="2605"/>
            <end position="2614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI12127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="3010" mass="337415" checksum="D1F873CEF4E73E0B" modified="2018-11-07" version="1">MPLHDEVRQQPLLGETGSSSFSEDTSIQEYFILKQEVTLDVNFREKRIDGCTDIFMVTFNDKINDFVLDAASCEILTGGITITEIREAHGELVEGQKRTPKAEYLDPYAKLLYPDNWNWTSEHYNERRHRARSLFRNRRADVAAENREFQGCTPGYGSLKITLRDKGEQDRPKVIIRKSSANPETVPDRVHRHYKVTVPFINRSPRDGLHFVGVDPLDNRFSHLYSRHSIQPGTASCIFPCVDDHGARCDWRISIKFPRTLGDALQQALATQRDTSSSTAAVQDRSLGDGPDRFFRLAEEDKLREMTVVCSGFLMEETVDGQDDHKKIMVFEPEKKVSVQKLGFAVGPFEHIDLSSEFRAEEDEVKLGMSALKIHAYCLPGRGEWVRNTAAALTMAADFLTYTFAKYPFSNFKLCFLDDMIEDTVSLHSLAFVSNRLLFPEDVFDTETDVTRKIVTTLTYQWIGINMIPNTLNDLWLVFGIAHYMTDLFMKKICGNNEHRFRIKALSDRLVEMDIKRLSLWQLGPYLDLGGSQMDFMIVKAAVVVFILDKRLNKASGGHGLTRILQKLMTKAQIESGDRSIIIDTEKFRATCEKSSKFRLETFWNQWVYGSGCPHFDVKAKFNKKRLCVELTLNQFQHQVSKKTELDKEDFLRAINERRADIKIDDVQPLFTGPMTIRIHEADGTPYEHILEIREDATRFTKFEIPYNTKYKRLKRTRRLKERQTASDAAENAEEALLYSLGDVLQGPDDLRDWELIEWDPDTERKMDQESYEWIRVDADFEWACDMKRTLEPYMYVSQLQQDRDVVAQQDAMLYLGQGPLHPIASGFLVRTLVDRRYFHGIRSMAARALTRQANIKDIPMLGLRQLLRAFRDMFCYDQSNQPCPNDFSDKKQYRVRRAIIQAIAEVRDPNDRCPLEARRFILDQLMFNNNESNAYSDHFYIAFLLETLATSLIPSRKEEWYSRQNKASSQEDAEFLNDALEQIERVLRRDEWTNSYQNVWTIAGLEAKQRLMKAEVIPCQFADFAQYLLDGTLDLIRIKAFEALVDLGALLEVPFFSFFLYSLMTDRSPYVRSKLIRAMARGLAAIAFGEQVKPSDKSKATPDDTLLLVQDSAEEIEHRQEMFARRENLDAALRALRKEMEETHSKDYHYYSTAMRKAMDHPDLGRAEVESLLSLAEMMFEEATSFLVTFSYPKKWTVERQALKQTDRPRVQGGSSARSAQPRRLVMKFKSSFRTEPRRGASPPPPPPPPPPPPPPESKKPAVPQRTASIKINTKAATPQRPAATLVATGSEATPAPPSASQLSGGTTASGAASAKRARADKEDGGTPAPKRTKTEPRSETDKMAKKRRIVTLKTKDASRLKVILDQSPGLTASGRTALPSGPQKDSAAGSVNGASAVKPARKPLPTGERKPLPNGGGGPGSSQAAAPHTSKASANVNAAQASSPKAGSPASATPASSRPKIKIIRKPTLKSTQGSSLDPTQLSSPAAVQQLPENQHRLAIQVLSSPGDIHSVGTRGFHAWSERSLMNSQNLHGRGSGPPYDRELDHRAMQQHDDIRERDRDREQADRYQPAPHQSSTGSIPIHQPVASRIAGAIHSPGGLLAGSAPSAHLGAPPAPMPAPFPGPLQADQGRPVPHVGQQSAAAPQQHQVFAPMQPVSGAAQAAPSAAAAVYPQQQASQQPAPPQHQPPAAPHHQHQHQHQHQHQQQESQRAPKQTGAMVGGLTPGGHQIPGGITQGQQPILNPFSPPAHAPANPSSHMLPQHNGLMVAAQDALTYLDQVKVQFHEQPDVYNRFLDIMKDFKSQAIDTPGVINRVSELFAGNPNLIQGFNTFLPPGYRIECGGGNDPNTIRVTTPMGTTVQSIAGRGAQGDGQGAVAATQVPFPDRGGQWQQRPQHGVESPEATFNTPSQAGASLFAQAAAQSAPSDASGAQKSAAQALGNPGPAVTRGAHTPAPASVGGLDSINCNQVNMERRGPVEFNHAISYNRFQDKPEIYKQFLEILQTYQREQKPIQDVYAQVMTLFNSAPDLLEDFKQFLPESAGRAKAAQGRLEDAVALPGPSHTPQPANRDGHKMPPLGSFAPPASASKDKKRPRADKQAQNAESLVAETAAASRLQQSVVNGNKRAKLSHARGGADAAAPIESTLTPVMPEPYAPRPSATSTQEEVAFFERIKKFLSNKSSMNEFLKLCNLFSQGVMDKNTLFYKGALFIGANLDLMNFWKTFLGVESQDVVIDNRPAPPTEKLSLSNCRGYGPSYRLLPKRERLKVCSGRDELCNSVLNDQWASHPTWASEDSGFVAHRKNQFEEGLHRIEEERHDYDFNIEINLKCIQLLEPIAQQMLAMSPTERESFHMPAALAGQSTSIFKRICKKIYGERGIEVVNDLLSHPFVVVPVLLTRMKQKDEEWRFSQREWEKVWHAQTENMYLKSLDHMGILVKSNDKRNLTAKHLVDVIKTKHEEQRRERSLKGRSARHQLVWDFSDKDVVLDLLRLMMLYPLHSGQHSAQEKERLLEFFESFVSAFFDLNEEAVQDRLPKMPPDSAEEEVEESAPAELSNGRGKRNGKKADLLRGVLDPGRNGSKPRSQKEDSAASAGSKETTPDVGSANEEDMADAAEDAAATEVSNERWMPTVPKPVVVDGDNSLLDADGELKADGFFRRPWYNFFANQTIFVFFSIFQIVYSRLAELKASKSVVLHEIDRLTRPKPARDIGLADSVMNYFDKSDDVDRFWPKTLELIEDYITGEVEETRYQEVLRHYYLRGGWKLYTIQDQLKTLCRLALTCSSNDAKEKTPDLIHQYFVSREKEETSYQTEISARKFAEKCVKDGDLFVICWFPQKSEATARWLQRSDTTFYMDEMQLRERWQYYISSYIRVEPTEGIPRSRLQKVVLTRNLPSGDSDSDEDNVPKPVTYSENLTTSICLKSSKMVWAPGTSEFFIYDQTAKAEGRRVRRDDEREATRIVRQGKLLDKLVTNPPWAKDMGGDEMREIKDGFAAWVQDGVVPTEGGDGETED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCQ2</accession>
    <name>A0A367LCQ2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="8">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_0406</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ATP = O-phospho-L-seryl-[pyruvate dehydrogenase E1 alpha subunit] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23052"/>
            <dbReference type="Rhea" id="RHEA-COMP:13689"/>
            <dbReference type="Rhea" id="RHEA-COMP:13690"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="8"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCQ2"/>
    <dbReference type="STRING" id="1330021.A0A367LCQ2"/>
    <dbReference type="OrthoDB" id="241648at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16929">
        <property type="entry name" value="HATPase_PDK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000065">
        <property type="entry name" value="[Pyruvate dehydrogenase (Acetyl-transferring)] kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF3">
        <property type="entry name" value="[PYRUVATE DEHYDROGENASE (ACETYL-TRANSFERRING)] KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="10">
        <location>
            <begin position="305"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="117"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI12203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="439" mass="50113" checksum="02C900DD0DA9CF55" modified="2018-11-07" version="1">MSWRATDRLMDTIRHYAKFPATGVSLRQMVQFGDKPSTGTLFRASQFLAEELPIRLAHRVQELDHLPDGLNDMPSVQKVKDWYAQSFEVKDWYAQSFEEITQLPRPTISRDVRDRLTNSGRQKQLPQATPNPSIDEGDSSGWGGLNNGKSRSLSRRYFATVDDSGDWPPELQMYNQKFAQTLNKIKRRHDGVVTTMAQGILEYKRRRQRMQINGTVQSFLDRFYMSRIGIRMLIGQHIALTDQSHHRDPTYVGVICTKTNVRDLAQEAIENARFVCEDHYGLFEAPRIQLVCNPNLDFMYVPGHLSHMLFETLKNSLRAVVETHGMDKQDFPVTKVIVAEGKEDITVKISDEGGGIPRSAIPLVWTYMYTTVDRTPNLDPDFDKSDFKAPMAGFGYGLPISRLYARYFGGDLKLISMEGYGTDVYLHLNRLSSSSEPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCW5</accession>
    <name>A0A367LCW5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">2-oxoglutarate dehydrogenase, mitochondrial</fullName>
            <ecNumber evidence="5">1.2.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">2-oxoglutarate dehydrogenase complex component E1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">L249_0004</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 2-oxoglutarate + H(+) = N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:12188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:20092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83120"/>
            <dbReference type="EC" id="1.2.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the alpha-ketoglutarate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.2" evidence="5"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCW5"/>
    <dbReference type="STRING" id="1330021.A0A367LCW5"/>
    <dbReference type="OrthoDB" id="413077at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004591">
        <property type="term" value="F:oxoglutarate dehydrogenase (succinyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02016">
        <property type="entry name" value="TPP_E1_OGDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1150:FF:000002">
        <property type="entry name" value="2-oxoglutarate dehydrogenase E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11610:FF:000009">
        <property type="entry name" value="2-oxoglutarate dehydrogenase E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12470:FF:000003">
        <property type="entry name" value="2-oxoglutarate dehydrogenase E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000002">
        <property type="entry name" value="2-oxoglutarate dehydrogenase, E1 component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11610">
        <property type="entry name" value="Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1150">
        <property type="entry name" value="TPP helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032106">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011603">
        <property type="entry name" value="2oxoglutarate_DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042179">
        <property type="entry name" value="KGD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031717">
        <property type="entry name" value="ODO-1/KGD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00239">
        <property type="entry name" value="2oxo_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006914">
        <property type="entry name" value="PRK09404.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008907">
        <property type="entry name" value="PRK12270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152:SF4">
        <property type="entry name" value="2-OXOADIPATE DEHYDROGENASE COMPLEX COMPONENT E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23152">
        <property type="entry name" value="2-OXOGLUTARATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16078">
        <property type="entry name" value="2-oxogl_dehyd_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16870">
        <property type="entry name" value="OxoGdeHyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000157">
        <property type="entry name" value="Oxoglu_dh_E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="17">
        <location>
            <begin position="672"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00040267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00051911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RCI12269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1050" mass="118636" checksum="3685D5FFA53BA7CD" modified="2018-11-07" version="1">MLSKSLHTASRPLLRRARHPLSASRCSIPTVVAMFSSRGAVSSHVSIVLMAATRSYATSATHSPPDPRDNFLSGSTANYIDEMYMQWKHDPKSVHVSWQVYFKNMENGDMPISQAFQPPPNLVPNMTGGVPRLGGGLTLEDGSDVTNHLKVQLLVRAYQARGHHKANIDPLDIRNTATGFGNVKPKELTLEHYGFTEGDLDTEYTLGPGILPRFKKDSRVKMTLREIIAACEKIYAGSYGVEFIHIPDREKCDWLRERLEVPQPFKYSIDEKRRILDRLIWSSSFEAFLATKYPNDKRFGLEGCETLVPGMKALIDRSVDYGVKDIVIGMPHRGRLNVLSNVVRKPNESIFSEFAGTGGAEDEGSGDVKYHLGMNFERPTPSGKRVQLSLVANPSHLEAEDPVVLGKTRAIQHYNHDEKTHRTAMSVLLHGDAAFAAQGIVYECLGFHSLPAFSTGGTVHLVVNNQIGFTTDPRFARSTAYCTDIAKAIDAPVFHVNADDVEAVNFVCQLAADWRAEFQHDVVIDLICYRKHGHNETDQPSFTQPLMYKRIHSKKPQIDVYVNKLLQDGTFTKEDIEEHKQWVWGMLEESFNKSKDYQSTSKEWTTSAWNGFKSPKELAAEILPHHATKVDRKTLDHVGEVIGTVPEGFHIHRNLKRILSNRTKSVIEGHNIDFPTAEALAFGSLVTEGYHVRVSGQDVERGTFSQRHAVFHDQETEETYVPLQHISKDQGKFVIANSSLSEFGALGFEYGYSLSSPNALVMWEAQFGDFANNAQCIIDQFIASGEVKWMQRTGLVMSLPHGYDGQGPEHSSGRLERYLQLCNEDPRIFPSEEKLARQHQDCNMQIAYMTTPANLFHALRRQMQRQFRKPLIIFFSKALLRHPLARSDMEDFAGENAGFKWIIPDPEHQTGSIKPPEEVDRVILCTGQVWTSLYKYRADHNIDNVALTRIEQLNPFPWKQLKDNLDMYPNAKTIVWAQEEPLNAGAWSFTQPRIETLLNQTKYHDRKHVMYAGRNPSASVATGMKQVHSKEEHELLEMAFTVKQDKLKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LD00</accession>
    <name>A0A367LD00_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">mitochondrial processing peptidase</fullName>
            <ecNumber evidence="5">3.4.24.64</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Beta-MPP</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">L249_0272</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalytic subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins. Preferentially, cleaves after an arginine at position P2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2.</text>
            <dbReference type="EC" id="3.4.24.64"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.64" evidence="5"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LD00"/>
    <dbReference type="STRING" id="1330021.A0A367LD00"/>
    <dbReference type="OrthoDB" id="10251424at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000002">
        <property type="entry name" value="Mitochondrial-processing peptidase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000001">
        <property type="entry name" value="Mitochondrial-processing peptidase subunit beta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF149">
        <property type="entry name" value="GH01077P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="16">
        <location>
            <begin position="47"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="17">
        <location>
            <begin position="199"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RCI12296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="471" mass="52546" checksum="D7D891CE09FFDEA6" modified="2018-11-07" version="1">MASRRLALNLSRGLRLRSGLSALRRGLATPAAASTTQTTTLSNGLTVATEYSPWAQTSTVGMWIDAGSRAETDETNGTAHFLEHLAFKGTKKRTQQQLELEIENMGGHLNAYTSRESTVYFAKAFNSDVPKCVDILSDILQHSKLEESAIERERDVILREYEEVEKQTEEVVFDHLHATAFQHQPLGRTILGPRQNIRDITRTELVNYIKTNYTADRMVLVGAGGVPHEKLVELADKYFARLPTRGPENHAYLLSKQKADFIGSDVRIRDDTMPTANIALAVEGVSWNSDDYFTALVAQAIVGNYDKAMGNAPHQGSKLSGFVSKHDLANSFMSFSTCYSDTGLWGIYLVTDKLTRVDDLIHFAIREWMRLCTNVSEAEVERAKAQLKSSLLLSLDGTTALAEDVGRQIITTGRRMSPGEIERKVDAITETDVMDFANRKLWDRDIAVSAVGSIEGLFDYQRLRNTMKPKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDN0</accession>
    <name>A0A367LDN0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_1180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDN0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI12529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="144" mass="15949" checksum="9C3A8E89FFF827CD" modified="2018-11-07" version="1">MLTQYYIAPVIVIKYLDDCFVVYSGNQAIVVTFLPLIYVLQDCSSLNTLRKETAKSNPPANDTINTIPAIAINYLVSNASSLVEGTTIDINPGSIPLYNILHLVTTPPTNIAKELYGFEGILNPMPRYKSNLKPLNFVKINDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDS3</accession>
    <name>A0A367LDS3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EKC/KEOPS complex subunit GON7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L249_0333</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. GON7 likely plays a supporting role to the catalytic subunit KAE1 in the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the GON7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDS3"/>
    <dbReference type="OrthoDB" id="2288868at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014849">
        <property type="entry name" value="EKC/KEOPS_Gon7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08738">
        <property type="entry name" value="Gon7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0779">Telomere</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="61"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCI12566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="97" mass="10888" checksum="321FEEA339F40945" modified="2018-11-07" version="1">MADSRDLTLKAVYKSATNESFSVVRHITAPLSDAVAEKVRCLETLRNAVDETQALVNKELTTRMEEDKAREAHSSTKLGVDEDKEEDNYGEDVQDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDW3</accession>
    <name>A0A367LDW3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GP-PDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_1029</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDW3"/>
    <dbReference type="STRING" id="1330021.A0A367LDW3"/>
    <dbReference type="OrthoDB" id="1058301at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43805">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43805:SF1">
        <property type="entry name" value="GP-PDE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="3">
        <location>
            <begin position="420"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="377"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="409"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI12601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="710" mass="80403" checksum="84A3AA44D641EA5A" modified="2018-11-07" version="1">MVSSEPDHAPPPCRISENHIDFFFRLWAPLFPIVDEELFRSRHRVLLVDAAYVKEYHMIQFHLVFSIAELSSRMPNCSQVTECKRQWQYPLETKLVANSMEHLECLVLAILFCILAGDNDRLQCYKSMALSATHLLGLYRPKKDNVPKNVMSTLYILDCFTTASLGLPRLFGHAMIHAHIKDMEQISCHHALLGASICLSNVLETMYPLATAGRASQETMMTFTKEIEAWYLKLPSRLRLRSLNEMSPNKDKQIAADLLLAYYYIRWLIYLPGFQSSGWPHNPLLQAATTMADIMLRKTTWGLSFCINKPRMMTVLASMLLIEAARVHQEKSGSDMAMNLRRNETGMKMLGDSSSRGPKQEPMADETRPLLLLDKEGLRDDQPSPSSPSPSSPSSPSPPPPPWQQPKRNNSTNATATSTPQTIAHRGDKAHERENTLPAFHAAVRSRAHAIETDARLSRDGVAVLAHDDGLQRCFGRRGRVADFDAELLGSWGVVTLVDLLAWLVDEDEQQGQSDEDRLWKRGMWILLDIKMDDDPALLLAAIARALKTATTTTIPWEKRIILGCWNASTILAARRLLPNHSLAHIGTSSSYARHFLRSMPSLALNMAYTAIPFLPSSVATARPLFAWTVNSEATMRWAIRHGAIDGVITDDPAAFRALCRRHELELARRPLPPPLRRSLSGAWDWCRVLFWHKIVFLYRRFWLKKLDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LE19</accession>
    <name>A0A367LE19_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Complex 1 LYR protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_0872</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I LYR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LE19"/>
    <dbReference type="STRING" id="1330021.A0A367LE19"/>
    <dbReference type="OrthoDB" id="275715at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990221">
        <property type="term" value="C:L-cysteine desulfurase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20264">
        <property type="entry name" value="Complex1_LYR_LYRM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008011">
        <property type="entry name" value="Complex1_LYR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045297">
        <property type="entry name" value="Complex1_LYR_LYRM4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051522">
        <property type="entry name" value="ISC_assembly_LYR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13166:SF7">
        <property type="entry name" value="LYR MOTIF-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13166">
        <property type="entry name" value="PROTEIN C6ORF149"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05347">
        <property type="entry name" value="Complex1_LYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Complex 1 LYR protein" evidence="2">
        <location>
            <begin position="39"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI12669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="131" mass="14979" checksum="6F88A3052A1E9A89" modified="2018-11-07" version="1">MSASGSLKGTMSQKVLSLVNASLGDLVRSSLWRAGTTQYRQLLRQSKQFSAYNFREYAKRRTRDAFHENRGVQDKRLVEELVQKGLRELQVMKRQTVISQFYQLNRLVVEGGISGREGGERGDKVRQKDQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LE33</accession>
    <name>A0A367LE33_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LE33"/>
    <dbReference type="STRING" id="1330021.A0A367LE33"/>
    <dbReference type="OrthoDB" id="21292at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="239" mass="27132" checksum="91E9F14832D6ECFD" modified="2018-11-07" version="1">MRSEFDADADMLSLAPSPVFSTLRDHRPMVSSPLTSSPIRVSTPPNAHNSSPPTGRAMSPLSPSDRNSLPQRQAQSSPIRSPPPKFKYASRPKRPNPLLRTPEASREIRRRNFFQRIRDTADDMAWQRRDIENQFLRNNWLANIGCLSHDAPCLTEADLADAMALYPDQPQPPEDEEDEMTVERCREQEEMEAMAASFEDQHITSTSDDEYDEIFAELALQDTPLQNHPPDSSDHMDMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LET6</accession>
    <name>A0A367LET6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_0935</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PhyH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LET6"/>
    <dbReference type="STRING" id="1330021.A0A367LET6"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF15">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="209"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI12938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="34950" checksum="D0C4F6FF2E5A1E53" modified="2018-11-07" version="1">MTMASEQGLSPSQVASFHRDGYLILRNALSTPQVSSLLTETRRLLSSLNLSDHPMTRFTTGTSAAGHVGDDYFLTSGDSIRFFLEEDAFDKDGNMLVDEAAMAVNKMGHGLHRRSEPFAALLQSSPPAVARALGFRDPRVLQSMVICKHPRLGGAVAPHQDSSFLYTSPPSALGFWYALEDAGLDNGCLWFLPGSHRWAPVKSRLVRKSGDGGTEMVDNQGPRFPGPGASHPDSDPDPDPDPDPVSNAVYVPAEVRAGDLVLIHGNLLHKSEKNTSDRGRIIYTFHVIEADGTTYDDRNWLQPGPDGFTRLYHPDQSAAQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEX4</accession>
    <name>A0A367LEX4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Delta(24)-sterol reductase</fullName>
            <ecNumber evidence="2">1.3.1.72</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_0489</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.72" evidence="2"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEX4"/>
    <dbReference type="STRING" id="1330021.A0A367LEX4"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000246">
        <property type="term" value="F:Delta24(24-1) sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050614">
        <property type="term" value="F:Delta24-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008202">
        <property type="term" value="P:steroid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040165">
        <property type="entry name" value="Diminuto-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801">
        <property type="entry name" value="24-DEHYDROCHOLESTEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10801:SF2">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="114"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI12967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="596" mass="69029" checksum="EEA2B19C99D4BEFA" modified="2018-11-07" version="1">MAVKKSSAVADYTKHAGSPSTRAVRWLHHLITSALVLVANFTLIPAIELHGLLFSLLADVALWPTLQLLQRTPVYPWLVDFCVRHRGWFLAFTMVPLSFAHEQYSRLRNWYHGAFLATPHLHDARVHQVQQQVWAWNQAGRKRPMVTARAPWLSVSVRVESYKDTCDKIRVNLSNILEVDTERMTVRCEPLVNMGQMTRHLIPMGYSLAVMIEMDDLTVGGLFMGVGVEVSSHIYGFLSETVHACEVVLGDGTLVRCSREENTDLFHALPWSHGTLGFLVAVELSIVRIKPYVHMKYIPCYSQDELLDKLTVLTHSSTPPPLIETTVYSKDTAVIFTGDFSDGPPADQAHRINDVSRWWKPWFYKHVESFLDRGPGEDWIPLRPYFHRHTRSIFWELREVIPISTHWWYRYVFGWMGPPKIAFIKLSSAPAIREASVFKHVVQDVVVPLRDLKDTIDLFHGAFEVYPLLLYPVRIYKQPDGLQGVLREPSHLRTEPTTGRSYEMYIDLGAYGVPPKLKRKEPWDAIKEVRRMEKFTRRRRGYQLLYADCFMTRAEFEEMFDHSLYRQCRRKYKAIGAFPEIYDKIKSKYCPASMTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEX7</accession>
    <name>A0A367LEX7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Flap endonuclease 1</fullName>
            <shortName evidence="15">FEN-1</shortName>
            <ecNumber evidence="15">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Flap structure-specific endonuclease 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">L249_0131</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Nucleus</location>
            <location evidence="15">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Nucleus</location>
            <location evidence="15">Nucleoplasm</location>
        </subcellularLocation>
        <text evidence="15">Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14 15">Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="15"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEX7"/>
    <dbReference type="STRING" id="1330021.A0A367LEX7"/>
    <dbReference type="OrthoDB" id="1937206at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09907">
        <property type="entry name" value="H3TH_FEN1-Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09867">
        <property type="entry name" value="PIN_FEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000009">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000003">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00614">
        <property type="entry name" value="Fen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023426">
        <property type="entry name" value="Flap_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF9">
        <property type="entry name" value="FLAP ENDONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 15" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6 15" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 15" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 15" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 15" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="18">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="17">
        <location>
            <begin position="146"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="360"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="360"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="387"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RCI12978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="396" mass="44870" checksum="3F88D1992AF9A1CD" modified="2018-11-07" version="1">MGIKQLFQIIKDEAPDAVKEGEIKNHFGRKVAIDASMSIYSFLIAVRSDGQQLMNESGETTSHLMGMFYRTLRMVDNGIKPLYVFDGAPPKLKSGELAKRFQRKKEANEGLEEAKETGTAEEVEKFSRRTVRVTREHNAECQRLLKLMGIPFIVAPTEAEAQCAVLARAGKVYAAASEDMDTLCFDTPILLRHLTFSEQRKEPIQEIRLDKVLEGLKMERKQFVDLCILLGCDYLDPVPKIGPTTALKLIREHGSLEKVVEAIEKDSKKKYTLPADWPFEDARQLFFEPDVRKADDPLCDFKWEKPDTEGLVEFLVKEKGFSDERVRGGAARLEKNVRSSQQARLEGFFKVVPKSEEEKSALKRKVEEKNEEKKKKLKMEKKEKAAAKAKARGGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LF74</accession>
    <name>A0A367LF74_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SMP-30/Gluconolactonase/LRE-like region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1117</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LF74"/>
    <dbReference type="STRING" id="1330021.A0A367LF74"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052988">
        <property type="entry name" value="Oryzine_lactonohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G08990)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064:SF2">
        <property type="entry name" value="SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="1">
        <location>
            <begin position="142"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="360" mass="40076" checksum="0E5915FE088F7B4C" modified="2018-11-07" version="1">MRSVNMSALLSAATDAQYLAKLPDSGISLLSYHSDFLQLLGPDATARQVWDLPWEAFHEAGVYNKKDNSLYISSNYNGMDDNINITVVSLDTDEYNFYSTQFPHLAMANGGSSYYPPGSSRNHTPPMHVYCDEGDFEHYSQLIAVDPNTNQSYPLLTNFLGKNFSSINDVRQHPVTGDLWFTDADYGYFQHFRPPPKIPKQVYRFEPSTGVIQVVADGFIQPNGIEFSPDLGTVYISDTGSQQFDVVPGQPSTIYAFDLVKNKRLANRRVFAYANVGFPDGVHCDTQGNVWAAAGDGVHIWNPEGVPLGKIYIGETSNNFAFAPGKVFVFSNHRLWVVENVTALGREVCTDFGRDLECCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFE6</accession>
    <name>A0A367LFE6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0425</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFE6"/>
    <dbReference type="STRING" id="1330021.A0A367LFE6"/>
    <dbReference type="OrthoDB" id="4448936at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="208" mass="24299" checksum="27426DE677C93596" modified="2018-11-07" version="1">MSQQNSKSEEEDDDDTLLEGRRRSEENDQDQSKCDSSSPLLLFRTRFSDLSASLQRRTSRSDDDDDDDDHEDDDEPKRCATMAKLRRHNSKILVEVAKLNLELSAVVTNLRARREESDHINQLLIERAERAAQRIIFLQSRIATLEQELSENDDDLQHLHIRIKALEIQLKPHPDEDLQRCLSVIRHDYQALRRKRASRPVVDYSPPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFN7</accession>
    <name>A0A367LFN7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFN7"/>
    <dbReference type="STRING" id="1330021.A0A367LFN7"/>
    <dbReference type="OrthoDB" id="14339at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37332:SF1">
        <property type="entry name" value="ELMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37332">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="434" mass="46947" checksum="6F2179967EEA27D9" modified="2018-11-07" version="1">MQRSTTPTTTPSSFLNLSIFSPPPIASVQRPVTRDGTEAPSPRHQHHHHYHLPHSLARKASLSAFSSRRRRSSLSSPGSPSATFFTDAAAPPALPDYALSAAAKVQQGRSPVRSSDSGSSIKAPGRMFANAMPASGPVAVNGSVHGPFASGSSAPTVTAAPTSSSSIWQPSEASVIHQQIAELATKRISTLDYLRKAHEGRVYWFNTYLFDRPDLTRMSYFDPRKLARRATNFLLLGLSVPTINDLYSSSAIEFLRCLNALLSEFDSFQQLHGDSSATLTRARLPNMFRRQGGKTRRSSSATDFADESQALPALPGGAAAGTPSVMTFAAAESDLLPGEEYTYLLTPSLPFEPDFFETFATLCDVLIDCYRRFLALVPTPRECSAPVAELFSKVDSKLRKIIVQGPVKELEDQSRSQVRAEVASVGKVVLGGLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFR7</accession>
    <name>A0A367LFR7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFR7"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="68" mass="7854" checksum="EAF7772569171046" modified="2018-11-07" version="1" fragment="single">RVQLSNSGYLYTFNLFFTAFLFTFRPTNYLIRTQTDLLFPTKFPLSATIGNVEKYSFAKLSGSGNYTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFW6</accession>
    <name>A0A367LFW6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0631</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFW6"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="77" mass="8678" checksum="F8C39AB66B602550" modified="2018-11-07" version="1">MTAAVKTPSCKACWSLEMDGRINLRGFYMFISPDGTPYQRNSEDLHENKPRSAVSQTMKSKSQSLTHYSTISWDDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFZ1</accession>
    <name>A0A367LFZ1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFZ1"/>
    <dbReference type="STRING" id="1330021.A0A367LFZ1"/>
    <dbReference type="OrthoDB" id="3061561at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="426" mass="46919" checksum="098D8D9E693B1E40" modified="2018-11-07" version="1">MFSPNCTLPSASSGFVTAPSIRGTMNIVYTCAGILIICTWNVLHLNIPTQSTPRHGIQRFMRSALRLLPKIANLVAPELILSKAWSEYLSVRSMQHDFEHYAKIDDVEWTHKHTHLANMGGFTIFFQGGVWSLDAKQLLIARHLGIIDRLPSLSVDAIDDRSKQDFLIKFLSAVQLIQFGAEILTRLLNQRSISQLEVVTLTLALPTLPAYYLWLGKPKDIYTTIDMGVPAAKRPSVGNIRRLAKNGPRVLLPRQLAGPLTPKSSGPTFSLPNYIIHCGNSAGSVEGAEDDGRDGHEIADGDIAVDTERLTVFSSVATTVTGAVHFLAWNSALGNDSLRLLWRVSAVATMVSMPAMLIVFYTATRFSRLNKLILSGQGRSKCIAGFFWAILITGRLLIGVVAFTSMWYLPPDAFTASWTVYVPHLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFZ8</accession>
    <name>A0A367LFZ8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_0791</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFZ8"/>
    <dbReference type="STRING" id="1330021.A0A367LFZ8"/>
    <dbReference type="OrthoDB" id="153074at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000281">
        <property type="entry name" value="Uncharacterized oxidoreductase YIR035C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF8">
        <property type="entry name" value="BENZIL REDUCTASE ((S)-BENZOIN FORMING) IRC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="4"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI13353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="250" mass="26782" checksum="BBAC8F8B67CF772B" modified="2018-11-07" version="1">MASKVFIVTGASKGIGLAVARHLLSQSHKVILAARSEEPLRALRQSHPTLVDYVAGDITNPHMAGELADRAVQSFGGIDGIVISHGVLDPRRIDGSTIDEWKHIYDVNVFSCLAMAKAGITELRKSKGCVVWVSSGAAAKPYKAWAAYGSSKAAVNAISAHLAVEEPDVTSIAIAPGRVDTGMQAVVREAGKDGMDKAQYDSFVEAFQQGKLLKPEQPGHVIARLAARPRKELSGNFLNWNAPELAEYQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGG5</accession>
    <name>A0A367LGG5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Oxaloacetate acetylhydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_0792</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the isocitrate lyase/PEP mutase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGG5"/>
    <dbReference type="STRING" id="1330021.A0A367LGG5"/>
    <dbReference type="OrthoDB" id="1923844at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000009">
        <property type="entry name" value="2-methylisocitrate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905:SF2">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13714">
        <property type="entry name" value="PEP_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00061405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI13352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="37102" checksum="400AA1D1E20EDF6C" modified="2018-11-07" version="1">MAPAAIEDAVSRHRSHERIPGDDSPSLQVDSFLSLGHLAATMPEPSSGATKLRRMLLETNELIVCPGVYDGLSARTAIELGFDALYMTGAGTTASRLGQPDLSIAQLHEMRENADMIANLDPFGPPLIADMDTGYGGPIMAARTVEQYIRSGVAGAHLEDQVLTKRCGHLSGKKVVPREEYYMRIRAAHAARVRMRSDFVLIARTDALQTLGYDECIERLRTARDLGADVGLLEGFQSKEQAARAVRDLAPWPLLLNSVENGASPTITVDEARQMGFRIIIFSFACLAPAYRAIRETLTLLKAEGVVGTPKELTPKRLFEVCGLKHAVSVDVEAGSLSFAGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGH0</accession>
    <name>A0A367LGH0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">2-oxoglutarate reductase</fullName>
            <ecNumber evidence="4">1.1.1.399</ecNumber>
            <ecNumber evidence="5">1.1.1.95</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">L249_5508</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 20">
            <text>(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="EC" id="1.1.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(R)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.399"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.399" evidence="4"/>
    <dbReference type="EC" id="1.1.1.95" evidence="5"/>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGH0"/>
    <dbReference type="STRING" id="1330021.A0A367LGH0"/>
    <dbReference type="OrthoDB" id="1621027at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061759">
        <property type="term" value="F:2-oxoglutarate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12176">
        <property type="entry name" value="PGDH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000036">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000041">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050857">
        <property type="entry name" value="D-2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008759">
        <property type="entry name" value="PRK11790.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00670">
        <property type="entry name" value="D_2_HYDROXYACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="16">
        <location>
            <begin position="54"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="17">
        <location>
            <begin position="158"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RCI13515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="461" mass="50467" checksum="01A90F0E5BE9070A" modified="2018-11-07" version="1">MTQARDIQRPQQLSAQTSPTATGLQSPASSWGAVLAQQATPKLLKPFNTQDINILLLENVNQTGQDILKDQGYQVEALKTSLPEDQLIEKIRDVHVIGIRSKTKLTERVLHEARNLLVVGCFCIGTNQVDLEYAARHGIAVFNSPFANSRSVAELVVAEIITLARQLGDRSSEMHRGNWNKVSSKCWEIRGKTLGIVGYGHIGSQLSVLAEALGMNVIYYDVVTLMALGTSRQVPDLESLLAESDFVTLHVPDLPETRGMISTKQLDSMKNGSYLINASRGSVVDIPALINAMRSGKVAGAGLDVYPHEPAANGDYFNKSLDDWAEDLRTLNNIILTPHIGGSTEEAQRAIGIEVASALVRYINQGITVGSVNLPEAQLRSLTLEEPEHARIIYIHRNVPGVLRKVNEILGNHNVDKQISDSRGDVAYLMADISRVKFGDIKEITDSLNGLSSCIMTRVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LH47</accession>
    <name>A0A367LH47_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_8089</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LH47"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI13763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="218" mass="24534" checksum="3A1D6418CA0D6D77" modified="2018-11-07" version="1" fragment="single">MARERERERVRVRVRVSEVKVDKQSGLYHGNGGEDDDDDDDDEGEDDEDSSGGPTAAQGLSRRMRGGKGEEEDEDGDEDEGEEEEEEEEEEEEEEAIQTDRQTDRQTVLGSEEEAEPLTGQCQLARRRHCVCISMTIVHRCILLTFNFKASTTHLPSSYMYTYGERAGQGKRNSRLISSRLTTTLLGLNPIIVIVIIIITTIIITIIILRYQPSSALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHI4</accession>
    <name>A0A367LHI4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHI4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="6"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="38" mass="4293" checksum="4F8BBAC459C8A6CB" modified="2018-11-07" version="1">MFIFIVARSRQHDDDDDDDDFGAGERKGSDDDDDDDDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-05-03" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIF2</accession>
    <name>A0A367LIF2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIF2"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="195" mass="21804" checksum="528D0CAB85848668" modified="2018-11-07" version="1">MAPSAAPLDRAPGNTVGRPIDSLQRSLQRSARCTYSGYSTRLISAQGSRYSDRRAVPIAVIALDQSSQRDRHSDRRAVLIAVIAPDLDGRTKVRSTFRSTFVIEKFVYKGRRFSHLLPVHYQLQLHYFFNTITSPAFNSSLILTKPPSRYEPGFSHLIRDTNKLSTNFLPPSSSSTAPQNTLFDSTFPTLGLEQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIH8</accession>
    <name>A0A367LIH8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4219 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIH8"/>
    <dbReference type="OrthoDB" id="3599317at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="24629" checksum="460C79E9C273E3ED" modified="2018-11-07" version="1" fragment="single">PIDSLQRSSQRSARCTYSGHSTRLISAQGSRHSDRRAVPIAVIALDQSQIVRLIHDVEVFLQTTYLPRRRFSHLLPVHHQLQLHHFFNTITSPAFNSSSILTKPPSRDSSSSSLLQIMPNTEKITFAKLSGGDNYTYWALRMDSLLIREKLQGALGSETHNKSEEALALIRLQLEDGPLTQIIHIKTALEAWNRLKELYNPVSFTSNFLLTKELLEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJ19</accession>
    <name>A0A367LJ19_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJ19"/>
    <dbReference type="OrthoDB" id="4927519at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="147" mass="17023" checksum="281D4A7AC8886495" modified="2018-11-07" version="1">MSNYIAGGGCCPSCCQAPDLGDHDYCPPCTCTKPTTSSQRNRRFSLSTAEAAAFIPDRHLTDEQFHRNEHRRQLHYQTHLFQQQQAREAAAERERKMAEQKELEKQLAKDKKAQDKEDRKKQKKQKQNQNDDEKKKKDRDNASCTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LK44</accession>
    <name>A0A367LK44_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 subunit A</fullName>
            <shortName evidence="7">eIF3a</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 110 kDa subunit homolog</fullName>
            <shortName evidence="7">eIF3 p110</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Translation initiation factor eIF3, p110 subunit homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TIF32</name>
        <name evidence="10" type="ORF">L249_6471</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the eIF-3 subunit A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LK44"/>
    <dbReference type="STRING" id="1330021.A0A367LK44"/>
    <dbReference type="OrthoDB" id="18884at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043614">
        <property type="term" value="C:multi-eIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.860:FF:000003">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.10:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.860">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.10">
        <property type="entry name" value="UVR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03000">
        <property type="entry name" value="eIF3a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027512">
        <property type="entry name" value="EIF3A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054711">
        <property type="entry name" value="eIF3a_PCI_TPR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14005:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14005">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3, THETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22591">
        <property type="entry name" value="eIF3a_PCI_TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PCI" evidence="9">
        <location>
            <begin position="444"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="717"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="919"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="919"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1033"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1087"/>
            <end position="1097"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI14798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1176" mass="132464" checksum="285A93E3A1751BC9" modified="2018-11-07" version="1">MKKILSPRGLINTRSNRDPRKSVEFSICASDQATRNLHIRTQNTSITVSNSPYHSACPADADLILSEHNSKFLLTSPPVSRLSKDEPQQVPHLAGSLTLKEWLPSMPPPPHQKPENVLKRAHELIGVNQAPAALTLLHEHITSKRSRNAPIASLEPVMLLLVELSVEQKKGKLAKDALYQYKNISQNTNIATIELVLKKFIELAVEKVTAAQQKADQVQSSIDASAATSSIDDLEASETPESILLATVSGEQSRDRTDRAIVTPWLKFLWEAYRTVLDILRNNARLELLYQSTAMQAFDFCLKYTRKTEFRRLCELLRNHVQTAAKYSSQMHAINLSDPDTLQRHLETRFQQLNVAVELELWQEAFRSVEDIHTLLNLSKRPPKNVMMANYYEKLTRIFLVGENYLFHAAAWSRYNSLLRQSAALVAGGQGKKSDNPPASDADLQKAASFVLLSALAIPVISTTRSRGAMVDFDEAKKNKNSRLTHLLGMTQAPTRAKLFRDALSKSLLQRARPEIRDLYDILEVDFHPLSICQKISPILTKIGADSEMERYILPLQQVILTRLFQQLSQVYETIDVEFVQGLAQFPEPYQVTRSTIEKFIMNGNKKGDLAIRMDHATGVLSFDNDVFSSARAGQSGSAESETGTVQRLQSTPSEIVRSQLTRLARALYTTCHYIDPSFNKERLTARNAALARAKAGAEEEHLEVLARKEIIQKRKEEASEMQAKREKENARQKRLREQALQEAEDKRLAAEQKEREAKRLKAERDRVRKEELKKQIADLKMSDKALDIDLEDLDNLDGNRLRAMKLAQLEREKNDVNERLRVTGKRIDHLERAFRKEEGRKLSQDYAKQNELDRAVHEKLKAKTLKDAEEKHKESVELKHRLSRLVPLYEGFRRSLHERRRDEFEKRRKDAERELEKQIAARKKEVRDRKLREKREREEKERELREAEERAAREKEEQRLRDEARRAEMAKLKEQRERERQETLEKAALQQRREEEALARRKAEKERPSLGGKADGPDGRRPPVTAGGSSWRAEGGAPARAAAPTERGDSKEQPSGEGPRLQLKGSKAGGGWREREAKKLAAAAAAGGGGGGGDGAENGPSGREAGGRGGGMERDDGGRTASAATDARPSGGEKWAGGRGGGMERDDGGRTASAATDARPSGGEKWVPKWKKNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKF3</accession>
    <name>A0A367LKF3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cell wall protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_6742</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKF3"/>
    <dbReference type="OrthoDB" id="10651724at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016801298" description="Cell wall protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI14904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="182" mass="19267" checksum="8A1B02181870D17D" modified="2018-11-07" version="1">MHFTTLAAIQLAWTAAVVDAAPRHFDTETEMEPRQLGGDFDALGGAVAVPFKLVGSILRRDDGGGDEKRYLQPYSEGKKEEDCDDDDDDDVTVMVTATATARHSVVVPAPSAPSTAGYDVARSTATKKKAAGPPYPTTASEKPAAQEDYKVASSTPAGYEVRAVQPTRTASSATTTCTPHDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKJ5</accession>
    <name>A0A367LKJ5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKJ5"/>
    <dbReference type="STRING" id="1330021.A0A367LKJ5"/>
    <dbReference type="OrthoDB" id="3559694at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024316">
        <property type="entry name" value="APQ12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12716">
        <property type="entry name" value="Apq12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="178" mass="19394" checksum="06EF60F2B5BA077B" modified="2018-11-07" version="1">MEAYIFGLVADLLPPEMAAAARHYLLRPDSPLQSCKRHLAATARAGIVALTDVAAGALAASESQGGGGGGVTGVVTTLALLAVSALLLRWLGRLVMWWTRFTLRLAWWASVVALCACVWQRGPVATLQSVLVGVGALMRYLAILRDVWLAEYNRYEVQERQQQQQRQFTASRARGSAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKY9</accession>
    <name>A0A367LKY9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKY9"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="107" mass="11270" checksum="93FD326D7E8FC66D" modified="2018-11-07" version="1" fragment="single">FSSDAAAPVRLVGETADGPAFYDASLNLPICHMLFYPQLSLPITEKRRNRSQLAGAAKGGSSFHSLTLPALNPTDGAEGEGGKGRRVRHVPMKISFSTGSVDQGRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LL72</accession>
    <name>A0A367LL72_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_6423</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LL72"/>
    <dbReference type="STRING" id="1330021.A0A367LL72"/>
    <dbReference type="OrthoDB" id="262547at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF210">
        <property type="entry name" value="ZINC-REGULATED TRANSPORTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="15"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="470"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="504"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="538"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="131"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="268"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="151"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="187"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="275"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="332"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="345"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI15159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="560" mass="61623" checksum="4C028B268264C724" modified="2018-11-07" version="1">MELVASRLDNDTRGWIMAIVSGVACVLGAAIICVDVIVRLLPGKRRFRIQDSNVFLASSLSLSFGVMLFSSLFSMLPESKEYLTHDEGWNDQRAGFVMMACFCAGFLGIQAVSRLLHQYMPSHVVDCNHSHAEADAQPDHRVPRRRSSVGRARLSRPSSARPASKDGPRPSEATPLLAKTDGETPQFVVTDQSVGSASRGRTTTTTTTTATTATTTTAGSALSRRPSMYHVQKRVMSFVKDTKCGCDEEGLCYGYTDPCGQECFKHLSTKRSSRHPTTLRTTTGLFPDHHDGVEPVSPLFRTSRAASREPLDGTGQRDGDEHPLDQHLNHPNAHHHHLHHHHHDDEDDNDNSTDNDYDHVHDHDHDHDHAHAHDSDIRRVSLDQEDGDNDTEAQHHHHVPTNAFLSIGLQTSIAIALHKFPEGFITYATNHANPALGFNVFMALFVHNITEGFALALPLYMALGSRWRAMLWSALLGGLSQPMGAAIAALWFRLASRTHLTPNAVAYACLFAATAGIMVSVALQLFVESLSLNHDRNLCIFFGFLGMVLMGFSNALFAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLJ4</accession>
    <name>A0A367LLJ4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLJ4"/>
    <dbReference type="OrthoDB" id="4931706at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="170" mass="18344" checksum="AED60F653B090108" modified="2018-11-07" version="1">MPSSDNAFPPRSKTFSYSSANKTRINSNDSLPPDSPTASGLPDPAPPFADSSSTPREVLRCVTRGDRAFPPALRLKRTATSTPAAASAFATASRSPTPDAPPLTFRALINCAAASSNLSTTPTLLGTLAGTFIRRFLRNCDVCGRSKVWRSYRATLLRSLPTLDQFYRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLJ6</accession>
    <name>A0A367LLJ6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Exportin-T</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Exportin(tRNA)</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">tRNA exportin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_6606</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <text evidence="11">Shuttles between the nucleus and the cytoplasm.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the exportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLJ6"/>
    <dbReference type="STRING" id="1330021.A0A367LLJ6"/>
    <dbReference type="OrthoDB" id="26399at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071528">
        <property type="term" value="P:tRNA re-export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000355">
        <property type="entry name" value="Exportin-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045546">
        <property type="entry name" value="Exportin-T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040017">
        <property type="entry name" value="XPOT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15952:SF11">
        <property type="entry name" value="EXPORTIN-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15952">
        <property type="entry name" value="EXPORTIN-T/LOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19282">
        <property type="entry name" value="Exportin-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 11" id="KW-0813">Transport</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="6 11" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Exportin-1/Importin-beta-like" evidence="12">
        <location>
            <begin position="137"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Exportin-T C-terminal" evidence="13">
        <location>
            <begin position="361"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF19282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI15306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1044" mass="115519" checksum="1327996612D04241" modified="2018-11-07" version="1" fragment="single">PVPSFASPSHSMEAQVENAVEILFAPGSDQPSDQSLKEQAFDFLNRLRADPHAWQPCINLFGRKPRASDVVRMACLDIVNLAVHSQRLDPDSLAYLKFALLGYVRDVYGSSSSSSSSSSSPLAAQNQEPAAAADSAAVQNKLTQTLTYLFAFHYHQGWQTFLDDFWQLARDSGSPPAVLLYLRILSSIHDEIADMLLARESNDAKRNIELKDRLRAHDMHKVAESWRLLLARYSDQDAVVELVLKVIGKWVGWMDISLVVSREMLCLLLPVVGRAGEDKVRDTAIDTLTEICGKKMRAADKMDMLSFLGLRDIVAQLIASRPLAELKGTPDYDTDLAEAVAKLVNTVMSDIVRALDDDQGTRAAAKRHLDDWLPFLLRFFSDDYDEVCSTVIPALTDLLTFLRKLGHPPPDSAATLVPILDAIIRKMRYDDTSTWGNEAEQTDEAEFQDLRRKLQNLQKTIAAIDQPLYVDMLSTLVANTFQTLESRGSAMDWRDLDLALYEMYLFGELALPNQGPGTKNQPSTEASERLVVMMQKMVDSGIADLAHPAILLQYMEICVRYCAIFESYPDSIPQVLEKFVRLVHHDHVRIKARSWYLFHRFVKQLRARVGNVAETVIRSIGDLLPIKAEVPSDEADDDDMSSDESDHSADALFTSQLYLFEAIGCISSTASTAPDQQALYARSVMDPLFGDMEAHLPRAEAGDAQAVLQIHHIVMALGTLAHGYSDWAPGSASGHHPPPHKAVSDEFSRAAEAILIALNQLNSSAEIRTACRSSFSKLLGVLGSAVLPQLPQWIEGLLSQSSSKDEMAMFLRLLDQVVFGFKSEIYDVLNMLLTPLLQRIFGGLSEPIAGTDDEIQLAELRREYLSFLQVILNNGLDGVLISEANQAFFEPMVSSIIELAATLDGNIGPSRLAFALMGRMSAIWGGGTADVVSAGQQPGAISPKPTIPGFDRFMVSHFQVACWSVMRNAAFRPWQDAQTKQVLTEIASLQQVMYGKTGEMLVAELRRDVFPAMGIDGEEYIGWLAGGDKKGFSSYLQGLLRARQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LM21</accession>
    <name>A0A367LM21_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3592</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LM21"/>
    <dbReference type="STRING" id="1330021.A0A367LM21"/>
    <dbReference type="OrthoDB" id="5218140at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="429" mass="47773" checksum="87FE6F08E45140A6" modified="2018-11-07" version="1">MITDANQGERVIGEAVDDVLLFGRFPFFPFVLSPFDAHDEAKLRHVASHLDSIHSRRQDMGVVESGPPPSLVRNGGSGIRNSRRDFFFLSLQTSFLLLSLTGTDEEKNIAIHGLAMMTPTNTTEKASRRRQQVKSAQVRHRQRKAEYTKHLELDAVRLRQLVAAVEDEVHGLKKRNEEMRRCLCEAEKAKMAAGNTTTQVVAWLDAPTGTDVSLGFHDAVNSPCLQIEGGGDWSLEEGTSMPPEVVEHRAVNFILALEHVCWDHFDPRDFNDPQPIDPTHGHTLMASAYLMATAPSSVYDSCPAIATAVAPDPTWRRLLRLPDTAVQRRKDAPVMRWPAPTISLDSLRGLAQSLNAGDVELTPVQIWFELAARYRPERLLRPDSIDALLRRFCGVVHCVAYGAAVERLVFESVVTAVLGPPEKRHLLHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LM92</accession>
    <name>A0A367LM92_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyltransferase family 69 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LM92"/>
    <dbReference type="STRING" id="1330021.A0A367LM92"/>
    <dbReference type="OrthoDB" id="262547at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021047">
        <property type="entry name" value="Mannosyltransferase_CMT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144:SF7">
        <property type="entry name" value="EXPORT PROTEIN (CAP59), PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11735">
        <property type="entry name" value="CAP59_mtransfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="412" mass="47123" checksum="08CB0719069EBFF1" modified="2018-11-07" version="1">MPLLSGDGRPLRLRRTLRWRTARLLVFFFCLFSLLEVLWVHNKLAMGDQQRSLTGQPHQRIYIASMHFNNGEILRNHWNDAVIRLTEEFGPANVFVSILESGSWDDSKELLRGLARELERRGVPHRVEISDVTHHDEMAKETKGEGWIDTPRNRRELRRITYLAKLRNKTIQDLVDLSEKGTSFDKVLFLNDVVFTTEDVLKLLDTNGGDYGAACSLDFSKPPHYYDTFALRDAEGNGHVMQTWPYLGARLSRNALVNHLDAVPVTSCWNGIGMALAMPTEPFVSSTRLRFRGIPDSLAAYHLEGSECCLIHADNPLSKSLGVYVNPRVRVGYNLAAYEATHRGAAWVSAWGVFRGLWSNRLRRWTEFRLKDVLVNRRVKRWEAETAGNHELGRFCLVNEMQVLADNGWAHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMA2</accession>
    <name>A0A367LMA2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMA2"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="228" mass="25564" checksum="ACB7D0B27F2BECB4" modified="2018-11-07" version="1">MPDTFYSQNPVPQTSPPCAIFTPIYSRANYQEHHHETFSHSLSLSPSSANALLTSEQGPLFVHQRNKKNVSLVIHWLPMAAVRRVMTRNSPNSSGPLLVTYLLSFLFWPAVRLQYYMSLDAVVIFSTPGPEPSLDGGKKPVYSLSQPEFVPRRYSLAYSPSLSLFFSCRQVTNLGTFSISQTKERKKRKRDGSRNIQRGERERGKSLRKVNGSAPGTSSGLRRASCDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMG2</accession>
    <name>A0A367LMG2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_3352</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMG2"/>
    <dbReference type="STRING" id="1330021.A0A367LMG2"/>
    <dbReference type="OrthoDB" id="1898560at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06466">
        <property type="entry name" value="p23_CS_SGT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1130.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007051">
        <property type="entry name" value="CHORD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039790">
        <property type="entry name" value="CHRD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46983:SF3">
        <property type="entry name" value="CHPADIPLOID STATE MAINTENANCE PROTEIN CHPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46983">
        <property type="entry name" value="CYSTEINE AND HISTIDINE-RICH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04968">
        <property type="entry name" value="CHORD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51401">
        <property type="entry name" value="CHORD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CHORD" evidence="6">
        <location>
            <begin position="5"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="CHORD" evidence="6">
        <location>
            <begin position="141"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="CS" evidence="5">
        <location>
            <begin position="218"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="104"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="110"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI15626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="35730" checksum="B2BEA7BEDF2F1345" modified="2018-11-07" version="1">MAQKCVRQGCGKEFTVVEEEECHYHPGPPVFHEGQKGWKCCKPRVLTFDEFMAIPPCTTGAHSTTDKPAQLEEGKQDDGATLAKKIEALTASAPPPTRVPIRQASATTATPPPPPPPPPPPPPPETDDDDPSLEIPDGAECRRRACGLKFNKGSSREGEKCLHHPGAPIFHEGSKGYSCCKRRVLEFDQFLKIDGCKTKSRHLFIGSGIKRKLDAEKLDSVRYDFYQTPTTVIASFFLKKINKDTSKVEFGSRQLSLDLTTSDSPPKRYATEVPLFGPIDTAASTHKMLGTKLELTLVKADGAPWPVLRSDEALTGEILQVGKAGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMX1</accession>
    <name>A0A367LMX1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SRR1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_1728</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMX1"/>
    <dbReference type="STRING" id="1330021.A0A367LMX1"/>
    <dbReference type="OrthoDB" id="5318346at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012942">
        <property type="entry name" value="SRR1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42080">
        <property type="entry name" value="SRR1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42080:SF1">
        <property type="entry name" value="SRR1-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07985">
        <property type="entry name" value="SRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRR1-like" evidence="2">
        <location>
            <begin position="77"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI15786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="266" mass="29457" checksum="D3C307796092F507" modified="2018-11-07" version="1">MTIPGEIEDASTWTFVRSRRRGRQKPPSPPPLVTSWKTATTPSSSSRTTSDLAAENDRLRSAWEQTSCCASLRRIVSSTACRVRHAVCLGIGTFDPDDGGWQTRRTSFLQLAAFSVMVEELAHIYMRLEKISGSPIQCVFQEPLFTPSDREFLAGLGHHVVDSPEAFRHISHDSFLFGVHLYRPVYAMALDAELPVVFVGTGWHVWESASLSQIEDLHNLQAMDRSYAKAAFPQDPPSTAFSGTTIYWRPTKVTSPTAICSVGPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LN48</accession>
    <name>A0A367LN48_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Triacylglycerol lipase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_1934</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LN48"/>
    <dbReference type="STRING" id="1330021.A0A367LN48"/>
    <dbReference type="OrthoDB" id="245563at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI15873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="215" mass="23195" checksum="F470FA8A931E28CE" modified="2018-11-07" version="1">MASRVLAISLHNESWFDEMFAPLLKAIRAKAEFQRAEDSTSALRLLSQQPKATAILITDQALTLQCNLAVWEAVLAYVSRGGVAVIMGLFPSFVKPDNMKPFFSKAGLPWAAGSYHRTILKLNRAVVDAASVEKLPQQYSQKAVFVNNVVPGDMWYRTDDDSVVQSAVFPPTDAHRPGETAVALAKVGEGKLGYVGDVNAEAGSNAVVLAMCGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNC9</accession>
    <name>A0A367LNC9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent DNA ligase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_2062</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNC9"/>
    <dbReference type="STRING" id="1330021.A0A367LNC9"/>
    <dbReference type="OrthoDB" id="2160351at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032807">
        <property type="term" value="C:DNA ligase IV complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029710">
        <property type="entry name" value="LIG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997:SF2">
        <property type="entry name" value="ATP DEPENDENT DNA LIGASE DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G02430)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45997">
        <property type="entry name" value="DNA LIGASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="7">
        <location>
            <begin position="376"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="678"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="743"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="678"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI15953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1012" mass="113047" checksum="C796DE4BFB01DCA0" modified="2018-11-07" version="1">MPLHFSLVCQLLDECERLCSTGKSNSKAVSDWFSHHRPSIHTLDVDLCALLSTLLPEKRTDRVYCIQVPSLEKIIARALMLGSSRVSELARYKQPGLGLDLADCVERILKSTPNPVSKSRDRVTVEELDALLNGLASASRWSSPAIRRSHKSVAQGNRGDIERIYRRLEPREAKWFTRLILKNFQPVILDSNVVFTCCHPLLPSMVKIQDDFAAAIRMLRHVKGDLLRESALAALADRTVLLPLKPQVGIKVGRQNWLKARSIKHCFNLGHGRMSIEEKIDGEYCQVHVDVTAKRPLVQIFSKSGKDSTEDRRALHGAIYESLRIGRPGCNFRSKCILEGELVVYSHRENKILPFHRIRNHVTRRGLFMNIEGDTRPDASEQLMIIYFDILLIDDRSLLDVRRCERFKLLQQTAHAVKGIADFVPRQVVDFGHPYAVSELRKAFAQVIVARGEGLVLKPDDPYFNFHRHDLPFAGHCIKFKKEYIGNLGDVGDFAVVGAGFDASKAKTYNIPNLQWTHFYLGCLDNKEQVLRWNAVPAFTVVAVVELNASQLKTVMSCGFPSPIRATENEATRLKIPKGIETGPPMLVTFGNPLVFDIRCFSFDKPGNTGFWTLRFPCVSKIHFDRDFRDTVSFDELQTMAQSATTVPEADDSQENLDWIARLEEADPRRLPVDAATQLTDTTISTPSPAKSTQVTSQRGSRASPIAISDDEDVSCEGSPRSSAKPLVLSPFQQVRLPSGCLRKRSTPLFDNASQTRKRHRSREPEEASRPAARHGSRRPLLDLSGNMSTLREATVSEVAKPVISHQVDENACGSDVEAFRTQKPVFQERNSAQGGVARVRDREAAYCSTSPSKLVKLCTYAASDCKLTACTILVSSASIIDDAEPAALLKAHGVLGSVTLADAWLKAAKEPEAGREDTTHQAANKHEAARDGSKLLLLVDTIGPDAAESKALVARIDKKHSDLPQHLRKWITVYDWRVLRNISIAEDESRSSRGNFDGFSDPWRRWQCGYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNE6</accession>
    <name>A0A367LNE6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Saccharopine dehydrogenase [NAD(+), L-lysine-forming]</fullName>
            <ecNumber evidence="4">1.5.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Lysine--2-oxoglutarate reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L249_1766</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-saccharopine + NAD(+) + H2O = L-lysine + 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12440"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:57951"/>
            <dbReference type="EC" id="1.5.1.7"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AlaDH/PNT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.7" evidence="4"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNE6"/>
    <dbReference type="STRING" id="1330021.A0A367LNE6"/>
    <dbReference type="OrthoDB" id="265306at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00034"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004754">
        <property type="term" value="F:saccharopine dehydrogenase (NAD+, L-lysine-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd12188">
        <property type="entry name" value="SDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027281">
        <property type="entry name" value="Lys1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF23">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE [NAD(+), L-LYSINE-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="14">
        <location>
            <begin position="9"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding" evidence="13">
        <location>
            <begin position="192"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCI15907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="423" mass="46780" checksum="E54553723CD5AEF5" modified="2018-11-07" version="1">MSSGYPAILLRAEQKPLEHRSFSPAVVRSLVQAGYPVRVERSSPDPKRIFDDNEYEAAGATLVPTGGWPDAAPGSALILGLKEIPEADFALTNDHISFAHCYKNQGGWDKVLSRFPRGRSTLYDLEFLVDEKGRRVSAFGYHAGFTGAALGIKAWAWQLSHPGGSEKLPSVASFTDGRGYYLNEGELVDQVRNDVVNGEKVLSRETPGRKPTVIVLGALGRCGKGACDLFIKAGIPEENITRWDLDETRERGDGPYEEIAQHDIFLNAVRLVFVFVSRLCRAALNCHVKLLQIYLSKPIPPFINNDLLAKPGRKLSVIIDVSCDTTNPHNPIPIYDINTTFDDPTVLADIKGDQNPGPLSVISIDHLPSMLPREASEDFSQGLLESLLQLKERKTARVWRDAEKLFREKVALLPEAMQRRNAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNH6</accession>
    <name>A0A367LNH6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zeta toxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_2997</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNH6"/>
    <dbReference type="OrthoDB" id="2881954at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010488">
        <property type="entry name" value="Zeta_toxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06414">
        <property type="entry name" value="Zeta_toxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Zeta toxin" evidence="4">
        <location>
            <begin position="34"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI15984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="315" mass="33573" checksum="2433C668B5967465" modified="2018-11-07" version="1">MMASSYRLSDAESQQIFRTRIVPAEVAAAPDPTSRHRQPFALLIVGQIGAGKSTLSPRLLAALRGEGEGGPVTHLVADAFKRYHPAYASLLSSSSSPPALASAATGPDARRWLIMAAEEVARRKGNVLIESACRYVEDFKTLLEIFGSGGGCYGLCVVFLAVPLALSRLGIAMRFYTGSESRLTPAVVHDQSCDGLLRAAAFVDGDDPAVAFRLLVLRRDGNVVFCPPGGLVDALTAERGRRLRAEERETVDRELGLLKTCGSGHAAKLADEIGALLLPLTEGGDDALTVVEVRPLEIKRGTGEDGQAWNVLRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNR3</accession>
    <name>A0A367LNR3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">glucan 1,3-beta-glucosidase</fullName>
            <ecNumber evidence="14">3.2.1.58</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Exo-1,3-beta-glucanase D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">L249_2717</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Glucosidase involved in the degradation of cellulosic biomass. Active on lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1-&gt;3)-beta-D-glucans, releasing alpha-glucose.</text>
            <dbReference type="EC" id="3.2.1.58"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.58" evidence="14"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNR3"/>
    <dbReference type="STRING" id="1330021.A0A367LNR3"/>
    <dbReference type="OrthoDB" id="62120at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000033">
        <property type="entry name" value="Glucan 1,3-beta-glucosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF34">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="18">
        <location>
            <begin position="328"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00036824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RCI15882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="691" mass="78107" checksum="9E985B46BD3B004E" modified="2018-11-07" version="1">MQAAFRRRDTMPRKESAVQGNRRRQGVEVSRKNTHRARKKPPQTPPTKSNDSSGERALSAAALAQLDRENARNNRKAQGRKRPIKREAEARPPRPPSPPSRPRPRPPPPPKAAKHRHDAHQRVGKKHKTRRVASGAAMEEGRAKRLGGDSSEDSFDKLDSHRRRRKRKSRKKLWILLGCSVVIVIIIIVVAVVVSKNKGGGGDSSLEGKDRDSIPAQRRNTYLDPWSWQTTTDFNVTFTEDTVGGLPVMGLFTEWDDSARANDQVPPLKEAWGSYGKRPARGVNLGGWLTLEPFITPSLFRRDGIIDEWSLCRQLGPSAAAKTLEEHYATFVTEDTFKAMAAAGLDHVRIPFSYWAVEVYQGDPYVFRTSWRYLLRGIEWARRHGLRVNLDLHGLPGSQNGWNHSGRSGVIGWLNGTDGALNGRRSLEIHDRLSRFFAQARYRNVISHYGLVNEPKMTFLAVNDVVTWTRSAYETVRRNGIDALVVFGDGFMGLEKWKGLMPSEMVLDVHQYLIFNENQIDFSHRRKVQYACAGWSQQADLSMDPNRGHGPTVFAEWSQADTDCARFLTGVGWGNRWEGTYDSGDKSTSVLTPRCPARDASCSCAAANEADASRMAPPYRRFLQHFAEAQMHSFERGWGWWYWTWKTESAPLWSYEAGLGAGILPRLAYRRDFNCDSDVPDFAHDGLPETY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNZ1</accession>
    <name>A0A367LNZ1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L249_2739</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNZ1"/>
    <dbReference type="STRING" id="1330021.A0A367LNZ1"/>
    <dbReference type="OrthoDB" id="5323195at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001097">
        <property type="term" value="F:TFIIH-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07977">
        <property type="entry name" value="TFIIE_beta_winged_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000002">
        <property type="entry name" value="Cytochrome b5 type B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054600">
        <property type="entry name" value="TFA2_E-tether"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040501">
        <property type="entry name" value="TFA2_Winged_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016656">
        <property type="entry name" value="TFIIE-bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003166">
        <property type="entry name" value="TFIIE_bsu_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12716:SF8">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12716">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22254">
        <property type="entry name" value="TFA2_E-tether"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18121">
        <property type="entry name" value="TFA2_Winged_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02186">
        <property type="entry name" value="TFIIE_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51351">
        <property type="entry name" value="TFIIE_BETA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 13" id="KW-0349">Heme</keyword>
    <keyword evidence="6 13" id="KW-0408">Iron</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="15">
        <location>
            <begin position="9"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIE beta" evidence="16">
        <location>
            <begin position="253"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="214"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="429"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCI15962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="468" mass="51125" checksum="29CCB78CA86D2C17" modified="2018-11-07" version="1">MDSSSSAMSEGFTYQDVAEHNTKKDLYLVIHDKVYDCAEFVDEHPGGEEVMLDVAGQDATEAFEDVGHSDEARETLDKLLVGKLRRQSGDPVPQVVPQTSSTSGSSSDQNGLGMGLYVILLIGSALGYLAYYYHHGADDLPPVSLRPSASRSPTPWDVSPPFEIVSSTSRFAMSSYLEKQSSAFRGTLASAASKLSNAKAAAANANSSSMLKTATAASLAPPSPSPSAASDSATPSGKRKRETMPEVPFSQPQLTGYGSEVKTQMTFAVEYLKKKGDQKSMTDIIDHLSLQSQPEDHKRELAEGLRGHPRIEWRPDESLTEQTWRTGTYVHRPIIPGVRDGTSLLAFLQRKTDASGVAVKDLKDGWPDCEETLASLEKQNKVLVVRTKKDNFPRHVWPDDASLKHVVQAEFQARWHAVPLPSLEDMHRKLVSVGQKPTSEDPRKLAQALGSKPKTQKKKAGKKQPTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LP05</accession>
    <name>A0A367LP05_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_3217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LP05"/>
    <dbReference type="STRING" id="1330021.A0A367LP05"/>
    <dbReference type="OrthoDB" id="3600127at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016603653" evidence="2">
        <location>
            <begin position="18"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="275"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="334"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI16111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="468" mass="47841" checksum="F852F62C1D582D00" modified="2018-11-07" version="1">MKRVVALSAVAAGIVSGWKYPDCEHDNCYRNLLDRRFKNLAPTFCIDFISDLRTDPLDIHQEFRLNCGEDVQKVSSACSCIAYTATHASQPSKATTTTGRWTTSTISTTQTYTVTTCPPRVIHCAGKEHTTVITKTIPISTTVSAITSTDQTPASSSASLQPGATTSDQPGMPSGGQPQPTSWTTSTIHSTRIHTVTQCPPDVTDCPNRGHTTVITETIPVSTTPTSWTTSTIHSTMISTITRCPQGQAECPGSEQTTVITESVAVSTTVCPVQPTGQPGMMVPPVPIPGQPEKTASGPGETASVAPVPSQPAASGPPAASGPVPTQPGQSYVPAPSQPAGSGPAPSQAVQSYGAAPSQPAASAEEPSGSGPQYMTQTLAVPSCSPGSPDCDVESAPASTLASMVKPSSAAQQQQPETTMYYGSTTPSTGGVSASSTASPVLVTGAAGRVSSSGVKAMAVVVGLVALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQ44</accession>
    <name>A0A367LQ44_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_2275</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQ44"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI16507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="142" mass="16303" checksum="CE55E28104DC4863" modified="2018-11-07" version="1">MYVYRIHTQPAVESPPPHATEQDHALLSSYISATDTALFILLSTVPYQPPNPRHVLNVEEEEERRKTLLGGVEEKSVLISRGTTKKKRTKKNDLYQLTKEEEEKKMREKKKFPPVGYQKGIECVGRLDVAAPKYGLPREEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQH9</accession>
    <name>A0A367LQH9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_2963</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LQH9"/>
    <dbReference type="OrthoDB" id="2018507at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14037">
        <property type="entry name" value="STKc_NAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000441">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967:SF57">
        <property type="entry name" value="AUXILIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22967">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="52"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="335"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="447"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="760"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1324"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="343"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="470"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="503"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="524"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="534"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="567"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="601"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="631"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="668"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="707"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="814"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1329"/>
            <end position="1350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI16678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1350" mass="146508" checksum="F89E7E7CCE8A0504" modified="2018-11-07" version="1">MASYVHHQQQMPPRSAQRQPAPGSQQRPPFVPAAPTGTFSPGTKIQVGSHRVVIQKYLSEGGFAHVYLVKMPQPVDGTDLAVLKRVAVPDKDSLRSMRTEVETMKRLKGHHPIVTYIDSHASEMRGGGYEVFLLMENCNGGGLIDFMNTRLQHRLTEPEILSIFADIAEGVACMHYLKPPLLHRDLKVENVLITSRGASKRFKLCDFGSAAPPRPAPTTVVECRLMDEDVQKHTTLQYRSPEMIDVYRKQPLNEKSDIWALGVLLYKLCYYTTPFEEQGQLAILNASFRFPSYPVFSDRIKKLIASMLRESIEARPNIYQVLKEACTMQGRQVPIYAGRPQTGPRNNNQTSTESKPQPKVGAVYSAPVREKPQEIPQVAPMRRGRPNPSHEASDTHGSPPKKVTGGDPFAALDSKDGAQLDADELSSRFPTLDQFSLLHDKGAKFDFDSAAVSPPTESGPGQRATETRAKQSSASLEKSSAEARASQGSRNAPAVLDRDRPNQGRNANYVSTGTMTSLESVESVSRRADKGRTESGTVPSQSHSAHIRRPSPSSRQSLDEARPPVPTAAAASSASQSRPRPQSSLLESNTAGFVRERDSPKAQTGSGRPLSRGSQVKSTSSPKPTARPDGNMSTSDLIDVNGTDSKPVQKSGGPSPSYTAPPPKKIVGKFEDAFKRFEGSGGQDTTPVAGSETRNDGGIDDDQATPEMRRELERRQLEEEEQRVAAAQAEYKKRVAGDGALGSRRAGNVARSATIQSRVQSLLEEEQRPSPVQRTAEGYGKYTDAAKGANKDKTLPTLRQKSPDGFQSKANAEPPSTSSTITTKPAISRPTAPKKPVHLNSTLPGARPPSPAKRSQPEFLMAQDLPGQPVLEMSAQEKEDYIKEFAKRFPSLNTVELEAMAASRDGADFADTFLFNAHASAIRCVAVSPPSAPVPGQRQKVLLASGSTDERINVYNLSAHPPRTNDNDVLAKVAPRPILESRKNRELGTLLHHASTITTLRFPTRSKLLSASEDSTIAVTRTRDWSVLSTIKAPVPKAQGRPSGDTAPLGATPSGVNDFAIHPSMKLMISVSKAERCMRLWNLVTGKKAGVLNFDKAMLQEIGEGRHSTGEGRRVVWGHADGADEFAVGFDRDIIVFGMDSVPKCRVMAATTTATTTKTAAAARTKIHKFTYVTIDNASEKSLLCVSTEDGRIIFFSTRSEDLSDPDPSHQGSTLRTARAVGQVGGRCSSSSSSSSSGTGVTGVTGRIKDFAVVRGEAADNDKINNDGIYLVGGGSDGKIWLWMVRLSELVPNGTLEGGQVGRLLGVYETHNRVTCLTAFMMIERPEGVEDSENEDEEDEEEGEEEEEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQU2</accession>
    <name>A0A367LQU2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_1946</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQU2"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI16816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="43" mass="4901" checksum="56CA718580488D42" modified="2018-11-07" version="1">MLRTRLLNASMLNSSYLITSPPLLSTPSRSFCLRRLYLIGRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRC6</accession>
    <name>A0A367LRC6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRC6"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI17004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="70" mass="7630" checksum="5AC8EAF556D4D62C" modified="2018-11-07" version="1">MGYVRVLQVGTLKYLEKIISISFSHLLNTNTSPASNSSSIASFRPSRDSSSSSLSRNYLPDSSTLHPLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRN0</accession>
    <name>A0A367LRN0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_1807</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRN0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI17103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="133" mass="14833" checksum="6DA603F3ED01BD63" modified="2018-11-07" version="1">MRESMYPRQRFNMTETISVNAAEPLVFNVRLNRENPPSQGSQQPPTYICIYGPRSTDDSAAVKEMQGCLSLASLKLGSGTYPILSHPILSHPMSVEAKEESFYIESIVVIIHLPVQLPRQPFIPYLLVSTGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRR2</accession>
    <name>A0A367LRR2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_3056</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRR2"/>
    <dbReference type="STRING" id="1330021.A0A367LRR2"/>
    <dbReference type="OrthoDB" id="566138at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678:SF37">
        <property type="entry name" value="AMIDASE C869.01-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016685719" description="Amidase domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="76"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI16922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="586" mass="65044" checksum="E80870A0111CB1B3" modified="2018-11-07" version="1">MRSQVVLLWLGLLLAKHGVLGLDRERFIVDTYSPPYRPSILLKMQMPLCYGLQLEEASIDLMQDWMENGLITSKQLVECYLRRIYQTQEYAGSMIEINPDALSIAQARDAERKRHLVRGPLHGIPFTVKDNIASKDKMQTTAGSLALMYSVVPADAHVLDRLRRRGAVLIGKAAMSEWADMRSTNYSEGYSARGGQCYSAYNMTVNPGGSSTGSAVGVSINAVAFSIGTETDGSILNPAMRNSVVGFKPTVGLTSRYGVIPESLNQDSVGTFGRNVKDAVLALDAIYGLDRHDPATKAMCNQTTVPSPYDRNGFQQFLTNRFALGNRTLAGRARFGIPWNSFWVHADPETRDVLLKVVSTLAKAGARIINNTEITNYQDIVSPTGWDWNYGSSRRWANRSEYTYVKVDFYRNIETYLSKLGNTSIRTLQDIVDYNNDNSHTEGGIPGTHPAFYSGQDGFNASLATGGIMNDTYHQALEFCRTSARGGIDDALRWKNRQLSALLVPLDPGQSYQIAAQAGYPMMTLPITVHSQSAMGIGLGLMHTAWHESELVKWSSAIEDLLIHENYVRARPLWRGHDQRKIPLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRT2</accession>
    <name>A0A367LRT2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_1758</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRT2"/>
    <dbReference type="STRING" id="1330021.A0A367LRT2"/>
    <dbReference type="OrthoDB" id="10047078at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003962">
        <property type="term" value="F:cystathionine gamma-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051750">
        <property type="entry name" value="Trans-sulfuration_enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699:SF1">
        <property type="entry name" value="CYSTATHIONINE GAMMA-SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH16" evidence="3">
        <location>
            <begin position="315"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI16942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1211" mass="134464" checksum="3B6A3AA63DF3F06A" modified="2018-11-07" version="1">MLFRDIMVAVSFAMGKVTANHGRWDFHDRNATSSKISPREVRLAFPARDPGIIARENLTQGLFLPILFNPLWPAGTNLTTSHPLDWLGYPLNENSSLGVKIMRTLPVGLRIDIAQSKGWDAATFIAEVDYALSLLPNVKAVKNWYIRHGSVGQRICWDKDVPSVLDSHSNVVGGLSSLIVRPEQVRYDLPARRFYPDLPPWYMARGSPHCINKSNPHYETVRKVILNSLSFNFHPRQTGADYLDIVRCRLRDYAHPMLRAIYYASLKNYECPYKKSCFWYSATKGKHYRTMTPPNFFGFAKVLQGLFRNREPICLLFGNIPAPVARLLPRNVSPTTPDGFTRCLFHDDFTDPDAGSLPSSAKWTLALGTSYPGGAAQWGTGEVQNYTKTNIQVTADSTLLITPSRQQDGSWTSSRIETTVDWDFACQPNHRIRVEARIKLGDDARTKQLGIWPAFWALGASVRKNPTAWPTIGEVDVMETANGDTAMRHAVHCGVAPGGPCNEFTGIGTVTESVNRGEWHVYAWEVDRRAGKGLEILTWFVDGSQRWRMEKQAIANDDGSAWDVLVAGEKMLLLNVAVGGAFPDALAGGKTPTDATAGGRGASMETGDRSWEELFWWLLGLPNITWSGSDKTWTDSRLRPQQFWSHLLGRHASFAVAMPDIVLSGAAGVTTPFGDAVPPAPRHAITVHMPGFATAERFGKDPPSVIAHFKSVYPRMRPHQDIARLIDAVLARLHIPERACLLFASRQSADECVAYASSPKREDGCTKHPVSPELMSVHAFIAKDVFFAVVFPPEARTVVGGFWVTPGCGVSSRFAEANLRHLDQLAEIGDKTVGRPGFDGLDHRLLRERIIALLARAPLVRSPPRQQPGPSIGDVYFFQTGMASIYKTHSYLLSLHQGTTVLFGMAFMNTVTIFEEFGSSYKFFGLGTDQELDELGVFLEGERSHGRKVQAIWTEFPANPLLVTPDLIRLRSLADEHDVVLAVDDTIGGYANVDVFHHADLLVTSMTKSFNGYADVIAGAVVLNPSRPKYRELKPLFERCHVSELYVDDAKAIERNSRDYLSRCGRLNDNALALVQHLNSYSKDPASSVRHVFYPSVNDSRQYYERFMRPATTDFSPGYGCLFSVELADVASAKAFYDNLAVHKGPHLGAPFTLAFAYTVCGYMTRLDWAAGYGLKPTQIRVSAGLEDTETLIELFSVAVEAANRARERRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LS34</accession>
    <name>A0A367LS34_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_2449</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LS34"/>
    <dbReference type="STRING" id="1330021.A0A367LS34"/>
    <dbReference type="OrthoDB" id="9996895at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF21">
        <property type="entry name" value="ATPASE FAMILY AAA DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="586"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="685"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="904"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="702"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="907"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="924"/>
            <end position="937"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI17228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1186" mass="129856" checksum="C78773E916C9574E" modified="2018-11-07" version="1">MPMGSVLVAAMARGRIGKSPSDKVHPFFSKATGKDASPGYQMIHAATSVDDNSALNGGDENRRKKRRKTESEALDSDPEPRKSRRKKGHGPLRDSPTSSAIASPLAKQSQSSSAPGPQASATCNSTSSASRSLATEQPTESELPNPQSSGETAQLLEAPRQNMRYLKFNPKTGTLGSPPKQNRSNSPSMLVHIQYGHDDETRRTVGAKVTQILTGERQMPDDQTGDDDNSSLHVCKSALRKQDQDQKTTHPFFFGKSRSLVSSEQSKSTVPTQRPAACKNSVFMSTPVSPRKQRNPFTPTSSNNMVKFGIKSTGVKVPGAMYPMWPAAGMSHVRGPDVRSDSAVFDPGSPLSKKSKGIVTAITPQESILARLLDLLDLQSVHRSLPRDEECFAPAPPELRLPRRRFESGRVLQKWIRSRLAPSLLAPSGPDELSEDDHSVSPIPKAHAAIFRHYHSLLTNLSAFDRSTCENQAWAQKYAPTTAAQVLQAGKEMTLLKQWLEALKVQSIDTGSDGGSDRSKIKCKPRRKKRTKLQGFVVDSDDEANGIDELSGVEDEPNMADAGSNKRSLIRTGDTDFRSSRDSSRLRNTIVISGPHGCGKTAAVYAVAKEIGFEVFEINSGSRRSGKDILEKVGDMTRNHLVQRHKNQPPSATAAVVETDEKCKGSKKPMLRGLMSSFLKSKPATVKAKATTHKAKKDKSETSPATSAPQSQKQSLILLEEADVLYEEDKQFWQTLVGMMMQSKRPFVVTCSDESLIPLQSLNLHGIFRFTPPQPRLAVDVCLLIAANEGHALERKAVESLYRSRGDDLRATISELNYWCQTGIGDRRGGSDWFYPRWPKGSDVDAGGDVIRVISEGTYLRGMGWIGRDPFATAEPREAEEDALRQAWDSWQVDMGDWSSWCDVEVSTPTKPSSPSSSPPPPSSSSSSPSSSSTSSSSQCRAKVKALAAYDEFCCAMSGSDLCAGAAFGNLLQEPIDCTLPHLPSGVRDDYIIGRTLLEADSMTSMRSTTRDMAITIKSLARASLVCSADRRSIMRQPKAVDELRATRMLDRSFRTGQRQLTRHDLSLAFDPIAASAKTQTLSHLEPSVFDRTLRLIVLDVAPWVRSIIVFERQLMRDRVKLSNLLSQGGKRRRTTRAAYSALEGGERRTTRREKYFGSGLSSEAVMLTGATSFVQGEGHDAAEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LSP7</accession>
    <name>A0A367LSP7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_2791</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LSP7"/>
    <dbReference type="STRING" id="1330021.A0A367LSP7"/>
    <dbReference type="OrthoDB" id="273556at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16457">
        <property type="entry name" value="RING-H2_BRAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011422">
        <property type="entry name" value="BRAP2/ETP1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047243">
        <property type="entry name" value="RING-H2_BRAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24007:SF7">
        <property type="entry name" value="BRCA1-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07576">
        <property type="entry name" value="BRAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="340"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="UBP-type" evidence="7">
        <location>
            <begin position="376"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="21"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="151"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="296"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="474"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="564"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="668"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="172"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="307"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="578"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="668"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="685"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI17429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="694" mass="77481" checksum="C7263DD16384231D" modified="2018-11-07" version="1">MMRTIKPRYYYHLKFELYPSPSPESAEQTGSIWLPPPQASAFDHLPSHPRQNDRRGARAKPRGGGGIKDRGRRRRRIHDWRFGRVSIETADPTTSEMAPSEPGKPASSAAPTLGPSLGGAGTATKAECLSLDTKHTELGWGVVRFYRDGEETPTATCEDGETTAHVEKGDKEEEEQEEEEQEEEQERMMMMMMKKKKKKKKKEEEEEACCVLCIPAVPAYMSPGDFMGFVGDRWMGDISHCRMVMTSSMNRFLVLLRFRDAERAKLWKHEFDGKVFNSMESRVCHVVMVKSITFETPTEPRRKDQPAAAQSSSSSSSVAVSSSLKPFPPPTPNLIELPTCPVCLERMDETNGLMTIACSHVFHCTCLQNWRGGGCPVCRFTNASSHEDGDDPNSKSFGAPVSNLCSVCDCADDLWICLICGHVGCGRYKGGHAKDHWKETAHCFALELETQYVWDYAGDMWVHRLIRDKGDGKVVELPERGSPHGGQGREQQQQPRDEDVVPRAKLENIGLEYTHLITSQLESQRAYYEDMISKAADKAAAAASAAESSTARSAETARRLDRLEEGYRTLSSETVPQLERDLERQRGRADRAETLARKLGQSLQEEKRINEGLMQRIAHLGSEAEALRGQMAALGKENEELKESNRDLGMFISGQEKLKAMELEGTLGEGEAAEGSVGVAESGSRCRRRQRNKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LST0</accession>
    <name>A0A367LST0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_2934</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LST0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI17459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="84" mass="9885" checksum="B2FC0D0EBF91B15C" modified="2018-11-07" version="1">MKGYEKKKKKKKEGNNTGSEKTENKYREKKNKIREMPISICLGRTPLFFSLSHLLVCKWTMMMDDDDDDDDDDDDDDDDDDDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KYY4</accession>
    <name>A0A367KYY4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10 11">Catalase-peroxidase</fullName>
            <shortName evidence="10">CP</shortName>
            <ecNumber evidence="10 11">1.11.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Peroxidase/catalase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">katG</name>
        <name evidence="13" type="ORF">L249_1379</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 10 11">
            <text>2 H2O2 = O2 + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:20309"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10 11">
            <text>H2O2 + AH2 = A + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:30275"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="EC" id="1.11.1.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="10">Binds 1 heme b (iron(II)-protoporphyrin IX) group per monomer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10">Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10 11">Belongs to the peroxidase family. Peroxidase/catalase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.21" evidence="10 11"/>
    <dbReference type="EMBL" id="LKCN02000031">
        <property type="protein sequence ID" value="RCI07384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KYY4"/>
    <dbReference type="STRING" id="1330021.A0A367KYY4"/>
    <dbReference type="OrthoDB" id="407695at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004096">
        <property type="term" value="F:catalase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070301">
        <property type="term" value="P:cellular response to hydrogen peroxide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00649">
        <property type="entry name" value="catalase_peroxidase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08200">
        <property type="entry name" value="catalase_peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000002">
        <property type="entry name" value="Catalase-peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000004">
        <property type="entry name" value="Catalase-peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000002">
        <property type="entry name" value="Catalase-peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01961">
        <property type="entry name" value="Catal_peroxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000763">
        <property type="entry name" value="Catalase_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00198">
        <property type="entry name" value="cat_per_HPI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011635">
        <property type="entry name" value="PRK15061.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30555:SF0">
        <property type="entry name" value="CATALASE-PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30555">
        <property type="entry name" value="HYDROPEROXIDASE I, BIFUNCTIONAL CATALASE-PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00460">
        <property type="entry name" value="BPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10 11" id="KW-0349">Heme</keyword>
    <keyword evidence="6 10 11" id="KW-0376">Hydrogen peroxide</keyword>
    <keyword evidence="5 10 11" id="KW-0408">Iron</keyword>
    <keyword evidence="3 10 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 10 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 10 11" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="12">
        <location>
            <begin position="128"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="10">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="91"/>
        </location>
    </feature>
    <feature type="cross-link" description="Tryptophyl-tyrosyl-methioninium (Tyr-Met) (with Trp-94)" evidence="10">
        <location>
            <begin position="241"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI07384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="760" mass="83200" checksum="21A369AC34762C83" modified="2018-11-07" version="1">MVAEEKCPARRLMNVAGGGTSNSDWWPDALRLDILRQHTAGSNPLGPDFDYAAAFKSIDYEALKRDLRTVMTDSQDWWPADFGHYGGLFIRMAWHSAGTYRVVDGRGGGGDGQQRFAPLNSWPDNVSLDKARRLLWPVKQKYGNAISWADLMILAGNVALESMGFKTFGFAGGRPDTWEADKSVYWGGENTWLGNNVRYEKGRDGLSKHGVIVSDENPDGKPMHSEKLESPLASAHMGLIYVNPEGPDGNPDPVAAAHDIRVTFGRMAMNDEETVALIAGGHTFGKTHGAAPASNIGDEPEAAGLEEQGFGWRNCHGSGKGPDAITSGLEVTWTKTPTKWSNSYLEYLFKFDWVLTKSPAGASQWVAKNAEPIIPDAHDASKKHLPTMLTTDLSLRYDPEYEKISRRFLENPDQFADAFARAWFKLTHRDMGPRVRYLGPEVPAEELLWQDPIPAVDHPLVDEADIAALKKEILGSGPSLSDLVFTAWASASTFRGGDKRGGANGARIRLAPQKDWNVNNPERLAKVLQHLEAIQKRFNDGQKGGKKVSLADLVVLGGCAAVEKAAADGGCATAVPFTPGRMDASPEQTDVSSQGHLQPYADGFRNYGQSTPHVKLEFLLVDKAHQLTLTAPEMTALVGGLRVLNANHGGSPEGVLTKRPGVLTNDFFVNLLDMGTVWKASGPNADHFEGCDRKTGNKTWTASRCDLIFGSHAELRAISEVYGSADSRQKFTKDFVAAWDKVMNLDRYDLNRKETRASRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZ72</accession>
    <name>A0A367KZ72_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine aminopeptidase S33 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000028">
        <property type="protein sequence ID" value="RCI07468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZ72"/>
    <dbReference type="STRING" id="1330021.A0A367KZ72"/>
    <dbReference type="OrthoDB" id="94039at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="1">
        <location>
            <begin position="113"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI07468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="396" mass="45189" checksum="BFC15AA0E58469D0" modified="2018-11-07" version="1">MPRTVHFNIQEHIISGCHVRQYPGLTSGRQEEDMRLHVKQYTPRNQPLESSDAVTLIAMQGIGFPKELYEPLWDHLHHHSRSHGYCIRSIWMADMAPQGISGILNEKNMSMDNSWEDHTRDVFHMINHFRNEMPRPLVGVGHSCGGLQMANLAHIHPRLFTTVILMDPAFLVNEKGEIIYPEKAIRDITHGKDLWRTRAEAAAFVEKTYPAWDQRVKRRMIQYGFRDLPTALYPELPPEADVADPPVTLTTTKHQMAMMLVRPCFDGLDHVDAKRRTNKSFHRPEVVPSAERMKTLRPPTLFLLGRHTNRRWLEAIRRTADATGLGVGGSGGKPEGRVREVMVRAGHAFPFTAVGETGLACSAWLGEEMGTDHLVLPLKWKEMFRPRDDEAARSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZ88</accession>
    <name>A0A367KZ88_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Association with the SNF1 complex (ASC) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_4554</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 5'-AMP-activated protein kinase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000028">
        <property type="protein sequence ID" value="RCI07476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZ88"/>
    <dbReference type="STRING" id="1330021.A0A367KZ88"/>
    <dbReference type="OrthoDB" id="531008at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000562">
        <property type="entry name" value="Snf1 kinase complex beta-subunit Gal83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.250.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006828">
        <property type="entry name" value="ASC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037256">
        <property type="entry name" value="ASC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050827">
        <property type="entry name" value="CRP1_MDG1_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343:SF84">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04739">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01010">
        <property type="entry name" value="AMPKBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160219">
        <property type="entry name" value="AMPKBI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Association with the SNF1 complex (ASC)" evidence="5">
        <location>
            <begin position="340"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="306"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="82"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="331"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI07476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="452" mass="48615" checksum="D54E2DAC5C18D8F0" modified="2018-11-07" version="1">MGNSHSTSQKSATAGASSPTASQPLPPHLHHHSDSARGPRREARNIIPPHTPHRSAAPPEASLAQAHGSTVVSWPKSLPGTAVSSLSGSPHSNVSNAARAARDEPSKPVDVPADPATSRGPQSYHHHLLQTQHNTHDSPLVHNNSATDMYLRGPPRLPLPIEEEVHTPGSPILPPDQDFGDIDLGEASDGLTRKGSALSANTVDDEESEELRVDKTRPVVPTRLEWRRGGDKVYVTGTIFQWNRKQRLHPVDGKPGCFAATIHILPGTHHVRFLVDGIMQTSQDLPTTVDFGNNLVNYIEVNPDDVPAAQKPGGGGVSSGSASRTSSQAKEATRQARGRPVDAPESYRNEIPQYLLDFDQPEDSAAYRNAVAAIEKLPTPPSLPGFLGRPILNAATLMKDDNSVLNMPNHTVLNHLATSSIKNNVLAVSATTRYRNKYVTTIMYKPTSADEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZH7</accession>
    <name>A0A367KZH7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_1643</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000026">
        <property type="protein sequence ID" value="RCI07593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZH7"/>
    <dbReference type="STRING" id="1330021.A0A367KZH7"/>
    <dbReference type="OrthoDB" id="941679at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF14">
        <property type="entry name" value="FAMILY 17 GLUCOSIDASE SCW10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="57"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="94"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI07593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="390" mass="42267" checksum="672B47F66313C159" modified="2018-11-07" version="1">MALVGRFILPAIALRAVDEHIIDVSATITVDEDGRVVQEQTTDIVVTTTLVDSPAVASQTPVYSVDTTQTPQIPQTPQTPQTPSAATENLYHSAVSSSSQTPRSDSYGQASKGSAYNAKPVTTTKGNATESASNKLFGIAYAPYRADHECKSADETKQDFQIMGQFYSLVRIYGTACADESNFFEAAKAHNMKVFLGIWDTKSIEKEVEAIRKIVNGDWGYIHTISVGNEMVNSGQAEASEMVKAVNDARRRVREIGYTGPVVTVDTFGAYKNNPDLEKASDYCAFNGHGFYDSTNPANSTGPWLKKVVKDSCQNLENAVVAESGWPKRGISNGKAVPGVEEQAAALRSITEVFPTDAENGVKVILFSAFDDKWKDPGLFNVEQSWGIHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZK8</accession>
    <name>A0A367KZK8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Tyrosine specific protein phosphatases domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_1647</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000026">
        <property type="protein sequence ID" value="RCI07597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZK8"/>
    <dbReference type="STRING" id="1330021.A0A367KZK8"/>
    <dbReference type="OrthoDB" id="428974at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140096">
        <property type="term" value="F:catalytic activity, acting on a protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004484">
        <property type="term" value="F:mRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14502">
        <property type="entry name" value="RNA_5'-triphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000090">
        <property type="entry name" value="Dual specificity phosphatase catalytic domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051029">
        <property type="entry name" value="mRNA_Capping_Enz/RNA_Phosphat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367:SF25">
        <property type="entry name" value="DUAL SPECIFICITY PHOSPHATASE CATALYTIC DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G03540)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="2">
        <location>
            <begin position="541"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI07597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="623" mass="68649" checksum="5EB248889AB40EEA" modified="2018-11-07" version="1" fragment="single">LKASANAQLHSQDVYGQRGGVDDDPQAMAAARDSTAANWAVNCTDAHLTDPALLREHSQFKTYTTSRFRYPNIRVFFRPHAKAKELPSPLPLLVCIPGLGGSVAQFHPLLSSLVDLAPCLAIDHPGGGRSDYAVTSWDAYTPLALVELLALVIEDFRDADANQGVVLIGHSLGTSLAAALARPLNESTAAYVRRLLWIPGWLFSLWRLWDGIGGLESRSVSRFVGPDAEPELRLLQYRFNKQSRTPVWRRMAYGALAKYVHHKPVGGVPGLDVWAGIRAPVFLIAGEDDHVTPPEAVDMIEQALREAQSVRGKDADGVVEEEGSEAAAPLGFSSSSQDDHPHTSDGAPQDSPENGALTDDDDMQEDPSTPVEAFGGLPVPLPPQPRRPRQVIRSRVMPAPANHALLYMPRTARALAGFISDFLATSITQRLSLAWQLQYLSREGKWDVKNLNKWKSVPPVSDVIGPVGEPVFRAMKTLREADDVHCPTVFVETWGAFIKDVVDISKDQPVYDPRGLERDGRVQYHKFPTVSKIPPEAHEIEAFIRLVDGIRRKRAAQGLESAVVGVHCHYGFNRTGYFIVCYLVERCGFTVPKAIEAFAKARPNGIRHSHFLDRLYVRYSIGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZL7</accession>
    <name>A0A367KZL7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">argininosuccinate lyase</fullName>
            <ecNumber evidence="4">4.3.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Arginosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_1610</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2-(N(omega)-L-arginino)succinate = fumarate + L-arginine</text>
            <dbReference type="Rhea" id="RHEA:24020"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57472"/>
            <dbReference type="EC" id="4.3.2.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.1" evidence="4"/>
    <dbReference type="EMBL" id="LKCN02000026">
        <property type="protein sequence ID" value="RCI07633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZL7"/>
    <dbReference type="STRING" id="1330021.A0A367KZL7"/>
    <dbReference type="OrthoDB" id="2561043at2759"/>
    <dbReference type="UniPathway" id="UPA00068"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004056">
        <property type="term" value="F:argininosuccinate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042450">
        <property type="term" value="P:L-arginine biosynthetic process via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01359">
        <property type="entry name" value="Argininosuccinate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000002">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000001">
        <property type="entry name" value="Argininosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000025">
        <property type="entry name" value="Argininosuccinate lyase chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00006">
        <property type="entry name" value="Arg_succ_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029419">
        <property type="entry name" value="Arg_succ_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009049">
        <property type="entry name" value="Argininosuccinate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00838">
        <property type="entry name" value="argH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43814:SF1">
        <property type="entry name" value="ARGININOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14698">
        <property type="entry name" value="ASL_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00145">
        <property type="entry name" value="ARGSUCLYASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="6">
        <location>
            <begin position="18"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Argininosuccinate lyase C-terminal" evidence="7">
        <location>
            <begin position="376"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI07633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="471" mass="52535" checksum="0E34BEA02D58FD39" modified="2018-11-07" version="1">MTGSAKAEGEGGSMLWGGRFTGSLDPLMVTYNESINFDRALYKQDILGSIAFARANAKAGIISAEEFKQMERGLLQVQKEWEANEFVVVPGVDEDIHTANERRLGEIIGKHVAGKLHTGRSRNEQVVCDMRMWLRDQLRSIELHLVDLLNVLAARAEREMHILMPGYTHLQRAQPIRWSHWLLSYGFAFASDLQRLRELTRRVNRSPLGCGALAGNPFGIDRDMMAKELGFEGLLWNSMGAVADRDFVTEALQWGAMLMQHVSRWAEDLVLYSTAEYGFVRLADAYSTGSSLMPQKKNPDSLELLRGKSGRVFGQMAGFMMVQKGLPSTYNKDLQESVEPMLDLVKTVADSIQIANGVLSTLTTNSDRMRAALDPFMLATDLADYLVGKGVPFRETHHISGKCVAKSEETGIPMNELSYDQLKAIDSRFGKDVAHVFDYDACAERRTAKGGTCKASVEEQIEVLRDLLKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0J5</accession>
    <name>A0A367L0J5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_7839</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000022">
        <property type="protein sequence ID" value="RCI07948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0J5"/>
    <dbReference type="STRING" id="1330021.A0A367L0J5"/>
    <dbReference type="OrthoDB" id="552049at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000028">
        <property type="entry name" value="DnaJ domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026894">
        <property type="entry name" value="DnaJ_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052814">
        <property type="entry name" value="Peroxisomal_DnaJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45006">
        <property type="entry name" value="DNAJ-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45006:SF1">
        <property type="entry name" value="DNAJ-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14308">
        <property type="entry name" value="DnaJ-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="460"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="123"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="155"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="173"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="460"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="481"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="505"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI07948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="516" mass="57869" checksum="4D001465505AB20A" modified="2018-11-07" version="1">MVVDTAYYDTLGVQPTATQLEIKKAYRKLAIVHHPDKNPNDPTAHEKFQAIGEAYQVLSDTDLRKAYDKFGKDHAKPSEGFADPAEFFSSIFGGEAFADWIGEISLMKDLTATMDITMQGQQEETDKDASDEADEEAKKQSTKEQKSAAEGSPAPESPPNKPPPVPPRNPTVEQEKPADRRDTSSPSSSSRTKTQIPLRQALTEKSHDDTLGDASDEASLRQKEKKKGGLTKEQREQLAAFEKERARVRKERVDVLSKKLLDRVSVWTETDKSSDVTKAFQEKMRLEVENLKMESFGIDILHAIGQTYVSKASALLRSQKFLGIGGFFSRLRDKGTLVKDTWGTISSAIDAQQTMEDMAKMEEKGGEDWTDERRVEYERRVTGKILTAAWRGSKFEIQSVLREVCDSVLNDKKVSLAKRLERAQALILIGDVFVKAERSPEEEGDYLVFEKLVADAALKKDKDDERRKKDKKSRDGSAGHDHHHHPHVHHHHHHHHHHAHDDSQGSHAADAASGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0L7</accession>
    <name>A0A367L0L7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Something about silencing protein 4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_7831</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000022">
        <property type="protein sequence ID" value="RCI07947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0L7"/>
    <dbReference type="OrthoDB" id="1938992at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033255">
        <property type="term" value="C:SAS acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038988">
        <property type="entry name" value="Sas4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029184">
        <property type="entry name" value="Sas4_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38422">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38422:SF1">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15460">
        <property type="entry name" value="SAS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Something about silencing protein 4" evidence="2">
        <location>
            <begin position="134"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="251"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI07947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="397" mass="44986" checksum="4DDAEFA5B745BE08" modified="2018-11-07" version="1">MAKPTADSHKGRPLSDDDDEDEKPRAKVRTSSQGRTLRSQEATRFKSELSAYFVDYDEVIGNEPKEQHLLNLETSVVVVDSAAREAQPHDDDDDDDDDDDYPVRDYSDALYTDIHDAQRIDFSFLESQQQTIDDPLPNTIYEPIHRRAQRVERSIRNTEKGRAQHEKGQIIRLLDGLQGHDWLRVMGVSGITETKKRAFEPAREHFIHGCQAILDKFRNWSEAEKKRKQKRTTGGKKRKSTADTPSAVRDSSSSSSSSSSPPSLAAEEDVVDGISDAPSSSPAEQLRQEAIMARSQRPVSTASSRRAPSPPPPPPPPPLVPDKPPSPRLFTSFFSKSYEREAAVSRNRRKGRKVLAWGHPIPDMAEVHFMLPEEYRDEDTLKVRARRKRRDNRSKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L155</accession>
    <name>A0A367L155_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_6334</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L155"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI08146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="43" mass="4869" checksum="BA463190D0D55FA7" modified="2018-11-07" version="1">MIQPYRIAGPSCLDAMMIAVRLIPRLNPSIHPVRHCSRQILCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L164</accession>
    <name>A0A367L164_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">L249_6265</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L164"/>
    <dbReference type="STRING" id="1330021.A0A367L164"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06609">
        <property type="entry name" value="STKc_MST3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000411">
        <property type="entry name" value="Probable Ste20-like kinase Don3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000488">
        <property type="entry name" value="Related to severin kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="18">
        <location>
            <begin position="11"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="318"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="546"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RCI08165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="616" mass="68324" checksum="CDC38259DBAD32CA" modified="2018-11-07" version="1">MAAAEGVADLYQVLEELGRGSFGIVYKGIDKLSGETVAIKHIDLESSEDDIEEIQAEIAVLSTCASPYVTQYKGSFLRGHKLWIVMEYLGGGSCLDLLKPANFSEAHIAIICRELLLGIQYLHSEGKIHRDIKAANVLLAESGRVKLADFGVAAQLTNIKSQRNTFVGTPFWMAPEVIQQDGYNYKADIWSLGITAMEMANGEPPLCHIHPMKVLFEIPKKPPPRLEGDFGRDFKDFVSQCLTKDCDRRPTAQELLKHRFIRSAGKIEALQELIARRQMWEADQNRSKHPIYYQETLQTMAPKDDEHEWVFETVRSTAPPSKVPSVRRRRPSSMLATEEGLRKLDLSEGPLGPSSPAVETVRKSTVRRRSSSVAQSMSRRSSRASVALRKPLQPDMSFGNSGSTMRLFRRVPSDGSARSVSPDGTIVDENMPPPMATPVEPYGKEAVLGRRLYTKAVEPTLAELHAQTSAMQKREALAKLSDAFAALDAVDPEGAYHLMSNLVTSISKDNKLDASLLRQPLSKAPGDGTPQGTVIVKDAGPAKLVLSSNNPHLKSHRRRQSESPAARGDWDKDMATLVQDKLPGREARAGMEHCKQLSDVLYQRWTDNLRIRWPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1C5</accession>
    <name>A0A367L1C5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Translocase of outer membrane 40 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_6307</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Channel-forming protein essential for import of protein precursors into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1C5"/>
    <dbReference type="STRING" id="1330021.A0A367L1C5"/>
    <dbReference type="OrthoDB" id="19656at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07305">
        <property type="entry name" value="Porin3_Tom40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.10:FF:000009">
        <property type="entry name" value="Mitochondrial import receptor subunit TOM40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037930">
        <property type="entry name" value="Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10802">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9" id="KW-0626">Porin</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00078731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI08216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="354" mass="38409" checksum="B464E90D153A176F" modified="2018-11-07" version="1">MTTSTVDSIRSLIFANPLAATIGDAINSFSDRRAKLGLSNPGSIETLTKEVQRDVMLNNLMFTGVRADLTKIFSMAPLFQVSHQFAMGGERINPYTFAAMYGTGKVFLQGNLDNEGSLSGRFNYRWTHKMVSKANVSVSPGGQDMAQFEHEYSGNDFTASLKALNPTFWEGGVTGICIGSYLQSLTPRLALGLETLWQRPALTQGPECAVSYCARYKANDWIATAQLQAAMGTFNTSYWRRLSDKVHAGVDLTLGIVPVAGGLMGGGLQKEGVTAVGVKYDFRMSTFRAQVDSKGKLSGLLEKRVAPQVMMTFAADVDHFTQQARLGLGVSIESMPEELQEQGEASAPPSNIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1D6</accession>
    <name>A0A367L1D6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5633</name>
        <name evidence="1" type="ORF">L249_6237</name>
    </gene>
    <organism evidence="1 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 3">BCC 54312</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-10" db="EMBL/GenBank/DDBJ databases">
            <title>A genome scan of diversifying selection in the zombie-ant fungus Ophiocordyceps unilateralis complex supports a role of enterotoxins in coevolution and host-specificity.</title>
            <authorList>
                <person name="Kobmoo N."/>
                <person name="Wichadakul D."/>
                <person name="Arnamnart N."/>
                <person name="Rodriguez De La Vega R.C."/>
                <person name="Luangsa-Ard J.-J."/>
                <person name="Giraud T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1D6"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI08250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="57" mass="6747" checksum="A292272175DFBACC" modified="2018-11-07" version="1">MLIILPSRYFSRYFKVPTCSTLTYLYKIGDLEEDLYVPYPAVSAVLRGVWVRIRPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1P0</accession>
    <name>A0A367L1P0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_8964</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1P0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI08359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="55" mass="5912" checksum="941705C73D8E07AF" modified="2018-11-07" version="1">MGIISISFSHLLNTNTSPASNSSLIASFRLSRDSSSSSLLRDHLSDSSTLYPLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L230</accession>
    <name>A0A367L230_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_8847</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L230"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI08476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="157" mass="17113" checksum="2D0CCB2AC60021B5" modified="2018-11-07" version="1">MGGTLCLLNWGGGPGYGDVAAVVIGCIDSARDGRGHAQMEREQELARELADKLGDVFKQPAGGTLGSAEEGRSKFSRAGWGGRDCRAFTRIGGEHTLRSSVMKCVQCRGGWIRTRYFGLCRLLLVLLSFVSGWPPSTHASAYEYYVKLTIRPDLTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2B1</accession>
    <name>A0A367L2B1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_4777</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2B1"/>
    <dbReference type="STRING" id="1330021.A0A367L2B1"/>
    <dbReference type="OrthoDB" id="546893at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050375">
        <property type="entry name" value="MFS_TsgA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702">
        <property type="entry name" value="L-FUCOSE-PROTON SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702:SF13">
        <property type="entry name" value="MONOSACCHARIDE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="15"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="481"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="513"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="589"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="639"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="741"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="766"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="801"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="829"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="4">
        <location>
            <begin position="34"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI08570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="936" mass="100519" checksum="F05FDBF51FCB0F7F" modified="2018-11-07" version="1">MDMAGSHEPPNRGPAVFAVTTATLVLATVFIVGRIVCRLRVVDRLSLDDKVMVLAWLLALFLSFTIDFAAVNGLGKHDDDISRSDFETLRRCEYGFSILYNPALMATKTSILIFYLRLAKNTQVVLRYASWATLVVVNLSGCVLTFMNIFQCSPIGAAWMADFDRESSCIPLLTEFICAAPVNIVTDLAILALPIPVLTGMRLPMRQKTILVMTFTVGAFVSVIDVVRIYYLQRAVAEVFTGPSTSPESRFGGQADFAWNASLSLMWSAVEVNVGMACACVPALKPLILKLLPSTLHDPGGGTWASTDTKRPSDLDATPFRKRSSTAAPALALESICLGDDGPSVSIVVAADPSSAPDAAFSAPDHPPICSPPSSLYFGFVNISKPRSLLRVGAAESLRYCTLVSVLFFLWGISYGLLRSLNNAVAGVNRMSSPKTLGLTSAYFGGGYFLGPLLVGGWILRRDEHHRSQRHGEVDADNVGGFKATFIVGLCIYGIGTIIFWPSAVTNSYGGFMLSNFVVGFGLSVLEVGANTFMVLCGPAEFGPTRLLLAQAVQGVGSVLSGLLADKVFFKNIANDDPRDSMTLINVQWTYLGITLLCVVLGLFFFYVPLPEVGDEELERAARRLPVDSTKRSVGGLQLRTVCLVLAVVAQCAYVAAQEGNNIFFRTLLASAPSPVSRRAAGGAGGHPSSLDEAARPLPGLSISIADFLLVGRGAFALSRFLLALLTHLSVGRRRLPQARTYLGISIGLCFASALVPVVRRPSSPNLLAVCTAVFFFAEGPIWPLIFAIGLQGQGSRTKRAATLITMGAAGGGVFPFVMYGIVAGGGGTVQTAYVVVVALQLAMMAYPLFLKLSGDARRLVDDVPRRAAGLEEDEEMPTDEVVARRHRIERKRMRRGESGLVRKASRAGLGAKLVLKLSHQPDVDHHEGDGRRARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2Y5</accession>
    <name>A0A367L2Y5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Protein transport protein BOS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L249_4658</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">SNARE required for protein transport between the ER and the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 12">Belongs to the BOS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2Y5"/>
    <dbReference type="STRING" id="1330021.A0A367L2Y5"/>
    <dbReference type="OrthoDB" id="158360at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15863">
        <property type="entry name" value="SNARE_GS27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000054">
        <property type="entry name" value="Protein transport protein BOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027027">
        <property type="entry name" value="GOSR2/Membrin/Bos1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF1">
        <property type="entry name" value="GOLGI SNAP RECEPTOR COMPLEX MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028865">
        <property type="entry name" value="Membrin-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="219"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="90"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00040957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR028865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCI08793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="240" mass="27278" checksum="F5019D520563DA27" modified="2018-11-07" version="1">MNVTFNSALRQSRALRSELVDLNAKGTPTPAEIGNVSASLATFSKTLDDYQNLSRQEIIQTKQEEAFERLKKFRLDLSDFRSQIDALKKARDEAQHQSNRNELLGRRPYNATPENPYANASVGSTPSVFQPRQPAAPLTTGSADEMREAHAFREQNFMASTNQALDEYIARGQAVLGDLGQQREMLKNTQKRLYNVANTLGVSGDTIRMVERRAREDKWIFFAGVIVFFLFCWLVLHYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L315</accession>
    <name>A0A367L315_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L315"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="86" mass="10334" checksum="3D7290E54A1162EE" modified="2018-11-07" version="1" fragment="single">HQHQHQHQHHQLQKYLRNERNSPSPITHHIHPCMFLSPLPYRSATADLQHFFFFPLPTSHRSATLQPIEWKENKIKKKVVSVTSYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L354</accession>
    <name>A0A367L354_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI08863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L354"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="203" mass="21989" checksum="E8DE81D62E1D1C2F" modified="2018-11-07" version="1">MEWNDGMGSAQIELNLALCMGLELCGGGGGGGGGDEVVHLTELKRARLAAIKGGDYQQRSGRDVCVNADLQNDGGCVGGKQGLNEWIRWRDGWMDGWMDLFLSDVSLYFCVGRILRRDVYVQVALPDSGRFRACGTDTKSANRELYTNGRSPIRTVAPRKAPPRPPPPPNLSRYPGTTYLDTVPTGCGPVGQQTSTVWGLELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3B8</accession>
    <name>A0A367L3B8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Kinesin-like protein unc-104</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L249_5116</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI08925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367L3B8"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047496">
        <property type="term" value="P:vesicle transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22705">
        <property type="entry name" value="FHA_KIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01365">
        <property type="entry name" value="KISc_KIF1A_KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.20:FF:000021">
        <property type="entry name" value="Kinesin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000047">
        <property type="entry name" value="Kinesin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2520">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022164">
        <property type="entry name" value="Kinesin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022140">
        <property type="entry name" value="Kinesin-like_KIF1-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032405">
        <property type="entry name" value="Kinesin_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117:SF10">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47117">
        <property type="entry name" value="STAR-RELATED LIPID TRANSFER PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12473">
        <property type="entry name" value="DUF3694"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12423">
        <property type="entry name" value="KIF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16183">
        <property type="entry name" value="Kinesin_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9 11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Kinesin motor" evidence="15">
        <location>
            <begin position="8"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="14">
        <location>
            <begin position="1540"/>
            <end position="1663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="609"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1089"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1205"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1406"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1604"/>
            <end position="1623"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="742"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="636"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1095"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1409"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1458"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1610"/>
            <end position="1619"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="97"/>
            <end position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCI08925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1674" mass="185429" checksum="FEC4A15223C86F5D" modified="2018-11-07" version="1">MPPAGGGNIKVVVRIDRGSKCIVSMKDNQTILTPPDSPAGRAAKETAAKTFAFDRSYWSFSKDDASYAGQSNLFGDLGKPLLDNAFQGYNNCIFAYGQTGSGKSYSMMGYGKEVGIIPNICQEMFRRIQAIQTLDHSTKCTVEVSYLEIYNERVRDLLNPSTKGNLKVREHPSTGPYVEDLAKLVVGSFQEIEHLMDEGNKARTVAATNMNETSSRSHAVFTLMLTQRKHDAETNMDMEKVAKISLVDLAGSERATSTGATGARLKEGAEINRSLSTLGRVIAALADLSTGKKKKNSGQVPYRDSVLTWLLKDSLGGNSMTAMIAAISPADINYDETLSTLRYADSAKRIKNHAVINEDANARMIRELKEELALLRSKLGGSGAASSPASGEVYADDTPLEQQMVTITGADGAVKKVSKADIAEQLSQSEKLLTDLNQTWEQKLQKTEEIHKEREAALEELGISIEKGFVGLHTPKKMPHLVNLSDDPLLAECLVYNLKPGTTTVGNGQNADHHHQAYIRLNGSRILHDHCAFENAPDGTVTVIPRENAPVMVNGKRIEEPIQLHSGYRVILGDFHIFRFNHPMEARAERAEVVGHSLLRQSLTASQISALDRSSPCHSPRLGHDRSFSKSSEPSIDYRPDSPRNGRDSDWSLARREAAGAILGTDQNLASLTDEELNALFEDVQRARAERVNVRDDGEDTESVTSYQLRDKYMSTGTIDNFSLDTALTMPSTPKHTEPETREEVADEVEEMRREKARMEAELQELKADLLKQLDLQREQYEEKMDKLDPLKRPRPNPRLSEKEAARARAAVRVWRGRRFVKMAESVLQEAATLKEAQIMSNELNESVVFQFTVVDIGHVLCSSYDMVLNGLTGEGEDGALEETAKPCIGIRVMDYRNSVVRLWSLEKLQDRLRQMRQMHQYLDQPEYAQHLSLDNAFAETCMPSYTLIGEVDVPLAAVFESRVHDLGLDVLSPHTSHTVGIVRLSLEPSHARAPSSRLKFNVVMRELLGFAEREGTEVHAQLFIPGVPEEEGITTTQMIRDFDEGPIRFESVHNMSVPLSAPRDVTLRVALFARVSSMHLDKLASWDDMRDSSGKGLLPSKSSSCASSSSSSSSSSSRLNESQFLTQEKHDLLSRVQMLELSEEGEYRPVEVTQTSELDTGTFQLHQGLQRRISISLSHSSGDALPWGGVTAVRVGKVRLVDSAGKTPDMGGEEPDVTLTTGTPPVFRDRSNGTRSVTLTAQWDSSLHNSLLLDRVTAERYRVQMTISWEMSSEKLAEPMRFAQKVCVQVLPRTFVRQQSMFSGLFQQVRFVRSSTGIFTLTLRPVPIKRVGDLWRASSRHDYVKGEEKLVRWAPRGVSLVTDFMAARKKRRRMAEIGAMQTRLLALGFRESGKKTGAESAAAAIVTRQDDDNSNHNKGVVDDDDADVLNDTPDTSQAPSINEEERDEGNEEGRGEEGEEEVEEEEEKTVKVLQADKDGSTRLLSKCVALWTKYPDPLSRILSPANTASPRNGIAPDLPPASTAPRLAATVVRVPKNPTLLRGGYLLVPSDVSSSSQRWVKRFVELRRPYLHIHSASDGDEVALVSLRNARVDSQPEVCGLLQGGGADTGEEEEEEEGGGSNARRFHTAVFAIYGTDNTWLFAARSERDKMDWIFRIDQTYLTPMNGGSPAGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3E0</accession>
    <name>A0A367L3E0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ML-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_5137</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transient receptor potential (TRP) ion channel family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI08945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3E0"/>
    <dbReference type="STRING" id="1330021.A0A367L3E0"/>
    <dbReference type="OrthoDB" id="5212126at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010308">
        <property type="entry name" value="TRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032800">
        <property type="entry name" value="TRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF2">
        <property type="entry name" value="FLAVIN CARRIER PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06011">
        <property type="entry name" value="TRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14558">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01320">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017000124" description="ML-like domain-containing protein" evidence="9">
        <location>
            <begin position="22"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="399"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="462"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="521"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="552"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="ML-like" evidence="10">
        <location>
            <begin position="23"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="647"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="651"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI08945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="666" mass="72622" checksum="879BCD4342DD886D" modified="2018-11-07" version="1">MGLLLRLLLLLVVTAPPVAMGERLLTSKSLNACQQESSFTASLFNVIYTPSNSTATVQMSVTSSIEGKVMFDVAISAYGYQFLRRTLDPCDMNLGGLCPMVAGKNTFTFNWKIDKSAAEQVPSIAYNIPDLDAAVRIYVNRTTANAGTPGESVACLEAAISNGKTVNLLGVKWATAIIAGLALLSSAIVNGLGHFNAAAHVAANSLSLFGYFQAQAMIGLTSVHLPPIVQAWTLNFQWSMGIIHTTVIRNICTWYQRATGGTPSDVFNALSTVSVQVAKRSLAGAAERLVKRGDIKVGTGAYIVYGIQRVAFQSKIESTNLFMTGLIFFYILIVTTILAVSAFKGICELCVRYKWTNKFLEFRNGWKTILKGILFRLALIAYPQMSILCLWEFTQVDSAAEVVLAVFVFLSLSLVLLWGASRLICIARRSVSLHKNPAYILYADPKVLNKWGFLYIQFRASAYYFIFPTLGYVLTKSMLIAFGQHSSRGIAQAVGLILIEAAALISASVIRPWMDKSTNSFNIAICSVNFLNAICLLIFTNVLGAPGLTVGIFSIVLFILNATFSLVLLIMLIVSTAVTFVRKDPDARYQIMADDRASFVKSMPQLTTTTIELDALAATARGDKYGVDSCFDDEAQALHRDGRRRFRGRDVSTSPSLYNRSGSSLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3Y4</accession>
    <name>A0A367L3Y4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein L22e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_1540</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3Y4"/>
    <dbReference type="STRING" id="1330021.A0A367L3Y4"/>
    <dbReference type="OrthoDB" id="10259820at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.210:FF:000002">
        <property type="entry name" value="60S ribosomal protein L22-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002671">
        <property type="entry name" value="Ribosomal_eL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038526">
        <property type="entry name" value="Ribosomal_eL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064:SF31">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL22A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01776">
        <property type="entry name" value="Ribosomal_L22e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI09131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="112" mass="12708" checksum="89153CFA71AD7765" modified="2018-11-07" version="1">MAVAFIINAQTPASDKILDVSLLEKFLQDRIKVEGRTNNLGDSVVIRQAGDGKVEVTAHNVPLSGRYLKYLTKKFLKKHQLRDWLRVVSTSRGVYELKFFNVVNDEADDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L409</accession>
    <name>A0A367L409_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_1505</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the complex I 24 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367L409"/>
    <dbReference type="OrthoDB" id="240546at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902494">
        <property type="term" value="C:catalytic complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098796">
        <property type="term" value="C:membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035658">
        <property type="term" value="C:Mon1-Ccz1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03064">
        <property type="entry name" value="TRX_Fd_NuoE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000022">
        <property type="entry name" value="NADH dehydrogenase flavoprotein 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1590:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1590">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013176">
        <property type="entry name" value="Ccz1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002023">
        <property type="entry name" value="NuoE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042128">
        <property type="entry name" value="NuoE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041921">
        <property type="entry name" value="NuoE_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01958">
        <property type="entry name" value="nuoE_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13056">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN CCZ1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13056:SF0">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN CCZ1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01257">
        <property type="entry name" value="2Fe-2S_thioredx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01099">
        <property type="entry name" value="COMPLEX1_24K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="10">
        <location>
            <begin position="45"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="568"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="658"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="875"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="966"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1061"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="570"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="660"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="879"/>
            <end position="902"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI09166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1339" mass="144930" checksum="EB1507C0D028B278" modified="2018-11-07" version="1">MTPKDLSKSRASLPSAHSTRSFWHREPSARLLGHRTTAELPAKADVVVVGSGISGAFAARELVKGGREVVVLEAREACWGATGRNGGHCQPGVWNSSPAVARFELATHDMLAELVGKEGIACDWHEVGGVHALLTAAELEAARTQIRRLEGQADLRDKAVLVEDREALRELRLGEAVVGAVVQKVAATCWPYKLVAAVLESLLEKDDGMMNLQTGTPVRGDLSAPDVVLATNGYTSYLVPGMADLIVPVQGQVCALRPPSDDAEELKHSHSWLPTASDDYLMQRPGSKGLLIFGGERCSVPGGRIGISHDDDVDPVIGARLRRAMAPAMRLRPRGAGPERDVLEAEAEWSGVMGYSRDGHPWVGAVPGRFLGVDDEEKESNPEEEDEAAGLWHRNTAENNPNVPFKFNEENEKIMAEILKRYPPQYKKAAVMPLLDLGQRQHGFTSISVMNEVARVLEMPPMRVYEVATFYTMYNRTPVGKFFVQACTTTPCQLGGCGSDVIVEAITSHLGIKQGQTTADGLFTFIEVECLGACVNAPMIQINDEYYEDLTPESVVELLRALKESAVASGGKGGGGGGQAAVKIPGPGPLSGRNSSIIPTRQIIAGGTMASSAASSSGAVVPARLGFLAIYNPSLGNTDETIDDQIVYYASVSTQAATPSRRRRRRGARARMRPTDGLGPEERNERLRQIGLAQGMASFSRGFADGAAVDAIDTEGARVVVHELETGWWILASIDLTKLPLPPRLLPTGTTDAAAERFEYSSREMKPASLLLSDLLRAHSIFLMHHGSSLSSLFVHCRRSKFMALLGRYWDLFLSTWNVLLHGNPARAMLGAINVAASGELGVGVGEEDRGSGEREVLEGLVGRTEGLVDLVVSKFGTDEQEEEEEEEKKEKEEGEEEEEEQQQWLGTGREPAADDGAIFLGTGALSRKSLRDVTHWMEDLYTWGEHAYGVIESPTSVRRRAKARAAQEASSNKPSAAVPAEQTDKTAAAASGGQKKDAAEDGRLDKMLSYMKLGYGSYWTLTGATASERSAAEGRPKRVSASEGSGHFLIGLTGEMEEAATAHGDDGDGSSGSEAEPNSRTVLRTVHVELERGPRPESTIVKDFVNPASEMTQSQLIGSMLSGHRSHDVNKADKLRVVVYVNRPFVLAFFFRLHTDSLAWDTMYRSLHHQLAPLRRPLLVSTRYRPSSSSSSSAPGGLYSLVWDAGSLTARAAVPNMPDQQLGLRADSAPPDDAFWSRADAASTHLQLLLLHAATRSLKGAVERTLKTSRGWWIVWTRLGDGGSEARDEDEEKRREGEDGGAKEIFLIRRASDHADAGLVQGIGVDTRRHVEELLSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4I9</accession>
    <name>A0A367L4I9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_3745</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000015">
        <property type="protein sequence ID" value="RCI09353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4I9"/>
    <dbReference type="STRING" id="1330021.A0A367L4I9"/>
    <dbReference type="OrthoDB" id="5409186at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016859771" evidence="2">
        <location>
            <begin position="19"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI09353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="265" mass="27086" checksum="53E467E2F29EA748" modified="2018-11-07" version="1">MHPSSTLVLLSALGLVASSQVFNMAVYSNRLSLARRDGSSAYQPEVAVCKEGMNSCEEACGAGFEQCPGAKGDEAHCVNRLRNESCCMGGHGQSCAAGFYCTVDNTGNNICCPEGQDLSACANEQKVAGQLQYATSTPPSSTPPTPPPPPPTTTPVPTPAAPTTTMMMASTTMMKNTTPLSTYQLVNTTTIASTIYLSPISSSASCTTPPFGALNSTVAKSTLASQAPFAAAPPQSPTGLTSRAVAHAPVGASMLVVVAALFALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L591</accession>
    <name>A0A367L591_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="5">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_4024</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="5">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="5"/>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L591"/>
    <dbReference type="STRING" id="1330021.A0A367L591"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="102"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="379"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="147"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="652"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="147"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="690"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="710"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="733"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI09589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="760" mass="83671" checksum="71BD59FA07C840B0" modified="2018-11-07" version="1">MFRLPLLLQRVKQQHKQRTQLARRFLYVLPGYHPERRHAGEVSKGLEAVDGEKTAPIKTQEAPVVGLEQLETRLHPELLKALRRRLDGEEVRGGTKEVVIEALLADDRPDAIVQARGGLRKMMTYLVPALQHVYASKDAAAAAASASSSSSSSSSSSPSSPSSSSSPSPQTTSTTTLTTTTTTTKKKKKKKHTNAQGGYISALVLVPTREIAWQISREARNIVGAEDKLLIYDAIGGVDKVRFEDALLRSSSGCFVVATPGRLLDLVNEEPVWRMLQSVDTLVIDEANHLFDAGFRDQLALISGRLAPKSDEQSRQTLIYSSNVPSTMETMAAPFFTSPNRLPVLTIIPKDEVPSYQSVPQHLLTVPDFASFLPVLLASLQAESERIGKESVKAIVFLPTGGFADLYANMINDLYRGILPVAACMSSRCKLGRRKKLLQEFIDARSGILVATDVVARGLTFPNVNYIFQVGLPHSLDSYYERLERFGGGAANNDNNNGKAIIILTKPELFFYERLINNKDKSYINLSKSPLPEEDRLRRVKEDLEPVMAYMGRAARFKLFLQLMSHYLSYNQEMGLSKDDVVSASYTFARDGLGAHNDHALDIDADLAEKMGIVNAPSLKLSRPRPKRRQQQEQPVVAVDKDNVQDVIETIQNDRSSSAFEPPFPPRIHKRAGMSWRDPQSWGEARNLPIFSQDNNRSSDGLDANQLPSGHGGVDGDGDGGGGHGGEHHHDCPSSSNHNDEPSSPETENQDTTHPPKIGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6G1</accession>
    <name>A0A367L6G1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6G1"/>
    <dbReference type="STRING" id="1330021.A0A367L6G1"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF5">
        <property type="entry name" value="BTB_POZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="23"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="236" mass="26208" checksum="E565EF8C13EF364D" modified="2018-11-07" version="1">MATANSNSALSALADLMKSEAFSDLTFTCNEHRFKVHKCVVYGQSPVIKAALSHDFEEGRTNVIPMDAFDPDTVRRLVQFFYTGDYRLTALPELEPPLIGSVDSLNMHIKVNSIGDYYGVTKLMSLANDKIKHLIQQEHKRRDVSAAVSGWVENLPAATELATSSSGDHELLAILAAEIAKNLSALTLSRDFRNLNVVSDLAFKVLEACVKEIQGFTMQINKMETQLRRRCGLCRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6Y0</accession>
    <name>A0A367L6Y0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8668</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6Y0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="118" mass="12776" checksum="E90D597119B6C2E2" modified="2018-11-07" version="1">MPEAPGSRDTRSAGSNMGTTVAREMGAVPRTANGEAKKHQAMRGCYEGRTAFDRFNIEARWKHNVGFRLPSEGAPPEASKQHMLGPQSEVCVFPYLASLAFVGRGSEPLIFNSRIAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7C2</accession>
    <name>A0A367L7C2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Spliceosomal protein DIB1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_4300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Essential role in pre-mRNA splicing. Also essential for entry into mitosis (G2/M progression) as well as for chromosome segregation during mitosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DIM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7C2"/>
    <dbReference type="STRING" id="1330021.A0A367L7C2"/>
    <dbReference type="OrthoDB" id="147752at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02954">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000004">
        <property type="entry name" value="Spliceosomal protein DIB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004123">
        <property type="entry name" value="Dim1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052:SF5">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEN 4A, 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02966">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017199">
        <property type="entry name" value="mRNA_splic_U5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01410">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="39"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR017199-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI10323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="143" mass="16856" checksum="77F481472DC72662" modified="2018-11-07" version="1">MGSVVVPHLQSGWHVDQAILSEEERLVVIRFGRDWDKDCMRQDEVLYKIADKVKGFAVIYVCDIDRVPDFNQMYELYDPCTIMFFFRNKHIMCDFGTGNNNKLNWVLEDKQELIDIIETIYRGAKKGRGLVVSPKDYSTRHRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7J8</accession>
    <name>A0A367L7J8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_8514</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7J8"/>
    <dbReference type="STRING" id="1330021.A0A367L7J8"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF232">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016993702" description="Cytochrome P450" evidence="7">
        <location>
            <begin position="21"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI10212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="489" mass="55900" checksum="038504473A11982B" modified="2018-11-07" version="1">MFWWCHLLVAQLTLVAVVLSRRYFSHLSHVPGPFFASFTRLWHAWHLLVGDMPAQLVRLHEEYGPFVRISHDEISVSHPQAVQQIFISPLHKAPWYKVAAVPDQRFQTPMSTLDPAEKRERSKHVASAYFLSNILRSEDEMDVLLGKFMRWMDRFADEQEPAPLDEFFSYFAYDLVGDMHFSQEFGYLDTGSDVNKSIAAFSVFSAYAVVAGYFPRLLALTVANRLVGSLGMLPMGHLYNTIVQSLDKRRSKVASRFDFVAHWLKEHDKNPSDFSMTDLYAVTVNSILGGSDTTATALQSLTYHIIRHPTAYRRIRDEVDEAQCRDAIVSFEDARKLPYLTACIKEALRVFSPLTLSLARVAGKQGVSIDGRVFRSGTKLSIHPWVEHLSKENWGEDASEFDPDRWLVPEVGAREKHWIPFGAGFNSCPGQHLVKVAIHKMAATLVRDYDIRLVDKTKAWKWKAGMTAAQYGWPVYIERRRTRRQPSCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7N2</accession>
    <name>A0A367L7N2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LYC1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7N2"/>
    <dbReference type="STRING" id="1330021.A0A367L7N2"/>
    <dbReference type="OrthoDB" id="2020070at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055100">
        <property type="entry name" value="GNAT_LYC1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053013">
        <property type="entry name" value="LAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815">
        <property type="entry name" value="LYSINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22998">
        <property type="entry name" value="GNAT_LYC1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LYC1 C-terminal" evidence="1">
        <location>
            <begin position="139"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="334" mass="37042" checksum="2E9DC3302D52F8E8" modified="2018-11-07" version="1">MATTTNPILVRPTDQEQVAIWAHGHAEWGAHLTPAQYEARERRLLATRLLRRGGLTPWMLTPSDGADGDRQRRALASCETLRKRALVRVGGGPVWLVRAEGVASVFVEPRLRGRGYAALMMRLLASRLGGEPDVAFSVLLRSKLASSPPPPSPPTTIRLALIPDLATLQWHFARQDFLAAHIDSLPRLPGEPVRGALYEDGDESRVWALWTVKSEPSRRQQAETNKLELLRLSYPESISQPQLQTAVEAVIGSAVSQSRRWLCTSIQVWNPDERLRPILDSMTHLQPELVDREDSSIASLLWLGGQDGCGGKGPGAEEEEVHVDWIANDKFGWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7Z3</accession>
    <name>A0A367L7Z3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ferrochelatase</fullName>
            <ecNumber evidence="12">4.98.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_4286</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the ferrous insertion into protoporphyrin IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>heme b + 2 H(+) = protoporphyrin IX + Fe(2+)</text>
            <dbReference type="Rhea" id="RHEA:22584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="4.98.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Porphyrin-containing compound metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the ferrochelatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.98.1.1" evidence="12"/>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7Z3"/>
    <dbReference type="STRING" id="1330021.A0A367L7Z3"/>
    <dbReference type="OrthoDB" id="1323at2759"/>
    <dbReference type="UniPathway" id="UPA00252">
        <property type="reaction ID" value="UER00325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00419">
        <property type="entry name" value="Ferrochelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03411">
        <property type="entry name" value="Ferrochelatase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1400:FF:000003">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1400">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00323">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019772">
        <property type="entry name" value="Ferrochelatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033644">
        <property type="entry name" value="Ferrochelatase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033659">
        <property type="entry name" value="Ferrochelatase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00109">
        <property type="entry name" value="hemH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108:SF1">
        <property type="entry name" value="FERROCHELATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53800">
        <property type="entry name" value="Chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00534">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 12" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI10539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="417" mass="45797" checksum="E9C3A0669B001BDC" modified="2018-11-07" version="1">MLIRQAGQKLVRASTMKTALLRLGGQTRNLATPVPPVTQDAAGSKGPTAMVFLNMGGPSTTDQVGPFLSRLFADGDLIPLGRLQSYLGPLISARRTPKIKQQYEEIGGGSPIRKWSEHQNAEMCKLLDKMSPETAPHKPYVAFRYADPLTEETYESLLQDGFGNGRGGHAVAFSQYPQYSCSTTGSSLNELWKWRQRLEGKGIASGANGTIKWSVIDRWFDARGLLEAVTQNVKAKLAEYPQERRNDVVLLFSAHSLPLSVVDKGDVYPAEVACTVQSVMKHSGLPNPFRLCWQSQVGPSRWLGPQTSSTVEQYIAQGKTDLVLIPIAFTSDHIETLYELDQEIIGTCGHIDTVKRAESLNGSPTFIEGLAEVAKKHLMRVSPCSTQMGLRCCACKSMRCLESKKFFAGPDTEMAIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAY1</accession>
    <name>A0A367LAY1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAY1"/>
    <dbReference type="STRING" id="1330021.A0A367LAY1"/>
    <dbReference type="OrthoDB" id="273010at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="512"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="599"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="682"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="603"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="635"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="689"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="699"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="725"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="840" mass="93431" checksum="BD8290B704052CF8" modified="2018-11-07" version="1">MHDTGYKPITVSRSAASQERPQCVFPASRERCSLSIANVSGHAARSPRPPALTSNPSPAEFSRFRDVERRDYDAIEFLLRKGRRQLQEYDSPALFPFAPRLTGAPPEAQTIRVSSRTSLSPCHDLSLQARYSFTNIKMATLASIPEASTSLPDTHPIRSLQRTASFERIRPRSRVLVLSRRPARVRNPARRAHVSNATRQATSYKPDAPPEASRRHPKVRDETLVNTQSAPQSSQLNDPTVESSLSSVDLDSFPLPPTHHFVKPSTRREGVVSPPRDRLLSNTRRCFGEVAVDVARGSKHSSVDSTLVDAISRAIAQQLRLCSAAKHADRDLIHPTKSNFSPSFARGSPPDRSDRRTSLDRFAADLRNYAETAGVTHNYTDPPGSGESLRTVSALMPFRPEFRAAGLAVTSKDQAQRTPGYFSKAYASLRPRQLFNKAPGNSNAHPSQVDGPAEVPSTRTGTEISFAPSQVDEWRYALIDEVPVRKKKRNMKPKRPKRSCFPCFRAKEKSAPDGDWAHFRPAPEKTAQESHRACEPRATRSVPPVLPGIRKAEPRPPRFDSVPRSPRYVSAARQISKTKDRNALSKSVAWPRARVMKMEHSASLPTKYQAQASEGRDDDRKRRLGSRQGALPPRSKVDPHSKTEPEKDHGHVSSALPSTWVRQDGPIPNLEEELEKTARLVRTAKASGRSKQQPTSSTRRQERPTPRYDPDHVGICCRSGRGMPSTATAPPNIPVRTSSVRGSISSDDNDEAITDRDVLRGLHVAASAACDQEVDAFVRDRTGLRIRRFLADLMTLESFGRPLPGEGSEERAWRRRAEMRMLKRQVRRSRELTGVAGGFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBB6</accession>
    <name>A0A367LBB6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7637</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBB6"/>
    <dbReference type="STRING" id="1330021.A0A367LBB6"/>
    <dbReference type="OrthoDB" id="28335at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42070">
        <property type="entry name" value="FILAMENT ASSOCIATED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G06630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42070:SF1">
        <property type="entry name" value="FILAMENT ASSOCIATED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G06630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="169" mass="17827" checksum="F58C4556E87127BD" modified="2018-11-07" version="1">MAGAKNAGPTSASAIRIRENQRRSRARRKEYVESMERRIQEYEKKGVEATLEMQQAARTVALENGRLRLMLAHMGAAASDVEAFLDQLRHRDAAHALSTVRLSADERSTSSSASPSSSSSSSSPPSSSSSSSSSSSSSSSSSSSSSTSTSTSLTTCGRVRPAVLTSFCP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBG1</accession>
    <name>A0A367LBG1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Presequence protease, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Pitrilysin metalloproteinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L249_7673</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Degrades mitochondrial transit peptides after their cleavage in the intermembrane space or in the matrix, and presequence peptides; clearance of these peptides is required to keep the presequence processing machinery running. Preferentially cleaves the N-terminal side of paired basic amino acid residues. Also degrades other unstructured peptides. May function as an ATP-dependent peptidase as opposed to a metalloendopeptidase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer and homodimer; homodimerization is induced by binding of the substrate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M16 family. PreP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBG1"/>
    <dbReference type="STRING" id="1330021.A0A367LBG1"/>
    <dbReference type="OrthoDB" id="10250783at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000013">
        <property type="entry name" value="Mitochondrial presequence protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000009">
        <property type="entry name" value="Presequence protease, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000011">
        <property type="entry name" value="Presequence protease, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013578">
        <property type="entry name" value="Peptidase_M16C_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055130">
        <property type="entry name" value="PreP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016">
        <property type="entry name" value="PRESEQUENCE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016:SF13">
        <property type="entry name" value="PRESEQUENCE PROTEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08367">
        <property type="entry name" value="M16C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22516">
        <property type="entry name" value="PreP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01264">
        <property type="entry name" value="M16C_associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16C associated" evidence="16">
        <location>
            <begin position="474"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00045897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCI11757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1009" mass="112625" checksum="53BD8805C3DAD653" modified="2018-11-07" version="1">MALNTARKFITDLSRFPAVGETLYGFTLVRAKQIPELELAALHLQHDKTGADYLHIARDDSNNVFSIGFKTNPPDATGVPHILEHTTLCGSKKYPIRDPFFKMLPRTLSNFMNAFTASDHTYYPFATTNAQDFKNLMSVYLDSTLHPLLKNSDFVQEGWRIGPDNPSADGSKMVFKGVVYNEMKGQMSDAGYLYYIRFHDHIFPDIKNSGGDPQKMTDLTYEQLTKFHAEHYHPSNAKIYTYGDIPLVAHLQELNARLVAFDRITPDGKIHEPLQLEEPQEVTLYGPLDPLVEPDRQYKSSVSWVTGDTSDIVESFSISLLSTLLMDGYGSPLYRGLIESGMGTDWSPNVGYDSSAKRGIFSIGLTGMREADVPKLKGRVEDILAQARDQGFDQSKIDGSLHQLELSLKHKTANFGFSMLNRLKPKWFNGTDPFASLAWNDTISAFKARLAQGGYLEGLVDKYLLNDRTLVFTMAPSPSYKEELVREEQARLASKMDELGGSAGGEETSRELFEEQEKALLTEQAKTETEDLSCLPTVLVEDIARVKRRIEADEDRLEGNETHWVETATNGLTYFRGIQKLTDLPDDLRELIPLFTDSIMRLGTKDMTMEQIEDLMKLKTGGLSVEYHSTPSPSRYQRATEGIIITGMALDKNVPVMYDLLHKLVLGTDFDGPEAPLRIRQLLQASADGVINDIASSGHRFAVGYADSGLTPNAWRRQQVAGLSQVKLVTRLAGRSESDGLEDVIDKLKRIQQLALASEGMRLAVTCGSESVESNRASLRQFLSGLPCRVSTGGREARGDDGAETDKVRQPTELTTARKTFFPLPYQVYYGGLSVATVSYRSSKSAALQILAQLLTHKHLHHEIREKGGAYGGGASFKALEGLFSMYSYRDPNPTRTLEVMRKAGRWAADRAWTTQDLDEAKISVFQSVDAPLAVNQVGISRFMSGIKQEMKDKRRLQLLDVTAEQVQEAAQKYLVENIEEGRERVAFLGEKQAWADDGWAVSEMNVKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBP7</accession>
    <name>A0A367LBP7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">40S ribosomal protein S22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_7175</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBP7"/>
    <dbReference type="STRING" id="1330021.A0A367LBP7"/>
    <dbReference type="OrthoDB" id="10250260at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.30:FF:000001">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047863">
        <property type="entry name" value="Ribosomal_uS8_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003115">
        <property type="entry name" value="PRK04034.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S15A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00053">
        <property type="entry name" value="RIBOSOMAL_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI11836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="14802" checksum="D2F1C194D4C3F5EE" modified="2018-11-07" version="1">MVRTSVLHDALNSINNAEKAGKRQVMIRPSSKVIVKFLQVMQRHGYIGEFEEVDDHRSGKIVVQLNGRLNKTGVISPRYNVRLADLEKWVVKLLPARQFGYVILTTSAGIMDHEEARRKHVAGKIIGFFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBT9</accession>
    <name>A0A367LBT9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial intermediate peptidase</fullName>
            <ecNumber evidence="4">3.4.24.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Octapeptidyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">L249_4219</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.</text>
            <dbReference type="EC" id="3.4.24.59"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase M3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.59" evidence="4"/>
    <dbReference type="EMBL" id="LKCN02000009">
        <property type="protein sequence ID" value="RCI11871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBT9"/>
    <dbReference type="STRING" id="1330021.A0A367LBT9"/>
    <dbReference type="OrthoDB" id="17530at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06457">
        <property type="entry name" value="M3A_MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033851">
        <property type="entry name" value="M3A_MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF79">
        <property type="entry name" value="MITOCHONDRIAL INTERMEDIATE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9 15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="17">
        <location>
            <begin position="280"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="516"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="523"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RCI11871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="799" mass="89062" checksum="5059C64799EB3ABE" modified="2018-11-07" version="1">MLRCWASRRLWVCANCFRRFSSTASAAASTQSPPSPPPDRAISSRHDDAVLRQLFDAPPSGTASTRFGLGKSQGLFKNRYLTCPEGFLVFARRNLEKATVIVRRVLAASTTSEYQALVRDLDRLSDLLCRVLDLSDFVRMTHPDARFQHAAAEAWSMVYQYMNQLNTMTGLNDQLGVALSRPDVTAVWSEEERTVAKLLKLDFMKSAVNLPKASRDRFVELSSRISDIGSSFVHCMQPEVKEVTLPSHRFYGLYPGLAATLKKRSLISVATTGSEAAAALQSVDDEETRRELFLAQRTASRRTISLLESMLELRAELSRLAGFESYGHMALKDRMMARSPAAVNEFLMALRRHNAPTVRHELVDLGRKKRQRLADETAELQAWDRDFYMEKIRAEMRCRSWPPAADDQLSSYFSVGTVMQGLSRLLDRLYGVRFVPREALPGETWHPDVKRLDVVSDHGHPVAVLYCDLFYRPQKSPNPAHFTVRCSREIGPQELSEAAADMNYTDGVSFDTAEQAANDGMETSSSSSSSSTSSTNGSLMQLPTIALVCDFAKNDNSGDPALLPHHSVETLFHEMGHAVHSILARTRFQNVSGTRCATDFAELPSTLMEHFASDPTVLSLFARHWKTDRPLRYDVVSDRIRVARRFQGLDTEHQILLALVDQAYHAKDVGPAFDSTAVFHRIHSSLSHGPLDPPSTRWQGFFGHLHGYGAGYYSYLFDRVLAERVWRVVFRAGADASAVSRHAGERLHLSLLRWGGARDPWRCLADALDDARLAAGDAESMALVGSWGIKDDGSSLAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBU8</accession>
    <name>A0A367LBU8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Helix-turn-helix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_4202</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000009">
        <property type="protein sequence ID" value="RCI11897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBU8"/>
    <dbReference type="STRING" id="1330021.A0A367LBU8"/>
    <dbReference type="OrthoDB" id="4085451at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054448">
        <property type="entry name" value="HTH_put_ascomycetes"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22943">
        <property type="entry name" value="HTH_68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helix-turn-helix" evidence="2">
        <location>
            <begin position="139"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI11897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="186" mass="19954" checksum="98130E611941F2D4" modified="2018-11-07" version="1">MGSYISRPASTTGRQSSKRKFPLRSHEIASLPSLAHQAPPVSRLAWPVPTSAAQDGSAGKTSCEDTIKHTTEFATRLRDIGIAQPVSISISRLEAATLRPPSSRDNATLSVLKARQAAQLRANDESGDVGLVQVRGRQFVHLGFILDALQMRSGGTSNSIIEERLGLRTGIMAKLGPRGLFDAAFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCN4</accession>
    <name>A0A367LCN4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_0906</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCN4"/>
    <dbReference type="STRING" id="1330021.A0A367LCN4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI12189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="128" mass="14941" checksum="D05A482447343978" modified="2018-11-07" version="1" fragment="single">KTRYKDIRTFSRKKGEFSAFLTNLKDKIRTDKATFRDEEDRIGFLFRSLEGKACKTLETRYDSIERPFSRLAEIIYLLTKTKDNSLSYEDFCGYVKDLPNDLPALAKYSLSILLPKTPLFNRQIDPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LD45</accession>
    <name>A0A367LD45_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_0217</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LD45"/>
    <dbReference type="OrthoDB" id="4927877at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI12358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="630" mass="70339" checksum="C864B7912D9424EB" modified="2018-11-07" version="1">MGLEVNMMVSYRPIGLELRFLKTLLSPLRSATAVSSSSPSSYTSFQMMKLIYFLGLAGPSLARVMLIPFRVDHQLLRFDGLHLSSYNTFLDDTALKEVMLVSVRGMRKRDVSSAGTPVVKQAVEDENRNEITLTEILSQGEPLDMDEHEKMVEEYLNAPEPFDPMRDSGLLNVTINGNAINLRTKRSASQPSHLIYENVECKKGSNGQVSTWFEIHTSYATYARSQHLGADVSVSAWGSGASVYASALDHSSFSENSITVVRVVEVDKQINADLDMQWNKDMIEKEPAKSDFGYASGGRLTVATTITVSTASSGNELQAGAEAVVSYWGVDASAKASAKKSMNEMSAKLTIKTRTFYQGDLARTIIPKADPSAMNENLSPAEAELDEAKRKVEQFLSEPCSHGYNYKTLMEEYSKIPGRPANFVIPDYRRAKGDAFGVTQKFERVVRKAELLKLKANFDEEQLEQLDRDVVDMQVAASDWLKETASKPGASRATSRTLIQRFQTEFHEKYDKDLARIHDQYDPVAKKYRSQKASNRTLVPPKNLWKCPLSRGRPTGEEEGTYCKLDNDGWYDPWAKMYWQGQGKEPKGGQEPIDLYLCPLISGAATGEMAGKLCKLDNGGFFDRKHFLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDX3</accession>
    <name>A0A367LDX3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_1024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDX3"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI12611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="61" mass="7124" checksum="4D4C8FEDE3D4E5D7" modified="2018-11-07" version="1" fragment="single">YFISRFLGPREQSTIAIKLKVPRVTYILAKLAYPIELELLLITSKRSLVIRIARKIGRHCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LE70</accession>
    <name>A0A367LE70_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_0850</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LE70"/>
    <dbReference type="STRING" id="1330021.A0A367LE70"/>
    <dbReference type="OrthoDB" id="4494341at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF12">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="12">
        <location>
            <begin position="309"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI12725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="605" mass="67466" checksum="E5716C1134EB474E" modified="2018-11-07" version="1">MDPSPSLQIRQADGTEDKVQPSSTIAPYSTALNGVNQPMNMLFRDIIWWTLGIVALAVLGIRILEILWAKLRQVSAMSQPRDKQAYWRVSQWNWMPPLKKHLIYAPLFGKRHNREFRLSSAVNVGTLPSRLHSLLLFLYVGSNTAYMIALNWSLENMFAVCAELRGRSGTLAVVNMVPLIILAGRNNPLIPLLKISFDTYNLLHRWMGRIVVTEVVVHTVAWAIPAVASSGWSAAFGKTVKSLFIGSGFWAGVAMVLLLLLSASPLRHAFYETFLNLHILLALAAFVGTWIHCSAGDLPALPWIVAVVGLWMADRLARLFRLVFANWSSRGFTDALVEALPGEVSRVTLYLPRYVRIQPGTHAYLRFWGVRPWESHPFSVAWVEYDAANSLPTSEKEPLTAVDRKTASTSVSFIIGAQTGMTRLLYDLASKSSSGIRIRAAMEGPYAGHHNLDSYGHVVLFAGSTGITHQISHVRHLLEGYNEGMVATRRLTLVWIIRTYETLEWVRPYMDMILRIPNRKDVLRIQVFVTRPDNPRDIVSASSTVKMFPGRPNIPLLLVKEVQDQIGAMSVSVCGPGGLADDVRGAVRAVQGDSVVDFIEESFTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LER1</accession>
    <name>A0A367LER1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_0768</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Vacuole membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ATG22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LER1"/>
    <dbReference type="STRING" id="1330021.A0A367LER1"/>
    <dbReference type="OrthoDB" id="42657at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF5">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="412"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="447"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="511"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="544"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="635"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="668"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="706"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="733"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="766"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI12907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="821" mass="90023" checksum="8E06DC1B93156411" modified="2018-11-07" version="1" fragment="single">MGSPTSHRLSPFPPPPPFDETHVMASIKPNQFFQASVSHQSPSQPSFTLFSVVIEPRHIGCLRCISSLSRTLFPLAVVSRYQGPLLLHHGQMETRQKSNVPPDHLVLQLSILPERRRLSPIPVGSLQYGEGAEPGTAARCLWQAAVDGMEDDRAGVFGCPQEALSQRRLEGLTVSFVLSLSLFCSAPEDIRGRKNQSHLYTAGCLVSIGIVVEKMGQLTADEDWESWPCIIIPTTAFAFPHHDGGIYLQLTLDRSRHLPRRSRCFLETEEAESLNFDGQAALTLHTTAKPQRPRPQRRVTFEGAGPQEGDKTSIYCRERQRSLSSGVVIYSPRAWYLYYTGANGLALFNLAPALLQSLLEKAASKSPGQQLDFGGRRRDVNSIVLLANGASFGAQAVLLLVIGAYADFGPGIARVLLLAFWSLVGYAVGFGWLAVADGQGDDGGGKWHVAVLLYAVGLVAYQLTLTYWTAALPGLARDSPSLQECRRRALPEDEMTRRYEMERSRISNLAFWWQSVGEVAMLAVVVAVMASLGRKNKVTNDRGLSALIAGTTAAWLLLSLPWFVLEQRRPGIAVAKDQTVVVAGLRRLVDAASHMVQLRQSLIYLAGYFLLGDSLNTTVTVVSTLQNQVVAFDPVTITGLLLAGIAAQAVGIASFWHVQRRFHLRAKTMFCIVCVAIVLVDGWGMAGNWTDRLGFRNVWELWLYQVLYGFFVCPWYSYSQVLISCVTPVGHEFLFFSVFNVVGKASSFVGPFISSAIIDAGRNSSAPFYFLFGLSLVSAVGLWAFLDLEESAREQAAFLARKQQVEGVVDSLSGSGSGSER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEX1</accession>
    <name>A0A367LEX1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_0749</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sphingosine N-acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEX1"/>
    <dbReference type="STRING" id="1330021.A0A367LEX1"/>
    <dbReference type="OrthoDB" id="537032at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050291">
        <property type="term" value="F:sphingosine N-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016439">
        <property type="entry name" value="Lag1/Lac1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560:SF0">
        <property type="entry name" value="LD18904P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12560">
        <property type="entry name" value="LONGEVITY ASSURANCE FACTOR 1 LAG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="277"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="9">
        <location>
            <begin position="142"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="431"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="447"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI12966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="464" mass="53510" checksum="4C106A9D1539B49F" modified="2018-11-07" version="1">MDDAHASSPPNSPLCLPPRNMNGPLYMQRSGSNVVLVRRLRRKDDGPWRQLARWFVENQIGLAFNLLALLFLAHSFIPKARAHTRRFFHLSYYDHDLNKYGVGFDDVYYIVFCIVLFTGLRAATMEYLLAPFARLQGLTKRRALTRFSEQAWLFIYYSIFWSIGMYIYSTSPYFLNLRELWIGWPVREIDGLSKAYILAQLAFWLQQMLVINIEDRRKDHWQMVTHHVITTGLIYSCYCYHHTRVGNLILVIMDVVDLFFPVAKCLKYTGHATLCDVAFGFFMLSWFVSRHVFYLMICWSLYAETPNVISAGCFSGRGSELSGPEPTPSGLYYMVEPLVNAYGRVCHDEAVKWLFLAALLFLQLITLIWFSMIVRVAAKVIRGDGAEDTRSDDDEDDIDEEDDEFVYEEARPLEEEVGVEALDLKGWERRTGVKRQASSSGVSLPGHSDRKELLGRIGCEKQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LF63</accession>
    <name>A0A367LF63_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_0073</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LF63"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI13051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="307" mass="34294" checksum="FB270663492B93AB" modified="2018-11-07" version="1">MPCNKHVAPLTRHLFLRLSSVRHRHRFRIWGGEGGYGDDLRMNRRIRALFWPFLGGGGVCMPSSHSYAERALPTTDSQRRLSGQFPHVAAWLFEHGWEKRGGRWLPRLFFPLSVSGKLGQLHGSPIVVFSLSHLLIILPFLRSSYVPPSFASCTASLTTLGERTYACPNLRDTTRSRKYVAAGRFCDAATGLDKEELLTYSNFSLFATLFVLLKLTSYCNQSSSPMALPSSLLSSTVYGVQAAGWQMACHLSLDVPFPVSFWLPNHGMANDSCRHGGEYEYVSVPRPTFCVVGQIKQFWGTSPPFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFK4</accession>
    <name>A0A367LFK4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">O-acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_1170</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Sterol O-acyltransferase that catalyzes the formation of stery esters.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFK4"/>
    <dbReference type="STRING" id="1330021.A0A367LFK4"/>
    <dbReference type="OrthoDB" id="10039049at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034737">
        <property type="term" value="F:ergosterol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008204">
        <property type="term" value="P:ergosterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014371">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408:SF9">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000439">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="191"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="410"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="541"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="38"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="259"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000439-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI13206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="559" mass="63483" checksum="085AEFC7B9B92FA7" modified="2018-11-07" version="1">MASTAHALPNGHHHHHHHHHHHVLRPRPKALQQLSRLVSSSELDETTTSCLTSGRSTPIPDNAPPSAKSLSSARRHARAEQRRRLFPTVEFASRVSHFDPASDYRDFHGFFNLFWIGLAIMGITTMLRNFKDTGYPLRIQIWSLFTVKLWHLAVADFLMVASTALSVFLHRWARNASGFWTWRRAGSVLQSLYQSVWLAFWILIPFWLEWTWTAQVFMLLHTMVLLMKMHSYAFYNGHLSEAEKRLCALDNPSAADRTPAYKYPSPDGTTVSAASSSSSSSSSSSPDPHPDAAAAAAAADDEKVDLLRESLARELTSPMGNVTYPRNLTWSNYLDYLLCPTLCYELEYPRVPSVNWTSLVSKIVATFGCIFLLTVTSEEFILPVLVDASRRLDASASPPSESLLILAESISWLLFPFMLTFLLVFLVIFEYVLGAFAEITRFADRHFYADWWNSTDWLEFSREWNIPVYSFLRRHVYGASKPHTGKMAATVITFLISAVGHEIVMACITKKIRGYGFVCMMLQLPIIMLQRTRCVRGRQTLNNVCFWCSMIIGLSMVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFL0</accession>
    <name>A0A367LFL0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA repair protein RAD50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">L249_0177</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SMC family. RAD50 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LFL0"/>
    <dbReference type="OrthoDB" id="18797at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001195">
        <property type="entry name" value="DNA repair protein rad50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004584">
        <property type="entry name" value="Rad50_eukaryotes"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00606">
        <property type="entry name" value="rad50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867">
        <property type="entry name" value="RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13558">
        <property type="entry name" value="SbcC_Walker_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Rad50/SbcC-type AAA" evidence="17">
        <location>
            <begin position="6"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="592"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="725"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="926"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1173"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="187"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="284"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="393"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="493"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="977"/>
            <end position="1113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RCI13210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1334" mass="151841" checksum="20C6094BB6D25FAA" modified="2018-11-07" version="1">MSRIDKLSISGVRSFSPALRETIQFNTPLTLIVGYNGSGKTTIIECLKYATTGELPPNSKGGAFIHDPKLRGEKEVLAQVKLQFHSINDREHIATRSLQLLVKKTTRSQKTLDCSLVVVNNGERTTTSTRQAQLDEMIPERLGVSPAILDAVIFCHQDESLWPLSEPAALKKRFDEIFEALKYTKAIDNLKVLRKKHVEELGKLKNDEAHHKVNKDRGERAEKRMTLLQAEIEGARDKCEALSAEMQETQDKIREKRDQANSFLQIVQNLSNKQEQLKYRQDAVNELRQTINELDEDDASLQESLAQYEQSMQRFRQESEKNKAQYNDLQRKLAQHRRDLATKLSEQGKHQSDKDKYVRQVASRATLIQVAAGSYSFRGYDGELTDDHVKSFGEKIQKLLDDKRRQLERLQRENSAELDKATAVITDLEGSKAARTQDRVSAKQRFGAIEKRMAVLKNDVTCIDIDQGAKAVLDSQLVDVDDALRRAQRDAEKSDWDRQLSLENDKLSQLESENEKLGRELVDCTRQASDRAQLDLRKKELADRKRKLETLKETWASKLSNVVGQAWEPDSLETIFQSVLVRQTKVVQDARKKRDQAREKQQKVEFRLRNAKESQEEKSQDAARCKEEVLAALRKVRDKAVIEDYQEEVESVEQRVEELKNDLSLFDALVDYYNKCKRFLESKRKCLLCERHFDDTQSASLERLSKKIDKQLDPRGKVDAEKDLKEETSQLESLRAARSSHDTYQRLSRELPAMSDECKKAEAEYDVLDRQLDELESTVSAEEEKLRDSEGLSKTVMGISQTVKDIKDAEAQVDRIASQQSSRGAMRSPDEIQEAQAKLAEQMRSLKARITKVGNDRQRMRDQLSSLELEKSELNNKIGRAAGQLEKKRDLEKQLEALREEHGHQREAMQGADRELEALEARMAEARTARDETLRRGRTREQSVAEERDGVAGTVSEIRMVDSEIESYLSRGGADELAANERAVAALEATMGKTEEEIDSVTVRANRLKQDMDNSDGKKKNMSDNLNYRRHLRTLEVLRTEIGELEARRADEDYDRHQAEARTLENRSNRLLAERGSAMGSMKTKDEELGRLLQEWEMDYKDAKQQYREAHVRAETTKAAIDDLARCGAAVDKAVMQFHATKMAEVNRIAGELWQSTYQGTDIDTILIRSDSESASSSSSSSSSATTAKASSSSTTSLSSAAAGRRSYNYRLCMVKQDTEMDMRGRCSAGQKVLASIIVRLALAESFGLNCGLIALDEPTTNLDADNIKSLAESLHAIIRARRGQRNLQLIVITHDEDFLRHMRCADFCDSFFRVRRDERQNSVIVRESITKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFM7</accession>
    <name>A0A367LFM7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="13">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">L249_0286</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="13">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with the U3 snoRNA and is associated with the 90S and 40S pre-ribosomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="13"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LFM7"/>
    <dbReference type="OrthoDB" id="360161at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17957">
        <property type="entry name" value="DEADc_DDX52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044764">
        <property type="entry name" value="DDX52/Rok1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013717">
        <property type="entry name" value="PIG-P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08510">
        <property type="entry name" value="PIG-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="186"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="811"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="1065"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="380"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="608"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="717"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="890"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1251"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="383"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="640"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="733"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="910"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1266"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1285"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="1295"/>
            <end position="1315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RCI13221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1315" mass="146345" checksum="B471B1C827EAD1D4" modified="2018-11-07" version="1">MKITLGKNRSYRLIPRAWPRSDKFLLAWLMPVELAILVPVLVIFGIAQPDLYRTAMWRIGFENKLNSNPNMILYAFANHRPLPDVPFIWSSTWVSVDARLTSFNVAISIVSLFFLLIKLIGYIMRTWYPVFAIFANIALVVLYAVSVYGQVGPDYADARYQASAAWYFRQGCGLAKQYDKYQACQIAQASLAITLLLLRFSTVYLINLAIALHATWPNRENDVSNEDDEDVATLDSTERGTWEMHSMKAPASTPYTPRTQAFYTLDRQLPLRQPDYGQAWVHDMIWTYWSGALSKALGIYEYIVSGNDERRKGGHTHKSKCRRTAPASLVIMSASSEEKDEYLSDNQSSDSSGHEWPARPLSQTFFAPPFYGRPPTPLPPSPSLTSLLRPSRPTTPDASDDENMAPVPRASPQVPTYEYYGFVLYLFSSMSFLLWLLWSYLPAPFLHGLGIYYYPNRWWALAIPAFLTMTLCYIYVALASYNTEMMTLPMASVETVVDGAGKLAVIDAKGRLRGSNKRERKCDHNGRLRCRHGYSSSRRMRGPFRRRARGGGLNEWLFDFHHHRLNVAGYINPTASTLPIPPAILSAHFQDQVKTSNQTAMDILKLLSRGTKRPSQAKRAGSDASIKLPSAGTKTNPQLFHDHAHGQKRKRDEDEPLRKHAVEDLPVVDFFAPKVEASHFTTYKAQQAPSPAAQPSERLSVDACRELLRSHRLKLTVMTEPDGRQASKRKEKASKGKEIENKNKSSGVGAKPDKRQLFPQPLRSFGELRSTYGISRRVSENLAVQGYRVPTEVQLGALPVLLRPDIAMIDERDLSEGVNFLAVAPTGSGKTVSFLIPAINSIMRRRALQGLQGIHELEAVIVAPTRELVFQIVNEGRKLTQGTGLRVTGMRKGTRVVSDQSGVTKLGSGAEEDDDDDDESQSEDDKPAVEAPAPVAKADILVTTPLLLFRSLTSETADGQCKTLPTVRELVLDEADVLLDALFREQTLGIWTACRNPSMRVSCWSATMGSNIESLVVDKLKEWSETRDIRLKPLVRLVVGLRDTAVPNIAHRLIYTASETGKLMALRQLLHPAPGDDAGPPLRPPFLVFTQTIDRASALREELKYDIPLEAGGPSRIEALHSELSDSARAAIMRKFRAGDIWVLITTDVLARGVDFAGVNGVVNYDVPGSSAAYVHRAGRTGRAGREGGVAVTLYTKDDIPFVKTVANAIAISEKQAGKTGSQAGVQKWLLDALPNVARADRKKLKYRGVDSRRSGTGAKITSKSGYDRRREHNRMGAIAGSKRRISEARRDVDEAQVDEEGEEEEEEEWTGFGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFY7</accession>
    <name>A0A367LFY7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyl transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_1202</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFY7"/>
    <dbReference type="STRING" id="1330021.A0A367LFY7"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46830:SF2">
        <property type="entry name" value="ALPHA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46830">
        <property type="entry name" value="TRANSFERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI13336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="39602" checksum="564BEFDD4F8EEAEF" modified="2018-11-07" version="1">MRPTKRALRPFFLIGFITIIVLSPLVYYHAYRENNFNIEVHPTPLVLPAQDIPDRAHFVYVVEDEEADLVLTFSQALSVFAARYHWHPREMFFHTNAADATVLRARQGRAGKWSKMILDVPEMTVVRVRLPMQAANGVPIRYMEHKSDFVRVQAVRDFGGVYLDFDAHVLRDIRPLLRMGFRAVGGRQVDGLVISGTFMASKGAKLVSRWYEEMHRVYDGAWITHSNKLITSIGQSLVPEAGQMLILDRAALAPGDWSKAQCTNLWQTHDPAAAPEATWLHDYSDTWILHAFSPHRFQWPIKGYSSITPRYVLANQSNFARAVMPVARYMLEQGLVEDVHDDTERGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LG13</accession>
    <name>A0A367LG13_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LG13"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="114" mass="12298" checksum="923CB4A5B7841243" modified="2018-11-07" version="1">MLVDYQGRRDHSAPNRPSIYLIYPTSSTLPEVGPSAATAAAAAAAAVAPGNQPTERQQSVHAAQSPSKREEQNNTHPFSFLQRSATFPPPPPPDWRRIPVLPRPSTITLPPSLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LG17</accession>
    <name>A0A367LG17_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LG17"/>
    <dbReference type="STRING" id="1330021.A0A367LG17"/>
    <dbReference type="OrthoDB" id="21292at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033328">
        <property type="term" value="F:peroxisome membrane targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045046">
        <property type="term" value="P:protein import into peroxisome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.900">
        <property type="entry name" value="Pex19, mPTS binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006708">
        <property type="entry name" value="Pex19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038322">
        <property type="entry name" value="Pex19_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12774">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12774:SF2">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04614">
        <property type="entry name" value="Pex19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="299" mass="32653" checksum="139D31D4258FCEBC" modified="2018-11-07" version="1">MESTSKEDAEAPSNASVAVDDVPDPDEDDLDDLDDMLGEFSTVKLDSSKATAASTEAPSPKKAEDELSEDEFAKQLQAGMADLLGGLENSPEMQEQLEDMFRQMAGDPAIAQDATASSSTRSTADTGTDASFQDTIRRTMERMQTSGDQATAAAASDGTDDFMSEMLRQLSSGELNADGGDEDLSKMLMGMMEQLTNKEILYEPMKELNSKFPEWFDKNRESTPAEDLKRYEEQQTLVKDIVAKFEESSYSDSNPADREYIVDKMQKMQAAGTPPSDLVGDMASAQEAFNVADDQCNPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LG48</accession>
    <name>A0A367LG48_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_1221</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LG48"/>
    <dbReference type="STRING" id="1330021.A0A367LG48"/>
    <dbReference type="OrthoDB" id="784962at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050935">
        <property type="entry name" value="Bromo_chromatin_reader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027353">
        <property type="entry name" value="NET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038336">
        <property type="entry name" value="NET_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880:SF225">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN BET-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880">
        <property type="entry name" value="FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17035">
        <property type="entry name" value="BET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51525">
        <property type="entry name" value="NET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="497"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="779"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="domain" description="NET" evidence="5">
        <location>
            <begin position="1014"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="593"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="885"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="967"/>
            <end position="1022"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1093"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="68"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="200"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="272"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="615"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="633"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="893"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="973"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="993"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1169"/>
            <end position="1178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI13389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1178" mass="125646" checksum="474F64D6CFE3CA1A" modified="2018-11-07" version="1">MTSPGPKSPGPDAQPPEPVHGKESHSKMNGHPPPDEPALEPKPKSAEEPPTKKMPSEGETALSPKGDQPSEKPADKATDDQAAKATDKAADEQADNETEKPVDGSTEKPVDGSTEKTVEKPADKPAGEKDEKATDKAADEQADKATEKPVDGLTEKPSDEPADEQADKAKQADKAAEKPVDASTEKSADKPTVTPTGEESADKPTPDEKSTSIDDTATEAGVTETDKPKQETLQPETTFTPAAKDDDAKSSADQKEKSEPVEANEPGSTSPDAKESVSKSSEKPLEAAAEDDVSMIDCPPEVADHDSAAPVADEQTAAPTSSSGNNPEHDMVMTDMPCEEEAAQPPKPSVSHDAAPDAAKAPVDTEVDLGSAGLSQLAIESAGKESSRDPPPADDALMVDAPSAKIARERDEDHAEEPAPKRARTEPTEDEAMQKTPADAKGDAADETAAAPATVDAPILDELFPTRLIKWTDATVNASLITSFQRQEIRKHLTKLRKNKLGSPFKDSVEKLWPDLWNSYQLKIDRPMDLGQLERSLRVGRDDSGNAMQSFADFKKNLALIFENSLAYNGAAHHVTEASANVVRTVWEEAMRLPSEEPARPKPPPKTKPVRESRAAATSAAASAEAAAHHRPSAAPTTTTTAPAGGDATATKPAEAALPTPTTAPPAEAAPQPPTQASAVVGKWQPGGSGGGGHRRSLTAADIDRPKRKVRAPKPKDIDYSTKPSRKKMKPELQFCDEVLTELMHSRNHRQNSTKPSRKKMKPELQFCDEVLTELMHSRNHRQNSWFMEPVDAEGLNIPTYYATIKKPMDLGKVRRMLSGGEIANAKDFDKNVRLIFDNCYKFNGPPSEKHPVSALARELEELYTEQMDKKDEWLSKHAAKANAAAASASNASDDEDGDDDDDDDGGGGGADAVVDSVEVGELRAKLDEETRKLNELILGGNQSLIKIHKGIVDMVQDALMEAVQKAREAKAKRGKSKKSAKGGKVNKTPGGRKSGGGGGGGGGGGSSQAKKSGGSKKATKRNLTAAEMDQVANAINDLEHPHLQRAIDIIKKDTGQNENTDGELELDIEQLSNDAMLKLWDLCKKALPAFGKDSTVAPDESAEVNRGAGAKQAPKTAATKRKNKPMSAQEQDARIAQLKEVSKLYRPPGQEPAEVAKVTQAPTPMGDSSEDSDSEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LG56</accession>
    <name>A0A367LG56_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_5584</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plant acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LG56"/>
    <dbReference type="STRING" id="1330021.A0A367LG56"/>
    <dbReference type="OrthoDB" id="21502at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051283">
        <property type="entry name" value="Sec_Metabolite_Acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896:SF69">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016678284" evidence="5">
        <location>
            <begin position="16"/>
            <end position="598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI13405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="598" mass="65785" checksum="F79F153BD09F6E48" modified="2018-11-07" version="1">MKLHLAILATRGAVAAVFNQLCLELCSNAKMFDCHTILISPGDCENLDSVPRSGRLRSRGFCLVYQQEGCVGDSAVIDWVGFSAMFPFEREKEKKDAMDDDSIIYAYPLHPLDRLSGTRNIFVSWVMRFNDVLDADKLHQSLSRLLELGDWRKLGGRIRRGKDGKLKIHSPAQFGSLLPAIAFGHDDLSDSSIEQHRVASLLPKPTRDPFIGDSSFNDVFRPLSGLAMMPQTLDDIIRTEAPPLSLHVSSFSDATVVALSYPHVLTDAFGLRSLLSSWSLVLAGRETQVPALRGATTDLLREAVRRSEAGEAPGGVRPETHVLESIRLGKLAKTKMLLRLAAERMKKPEPQQRVIFLPEALVTRLQQTTSSISTGDILVAWLVRGIATAAVSPKPPPPVTLISAANARFHLPSAVKPDEALAQNMVFMTHTPLTREQTAGPLEGIARAFRSQIQAQTTEPQLLGLLRSTYRALDAGQEPLDVYGETSAVPMLVNDLTDVDVYGAVDFAPAVVKRGDTTTWADNPPGTVVYCHLQSRLVNDQKMANPFDNRFALLLGQAFEAIDVCRDIKIHPPARLMQLYQPVEASGEILDLECLEQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LG83</accession>
    <name>A0A367LG83_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LG83"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI13444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="77" mass="8543" checksum="DACD243120A05B4F" modified="2018-11-07" version="1">MLTRRLINRTLIYRKFDCLDRPPFLGSLTYPTFLPSYGPYGPYGPAVTYSLCDVRRPRAGCSRPGVTVSGAPAKIGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGJ1</accession>
    <name>A0A367LGJ1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5603</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGJ1"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI13553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="100" mass="11227" checksum="3D2AD66097CF6A05" modified="2018-11-07" version="1" fragment="single">LLSPAPAPYLVLPAAGGYLRVRLITEDKENNFHKSFFLFRLSSLSSVLASYPSLSPRPKRPTKPADPRYRLFPGTIVVGKETVYLKVPPWAMPSCPWLNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGR1</accession>
    <name>A0A367LGR1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dynamin GTPase</fullName>
            <ecNumber evidence="3">3.6.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">L249_5487</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGR1"/>
    <dbReference type="STRING" id="1330021.A0A367LGR1"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000741">
        <property type="entry name" value="Putative mitochondrial dynamin GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056495">
        <property type="entry name" value="LIS_MGM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF212">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24550">
        <property type="entry name" value="LIS_MGM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13 17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="20">
        <location>
            <begin position="241"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="19">
        <location>
            <begin position="807"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="896"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="896"/>
            <end position="920"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RCI13600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="929" mass="102996" checksum="3C62A0C188C0A275" modified="2018-11-07" version="1">MMPIASRGRALTASQHLTARRVPVVAGRHVHRFLNRGTLQADASARAARRRLWFRNNAFHNAVIARNASFASFLPRLVVKFARIPAMFGGLAIGAFAWVQYQATQASNYAIEVFNTAKDTLSSTASTLLSGAQQVSDQTRQGWDNTKEQIEIPLWLRKVLRIDDDSGPGRSSGPGKDGGPKQSRAGAAGVVGASAAAFGSDKSTEDDSRDFEIARDDQMMVLTKKMIEIRSILQQVGQSSSLALPSIVVIGSQSSGKSSVLEAIVGHEFLPKGNNMVTRRPIELTLINTPESQEEYGEFPNLGLRQIKDFSSIQRTLTELNLAVSATECASDDPIHLSIYSPSVPDLSLIDLPGYIQVVGQDQPLQLKQKISELCDKYIQPPNVILAISAADVDLANSAALRASKRVDPRGERTIGVVTKMDLVDPAKGAAILNGNQYPLRLGYVGVVSKAPQSPGLFKMGSSNSLSTITKNENNFFSAYPLEFGPESGVSVGTTTLRKKLMQVLEQTMSSSLQSTSDAIKQELEEATYEFKVQYNDRPLSAESYLAESLDSFKHAFKQFTEHFGRPEMRELLKSELDQKVLDLLAARYWNKPIPDLAAVQQEPDQIADLPKADPSSLYWRRQLDASVSALTKLGVGRLATTVVASSLQSHVEKLLNSSNFATHPFAKEAILEAASSILKERFYGTSDQVENCIKPFKFEIDVEEREWTQGRQHVGNVLKKELQDCEAALTNLESSVGGRKKLNEVMSFVDKARKGDIIIEGDGRSGAGGFSAALLNRGREAVFLRDRSDIVRMRLMAVKSKQCASVEKKYYCPEVFLDAVASKLASTAVLFLNVELLSEFYYNFPRELDLRLGRHLSHDEVERFAKEDAKIRRHLDLIRRKELLELVLQKMESMKQLEGREREREKAGWRRDSEKDHGRWGLFRGPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGX7</accession>
    <name>A0A367LGX7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CWH43-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_5457</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGX7"/>
    <dbReference type="STRING" id="1330021.A0A367LGX7"/>
    <dbReference type="OrthoDB" id="10032492at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050911">
        <property type="entry name" value="DRAM/TMEM150_Autophagy_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324:SF2">
        <property type="entry name" value="EG:22E5.9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324">
        <property type="entry name" value="FASTING-INDUCIBLE INTEGRAL MEMBRANE PROTEIN TM6P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="6">
        <location>
            <begin position="44"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI13670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="295" mass="33234" checksum="C56168BC3C0DDDE0" modified="2018-11-07" version="1">MGKSLSPPRKWGERFVVRRASDQTSTQPSLTSAPARSRSRYISYWMLPLFSSLVWLGMLLGMLLYWTIVDDSRHLPSMSVNANVSFISDIGAFRLKPLFIAGSTVTAVTLNLAFVAERWLRHNGRLLPNTSLTEKLLSALTIFFAVLGAIGLICLTIFDTWMHHEKHNGFLVIFIGGYLASSVSTCWEYQRLGIKNRQHPLLRISFWVKLAFFSTELVLVILFGSLSAAHQQDAAAVFEWIVAFIFTFYILSFVIDLWPAVHTKHPANRFEKPLSISSGLSSRSDLEQSDAANYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LH18</accession>
    <name>A0A367LH18_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_8158</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LH18"/>
    <dbReference type="STRING" id="1330021.A0A367LH18"/>
    <dbReference type="OrthoDB" id="10069473at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099122">
        <property type="term" value="F:RNA polymerase II C-terminal domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17003">
        <property type="entry name" value="CID_Rtt103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000030">
        <property type="entry name" value="DUF618 domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047883">
        <property type="entry name" value="Rtt103-like_CID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12460:SF0">
        <property type="entry name" value="CID DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12460">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="3">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="277"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="244"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="363"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="377"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI13718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="387" mass="42046" checksum="7FE24D36B730C2EA" modified="2018-11-07" version="1">MAYNDDSVLARLSSLNESHDSIATAAQWIMFHRRHADRTVQLWMQRLKESSSTRRLSLVYLANEVVQQSRIRHKEDFVIAFSPVVAEATSIAYKGAPTEIQAKLKRVVDVWKDRSIFEAPIQGAIEARLEELDKARGTVKPAFGGSPFGGSSLPSEFTPLVSSHQKVAKLSAPLQTTITSANQEYDKYTSPNTIVPSAPVYAARLNGLLKTLANAESAVAECVKAREGLVSGLEKMLESNRGALESDKSTAAELLKRKEEIEEKKQEVEMAIMRALGPADGNGSQEEGGSASPPPEPDRPEMEALTPPAIDDDAMETVVVPSPPEAPSDEVLKAETPPDVAPALQSVTIATNGSNKRRRIDSGDEFPDLDGDGEIDAEVKEMLKDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LH25</accession>
    <name>A0A367LH25_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8264</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LH25"/>
    <dbReference type="STRING" id="1330021.A0A367LH25"/>
    <dbReference type="OrthoDB" id="8300194at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="46"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="271" mass="31187" checksum="1F21F1691B7A8111" modified="2018-11-07" version="1">MANEQPCAACGWTQQRRESCRYHSHIKLFYEVSDRGVWAIARNTRFIQHHTTVPVPETVQEWTENGRYFLVTKRVPGTTLHEAWPAMSESEKNSIAKQTASYLCQLRKLHSSSMESLGAEPVYSAFLFRNGYGRPHCPFCSDHQLWKGMAEALSKVPENARRHLQQRMPVAKPYTFTHGDLSTRNIIVDNGKVTGIIDWEGSGFFPVWWEFVAAGISEDDDDRAWKALLRQWMDDCTEAQDFWLDYYALSRYPNLDSRGMGLIGDLNGRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LH62</accession>
    <name>A0A367LH62_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_8315</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LH62"/>
    <dbReference type="OrthoDB" id="5242881at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI13751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="63" mass="7163" checksum="903B8FA16300A554" modified="2018-11-07" version="1">MPLGPLRPDDSSRRLYPTRNFKNAPIALQEYYNYYLAAAAADKLYNDDDDDNRITITAAAPRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHG3</accession>
    <name>A0A367LHG3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_8063</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHG3"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI13839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="45" mass="5155" checksum="9F9085C1E109B150" modified="2018-11-07" version="1" fragment="single">MTETRRKEADSPALQGYWKSRHSILLIQEAGEITLPDDTYETACE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHW5</accession>
    <name>A0A367LHW5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_7995</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI14000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHW5"/>
    <dbReference type="STRING" id="1330021.A0A367LHW5"/>
    <dbReference type="OrthoDB" id="412109at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043124">
        <property type="term" value="P:negative regulation of canonical NF-kappaB signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038753">
        <property type="entry name" value="NFKBIL1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15263">
        <property type="entry name" value="I-KAPPA-B-LIKE PROTEIN IKBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15263:SF1">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="186"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="65"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI14000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="42038" checksum="88FA8A45B2AF8FD8" modified="2018-11-07" version="1">MGDRPSLSSSPKSRHTRSWMNTHRARRQSCDIPIQSCERPLPTEARPPMAAKPVAETEGDPLRPRATRIRLKKHRTSAQPTSGSHQRRHGHRRRHHHHHHHHHHHSRSPTPEIPGPPPLDAETAFRESLFDAMADDEAAAYWEGVYGQPIHVYSNEKVGPQGELERMTDDEYAAYVRQKMYEKTHAGMLEEKARREERKKQEEREARERRRQRKESARQSRKLEEEAERRSRKLQEDVERSIRHGEARRQRKIWTDYVDAWATWNGDVAKLPWPVEGSRRRGLNEADVRAFFVNGLDLESIGAKNFVAGLKEERVRWHPDKVQQRLGGRVDSDVMKNVTAVFQIIDRIWGEMRKKLTDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHX3</accession>
    <name>A0A367LHX3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI14025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHX3"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="169" mass="19835" checksum="B01208F2EDC0A8ED" modified="2018-11-07" version="1">MQYSCPRGSHVESEMGLEQGEHHEAMSRRGGKRREEKRSERGPYAAVTCANFWPLSLWPMTVHIYDPTTANECHARTQRCVFRRRPDTCIGTCMNPWTESFFIHFRPSATPPVKEVRQHFRSLLGEYIQDIIYVEAPDKKSLPPLYVQWYIYDIYNTCYGMHIGQLLFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJB4</accession>
    <name>A0A367LJB4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6853</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJB4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016925306" evidence="1">
        <location>
            <begin position="26"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="162" mass="18204" checksum="E158EE0A483A87D7" modified="2018-11-07" version="1" fragment="single">RTLYHAPFFSSLPSLLFLLFRFPRAVPPSSPHSSLQKHLALRNWPTDECKTAPSSGPLHLDDPMTRHPGLRAAWTGRPVSTSQTPLFSHPLGTLPRKAATRRKLFACHLRLSFVSSSSHLNLSLSLPAIDRCNADIAFPYNVDELNSRNLMQNPVRPLTIYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJP9</accession>
    <name>A0A367LJP9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Asparaginase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_6095</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJP9"/>
    <dbReference type="STRING" id="1330021.A0A367LJP9"/>
    <dbReference type="OrthoDB" id="77601at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04514">
        <property type="entry name" value="Taspase1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.30:FF:000007">
        <property type="entry name" value="Similar to threonine aspartase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.30">
        <property type="entry name" value="(Glycosyl)asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000246">
        <property type="entry name" value="Peptidase_T2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037464">
        <property type="entry name" value="Taspase1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10188:SF8">
        <property type="entry name" value="THREONINE ASPARTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01112">
        <property type="entry name" value="Asparaginase_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="322"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="286"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="397"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="2">
        <location>
            <begin position="396"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600246-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI14492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="580" mass="61184" checksum="FA023B92F0921D0D" modified="2018-11-07" version="1">MSPCSHNAATDPMMARIQCGTDGVLDRVLHLNQKQNSVPAIFIHAGAGFHSRQNETVHLKACVSAAEMGMRFLKAGATSTEAVEAALRILEDKEITNAGYGSNLSMDGTVECDATIVDHLGRSGACGAVPTYPRYQQLAPESSPCAPQALVGEGARAFAEEHGMATFANDYLVSTNSRDRFYRWQEDLLRAEGGGKDVGLGPHLAPSKAATCIPCQYETAPTLDPLKPFPRQHAAAILTGTWNEGQTDSPYAGTPVLESTESAMIPAHVTTTPMMTFAAAARSSLHLPTSQRSPAPSSSAGKDKAQGTKSLASEVKKMLEADEKRKQVHSTTPSSPTAIGRFDAGEAKSFGTHIDANASRRFKRPAEPTTPDGALRGPSPKRVSCWEMDEGDVVTDTIGAIAIDGRGLIAAGSSSGGIGMKHRGRLGPAAIVGVGTAVVPCAAEDEGGLTVAAVTSGTGEHMATTMASQKCAERMYQGTRRGPLGFDITDDDEDDIMESFIANDFMNHPGVKHCHASGAIGVMVVKKHRTGYYLYFAHNTDSFALASMGGLDKKPHCTMSRLPEGSKIAKGGRKIRTTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJV2</accession>
    <name>A0A367LJV2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6434</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJV2"/>
    <dbReference type="STRING" id="1330021.A0A367LJV2"/>
    <dbReference type="OrthoDB" id="4140442at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="299" mass="32983" checksum="0AE8F833DAE91387" modified="2018-11-07" version="1">MACFLRGLGSPCLVWSQPAMMLMHGPATRTGRFFASSIGRARKQVQADTLALAQAMQTGSRYAFLTKLAAKPSPTVLYQAPSHFWFYFTCWSTGISMIGWSALTAPVILDQPEGVPDFTKHVYAVSYLLLCAMGFYLIAKTPNVVNSIRLLPSNAASTPGASSSMAAAAAKLQLEVTVKHMLPMLPLRTITTGIENVSFKTRLSHWQHQIPESKLLEMERLEETRRAELRKFDMDHILTMPFRRIGRGLQSLFQGVKSAWTGAGFGFIKVNGKEYKVDVTGGFSHATFRTLARIVDTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKF0</accession>
    <name>A0A367LKF0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6747</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKF0"/>
    <dbReference type="STRING" id="1330021.A0A367LKF0"/>
    <dbReference type="OrthoDB" id="3438840at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="586"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="638"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="666"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="822" mass="87607" checksum="5533F733CA112130" modified="2018-11-07" version="1">MSSSSGQSLAPGAPPAMVATQNASDSETVCSSKQPSSPTLTNPDMILPDDDDDFPMTRTQVPFLDPAALYRSMSLGPSTPIIYGNGTMLSDIGEVTEVESVAGSTPPRRFSSRRCSGAGFPMRTSPTMSRMKRRSSGAQDARRLSIESTGTVIESERIGASADFFDDCISIGDSSFHGDDEGSMASSYADDWGRDVDARYSTDRPRYSTTFISRRAEQILANAKRRLTTMEGNLSRARTLGYSPVSDGSTPSPGGDPPSTPDEDAFYTPTTHSRNASESHLPTPSNPVPRSQRSASALGALGGYRRSLSNSMSVDSLDGRHRPTNMLTYHPLDTTLAPSEGNRKPNDVKESSRASSVASPDPSSGTDADVPRSSVATLQVRDIQDQMQGLKNKIASLRDQARADSLRRRSLQGLRTPSPFTHATWDRGSSEPLDNPGPNLLSPSCVSPRGGSVLVSGANGTPVIEQREPDSPSNATSFHEVRESPSDDGDGGIEGAEFVDDAEDIEGVEAVEIVEWKDDNVDHGAEDDGDDVGYEGEGNTCDECSESGDSLYHDSTPHPISHEDREDAFDYERFFLHSAMGTISQQGFSRRGSISSEDSESSVETTRGPTLTVARRASLDTFTTIDSFATAIEGNSTRNSLALDGPADGFVTPSQVHDKQDADRTSSAVGSSSSDGSGHWQNGRVRRATVSDGAVETFHRPSFSSFESTGTNRSFPLVNKVRMRGGVVTPAGSPEHELKQVADGLMNETASVCDKESLDGGGTQSPAMQMLSKADQMMVEQVVASLGRCVLGLTEAGGAGLASADEFRRRIDAARQVLEAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKF1</accession>
    <name>A0A367LKF1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribonuclease Z</fullName>
            <ecNumber evidence="4">3.1.26.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_6577</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase Z family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="4"/>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKF1"/>
    <dbReference type="STRING" id="1330021.A0A367LKF1"/>
    <dbReference type="OrthoDB" id="527344at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990180">
        <property type="term" value="P:mitochondrial tRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07718">
        <property type="entry name" value="RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047151">
        <property type="entry name" value="RNZ2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027794">
        <property type="entry name" value="tRNase_Z_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553:SF49">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13691">
        <property type="entry name" value="Lactamase_B_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNase Z endonuclease" evidence="13">
        <location>
            <begin position="7"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="12">
        <location>
            <begin position="707"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="170"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="669"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="670"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI14879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="851" mass="93411" checksum="14126DD5B6A08C3D" modified="2018-11-07" version="1">MTSTVELISVPSADTPGTCIWLHHEKRAYVFGRLTEGTQRSFGSRKVNFGSTEHIFLTGPVCWDNVGGLFGYMLSLATMIDSAQSNQEEANADKLSRGLKPLKKQAKYPGLVIHGGENLAHILAACRPAVWRQTLRVSLSEHRTDPRLRDKKNMEPDFSDDVLSVWKIPVQGARSGSPPKRTHDSQEKQKPASTFSDPGPASMIFEGVMFNGRRGPKPTVRIRRVRDVKPGDLAFISHKGVLRSYKPGDGDAKEPDPDTVAWVRDQTKQDEQEKEADNRLLRLDLPPTSYSQTAMSYIVKCHDRRGKFDAPAAAALGVHKTKFKLLTGGESVPGKDGMTVTPDMVLGSPLPGNGVVIADIPSPDYVDGFIQRPEWEDAELMSNMMAMYWILGPGLSSDRRILDFVRRQAHTRHVFCADDTCPNMISHGTAAALHVKLRAIDRQRFPLSVYDNTVSYPSPAPDSPLQLGRAGSASRLMPSAVHDIKLPAPFVDLSDPCKDIGDKILRLAKAARKETSSPAFLARVEAENRDLPNPDAEIVPLGTGSSVPGTHRNVSGTLVHVPGIGAYIFDCGEGTLGQMKRALGEAQTKSILSQLRCIVISHLHADHHIGLVSLIGAWYAQTLADSSSSSDSIPPTLAISCISRHRLMLKELSQVQDFGYHRLRFPNCPPSSSSSSSSSSSPSSPPSWDITDSDHETNLDPRFGLRSITRIPVNHCWRSYATQLELSSGLRIAYSGDCRPSADFASRCKGADLLIHECTFGDDPEMLSHAIAKKHSTMSEALRVADQMQAKRTLLTHFSQRYVKADVLKASRRNDVVMAFDMMRLRLGDFQAHACYAAAIQALMESLGTQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKG4</accession>
    <name>A0A367LKG4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_6990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKG4"/>
    <dbReference type="OrthoDB" id="10514246at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="306" mass="34416" checksum="8AD5C6F08A3E3906" modified="2018-11-07" version="1">MANKSAFSLFSSPRPLRITVCVTQMGPMKRKMQGRAPLNREEAADPKSFLLRLSQNPVRSNIGQRRDVRETLKHAKTTKKRTPVKTLYYLPLHPDPTENKVKVTDLSYKTRRIHRPPRNDELSYWKREEREDVRRNHETLSPPAHLSRQPRASLTGFIRQHKGKNFDSSPFRRPFSIQSQIEYGIERTEKPEFEAPGWREIIDGAGENTCVVRGRNSCPARGREVRGSAQGGYETAAKIRDEALITLRGKGGGREVDEESKGGYTGAAAAQDRAAMDAAAWSSRLVSDQTPCLVGKGDETMSSSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LL57</accession>
    <name>A0A367LL57_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Eukaryotic translation initiation factor 2 subunit gamma</fullName>
            <ecNumber evidence="2">3.6.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_6964</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="2"/>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LL57"/>
    <dbReference type="STRING" id="1330021.A0A367LL57"/>
    <dbReference type="OrthoDB" id="1045173at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01888">
        <property type="entry name" value="eIF2_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03688">
        <property type="entry name" value="eIF2_gamma_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15490">
        <property type="entry name" value="eIF2_gamma_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000009">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000011">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000065">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050543">
        <property type="entry name" value="eIF2G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015256">
        <property type="entry name" value="eIF2g_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044127">
        <property type="entry name" value="eIF2g_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044128">
        <property type="entry name" value="eIF2g_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003077">
        <property type="entry name" value="PRK04000.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09173">
        <property type="entry name" value="eIF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="80"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI15141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="509" mass="55084" checksum="AEA3E9E809AAC721" modified="2018-11-07" version="1">MSADGDPKIDNLDSESESGESLDGQNVGDGKQPLKSALKNSHSVLPDQSIQRPKLPPQTNPKDLDVASLTPLTPEIIARQATINIGTIGHVAHGKSTVVKAISGVQTVRFKNELVRNITIKLGYANAKIYKCDNPKCPRPGCYRSFKSDKEVDPPCEREGCGGTLRLLRHVSFVDCPGHDILMSTMLSGAAVMDAALLLIAGNESCPQPQTAEHLAAIEIMKLDKIIILQNKVDLMREEVAERHYESIRKFIRGTVARASPVIPISAQLKLNIDVVLDAIVNTIPVPVRDFTMDPHMMVIRSFDVNKPGSEIDDLKGGVAGGSLLRGVLKLGDEIEIRPGIVSRDESGSIKCTPIFSRVISLNSEDNDLQYAVPGGLIGVGTRIDPTLCRADRLVGFVLGLRGRLPDIYSEIEVNYYLLRRLLGVKTADGKQAKVTKLAKNEVIMVNIGSNATGAKVTALRNDAAKLALNTPACTSIGEKVALSRRIEKHWRLIGWATITAGITIEPSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLK2</accession>
    <name>A0A367LLK2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_6489</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLK2"/>
    <dbReference type="STRING" id="1330021.A0A367LLK2"/>
    <dbReference type="OrthoDB" id="250175at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00387">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_bL12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_bL12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_bL12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_bL12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_bL12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL12M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="ClpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="Ribosomal protein L7/12, oligomerisation (N-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein bL12 oligomerization" evidence="5">
        <location>
            <begin position="66"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein bL12 C-terminal" evidence="4">
        <location>
            <begin position="125"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI15291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="192" mass="20729" checksum="C4B6F722F67F2C49" modified="2018-11-07" version="1">MAATRDIRLRFPQQKMIIPCQCAARSCSLQLRSLSRVTSRCSQTWRATPTTRRFNSTQATAPASPKIAQLVEQISQLTLLETADLSKLNIPDMPIGGFAAAAGPAPAVVEEAEEEAAPVVEKSLFTLKLMSIDAAAKAKIIKEVKAMLGLSLVESKKFVESAPKMMKENVAKEEGEGIVAKMKELGAVVVME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLX1</accession>
    <name>A0A367LLX1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">18S rRNA biogenesis protein RCL1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_3408</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLX1"/>
    <dbReference type="STRING" id="1330021.A0A367LLX1"/>
    <dbReference type="OrthoDB" id="1911237at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00875">
        <property type="entry name" value="RNA_Cyclase_Class_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.20:FF:000004">
        <property type="entry name" value="18S rRNA biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013791">
        <property type="entry name" value="RNA3'-term_phos_cycl_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016443">
        <property type="entry name" value="RNA3'_term_phos_cyc_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036553">
        <property type="entry name" value="RPTC_insert"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03400">
        <property type="entry name" value="18S_RNA_Rcl1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="RNA 3' TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF1">
        <property type="entry name" value="RNA 3'-TERMINAL PHOSPHATE CYCLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05189">
        <property type="entry name" value="RTC_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase" evidence="5">
        <location>
            <begin position="11"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase insert" evidence="6">
        <location>
            <begin position="210"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI15433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="404" mass="42587" checksum="30E36EFAEFDA2259" modified="2018-11-07" version="1">MSFQQGPDFLRFTGHRDLSRRLTIATLTGRPVHISKIRSASPTNPGLAPHEVSFLRLLEAVTNGSSMQISYTGTTLTYHPGLITGTVAGQGATDGDVILHNIPDTCARGVAYFLLPLCLLAPFSKAHMNVRFSGPGVITSATETGDVSVDTFRTAIIPLFGLFGIPPVRIELRVLQRSCAGPGGRGGGGCVELRFASQVRLPKTLHLNRSPGRVKRIRGVAYSTGVSASNNARMIHAAREVLNPFSADIHVAAQYDQAPLVATGQAGNKRRLGIGFGLSLVAESTTAGVLYSADVAVPPSGGVVPEEIGKRCAHQLLESVAQGGCVSHVSAGTVLILMTMGSEDVGRLRVGRDVIGTEDQFRLARDLRTFGASAWGLRDVEDDTGDIIVSVKGTGVGNVSKKMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LM58</accession>
    <name>A0A367LM58_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LM58"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="187" mass="20567" checksum="34DBBB97906A88C1" modified="2018-11-07" version="1">MFVDLVFLAHSSSFQGGVSRPFYAVRLLLSLEFGVDKMAAESHDHRQRESGEKGEMGNGESRRIKKKEKRGRRGLKGSKKPSLSLNMEGVLDRRRQPVVVCTLIPTTLAETLQLKATKRPEILHTVVLLLASLPHTVILIPTPSPKEGLHRARGTGLESGLLLSYCAVFRGAYCTVSRGTPVGRLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LM86</accession>
    <name>A0A367LM86_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LM86"/>
    <dbReference type="STRING" id="1330021.A0A367LM86"/>
    <dbReference type="OrthoDB" id="4928090at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00049">
        <property type="entry name" value="WILMSTUMOUR"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="194" mass="22504" checksum="71BF6A8791EFDE49" modified="2018-11-07" version="1">MGSSTGEYRGPAKRRLYLHHPEPDVLVSRRRVTRFIPPSPPPPPPPPPPPCYERPPPPCIVEPEPVYYEPAPPCPEPPPLPEPEPEPELPIDVISVDVESSPKKPSRSRSRSRSHSHHRRERHDKEVYVERDRFIPVPVPVPVPVEPRYDTYRYVEGPRRSVPAPPRRAPAMDEREHIHINVGDHRRTRDYHRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LM99</accession>
    <name>A0A367LM99_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_3516</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LM99"/>
    <dbReference type="STRING" id="1330021.A0A367LM99"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF1">
        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="388"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="459"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="501"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="132"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="214"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="19"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI15531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="567" mass="62155" checksum="F21E65C2200C6681" modified="2018-11-07" version="1">MAHDVELANLEFKEDSLTHGSCHSMGEQQHRHHHHHHHHHVDGRVRRFLDGFKRDADSSFFTSDPLRQSATAAASSSFSSSAAAAGTGPGTATGTGGHHHHHHHHHHYYYDLHLAAVESANTGLARKLKGRHLQMIAIGGSVGTGLFVASGKSLSTGGPASLLIAFSVVGAMLYCTCQALGELAVIFPIAGSFSSWATRFLDPSWGFAMGWNLLGIVLNCGGTPDRGYIGGEYWHNPGAFNNGFKGLCSVFVTAAFAFTGTELVGLAAAETANPRKSLPTAIKQVFWRITLFYIVALTLVGLLVPYDNERLIVDGETTTANANASPFVIAIEAAGIQVLPSIMNSVILVAVLSVGNSAVFGSSRTLAALAKLNQAPKLLGYVDRRGRPLVAIAVAVALGLLAFLSDMQHRYPVLDWLLAISGLSTVFTWGSICLCHIRFRRAWARRCRRLDDVPFVSQVGVAGSYVGLALNLLVLVAQFWVGAFPVDWRSMPVHQLVRNFFLKYMGVPIIFLFYILHKIFYQTTYVRIQDMDVDTGRRDFNLPILLAQERAERASWPRWKRFYKFMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMA6</accession>
    <name>A0A367LMA6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3497</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMA6"/>
    <dbReference type="STRING" id="1330021.A0A367LMA6"/>
    <dbReference type="OrthoDB" id="37886at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="594" mass="63968" checksum="90A7EA765BA06F8B" modified="2018-11-07" version="1">MSLAVLSTAHVSTNPGQQQPYSFSPSTLLLERNLSTQNPSLPNVGYPTRAAASADTRSRSPRQADHRHMNTPAQGAMPMAGDVGLPPLPPNAGWAASAPPAAVNPSTLVAPTSVQATSDYRELVDVLSRASPDTVRQVIRDRWENSLLGSDFHTAFILNLLFVSANPAVMALVVQKTGERMVKASKKQILAHLTTNDLDELADLILAKASNEFLDKSMACRLETVSARRLLNALARAERLGYNISDIVEENSETVIASAGSGNSTPTAYPQSLQAQAAASRQASGSPAQMNRNVAYPPATASTSPYGIVHCTRCGRPCSGDQAFRYHAMRRACEHTDKVERINVDICPHCGCLFTSNGGLAYHVKSKVCGDYNGATEQAVIAELRARPVRARGDFASLPTQPIAMASRSGPATPSRVNGSADDPYSKLTPEARRNFEMEMRQAEEKYGAMMHKALSYPAHEREDYLQRIKNSFNSKQSTTRKKYGIRLRERRTKAEIEEDRVRVMNDTAPSAKRSRLDDGTPLQAATGVGGGLVETAAQPALVDPTTTTPAGLPMLAPTGTSDDPMQIADDSSNSTDSEDDDIPARLPPQHLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMG7</accession>
    <name>A0A367LMG7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit alpha, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L249_3421</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMG7"/>
    <dbReference type="STRING" id="1330021.A0A367LMG7"/>
    <dbReference type="OrthoDB" id="9805536at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18116">
        <property type="entry name" value="ATP-synt_F1_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1-ATPase_alpha_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.150.20:FF:000001">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000001">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004039">
        <property type="entry name" value="ATP synthase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="entry name" value="ATP synthase alpha/beta chain, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a_nt-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009884">
        <property type="entry name" value="PRK13343.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082:SF2">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0139">CF(1)</keyword>
    <keyword evidence="6 12" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8 12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="15">
        <location>
            <begin position="310"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="13">
        <location>
            <begin position="433"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase alpha subunit C-terminal" evidence="14">
        <location>
            <begin position="663"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCI15577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="794" mass="86296" checksum="6E19698A46D363E1" modified="2018-11-07" version="1">MGSAESKQVEGRLRQVELSHIDFPERFNIYFESKSRLRLVLGEEKSRPSHIVSMPGGFYGKLVLYDGPTVEAAPVAVIRSGRKLGYYDDMELAASQPGAHHRVEELRCEGKGWSMSYSFVTSVGEGGLPEKFEWRSSRGDEVKSLGEHSYGWKLMRLGSQEEEVVAVGADAKISRSLSKVGAFGFVGRGASGELGDGWAVMAVASLIRIIQRQWQTGITVAASIPKQSPLSPIATLLQLLPSPRLDLDTPHRNSSRAVSAAGRLAVVRNATPAVVGFQARSYADAKPNPTEVSSILEQRIRGVQEETGLAETGRVLSVGDGIARVYGLTNVQAEELVEFASGVKGMCMNLEAGQVGVVLFGSDRLVREGETVKRTGEIVDVPVGDALLGRVIDALGNPIDGKGPINTKEKRRAMLKAPGILPRKSVNQPVQTGYKSIDAMVPIGRGQRELVIGDRQTGKTAVCLDTILNQKRWNNSNDEDKKLYCVYVAVGQKRSTVAQLVKTLEENDAMKYSIVVAATASEAAPLQYIAPFTGAAVGEHFRDSGRHSLVIFDDLSKQAIAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKLNKDHGGGSMTALPIIETQGGDVSAFIPTNVISITDGQIFLESELFYKGIRPAINVGLSVSRVGSAAQLKAMKQVAGSLKLFLAQYREVAAFAQFGSDLDAATKQTLARGERLTELLKQKQYSPMAVNEMVPLIFAGINGYLDSVPVDKILQWESDYLAHLKSNETDLLATIDREGSISKETEGRLKEVTQSFVKSFLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMI8</accession>
    <name>A0A367LMI8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3602</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMI8"/>
    <dbReference type="STRING" id="1330021.A0A367LMI8"/>
    <dbReference type="OrthoDB" id="4156126at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="578"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="693"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="815"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="921"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="290"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="702"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="718"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="819"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="927"/>
            <end position="936"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="994" mass="107482" checksum="BAD759CCA6F2E41D" modified="2018-11-07" version="1">MNAAHMRQRSASHGSLNSAYTDTCRAHGRLAAGTTSTIKPSSQRRPLRSVNENAALLRSPGPLESMLKKTTETGDIGVFTIRASIPPPTRQRSRSHVPDAGLVSGPPAKMMDDGRGQDEQRYFRSYRDTTSEIISLYGSDNNQQHWLSSSASPFADDGHRSYSLTTCSSHQIPSQKSSGTLQSQSSGGYGSLGRSRSPLPYPTRLKRPGIRTPSQALVDNGSMDYGRMGEYSLVLWLAYASSWPRQRAAYGVNKYPHGSRRPPPLSIRADVNRSTASLPSGASPSPYNLGPGHIRSPSSSISGRSRPHDRHRGSSVDHSPRSASLTSIVEMYQRPATASSGVAALRPGGSFYYDYTEEFEKPAPLVPRTEFQAPLCPVPQRAGDGSRHMVLREDSQARLDAISSGRGRGHVAATRTDRGLSTPADEPRAETHDEHHHLGHSGDSMDKLLAGPSRPGIAAASDNGPAVKESASEPRVTDDAEAQACPPVLECAQDDVKLQPGRRGVWLLPKPFAAEADFPQNKPSSLIKPRNTLDPSLSEFASLFSSFDRLAKSPLSHGDGETSTTRIVYCPPSNIDDLDNDYVDSDDQGDCGDGEKNEEDDQVSLDAFVPKHLTSRPSLQLFDDFAAEDQARNRRHRRNGAALRINTAGLGDVAGSRQQLSPPKEELTMICPEPISPARQLKVTKSVPQLMKALPPLPGEATGTSGREGTRGHQTGKQSRDFRVRDSLKSDDACIHPSWKAPETSPPKLKLRVKAASSSGAVSDLKAAFGSGDREGQWNSNAAVKPKLKLKVSRSRLGQANRLKQCNSLADLAVRGQEVEEEEEAEAEAEAEVGAGAGAEAGVGAEAEVEANGERNSLAGWESREGDSSGSDQFNIAYPPCADKSELLQRRSSLPSKDAARSFTWEAERRGLRQKLSMFRLRLTRGPTKEAEDSKTTTDAAAVTDGSDQARGRAISSTRSERVGGRVRRWASDAKQAVRLYVRRRLDGSSRMSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMQ0</accession>
    <name>A0A367LMQ0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMQ0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="258" mass="28291" checksum="3F71B19B1AA61CAE" modified="2018-11-07" version="1">MCSPAGPTDPPPGARHGPVPSAEIALALALALSRQQGDLKNGNGKLKNSHDLFYRLTPNKTLSPNQPSFRQAEEAKSQQTLLLPILRTLTRLGSARRRRRRRRRLGCGGGATLVRAALELKVHVGVHLSNRLAVLDGDGQHAGAEGGEDDGGAQLHFGWEKSCCWLKWLRSFLDDGEQSHRSYTQPRFPPLLFSSPLHSNSAPPPYHPNKMFQTIDITIQTSSSAHPSPRLFRIPSNSAASLFLLMIHNRNCVINPAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMV5</accession>
    <name>A0A367LMV5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_2975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMV5"/>
    <dbReference type="STRING" id="1330021.A0A367LMV5"/>
    <dbReference type="OrthoDB" id="4923119at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="565"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="702"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="796"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="702"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI15774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="960" mass="108430" checksum="6CD7431F93ECE2DB" modified="2018-11-07" version="1">MNQTYNVYIYVSLRASAWMSYILIRMKDLLLGDKRRDASREENFRTTATIGGKPGMGIFFLVKVSSSVTTMTLALLCSVVVMLPAVLATTSGAPPYEWYLGRENCKDNMTEACLGTEVWCFDKTMRGEYESTESCYSLRRRMEWFDPAAAPHHGCPDQSESCLGTEVFCSLNRNSWDRDKCIIARKKTPWRDGRPDACPPAGPETELCMGTRDWCRRDDAFKFYSSEELCLSHRSRGVIVASTTTTTSSNKTTEDGGDPCDKDPSAADGCLSKEMYCLGISSQHLRQACLRERQRLRYYHRNSAECKDDARGDQSEACVGTVAWCQHEDRIKLWGSTEDCLAFRNGLMPLHYKSRRCQEEAEEEAEECIGTEAFCMRKPGRAQRKQCLESREPHPFLAANSTGCPGPGAEDERCMGTTAWCKTVPGYYYYDDVVNDCLRVRGFVYEDLKKIARKWLEKRYESQILTHGKVLGRASFFIELGQLRFTDETALQLRERVRYTLSRFVHRLWRDARRTAEKGVPAVVAQQRWMDGLIDRETENGTGRERPYPYTRIKQSTIKDTMMQDDTTSSIHPSIHPPPPAQGGRQTRASFLDDALSIARACCSVSSRASGSSLSLTTDRNSKPRILLQASVGPTYLATTLLQSRPKEGRPAVVAQQRWKDGLIDRETENGTGRERPYPYTRIKQSTIKDTMMQDDTNVIHPSIHPSIHPSIHPPPPAQGGRQTRASFLDDALSIARACCSRLLQSLGSSLNLYDGPLLDNNLETTDRNSKPRILLQASVGPPYLATTLLQSRPKVNHANPHHITGERKKKKNSNIPAPPQAIRTREITHAALRTRPTARVLLQRRTQVFSLCPYTLHFRRRRRQSLADDHGGRDERDPQRDDYCEHCSGFPFLKVVPSLVSCLPFLSNVLRVVAREKDEKGGAVFIHLPRYGIAISCPRLPSSDTGLKARDQEGDFESR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMW6</accession>
    <name>A0A367LMW6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMW6"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="314" mass="32746" checksum="ADD75FCD0AC2727B" modified="2018-11-07" version="1">MTAISTARRSLAPIDVTAALYSAPIAGVVAGLRPNWYNLFQMPLALSEQGGSGSSSRSNSSRSSSRSNARPRGEGGRASLPPAIGGEEGGKRAKLAQKAAAAAALIAATASTNDFARNEAERSGGGNDNNNQDANANGNDKHYANASANDDKRLADATTNSDNDYYTNTAAEVDNYANGAADADRAEAVAAAAIAAANAAAAREAKKAVFTAAMRAKRREEARRAAEKAVAPALARAALAALDKEPAVAADDNNNSDGEDEEEEDEDIDDNNDYNDKPAPRAKETKKTEKKKAVGAVRAYPCVRCISQQQECRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMZ2</accession>
    <name>A0A367LMZ2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_2759</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMZ2"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI15770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="208" mass="23967" checksum="AC40A8EF63404630" modified="2018-11-07" version="1">MHCLWRVWIDVGLTHPRLLLLSAPVDSQPMFFDRHRARASLGTDSLAFQGAAIRLPRSLVPVLDMGARVRIPHTQARICIMSSSALPPPFFLTPPGATIQFHRPSDESPSSTNVTRCFIFSLRPEICRFPHADSRTWTWTYLNSTDHRYDQNFKPIFTSIQQKNIIAPPEKSERFPPFLTHFAQLCNVSRRRRSRFEQQEMPPGRFAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LN16</accession>
    <name>A0A367LN16_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein sly1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_1919</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LN16"/>
    <dbReference type="STRING" id="1330021.A0A367LN16"/>
    <dbReference type="OrthoDB" id="10251230at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055449">
        <property type="entry name" value="Iec3-like_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032742">
        <property type="entry name" value="Iec3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24244">
        <property type="entry name" value="Iec3-like_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14612">
        <property type="entry name" value="Ino80_Iec3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INO80 complex subunit 3 N-terminal" evidence="3">
        <location>
            <begin position="756"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="domain" description="INO80 complex subunit 3-like middle region" evidence="4">
        <location>
            <begin position="845"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="705"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="810"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="858"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="973"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="725"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="875"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="890"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="986"/>
            <end position="1010"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI15808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1103" mass="120845" checksum="FA647CA6C18AE6F8" modified="2018-11-07" version="1">MASKGNSLRDRQISSLKKILNLNETIDSSEADEAQASALLAPVGPILDADGNPIWKLLVFDDLGRDVISSVMRVSDLRSMGITMHMHISSPRHPIPDVPVIYLVEPTARNLQGITNDLQRGLYSPAYINFLSSLPRVLLEDFATQTASAGTSDQIAQLFDQYLNFIVAEPDLFSLGMQKQHTYWALNSARTSDEELEAVVDRVVSGLFSVVVTMGVIPIIRCPKGAAAEMVAARLDRKLRDHILNSKDNLFSGPRQAAPSATPSSRPVLILLDRNVDLVPMLSHSWTYQSLVHDVLDMKLNRITIETANDENNAAKGTTKKSYDLSANDFFWAKNAGVPFPQVAEDIDAELTKYKEDTASITKRTGVTDLEDLQADTSASAQHLKAAITLLPEMRERKGILDMHMNILAALLSGIKDRQLDNFFQVEENVMKQPKSQVMDLIKDDGKGKDPTDKLRLFIIWFLSTEQEVSRTDFEAFGKALEVAGADVSCLAYIRQVRATTKMTQLTTINNNTPPNAGQQASSDLFGRFSSISSRLTDRLKETGVPTGLSSNFESLISGVKNFLPADRDLTVTKIVESIMDPSTAASSAMAKTEHYLYFDPRSANARGTMPPPSTIRAGSGAMGAPGGMPGAQGGPGQLATFGQRRQGFSEAMVFIVGGGSMEEYGNLQEWVSRTGGDRGRKRVVYGSTELVNAKEFIREELQRLGDDLGSVSPAPAAEAKEEEKMEEEEEEEEEEEEEEEEEVVVVRAVAAGGYKSWKKKYRKMRIVFDRKMQQGEELHRKEDRASAMVKRLAVENDRLLDLLLEINNSPQMPPERRIDVSLPSTPSLFTDNEKPSSPPSTTLKRLVQLLDEVPHSSYRDAKDARPPYLADLTAPDDDDDDDDDDDDNNNNNNNNNNNNNAARPANFLSADDIDNYVHAIDTAIDPEAHIPTLAPRAHAASSTNAHLKNPTSVTNWLRKNAPKIFLQDAENNNHRNTSADDDPDATNAPPQARKARNSTSAPSASAAPPRSERPKSTNKSKRPRLAPPPPDGDTAVEDADGDATPSSAARGKRKRDEDPGYRPGGSSSRPAKKKRKSDVDGTSSTANRSKKDAAGSGKDGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNB3</accession>
    <name>A0A367LNB3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2032</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNB3"/>
    <dbReference type="STRING" id="1330021.A0A367LNB3"/>
    <dbReference type="OrthoDB" id="5385072at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="349" mass="36741" checksum="89E089375AE949C3" modified="2018-11-07" version="1">MLEPQRTRPIETYGPSRPRPGSSDAFPLPGQAPIQMSLHLASQPGLPAPQSRRSPSVNTFSTASSIPPPAACRTSSNTDLRRSISSRSAATSNQPTSYVALLRKQKATVWCDRAQYEDPRVAAQQRAAKMRANLEVVTSGRPYSGSRTSTGISATGKVAAKIRHHGKTPVVGYAPGENHVGVGGVPLRLSATEVEGESSGDDDAHAASRLHHRRTGSSGRSSTASGRRGITYRSSSGHGPQGGHGPQGGQRWSPGDTPERPGSLAGQQPDDATKTLDDAASGRSGSSAERADNVAELGSGPRLANNSHLHSSLTRERSVKSAEELRRRGSVDERTATLTSGRLFIANPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNL8</accession>
    <name>A0A367LNL8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial zinc maintenance protein 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_1747</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Assembly factor required for Rieske Fe-S protein RIP1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane. Modulates the mitochondrial matrix zinc pool.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with RIP1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I LYR family. MZM1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNL8"/>
    <dbReference type="STRING" id="1330021.A0A367LNL8"/>
    <dbReference type="OrthoDB" id="529194at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20267">
        <property type="entry name" value="Complex1_LYR_LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045298">
        <property type="entry name" value="Complex1_LYR_LYRM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050435">
        <property type="entry name" value="MZM1/LYRM7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46749">
        <property type="entry name" value="COMPLEX III ASSEMBLY FACTOR LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46749:SF1">
        <property type="entry name" value="COMPLEX III ASSEMBLY FACTOR LYRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI15999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="108" mass="12348" checksum="9E39D45790066C2F" modified="2018-11-07" version="1">MSTRSVYKELLRAARITFKANSRLQGDDHVFAAARIKIRHCFRLEASLEPSSQEAQKARDAAKEVARFLRSNIVQGRRKHPDDDTYALRIHEHTELGDNETIGNTCKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNQ2</accession>
    <name>A0A367LNQ2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_2501</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNQ2"/>
    <dbReference type="STRING" id="1330021.A0A367LNQ2"/>
    <dbReference type="OrthoDB" id="10263751at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI16011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="133" mass="14473" checksum="87CA01216D638CD8" modified="2018-11-07" version="1">MDETDSCTSDKVPEISSMDQLDLLLRQNRFLVLQAHATWCGPCKAISPLFRQQAEDLAVPDLLAFARFDSGRAEELVNELGILTLPTFVFFEDGKKVRALAGANHAALQKAVEHIKAKADGASPAGDDDDNDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNR0</accession>
    <name>A0A367LNR0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNR0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="145" mass="16215" checksum="BD72DC7F9847B5E8" modified="2018-11-07" version="1" fragment="single">FIENKDAYQTPPKRSTRVGVWLHHYTTSGKHRGVTCMCSYVCSMFVVCLQTGGCHVVECLIMIVYVRRRRTHVRRAASTTEIKHVTVIIMTVDGQSSSHCRLGIDLISSLLSPLARGEDLDTTLCVFYPSIRPLPLPCSPSLSFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNX3</accession>
    <name>A0A367LNX3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pathway-specific nitrogen regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNX3"/>
    <dbReference type="STRING" id="1330021.A0A367LNX3"/>
    <dbReference type="OrthoDB" id="5369448at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="531"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="531"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="610" mass="66618" checksum="2B4CB9996C68CAE2" modified="2018-11-07" version="1">MDYVTPPQDTPTDQSSSLDDGRGSSSSDDDHSPRSSLGSMSEAEQTKIEQTLSQRGIAQRSRSPRISEPPPSEADDDFIPTLRGTPRPPFRSPSSVQALQRMTSPPPPPTVGTPPLSGRRGVPAAIISRSGSPRKTPPRFRRATPPLVLLHVTLLPLAVWRWAAVLDRARPSQLSPEAVTLRHAWRQLLHRTGDTVSDRGVLLPHPQADYEVLEERLLEALELPLQRRARILECGHYLGPADELLSVDEGEEGEGEGEEEEEEEGREDDDDDEDDDRKDGGDEAKKTHWCRTCRSDIRYDSLGEGKVFRVNVYASNGLMRAGAWAACWKEMERVDVELEPIVDATLHDELARLADEMLLMTPDDKEQEPAELDSSPRLLDTDETTAAYNHDLPTPPSSPAVPRCRRPVHDDESSSSLLSLLLEALRLVFLDRKNVAIALLSVFVLMLAVTPRFYSSRLTVREEPPALFQAVKEPTLVHGQQHAAMAISSSDSGPEGPTPSRQGVMTSVHVRDPCALCSLSTSTLRLVETVTTTETRTETISLEDDGLESTERSSLSVETSSPTAVKAAEALAALASGFSSPAALESGSSSSALLRSVNGGRFSVDSHHDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPV9</accession>
    <name>A0A367LPV9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPV9"/>
    <dbReference type="STRING" id="1330021.A0A367LPV9"/>
    <dbReference type="OrthoDB" id="5245631at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013268">
        <property type="entry name" value="UTP16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08297">
        <property type="entry name" value="U3_snoRNA_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="281" mass="31507" checksum="029ED83EAFC719F2" modified="2018-11-07" version="1">MVPFSKRKADQESATENPSDAATSKRQKLPVRAKAVEKGTLLTFDDDGNAEQTAASFSTRPIRAEKQEFKEDSEDDDDAAPEALSTARVATELKQSEQAVQRSARKKAAEEKQKRQERDTLLKKQAEERKRTAHEAVVAAADDRPPQDDGREESPSNKMPTTTGGRRRTEKTTIPDHLPAELLDDSPSEDEEQEPERRQTTTKSNQGRKRKNVAEIESRLTRLDKAPRDEVVRSTVFRVAAKVDARLAPKAGKKSLLLRQRLLRRKRTVVVGRRGFSSATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQ58</accession>
    <name>A0A367LQ58_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_2783</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQ58"/>
    <dbReference type="STRING" id="1330021.A0A367LQ58"/>
    <dbReference type="OrthoDB" id="5420905at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052973">
        <property type="entry name" value="Fungal_sec-metab_reg_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="172"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="505"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="232"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="173"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI16558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="959" mass="107250" checksum="B97900B0FAC9E3B8" modified="2018-11-07" version="1">MVLDCGLTASSSTTPQPPSPFSSFSSLTEIPDLTFWRLLRAPLGGSSQRLLPTGPFLGSNSRLQPGIQSHRQRAVSAARPGILPALAVGTRPWLLPLLLPGLPLISQSISMSFDFGNANGGSDGLLDLAFDHQLRDRAAYAFPATTHSSPSVASGVMTNTRMWPIPMDFTAAPHHHHQHHHHHHANAASSPEDVQGSSPLSNSSSPHSQHSSLHQSPFQSASNPLTDWTLQQQQLLQQQQQQQQQQQKQKQQQQQQQQQQQQQKQHQQLPAQDLAQLFPDPATFMSFNAFPAAFPPNSLDYLPQSQSALQANLLESTFNAMPSIEETAQAMQWGNAGMDNWQDLQQTLQIDGLHRLDSVGSNSPTGTYLEVLSLPSSDGWAMVEWGQPQLDQFQQAEAHTAAIFNPSQTLHLRTNSDSSEGANSMDFGSFEEIAPFPFSPFSPDSDVFQDNGHRNRFSGDGRGHHQELISPTAAVAPVPIIKSEPVGRHSPGTGVVATSPPVVITTRRNSGPRKSPIAKAANSRPVVRRICNGRKDGSVEKKVGRRKGPLLPEQRKQASEIRKLRACLRCKFLKKTCDKGEPCAGCQPSHARLWQVPCTRIDIKDIGYFMKDWKADYERHMDRGVSIYNVKGFSQKETLMWITHGYGFALPVMVREVYVADDGCFSVEWVETCRNDQEPIDFEARTEKLDVGAEGVRIDALAEYLDKHIDGPFEDFIDDHFEGTPFITEILKTAHRFYVKERMPVIKKALKLVLAYNLTMHITMVESQGSEVALDGQIDDEESKFYGRTVAPVMINFQVKCALADMWRELQKDILEELSTLYSGVYSGEKMKNWPTIFMLASILLAVWEEMQFDCHYRVPDPAAVNKFCNDMETTPVGVIVGLFHAISQKLPAFTDWDTCQHGHLLHNNTSVCEAMTEVRQHVIKHEAYLRTRKKTKFDRWDFDSLSNKFLSKLVIRAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQH3</accession>
    <name>A0A367LQH3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_2571</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQH3"/>
    <dbReference type="OrthoDB" id="3357002at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021460">
        <property type="entry name" value="DUF3112"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35184:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35184">
        <property type="entry name" value="YALI0C10208P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11309">
        <property type="entry name" value="DUF3112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="297"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI16637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="493" mass="54684" checksum="FE3EB4A3F736A9BF" modified="2018-11-07" version="1">MTVLFCETMSRKARNMVVDAKQPVRIYNETAARSPEPTFTSAVDMATMSSFRPATSSFRPTTSSFRPTTSSFQPTTTSLPDDGVSLANAAAVDPIDGPFYGGVPNSTEDGLVTFIFLLLFALGAFLHLVRLIQNNKRRHRFLLSMPIIVFCISRTVYCIFRFAWAFLKPPFPRGVVAMSVILERDWFAVLLIPNLIIVRRIIRAMHPDFGWNKLFTMAGNALVVSIAPVELMSFIAFFVGIFAFGRASVPGIKQALELAASWNLMLAYLPLVAVFAACAVPGPAIENFGSGSFRFKTALLVFNSITLAVGQTMRLALVDNPEAALEGSAIAGKAVFYTTAFFLECLTVFSYLIFRFDNLYWVPDGSHGPGDYSRGSGDGNTEWTREQIKAEINKLGIRYELLESHDQDSLSPLYALIYPSEVADEGGEEEEEMEARWPSATLSTSSTLKGRQPPPSYVERSVERLTVDPTQATRWPHRRTSSWDSVDEAKMFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQW5</accession>
    <name>A0A367LQW5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_2029</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQW5"/>
    <dbReference type="STRING" id="1330021.A0A367LQW5"/>
    <dbReference type="OrthoDB" id="5284712at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451">
        <property type="entry name" value="MARVEL DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451:SF3">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI16801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="29234" checksum="52A8D1FEBBA85993" modified="2018-11-07" version="1">MVKWDPDNVPRTKLVLHTLQILLVFTIWCLEIAVFVAKDAKIVANNAFPFAMCFVSIPAWLYLMLAPRFDRGRRIAEPSAMLVIDVLFTILWLAAFATQAAYNTANLCGQRCNLSKAIVGLGIFTTLFFAATSLISAYTLRYYNFHGTLPGYDSRKLLPTNASTSAIDPDKAAFSTGDEDYERVNLDDREPAAAATYSDSGRYAQANPYSADDFADPNRYSPLPPRSNDLFNTDTEYSSGGAAHKPYADEPARFPAGNYDRAHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LR60</accession>
    <name>A0A367LR60_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mannosyltransferase</fullName>
            <ecNumber evidence="12">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_2985</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third mannose to Man2-GlcN-acyl-PI during GPI precursor assembly.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 22 family. PIGB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="12"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LR60"/>
    <dbReference type="STRING" id="1330021.A0A367LR60"/>
    <dbReference type="OrthoDB" id="416834at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF4">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="357"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI16936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="576" mass="64696" checksum="0F6876EB6FB3B196" modified="2018-11-07" version="1">MAELLARCSRQGRTVLTALVAVRLVNAWSIATFFQPDEFFQALEPAWGLAFGPHSHPWLTWEWHHQLRSSLHPLVFALAYKLADVLSSWLPGGVTVRAATIMAAPKLVQAVFAALGDWYTWKLAVDIYGPDSNSSLAVLVLQLSSPWQWYVSTRTFSNSAETTLTAMALYYWPWQVLEPAVSAKENPKPANPLGCQARRRASLCLAALAVVLRPTNVLIWATVAFLALTRFSLQGPSPLTRSSARVLIGDAVLCGGAVLAVSLVSDRLYFGSWTFPPLHWLRFNISQSLAVFYGSNPWHYYLLQGIPLLCMTSLPFALWGLCRPASIDRANTVRTLSATIFATVGVLSLVSHKEVRFIYPLLPALNMLAAPRAASFFFVASQKRTRRLRHRPYLLAALCINAVLAGYLGLVHQSAPLAVMTYLRHEYQRIMPPSSPNDGPDSELFALFLMPCHSTPWRSHLVYPGLDAYALSCEPPLDTRPDSRQRADYRDEADRFYDDPLRFLQTELFAPDRHMRAPRYFVAFESIEPVLRRFLFDTDEGRRLGVRRLDVAWTGFNGFFNDDSRRAGKMVAWATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LR82</accession>
    <name>A0A367LR82_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chorismate synthase</fullName>
            <ecNumber evidence="4">4.2.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">5-enolpyruvylshikimate-3-phosphate phospholyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_3057</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the chorismate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.5" evidence="4"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LR82"/>
    <dbReference type="STRING" id="1330021.A0A367LR82"/>
    <dbReference type="OrthoDB" id="1721239at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00090"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004107">
        <property type="term" value="F:chorismate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07304">
        <property type="entry name" value="Chorismate_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.150.10:FF:000004">
        <property type="entry name" value="Chorismate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.150.10">
        <property type="entry name" value="Chorismate synthase AroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00300">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000453">
        <property type="entry name" value="Chorismate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035904">
        <property type="entry name" value="Chorismate_synth_AroC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020541">
        <property type="entry name" value="Chorismate_synthase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00033">
        <property type="entry name" value="aroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003793">
        <property type="entry name" value="PRK05382.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085">
        <property type="entry name" value="CHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21085:SF0">
        <property type="entry name" value="CHORISMATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01264">
        <property type="entry name" value="Chorismate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001456">
        <property type="entry name" value="Chorismate_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103263">
        <property type="entry name" value="Chorismate synthase, AroC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00788">
        <property type="entry name" value="CHORISMATE_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00789">
        <property type="entry name" value="CHORISMATE_SYNTHASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="35"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="296"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00081432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI16921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="405" mass="43022" checksum="4193FEF1F4067A3A" modified="2018-11-07" version="1">MSSFGHFFRVTTAGESHGKSVSCIIENCPPGLSLSESDIQPQLNRRRPGQSSITTPRDEKDRVTIHSGVEAGRTLGTPILLTVPNEDQRPADYGGKTVDLYPRPSHADWTYLDKYGVKASSGGGRSSARETIGRVAAGAVAEKWLREAYGVEIVAFVSSVGAIRLFPDGDDDNNNNPPMTLRPAFVDLVNSINRDVVDEFLPVRCPDADTTRRMEKRIAELRDQHDSTGGTVTCVIRNPPSGLGEPCFDKLEAVLAHAMLSIPAVKGFEIGSGFGGSAMTGSRHNDPFIAAPVGSDAEAAERGGGGIPRSRLATSSNNSGGIQGGISNGMPIFFRVAFKPPATISQDQTTARYDGSAQGVLAAKGRHDPCVVPRAVPIVEAMAALTIADALMAQHARHVGRQLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRD0</accession>
    <name>A0A367LRD0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">MutL C-terminal dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_3214</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRD0"/>
    <dbReference type="STRING" id="1330021.A0A367LRD0"/>
    <dbReference type="OrthoDB" id="429932at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032300">
        <property type="term" value="C:mismatch repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="entry name" value="MutL, C-terminal domain, regulatory subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF47">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="3">
        <location>
            <begin position="545"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="424"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="451"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="793"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI16971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="793" mass="87105" checksum="FEEF2B712E5FC7BF" modified="2018-11-07" version="1" fragment="single">MSSVIKRAHHGLARVMSIRRLPDHVIEKLRSSAVITSLNSAVCGLLKNSLDGGASRVLIRLDYARGNCSVEDDGLGIVPGEFREDGGLGKLHHTSKTSPSTRIHGSRGDFLASLAGLSLLSITSRHQGHRSQSSLAVHNSKVLKRQTTASADQLWATFDHGTRVTVHALFGSMPVRVKHQAAVFSARSAVDREWARLVHEVVALLLSWPSEVSVLLTESAVGRELRLKSSTGVDLATRSSRLFGQASLADAEEAGSWIPISASSRYVRVKGCICANPVISRRAQMMSLGVQPILNTYECNFLYEAVNQVFDDSSFGVVENTTGKPRKGLERWPMFYLQIMLPNSEMNALDMSNESHRVVGDIVHLLKALSFEFLKKQCLRPRAIDFQGRSTRRGVATARIRPVSQMSPRKLQLDDWPHVKVGHASRRASNGAGTPRLVGEGGKLLGMPFEEGPRQTDAEPRDEPQSQAGGRRRRRLRVLGSTTAAKRQPSEWLQAVLESWQNPVFETAEATIPSLHACGDVVRFDSKSVPLEGRLSRSALGSAEVIGQMDCKFILVRLRLRDGGEGEGEGEATGLVAIDQHAADERCRLEELCLGYFDGDGDDAVSEALERPILFEASGGEGELLRQYREHFAGWGVVYTLDGHERVRVTRLPPSIAERCSGEPRLLIDLVRREAWALADGVVTARKKGEEEEEKKKKKKKKMGGGLSWPSRLRGCPSGILELLYSRSCRSAIMFNDELSGEECASLVRRLARCAFPFQCAHGRPSMVPLADLGMDGGRDLREGRAVGVEGWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRL0</accession>
    <name>A0A367LRL0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidase M43 pregnancy-associated plasma-A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_2307</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Secreted metalloproteinase that allows assimilation of proteinaceous substrates.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M43B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRL0"/>
    <dbReference type="STRING" id="1330021.A0A367LRL0"/>
    <dbReference type="OrthoDB" id="536211at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008754">
        <property type="entry name" value="Peptidase_M43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47466">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47466:SF1">
        <property type="entry name" value="METALLOPROTEASE MEP1 (AFU_ORTHOLOGUE AFUA_1G07730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05572">
        <property type="entry name" value="Peptidase_M43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016803463" description="Peptidase M43 pregnancy-associated plasma-A domain-containing protein" evidence="10">
        <location>
            <begin position="20"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M43 pregnancy-associated plasma-A" evidence="11">
        <location>
            <begin position="112"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI16990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="362" mass="41106" checksum="110C76B54DE63391" modified="2018-11-07" version="1">MVNFFFLSYFVTCIVIVFAASPPKKHRPRRKAIQVPDFPPIQIDVHAHIYVKKESTHRLTRRALDKQMVILNGAFHDIRANFVLQTAEWIVDDRWAVGVDLGNMSFENYQGNYSALNIHIVEHLGPPFRDKHGLCSIPFAGSFIDDSCVFSAYNIPDGPGSDSPLLEDKPLGKVMIHGVGHWFGLHHPSRGLCHGYTNRVPDLPVMLNVEGCPAWGDTCPQQPGYDPIHNYMVYASTEKCKAEFTPGQLVRMRHNWDTYRAKGRRRTSLELTRLRMLRQTGKLPYFVAPSRTSVDYKIMTMLCSPDRNGVYRELREDYCGTAIYCRNELFRIANGGGGADAASMSWRECLSRRTDTDDGFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRN4</accession>
    <name>A0A367LRN4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_3254</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRN4"/>
    <dbReference type="STRING" id="1330021.A0A367LRN4"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF33">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="4">
        <location>
            <begin position="88"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI17079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="702" mass="76519" checksum="C46316F91110E8C3" modified="2018-11-07" version="1">MAYAAEVGQLNAPPSPGQPYGLPIPGSERPGRTAVYRHLHFHDRPLVTTLDPTIRSVNDGFENSVRLNGKKNCFGTRKWLPESRTWADRFEWMTYDQVALRRKNFGAGLVEAVQRAGCRQSKYGVGLWSLNRPEWHIADLGLASQSLFSVSLYETLGPDTTEYIINHAELVCVVCSLPHIPTLLKLASRLPTLKVIVSMDSLDDGEPAGSSKAALLTQMAEPHGISIYSMPQMEELGAESGRPINAAGWDDISTINYTSGTTGPPKGVVLTHGNTVSSLWATRLSSNIYADDVHLSYLPLAHIYGRLVDQAAIAAGASLGFFRGDMLGLVDDMKILRPTGFISVPRLFNRFHSAIRAATLEADGIRGALSRRVIASKQAAMLAPPGKASNKNLLYDTIWTPKVKAAVGLSRVHSMVSGSAQLDPDVQQFLRAAFAVTFSQGWGMTETNAVGTLQMEGDFSIGNVGGPMASIEACLESAPEFEYSVDDKPHPRGELLVRGTSLFREYFKNPEETAKTIDADGWFHTGDIAEIDSLGRFKIIDRKKNVLKLAHGEYISPERIENVYLGGTSVVSSAFVHGDSKESSLVGIFGVEPESFVAFASKVLGKKIAVDDTAALRQAAGDAAVQKAFLKVLDDIGRRHKFNGYERVRNVHLDLEPFSVDNGLLTPTLKLKRAPAAKAFRSHIDRLYAEINSEASTKRAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRR4</accession>
    <name>A0A367LRR4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_2343</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRR4"/>
    <dbReference type="STRING" id="1330021.A0A367LRR4"/>
    <dbReference type="OrthoDB" id="5327538at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="2">
        <location>
            <begin position="142"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI17109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="477" mass="54436" checksum="B69BBD04B9B4CF27" modified="2018-11-07" version="1">MPLWMCDHEGCRRAAVRNLGDCLLCDHHFCSYHLRPEIHTCPEWEDADAYDPACREAEKQELTDLMRKINISALRARASFLRQGKPCSIPPVKYDGASRSSVMGGMNFHVEIVFEDGVVWMARFRRSNATSPPAAIRDYIMRSEVATLMFLEKTSVPTPKVYDFELEHPGNPVGPAFILMEKLPGKSLRWSIATPQQRQRVMSQLADVFVELHKHPFRSFGSLDTPGESHIGPFARESLTTLVKSEMRTTGPCSGLEDYYTSFLQLILDLILQEELYSRQAVDAYLIHRFLLELVPLVVPSTQDDENFYLKHADDKGDHILVDDHFNITGLIDWEWAHTAPPQHAFNSPICLLPVADFYNGNNTLGGDEIIFSRLLEEKGHSGLARFVQDGRVQHRFAFCCGYNLMDWDGFLGLFRGLRDAVGIDNNLDWHDWKAVALQRYKSDLGLLQLLKQHERFDTDNSPSDGIDKKHEQRSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRS9</accession>
    <name>A0A367LRS9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_2362</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRS9"/>
    <dbReference type="STRING" id="1330021.A0A367LRS9"/>
    <dbReference type="OrthoDB" id="8064436at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014751">
        <property type="entry name" value="XRCC4-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42067:SF1">
        <property type="entry name" value="MITOTIC APPARATUS PROTEIN P62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42067">
        <property type="entry name" value="YALI0C15378P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58022">
        <property type="entry name" value="XRCC4, C-terminal oligomerization domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="205"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="150"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="320"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI17154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="330" mass="35602" checksum="F067F00A687EB946" modified="2018-11-07" version="1">MDSAPVLKVPRSDGAGCLLARASSTGTAPFDLRLVATEGQSPYVCDLRHGRVASLRAKNCPVSEQEWEQILGAVLHREQIDDIQADASVQAGVSASLTIRKQVKGITQRLGSITLRCDEGERIELFEWCTHSLDALYKANESTTSLAVKAEDQEAELVDLRAQLEALMQAKKEDEAALLLKFRDLLNEKKIKIREQQAIIASLPRPGYCPAESGPMKRKLESIKSEEDSEDDGGRGAPEAGTGRYDPGDTSDATASEAGDDDEEQVGSNSDIGDRRMGSSSPNKDGDRQAPSTKPAAQAPPPPRKLPFAANNKAQAPPPPEEETESDDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRY4</accession>
    <name>A0A367LRY4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Striatin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_3193</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat striatin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRY4"/>
    <dbReference type="STRING" id="1330021.A0A367LRY4"/>
    <dbReference type="OrthoDB" id="727118at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013258">
        <property type="entry name" value="Striatin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051488">
        <property type="entry name" value="WD_repeat_striatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653:SF0">
        <property type="entry name" value="CONNECTOR OF KINASE TO AP-1, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15653">
        <property type="entry name" value="STRIATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08232">
        <property type="entry name" value="Striatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Striatin N-terminal" evidence="8">
        <location>
            <begin position="29"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="523"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="720"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="177"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="263"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="539"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="664"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="177"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="263"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="540"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="563"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI17178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="799" mass="86110" checksum="855C67AB528556CF" modified="2018-11-07" version="1">MGPNAGNGMDMGMAMHGNGTNQPQPTEYTLQGVMRFLQSEWHRHERDRNAWEIERQEMRGRIASLEGQARRADASQKALRKYVSILERKFHDQTGQMIDDDRAATIQEKLQTLSGEKAVDEDGQRNELKSFLDQCQAEFMYLMVTPVNPQPPRDSPPLPMMEDMREVEAYAMSGPQHYSLQQRPSPSHSQDVKSMAARPHQAPNAAPQMQLPPVPYTQGSSDYQSQPMIRTVSEQHQPPLYGEWAPPVAAANTRAVDEGILHPDETWERTSDARDKPPPAAPELDEWDFSDGAFSEPGATQQQQQQQQQAVASLSSNRPDTDVFPNAEHLPKSPGRALGGHRRKSSLSRRRSAENELSLNASQRAEGGTFKLRFGLRGHLNTVRTVIFSGGGSPGEPEICTAGDDGMIKRFHIPRLDGSLGNAASDLDVIANFTHRGHGGSVLSLTSWSPSPNFSTGGRARGDGWIFSGGQDATIRVWERGRVDPKATLEGHTDSVWALCVLPTTLGAVFGASSPYGSTDRILLVSGAADSSVRLWSVSAPPQLSSPQPGTNRSMSGRGGRVRGNSMSSGSGFPSAPQATMASNSPFHHTLVHIISRSDGSKATPTCIAPLGGSGETFVVSYSDAAVIVYDTRTGEQVGQMDSLETYNGTAATSVNAVVATTSGLDQGGQHHGSNGDDPGGPTGGRSMAGSGVEGTIISGHEDHYVRFFDANSGQCTYNMMAHPDAISSLSLSPDGRELVSAGHDASLRFWSLEKRTCTQEITNHRVMRGEGVCSCVWSQDGKWVVSGGGDGVVKVFAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LS44</accession>
    <name>A0A367LS44_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Elongin-C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_2448</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Controls sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LS44"/>
    <dbReference type="STRING" id="1330021.A0A367LS44"/>
    <dbReference type="OrthoDB" id="249087at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18321">
        <property type="entry name" value="BTB_POZ_EloC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000035">
        <property type="entry name" value="Elongin C transcription elongation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039948">
        <property type="entry name" value="ELC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20648">
        <property type="entry name" value="ELONGIN-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="6">
        <location>
            <begin position="9"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI17229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="110" mass="12562" checksum="7A3F3C36AF441D96" modified="2018-11-07" version="1">MQTPEISKYVTLVSADGFEFVVLREAALVSPIIKGMLDPRSQFSEAQNARCVFQEMSAAVLDKVVEYFHYWYRYRTSEDVPDMEIPVELCLELLAAADYLGLDQANMNMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LSF1</accession>
    <name>A0A367LSF1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Heat-labile enterotoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_2516</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LSF1"/>
    <dbReference type="OrthoDB" id="4925061at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.210.10">
        <property type="entry name" value="Heat-Labile Enterotoxin, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001144">
        <property type="entry name" value="Enterotoxin_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01375">
        <property type="entry name" value="Enterotoxin_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00771">
        <property type="entry name" value="ENTEROTOXINA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0800">Toxin</keyword>
    <keyword evidence="3" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016844941" evidence="5">
        <location>
            <begin position="25"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI17341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="385" mass="43295" checksum="C1C4E0F6EAAA0B1C" modified="2018-11-07" version="1">MLGQPTLILLCFTLASSWPQLVWGGDPWDSSTLPFGDGIVYRGDSITPDQLRKRDGFWPKGLTPGRQAFPLAANISLFRHTEESIEVNNRDSWGFIQTSSRYELALNWINVRDLVPGYVYAIHATPNFVNVKASLLQYQYDKNRGDDAYAALGSIPYNQIMAWRRVDVDASQPGVPRVGPVEMNPLYDEAAYGGETWGGAQYDLAGFPDATYEPVAKGLKPWCHTDGCNSRATRAAAQKLLGSRVRVHSLSLHCHLSHDLLSGTNDVILMRIGQSRPITVFKLPGRGAVRNLDVNLDHYFDDGEDLRLSNLTSIRVLHRRGYRIWADAFKIEGIRLEAKTSSSRKTLEMNKFKNMDTWMGTKAAGTTLVWRKGFSLDDWTYVDYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZE0</accession>
    <name>A0A367KZE0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L249_1589</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the fungal Na(+)/H(+) exchanger family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000026">
        <property type="protein sequence ID" value="RCI07534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZE0"/>
    <dbReference type="STRING" id="1330021.A0A367KZE0"/>
    <dbReference type="OrthoDB" id="2190219at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120029">
        <property type="term" value="P:proton export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042391">
        <property type="term" value="P:regulation of membrane potential"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036376">
        <property type="term" value="P:sodium ion export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1530.20:FF:000015">
        <property type="entry name" value="Na(+)/H(+) antiporter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013928">
        <property type="entry name" value="Cation/H_antiporter_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004712">
        <property type="entry name" value="Na+/H+_antiporter_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382">
        <property type="entry name" value="NA(+)/H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31382:SF4">
        <property type="entry name" value="NA(+)_H(+) ANTIPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08619">
        <property type="entry name" value="Nha1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0050">Antiport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0915">Sodium</keyword>
    <keyword evidence="10" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="245"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="361"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="406"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="13">
        <location>
            <begin position="28"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Alkali metal cation/H+ antiporter Nha1 C-terminal" evidence="14">
        <location>
            <begin position="458"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="465"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="676"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="744"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="831"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="465"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="511"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="577"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="850"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="862"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="926"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="956"/>
            <end position="965"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCI07534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="972" mass="106579" checksum="FABAC97777121D7C" modified="2018-11-07" version="1">MAWSHLDITEPHLVYIILGGFTSLFMLSSSFIKERMYIGEATVATLCGVIFGPHAANLIDPDKWGSVDIVTLEFSRIVLVVQCFAVGVELPKFYMEKHWRSVVLLLIPVMTFGWLIVSLFIWWMIPALDWLDSLVVAACVTATDPVLASSVVGKGKFAKRVPKHLRDLLSAESGCNDGMAFPFIYLSLYLIQYDKNAAKVSYYFIVYVILYECIFGAVFGFLIGYIARHGIKFSEKHDLIDRESFLVFYFALALFCAGSGSILGLDDLLVGFTAGVGFSNDGWFGEKTEESHVSNVIDLLLNLTYFVYFGTIIPWEQYNNGVFGVRAWRLVVIAIFVLLFRRIPIMLALKPLIPDVKNWREALFAGHFGPIGVGAIFVAILARAELEHHESVPLPDPPSEDLENYALIYLVWPIVTFLVISSILVHGSSVAVFTLGKRINTLTLTMSYTAAPDEGAGWMNRLPRISSQSRSQAKTMSDASFDDDKEPELPPGTLLPPLGFLRRQREDDNPSRTGSRASSLVSRRRKHSRRWDDGIGPGGPVSQSAIFPTRPTPGAVTPLHEASPRENTESTLSGGSPKEDEPERPEEVAAGGGEASQQPPRLNVYAEGDHLVVEDQDGDVLHVRSAHPPSEDGTRQSSASPSGADDDSVAGPSSGQRPVWTLNGLRRKVNEVYTSELEKRKGKGKVQRRHEPARAYQFGNTIIVEDEDGEVVKTYEVPSPRDQGGNNSSDLIGTSLKYLGLGNKARQGQKSAEATAEEGEAGRPSGWPTFGRAGTQKKTVAKQQQEADDDKKIRFTIGGVGQRMTKDDFIRQVQNLDARTRKVVVDESTASTAVKRLARQGPPQQPGEPSSRRDPEERSGQRARPPAKAVTAAAAATTKTTTDSGGLLSVDETPVERRRRLAVLSTQADEADDTGETPAERRRRQAALGMEGAAAGEDSDDDEGTERVPPVRRGIRFAEPKRNERAAGGASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZV8</accession>
    <name>A0A367KZV8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Benzoylformate decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_5716</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000024">
        <property type="protein sequence ID" value="RCI07708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZV8"/>
    <dbReference type="STRING" id="1330021.A0A367KZV8"/>
    <dbReference type="OrthoDB" id="19714at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034715">
        <property type="term" value="C:pICln-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039924">
        <property type="entry name" value="ICln/Lot5/Saf5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21399">
        <property type="entry name" value="CHLORIDE CONDUCTANCE REGULATORY PROTEIN ICLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21399:SF0">
        <property type="entry name" value="METHYLOSOME SUBUNIT PICLN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03517">
        <property type="entry name" value="Voldacs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="225"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="225"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI07708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="29492" checksum="75AA06B768502A9A" modified="2018-11-07" version="1">MHASTLRATTTIRVPPSVDNYVSLAQYQAQTPESFAVGRAVLHFHLEGATASIPEEQRGKLALFPADMNPDSHGQTLERKVDVFVNSEDFTVFSPEAHVGFSIPYYSISIHAIKHVNGQNAIWMQLELDDGGAHDDDFSTVELTLFPGERETVKQLFDAVSACSNLHPDPEDDSDEENGYTIEDYDGANDVAVFTGLDADGNMPASVPGSGGWITAENAHNFFDDEGNWIGENDDDDLGEGAGRVRPHSEVNGDGLNGADDDNKRPRVDEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZW7</accession>
    <name>A0A367KZW7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5711</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000024">
        <property type="protein sequence ID" value="RCI07711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZW7"/>
    <dbReference type="STRING" id="1330021.A0A367KZW7"/>
    <dbReference type="OrthoDB" id="5221663at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016834903" evidence="1">
        <location>
            <begin position="20"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI07711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="329" mass="36318" checksum="BBD1F0C192F42278" modified="2018-11-07" version="1">MADSVGSLLAAIALLLADGLRILDLADKRHWGADEHEQRRALDEALDEARKDFQELAPLVHGQAHYELDRRHESLQELRMLRSRCRDLVFALKDWTRCGGPINPVWVVHTHSLQRDLHRAQCRAARRIFTSDRESSARCLGAFLLLRRGRTAAGVEAVGTFERFSDEDVVFVCDFCDGHLVWHDVEAVPLLKTATTTTTSGSPTSISTTTTTTTTTTTNVTTAIPPLPFWQTPALSTSSATPKTVISPLVAIANHVPPPLGDWLAPLLCPYCEDEARRPHDDDDDDEADAYRAVSIDEFDDLEALQLHFEAYHPASSPVDAGGSSCLVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L006</accession>
    <name>A0A367L006_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5769</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000024">
        <property type="protein sequence ID" value="RCI07737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L006"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI07737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="82" mass="9395" checksum="021109C6D4BB93AD" modified="2018-11-07" version="1">MLTRRLINRTLIYRKFDCLDRPPFLGSLTYPTFLPSRAVAVAASYVVVLFLPLLCDVRRPRVGCSRPGVTVWRSRQSTRNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L098</accession>
    <name>A0A367L098_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_5800</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000023">
        <property type="protein sequence ID" value="RCI07855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367L098"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000393">
        <property type="term" value="P:spliceosomal conformational changes to generate catalytic conformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18019">
        <property type="entry name" value="DEXHc_Brr2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18021">
        <property type="entry name" value="DEXHc_Brr2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000005">
        <property type="entry name" value="Pre-mRNA splicing helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000133">
        <property type="entry name" value="Pre-mRNA splicing helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000004">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000102">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000368">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein 200 kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000024">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000004">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000001">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000062">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000254">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041094">
        <property type="entry name" value="Brr2_helicase_PWI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048863">
        <property type="entry name" value="BRR2_plug"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21188">
        <property type="entry name" value="BRR2_plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18149">
        <property type="entry name" value="Helicase_PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039073">
        <property type="entry name" value="BRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="534"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="756"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="1385"/>
            <end position="1561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="57"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="240"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2191"/>
            <end position="2228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="240"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="2193"/>
            <end position="2215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="2216"/>
            <end position="2228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI07855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="2228" mass="252148" checksum="A0FD67DD9F7E77C4" modified="2018-11-07" version="1">MSDQHRDVSQYKYSAMSNLVLQADRRFVTRRNDEATGDPESLAGRLSIKDMGNRVARDEVPKQKKQPGLPDIQRGSLQEGGDVLKREQRKAKTEASQQMGTGLLGANDALIEGITYRPRTAATRATFNLILTSVAASLGDVPYEVVRSATDAVLEYLKDDELKDVDKKAEIDDILGTALSPKKFIELVNLGKKITDYDTQDDEDPDVSGQVGETEIDERQGVAVTFDDDQDENDVVEEVNEELSEDDVSEEDEDENRNAAENDEVVFDNEELALDTNAPGAKNKKDESHSVPARDIDAFWLQRQIGTLYPDPHEQTDKTKTALRLLSGETDASGGEEERTLREIENDLMELFDFEHHELVQKLVENREKVYWLTRLARAETAEQRTGVEREIVSEGLHWILNELRGEDTGDDEKRRKLSMKMDIDVPASMVAEKPEPVRPEGHLVGGLKPKRLIQLDNLVFDQGNHFMSNPKVRLPEGSTKRAFKGYEEIHVPPPKKRNDPGDTLIPISDLPEWARGPFSSANSLNKIQSKCFPSAFEGGDNMLVCAPTGSGKTNVAMLTILRELGRNRDQSTGEVDLDAFKIVYIAPLKALVQEQVGNFGKRLEQYGVRVSELTGDRQLTKQQISETQVIVTTPEKWDVITRKANDLTYTNLVRLIIIDEIHLLHDDRGPVLESIVSRTIRRTEQTGEPVRLIGLSATLPNYRDVASFLRVDTNKDLFHFDSTFRPCPLRQEFVGVTDRKPIKQLKTMNDVTYNKVVEHVATNKNQVLIFVHSRKETAKTARYIRDKAIELDTLNRILRLDAASRELLQEASSQAKNEDLKDILPHGFGIHHAGMNRIDRTDVEDLFSRGAIKVLVCTATLAWGVNLPAHTVIIKGTQIYSPEKGAWVELSPQDVLQMLGRAGRPQFDTYGEGIIITTQSEIQYYLSLLNQQLPIESQFVGKLVDNLNAEIVLGNVRTRDEGVEWLGYTYLFVRMLRSPGLYQVGAEYEDDEALEQKRVDLIHSAAMVLRQSNLIKYDEKTGRLQSTELGRIASHYYITHGSMNTYNNLIQPSINTIELFRIFALSAEFKYIPVRQDEKVELARLLGTVPIPIKESVEESHAKINVLLQAYISQLSLSGLALMSDMVYVTQSAGRILRAIFEICLKKGWASVAKIALNMCKTVEKRMWPTMSPLRQFPTCPRDIITKAEKMDVPWSSYFDLDPPRMGELLNMPRAGRTVCGLVARFPRLEVRAQAQTMTRSMLRVELSIIPNFEWDDGVHGAAQNYWIIVEDCDGEDILFHDTFLLRKTYAEAESNEHIVDFTVPITEPMPPNYFVSVISDRWMNCETRFAIPFQKLILPDKFPPHTELLDLQPLHVAALKLESYVDLYPGWKQFNKIQTQTFNSLYKGDQNVFVGAPTGSGKTVCAEFALLRHWLQEDPGRAVYIAPLQELVDSRLQDWQKRLSGLGGGKEIVKLTGETTTDLKLLERGDLILATPVQWDVLSRQWKRRKNVQTVQLFIADDIHLVGGNMGYVYEIVVSRMHYIRTQTELPMRIIALSVSLANARDVGEWIDAKKHEIYNFAPHVRPVPLELHIQSYSNPHFPSLMLSMAKPAYLAITQMSPDKPAIIFVPNRKQTRATTRDLMAACAVDGDEDRFLHAEVEQMRPLLDRIHEEALAEALSHGIGYYHEALSQSDRRIVKHLYDNGAIQVLVASRDVCWELTSTAHLVVVMGTQFFDGREHRYVDYPLSEVLQMFGKSLRPSKDGRSRGVLMLPQVKRDYYRKFLNEALPVESHLHHFLQDAFVTEISTKMIESGDDAINWTTFTYFYRRLLANPSYYDLQSTTHEELSNFMSDLVERTLRELGESKIIEFDEDDGTVAPQNAAMIATYYNISYVTMQTLLMSLNGRTRLKGILEIVASAAEFESIQVRRHEGGLLRRIYDRVPVKMSQPSYDSPYFKAFVLLQAHFARMQLPIDLAKDQETILCRVLGLLSATVDVLSSEGHLNAMNAMEMSQMVVQAMWDRDSPLKQIPHFGPDVVKVANGFGIKDIYGFMEGMNPDDNPDYDKLVNGLGLSQAQLAQAAKFINDVYPDLELEHEVLDEDEIRAGEPAYLSIKVKRIVEDGEGANYDATVHAPFFPVKKTENWWLVVGDAKSQNLLAIKRVTIGRELSMRLEYTVPAAGEHKLRLYLMSDSYVGVDQEREFVVKAVEGMEVDDDDADDDDDDDDDDVDEDEAGGKDGHENGDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0I5</accession>
    <name>A0A367L0I5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5764</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000024">
        <property type="protein sequence ID" value="RCI07732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0I5"/>
    <dbReference type="OrthoDB" id="3436397at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI07732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="98" mass="10679" checksum="75E4DAC938AEFB10" modified="2018-11-07" version="1">MAQDSPSSGGNDESFKEQLDRQATQERGAPQAPDTVTAKITEYIPAAAKLFGNQQQEQEQAAAPAKALSGPPNRPTHDDKIEDFVRDQHRSKDGMESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0K3</accession>
    <name>A0A367L0K3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cyclic nucleotide-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_7857</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000022">
        <property type="protein sequence ID" value="RCI07960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367L0K3"/>
    <dbReference type="OrthoDB" id="421226at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005221">
        <property type="term" value="F:intracellularly cyclic nucleotide-activated monoatomic cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000057">
        <property type="entry name" value="Cyclic nucleotide-binding domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050866">
        <property type="entry name" value="CNG_cation_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638:SF24">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G03170)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45638">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16643">
        <property type="entry name" value="cNMPbd_u2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1071">Ligand-gated ion channel</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1109"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1148"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1179"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1210"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1239"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1269"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1300"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="11">
        <location>
            <begin position="72"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="11">
        <location>
            <begin position="281"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="F-box" evidence="12">
        <location>
            <begin position="584"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="425"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="534"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="740"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="461"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="474"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="764"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI07960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1365" mass="148057" checksum="6EAD1573C7118E40" modified="2018-11-07" version="1">MRRGRPAGVASPYRALAHHHHHQQQVPSDSTLIRSFDVEANPARPVRPSPLATSVIRDMPLDLVDRIRSFPLFQSAPGEFLIAIGNHLKPQIHVPNDHVVTEGDDAKAMYWLVRGVVAVISRDGEAVYAELQAGAFFGEIGVLMNMPRTATIVARTKCLLLVLKKEDLQLVLPRFPDMERAILEEAQERLNLLKKKRIEKSAGVVQFSEQRWSGGEAAIATAATGGASAGESGAIMDGAVVKNPKKRKSPSPGIIEDLASGGSAIGSGLVNIRKTLKELPLFSTLPPDILHFLGLSVAPKTFPPFTDVIRQGSSGNEIYFIVQGEAEVVHRDQPTSPPDDASAIGQFQQRPRLKAGQYFGEVASLGLSAGRTATVRSITTVECLVVPGETLEELWRRCPPSIRTQVEKTARERYSEVRRTNSPWDVDMADLGRTDTASNAPKTPPKTPSPATSRGYVAASIFTTPSRNETSPTGKDDKTEMMSLKDPDPFRSVDMENLRNRRRQSLVSPSTAPLLAEAAVATTCGRSKGISRPRLFTEVTPPPVKPESPTEVGSAVRAKRSRTLPSQRPVTAEAHDVEAFTAPPAVVAARSDDILVRIFKHLDVGDLVRLRIVSRHWRLILETSPVVCNDVDLSRYSRRVDDDVIVSVLAPFINTRAVSVDLNGCFHITDRGFSALWSSCGKNVTRWRMRSVWDVSATQILEMSENAKSLEELDWSNCRKVGDNLLARVVGWVIPAKKGDVAQTPSSSACDNKKRSKGMNRNSKASDGDDETRNGHGGPEASCGSSTIIGCPRLSKLDLSYCKHVTDRSMAHLAAHASNRLSWLSLTRCTSITDAGFQAWARHKFERLTYLCLADCTYLSDSAIVALVGAAKQLTHLDLSFCCALSDTSTEVVALGLPRLRELRLAFCGSAVSDGSLQSIGLHLCQLEGLSVRGCVRVTGRGLESVLEGCARLGWVDVSQCRHLEDWFRSGNVAKWGFDDRAKKPPPQAAAVPCGLGGPGVMSIPTALPNPSVATMLATPGILPRSHLGGFFPGRRTKRQPGPARFAQLSKTAVRSFQKPSSTGILRPRIAPQAASRNAFSRSIGQRSYYNESLSQKQSMTSGPGMRKLMVGGAIFGGTLLAVNFVFNRETRDDGGMPDYEREYLNSTFLHTGLGIGIIGLTARQMVRTGFVYRLMVTSPWVVGIGGLALSFATMIGTRSISPDNYIPKYALWTAFNATQAAFVAPLLAFVPMPLLARAGLYTAGVVGALSLVGATAKQEKYLYIGGPLLAGAAVVALSGLAPLALPATAVRTLAFTEKMWLYGGLAVFGGFTLYDVQKILYHARLAEAGMMKRDAVNESIGLELDFLNIFVRLVQIMMMNQSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0K8</accession>
    <name>A0A367L0K8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">116 kDa U5 small nuclear ribonucleoprotein component</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">U5 snRNP-specific protein, 116 kDa</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_7870</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Required for pre-mRNA splicing as component of the spliceosome, including pre-catalytic, catalytic and post-catalytic spliceosomal complexes. Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. As a component of the minor spliceosome, involved in the splicing of U12-type introns in pre-mRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000022">
        <property type="protein sequence ID" value="RCI07973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367L0K8"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04098">
        <property type="entry name" value="eEF2_C_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04090">
        <property type="entry name" value="EF2_II_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01683">
        <property type="entry name" value="EF2_IV_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16264">
        <property type="entry name" value="snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04167">
        <property type="entry name" value="Snu114p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000004">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000029">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000009">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1430.10:FF:000001">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001452">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2300">
        <property type="entry name" value="Neutral/alkaline non-lysosomal ceramidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1430.10">
        <property type="entry name" value="Yeast translation eEF2 (G' domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031950">
        <property type="entry name" value="EFTUD2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038445">
        <property type="entry name" value="NCDase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031331">
        <property type="entry name" value="NEUT/ALK_ceramidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031329">
        <property type="entry name" value="NEUT/ALK_ceramidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044121">
        <property type="entry name" value="Snu114_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035655">
        <property type="entry name" value="U5-116kDa_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF6">
        <property type="entry name" value="116 KDA U5 SMALL NUCLEAR RIBONUCLEOPROTEIN COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04734">
        <property type="entry name" value="Ceramidase_alk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17048">
        <property type="entry name" value="Ceramidse_alk_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16004">
        <property type="entry name" value="EFTUD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016861082" description="116 kDa U5 small nuclear ribonucleoprotein component" evidence="12">
        <location>
            <begin position="31"/>
            <end position="1896"/>
        </location>
    </feature>
    <feature type="domain" description="Tr-type G" evidence="13">
        <location>
            <begin position="1042"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="35"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="890"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="928"/>
            <end position="951"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00045974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI07973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1896" mass="210426" checksum="B49ECD229D66C92B" modified="2018-11-07" version="1">MVFLRPASTTLRPRSLAKLILLVFLGDAYARSRGVPQDGDAPSALSLDLGNPPQPIRQSDADFGQLPSPVTQKPPFLGGSADVVFGEQQELTSPNESPMQVEPGIDGKQAGSQGPTDFPDRTDGPKGRPQNSRPFERPRGPKSQGPIDFPDRTDGPKGRPQSSRPFERPREPKGQSPIDFPDSTDGPKGRPQSSRPFERPREPKGQGPRLSKDSKFLIGVGKADITGPVVELVMAGYAHSDQVATGLRQRLYSRAFIIADAKDPRNRLLYVVLDNINSDASIRMSILDAFKAIPNGDLSVYNEHNFALSSVHSHSGPSYGWNYFLAQVPQSGFDMQGHRAIVDGALLSIKRAHMSLEEGHLDFATIEIEDASINRSKWAYLANPEEERDKYARDVDTTMTALRFRRASDGRTRGLLTWFPVHGTSLYGNNTHVSGDNKGLASWILEQKMRKLAPFTDDFVGAFGQANEADVSPNIGGAWCEDGSGQPCNMTDSSCPDGKVTKCLGRGPMFRALDLGVSSCHEIARRQAAKAEELMVSGEILDVLLMCLTAVSSCYHFYHDMAWWNFTTTEGNKVMTCPAALGYSFAAGTTDGPGLFDFVQGDADKPRNPIWTFTFGVVKSPTRRQKICQVPKPVLFDGGETQYPYEWSPNIVDVAMFRIGQLFIILSPSEVTTMGGRRWRKAVGQEAETFMKPVRPIVVLAGPVNSYSHYLTTKEEYDIQRYEGASTLFGRWQLDAYMNLSVSSMHYLTPGSKDYPEQGKMPPDNRKRSFNANPGIAIDLAFRSSSYGEPVHQPDPQYVVGKDVQATFKGANPRNNLRLEDTYAAVEQLGSDGNWTRIRDDEDWFLVFTWRRNGYFFNRGEEVDITWETKGNAQPGTYRLKYYGDAKTATQVEPSVEDSSHLHTPPSTLPDPSTMEKSYDEFGNFLGEESDEASDASVDEADDDIDDDEQNEAQATSNLQLMEVDEGPSNAVVLHEDKQYYPTAQQVYGPDVDTRVEEEDALPLTKPIIAPVEVKKFKIEEADLPPVFFDRTFMSDLMNFPEQARNVALAGHLHHGKTSFMDMLVMETHDISERLNKRTGRKRDERLRYTDVHLMERERGISIKAAPMSLVLQNTRGKSHLINIIDTPGHVNFVDEIAASFRLVDGLCLVVDVVEGVQINTEQIIRHAVLEGLPMTLIINKMDRLILELRLPPKDAYFKLKHVIEEVNTAIANTVPGAKAVLNRVSPELGNVLFACTDLGWCFTLQSFAQMYSEKYGEVNAQDLAKRLWGDVYYNPEKRNFTRKPLESATPRSFVHFILEPIYKIFTHSITDSPVNLKKVLTSLGIELKPKQYKADAGVILKLVCQQFFGPCQCFVDMILQHVPSPGRGAQRLLEHHYTGPLDTKIVASMRSCDQDGPLMVHVTKLFSTTDAKSFLSLGRVLSGTARPGMAVRVLGEGYSADDEEDMTTAEIGQVLIAETRYNIVTDGVPAGSLVLLSGVDNSIVKSATIVGSNLGGEDAHIFRPVIHFTQSVLKVAVEPVNPSELPKMLDGLRKVQKSYPLIDTKVEESGEHIIMGTGELYMDCVLHDLRRLYADMDIKVSDPVTCFCETVVETSATKCYAITPNKKNRITMVAEQLDKGIATDIEAGVVKIRDPVRKTARYFEENHGWDKLAARSIWAFGPDEKGPNVLQDDTLPTEVDKKLLGTVRESIRQGFSWAAREGPLCEEPIRNTRFKVTDVVLANEAIYRGGGQVIPTSRRACYSSFLMASPRLMEPMYAVSVTGPEDSYMEAYNVLSRRRGHVVSDGPVAGTPLYRVNGLLPVIDSLGFETDLRIKTQGSSMVSMVFDGWNIVPGDPLDSEVTLRPLQPASTQATARDFMLKTRRRKGLSEDVSVKTFLEPEFYESLMASGLLGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1A4</accession>
    <name>A0A367L1A4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial import receptor subunit tom70</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_6346</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Tom70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1A4"/>
    <dbReference type="STRING" id="1330021.A0A367L1A4"/>
    <dbReference type="OrthoDB" id="2942533at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005687">
        <property type="entry name" value="Tom70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00990">
        <property type="entry name" value="3a0801s09"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46208">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46208:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 10" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="340"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="408"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="476"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI08205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="629" mass="69052" checksum="689BF39A824591A9" modified="2018-11-07" version="1">MASPAPSMPPGPTPGIGLEPPPSAWDRLALWVSENKVVVYTIAGVAVVVTGAGAFYYLGSDASKTDASPKLSKKERRKRKEVERKAAETASTATQFTAAATAAAASAASVESDSELPEVDATSVTSLTQQERDAYAAKLKQAGNKAYGDKAYNRAIDLYSRAILCKPDPVFYSNRAACYSAMSEWDKVVEDTTAAINMDPYYVKAINRRATAYEHQKKYADALLDFTASCIIDNFKTDSTAQAVERLLKIIAEQRAKEMMASRPPKLPSPVFVGNYLQSFRQKPRPARLADTVDLDPDQGPGQLQLGLRCLEKKTADGYEEARLAFEKAIELGGLGEHEALALNLRGTMRTLVGNSADAMVDFERSIQLDPGMIQSYIKRASISLELGELAKADAEFSQAIAQNSNDPDLFYHRAQANFIKGDLSEAQKDYQKSIDLDKDFIYSHIQLGVTQYKMGSIASSMATFRRCIKNFPKVPDVYNYYGELLLDQGNFVEAIEKFDTAMELEKQSKPMAINVLPLINKSLALFHWKQDFDEPQKLCQKALIIDPDCDIAVATMAQLLLQQNNVAEAVKYFERAADLARTEGEVINALSYAEATRTQVQVTDKYPKLAAKLAGGNAAPPGFRMGPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L201</accession>
    <name>A0A367L201_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CDC45-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_8930</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC45 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L201"/>
    <dbReference type="STRING" id="1330021.A0A367L201"/>
    <dbReference type="OrthoDB" id="10258882at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902977">
        <property type="term" value="P:mitotic DNA replication preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003874">
        <property type="entry name" value="CDC45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507">
        <property type="entry name" value="CDC45-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507:SF0">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 45 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02724">
        <property type="entry name" value="CDC45"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="201"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="403"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="709"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="235"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="720"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="768"/>
            <end position="810"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI08451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="867" mass="95957" checksum="4A88B19037A438D4" modified="2018-11-07" version="1">MYLPRSLISKLYAHLQNTRHPLSPPVLILVALEPDALCACRILTRLLKHDYIPHKIQPIAGYGDLETAGRELVVPMMESRGGSGGVVVCLGVGGMVDLGPLMGLESEDQEHPYSGVEVWVVDAHRPWNLGNVFGGFPLQPQTETSASFQARSPLGVEGGRIGRHYKATGGGIIVFDDGDIEEDLQAEQEAYLALVDMPDIDEDDEDAGEEDDQDQDSPDQGEARPGQKRKSWSDGNEDDSSDDEDDRPPHQRRRSNSSSSIPAEHRPRGLLSLRDPDAGLFSDSAEPSAPVPSARSLKRKLIRMRAQHEAVLQKYYKLGTSFAEPISSMMYSLASELGREDNDVLWLTIVGVTSMEIYGRSSSGIAAPVRGTDRGRPTGWMGVRGARLRQLLRDEVRRLNPPELTNGRVVPENTGLIPTTARNPEDTGIRLSPEPRFLLIRHWSLYDSMLHSPYLFSRLKTWSESGLKRLHKLLAKMGVSLAQCKQSYVHMDMMLKRDLRAKLLKYGSLYNLGEMVPAVDTDGKDRGGARDGWGFVRSWGWRATLSAQDVGVVIGALLEVGRQTPAADGRYRASREADGQVDDESARGEEEWVVRFWEAYDALENIEALKAGLPTAQFMYRAIYRTGTSLINKKQIKHLRAFRMCVVKDGPDVALFTHPAALTKLALWVGEALTEQERESHGKLSHGGRGTPLVVASLNERRGVYVVVGTGGGGGPDTSFVDREAAKKRREEKEARARVKEEARKARKDKIRAEKRAARRARGKEDDYGGDGDGDDNDDDDEEDEDEDEDEDEDDDATESSSSEDESDAGDGERGYGRNRFGNAFQEVVAETKARVRIDSFDNCVVEVKKEDLGAFLESLSMKVVVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L217</accession>
    <name>A0A367L217_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chitobiosyldiphosphodolichol beta-mannosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.142</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_8880</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.142" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L217"/>
    <dbReference type="STRING" id="1330021.A0A367L217"/>
    <dbReference type="OrthoDB" id="614844at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004578">
        <property type="term" value="F:chitobiosyldiphosphodolichol beta-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026051">
        <property type="entry name" value="ALG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036">
        <property type="entry name" value="BETA1,4 MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036:SF0">
        <property type="entry name" value="CHITOBIOSYLDIPHOSPHODOLICHOL BETA-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13692">
        <property type="entry name" value="Glyco_trans_1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI08447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="469" mass="51616" checksum="2307A1E41242D0A4" modified="2018-11-07" version="1">MAPLPFLTLPLLASIVVGALLTLAFGYALGLLFRLAPSRYRPAAAAVAAAQPDHVQVLVLGDIGRSPRMQYHALSAAKHGYHVDIVAYKETARHPALIGNAHVSMYALAPQPEWIAWGTLPFFLNLPAKVIHQFCTLFYTLLYRTPPARCIIIQNPPSIPTFHVALLVALLRRSNLLIDWHNYGYSILAQKPLYRPLVPLYRWYELGLGRFLGHANLTVTHAMARQLRCHIKGPVHTLHDRPAETFRPEPSPEHRLAFLSHLPETKSQARDIVDGNVRLIVSSTSWTPDEDFGILLDALASYANPQSGSTAEPPMPILAIITGKGPEREAYLERIRRLVDDGRLPGIRILTAWLSTGDYASLLASADLGVSLHKSSSGVDLPMKIVDMFGAGLPVAAYSAFESFGELVKEGDNGCGFETSGQLADIFRRLLSTAGQRELAALRQGAVREGALRWDDEWDRVVAPLLESM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2F9</accession>
    <name>A0A367L2F9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4867</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2F9"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="65" mass="7231" checksum="8664FED472D75DB1" modified="2018-11-07" version="1">MPSPRSASRRRPLARPKRGSRSSLRSTTSRRRKRAISRRLGVSSASRLKGRSMACCLLTMSSLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2Z5</accession>
    <name>A0A367L2Z5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L249_4869</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the RBR family. RNF14 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2Z5"/>
    <dbReference type="STRING" id="1330021.A0A367L2Z5"/>
    <dbReference type="OrthoDB" id="1431934at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20354">
        <property type="entry name" value="Rcat_RBR_RNF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23820">
        <property type="entry name" value="RWD_RNF14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000416">
        <property type="entry name" value="RBR-type E3 ubiquitin transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047548">
        <property type="entry name" value="Rcat_RBR_RNF14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22191">
        <property type="entry name" value="IBR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RWD" evidence="14">
        <location>
            <begin position="14"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="178"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="182"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="301"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="489"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="489"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="530"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="568"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="602"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCI08803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="668" mass="73636" checksum="3D5C160330994094" modified="2018-11-07" version="1">MERAPVDVDDPRSVELETLTAIYPEIRTLDGSPYTFELDLPVQPAQPVTVYFEALDELEAADQEPVDSILVSHLPWLRLCLSLPEGYPSSKPPLISLSTTPQWISRQRLAALESDVLKLWEEAGGDLVAYTYIDHIQRAAEDVFGAVSAQGILRIDSAHRLAVLDHDSKAKRAVFEKETWDCRVCLDPKRGLLCHQMLDCDHVFCLDCLKDFYRDAIEQGNLRSVRCLDPNCAKERASAAESRRKAKSFISPSELLQIGLCEDVVKRYVMLRYKTELESDKDTVYCPRRWCNGAARSKRHKKPEGLEFGETSDVEPDEQDGDDDDGDDDAAGSGQASKFKTVDLLCVCEDCGFAFCSRCLQTWHGEFVRCAPKRNKDEVTEEDKASLEYMQLHTSPCPTCNAPAQKTHGCNHMICSRCETHFCYLCSSWLDPGNPYRHYNQQSDGKVTSCYMRLWELENGDGDDVGLGFEGGRAANGELRPYLEQFVDGAEEEEEEDDDDDDDDDEESESEDEAENGHINNDGGPIPRRRPLEPVDARPRPARQRGEAGGRRPQRGARGRGAERGRRQAPAPAPAVAAVMVGGRGRGGNLWPRGRGRRRGDGGGGGGGGGGGGGGGGGQGVGHDGGQQEGENMGNGMNAVEAAWVRNFVRLALADAEDQLDDEELVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L326</accession>
    <name>A0A367L326_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2-isopropylmalate synthase</fullName>
            <ecNumber evidence="7">2.3.3.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L249_4670</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21524"/>
            <dbReference type="ChEBI" id="CHEBI:1178"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.13" evidence="7"/>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L326"/>
    <dbReference type="STRING" id="1330021.A0A367L326"/>
    <dbReference type="OrthoDB" id="418791at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003852">
        <property type="term" value="F:2-isopropylmalate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009098">
        <property type="term" value="P:L-leucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07942">
        <property type="entry name" value="DRE_TIM_LeuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000045">
        <property type="entry name" value="2-isopropylmalate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.270:FF:000002">
        <property type="entry name" value="2-isopropylmalate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00572">
        <property type="entry name" value="LeuA_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013709">
        <property type="entry name" value="2-isopropylmalate_synth_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002034">
        <property type="entry name" value="AIPM/Hcit_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005668">
        <property type="entry name" value="IPM_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054692">
        <property type="entry name" value="LeuA-like_post-cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036230">
        <property type="entry name" value="LeuA_allosteric_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039371">
        <property type="entry name" value="LeuA_N_DRE-TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00970">
        <property type="entry name" value="leuA_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002991">
        <property type="entry name" value="PRK03739.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46911:SF1">
        <property type="entry name" value="2-ISOPROPYLMALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22615">
        <property type="entry name" value="IPMS_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08502">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00917">
        <property type="entry name" value="LeuA_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110921">
        <property type="entry name" value="2-isopropylmalate synthase LeuA, allosteric (dimerisation) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89000">
        <property type="entry name" value="post-HMGL domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00816">
        <property type="entry name" value="AIPM_HOMOCIT_SYNTH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0432">Leucine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="14">
        <location>
            <begin position="35"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCI08807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="588" mass="65694" checksum="41833524B22B3CFB" modified="2018-11-07" version="1">MAGRRLKEPWKKYKKFPPINLPDRQWPSKTLDKPPRWLATDLRDGNQSLTGDEKWRYFKMLVDLGYKEIEVSFPSASDTDFDFTRRLIDTPGTVPDDVWMQVLSPCRPDLIRKTVESVKGAKKAIIHIYLASSECFRRIVFNFTKEESLQTAVNCAKLVRSLTKDDASQQGTEWAFEFSPETFSDTEPEFVIELCEAVKAAWEPSVENPIIFNLPATVEMSTPNVYADQIEYFCRNITERDKICVSLHPHNDRGCAVAAAELAQMAGADRVEGCLFGNGERTGNVDLVTLGLNLYTQGIHPNVDFSDLESVIETVETCNKIPVHERAPYGGALVVCAFSGSHQDAIKKGFQLREREGLTYDDRWQIPYLPLDPQDIGRTYEAVIRVNSQSGKGGAAWIILRQLQLDLPRGLQVAFSRIVQRRADELGRELRPKEITELFEETYFVKDNPRFTIVDYSIQPDRGASPGPPALGKTQDTKDMKRVFEGVISCNGTEHQLRGRGNGPISSLASALRSVGINLDVQDYKEHAIGRGRQAKAASYIECTAAGSDQRVWGVGIHQDVVQSSLTALLSAASNVSDGIKLESRSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3B7</accession>
    <name>A0A367L3B7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipase/carboxylesterase/thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_4833</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3B7"/>
    <dbReference type="STRING" id="1330021.A0A367L3B7"/>
    <dbReference type="OrthoDB" id="437457at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF67">
        <property type="entry name" value="PHOSPHOLIPASE_CARBOXYLESTERASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_5G09340)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="2">
        <location>
            <begin position="26"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI08702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="243" mass="26050" checksum="4AF23D8E066F1A9C" modified="2018-11-07" version="1">MPPRIPTEADFAPLSTTLPLALHLPSPPESTTAFLILLHGLGDSEAPFASFARAMALPGVLAISVRGVAPLPSALLLPPEGGGGGAGAHFHWGDDLSLDPRTGDIDADPGFRRASRAIIHQLIRGVLVEKCGWEVDDVILFGFRQGGSLALGLASELRNETLKGVVSIGGPLPVSMIPTTSARAKSHTEVLLCQLDEDMVDAVESEFEHVTVARWKRQDVTMPRNRDEMLPIMKFLADRLKTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4T1</accession>
    <name>A0A367L4T1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_3752</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000015">
        <property type="protein sequence ID" value="RCI09421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4T1"/>
    <dbReference type="STRING" id="1330021.A0A367L4T1"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF3">
        <property type="entry name" value="FERROPTOSIS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="5">
        <location>
            <begin position="4"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI09421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="375" mass="40073" checksum="D1EC8D70B9133E69" modified="2018-11-07" version="1">MPKTVLILGGSLAGLAVTHRLLKYTRPHVQDLRVVVVSKVNSHFYWNLASVRAVIPDLVQDSQLLQPIEPGLRQYPPDSVDFIVGAASSINTTAQRVHVSVIDGDDREIKYDYLVIATGADAADKDMPWKASGSYEDCLTSLHRTAERIRTAEHVVVGGGGATGVEVAAEIKYEFPSKTVVILNSSDTLVAGDSSAAAVESELRRLGVVVTKGVRGTPSDDAPRPDGKTVVHLSDGGFLLTDLYLPTTGLSPNTGFLPAHWLTDGGYVDVDECMRVPGASGVWALGDVVSKPRAGFLFTEAQAAGVASNIDLVLKGKGQRSVSAPYLDIFICSIGRDRGAGRIGPIPVPFFFIWAVKGRSLGMERTAKYANGTMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4T3</accession>
    <name>A0A367L4T3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_3730</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000015">
        <property type="protein sequence ID" value="RCI09453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367L4T3"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NACHT" evidence="6">
        <location>
            <begin position="397"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="1132"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="1272"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="1357"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="1530"/>
            <end position="1570"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="1676"/>
            <end position="1708"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1972"/>
            <end position="2004"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="183"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2106"/>
            <end position="2130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="183"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="2106"/>
            <end position="2120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="2195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI09453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="2195" mass="243208" checksum="CEF26B4FB07E5417" modified="2018-11-07" version="1" fragment="single">MSDPNSYSIGWISALELEYAAAQEFFDDEHEPPTYIHRHDDNHYALGRIGRHNVAMAVLPTGEHGIAAAARAAKDMRHTFPNIRVCLLVGIGGGAPNQGHDIRLGDIVVSTPSFHPESGNHGGVVQYDYARTIQSKRFSSIRFLNSPPVALLSAVAGVRTRHIRKGNTIHAKIEEMLRHRPRMRREYSRPDRDTDRLYASEGETVIPRQPRTEEDDDPAVHYGLIASADNFMESAEIRDILAEELGVLCFEMEAAGLVNSFPCIVIRGICDYADKHWLKPWRGYAAMAAAAYARELVLELVPAQIEAAKSIGQLLDQIDEHLGDLKVATSGTRREIETLRDVVLDNNQKAVLERLPNVPGAAFDSYADEPEPRCLPNTRVELLNQVKSWANNEEAESIFWLNGMAGTGKSTVSRSIADALHQESKLGASFFFRRGEEFRDNPSRLFTTLASQLATRRPIIAPLIKSAIDEDPFLPQKTLAEQFEKLIRQPLLAGLPPGQSKGVILVIDALDECEADNRAQLVLRVFRSYESLGLKLFITSRPEEPVRLGFMASGTKYKDLILQDISQDIIRHDLSLFMQTELERVRKNWNSIAPDTGGLAQDWPGTSQVRYLVNMAMPLFIFAATICRFLAESRCGNPDEQLQEVLRYGALSQESELNKTYRPVLDSLIARLSPRMTDKVLSQFRTIVGSIILLANPLSTRGLSRILRISQGIVDGQLRQLHSVLSVPQSARSPIRLLHLSFRDFLVDADQRGQNPFWIDEEKTHRELGSRCLQLMTEVLVRDICGLEKAGKLDSNVSEHQVDEHISAEAQYACLHWVFHFQGARDSMSGLDLEQIHTFLKLCFLPWVEVLCLMRRVSDGVMMVQDLKHLIQRQLPDVPYHADSHVEDKQSSPRQTLDDFLDDAKRFLRHNRSIIEEAPMQLYSSGLIFTPENSTVRKQFATWLPPFIRVLPTMSTSWSPLLQTFEGRPGTQWRRLAFSPDSRLLAASAWETVRVWDTATGAAVQIIELGVIDSSLSVQLAFSSNRHLVSVTEKYKSKQLNTLAAHWRDMTTGTGVTLDVCDVETDPYTYMDVDFLVTPEKRATTYRPLNCHREWMLSLDGAQLATTIGIGERNNRSSIRLCDTATGEMRELRGHASRIDACAFSPDGRILVSASQDGTIRLWERATGAALEIILLDAATILHKSICWCQMFVFSPENESAGCATHYKYFHCRDVTVSRGLRALFVRPTGDGPLIQPGNISFNGRHLASYEWASAPTFEVWDISTGALKQTFKSPHSFIRALAFSPDVQLIASASDDATVRLWNVGSDQVLRDPTDPARLACKLETLSPDGKTMALTRGSQAIESWDMSNGVSLPTLHGHSDPIRLLAFSPDSERLVSVSHSETRLWDLNSCTYMASLDPSIMHAESVVFSPDGKVALSRCKRSDYAVMRTKVWDWTNCAPFPGFLHYVGASAFSPNGKHIALALLDYRIALWNISAGHIERFLADQLPDLTGFMAFSPDGQLLASASARLCGGTIQLWDPATGVALQTLTGHDDWIAALEFSPDSRKLASCSSRRLKVWDITTGAVIGDFQDDMARRHKFRTEEVIVSFSSDGTVVATDTTLWNVASVLALSLKQDGPMTTNLWDVDTGALLFELDVVLGEDKHYYQFKYQDEMPRIPCAVSSDRRGQFASKTSALAFSPDSQVLASASGDGSVMLWDTKTGTVVLSLEQGDHDQSAILPPIIQVVRSAVSVIFSSDGNSLASLSHNSIRLWDATTGGLIESNSENLDSRIELDVTPDLQSGVAVSSLSFLLSEDLQYSLTEEEDSLSTHAAWSLNQGPFSFAMLEPSIRMRRAIHAGDVLLVRRILKSHPYLLRNPDASLMGLSNSNLHLAASLGHRDVCETLLLADHEKPCPALNEHHQTALMLAARAGHTEVVHLLCEADRSSILRRDIRGRDAVMEASIGGHDTILQLLLTYAPGGPNEAVQRADVEGNTALHFASSNSNFLGLRTLLAAGADVERRNVWSWTPAAYSATVQVEVYLKSLVNEVERRHHQLRRAIDPPSKGAAVRVVPSESTKLIVTQYLESRQDPPAWAWISVGAFLDHDDRIIWSTELFVAILDAQFESDDDDDGSTEEEVDENSYVSDSSSGTYGAPAGGVYVPGASGSFMTQQTFSYQPNGTGNMLPRQAQPWPVIDPSMPAAHMTNSSGGVGCEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5C4</accession>
    <name>A0A367L5C4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_4160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5C4"/>
    <dbReference type="STRING" id="1330021.A0A367L5C4"/>
    <dbReference type="OrthoDB" id="4927717at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI09636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="185" mass="19361" checksum="0A0BD07B1B0A20E1" modified="2018-11-07" version="1">MVTISSVSHRFLNMTTTSFVTKTDAAPSDSAVSFPPNVKINISQDVKVKIERYMDRFVGNETGSRTIPDSVIMPPQSKILEMVKLAAKVEDQGESRLTSGHVSPASSASRSIISNQLLEIFASASVSIQNSGCGSGACSVQVSSNYGSSPASSAPSAGDGVNSIWASAEVRVGQVDEDPEACEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5J1</accession>
    <name>A0A367L5J1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13 14">Phosphatidylethanolamine N-methyltransferase</fullName>
            <shortName evidence="13">PE methyltransferase</shortName>
            <shortName evidence="13 14">PEAMT</shortName>
            <shortName evidence="13">PEMT</shortName>
            <ecNumber evidence="13 14">2.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L249_3786</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + S-adenosyl-L-methionine = a 1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11164"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64573"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="2.1.1.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="13 14">Phospholipid metabolism; phosphatidylcholine biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13 14">Endoplasmic reticulum membrane</location>
            <topology evidence="13 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13 14">Belongs to the class VI-like SAM-binding methyltransferase superfamily. CHO2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13 14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.17" evidence="13 14"/>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5J1"/>
    <dbReference type="STRING" id="1330021.A0A367L5J1"/>
    <dbReference type="OrthoDB" id="4583at2759"/>
    <dbReference type="UniPathway" id="UPA00753"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004608">
        <property type="term" value="F:phosphatidylethanolamine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03217">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007318">
        <property type="entry name" value="Phopholipid_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016219">
        <property type="entry name" value="Phosphatid-EA_MeTrfase_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32138">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32138:SF0">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04191">
        <property type="entry name" value="PEMT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000383">
        <property type="entry name" value="PEAMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51598">
        <property type="entry name" value="SAM_CHO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 13 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 13 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10 13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 13 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11 13 14" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="12 13 14" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13 14" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 13 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="517"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13 14">
        <location>
            <begin position="566"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="16"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="348"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCI09681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="960" mass="107241" checksum="C07CB068CDC05B97" modified="2018-11-07" version="1">MTTALDDAQLRRRFKALDDDDGGGGGGHDAAAAVASPSAATESKATRSDAKGKKTFGRTPDGKGFVVPTTHDMVSQLLDPRQPKNLTDLVVLGFLALHIVAAWLLPAGWKRPVFALVFLGWRASYNIGIGVLLHVQSHHGRLITWARRWKLFEIRDNPRPWLYGLLKREFEAKITDDYVFEEAPIEYNTWLVFRRFVDLILMCDFVSYCLFAIVCGHVPKGEGFVMGAARWALGIALVGFNLWVKLDAHRVVRDFAWYWGDFFYLVDQDLTFDGVFEMAPHPMYSIGYAGYYGISMMAASYEVLFISIVAHMAQFAFLVAVENPHIEKTYNPPPPRLRALSHSQTDPTVLLAGPDDDDNDNDESGYGADRPPMEAPGAIESSTAVHDMVGLGNVDLFRVPDLAVVTLSMYMAVLTLATPSTAPWQAVFVAHALAWRVWYHLGLGIILDRQSKTKMWTRHFLKFGESAGEAWRQWKGMQHFCMIVCNASFMAACWKMYSAPEDWGYGLVLLRHVVGASLVALQLWTAFSVYGSLGEFGWFCGDFFFDHRAKLTYTSIYRFLNNPERIFGTAGVWGAALITWSAPIFIMAIVTQILSLYYLSFIERPHMQKIYGRSLRREAGLTKFIKRSLPPPVKGWQESMDRVLDDTGHFVEEFIEMARPKFASGVKTVVRDTSALFNMAPARLTITRIAPDLTGLDPKQYGLTVSGTASAQPRRATGNESLSGRFPKAVKTMAYEYGSPLRVRWRAPAEHSTGDWIGLYMVTDNRSREATEVSSLGRWAPTSSGVYDSLTADSSIATAEHEVGDGMVEGEVLFEGDKLWWTQGVYEFRYHHDGKHTVMAVSEPFEVAISPVLSSAEEEVVDSAQARAAVEVAILPMIQRCLDRDPDIAPNTVDEPFGGHVERDGKYARRIVYAIREMFGIEFAPAVVLADRNARKLAWRICNAKEVLSRGTTTPAAREV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5V2</accession>
    <name>A0A367L5V2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SUI1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_3910</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Additional factor that functions in concert with eIF-2 and the initiator tRNA in directing the ribosome to the proper start site of translation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SUI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5V2"/>
    <dbReference type="STRING" id="1330021.A0A367L5V2"/>
    <dbReference type="OrthoDB" id="10248435at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11566">
        <property type="entry name" value="eIF1_SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000005">
        <property type="entry name" value="Sui1 translation initiation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005874">
        <property type="entry name" value="SUI1_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01160">
        <property type="entry name" value="SUI1_MOF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10388">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004499">
        <property type="entry name" value="SUI1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="SUI1" evidence="6">
        <location>
            <begin position="29"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI09778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="113" mass="12865" checksum="27EF6003C37A6E7D" modified="2018-11-07" version="1">MSIENLKTHDPFAEADEDTGETKQAQNYIHIRIQQRNGRKTLTTVQGLPKKFDQKKILKVIKKKFACNGTIVSDTDMGEVIQLQGDQRKDVQHFLTDKEGLELSPKSIKVHGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L673</accession>
    <name>A0A367L673_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">Glycerol-3-phosphate dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="2 8">1.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_8612</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 8">
            <text>sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.8" evidence="2 8"/>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI09924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L673"/>
    <dbReference type="STRING" id="1330021.A0A367L673"/>
    <dbReference type="OrthoDB" id="10263760at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141152">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000004">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728:SF8">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(+)]-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13772">
        <property type="entry name" value="AIG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00957">
        <property type="entry name" value="NAD_G3PDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0520">NAD</keyword>
    <keyword evidence="3 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal" evidence="10">
        <location>
            <begin position="359"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal" evidence="11">
        <location>
            <begin position="614"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="537"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="545"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00072861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI09924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="770" mass="85957" checksum="33C6D5B4EB230DEE" modified="2018-11-07" version="1">MSQKLSWLILEIPRRHEIGDVTRGRNRIKLVMRPVNDNHGQKRGNRPISNVLGDQRGVEGGTSSTLSATFLGMRGIRPLSQVNVSVPDLRLTFDLRGVPYWEPCFANVDFRDLPEKDYGQASGEWDGRLMGVVYEVTLSDFGVIMRTEGAGSNYREMTVPCIPIKSGPGPQDDARPFQARTLRAPQQASSGKDINRHAGAQPSRRYLKLLRDGAREHGLPESYQRYLRSLQPYTITHWRQRLGRCLLLLIWAPMLLVFLKVTGFFVDETGKLPTGLATVMSMWLNLMWRSYEAMFKPVFGDGERTETVNDDDMDASEGHRRRLRSRRRRRRMFRVPLLLRFFHKMPAPLLLGGHVRKHKVTIVGSGNWGSTIAKIVAENTRTHKDIFEETVQMWVFEENVVIPPGSKHYDAAVGQQPQKLTSIINSFHENVKYLPGVTLPPNIVANPSIVDAVRDSTILIFNLPHQFIENVCDQIRGHILPYARGISCIKGVNVSDDAVSLFSEWIGDGLNIYVGALSGANIANEIAAEKWSETTIAYDPPPMDSRAPSPRSGSPLPSPGIILTEAPANHHRDARGRTSKTRLTPVPAQYPPLEHECFRLLFHRPYFHVQMVSDVAGVSLGGALKNIVALAAGFVDGRGWGDNAKAAIMRIGLMEMVKFGKEFFGETVQSSTFTETSAGVADLITSCSGGRNFRCARKAVDKGISVDEVEKQDLNGQKLQGTTTAYEVNSFLQRRGLEKDYPLFTAVNDILRGKKQVDDIPHLVAVMDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L699</accession>
    <name>A0A367L699_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">endo-1,3(4)-beta-glucanase</fullName>
            <ecNumber evidence="3">3.2.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_8439</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;3)- or (1-&gt;4)-linkages in beta-D-glucans when the glucose residue whose reducing group is involved in the linkage to be hydrolyzed is itself substituted at C-3.</text>
            <dbReference type="EC" id="3.2.1.6"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.6" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI09950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L699"/>
    <dbReference type="STRING" id="1330021.A0A367L699"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052861">
        <property type="term" value="F:endo-1,3(4)-beta-glucanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02181">
        <property type="entry name" value="GH16_fungal_Lam16A_glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.200:FF:000114">
        <property type="entry name" value="Probable endo-1,3(4)-beta-glucanase NFIA_089530"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF24">
        <property type="entry name" value="GLYCOSIDASE C21B10.07-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH16" evidence="7">
        <location>
            <begin position="23"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="319"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="325"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="350"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI09950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="360" mass="38645" checksum="3D33CB1FC89054B0" modified="2018-11-07" version="1">MRLSPPTLLGLAGALNAVRAEAAYSLCNTYDQSNFFDSFDFFTSPDPTRGFVEYVDQKTARQAGLVGNGVANNSFIMAVDSQTVNPTNGRRSVRLTSKDSFTRGLFLADIVHMPSSTCGVWPAFWMFGPNWPSSGEIDIIEGVNTQSRVAITLHTSPGCTVTNQGSVASTRLKTADCGANGSSGGCSQQTGGAAANYGDGFNAGQGGVYATEWTSDHIAVWFFPRASLPPDVAAGQPDPSSWGMPLARFSGCDMDSHFFNNQLVFDTTFCGDWAGNPGVWAADVTCSAKAATCQDYVAANPGDFREAYWEVNSVKVFQQKSTQQPRPPYGSSPPQPPPQSTGTTYPGYRRAAHKPMRWRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6C3</accession>
    <name>A0A367L6C3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_8639</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI09971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6C3"/>
    <dbReference type="STRING" id="1330021.A0A367L6C3"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF288">
        <property type="entry name" value="PALMITOYLTRANSFERASE SWF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="11">
        <location>
            <begin position="155"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI09971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="405" mass="46431" checksum="F478C3D1E3F42F41" modified="2018-11-07" version="1">MTSLKWPVIFVLCLSFIVFVIFFGRLPALRRTPIAALHRLIWIHLPAAMSAVDDRLTAGRLTRWLLRFGSCMLHDRHPTIVVFFLAILVGAEYLFLPEAWPLMRWWVKLGAVVVVSLPYLFLYLACASDPGYITPDNHAYHMALYPYDYALFHPGNECRTCRLIKPARSKHCSICKRCIARADHHCVFINSCVGYGNHHWFLSLLASTLFLTMSGAILGTQHLWFMMKERHPKYYLWKPNGMTLNNYLDVCAWTIQRNVRLGATTLLAMLTSPLVCGLLVYSLYLVYAGTTTNESLKWSVVKEDMDDGCAFRRLLPPNRKRDPRTEPLCHRWPVEPAHILVGTGDGQPPAADAGLHGEGEWEHVWKLKHVDNLYDVGFWDNLSDSFIRDYDFGRGAHVREKEGWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6V9</accession>
    <name>A0A367L6V9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8597</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6V9"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="87" mass="9129" checksum="9AE82140C6713CE8" modified="2018-11-07" version="1">MIDPIYGLPTHRQLSIHLYSDKIACLASSEGGFNQGKGSLRNGLQASAETASPDGPPLGEHNASQPSKEGGGVWQFVFGVFVSVMLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L705</accession>
    <name>A0A367L705_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">CSC1/OSCA1-like 7TM region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_8673</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L705"/>
    <dbReference type="OrthoDB" id="2150324at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF149">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11660)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="437"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="484"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="601"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="659"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="684"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="10">
        <location>
            <begin position="36"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="11">
        <location>
            <begin position="210"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="390"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="850"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="945"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="875"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="894"/>
            <end position="919"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI10002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="983" mass="109934" checksum="F18371470FCB8521" modified="2018-11-07" version="1">MDLPLLLLLLPRDDAGKELLDLLKNPFQGQLAAASIFSALGISLGFTAFIALCFSFLRPFNQAIYAPRLKHADEKHAPPPIGRKPWSWVTPLMRTSEASLVHQIGMDATVFLRFIRMCRNMFLVLALVGIVILVPVNVSSSIKEYQGHRTEWIMQITPRDVFGRPQWAQVVVAWLFNLIIIAFLWSNYRSVLRLRRQYFETDEYQNSLHSRTLMLYDLPRQARSDEGIARIIDKVVPNSSFARTAVARNVKILPELIEEHDHAVRKLEKVLAKYLRNPAQLPASRPTCKPSKKDRSFDTYPRNQKLDAIDYYTQRIRDLEIEIKEVRASVDKRGTMPFGFASYSDVAEAHSIAHACRRTKPEGATVTLAPAPSDIIWQNMPLSGATRSRRRWVNNFWIAVLTLLWVGPNAMIAIFLVNLANLGKVWPAFQTSLSANTVFWGMVQGIASPGLMSLVYLVLPIIFRRLSIQAGDQTKTGRERHVLAKMYSFFVFNNLIVFSFFSTVWSFVAAVLDRTSRGADAWDAIQKGNIAGNVFLAFCDNSPFWVTYLLQRQLGAAIDLAQIWPLIQAFFLKKLSSPTPRELIELTAPPPFDYASYFNYFLFYSTVTLCFAGIQPLVLVATALYFCIDSYLKKYLLLYRFVTKTESGGLFWRVLFNRFVLATILSNLVVLLTCWVRGEGTHMQFYAAAPLPLVMVAFKLYCRRAFDSKIRWYSTRLSAKMHDPVLHKEPRLRSEKLSTRFGHPALYKPLITPMVHSKAQNLLPSVYRGRLTDGRDATGGGAGGDLVSVSGYSDMYALDSMQQGGKPGKSASHNNNNNNINLPGFEYVSESHMDFAYYKNRAEFAEQHGGSELYGRPTTPGSLDDLGGGADTRPASSLSVTAAAAAAASQQQQRRVGTSSELSSRNRSPLYAQENSSSAGLVRNAAAPPTTATAAAAATTTMLGTPGPWGYSGLAQGEEEARQQQYSYFRGGNRPMRAPGEGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L756</accession>
    <name>A0A367L756_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_8522</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L756"/>
    <dbReference type="STRING" id="1330021.A0A367L756"/>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03181">
        <property type="entry name" value="GST_C_EF1Bgamma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03044">
        <property type="entry name" value="GST_N_EF1Bgamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000142">
        <property type="entry name" value="Elongation factor 1 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.110">
        <property type="entry name" value="acylaminoacyl peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050802">
        <property type="entry name" value="EF-GSTs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010520">
        <property type="entry name" value="FrsA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986:SF10">
        <property type="entry name" value="ELONGATION FACTOR EEF-1B GAMMA SUBUNIT, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06500">
        <property type="entry name" value="FrsA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13410">
        <property type="entry name" value="GST_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="451"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="538"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI10255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="672" mass="74635" checksum="A3E866B417B5BC55" modified="2018-11-07" version="1">MRQVFSSALFDFEFLRVLGAAPYHGAEIGECLEAASRINDGDPESWYRAWMNLGRRALASAEDAQARNDRTAACWAYLRAANYFRASEFFLHCTPDDDRILAAAQKSVDAFDNGWVLLDATVCNIVIPVSQGQTLPGRLYVPSAHQRLGAGKLPVIVQTGGFDSTQEELYFYGAAGALPRGYAVLSFDGPGQGLPLRRDKLRLRHDWEFITGKVIDYLVCELAPEHGLDSGRLAIYGASLGGQLALRGAFDPRIKACVSVDGPYDLFDVAHSRMPSWFINGWLSGWLSDGIFNLVVNGLAATNFQLRWEFGHSKWVFGVDSPAEVMRAMQRFSLKNDRLSKLRCPTLVTGAADTFYFTPAQNAEKIFEGLSQLRPAEKELWIGRGKSTGGLQAKIGSLALLHHKVFTWLDRQFGIQRSDAMMAGCTYRRRLFDFALTASALHTLSSPWYAMFGKLYSFMPNGRVYKVLAAAKLNGLELEVAEYQHMVTNRTAEFLSKFPAGKVPAFEGSDGLCLSESDAIAQYVAQSGPRAEQLLGRDATTGAQIRQWISFTDGEVTPHVLDLVIWRVGMGSYDDQKEVRALARLEKALDVVEGRLGGRRKWLVGDWGLSLADLTLASALVWAFLHVIDGRMRERFVHLTGWYLRIIGDEEVRDVFGPPSLISVRRASSEKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L767</accession>
    <name>A0A367L767_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Serine/threonine-protein phosphatase 2A activator</fullName>
            <ecNumber evidence="10">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Phosphotyrosyl phosphatase activator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_8559</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the PTPA-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="10"/>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L767"/>
    <dbReference type="STRING" id="1330021.A0A367L767"/>
    <dbReference type="OrthoDB" id="16120at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008160">
        <property type="term" value="F:protein tyrosine phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04087">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1150:FF:000003">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004327">
        <property type="entry name" value="Phstyr_phstse_ac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043170">
        <property type="entry name" value="PTPA_C_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="PTPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0697">Rotamase</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="58"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="408"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI10261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="458" mass="49273" checksum="8C92F9A6E39B14D2" modified="2018-11-07" version="1">MTSTPFSALAIIDPESAPPFAKPTKRIHTGQDVSRFLQSLAYRDLVTFILQLNHALCPRRQPPDSTTPSPTTTKPPRLFPLTPAPSSSSTPSVQALQLLLSDLESLIDEAPPDPGPRRFGNVSFRTWHSLVADKLPDLLSAGLLGRTLGAGQGLARDEVATYLLGAFGSPERLDYGTGHELSFVAFIGCLWKLGFFRDGELGGPIERDIVLNVIEPYLRVVRKLILTYTLEPAGSHGVWGLDDHSFMPYIFGSAQLTRPIDDAEPMPLEGSVGGAPKPSDVTKSAVVEEQRATNMYFSAIGFVNDVKKGPFWEHSPMLFDISGIRDGWGKINKGMIKMFDAEVLSKFPVIQHFPFGSLFSWDEDPHAPAPAQSVHMTHQPASTVAMTPPPPVTGTAAPWARVARTPPASAELGTAYRRGSPGPSTGSLASRPSRGQAVGPASAAAQITVTKAPWAKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7I4</accession>
    <name>A0A367L7I4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_4295</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7I4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI10371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="92" mass="10832" checksum="4321F5DB56A97F7F" modified="2018-11-07" version="1" fragment="single">TCCKDIRTFSRKKGEFSAFLTNLKDKIRTNKATFRDEEDRIGFLFRSLEGKARKTLETYLLTRTKDDSLSYEDFYSYVKDSAIKRLDAELVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7Z4</accession>
    <name>A0A367L7Z4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_4483</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7Z4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI10547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="145" mass="16538" checksum="0DE6FD2E0A940D39" modified="2018-11-07" version="1" fragment="single">MFEAPSIQPSRSPPPSSGPKTIDAMDLEAFFFFFFLSFHSLFLSPFPNVGLLRHAERCGRYCADPPYLALLGNSARRKRRRRRRRAPADEMPPDVSMSTKDISLLFPPLTTIVLQLHLTPKTLLFLHHFLIYFLTPPPSPLLTQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8E0</accession>
    <name>A0A367L8E0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Golgi pH regulator conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_5281</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8E0"/>
    <dbReference type="OrthoDB" id="264392at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025969">
        <property type="entry name" value="ABA_GPCR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022535">
        <property type="entry name" value="Golgi_pH-regulator_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015672">
        <property type="entry name" value="GPHR/GTG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15948">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR 89-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15948:SF0">
        <property type="entry name" value="GOLGI PH REGULATOR A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12430">
        <property type="entry name" value="ABA_GPCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12537">
        <property type="entry name" value="GPHR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Golgi pH regulator conserved" evidence="8">
        <location>
            <begin position="174"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Abscisic acid G-protein coupled receptor-like" evidence="7">
        <location>
            <begin position="299"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="337"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="338"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="352"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI10698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="426" mass="44810" checksum="28B21644DA58937B" modified="2018-11-07" version="1">MLPSAATACAPDGGGCGATTTATATALLALMALGFGLVVVLLTGVDHDGRWRRAMVAWTSGTTLALALALAVLVMADVAEVVDGAARDKALAVVVPALLLLLVVLVPWLECGNLASVLCSIRRLAFPLQLLLFGGWLMVFFSVGWAVPLFPTSAVTTKTTTTTTTTRTMTTALILGCLERVGVVGISSMAFLAGFAAVSAPWHTIWRRRRRRVTDEDVARSQAGLDAAVDMLASKRLQLSGLQHRDDEQALVAADLLRTGSGGNKAAEVRALRVDIAGLEAVEARLKSRLESMRDLRAAGTARGRVLALPSYVFSVYCVYRIAATALATVRRIVLSSPTPPPPLPPPPPPTDSSYPSSGDDPISRLLAQATPTLLDQASWTRTLSFLSSGLILAAGARSAIATFTCGHASEPPENRSQHKQAKLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAG3</accession>
    <name>A0A367LAG3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7686</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAG3"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI11405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="111" mass="12459" checksum="AFD6D4D1BF2D270C" modified="2018-11-07" version="1">MSKGEKKRERERVEGDAGWTRLESSVSAMREMKGKESKEKNGERAHVMRKGHHYQGLFCSVSGSWWGHGDEVRRLGSCFRRGCVACNACNGPVPSLPDGWRRGGDARPLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAS6</accession>
    <name>A0A367LAS6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Vacuolar protein 14 C-terminal Fig4-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_7486</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VAC14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAS6"/>
    <dbReference type="STRING" id="1330021.A0A367LAS6"/>
    <dbReference type="OrthoDB" id="5574975at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070772">
        <property type="term" value="C:PAS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026825">
        <property type="entry name" value="Vac14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021841">
        <property type="entry name" value="VAC14_Fig4p-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023:SF0">
        <property type="entry name" value="PROTEIN VAC14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023">
        <property type="entry name" value="TAX1 BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12755">
        <property type="entry name" value="Vac14_Fab1_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11916">
        <property type="entry name" value="Vac14_Fig4_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="5">
        <location>
            <begin position="140"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein 14 C-terminal Fig4-binding" evidence="8">
        <location>
            <begin position="637"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="496"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="825"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="865"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="338"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="826"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="865"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="916"/>
            <end position="936"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI11530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="960" mass="106616" checksum="B6EE96A719B0A558" modified="2018-11-07" version="1">MDANIQRALNDKLYDKRKVGALELVMPRNLGLGGSFDADTLTLPTYLPRLEKIIRDLVSSKDDQRVCDILEQLVNDYAYAVHQAHARNGGLIGLAAAAIALGAVCMRLFFVMHLSCPRPEMSDPKANDLSQELPRYLSKIVPPVLACFTDHDARVRYYACEAMYNIAKVAKGEILVYFNNIFDQLCRLGADSELSVKNGAELLDRLIKDIVSESAASYVSVLEASTELPAGDKTGLDDEPAKPPTAFSLSRFIPLLKDRIWVINPFTRQFLVGWITLLDSIPDLELVTYLPDFLGGLLRFLSDQHSDVRTATHACLDKFLNEIKRIARVKKGILESRKSREDGKGRRQDSDDTGSVRLDMEEGDEVDSDVLLEDDEDSAEEDWIPGQDVEINYKEVLDILTATLDSPLEEDCLLESLRWIVEFLDICPEEVLPFTPKILAHMLPAMASAKETIHRAATRVNTCLIDYVVSLSDDSGINATHTPVLAQYQAVSRLTSPGDKLDESNSNRASISSSRDKDARSVVQSHGRPPLQQAAPARVDLDYAAAVNSLTLLFLNDHEATRVAALTWLIMLHRKAPKKVLAFNDGTFPALLKTLSDPSDAVVTKDLQLLSQISRNSEDDYFAIFMVNLLQLFSTDRKLLETRGNLIIRQLCISLSPERIYRTLADCIEKEEDVEFASIMVQNLNNNLITAPQLGEVRKRLRNLETKDGQTLFVALFRSWCYNAVATFSLCLLAQAYEQAYHLLQVFGELDITVNLLIQVDKLVQLIESPVFTYLRLQLLEPEKYPYLYKCMYGILMLLPQSSAFAALKNRLNSVSSIGYLHTAPRSVSTSTSNPNYDRPSRLKGREDGSIRWVELLEKFRSVQDRARRTQRHSMDNDDGPPGGLSELRASDAASEGKGRESRGSTVPPPVPQKDATPAAAPVPAAATAATAATTAKKTGLGRQFGRLGGAVAGKTRRNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAT2</accession>
    <name>A0A367LAT2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">THUMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_7489</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAT2"/>
    <dbReference type="STRING" id="1330021.A0A367LAT2"/>
    <dbReference type="OrthoDB" id="367221at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11717">
        <property type="entry name" value="THUMP_THUMPD1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2300.10">
        <property type="entry name" value="THUMP superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040183">
        <property type="entry name" value="THUMPD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452">
        <property type="entry name" value="THUMP DOMAIN CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452:SF10">
        <property type="entry name" value="THUMP DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143437">
        <property type="entry name" value="THUMP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="THUMP" evidence="3">
        <location>
            <begin position="162"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI11525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="320" mass="35106" checksum="5FA555CE09BE2761" modified="2018-11-07" version="1">MAGGASKRKQGPGGAMGGESVGKRSKGGSRGRWKTPHQQAKTTETDGVLDVGDGGIWVTFVRGMQAKAVREFRALCGDYCESMYGMRPADDTTSEDEAADEKAIEKSIEDELSSLREKHKSSKPKEPFCPVLTGLDCLFFMKLSKPIDPAAMARKMCEDARDCPQPRQRKCRYINRLTPVTDTDRATDKGIVRVAHRVLAPFFSLQGIADGEAQGVEAASSPPCTYAIRYNIRNHTAFKSDAVIKMIASLIHERHKVSLGKPDKVILVEIFQLFCGVSVVDGKEWEALKRYNVNTLYEMSRPETGTEEAAKGPAGDGRQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LB39</accession>
    <name>A0A367LB39_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_7629</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LB39"/>
    <dbReference type="STRING" id="1330021.A0A367LB39"/>
    <dbReference type="OrthoDB" id="25887at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061025">
        <property type="term" value="P:membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031468">
        <property type="term" value="P:nuclear membrane reassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14273">
        <property type="entry name" value="UBA_TAP-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.210:FF:000002">
        <property type="entry name" value="UBX domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.210">
        <property type="entry name" value="SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036241">
        <property type="entry name" value="NSFL1C_SEP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012989">
        <property type="entry name" value="SEP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333:SF20">
        <property type="entry name" value="NSFL1 COFACTOR P47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333">
        <property type="entry name" value="UBX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08059">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00553">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102848">
        <property type="entry name" value="NSFL1 (p97 ATPase) cofactor p47, SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51399">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEP" evidence="3">
        <location>
            <begin position="228"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="354"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="320"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI11639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="435" mass="46635" checksum="54E57B4498CC2246" modified="2018-11-07" version="1">MADQNDADRDRKINDFCDMCSTSREMAISYLEAHEWDYPSACTNFFTEEEPADEEDSNLVSQSRAEEPYTGPRTVDGRPAPQAYRTSRNNEPPAKKKGVATLASLAAGSQQGGGGGGGGGGDDDDDDVDDDDLDGDTEDGRGNLFAGGEKSGLAVQDPKQDGGSRQIINDILAKARANASQPDSASSEAGPSRSSRFRGTGMTLGGEGVQSRAVPDPLGPVRPTNSQPLERILHVWQDGFSIDDGELRRFDDPANRNDLQMIRSGRAPLHLMNVQPDELVDVKLHQHDTPYTAPPKQYRPFGGAGHRLGSPVPPPPPPVSSVSPTTTTAGSTTTTTTTSAAHAAATAQEPAVDSSQPTLMLRIQMPDGTRLPARFNTTHTVGDVYDFIQGASPETRTRPWVLVTTFPNKEHEDKTLALGEMPEFKKGGTAVVKWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LB78</accession>
    <name>A0A367LB78_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Adenylyl-sulfate kinase</fullName>
            <ecNumber evidence="4">2.7.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">ATP adenosine-5'-phosphosulfate 3'-phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Adenosine-5'-phosphosulfate kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L249_7355</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BCC 54312</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the APS kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.25" evidence="4"/>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LB78"/>
    <dbReference type="OrthoDB" id="28947at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004020">
        <property type="term" value="F:adenylylsulfate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000103">
        <property type="term" value="P:sulfate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02027">
        <property type="entry name" value="APSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000212">
        <property type="entry name" value="Adenylyl-sulfate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00065">
        <property type="entry name" value="Adenylyl_sulf_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002891">
        <property type="entry name" value="APS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059117">
        <property type="entry name" value="APS_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040155">
        <property type="entry name" value="CEBPZ/Mak21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00455">
        <property type="entry name" value="apsK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003013">
        <property type="entry name" value="PRK03846.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048">
        <property type="entry name" value="CCAAT-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048:SF0">
        <property type="entry name" value="CCAAT_ENHANCER-BINDING PROTEIN ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01583">
        <property type="entry name" value="APS_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CCAAT-binding factor" evidence="16">
        <location>
            <begin position="578"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="domain" description="Thioesterase" evidence="15">
        <location>
            <begin position="1093"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="domain" description="APS kinase" evidence="14">
        <location>
            <begin position="1192"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="125"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="497"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="684"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="874"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="500"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="891"/>
            <end position="926"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00031464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCI11679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1378" mass="152113" checksum="B325260DAA7E7540" modified="2018-11-07" version="1">MPKKPKSKAGVSSKQQESFDEDALVRLTSTIEQGLSASQHKRKNPCSEGSSKQQRSKRHRTSQPNDRTGDDDLTLLEEIKALGGDEKDFDLINGIASDVEMDVEDSGRSVDERLKRELAALSKELGFSHIEPEEASEEEDGEGDRQEEKQEDGGSARQPTKDAGQGSGRGKAGSMIFEPLAEWHSAELASLPGPTSDQLGPFFASTEALKKHAKTLLDGDAEKYRTSIFASSSHKFLATIMSSGTLADKVSALTLAIQESPVHNIRALDALITMASKKSRAQAIGAIGALVDLLGPGNLLPSDRRLRTFQSQPGLLGALQRNSVKAWTSSQPLPGKLTGAHLMAWAFEDWLKETYFKVIQLLEAWCSDEIEFSRSKAVDFVCTLLREKPEQEANLLKLLVNKLGDRDRKIASRASFLLLQLQDTHPQMKSIIIRAVEQDILLRPSQDIRSKQYAINTLNQTILSNKEPEVAETLIRIYFELFITLLKAGGRIVSDDTGDATRSFSRSKGMQKGQTHGNKSNRSEASVPETEATDKLISALLTGVNRAVPFVGANDAIMEHHLDTLFRIAHSTNLNTGIQALLLIQQLTSTRHLAADRFYRTLYESLLDPRLVSSSKQSLYLNLLLRALKNDVDVRRVKAFAKRMLQIAGLHQPPFICGLLYVINHLRQTFPGLSTLLEEPERSVFDDDEAQKQERYDGRKRNPEHSNAHRSCLWEIIPAQMHYHPSVSVCAATLLDKGRVMPKPDLESHSLIRFLDRFVYKTPKPTEKARGASIMQPLRATKDVGDIWLGKKEAGPAAAVVNTAAFWNLKVENVAAEDVFFHQYFQHMPKETKKSTADDEEQEEEGIWEALVATQPDIDDDKSDEGFDDLEAADMASEDDGSSPAMSLDSDREEDTNDLAAIEADDDDDDDDDDDDDDDDDDDVDTGEQGQVVKEGDKASSAKSRRKALKELPMFASAEDYAEGMNLVVVGVASGTLGAAVAWRTLKAQGLGFYSDEASLTRFSVAEADEEARRVEETIDKHPLTAQLRQRPDLTESRPHMRMPAEYRARSLTAGALSGAGKVPVPARTWIEPGGRSLVSIVYVGDQLCGHPGLVHGGFLATMLDEGLAWCCFDALPYKMGVTASLTINYRKPTPASSFLVLRAKTVRVEGRKAWVKGHIELLAEPGEKPTVLAEAEALYVSPRYAALRKQRGLTIWLTGLSASGKSTVATALEQHLLHLGYAAYRLDGDNVRFGLNKDLGFSEQHRVENIRRVSEVAKLFADSATIAITAFISPYRADRDLARRLHAEAAGDAGDDTIPFVEVFVDVPLEVAEQRDPKGLYKKARAGDIKDFTGISAPYEEPLQPEITIKTHESSVEDCVARITQWLTDKGYIELPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBS6</accession>
    <name>A0A367LBS6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBS6"/>
    <dbReference type="STRING" id="1330021.A0A367LBS6"/>
    <dbReference type="OrthoDB" id="275457at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05271">
        <property type="entry name" value="NDUFA9_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000358">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 39 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF11">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="55"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="403" mass="45328" checksum="5791FEB7B8090DEA" modified="2018-11-07" version="1">MLRHPTMLRLMNSAAAVRKAFSGAVKTRLASDMTVTRNSSRIIRVEGGIGYTVSIFGATGQLGRYLVNRLARRGCTVVIPFREEMSKRHLKVAGDLGKVNFITSSLSHASLINIPPQEFDLRNTASIETCVRHSDAVYNLIGRNYPTKNFSLQDVHVEGTERIVAAVKKYHVGRYIQVSSYNANPASSSEFYASKACSIAIRQALSSGRGENIARDNFPETTLVRPAPIFGFEDNLLIKLASAISCTANNMQQHFWPVHSIDVGEALEKMLYDDSATGQTFELYGPKEYTMAQIKAMVDKEIFKQRWHLNVPKAVLKPVAGMLNRLLWWNTLSADEVEREFIDQTIDTGAKTFKDLGIVPGDIYNFTYHYLQGFRSSSFYDLPPTTEKEKREARKYIHVLNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBT7</accession>
    <name>A0A367LBT7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4201</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000009">
        <property type="protein sequence ID" value="RCI11893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBT7"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="90" mass="10330" checksum="5FAC666C7DC52664" modified="2018-11-07" version="1" fragment="single">KVVTYRYVRVLQVGTLKYLEKIISISFSHLLNTNTSPASNSSLISSFRLLPQVQLSDSGYLYTFNLFFTAFLFTFRPTNYLIRTVSSDAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LC12</accession>
    <name>A0A367LC12_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Guanine nucleotide exchange factor synembryn</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_4592</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the synembryn family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000008">
        <property type="protein sequence ID" value="RCI11957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LC12"/>
    <dbReference type="OrthoDB" id="5585685at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001965">
        <property type="term" value="F:G-protein alpha-subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007186">
        <property type="term" value="P:G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019318">
        <property type="entry name" value="Gua_nucleotide_exch_fac_Ric8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12425">
        <property type="entry name" value="SYNEMBRYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12425:SF5">
        <property type="entry name" value="SYNEMBRYN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10165">
        <property type="entry name" value="Ric8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="470"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="483"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI11957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="494" mass="55309" checksum="708613943379FF73" modified="2018-11-07" version="1">MVEPKGERATGPAKLEVVKELVCTLTNDLENATLLPSGPLPSPVSSFHCRGRVLMASAERVELLEQLKMYGRDPQFADPIFEKEGITMLLRHAFYSPSSETARAALRVLANAMLLKPETRQMFVNQGFASEACGELKKENWDNELLISRILFLCTYGTDVDLLELIEKHRLADNIVENLNRHVKAMSTKSKSKVDPMEELALMETLKLLFNVTHYCNEKISCFNAAVPHLVALLWRYDVRDEKPLDAPFGQLVNGLLNLDLGVEQCRSSLYPKRDPCKVSSRLLSLLSCAMKAYKDTDLEHTVTPLISLIDKLYENAPQAVRDQLQETLLPADEDRKAVLGRGQTLSARLLKNSTNPMTPALRDAISHLLFDLSDKDATKFVQHVGYGFASGFLFQNNMPVPASAAEAYSTSDSTGATKHVNPITGQFLDREQPTEGPQWTEEEKQREAERLFVLFERLKASGIVDVQNPVETALQEGRLQELDDDDDDDDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCB9</accession>
    <name>A0A367LCB9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_1261</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCB9"/>
    <dbReference type="OrthoDB" id="10266325at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI12065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="134" mass="15003" checksum="480B6E1D34F59211" modified="2018-11-07" version="1">MKASPSLGLRFGEMSRLCPSRERHKQTTAGPYALASATTTPTHPNSIMLRALGQRLGGVQRRGFSVKAIHSTFPTWLTYYSPHRHSTLFDHEENESRLNDIYDQGVVRGSSLPTVGRCLIDQSQTTLAMSRQWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCT4</accession>
    <name>A0A367LCT4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_0753</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCT4"/>
    <dbReference type="STRING" id="1330021.A0A367LCT4"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000328">
        <property type="entry name" value="Septin spn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="137"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="415"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="479"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="422"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI12225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="503" mass="56240" checksum="B28B08D1EEA1BC96" modified="2018-11-07" version="1">MDPDQGAPSPCPACQQARYHPVQVGYLHLCPASHSLACTAPTSTTASLAPFRPLHPFPLLPPASSLLLCRNLIPTTVVFSHCPPNSQAQLRHSTPLCSSPLLLRSAQDAFDTARRLSTPATMSSPAKMLRRKKNVKKGIQFCLMVCGASGTGRTTFVNTLCGKDVLQHKDSDDATDAHVEDGVKIKPVTVELELDEEGTRISLTIVDTPGFGDQIDNEASFAEIVGYLERQYDDILAEESRIKRNPRFRDNRVHAMLYFITPTGHGLRELDIELMKRLAPRVNVIPVIGRSDTLTPAELAESKKLVMEDIEHYRIPVYNFPYDIEEDDEDTVEENAELRGLMPFAIVGSEDAVEIGGRKVRARQYPWGTVEVDNPRHSDFLAIRSALLHSHLADLKEITHDFLYENYRTEKLSKSVDGASGNADSSMNPEDLASQSVRLKEEQLRREEEKLREIELKVQREINEKRQELLARESQLREIEARMQREATQSTTPAPDANGESAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDM9</accession>
    <name>A0A367LDM9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 12">Mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="5 12">5.3.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">L249_1105</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>D-mannose 6-phosphate = D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12356"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="5.3.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="11 12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the mannose-6-phosphate isomerase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="5 12"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDM9"/>
    <dbReference type="STRING" id="1330021.A0A367LDM9"/>
    <dbReference type="OrthoDB" id="6605218at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00423"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07011">
        <property type="entry name" value="cupin_PMI_type_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.441.10">
        <property type="entry name" value="Phosphomannose Isomerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001250">
        <property type="entry name" value="Man6P_Isoase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016305">
        <property type="entry name" value="Mannose-6-P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018050">
        <property type="entry name" value="Pmannose_isomerase-type1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046456">
        <property type="entry name" value="PMI_typeI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046457">
        <property type="entry name" value="PMI_typeI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046458">
        <property type="entry name" value="PMI_typeI_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00218">
        <property type="entry name" value="manA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309:SF0">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01238">
        <property type="entry name" value="PMI_typeI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20511">
        <property type="entry name" value="PMI_typeI_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20512">
        <property type="entry name" value="PMI_typeI_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001480">
        <property type="entry name" value="Mannose-6-phosphate_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00714">
        <property type="entry name" value="MAN6PISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00965">
        <property type="entry name" value="PMI_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00966">
        <property type="entry name" value="PMI_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phosphomannose isomerase type I catalytic" evidence="16">
        <location>
            <begin position="5"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphomannose isomerase type I helical insertion" evidence="17">
        <location>
            <begin position="167"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphomannose isomerase type I C-terminal" evidence="15">
        <location>
            <begin position="353"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001480-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001480-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF20512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RCI12342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="449" mass="48093" checksum="35516A08406FE9E3" modified="2018-11-07" version="1">MQPPLFRLRCGVNSYEWGKKGSKSAAARFAAATPSDSLSIEPDKPYSELWMGSHPSNPSRDVVSGRALSDLFVENKALLSVEVAARYGDRLPFLLKVLSIEKALSIQAHPNKKLAEKLHARDPGNYPDDNHKPEMAIAITPFEGLCGFRPLAEIAHFLATVPPLRSLVGDDNTRHLTGVAASQKNEHDEGARTALRSAFNALMSSNADDVSREVANLVGLAKSESAGFAGGGVSSSAGQDLAELVTRLHGQFGPDIGLLVLFFLNLVKLQPGEALFLVADDIHAYLSGDIVECMAASDNVVRAGLTPKFKDVKTLVDMLTYRCAPIEQQKMAPADYPYATLNRTAYSSGSAVVLYDPPIDEFAVVRTLLRGVGAKATMEPVDGPSIVICTAGRGSIAAGPTRHDMAEGYVFFVGASAELVLESAVGDEDEFTTFRAFCELPDQKPRASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDN2</accession>
    <name>A0A367LDN2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDN2"/>
    <dbReference type="OrthoDB" id="8300194at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="38"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="265" mass="30093" checksum="E82DA326196E04B1" modified="2018-11-07" version="1" fragment="single">MASTGRLSLLQRFVRWLEDWTLSLRLRLGSKILYDDVRKIVRISRSELVKGPCSRQELEAMEYVAAHTSVCLPRVHRTYDRPEGLFIAMDYIDGTCLDTVWSQLNDTDKREIVMQVWHYARQLHACRPPASLNRPTAASVSGGPVRDGILGVDDVGAVTVGPFATAGDFHHLTRGNPDVEAFPRSPPHTGLVHADLTPRNVIRTADGRLCIIDWEFAGWWPLYWERVKWYFSDFPTMPDWVTLLDEVSGWTTTVGEERGNLDEGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEX0</accession>
    <name>A0A367LEX0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U3 small nucleolar RNA-associated protein 6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_0035</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UTP6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEX0"/>
    <dbReference type="STRING" id="1330021.A0A367LEX0"/>
    <dbReference type="OrthoDB" id="28112at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013949">
        <property type="entry name" value="Utp6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055347">
        <property type="entry name" value="UTP6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08640">
        <property type="entry name" value="U3_assoc_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 6 N-terminal" evidence="7">
        <location>
            <begin position="12"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="221"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI12961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="402" mass="46561" checksum="C0CB096D0DC403AD" modified="2018-11-07" version="1">MAGVAEKARFYLERSVPQLREWEEKGVFSKDEIRTIVQKRNDFEHRVLSPGNKPSEWSSYAKWEQSLEALRTKRCKRLKVRHMNSAYAGQSRVMAIYERSVNKHPSSGELWYEYLAYLTVIKAAKRWRKTMTSALRMKPTDSDLWIMAGRRSVHNGDMASARSFFMRGCRFCTKDFKLWLEYARCEMQWLAKIDKRKGAQKNDPLRSDRAEDHDELHLLESEGDDDDDDDDDDDDIQPETRVHEASNVVPDFLDKQVLESNPAMDGAIPMSIFDISQKQTFFDAEFAEMFFILIASFRHVSVQPKISQHVLDSLDTLFPNHPSTCSCHIRQPILGTSPHTADFPLNLRDVLVRLSERLKSTTDRSALIQKTMAWMDEYLALDDLDQSIRTVLERTKGKLAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LF28</accession>
    <name>A0A367LF28_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 16">Phosphatidylinositol transfer protein SFH5</fullName>
            <shortName evidence="16">PITP SFH5</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">L249_0203</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Non-classical phosphatidylinositol (PtdIns) transfer protein (PITP), which exhibits PtdIns-binding/transfer activity in the absence of detectable PtdCho-binding/transfer activity. Regulates PtdIns(4,5)P2 homeostasis at the plasma membrane. Heme-binding protein that may play a role in organic oxidant-induced stress responses.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)(out)</text>
            <dbReference type="Rhea" id="RHEA:38691"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:38692"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 16">Endoplasmic reticulum membrane</location>
            <topology evidence="2 16">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="16">Microsome membrane</location>
            <topology evidence="16">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the SFH5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LF28"/>
    <dbReference type="STRING" id="1330021.A0A367LF28"/>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017157">
        <property type="term" value="P:regulation of exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042938">
        <property type="entry name" value="Sfh5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47669">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN SFH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47669:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL TRANSFER PROTEIN SFH5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12 16" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 16" id="KW-0492">Microsome</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="18">
        <location>
            <begin position="140"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="294"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RCI13025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="395" mass="42442" checksum="E461FD887410A989" modified="2018-11-07" version="1">MTAQHQEIPIAQLMGRLTGIKMAARHSEMWGVELEEDSLPTRVILIKFLKANGWVVAEAARHLIRALLWRRRWKPLMLLEREHDRDKFEGLGYVTVHSPGDNAEALPDGMLVVTGGHDVVITWNIYGAIKSKKKTFGNVQEFMEYRIALMELGMQKLQLNSVRHAMDPLLEDPYRIVQVHDYADFFAWGLDSRLRSASSELVADLATAYPETMSRKFLVNVPRVLDMAHGALRWVIPSEMMRKVTPLSSRTKLASELKEIEGTVPNAYGGWGRGIHDGFSPLMTQPLTKVVVEGPSKSVAAREDRQASAGGDDDGGGGGGAAAAAAAAAAAAITAPPATATSTAFRGRRAGSVSVGGGGGGGGVGVGGVGRRISAQAPTVPEITLVHDDGPPSWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LF32</accession>
    <name>A0A367LF32_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_0626</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LF32"/>
    <dbReference type="OrthoDB" id="5368485at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016445">
        <property type="entry name" value="Rog1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482:SF62">
        <property type="entry name" value="LIPASE ROG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005412">
        <property type="entry name" value="UCP005412_abhydr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="4">
        <location>
            <begin position="275"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="170"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="249"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="498"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="618"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="751"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="195"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="513"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="582"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="758"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI12842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="843" mass="93244" checksum="8BF9D9CF3F9A5827" modified="2018-11-07" version="1">MALRLRILNTCPTTRRIAIYPGPFTLSANAYPAVFDPYRKLDRPEEYGVPRFEPQIKAGSSWECDLMIPTWASDDDDVSWVVELSSQAVFATSAVVAYELLVASDQGDLVRRGLVPDARPGRLVDHRDFMREAGEPSSLQSSGVFSTAVKLKVEDTALLWGLPPMMAEESSFSASSSSTMMVKQREEEEEEKKEKKEKKKQKKKKKKKIHLVVLTHGLNSAIGADLLFLKEAIDAAAAAAAAAAAAAAAAKKKTKKTKTTTTKSDDDEDDDDDAENEHEHVVVRGYSGNATKTQRGIKFLGTGVAKYVLSITYPDQPYLPPGTTAHDGRLDRRQTYQVTSISFIGHSLGGPTQTYAVAYIQKHCPAFFDLIRPRNFVTLASPMLGLSGENPLYVRLALEAGLVGRSGRDLGLSWGPKTIARSGWGALQPPGSKPLMQILPTGPAHEALSKFANRTVYANVVNDGIVPLRTSSLLFLDWQSLDRVERARRDTGLITNVGRHILTQVQPPTTSSSRRRRRRRRRTRLHQPDQDLATTVPQPTDAEAADIEQDPLTPAKAPTTTGLSPLPQPPTLLASFFKLRKSSNNSQQSSSSSSSSPSPDRFVPLRHKQMLSRGQTFHFDHLPSADGTGTEPQSTESPPRPEADIRAPPTTTFLEGFGDVLTPVVPVLDFIVDPESRPKTIIHDRLYRPVDIPPTPDGADMRVEERVARSYHRDMSWRKVLVKMEPDAHNNIIVRRKFSNAQGWPVIKHLVDTHFGGGDDDDDDDDDDDDEKEEEEEPVSPVKPPLPPRTYSEPMLQLDQMEPDPLLAWCEADWQDSEDSDTDEDGGRLRRLAAHFTTDGVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFC7</accession>
    <name>A0A367LFC7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFC7"/>
    <dbReference type="STRING" id="1330021.A0A367LFC7"/>
    <dbReference type="OrthoDB" id="3219396at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039719">
        <property type="entry name" value="FBXO28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13252">
        <property type="entry name" value="F-BOX ONLY PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13252:SF9">
        <property type="entry name" value="F-BOX ONLY PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="7"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="595" mass="66265" checksum="A76F43BC17BDD2BA" modified="2018-11-07" version="1">MASSRRPLPWDELPDEIVLHILRYLDPCHITRLQFVSRRLRKLCLDEKLWRQLCFQDSSWYRSVQNRRALVKNPADLLGVDPGWRRRQDKANWNPVYPGENVSWYDEYIQRHGPASVNWLQTPRKHDGGLEALVEARGVALYSPHDGRDGVGTMFAVSPLEDGSICLWDVNGNRARQGSIVARSRPGKLFMEAHNARRSRRVDADVIECVSVSDSGHRAFFAVQSHLVEVDLNRLDVVNRTGFEWSITALSAVHDGVPLTVGTSLGIHLHDFRARTRAGHDMAERVDGPLEGVAHPFKAIFDPNPLPPYAPLSQPTPISILHLPRQGSPDQASDDIYVAGRFSNILHYDRRKFPSIAGSIYSGALIKSLTSLPGSFSAVHSELRRQAELSVAQTKTEMAGQTLIAGGGYNTKGSLEMYGLNTAADSAGHGMLQNSAMKNRQTAASATILSIINHGTKLVFSDGTGLLKWFERDGSTECRRLRIGHSDSEEEGSLFASMPASDDLARKILSTRPKQGPERPNDDNILFWTGEKLGMVTFTAGPRFDYGPTPEESSAAEQEEEMRRRAYVERMRRALDCQADEVRFTGNLEMGMGAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFG3</accession>
    <name>A0A367LFG3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFG3"/>
    <dbReference type="OrthoDB" id="5229184at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016679762" evidence="1">
        <location>
            <begin position="20"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="149" mass="16510" checksum="A2797D281C5DEDA3" modified="2018-11-07" version="1">MMLAYNMIVNLMLLHMVLAAPAVSNDVTVNSNITFTGRVKLNNTATYNNTKVTIYPTRKCVQGSSTGGNRLEFQYERVQSNSTAKTNNSIIEPSFFNRHATAGNSILWLGDKPPPAYAESRCQFSCNAMLGCRMSGNLTSFQCYFLNDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGF0</accession>
    <name>A0A367LGF0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5507</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGF0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI13513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="117" mass="12276" checksum="E731BAD50AAEEB09" modified="2018-11-07" version="1" fragment="single">DLTNLIDLIDPINPIDLTRYNRYNVPAIAPVGTRPEGLGGSRDAGPAVAGPRPPYVIEARLRHGYGYGYGCTGRTGPLLPSFSSGMAPSAAPPDRAPGDTVGVLIVIDRGLKRIAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGK6</accession>
    <name>A0A367LGK6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGK6"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="59" mass="7091" checksum="1BAC410915FA200C" modified="2018-11-07" version="1" fragment="single">RARYSGYSGSDRSDRSDRLDRSDWSDRYKSSSKSPIFLLFSPSQYKHFSCLQFFFNFLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGL0</accession>
    <name>A0A367LGL0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGL0"/>
    <dbReference type="OrthoDB" id="10681812at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="388" mass="41327" checksum="3A52E8E9847637FF" modified="2018-11-07" version="1" fragment="single">GLCHASSSSSTDRWLVVTPSLQSRSARKSQPCGPRFASTNKVCLTSPIESLHAWHLPPLPQGSDAGIGFARPHEKIPSFTALFISTLPLLYSETVTFFHTLIHPSSLFFPSQVEKMKFLPVGTAFLATTLAAPTGDKHDYKDVDYKNGGYGDGDFKNGKYGDGWKDGGIDVHGGDNKHGGEWKNGGYNGGDWNKGGDYKNGGDWNKGGDYKHGGDWNKGDDYKHGGEWKNGGYNGGDWNKGGDYKHGGDWNKGDDYKHGGDWNKGGDWKNGGYDGGDYKHGGGDYKNGGGFKKGGYNYGEYDSGKKGGDWKGEDHKGGLGGLDKGLGGLDKGLGGLDKGLDLGWLLDGKHQGGKGFDGGKYGGGKYGDDKYDGGKYGGGGKDNSDKGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGL8</accession>
    <name>A0A367LGL8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_5597</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGL8"/>
    <dbReference type="STRING" id="1330021.A0A367LGL8"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF43">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="38"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="149"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="258"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="169"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="258"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="312"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI13549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="753" mass="82461" checksum="5FCE9D5DE2CE0268" modified="2018-11-07" version="1">MIRVMPIIRSRTGCFTCRRPRLLRLPTESTRLPLARRLIAIVVIFVVFVVFVVFLSLLVVIVFVFFVFVFILLVLLDTSALSLTSATRQQQQLQLQLQQQQQLHEKTSLTIDSGSKRLLEPACLPARVVPLALSTEEQQCRLYQQHPYTQPHHHHNHQHQHHHHHHHQQQQQQQQQQQQQQQQQQLQQQQRQHQQQRQLQLQQHQHHFQTPAVEPPPTPARRCSSSTIGPFSTADDLGPSVDAATDAVEEHVSALPLPAASPSASSTVSSPPASSPSSSSLSSSSSPSSSPSTSTPSASSALLPPPPPPPTTTTTTSTSSAPSFPIPAVSEADFAAVQAEERQQNHHHLQQQQLQQQNGIGLPVALLPAQGHGSYELLSYYLSRTADSMGNGSTDVNPFIAKLVPIAFSNSLVLQLLLAQSAAHRQASHGPEAGTEIAQQYYTESLRMFRTVVGDFVSGKEEHTLTLTVGSLILCLTEVARGDVYGSILDHLSASRALLTMLLERPELSGDLIDFLVEFYMHTVASSIIATDPCGTRQPPLSPGIEQTARALVSRRYVGQLCGCWLELLLLIPQVFQLGQALLPAVGGAGGAVVAPTADDIITFGFLQSQILAFYPPPGVGAYSQLAGLVFKQGALLYLWSILGPPGPNSALSDLIDGAVAEAVSLLGQFPASVRVNTSLCWPLAVIGCCTQDRAIRDMLRERLQTMVETIGLGNMRETLALLEHVWRQPAEEMSPWTLHRSMREHQIWISFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGN4</accession>
    <name>A0A367LGN4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_5555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGN4"/>
    <dbReference type="STRING" id="1330021.A0A367LGN4"/>
    <dbReference type="OrthoDB" id="4918558at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI13586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="24439" checksum="AA14B5120DF97276" modified="2018-11-07" version="1">MIFALVFVCTRIAQIVTLIPIMGMLAWFVNIFVSNNALTPDSILILFITTVLALAWAVFTLFSYHRSSANARFVALVDLAICGTLIAAVYQLRGIASADCVPNPSPPRFWAPLVGVPSGLGWGPADKPCAMLKASWAFAIMNIIFFFFTALAAFSHGDHLSAIAYDDGRYRESERHRHHHHRHHHHRSHSDGGRVRSRSRHSSRSHRSPHSYTRHVYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGU0</accession>
    <name>A0A367LGU0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Transcription elongation factor SPT5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_5569</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the SPT4-SPT5 complex. Interacts with RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SPT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGU0"/>
    <dbReference type="STRING" id="1330021.A0A367LGU0"/>
    <dbReference type="OrthoDB" id="28901at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06081">
        <property type="entry name" value="KOW_Spt5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06082">
        <property type="entry name" value="KOW_Spt5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06083">
        <property type="entry name" value="KOW_Spt5_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06084">
        <property type="entry name" value="KOW_Spt5_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06085">
        <property type="entry name" value="KOW_Spt5_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09888">
        <property type="entry name" value="NGN_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000018">
        <property type="entry name" value="Transcription elongation factor SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000029">
        <property type="entry name" value="Transcription elongation factor SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.940:FF:000005">
        <property type="entry name" value="Transcription elongation factor SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="entry name" value="NusG, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041973">
        <property type="entry name" value="KOW_Spt5_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041975">
        <property type="entry name" value="KOW_Spt5_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041976">
        <property type="entry name" value="KOW_Spt5_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041977">
        <property type="entry name" value="KOW_Spt5_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041978">
        <property type="entry name" value="KOW_Spt5_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057936">
        <property type="entry name" value="KOWx_Spt5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005100">
        <property type="entry name" value="NGN-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039385">
        <property type="entry name" value="NGN_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039659">
        <property type="entry name" value="SPT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024945">
        <property type="entry name" value="Spt5_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022581">
        <property type="entry name" value="Spt5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017071">
        <property type="entry name" value="TF_Spt5_eukaryote"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125">
        <property type="entry name" value="SUPPRESSOR OF TY 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125:SF7">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12815">
        <property type="entry name" value="CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23042">
        <property type="entry name" value="KOW1_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23284">
        <property type="entry name" value="KOW2_Spt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23291">
        <property type="entry name" value="KOW4_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23290">
        <property type="entry name" value="KOW5_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23037">
        <property type="entry name" value="KOWx_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03439">
        <property type="entry name" value="Spt5-NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11942">
        <property type="entry name" value="Spt5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036945">
        <property type="entry name" value="Spt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01104">
        <property type="entry name" value="CTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="KOW" evidence="11">
        <location>
            <begin position="484"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="11">
        <location>
            <begin position="537"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="11">
        <location>
            <begin position="660"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="11">
        <location>
            <begin position="756"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="domain" description="Spt5 C-terminal" evidence="12">
        <location>
            <begin position="866"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="813"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="901"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="952"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="977"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1022"/>
            <end position="1064"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR036945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI13619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1073" mass="115995" checksum="E904E3A3D802C165" modified="2018-11-07" version="1">MAPSDAPHFDDSEDEEDFNPAPADISDDEPANDDTEKNSRRDARDSNPRNRDLDPDNNDEDDDTRRKSQADNADAEGDEDESVRPQGVEDFEDEQDDEDEGDDDDEDDEDVQQGHRRKRRRDRRNAFFDIEAEVDDEDEGEDEEKDGEEIEDFIDNAHPDDVAESARLDDDRRHRELDRRREMEASMDAEKQAEILRQRYGNRRPAKGFGDSTVVPKRLLLPSVDDPSIWAVRCKEGKEREVVLSLTKRIEERLGTKDELAITAAFERGGTQSVMKGFIYVEAQRQTDILVALDGLLNVYPRSKMTLVDIKDMPELLRVTKTPTLEPGAWVRLRRPAKHGGDLAQVLAVTENGLEARVRFIPRLDYGMRDDALTALTADGKRKRPGGPAGPRPPQRLFSEVEARKHHPRYIQGNPSTNTWSYMGDEFENGFQVKDVKIQQLTVTDVNPSLEEVTRFASGAEDGTENLDLKALAASLKDSNTLVTYLPGDIIEVYSGEQKGVVGKATNVQGDIVTMTVTEGDLEGQTIEVPIKGLRKRFKVGDHVKVIGGSKFRDEVGTVVKLSEDRVTLLTDQTNTEVTVFSKDLREASDIGGQGSLGQFSLHDLVQLDPTTVGCVVKVDRESLVVLDQNGDTRQVMPSQISNKLPKRKQAVAADRDGSEIRLDDKVKEYTGQQRQGKIIHIHRSFIFLHTNDSTENAGVFVTKASMVNTVAAKGGRVNATSSGPDLSTMNPALKIHKNGAENKAMQPPVKQFGRDRAINQTAIIKKGPYKGLLGIVKDTTDTHARVELHTKGKTITVPRESLSFRDKTTGATIDINGRGRAPSGGFNRGSGDRVPSWQGASRTPVGAGSSERVPAWGSRTPAASGGRTPAWKAQDYSGSRTPAWADGSRTVNPYDGNRTAYGSGSRTPAWQSGARTPAAGDAFGAGSRTPAYGGGMESWASGSKTPAWGSSAPTPGASGNDSWGYTPGATTTAYDAPTPGAGFGAPTPGALNAPTPGAYSAPTPAASAPTPGEGWQGGWGAESAPTPGAGAPTPGASEFVSSSGYYGAPTPAAYGAAPETPAASGPRYTDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHR8</accession>
    <name>A0A367LHR8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein yippee-like</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_7900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the yippee family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHR8"/>
    <dbReference type="STRING" id="1330021.A0A367LHR8"/>
    <dbReference type="OrthoDB" id="6407410at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016972">
        <property type="term" value="F:thiol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034751">
        <property type="entry name" value="Yippee"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004910">
        <property type="entry name" value="Yippee/Mis18/Cereblon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039058">
        <property type="entry name" value="Yippee_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13848">
        <property type="entry name" value="PROTEIN YIPPEE-LIKE CG15309-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03226">
        <property type="entry name" value="Yippee-Mis18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51792">
        <property type="entry name" value="YIPPEE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Yippee" evidence="5">
        <location>
            <begin position="13"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU110713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI13968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="110" mass="12638" checksum="5626DBEC86A7A98B" modified="2018-11-07" version="1">MGLAYNTYLNSSKIYGCKACKTHLANHEDIISRSFRGQHGKAYLFHNVVNVETGDPNERNMTTGRHVVRDITCRQCKETVGWKYDKAYENSEKYKEGKFILEAELLCNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHZ5</accession>
    <name>A0A367LHZ5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA mismatch repair protein PMS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_8133</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI14007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHZ5"/>
    <dbReference type="STRING" id="1330021.A0A367LHZ5"/>
    <dbReference type="OrthoDB" id="10263226at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000710">
        <property type="term" value="P:meiotic mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03484">
        <property type="entry name" value="MutL_Trans_hPMS_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.100:FF:000001">
        <property type="entry name" value="Mismatch repair endonuclease pms1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000014">
        <property type="entry name" value="Mismatch repair endonuclease pms1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="entry name" value="MutL, C-terminal domain, regulatory subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF52">
        <property type="entry name" value="MISMATCH REPAIR ENDONUCLEASE PMS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="6">
        <location>
            <begin position="232"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="5">
        <location>
            <begin position="793"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="373"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="609"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="676"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="402"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="522"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="631"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="696"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="711"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="727"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00070941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI14007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1015" mass="111469" checksum="46390972AA820C3A" modified="2018-11-07" version="1">MAATIKPIDESSVHQIQSGQVIVDLCSAVKELVENSIDSGCNSIGLLFYTPLTCVRSSDVRFKNQGLDLIEVQDNGSGISPANYAYVALKHHTSKLSSFSDLASLQSFGFRGEALASLCALSRLVITTCVQADVPKGSRLSFDTSGVLTETAVVASHRGTTVSVNGLFQNLPVRRRELERNIKREWLKVCALLHQYACIQTKVKFSVSQQPSRGNRTVLFSTRGNATTRENIMNIFGTRIISGLIPVDLSLNLQSSTPNLDSRDVGYYEGRLVGYVSRPSSRDGRHTPDRQMLFVNGRPCSLPRFVKTFNEVYRSYNSSQSPFIFVDLRLDTHRYDVNVSPDKLSILLHDQSLLLKGLRTSLDELFSSHQGIMPVSQTTHGSQRTKDEAKMPPLPKKLSFIGSDQSSRSINDTLSSDDELLPLNLADSNTNVEEEVRQDGGSDERQVATDPRNKGSSSPRLDKSWKVAWTPASLESDMNEGQAKTRRKLQSTQVPNVVFHGSRTGGLAPFHAKSYRNQRSLSDPRENSKDRPFLDCTSNSDLSSMDCDAQNEAEGYTAGGSNRDSRPPPVESLCLDNNHYTGFPIPSPQLCTLEVAGVTQSREVVGLAKDKPSLSTGGYEPANLGRPTAVGGNSSGLSSDSANVQDARAQAASGRDHKCSVFDDTNNASKAELEDAVALSSDDADGGIPIEDQTHAESLQDNNLDQSRFSGRGEKSKRLEDGLGRDSQLSGTAQRVQTTEEHVQSRMRDYLSGYWVENDNMSMLDTAEDNMAPDAESQLTVTIARDHFSRMRVVGQFNKGFIIAVRPATLQNMEDSRARHDELFIIDQHASDEKYNFERLQSSTIVQSQALVVPKSLRLTALEEEILSENLAAVEANGFKVRCDASQGGSVGSRCQLLALPLSRETTFDLGDLEELITLLGDEPSQSGYIPRPSKVRKMFAMRACRGSVMIGQALTPSQMATLVKQMGELDKPWNCPHGRPTMRHLCQLCAWESKSWKADLSAPVLSSWISFLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LI65</accession>
    <name>A0A367LI65_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7913</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI14118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LI65"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="38" mass="4346" checksum="9947F3B56FB3751F" modified="2018-11-07" version="1">MRSYEQALADTQASLSQEQVTRRQVLEHMQASHSAELD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIP0</accession>
    <name>A0A367LIP0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIP0"/>
    <dbReference type="OrthoDB" id="4925962at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.15.10">
        <property type="entry name" value="Proaerolysin, chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016843795" evidence="1">
        <location>
            <begin position="17"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="311" mass="34984" checksum="581168E9C303905C" modified="2018-11-07" version="1">MMTILLLLFHALAVQAARPNDLSNLGNHPDIKAHLRGLGEHFSLRLSEDNLPYQDRDSISEPVCPHKIFSCSTVYFYQRYKMIRVDNITFSAISNIEASLITPYDPHDERYKFPAKISTTVSRAVTSSTTKGWKVSLKLGGGLSGDPTQSFASGGADLSGEYSEQYTSTTTTTRSVGVEAPCEAGKLCTIQTLTYLAHLEGRCRVEPIINCGGEEDACHKFETKTVNLHPDLQKGPPLKISKWRDGPCRQWTDYSRRHCRRNRYLEVKCKVSTPVLNRIEEPYTSTVITKKDLPSFDSTGERRWEQVQFAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIU2</accession>
    <name>A0A367LIU2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_6064</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIU2"/>
    <dbReference type="STRING" id="1330021.A0A367LIU2"/>
    <dbReference type="OrthoDB" id="427368at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057646">
        <property type="entry name" value="WD40_WDHD1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022100">
        <property type="entry name" value="WDHD1/CFT4_beta-prop_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048591">
        <property type="entry name" value="WDHD1/CFT4_hel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932:SF10">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20946">
        <property type="entry name" value="Ctf4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12341">
        <property type="entry name" value="Mcl1_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24817">
        <property type="entry name" value="WD40_WDHD1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDHD1 first WD40" evidence="9">
        <location>
            <begin position="9"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="227"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="WDHD1/CFT4 second beta-propeller" evidence="7">
        <location>
            <begin position="413"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="WDHD1/CFT4 helical bundle" evidence="8">
        <location>
            <begin position="771"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="325"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="707"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="870"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="388"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="707"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="728"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="875"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="885"/>
            <end position="895"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI14344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="895" mass="99292" checksum="C6D335637C171A97" modified="2018-11-07" version="1">MDRPRPRPRPAHTRGTTRCAYSNDGTRLVTVGSNNTIRLYKTGSDGEPVNIDDCQEQNAAVATSSDFFVVGSEDGTVSLYSLDGAAFERFLLRALSPIRDVALSRDGQWCAVASGELSVKIVHTTDTTRVRHLREHVRAARHVSLDPNATLAAVSCTDGVVYLYSLTSDEPQLIRKIDGVIAALEDDSAASTRAQWHPGGKVFAIPTPTRDIQIVSKHDGEKQRCFSDGHLADITSLVWSPNGAMLASASKDGKILVWETKTQSVIQRHEYAGVIDLAWHPSSNILSFTTADGEVYIYPEFLPDQFVPLLKLPLQPAPFIHDPLSETGNQRHMPAAGRKDPGVAPGRGRRESLGSLDSFLGPGVDGYADEDDFVVDDDGAGYATGTKRPWDGEGAYGEHDSKRISTPRPRYHEAFQPGSTPWRGNRKYLCLNLIGFVWTVDQDSHHTITVEFYDHELQRDFHFTDTFLYDKACLNERGALFSSPATDEKPAYMFYRPHESWTKRHDWRTELPRGESVVAMSLGESFVTVTTTASYVRVYTLLGMPYRVYRPKSAPMVTCASWRDYVLTVGNGPMGADGTTRLLYTIENVKRDEICQNEDTVALPQGATLKSVFFSDQGDPCIYDSTGTLLTLLHWRRPSRASWVPVLDTKLLPRLASGRKHETYFPVAVADGKFHCIILKGGEQYPYFPRPLLSEFELSVPLASRREMKKTRKKKGEKGKEKAAVANGEEDQDELMTNDDDEKEDDGTSGDDDDDDDAAAAVADDDDERTRLEQQFMLKGVQAAQLRDVIAARNNSHRQRSQLSRVELELDKVLLQLLAVECREGEERGMRAVEMVALMRDRTGRMMEAAGKVAERYGRTVLGEKIREIGERRLGGGGGGGAGGADEEGDEEESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJ68</accession>
    <name>A0A367LJ68_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Heavy metal tolerance protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_5935</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJ68"/>
    <dbReference type="STRING" id="1330021.A0A367LJ68"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18583">
        <property type="entry name" value="ABC_6TM_HMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000287">
        <property type="entry name" value="Multidrug ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF503">
        <property type="entry name" value="MITOCHONDRIAL POTASSIUM CHANNEL ATP-BINDING SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="419"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="496"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="277"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="594"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="854"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="854"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="888"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1038"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1141"/>
            <end position="1157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI14461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1166" mass="126501" checksum="CCBD97383771DF8C" modified="2018-11-07" version="1">MEIVTELQQPAAVPLLYYLYPTAIFVYFLAASLASACTLQRFKDDADFQPRRRRLVQVILALFLVAYLAQLVSLIICALTDHRWPPADYQVVGILSCLLIFGIQLSCLAGADGHRVSFAFHGSWFLALAFEVLIAALAASAVGPGPPGPYQMTEVALAAVRSVLMLLVGAPYWVGLFTPAPTPDEERDPLLPKPSDAAQPAVATVNEAGYGATSSGADQTSANAAEYSWERREREARQAMEKRLKEGGNWFEYSKGFMILFPYVWPVNNYALQLRAAAVVACLFATNALHLFIPRQTGIIMDSLSGSSSTNPWLAVIVFAVLRLAASESGVELLRQWLWIPVKYYAHDSITRAAYSHMMHLSADFHDSKSSSDMMMAIYGGSAVSNVVENILLQAVPMLIDMGVAIVYLSVTFGPYEGLVTVATGTIFFILASRLVAESKAVSRKRVHALYQEHYVRQSGLLGWQTVSAFNQIGYEDNRHANAVTNRWLNEQQYVLSWYISIAFQTIILTCGLLVSAFLAVSRIRSGNATSGQFAMLLMYWSQLTSPLQFFARLGKSMSDDFIDAERLLDIMRTKATVENKKGARPLKFVAGNVEFEDVSFSYDGRRGTIKGVNLKIPAGETVAFVGATGAGKSTLLKLLDRFYDVTEGSIRIDGQDIRDVDLFSLRDRIGVVPQSPILFDDTIINNVRYGRITATDEEVYEACRAACIHDKIKAFTNGMFLNSLLSEKELTISLGYETRVGERGVKLSGGELQRVAIARAILKQPDIVLLDEATSAVDTDTEQQIQASFKTLCQGRTTFIVAHRLSTIMNADRIVVVEHGQVIEHGDHSELVAKKGRYADLWSKQVFLKPRDKADVTPPVDERAEVGDDSSSAQTVADPYKGVTTDSDSEVFCPDDEQAQAAAETPRQQTLEVSKLNPVAPEFTPRTMTGRRSGSDEKTSVSCSGEASVSGERDSNVAASGLSPSSPESKHARGNEAGAGSQKEASDLMDVEEMALSSKDGHVEPEAAAAQDTSRPAAVANGRAEAAMNRDEGIGRSQHSAGDTSKSEPCQATPALETLTSLPTVEELAAPRPMSSSHIPRPTSRGPAVLQPVSETKGSKAVPIKVDGGRPKAAGTENEPPTKSSRAVMPTATGRGGLRGGRRGRASWPRGHRGRGSARTEASSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJ86</accession>
    <name>A0A367LJ86_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_7015</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cerato-ulmin hydrophobin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJ86"/>
    <dbReference type="STRING" id="1330021.A0A367LJ86"/>
    <dbReference type="OrthoDB" id="4500971at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23508">
        <property type="entry name" value="hydrophobin_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.120.10">
        <property type="entry name" value="Hydrophobin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010636">
        <property type="entry name" value="Class_II_hydrophobin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036686">
        <property type="entry name" value="Class_II_Hydrophobin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42341">
        <property type="entry name" value="HYDROPHOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42341:SF1">
        <property type="entry name" value="HYDROPHOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06766">
        <property type="entry name" value="Hydrophobin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101751">
        <property type="entry name" value="Hydrophobin II, HfbII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017075546" description="Hydrophobin" evidence="4">
        <location>
            <begin position="16"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI14503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="123" mass="11925" checksum="718FE5BF7E9682A3" modified="2018-11-07" version="1">MRLLALAMLFVGALATPTDYHNGGGGGDDGGWNGGGGGGGGGGGGGGGTVPFACSPGLYSNAQCCATDVLGVIDLDCKSPSKTPTSLKDFQGICAASGGRARCCVIPVVSLNHKSTTTSDDQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LK26</accession>
    <name>A0A367LK26_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="9">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_6474</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="9"/>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LK26"/>
    <dbReference type="OrthoDB" id="20839at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15492">
        <property type="entry name" value="PHD_BRPF_JADE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019542">
        <property type="entry name" value="Enhancer_polycomb-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050701">
        <property type="entry name" value="Histone_Mod_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF107">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10513">
        <property type="entry name" value="EPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="11">
        <location>
            <begin position="446"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="12">
        <location>
            <begin position="490"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="188"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="409"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1043"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="190"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="206"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="430"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI14793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1407" mass="153790" checksum="E3A41EB1191DCE82" modified="2018-11-07" version="1">MAPASPTPRRTPTGRRRGRPPGSTNAARAARQAAALANAEPPPKRRRYVPGGPGGGGRFVEPPTDSSGLSRTGRAITRDLPNEGAAAGGGGGGGGGAGGAGGGGGGIGAADSPSAVARRERSTRTRAAASADMVDVRWGSAAAMAASVKQAEDYKPREERGWEEFHPNLDIERPFVVFLADEVDGASHLTPATPAAQTPGTPLANGNGSVTPSRQPKPSSADNTPMPQENADSVPCDGPNGTPSRRPRRQARDVVSFYGARPVDMPKTPKILPIQSQTPKERLDLKLPSYRKTNRIELFESKTFGQARYVDKSMSNVGYQESDHFIRPSATLIKAVDGNAEDEPDPSSTAKADDHAPHWRLGRVEYDMDEQDDMWLEQYNGQRKQNELEVITREVFEITMTKIEKEWHGLEKRIPKPNPKPPQTHRPRSSSDAAVNGETQTGEEPDSKCAVCDDGDCENTNAIVFCDGCNLAVHQECYGVPFIPEGQWLCRKCQLCGRGVPVADQFVQQTNSSKWAHLLCAMWIPEVSLGNHTFMEPVMDVEKVPKTRWKLSCYICHQKMGACIQCGNKNCYQAFHVTCARRARLFLKMKTSQGALAVLDGGMILKAFCDKHCPPDYAQENGVHQATRVAKKFYKRNMRDRIWADNQAMASVIAAQHRNAITEHPPDESQMTGAKNSAVLGEKRKGGQAPRNLWKLPSGAPIIPQAVFDIVEASIQRFPFRKRKDFLSEACRYWTLKREARRGAALLKRLQLQMETFSSMELTRRSFASMGPGGRARLARRIEFAEGIIRDLAQLKTLADDVVQREQIKVDAVELEQDFVDECYFPVAQLLPPAIEKATSLDKNLFADGLAKLQSRIEQRFYVSALCFAQDLGDVIGGGIATPPVTEEVPEQRFEAADTAPAKNAFSDIRERRKLGKRILKAVQPYLEAALRAESEITNKPFDGLQKELEALMDASIEATRAPVKLEGEEGEDEDTIMVDASEITVKSGTNGDGQAMDTVEAGSAENRNGGGNIEVKTSGLGIVHRGGPEAMRRAGRGVAAAANGGLNGTSETPPESDGFVPMNRQTAAGPPTPPQSNGSFGKEPGDPLADGGVLWYLKAMQPVGTTIVGEHWAGRDAVRMLSEDLTDLDDEELQGLGADVVDAVAAAAAIEGETADAAAAANAAANAGATLRHLLRELSIVMADQHEVDLDSIIDRLLEVRGSRPGKQVQLLEAEIRYLCTKAREIFISQPILLELEAPIKICGDIHGQYYDLLRLFEYGGFPPEANYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFILRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIIDEKIFTMHGGLSPDLNSMEQIRRVMRPTDILKPAEKKQKYVYGGLGSGSKPVTPKFKSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKK3</accession>
    <name>A0A367LKK3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytoplasmic dynein 1 intermediate chain 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_6764</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKK3"/>
    <dbReference type="STRING" id="1330021.A0A367LKK3"/>
    <dbReference type="OrthoDB" id="366230at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010970">
        <property type="term" value="P:transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000414">
        <property type="entry name" value="Cytoplasmic dynein intermediate chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF22">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="514"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="22"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="148"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI14951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="698" mass="75910" checksum="A37BC6A63781E9AD" modified="2018-11-07" version="1">MQQRRDEILAKKAKLAELKRQRELRATSAAGRHSLSGSSDMLVPQLASPPPGRADNRREIESLINSLVGESRPASTTTGGAASPAARGSRPNSVLSAGEISNAASDLAGHLNGLVLPAPQISLSTVPLTTVYECPPSPVKEIFSYSKGVQTTDEWGSPTKPRSLSISSDTDDLAGATTTPNKRQSRRERDREEELRQKIREEVEEELKATKKLLADGPAQAPPLTSANYPSRELSAEELEAVTRSDDFVEFLEQSTKVIERAIDQETYDILTDYALQGKDLDDDDDETGNTGGRGSHRIKEVTQFFDDRWSKKRMVSSIEFSPKFSELLLASYTKNPTAPHEPDGLVQVWNTHMQERPEYVFTAQSDILAAKFSPYHPNLIVGGSYSGQVLLWDTRAKSAPVQKTPLTGFGHAHPVYSVDIVGTQNANNIISCSTDGVVCGWSMDVFAQPQELLELKNPTQTKVAVEDVSPTCLAFPQADPTSFLVGSEEGTIFPCHRYDRAGAKAGVDKSISYKGHTAPVMSVDFHPARGPVDLGDLVISSSLDWSVKLWKVRALAATSTTAVGDGHIAPLIDFVREDVVYDARWSPVKPSVFALVDGAGWLELWDIALETEEPVSRISPSARHDSRAMLSKSLNKVAWEPNDGKRIATGGIDGSLTVFEVASGLGGKEGLKNEEWTRVKKLLNRVEAVGLNGAMVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKL0</accession>
    <name>A0A367LKL0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_6479</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKL0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="106" mass="12256" checksum="F0D834A3CC5458C4" modified="2018-11-07" version="1">MMMSNQGVNHVIEKKKTNHVIVVFTTIEVGRYDRYWYSASIAVTITVQRADRCDDRCNESIGRYDRYSPTVTQGVVAGLRPNWYNLFQVALQAYFLSVQDEKICVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LL00</accession>
    <name>A0A367LL00_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATP synthase subunit delta, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">F-ATPase delta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L249_6619</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase epsilon chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LL00"/>
    <dbReference type="STRING" id="1330021.A0A367LL00"/>
    <dbReference type="OrthoDB" id="270171at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12152">
        <property type="entry name" value="F1-ATPase_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.15.10:FF:000003">
        <property type="entry name" value="ATP synthase subunit delta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.15.10">
        <property type="entry name" value="F0F1 ATP synthase delta/epsilon subunit, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00530">
        <property type="entry name" value="ATP_synth_epsil_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001469">
        <property type="entry name" value="ATP_synth_F1_dsu/esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020546">
        <property type="entry name" value="ATP_synth_F1_dsu/esu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048938">
        <property type="entry name" value="ATPD_C_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036771">
        <property type="entry name" value="ATPsynth_dsu/esu_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822">
        <property type="entry name" value="ATP SYNTHASE DELTA/EPSILON CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13822:SF7">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT DELTA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02823">
        <property type="entry name" value="ATP-synt_DE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21334">
        <property type="entry name" value="ATPD_C_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51344">
        <property type="entry name" value="Epsilon subunit of F1F0-ATP synthase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATP synthase F1 complex delta/epsilon subunit N-terminal" evidence="14">
        <location>
            <begin position="32"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="F1F0-ATP synthase subunit delta C-terminal" evidence="15">
        <location>
            <begin position="118"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF21334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCI15116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="161" mass="17288" checksum="26693B5625865F90" modified="2018-11-07" version="1">MNSLRLARAVVRPRISPLRSAVQRRSYAEAIKLSLALPHKSIYKSQDVVQINIPAESGEMGVLANHVPAIEQLKPGVVEVIEEGGATKRFFLSGGFATVQPGSAMSINAAEGYPLEDFSPEAIRSQIAESQKIANGNGSEQDIAEAKIELEVLETLAAHVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LL04</accession>
    <name>A0A367LL04_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5672 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6618</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LL04"/>
    <dbReference type="STRING" id="1330021.A0A367LL04"/>
    <dbReference type="OrthoDB" id="10025998at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043729">
        <property type="entry name" value="DUF5672"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18922">
        <property type="entry name" value="DUF5672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5672" evidence="1">
        <location>
            <begin position="122"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="342" mass="38778" checksum="AC9FF53319BD7420" modified="2018-11-07" version="1">MALLGSGRALISRARLLILGSLALTWYLAFLAPPYQHAVQIEVSSRISKARRRLVGLPSEFNSSKVAMLIEPRPLPQLVPLTMHMVAVVPPDWSFLFIGSPWSVYNVGRSPAVRHQQALGKMTLATLPKPWAMQTREDVYRLLTDMRFYDEFLPGVEWVFKYDHDCILCANSPWSLDDWLDWSWAGAARSDKDEFPGAGGLTLRRVSAVRRVLGFQSRLNDSEPEDEWFGKRLSAMPGEKVAAEPRSPFAVRDMLTERPMGYQVQADGPSIEASVWKRRDVRRKTLEYCPELSMLMDMKLERERCPDDDMEGGRTGQQVWTAVERVGKPRQQATAAEGRRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLI1</accession>
    <name>A0A367LLI1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLI1"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="396" mass="44030" checksum="3D91901F24E3BE22" modified="2018-11-07" version="1">MYRLQYQYSHKGGFQQSSLCIFQVLMPPTCRRRRRGATLAPKQPSGQPRAPLRSVYEYDPRGARTAPSEFRGGSDLGPSSLSRKGDVEFKASTGHTDVKGRGGGAQKRSQRLDDFLFFFSQQDIRARSHLGLAAKGNSCSQAKADDDRCPADWPPAKANSVYATTKGQGQGSQKEVIHVRHLTIYVETKRAVGVEMRESETRRMMPARHSTLYIQTWMRCRVGRVLLPHAFLLRVFAWASDRDSLLPGHAMALRSRNRASKRAPIDNPRLFRGSARHGVTERVESCAGGRTWEGGFGCLADMTIFGGGVEPNGSRMDWDWNGSVGSDQGPSRMPTTGIHGYRVVVCDRDKAPNLSIYTGPPDRTGQLRTSSRVFASWRRRPPASGEYSSIFSTEML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLV4</accession>
    <name>A0A367LLV4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone-lysine N-methyltransferase SET9</fullName>
            <ecNumber evidence="12">2.1.1.372</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Histone-lysine N-methyltransferase set9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">SET domain protein 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L249_6560</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Histone methyltransferase that trimethylates 'Lys-20' of histone H4 to form H4K20me3.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:64456"/>
            <dbReference type="Rhea" id="RHEA-COMP:15554"/>
            <dbReference type="Rhea" id="RHEA-COMP:15998"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.372"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.372" evidence="12"/>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLV4"/>
    <dbReference type="STRING" id="1330021.A0A367LLV4"/>
    <dbReference type="OrthoDB" id="6627536at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140943">
        <property type="term" value="F:histone H4K20 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10524">
        <property type="entry name" value="SET_Suv4-20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1700">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041938">
        <property type="entry name" value="Hist-Lys_N-MTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025783">
        <property type="entry name" value="Set9_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039977">
        <property type="entry name" value="Suv4-20/Set9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE KMT5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977">
        <property type="entry name" value="SUPPRESSOR OF VARIEGATION 4-20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51567">
        <property type="entry name" value="SAM_MT43_SUVAR420_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="16">
        <location>
            <begin position="111"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="272"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="577"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="279"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="360"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="577"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="618"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="630"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="671"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCI15380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="688" mass="76913" checksum="7F7DD5E7C37DF003" modified="2018-11-07" version="1">MPAVQRRRLTLAQLAAYDDILTDALVDRVFYWTSVPKNRSSYLPSRGVCEDDITTIIRNDVIVARDLAAAEAKLLATTGLRRFHQSLKTPQEREDFRRHLLRYLQIYLPDCPWEVGSTNRYTIFSHEACVTARRPIARNEAIRYLAGVQVNITPDEEKEMAVRKKDFSIVVSSRSKSASLFMGPARFANHDCMANARLVTTGHAGIEIIATRAIAVGDEVTVSYGENYFGDDNCECLCRTCETRLCNGWIPENPAEVAKPDEPEAEGYYSLRLRPREGSSTAPASASSRAPSDAPVIRPRSYKSRKRGSGLVNLADEFCSSPPPPPSLLVGRKNKASDTPPETPAKRLKLLPGQDAVRSPSASIGDTVDTDFTSPDKQSPETDATSPGKDTPETTNTSSDKGNLGMDAADGLLKREDSGDLDHILQSSVEARPTPPSASIVSSSASTPLAKSIEAVEENQASQATAGTRTPRRRKYNRRRTFIKQATPPPRQRTPGDYVLTRHLLSEPETAWIQCSNCSSYFVQQNAYVMRSSCPRCERHSKLYGYVWPKTDREGPSDREERILDHRTVHRFLKPRNERLVRGRKPPADVEAVKETASEEMSSGRKGGRKTIAVKQTVTKRRRKKRKQLDDDDDDDDDNDDDDDDDDDDEEDNKEDEQMVSVQNTLEGGRLLRRSSRSRRLSRRIVPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLY5</accession>
    <name>A0A367LLY5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA repair protein REV1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Reversionless protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">L249_3468</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28 29">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents. Involved in mitochondrial DNA mutagenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LLY5"/>
    <dbReference type="OrthoDB" id="427711at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017125">
        <property type="term" value="F:deoxycytidyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17719">
        <property type="entry name" value="BRCT_Rev1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01701">
        <property type="entry name" value="PolY_Rev1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000001">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000040">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000011">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000109">
        <property type="entry name" value="Ornithine carrier protein AmcA/Ort1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1280">
        <property type="entry name" value="DNA repair protein Rev1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025527">
        <property type="entry name" value="HUWE1/Rev1_UBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053848">
        <property type="entry name" value="IMS_HHH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013248">
        <property type="entry name" value="Psh3/Shr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031991">
        <property type="entry name" value="Rev1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038401">
        <property type="entry name" value="Rev1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21999">
        <property type="entry name" value="IMS_HHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16727">
        <property type="entry name" value="REV1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08229">
        <property type="entry name" value="SHR3_chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14377">
        <property type="entry name" value="UBM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00786">
        <property type="entry name" value="SHR3_chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="19" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="16" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="18 23 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 23 25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15 25" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="1359"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="1387"/>
            <end position="1409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="1447"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="1711"/>
            <end position="1732"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="26">
        <location>
            <begin position="135"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="UmuC" evidence="27">
        <location>
            <begin position="433"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="23">
        <location>
            <begin position="1611"/>
            <end position="1699"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="23">
        <location>
            <begin position="1712"/>
            <end position="1802"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="23">
        <location>
            <begin position="1825"/>
            <end position="1913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="289"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="824"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="969"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1065"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1476"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="333"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="834"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="1486"/>
            <end position="1496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00058985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00081902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="RCI15419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1917" mass="211397" checksum="8B1B5B8C7E31C619" modified="2018-11-07" version="1">MRYQANGHSGSLCRVGKHKLAEPIIIHLSTAMKAEDASTRKVLSDLTKVVASLQRRLILNRPADPAASSEPPPPNMGSVLDKNSSAVRKRIEKHSFDNEDGEEYEASKFHGFGDYFRRKKVKLQNLDAATRAASEKPQIFKGIVAHVTGYTQPPLHMCAGPPFDIQIVEHGGGFLQYLDSKTMATHIIASALPPKKTVDFGRYRIVKPAWIVDSVQAGKLLPWSDYRLANEGPRQKVLKLDGDRSISQTSPEARRGYREQTDNSFYTSQMKATTAGLPSQGLSQVVEKLQTPPWPGPASSRTPERSKTDMTGLNSDWCALGASGSPKPPSSAQEPPTTVQSTVSKQPTTDRGKNVAAKKMTSEEHNSLLLSDPRFRKSSTANPDFLKQFYSESRLHHLSTWKANLKSTMQRMATEKCLYQEKPRRRPGERRYVLHVDFDSFFCAVSMKRHPELADKPSVVAHSPGPGSEIASCNYPARKFGVKNGMWMRRALELCPDLKVLPYDFPAYEEASRLFYESILSIGGVVQSVSVDEALIDVTSIVSPTSDSQAVESDQRNIERGRQNADDLALSLRQQIKAKTGCDVSVGIGGNILQAKIALRRAKPAGQFQLKPEQVLDVIGELRVEELPGVSYSIGGKLEELGIRLVKDIRDVSKERLASALGPKTGDKLADYARGIDRTEVGEQPPRKSVSAEVNWGIRFLNQQEAEEFVYNLCRELEKRLVSEQVKGKHLTIKIMRRCLDAPLDAPKHLGHGKCDSFNKSAAFGVATHSYDIMGKEAVSMLRSFKFSPGDLRGLGIQMTKLEPIKVYSKAPGGSQRTLAFNAFAGPSPARKPSRTEQIDDVESPGKARSPGDRDIDMDPITEDPITPRKQSLHPAMALSRAAQDDAKAKTPLNVSGTQFLIPSNPDPAVIAELPYDIRRRLMGQRARCSPPRPAPRSDSPVFAEELPSQVDPQVFNALPEEMKAEVLATYGRKRQRRPSPRKDGDTLSRRPTGRGGMRGSISKARRQRDSRAGVMQTTFKAAKRDETPTEDEVVELDPEFLAELPEDVRQEVVADHRRRRLARRSGLEAAAHRHRTSDADVPLPGEQRRIQFPEPRRKIAFGSGVTSTQEIKGMLDAWHGETRDDGPHADDVEVFERYLTQLVLEEADLEKAVMLVKWLDVLVQQDGGSAAGCASWRQAARQVKEALQGAVGQRGLAPLNIWILGRRDGEADWRDECLTGGCHALDKPSDSPGPAPIGTFHLVAHQDTTTTRATSPAKMAPYVDYAKTTRSKGYRGSGSFATFMIIGRTYSPLSSHRSPPSENMAADRIFTATCFFLGILFASFPYDFPLLWTKEPAGDDYYDQLEAHLKFLHHSPPLIGRMLNIVVSVGFLGLFIKLFRPSEANFLFDGASLILYTIGVAVYVSNIVQGLRTLSSGLWDSQEFQDNREGRFEGEFILGRKDSLKVLAASNTILALVLIGVLVLQAGQWYAEKRESDDDDNMESGKTAGATTTATTKKKHKSGLGVRCIRKPVLGDRVWNKDHAIRATVSALGFIPSPKMKGTRFFAGQWFALPDMKRMSTTLGVIDVAASYAGPLVCARHHHALTLAESRPVAVEQGSALSLASKPGLIRAVEDIFYGSIAGVVGKYIEYPFDTVKVRLQSQPDHLPLRYKGPVDCFRQSIKSEGVLSLYRGVSAPLVGAAAETSSVFLFENIGRQILYRTGTYSRDEALPVPVLWLTGAFAGFFTSFVLTPVELVKCKIQAPILADGKAATPLRPIPVIRDVYRHEGFRGFWHGQLGTLIRESGGCAAWFGAKETVTSLFHRFGTPPNASAAEKEAFLAKPLPLWQQALAGASAGVSYNFLFFPADTIKSRMQTAPVGGLAKKRTFWSEGQALWRQHGLRGMYRGCGITCFRSAPSSAFIFMVYDGLKRHLPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LM17</accession>
    <name>A0A367LM17_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_3597</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LM17"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI15468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="52" mass="6055" checksum="8E42EE52B5BC53FF" modified="2018-11-07" version="1" fragment="single">EWREGRCEGGYLYRGSASAESALTLNSLHRREINREKEKRPTVHPVEWGWGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMB0</accession>
    <name>A0A367LMB0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
            <ecNumber evidence="8">4.2.1.93</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">ATP-dependent NAD(P)HX dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_3425</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6S)-NADHX + ATP = ADP + phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19017"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>(6S)-NADPHX + ATP = ADP + phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32231"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.93" evidence="8"/>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMB0"/>
    <dbReference type="STRING" id="1330021.A0A367LMB0"/>
    <dbReference type="OrthoDB" id="8110916at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047453">
        <property type="term" value="F:ATP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110051">
        <property type="term" value="P:metabolite repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000023">
        <property type="entry name" value="ATP-dependent (S)-NAD(P)H-hydrate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01965">
        <property type="entry name" value="NADHX_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00196">
        <property type="entry name" value="yjeF_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592:SF0">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="1 8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF C-terminal" evidence="9">
        <location>
            <begin position="13"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="178"/>
            <end position="184"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="222"/>
            <end position="226"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI15575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="337" mass="35702" checksum="01C83C279A4C1450" modified="2018-11-07" version="1">MEAMSLSTTTRGVLERARRMIPPLLDKFHKGQLGRVGVIGGSLDYTGAPFFSAMASARLGCDMSHVICTPGAGAVVKTYSPNLMVHPLLRESGEEGDEDSEEAARVAASVIALLPRLHVLVVGPGLGRDRLMQATVARVVTAARERGMPIVLDADALLLVQRRPGLVRGYAGAVLTPNLVEFGRLWDALRPGDDGETTTTTTTTKPVETLARALGGVTVVQKGAVDLISNGRLTLADDLAGGRKRSAGQGDSLTGAIATFLGWRKAYHDGLWDGNDEDDRLSEEETIGLAAFGGSAITRESSRLAFIKKGRSLQASDLTDEVHNAFIALFGDVDGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMH8</accession>
    <name>A0A367LMH8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Manganese/iron superoxide dismutase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_3608</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMH8"/>
    <dbReference type="STRING" id="1330021.A0A367LMH8"/>
    <dbReference type="OrthoDB" id="275227at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43595">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S26, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43595:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="2">
        <location>
            <begin position="130"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="2">
        <location>
            <begin position="213"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI15618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="285" mass="32235" checksum="B15A08B15DABAE22" modified="2018-11-07" version="1">MLRPLSRTLLLPPQCRRRIPLKAPLLLRRKYHEVPILQHDFSNGLDGFMTPEGFELAWTLNQTSLLSKLNAMCETENSAFSGMQIKTIILETARSPRYAPIFNHASMAHNNHFYFNGLSPVPAVPIPPVLQKELENSFSSIDSLFKEFIYTAAAMFGPGFVWLVKAGSCDYRILTTYLAGSPYAGAHWRKQSTDMNTVAREGTADPHLQRTWSSKNRDKTLPPGGIHVNPVLCLNTWEHAWLYDWGHGINGDGGKVNFATNWWTYIDWERVSSLSNLNKPEFKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMQ2</accession>
    <name>A0A367LMQ2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMQ2"/>
    <dbReference type="OrthoDB" id="5204927at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="391" mass="44210" checksum="AAD4926216CB71DA" modified="2018-11-07" version="1">MTFTWWPVGAPASKLATDRHHQRRYPNQLTEKLRLLSVPPEGPTSYPLSQPCDPDQLTKKLRLLAAERRGHNHHHLTSSPPPPPPTTTTTTTTTKKRREAKQQHKVKLHRMSAPVQPRDDAAAAEDDSVRSPATYRHIPQEAASQFVRTTTVQPDNNRLSYRLSRQVSISRPDALFASQYGNVSQCELGNTSLLLTEPSSCCSCPKHHPLDSRPRSVIQVTEPQSLSRRRSTGAILARSSFLHNGQPLDPSSSLAPVQECQTNHHRPVDWTQSDESCIQSTTSAVSSYLVRKQRLASLLRRRLRAFAARSKDREPTSEHMKERASSNTSRAGIFARFKPQLAQVRLFQQYEWPIYVCLARMWPRHDRIMIFPPLGPCSTTPPPRALGNRQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMR7</accession>
    <name>A0A367LMR7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMR7"/>
    <dbReference type="STRING" id="1330021.A0A367LMR7"/>
    <dbReference type="OrthoDB" id="73168at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031207">
        <property type="term" value="C:Sec62/Sec63 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018624">
        <property type="entry name" value="Sec66"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09802">
        <property type="entry name" value="Sec66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="102" mass="11624" checksum="CBAA295EAAB1A771" modified="2018-11-07" version="1">METGQVDDDGANVQASQVPNWGPAIFQSANEIITNNRLRDKVDEIQLQMRAEKQWWERRRGQIRTEFMKELDESEKSSSKATSEDDAVVIDTPGKSGKKSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LN67</accession>
    <name>A0A367LN67_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_2711</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LN67"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI15884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="146" mass="16072" checksum="08D957F093469618" modified="2018-11-07" version="1">MKAWMSWRHGRYGSLAGGLFHLLSLEGVSISYRAMGRLRKVVGGEGGEGEAIDGLLAGPPVYAVGREHLLDAVSYRPFGHVREGVCVLPAREGGNPGEVEWMMPSVEMGWWKMGWFLKMEMEMEMEMEMVAAGGERAGADTRNLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LN85</accession>
    <name>A0A367LN85_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_1767</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LN85"/>
    <dbReference type="STRING" id="1330021.A0A367LN85"/>
    <dbReference type="OrthoDB" id="4927525at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09272">
        <property type="entry name" value="RNase_HI_RT_Ty1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439">
        <property type="entry name" value="GAG-POL-RELATED RETROTRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11439:SF438">
        <property type="entry name" value="REVERSE TRANSCRIPTASE TY1_COPIA-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI15906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="123" mass="13388" checksum="BD06919DB334BA67" modified="2018-11-07" version="1">MLPYCRKGLVNPGPQHLSAAIQVLEYLNHTDDLSILFSGHDNSIIAMSDSSFGDNHDRKSTHGFVIRVFGGVVAFKSGKEDTVTTSSTEAEFLALSRVVKEDSSQAMMSRSNVIISRPSGIMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNF2</accession>
    <name>A0A367LNF2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nucleoside transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_2198</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNF2"/>
    <dbReference type="STRING" id="1330021.A0A367LNF2"/>
    <dbReference type="OrthoDB" id="46396at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034257">
        <property type="term" value="F:nicotinamide riboside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002259">
        <property type="entry name" value="Eqnu_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332:SF88">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01733">
        <property type="entry name" value="Nucleoside_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016379">
        <property type="entry name" value="ENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI15965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="444" mass="47341" checksum="210A34470C5ACB95" modified="2018-11-07" version="1">MDRSRAAYERLGDDDDVDDDGVLARSALVDGPPFSWLEYIIFGFLGVAMLWAWNMFLAAAPYFSSRFAADPWIEANFQSAILAASTLVNLGTLVVLTNLQREASYTFRINLALVINTVVFVLLTCSTAVALDASPAAYLVFLLIVVAAASWATGLSQNGCFAFAASFGRPEYTQALMAGQSIAGVLPAVAQVATVLLFPPKHHANNADHVPSKAQTSAFVYFLTAVAISVSALVALAALARRHRGGIVIGSSMAASVASIQEAERAARKVASLWHLFAKLRWLAVGVALTFAATMFFPVFTTKTLSVHPDAAPIFRPAAFIPLAFVCWNLGDLGGRVLAVLPFSLKHRPFALFLLAVVRLAQLPLYLLCNIGGRGAVVSSDFFYLVVVQLLFGLSNGWLGSSFMMAAGEWVDAGEREAAGGFMGLCLVLGLTLGSLLSFTVSDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNH4</accession>
    <name>A0A367LNH4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_1743</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNH4"/>
    <dbReference type="STRING" id="1330021.A0A367LNH4"/>
    <dbReference type="OrthoDB" id="3903189at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF110">
        <property type="entry name" value="UBID FAMILY DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="25"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="278"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="335"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="303"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI15996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="416" mass="45940" checksum="7E1AEF0229B28774" modified="2018-11-07" version="1">MELTTSLAVESWILCALGVVVVGCRFVSRRIKLGKWRELKIDDYLMVFALINFTGVAVSINEVAKNGSNYMKPEEAAALSPEGVQMAIHGSIMTFVLEIFTLTATWTVKACLLMLYARLTRNTMTRQHSLVKVAAGYCALTYVVVTVMFIFFWCRPTYEYWAVPVKIMQCATYYNHMIFATACNISSDLLLLFIPIPIIIKTRLAAKRKAILCLILGLGVFNILAAILNRYYNFSTPNSYVFLYWYVAEVGIAVMVGNLPLCWPILRLLLGGGRSDNSNKTPSYHGETISGNNRRKRRRDPLGTVGTTVTGTTNWDKLDDQECCAAANLATTTTAAAGSDASQRTRRPGSDEGGDEEGEDQGSQIELMLQGHKHNLQHNTAVSVEEGVTEVDQKADDLTTVTVTRTVDVSSEGGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNP3</accession>
    <name>A0A367LNP3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">mRNA export factor GLE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Nucleoporin GLE1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_2072</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GLE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNP3"/>
    <dbReference type="STRING" id="1330021.A0A367LNP3"/>
    <dbReference type="OrthoDB" id="420884at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.510">
        <property type="entry name" value="GLE1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012476">
        <property type="entry name" value="GLE1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038506">
        <property type="entry name" value="GLE1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12960">
        <property type="entry name" value="GLE-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12960:SF0">
        <property type="entry name" value="MRNA EXPORT FACTOR GLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07817">
        <property type="entry name" value="GLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="222"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="101"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI16056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="564" mass="61473" checksum="21A83A659D40C066" modified="2018-11-07" version="1" fragment="single">TEDRKFVSAIPTLDKAILGPGQSPTPVKSTTLFSLCNQPVQSRLRKCSHHRCSMSRSSPDRSPSSFLALERNSQSSLLDALSAAQAEHDRVRETAIRVYELHELKEEHQRILDRERREEERLRAEAEVAAEARKLQELRAKSIPKPAPLPVVAPEPVQTHGQEEPVKARLQEKPTQKPVEVNFPSVRVFPQQNGQQTRPVVGAPTALSAQKAFANGVNTVVKPGAPPNPPPLPQPFNGPKTASPPKPSADRLVQIHRELKLLRSDLMAQSKVAGSPLKGKVGSLRREIRVAVGQLTAGKGANAQPTSKITGLLRQVLKGEIPSPPVQVSRFVAEPSEPVSGSRTNDEALPSLFIYLLNVCAKGIINQFINECGANPKAADPIGVFTAHLFSQPDFQWRGKSLIDILLAKFRIVCPVLFGSRGNDKTEQGRTALGWRKDGPAWITEQNHNDRMAGLGAGFAAISLRDFSKTSKTNPYPPSHYWKAFSLIVNTPATKTSNTQCVVLRAMIDGHDRRFIDLYGNAAIAALRLALVDFPQKAPPNSPAAGSLRALAEVLRAEKGLILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNU5</accession>
    <name>A0A367LNU5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_2073</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10031156at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022155">
        <property type="entry name" value="DUF3684"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019315">
        <property type="entry name" value="MMTA2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058210">
        <property type="entry name" value="SACS/Nov_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF047352">
        <property type="entry name" value="P_loop_sacsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47839">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G04830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47839:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G04830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12449">
        <property type="entry name" value="DUF3684"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10159">
        <property type="entry name" value="MMtag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25794">
        <property type="entry name" value="SACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Multiple myeloma tumor-associated protein 2-like N-terminal" evidence="2">
        <location>
            <begin position="11"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Sacsin/Nov" evidence="3">
        <location>
            <begin position="174"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1575"/>
            <end position="1625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1640"/>
            <end position="1676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1581"/>
            <end position="1598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1653"/>
            <end position="1663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI16057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="2000" mass="220946" checksum="63A0C08E7C9802F6" modified="2018-11-07" version="1">MDLLPSIRKTGSRGGVNFSWDDVASSVHRENYLGHSLKAPVGRWQRGRDLNWYANSNSTPADSTETDEERQQREQAEELRKIKEAEEDAMARALGLPPPQRDTTGANSIEIAPQRGNDALSGEEAEPTKRRRRQLKDAILTKINSMAMDYASLRAAALRSGEEEEAVTVDTRALIDKVLARYSGEWTTLRELIQNAADAQATTVTVRWETLPSTQVPLPSTPNRSELLKHAVAHHTLRRLVVQNDGQPFTKTDWGRLKRIAEGNPDETKIGAFGVGFYSVFADCEEPFVSSGSEAMAFYWKGNSLFTKKSQLPPEKASPYTAFVLDYRNATTPLPNLLSVSQFLATSLTFVALQNIDFFIDDYQILSLRKKSSPSVELLLPRDLEARTKDGLMKIAGVHRTSSQIDASYMSAIAFRPKAAASASKSVESYGSSSETPSLRSFFARLTSSASQSGIRSKSHSEESVVQPKVAEDVTKMNSSAIFLQATSASIATNVTAAFASELERATKKPPPKTTRLSILTASFHEMQASEASATDGVLNKAADVFASVLPGRKPGGRIFIGFPTMQTTGAGMHVSAPSVIPTVEREAIDLNARWVRSWNVELLRAAGIVARLAFANEMEQLDSRLRASGSTPLTERIAGFMPEALHILKTFTFGESTPNGQVGQITEEAFWTCFKKASIETYSSRGVLQTTQVRLGSGELSSFVESIPVVPEELKESPFIKKLIDFGLICSITISDVKKELEAKALTKTQALKFLAWIGNKSLSGELDPGSRSALLEVAVATARDDGEQGEIIAFGSIRNFQNVSKIPAHLPTPPTTIPFAFTANSSAAELQALGWEPLEILAWLRFLIETSRSGPEEQSMTRSANFAVQVLTVLSKNWDLTKLKNREAIALLVRDHPIMPTKMGMRVPEESFFPSVKLFDDLPVIQGCDKLKEKFLTAVGVRKTVDLDTIFTRLLSAPAAGGVKKWSHMELIKYLASVQNDIPSDDLKKLRQSKICPAEAGPPGMEPTKSTTALFKVSELFEPSDSLRTLGLPILQWPGPPGSFRSSSPEGRFLNRLGLRTCPSVPELVEMMTSKDEAARKAAMTYFIANHHANNYASFDLSDTNKAILPLQGGGQLVMPSSCFTNDRAAVLGFDILRKDLLVHANKFGVARDPPMGECVNRLLAKPPKDQRTATTLFGYFASRISEVRDGNLAKLRTAPIVPITDRKSVSRTSQKAGQGLLSYISPSQAYLGTSITYGDIFDFVDFGQEANSFLFHCGAKIEPSKPEVANMVCSEPARMLDALQSADKYMDLLKSLAEATNLLSRDRDLWRRMKASPCLLAYKELAVNSKENLLDLDPDEEEEAPIRHYQLATASQIVVLDDIINYRLFKEHLICAPEEDALETFYLQLGAQRLSSLVHEDVRTGSHTANHKEAESLRKHVVERSKIFLYEYSNYRRDAIKHDTKWLEKNLEVQTVRSVALRRSLKNHRQSYTVKRSAAATKEQGSWVLYVSDEGRPDMYQVGQAICQMLLSRPNQQAYLFFEPFLTLDLYGLRARGYNVDRILRAKAAEARLAEEQRQTALEEERKKIREREESWMQQTAAAGQQPGQAVARQPEAPSMPGGWGAPDGLPPPAADSWSNFNKKGSGLLSNLTRRLGLDSHQSEPTNDVEQTKDDGRRPQEAASGGQDEGRVTNPAVVQQNLLNAIKATRAHGSDSVFSQPTVREVKEQATYCDRTAATNMVFAAEASNGIKVFVARELAGASAAALIRAQGASINSFAGLLVEVGGIYSLEPRALHVFYDEAGGTIAFNTGGSIFCNLRFFLQLHASSMGQAAGKAEAGMWWWVVLAHELAHNLVSPHNSEHSYYTESFIQQYMGKMIALTQAWTRRGGGEGEVTTTSHALPPPPPYSKGITAPNMVHRIAFWSFFGAAVRFWQVGIEMRPFFNRESLWAYPVYALGGASFGHWLQGVDDRQRARLEERKEMLLQKRARHALGEDHERDVLAWDERWRDSSSKSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNX1</accession>
    <name>A0A367LNX1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_3087</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activation signal is received. Near telomeres, it may counteract gene silencing caused by the spread of heterochromatin proteins. Required for the RNA polymerase II and SPT15/TBP recruitment to the target genes. Involved in chromosome stability.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the histone H2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNX1"/>
    <dbReference type="STRING" id="1330021.A0A367LNX1"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000791">
        <property type="term" value="C:euchromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000021">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="11">
        <location>
            <begin position="38"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="12">
        <location>
            <begin position="96"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI16133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="134" mass="14984" checksum="88710264B0CE86EC" modified="2018-11-07" version="1">MRHDSCPWPRERVVLCLSTRPFASSNEPSLTRSNPRFLKQNTQNKMRVGAKAAVYVTAVLEYLTAEVLELAGNAAKDLKVKRITPRHLQLAIRGDEELDTLIRATIAFGGVLPHINRALLLKVEQKKKAKALEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LP79</accession>
    <name>A0A367LP79_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_1901</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LP79"/>
    <dbReference type="STRING" id="1330021.A0A367LP79"/>
    <dbReference type="OrthoDB" id="9993688at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23800">
        <property type="entry name" value="UBCc_UBE2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015368">
        <property type="entry name" value="UBA_C_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09288">
        <property type="entry name" value="UBA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="4"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI16238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="266" mass="29705" checksum="C5EEF8420DB37D80" modified="2018-11-07" version="1">MTSSRDRRIAKELADIQADRDNSGVFAVPADGVNLSHLKGTIPAPPETPYAGGTFDIDIQIPDSYPFKSPLMRFDTKIWHPNVSSQTVRFHNARILGKKKKKKKNKKDRLTSCIQGAICLDTLGNNWSPVQTIKTALLSLRMLLESPNPKDPQDAQVATMLLERPEQFAAVAQEWAVRYAGAPKQDLNLDKWKNQNSTEAASKNGDTTRYQGYNKDLVDRFVNMGFDIDAVVEAFTYVGIDHNGGQDYELEEAYMGDITARLLGEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPR6</accession>
    <name>A0A367LPR6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flavodoxin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2299</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPR6"/>
    <dbReference type="OrthoDB" id="3437375at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016826077" description="Flavodoxin-like domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="163" mass="18084" checksum="BB2E9E8846746C63" modified="2018-11-07" version="1">MSLFQLLLALLIPLQLTSSALTPPPPGHPPRPPPAIFILSSTESRWATKAVADALHTLGFTETGPANSYRQIERDDSPAWQRLASSMPHARFILPAAAGAASDHDDVRRFFDVNHPHQLLELFVGTTVPAEQAENWVTLCRFLGLGYSVVERLKLWYFPAVKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQ68</accession>
    <name>A0A367LQ68_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Autophagy-related protein 27</fullName>
            <ecNumber evidence="8">2.6.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">L249_3226</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27 28">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 4/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle membrane</location>
            <topology evidence="3">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus membrane</location>
            <topology evidence="4">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ATG27 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.11" evidence="8"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LQ68"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00109"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003992">
        <property type="term" value="F:N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000004">
        <property type="entry name" value="Acetylornithine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01107">
        <property type="entry name" value="ArgD_aminotrans_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004636">
        <property type="entry name" value="AcOrn/SuccOrn_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018939">
        <property type="entry name" value="Autophagy-rel_prot_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050103">
        <property type="entry name" value="Class-III_PLP-dep_AT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046468">
        <property type="entry name" value="Spt20-like_SEP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00707">
        <property type="entry name" value="argD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002325">
        <property type="entry name" value="PRK01278.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986:SF79">
        <property type="entry name" value="ACETYLORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11986">
        <property type="entry name" value="AMINOTRANSFERASE CLASS III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09451">
        <property type="entry name" value="ATG27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12090">
        <property type="entry name" value="Spt20_SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="17" id="KW-0072">Autophagy</keyword>
    <keyword evidence="23" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="22" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="21" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="18" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="20 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="13 25" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16 25" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="26">
        <location>
            <begin position="1264"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
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            <begin position="48"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
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    <feature type="region of interest" description="Disordered" evidence="24">
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    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1422"/>
            <end position="1445"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="23">
        <location>
            <begin position="1199"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
        <location>
            <begin position="229"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="24">
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    <feature type="compositionally biased region" description="Pro residues" evidence="24">
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00004304"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004358"/>
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    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
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        <source>
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    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00005363"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
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    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012919"/>
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    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00013776"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
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    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
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    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
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    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
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    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
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    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
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    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
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    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="RCI16382.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1987" mass="215214" checksum="28486EE091247987" modified="2018-11-07" version="1">MAPPFDSYDRGSSRRGVWTHWVPLAVTLSAATVGLAAWVWSQRRDDDGDLVEPGLDYDNADYGDNPPYGATSARDDEMGAPGHPPGSGWGARVSGALRRTPSPQQLFDSTGKTVAAGVAAVGKVLASIREEDKAYPENNPWSEEADAKKDRPPAASWNKRRKAVAIVVSADSHAPRDEEEDPSHQHASILSYIPRQNDFFAIKIYVLIYAPELKDTTLETTASTMPPVSLSSSFSNIGHDQAQSPDADARTSPPASSGGSPLFQAIYSEALRLVDKEAMILPFTTPTGHTHILRHIQPEIVYLQESLSGEDGSVITSLQTWLRHDVVLVVGAERGSGGLADRSDAAAASSLSTVYAYMTTGLGEYKGESECDAREGLPWCLRSTTPSMVRTTTTTTTTTTTTIAAVEASGYNVQRGALHLVCETDQSLNQSNMASSSPVVQQQNGSASKTKRPPPLGIPANGTLPLSSSPSPSMASAKKPPLSAKLPPNSAGDRSITASTVRPVNRARREASSQMLGRNSRNSAGIRSASFPADMAVQDSEPLPHVVSDAVILKKHAGRPPSLVVHLHPTHFRFDGQDGMFPFKSPMRIFIEHLRRRTIPHDLLEYFNKANVPFYDGRLIVKVHNYKVSTPAKDVTTTKSSSSTVVPSSIHNYNQCMTPSPYVPFPKEEQATADELSRRGVETKRSGENRKMDEATPAPGSSRDASKAKAASKPTVFTIVLHPTQESLQADLRIKANTPRGATDTRSDGASAVPPSTPLLAPPTPSASNMPPPAKRAKREKMELDASNVHAAEGQILLATAPPLYLQPTKSAEETIALLEALSSPMHSEPPPKPKTRKRTVAEMAADQAAAAEQERYMLILDDRLSNATGSQGAGSTEGDAQTGGATFEPRFERFMVIEDIKRDQAEKKEQERIKQQESDRRAQLQRQQEALQRQQAEAEKARREAAAAAAAAAAARENQMRQAEAQRQAMAARAASNPQNNSGQNTGIPQQHGHAVQNSGPHSGMLNGGPASAQNAMSNGMQGQVQQRYPSQMGQPPASSPVIRQGTPQQPQNMSSPMAGSVPMQQVNSSMAASPPRPSSVVQNPQMSVPMAHNMSARGSQQSHPSGTPRMPHSTPIMTHGTPVNRPAMVATPRMSQASPPPNMMAQGSQMAAKFGGFENIPQDALDKMKQTSLAQAQHVLQRTMAQRRVQHQMFMQQQAQQQAQQQAQQQAQQAQQQQQQQGQQQQAVSVLLLTSPSPMVPPQSWPALLVAVLAPLRGAAMLRCENVRVDGHSFDLSQLGGPHSVVTSRYESIPDAHHNTTYTLDICKPLKKSGKVKKTEECPNGTRVCAIQRFLQGDKNVVEEVVAIAGSLENVGGSQFDFEATRLKTSDSNSDSQKEGLRLVLKGGKNPLVGPVGERREQRAVVEFLCDRNKKGDEGEWEAEDRYDKRAAADDDKGNKDQSAIEHQLKKEGAALVWESYGREKEADVLRLTWHTKFACEKRDGNTDDGKSSSSHWGFFTCVFLGVAAYLIFGSWLNYNRYGARGWDLVPHGDAIRDMPYLFKDWVRRVLNTRDASLPNPDPRPDSATAALVADHGPYMVATYARPPPVFVRGQGSWLWDVENRKYLDFTAGIAVTSLGHCDDELAAIVADQAKTLVHASNLYYNPWTGALSRLLVEKTVESGAMHDAKAAFICNSGSEANEAAIKFARKAGKVADPSGDKCELVSFDNAFHGRTMGSLSATHNPKYQKPFSPMVPGFRRGRLNDVSAIEETVTERTCGVIVEPIQGEGGVQPASDDFLKALAKRTRDVGAVLIYDEIQCGLSRTGTLWAHGTLPPAAHPDMLTTAKALGNGFPIGAVLVNGRVDGLIKVGDHGTTFGGNPLACRLAHNVVTRLSEARLQRGVVAKGELFRRRFDRLRERFPSLVGETRGRGLILGLQLRGDPGAVVRAARERGVLVITAGTNTLRFVPCLTVGEEEIGWGMDVVEEAIAVVTRGEEEEEEEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQE2</accession>
    <name>A0A367LQE2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HIT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_2233</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQE2"/>
    <dbReference type="OrthoDB" id="18412at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23024">
        <property type="entry name" value="zf-HIT_ZNHIT2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="3">
        <location>
            <begin position="63"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI16607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="256" mass="28389" checksum="81B3347DF08EC86B" modified="2018-11-07" version="1">MVSPDPLIKRESPDTPIKEQSRSPLSLANHDDGKASTPQLEQTESAPREDKSASPKPKGPVICGICTTVASKYKCSRCYLPYCSVACNKMHQMNHPPDPKPEPPPTPPRPSQSPAEPTTACSARHPFQILATSDKLLWLFSKYPKLPQQLLDIHMETQPPAEDASVRIPASLRQRMPARGNWSHEKGIRKGKAALRRARQLPGEAGEAVREYCLLVLLLVEENEAKNGARTMLQQQFAQQDADLIRQLMEMEKGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQJ6</accession>
    <name>A0A367LQJ6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQJ6"/>
    <dbReference type="STRING" id="1330021.A0A367LQJ6"/>
    <dbReference type="OrthoDB" id="3350591at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022085">
        <property type="entry name" value="OpdG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053204">
        <property type="entry name" value="Oxopyrrolidines_Biosynth-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797:SF4">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38797">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP85-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12311">
        <property type="entry name" value="DUF3632"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="291" mass="32001" checksum="C8C38E5DD0476FCF" modified="2018-11-07" version="1">MASTRPPPVDLSGLTSSTSPSSSSTEAAPSSHEAVILRSLSATVNEPDTTASTAAESLDKLYPASADDVGAVEDFLWSFWSLLVGTVKKIPADDERQKLLVDVVASLRRRRDQEVELWGQKTRVWTELPMLGPCMRDAWNLRPKLDGSDKDDAAIREWTSLNSFAARMFGADLQPWVNLAIWELRAALEEAPPSTTTARDAAIATVCEWIAHAGQQLHRQGLEPRTLDAMEERALKPGKLFQGGDSGLSQARWRFWRERLAELGRDAGSAELRKRAQTAATQMEELESSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQZ6</accession>
    <name>A0A367LQZ6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DUF3955 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_2041</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQZ6"/>
    <dbReference type="STRING" id="1330021.A0A367LQZ6"/>
    <dbReference type="OrthoDB" id="4521223at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025016">
        <property type="entry name" value="DUF3955"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35, MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13127">
        <property type="entry name" value="DUF3955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="538"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="562"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="593"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="632"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="666"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="722"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="759"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3955" evidence="7">
        <location>
            <begin position="414"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI16876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="790" mass="86099" checksum="DCC234B3D9BDA108" modified="2018-11-07" version="1">MASLNFTETRDGLPAGSAPNTTSPQIPGQDVPTGTFPQQAVPMFTSQLELTNFCNDNPEVIPCSQLPGLYQYKIDVAPNVIFLFIFCVSLLWYGAVLFRTKRGLSFSLAMMAGLICEIMSYSGRLANAHNQWNLVAFVMEEIFIGLGPTFMAAGLYLCLGNIVAIFGADNSRIPQAYYTRIFIPGDMLALTFQAAGGAATAKNVLSGEPSETSNRVLIVGLVFQLMTLSGFIAASIDFAFRAHGRWKRLGEAAFTQHPAYVRLRSTKRFRGFIAALTLATACILWRSIFHLIELSEPIPGPIRGNQGLFIAFEGLLIVIAVLSLNIFNPVLFYQPVDRPAPVITHEVSDRSRVMALSEMPDQRLSRRLSDAAAADAAAALAPASRVLSPAETAAAAKEDRVRLLPGMGLTRRALGICLLLVTVFLWTITDVVMQFIFSDHTYDKPFFLVYINSSVFAFSLSPMATRYLLKNGLTGLRRDLVRLWRERQLAGTKPKTEAAADEEETVGERLLVEDEAAAEQEERPAPSTAAQKLGMRETAVLSLEFSMLWFAANYLASACLGFTSVASVTILTSTSSMWTLVLCAVYGVEHFSLRKLVGVTASMAGVVLVSTVDLSGSSDANRGSFPHKTAGQIAVGDAMALGSAVVYGLYVTVMKRRVGREDRVDMRLFFGLVGVFNLVLLWPLFPVLHWTGVETFAMPPTGNVWTVIAANSLSSFISDMCWAYAMLLTTPLVVTVGLSLTIPLSLIGEMIQYGQYSSWVYWIGAGIVLVSFVFINSESQEEGGEGKEMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRA1</accession>
    <name>A0A367LRA1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CWF21 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_2987</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRA1"/>
    <dbReference type="STRING" id="1330021.A0A367LRA1"/>
    <dbReference type="OrthoDB" id="10267305at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21372">
        <property type="entry name" value="cwf21_CWC21-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051372">
        <property type="entry name" value="CWC21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013170">
        <property type="entry name" value="mRNA_splic_Cwf21_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562">
        <property type="entry name" value="SERINE/ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562:SF5">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08312">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01115">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="CWF21" evidence="8">
        <location>
            <begin position="54"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="92"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="139"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="109"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI16941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="164" mass="19081" checksum="520B620C33E4D07C" modified="2018-11-07" version="1">MSDNVGLSTPRGSGTSGYVQRNLAHVKARDYGAPYPKDLDSLRYKQRQPDKGILEHDRKRQIEVKVFELRDELEEKEVAEEEIERRCDELRQKLNAESESAKNSGSRRAFKEHQVHEMADAKIKESERLRRALKISADYQEGSHWDRQADRMREAVKDEGGDKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRA3</accession>
    <name>A0A367LRA3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_1751</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRA3"/>
    <dbReference type="OrthoDB" id="5051687at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI16949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="127" mass="15116" checksum="631C750584939071" modified="2018-11-07" version="1">MFLNPSCPEDWTAWWNDVVDTAKNYEVWDFIDPEGDSVLEEPEEPAFPFRATTTRSESADGPSYTLLLQEYEYILLPRYNRRMKKYRKQKKALQIMNTYIRDGAAYETSFYNARTPREKLQELKLRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRU4</accession>
    <name>A0A367LRU4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_1866</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRU4"/>
    <dbReference type="OrthoDB" id="3594971at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI17138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="510" mass="57595" checksum="126A20BDFE32350D" modified="2018-11-07" version="1">MGTSQPLFRLSSEILALILDQLRAVDHRSVFVVRLVCRILDSLATPVAYRAIQLNHRIIHPSASSLYPGLLDHVSCFTHEVTVRSDLPSTDVRRLLSVIERLSLVRWSFVSRNNSDLRLPWDILDADQVERSGTSVAVENLPLGGANCDLDESCFISPALTRRMVSLKLSSPKPPLTTRSGSVKRLVLQSPHLRTMHYRDLGIGTSFSFGGSERLPAVVDLVLQSYNWDHSADEVVRHWDFSRIRSLELVNMPVANFLASVRLGDFARLHTLRVEDYGGHLQETRPGATLRLCELVRDHVEALETLDITCHTQLFELEAIGRHQDSLRVLRYRDHVGFDDDNKRCPTLARSELTALGQRLGHVHTLELDMDDDDDDAVVEAVLSSFDGLHTLTLHVQTRIRPGNAVEPDRDRDREAALDVFGRLVVGRRRRRRPWRRVTINVGGWRRAMVRRMGHGWKRHNEQGVYAERCFWLEADGRGGYSVGEETALGGAICMPPASWRSVRFVAGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRZ9</accession>
    <name>A0A367LRZ9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ima1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_3177</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRZ9"/>
    <dbReference type="STRING" id="1330021.A0A367LRZ9"/>
    <dbReference type="OrthoDB" id="5966927at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034506">
        <property type="term" value="C:chromosome, centromeric core domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034992">
        <property type="term" value="C:microtubule organizing center attachment site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071765">
        <property type="term" value="P:nuclear inner membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042321">
        <property type="entry name" value="Ima1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018617">
        <property type="entry name" value="Ima1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28538">
        <property type="entry name" value="INTEGRAL INNER NUCLEAR MEMBRANE PROTEIN IMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28538:SF1">
        <property type="entry name" value="INTEGRAL INNER NUCLEAR MEMBRANE PROTEIN IMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09779">
        <property type="entry name" value="Ima1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Ima1 N-terminal" evidence="8">
        <location>
            <begin position="10"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="422"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="524"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="653"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="428"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="528"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="539"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="550"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="667"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI17224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1041" mass="113928" checksum="D86DE66D9E4D3DF5" modified="2018-11-07" version="1">MERFRATRYLSCFYCGRRSGLKNDGNTRDFVCLHCDATNYLDERGEITDPPVATDREATTTKLFTAPKPLPASTDSIFCTTCLKNQYLLTSSLAQYLPDDPSDPDYAPLERNYHRYRRGLEKRYPQVCDGCASRVEARLRQAGYAAKTDHLRRMMELGRGRKTASANTALDWVDCLGGLVWAAGFALQLLWHLVAVAPLLRDAGDGLRDPDEAGLAVVATTWLGRLASVLPAPELLVRWSVVAAVVAAWWNPYFVQLFRGFTRHLSGFSRWYSFQGLLVVARLACWSLAGVEGHSRQALLSLHMAMATVMILMYFLAQRSIRVDTSPLFGVENHKEEAALSLVKSKDEAPKTLSDMLTDALEAAPGSPCRQEQSGADPYQPLNRLARNPKPSAAAGGSVCRGDGLVADPAAASRLCAQPSPRKIMSMPDQQTTTQGKNPFWYKVPAAPSNPARQLRNPRRAADPVTKPAVEEADGFTFFPATTREKKGRSRKSDGVEFRQPQFFAPERDDASSLADLLGQSFSLSQEGDQDGDEEGDDGDKQGRIDMRQGKSKRGSHGGASRRHLRLLEPMTLVGLPVLWALTLIFAVPFRNELQTALITAAGVIAFFGAGEQRNGSAAGQLLAAWATAELAASCWRAVVVWLRRADVDGRSRGTETARVDGMNGKTGERERASQGVEGRRRTPPLSCRRGSSGRAKPSSRGWNTKSLDIGGMPHADKVEPTIAGVVLRVNDGRLKPSEVSLLRVSYPTEPLDRLRERYKTEGYVFLKGLLPREDVLKAREAYFTSVSSSGVLKAGTRPVDGIFDSDASAADFPGIGAASVANSRPGSTPAAALFVDLALAAHTSKWYAGSEDDDDDGFARHPALRDFVAAFSGWGGRTLGVRRSLLRNNTPGNGAIGVHYDQSFMRYGEPTAVTAWVPMGDVRLEGGGLIYLEGGDALGQQFEADFNKRAKEAGMSDEEMRSAFNAHMMSSGFLSNGPAEFGREHGRRWLVAEYEAGDVVLHRPHMIHASTINDDPDGRIRLGTDLRQRWNKHFRFDDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LS63</accession>
    <name>A0A367LS63_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_2148</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LS63"/>
    <dbReference type="OrthoDB" id="4664297at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2970">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016810807" description="Secreted protein" evidence="2">
        <location>
            <begin position="27"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI17249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="22584" checksum="4012E27A36107E5C" modified="2018-11-07" version="1">MTTVSARFVSCFLLLVSLLVSLQVSALDDNNNNNNNNNNNNNNNSSNVSTSTTLNNLVLTLRQTSLSPPTVRATVTNKNAHPVTILSYQSPLDDLALGLGLLTITPQRSTEPVKLPIIRVKRVWPPREDSLIVVKPGASATRDFALEEPHVPVQKLGSSATVLLRGQWMAVWPRSREELSKADIENASGTALSGEYVSNSLKVAIMVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LS74</accession>
    <name>A0A367LS74_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LS74"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="297"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI17259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="350" mass="36054" checksum="0FAC1720B27C1E1F" modified="2018-11-07" version="1">MTDQTTENNAAEGEVEARAGARGEWAGEAVVPDTVCPAHIFSGVDAGQEVEVLEVESPAEEAADGQGEAEEAGEDGGENLGGAHRVKALVVPGEVRDAPCVLCLTGGLECRIQAGSTRAFSCAEAAQSGQRRKDAEHLRRLMKSVTTTMRHIGLLEAAKYLPAGTTYQALSGAELVADDDDDTTAAGAAAATILAAAGAAAASIPAAAAANDDDDEDDDDDSDEEESDDDDDDEADDDNDHDAPGLSAVVRVFRGWEGRLAAVEARVDAEAAAFRAELAAAAAKKKMKNKRKKTTKTKTPTTATPTTPTKNRRGAAAATTVTPTTPTKTPRKRAASAAAGSAQKKAKKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LSD4</accession>
    <name>A0A367LSD4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_3152</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LSD4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI17270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="91" mass="9955" checksum="F9C09F907CAC1C3D" modified="2018-11-07" version="1">MVTRAEELKEPRLRIICLAYPLGDVISVPSQGIALQLKAARRGQLGADEYHDGHVEAWKGGVGERQRDNIPITIAERLSGTDTVAVSMQCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LSE7</accession>
    <name>A0A367LSE7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_2511</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LSE7"/>
    <dbReference type="STRING" id="1330021.A0A367LSE7"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI17338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="163" mass="18293" checksum="D50815BF0A71C740" modified="2018-11-07" version="1">MLDRCGGWKGRERVYASGYPGKKLPVSSAYRPGSSPFPRRLACCLLPAFFFHRRPVPIKILMNTNMYIRRKSITIFEYCHVICSVYNLETRSGFNVSEVWSNWVAPGVELGGVGRQIGHYVVEEAPGDNLSQLKALTDRLGVEQKFGSADADSVCTKLEQRAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LSE8</accession>
    <name>A0A367LSE8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_1694</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LSE8"/>
    <dbReference type="OrthoDB" id="5264002at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI17376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="92" mass="10366" checksum="C58E14069C551D87" modified="2018-11-07" version="1" fragment="single">MRYNVLVRASRRELIIYSADNLFLATSLCEISLALRVTPTPKAPPIISLPSKVSNFANLFSKEKASALLPYYSSQDYYIYLRYNPDSSSPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LSJ9</accession>
    <name>A0A367LSJ9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_2899</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LSJ9"/>
    <dbReference type="STRING" id="1330021.A0A367LSJ9"/>
    <dbReference type="OrthoDB" id="4151048at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15486">
        <property type="entry name" value="ZIP_Sip4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052783">
        <property type="entry name" value="Metabolic/Drug-Res_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="66"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="190"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="190"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="231"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="305"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="352"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI17413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="492" mass="54837" checksum="0959C65ADEC33DE5" modified="2018-11-07" version="1">MGSQSLPSPPAEDNKPGLGRKGTAPASGASSKAKNGYRVGKRPYPISSPNNDHVTMDGRHKRVWKACERCRMKKTKCDGEFPCKRCKDDGMVCTAGSRKKVEYKQLPKGYAEVLENTQFALIGTVHKLYNMVRTGQTWDLGEPDLNDRGQPVIHNIAQRLGCIRPNSDLDLPPHTVFPENEADMQELARQLGEQQQQMQSQQQVQQQDQQPQSHHAQPHGHPIPQHVQVLPHHHHHHHHHHPHPHPQQQQQQQQQQQQHRKHHGQAERPSSFSGFNHVERDSSSEQEPSDSELDYQQHHQQQQQQHHHHHHQHHQQQQQQHHHHHHHQHRPSMLSHDFQHTTPFGHVPPDISPRASTSTATPTDFDISPTTAPDMDAGLFGAPTTQSPTVPGPAGPFSSLWDLGKNHAPTDVTTMQFLQEATMAGHGGADGLGGPPPAGHAVDELGQALVQPDFTAAATIKPECLSRSSLSDGMLGIADPMMPGFSDESMQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LSK4</accession>
    <name>A0A367LSK4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">UDP-N-acetylglucosamine transferase subunit ALG14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 11">Asparagine-linked glycosylation protein 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">ALG14</name>
        <name evidence="12" type="ORF">L249_3171</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. Anchors the catalytic subunit ALG13 to the ER.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 11">Heterodimer with ALG13 to form a functional enzyme.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the ALG14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LSK4"/>
    <dbReference type="STRING" id="1330021.A0A367LSK4"/>
    <dbReference type="OrthoDB" id="17098at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043541">
        <property type="term" value="C:UDP-N-acetylglucosamine transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004577">
        <property type="term" value="F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013969">
        <property type="entry name" value="Oligosacch_biosynth_Alg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12154">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12154:SF4">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE TRANSFERASE SUBUNIT ALG14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08660">
        <property type="entry name" value="Alg14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI17222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="270" mass="29810" checksum="98672B2439907805" modified="2018-11-07" version="1">MDASATGPSAITGLVRPSSIIVTTCFALAVAMAIFVTTRRAQLVRQRRAIRWPQTGSTVVQPQRPDSYYLFVLGSGGHTKEMLMMMDDGFCDFVGFHRRYLLSSGDRVSRHQLEDYETRLASLCRAAGTSPGTYDARTVARARRVHQSLLTTPLTALASVIGIFTVLLSPPARARRLRYPMLVFSNGPATGFCVAFAIHLLKVFCVVPEDVMRFVYIESWARISTLSLTGRLLLRSGFADALYVQHQELAAKYGLPCAGEMVLGSRRPDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LSL6</accession>
    <name>A0A367LSL6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LSL6"/>
    <dbReference type="OrthoDB" id="5423926at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="920"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="328"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="358"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="477"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="560"/>
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        <location>
            <begin position="598"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="626"/>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="688"/>
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        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="760"/>
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            <begin position="811"/>
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        <location>
            <begin position="1015"/>
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    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1046"/>
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        <location>
            <begin position="1092"/>
            <end position="1106"/>
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        <location>
            <begin position="1120"/>
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        <location>
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        <location>
            <begin position="1262"/>
            <end position="1273"/>
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    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI17408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1322" mass="141174" checksum="00C953A5DA45DEB2" modified="2018-11-07" version="1" fragment="single">KNCRMLTMPFPVSRQPLTWETAAPDAANAAASAFRRREATLSLSNPAAAAAAALRARPMTSTNVSSVQPKRAVAHRRSPSVSSLIGRERLARRDIHRSPSVSSMVERSFRSPSPGAGQSPMPLATDAPPVPKLPSKVDVAPAVKSTKATDGALPLQTQHFRTASQRVKDGRLGSWFGGAITRDGSNTRKRSSSVTVSGSGTLDGGASAPSVNARPDSVVRANSVLATTTPPKAVNDKPVSEKPVREISSRRLLPRRQLLSRSQSVRETPDKPQKAKQDLSRAGSHLSRGTTDRTRAPTVQSLRSTPAQQEPPAVSSVPQPTEPTDLNKKKKKKKKKKPASKNEAPSETPVAAEEQTAPDDSQTTSSDVKTAPGDSQIPLSDKPPVLELAFSFSGDDETPQPELREPDEVTIDGAVNGRAKSPPAAKRQGRARVAREPSESPARSARFAGTTTQPFIMHEPPARSVSPMKSALKHLHPKDADESDTSDREQFNEDTVAVAPTKKSARVSWDDHTVVVGEPDSLDDKETEKPKLSDVRGQQKSVVEDETMSPRPALPLFGSVRDKKCRDVEERPLVRPAERTRSSQPASVTNPMAGDPDPTSTAEAQEQASNKTTKNYGESLAAATSRVERDAVAKNHEYEDDLESDAETEKGLALDPTPAGLTLPQKSSPLDAEDRRDGSLDTASAGSEADEEFLDSDDVASIEEDPTRLAARSGEAPMGPNSPLMEDIQEEEDETDRCSVYSDACEVLSPMESLDDGLHSSASGNGSSNAKQARSPNDWENAKSYWKSLTPDQRRQLEVEALEDDGDHVQSAAGSSKRSTSSTKETGSERSYQIKPGTRWEEQPPPQQQQQQQQQQPVPVPPTIPQPNSIELPRTAVKPRSEQPGVGLGSPRTVRIGSFEAVWEPKYVEGAQYGPFARFIKGSNKSSSETMLPLKSPRPAASPGAAPAEQERPRNRSVDETASQPVTAERRGSDDSFRRSRVMPLAVDNSPAIRSWMNDQQQQQQQQHNKEQEEMTSSSRGSLSHPTHQVYGSATTAMPPAAVSAGGDGGEEGGGGGGGGGGGGGYLRQSLRGGETAPASAASSPAPPISPGRRRSASRRARKARKDSRLVDSSDEEDGGGGGGGGGGSSHFQSRFDDSSDEDDDDDDDVASSRRRPRPLAKGMAKTMRNSRLSSAISSPSTRPISDAGSSSPPVPAWKREALPPPPSRTGFRHAPTSRRRGSLMSMLFRKMREGGGSNGHDHRRDDNSTNGSSPPCPPPPRSRRPPRRKLPRRQLSPTGALRRGAPGALLVSGPCGAAAVVGDGEHASAVPHEAASRPEAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LSM2</accession>
    <name>A0A367LSM2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Probable aspartate--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="4">6.1.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">L249_2932</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat RAPTOR family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="4"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LSM2"/>
    <dbReference type="OrthoDB" id="10262360at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030307">
        <property type="term" value="P:positive regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04320">
        <property type="entry name" value="AspRS_cyto_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000038">
        <property type="entry name" value="Aspartate--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000514">
        <property type="entry name" value="TORC1 growth control complex subunit Kog1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004083">
        <property type="entry name" value="Raptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029347">
        <property type="entry name" value="Raptor_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848:SF16">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14538">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01547">
        <property type="entry name" value="YEAST176DUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM01302">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="1671"/>
            <end position="1693"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="17">
        <location>
            <begin position="2122"/>
            <end position="2434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="338"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="379"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="429"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1281"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1325"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1776"/>
            <end position="1800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1881"/>
            <end position="1948"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="398"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1336"/>
            <end position="1345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1898"/>
            <end position="1916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1917"/>
            <end position="1928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1933"/>
            <end position="1948"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00070516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RCI17455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="2434" mass="272619" checksum="FBA85DA3DC83F6E2" modified="2018-11-07" version="1">MIEAGDAIYKAQAMCAGRIIHGAGGRLECDEEQSKSRLTRAGLPPLGIPEGGFAALSVQGTTAEGGGLWAVPAADLLYGMHGDASELRPAARRDDAMRQGATGPGMYHMYYMLEVVRIQSHPLSDGLFPLGLEWFVSSSAMILERGTDGYLEFAGRGSGKGGQQSSVDYGTGGCFNVFSHFSQMITGDAPESHHCYGNPASSYLPRYLASGGNDVREKKKRNPRFNPAFTFPHRLLSLAVQAARKTDRLLYPVFHSLVNDFLSCIRSLSQLCPHYDAGVLVLQLSNAGSLQRQIKNQSYPPTCRRLTSYNLRLLPPTLDSTSVPATNTMTVVLTHQTQPPPHDQHLFLLHQPSGSSQTTRPDGLRRPVHGRRAEMTLRSDLLGSSPSAAAAATTTTTNGETSRFATQGNGSPDRHTVLRNGERRALIALGHDDGQPGPSSSPPSPDARDDDLDSDRPRRPAKPQLLRSKSDFVPRQPDEDEPDDEIREWGARHGFEDHYQSEHIISQLVSNWYMYFTDKRHETTGKPKPLDYELQDWRQRDRLKTVSAALAVCLNIGVEPPDQLKTTPGAKLEAWTDPTIPPIQKALENIGKALQSQYETLAIRARYKQYLDPSVEETKKFCVSLRRNAKDERVLLHYNGHGVPKPTASGEIWVFNKTYTQYIPVSLYDLQHWLQAPTIFVWDCSEAGNILTNYHRFVEKHDEEEDEAAERDPHYERVNYRPYIHLAACAVKENLPTNPLLPADLFTACLTTPIEMALWFFVLQNPLKTNLTPERAKQLPGRLQERRTPLGELNWIFTAITDSIAWTTLPRDLFRKFFRQDLMVAALFRNFLLAQRVMTVYGCHPQSYPALPDTHQHPLWETWDLAVDMALAQLPMLERKDSEGVDYDYQNSTFFTEQLTAFDVYLTRGDAMAQKPPDQLPVVLQVLLSQQHRVRALILLGRFLDLGPWSVQLALSIGIFPYVLKLLQSAAAELKPVMVFIWARLIAVDLSCQQDLIKDSGYSYFAQILKPSEGLPVVDSDEHKAMCAFILAMLCKGYKNGQMVCNQTDIMTYCLAHLQNENNPLLRQWACLCISQLWQGLPEPKWRGIRENAYVKLAFLIRDPCCEVRAAMIHAMTTFLGIPDLTDEVARIEESIAWTILDMGTDGSPMVRREFLVFVSHFIIRFENKFLVTAYEQLQEEKDYILFPPQDDGQDHKMGLHYTKPENRNRDGTIKSSAHGLSHNTVYMALWKHALILSVDPHPEVQREATIVVDYVHNALVDSSIGENAQALMKDIQRRAKKATQRQPPREMLRNGIRGVPSTPPMTSPGLLRRTASLLFQSFIGGDDRMSPNGMPSPRQQPPRSVSAKIPADQVSAPPEQNDQFNAPAAYNVAREPLSGAFQERDPTKLPTIPLKSGFLEWSIEYFREPQMKASEADEPGSTEYNERLWRRARNETLLRETQPLKQLAGSHKWNNQLGMVNNGAQPAKMTFHQYEDHLAVSDDGNTVFVWDWKKQGRLSKFSNGNPEGSKISDMKFINEDDQAFLLTGSSDGVIRVYRNYDSDKTIELATSWRALTHMVPSNVNSGMVFDWQQVTGRVLVAGDVRVIRVWYAAHETCVMDVPARSGSCVTSLTSDQMTGNIFVAGFGDGAVRVFDTRERPQDSMVRKWKDESDRQWIKSVHMQRGGQRELLSASRNGKVKVWDIRMDRPLLSIQTTRDTLRTMSTHEHLPVFAVGTSQHTVKVFNLDGRELSRLEPYSSFLQQNRGGPISATAFHPHRPILGCAARGDYHTMVARDAHAHSESESREEEGVARPGMHESTDVACTTINCMGWRLNERAVPVVDEFAVDTWERRSQLMREISTFPKRHARFGRPEHVLIVSSQQPKHRLLKLPVAMADKLPPAAADDGEAGPSKKALKKAEQKAKKEAEKARRAAEHQASQAAAKAAAGNSEDLAKDNYGDVPPETRLESERLHIKDTCDKNVGKTVKVRAWIQNSRMQGAKMAFVELREEGDWAIQGVVAASADGTPVSRQMVKWIGGLHLESFVLVEGRIEKPLEAVKSVRVSGYELHINKCYVVAPGPEVLGMGLVVANKPVTNFDDEEAGVDEAASPADGLPSASMATHLNNPAMHKRAPVQQAIADVRMTTRKLFADYLDSKGFRQFEPPCLIGAASEGGSNVFGLPYFDKKAYLAQSPQFYKQYEIAGGRKRVYCIGPVFRAENSNTPRHMTEFTGLDLEMEIEESYVEVVEMLEGVLLHIFRGLAKQCAEQVALIRTVYPSEEFLLPEPGREVRLTFAEGQALLRAEGPAEFADVSDTEDMSTPQEKALGAVIRRKYKTDFYMLDKFPEGARPFYALEDPKDNSVTNAFDFFMRGQEILSGGQRIHDARLLEARIRKKGVDPASAGIKEYIDVFRSAGVPPHGGGGIGLDRVVAWYLNLPSVHLASYYPRTPKRLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LSU0</accession>
    <name>A0A367LSU0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_2652</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LSU0"/>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000881">
        <property type="entry name" value="ABC multidrug transporter A-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="528"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="560"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="602"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="636"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="665"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="785"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1219"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1252"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1291"/>
            <end position="1319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1340"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1376"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1492"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="161"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="873"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI17469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1528" mass="169623" checksum="54F048FC8CEB296B" modified="2018-11-07" version="1">MYGINTNYDSTAATSGAPIDMPYRAHGYNDDDDDYDDHHVGRQPPPDDLAFSTGSSSPLESAGKPRDAEMIRRSSVVQDLARSYSRASAVEGQNPFFAGLDSPLNPASPKFSARQWARAVAELVTNTGGAFRSAGICFQNLNVYGYGESTDFQKNVANTWLSLAGLFRRFIGSGRQRIDILRQFDGLVRRGEMLVVLGPPGSGCSTLLKTIAGEMNGIFVDGGSYFNYQGMTAAEMHSSHRGEAIYTAEVDVHFPQLTVGDTLTFAARARQPRKLPEGLSRNGFAEHLRDVVMAMFGISHTINTRVGNEYVRGVSGGERKRVTISEAALSGAALQCWDNSTRGLDSANAVEFCKTLRLQTELFSSTACVSIYQAPQSAYDLFDKAVVLYEGRQIFFGRADAARQYFVNLGFECPPRQTTPDFLTSMTSATERLVRPDFKGKTPRTPDEFAAAWKNSAEFAALQDEIEEYKAAHPFDGPDAEAFRASRQAQQAKGQRKKSPFTLSYSQQVHLCLWRGWKRLSGDPSLTIGALIGNSVTALIIGSVFYNLQDTTSSFFQRGALIFFACLMNAFASALEILTLYAQRPIVEKQSRYALYHPSAEAIASMLCDLPYKIVNSIVFNLILYFMTNLRREPGAFFFFLLISFWTVLVMSMVFRFIGSASRSLFQALVPAALLILDLVIFTGFVLPTRYMLGWNRWLGYIDPLGYAFESLMVNEFHNRQFRCTQYVPSAVASRPDVASTLAKYANLRPENQVCSTVGSVRGQDFVNGDAFIRSSYGYEWGHRWRNLGIVIGFTVFFLICYMIAAELVSERKSKGEVLVYRRGHKPAAAKHAERRHGDAEAAMANIGPVITAERSRVGAKEGGILQQQTSVFQWHDVCYDVKVKGELRRILDHVDGWVKPGTLTALMGVSGAGKTTLLDCLADRTSMGVITGEMLVDGKPRDMSFQRKTGYVQQQDLHLQTTTVREALNFSALLRQPAYIPKEEKLAYVDEVIKLLDMGEYADAVVGVPGEGLNVEQRKRLTIGVELAAKPPLLLFVDEPTSGLDSQTSWAILDLLQRLTEAGQAVLCTIHQPSAVLFQRFDRLLFLAKGGKTVYFGDIGENSKTMIDYFERKGGHPCPAEANPAEWMLEVIGAAPGCTTDVDWFQTWRTSAEYRTVQAELDGTKQQKHEGVVETTTTTTTTEAVADPGEYREFAAPFMEQLKENLFRVFQQYWRTPVYIYSKTALCTLVALFVGFVFYKAPVSIQGLQNQMFALFQLLTVFGQIVQQSMPQFVIQRSLYEARERPSKVYSWKVFMLSQIIVELPWNALMAAIMYFCFYYPVGLYRNAEVTDAVAERGALVFLFLLAFLLFTGTFSTFIIAGFETAEGGGNAANLMFTLCLIFCGVLATPETLPRFWIFMYRVSPFTYLVSGMLSAGVANVDVVCADNEVLHMTAPANQTCGDFLGTFAQVSGGRVLNPGDSGGCSYCPLASTNSFLAAVSSNYDDRWRNFGLLWVYIGFNIVAALGVYWLARVPKKSLGKGKKKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KYZ8</accession>
    <name>A0A367KYZ8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4508</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000030">
        <property type="protein sequence ID" value="RCI07405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KYZ8"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI07405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="177" mass="18978" checksum="C5D86C60FC1ED83D" modified="2018-11-07" version="1">MENIEGGTNPDSAAGASTQPNQELTERLQLKRPWADSESEKQDDMVNIKEGMDQMDIDPKTSGTDSENYVLEKQQGEMPDIFGGGDGGWVLTLERLSSFSSSPSHPIPSHPIPAHPIPSHPIPSHPIPAHPIPSHPIPSQPIPSHPIPSHPIPSQPIPSHPIPSHPSPSHPIPSALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZ07</accession>
    <name>A0A367KZ07_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_4504</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000030">
        <property type="protein sequence ID" value="RCI07409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZ07"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI07409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="108" mass="11878" checksum="F07B70BF0D56DBF8" modified="2018-11-07" version="1">MKVELIAAADTDIATADTVGCCWEEQISPGGKFTHDDLPCPPLSDIYESGINKLAIYLQLVMYSTADTVGCCWEEQISPGGKFTHDDLPCPPLSDIYESGINPYIYNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZ66</accession>
    <name>A0A367KZ66_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="4">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_4553</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="4"/>
    <dbReference type="EMBL" id="LKCN02000028">
        <property type="protein sequence ID" value="RCI07473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZ66"/>
    <dbReference type="STRING" id="1330021.A0A367KZ66"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004175">
        <property type="term" value="F:endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02659">
        <property type="entry name" value="peptidase_C19C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.210.10:FF:000011">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000005">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024729">
        <property type="entry name" value="USP7_ICP0-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029346">
        <property type="entry name" value="USP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF644">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22486">
        <property type="entry name" value="MATH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14533">
        <property type="entry name" value="USP7_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12436">
        <property type="entry name" value="USP7_ICP0_bdg"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00061">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="MATH" evidence="10">
        <location>
            <begin position="76"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="11">
        <location>
            <begin position="232"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI07473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1213" mass="140319" checksum="15053E42E04FCFA6" modified="2018-11-07" version="1">MSYPIDSPNEMIMDADDYVGAIDASDKDPVAIISPDNLDQVEAGQQLQDLPLADDHDAMKEIALPPLLDEPKILEDHTFTWPVENWRGLGKKEHGPVFDAGGFPWRILLFPHGNNTDQCSIYLEHGFEPDAVPDNWSCCVQFALVLWNPNDPSLYVHHAAHHRFTKEEGDWGFTRFVEHRRMFNVPWENGSRPLCENDAANITAYLRFVKDETGVLWHNFVNYDSKKETGYVGLKNQGATCYLNSLLQSLYFTNAFRKAVYEIPTENDESMQNSAYTLQRLFYQLQTSDQAVGTNELTKSFGWETRHIFEQQDVQELSRKLMERMEEKMKGTKAENVLPEMFSGKIKTYISCINVDYESSRIEDFWDIQLNVSGNRNLLDSFQDYIQVEKMDGENQYFAGDQHRLQDANKGVIFTSFPDVLHLQLKRFEYDIQRDMMMKINDRYEFPEVFDAAPYLTEDARKSSEPWTYQLHGVLVHSGDLNAGHYYAFLKPEKDGWFYKYDDDKVTRATVREVLEENFGGEYRTPNGYPRAPLQKKAPLMRQNSAYMLVYIRQSKLDKILCPVAVDDIPRHLRQRFEEESALREARRREQREAHLYMVAKVITDETFLEYGGTDLCSFDANPEVDAAAPRSYRIRRTMTMEEFVEQVAADIRQDARKVRLWLMVNRQNKTIRPDQPIMDLRPTVEDVFSRSAAHRDTSLRVWAEVAGEFDAAGEPIWPSYQSQANGGTSKNDIILILLKNFDYAQQRLRGVGHVYINKEKKVEELVPLILQRMGWGEKLPADEKLLLWEVRCPVSNLACGLHDATLTRNRQEIKPTMIEPLKPKQSLKVAELQDGDIVCFQRTTEKADQQRASNKALQEPCVDALPSRSPFLRRKVAASSHVSSRVRSTEHFDDAREHYDFLEHKRTVRFHPHPNRRDQTQYAPFDLVLNAKINYDTLSERVGAYLSVPSTHIRLWTVNATTSNPKAPVRRGTNPSLRQILNPMGSNSLNQAQRNDAFFYEVLEMSLAELDTKKSIKVTWLSDGIAKEDHLDLLVPKTGTIEDLIQALIKKAKIADEAEGGRIRVYESSSNRFYREPQREHPVLNLNEYTQIFAERIPEEEGKAEEKNFIQVFHFQNEVNRVHGVPFKFLLKEGEKFSDTKKRLEKRTGLKGKSFEKIKFAVVRRAHYSKPQYLHDDDELWEVASSEDDMLALDHVDRSRSLRNGVGDLFLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZF3</accession>
    <name>A0A367KZF3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Dynamin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_1609</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000026">
        <property type="protein sequence ID" value="RCI07563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZF3"/>
    <dbReference type="STRING" id="1330021.A0A367KZF3"/>
    <dbReference type="OrthoDB" id="9984778at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008053">
        <property type="term" value="P:mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051646">
        <property type="term" value="P:mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000638">
        <property type="entry name" value="Transmembrane GTPase Fzo1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027094">
        <property type="entry name" value="Mitofusin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465:SF0">
        <property type="entry name" value="SARCALUMENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465">
        <property type="entry name" value="TRANSMEMBRANE GTPASE FZO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="13">
        <location>
            <begin position="286"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="37"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="158"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="501"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="514"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="535"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI07563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="926" mass="101314" checksum="0456222315934B2E" modified="2018-11-07" version="1" fragment="single">APPQPSYKKHNLLASLPASRIVTKHATRPNIVVMSQDYFTGKGKAPARRDSEEADAQQSPAPPNYMTVGTGSTSEHASRLLNMLDIDSGYVGSVSGEEPRAAMARAEAIYHDRPQAGVLHQMWYNSQRATLGRAINKVLDLLQNLREMNTAWPAHYPSVQRDATSERPSSRPGFPHTQSTMEGFGGAANRAQQADSPGPLRRSMTVVEASSAESSRVAESRPVPEPRLVSPQIAQEFSILKLDLKLGSLNQAELLHSLEKGSIASLLDGKISSSMKHLISLRERIEDTSSKVLITGDLNAGKSTFCNALLRRKLLPEDQQPCTAIFCEVLDARANAGVEEVHAVHKDAAYNRNDESTYDVFPLADLEKIVSDNEAYTQCKVYVKDVRTIDESLLNNGVVDIALIDAPGLNSDTTKTTAIFARQEEIDVVVFVVSAANHFTQSAKEFIWAAAAEKAYLFIVVNGYDAIRDKDRCQKLILDQVSGLSPRTFKESSELVHFVSSNAIPAGPSPPGGPEGGGGSSSGGGGGGDPDDESGPEKGKGKDPDKARKFEALEQSLRRFVLEKRARSKLAPARTYLLNILNDVNALATVNHGVAQSELNRVTRELKTLEPQLETSRRAVSEVGDQVDQEVEHVCKDVYDHTRAELNSAITYAGKCNHDVPYPGFLSAFQYADELKEAMLSHIADAVSDCEEYARSKSVQGVNVIKQLGLLHVGDEFQSLQFRPDIMFRRKRDALARQVDVPTELWDFVDWSTLLQRQEKFAGTGMALTLAGAFVPRFVGMSSWMDQALTATRLLSNENLQRLILPGIFVAAIGAAAYVLQQIPNSLPPRLASKISTQLAEIDYVHANSARISSSVHKVLRYPAETLRVGLDQSVKDLGNRLDETVKVKDESERAAKFFRDLAGESQVQRSMVEAVDLDAPPPGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L017</accession>
    <name>A0A367L017_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000024">
        <property type="protein sequence ID" value="RCI07768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L017"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI07768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="343" mass="38958" checksum="CCB888FAD951459B" modified="2018-11-07" version="1">MGDENKGRLYITLADALILFCWRAVFPLYKPAFLNFHLSQLKAKASSKSYTCRRLYLSPCQNIYLSLMFPLVRNERIWMVTSFASLVRVYRSRTFKPYPPTLTLQYESHDMTYSLSSEHLPQTSPSFNKLLVNDISSTPAIHSHPVTTFIRSIVASFFLQSQGLSPPMKEQVLDLENALHCIAVTSPAFSLHARARNEYGSSGLMASSRRNARGILAPASSGTGLHVVSRCRETWNEMYQVSGYTARCYFRMGFIVSGVLFFNRRDCFPAWGPSSSQTSVDVRHNANWFLDSFRFGPSTDESCSEMKNRDGVFSRLSFLIILQRVVIVEKGLRLYGNGKMPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L021</accession>
    <name>A0A367L021_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000024">
        <property type="protein sequence ID" value="RCI07766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L021"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI07766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="66" mass="7124" checksum="51AA76DDA6F660DF" modified="2018-11-07" version="1">MTTTMTTTTTTRLQLCGDAKLRWHSRSMRRWGSLNPLCRVSGAELVPWGGGAVLVLVLVLALPGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L054</accession>
    <name>A0A367L054_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Replication factor C subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_5794</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000023">
        <property type="protein sequence ID" value="RCI07808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L054"/>
    <dbReference type="STRING" id="1330021.A0A367L054"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000011">
        <property type="entry name" value="Replication factor C subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000237">
        <property type="entry name" value="replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
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        <property type="entry name" value="P-loop_NTPase"/>
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        <property type="entry name" value="Rep_factorC_C"/>
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        <property type="entry name" value="RFC_lid"/>
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        <property type="entry name" value="PRK00440.1"/>
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        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
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        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 4"/>
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        <property type="entry name" value="AAA"/>
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        <property type="entry name" value="AAA"/>
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        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
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        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
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            <end position="201"/>
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        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
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    <sequence length="380" mass="42070" checksum="6EFCF485EB80E3E4" modified="2018-11-07" version="1">MASFFDIKARKAAAASASSAGPKSHREVDAGNQPWVEKYRPKTLDDVTAQDHTVNVLQRTLQASNLPHMLFYGPPGTGKTSTVLALAKELYGPEMVKSRVLELNASDERGISIVREKVKNFARMQLTNPPPSYNQRYPCPPFKIIILDEADSMTQDAQSALRRTMEAYSKITRFCLICNYVTRIIDPLASRCSKFRFKSLDQSNARKRLEDIAQVEGLLLEDGAVDALVRCSEGDLRKAITFMQSAARLVGHSDKSGGGHDQMEVDHKPVTVKIVEDIAGVIPNKVIDDLVKAMRPKGKKQAHESVAKIVEDMVADGWSATQVVFQLYQTLTTDESIADIQKNKIVLVFSEVDKRLVDGADEHLSILDLATRISGIMAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L104</accession>
    <name>A0A367L104_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Phosphatidylserine decarboxylase proenzyme 2</fullName>
            <ecNumber evidence="12">4.1.1.65</ecNumber>
        </recommendedName>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 2 beta chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="12">Phosphatidylserine decarboxylase 2 alpha chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="12" type="primary">PSD2</name>
        <name evidence="16" type="ORF">L249_6351</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine + H(+) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine + CO2</text>
            <dbReference type="Rhea" id="RHEA:20828"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="EC" id="4.1.1.65"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
        <text evidence="12">Binds 1 pyruvoyl group covalently per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit. Interacts with pstB2. This interaction may be a means to structurally tether the donor membrane (ER) harboring PstB2 to acceptor membranes (Golgi/endosomes) harboring PSD2 during PtdSer transport to the site of PtdEtn synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Golgi apparatus membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Endosome membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The C2 domains have an essential, but non-catalytic function. They may facilitate interactions with other proteins and are required for lipid transport function.</text>
    </comment>
    <comment type="PTM">
        <text evidence="12">Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type II sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="12"/>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1330021.A0A367L104"/>
    <dbReference type="OrthoDB" id="67700at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00616"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04039">
        <property type="entry name" value="C2_PSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04024">
        <property type="entry name" value="C2A_Synaptotagmin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000445">
        <property type="entry name" value="Phosphatidylserine decarboxylase proenzyme 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000198">
        <property type="entry name" value="Phosphatidylserine decarboxylase proenzyme 2"/>
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    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000295">
        <property type="entry name" value="Phosphatidylserine decarboxylase proenzyme 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00663">
        <property type="entry name" value="PS_decarb_PSD_B_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033179">
        <property type="entry name" value="PSD_type2_pro"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF17">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="3 12" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="12" id="KW-0967">Endosome</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="11 12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0865">Zymogen</keyword>
    <feature type="chain" id="PRO_5023340100" description="Phosphatidylserine decarboxylase 2 beta chain" evidence="12">
        <location>
            <begin position="1"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023340099" description="Phosphatidylserine decarboxylase 2 alpha chain" evidence="12">
        <location>
            <begin position="973"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="20"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="14">
        <location>
            <begin position="246"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="15">
        <location>
            <begin position="496"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="197"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="382"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1033"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="393"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="424"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="828"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="886"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system; for autoendoproteolytic cleavage activity" evidence="12">
        <location>
            <position position="973"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via pyruvic acid; for decarboxylase activity" evidence="12">
        <location>
            <position position="973"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage (non-hydrolytic); by autocatalysis" evidence="12">
        <location>
            <begin position="972"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="modified residue" description="Pyruvic acid (Ser); by autocatalysis" evidence="12">
        <location>
            <position position="973"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCI08108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1083" mass="121692" checksum="B3160AB8E78DB998" modified="2018-11-07" version="1">MRIVPTRLLSSTSSNSNSNSRSQSPMRGKADSAADGLALKVVVMRARNLAAKDRCGTSDPYLIMTLGDSRAVTHSVPKTLNPEWNAIEELPVNCVNSLVLDVICWDKDRFGKDYMGEFDLALEEIFVNEQTEQEPRWYRLRSKRPGKKTGVVSGEVQLQFTLFDTTNLNATPRQVFEKFYRLIGDVNIGSSRTVTPSATPLLAPTTDYGGQDMDEEDNFTELDEEPEGQETAEKRKRRLRIRGLKRRRRQNLYAFNSVSDVVGIIFLEICKVTDLPPEHNLTRTGFDMDPFVVASLGKKTYRTRRVRHNLNPVFNEKMIFHVQRHEQAYSFSFTIIDHDKYSGNDFIASCSFPVHDLIEKAPQADAETGLFWLPTYADAPPRPTRSRFKKLNMSRSSSTQSMGKLMRTGSSRNTASQSSTPEPGQNQSGNGQGLLSPTESMAVSSPAEPSEPSTEGEEPEFHDYVLPLKMKHQEKWEAKHSPAIYLRAKYMPYPALRQQFWRAMLRQYDTDESGEISRIELTTMLDTLGSTLRESTIDSFFQRFPHRTADNEESWNLSMDEAVICLEDQLEPKGKPSVGDKLKGLVSDARNLNLLNRSAEPSGDAHAVAVPEMNAPVEAEAEEDLGDERGEEHLVEIAECPICHQPRLDKRNDSDIVTHIATCASQDWRQVNTVLMGGFVTASQAQRKWYSKVITKISYGGYKLGANSANILVQDRMTGQINEEKMSVYVRLGIRLLYKGLKSRDMENKRIRKLLKNLSIKQGKKFDDPASRDEIEKFISFHRLDMSEVLLPVEEFRNFNEFFYRALKPEARPCSAPDNGKIIVSPADCRSVVFDQMTVATKIWVKGREFNTRRLLGNAYPDDAARYENGSLGVFRLAPQDYHRFHIPVDGVLGKPVTIAGEYYTVNPMAIRSALDVYGENVRVVVPIDSEHHGRVMVICVGAMMVGSTVITRAEGEPVRRAEELGYFKFGGSTVLLLFEEGRMRFDSDLVDNSNGALETLIRVGMSIGHSPDQPQWTPDMRKKDIDITEAEKREAKRRIQGNFASMQESSGDSADESLDAASSSPRTLSSAPTVDTVAGAVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L162</accession>
    <name>A0A367L162_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Delta 8-(E)-sphingolipid desaturase</fullName>
            <ecNumber evidence="5">1.14.19.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">L249_6242</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">BCC 54312</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.18" evidence="5"/>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L162"/>
    <dbReference type="STRING" id="1330021.A0A367L162"/>
    <dbReference type="OrthoDB" id="260091at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016717">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006665">
        <property type="term" value="P:sphingolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03506">
        <property type="entry name" value="Delta6-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353:SF30">
        <property type="entry name" value="DELTA 8-(E)-SPHINGOLIPID DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19353">
        <property type="entry name" value="FATTY ACID DESATURASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015921">
        <property type="entry name" value="FA_sphinglp_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="8 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="224"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="270"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="18">
        <location>
            <begin position="4"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="105"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="112"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RCI08179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="557" mass="62435" checksum="9F6BB91AD65D6B75" modified="2018-11-07" version="1">MNRNQILSQAAIDSRIAQGQTIVIFRDDVLRLDSWLAKHPGGSLAILHMIGRDATDEMTAYHVPATLRTMAAFRIGRKPPGPWINRTPPIRRAPLPCLDATSHLVADQDGDSSSSSSSSSSSSSSSSFSSSSSPSSSPSSSATASTSIPPTDDDGLRKRKTSKDRYVELAVQSAVDKAVSDYPSLNPAVQQSIVAEYRLLHQKVIDEGLYACPYRQYAKEMARYLALFSASLFALHHGWYITSSFLLGLFWHQIMFTAHDAGHRAISQIFVVDTLIGMFIADFCCGLSIGWWKSSHNVHHLVTNQPEHDPDIQNIPLFAICPSFFKSITSTYYDNFVMVWDGAADLLVPYQKYTYYPVMAIARFNLYILSWLHVLSSKSPSLANSKAWWIRPTEVAFMCCYWFLFGYCLLWSSLPTWTMRLVYVLVSHIVTMPLHVQINLSHWGMSTSDLGESESFAQRQLRTTMDISCPPWLDFIHGGLQFQAVHHLFPRLPRHNLRRAQALVRDFCSSTGIPYSILSFADGNRKVLGRLRDVSDQLALLADCQKSMADSGVYELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1R3</accession>
    <name>A0A367L1R3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SPX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_8839</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1R3"/>
    <dbReference type="STRING" id="1330021.A0A367L1R3"/>
    <dbReference type="OrthoDB" id="5588846at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14474">
        <property type="entry name" value="SPX_YDR089W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="395"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="8">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI08337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="420" mass="47087" checksum="720E893693C48B19" modified="2018-11-07" version="1">MKYGQQLEHESVPEWRLHNLDYNSLKHEIKAHTSSLQATPTAIPGHPCKFEDGLYFELDRQHSRLDLFVTSKADEISRRLDHLDADVHRWLRKHADDASPRGQRRLVKYERDLLRCGRDILALSRFANAQVVAFRKILKKYRKWTGSVSLTWRFNQNVLGNPKSFTKRDFEPLQARYDDMLADIRSASVAFFSEPSSPSTDSRSTRKPKVTFDATPPPRFQPQVYWNEYDDGSEAAADDYAIYVNPDDRVAFPGLACVRALTAVPYGKAKQWLDQRRKHTDDSRPLLGTCADRAGGRRYYSSIRREDEVQGYDGIGVEEDAGRDRVLARGTAGCLVASFVLLGLAATLMAAGRSRMRVEVDAGVTAGVLFSLVCACAGLGMALCRRRAPGMLHRVVIWAAFVSSCLCSGVLLVFVLASAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1T0</accession>
    <name>A0A367L1T0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_8965</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1T0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI08368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="76" mass="8577" checksum="E9F0C339F08DAA72" modified="2018-11-07" version="1">MESNEVFCGAMEEEEGGEKLVEIIKVWITIEEELKAGEVIVLKNTTIEVGRYDRYWYSASIAYSAPIDVTAALCRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2E0</accession>
    <name>A0A367L2E0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_4733</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2E0"/>
    <dbReference type="STRING" id="1330021.A0A367L2E0"/>
    <dbReference type="OrthoDB" id="47374at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051556">
        <property type="entry name" value="N-term/lysine_N-AcTrnsfr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42919:SF8">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="39"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="204"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="270"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI08599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="301" mass="32578" checksum="57E92A8989E7F8CB" modified="2018-11-07" version="1">MSLPTSKLPTAQLSIRLFSLQTSADAPLPPSPPNLPSQAGVRLVSAADTAALRRINALLLPVTYPDSFYARAVCRAQSGRFSRVVTWAHDGEEAKVVGGVVCRLESDDEHDSGQRLYIQSLCLLAPYRGKGLMAAALDHVIATATSDAALDVRSVTAHVWTDNEDGLRWYESRGFGRRRQPVAGYYLRLRPDSAWLVHRQLSPQQSPLPQGEDDADLVASRPPPSRTSASTPVLPSSSSVVVAQSYQNQRPDMEWNDLPADMAPGFLAKPSSDPASRAGSRSSSAIRKKRDRSYPAAAFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2L5</accession>
    <name>A0A367L2L5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial intermembrane space import and assembly protein 40</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Mitochondrial import inner membrane translocase TIM40</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_4668</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Forms a redox cycle with ERV1 that involves a disulfide relay system. Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
            <orientation evidence="2">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2L5"/>
    <dbReference type="STRING" id="1330021.A0A367L2L5"/>
    <dbReference type="OrthoDB" id="7481291at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045041">
        <property type="term" value="P:protein import into mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039289">
        <property type="entry name" value="CHCHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21622">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21622:SF0">
        <property type="entry name" value="COILED-COIL-HELIX-COILED-COIL-HELIX DOMAIN CONTAINING 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="96"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="223"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="235"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="262"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI08664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="332" mass="35345" checksum="EE2F856BE4A3C936" modified="2018-11-07" version="1">MFCAAVARSASRAVPRAMTRCGPQRLASTLSPASRSRTIRGSLVRWALALGAVYYYNTSPVFADEVDAEPTIPATSPFPGPEPNTVDAVVEQKRKQARAAVLSDRQQQSSATGAKTEALGEATAPGSTPASEEDEDDGGQGGAFNPETGEINWDCPCLGGMAHGPCGEQFRAAFSCFVYSNEEPKGMDCIEKFQYVRSMQDCFREHPDVYGAELEDDELPEEAAMEAPAAGRNATPEREEPSRDGRGSSVREAAATGQDTARGSDKSSAENEASHVMGEDGKRAKTVAEKDIARKVDADAKPSRYEVTAESHADAPWRDASVTNGADARKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2Q4</accession>
    <name>A0A367L2Q4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4768</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2Q4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="226" mass="25658" checksum="93D05742F194B0D2" modified="2018-11-07" version="1">MLLQMTRDAHASPSRNLGSRVTAWTARQKCRGQGTDLTPVIVFRKGPAICRTRPSPDPEHLFFIYHRRKRDNSNNRLNHQPPLSFTGQHPVSSSHSGKACLKQKRPVDESRWAQASSTAEIRHIRHPQYRTYGAGGTLQKQGFFSFLFFSLYPSSSSIHPSSPLVFPRLASHPLLLYVRALRVLSHDAQLRERGRKVSCVAPCIRSKLGYKEYCIKTYTPVHAQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2S1</accession>
    <name>A0A367L2S1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_4680</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2S1"/>
    <dbReference type="STRING" id="1330021.A0A367L2S1"/>
    <dbReference type="OrthoDB" id="9974421at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000095">
        <property type="entry name" value="Triglyceride lipase-cholesterol esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11005">
        <property type="entry name" value="LYSOSOMAL ACID LIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="9">
        <location>
            <begin position="135"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="476"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="477"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="515"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="562"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI08730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="576" mass="64853" checksum="0A1554882018BC2C" modified="2018-11-07" version="1">MPFPFLGRLHPTEYLAIVGSFLLVGLEAVIRVCTLSLPAFLVSLFYRASRLIFNRYTTPAQKRAENKQKSISTSVRDAADFVELCRIWGYEAEEHVVQTKDGYLLGIHRLQWKKGEEGQPVNCGHESLKKRVAYLHHGLLMNSEVWVCLTDEQRCLPFKLLERGFDVWLGNNRGNKYSKKSIHTSPASVIFWDFSMDEFAFHDIPDTIAYILDTTQQESLSYIGFSQGTAQAFATLAIHPRLNRRVNVFIALAPAMAPAGLSNGMVDALVKASPSVLYLMFGRRSILSSATMWETLVYPPLFCRLIDMGLSFLFGWRTKNLSTSQKLAAYPHLYSFTSTKSVVHWFQIIRNRCFQMYDDDLQKLVSVSSSQKYSKVAKYPTRNIRTPVVLIYGGSDSLVDIRSMLKELPPQTVATEIPHYEHLDFLWARDVDSQVFQHVFDALDSFTDAGHTREEYDRYYLVRSESLIGSAYSLTHNNRHNHHHHHHRGDSESEASTMAGSVDGGPSSPLLLQHHAREGQRDDSPRHSIAESTATTDKLKGVGRRRNNSTALDSIAEPKGSVGNGVKGKSGSGTET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L361</accession>
    <name>A0A367L361_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_4983</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI08866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L361"/>
    <dbReference type="STRING" id="1330021.A0A367L361"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF6">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="405"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="481"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="38"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI08866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="555" mass="61301" checksum="083748F8FCBFED77" modified="2018-11-07" version="1">MADVEKQPSQKVPVDLDTGSAHAENADDLHRMLNNRQIQLIAIGGSIGTALFVSIGNGLAAGGPASLLLAYTLYPILLACVNNSVAEMTVLMPVSGGFIRLAGHWVDDAFGFMAGWNFFFYEALLIPFEITALNLVLSFWEPKMKEPGPTAGICAAVILCYAALNILAVRGYGEAEFWLSGGKVILIFMLFSFTFVTMLGGNPQHDRFGFRYWNNPGAFAEHHTKGSLGRFEGFLGSLWNAAFAVVGPEYISMVAAEAQRPRVYIKAAFKTIYLRFGIFFLGSALAVGIIVPYNDPVLVAVSKGEKGGGTAAASPYVIAMQNMGINVLPHIVNALMFTSIFSAGNTYTYCATRSLYGLALEGRAPRFLRKCWSNGVPIYCFCIVMCFPLLSFLQVGNGSALVLDWLVSLITAGGIIDYMVMCITFLFYYRACQAQGVDRKSLPYYGWGQPWCATVALVFMTLVVLFYGYEAFTPWSVDGFFRHYTMQMVAPILFVGWKLIKGTRIVRPLETDLIWQRPTIDRYEESLTDEPVGFWTEMGRLVHINPEKKKRPLDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3D7</accession>
    <name>A0A367L3D7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_4765</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. LaeA methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3D7"/>
    <dbReference type="STRING" id="1330021.A0A367L3D7"/>
    <dbReference type="OrthoDB" id="184880at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI08722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="45548" checksum="BE365DA071A70A06" modified="2018-11-07" version="1">MQSQGETPSSVADKTADAHRNAPRQTMCSASSSSTGYEPQLASPLTHPNGASIFPSLSTSEQEAMSREALSQAQEAIVADNFDEQVVHDESDAGYSSDGFSSGSTSAESSVRDYLYENGRRYHRFREGTYNFPNDDVEQEREDMKHAMVRLLCSQKLHFAPIGQHPQQVLDMGTGTGIWAIEMGDQFPSAHVLGVDLSPIQPDWLPPNVRFLVDDVESTWLYPRNHFDYIHSRHTVMAVRDWRRLFRQAYEHLKPGGWIELQEIHHKPRSARPDGNMPENHAVARFWARVNEGLTALGIDLDRAAGGFLAQSMGDEGLVNVTERVFHVPIGTWPKNKVLKTVGLYWRTILLDGLQAIALGPLTRGLGWSRDEVELFLMDVRRAYHDNGALMYMPLHIVYAQKPEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3G5</accession>
    <name>A0A367L3G5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5089</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI08969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3G5"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI08969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="82" mass="8662" checksum="D5D4186F202FEF7E" modified="2018-11-07" version="1">MSGFSHLSSTVPAHHVFGGSDHPTPGSIARLPGVGEWSGVEWGVEKWDICLLISASLRNKGSLLSLSLLLHPLVDDGLVFGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3L9</accession>
    <name>A0A367L3L9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_4974</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI09025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3L9"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI09025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="146" mass="14496" checksum="4BE18E6E8A9CC294" modified="2018-11-07" version="1">MRIRVAVDGADGVNDMFGGQFVASGDPGLAGGATTDEAALMNEVGAGSAVDGAVDAASAHEGRVGGVDDGVEPELGDVAAGDADAGVDGSGRLAGGRCVGDEFGGCVELGEGWDVVDGSDSGGGHFCCCWELMEDDEKDLRLTWAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L493</accession>
    <name>A0A367L493_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tr-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_4914</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI09032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5342685at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF30">
        <property type="entry name" value="TR-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="279"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="321"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="759"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="451"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI09032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1325" mass="144982" checksum="D592A3E277A134CE" modified="2018-11-07" version="1" fragment="single">MWHRAFIRREDIQSVLTRIAYPNREGWELSILQSLALTDMSGFQDHGAITTSNGQGSALPLLRDTDEHDSIGDVVLGLCSGGYYQVSLRVVASHNRCQIETDARGHLFEQRSGQWLADSHLGTLLTFLQFLFVAITSYVAQFDSTRPPLYLTPAKVPFRHWVVNIVLFFSINVLNNHAFSYSISVPLHIILRSGGSITTMLADQVDSERPTSNVGLLILFVAQLLSAALGLHTETIYEQYGPQWRENLFYSHLLSLPLFLPFVPSMARVLGRMTTSERMAIPAPFLAADVAGIPIQLAYLATNVITQFACIRGVNLIAANASALTVTIVLSVRKLVSLIVSIWLFGNTLPKGTLMGAVIVFSSGALYSMDSRPKQVKTTDTKDDQALGPIKSMATSIINGQSSSAPDSINRYELNAVIHEGVALDITRLPLILLRLSDSLATLRNKSKMTVRIPKSSKKDHSSGRKHCPMASIFTYDPDPPRVSSPWLAADEDKDQGPGDFLAPKLASEYGLTRLQAEPQRGPTEYKLHLLLRPRRAYTFMSTTRQASLSSHVDLLEKFPLDNVSASSMVSGLLRRERLKHLTTQLLWRLQQSSPYHASSSKEVNLPKLPVYDVTLDAPIKVEPLVPGIRESRGALYELGVSDDGTLVGLTEDEMRESMATLRLMAASLGCVVDVVRLVIVGDCEWTEQTMTPPDDNFCHRQDTHQTARLWVVEAFVTPSLVFHCENDDVLSSATPWTPDMSTNSALPGHGSSTPQLRVTLTGPTTCGKSSLLGTLSTGTLDNGRGKSRLSLLKHRHEIASGVTSSIAQELIGYKDREIINFAKGNIDSWVDIHDCADAGRLVFVSDSGGHPRYRRSALRGLMSWAPHWSILCIAADTNDEVRPDEVGETPTTHELRDLVEAHLTLSLKLDVPMAIVITKLDLASKSSLHMTMTKVLTSIKGAGRVPRILQPDQRQFDGPGHITREDQSKVETVCAGMTKSENLTGEVPILLTSVVNGTGIGLVHALLAALPLPPMPAPWDRISPMETRQPNCLFHINDTFRFPESHTTLAWASKGQTGRSVIVSGHVRYGNLSVGDKVVIGPFRPMAEEACSLELAMREHTSSRRNLLIPQKPAAILPLSSGDPTSAAVEAEEWRKAKVVSIRNLRLPVFVLGAGQAGSVGLVFDPDTRNPELIDDLPRLRRGMVLAALSKQMSDDGLSPRTASRFTAIFCDVGIRSLVERAIVDVYFASAKAVARVIGLSHHEQATPSANPCGAVPTLEARDSDVSHATAHAPHEVNRAEVTLELLHNREWIGLGCTVLLLAAGRQEMFGLQGFVGKCIEVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4Q8</accession>
    <name>A0A367L4Q8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="5">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_3674</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="LKCN02000015">
        <property type="protein sequence ID" value="RCI09414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4Q8"/>
    <dbReference type="STRING" id="1330021.A0A367L4Q8"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004104">
        <property type="term" value="F:cholinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000997">
        <property type="entry name" value="Cholinesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00878">
        <property type="entry name" value="CHOLNESTRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016483078" description="Carboxylic ester hydrolase" evidence="5">
        <location>
            <begin position="23"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="6">
        <location>
            <begin position="25"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="4">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="4">
        <location>
            <position position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR600997-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI09414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="529" mass="56973" checksum="E40987CA3B2B2266" modified="2018-11-07" version="1">MTPPTTALSIVLSLQLLAGAQGSLPTVTIDTGDLVGTTSAFSSSSAVVNRFLGIPFADAPVRFNRAEPVSSKWQDVYNATQYKPACIQNFKGPEEHRRRTMKWFDSPPPPNGESEDCLYLNVYAPADAAPGSKAVMFWIYGGNFQFGAGSLPLYDGSSFVANQDVVVVTSNYRTNVFGFPGSSEKPQSEQNLGLLDQRLALDWVQRNIHAFGGDPKRVTLFGESAGAGSVDTLILNPPPQPVPFAGAILQSGQSAISLPNHDSAASWTKLTKATNCDGLACVRALPAEQIRHVMQREKLTFFPVYDDGTTYASTGRIDRRNASSSRIARVPLLIGSNADEATVFFYGLNNAMSGLRLQVPAEEGLSKLLGAYSPKQALNRRLVSLAGDFTFTCPAKVIGEESASVGIPSWRYVFDAAFPNHEAFPGSGAWHSSEIDLVFGTYSRAGATAYQEKLSRAMQKAWADFAKDPSRGPGWASLPDNVAVFGGGVRPGKDCEPSTPAVDVSNGAKYDGKCWLFKPIYDAATLRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-05-03" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L568</accession>
    <name>A0A367L568_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_4126</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L568"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI09583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="149" mass="16719" checksum="DF09CDB7B4AA4436" modified="2018-11-07" version="1">MSVFGIKPRRAEGGVRIWSNGTTTQAGITMIVRRADDDDSVFRENDWKPRRVAIDTISYSVCFVRLLSVSAEGIDVAEPQRFLPESEGHVEREVCGGVRCVCSKVGICVEELRALSLWLASAKKDYSERPSFLTMKCSMQVARRRFATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L599</accession>
    <name>A0A367L599_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_4120</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 11">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7"/>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L599"/>
    <dbReference type="STRING" id="1330021.A0A367L599"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000003">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="8">
        <location>
            <begin position="221"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI09578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="416" mass="47155" checksum="125C617237EA238F" modified="2018-11-07" version="1" fragment="single">SIYLPPRFLSARASSSVLPPLPFLHLFCAPAPGGPVLFSPVCLIAEVWGQSDRPRFSSSSPFPPAPLYHRHLLRQVPRFVTRRKKVIHIMDTNMEDVGRAPAEVSPVQSEPASIPTLDGWIESLMNCKQLAETDVQRLCDKAREVLQEESNVQPVKCPVTVCGDIHGQFHDLMELFKIGGPNPDTNYLFMGDYVDRGYYSVETVTLLVALKIRYPQRITILRGNHESRQITQVYGFYDECLRKYGNANVWKHFTDLFDYLPLTALIDNQIFCLHGGLSPSIDTLDNIRALDRIQEVPHEGPMCDLLWSDPDDRCGWGISPRGAGYTFGQDISEAFNHNNGLTLIARAHQLVMEGYNWSQDRNVVTIFSAPNYCYRCGNQAAIMEIDEHLKYTFLQFDPCPRAGEPMVSRRTPDYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5L2</accession>
    <name>A0A367L5L2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5L2"/>
    <dbReference type="OrthoDB" id="4912541at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017051623" evidence="1">
        <location>
            <begin position="40"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="336" mass="37003" checksum="E3636CBC8A30BE29" modified="2018-11-07" version="1">MTTPMTMILPTRLTATATTISAAPLLLLLLLLAAPTATAYLGCHASFETNNVQYYRSSNGCCGPEFATVLRDSRGAISSVQCGHVQVKGNTEWLKEMAPCDKLSVWGPSCSHIRYPLEGVPQLDDCTADITAPKPDDDAAGIIIAPDDPAGGRGCYSGRIYVHAGKCCSVDYVVSDHDGVRCGKKAIYLGPDNQLPPHLVDVPKCNKMIDHADCPHGVFASFNALIRAQKCRTCCPPGQTRDHNYNCRVHDMHVWNLAKYWKARRRDNCELPKPGPNCCPDRRHSRNSRGECSHRNGREVPTASELYVRRIERDGCTDFLDHLGSEDSGFDLDMER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5M4</accession>
    <name>A0A367L5M4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5M4"/>
    <dbReference type="STRING" id="1330021.A0A367L5M4"/>
    <dbReference type="OrthoDB" id="10003767at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF37">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="55"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="389" mass="43971" checksum="D0EFAED4B4C05062" modified="2018-11-07" version="1">MPLDTTWRKMCSYPLDTYIGRSVNECLARTNWHQLCLLASSLRQGVPCRVLPELKNGLHHLVRLLAFDDGTTWIARVQMHTSTQNSALLLQSEVDTMTLIRQRTSIPVPTVYAYEVDTRNPTSAAFILMQVVSGNVATDSDGGYQVHQGQIPLYRRPSFYLAVAKIQVQMTSVRLPLIGMVTQDSITGNYIVGPFPHLGGPFHTATDFIKAWARHSCFPLSDDAVDRIPSAALRSRILTSIQAFPNELASSAADLITHNDGPFPITHTDFFHSNIIVDSKYHIQAVIDWEGACTMPWELVEPPLFLETVPPELDAPNNYDENGVPVDQDTRQRWDDRRQYEKLVAEMELETQGDNMLSLTLSNRRHQKLAYAMRVYTNPGKLLFYDRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L689</accession>
    <name>A0A367L689_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Tricalbin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L249_8397</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI09918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367L689"/>
    <dbReference type="OrthoDB" id="1029639at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04044">
        <property type="entry name" value="C2A_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04052">
        <property type="entry name" value="C2B_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04045">
        <property type="entry name" value="C2C_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04040">
        <property type="entry name" value="C2D_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21678">
        <property type="entry name" value="SMP_TCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037761">
        <property type="entry name" value="C2A_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037765">
        <property type="entry name" value="C2B_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037762">
        <property type="entry name" value="C2C_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037756">
        <property type="entry name" value="C2D_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031468">
        <property type="entry name" value="SMP_LBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056910">
        <property type="entry name" value="TCB1-3_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017147">
        <property type="entry name" value="Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052455">
        <property type="entry name" value="Tricalbin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46980">
        <property type="entry name" value="TRICALBIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46980:SF2">
        <property type="entry name" value="TRICALBIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24920">
        <property type="entry name" value="C2_TCB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25669">
        <property type="entry name" value="SMP_MUG190-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037232">
        <property type="entry name" value="Tricalbin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51847">
        <property type="entry name" value="SMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="9" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-LTD" evidence="14">
        <location>
            <begin position="233"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="434"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="577"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="703"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="13">
        <location>
            <begin position="1047"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="58"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="124"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="859"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1236"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1422"/>
            <end position="1459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="860"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="873"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="907"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1282"/>
            <end position="1303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCI09918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1459" mass="160414" checksum="313BA7A8F0EF8A7B" modified="2018-11-07" version="1">MSALDVSEIKAQGAIEAAEDPQSLVTADQAEKEIVELSRNAGVAAFNFDPDASLAEKRAQARAAIPQELQQSRRAKGAAIITDQDDGTGPDEDLPEPSKSGVLDVATGADGKQLTDGADPLAAEEPYSRTGWAPQTGWPASEAEEGESLLDHTTWVEGKLPDSLYGDWYHNTALIVFACLSSWLIAVLGGGLAWVAIIMAVCATYYRTSLRRVRRNFRDDITRELSMKKLETDNESLEWINSFLVKFWPIYQPILAQTIINSVDQVLSSATPAFLDSLKLKTFTLGSKPPRMEHVKTYPKTEDDIVMMDWKFSFTPNDTADMTAKQVKNKINPKVVLEIRIGKAMISKGFDVIVEDMAFSGIMRLKIKLQIPFPHVDRVEMCFLERPTIDYVCKPLGGDNLGFDINFIPGLETFILEQIHGNLSPMMYAPNVFPIEVAKMLAGTPVDQAVGVIALTLHGAQGLKNTDNFGGTIDPYACISFSRRQELARTKTIDDNPNPRWNETHYLIVTSFNDTLDIQVFDKNDFRKSKELGVASFQLEDLLDDHEYENERLEVISNGKARGIVSCDVRFFPVLEPEKLPDGKIEPPPPSNQGILRFTVEQAKDLDGTKSLYGLLNPYAAMFLNGKAIHQTKKLKRTNNPIWDNGSKEILITDRKKAKLGVTIKDDRDLAADQELGKYQIRLDEILECMAQGKEWYQLSGAQTGPSPSPASPAPGGYLTPIGVMRLHFMKATDLRNLEAFGKSDPYVRVMLSGIDKARTVTFKNDLNPEWDEVLYIPIHSERDRLSLEVMDYEKVGKDRSLGAIELFACDYVQEAENGELLVHDKKEIREDGLRLHGKGVTKGTLTYTAAFYPCLNVADPDDEEEEGADGDAADKEGRETGSDDKSVVGSKATPTSENGEGLPRRSLSTKGRSSQSDGPPKIRLSPEELLKHESGLLIFRLLEAELPDNHSRLEVWVDDMAYPSYVSSVAPSRGHKFDEIGDCVIRELDVSRLTLKARKKGDDKDEMVAQLAGNTMETLKQCLNNPTMLKLKTEDGKDGWVKVSFKYIPVKMQLDPSESINNMGKLRVDILDGTDLPSADRNGKSDPYCRFELNGNDVYKTKIIKKTLSPVWNECFEVNVPSRTAADFFVNVYDYDFADKPDFLGGAVINLASLEPFKPLEAHYPLDGKSGSVRIRMLFRPDYVTRTMHGSSTFSGTMGPGRIVTGVAGAPIKGGVAVAGAVGHGVGRGASRLKRGIFGKKDGGDDANGSMAEGPDGVGDVGGMLPRRSTNQQQAEDHQPASRNNSFSHGRTKSITASSMHSLSPGAGNGSAGKATLTIVKASGYPSSTDLYVVVSQMAPKEKVVGKTKHFKSSSSEWAFDETFNVRCNSDAQFKIEVKVDRFLGSDEELGEHVYFVDETGAATPKDLHVGGGIVTIKSSFQPSEAQAESPRSHNLRRSFLGKRGEGRSSREATPNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6G2</accession>
    <name>A0A367L6G2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4179</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6G2"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="88" mass="9184" checksum="9104D3A105C18E50" modified="2018-11-07" version="1">MTSKEGERAEDEADEGQDDGQQDEKSAGGGHDVLFGVGAYAMRSSFILARGESVSLLGGPRGREKGAVIRPHVGGRPGTRLDLTLTDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6W0</accession>
    <name>A0A367L6W0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Threonine/serine exporter-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_8624</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ThrE exporter (TC 2.A.79) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6W0"/>
    <dbReference type="OrthoDB" id="413008at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051361">
        <property type="entry name" value="ThrE/Ser_Exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082:SF4">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="533"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="558"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="581"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="609"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="648"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="690"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="716"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="821"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="882"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/serine exporter-like N-terminal" evidence="4">
        <location>
            <begin position="428"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="170"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="233"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="289"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="796"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="126"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI10170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="917" mass="100881" checksum="FFE683FEA812AE27" modified="2018-11-07" version="1">MAGEPTSSSSQPSDVPTPSRKPKKRVGWHSSSNSGGGGVGSGEGGVGSGGNDGSASRSPLASPGRPLLSNPPGAPDAHELVLALTKVLSDEREQQREWQQAPRPALRRNTSYDAPEEREKADQAEQRATQRQLRSLTDARQRADRLAISVVRDSAPGSRRTSHDLEAAFQPLMDDPDDVDESDAATSPDSRLDDTLLTPHCRRRNIASEDHVCAESLVQSHTLRDRARGLFHRKHSSPAGHQAQQQHHHHHHQQQQQQQQQHHHQDYVSRPPRYRGGILSSLLRLYNDDRGAGGGSNNSSGFTTPTSPATPLMSPRPSPPPSRPASTAGGPRVRSGGGLFGHSTTSLSELIKSSSMLAAPVTSEVHDQWADKIRRERPQRSSRKERARITVHIAGIISRHRYLLKLCRALMMYGAPTHRLEEYLTMSARLCRALMMYGAPTHRLEEYLTMSARVLEIEGQFLYIPSCMLVSFDDSTTHTTEVKVVRVPQGIDLGKLRDVHNIYKDVVHDKLGVEEATRRLDEVMQRKPKFHTWMRVPVYGIASACVAPFAFEGRFIDLPIAFILGCIVGLLQLVFAPSNELYAHVFEVSAAVITSFLARGFGSIQQGKLFCFSALAQSSIALILPGYMVLCSSLELQSHNIVAGSVRMVHAMIYTLFLGYGITIGASLYGMMDKNATSDTHCRDPLTRPWYFIFVAGFTLSLCVLNQAKWRQTPTMTFMALAGFCVNTYCSIYFEQNTQISNMLGALTIGILANLYSRLGRHIHNYWLNLVEWWECRMRPRFSRRRRPAACADNWSIPSMSDPESRPSSPEKPVHRQQRKVGYSLAAAAMLPAIFVQVPSGLAAGGSLLAGVTSANALNGNPEVLANGGSRMGGIDSTAFNVLFSVIQVAIGISVGLFMSALIVYPLGKRRSGLFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7E8</accession>
    <name>A0A367L7E8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Heme haloperoxidase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_4363</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7E8"/>
    <dbReference type="STRING" id="1330021.A0A367L7E8"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF19">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016605044" description="Heme haloperoxidase family profile domain-containing protein" evidence="9">
        <location>
            <begin position="21"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="10">
        <location>
            <begin position="76"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="54"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI10339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="369" mass="40355" checksum="1CC977A28D01CEE0" modified="2018-11-07" version="1">MRAWHLISFYLVTSLDPVAGFPQFVNGQFRLPFLPGQLSQPPFGPANSPILTPRNPGDPSTWRCPPGTPGARRDANGHYFQPPGPNDSRGPCPGLNALANHGYFRRSGKQVNLLNIVFDALRGIGVSPEIGLIVGALGYISKLADLKRVLSLGFDLDELAGHLPTFAIEHDCSFSREDYALGNNNDFNPDLWAVALKELGNSKNVNAFSLGRAKGARVMDEKRRRGFNSYEPRSIAFGAVEVGLILTTLSPLSLGLVVGNSPLEWVRSLFEQERLPCEWAPFPLKTNTITVLALGVESLLGNKRLLGDVLEGIILSPKGILDALFRHRNGTRPSSEVRQHQLSLMRYAFSEAGHNASGVDELERLWGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7G1</accession>
    <name>A0A367L7G1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosome biogenesis protein Urb1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_4299</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7G1"/>
    <dbReference type="STRING" id="1330021.A0A367L7G1"/>
    <dbReference type="OrthoDB" id="72892at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059018">
        <property type="entry name" value="HEAT_URB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039844">
        <property type="entry name" value="URB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032436">
        <property type="entry name" value="URB1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021714">
        <property type="entry name" value="URB1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500:SF0">
        <property type="entry name" value="NUCLEOLAR PRE-RIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500">
        <property type="entry name" value="NUCLEOLAR PRERIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26140">
        <property type="entry name" value="HEAT_URB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16201">
        <property type="entry name" value="NopRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11707">
        <property type="entry name" value="Npa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="URB1 N-terminal" evidence="2">
        <location>
            <begin position="99"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="URB1 central HEAT repeat" evidence="4">
        <location>
            <begin position="631"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="domain" description="URB1 C-terminal" evidence="3">
        <location>
            <begin position="893"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="810"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF26140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI10363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1133" mass="125305" checksum="E990ACC8611628AA" modified="2018-11-07" version="1">MGKRPSAGPQGPSAPRKRQRTAAAVDPPAGEHVTSSVQLRNLLVFDQDLRKARHGLQSFKKLLDDIISDQGNREDNLAILQQYLDATKPKDDSQDAVHLQDIMDMWSFAAQVNDDGVMSSVAVVLALLLRVASDSLKLVSHGLGVCQTILQERHLKCLSKNLASENRKAFIISPTLRLLRAAACLDGGAYAKSIVRASDYTFTSLSRNLELGHAGPGPEDPGKSSIRTNAVRFFLTCVKHLNSQGRKELLSQRHLFSRLTYSIKSDPPDVALEILDVLRCCVLMDSKIPREAKFRNFNTRTLLRILALYSLPGGDADKENPVSERAHEFLMCVCTTPAAGVLYPYKGLYPKELEDEQSDHAASRQAETRLDDKQTGQFDTDVPVYNFALAEFANKLRPWACTKQSQLLVAMFTAAPELIAKYLHDNRFFTFEPKDSMTWVGYAAFLFDIISIPLPPSFGNPSRYAEGPPPTSVLLDNILPPAVTHKVLVRCFSLKSDVTSLFATKILVAALEKLAVALRMHTFTQGRAKVKWMEAARRLEDTFCQRVPDMKEIVQCYRAIPADNSMHKTLASRLLLLYYRVIPRVALTANFDVSPLLSAVLEGLRKTELASDARQLSLIELESLVTIASYSPGMRWFSRTDSSSHGSSTSAFVALLQLLCGGQGDALVCHIKEALANVAVESQLVSRAAGLNPLLAALQLTTDQVNAEEMDVVWSFLDNCISRCVASPIKYIDAMETLMSDASLQEDNSSSLLNLALVEQLPYAANSGEKRALKPHARFLSLYFNACYLREGDDGLLRALHQQLNRHLSSGKAKMTDLGDESDTAALKAQDSADERDEGSSRAAGGQKAVSGEVNLQHALQVPPLEEADPTALTKCMSKSVEDVIEDGWATKLIRLLLSEHTHIRKEALTGILKVTARMKESSSYQDGPQIWLLLSELAESSRPLLESGPVPSALVAFAAHAMDVLQSPLHPLYAKVNRYLTRSPVWSPDKIPLAHDILHGEPSEDDRYYAEIAWLLTYLVECLRTSRDLDVFRAKKWFEKMLALASNPHLRAGLRNRLLAIVYRATCIHGGSTTLVTRFGVLAWLDGQRVGSDTAVEAGVCRRLMRRVWETCDQQRVAVWSHDGARKLVQSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8D1</accession>
    <name>A0A367L8D1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8D1"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016852137" evidence="1">
        <location>
            <begin position="20"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="79" mass="8223" checksum="147546B595E1AC55" modified="2018-11-07" version="1" fragment="single">MAVVMAIVTAALGSYPYSAVDLVPDPDPDPDPDPNPDPVPVVAFWRRENDTLASVTYGGLGPAAADPASQCLALPLKYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8M9</accession>
    <name>A0A367L8M9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">triacylglycerol lipase</fullName>
            <ecNumber evidence="6">3.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Autophagy-related protein 15</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">L249_5346</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by ATG15 is critical to life span extension.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12044"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17855"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="EC" id="3.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to both phosphatidylinositol (PI) and phosphatidylinositol 3,5-bisphosphate (PIP2).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endosome</location>
            <location evidence="3">Multivesicular body membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Prevacuolar compartment membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AB hydrolase superfamily. Lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.3" evidence="6"/>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8M9"/>
    <dbReference type="STRING" id="1330021.A0A367L8M9"/>
    <dbReference type="OrthoDB" id="58570at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032585">
        <property type="term" value="C:multivesicular body membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005775">
        <property type="term" value="C:vacuolar lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034496">
        <property type="term" value="P:multivesicular body membrane disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046461">
        <property type="term" value="P:neutral lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006660">
        <property type="term" value="P:phosphatidylserine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000129">
        <property type="entry name" value="Autophagy related lipase Atg15, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050805">
        <property type="entry name" value="ATG15_Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47175:SF2">
        <property type="entry name" value="LIPASE ATG15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0072">Autophagy</keyword>
    <keyword evidence="8" id="KW-0967">Endosome</keyword>
    <keyword evidence="16" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="20" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016570714" description="triacylglycerol lipase" evidence="20">
        <location>
            <begin position="26"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="21">
        <location>
            <begin position="284"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="494"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="569"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="615"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="495"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="572"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="632"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="RCI10774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="641" mass="69036" checksum="CFE8E8D90D476802" modified="2018-11-07" version="1">MSSAGRVIATTLLSLLASAPHLASADDTLFLPLNEHIFLPPGPPSGFSPHPEPPAPAEHSFTLRHIYHHGVARYPELHRKRDVNRQDDDDLSRIFLAAADGFPEHDLHRLTAKSSARTIERMTDRRPSVVDPIVAQSRRNGFAAVLDASAWVVDQVSSPDVTDKNTVLSLAYMAADAYVEDDDEARWDDVGVPFNRSADFGWHSDGLRGHVWADDSNSTVVIGLKGTTPAVFDGDGTTTKDKINDNLFFSCCCAQQGQWTWHQVCDCATGTYTCNNTCVVEALREENKYYAAARELYSNVTELYPAATIWLTGHSLGGAVTSFLGLTYGLPVVTFEAVPEALAASRLGLPVPPGADPNMPQTRENTGASHFGHTADPVFVGSCNGATASCSFAGYAMETACHTGRECVWDVVADKGWRVGIGTHKIRSVIQDVILEYDEVPECKFVPECRDCGQWKMYESNGTRTATSTVPSTTMTRTRTSTCETPGWFGCLDESTTGTQTSTETSTSSSSSTSTCKTPGWFWCKDKTTSTSDVTTTTTATTTTTTTQPVTSTSTSTCETPGWFGCKDETTGTETGTSGTPASTTMTETKTTTCKTPGKVWGCWDETSRPAAAVPGTMASLRPPPVTATATAEKDFLPDEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L995</accession>
    <name>A0A367L995_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI11001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L995"/>
    <dbReference type="OrthoDB" id="4842715at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI11001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="115" mass="12802" checksum="4F47ACA495267611" modified="2018-11-07" version="1" fragment="single">YIACGYFPARYKESNVIVLRKAGKSLEVLRTPGGYRPISLLNTVGKVLETVLGSVSLLMLDITSAFNYLTALIRSYLTSRSSRLKVDSCLSEPFNIERGDETAKHLFLRCPRISA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9F5</accession>
    <name>A0A367L9F5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5213</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI11055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9F5"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="67" mass="7333" checksum="D939E8106D563BD7" modified="2018-11-07" version="1">MTPRILSSSFPPITPDKSSSLSPPSKSCLFHMLFHHRLKHMLVIDNLSFVSATSPAKGSEHLSTSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9L5</accession>
    <name>A0A367L9L5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Retroviral polymerase SH3-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9L5"/>
    <dbReference type="OrthoDB" id="4960422at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057670">
        <property type="entry name" value="SH3_retrovirus"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25597">
        <property type="entry name" value="SH3_retrovirus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Retroviral polymerase SH3-like" evidence="1">
        <location>
            <begin position="19"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="108" mass="12503" checksum="04D92B97F3DDE2AA" modified="2018-11-07" version="1">MPYILLPSIAELNALAGYQAYVSIPLAYRIQSAKIAPRAKEGYLVSIEGLYRHIYKVFLLDKDKIVRARNIRFYNPANLNLDKSITHIANVSKNNNPFDPNDFFYYYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9Y8</accession>
    <name>A0A367L9Y8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7763</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9Y8"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI11224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="147" mass="16324" checksum="CB00E169838A1C1C" modified="2018-11-07" version="1">MPGRLQPARGRRGGYAIQRLRPYGPYGPYEGRNVGGGEDEGPALADLAAFFFLPIAGELTANSTLFFFDLCRYGYGYSYSKRPYCYSSPTASSFPLERFLRPDFFGCFFSSSSLLSFSSLPLLPIAGPTTYSDDRNRVRIRAPGRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LA81</accession>
    <name>A0A367LA81_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cysteine-rich transmembrane CYSTM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LA81"/>
    <dbReference type="STRING" id="1330021.A0A367LA81"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="131" mass="13779" checksum="ABF94D99FF6D3075" modified="2018-11-07" version="1">MSNQEYYGGGGGGYPQHPQPSYGPPQGNYGPPQGYNGGYQQGQPPMQYQPAPPPNDSRGRRGGSNNCLMACLAALCCCCVAEEVSRAANASVNTNSAPHSPSDVEWCCGLQRPLTSSAKPHHLTTSSTMYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAB1</accession>
    <name>A0A367LAB1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pentatricopeptide repeat domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_7134</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAB1"/>
    <dbReference type="STRING" id="1330021.A0A367LAB1"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016802907" description="Pentatricopeptide repeat domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="693"/>
            <end position="713"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI11360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="726" mass="83612" checksum="D10F3D420BC69E42" modified="2018-11-07" version="1">MLSLWLGFTLLRPCGCRACNSALRGGSRRVTTAARRRKPSLAEILTACYSTVILSATCADAFRKDRRRIEIDQKLDAARKALVDLQNSDATRKLDARPYDTPTPDMTRRQMIAVWGALKNIYNDRSFMEDAYISRPVGGWDLVKHLKIRLYNCPDRRELSNRRKTDYDGLERAAVAEQQDPTIRLREARDETHLFYEVAAVERLVCRFVCRAKRQEIASRSTPWLRDAIERMLNKGGVEYAFPEVDRARWRRNVEILTQHLRQCIASSGESLRQKIGKVCYNLLVSAYAPDIFVYNTLIVAFSRAYLNTFADIVIWSFFHERCMRPTALTYVLVLNHYSVRSDYGNFLKVIGRIAGCDGEVGGKIARRHIEECERGGKLGKWARDDGIRTQIGEWVFQHVPLTRNLMNEIVRGLVRFKLFQQAVYLYFACMACKFFFSPAMVRNLLDECVNALDRRAAVELIRGLINHSREWKAAMMTGDVETDWYLINRIYTLLEICGLRCGPEQVSEQYLDALGISPASLAGLLADLDLHQHWLRKPCFPLSVEGEPSVVRSQSRLLQIQSLRREVDVVRGTTRSLESTLLYPCFPLEFRLLMVQFIGEQALEYSSRLMDETGELLNSIVGFGPWLVPLLWDRRMCARELFVKRQRLEQDYLARVMSTESEAELEDLMRERHNSREAEVLVAELRMSATIAQSRRQPEAPPGIRATESDPTRDRILKLLLTEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAK3</accession>
    <name>A0A367LAK3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAK3"/>
    <dbReference type="STRING" id="1330021.A0A367LAK3"/>
    <dbReference type="OrthoDB" id="27237at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010770">
        <property type="entry name" value="Ecd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060:SF0">
        <property type="entry name" value="PROTEIN ECDYSONELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060">
        <property type="entry name" value="SGT1 PROTEIN HSGT1 SUPPRESSOR OF GCR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07093">
        <property type="entry name" value="SGT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="442"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="555"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="606"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="632" mass="71128" checksum="7420352EA3892744" modified="2018-11-07" version="1">MNSQPVRLQAIVMPETNRSEEGEGDEETLLSLPKTIPENSVEYWLFLLNHDEKENDADLEALHQAADDLSQSLTEDYIWQRDHFQLELKEEDGTRCLYGITDYGDAIEDEWLIVYILRRMTEAQANLWVRVADTDGEFLLIEAANVVPDWLSPGMDQNRAWIHDGKLLIIPCESNGSNGSRPQTISLPKAVEFIRLRSAEILHSPFIQEEAFFRLGKYPTHISDSAHCSLVTIPRKLAYILHVLPKSLAPAVEYFYLRDPLSLQPIMSTSASLAFPTNDLVTLSVRFSRVLFAQLKSQHFDPPPMWQRVLRNAVLTAAPDDRERIARLETGMKLTTGFEILIATAGEDRRKVVQQVEALMKELPEGDNEMLPTDEEMKSWRDFNRNDGEAWMDINYEDFERELDGKPRRHTGGDRAGFGDAGTETDLRKIVSRFEAFLNDERAGLDGADMDNSKDDDDEETEDEDSEFEDKVVGFDEEAFSSIMRNMLGLPTANSSSADAEGPNSTLTRRGEKDAATQEDGEIQELSIQMENELRNHGALKYDDANAKQLAVDNGSRSVGKGKELERRCSTTGTVEDEEGDDSEVQIDYILARNLLESFKSQAGLAGPTGNVLGMMGFRLPRDDDDEGGEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAT9</accession>
    <name>A0A367LAT9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7666</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAT9"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI11362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="302" mass="33858" checksum="DEDABA45CF152023" modified="2018-11-07" version="1">MNPPYFCLGCGSVNVNAMAWCRSYDARTSIARISQASFVSEEILVIYPWFVSSSIYTNKLLRTYVRVSGVKTAQAVDYPHLPQGSIGYDIDIPSLSCDYFACPKRKSLCNACTYMTALIWKQTFSLRIQGNPQFCRRRFEYTHCLFASSQSQRGMRQADFMPRSGDDRRKFLLETITRLPSVVSMMGWLLEISSLSLYKMNESFLICKTRLFHPSVPPYTHPILLPEKSTTDMKVIFFFASAALAMAAPNAEPYNNNNVLQARGGKICIGQGDTCPKGSLQCCPGLRCIGGGSNKKCQKIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LB73</accession>
    <name>A0A367LB73_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7357</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LB73"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI11677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="224" mass="25055" checksum="F6BFCDC75AC6BF3D" modified="2018-11-07" version="1">MHQQGSPLALRRRDVKGEDVNATDVCDTLCHPQLSYFLLSQIDGNINPNSSDEPLSDIHVSLRPNSLPRITAIPCRSSTAVSLPTDRFGWPLSRSSSSHRAVNRRWLQPFRPNGLPVPTNCSVIGRKRSVGPTLQMWLPCPKKKDDGRLCSARTATFPPPFDCRQARVRIARRTFRLQLCHGLEKLGDVIIILYRRTHANLIDFLSQVSINFPAPAPAMFPTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCP5</accession>
    <name>A0A367LCP5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_0159</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCP5"/>
    <dbReference type="STRING" id="1330021.A0A367LCP5"/>
    <dbReference type="OrthoDB" id="5818554at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052780">
        <property type="entry name" value="AAA_Catabolism_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="599"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="308"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="439"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="976"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="321"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="343"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="403"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI12208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1085" mass="118337" checksum="5769135A68D540E9" modified="2018-11-07" version="1">MEAVVGKLYMFVLFSSITPTVKASLVLSFEFLRLYINAFAFQATLNRAVARASQRASMKAQMVSNLFSDVAGNPDARFIYESIDAANSLLSILNSFIDPVAGLKCMPLKYCLYVIYAAVFLFKARLAGAISGEGDGGVRRAIQGTITQLQKTSTNPHSLGRRYATSLRLLWRKSSPAKHKNKTNARPETTVRPPLTPAQGALTRIEDMPRGDKAPLELDPLNGFSWRDLDSLGQYIASNSTMAAMGDGMLTSAEFDWEHSSAGLDDLAMRPQNEAVDSDGVSGGPPCRRCVEHQLQCVLAKSRRGGRRIKGVKGALPPNPARSVPVPVPPSSSSSHPVPPPGDEGEDDDEDDEDDEDDDEDDNADDIGRHDAYRHHASSAHGCWPSPQSAHTWRAESPAGSVAHDESSRRDSDGLEGHIASTDLLNPSDALDLLAQVADLDPGGRHGGSSGRDGAARRSSQVTGDGAAASPPAYFAPIADGVLTWLEASFLVKRYHDEYHPFFPVAYSSIFDGRPVSEWAEKEPHLLTAILTVASKDDPSWSRVHEACSQFMESLVTKLIHSGSTNIGSVEALLILAEWAPQRSNEYSTIGCGQEDNGAWMLVGMAIRLGYLQRLEQTALVPENGSQSVDVSRKRIAWAACYMSDRQVSIRLGKGFWSRGPIPSISWRAADFPSLQNQALGPDNLALLFQAQLELIQLFITPTVKASLVLSFEFLRLYINAFAFQATLNRAVARASQRASMKAQMVSNLFSDVAGNPDARFIYESIDAANSLLSILNSFIDPVAGLKCMPLKYCLYVIYAADDFASVLRKWKLSWANFTPTVKASLVLSFEFLRLYINAFAFQATLNRAVARASQRASMKAQMVSNLFSDVAGNPDARFIYESIDAANSLLSILNSFIDPVAGLKCMPLKYCLYVIYAAVFLFKARLAGAISGEGDGGVRRAIQGTITQLQKTSTNPHSLGRRYATSLRLLWRKSSPAKHKNKTSARPETTVRPPLTPAQGALTRIEDMPRGDKAPLELDPLNGFSWRDLDSLGQYIASNSTMAAMGDGMLTSAEFDWEHSSAGLDDLAMRPQNEAVWSGHDIIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LD66</accession>
    <name>A0A367LD66_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_0040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LD66"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI12378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="44" mass="5115" checksum="ED167C112CB8ADFF" modified="2018-11-07" version="1" fragment="single">RTKQSEAKRSKARWLISKPVVPLRTKLLDADQIETEHERNSNAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LD77</accession>
    <name>A0A367LD77_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="17">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">L249_1290</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 22">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="17"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LD77"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02584">
        <property type="entry name" value="RNAP_II_Rpb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02733">
        <property type="entry name" value="RNAP_II_RPB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.30:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.390:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.140:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.180:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000684">
        <property type="entry name" value="RNA_pol_II_repeat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007075">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007073">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038593">
        <property type="entry name" value="RNA_pol_Rpb1_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006336">
        <property type="entry name" value="PRK08566.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF37">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04992">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04990">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00115">
        <property type="entry name" value="RNA_POL_II_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 17" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="13 17" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 16" id="KW-0853">WD repeat</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="148"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="16">
        <location>
            <begin position="180"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="19">
        <location>
            <begin position="1052"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="549"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="615"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="681"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="2292"/>
            <end position="2581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="574"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="687"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="18">
        <location>
            <begin position="700"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="2323"/>
            <end position="2347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="18">
        <location>
            <begin position="2349"/>
            <end position="2375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="2406"/>
            <end position="2420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="2431"/>
            <end position="2473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="2486"/>
            <end position="2504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="2519"/>
            <end position="2530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="2534"/>
            <end position="2548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="2549"/>
            <end position="2573"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="20">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RCI12388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="2581" mass="282986" checksum="AEBE35B21C5078EF" modified="2018-11-07" version="1" fragment="single">VGDDGFGGSVHEVKGPSIVGLGELVFGAHPSSAIGSDGKDDKTEFGFSLSESPSVEADDDPCLRHELLGFWAADLEFAMDAGMNCAKSPCVKMALRQPHSLQSSYLLVCVAPQNPSRIMNLLLSDDYLLQDYPESITNIIRSGHATMLRFNRKGDYLASGRGDGTVVVWDLETMGVSRKLRGHNKSITFLSWSRCGRYLLSTCQGWKAILWDLQNGKCLRQIRFRAPVYMAELNPWNHLQFVASLFEQQPVMVDMTEPDQVMHVLPSAPKRSNAEGDAAVKEKQAKEDAKQMTTSAIWTAAGDHIIAGTNKGRINIIDARTMDVIFSEKVCGGVITTMRISGSGRELLVNSQDRIIRTFRIPNLSVDDLDLDTVQLPLEHKFQDVVNKLSWNHVTFSATGEYVAASTYNNHELYVWERNHGSLVCMLKDPKEEQGVIEWHPTRALLAACGLETGRIYIWSVVSPQKWSALAPDFAEVEENVEYMEREDEFDIYAQEELRRRRLDAEDEHVDVLTLDPSKTDDNDVDEFRMPILFNLGDSDSEDEFVAVSTGTMRRRSPGEGEEARPEEEEGEAAEAAAEAVVEGGAGSDDVGAEGGSEGREDTLFTAWGLIRRRGHGSTRQNGGGGATCPANAVPPVDPATTAKEPGARYPLPEGTAGLTSAACNQALCLCLNSRFFSGRPSSGGSNLPSSQKSLPSNAHNHHQRAPPHRALRSENRSKALRLSTSRFFFYSCSPSIRPTTADEPGEGDLPFPALPWARLASEGGRAIAIVGRQRRAPFIARSYPFERLSLIESERAGGIFPPTRTFPLYRPVTHAYPAPLKTVEEIQFGLMSPEEIKNMSVAHILYPETMEENKTKPRDGGLNDPLLGSIDRQFKCKTCNQPMGECPGHFGHIELAKPVYHPGFIKKVKKILEIVCHNCSKVLADTSDPEFVAAINTRDPKLRFSRVWTVCKKKKRCENEDRQNKDKDEDFAPGLKQPLAVENHGGCGNVQPVVRQAALQLKAGFDVVQEDGPKKKDTAPITPEMAHSILRRISLEDLRNMGLNSDYARPEWMILTVLPVPPPPVRPSISMDGTGTGMRNEDDLTYKLGDIIRANGNVKQAIREGSPQHIAKDFEELLQYHVATYMDNDIAGQPRALQKSGRPVKAIRARLKGKEGRLRGNLMGKRVDFSARTVITGDANLSLHEVGVPRSIARTLTYPETVTPYNIGKLHQLVENGPNEHPGAKYVIRSDGTRIDLRHHRRAAQISLEYGWKVERHLMDGDYIIFNRQPSLHKESMMGHRVRVMPYSTFRLNLSVTSPYNADFDGDEMNLHVPQSEETRAEIRELCLVPKNIVSPQKNGPLMGIVQDSLAGVYKLCRRDTFIDKEMVMNLMLWVPNWDGVIPPPAILKPRPRWTGKQIISMVIPQEISLHTPEGDSDIPLNDTGLLIQSGQLMYGLLKKKSVGSAAGGIVHLCYNELGPDGAMAFLNGVQQVVTYWLLHSGHSIGIGDTVPDKQTIEKVQVHIDTQKAEVARLTAQATANELEALPGMNVRATFENKVSMALNQARDQAGTTTQKSLKDSNNAVTMAESGSKGSSINISQMTALVGQQIVEGKRIPFGFKYRTLPHFTKDDYSPEARGFVENSYLRGLTPSEFFFHAMAGREGLIDTAVKTAETGYIQRRLVKALEDLSARYDGTVRNSLGDIIQFLYGEDGLDAMCIEKQKLGILKMSDAAFERKYRLDLANPPEWFKTDYEYGNELTGDKASMSLLDEEWEALRRDRRETRLINRPKMGEEMMQLPLNIGRMIETAKRVFNVKATDRSNLRPSDVIPAVQSVLRNMKIVRGTDHISEEADRNATILIKALLRSRLAFKEIVKEHRLNKLAFDHVLGELQSRWDRSFVSPGEMVGVLAAQSIGEPATQMTLNTFHFAGVSSKNVTLGVPRLKEILNLAKDIKTPSMAVFLNTTLGKQEEAKKLRSLVEYTNLRSITSVTEIYYDPDIQATRIAEDMDMVESYFLIPDETQDTLDQQSRWLLRITLDRQKLLDKEIRIDDVAQRIKEEYPNDLAIIFSDNNADEQVIRIRTIKQDDGKDEGGAEKRIEDDVMLKRLEAHLLDTLTLRGVPGIERAFLTKGTRLVESADGSELAIKDDARCTQWYLDTSGSALREVLAVDGVDPTRTYTNDLWQIVEVFGIEAARSALVKELTNVLAFDGSYVNHRHIALLTDVMTYRGTISAVTRHGINRADTGALMRCSFEETVEILLEAAATGELDDCRGISENVMLGQMAPMGTGNFDVFLDPKMLETVISDNSRMGLMPGMPAKEGEAEGAATPYDTGSPMADSGYMSLSSPAAGNFSPIQGASSDAQTGFGTEYGGGGGGGGGGGGGGGGGGGFGGIGSLSPYQPRGAASPFNTSPTSPFGPGMGAGGYSPSSPSAGYSPTSPLIDGGRYAAASPSFSPSSPSFSPTSPMLRPTSPASPNYSPTSPSYSPASPSSPRHYSPTSPAQFNSPTSPSYSPASPSYSPASPNLHGGAGGATSPNYSPASPSWSPTSPEAYSPTSPGFSRSPGNQQSPTSPSYSPTSPSFSPRTPGPGSSGNQYSPAND</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LD99</accession>
    <name>A0A367LD99_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_1125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LD99"/>
    <dbReference type="OrthoDB" id="5235700at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="230"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI12399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="325" mass="34576" checksum="C59423F088B65E49" modified="2018-11-07" version="1">MEPTTNRMLIPTPDCNSYLRGPSPRAWTTMAQSGLALFAVVVILRFCLVRLLSSCRWRRRQPRRRSGRSGGGTTWRREAELLGFLDDEDEEASLEAPQKIDCFPSFSSSTAPDEKMKSSHQRQDEDEADDKTDADGLDVVVAMDGRPASDPSPPPPPPPPPAPPPPPFLLSLPLPAPPLTPPELSSAIFTVDDDAPHRHDSFIHQPNPDYLATTSPVFLPALPALPAPGPAAESSSPLSSSSSSSSSSSSSSSSSRPPPPPPPPPPALQPLRRDVDVKGEIISVLDHEGTGWTRHTRVYGGGVCLACAAAGGGFYGATVTPEEMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDC9</accession>
    <name>A0A367LDC9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">BAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_0989</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDC9"/>
    <dbReference type="STRING" id="1330021.A0A367LDC9"/>
    <dbReference type="OrthoDB" id="2159336at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07599">
        <property type="entry name" value="BAR_Rvs167p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000048">
        <property type="entry name" value="BAR adaptor protein RVS167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000189">
        <property type="entry name" value="BAR adaptor protein RVS167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF1">
        <property type="entry name" value="REDUCED VIABILITY UPON STARVATION PROTEIN 167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="BAR" evidence="7">
        <location>
            <begin position="17"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="6">
        <location>
            <begin position="368"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="274"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="303"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI12429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="427" mass="48783" checksum="43A914DDE05B6D7D" modified="2018-11-07" version="1">MSFKGFQKSITRAPQQIRSKFNIGEHTKDAVYIDAERRFQELETETKRLHDESKKYFDAINGMLNHQIIFSQAMTEIYKPISGRVSDPDSVKIEGNPEGIRACEEYESIVKELQETLNPELEMIESRIIRPANELLDVIKVIRKTVLKREHKRLDYDRHRATYKKLQDKKDRSAKDEKALWKAEGEVEQATQDFDYYNDLLKDELPRLFVLEQNFIQPLFQSFYYMQLNIFYTLHERMQRCDIGYFDLTRDIEEAFLEKRGEIQDRAESLAICRFKTTGRPRPQRPSGRPAIEPGKKPALLTAGPSASSSKAGAYSRQSIDSAEQQAPPPYSPTSTPSSPPGGLSAMAASKPKPPPPKPKPGRLSVVPAVETVTALYDFSAQTEGDLSFRAGDVIEIVQRTDNENEWWTGRLQGKQGQFPGNYVRVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDD6</accession>
    <name>A0A367LDD6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Beta-mannosidase A</fullName>
            <ecNumber evidence="5">3.2.1.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Mannanase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L249_0239</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides.</text>
            <dbReference type="EC" id="3.2.1.25"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 2 family. Beta-mannosidase A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.25" evidence="5"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDD6"/>
    <dbReference type="STRING" id="1330021.A0A367LDD6"/>
    <dbReference type="OrthoDB" id="2866996at2759"/>
    <dbReference type="UniPathway" id="UPA00280"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004567">
        <property type="term" value="F:beta-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000084">
        <property type="entry name" value="Beta-mannosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036156">
        <property type="entry name" value="Beta-gal/glucu_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054593">
        <property type="entry name" value="Beta-mannosidase-like_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050887">
        <property type="entry name" value="Beta-mannosidase_GH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041625">
        <property type="entry name" value="Beta-mannosidase_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006102">
        <property type="entry name" value="Ig-like_GH2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730">
        <property type="entry name" value="BETA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43730:SF5">
        <property type="entry name" value="BETA-MANNOSIDASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00703">
        <property type="entry name" value="Glyco_hydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22666">
        <property type="entry name" value="Glyco_hydro_2_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17753">
        <property type="entry name" value="Ig_mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49303">
        <property type="entry name" value="beta-Galactosidase/glucuronidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <feature type="domain" description="Beta-mannosidase-like galactose-binding" evidence="14">
        <location>
            <begin position="20"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 2 immunoglobulin-like beta-sandwich" evidence="12">
        <location>
            <begin position="271"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-mannosidase Ig-fold" evidence="13">
        <location>
            <begin position="846"/>
            <end position="930"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF17753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF22666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCI12427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="934" mass="103823" checksum="139D9CB90AAB13DD" modified="2018-11-07" version="1">MKPSIISGVVRLLELSQQPWQLKNDRLAISVAGAVPSHVHLDLQRAGIIEDPYRGLGEFSLRWVAWSNWTYVTHLDGLLSRKQKTHLIFDGLDTFAHVFLCGEQVGSADNQFRQWRFDVSDALDDACGDDGLVELRVVFASAPEAATRRASEPGAVTWPRGALDGRFVFADRQFVRKQQSDFGWDWGPAFAPAGIWQDGWILQLPDRAAVAVPAASLDIYRLGQLNNLPPDQGADWLLNCSLDIVGSVPDGARMSYSVAEADSGRVVAAGRLHNVTLGGDVISGQVLLRASAFRLWWPVGMGRQNLYAVTVDIVDDGARILASVTKRTGFRTIVLNMGVITEQQLAQGIAPGNNWHFEINGHEFYAKGSNLIPPDAFWPRVTPERIRSLFQAVVAGNQNMLRVWASGAYLPDFVYDLADEMGILLWSEFQFSDAFYPVASGFLENCRREAVYQVRRLNHHPSLALWAGNNELETLGLGQVNETAPDEYPRLLRDYESLFLDTLLPAVYGNSRSITYMPSSTNNGYLSISFSRPMPIVQRYNNKIDGHVYGDTDYYNYRFADAFDLDKYPVGRFAAEFGFHSMPSLATWREAIVDRDQLTFNSTTVVLRNHHYPVQGLAPNPANSSRGMGEMTMAVQHYYPAPNKTDALGNFSAWCHATQIFQADFYKSQMQFYRAASGFRERQLGSLYWQLEDIWQAPSWAGIEYGGRWKVLHYVARDIYRPVIIAPLFNKTSRVLDVYAVSDLWTDVAGVATLAWIGWDGRPLDAFPRGRQQQQQQQQTTVHFTVGPVNSTRLASFHVDTVVEGAPPGLLVANLTARGTPINGDATRTYTHTNIFTPTPLAAVALPDPELSIGYEGERDGFRVVAGGGGVSVWTWISVAPQDAASVVVVFGDNAFLLRPGQHKVVGYTVLSGESSGWQKRVTVESMYNNTLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDI9</accession>
    <name>A0A367LDI9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription initiation factor TFIID subunit 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_0279</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDI9"/>
    <dbReference type="STRING" id="1330021.A0A367LDI9"/>
    <dbReference type="OrthoDB" id="341924at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07979">
        <property type="entry name" value="HFD_TAF9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000069">
        <property type="entry name" value="Transcription initiation factor TFIID subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003162">
        <property type="entry name" value="TFIID-31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051431">
        <property type="entry name" value="TFIID_subunit_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068">
        <property type="entry name" value="TAF9 RNA POLYMERASE II, TATA BOX-BINDING PROTEIN (TBP)-ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48068:SF4">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02291">
        <property type="entry name" value="TFIID-31kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="264"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="36"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="78"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="318"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI12302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="33395" checksum="160ECFF9881B7684" modified="2018-11-07" version="1">MASTQPQTNGASANSSQTITNSQPPVAAATAAQTAAPPPPPPPPPPPPPPPPPPPPPPPPTASQPQPPPSSSGGGFGAAAAAAAAASSTTAPPPSSAAAAAAVGAAPPTTANPTATTASDPRPRDSRLIELLLTSQGVTAYEQRVPLLLLDFAYRHASAVLSDAIHLAGDPHVTQAGGKPAASSGAIATSSAEAPITANAIKLAISARLSYQFRGGSAGGGIDKEHMQELARDRNKVALPRIVPNEWGVRLPSERFVLSGTSWGLKDMWEGDGPDDDDDDDDDDDEEHQDGDAMEGVQGPDPEDIGGDGVEGGTVEDVFGDDVDEVMEENG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDK3</accession>
    <name>A0A367LDK3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDK3"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="144" mass="16384" checksum="C1D7AC5FB5F1B017" modified="2018-11-07" version="1" fragment="single">MRDWNESVQEREADERWKREREEKEREALPGKGVEDCMYVPDDLHQRTNTEAGYREGGGGEGLWIPGWHRHQGSAVRPAADPLSPSSDITTKRRLRATLWQRRCVYPHVSKTNNGDRSQASLRMGGGASPHFTMASGASQRRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDN5</accession>
    <name>A0A367LDN5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_1186</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDN5"/>
    <dbReference type="STRING" id="1330021.A0A367LDN5"/>
    <dbReference type="OrthoDB" id="410920at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000640">
        <property type="entry name" value="Serine/threonine-protein kinase PRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="303"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="122"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="179"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="179"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="275"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="452"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="456"/>
            <end position="457"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="486"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="8">
        <location>
            <position position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI12534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="642" mass="69865" checksum="CD2C68ED334FBE42" modified="2018-11-07" version="1">MGDDEASASASASDSAFVFASADSSALSPPNRDPPRLGLAKPLRISTEQHALYPAAAAAAAATGLSPSRVLAHKASNGSLHLVSRTPSLRSAVAHGLGSTTGNSSVFPSPVITAMGNMTPLPSPLLSGDSPGPWSKLSIGSGSPPMAHRSSNGETASAALAAKRKLYSATDAIDFIPHPQSQEKQQQQQQQQQQQPSPPPPPPPQASHQRNRSVSDYTPEMVAAPKRPVAVSGSHLKMDTTEHDESRMKREFNFADSRGLTPTVTQPPTPPPSESSKDSADVKPKDPEFFDARARADGKIRRWRSIGYLGQGTFSQVMLATSQLASNGSSSEQSATARPVTPTHVDRKKLVAVKVCEHGPRGGSSEERVEMSLKRELEILQDVHHPSLVHLLAWRIEPTRAILVLAYSPGGDLFDVATAHQDALTSPLLRRIFAELVGAVRYLHNQRIVHRDIKLENVLVNLSTAQLRDPRMDWAMFPQSVVTLTDLGLSRRITDGEKLETRCGSDDYAAPEVIMGQPYDGRATDAWSLGVLLYALLEARLPFDPHPGMSDAHRMRSRTSHRIARVEWRWVEYAGDEGEHEADVAKFEQRGLLGAMEITEGLLKRARNRWTVEQVAAQPWVRDAIRVDGGLNFWEAEDGKEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LE08</accession>
    <name>A0A367LE08_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_0554</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LE08"/>
    <dbReference type="STRING" id="1330021.A0A367LE08"/>
    <dbReference type="OrthoDB" id="5600002at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12610:SF12">
        <property type="entry name" value="SEQUENCE-SPECIFIC SINGLE-STRANDED DNA-BINDING PROTEIN, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12610">
        <property type="entry name" value="SINGLE STRANDED DNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="97"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="242"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="453"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="558"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="823"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="267"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="369"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="403"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="473"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="576"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="605"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="651"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="682"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="697"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="747"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="775"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="833"/>
            <end position="842"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI12659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="842" mass="89229" checksum="8BF0E810B272AC4A" modified="2018-11-07" version="1">MAMNPNVGAANMNPSMGGPVGGAPMPMMNNVAANPQAANAAAVAAARQQQIHDRPQQVNGDQRAVLNTYIYEYFIRYGMYECARALLTSDQHVNVLKEGPNRRREDGNVNGSEDAMDTDSKSDLDGKLPDDLPPPKLPMPASDTSFLYEWFCLFWDIYNAQRATGGNGTVNQYVSHTQYQQQSRLKQNQQQELLRQIRPEMAQQHFQAQMMRSMQNGNVNMGMKQGNLARAAMANNQNPQMMMQQAKQNQMQRDPSVMDAGRERPSSPASGDNAPSPSKRQRIDGAPFNPNQPGVMMANGRPGQGIPGQQMASNPSVAAAHQMLTANGINPNSLNPQQFHNFVNAPPAAQQKSIATYSQNIQHHGAQPGNKQMPNAGGPQNQGSPMMTQGPDGTNMGFYNGEMGGPGGMRSGPGGAQAAPGSNHALQDYQMQLMLLEQQNKKRLMMARQEQDGMPAMARDPGGPGGPGAGQVPNGQSFPESSPQTMRSGASPNPAEQMKRGTPQMNSSGIPSPVPDGGQSRGSPNPAMNFMGNHVDQSMGPNFFKGIEGNMAVAQAQMNGGMRPPSSHPGQPFNGQMNPQQMMAARQQQQGQQPQQGQQPGGQGTPQQWQQGPNGQMVPQGMQQQQQQQQQNQQVQGTPQQRSMPPPSAPPGNNANNRTTASPQQAAAAPPTPNQSNKAAPKKKEAKAAKDKRAAAQKKASLTPGNTGTTPAGDAGGDPDGPAPATPITPVNPGFAKNGQNGPVANAQAGGPASAPSASAPGQAATSTSMSQSQGDPNHNGSMNMDNFTGMVDFGGMDLANPLQSGDVLNDFDFDSFLHEDNNEPFDFNGFPGMEGGEIGAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LE40</accession>
    <name>A0A367LE40_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cerato-platanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_0665</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cerato-platanin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LE40"/>
    <dbReference type="OrthoDB" id="4898945at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd22778">
        <property type="entry name" value="DPBB_CEPL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010829">
        <property type="entry name" value="Cerato-platanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07249">
        <property type="entry name" value="Cerato-platanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016850604" description="Cerato-platanin" evidence="4">
        <location>
            <begin position="23"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI12695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="15091" checksum="7C3275225006FF2C" modified="2018-11-07" version="1">MHLLGLFSSLLLLLLLVASASATYVSYDPGYDDASRSLTRISCSDGPNGLITRYHWQTQGQIPGFPNIGGMQGVSYNSPQCGTCYRLSYGGRTIHVLAVDAAYNGGFNIGLGAMNVLTDGNAAQFGHVDADAQPAELSDCGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LED0</accession>
    <name>A0A367LED0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0726</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LED0"/>
    <dbReference type="STRING" id="1330021.A0A367LED0"/>
    <dbReference type="OrthoDB" id="2906425at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF48">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="78"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="260" mass="29662" checksum="D89278E108A12375" modified="2018-11-07" version="1">MVKSSLLISGPIQFDSTFTPVCYEIGVAPEMADRPIKLWTNHEREYHIYPDRFYKRSLRPSEYQLDVRGDPYVPPLGYQRLQNEAACLKFIRANTNIPVPEVLEAYDDNGSFVLITQRLFGVPMSQLPLDSQAIVVKEVERHLQSLRTLRSNRTGGPSGILCPPPRATQYFPGDTAWSAADVPGPGFNLVFCHCDLSQSNIIVHPLTLKIEGIIDWEYGGYWPDFFETQYFRDPRPSGAQFRNHSENARLEDSFVLKHVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEL7</accession>
    <name>A0A367LEL7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_1088</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEL7"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI12868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="65" mass="7344" checksum="999D5CFB76F1D6BD" modified="2018-11-07" version="1">MPSSRRNFYGAYALLEVAKDYIKGLARFSPAFRYVYSYAYASSKHSGITPPCDYASNSFILILFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEN7</accession>
    <name>A0A367LEN7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Magnesium-transporting ATPase, P-type 1</fullName>
            <ecNumber evidence="4">7.2.2.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Mg(2+) transport ATPase, P-type 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">L249_0911</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mediates magnesium influx to the cytosol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>Mg(2+)(out) + ATP + H2O = Mg(2+)(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10260"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.14" evidence="4"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEN7"/>
    <dbReference type="STRING" id="1330021.A0A367LEN7"/>
    <dbReference type="OrthoDB" id="158672at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015444">
        <property type="term" value="F:P-type magnesium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006415">
        <property type="entry name" value="P-type_ATPase_IIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01524">
        <property type="entry name" value="ATPase-IIIB_Mg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01836">
        <property type="entry name" value="MGATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-1278">Translocase</keyword>
    <keyword evidence="9 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 18" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="349"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="815"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="856"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="888"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="920"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="19">
        <location>
            <begin position="46"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00047295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RCI12888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="952" mass="103152" checksum="7978E28C65EC4624" modified="2018-11-07" version="1">MLARFIKLRASRSSGTKSSWPATASWALPPPSACRDDCSPEAVLSAFASAPTDFTLEHLRTDADGLSEPEAASRRSIKGANVLPTQRPPSWIKTLLRAIPNPFNVLLIFLAIINAAVPDRKWASIIVLLVMVTISILVRFWQEYRSSMAVFRLQSSITNKLKVNRPLQSPGSDPKRHQSSTAPVAAMDLVPGDVVRLVPGCVVPADCLILEASFLRISQSSWTGESDPVPKVSSPNGDKEATLFDLPNIAFMGTSVVSGNGLALVLRTGGGQSCIMKALRLLLLLPLTQDVQDVLVANMANELTKKRAPNAFQRGIRHVSYMLIGFMCVMVPIVLGISGKMTGDWNAAALFSVSVAVGLVPEMLPAIVNANLARGAYLLSKMKAIVKRLDSVQNLGAMTVLCSDKLTPSDQTGTLTKDEITLCQFLDYSGSESMAVLKLATVDAHVQGSNGNNIDQAILQHRLRDSSAVGVASYEMLAAIPFTFERRRSSSIVRGATGQKLLICKGAYDEVLSLCSSVRRDGSSVVVLDADIKRDLARQADSLNRQGYRVLVVAEKQLDDVDLEDEDGLNRLESRMTLEGMLTFIDPPKEDAAESIADLKTLGVQVKVLTGDSLPVALNVCQALGLVGRDDATEDDVQATTGPELAPLQGTAEFDAVVKACSVFAKLTPQQKALVVGSLREGGDCVGMLGDGINDCMALRRADVGISVDSGASVAKECADLILTEKGLGIIVASVKTGRVTHGNTIKYIKMVASSNFGNVFSVLAASAWLPFQPMLGLQLLAQNLLYDISQIAIPWDRVDDDYVLRPKRWNTWDLLRFVVVLGPTSSVIDILTYVIGWFFYGIRQADDPKVKTFQAHWFLQGLLTQTLIVHLLRTAKVPFVQSRCTKPLALSTAVIMAVGFAIPWIPPIRDGLGMGRPEATYVGFLVAELLLYCVEVQLVKMVYVRLFKTWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LF85</accession>
    <name>A0A367LF85_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_0196</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LF85"/>
    <dbReference type="STRING" id="1330021.A0A367LF85"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI13083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="518" mass="59481" checksum="F0D8124C9814BAA5" modified="2018-11-07" version="1">MQTLPQAAMRHLLSMAERLGPWHYLLLALVAYTLANLFWLIIYRLYLSPVAAFPGPFLAKITNWYEFYHNFIHTGMYYRRIREMHDKYGPVVRVSPEEIHIMDSTAYHKLFVTGSTRKTNSYPTFSNGTGFEDMTAISEDHNAHRRLRSPLDRLFSRQSVLRFESRVVARAERLCDRIAAYRGSGQVVNLTNAISSLTTDVISSIIFEEPSDYLGDDRFNEEWYETLKMGTLSVPLFKRMSWIRGRLLRFLVTRATRWTVWDEKARRQIMLIRKRPSDKAKTRDETTVLEHLVRSELVEKEFGNGGFARLAQLIQQAGAHNVSHTLSTIITHLLLGKEKLDHLRSELDLIWATTKTGDPSWLELERAPYLSGCVNEGLRMAIGGMNRTPRVFPDDDVKICSWVIPKGTPISMSTYWMHNDPDVFPNPESFEPTRWIEAEPDRLKAMQAHFVPFAKGSRACVGQNLVHMQLYHTLARIFRPGAPELTLHDTTLRDIVAVHGLLFPLPPLDSNGVRATIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFH4</accession>
    <name>A0A367LFH4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_0443</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFH4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI13002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="99" mass="11088" checksum="A1B1DC234451EBE4" modified="2018-11-07" version="1">MLVYDLYNGEDGWIDVVDVVETKGTFFKSMFYPSSTKEKKMGRNGNKLDIAPSAYSQVRHGKGQLYYTAPPPPLTFGEYDLTVSFFGDDEGSDDGWLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFZ5</accession>
    <name>A0A367LFZ5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SRm160/300 splicing coactivator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_1201</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LFZ5"/>
    <dbReference type="OrthoDB" id="5408934at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056416">
        <property type="entry name" value="DH_2_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056222">
        <property type="entry name" value="PH_23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056223">
        <property type="entry name" value="PH_24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24340">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24344">
        <property type="entry name" value="PH_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24345">
        <property type="entry name" value="PH_24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DBL homology" evidence="2">
        <location>
            <begin position="774"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="3">
        <location>
            <begin position="985"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="1365"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="690"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="745"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="968"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1117"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1496"/>
            <end position="1552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1570"/>
            <end position="1604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="38"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="697"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="709"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="758"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1123"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1186"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1200"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1293"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1304"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1339"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1496"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1540"/>
            <end position="1552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1580"/>
            <end position="1604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI13339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1748" mass="189815" checksum="F71B3330589F5AEA" modified="2018-11-07" version="1">MPTTNRLKRDDQNASPEIATSKPSHGLRPSRDDGNTASPTTPSPKKTPGLKTTPKSAPAAMANRPRAANRKPPEPTLLTDFLRGRPSPARIAAQRKRRLSVEAVKAELRQEMRRNSVRRIPAPGGVRQRVQAWQKANASATEKGDPDEAATEPTDLAFVDDDQESVTEEDRVRIKMRAPKPAPKPTPKPAEQKAKPAEQKAKPAASPTAGPPKKRVVSDDNWRKQKGRKSPPRQVTPKVCQTPSPKPRLTPTDFVHRSAPNLPVSIKVKAWAAKVDAADSTPPRSRPSPKSKAAGTLPGRKLGDDGADPNDADAGSKDEECCRKKTKALKPRTRPSLMSEREASEAGKSPSQQSFADRSLGGDEADIIQIIEDPEFVIETPTRTTGSKRRVKNHKPRNAASPSDKALSPNSTMLDLTSSLANKSMADITGEIPFGHSAFSELDVSGKTRPKRLKEERYSHKSMPSVFKKVMEEGKKIIHDINEPPRQPLGNTPPSIENWLKNTVDPFVDSATTKRSGSDDGKSADKVKTRRTSDREAKHTPPQPTPASEDAESPKARPSPSGSSETAKRTADEAKTPSPGGLQRRRATRGTSSPLRSGGRRPLLAVLKEAFHGESTGHSTQPKSYQGHEERGYDSQENEAPTTHCSPDHASTGRLYNDGPHHLIDDGMLAEDIMPAPLKTRSPKRLSTILSEEDSSALGSDLTSDVARSTVTQSTTTTGSSEPPAAPSLQRRLTRHADLVSMLSLPENASMPSGMKDKRSRPSLRRTARGPAPDVTADELLQEFVDDENLYVRELKTLVDGVVPVLLSHVLDGARSTDLFGSNSTTNDGLCKAVVGMGVALEKLKNAHRKAPVSDIRRLSNWAHGLVPIYNSYLNAWRLGFEDVVVNLAPAEGSCGDDDSLLNALPRNDSGDVVNAQGERVAVAYLLKRPLMRVKLLARLFQCVDSLIGSADTRDLARDFGDLEAKARRRHREETARMTDEDAIKTDTSRARDLRTLEPATDSVEIDGNRQVSAKDLFSLSLAHSNGQRLECRVELVHRDRQSDANDQGDLLVREISDGPRSFLLFSPFSLPTLSARVGRSSSELILMARGSHDDGQPWHELLVLTGDGEDQIRDWLDLIPSSPTPPLDMEPIPPYSPETLSDPSAEMASKPLGPRPPTPTAQDSPTPSTPPDARRTLPSRYRPRASTTSSQPSWTPGSDEEHLAKTPTRHDWDRGDRSRPLKESMRPDPSTLCPDNSSTPRPLPPPPLHRSAVASPWHMEVSSPAFPAEPPKGGGGVKRRGSSPLKHEYLPSDTSSASGTYSSDDDFDSDSSDDEIESIDIPETELGVSIRQGKGSEVSESTQSLTPSHSASQTGWQDRKTVPGRRAEQFLASISRWMDKGAWKDISAEPCHVVVTAGLVEAYNARKVYTAQAGSVKPLLALDLTPLVLIRQSTALDLEVRSSVQPHCLLHATHNGGNFRFRCHNAPDCFSLYMSVHHARLNNEKFKQLENEARFRSFGERKTPADGDRGSGSRQRNWFGRRDSYRGSVRAPSQSQDGASSTPSSTPSASSFLRKLTLSGNSSFNIARSSVDRQGGRSCGQSLYTMGSSSSGGTPLRSPSASVACQTGSGGDSVQIRLHLLVAAAKWEDLGNCTLQVRRPPRGWHQALRANHGLEKRVTASTIAKKEGEEAKVVLDAVLGSGCFSAMGSRGIVCGVWEEVKDGDGVSGMAPATGATGGNIKKWCFQFPTVAEASLMLRLLHQEVLRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LG43</accession>
    <name>A0A367LG43_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15 20">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="15">IMP dehydrogenase</shortName>
            <shortName evidence="15">IMPD</shortName>
            <shortName evidence="15">IMPDH</shortName>
            <ecNumber evidence="15 20">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">L249_0281</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Part of the gene cluster that mediates the biosynthesis of mycophenolic acid (MPA), the first isolated antibiotic natural product in the world. Does not play a role in the biosynthesis of MPA, but is involved in self resistance to MPA, since MPA acts as an inhibitor of IMP dehydrogenases.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 15 20">
            <text>IMP + NAD(+) + H2O = XMP + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="15">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15 20">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotetramer. Seems to be able to form heterotetramers composed from more than 1 of the 3 IMPDH gene products (IMD2-4).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15 19">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="15 20"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1330021.A0A367LG43"/>
    <dbReference type="OrthoDB" id="416622at2759"/>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04601">
        <property type="entry name" value="CBS_pair_IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000007">
        <property type="entry name" value="Chromosome 19 SCAF14664, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911:SF111">
        <property type="entry name" value="INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="INOSINE-5-MONOPHOSPHATE DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01240">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
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        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 18" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 15 20" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="5 15 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 15 16" id="KW-0520">NAD</keyword>
    <keyword evidence="9 15 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 15 17" id="KW-0630">Potassium</keyword>
    <keyword evidence="7 15 20" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="21">
        <location>
            <begin position="118"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="21">
        <location>
            <begin position="189"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="15">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="453"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15 16">
        <location>
            <begin position="283"/>
            <end position="285"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15 16">
        <location>
            <begin position="333"/>
            <end position="335"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15 17">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15 17">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15 17">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="373"/>
            <end position="375"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="396"/>
            <end position="397"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="421"/>
            <end position="425"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
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        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>IMP</name>
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        </ligand>
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        <location>
            <position position="520"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
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            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00048028"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00058020"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00062187"/>
        </source>
    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="538" mass="57293" checksum="0C5924FA53E07ADC" modified="2018-11-07" version="1">MATTTKTSVEDHRRALDILAEYKTKDGLDIHQLMDTTKHGGLTYNDFLLLPGYIGFPASEVALDSPVTKRVTLKTPFVSSPMDTVTEHDMAIHMALQGGLGVIHHNCSADAQADMVRMVKRYENGFILDPVVIHRDLTVGEAKALKEKWGFGGFPVTENGKLGSRLLGIVTNRDIQFEEDVNQPVSSVMVKDLVTAPDGVTLIEANRILAKSKKGKLPIVDRENNLVSMISRSDLTKNQHFPLASKLPDSKQLICAAAVGTRPEDKMRLKKLVDAGLDIVVLDSSQGNSIYQTEMIKWIKAEFPNLDVIGGNVVTREQAASLIAAGVDGLRIGMGSGSACITQEVMAVGRPQAAAVYSVSHFAARFGVPCIADGGVQNVGHIVKGLALGASTVMMGGLLAGTSESPGTSFVSREGKVVKAYRGMGSIDAMQDSKAGAGAAAADSQRSNAGTARYFSEGDSVLVAQGVSGSVAHRGSVAKFVPYLAAGLKHSMQDCGMKSLDELHEGASKGDVRFEIRTSSAQLEGNVNMEAYEKKLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LG94</accession>
    <name>A0A367LG94_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sema domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5656</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LG94"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001627">
        <property type="entry name" value="Semap_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51004">
        <property type="entry name" value="SEMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sema" evidence="1">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="104" mass="12046" checksum="C01765C9EEC3A345" modified="2018-11-07" version="1" fragment="single">STVFIPFRKALNLAYSNLAKTCYKDIGTFSRKKGEFSAFLTNLKDKIRTNKATFRDKENRIGFLFCSLDSKAYKTLKTYLLTKTKDNNLSYKDFCGYVKDSVYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGI6</accession>
    <name>A0A367LGI6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5533</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGI6"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="183" mass="18246" checksum="F45EED4C7E813AA9" modified="2018-11-07" version="1">MLLALSEQGGSGSSSRSDSSRSSSRSNARPGGEGGRASPPPAIGGEEGGKRAKLAQKAAAAAALIAATAGTNDFARNEAEDANADSDDKHCANASADDDKRLADATANSDDDYYTNAAAEVDNHANGAADADRAEAVAATAIAVADAAAAREAKKAVFTAAMRAKRREEACRAAKKAAAPALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGL2</accession>
    <name>A0A367LGL2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA N(3)-methylcytidine methyltransferase</fullName>
            <ecNumber evidence="4">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_5471</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">S-adenosyl-L-methionine-dependent methyltransferase.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the methyltransferase superfamily. METL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="4"/>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGL2"/>
    <dbReference type="STRING" id="1330021.A0A367LGL2"/>
    <dbReference type="OrthoDB" id="417697at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052735">
        <property type="term" value="F:tRNA (cytidine-3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000221">
        <property type="entry name" value="Methyltransferase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026113">
        <property type="entry name" value="METTL2/6/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809:SF11">
        <property type="entry name" value="TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037755">
        <property type="entry name" value="Mettl2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 12" evidence="6">
        <location>
            <begin position="152"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="23"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR037755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI13566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="349" mass="40193" checksum="EDAE75345C167E0B" modified="2018-11-07" version="1">MTTDADGSPSRIPADELVALTMTSPDNVAVSEPEVPPHRSHDPVKNWKRSDPFQFGSRFLTEEDDVFEFNAWDHVETDDAYKEYAESQYEVQRQAPVSDFDKNRFNSNPAKWWNLFYKNNASNFFKNRKWLQQEFPVLAQVSKEEAGPRIVLEVGAGAGNTAFPLLANNQNPHLKIHACDFSKAAVEVMRKHEAYDGKHIQADVWDVSGDSLPPDLDEDSVDVAVMIFIFSALSPTEWQRAVRNVHRLLKPGGLVCFRDYGRGDLAQVRFRKGRYLEENFYVRGDGTRVYFFDTDELANTWSKTSPEDGEEAVPMFEIENLQADRRLLVNRAKKLKMYRCWLQGRFRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGP6</accession>
    <name>A0A367LGP6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">mRNA-capping enzyme subunit beta</fullName>
            <ecNumber evidence="8">3.6.1.74</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">mRNA 5'-phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">mRNA 5'-triphosphate monophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_5551</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">First step of mRNA capping. Converts the 5'-triphosphate end of a nascent mRNA chain into a diphosphate end.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67004"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
            <dbReference type="EC" id="3.6.1.74"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:67005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer. The mRNA-capping enzyme is composed of two separate chains alpha and beta, respectively a mRNA guanylyltransferase and an mRNA 5'-triphosphate monophosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the fungal TPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.74" evidence="8"/>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGP6"/>
    <dbReference type="STRING" id="1330021.A0A367LGP6"/>
    <dbReference type="OrthoDB" id="272147at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031533">
        <property type="term" value="C:mRNA capping enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140818">
        <property type="term" value="F:mRNA 5'-triphosphate monophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004651">
        <property type="term" value="F:polynucleotide 5'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07470">
        <property type="entry name" value="CYTH-like_mRNA_RTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.10">
        <property type="entry name" value="mRNA triphosphatase Cet1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040343">
        <property type="entry name" value="Cet1/Ctl1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004206">
        <property type="entry name" value="mRNA_triPase_Cet1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037009">
        <property type="entry name" value="mRNA_triPase_Cet1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28118:SF1">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-TRIPHOSPHATASE CTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28118">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-TRIPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02940">
        <property type="entry name" value="mRNA_triPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="CYTH-like phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="4 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="mRNA triphosphatase Cet1-like" evidence="10">
        <location>
            <begin position="504"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="442"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="128"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="275"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="325"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="365"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="469"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI13588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="789" mass="87254" checksum="6F9D16887A91C5EB" modified="2018-11-07" version="1">MDLRSVLNTADNGDPPSPPSPQHHHQQQQQQQQQQQQQQQQQQQRLSQSPAAGRPYYREYPHPHPPQQHAPGSFATQSGHSQYPTRPAPQIQTQPLQPSFHDGRSPMSAQSPYRPTNTPGAAFPFSPAQPSLSSLLFTTDSAADIKSPSQRHQYPPGPYQHQIPLPQQPRRRDGPPVFTQQQQQQQQQQQQQQQQQQQPQQLLHQHQRSLSTHSSASASTSTPASAHPSAHPPPSHPHGSSPVTASPDFARQHHPSVVPAWPSTGSFARPPSPQPQRTAQQQSTTPDQVLPTGQRVSSAHGPYDSPVSDAPSGRPLSRPEREHSVSVSPHTRVASLSSNPPSELDRRPNRIAMTADGAVTPAKRKLQDRSMSPHELEQHRIPPAEANGGRKSASPVVAPRKRRVYGAAQMPIWAQNARFLAHKALTQGNFVLQKRVHAQMNGTKADASTAPPVAARADRPTVAPSPDTPRAQPVPTAAAAAPPPVEPGLLGPWEASITGVKPYEEISKTVADFIFIHVVNHPDSQEIASRGIQFEIEAKLGTLIDKDTNCRVDRLLDTESVLHDTGRIAFRSSMTEAHHKAFNDFLNQVVIQTDPRAPGGNSRVQVLYKHRREVDRFFDLPPDQQGHIPGCMRPWPGTTRGRNVRVRVTYDQKTREVLNKIIKARVADLDLHMPTCPMDCRLSINLEMAWDGATEELEQSGAGNADRNKDRLSYTQGHYQVDLTQVTQTSGKAQRFEKEHELEIELAAGTVIDQGTKAMKGAPQRYQELIEGLVDNVRVLARKARDFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGZ4</accession>
    <name>A0A367LGZ4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_5452</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGZ4"/>
    <dbReference type="OrthoDB" id="5154006at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="200"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI13669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="393" mass="42633" checksum="6FBCB45D38383B0E" modified="2018-11-07" version="1">MASYSKHDSSCDDGDFHGDSVEGVRSSLADASLNEGPATLVNTDHASAAKARTVADNDSVVSNSQGLTETQGPSIKEPEGAFPEDAKCLDDVKGPTEDADNGLTNGASSPGMVTDGQKPANGKLGYKKVTEATDDVASSIISGSEMYSDDEFEHSDENDDAYTEPSTLGADSTYGACDGEELKKTHDLSERSSMARTCGWSVSDDDLLRGLKRSSKLSWAEIGQALGKTRQEARNRWRKLQWRLMGKTRKAKKNEAAEEASKTGLEESFLPDGEGGDEDEAEELNANYGWPPKDHANHGADEFDGPSDRDVLASEKDGFKKAKWLECQANFMNAAGELVPLYVIRENWLRTERDKELQQQVVDDEQDETRHSGQDENAEATGSRQGGLNEAHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LH66</accession>
    <name>A0A367LH66_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LH66"/>
    <dbReference type="OrthoDB" id="422106at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019416">
        <property type="entry name" value="NCBP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16291">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16291:SF0">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10309">
        <property type="entry name" value="NCBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="417" mass="47686" checksum="5D3820E6F461211A" modified="2018-11-07" version="1">MDLDIEMSDAMEANDDAFDTEPIPADDILQPDEPDEPGEIADDEPQKSSAMVPTKLYIRGLDSLHTDHVKAYVKAHFRAVGAVEWIDDSSANLVFDSPSTAREALAALSSIQLSDTTALEAGETLPAKPLDERPDVSLQVRFSLESDKKRAGAALRSRYYLLHPEHDPEEKRRHGQDIRSRYRDRDDRRDRRDRRDRYDRHDRQDRRDEHDRHDRGRRGSGQYESESFEASMYDDVPRPQRQRRYSEPEEGPRAYARNNREKELFKDRRPRRDRSASPRRRDDDSLADRRNYSSRGNRDEAQSIKNRMSATNKAKELFPGKISGRGGQLDQLERSIGSASLRDEDLPRVATTVESAFSIRGHASRSRDGHEGFSIKGRATSAKELFPEKLGGGGNAGKELLDMNTRKQRQKAQDLFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHU9</accession>
    <name>A0A367LHU9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Aspartyl protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L249_7993</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHU9"/>
    <dbReference type="STRING" id="1330021.A0A367LHU9"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05474">
        <property type="entry name" value="SAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033876">
        <property type="entry name" value="SAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47965:SF12">
        <property type="entry name" value="ASPARTIC PROTEINASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47965">
        <property type="entry name" value="ASPARTYL PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="3" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 11 16" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0732">Signal</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016826074" evidence="14">
        <location>
            <begin position="17"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="15">
        <location>
            <begin position="61"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="413"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="311"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCI13998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="464" mass="48259" checksum="CA93747A5711FE1F" modified="2018-11-07" version="1">MKFVCLLLALGSVAVAVVEQRQRVLKIDFRRGVVVGGRSGGGLRRRDGTVNSTLQNRIGLYTIDIGIGNPPQRISALIDTGSSDALINTNVSQLCEQSSRPCVPSGTYNANASSTSQYINSLFNISYVDGSGAAGDFVADDVRISGKQVRGVQIGVAYKSSSPQSVLGIGLSSNEAQAARGGGRRGGDEYVNFPAKMADDGVIASNSYSLWLNDISAPDGSVLFGGVDSDRYVPPLVAMPMQKVDGKFSEFFITMTSISLNNDTLADNLSLAVLLDSGSTFSYLPNKVAQSVYSAVNARFNDQSGAAFVPCSLASSDASLRFNFSSPASVTVPLRELVIDPTSLSGRPVNFGDGVPACYLGIMPSGGSSGSSANVLGDTFLRSAYVVYDLQGKTIALANTRFNVTASNVQEIPPDGKIPGAEDARDPVRATTGLPGQRSGGTAAGAPFAAVVLALVVSIMIGYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LI08</accession>
    <name>A0A367LI08_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DnaJ homolog 1, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_8090</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI14051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LI08"/>
    <dbReference type="STRING" id="1330021.A0A367LI08"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000005">
        <property type="entry name" value="Chaperone protein dnaJ 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.230.10:FF:000001">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012724">
        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096:SF52">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="9">
        <location>
            <begin position="380"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="10">
        <location>
            <begin position="535"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="7">
        <location>
            <begin position="535"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="366"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="772"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="380"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="783"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00072890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI14051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="827" mass="89138" checksum="6D3161E21FCAD907" modified="2018-11-07" version="1">MHATCFKPEKDIPSLEGKVILVTGGNVGLGKQAILDFASHRPRQIWLAARNVDKANEAIEEIRAQVSEAPVKLLQMDLSSFESVKKAAETFAAESDRLDILMLNAGIMATSPALTKDGYEMQFGTNHMGHALLTKLLMPVMIQTAKDHADADVRVVCLSSIAHKQAPKEGIVFDSLKTEANNMGAFERYGQSKMANILYAKQLAKEYPQLTVSAVHPGVVRTNLASGMSGMPAVVRWMSPLANIFFTPVDQGAKNQLWASVSKGVESGEYYEPVGVGGKCSSVGNSEELAKNLWDWTEEELRGWPNMNTSILHKAVAPIRMLAQSPIVVVVRDYSCKGARYHSPASAFPRPAKRRLITPLARRKGTQRGFHTTGPLRQNDPYQTLGVNKSSSAGDIKKAYYGLAKKYHPDTNKDPTAKDRFSEIQSAYEILSDPQKREQYDQFGAAAFDPSGAAGPGAGNPFSGGFQGFGGKGGGFPFEEIFEAFTGQSSSSSGRRRARSPFESAFNSPFETQEIFVGENIEVFANITFAEAAKGTVKRVTTTPMTPCDSCSGSGLKSGAKRSQCKNCNGTGTRLHFMHGGMQMASQCNTCSGTGSTIPKGSHCTKCSGNGVIRDRVPVQVEIPAGIEDGMRLKFEGAGDAPAMGREANPNSPSQRGDLYVCIRVARDSRFERDGADLRHRASIPFTTALLGGQVDIPTVDGTVKVKVATGTGTGDVQTLSGMGMKRLGKRSGWGDLKVVWRVNMPTSLTANQRTLMEMMADEMGDKSARRVMNVSPSSTQAEGDHNKHEGFLKSIWHSLTKNQPAPPPNTDDTTGGKKKSSDSGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LI17</accession>
    <name>A0A367LI17_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-phytase</fullName>
            <ecNumber evidence="2">3.1.3.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_7960</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.8" evidence="2"/>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI14065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LI17"/>
    <dbReference type="STRING" id="1330021.A0A367LI17"/>
    <dbReference type="OrthoDB" id="10257284at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016158">
        <property type="term" value="F:inositol hexakisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF110">
        <property type="entry name" value="2-PHOSPHOXYLOSE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="70"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="410"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI14065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="537" mass="59576" checksum="536055300D08C9F6" modified="2018-11-07" version="1">MSSLDPRPPYSAAEIATLYPPQLRLQLVQVLLRHGERTPVTARFAKAGLPAFWPYCSAARQLRATVLQELNDREEDEDDDRSTTTTTTTTKTKTETETKTTKTAFSTLEWRRRLETLGKDDAPVKATGPDGELDAICDMGMLTDQGRKTTLALGQRLRTLYINQLGFLPSQIDDGPSQESLFYLRSTPVPRALESLQQAFVGLYPPRQRLPTFQPPVIVSRVPADENLFPNDGNCRRFAELSRAFAQRAADRWNGSQDMAFLTKKLGRWMPDESPVVAVDSRPRLSGIMDSINASRAHGPRTRLPSAFYDPDVKRIVEKIGVEEWYAGYKESREYRALGIGSLLADIVSRMVDSAASSSSLRLGLSGCHDTTLAATLASLGAFETEEWPPFTSHVAIELFRHVDQPCSSTSSSSSSSSSSSSSSSSSSPSSWQLPSWLSLRPRPDPDSLRRKPTPHLGDAERRLLDGYYVRVRYNDTPVTVPGCRAPGKHLDGDDSFCTLEAFKAIVDRFTPRDWKHECRANVKAPAFPSQPEPAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LI36</accession>
    <name>A0A367LI36_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">OBG-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_8037</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI14047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LI36"/>
    <dbReference type="STRING" id="1330021.A0A367LI36"/>
    <dbReference type="OrthoDB" id="347018at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.210.12:FF:000001">
        <property type="entry name" value="GTPase Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.210.12">
        <property type="entry name" value="GTP1/OBG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006169">
        <property type="entry name" value="GTP1_OBG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036726">
        <property type="entry name" value="GTP1_OBG_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045086">
        <property type="entry name" value="OBG_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702">
        <property type="entry name" value="DEVELOPMENTALLY REGULATED GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11702:SF31">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOME-ASSOCIATED GTPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01018">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82051">
        <property type="entry name" value="Obg GTP-binding protein N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51883">
        <property type="entry name" value="OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Obg" evidence="6">
        <location>
            <begin position="74"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="OBG-type G" evidence="5">
        <location>
            <begin position="341"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="29"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="198"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="133"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="227"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI14047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="637" mass="69295" checksum="602B530C32E24C83" modified="2018-11-07" version="1">MASRCSPSPCSSSVAAALFRPRHRRPLMPAIILARHSSSSSPSPSPSSASASASEVNGLPESRLNPRPDDYAAPAFADSARLTLSAGRGGHGCISFLREAYHPDGPPNGGDGGQGGSIYIQAAHGETSLLKLSRQRHIRASRGKNGQGASRTGNRGEDVVITVPVGTLVREIDRRDPIADDLDRFRAFRALKKQKARERREALERKQAEDDQADTSQSPFSHHDENEQVEEEEEEEEEEDIELKNPNRQKWLLYPGMSKSDAQTAIFPPLPRRLRRIQQPDAPIFLDLSRPSIKPILLAAGGIGGLGNPHFTSLDHPRPLFATKGEDAVSMTIELELKLLADVGLVGLPNAGKSTLLRAMTNSRTRVGHWAFTTLQPNIGTVILDRYAGRPIFQPRSHDPDAEARTRFSIADIPGLIEGAHLDRGLGIAFLRHVERAGLLAFVIDLSAGNAVRALDALWREVALYAQMRDDEDRRREAIDWSLAPDPLESTVNLMDVAQDQQLLLPAPREDDGDDHQINTTINTTITTTTTTTTTTTTTTTTTTTTTTTTNTTASTPALNIAGKPWFVVATKADLPNTQTNFAELKAYLDDITAAKVPHPSRLDGAWTGQCAAIPVSAIHGQGVDRIVHWIVNLLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LII8</accession>
    <name>A0A367LII8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_6033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LII8"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="101" mass="11009" checksum="76844FC585CEC768" modified="2018-11-07" version="1" fragment="single">IVVVLSLTLVGSSYKYSQTGPTAIIVTLGRGVLAVGALLVPSCSHIQLSDELLMFIEQQALRYPVRDYFCSADLLEIKIALLVPLNYPFIAHINMPSSLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIL6</accession>
    <name>A0A367LIL6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Subtilisin-like serine protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_8070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI14102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIL6"/>
    <dbReference type="STRING" id="1330021.A0A367LIL6"/>
    <dbReference type="OrthoDB" id="5086500at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046536">
        <property type="entry name" value="DUF6601"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34414">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34414:SF1">
        <property type="entry name" value="SUBTILISIN-LIKE SERINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20246">
        <property type="entry name" value="DUF6601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="291"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI14102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="38939" checksum="3E52BE7BCAEA5629" modified="2018-11-07" version="1">MSASSPPFSRDVSPIVDGRWRRQKGQQAGEQREEIHRISSDLPKRDGFASSLTAQKRPYDDLAPTLYLESGIKGGGTLHTISSAAHYLRLSFDLGRLHHKMMGRDIVVTEQSDLHLTWRESTLFLKPLWKPMLDYDFWEEAICSDDEDVRLSAAGLLLSYVWLICCKADLHIAKQHRLVPRKLRWIDWAALSRDILSRHLRVAERYDYGELRVHRLNLIYRFAPGMFPDYLFRGYLYGYNRFSQFFGRNFAWAAGAVLYASVVLAAMQVALGVAAIKDHPSFQGAAYGFSVFTMVAMVFLSAAALGYLVVVFILNLVYTRNRVKIHRLKRQEGRTPEAIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIM2</accession>
    <name>A0A367LIM2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6192</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIM2"/>
    <dbReference type="STRING" id="1330021.A0A367LIM2"/>
    <dbReference type="OrthoDB" id="4918265at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016735419" evidence="1">
        <location>
            <begin position="20"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="245" mass="27349" checksum="73A13493FB66EA44" modified="2018-11-07" version="1">MFLIKPLLVFLGSLSLAAGFDVPGGWERLMFYHAYLIDCQTHDNKPTTMAPKIKGSKDLNEFIRFIDNVPPETPVAVTKTRFPDLPPLEETAKNIIASGYTTPVAVGRVNTKVTSSNYDILIVRTGEFIYGQVELGRVDEKLVTATRKVISAVNVLRRQAAAKSFFEKAENAKYKPVYKERPLWAGSDTKALVMDGLSTAKANNMESKELYKIFREHLGDGHSNNIHALTDLSERLEALELKKTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIX5</accession>
    <name>A0A367LIX5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIX5"/>
    <dbReference type="STRING" id="1330021.A0A367LIX5"/>
    <dbReference type="OrthoDB" id="10263272at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="333" mass="37168" checksum="409333C3C0A0E124" modified="2018-11-07" version="1">MDSLISLRLSYPRLSCSEDRRPNGDDDDFGAFGLILVSPADPGYGSVDESRQSTGIPTGPQRPLLCLDGDGSWDGPPTLAQEPTCRLIPRPNTRSPGTSSTSWQTPRERGSQTFWGCFGVENSDIPRVQWYGRALYDRDRFVPVRRGSPTATERYHMAGHSRALSLSDRLTIRYEREHRGHLFAMRSIRNLVLGGTAFDDGRGRLLWLGSNARLFTLTSLAARPSAQDELKRYRGRVAVALEIDRVCRILDFASNLSSLIRPAAARTPWDNGRDWPYPERYPDSPSPPRIVLPTAPFRVLDAPCLRDDYYCSILAYSATCQTLAVGLGNVLYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJG0</accession>
    <name>A0A367LJG0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DUF4045 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_6583</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LJG0"/>
    <dbReference type="OrthoDB" id="6375767at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005546">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051014">
        <property type="term" value="P:actin filament severing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008154">
        <property type="term" value="P:actin polymerization or depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025118">
        <property type="entry name" value="DUF4045"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057226">
        <property type="entry name" value="DUF7904"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007122">
        <property type="entry name" value="Villin/Gelsolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977:SF133">
        <property type="entry name" value="DUF4045 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11977">
        <property type="entry name" value="VILLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13254">
        <property type="entry name" value="DUF4045"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25480">
        <property type="entry name" value="DUF7904"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00262">
        <property type="entry name" value="GEL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4045" evidence="3">
        <location>
            <begin position="2"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="DUF4045" evidence="3">
        <location>
            <begin position="180"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7904" evidence="4">
        <location>
            <begin position="1054"/>
            <end position="1153"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="2">
        <location>
            <begin position="1176"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="430"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="449"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="601"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="680"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="741"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="753"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="773"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="810"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="853"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="896"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="945"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="963"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="991"/>
            <end position="1006"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI14540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1435" mass="153199" checksum="61C787A8BC8FB9FE" modified="2018-11-07" version="1">MSDEVSQFLEQVELLRGQQAEEGETRARELEDFLAAKRERQARREERARSISPQKSSPVNTPSPRSSRRAGHQSPTSLGDKHLDLSAPQSAMEPLGSPTKENEAPLDSAEAKRLSTADARSSTLSWQRRPTSRPLSMVAAQNATQRSLAAAHDPSDQTAAGPRQTADVARRGHDDDNTAYVTSPTHDARLGSPVTLKPSQQEPPADDKPPSEQQGVTSPPTGRTSPIRSTSPTKGVGGFVQSAMMKRNDSVKRWSVTSPPGLTRADSVAANRNSHERTNSRPHSTHRNHSPAPGSSRPTSSQGEDDLGQDATVTSTDTDHATKPDDDATIPTSPTRTMDTRRWSPTKSSWLESALNRPESPTKTQPKPKPQPAWMVELNKARAERANSQGTDASRPVTHKHQVSIGGLMRQSPVGEVAKTNPTGLGGIYSPPSTTAPSFTPRGHEAKPSIAESIISEGASETDGSTAAASDTRRPSIVKPKPEPKDFRAGLRQRPAPADAPKSGESELKNVFGNLRRTKTQNYVAPDQLKDNILRGKAALNTTDGPRKTERRDDFKEAILKKREDFKKAQAEGKGVTRSSLGDGGKQPLEGVAKRFELRRSTTGSSTGSTTGSRKGSVVAESTSPKDEAQRSPTALEPATAESPTVTSPPPPSFDKARLEQPTPKDAAGPEAPSSTQARVGGGGGGGNKLAGRLNPALAGMLARGPPPMASTNGGGQGSDESAAGDGSEPTAPGPQLSHMTKSRARGPKRKAPTSSPAPATPAATSGGSEARGAPERATESGEQGRDGPEEKPTSDKPAAAPLSIQQQVAAQAALRNRGAAGKPEAKAAESVKQTSSAAKDEESHVAPTETNGDGKDAGRKVDVKQASRLFDDEKPASVTPPVHRRSGSQSPTKKPLTESEAKGEMKGGNEDGGRKVDVKQASRLFDEKPASVKEATPPFHRRTGSQSPTKQQQQPKDMLETVSKSNGSRPSTPKAKSKGATLALSGDALKSPSVTTSPVRSPSKVASEVSRLLTDFFGPPCPRKEMRVDAAEMLMSRPAGGGSSGKLTSLGFQMFRIFGDGKKIPVSAQNERVLFEQDMYVCAHNFTNEAGKKMFEVYFWVGDEVPQATAEDAQLFVQREAKSLGGKLVRLRQGQESAEFLAALGGVVIVRRGTSNKYDSLAPNMLCGRRYLGQVAFDEVDFSPSSLCSGFSYLLAQSGKCFLWKGKGSDVAEVSCARLVGIDLSLTGELIECDDGDEPASFWDMFDAESPKPVSAAHWRLKPSYDKYRSRLFCSDADSEQQVSFTLRIANEQQHQNSSKQMYEITPFVQTDLSPSHIYVLDAFFELYVVVGAQAKAQYGSFRNALDFAQEYAILAAGIEDRPFVPVSSVVLEGAPRDLKRVFRKWHDRNGPTAAAAAATTAAATTEGGNHAGLKRGRSLRVVTLTQALQAMSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJI8</accession>
    <name>A0A367LJI8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6628</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJI8"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="142" mass="16291" checksum="778F7A1550CE905C" modified="2018-11-07" version="1">MGDESRDLQTSADPVLMRKDSVSFGDADRGGGEAKSPRRSRAEGGRQQGKLIGREGDDDKDEEDEKMRRKTRRRTRRTSGKRESERNMEKEEEEEEEKKKKKKKKKMVRGPAKEKRLPSVQKVTTRQDEGRTDGATRGKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKQ6</accession>
    <name>A0A367LKQ6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Ceramidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">L249_6705</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alkaline ceramidase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKQ6"/>
    <dbReference type="STRING" id="1330021.A0A367LKQ6"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006672">
        <property type="term" value="P:ceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13854">
        <property type="entry name" value="CuRO_1_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13880">
        <property type="entry name" value="CuRO_2_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13901">
        <property type="entry name" value="CuRO_3_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000021">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008901">
        <property type="entry name" value="ACER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF145">
        <property type="entry name" value="LCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05875">
        <property type="entry name" value="Ceramidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016652878" description="Ceramidase" evidence="15">
        <location>
            <begin position="20"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="896"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="929"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="953"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="994"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1035"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="18">
        <location>
            <begin position="185"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="16">
        <location>
            <begin position="311"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="17">
        <location>
            <begin position="599"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="830"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="878"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="1032"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="1036"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR608901-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RCI14842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1088" mass="120141" checksum="A098691198FD08B1" modified="2018-11-07" version="1">MKLSRALLAALCLILPCQADAVPGHDQAVGHDKEAAAPASHGKAAAPPTSPNVAAAHGLSRAHESWAGEAPKGESKFISSENFGFGTTFSRQFLELFLGPDAEHVIKSFSSPFTRFNTGFRPQLSQAVTNGRSRLGSPAQPYFPPFLVNNPMPNGFPWSRFNKYTNYYNEYPRTGVIRRYEWTVSRTLIAADGYLKSVILVNGQFPGPTIEANWGDTIQVTVHNNIRDPGEGVSMHWHGFLQQGTPWEDGVPGVTQCPIPPGESFTYQFDAQLYGTSWWHSHLSAQWVGGLFGAIIIYGPELVPYDFDAGPVLITDYYHKDYFTLVEETLSPFTGGIFLSDNNLINGKMAFDCTLVSARDNRPCNSNAGPAVFEFVRGKTYRLRLINAGAEGLQRFSIDGHKLLVIANDFVPVEPYETTVVTLGIGQRQDVLVKADGPLDAYWMRSNISELCSLTAQPQALAIINYVDRHTTGVRSARNLDSDLSPGIISLANVRIPASIPWNVPDPGTCANDPLAITAPVMRLPAVKPDLIWVFNVDTFVNGSGVTLWRLGGISERTNFNAPTLLLSNLGNYSFDPIWNVRAAVDLTHFHRARGDLGALPQARNVRIVVNNRSPVAHPMHLHGFNMQILNEGVGSWDGSIVRPQNPERRDVYMLQKNGYLAMQFDAINNPGTWMFHCHIAWHASAGFLMQILTNPRALRQFRVPNTVADTCRQWARWTRTNIPNQIDSGLKTFLPPPSPAVNHLCSRGVMDSLETPPVLPMFHPSHPSHPSHPSHPSIYPSIYPLTAAAANLNAASAKRCFVPSTQAQPTQADELISSQDYALTRYIAEFINTLSSLSYVAYGIYGLSNSLQKPQAGPRLASYCGLIAVGLCSAGYHMTLKYHTQMCKCPYTCSLAILLVDELSMHLLATPLLFRLLTFGASPRYTKVVAVVLLLLFTVIMTTHILMDEFLLHATTFGLAVYLIATRIWHIISQQVPDPVIRKNLQRLTKFGCANFLGGYAFWLVDDWACGLLTSMRHTVGWPVAFFLEFHGWWHVLTAIGGYIAVAIVDTITSGELDKDPIYTFAWPIPAAMQYLSGTTRVKAHGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKW7</accession>
    <name>A0A367LKW7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L249_6863</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="4"/>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKW7"/>
    <dbReference type="STRING" id="1330021.A0A367LKW7"/>
    <dbReference type="OrthoDB" id="5632at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032954">
        <property type="term" value="P:regulation of cytokinetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007096">
        <property type="term" value="P:regulation of exit from mitosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14499">
        <property type="entry name" value="CDC14_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17657">
        <property type="entry name" value="CDC14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000038">
        <property type="entry name" value="Tyrosine-protein phosphatase CDC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000073">
        <property type="entry name" value="Tyrosine-protein phosphatase CDC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044506">
        <property type="entry name" value="CDC14_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029260">
        <property type="entry name" value="DSPn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14671">
        <property type="entry name" value="DSPn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0469">Meiosis</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="15">
        <location>
            <begin position="318"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="16">
        <location>
            <begin position="385"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="216"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="302"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="478"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="622"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="307"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="478"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="536"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="622"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="651"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCI15027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="679" mass="75590" checksum="30A92C8FE7CCC008" modified="2018-11-07" version="1">MAPSSRHSMGQVIEYIPDRLYLASYVHPPTRDTPFPGTDGSSSSKKRGGPRSTTTNTPCYFTVDDTLLYNAFHHDFGPLHIGHLYRFAIRFHDLLGAKENKDRPVVFWSAADPRSRANAACMLACYMVLIQSWPPHLALAPIAQVDPPLMPFRDAGYSQADYGISVQDVVYGVWRAKEERCCDLDNFDLDTYERFERVEHGDFNWITPHFVAFASPQHDDDDDDDDDDDDDDDDDNDTSTATTTTLPQPFRNVLQHFAERDVGLVEERCCDLDNFDLDTYERFERVEHGDFNWITPHFVAFASPQHDDDDDDDDDDDNETSTATTTTTLPQPFRNVLQHFAERDVGLVVRLNSPLYSARHFEARGMQHLDMIFDDGTCPPMTTVRRFIRLAHDTIVGKGKAIAVHCKAGLGRTGCLIGAYLIYRHGFTANEAISFMRFMRPGMVVGPQQHWLHLHQGTFREWWVEERVERRLRRELASGVGSNSNNNGLPSTPVRPALQKRNTPAARTPLSEVERGNNNVQDDCLPAPTPGQPRKAGGGGGGGGRCLSSSTEPVVIVDEAGLRSSDDDKDELHHLRATTSCPSTSASSPSRRASGQAVLVIDNDASRDVENVGAAAALRAVAVKHRHQHHQHHHHHDAVVAKVRRRPEPSPTSSSSSPLRGVRKASGRVGSVQRKVSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LL12</accession>
    <name>A0A367LL12_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6405</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LL12"/>
    <dbReference type="STRING" id="1330021.A0A367LL12"/>
    <dbReference type="OrthoDB" id="5865767at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37283">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN YHR131C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37283:SF1">
        <property type="entry name" value="PH DOMAIN-CONTAINING PROTEIN YHR131C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="359"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="469" mass="52492" checksum="9C479DCEEAFFABC0" modified="2018-11-07" version="1">MDRQRPAPPVRRRYSMEEDIFYNQLMGGSKRDPSQPPPYRPHPPPYRPDFDSRPRSMISATVSDSDAADNNNASFASSSSSSSASPSASASASTSSSASSSASRTDESPPRYQSTVNIEGVFSKKHEIEDTIKRAEDRQWHTVFVLLQGTALNVYSVKKDWGWGRTRDGPAVCPDNPPWVRRSKLEKSYSLLHADAGIAADYTKRRYVIRVRAETDQFLLSCIELSTFVKWLESLFAAIGVAAPIDDRDFPRDMSIPRVQRIRWFRGQSPALPGFAAQEMDGLSSAPSLPPPTPPTTPPPPSPPSPPPSRPSPAASPLQPLPPDHQDDDQQHGRHHIGPPETTIRDTDLMRPSSPPPQQQQSQSTVPSRIEPPRRLSTTNYPNASIDPYTGKWFPEHKWSSAHDLLYAKLCYSNLLFRSPRKSNYIISKGKQWVVDWGTGRMVRVLPPAYGEIDYFGPWQVIHTENFRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLF0</accession>
    <name>A0A367LLF0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_6550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLF0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI15248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="177" mass="19451" checksum="AADD8B4A4E54BEBD" modified="2018-11-07" version="1" fragment="single">RSSANGLIHTVSKQWRLEMLSLPYTSNGTPGQHELMNPKWLDLLAGLIKTRRDSFSDATAAEKRGGGLASGRKGNESTTIRFWLSQRELSDGSRAGHTHIKEAMGSLSCLLNFSQSKRSIAFWVGGKEGSSQRETDNKTAFTVCSIASRVKTKRLVKRAAVTLLYDQLPGPFVSKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLI7</accession>
    <name>A0A367LLI7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_6693</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLI7"/>
    <dbReference type="OrthoDB" id="4915089at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI15260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="299" mass="33568" checksum="90EB3ACDFA75142F" modified="2018-11-07" version="1">MPLPTRVLNRRSEIGFTLEYANLGLAIVDFGEYKTSPNALKTARTLINFHSVLAGRSSFSEWGRWLIQDDAKYKRAWFGFSKPTSKQAPSPNADQLEEVERAAKRAGISIIHRDSDLIAEELMKVISYKWGERTVACLEVMMYRQGAFDNALENPVDPSAPAERPELHLPPYLECALCDDGGGSRVLCDLLDRGGNQTLDIPNVMPTKSATEQRACSQYWYAKEQRCIVSAKKLPEFKGRQCWASGRVVECGGGMSASKYLLAKAECYQPAWWREGSATCKAPEPFRFFREIIAGIWPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LM30</accession>
    <name>A0A367LM30_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_3393</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LM30"/>
    <dbReference type="STRING" id="1330021.A0A367LM30"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051775">
        <property type="entry name" value="Homeobox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24323">
        <property type="entry name" value="CEH-10 HOMEODOMAIN-CONTAINING HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24323:SF7">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0371">Homeobox</keyword>
    <keyword evidence="4 5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="8">
        <location>
            <begin position="24"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="5">
        <location>
            <begin position="26"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="209"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="310"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="209"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="406"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="425"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI15493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="471" mass="51637" checksum="A35BD1D334B4FF31" modified="2018-11-07" version="1">MSSTPPSLPWPPVAGCAPDPNNAKHPKGRRKRTATKDKAILEEAYKNDPKPDKEARSAIVERVTLNEKEVQIWFQNRRQNDRRKSQPLSVEEITALRFKTLASPFADFTSPPDDASRFPAQSSPSCNSRFESWIPHRPADDTPGSSFPAPVGYVANRRNLTASSHSAFHHDSSMLQSISDLLSKPIGSPSGIRISLSLGGKAELEWSPARVAPARPSSALPEPSQPHRASLQRSHSAIPLVTLPSINSLDVFRPAPMARGRSRDVQAWESCADSEKRDQLTTQAEHESRGSAIADISLLKSSGAVLQAGSVKRNASVTRPRELKRHKLSRSSSQVEPESSKMKVAMLLSPNDSDKENWSPVQGDQVPRPQAGRRPLPCNAPSKAHNSRRTGGVLEEQKRPRLFHNRANTAPSDFTSTTSKTSCDIYEDPSSDDDDDDDAMKRFLSANVSPSKKGDMDCIAGLLSLSKGNWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMQ6</accession>
    <name>A0A367LMQ6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_2224</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMQ6"/>
    <dbReference type="OrthoDB" id="3943049at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI15724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="83" mass="9223" checksum="746A4D2FAFFC58CA" modified="2018-11-07" version="1">MPNFDFLKSIGATKEAIAVLNDQPNVFATIIAVLIGLGLELLLLWYIHFATLKPEQKKKKKDKKDKKKEKKGKDNGASAAGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMT2</accession>
    <name>A0A367LMT2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_3321</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="2"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMT2"/>
    <dbReference type="STRING" id="1330021.A0A367LMT2"/>
    <dbReference type="OrthoDB" id="5981550at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000003">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase HERC4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.130.10">
        <property type="entry name" value="Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain (AZUL)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032353">
        <property type="entry name" value="AZUL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042556">
        <property type="entry name" value="AZUL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF8">
        <property type="entry name" value="HECT-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16558">
        <property type="entry name" value="AZUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="7">
        <location>
            <begin position="914"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="162"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="260"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="478"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="306"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="479"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="1238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI15746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1270" mass="141788" checksum="49094072D1D78BA0" modified="2018-11-07" version="1">MSPLMHTVGADSRHDAHSRSRTDLLRDLTAGLWQEAPFSRLPDDAPPELRHLVQDIDNPRRVYAIHKASRRHDFQLLVDRYVVQLRTGCASPQCSTSTCFTCRKRLAGKAPVRRYNPTSARTLAVYLASQDSPEKGLCPYLHRSREPPSAVNTLVFSARFASAPPTASKPPHAKGQDSHPKPVRIISRSSHQRRDELNRRSADDGSPSSPKLGMHERPVNKDYRSFAAAAFGTVAFKMLEWLTPQGVEYMSKTLHEVGCPVSSDQGQSSEAVQPEPSLFGETSPKTQKHSHEKPSSNVAHIDAAPSSRNSSTNLHGSRSSCRNHSSPMSNRKASLEPLLEPNVMDGVKPPCRSTTMNGIHLDKRAKMAPGVIARGVPELQLRQPAFFDNVPCPASLSVGDEEEEGLGSAEKIQVNKDNATDPIPGIVEGRLNMPTNADLRDTVLVPDALEIDCLLPQSLRLLDVELVEFVCDTLEEDNTSEKSSLRPDNDAETLPVPQNKPCKLRRRKRPGLSVPKAQWKAFNEQTIFDVLSNPRSLVQSFTRDGKLYDSHTLWYCMLRMTRAAPSVVLHSLWLAASSLFAPPDSLKHVRSQSRSIFDGSVGSLSDFEASCVLSVCLHTLVAAVPCVSDSKTLCEISRIRSNGLVLAAGGIGARQPPSACLDFDDVFSNDLALRLARRLFCVITARQCFAEIVGCESSRVERPESDLDVLFPLLCQLERASSDSVRILEFTPAERRLHETRVPTLLLDWSKTILLQEWDGQAEFSCDSPFFGALSLMATLYEHRTSLVLGDLQFRVDYLSERLDAMEMPVAWVAFTSTRQRRHLLDYPYLFNPETLVNYFRALNFSRMSKSFEESSSLKTRMSAIVDPGSLVTNPHHKKVLQDMLKTASSKFLVLEIGRKNVVRDAFDQLWRRQERELLRPLKIHLGEDGGEQGFDSGGVQLEFFRMAIAECLDPDFGAFAIDERTRAAWFVPGSTVEDWKFEMMGLLVSLAVYNGLTLPVTFPKALYRKLLGQPVDDLHHIADAWPELSSGLSALLDWDETNGLVEDVFARTYEFSVAAFGSDVTRQMTKDDSSWPQALATGTLPKAAAAAEGDEAPLVTKANRNEYVSDYVRYLTDVSVRPQFRAFERGFRVCLDIKSLSLLSPPILQSMVEGIQEIDVSELRRYARYVGWDASHHTVKDMWSVIKHFDDRMKRKLLEFVTASERVPVGGMRNLQFVVQRNGEADEGGHLPTAYTCYGTLLLPEYKDKEVLRERLTMALENAQGFGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMU2</accession>
    <name>A0A367LMU2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3477</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMU2"/>
    <dbReference type="STRING" id="1330021.A0A367LMU2"/>
    <dbReference type="OrthoDB" id="17089at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007849">
        <property type="entry name" value="ATP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28106">
        <property type="entry name" value="MITOCHONDRIAL ATPASE COMPLEX SUBUNIT ATP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28106:SF1">
        <property type="entry name" value="MITOCHONDRIAL ATPASE COMPLEX SUBUNIT ATP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05176">
        <property type="entry name" value="ATP-synt_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="344" mass="38621" checksum="D3418E0A4C688458" modified="2018-11-07" version="1">MESSSVLALTTGMLARYSIQHASPSLRPFSPPAVRQRLLQPLRSLRSYSQAAAAASGAGNKACPKTTTTTKPAGAAIEAPRRYGPRYEGDFTPQPLPRPIGMPQRPRAGENTGIDDRTLSQRRHDLFDRDRNMVRRKELTEQFSRPYFRDWSNLQFHDGKSFLAPPRLFRAEASLYFPNLQGRTLAPKDKTARDTTPLLTGRASVVSVFSSRWAEVQVGSFVSSEANPALHDVVSRSPGGRAQLVHVNYEDNAAKAWLLWLFRGSLRRRFAQADWDKYFLVRRGISDDMREAVGLLNAKVGYVFLVDHHCRIRWAGSGDSRPDERESLVKGLAKLANEVDKEKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMZ4</accession>
    <name>A0A367LMZ4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kelch repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_3284</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMZ4"/>
    <dbReference type="STRING" id="1330021.A0A367LMZ4"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="503"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="475"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="531"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="542"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="584"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI15815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="596" mass="63241" checksum="D11432F563A3EE31" modified="2018-11-07" version="1">MALLCASPLLRGGKTIFFLSFSSCSLPSLPRRSPLMARRLLHALAALSLCGLVSGTLGDVCYIVSAKTALLNNDRLYFMGGKYSIVSLGGHTVSPTPSLYSLLVGNQFPVERPIPQSLLENTTIKHRSASLARTGASAEDGLVLWNTGDTLYAFGSGRRRSSHVAAYSVKTRTWKDVRVAGGAFNFGRRTNAQYVSVPGSDLHFVYGGTSPYMGGMIRFDSKSLSWTNETLGRGSYGTQVPGLEGGVMAYIPAGKEGMLISFGGRNATAAVGSDSDWHIIYVYDIASHTWWAQRATGKPPSSGRGNFCTSVVAAPDNGAFHITTYGGWSQRNGRAYEDLHILSIPSFTWIDATALSDRSNAEQQVNSTIGRDKLGGSCQTLNGRQMIVLGGEIRSGALPLTEGSCSDDFEPVRVLDLSTYEWQWELPDSKDSYQVPPIIYQKIGGGPSGGATVTAPKRGFADATLSSLLQLRVPTTGAGGSTSRHPSTGWGADSSGKSPGAGAIAGAVAGGVGGLAAVAGLTWFLMRNKRRKRSEGEEEDGSVLKEEAEVEERRAIPEMESVDMASPGGSLVSPLSTMASPKPSEVDGREVYELPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LN46</accession>
    <name>A0A367LN46_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_2019</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat cdt2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LN46"/>
    <dbReference type="STRING" id="1330021.A0A367LN46"/>
    <dbReference type="OrthoDB" id="2096344at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051865">
        <property type="entry name" value="WD-repeat_CDT2_adapter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22852:SF0">
        <property type="entry name" value="DENTICLELESS PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22852">
        <property type="entry name" value="LETHAL 2 DENTICLELESS PROTEIN RETINOIC ACID-REGULATED NUCLEAR MATRIX-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="375"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="679"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="641"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="130"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="642"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI15866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="746" mass="81273" checksum="9A2F645A4C32723F" modified="2018-11-07" version="1">MEANIILSDHDDMPSSPPAVQLDGNDFFSPTTVTRSSRSSTRLPSRSPTRSMTRTKERRVPSVTPRRLRNFFTPRNQLSTSSRMTLGTMDSASVNRLARVPLSPPPSSDPIEPPSSPTERIQAVEDNPWKRRHPHQSGLRTKRRRTEDEPQSTRASANNAVDERAALTKRRTLVSDGRHPGLWPPYSQQQSQFFKASRGGVTGLMSKPLESSPPLITDLPTPLRGYQPQPVRKLRNRGFEACLLDREHGFSTHTGKRYLAFPASDPRAEMADFYSESSDAYYCNPVGDQPGASIPFSLASCHRTSLTAIGDERGDVRFLSTADDDRNRVTSWVKVHDNAIMDLDISADDARMASACGDRSGRVLDMHTQTIAVELGGHRDSLRQVTFQPGGGGGNVLASSDRAGRVQIWDLRCSSLPAQCFSSAEDGTGRDRRLDPVTARTVNAIDNAHERTVEGSTSSSSVTALQWLPAGREHLLLTGSEANASIKLWDTRYIKPRRQRQAAETPLAATPQPASHAWRSYGITSMALGADAARLYVVCKDSTVYAYSTNHLLLGHAPELLDGASKRKPLGTQGLGPLYGFKNDMLRVGSFYVKCAIRPAGGGGGGGGGELLAVGSSDGCAVLFPTDERYMRAVWARREHVPPTGTTTPAPLLSTPSSSSSPSSSSSMSTILNAGTPLVRGHTHEVTTLTWSQEGKLLTASDDCLVRQWRQKASRASYLRQVGEFGGERHLAGWAEVGDDWDDDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNA0</accession>
    <name>A0A367LNA0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_3228</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNA0"/>
    <dbReference type="OrthoDB" id="10316763at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI15914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="154" mass="18219" checksum="DF7A400EE2A89B26" modified="2018-11-07" version="1">MMMLEIRKEEKMVTTMMIMMLLLMMTLMLNDMDVMFRRRRRRRQMADKAQRQGKAKERVPGGSLRERQEWSWSGMLSAQCTRGAPEDIAEQRNEVWGRVPTGVRHARCRSTPADRETCGGACERESPRDKVVWPSGRMEWTGGREKLHRDYRWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNV2</accession>
    <name>A0A367LNV2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA repair protein RAD14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_3218</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNV2"/>
    <dbReference type="STRING" id="1330021.A0A367LNV2"/>
    <dbReference type="OrthoDB" id="5368863at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000715">
        <property type="term" value="P:nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21077">
        <property type="entry name" value="DBD_Rad14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.530.10:FF:000003">
        <property type="entry name" value="Dna repair rad14 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.530.10">
        <property type="entry name" value="XPA C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000465">
        <property type="entry name" value="XPA/RAD14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022656">
        <property type="entry name" value="XPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022658">
        <property type="entry name" value="XPA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037129">
        <property type="entry name" value="XPA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00598">
        <property type="entry name" value="rad14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05181">
        <property type="entry name" value="XPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00753">
        <property type="entry name" value="XPA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="XPA C-terminal" evidence="12">
        <location>
            <begin position="227"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="8"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI16116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="382" mass="43237" checksum="F13E133FD2E2604E" modified="2018-11-07" version="1">MERPQTPPNNTAAQQNSVTSASPLTPEALRRIEENKLRAKAIRQQREAEQSASGVLPSPIRTSTGIVPTANVHVSKPVNGKRPLSSISTGTKRDGRNKGGAEDPGALRPAPKFAKFVDYNMSSMTDTKGGFLSVEDDPHNYALGGQKPGQAEQRPGNMTVQEWERQQLMRKLRRQKTGPFEPGLSVLNDEANRKRCRECRSLEIDFVWEEVFHICICHRCKEQYPEKYSLLTKTECKQDYLLTDPELRDADLLPHLSKPNPHKTHWHDMNLFLRFQVEEYAIKTKWGSAEALDAEYERREGQKKARKEAKFKDKLIELKRKTRTDAFRRQAGTLGKTGASKFGDAIGGQRHVHEWGRTVANAEGMTVKTCNECGMEVEELEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPB2</accession>
    <name>A0A367LPB2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ornithine carbamoyltransferase, mitochondrial</fullName>
            <ecNumber evidence="8">2.1.3.3</ecNumber>
            <ecNumber evidence="9">6.3.3.1</ecNumber>
            <ecNumber evidence="10">6.3.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25">Ornithine transcarbamylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="ORF">L249_1851</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="31 32" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31 32">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="23">Catalyzes the second and fifth step in the 'de novo' purine biosynthesis pathway; contains phosphoribosylamine--glycine ligase (GARS) and phosphoribosylformylglycinamidine cyclo-ligase (AIRS) activities.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23032"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:137981"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.3.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>5-phospho-beta-D-ribosylamine + glycine + ATP = N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17453"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:58681"/>
            <dbReference type="ChEBI" id="CHEBI:143788"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>carbamoyl phosphate + L-ornithine = L-citrulline + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57743"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="EC" id="2.1.3.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="24">In the C-terminal section; belongs to the AIR synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the GARS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="31">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.3.3" evidence="8"/>
    <dbReference type="EC" id="6.3.3.1" evidence="9"/>
    <dbReference type="EC" id="6.3.4.13" evidence="10"/>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1330021.A0A367LPB2"/>
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        <property type="reaction ID" value="UER00125"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:amino acid binding"/>
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        <property type="project" value="InterPro"/>
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        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="term" value="F:metal ion binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:ornithine carbamoyltransferase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:phosphoribosylamine-glycine ligase activity"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="F:phosphoribosylformylglycinamidine cyclo-ligase activity"/>
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        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
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        <property type="project" value="UniProtKB-UniPathway"/>
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        <property type="term" value="P:adenine biosynthetic process"/>
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        <property type="term" value="P:L-arginine biosynthetic process"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Asp/Orn_carbamoyltranf_P-bd"/>
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        <property type="entry name" value="Asp/Orn_carbamoylTrfase"/>
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        <property type="entry name" value="Asp/Orn_carbamoylTrfase_sf"/>
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        <property type="entry name" value="Asp_carbamoyltransf_Asp/Orn-bd"/>
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        <property type="entry name" value="Orn/put_carbamltrans"/>
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        <property type="entry name" value="PreATP-grasp_dom_sf"/>
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        <property type="entry name" value="PRibGlycinamid_synth_ATP-grasp"/>
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        <property type="entry name" value="PRibGlycinamide_synth"/>
    </dbReference>
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        <property type="entry name" value="PRibGlycinamide_synth_C-dom"/>
    </dbReference>
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        <property type="entry name" value="PRibGlycinamide_synth_C_sf"/>
    </dbReference>
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        <property type="entry name" value="PRibGlycinamide_synth_CS"/>
    </dbReference>
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        <property type="entry name" value="PRibGlycinamide_synth_N"/>
    </dbReference>
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        <property type="entry name" value="PurM-like_C_dom"/>
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        <property type="entry name" value="PurM-like_C_sf"/>
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        <property type="entry name" value="PurM-like_N"/>
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        <property type="entry name" value="PurM-like_N_sf"/>
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        <property type="entry name" value="PurM_cligase"/>
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    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00658">
        <property type="entry name" value="orni_carb_tr"/>
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        <property type="entry name" value="purD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="purM"/>
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    </dbReference>
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        <property type="entry name" value="TRIFUNCTIONAL PURINE BIOSYNTHETIC PROTEIN ADENOSINE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10520">
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    </dbReference>
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        <property type="entry name" value="OTCace_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AOTCASE"/>
    </dbReference>
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        <property type="entry name" value="OTCASE"/>
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    </dbReference>
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        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="PreATP-grasp domain"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00097">
        <property type="entry name" value="CARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00184">
        <property type="entry name" value="GARS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="19 29" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0436">Ligase</keyword>
    <keyword evidence="20" id="KW-0460">Magnesium</keyword>
    <keyword evidence="21" id="KW-0464">Manganese</keyword>
    <keyword evidence="16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="17 29" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-grasp" evidence="30">
        <location>
            <begin position="114"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00007805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00011233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00013047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00013255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00021536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00029388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00029444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00033269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00047843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00048772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00049057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EMBL" id="RCI16285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1245" mass="131884" checksum="F742B5C28CAF3F6F" modified="2018-11-07" version="1">MTPPLRILLIGSGGREDALAWKLSQSPSVEAIYAIPGNGGTATCPKTTNITSVSADNFPALVEFAQANGVNLVIPGPEAPLVNGIEAFFQDAMIPFFGPSKEAAQLEGSKTYSKNFMKRHGIPTAAYENFTDFAAATAYVDQTAHGLVIKASGLAAGKGVILPQSKEEAKDALRRIMVDKEFGDAGDEVVIEELLIGQELSVLTFSDGSTRRSLPLAQDHKRALDGDLGPNTGGMGCYAPTNIATDDLVRTIDSEILEPTFDGLRRDERPFRGILFTGIMVTAAGPKVLEYNVRFGDPETQTVLPLLSDDTDLAQIILACCQVRLHKCRLEINKLFSATVVLAAGGYPGAYAKGTPINVSDPPSGVTIFHAGTKLEGNQLTVAGGRVIAVNAVADSLDAAVKLCYSALDSGVVKFDGMFFRRDIAHRAFGREVAAKAMTYAAAGVDIQAGNEFVQIIKTAVASTKRPGADAEIGGFGGELDLSRCGCDFKEPPVIVAAIDGVGTKLMVAQALRQHGSVGIDLVAMNVNDLIVQGATPLMFLDYYGCSKLDKASAASFVQGVADGCRQAGCALVGGETAEMPGMYRGEDYDAAGCAIGAVTSAGRLPRKDALIAGDVLLGLASSGVHSNGYSLVRRIVDRAGLDWAAPAPWDPSETVGRSLLTPTRIYVKSLLPVLPRVKGLAHVTGGGLVENVPRMLRDDLAAEIDFGSWPVPFIFRWLKDVGGVAPAEMVRTFNLGIGMVIAVGAGEAEAVACALVAESVFRIGRIIPRQQQDQHCVVRHLDTMAPYYFRMGIGLRPPEPCMCCRCGEAPPSAGTTCPGACLAPHVHWDRLSQGILYPLGHFAPGGLDVALTRRDNLSQRGTHPEADHVIPTHHLGACPAWGAIKIGNLLVTDLTSALRGLANSVSKRSYSQSQATAPRHLMSISDLTANELASLVRNAASRKKAVKAGQTPPSLASSLSGKAVAMMFSKRSTRTRVSTEAAVSIMGGHAMFLGKDDIQLGVNESLYDTSVVISSMTSCMVARVGPHSDVVDLAKNSSVPVINALSDDFHPLQTVADLLTLHETFPNSSSSAGLGLGLAGLKLAWIGDSNNVLFDLATGCVKLGIDIAVASPKGYSIPDPMKQLILAAADGVKSPGKLTETTRPDEAVKNSDVLVTDTWVSMGQESEMKKRLDAFAGYQITNELARRGGAKDSWKFMHCLPRHQEEVADEVFYSPRSLVFPEAENRLWAAVSVLEGFVVNKGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPI3</accession>
    <name>A0A367LPI3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GPR1/FUN34/YaaH-class plasma membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_3200</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPI3"/>
    <dbReference type="STRING" id="1330021.A0A367LPI3"/>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF4">
        <property type="entry name" value="PROTEIN ALCS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI16320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="34753" checksum="EEE2DE31A0FBF11C" modified="2018-11-07" version="1">MDGGAMLDRSQAPAPSRSLDAILPTRTGMPGKLRTNDLAQGGNCSTMSDKTHPSPTPRPDGEDGRLEALQNLRTATSVSMSPELFEKLYLTPANNKGGNLRRTFGNGAPLGLAGFIICLSPLSADLMGWRGAGGHGNASLGSFWFQGGILMIIGCVLEWVLGNTFPAVTFGVYGTFWMGFAATQTPAFAIGSAYAPGKSAIEGMETRGYHASNAWWLLFMAIMSLLFCVCALRTNVVLTSLFFCIMVQFTLQTGASLALANDFETNKLVAKHLGVSAGAFSFIASIAGWYLLTAELLAAVDFPYQLNVGHLGNVLKGKSHNQPGKEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPN6</accession>
    <name>A0A367LPN6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPN6"/>
    <dbReference type="OrthoDB" id="2446291at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="291" mass="32188" checksum="FF07343AEE13311F" modified="2018-11-07" version="1">MFATQQSRDAMQDTGRKRLRDDDELVLGEHRKKRLQSLPFRSSPKLTQQASTSCREAVPRSHLSSLPPSAAMDLEMADDVPVSSSLPYRVEQSLSEMDVCDRDAIGRMPTPIQPSFAAQVRGQHCEWAGPGPALKTPHGIVNMGHHQTGFSSDVYVPRALASAPLDWHSFHNNRRLPSPISENGDASSMMVDDADDEDDGRQDCLPPPLVRCSSADAMHHPNAPMCLDPCHDSGPMSPSPGRSRGHVRSKHTVNSWTWQPGMKKSFSIGYRPDCEKCRLKVPGHFNHIIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQY1</accession>
    <name>A0A367LQY1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein N-terminal and lysine N-methyltransferase EFM7</fullName>
            <ecNumber evidence="8">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Elongation factor methyltransferase 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">EFM7</name>
        <name evidence="12" type="ORF">L249_2709</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">S-adenosyl-L-methionine-dependent protein methyltransferase that trimethylates the N-terminal glycine 'Gly-2' of elongation factor 1-alpha, before also catalyzing the mono- and dimethylation of 'Lys-3'.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQY1"/>
    <dbReference type="STRING" id="1330021.A0A367LQY1"/>
    <dbReference type="OrthoDB" id="5600085at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071885">
        <property type="term" value="F:N-terminal protein N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.430.10:FF:000001">
        <property type="entry name" value="Copper fist DNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.430.10">
        <property type="entry name" value="Copper fist DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03223">
        <property type="entry name" value="Methyltr_EFM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051763">
        <property type="entry name" value="Copper_Homeo_Regul"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001083">
        <property type="entry name" value="Cu_fist_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036395">
        <property type="entry name" value="Cu_fist_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025784">
        <property type="entry name" value="EFM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088:SF9">
        <property type="entry name" value="TRANSCRIPTION FACTOR GRISEA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G13190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28088">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR HAA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00649">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00617">
        <property type="entry name" value="COPPERFIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM01090">
        <property type="entry name" value="Copper-fist"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00412">
        <property type="entry name" value="Cu_FIST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57879">
        <property type="entry name" value="Zinc domain conserved in yeast copper-regulated transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01119">
        <property type="entry name" value="COPPER_FIST_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50073">
        <property type="entry name" value="COPPER_FIST_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51560">
        <property type="entry name" value="SAM_MT_NNT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Copper-fist" evidence="11">
        <location>
            <begin position="91"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="157"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="279"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="463"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="545"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="763"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="834"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="281"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="305"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="552"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="763"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="1004"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="1030"/>
            <end position="1032"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="1052"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="1084"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="1108"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI16828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1224" mass="133036" checksum="3A0894DDC70B468F" modified="2018-11-07" version="1">MALCASLIFSSSLPQSTHVRGFEGRFSPPSFCNRISVFDWNFFFPFSPFLCRHLTLTSEPDSATTFQINRYGRLVSHRRRRLVFPLKPPAMPLINGQKMACEPCIRGHRSTKCTHANERLMVPVRKPGRPLSSCPHPSSRACSCAAVTAAIPRKQKCRCGTSDGSDDGDAVSTSSPSKSAAFRVHKQGPPKPVPVDVAGLERMDAGQVNISYRPAPVPVYRGLSLTPTDKSSFSSTEEPALPMFPYPVQPSTSTNGCSPTPQNNGGGCCGAATNGHPPVVNGSSADMRSKATPDSSENAPPPVLPGVVQQQQQQQQHPPSGQVLAPFQAIYPYLSQPTIFNYPPQFGSFLQPLQPEQWKQFMAAMNLAHPAVTPFSFDMPATGSFGGGGTAPSNGASWTSHRCTCGDTCQCVGCAAHPYNEATQDYVRSAWNTMVEEGQKSRVDGDGAANAVDGGITPNGCCGPQNTTEAATGRADGALSPAAPQTPSDGTSGLGEEQTLSANDFFFVSYPFGDTCAGDTASCPCGDDCQCIGCAIHNAPLPPPTDADERAAPPTSSSLASTSDFAPPNANANIFEHSKAAPRRKGLKEYTGDRQRGCLSCRRGKTDALDGVSLDPMRGSTPKTAPIGQRANLNLKVGLRHGRGGEARLPRQRHHDRDQAAGANVQLPFSARPLVKADLQAFGSLFAYYLGVQKCKDAYEMGERELRGRWKSFVRRWNSNKLAEGWYDPDTFARIVKLEEEGWDLTLRDELIRESQEAERSALRAARKADRKEQKERLEEIAPRAEAGTHERKMEKRRETNDKMRQFRDKSPGMEAANDKDIMGGGESVEEYRQMKARERRRKSERQIRREQLERAQKEMTEAKRRAWQLREEGTINMLRELARQRFGGGASGSGSGIGDDDRGSVCCGAGRPMHSLRVAVPADSFSFLSHPAALLPPLLGTDRDPSLAGPMDGDYSTGSLLSEPEDFYPPTPPPTTQTYTMHSGRTLELHLVGHSPTEAHHLWNGAKLAADFFERAPETVRGRTVLELGAGAGLPSLVAAVLGAKKVVVSDFPDPELVANMQKNIDACEDGVVDVVDAVGFVWGADSSPLMARLGSPSAKFDVVILADLLFRHSEHAALVKTIGETLRPAKDCCAYVFFTSYRPWKQHLDMAFFDVARAAGFEVEQVAERKLDRPLFDDDPGDVEVQKTVKGFVVRWPAAIGEFCLLTLTCFPARGLEDTKYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LR38</accession>
    <name>A0A367LR38_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LR38"/>
    <dbReference type="OrthoDB" id="5151921at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="736"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="767"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="882"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="933"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1083"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1190"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1415"/>
            <end position="1523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1538"/>
            <end position="1697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1741"/>
            <end position="1767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1805"/>
            <end position="1826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="463"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="588"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="787"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="811"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="899"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="984"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1201"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1288"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1448"/>
            <end position="1459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1475"/>
            <end position="1489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1538"/>
            <end position="1547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1569"/>
            <end position="1585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1618"/>
            <end position="1629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1639"/>
            <end position="1658"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1664"/>
            <end position="1693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1744"/>
            <end position="1753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1754"/>
            <end position="1767"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1826" mass="196003" checksum="74C1DACBAF913040" modified="2018-11-07" version="1" fragment="single">VACSSFFRRPFHRRLQIPISISAEPVGITGSHAMAGPVDRDSGLLQTSAAAVSPYQLNVNRTKTRKWVEAKTQSYDGDDWGAADYEPQGGFQHEPVPSLPTGRYPLPAHHVTSARPERPSAELMPPSIQVPTDRHKLPSSESFRSVSSPVSSHSTRAADVSPTDAYSPDEKLQRRSTIDPLPDTDEDPFQPAVSVGSDKPFAKSKVDRSDEDKCPPRDSGTDVASLGERHARRDSVSPQLPDVARMSSFGPDFFDVTPKEPAIASLAHDAVAISTASPTEPKPAGNLLPADAGEASSLPTRLLPLQQPEPSTMNDSVEETPKVGNAIEEDEDRDIVSLTPASDNLGRPDVPEPPVISCIDSQVDATAAQELAHIQARSPLLQPDPDWPSIPPLKTPSPRPSEGTLDKSQEASRSSSTGEHNNQPASAERYPKPGPVQRKPTSSTITPSSVKDSDALSEEILRSLSPSASSSALTTSADDHHAMQPTSPVMMRDSTYTLGDYDDYWEEKTTSLPPARPSKVPLDTPDAPADGTELRRRFSWEVDDAEAVALPHVSSSSAAREPMEAEARRQLTPTPSSDGGGGDDDDVAAVTRDVASDGWAQPAAPDPPSPLSVASDTRTSVVGRDSKRPSLVDDKAVAQVVSNLSSPTPPPEPPVTLSSSPPAEAVRPKSPGLPAQTRVMAFREVMGMPNVSDRIAKFNETRDHVAMTDSGLDAWLASVQAQYPEYAQEAAGLCQPAYSSPSSASSQPTVQHQQQQPYYQQYLNASAPNASHSGRSRLAGLPIPSQVAGSSFGHPSNQIGTKSKELMHSAGKMGKGLLSKGKSKLRGSGDKFAPQGEGSGPRTERRTSWAALSLGRSRPDETVAHATVEGAAAWRADAFQGYRGFEGSDQQPPVRQRHVSTEPDAPRPDEQEVAAKVENTAADQVPEGWVLVASPESEVEPCSPAEEVGREAPKRISSFVGLPPIRRSSTFGLTNRSKRTRRRNSLDHDDDKGDYADSHDGQPAEPLSLVPSPVMEVPNPMDRDKDDAGADVFNFEQDENKETEPPTRVFHPMIPPNTSADPPKSPIPSLLTGDWKLEESHLSEPLHCKTRRHRPGTGNSQQQAYREYDKETGMPLLSVPSPAVAPYATPPSSAHRYPGLFPVPPGEDGGHRPPPPRSQTWGQPEQRVYHAARPRAETAFDVVHRGEFGAGRHRGRSQLRADAVAEGAAAVSGHGREPRKRQSGFFSSLAGRISTSRDRGSLSMVPGSPRRPPSSSSLFNDQASAAAGQHETRKKKKRFSNIAALSNLKDKLHSTGHEQDTRSPAAHNPLHGLERSSTTSSFDLAPPQAIGEDGVERRRRRRSSVTDMISGMLGRRPGSRSGEPAAMAGQGEPQLDPKPASGVVGHHPGCRPHASAVQPGMKAAATVPTVTVRPVAQRQPRPSPLGIDAPVTNRNLGAEAGCPRRQRVCVEEKPSRSKDGGLALAGIGTAHEGQTDVSPDTSVVSDVQSEALSVMKRRPLRSVSSDEASDHGKSALSLTSQQTDSRWKLLKNRIYAQAASASTSNQNRGGVGGGGDRLSGPKVPGSTRKTSEQMERETGAMHPSKEASSSPWVISESRYERVPLPRSHGMVQGVTAQSEDRSAGARDGRGSPAVCGGRGYDEERVAMEARSGRRHEQQDGGSPRSRQSPQQATRQEGMSPSTAGVSSPESQRSPAKADIVSPMLFCLPSPPLSKAKEGLVSPSGVRAVDYQVSMASLATRFEAEQEAPGEEDEHERQQAKEGEKAAELDDTAERYMRSRRLEAQEEKIACRVEDVEDVVPQMSATSYPGQEWSPYGALGYEDWRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRB7</accession>
    <name>A0A367LRB7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Serine/threonine-protein kinase TOR</fullName>
            <ecNumber evidence="17">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">L249_2535</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Associates with DNA double-strand breaks.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Vacuole membrane</location>
            <topology evidence="14">Peripheral membrane protein</topology>
            <orientation evidence="14">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the PI3/PI4-kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="17"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LRB7"/>
    <dbReference type="OrthoDB" id="381190at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016242">
        <property type="term" value="P:negative regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901992">
        <property type="term" value="P:positive regulation of mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031137">
        <property type="term" value="P:regulation of conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905356">
        <property type="term" value="P:regulation of snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05169">
        <property type="entry name" value="PIKKc_TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000020">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.150:FF:000001">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000371">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000446">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000487">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000582">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000004">
        <property type="entry name" value="Serine/threonine-protein kinase TOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.150">
        <property type="entry name" value="FKBP12-rapamycin binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009076">
        <property type="entry name" value="FRB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036738">
        <property type="entry name" value="FRB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024585">
        <property type="entry name" value="mTOR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026683">
        <property type="entry name" value="TOR_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057978">
        <property type="entry name" value="TPR_DAAF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF9">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08771">
        <property type="entry name" value="FRB_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11865">
        <property type="entry name" value="mTOR_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25757">
        <property type="entry name" value="TPR_DNAAF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01346">
        <property type="entry name" value="DUF3385"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01345">
        <property type="entry name" value="Rapamycin_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47212">
        <property type="entry name" value="FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="9 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0469">Meiosis</keyword>
    <keyword evidence="8 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 17" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0926">Vacuole</keyword>
    <feature type="domain" description="FAT" evidence="19">
        <location>
            <begin position="1244"/>
            <end position="1855"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="18">
        <location>
            <begin position="2030"/>
            <end position="2346"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="20">
        <location>
            <begin position="2406"/>
            <end position="2438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU364109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RCI16993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="2438" mass="275186" checksum="D69C9F093483B4FB" modified="2018-11-07" version="1">MAQQQQVALERLEHITRGLRSRIGDDIRKRAALQLRDLVVVCHRDLSQEQFLAFYNVVNNRITQLITHGSDSAERLGGIFALDALVDFEGVDVAAKYTRFTQNLKTILRGKDINPMQPAAIALGKLCRPGGSLISELVESEVNTALEWLQNDRVEERRYSAVLVLRELAKNAPTLMYQFIPTIFDWIWVGLRDPRKLIRATSAETVSACFRIIRERDQEMRQLWMSKIFNEARLGLKINTVESIHASLLVLKELLEQGGMFMQEHYQEACDVVFKHKDHRDPTIRSTVVLLIPDLASYSPADFAHGWLHKFMVYLSGMLKKDKERNDAFLAIGNIANSVKSAIAPYLDGVLIYVREGLSVQSRKRGSVDPVFDCISRLAVAVGQTLSKYMEALLDPIFACDLTPKLTQALVDMAFYIPPVKPTIQERLLDMLSVVLCGEPFKPLGAPQPNTLSSVPAIAKDAKDPQAYEHRRAEVKLALNTLGSFDFSGHILNEFVRDVAIKYVEDEDPEIREAAALTCCQLYVRDPIVNQTSYHALQVVGDVIEKLLTVGVSDPEPSIRRTVLAALDERFDRHLAKAENIRILFFALNDEVFPIREVAISIIGRLAKFNPAYVIPSLRKTLIQMLTELEFSDVARNKEESAKLLSLLVQNAQTLIKPYVEPMISVLLPKASDPLPSVAATILKAIGELATVGGEDMLPYKDRLMPLIIDALQDQSSNMKREAALNALGHLASNSGYVIEPYLEYPQLLEILQGIIRTEGQRGPLRQETIKLMGILGALDPYKHQQVEERIPEVQRRVESNQMTDISLMMTGLTPSNKEYFPTVVINALLQILKDHSLAQHHAAVIEAIMNIFRTLGLECVPFLDRIVPAFLHVIRSSASTRLESYFNQLATLVSIVRQHIRNYLHDIIEILQEYWHKSTSLQTTIISLVEAISRSLEGEFKIYLAGILPLMLGVLDKDLSAKRIPSERVLHAFLVFGASAEEYMHLIIPVIVRTFEKQGQPAFIRKQAIDTIGKISRQVNLNDYAAKIIHPLTRVLDMGEPPLRAAALDTLCALIQQLGKDYLHFMGTVNKVMSLHQIQHQNYELLASKLKKGEVLPQDLSSQPRFTDMADETPLADLGTKKLEMNPVHLKAAWDTRGKSTKEDWQEWLRRFSTTLLTESPNHALRACASLASVYLPLARELFNSAFVSCWSELYDQFQDELIQNIESAIKSENVPPDLLGLLLNLAEFMEHDDKALPIDIRVLGREAARCHAYAKALHYKELEFLQDQSSGAVEALIVINNQLQQSDAAIGILRKAQLYKEGIQLRETWFEKLERWEEALAFYNKREREMAADQPVPIEIVMGKMRCLHALGEWDALANLTGSTWANSAPEVQRMIAPLATAAAWGQCKWDSMDNYLSSLKRLSPDRSFFGAILALHRNQFREAIACVEQAREGLDTELSALVSESYNRAYQVVVRVQMLAELEELIVYKQCDEKKQATMRKTWETRLQGCQRNVEVWHRMLRLRALVLSPVENMRMWIKFANLCRKSGRMGLAEKSLKQLIGSDAALETMIPYWPESINERTTAAAAAARNIPGAGDLRRAQPPTARRDGVAERTLYCLQRFTNDTAHRLDVAKAHLSAQAGSDMNLTADYGFQHQVDPALVSPQTQRALYDQTVLLAKCYLRQGEWLKALNKDDWQCSKVQEILTSYSQATKYNPRWYKAWHAWALANFEIVQTMSSSTASSSSSSAATHNDGAGPPLSRADQAMVIEHVVPAIHGFFKSIALSAGSSLQDTLRLLTLWFTHGGSSEVNAAVMDGMANVSIDTWLEVIPQLIARINQPNKRVQQSVHNLLADVGRTHPQALVYPLTVAMKSWQNTRRSRSAAQIMDSMRQHSANLVAQADTVSHELIRVAVLWHELWHEGLEEASRLYFGDHNIEGMFATLEPLHELLERGPETLREISFAQAFGRDLKEAQEWCHQYETTKNVNELNQAWDLYYQVFRRISRQLPQVTSLELTYCSPKLLAAKDLDLAVPGTYKSGQPIVRITSFDSTFSVINSKQRPRKLNANGSDGVSYAFLLKGHEDIRQDERVMQLFGLCNTLLANDSECYKRHLNIQRYPAIPLSQNSGLLGWVPNSDTLHVLIREYRESRKILLNIEHRIMLQMAPDYDNLTLMQKVEVFGYALDNTTGQDLYRVLWLKSKSSEAWLERRTNYTRSLGVMSMVGYILGLGDRHPSNLMLDRITGKIIHIDFGDCFEVAMKREKYPERVPFRLTRMLTYAMEVSNIEGSFRITCEHVMRVLRENKESVMAVLEAFIHDPLLTWRLTSAASPAGPNFQSEREAALVGPTAARARRHSILDADVAPSELMANGQPSGPPRTRARTNSSAVAEAVNGAAQETESQNARAVEVLDRVSQKLTGRDFNTPDELDVINQVNKLIVEATKLENLCQHYIGWCSFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRK2</accession>
    <name>A0A367LRK2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_3077</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRK2"/>
    <dbReference type="STRING" id="1330021.A0A367LRK2"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000117">
        <property type="entry name" value="MFS hexose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF66">
        <property type="entry name" value="MFS HEXOSE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="354"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="397"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="439"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="468"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="38"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="514"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="527"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI16980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="541" mass="59739" checksum="A43986176A01FDBF" modified="2018-11-07" version="1">MASVHNDNEEQKESSTDAPRLEPVTWYREPHLRKLYFSCFFLLIGSATTGFDGMLQNTSQQMDAWKAFFPEYLDAHKLGVLINIYNIGSITSFFASPYMADVLGRKPTIIVGCVIMIAGACVTSLSNGYSMYLGGRYVVGFGNSLVQVCSPMLLTELCHPQHRGPLTTVYNCLWNLGALLVSVIGWGTASVGNDWSWRSITLLQALPSIVQLIGIWWLSESPRFLVSKGRSRQALAVLAKHHGGGDANHPTVRFEFREIKEAVEMERKADKTSTYLDFFRTKGNRWRLAIVVSLGIISQYSGNALFSNYIDVVYEGAGIREQNKKLALTAGRTMMDLFVSITAALSVDKVGRRPLFLVAISGMVVAFGCWTVVGAVYENSAVQTPGGGGDGVSYTNQAAGFAQIAFVWLFAIFYDIGFSGLLVAYALEVLPFHLRAKGMVVMNIVVQAVLAIGNQTNKLAWNSLPRHWNFMLFYTLWNTCELVFVYFFYVETKGHTLEDIARIFDGEDDAAPAVDDAEQANKETRLSSNHSSSNSPGVLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRX6</accession>
    <name>A0A367LRX6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SART-1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_2384</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNU66/SART1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRX6"/>
    <dbReference type="STRING" id="1330021.A0A367LRX6"/>
    <dbReference type="OrthoDB" id="5583at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000481">
        <property type="term" value="P:maturation of 5S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045347">
        <property type="entry name" value="HIND"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005011">
        <property type="entry name" value="SNU66/SART1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14152">
        <property type="entry name" value="SQUAMOUS CELL CARCINOMA ANTIGEN RECOGNISED BY CYTOTOXIC T LYMPHOCYTES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14152:SF5">
        <property type="entry name" value="U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19252">
        <property type="entry name" value="HIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03343">
        <property type="entry name" value="SART-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="274"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="581"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="57"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="275"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="365"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="421"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="473"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="584"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="597"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI17205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="645" mass="72043" checksum="4BEA47CDF5485F4C" modified="2018-11-07" version="1">MDAATIQETNRIRLSLGMKPLPVPGAEPSTTPKAASDSHGDAASTLESRQAQAYDNYKTHMDADRNKQRREAKAAAIRKARDAAQRFAILEGQGLGEMDQGGDLDAKTWLMGQKKRQKKIAKARKLEEEMAAAEAEAAASVKYSSKDLAGIKVTHDSSAFIDGNEQILTLKDATIEENEEEGDELENINIREHEKLTDKLDLKKKRPVYNPLDDDNEDGQRGILSQYDDEILGKRTKQFTLDANGTVAELADILDQPARKANEALNVSLDDIIKVKKPSKKSKNTRKKLADEDDVLFQPQTGENGSAMEVDGEQSSKKKRKAETESVVDDDELQSSLATQRNKALKKRKISRPEDIAKQVRAQADDEPEPGADDGEEGLIIGETSEFVANLRKHDDDDDDEQQQRAKKQGQVAANASWPQPDEDEAMADADDKDDGDDDDAQANGNGAAADDDGTFDDEKTVGGSLSATLALLRERGLIEDSRGDSTHRSQRERREFLQRKRQLEEEVDERARLQRERDRASGKLDRMSRADREDYARQQNAWRDQQHSRRMADLISSTYKPTVELKYTDEHGRQLDRKEAFKHLSHQFHGKGSGKGKTEKKLKQVEEEKRREAQSLFDASQGGGMRAATSQQLKKRKEAGVRLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LS17</accession>
    <name>A0A367LS17_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_2143</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LS17"/>
    <dbReference type="STRING" id="1330021.A0A367LS17"/>
    <dbReference type="OrthoDB" id="27140at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000038">
        <property type="entry name" value="TBC1 domain family member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000031">
        <property type="entry name" value="TBC1 domain family member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF337">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="98"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="386"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="557"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="393"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="565"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="592"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="614"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI17246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="693" mass="76812" checksum="754096A0DB51F5EE" modified="2018-11-07" version="1">MRSLEETLSRWKTTVECGESLADLQKAVKNNGSASPFAPRCLAVDHLLVALICKMFLLSTRAGLAQALEEGRRDYEQRRNHFLNFIEHPEALAQLAVDPLTDDPESPWNTVRQDETMRKEIQQDVQRLPDEANYHQDHVQALIINILFVYCKVNPSRGGYRQGMHELLAPIVHVVELDAVDRVAAEADGSSLDASMLVVIDSSYIEHDAYMLFSRLMEHALVFYELRDVSTPSKSCDGAPEQRSTIVDKSRFIHEVCLRSVDDELATHLVDMEVLPQIFLIRWVRLLFSREFPLDQVLFLWDIIFAVDPCLQLIDFICCAMLLRIRWQLLEADYAVCLQLVLKYPQPEPPHGPHTLVDDAIYLEAHADASGGGALIKKYSGRMPDALSPCQRAAQTRTPGRQTSASPRRRTYGGRSPLTSPPRFLQHPGGVESLFQGAAKSAKGVLERGEKLGLNSAVRDAVGEIRRNVQMFNETRQTSKSPRSSHEDEGAAGALAAMERRNKQLAGLLEETVASLKSISLSSLEDKSKSLDAIELAAAKVQFVQFYLGDSSMEMAPADEPEVAEEAKSEEGSVDVAKRADDDVDDDAVKAETTQSNGQDSSSEPSRPAAPMPTRSTLAQSSFSWMLEPDLPSRRPQAASGSKHGTTQHRKRPSSNASRDRNAFLFGEGTMERQSSGDEIFGLEPMGKAKDKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LS64</accession>
    <name>A0A367LS64_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_3311</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LS64"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI17251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="82" mass="9442" checksum="867EA6ABAB19C7C5" modified="2018-11-07" version="1">MRASDYIQLSQKGQEPIDQKGLYWLPLLGSSNRRAYLADGRMAFTGTRKAVLKTSSFALRLSFKLLPKARSPTCSNRWYKYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LSI3</accession>
    <name>A0A367LSI3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">RuvB-like helicase</fullName>
            <ecNumber evidence="15">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L249_2381</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the RuvB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="15"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LSI3"/>
    <dbReference type="STRING" id="1330021.A0A367LSI3"/>
    <dbReference type="OrthoDB" id="10060499at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002221">
        <property type="entry name" value="RuvB-like 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000010">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000002">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00830">
        <property type="entry name" value="ENDOLAPTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 15" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="68"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCI17202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="471" mass="51303" checksum="49880AFF3E814D86" modified="2018-11-07" version="1">MAAPLVTVSETKDLRGLNLIAAHSHIRGLGVDGTSLEPRASSQGLVGQQKARKAAAVILQMIKDGKIAGRAVLIAGPPSTGKTAIAMGMAQSLGPDVPFTSLASSEIFSLEMSKTEALTQAFRKSIGVRIKEESEMMEGEVVEIQIDRSVTGSAKQGKLTIKTTDMEAVYDMGSKMIDAMTKERVMAGDIVSIDKSSGKITKLGRSYARSRDYDAMGADTKFLQCPDGELQKRKEVVHTVTLHEIDVINSRTQGFLALFSGDTGEIRSEIRDQINTKVGEWKEEGKAEIVPGVLFIDEVHMLDMECFSYINRALEDELAPVVIMASNRGNARIRGTDYRSPHGLPLDFLDRVVIINTHAYSSDEMRQILSIRAQEEEVDLSADALALVTKIGQEAGLRYASNLISTSQLVCAKRKAKQISIDDVQRSFHLFYDPGRSVKFVTESEKRLIGNDGKVDLSATNGSGGEKMDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LSM8</accession>
    <name>A0A367LSM8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mannosyl-oligosaccharide glucosidase</fullName>
            <ecNumber evidence="1">3.2.1.106</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Glucosidase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_2420</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>N(4)-(alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + H2O = N(4)-(alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-beta-D-GlcNAc)-L-asparaginyl-[protein] + beta-D-glucose</text>
            <dbReference type="Rhea" id="RHEA:55988"/>
            <dbReference type="Rhea" id="RHEA-COMP:12806"/>
            <dbReference type="Rhea" id="RHEA-COMP:14355"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15903"/>
            <dbReference type="ChEBI" id="CHEBI:59082"/>
            <dbReference type="ChEBI" id="CHEBI:132537"/>
            <dbReference type="EC" id="3.2.1.106"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycan metabolism; N-glycan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 63 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.106" evidence="1"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LSM8"/>
    <dbReference type="STRING" id="1330021.A0A367LSM8"/>
    <dbReference type="OrthoDB" id="14419at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004573">
        <property type="term" value="F:Glc3Man9GlcNAc2 oligosaccharide glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009311">
        <property type="term" value="P:oligosaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031335">
        <property type="entry name" value="Glyco_hydro_63_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004888">
        <property type="entry name" value="Glycoside_hydrolase_63"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054491">
        <property type="entry name" value="MGH1-like_GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412:SF10">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 63 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10412">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03200">
        <property type="entry name" value="Glyco_hydro_63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22422">
        <property type="entry name" value="MGH1-like_GH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="1" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannosylglycerate hydrolase MGH1-like glycoside hydrolase" evidence="4">
        <location>
            <begin position="442"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 63 C-terminal" evidence="3">
        <location>
            <begin position="720"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="931"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="958"/>
            <end position="968"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU369107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI17443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1011" mass="117831" checksum="960D523D0BA47697" modified="2018-11-07" version="1">MTAFNYVTDEEKRLRDDRERVKYWKKWGPYVAERQWATVREDYSSDGDAWSHFPHSHAHSRAFRWGEDGIAGVSDTHGFENIAFSFWNEKDDILKERLFGLSNPQGNHGESVKEAHFHLDNTPHSYMKFLYKYPQAKFPYQDLVEENSKRSKQDKEYHITDTGVFDKDRYWDIFIETAKEADDPDELLFRVTAWNRGPDPAPLHIIPQLWFRNTWSWGREPEDRKPVIDRHSATAAKSEHHSLGRRFFVLSPSPGVGSSGEDVIPELLFTENDTNFESLYGQENKQPYVKDAFHRRIVDGAKGVVNPKNTGTKCAAWFSFTEDGGVDPGECAVVRLRFSKSDIAFIDEEEFDNIFDRRREEADEFYYKISPLPMTDDLRNIQRQAFAGMMWTKQHYHFIWDQWANGDPAMPPPPPDRIGIRNEQWKHMHCDDILSMPDSWEYPFFAAWDSAFHCIPLAMIDPDFAKKQLDLFTREWYCHPNGQVPAYEWNFSDVNPPVHAWATFRVFKIERKMYDRQDLDFLERVFHKLLLNFTWWVNRKDANSKNVFEGGFLGLDNIGLFNRSEPLPTGGVLEQADSTGWMGFFCLSMLNIALELAKHRRIYEDIASKFFEHFILISDAMTFRAGQKNEQSLWNEEDGFYYDAISWGGPWIQQLPVRSLVGLIPLYATATLEPELVNKLPSFRKRVQWFVNNRCDLAERNMASIRKRGKGNRILLSIVSKDRLEKILKRMLDEDEFLSGHGIRSLSKYHKDHPYSMVVNNQKFTVGYVPGDSDSGLFGGNSNWRGPIWLCVNFLLVESLQRFYLFYGPEFRVECPTGSGEYMHLGKVSEEIQHRLQHLFIRTDDGRRSVNAGDNRLDFDEHWKNYLWFHEFFDGDSGRGLGASHQCGWTGLIARVIHDTGVNCRLPQTPRTPSIGMSHYFDDVFHRAVDPGTPTARRHRRSSTGRSIGARSDFDTNGLDEDTNEPELAEGRARERAEVDSHLHRYVANQLSEYMKNDRDYQHEDEFETQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZD1</accession>
    <name>A0A367KZD1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_8323</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000027">
        <property type="protein sequence ID" value="RCI07528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZD1"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI07528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="67" mass="7311" checksum="ED27C41A125949EE" modified="2018-11-07" version="1">MKVELIHISTIGNVLAAADTDIATADTVGCCWEEQISPGGKFTHDDLPCPPLSDIYESGINPYIYNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZE1</accession>
    <name>A0A367KZE1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Malate synthase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000047">
        <property type="protein sequence ID" value="RCI07352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZE1"/>
    <dbReference type="STRING" id="1330021.A0A367KZE1"/>
    <dbReference type="OrthoDB" id="186072at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004474">
        <property type="term" value="F:malate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.360">
        <property type="entry name" value="Malate synthase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011076">
        <property type="entry name" value="Malate_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006252">
        <property type="entry name" value="Malate_synthA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048356">
        <property type="entry name" value="MS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046363">
        <property type="entry name" value="MS_N_TIM-barrel_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902">
        <property type="entry name" value="MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42902:SF1">
        <property type="entry name" value="MALATE SYNTHASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20656">
        <property type="entry name" value="MS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51645">
        <property type="entry name" value="Malate synthase G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malate synthase N-terminal" evidence="1">
        <location>
            <begin position="10"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI07352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="120" mass="13577" checksum="167D640B2B7E8C5C" modified="2018-11-07" version="1" fragment="single">MSSTESILQGVSVQGKVDDIHRKILTPQALAFLALLHRSFDGTRRALLERRRLRQSELDRGVLPDFLPETRHIRENATWRGAVPAPGLVDRRVEITGPTDRKMVVNALNANVYTYMADLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZQ2</accession>
    <name>A0A367KZQ2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">factor independent urate hydroxylase</fullName>
            <ecNumber evidence="4">1.7.3.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Urate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_1618</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; urate degradation; (S)-allantoin from urate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the uricase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.3.3" evidence="4"/>
    <dbReference type="EMBL" id="LKCN02000026">
        <property type="protein sequence ID" value="RCI07637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZQ2"/>
    <dbReference type="STRING" id="1330021.A0A367KZQ2"/>
    <dbReference type="OrthoDB" id="9992118at2759"/>
    <dbReference type="UniPathway" id="UPA00394">
        <property type="reaction ID" value="UER00650"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004846">
        <property type="term" value="F:urate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019628">
        <property type="term" value="P:urate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.270.10:FF:000001">
        <property type="entry name" value="Uricase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.270.10">
        <property type="entry name" value="Urate Oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002042">
        <property type="entry name" value="Uricase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019842">
        <property type="entry name" value="Uricase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03383">
        <property type="entry name" value="urate_oxi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42874">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42874:SF1">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01014">
        <property type="entry name" value="Uricase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00093">
        <property type="entry name" value="URICASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00366">
        <property type="entry name" value="URICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="5" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI07637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="422" mass="47021" checksum="215DA883AD218104" modified="2018-11-07" version="1" fragment="single">VCPYSIQLFFPVAAAYHPTHQESRPSPALRSPLSVRRAPACPRTTYSQCTLNRSPIHGSLLVHTKNLAPVLPINPACSALRLLTRLTLRFRTSSQPTRRLSCHVARRSPSSLSLAPNYAAPSLKPTMPYVSAARYGKDNIRLLKVSRNADTGVQTVFETTVCCLLEGDIDTSYTEADNSVVVATDSIKNTVFILAKQHPVNPPELFASTVGNHFIQTYSHIHVANVSVVTHRWLRMDVDGKPHPHSFIKDAGETRNVEARVSRRDGIAITSSIAGLTVLKTTGSAFHGFVRDEYTTLAETWDRLLSTDVDARWRWSEFPNMQAIEKSVSRFDEAWEKAREITLKLFAIDNSPSVQNTMYKMCLQILDAVPGTDSVAYSLPNKHNFELDLSWHKNLQNTGQHAEVYVPQTCPNGLIKCEVSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L046</accession>
    <name>A0A367L046_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutathionylspermidine synthase pre-ATP-grasp-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_5709</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000024">
        <property type="protein sequence ID" value="RCI07781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L046"/>
    <dbReference type="STRING" id="1330021.A0A367L046"/>
    <dbReference type="OrthoDB" id="64566at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005494">
        <property type="entry name" value="GSPS_pre-ATP-grasp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03738">
        <property type="entry name" value="GSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutathionylspermidine synthase pre-ATP-grasp-like" evidence="6">
        <location>
            <begin position="4"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI07781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="416" mass="47171" checksum="4C2AE94FC46A00B7" modified="2018-11-07" version="1">MDLVKKAGEDVFQMCCEAADYLVEHPDVITSDMAIPAFTLRQIQKSWNREPAWASVYGRFDLCFGGLDHPDPALRTPRFYEFNADTPTCLVEAALIQAHWLQQTGHGNDQWNDIYPRLVEAWKRNLTLVEKEMGHKVPFVHFATASGDCDGEEAINTVLLAQSCRDAGWPTRSMAMEQVSLSPVDGRFYDQHGDHIDVIFKLYPYEFMVKEKFGEACFRDMDSVGGTVWIEPPYKMLWSNKALFALLWKLFEHDPRSKWLLPTYLERDAPASLTSYARKPIYSREGLGIRLHQDGRLVQEQGINSMYGKEGYIIQGLAPPPDFKDGQGKSRYAVLGLWFIDGEPAGLGVREADSLITNDYTPFVPHSISDGPICYTRREMPHSDEIEAALRVDQYAYIQDGADVLAYIESVVGMSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L090</accession>
    <name>A0A367L090_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Yippee/Mis18/Cereblon domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_5826</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000023">
        <property type="protein sequence ID" value="RCI07836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L090"/>
    <dbReference type="STRING" id="1330021.A0A367L090"/>
    <dbReference type="OrthoDB" id="5396360at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="388"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="251"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="429"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="469"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="494"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI07836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="505" mass="55325" checksum="72F29628B1508220" modified="2018-11-07" version="1">MADTLIVCKCSNCETALGSLTNEWIQVGKNYITSTQDVGHLLVAASGDVRFGDVGTLIAGCQLQVAVCAKCDFNLGQKCVKSPADHALNDGQVVFRVTSINLRLASDMRRKVAPNIKRVLNLKVHNDQPKKEQADASPETPQEYDAAPNRYLVQIQNELEAHRQQIGQIGRTGVYVVSNFKSAVARVDWQIRQLNESVDGIRSDADRQRHALDLLESKVADAKEEEAKRVCPCEAIVARLDKKLQDTDVLVTELRRALQKSQSESETLRQRLSLTREELEVARGDAATLRADADEAKNAAHESLAMSQEYACEVSSLRREVKQLQAQMKDERILSQPAPAAASFPSHELDILASSISKIGNRASQIESLQMEFDLFKTRLQRLEAARAGVAHSNRGGMAATTSAAADDENEPPGYNGGTLRRKRAYIGGREDMRGGFDKTSTKRAALSMSDRDSGISTGNGRDGEPYRSCSSGSTKATSLSGPRRSREDVEDYTAVRRESWSGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0A1</accession>
    <name>A0A367L0A1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DOA4-independent degradation protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_1631</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000026">
        <property type="protein sequence ID" value="RCI07642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0A1"/>
    <dbReference type="STRING" id="1330021.A0A367L0A1"/>
    <dbReference type="OrthoDB" id="10252926at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="184"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="14"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="219"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI07642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="228" mass="25457" checksum="8F5A2192EEE739AE" modified="2018-11-07" version="1">MNAKWAFGKRITPAERLRKNQRMLDKAIRELDQTRVKLEKQEKTLIQQIKTSAKNGQMGACKIQAKDLVRTRRYVEKFFAMRSQLQQISLRLQTYRTNEQMMQAMKGATMALGSMNKSMNLPQLQRIAMEFERENDIMEQRQEMMDDAVDDAMDVGIEEEGDEVVDQVLEEIGIDFNQAVGETPTALGNSSVSEGKIPQAVGGGGGGGGGGGDPVDDDLQARLDSLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0L0</accession>
    <name>A0A367L0L0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_7807</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CCC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000022">
        <property type="protein sequence ID" value="RCI07951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0L0"/>
    <dbReference type="STRING" id="1330021.A0A367L0L0"/>
    <dbReference type="OrthoDB" id="73465at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="FE(2+)/MN(2+) TRANSPORTER PCL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI07951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="262" mass="27761" checksum="6889E392E79ECE19" modified="2018-11-07" version="1">MPSTAETTPLLPSSPERQKPWPPKPAAALPPKPSPTMDLHDTLHHVIIGFSDGLTVPFALTAGLSSLGSSRLVVLGGLAELFSGMISMGLGAYLAAVTERNPPPPAAATAQDDDLYSLLREGYDLSPAVVRPLVEELSRDASLSQRFREHLVRDKSSSRHHSSSSDSRPCLAGLTMGTSYFVGGLIPMLPYFFAARVRDALLVSVGVTVVTLLAFGYVKDYLAVRSHRAGCWGALQTLVVGVLAAGISYGIVRALDASRGEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0M6</accession>
    <name>A0A367L0M6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Clavaminate synthase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7812</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000022">
        <property type="protein sequence ID" value="RCI07985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0M6"/>
    <dbReference type="STRING" id="1330021.A0A367L0M6"/>
    <dbReference type="OrthoDB" id="438224at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000033">
        <property type="entry name" value="Clavaminate synthase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48420">
        <property type="entry name" value="NON-HAEM DIOXYGENASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48420:SF1">
        <property type="entry name" value="NON-HAEM DIOXYGENASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI07985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="364" mass="39516" checksum="461252439377DE49" modified="2018-11-07" version="1">MAPQSQAVTVSLKDLINDTISFETLQQAFGPDSLGILIVKDVPEQFPKLRRLVLSYASYLGNLPAAELEQLENPKAKYLTGWSRGKETLKNGQVDTFKGSYYANCAFYVDSSLECARPTPGFVLDTFPEYLAPNVWPSESALPGFRSSLTSLCCLVIDVAVLVARACDRFAEKDIPGYPPGYLQRIVCTSSTTKARLLHYFPREGDLIDDDAGDDDWCTTHLDHGCLTGLTSAMFVDESVTSPLVASAVSLGAAPVVPPLEELAESPDPSAGLYIKSRAGETVQVRIPRDCIAFQTGEALERITAGRFKAVPHFVRGPRAGDGRVARNTLAVFTQPNLAEVVDMEKQQTFGEFARGVVAQNTVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L187</accession>
    <name>A0A367L187_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Dihydroxyacetone kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L249_6342</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13941"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.28"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>dihydroxyacetone + ATP = dihydroxyacetone phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15773"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.29"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Polyol metabolism; glycerol fermentation; glycerone phosphate from glycerol (oxidative route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dihydroxyacetone kinase (DAK) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L187"/>
    <dbReference type="STRING" id="1330021.A0A367L187"/>
    <dbReference type="OrthoDB" id="1724672at2759"/>
    <dbReference type="UniPathway" id="UPA00617">
        <property type="reaction ID" value="UER00669"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050354">
        <property type="term" value="F:triokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019588">
        <property type="term" value="P:anaerobic glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.340:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1180.20:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10440:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase, DhaK subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10440">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.20">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012734">
        <property type="entry name" value="DhaK_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050861">
        <property type="entry name" value="Dihydroxyacetone_Kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02361">
        <property type="entry name" value="dak_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629">
        <property type="entry name" value="TRIOKINASE/FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629:SF4">
        <property type="entry name" value="TRIOKINASE_FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82549">
        <property type="entry name" value="DAK1/DegV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="DhaL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="15">
        <location>
            <begin position="9"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="DhaL" evidence="14">
        <location>
            <begin position="399"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="359"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-hemiaminal-histidine intermediate" evidence="11">
        <location>
            <position position="224"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="59"/>
            <end position="62"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR612734-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR612734-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCI08200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="612" mass="64190" checksum="0A3C1BBC19DFFCFC" modified="2018-11-07" version="1">MSKRHLFNSADGLVDKALRGIVAYNPSLRLDEVNRVVVDGSRDSSSSSSCTVSLISGGGSGHEPAWAGYVGSNMLAAAVQGDVFASPSTRQIMAAVDAVPGREGVILVVTNYTGDCLHFGLANERANSGHGRCRILICGDDVSVGRRRSALVGRRGLAGQVAVLKVMGAAAGAGSSLDDVYDLGVAVSTQVVSMAATLDHCHVPGRTGHGPLAEDEVEIGTGPHNEPGFKKLSPVPEPAELVRQLLRHMLDDKDDDRAYVRFVPGDETVLVVNNFGGMSPLEMGALVDEVLQQLTGEWEMEEPVRVYAGTLETSLNAPAFSLSVVNIAAAARNCNRYSVDDIKAFFDAKTNTCWEAVAGSQAGHGTPRRRRRREGQLVKPAPAPPKSVNPGRDLGVDAAVLDRMLRGACASLVEAEPDLTRWDTVMGDGDCGQTLKSGAAAMLAALDRGLAKSGSVGEVLVELEDVAEGKMGGTLGGILCIFFVALRSAVEEEMGRGSSASSSSSPAAVWASALSTALDSLRRYTPAKVGDRTIMDTLIPFSDAMKASGFDDGVRAAVKGAEATRTMKPKLGRASYVGARDDDDGHEMSPDPGAWAAMLVVRALQRGFQGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1H7</accession>
    <name>A0A367L1H7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Histone H3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L249_8362</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the histone H3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000020">
        <property type="protein sequence ID" value="RCI08275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1H7"/>
    <dbReference type="SMR" id="A0A367L1H7"/>
    <dbReference type="STRING" id="1330021.A0A367L1H7"/>
    <dbReference type="OrthoDB" id="842664at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000010">
        <property type="entry name" value="Histone H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0488">Methylation</keyword>
    <keyword evidence="11 12" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="14">
        <location>
            <begin position="44"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCI08275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="136" mass="15392" checksum="9AF51E808E698349" modified="2018-11-07" version="1">MARTKQTARKSTGGKAPRKQLASKAARKSAPSTGGVKKPHRYKPGTVALREIRRYQKSTELLIRKLPFQRLVREIAQDFKSDLRFQSSAIGALQESVESYLVSLFEDTNLCAIHAKRVTIQSKDIQLARRLRGERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1K3</accession>
    <name>A0A367L1K3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calcium-binding protein NCS-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_8941</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the recoverin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1K3"/>
    <dbReference type="STRING" id="1330021.A0A367L1K3"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000009">
        <property type="entry name" value="Visinin-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028846">
        <property type="entry name" value="Recoverin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055">
        <property type="entry name" value="CALCIUM BINDING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23055:SF178">
        <property type="entry name" value="NEUROCALCIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00450">
        <property type="entry name" value="RECOVERIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="60"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="96"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="144"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="319"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="319"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="340"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00071944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI08320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="469" mass="53059" checksum="A0DA2088A2273292" modified="2018-11-07" version="1">MGKSQSKLSQEQLVELQKSTHFDKKELQQWYKGFLKDCPSGMLTKEEFQKIYRQFFPFGDPSSFADYVFNVFDSDKSGTIDFKEFICALSVTSRGKMEDKLDWAFQLYDIDGDGKISYDEMLQIVEAIYKMVGSMVKLPEDEDTPEKRVRKIFRMMDKDENGSLDMDEFKEGSKRDETIVSALSLYDGLVHVKLISYPHDPVGGEEISDAEEETFLLYALQPLSSQDLGFVDPRAGSVQVMVGDREVTLHQSPALLASDREAALLGALHDPKHILELGCGISPLNGLAFTSRASSYVFSDQSYVQRLVRRNMSAAGLAVEERRQDDDGKRSSRPLQLQHQRGKKDHAVRTRQGRNRNSSRLDAAAAAAAAAFSFRALDWDADVVTSSFCHPASAFDLIIASDCVFNEALVPNFTRTCVDQLRSHDVFRAWIHLFLERFHVWRVPGEMLPVELRPESGFVIHVAILRHHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2W4</accession>
    <name>A0A367L2W4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2W4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="96" mass="10885" checksum="359DBABCE69D4742" modified="2018-11-07" version="1" fragment="single">QEAQGKGAEQQVHPTQLHPGFKDALAPTYHPRPPSVLTDGREPCGARWRRVSSSPVWSVTAGFSTRRSYLGGYGDVCYDRRHSKEVRYNINKQFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2Z1</accession>
    <name>A0A367L2Z1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">VIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_4653</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2Z1"/>
    <dbReference type="STRING" id="1330021.A0A367L2Z1"/>
    <dbReference type="OrthoDB" id="1729737at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013694">
        <property type="entry name" value="VIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737:SF4">
        <property type="entry name" value="VON WILLEBRAND DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_4G01160)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45737">
        <property type="entry name" value="VON WILLEBRAND FACTOR A DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08487">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13768">
        <property type="entry name" value="VWA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00609">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51468">
        <property type="entry name" value="VIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VIT" evidence="4">
        <location>
            <begin position="88"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="VWFA" evidence="3">
        <location>
            <begin position="388"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="753"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="757"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="799"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="837"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="857"/>
            <end position="875"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI08796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1142" mass="126193" checksum="F7AB62281762F5B2" modified="2018-11-07" version="1">MSHRHLTKRLASGVLFSLPADPSTAIADIRPFKGKQKKHAQVSYHHGPQGLGQFANLAAASDDGYGMFPVFDKSLDVDPDDHLVPAGPPSEKKYPSAITLCLPLLSVTADVTVDGIIAVTELRQSYHNPSTINIPEARHTFPVYDGAVVSSFECTVGDVRFLKGVVKAREQARQEFEKARREKRETAGVLEEVTPEILEISLGNIPAKTTVEVKLTYVHELKVVTMEEEKSEGLDITIPLSIAPRYGTPAAKAPAPELPANRLDIWIRVLDDGSINPDGCRVESEHEASYEGCESARKQVTTSLAELASLAEPSAAKPQMQFVWHYASGSAMLKKDFVLVLQKRQGDRLRSRAVLAPANGNGHAALMVHLRPNDIFNNAVQPRNFTGEILFLLDRSGSMGWTNDGDGTLKIETMRAAMALALSGLPRTCVFNIISFGSEVRGLWHESQSAGDADKVKDARAHIPYINSDMGGTEVLLALESALKHRMESRPSTQMILITDGEVGSELNDEIISFVWKTRRDLGHKVRFFTLGIGDSVSHLMVEGIARLGGGYCDVVDVVKRPRWEGRFNRLLRSAMEPDSWTFDVDLGPGYERRSLLDFKLGGGQLKDTSAIPVIQAPFPIPPLHPYNYESVFFLIDGNGKPPEKVFLRTTTEGAKKKSYALDVETVASNGGAMHHLAAKAILLGLDHETKIQGSETNLARVNAESLGTRYSVASKWTSFVAVADDREAHEVDLYKSPFQQIDLQELLSLDDDDSDVYSSSGSDGYDQMSAPMPNSMPGQTILRMPNSMPDAMPSRLTPLPPTLPPPGRKWGPVKDTVWKRHRTSDAARPAVSEMDSPLRESRRQDWSYEPSSSPLSEKKKSSSSDDSLDDRPLRQMEFPVSPPPVWDDGRFNMPSGCNMPRQRMSLDIVDAQGTAMETESVSESEESGELEAYHPSADGPITCQDAVWSQTTDGFALADVIRTKLHGEFCNETDASLRKLLLELSPSVELTDVLVDTIMMMAYFQTHLAAEEDAWCLMMDNAERAVLLSLGFEEDQEDKLTGIYEVLRQAVAHTHFVQALKTSSTERTTQEDTTLEANIKSCPICNYSFDFVKRGFVCGHDACFDGARVVWRTWDEFWDHQVDNGHLNCPETVTEDNVVEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L345</accession>
    <name>A0A367L345_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">40S ribosomal protein S29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_4827</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L345"/>
    <dbReference type="STRING" id="1330021.A0A367L345"/>
    <dbReference type="OrthoDB" id="10252683at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.830.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="entry name" value="30s Ribosomal Protein S14, Chain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01364_A">
        <property type="entry name" value="Ribosomal_uS14_2_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_uS14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023676">
        <property type="entry name" value="Ribosomal_uS14_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_uS14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039744">
        <property type="entry name" value="RIbosomal_uS14_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_uS14_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004424">
        <property type="entry name" value="PRK05766.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12010">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12010:SF2">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI08827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="94" mass="10958" checksum="A72924DD31D83090" modified="2018-11-07" version="1">MVVRAQSRKSLSDHQHHAPATMSHQSVWNSRPRSYGKGSRSCRVCKHRAGLIRKYDLNLCRQCFREKSKDIGFNKVSPERGSRGDDFFFSLRLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3A9</accession>
    <name>A0A367L3A9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_4935</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI08916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3A9"/>
    <dbReference type="STRING" id="1330021.A0A367L3A9"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016852626" evidence="2">
        <location>
            <begin position="25"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="409"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="428"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI08916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="673" mass="74022" checksum="9BF8C47B57E2F1FE" modified="2018-11-07" version="1" fragment="single">MPTTLQAVFCLALLLSPWPALISAVPLDSEDDNNNNPSLPPLSIDNSSHPLLLLLLKRSPIRQPKNPPATRGPPEVDEDGYLRPAAPRSGTYENVRPIHPGTRPRQPSPTPPSSRRPRMRFLTEPQRPSRLRRMAAFFHGLVSPNQGRPWPQSSPRQRHRQDSPERSMRRFPDEIPLPGEESRALLSFGRQDQDSSTTAPALPPPRMRQRPKPTAPRPQDIEQGTTEPSSVCPPLEEAGKEKGPVKLKAWPESLPTGRRPRHWPRIATDREDDDDRSDNDRVYRFQDRNGQVHWSFPSPDSVFLLDSTTPADLFPHPSPSRLLPPPRPTGYSPDGVPQYEHWLWVTRSGDGQRAFQLVPKAAGCYTPLRGSIGSTEGFCDNEDAKPVEAGYIPLLFRFPGATGSEWHFAPQPASASPSPEPIAGPSRPRQTTSLTTAQGGRNGRGGGGRKTGKGAVAEDFSLVLSRLLTFLLSSGLSLAQAQAINQGLQNMQGSTGELVQSLLYDIFTYVGCFVEYDGYLPDNVGALVVAYMPHLVDVILMLLHSTTPSNNGHRSKRGEATTSLSTDRLAEGFCTRFRTCQMGIPEDFQTSLYLDCARSTAGDPVDLSLNMFSRKAVCDAFAKAENRTGMLPAIDIDCSWDQDPAKQHPSVYMCNNNNFQGPCTTVAASLGQC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3F2</accession>
    <name>A0A367L3F2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Developmental regulatory protein wetA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_5058</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the wetA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI08960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3F2"/>
    <dbReference type="STRING" id="1330021.A0A367L3F2"/>
    <dbReference type="OrthoDB" id="2575228at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040112">
        <property type="entry name" value="WetA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22934:SF25">
        <property type="entry name" value="DEVELOPMENTAL REGULATORY PROTEIN WETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22934">
        <property type="entry name" value="PROTEIN ESC1/WETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0183">Conidiation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0749">Sporulation</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="187"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="462"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="635"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="244"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="474"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="526"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="543"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="577"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="588"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI08960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="686" mass="71719" checksum="235B11C95D4E31CB" modified="2018-11-07" version="1">MAFWTMPFRPDAVDGGSRDGSFYWQDLDGGPGSGDMSSDFFGQFVDLDAEGPPPSAGDGFMSGPGDSLFLMDEPQHRVSDSTGSSGVSTADELDFLSSSSHVGPAISHEIDPRELALGVDPLTGPPPPQPHRPSMSETDLSRLEGISLDSPEKAAAAAAAAVAAAVAGVANGPTAHQHVAASASAVAPVSDPCDPSSPTPPNTVARKPNKFVEALSSTIRKATTIRKTRKPLPGQRDGSPTPEQQQPQQQQHRQQEQQLKPPKQRRGRTRAVTHGDAPHSPPMQHPDDSQFINGFCEDPFHEGQQLPPPPPLSTSSMPYFGQAGIDTPLESPGVKSEPGQFIPMAGGPHQQTQQQQHHLQQQQQQQQQQQNHHHPQQPPAADQMLLPDQWAGSIPHEYVTAQEATWWDMSMLPPGPGEGEFASHHRSVNLASHAQHSGLPYEYAPMADAGLMIHMPQPRPSVAGDLSVNGQAYLPPPPPPPPPSQQLPGAAQAKGAASERQHRPPRAKSSGARHMSCSPVRKQRGPSASPNPGQSSGPRSRHSSGASVSSVRSASGRLPASMPGTPCSVRKRRSRDVSSAGGSFSGESGVGGGGGVGVGGLGLGDGIGLGIGGLGGGEGGIGFVNFTPNDGSLLMTGVAPSGSSKTKARREKEAQERRRRLSEAALKAVAAAGGDVDKLLEQGFAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3G6</accession>
    <name>A0A367L3G6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LIM zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_5035</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI08970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3G6"/>
    <dbReference type="STRING" id="1330021.A0A367L3G6"/>
    <dbReference type="OrthoDB" id="1112565at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030695">
        <property type="term" value="F:GTPase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08368">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09397">
        <property type="entry name" value="LIM1_UF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.10:FF:000105">
        <property type="entry name" value="Similar to LIM domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24205">
        <property type="entry name" value="FOUR AND A HALF LIM DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24205:SF16">
        <property type="entry name" value="GH01042P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00478">
        <property type="entry name" value="LIM_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0440">LIM domain</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="438"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="LIM zinc-binding" evidence="7">
        <location>
            <begin position="501"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="30"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="560"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="178"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="296"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="362"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="580"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="599"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="620"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI08970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="631" mass="67818" checksum="A91A8986AA5E3C71" modified="2018-11-07" version="1" fragment="single">MAVPRESFLPTIKCSSCGNQVEISMMGEHLCGGPVSPPPEPKKRFDDDLRQTSYSARDRRTPPQLNTNVANRPFGSRGQLTPVSQPDDSRDTSPVGYGQPSRSPMRQQRPGGYGGFKDDSAEGEGQRQAAGGFLDRVTNVLGSGPFGAVDKASSVRRFPTRKESLGNFHGPDDRPGTGYSTASSNLSATIAPPKAPRKNGYGGFGPPQTSSAADMDAPSPEPSSTPSDPYRGRPMRSDGRSPMMDRFDDERKASMDGRRLQQQQQQPPRSTPFGQRERRPSNAAAEFGVGNPYHVSSNSASSGYSSFSDLSQSTAQTSPARSYRDKDVDELQTPMDSLRFKSDPRRGGGGETPYGSEPRGMTTTTTTTTTTTTPSLRYGSSPRYGSSPQRGPDRYGSSPQRSAAGRYGGGGDDYYYGASGGSRGSSRSGSRGPVISRGDCKACRLPIKGKSISSADGRLTGKYHKACFVCTTCSEPFRSTEFYVLDDKPYCEQHYHKLNGSLCGSCGRGIEGQYVEDESRIKYHIGCFRCLDCGRSLSDGYFEVDGKAYCERDAWRRTQPPPTTTSYGGAEPDQPYRGGSAVGGSRSAGGGLSERGAGRRAASISRGAAAAAGAQQPRRQMNKRMTRIGRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3K1</accession>
    <name>A0A367L3K1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptidase M43 pregnancy-associated plasma-A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_5090</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Secreted metalloproteinase that allows assimilation of proteinaceous substrates.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M43B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI09011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3K1"/>
    <dbReference type="OrthoDB" id="536211at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04275">
        <property type="entry name" value="ZnMc_pappalysin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008754">
        <property type="entry name" value="Peptidase_M43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47466">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47466:SF1">
        <property type="entry name" value="METALLOPROTEASE MEP1 (AFU_ORTHOLOGUE AFUA_1G07730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05572">
        <property type="entry name" value="Peptidase_M43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M43 pregnancy-associated plasma-A" evidence="10">
        <location>
            <begin position="149"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI09011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="261" mass="28725" checksum="32CCCF6B007F5DF7" modified="2018-11-07" version="1" fragment="single">LRRLPLAELADMKENETVKRIKARTDLSIDLFVHVVTTPKEKNYDTIYKQVNVLNDHFGPGGITFRLKRVDWTFDAVWAAGDSGTAMKRALHRGNNMTANLYVLDSVAAGLGICSFPWNLDEADGPIQDGCIVEASTLPGGGKVHYDQGKTAVHEMGHWLGLLHTFHNGCDGDGDHIDDTPATDGPAFRCPVGRDSCPDRPGLDPVHNLMDFSYERVAFLIVVEDVFTDHVAVPAPRSSRPGSSRECIICGQDTAHYRFPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3W3</accession>
    <name>A0A367L3W3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">methionyl-tRNA formyltransferase</fullName>
            <ecNumber evidence="1">2.1.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_5043</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.9" evidence="1"/>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI09098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3W3"/>
    <dbReference type="STRING" id="1330021.A0A367L3W3"/>
    <dbReference type="OrthoDB" id="10268103at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004479">
        <property type="term" value="F:methionyl-tRNA formyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd08646">
        <property type="entry name" value="FMT_core_Met-tRNA-FMT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002376">
        <property type="entry name" value="Formyl_transf_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036477">
        <property type="entry name" value="Formyl_transf_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041711">
        <property type="entry name" value="Met-tRNA-FMT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11138">
        <property type="entry name" value="METHIONYL-TRNA FORMYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11138:SF5">
        <property type="entry name" value="METHIONYL-TRNA FORMYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00551">
        <property type="entry name" value="Formyl_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53328">
        <property type="entry name" value="Formyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formyl transferase N-terminal" evidence="3">
        <location>
            <begin position="132"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="422"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="435"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI09098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="446" mass="49058" checksum="C9D59104695E671A" modified="2018-11-07" version="1">MASSSDGWDERHPVSTQQQPVFLTAPRFITSTEPIDRLPRRRPRGNNAYLPGGLAATLQEALSEVKGKADAAAAAEKDDDEEEGEEDAIHVDELNSPAMVLLYSARTLFPCLVRAGRRRFESTTTRASDPLRILFCGSDAFSCESLRALHRELGSGAVEALDVMVLPPKRMGRGMKQLRQVPCRALAEELRLTVHERETFTKWEVPLGTNLIVVVSFGLFVPPRVLKSAKYGGVNVHPSFLPDLRGPAPIHHALLRGDRHIGVSLQTLDEKRFDHGVVLAQTPPPGLVVPSAATIQEVTALAAKQGAEMLVRALLRDRLHVPPHRDAGWGWKAVESENGAGGLLRHAPKVTKADSRIDWRTWTSGEEFGRRVRVFGTVWTKALDLVAKKRRRIIFKSVQAVDGDHDVDTLFAGPRGRVCFDENGEEQDDGLEQGGGERRVGDGCEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4H4</accession>
    <name>A0A367L4H4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_1555</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4H4"/>
    <dbReference type="STRING" id="1330021.A0A367L4H4"/>
    <dbReference type="OrthoDB" id="25503at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12909">
        <property type="entry name" value="SPRY_RanBP9_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035782">
        <property type="entry name" value="SPRY_RanBP9/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="169"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="CTLH" evidence="4">
        <location>
            <begin position="468"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="530"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="216"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="530"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI09311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="681" mass="75381" checksum="9BA9301F28C137C5" modified="2018-11-07" version="1">MNAPSGQGSSSGLPGSDPTGQSSSAYNSSATPPFYSHPARISALSPDGRLLLGSPTGFSVARRAEGSNMDASASDDILHVWNVSGSLPSFSRAFDMFTQSFESESSTQGCFFVPSYLRGTTYIKRLQEAYRSKSQALREPQRPLANGGTAFTQLPLTPGAHRGLAHTIVERTPAPEEDEQDAAVAPLPSRWNKDDAWHGIDLQPDDLSVKYTGPKNNHERDHEASATRADHHMPPQCGLYYYEVQILSGKHDDTTIAIGFSTKDTSLSRPVGWEPDSWGYHGDDGRCFSGQNIGRSYGPTFNTGDIIGCGVNFRENSAFFTKNGVKLSENHRSDTRVCVFRLTETWSLGVAFHEVVRGKLYPSVSLKKPGEAILVNFGQVPFVYNIDDVMREERKKMQQEISNADTTKLEPGMSETDLIQTLVLQFLQHDGYVETARAFAEDMRAQRQALSLDPTAEVAGINIKDEEDANNRQRIRKAILEGDIDRALKYTNAYYPQVLQDNEEVYFRLRCRKFIEMVCKAAHMRAATESRRNNSGHEMDIDGETTGWSDSMDTDGPDQTELIRLEQDMLEFGQALEAQYANDQRKDVSQTLGEIWALVAYSNPLKEPLVSHLLDRKGRAAVAEELNSAILTSLGKSSRASLERVYAQTSVLLEDLRRKGGPGAFVSLQDLLEEIAQAPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4N5</accession>
    <name>A0A367L4N5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_3760</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000015">
        <property type="protein sequence ID" value="RCI09368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4N5"/>
    <dbReference type="STRING" id="1330021.A0A367L4N5"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000017">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF12">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="467"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="510"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="63"/>
            <end position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI09368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="572" mass="63244" checksum="9B90371D4D5C336A" modified="2018-11-07" version="1">MSDPEKSASGVGESKVVEASPAFASTFQDEDKWTRCGLSLKSFQKRHYGHGVVELDRSIKTRHLHMIAIGGSIGAGFFVGSGSALSKGGPASLLLCFSIIGFMVFNIADIEEPVFALGELAIMYPISGGFYTYATRFVDPSFGFAVGWNYLFLWLSVLPLELTVCSLVIQYWDERTSVAVWITIFLVAVIVINIFGGLGFAEEEFVASTVKLTAITSFLIIALVLVLGGGPREGRYNEYWGVRYWFEPGAFRNGIRGFCSVFVTAAFSLTGTELVGLAAAETRNPVKSLPGAVKRVFWRIIVFYILGLFFVGLLIPADDPRLLANKAITDVKASPWVLIGLYAKLKGLDHFMNAIILISVLSIGVSSVYGGSRTLTALAQQGYAPKLFTYIDRSGRPLPAVIVIILTGPLAYVNLSASGPTVFEWLQALSGLAVMFSWAAICLAHIRFRKAWAHNGHSVDEIPFQALLGVWGSWISLIMCFFVLAAQFYTAIAPVGKPGFNTVEGFFKDWLAFPVVMAFWLLGFLWKRSGWLRIDQIDVDTGRRELDWDEVRAYREHVQRLPSWRRALHKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L526</accession>
    <name>A0A367L526_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phospholipase/carboxylesterase/thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_3921</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L526"/>
    <dbReference type="STRING" id="1330021.A0A367L526"/>
    <dbReference type="OrthoDB" id="2418081at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF63">
        <property type="entry name" value="PHOSPHOLIPASE_CARBOXYLESTERASE_THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="3">
        <location>
            <begin position="22"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="180"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="182"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI09536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="329" mass="36774" checksum="89D4928B782BA0BB" modified="2018-11-07" version="1">MSSPACVRDPHLTGDRIQSLTHVVNASHTHTHTFILLHDVGSNGSMFGHDLLRLGRTSTGKSLDWLFPGVRFVFPTAVRRPCQAFHQLRIGMWFNMAQLQQPCFRQDLQRDGMATSSRQIISVLRGEMRRLPAEKIIIGGLGQGAAMSLVVLLTLTFKLGGVIGMSGYLPFWFELQMMTADDSSDEDEDEDEDDEDDDDGDALYTEEDDQAEEKGAEERNKLCRSISPSLDPCIQAQLFARKLLNMCMPEHPSSENTSVGTPVFLAHNDNIEAVPVREGSQAASALEMVDYEVRFRYYHKPGQGYQVPMQIDGIVSFIRSKIGLIPRPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L587</accession>
    <name>A0A367L587_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBX domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_3909</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Directly interacts with VCP. Interacts with UBQLN1. Forms a complex with VCP and UBQLN1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L587"/>
    <dbReference type="STRING" id="1330021.A0A367L587"/>
    <dbReference type="OrthoDB" id="2445133at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46424">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46424:SF1">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23187">
        <property type="entry name" value="UBX7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00166">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0834">Unfolded protein response</keyword>
    <feature type="domain" description="UBX" evidence="7">
        <location>
            <begin position="262"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="111"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="409"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="143"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="195"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="415"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="444"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00041575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00046062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI09568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="466" mass="51728" checksum="F59B51C5DE9A1B50" modified="2018-11-07" version="1">MFYQGSLQEGISAAVGQQKLVHLGSDDNEESKTWENDFLREQPLDELIASRAIALRLEAGSESAAFLAQIFPLPKTPTVVIMKHGELREYIAGETTKDDFVRRVQSAFDLAPTSDPSLTMADDVPPSTANGATSQSSAPQEADNVRRALAERAAKLQAEKDESDRREKDERAKRKAKAAAEAQAGADTAAARTHRMAEELQKQRQKKDEERRRILKRIEDDKHERRQRSAQRQQNRIDGLQTGDVASSLVKAPESKLPSTTRMGDMASIQVRIFDGSTIRSRFKTSAHFGEVRAWVDENRSDGSAPYTFRQLLTPKPNLAIDEEDETKTLADMGLAPSSTLILVPVQKSSTAYEAKPRQQLQQQQQQQQQQLQQQNLLARIIFAISALAAWLTELLGFGGRATAATAPVLKPESAESTSSAVASGQGGHRRIRDFDNVIDQPRDQQQLYNGNSLNFEPRPEDENDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L595</accession>
    <name>A0A367L595_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin 3 binding protein But2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L595"/>
    <dbReference type="STRING" id="1330021.A0A367L595"/>
    <dbReference type="OrthoDB" id="4991875at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40640">
        <property type="entry name" value="ANCHORED GLYCOPROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40640:SF1">
        <property type="entry name" value="ANCHORED GLYCOPROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017059826" description="Ubiquitin 3 binding protein But2 C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="23414" checksum="72C291D97F4AF165" modified="2018-11-07" version="1">MAGLSPGCANVFLTLLTFCALGLAGHPTTPPTPTPIASTAHIFLPYYPEEAWHPLRGSILSIARYPILPANKKTNETAYDIFCPAQTPPPCDLALDFPFIVTKGPSMIRFRGTLTSTYTANLECKAAETTTVATCSGYSSYKSGYTNGLITGPTEISWTSTLTTGVEWAVITLSEKPKATGHHVEVAASSNAAASVVRVEERLLIMMAAVAMIKSVGVGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5A5</accession>
    <name>A0A367L5A5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5A5"/>
    <dbReference type="STRING" id="1330021.A0A367L5A5"/>
    <dbReference type="OrthoDB" id="5138418at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="342"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="469" mass="49874" checksum="3E2C99D02333C0B0" modified="2018-11-07" version="1">MAFSSGGAFRTGGAHHGLFRPPLPPSSSACLPAGRRGLEKRRPRYGATSPSRRNVVTEDDEDDQKLAPKTPNPAPAIAAATTTAAVHNYALAGHLDTPHSGPEDGSLLDESMYSDSNYRKALGSKRPHPDFDVADPSRPTPLFSLPAEPMPQRTWSALALDTIGDVVGRVWDFCTAGAFRGFYAGGGEGYYVPPEEVSYCGGVEKQVPGHYPRGSYSGTSDVGGPDGGPTSMPMMMGFDGGDYDLSSPTFPAAKRRQTSMADELGRNWVMVHEPREGNGARRRTSFQRARTRGVVTGRRGTLPIRPHTMCVSSSISSSGTTPWSGAAERSWLAAPPAPARSPSPKKQSSRASTTTMSAVGGVMASTATTTASGGNNSRRRTTLLPGTAHGRTHSNASTASSRGAADEVVEASPRLDAEAKKLAARRKMEERDADVRIEAFNKQLQAMIRQGREALGTMIEVDGGWEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5C2</accession>
    <name>A0A367L5C2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_3753</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000015">
        <property type="protein sequence ID" value="RCI09422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5C2"/>
    <dbReference type="STRING" id="1330021.A0A367L5C2"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508:SF9">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORT PROTEIN (AFU_ORTHOLOGUE AFUA_2G09450)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23508">
        <property type="entry name" value="CARBOXYLIC ACID TRANSPORTER PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="342"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="441"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="69"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI09422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="514" mass="55222" checksum="FECCD4EE55AA699B" modified="2018-11-07" version="1">MPSTPNPDKPADDLAKGILPTALQSWHDLFTLRQRIVLDDKGSCAWRDPAPISNPFALLAGLSLRAWLFFLVGLAAWTADAFDFHALSVQTVKLARHFDRSKTDVSVAITLTLLLRSVGAVFFGLAGDGWGRKWPMVVNMLVLGALQVATIYCASYAQFLAVRSLFGLFMGGVYGNAVAMALEQCPSDARGLLSGILQQGYSIGYILAAGSNLGVGGGVDSWKTVFWIGAGFSIAVGLIRILLPESQQPRQANSQSPAMDFWHSTKAMLRREWKMSIYCILLMTCLNFYSHATQDSYTTFMLTQKQLDNSGASRASMLMKTGACVGGFILGHVSQAVGRRRTMVVGALASGLMIPAWILPEGERALSATGFMMQFFVQGAWGVIPIHLNELSPTSFRSTFPGVVYQLGNMLASPAAQIVNAVAERTHIKVAVGGDEAEVEAYGPVMGVVAAIVVVGILVIVALGPERHGRSLGEHVHVQEEEEETVTGQDKTGGVVAMTQQLEGLKRDARGSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5I5</accession>
    <name>A0A367L5I5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_3973</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5I5"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI09696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="108" mass="12010" checksum="12DBE1A63DAFA482" modified="2018-11-07" version="1">MRGPSLFPLGPQRQSQTEDADRWPILYGLHQVPDSVMSSLPSLHYFSALLILPSGSCRDRDSLLQGPSQSVAVQGQSLSYRLFVLVLDIFLDAKLSEPLCSRWTLAVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5M2</accession>
    <name>A0A367L5M2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5M2"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="214" mass="23705" checksum="DF66A31AEEF766AB" modified="2018-11-07" version="1">MQTTSMTQTVVTQNSDAAACSFLHAPRPVICRAWWRLDSLTLPSSAKSVEIEEQLRERQIEEEEEAEERDEKRQEPKPRQEQPANILRRVREIVLAIPNCAGGEKGSVGTKRFLVRHVPPPRRAERRRPEPASESKSSISGSCRLDEWGASHLDAPSLGSAKREPGLAEDAPMPSLVAVLPPSSHRCRRLADDVGRDHLDVTAAISIARTVPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5Q3</accession>
    <name>A0A367L5Q3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_4051</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5Q3"/>
    <dbReference type="STRING" id="1330021.A0A367L5Q3"/>
    <dbReference type="OrthoDB" id="5278208at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="154"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI09766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="736" mass="83166" checksum="F1E1BC0C468242BD" modified="2018-11-07" version="1">MVLSPSNSPECLSSLTPYQTSVETNKGVRQKNRTAFDNNNIKTLLLPSLPIEDDCHIWTLPQTHQSTPPGDSGLSPSHSVVAVSNLRHWPKGISSGSSVEMGFSVPICGGTTASFHGPVFVDDPRASSNGPRKLVSGFVHNGSDMVKYRRTRSGCFTCRGRRVKCDETHPVCERCKKGNRSCVYPDAPTLKGPLNQKKTKDAAAVVATSETDELKQETRLQDHRFEEEPPDKHLLFTCSNGKERTASCPTRKPSTMATRAVKTKTSLLLRQEWAHLPLDFQHHLAYFVANITNHHYSIANDGDGFFSAILPSMAVQHEPLLHAVVGFSAYHATLQKPDGQLQDFLRYYHGGVTRLLESLQRKEANNVPVLVTILQLATMEEFLGDWVNLMRHQKAALEIITHIFEPATVMDTAVGRMCLNWYSRYDNYVAIMGGFPTGLSREWFDVTMQYCQSRVEAQPESLRWKIDYRSARLRLITFDMSMLYARGSRGQLPPQAFAREHTRLTHELHDWKRSWDPSLTDPTYLITDLSYRRDPGPEDIVDAYKAGTLFHPPLFTTTLITAEWHSIVIMHLSQAAKTPPPPLLAKVREHAYAACQFFEAVERWPACPPGALVSLQPCISIAALFLPHDGKHQMWLRRKFALLDTLGFIHPTTRRLKMARLFRDPSCSRWWLPNDEGLTPVLQSIRAFADERNAAAVDDKLDNIREVRHLFVKLSLEEDKEETGNKDGLAERQINR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5Q9</accession>
    <name>A0A367L5Q9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Putative transcription factor kapC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_4133</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Putative transcription factor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the bZIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5Q9"/>
    <dbReference type="STRING" id="1330021.A0A367L5Q9"/>
    <dbReference type="OrthoDB" id="2593073at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF11">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="10">
        <location>
            <begin position="173"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="39"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="132"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="236"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="283"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="44"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="299"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="312"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI09759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="324" mass="33687" checksum="54E386C99A51C057" modified="2018-11-07" version="1">MQQTTGAGNQEQQLRAQLELLQHHEAAAAAAAAAAAAAAAAVSTPGSTDSRTAASHSPPSRPANGFDELAAASRDAARAIQIKSETEAHIHPDLRGPTAAHAAPTPNMMPMTAAAAVAAAAAAGAGAGAGAVAQSPATTSSPSPNTAIAPAPAPQTPDQGDGRKAKRELSQSKRAAQNRAAQRAFRQRKEGYIKKLEQQVREYNDMEQTYKAMQSENYALREYVIHLQSRLIDLQGEFPQPPPNINLSQPSAPLPPAPEQQAAAANPGVGTPLEAVAQAVAGLAAQEQMTDSQPPYPSRAEEDTRTAEEINRQLQSEEGATRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5Y5</accession>
    <name>A0A367L5Y5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">6-phosphogluconolactonase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_3815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5Y5"/>
    <dbReference type="STRING" id="1330021.A0A367L5Y5"/>
    <dbReference type="OrthoDB" id="9972196at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050282">
        <property type="entry name" value="Cycloisomerase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344:SF1">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016644823" description="6-phosphogluconolactonase" evidence="2">
        <location>
            <begin position="23"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI09846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="403" mass="42878" checksum="C81BC3F6DC849150" modified="2018-11-07" version="1">MFGPSARYGLVWTALWATVSMGQFLYVSSYDGKVTTLDLGSLSGCVSEAGDAEPVELKTVGTTADCGENPSILHLDDDRSIVYCINEGFSGKGGVAALSIDEKTGFLGSGTLKEGDPGPVFGGLFNGGQRLAVANFGNASISVWDVSNPKQLRITQTERFKLDKPGAIADKQNQAKPHQTLIDPTGKFAVVPDLGADLIRKFAIENDKFKPIGQVEVKAGSGPRHAAFAQPRKGRVRMVLVNELDPRVDLFDVVYGAEGGLDLNLVASVPVHGEGKKAAKEAFPAEVVISPDNKFVIVSSRNENNLKIADFKNGTDIPSDPIISFKLDDDDGGKLVFAQEVPAGGRFPRHFSMSGDGTLLAVGLQKDKRVVIIRRDAKDGTLGTRPVAFADVTGEVTSVIFGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L690</accession>
    <name>A0A367L690_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI09940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L690"/>
    <dbReference type="OrthoDB" id="5418627at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="305"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="612" mass="66037" checksum="DB25020BB89240FE" modified="2018-11-07" version="1">MDEAPLVEALRRKLDGLERSLENCRLRLLADFQQDCRFLLRDVPPDTAAQVRRAIAAVFANYPALRPELAAAESPPAAAFQPSPAVSGSPRERELELQGLFTPTYLPLLDSSPASCLAAPNLISPSPLERRVQGAAQEGMEEPMPSSSRPFVLPTPAADDATSSASSTTSDKSDSKPPRSALRRSPTMAKPPQSPRRVRFEFMGAEVLPTTSPQPSELVTRRPSSPKVDRGDDDDDGENGDDDTTAFVSNLAGDTTEEEPTIPRKVSSSDALRALSRTPLEEGVVWTVVNADTDDSAVTQDGKDATSPPSAASEAESPVASLNVGAPKIIAPESTDHGDSDSDADSDSGFLAMAGAKSHRNRPLQAPVSVTGPSFSPSPDDGARPATPTNKQLSSAHVVEEAGRALSRDDVEVEDDEDVFHFETAGLSMSSKSGRRSSWREEKATQPEPDDDGSDATSVQVSDGQFGIYATSPAVPIRQPRKSRSSDPSVKFRPGSVGSYKGQPLMMPIVRDPEVLERALSNDSPVVRECDLDDRTAMEEGSPPRFPSTPFSFSERFMMEEAMERMKSNKDEEWFEEGWDVEMGSITPVNGSLCMANLRFTRGLVFGVIWEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L693</accession>
    <name>A0A367L693_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_8434</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI09941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L693"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI09941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="164" mass="17864" checksum="05130048EE38F058" modified="2018-11-07" version="1">MYNVVVQCQPSLSLSLSLSVREEGGGLIAAAELRNASFTLFLPIVYPLAELAAPQSETSSSSRFPCFKAPIPAGPYQSHPPIHPSIDDGKPPPPFLPLHFAEAKPIQPKEKKEALSPLERQPPAGRIHTMKKELVHWLVASAIDQTIILLVRPCGLHRCSLHPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6E2</accession>
    <name>A0A367L6E2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4038</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6E2"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="212" mass="24371" checksum="94AA939539FFCB25" modified="2018-11-07" version="1" fragment="single">RATSGFGLAHTRRRTGTELEPDSDDDKFTVHCPPCAGRSLPASLRAAAHRERQFNARNGKCPLASPPFWSASMSHRLIRRPLHLHLVRPTGEQTGLALRNNDGRRSEFMQYQYHALDHPQRIIYTAPTPSSHSRKLSAEMPRLITFTETLCDKQRVEMFPICFLALKALMDGPETPSRSIPPVFIFRDTFPRTQGLIRWYWYRIELEQSIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6R6</accession>
    <name>A0A367L6R6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Halotolerance protein 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_8477</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6R6"/>
    <dbReference type="STRING" id="1330021.A0A367L6R6"/>
    <dbReference type="OrthoDB" id="6513151at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13994">
        <property type="entry name" value="STKc_HAL4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000183">
        <property type="entry name" value="Serine/threonine-protein kinase hal4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343:SF558">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343">
        <property type="entry name" value="SERINE/THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="210"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="39"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="138"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00078109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI10098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="493" mass="54438" checksum="0ECF91BD429232CB" modified="2018-11-07" version="1">MPVADSKTPSAPSSKPSSVNSLDGKKSPALSPQDAAAPHPLPPPPPPPDPAADTSQGSHARPSEKSSVKERLTRMFSSKEAPRLEPTGRPRGSSLNGSSSPGPRTKETADKPPLSSSKLATGKDTGSQRFVLGPDLPGGHEHTLRSSRRQEKLSDMWRNLLGKKQDAAAAENDLSLVSNWVDSLRQEKDEGDRKASGGPSVTSTLVEKYGKCQEVVGRGAFGIVRISHKKLGGSGEKLFAVKEFRRRPEETEKKYSKRLTAEFCISSSLRHPNVIHTLDLLKDAKGDYCEVMEFCAGGDLYTLVLSSGKLEVQEADCFFKQMMRGVEYLHEMGVAHRDLKPENLLLTTRGALKITDFGNGECFRMAWEKDAHMVSGLCGSAPYIAPEEYTDKEFDARAVDVWACGVIYMAMRTGRHLWRVAKKDDDEFYARYLEGRRDEEGYAPIESLHRARCRNVIYSVLDPHPTRRLTAAQVLKSEWVREIKLCKAGEEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L755</accession>
    <name>A0A367L755_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_8709</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L755"/>
    <dbReference type="STRING" id="1330021.A0A367L755"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01846">
        <property type="entry name" value="fatty_acyltransferase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051058">
        <property type="entry name" value="GDSL_Est/Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648">
        <property type="entry name" value="GDSL LIPASE/ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648:SF22">
        <property type="entry name" value="GDSL LIPASE_ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016926712" description="SGNH hydrolase-type esterase domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI10251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="31655" checksum="9CE17C798E601CE6" modified="2018-11-07" version="1">MALALFYFSLAIILASGLAAPVGYKAPYSSMIVFGDSLSDNGLTYEVTNHTWPKDPAYYKGRFSNGPTWAEDVAATLDVPLYDYARGGATTDNALVQGFTGSKSDIAVPSLTDQVHDFLSKPRPDLSTSLVVLLGGANDVYFNNTANPAAAAAAIGRLLIQLRDAGATHFLLPEYPDLSLAPYGSSLDDQHKAMLSTYTKQLGADLQRVARNVSSASPGVTIKVVDLQPLFRTIESNSRALGFDRKGLRQACLVGAYGEASRSLCSDPDRYVYFDAYHPTGKTHCLIANEVVDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L791</accession>
    <name>A0A367L791_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Velvet domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_8578</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L791"/>
    <dbReference type="STRING" id="1330021.A0A367L791"/>
    <dbReference type="OrthoDB" id="3056235at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF18">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="6">
        <location>
            <begin position="49"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI10278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="333" mass="36518" checksum="F725DE3794CA1D4C" modified="2018-11-07" version="1">MAGNPGGFLDLPFLQPGRHHPAAGLHYLAGGELPLPVEEPASQQTESYGDPQRQLTLRQAPMHARVAIGKEKDRKPIDPPPIVQLLDKRHNGKSGLYDSPYLFMTSSLVPETYGESPSGKDQELPTNYLVGSLVSSIHRLRDTDNVEGGFFVFGDLSVKREGRFRLRFTLFERDQHSSSFYFVSELVTNAFTVYSTKLFPGMADSTQLTRTFSNQGVKVRLRKDSSGMAARKRNRGVADVTDDFLDRQTKRSSYDRELPIGNYAVSDMGHMDGGLQHSSIVVSSAPPPLTGGHYLVAGTDHLPSPSSSSSRNAGLGGMPLPTSGYYFTGAQYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L860</accession>
    <name>A0A367L860_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L860"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="109" mass="12185" checksum="063C2633BC7895AA" modified="2018-11-07" version="1">MRRSCDPSQVESSHVKPRASSILGSLNRWVSPYLAAIRIEVRIYSAAISGQHVNPILPRSDSSIRIPMLRSFSLHYPPPLPAQIYTRPVSLRRIIAATARFVSSFPTLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8B6</accession>
    <name>A0A367L8B6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_4470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8B6"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI10472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="326" mass="36883" checksum="6B018EFF2FDDE7C6" modified="2018-11-07" version="1">MMMSNQGVDHVIEKKKTNHVMVVLSDEVEADNKLEVVLYYSTMTWLYVIPFHFNVMDQPDDLTLVRPSRSGAITAIGTARRSLTARRSMYSAPIAVTIAVTSRFGRYDRYSPTVTQGVVAGLRPNWKNVGKKWVCLLKSVGKVESNEVFCGAVEEEEGGEKLVEMEMIMSNQGVDHVIEKKKTNYVMVVFNEVEADDKLEVGRKTSFLYRQISQQQRYLTWKIGDLEEDFNVMDQPDDLTLVRPSRSGAMTAIGTARRSLTARRSMYSAPIAVTIAVTSRFGRYDRYSPTVTQGVVAGLRPNWYNLFQVALQAYFLSVQDEKICVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8G1</accession>
    <name>A0A367L8G1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein uL23 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_5327</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8G1"/>
    <dbReference type="STRING" id="1330021.A0A367L8G1"/>
    <dbReference type="OrthoDB" id="1267328at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000035">
        <property type="entry name" value="60S ribosomal protein L23a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_A">
        <property type="entry name" value="Ribosomal_uL23_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_uL23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005633">
        <property type="entry name" value="Ribosomal_uL23_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011118">
        <property type="entry name" value="PRK14548.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L23A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03939">
        <property type="entry name" value="Ribosomal_L23eN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL23 N-terminal" evidence="7">
        <location>
            <begin position="23"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI10706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="162" mass="17773" checksum="0A95DB47F057FB1F" modified="2018-11-07" version="1">MAAGKEPTTKGKKAASSKGSKGSKQANAAAKAALKGSHSQKQRKVRLSTSFHRPKTLVLSRSPKYPRKSVPHLPRLDEHKIVIHPLNTESAMKKMEENNTLVFIVDIKANKAQIKQALKKLYDIDTVKINTLIRPDGSKKAYARLTPDVDALDIAANKLSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8I8</accession>
    <name>A0A367L8I8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5179</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8I8"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI10743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="53" mass="6074" checksum="47D79914B5ED27C6" modified="2018-11-07" version="1" fragment="single">MPNSSYWPKRNYYSTILLESLSGLTTSPSSLSTPSRSFCPRRLYLIGRSTRPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L900</accession>
    <name>A0A367L900_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L900"/>
    <dbReference type="OrthoDB" id="5264002at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="116" mass="13155" checksum="248ABFDD92D6FD59" modified="2018-11-07" version="1" fragment="single">PPVISFLSKVFNFTNLFSKEKASALPPYYSSYNYYIRLRYNPDIYMPEAALTPPKIEGGLGANRTGSAPRNCNSDGDSDVIEVPAKRQRLEVVVEEERVLRFYSFLTQLILDRGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAE4</accession>
    <name>A0A367LAE4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA-splicing endonuclease subunit Sen54 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_7129</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEN54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAE4"/>
    <dbReference type="STRING" id="1330021.A0A367LAE4"/>
    <dbReference type="OrthoDB" id="408683at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024337">
        <property type="entry name" value="tRNA_splic_suSen54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024336">
        <property type="entry name" value="tRNA_splic_suSen54_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21027">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21027:SF1">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12928">
        <property type="entry name" value="tRNA_int_end_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA-splicing endonuclease subunit Sen54 N-terminal" evidence="4">
        <location>
            <begin position="76"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="438"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="49"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="446"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI11391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="484" mass="54282" checksum="9C58DB7A5325FF37" modified="2018-11-07" version="1">MAFDDDEATPASNIAVMEDDDAAAEDGLPDYQLFASMLNKKNVSSKSIRKGEKDFESHGTRSQEDTLEASRQALENVLAYTRTHRPDSWVRGWYFPDWWSDKSSDDGRDPFLRHRVVVVEHERGGWMKDIGRTATGTNRDEPGIGRLWLLPEEALYLVERGTLDLWWPDLPLSELLPNDKQAAVEARERFVIDNFDVGLPLTLEAAYALLVGYDDEPGRTSLPKFQVYSHLKRAGFRILRAPSAQALPATTTDVCARPTPPSLWQWLVSLFGRNADARPKLRTVGPLVTPGLYRTYTDIYRQLELVPRHRPNAAMQEQQQQQQQHGTPPQEPFRVHFHVWKSGGLPFSKKKPPPPDFRIAVTDTAGSGLPTLSQLDALFGSVPPDRPGENMQGPGRLYQRIRHGYRNVIVAVVDWGLVNFMRFGEAAFGEEKLFERFDGRGQNSRGGRRGGRGGGRGRGRGRGGGGGKAGRGGERGGWKCYQWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAJ1</accession>
    <name>A0A367LAJ1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAJ1"/>
    <dbReference type="STRING" id="1330021.A0A367LAJ1"/>
    <dbReference type="OrthoDB" id="28868at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.390">
        <property type="entry name" value="Hemimethylated DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011722">
        <property type="entry name" value="Hemimethylated_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036623">
        <property type="entry name" value="Hemimethylated_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032698">
        <property type="entry name" value="SirB1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31350:SF27">
        <property type="entry name" value="HEMIMETHYLATED DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31350">
        <property type="entry name" value="SI:DKEY-261L7.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13369">
        <property type="entry name" value="Transglut_core2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08755">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00992">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141255">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="630" mass="72220" checksum="58951DEB7FF06F0B" modified="2018-11-07" version="1">MSLEKVPDEIIQHLLYYISPADNLENLQYLSRRFNRLANEPLLWRYHCSSSFRFWHQHHEYRRKLRRKASEVDWKQLHIQRTRQNRIVMENLDSIIATKVGRLKRFEQVARLGYDAKDFLLTQCRTDESADDYLARRYYSHALLGSIHRSIAIEEWHQLRQDRDSLDVQVAGVRLERALGAFDMFVLYDQPGDLDDVSRLNDVPFQGASNANALPIRQISQMLDDKAAEFRACHPNLDELTTRLKALALNRWLRANGLTGMCDPKHNYLNLRNLLIGQALRHEDHESGHIISSAIFCCLAARIGLTAQCCAFPGHVHAIVFAPPGWTLDGATDCGETPESLYLNPYGSDDEVPAACFQALLARLGWHNSPDDFFAPVPTALVALHTARNIRSTFAHLIETQHDDDEPYRLSQLICGNSAVNMEAALYSSGWAPLMLEPPNTFEWDDSLANFLRRNVGSWPEDIWLIDKYLWPLYVSSTPLRDSLARHRNHGLDDPWEHLRQIRDHDEKVPLVQARTALRGSDCVPYKIGQVFRHRRYEWIGVITGWTDKASRSHPASHADERPTGGQFYFMCFPSTGSEPHVLGAETIDIITDASQVGDDMFPLAGKFFKRFDRASCTFVSNIREQYPDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAK0</accession>
    <name>A0A367LAK0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7222</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAK0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="130" mass="14434" checksum="1818C511FF6A01D3" modified="2018-11-07" version="1" fragment="single">MSGSEWGGGNVLYFMQPERQASHHFVHVASALALPSSRKAEQLNAKGKKIRNPSWTTTSVYRRTDTNTNQTKPTHNGVGEEERRASSCLFLSCRETICKPPTHLQCNASEANRIRTDGRSLSTLVYSVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAS4</accession>
    <name>A0A367LAS4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Erythromycin biosynthesis protein CIII-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_7712</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAS4"/>
    <dbReference type="STRING" id="1330021.A0A367LAS4"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016758">
        <property type="term" value="F:hexosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008194">
        <property type="term" value="F:UDP-glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF13">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Erythromycin biosynthesis protein CIII-like C-terminal" evidence="2">
        <location>
            <begin position="381"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI11516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="512" mass="56256" checksum="CC4F7E690DC0453E" modified="2018-11-07" version="1">MPRDAGKASDNEKRRSNDSNNRKILLLTNSELGEANVFLALSPALLQADPDVEVHLASFASLKQHVDQVNANFVEQALPSIIFHEIQGSSMLDSETEISFFNTEALKTPLRFSTSIQALNGMVPMLVPYHGPQLVRIVKSLIDIIRQLEPDVVVVNSLMTAGLTACYHLQVKFACLSPNSIKAFAGRSQPWLRTMWKHPAPFSGYSYPVPLHLIPLNVCFLVYLIYIWRTDARRREVAAHLQAETGAVLRTALDLLQNRPPGLKILVSSYPELDIPLVVPPFVHPCGPIVRCSRAVADADPKLLTWLARGPTIYVNLGSLVWFDAEQTTEMAQALRLVVDTLEKGAYPGIQLLWKLKADKACKAELETLARSLLNSQAKDGRVKIVDWIQAEPLSVLKSGHVVCSVNHGGASSFNEAIVAGVPQIILPVWTDCHDNAIVVEMLGVGRHGSKATKPKWTAPELSSQLLAVLDGEPAEEMRRKAKELSTLCASRGDGAEHAARILLEDLSQARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAX4</accession>
    <name>A0A367LAX4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAX4"/>
    <dbReference type="STRING" id="1330021.A0A367LAX4"/>
    <dbReference type="OrthoDB" id="5431245at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037738">
        <property type="entry name" value="Ecm13-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36826">
        <property type="entry name" value="PROTEIN ECM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36826:SF1">
        <property type="entry name" value="PROTEIN ECM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="228" mass="25568" checksum="27C6A101E2483473" modified="2018-11-07" version="1">MSITQTYQLAHTARAKLSFEASQQDHHLRLLVGHANMLDSLMLELADVEREQEQWFNQSVRGAASSSCHSQPARRIQWADRVLVEDYESSMDDDESDEDDSDDDFDEADFEMTVSSSTSPCSMRVPLTLDKGDDDDDDDDGLRDDLEDDYALLELVRTPSRSNSPPELIDPDSDTSDDDVMPPSPADDDLPFAIDKEESATDDDLYPQDYYVSRPSPSGRLVSAISVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LB62</accession>
    <name>A0A367LB62_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7728</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LB62"/>
    <dbReference type="OrthoDB" id="4923568at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="176" mass="17806" checksum="9AF0415730779CB7" modified="2018-11-07" version="1">MSRQKLAMTAGAGALAIGLFYRHQSKAAKKQDENPSRHGAHAKRDLGLQGAAVGGNAVVGSADLNARRNRQPSRSPAPLEKLPSGGTGGGEGAGGSSARRTQFPCSSSGQSFGGEKKVNSSNTPSQGPGALEALRGVFSPGGEDGVNPVDEGGFRDTRGASKMGSELPSKKRAPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBF2</accession>
    <name>A0A367LBF2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP phosphoribosyltransferase</fullName>
            <ecNumber evidence="5">2.4.2.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L249_7387</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>1-(5-phospho-beta-D-ribosyl)-ATP + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + ATP</text>
            <dbReference type="Rhea" id="RHEA:18473"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:73183"/>
            <dbReference type="EC" id="2.4.2.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP phosphoribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.17" evidence="5"/>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBF2"/>
    <dbReference type="STRING" id="1330021.A0A367LBF2"/>
    <dbReference type="OrthoDB" id="2574at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003879">
        <property type="term" value="F:ATP phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.120:FF:000003">
        <property type="entry name" value="ATP phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000082">
        <property type="entry name" value="ATP phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000123">
        <property type="entry name" value="HIS1p ATP phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00079">
        <property type="entry name" value="HisG_Long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020621">
        <property type="entry name" value="ATP-PRT_HisG_long"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013820">
        <property type="entry name" value="ATP_PRibTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018198">
        <property type="entry name" value="ATP_PRibTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001348">
        <property type="entry name" value="ATP_PRibTrfase_HisG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013115">
        <property type="entry name" value="HisG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00070">
        <property type="entry name" value="hisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03455">
        <property type="entry name" value="HisG_C-term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403:SF8">
        <property type="entry name" value="ATP PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21403">
        <property type="entry name" value="ATP PHOSPHORIBOSYLTRANSFERASE ATP-PRTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01634">
        <property type="entry name" value="HisG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08029">
        <property type="entry name" value="HisG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="GlnB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01316">
        <property type="entry name" value="ATP_P_PHORIBOSYLTR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP phosphoribosyltransferase catalytic" evidence="14">
        <location>
            <begin position="59"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine biosynthesis HisG C-terminal" evidence="15">
        <location>
            <begin position="245"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCI11768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="319" mass="34279" checksum="1768C7E5DB32D672" modified="2018-11-07" version="1">MHENYSLENRLLFAVPKKGRLNQASLNLLEGADIQFRREHRLDIALVKNLPIALIFLPAADIPTFVGQGRVDLGITGWDQVKEHEAAVLADNMVSSDCSSSGCEMVMDLGFGGCRLQVQVPEKGKYTTSQDLIGGTIGTSFVNLAADYFANLESEAADDRPSDGTSLKLRTKIIELSGSVEAACALGVADGIVDLVESGETMRAAGLKSIDTVIDSMAVLIKSGAPSDPAMIELITSRIRGVITAQKYVLCQYNIERSRLAVATNITPGKRAATITTLDTDGWVAVSSMVEKSKIALVMDELSRVGARDILVLNIHNTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCG9</accession>
    <name>A0A367LCG9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Required for respiratory growth protein 9, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_4224</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for respiratory activity and maintenance and expression of the mitochondrial genome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RRG9 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000009">
        <property type="protein sequence ID" value="RCI11922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCG9"/>
    <dbReference type="STRING" id="1330021.A0A367LCG9"/>
    <dbReference type="OrthoDB" id="5578174at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010487">
        <property type="entry name" value="NGRN/Rrg9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13475">
        <property type="entry name" value="NEUGRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13475:SF3">
        <property type="entry name" value="NEUGRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06413">
        <property type="entry name" value="Neugrin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="254"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="283"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="330"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI11922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="518" mass="59711" checksum="845CC2BC2BD59091" modified="2018-11-07" version="1" fragment="single">CEDRTEACGKALHANYDRDELDVRNKDPLATARKLLFQAQYFNDTAVKWLLSSNVHNFVYANATTWQAFYNTSDWMKPTRNHLREVLESIPVIVYAGDADFICNWLGNRIMTDELAWPGHDAFNNAETRSLRLAGAEGSVYGTIKAARNLAFGRIYDAGHIVPMTQPQAYLDLLNRWTRGEWFENRLVSPKVAMSCVCGSLPWRFFVQGLIRVHRLDSSRFRGTVRAIPWPVETPFQQRAFRLLQGPRLYKASGLTKNEQQISSATETPSTSPTTPSAAISKSPDRRRENLRQSTDKKYSFMKKDEDQRNGSPSSRPTDSATPPPPPPKSKKDFGTDKPKTTDDSSRERDGTAPQFEKRKKERWMIQKEALKAKFPEGWKPRKRLSPDALTGIRALHAQFPDIYTTPALADRFKVSVEAIRRILKSNFRPNEEQEEARRERWERRGLQVWERKAALGIKPPRKWREMGAVRDPSHHDRAMRSSKWEKQLEEEEIRAYQKQYLERRAREQKGSGETSGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCU7</accession>
    <name>A0A367LCU7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_1057</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCU7"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI12052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="94" mass="10920" checksum="8B688DDB5E1F3DF0" modified="2018-11-07" version="1" fragment="single">KAPRKRLSSRQLTFIIDLTLNFGRIRVNYKAFTDKVVIIEKQPAFSSTYCLKIEPKFKVLNEVKELLNLLAARIRVLGRKKEDINKARLKVAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCV6</accession>
    <name>A0A367LCV6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_0005</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCV6"/>
    <dbReference type="STRING" id="1330021.A0A367LCV6"/>
    <dbReference type="OrthoDB" id="39734at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051701">
        <property type="entry name" value="Mito_OM_Translocase_MSP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644:SF56">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45644">
        <property type="entry name" value="AAA ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12920)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="726"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="40"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="640"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="982"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="986"/>
            <end position="995"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI12268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1021" mass="113907" checksum="C8D69E0A352B6609" modified="2018-11-07" version="1">MFAATAFLSPCHAAPYIPRLPSVVACRAFHFSVCRRRNEGAGGKPIEDSVTEQDGDAGSHIGTEMLGGRVRGQTTGSYKYRQSRKHVTSALPPVQLPKSFLEQRVTLYSPRRPPTLPRALAEDLHHEKVSRLYSAGTEASTSQKTYQSLEKYFSMALTSLQKQHDEMLHDILTADQQCHQSPGAFDQLLERLLRLNDMIIDASWHLVDSLYPCRQAEYVYKVRPFWWWDIYDDPDCPARKFRDQHPDTSTPTLLHFKTDPTLEYPPSHALADLPIDALVHLMRTFINDLGMPPPPNLDSKTIKRPITVLSLSGYGGQAIAEAVGKHIAYDVSADLIQVDAYDLSTLVGDYLGQNWAYSRGAVSMMGFRAAELNGKLVADPEPPGKQESAEDADSEPIVNGIRASYSSTLDEELQKIKHGTSACFTRWENLKIEKILDHIIRSADLKRSSPNPRPVIIHVHDIVELSMTLEGSLIINKIRALVDSAWQQGTHIAFLGTSSCEQPSDEYQSAIRELAVGDLVITRRIQPDRADKHVSKTSGVPTFNLQKADYIAENLANTKRMLGAIHPDLSLQYLEQSLDALKEFYLATKSFDATSRGPILPIPQIYQIATAIKTFDSRGNFARFPAFARHLANSPLREKQVHNSLDEQLPKEKAENAEKSTVEARQIKVNEYEKRISTGQIDPWTIQTTFADIHAPAETISTLKLLTTLALVRPDAFSYGVLAQDRIPGCLLYGPPGTGKTMLAKAVAKESGAKMLEISGASINDKWVGESEKLIRAIFTLAKRISPCVVFIDEADSLLASRGASVHRAARREHINQFLKEWDGMEKTTAFIMVATNRPLDLDEAVLRRLPRRILVDLPTRDDRTAILRLLLRGEMLDESISIDEYADRTTFYSGSDLKNMCVAAAMAAVEEENEAATKHKGPEPFRYPERRILRKAHFEKAIEQIPASISEDMDSLKMIRKFDREYGNANKGAKKKKVIGFGDLGHGRLDDIGVRRSSQTGEGEQFPQLAPAGVARPTRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEF8</accession>
    <name>A0A367LEF8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_0098</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEF8"/>
    <dbReference type="STRING" id="1330021.A0A367LEF8"/>
    <dbReference type="OrthoDB" id="5784at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070916">
        <property type="term" value="C:inositol phosphoceramide synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006676">
        <property type="term" value="P:mannosyl diphosphorylinositol ceramide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03386">
        <property type="entry name" value="PAP2_Aur1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.144.10:FF:000015">
        <property type="entry name" value="Aureobasidin resistance protein Aur1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026841">
        <property type="entry name" value="Aur1/Ipt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052185">
        <property type="entry name" value="IPC_Synthase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31310:SF11">
        <property type="entry name" value="INOSITOL PHOSPHORYLCERAMIDE SYNTHASE CATALYTIC SUBUNIT AUR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14378">
        <property type="entry name" value="PAP2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="211"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="401"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="404"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI12796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="459" mass="51197" checksum="F3EA12E1DEC127B6" modified="2018-11-07" version="1">MDCPGSPPRKPVLPTLWTENLTDVVLGRLPRRSQSGRRRSRSDVKASRYRAPDITSLQRSFSLWDGVRDLQRRRWRPADLQYLFLAALTLFSLAIAPPAPILKASALAAAAWLLLMPATRQFFLPSVTIWVWLVYFFCSRFIPYDYRPHIWVRVLPALENVLYGANLSNILSAHQHAVLDILAWMPYGIIHFGAPATCSLLMFIFAAPGTTSVFARTFGWMSLLGVTIQLLFPCTPPWYENEHGLVPATYGMPGSPAGLARIDAIFGIDLYTTNFTAAPLPFGAFPSLHGGYAVLEALFMSHCFPNFRIFFISYAGWIWWSTMYLSHHYAIDLVGGGLIAMAFFYSARARWLPRRQPDKSTRWDYDYVEIGTRSRPADEEYGVGVGAGRQYIGLGLLQHRRPSSSDGWTVGSSSSYSSSSGTISPTSSDSSSGVFADVDQNSPWDSDSDLPLHQVSLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LET8</accession>
    <name>A0A367LET8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dihydrodipicolinate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_1321</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DapA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LET8"/>
    <dbReference type="STRING" id="1330021.A0A367LET8"/>
    <dbReference type="OrthoDB" id="191315at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF52">
        <property type="entry name" value="4-HYDROXY-2-OXOGLUTARATE ALDOLASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001365">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="2">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR001365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001365-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI12944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="34127" checksum="647AC8A8DFBAAADF" modified="2018-11-07" version="1">MPPPKIDKLRPGIYVPTVAFFTAPDQDKIDVDATKAHVRRLVQAAVAGVVVQGSSGEAVHLDRQERNAVTRATRCALDGTAVALVAGCGAQSTRETVTLCRDAAESGADFALVLPPSYYHAAGGLTMDLVVRHFRRVADESPLPVLVYNFPAVCSGLDLDSDVLSSLARHPNIVGVKLTCGNTGKLARVVASTAADDGFRVFGGSADFTLQTLSVGGHGVIAGLANVAPAACVEVMRLWQEGKVDDAVRIQAVVATADWVVINGGFVSVKAALETYFRYGGLPRMPCRLLEGDALDAQMAGLVELVELERKLAVYSSSSSLLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEU4</accession>
    <name>A0A367LEU4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Proteasome alpha-type subunits domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_0936</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEU4"/>
    <dbReference type="STRING" id="1330021.A0A367LEU4"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03754">
        <property type="entry name" value="proteasome_alpha_type_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000026">
        <property type="entry name" value="Proteasome subunit alpha type-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034642">
        <property type="entry name" value="Proteasome_subunit_alpha6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI12937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="253" mass="27689" checksum="B6DEB69C150D655D" modified="2018-11-07" version="1">MSAGAYDRHITIFADNGRLYQVEYAFKAITAANIMSVGVRGKDCAVVLSQKKVPDKLIDPSSVSYIFQISPSVGCVITGSIADARAFAERAQGEAAQFRYKFGYEMPADVLAKRLANISQVYTQRAYMRPYGVATTIIALDSELGPQLFKCDPAGYYIGYKGTAAGPKQQEALNHLEKKLRNKDHAEGTWEDVVELAITTLSTVLSMDFKKGEVEIGIVGGPRKDGAEGTDPSFRMLTEDEIDDRLQAIAEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFF4</accession>
    <name>A0A367LFF4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial phosphate carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_0641</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFF4"/>
    <dbReference type="STRING" id="1330021.A0A367LFF4"/>
    <dbReference type="OrthoDB" id="427452at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF15">
        <property type="entry name" value="MIR1-PHOSPHATE TRANSPORTER OF THE MITOCHONDRIAL CARRIER (MCF) FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="15"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="115"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI13156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="33333" checksum="C2A6B04DA7254B00" modified="2018-11-07" version="1">MAKSDDDDVPSFTAGDYAKFFGAGALAATVTHGAVTPIDVVKTRIQVDGHLKGYGMMSAGRSIVAKEGASALLTGFGPTAAGYLVQGGAKFAGYEYFKKRYMAAFAGSPSEAVAHRTAIYLTASATAEFFADVLLCPLEATRIRLVSQRGYATGLATAFMRMARQEGLAGFYSGFVPLLFKQVPFAVGQFSVHEAVNELLFRAMGPERKAKLTSMESTAVELTSGLAAGAAAAILSHPADTLLSAINKGAAGGGGKGRGPTARMVQLAREFGLKSLLLTGLGPRLVMTCGLVSSQFVIYSRCKALTGAPPSIEIHKESAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFK5</accession>
    <name>A0A367LFK5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1175</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFK5"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="334" mass="36517" checksum="39FE727C6C6657D4" modified="2018-11-07" version="1">MAAAERGKEMEGGWGRAVGQSDVVHPRTHRGLGGDELRRANRRQLQEAVARSILPLANVLCNSDGSSPHRSNPFGWNASCESARAPPPSRKGWTGPEANEGASARSATSLLFNTAESASLFFFFCSITRASWQAFIRSLANPTDYSSLFCQPAQMHGGGNWLAHVYSLLGWSGARHSVSRSALETMAVDAAWRLQETDFGEYRVHYTQLSVHICALVEQSSISALPHQQLLPMSGASRDDLHQYLFESIDCARSVSSPSLPLLRGSDSVMTNRGCFCGPPSHLQTSRRRGRIRDPGLRYPASSEHSSRDLAGPFCVPLQREGRVPGRMGESCFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFR0</accession>
    <name>A0A367LFR0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_0345</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFR0"/>
    <dbReference type="STRING" id="1330021.A0A367LFR0"/>
    <dbReference type="OrthoDB" id="409136at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI13251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="356" mass="40294" checksum="65E19AEE4B563830" modified="2018-11-07" version="1">METDVYPQVQAIIPSLAFFVVKRGVGMGASILSAPAYSLQRDISSACLLPFALRALGTSARAMPSSVVAAEIHDFLRKLERNKGSGLSYQSVNYTPPSYYQASLLMSEPGPSKSVPAASLASSATPRSFVFDSVDGQSVYSASTAPPRQGPEPLHRQRAPVPDFSPTWLPCEFHRLSRCQERFAIEDVDVWIQHIVHDHLEGKLPAYCICWFCDRAEFRAGPDRAENYQRRMHHIASHIRDEGKTAAEVRWDFHFLDHLYHHGLVSERVFQWATQQSELPPPRGMILVQRNQGDGRRRHARPRDPTRPHHMLTLDRCISAKVFQEEEDDDDDKRNREGRRQGALYAGCNRTMFIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFV1</accession>
    <name>A0A367LFV1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_1130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFV1"/>
    <dbReference type="STRING" id="1330021.A0A367LFV1"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI13132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="119" mass="13439" checksum="5C239B2FE2342A57" modified="2018-11-07" version="1" fragment="single">KIRTNKATFRDKEDRIGFLFRSLEGKARKTLETYLLTKTKDDSLSYEDFCGYIKDAAVKRLDAKLVLVSLVPLVDFQGRLASPPNDLPALAKYSLSILLPKTPLLNRQIDPAVQANTER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFX8</accession>
    <name>A0A367LFX8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL15</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">L29</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_0635</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFX8"/>
    <dbReference type="STRING" id="1330021.A0A367LFX8"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L27a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_uL15_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 9" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="8">
        <location>
            <begin position="72"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00080124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI13321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="149" mass="16859" checksum="8919B4DD38340BE3" modified="2018-11-07" version="1">MPTRTSKTRKLRGHVSHGHGRVGKHRKHPGGRGLAGGQHHHRTNMDKYHPGFFGKVGMRYFHKQQNHFWKPVINLDKLWTLVPKETRDAYISGKKKDTAPVLDLLPLGYSKVLGKGRLPEIPLVVRARWVSKLAEKKINEVGGVVELVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LG08</accession>
    <name>A0A367LG08_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_0869</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LG08"/>
    <dbReference type="STRING" id="1330021.A0A367LG08"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016786919" description="FAD-binding PCMH-type domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="112"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI13363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="610" mass="66722" checksum="9B92FB5242243FAA" modified="2018-11-07" version="1">MATTLLALFLCLSTLATARPGPHCKAFPGDSNWPSREAWNGLQGTLQGRLLSPAPPGAVCHGDKPTYDPAQCPNVQRLWTSFEFHAQNPLSVLWNMWTGFDCLPDPKAPCTGRGYPAYVVNASETAHVKLAVDFARKHKVRLVVKNTGYDFLGRSTAPGALSIWTLHIKSIQVHPNGQFKLGGSGRTVRGNAVTVGAGTLAIDIYRALDRHGLTFIGPMGPTVGIAGFLSSGGHSNLSGKYGLGADNVLEMELVTPKGEVVVVNEDVHRDLFWALRGGGGSTFGVVTRITMRTYPTPKLVGFHWVAGIAAQDGQASDLAPHLMSKMPDAIDAGLLGWTAVIDNVPNPVSVPGQDMSGQNVSGIYGVNAVMDTNDPAEAHRVLKPIVDAVKASRWNGRARLWLTTTPYPSYIAYVNGVYSPRPGGYGWYEVSRIMDRKAFSGDTERLARALHAVRSNNRGNMFAMTLAGKGVQDVKLPNSVNPGWRAAYALGMTSLTFKPFDPKAETDARQFLDSAWQPMRDLTPELGSNIDEFLDSVWQPMRDLTPELGSNIDEGFPYEKNWRQAFWGNNYARLLLIKRRVDPDDVLWCSPCVGNERWRQSQDGHLCRIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGK1</accession>
    <name>A0A367LGK1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L249_5474</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGK1"/>
    <dbReference type="STRING" id="1330021.A0A367LGK1"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070985">
        <property type="term" value="C:transcription factor TFIIK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07841">
        <property type="entry name" value="STKc_CDK7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037770">
        <property type="entry name" value="CDK7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF0">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="62"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="349"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="349"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="68"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR637770-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR637770-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCI13563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="408" mass="45419" checksum="AA41EF8BAF625B68" modified="2018-11-07" version="1">MTTSPVVVVTASQEHISSPLKSRQTTVSNHGTPPRPAPTASATVPPSLDLAELMNEDEKRKYAKGKKLGEGTYAIVFLGHLRARPTTLVAIKKIKVQKEYTEGMAPDAVRELKHLQELHHPNIISLLSVFSSKDQNLNLVLEYLPLGDLEMLIRDTDRVRYGAADIKAWMGMLTRAVWFCHENFVLHRDIKPNNLLIAADGEVKLADFGLARSFADAHQNMTANVITRWYRPPELLFGARHYAGAVDIWSVGTVFAELVMRAPYLPGANELDQIKLICEAVGTPSEDNWPGVTTLPEYTVPAQHPVRGRDWYEMRFGTVGPDGVDLLLRTLALDPKRRITARDMLRHPWWHADPKPSRKEDLPRKQQSEKPAGDGKKRPGGVATAGGQEDEDGRGAKVARKLDFGSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGW3</accession>
    <name>A0A367LGW3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5521</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-10" db="EMBL/GenBank/DDBJ databases">
            <title>A genome scan of diversifying selection in the zombie-ant fungus Ophiocordyceps unilateralis complex supports a role of enterotoxins in coevolution and host-specificity.</title>
            <authorList>
                <person name="Kobmoo N."/>
                <person name="Wichadakul D."/>
                <person name="Arnamnart N."/>
                <person name="Rodriguez De La Vega R.C."/>
                <person name="Luangsa-Ard J.-J."/>
                <person name="Giraud T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGW3"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI13492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="45" mass="5098" checksum="DA575FEB0B4E38ED" modified="2018-11-07" version="1">MIYLLTKTKDDSLSYEDFCGYVKDSAVKRLDAELVLVSPVPLVDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHJ7</accession>
    <name>A0A367LHJ7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHJ7"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="129" mass="13812" checksum="EF671F7148F1F579" modified="2018-11-07" version="1">MLFYLIATVYVRCSHPGQDEVNPSLGTTGSSQRHNTGRTSAVLAGPPVRFLHSPLPPSGPPLTPPAPGYISDSDPGPQHVRAETASPDPDTRTMIIIMSFSKMTNLNEAMISIKDDSRDGSKYFAVSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHL2</accession>
    <name>A0A367LHL2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL22</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L17</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_8199</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHL2"/>
    <dbReference type="STRING" id="1330021.A0A367LHL2"/>
    <dbReference type="OrthoDB" id="10254664at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.10:FF:000010">
        <property type="entry name" value="60S ribosomal protein L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018260">
        <property type="entry name" value="Ribosomal_uL22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005721">
        <property type="entry name" value="Ribosomal_uL22_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01038">
        <property type="entry name" value="uL22_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593:SF10">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00464">
        <property type="entry name" value="RIBOSOMAL_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI13900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="188" mass="21060" checksum="6B2A5B6809980560" modified="2018-11-07" version="1">MVRYAATEIQSSKSARARGSYLRVSFKNTRETAQAINGWKLQRALAFLENVKEHKEAVPMRRYAGSTGRCAQGKQFGVSKARWPVKSAQFLLDLLKNAEANADAKGLDTGALVVKHIQVNQAPKQRRRTYRAHGRINPYMSNPCHIELILTEGDEVVQKSEPVAGREQLHLNSRQRGARIRQAIRAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHM4</accession>
    <name>A0A367LHM4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_8144</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHM4"/>
    <dbReference type="STRING" id="1330021.A0A367LHM4"/>
    <dbReference type="OrthoDB" id="2119662at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052031">
        <property type="entry name" value="Membrane_Transporter-Flippase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43549:SF2">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN NORM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43549">
        <property type="entry name" value="MULTIDRUG RESISTANCE PROTEIN YPNP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="348"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI13925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="485" mass="53725" checksum="54BC8321ED0F6524" modified="2018-11-07" version="1">MNGNRETTRNPSPASIRSLGGRKLPGSFNTYTRAFLVNNLSFILPALYSSLVKLWIARIDPAMVATTDVFTYISVIAEVLNEGLPRASWSTIGDSSSDLPRRLRLTHTLILTQSLLGLILSLIIFGNATRFASIFVPDHARRLSIIYVQISSFSALTSALETATATATRALDEPDVPFVFNCVKFAANIVLDMLLISTFRVGSYQPTANLQAGIQLACNLASAFFGLGYFLWRNSSWRRPSTKPAFSAFLVLLRPGLFTFVESAVRNTLYLWLVSTIVSLGSLYATAWGVFNTIRWGLIMVPIHALEATTLTFVGHNWGLWCKDMENSPAGTCQRATIKSLYRITRPAFLSIGIALAYELPIYALISAVGARSFARYLSDDDGVAAVTARMWRTLDWCYILYAVSTQLAAVLLATKPRWFMWQSLASNILYVLPWATVCQVSHLDEHNAWTYHALVFGGSLVFSFICIPLVLAVLAWVLVRRGNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHR0</accession>
    <name>A0A367LHR0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8306</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHR0"/>
    <dbReference type="OrthoDB" id="4928265at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="350"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="469" mass="50911" checksum="EEDF34962CA55F63" modified="2018-11-07" version="1">MSACSDGRGAWSRIRSLSSRRRSKSMPRPSSSTTKDASVNDDAPVVAHLRLPDSAVSGTTIGGFRHIAISIPIEASPFADDLRSQYPHQHHHHQHRLNASLGSKPFDYIGALPSCLDSPPLLDDGSAPWNHRPDDEPTREIISRVVHQPSSSSSSSSPPPPPPSSRQQLLSIDSLIRNNSPLPPPPPRAPERGRLMREPASTTVIVENPVVVSCSSSRSRREIVKERKRRDLAAMRKRSEPVKATSSSSSSSSSSSSSPSSTSSSTSTASTSNISSAEKKKKKNKKNKKKTGSKSCHLTVSAVQVTLDIPPDEGSQSITMPTPPPSITGSPSSPPPSSSSSSPLPPPKLHSQEEEGEKRRETTTTRIAAAATTNAHNNEDDDEGDVYVTYHRDHQMRDMERRLKRLERNGDVWLRRTLLANVRRLDSGGKDTPLNHGCSAAGMESVEVLMRELARTGGVRPLRPPLLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIB3</accession>
    <name>A0A367LIB3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5963</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIB3"/>
    <dbReference type="STRING" id="1330021.A0A367LIB3"/>
    <dbReference type="OrthoDB" id="4509994at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="97" mass="11178" checksum="D2A2A968610AFD4E" modified="2018-11-07" version="1" fragment="single">KIRTNKATFRDEEDRIGFLFRSLEGKARKTLETYLLTKTKDDSLSYEDFCGYIKDLAIKRLDAELFLPNNLPALAKYSLSILLPKTPLLNRQIDPAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIS1</accession>
    <name>A0A367LIS1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_6046</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIS1"/>
    <dbReference type="OrthoDB" id="4927418at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="106" mass="11671" checksum="CAF38FF8BEE78A25" modified="2018-11-07" version="1" fragment="single">YIACGYFPARYKESNIIVLRKAGKSLEVLRTPRGYRPILLLNTLTTLIRSYLTSCSSRLKVDGRLSKPFDIERGAPRGTRPTLLVYLAAGSPLALASESLSLLGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-09-13" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIS4</accession>
    <name>A0A367LIS4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5978</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-10" db="EMBL/GenBank/DDBJ databases">
            <title>A genome scan of diversifying selection in the zombie-ant fungus Ophiocordyceps unilateralis complex supports a role of enterotoxins in coevolution and host-specificity.</title>
            <authorList>
                <person name="Kobmoo N."/>
                <person name="Wichadakul D."/>
                <person name="Arnamnart N."/>
                <person name="Rodriguez De La Vega R.C."/>
                <person name="Luangsa-Ard J.-J."/>
                <person name="Giraud T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIS4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="102" mass="10714" checksum="9729CD4BF6BAEFE5" modified="2018-11-07" version="1">MPFLPLLCDVRRPRAGYGRPGVTVSGAPAKLLPIAKDTYTEANYIAKEGTPCLSYFKKGSLTYPMFLPSYGPYGPYGPSVTYGGLGPATAGPASQCLALPPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIT1</accession>
    <name>A0A367LIT1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Sfi1 spindle body domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_5944</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIT1"/>
    <dbReference type="STRING" id="1330021.A0A367LIT1"/>
    <dbReference type="OrthoDB" id="5215300at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013665">
        <property type="entry name" value="Sfi1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08457">
        <property type="entry name" value="Sfi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sfi1 spindle body" evidence="2">
        <location>
            <begin position="385"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="850"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="978"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="854"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1083"/>
            <end position="1094"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI14334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1103" mass="123919" checksum="AD0F6AD11F2C93AC" modified="2018-11-07" version="1">MSQHAMVRQSTNFAKQRPQTNRSVSTSACLLAQMVPSSKQSSDNGYRLNPTLSRVGHDLYYSNQDITILHSVVVAAQQELDHAPEPKPLPAAVLFRAYDEVLPAYGVDPDLDHHLSAFIFRIGGEEGHETLLSKFQAILGRMGIVLEFGDNTPTPDATPSLSLSPASSHQAKLVEEEHDVSGSSSNSNTAALSSDRDALRSNHSHGGIHAGQNTETAGIHANAVTTFRSPRDDPENQLQLHSNERESAKVAERPSLDGRRSALVAALDVWRSRAAASGSQHKNHQYGSDRNRWGHNGERPQNQHQPATIKNFTSSADPDNVRHKSPRDFVDTAIQEKKVLRFASAASSIASLASEHHESRGHNRLDRFEDEDVTPSLSRQNYLLHCATRARLIYLASKVLNHWADRTATRLEREAVARRHMIRFRCFRSWSQAPSSRLPAVDKLRASAAIQKLQRAVTNQRTQLSRAESSVAEAHSIRLVQQALSRWACQASVHDSLCRSARRTRFNAAARWIVDARETEEIRHAATAHSVGWKSGLAMHKWRAKTEYGSMCQEVAHHIRAVSLSSAFLDYWSDYAEVKRRSLAYWRECQRKKASFAFYVWNLSARAQAARWRHEYLSVEGAFMTWQNETAKHDDTKTAARQHNVLRSKSSFCQRIKQHQSERAELKRLEGRAQLFLNGTLLLKVFEATAQQRKDQMRNRIRQYLMMRYTQISSRRKKRNFLAALDRWKLSSESAIQTARMAQDISAMDEAGRFFSALGSWCSQAAADWRLRCRAESQFRRRCLQIWVKRSAEQEYRNARAGMIWTSERQRRCVKLWSIATLRRSGQAHTADMVLRRHDRESRGRALQKWKTATKGQQGLFSDNAPSVSRARPSSLSGQRRREKQAEVVSSLMETPTRWTGLPLSMAETTSSRRMTPVIEADDETQTVSGNTAADARAWKSQHGESYNTAVHVPQPSSTTPFASVPAHLRRNIRPLSSSWGRLGSATPLQDRMPRPDRWQFGSYSTGPGQAIGSGPGSIDLNPTTPKRLDSHLGRSARWQGTRIGQAEGSPAASMSKGGEVSRGQGPLPQTAASKQVVYNVRPSISSQHSSPYNEDNGKYNDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJM9</accession>
    <name>A0A367LJM9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Endonuclease</fullName>
            <ecNumber evidence="17">3.1.30.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">L249_6412</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2 17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the DNA/RNA non-specific endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.30.-" evidence="17"/>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJM9"/>
    <dbReference type="STRING" id="1330021.A0A367LJM9"/>
    <dbReference type="OrthoDB" id="5418055at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006309">
        <property type="term" value="P:apoptotic DNA fragmentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00091">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.570.10:FF:000004">
        <property type="entry name" value="Nuclease 1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018524">
        <property type="entry name" value="DNA/RNA_endonuclease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001604">
        <property type="entry name" value="Endo_G_ENPP1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020821">
        <property type="entry name" value="ENPP1-3/EXOG-like_nuc-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040255">
        <property type="entry name" value="Non-specific_endonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966:SF5">
        <property type="entry name" value="ENDONUCLEASE G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966">
        <property type="entry name" value="ENDONUCLEASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01223">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00892">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00477">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01070">
        <property type="entry name" value="NUCLEASE_NON_SPEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 17" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 17" id="KW-0540">Nuclease</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase" evidence="20">
        <location>
            <begin position="111"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="ENPP1-3/EXOG-like endonuclease/phosphodiesterase" evidence="19">
        <location>
            <begin position="112"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="34"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU366055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RCI14636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="365" mass="39534" checksum="FA2E60D6A104A84D" modified="2018-11-07" version="1">MSKSTLAMFAALGAGGGAALTAAVYSLRSSYKATTNSSTTSSSTSSSPPSTSSRPSPAEVFAASSPTSSTLAAAAAAAAAAAAAAKTSCDPVNPAGLFEYGFPGPISDLAFRSALVSSYDRRMRNPHWVVEHITPASLALRDADRRSSTFSEDEDVPSKFRALLRDYFRSGYDRGHQVPAADAKWSQYAMDDTFYLTNMCPQVGEGFNRDYWAHFEDFCRRLTIQYPSVRIVTGPLYLPRKDPVDNKWYVRYEMIGSPPSVAVPTHFYKVIFAEDGKAGGNVAIGAFVLPNTPISNDKPITDFEVPVEAVERASGLEFATKLPAYRRRRLCADTACALVIRDYAERQKAFAKNDSKRAIAPPPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJQ0</accession>
    <name>A0A367LJQ0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_6953</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="6">tRNA modification; N(7)-methylguanine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat TRM82 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJQ0"/>
    <dbReference type="STRING" id="1330021.A0A367LJQ0"/>
    <dbReference type="OrthoDB" id="339900at2759"/>
    <dbReference type="UniPathway" id="UPA00989"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106004">
        <property type="term" value="P:tRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03056">
        <property type="entry name" value="TRM82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028884">
        <property type="entry name" value="Trm82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16288:SF0">
        <property type="entry name" value="TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT WDR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16288">
        <property type="entry name" value="WD40 REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="34"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="226"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="527"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="527"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI14658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="546" mass="59476" checksum="77ABF19A8BF6FD6E" modified="2018-11-07" version="1">MLKIPYNRLHVRGKILFAARSGRIHSFSLNDGKHISTWQHPDDKNADSEPPPAKRQRRNDDDDNGRRNGDNEPGNDAVEDGDEVQGGKKTKTRSGGGGGGRPVARVPDRAVVTQLTSSLDGRYVVAVSGHDKIIWVFDHDGNGNLKPLSRRTMPKRPSAIAISDPDSNIICADKFGDVYSLPLKYTPSTTDSTTARRQMKRMGKTNEPAASTLTVHSKRNLEALKNQAKQLQKKQSEEANGGDKVTTTKAAAANSSEEKEKEDEEEEEGFELSLLLGHVSMLTSLLLANDSKGRKYIITADRDEHIRISRYAPQAHVIQAFCQGHTEFVNALLVMPDFETPQLLLSAGGDHHLITWHWLSGKLLSQTSILDLARRIVPETDKVAVSGLVSLRWPSTSESEDETYILAICEDINAIFTWHLSSTGTLNRPGAIELASPPLDISVVSAADGTNPLLVVAVNPGQSEVKSLQSFRLTIGDENSSSSSSSSSRRLAVRPGLVFGDAALEADETDASPAEIRQLLYTVENLRKQTGENEGASHTDVAVSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LK12</accession>
    <name>A0A367LK12_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7081</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LK12"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="90" mass="10771" checksum="04CA88EFC8FE8D1D" modified="2018-11-07" version="1" fragment="single">TRYKDIRTFSRKKGEFSAFLTNLKDKIRTNKATFRDKEDRIGFLFRFLEGKACKTLKTYLLTKTKDDNLSYKDFCSYIKDSVYCRKRDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LK38</accession>
    <name>A0A367LK38_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_6370</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the phosphatase 2A regulatory subunit A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LK38"/>
    <dbReference type="STRING" id="1330021.A0A367LK38"/>
    <dbReference type="OrthoDB" id="438939at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000066">
        <property type="entry name" value="Splicing factor 3B subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000069">
        <property type="entry name" value="Splicing factor 3B subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000810">
        <property type="entry name" value="Splicing factor 3B subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054573">
        <property type="entry name" value="PP2A/SF3B1-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015016">
        <property type="entry name" value="SF3b_su1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038737">
        <property type="entry name" value="SF3b_su1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12097">
        <property type="entry name" value="SPLICING FACTOR 3B, SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22646">
        <property type="entry name" value="PPP2R1A-like_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08920">
        <property type="entry name" value="SF3b1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Splicing factor 3B subunit 1" evidence="11">
        <location>
            <begin position="241"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="9">
        <location>
            <begin position="747"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat" evidence="12">
        <location>
            <begin position="984"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="140"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI14622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1199" mass="133405" checksum="7E24F3F5AA08A068" modified="2018-11-07" version="1">MSDADFEAVAKRQRERNAAAAGKKSSRGLDASTQRSDSTRQSLVDSADKDLYDKDGVEKYAGYHQSLPMGDGDDDDDAPQDSTLRLAGQYTASREIIDEFARGGGVEEEDVLANRGEKSGRIVDRESDYQKRRFNRVLTPTRADPFAENRQAGAAENGATYREIMQGQELEREEERVRRAIQAKQRDEADAEHAQPTLQSTDKENVESGSTELVTAGRKRKKRWDISSTPAEDHAQAEATPTKRSRWDEAPSVSGPISSDTQRQRSRWDQAPSAATPVGNQGLATPAQPIKVPTLPTAFGTDIGRNLPLSDEELDMLLPGENQGYKVLEFPPGFVQVRAPSHRPIALPSAPTGFVMQDPEQTRLSGQAMAAEISGVGDLQFLKPEDMTYFGKLNDGVDESSMSVEELKERKIMKLLLKIKNGTPPMRKTALRQITDNARQFGPAPLFAQILPLLMEKTLEEQERHLLVKVIDRILYKLDDLVRPFVHKILVVIEPLLIDQDYYARVEGREIISNVAKAAGLATMISVMRPDIDHVDDYVRNTTARAFAVVASALSIPALLPFLRAVCRSKKSWHARHTGVKIVQQIAILMGCAVLPHLKGLVECIATNLNDDQTKVRTVTSLAIAALAEASNPYGIESKGLAGFLKAVGYIIPLMDEEYAIYYTTQIMEILLREFSSPDEEMKKVVLKVVSQCAATKGVSGNYLKEHVLDDFFKNFWVKRMALDKRNYKQVVETTVDIGQKVGVSEILERIVDNLKDESEAYRKMTVETMEKVVTSLGAADIDERLEERLVDGILYTFQEQSVEDIVILNGFGSVVNALGERCGPFLPQITSTILWRLNNKSPTVRQQAADLISRIAMVMKQCGEDELMGKLGIVLYEYLGEEYPEVLGSILGALRSIVTVVGIAQMQPPIKDLLPRLTPILRNRHEKVQENTIDLVGRIADRGPESVNAREWMRICFELLDMLKAHKKGIRRAANNTFGFIAKAIGPQDVLATLLSNLRVQERQSRVNTAVAIGIVAETCAPFTVLPALMNEYRVPELNVQNGVLKALSFLFEYIGEMGKDYVYAVTPLLEDALIDRDQVHRQTAASVVKHIALGVIGLGCEDAMMHLLNLLYPNLFETSPHVIDRIIEAIEAIRMSVGQGAVLNYVWAGLFHPARKVRTPYWRLYNDAYVQGADAMVPYYPNLSEKGLDRPELAIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKE0</accession>
    <name>A0A367LKE0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mediator of RNA polymerase II transcription subunit 18</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Mediator complex subunit 18</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">MED18</name>
        <name evidence="2" type="ORF">L249_6997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mediator complex subunit 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKE0"/>
    <dbReference type="STRING" id="1330021.A0A367LKE0"/>
    <dbReference type="OrthoDB" id="5348092at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.320.10">
        <property type="entry name" value="Hypothetical Protein Pfu-838710-001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019095">
        <property type="entry name" value="Mediator_Med18"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09637">
        <property type="entry name" value="Med18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0010">Activator</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU364150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="281" mass="32271" checksum="0FD28050F0F3F680" modified="2018-11-07" version="1">MYELSLTAPVEQTDFQAACAVLGGICAMPPWQTVSRVLYYQGPPKPAGIANQASIDKPVRKDAAFRWKDLHQSLSRQSFVIQTRYEVVPDRDMGASAPPMDLDAAAGILRWADFPDPPHGRPLLTQRKVVEIWEQKRLPSVMRDNQIQYKTELMEEECRFFRDDVEFCLTRSYLLHPIRDYTTLESRTQPPSGPSPSLPSWDSLVTVDQQRRWILHVKTHVLQDNKPDEIRKAQDRLMSIRTELDGVFDFKTIDRKVHDTRMAMQQPGIQALPQKVMLGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKI2</accession>
    <name>A0A367LKI2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_7103</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKI2"/>
    <dbReference type="STRING" id="1330021.A0A367LKI2"/>
    <dbReference type="OrthoDB" id="4927418at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000477">
        <property type="entry name" value="RT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481:SF1">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33481">
        <property type="entry name" value="REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00078">
        <property type="entry name" value="RVT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50878">
        <property type="entry name" value="RT_POL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Reverse transcriptase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI14934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="307" mass="32633" checksum="C63AAE02B6AAAC22" modified="2018-11-07" version="1" fragment="single">KSASPDGILVGFLKGCGLLLVSFLTLVLRSCIACGHFPARYKESNVTVLRKAGKSPEVLRTPRGYRPISLLNTVGKILETGSVSLLMLDITSAFDHVLYNKLRGVPQGSPLSLILFILYISSLYRRLERQIGIIPIRFADNTNIISTSRTPQQSELLYFIRARTADISSLTLDGSVVVPTQEARMLGHRRLYLPPNAPLPQPPRPLRLRLRPRLGGRPGPRLGVPVTTRVAAGSPPPSLSSPPPPAAATPSSTNTLSSSTATSSLCLLAGTSTTSLSPSPLRSRGAAPVPPSTFGGVRAASGIYTVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LL28</accession>
    <name>A0A367LL28_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carbohydrate kinase PfkB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_6827</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat UTP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LL28"/>
    <dbReference type="STRING" id="1330021.A0A367LL28"/>
    <dbReference type="OrthoDB" id="198885at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01941">
        <property type="entry name" value="YeiC_kinase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000549">
        <property type="entry name" value="Small nucleolar ribonucleoprotein complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045161">
        <property type="entry name" value="Utp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18359:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18359">
        <property type="entry name" value="WD-REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="9">
        <location>
            <begin position="27"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="9">
        <location>
            <begin position="323"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="955"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="415"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="568"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="577"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="591"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI15100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="983" mass="105996" checksum="146348C6C0171B75" modified="2018-11-07" version="1">MLDSNCGIDVPERTVAKVDASSDVLVAGAVAVDLTCDPVNVTDGAPRPCTSNPARIAQSVGGVGYNVALAAHLVSNNTRVRFCSMVADDVAGSTVLSSLRASGLDTSHVQTLQQQSHPDARTAQYVAVNDDKGSLVIAMADMAIFSQHSAPDQWASVTATTAPKWLVVDSNWNPRGIREWLAVGKEYGVKTALEPVSVAKSRSLFCPQAGMAKLGVFPHASLHVATPNSYELEAMNAAARDNGYLELGDWFGVIDSLQMRGARDKFVRLTSPELVAAGVPVQSVQLLPYIPTILTKLGSRGVLLTALLGRDDPLLRDADADEYILTRAAAGHSSVGGVYMRLFPAVERLQQVVSVNGAGDTFLGVLMSGLAQGGRVENLVDTAQRGAVLSLKCREAVSPDLGQLEESISRAGSDLDEFESGSASASDDDGAVPAQEKDSDEEELERLVLGNKTSFRENLFLSRGDVEGADFCAESLGVQDAQMGGLEELADADLFMFDTGGAGGVVAKAPAPKTGREDGAAWEDSDDDILTVSLASIRQNRQLRVSETDDIVSGTEYSQRLRQQYLRLHPAPEWAKHKSGGKRPRRRTSVSSSSSDDGIGSNDNDDDDDAAARPLESFLRDVNRLAGRGDDASKRRTLRPETIGIERVREIPDRHTRPVQSLCFHPEYPVLLSASASSVLFLHHVAPDAEPPNPRLTSVRAEGVDIRSAEFLYPRGEAIFFAGRHRYFHHWDLPSGVVRKTKQILGHQLEFKTMERFRLSPCGRYMAIAASSKQGGGAVNFLSTATMQWIAAARLQSTGGVADFAWWSTGQGLTMLGRDGLVGEYCVESRSFVAVWHDDGCVGASVVALGGHGGPDVLGCHRWVAVGSGSGIANVYDRNELIIVPAQTPLRFKERPTPKRILEQLVTAISILTFSPDGQLLAFGSRKKDSLRLVHLPSCTVYRNWPTQQTPLGRITAVAFNRDSDLLAVGNDTGRVRLWKIRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LL38</accession>
    <name>A0A367LL38_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LL38"/>
    <dbReference type="OrthoDB" id="10388883at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="76" mass="8293" checksum="64CE23605A4CD176" modified="2018-11-07" version="1">MGFGGRQFSMSFAPSYIRDRTALKSSGTASERTTNGSRENGGPEVLVSNSPKSNVLFFFAADKRARRANRTMDLDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LL78</accession>
    <name>A0A367LL78_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_6421</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM170 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LL78"/>
    <dbReference type="STRING" id="1330021.A0A367LL78"/>
    <dbReference type="OrthoDB" id="2131401at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019334">
        <property type="entry name" value="TMEM170A/B/YPR153W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22779">
        <property type="entry name" value="SD17342P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22779:SF6">
        <property type="entry name" value="SD17342P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10190">
        <property type="entry name" value="Tmemb_170"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI15161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="142" mass="15761" checksum="09279B246786DAC7" modified="2018-11-07" version="1">MPYPNDPPPGYQTPPFPSLGLPILGDHTPEKRHTLFTVGASWRFTLLWTLVTYAVVHVAVVLIAFFTHGWKRASWKYSWPFPIIYLIVAGIEAVFAGSVVGLLLGAIYRAGYHAMNTWIPFVWGLINVLVLIVSSFSFSGGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LL89</accession>
    <name>A0A367LL89_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">60S acidic ribosomal protein P0</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_6946</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. uL10 forms part of the P stalk that participates in recruiting G proteins to the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LL89"/>
    <dbReference type="STRING" id="1330021.A0A367LL89"/>
    <dbReference type="OrthoDB" id="10259902at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05795">
        <property type="entry name" value="Ribosomal_P0_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1730:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050323">
        <property type="entry name" value="Ribosomal_protein_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030670">
        <property type="entry name" value="uL10_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039087">
        <property type="entry name" value="L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="7">
        <location>
            <begin position="109"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="278"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="278"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR039087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI15188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="312" mass="33467" checksum="958AC40AF6C30803" modified="2018-11-07" version="1">MGGKTANKAGYFDKLKGLLEEYKSIFIVTIDNVSSQQMHEIRHALRGVGVVLMGKNTMVRRALRTFITDTPDYEKLLPHVKGNVGFVFTNGDLKEVRDKLLSNRVAAPARAGALAPIDVWVPAGNTGMEPGKTSFFQALQVPTKIARGTIEITTDLKLVEAGNKVGPSEATLLNMLNISPFTYGMGIAQVYDQGQTFPADILDIGEEQLLGSLAKCIATIASISLAVNFPTMPSVMHSVVNSYKKLLAVAIETEYSWPEIEELKDRIANPDAYASAAPAAASGGAAEAKPAAEEKTEESEEEDDGGFGGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLB5</accession>
    <name>A0A367LLB5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLB5"/>
    <dbReference type="OrthoDB" id="4912312at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="290"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="420" mass="46882" checksum="170DA79D57598C39" modified="2018-11-07" version="1">MKFKDLLTITATTAITTIITITIPQAQAIDPETVAKRFTNSLRQKVVIDWDSDPPESVHEKWEFTCRAHWSITCWRTFFTLRETLLKPRLSGTKAEEPLISVDYDSVPQKRVLNINSTPIPVHTEDSTWLSEATTHGWNAGATLSQGNSITLSGGYAYSKLTSHLTIKSFGISESCPGGFHCRFETWFYHVQYGGACQRTATISCDGELDMCPLTKTPTGDLEERRQRGQGVIKCSQFFKWGWSSCWDSRGSGFGVSEANCSLRIPILEANRQPLSTLVFVKEDHRGETSKGSSASGRGSRPLPHGNQDRAPVAVKAGTECMFFLDTDEWYDAFLRTYYDSSTGDWFSRLDSPAPIIPQHMHSEDCPPPEFRKPAASVDRHRPVSTASRDGTRLKASLSQRSVPPRNVEVKIVAGFRGFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLC9</accession>
    <name>A0A367LLC9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_6927</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLC9"/>
    <dbReference type="STRING" id="1330021.A0A367LLC9"/>
    <dbReference type="OrthoDB" id="4772757at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF10">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="315"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="4">
        <location>
            <begin position="588"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="886"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="921"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="956"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="991"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1026"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1061"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="230"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI15228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1178" mass="130817" checksum="4E398B285AE5FCE8" modified="2018-11-07" version="1">MALVPKSSLQGLDPPEKAIQDAVRDFQSILTNDQCAQLQSVKAVPDADAVIIFTAQLDHCNRSRKGRSIASRLHDVLQSVREFTAVVDSFVSARPDIAALVWGSIKLTMLGRVKIAVNATSYFEPLSNLFMGFKVHCPLFAEYQALYPNSPRLQKALCNFHAAIVRCCKHAVEVIHRPCLSIPFSRKRALADPYQGQKQLVNVLWHSFRIEFKPDIDAVEASGKEVKAEVALAKAQADRQDQELQRKERESASESRSTLGRFMFRARDDLDTIRQQQLQRDQRRARKERQLLLEKLSSHDYLGPFREARKKRLCNTGEWILLTPQFKRWVSTTSSSLLHCSGKKVGSGKTILTASAIDHVFANRRTKDESVTFFFIRFDDPQSTKAEIVFRSLLRQSLDPLTLSGKMEAGLRELDRMLCPSLEDLVALLQQRIALSKSFYLFIDALDECDALERRRLLDALSLISNMISGLKIFLAGRESLSVELRREFPIAEQISMESVEARLDMSLYVEAALLQRMQTRELFIGDSLHQELKRTLTQHADGMFIWVTYLIDELCSYNCDADIRKALGNLPKNLEETFNRALSRIVSRRHDKIAQRILPWVAVAKRNLTLEELRQAISTEVVQPHSRLDTLVQGIENVVAWCENLLHVDEEDKTVQFAHRTVYDFLCMKSPMPELADFRVNLQEADHRAGEICVTYLHFNDFKTTLAQRPRPIRLPAPEAIAHTALKRRGASGLLFMTLSSKLSSSDESFHATETFATFGRADPDEPAARLQTGHPFLKYAAQYWIEHTADFLNGRSATWNLWQNMVLNGHALAQVPWPGHDSVSSQLQMFRWGCQTRHYALVDFIKGRGVISDSETSSAMIQPGVEGDARLINILLQGVMSPYYLKKPLRESSRHGRIEIIERLLAKGADINAELDVTGGGTALQAASEGGQLKAIEWLLAKGADVNAKPSISEGRTALQAASEGGHLEVIERLLAEGADVNAEPAFGEGRTALQAAAGAGHLEVVERLLAEGAEVNAGPSRESGRTALQAAAAGGHLEVVERLLAEGAYVNAKPADDSGRTALEAAAGGGHVEVVEKLLSEKADVNADPALQAASRGGHFEVVELLLAANVNAGGRSVLQEATEGGYLHVNKGADIDIAKPAEHGNSTDLRAGREKGRQFQMLSRHCSRVGEFRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLL8</accession>
    <name>A0A367LLL8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_6524</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLL8"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI15333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="23615" checksum="46279698EF55B32E" modified="2018-11-07" version="1">MAVIARRFVSPQRSPWPSLTNTPQTSGSTTTASLKTIRRQEQEAVGHLSRIFPREEFTISIILGPDGTQPTVLPGGPGEGSPTTQGPDAVFIPLPTPSARQPGGGVVKSMPAPSPTRTASSTTPTSSSTTLASPSTTSTTSSSSVLQSTVLTPTTISPTSSFVALQSDLQTPSASASPATGAGGTQKDVLPTQGGRVAAIGIAAGVFAGVAFIVMTAAFIYRYRKRKSAAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLR4</accession>
    <name>A0A367LLR4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_6547</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLR4"/>
    <dbReference type="STRING" id="1330021.A0A367LLR4"/>
    <dbReference type="OrthoDB" id="4918558at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="329"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="374"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="447"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI15349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="485" mass="54027" checksum="65F9CF9C20C14147" modified="2018-11-07" version="1">MRVTQSSVSPREPQSRPISSSSSYSQSIGRWLLDRAPQLFPDLPLVYDGRPELLVVGRITLYTAISNNVYNSLNMLSFTSISYICLILTKCFTKCPITFLVQSLLHPQGFIPPDLGFNSPDPTQPRAGLTASQRPLLIPDARLVRDTSVLGSFCSSQLQKPLSAMVIYLYLPHPCILGFATSQCIRSRTSRIFLTEDLTLRFPISPFPPKQGYFSLNILIQAQHSSRIDAITRSPPPRVPLGAHIEPTITHLLPPWISPDLFPVLRFNHRSLQNDAFYVVSKVMTFSQTNLVCSSRVTLGPRVLIYLPFASFFTADDTMGVFNPTPVLALAYLGLRLFQIFLLLTPIVGLLGFFTDTTLTRFGFFDIRLLPEGVAIIFIVSIIALGWCLLTSIALFFADLDGKFVAVIDLGIMGALIAGVYQLRFIQFSCLVRRFFRTALTDLQFRLCIAVKASWVLAIIALITFFGSAVLALLASFLRKPFRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMJ1</accession>
    <name>A0A367LMJ1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane protein 14C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_3603</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMJ1"/>
    <dbReference type="OrthoDB" id="5620at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1740">
        <property type="entry name" value="Transmembrane protein 14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005349">
        <property type="entry name" value="TMEM14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044890">
        <property type="entry name" value="TMEM14_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12668">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 14, 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12668:SF15">
        <property type="entry name" value="UPF0136 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G03720)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03647">
        <property type="entry name" value="Tmemb_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI15629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="12109" checksum="C901373AA9CC23C4" modified="2018-11-07" version="1">MVRYRFSRPQQLEYSAYALAALTAGGGIMGFVRTQSKPSLIAGSAVGLLYGLGGYRLQNNQPYGIELGLLASVILGGSSIPRAVRLKKPVPIVLSILSTFGMLTFGNAYREKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMV8</accession>
    <name>A0A367LMV8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_3329</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMV8"/>
    <dbReference type="STRING" id="1330021.A0A367LMV8"/>
    <dbReference type="OrthoDB" id="5245270at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="588"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="322"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="605"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI15749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="872" mass="96181" checksum="EC1C882A798D7A8E" modified="2018-11-07" version="1">MVRACIRKYSALVLMRLFMAHWFWRVFLWRVFPCIARQNHSQIASRYEDEVFACSINSHEDASYSRLECLPEDCDLGLEEALRLLPSDAEKIRSLDRSLQKLEPEAKLTQCVNIRDALKGKYADVESVSNCYNLVFQQHLGRHILSGKEWDAFNKICRKGHQRLVATSTIGRFWGGDLVLDYGLTSKPMTFCRLSRTAAIKVPRWLDAVVIMNWSIYQRIQTTDKRTPKVNNTVCSIELLDLKRFLKFVARKRQPATTFTIPNGYVLDKYGLLVRERRVEITTTLDGPRRPEATLRPALCQPCLSEAPAEPVTDANADTWYSPSTPVASPSPSAAPEHSPQPPYDVEISTIQRIVAVQSSPLPSSSAATSQVQPHTTSFLLSPRASPGAESATTSLPSSQHPSPDGGDPPVRTDTEVEVAGRRRTSSLSPLFTRRSLCEPSEPSSTCSGPLVPISALMSPLHVASTPPSSSSTSRFLCSLQNPPVEARTALHTKRAPPVSLQPAKRQRTHNDTALPTETAGTDQQPPTATPSAASVESAIAEPSFANLEDRLFEKILSIFRERNFDPEEFSTAVHRALRRCLAETSPGAMAESPAMSVPDEVLSPSHTTGRQNPGLSPLNNVESATVDLSASSAPRCPDNHALNIIMPGKRREAASLTAENVILRGMNTAGRISQDASQCAAPINRLGADPLTVVSDGDTLPTSKSFFIDMEQATWARSEEAQDPGPFEEVDVPQDGLSSPLSGINSGQTPTSTFDQAPNLTTIGKALIEDISLKYADNIIGDIWYFPTSKPPTISLRLPKTLVQTRAQLPAYEASDLRHYTQWEVRHISLDKFQRLVVREGFGMVYWRMVETGAYVSMEVLDSRLHADFNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LN78</accession>
    <name>A0A367LN78_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LN78"/>
    <dbReference type="STRING" id="1330021.A0A367LN78"/>
    <dbReference type="OrthoDB" id="4188028at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="596"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="710"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="766"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="897"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="951"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1119"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1210"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
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            <begin position="257"/>
            <end position="273"/>
        </location>
    </feature>
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            <begin position="281"/>
            <end position="293"/>
        </location>
    </feature>
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        <location>
            <begin position="603"/>
            <end position="619"/>
        </location>
    </feature>
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            <begin position="620"/>
            <end position="629"/>
        </location>
    </feature>
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            <begin position="642"/>
            <end position="651"/>
        </location>
    </feature>
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        <location>
            <begin position="652"/>
            <end position="675"/>
        </location>
    </feature>
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            <begin position="768"/>
            <end position="782"/>
        </location>
    </feature>
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        <location>
            <begin position="796"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="864"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1005"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1032"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1220"/>
            <end position="1229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1229" mass="133091" checksum="23773F37A1320364" modified="2018-11-07" version="1">MPSEPVRQPATGTARGGGRGGRGRGRGRGRGKGRGGGNSSFAVAAAAAASAAAAAAAVGAAATAASKQKLNGGDQDAARVKDLADIRFQAAVDRQRHLEANFHQVVDLVKPALAELCGRSVQGLLQRPDAHLDHEVVRHMSDQLGQKFDKVVAVHEAQNSYNMQLAHDFLQAKTQIAQDEFENRLDDLYDQYYDGLLNKLRLLSSLHAKELPFDLRDDRFEYRVIDDDHFDCDFGKWDELIDGNLVSEAEGARRLNTAARAKSPAAAAAATTTADKEPAAKGKAVVKGKAPASAKRKAQAQPGGLPTPKKATRNATRNAQLLPPAELSAPQPAKGLLAAAKEAAASTEVNTPAPEDSNPTSPEPATPVNDEEIPQEQMSPKPPKNATDADEYGLRSYVHRKTGGPPGEKILHYRFMMPRPVFFEPHEIGFRDSTNDPSRQARGKPKLNKYTWSPNSSHVHVDHRMVNYDYATMTPDDFDQDLVRKHALHPRHGLFLSSSRNESEEAGPYVMPGKPVVYIANPSGRVAHASRSFLPTTTQRSAEEAPLRSQMVASVRRFCKTSAVDHEDIAITEYVESDEQLLARSLGTAERELQASSFLSASADEEEEGGGEEEEEEEQQQQQQQQQQQHQPDPDQATIAADEADEADEAVILDAVEQGQQGQRDQQDPQDQQDQQNRDQDQDLQLLQQPADGDRSMLSFLAYATAFDEAKEATRHAPSASNASQYDAIRDVFTSTRPKPAPVPDDDILGLNLLAQICTLKPRMQESDAATSQLPPLMQDQSGPLPAVEPSQYPDSALQQHPSQPHPQQQLPPQAPLPHSAVQGQNAFYPGYAMQDHRDPHMAAGRPVDPAYNPRGMPGYANEAPPPPPPHPHPHPPASQTYGGHVFWPQQGIGPYPPPLPATSTAHPRMPFSHNASAEPLPPLRPPRSRNHSLVLDEPMHEARMRTNMNAGVNAYYGPPPPRGYSRAYSEQPLPPPPHPAVQPSGADRVLPAPHQQQQKQQQQGYLASSSPPSTYGSQPFGNLGPLGGGQMVQQSPPGTPQAASASTLHQRPAADATNGKYRKLQPAPVPAHRAWSNKPELRTIFWDHKETGSSAALPNSGPTQIRGWNDRGAPSVRFAVPPRPAKRQRTGGSLTLPPLREVTRHPRPGQPMVTAPVPTGPGVSLESMAMYGFGAIPTIGSALPLNEGAAATGHQQQQTGQGACIVVATPEPESEQSIKKRLRPRKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LP43</accession>
    <name>A0A367LP43_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Up-regulated during septation protein 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_2371</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LP43"/>
    <dbReference type="STRING" id="1330021.A0A367LP43"/>
    <dbReference type="OrthoDB" id="5569911at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056703">
        <property type="entry name" value="DUF7801"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029191">
        <property type="entry name" value="Uds1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF31">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN CEP250 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25078">
        <property type="entry name" value="DUF7801"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15456">
        <property type="entry name" value="Uds1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01160">
        <property type="entry name" value="DUF1751"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="7">
        <location>
            <begin position="44"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="Up-regulated during septation protein 1" evidence="8">
        <location>
            <begin position="333"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7801" evidence="9">
        <location>
            <begin position="913"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="268"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="705"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="774"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="826"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="858"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1041"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1092"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="282"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="705"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="725"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="776"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1047"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1071"/>
            <end position="1085"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF15456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI16215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1111" mass="123224" checksum="114B32D9F11BE7BA" modified="2018-11-07" version="1">MTFTNAPVTRLAVVGLVSCSIMASVFDMKHKLYIIIDSHLWRDQELWRLLTYQLCYVNSTEVLFSAMSVYNLRVVERMWGSRKYASFIVVSYLLTALVGPLIMVVLRPLSAGLFNYMPAGPTPVIFALLAQYYAIIPHTYKYRVAASPAADDAASGLTLSDKSYQYLIAFHLSVLQWPGSLVGAVVGWLVGHAWRGAVLPASLVTWRLPGWMVGLKVQGRSSQFEGLRRRLEGENRASAVSTAIQNQAGGSSSSRVKDTLADMNGFASGRPPFDYGPPVRMPSTSSPNGRSTANGFRRDNANGFGKPASRFNSTGSNQERRLARVDLKDAIQVHLLTETALSDSKKFEILSQEEVDDLKKQSQVLAQRVESTRANLAVQSKYRDAAVSMARLYGTAQPDDPNALEAERERVACERQCELLAAELFNLEKRLMGPQRRLLEHTAGILQLTHKASKKRRPPPPIGQLINGIPGSPESLYTYSLSGSSLDQVDDDNEFDDPSLYPLDYDGARVANGRSKKNAIEIPVKSPIREHNQLRGEMDRVREENMQLRGQTDMVIQKLESLNGFLRETIVRFNPEVNGGYVQPPKPTSTQNPQPAELLKSQVEYLERGLVAVQAEQESFVAGKDMGQRIESVNLQLRDLLMSADAHYTPTPIPPESDVRGQLSYLEASIQLVDGHMGRGASKGLDAETGPVLTRLWESIQKGALEARQRKEEGRRARSEKGVPADDDDDDMSQDEGFDPTEPYSLPAFASRVQFLHARASTLKDQKSVLKRQIKQQRELNSKSDAEKDQEVVRKQKELDQTGERLAKVEKEALDAQKLLSQALEDLEGARSSAKASESGEVQERDAKIGLLEAQLKETRERAAAAESEGGGAGQKLADMEARIASLTEEKAATDDKIQTLSKELEEKTARLADKEQKLEVKEVELEQLNMTLAELKTEVTIARAELDGAYGSRAERAADVAALKSSAEVVKLQNQVEKLKQELGETVKELEGITKETIGAEREKVELEVKLDEALSSKTGLETEMQRFRDKVAKLEEELDAERLKASSSPASGGRPGAGASMLSEQFRATMREERKRFQEDLKEERAKCRKLEDELNRLKRGQGQGLSPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPU7</accession>
    <name>A0A367LPU7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_2475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPU7"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI16448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="60" mass="6803" checksum="C43B8779E42D2E7C" modified="2018-11-07" version="1">MHGAYTSYRLLKRNASLPMRRSQVQCAMPARQRLPIFKTTTTKKISRHLACQAQAKTKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQ38</accession>
    <name>A0A367LQ38_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SANT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_2438</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LQ38"/>
    <dbReference type="OrthoDB" id="10258692at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034967">
        <property type="term" value="C:Set3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013958">
        <property type="entry name" value="DASH_Dad1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051571">
        <property type="entry name" value="N-CoR_corepressor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13992">
        <property type="entry name" value="NUCLEAR RECEPTOR CO-REPRESSOR RELATED NCOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13992:SF39">
        <property type="entry name" value="SMRTER, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08649">
        <property type="entry name" value="DASH_Dad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SANT" evidence="2">
        <location>
            <begin position="981"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="632"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="919"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1036"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1331"/>
            <end position="2022"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2078"/>
            <end position="2105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="674"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="731"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="769"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1036"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1145"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1206"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1263"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1344"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1372"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1431"/>
            <end position="1451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1480"/>
            <end position="1496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1528"/>
            <end position="1635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1667"/>
            <end position="1676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1794"/>
            <end position="1813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1814"/>
            <end position="1823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1859"/>
            <end position="1868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1879"/>
            <end position="1890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1894"/>
            <end position="1903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1904"/>
            <end position="1913"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1994"/>
            <end position="2007"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI16563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="2105" mass="232880" checksum="C7C6429360B6345A" modified="2018-11-07" version="1">MPPPTHLNLPYRTSRYSRYDSDRRSRSPRERSPDRFERTSQYGDGERRRSSAEARSTSSGFPVARDSFGDPLRREPPRGPKALVEPPNGPRGGGFAGDFRGSRGRARGRPWPSRDGSRDRGRDRDMDYRDRYRDDRSRERDRDRDRDRDWRESRDFRSRRSPAGRARSPVRDFRDRDRDRDRDRDRDRDRDRDGPSGVDADRSRRDSRDGGPPSAGSASSDTQFALSAFGRGGGYVRGRARGNRGDWSASDRGRGRTTYDDRGDRYPRSRSQEARWTRERDERDRGDRYPEMDVRRDPRDERDRGDRDVVRSKKEIRPQDPPTQSREVSPPPVAPSAPAFGSVPSRSASGGDISASSGTFKPQTTPKALYERPVSAGHDLPPVTAPPSRSSVHECHSIPQGPRAQQQRSISKQWTQPNLKMPSVSPTMTRGHVPGQPSTAPFQRTSSYADQAERQRPGSSDAMSPSRASGSEERPRSQHSAEPGEIITVPEPSFRQERKPAEYNAVITRVSDPATEPLRRQGPAEQASGPISSSRKRKRADVPVSRFSVPHKVSVGRQDSESDDDDDDDDDDDDDDDMADYFYKEIRKTEDKLSKLSEPSLPRGVVAHYAAVSHGSMVQILNQSEGLTEMLTPLEEPHDDSQSVSEPVASESKAPEAGLADSAVSHETTEPMDIDTHVEDLREPASRADDVQTDTASAPVPTVTEDGPAEAIHQVQVSKASPEVKAPPAKVEAKVEETLAKDHTPRPLPSEPVENGLKLPSTPSPVADKDDDEDDDETESDEEAFVDAQTTRQLMTTPPVDSLPDYSLKDWTKDEEFLASLEPNQALNDFVTEHLRNIHLQEAEAQRQSQREYAENYGRYLKFTLSDDPTAVKSRDKFSVSVPTVEAVGTVTPETRTEGRGTGRRFATERDLERVLQASMREDEERKEREQRAQKEKYRSDKEAVIPSMYCSDEQRNRVQYTDRSGFVPADRLVSALNILPPVNNFTQEEAELFEKRYLELPKQWGKVAEAIPRRDFGTCIQYYYLMKKDLNLKEKLKKQPKRRKKGGRGKQRSSALVSELGNGEQEGDENQDAGENGERRRPRRAAAPTWGFEQPATDSENATPAGTPGRRGGASSAAKTDQPEKTDGRKGRRKTAKDKEPKAAKATQAPAAAQVPAATVQSGGRGRSRSSSRAPNTEFPTPAAPDASNARMPTTTPFEQPSAVPSGIQPPFSIQQQQQQQQQPPPPPPPTMVERPKPVAASSISEVMTAPSLRPEPPPPHQSSMTTFNLVQPQTERKAATQPTSYWSVSEANDFPSLLRAFGSDWTSIAAHMGSKTAVMVKNYFVRQKDQGKAEWEGIVQEADAKRLRGEKRPDPPQPTTGGRGRRYDNSTTTATTTSTTSTTTGPSRPIAVAPGMDIPSEAMQAKMEGGPPQQPRPPQTFSGYGVPIAQAPGHQPLAQPAQQPMNMQQHVMSQPVAPQAMSPTNHPLRAPMQSFSFEPPPPPPPPPPSHPQVPVPQKTGAGAVSEGRDQRPLVAAQPLQPARSEVMMERQKMAHQQRERERAERERAEREREAEREKEREQQERERVREREQREQRERELERERERERERERERERERERERERELVRQAERQALRNQEAERTSQRHFDPYGHCRQPGHGGVVGVGTRESLQSSGPAPEPYSVAQAAQSAAAKPRPPEPRKTSNIMSLLNDDPPPATTKRVGDVSATIPGPSATPPPPSMGRTTPAPSQMRREADTNYSPYGRGPSGGGPGMPPLKPSYPGSSSPASHLGSAPSERELFTRQHAYARGHHSSGTSSPQASHRYGTPTQAQHQAPGGYHAAYGGGQHAASPPPQYAVHGSASRTREVPQGGSRENAWPQQGHQQPVASMPQGGGWPTQPPKAQGPPPQTQAWAGQQHMSTTPTPAQQSWASAPPPPQHMGMRDERVYGSSSQPPAPHRYATPAPRGPEPIPPQAAAYARYGSTSGPVAPREAGRSYTPGMYDGRATKETATMPPPPSLPPQPPPSQQVMGKTAGSSGEKTYFEQQRETLVGEIATSLELVLANINKLNRSLEAVIAVGNEFSSVEALWSQFESVMAKRNEAEVPEEEELKSDSQRKGFQTQQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQ94</accession>
    <name>A0A367LQ94_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQ94"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="250" mass="27175" checksum="6271EC3C6E0C0EC5" modified="2018-11-07" version="1">MVVQERFWMGVGGIGMDGSMDSMVGDSPTSVVWSPDGGRIGGGPGREDERRRRICDLARWTIRGQTDIFVAHSDVLSGLIKEDTRRLRAPFISSRQRSWHIDSMRAIRPARPPIPKHIVICRSSHTAEHHCLWGGGGKKRGNGGLVARVGNVVDDAVRPGIGGGRREKEEEEEEGGGEAGRADNSLVASRPLPSERMIQSLRADSPLSIPKKTCHAIVVTDVVRWPALTGQLASAAVRDTVRKSAARLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQD3</accession>
    <name>A0A367LQD3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_2954</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQD3"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI16597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="64" mass="6821" checksum="F566F87A1AB62E6F" modified="2018-11-07" version="1">MTLGCSRRLKALGNFVFMSRPGANGRAAVSHAGDGMNSYSALGTTLDSSDPLLSREREEESKLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LR33</accession>
    <name>A0A367LR33_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamine amidotransferase type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_2043</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LR33"/>
    <dbReference type="STRING" id="1330021.A0A367LR33"/>
    <dbReference type="OrthoDB" id="14446at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061672">
        <property type="term" value="C:glutathione hydrolase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008242">
        <property type="term" value="F:omega peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01908">
        <property type="entry name" value="YafJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000045">
        <property type="entry name" value="Glutamine amidotransferase DUG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026869">
        <property type="entry name" value="EgtC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052373">
        <property type="entry name" value="Gamma-glu_amide_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43187">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE DUG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43187:SF1">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE DUG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13230">
        <property type="entry name" value="GATase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="3">
        <location>
            <begin position="2"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI16878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="350" mass="39165" checksum="3D564DDABCC008D4" modified="2018-11-07" version="1">MCRFLVYKGSDEILLSKLILDPDHSILKQSFDSRLRLDTRRGQNNADGFGIGFYTDPKLGAAPCLFTSTIPAWNCTNLHRIASKTASRLIFGHVRATTEGSLSEDNCHPFTHGSLMWMHNGNLGGWKHIKRRLGQRLADKWYLGVKGGTDSEWAFALFLDTLERLGHDPSACPETGFGPTVLRKAMEQTIAQINQLTDSIPQDVVGADDVDTRSLLNLALTDGHSVICTRYVSSSKDEAASLYYSSGTQWATRTTDPDDRNYQMERRDKGADIVLVASEPLTFERENWVNVPTNSILTIHRQTVMMHPILDRHYERDPCHVRSSAFVQTKGLVSNEKAPSPAHEPTPVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LR53</accession>
    <name>A0A367LR53_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein PNS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_3252</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Probably involved in transport through the plasma membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cell membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CTL (choline transporter-like) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LR53"/>
    <dbReference type="STRING" id="1330021.A0A367LR53"/>
    <dbReference type="OrthoDB" id="420519at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007603">
        <property type="entry name" value="Choline_transptr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE (SLC FAMILY 44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12385:SF88">
        <property type="entry name" value="CHOLINE TRANSPORTER-LIKE PROTEIN CTL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04515">
        <property type="entry name" value="Choline_transpo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="431"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="641"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="680"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="120"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="177"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI16891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="744" mass="81069" checksum="E2B37D8DEE2853E7" modified="2018-11-07" version="1">MFSEYASRFLAQSQSRLSTVDSDHPSRPNDWPPSSRPGRSQRDAARANPQARTILSRGNPYQQNGTGSRFGHLGFASRISAAQDAPLFHSTLDEFREEDDEEEREREAADLFALQRSRRVAAASKLAESAESAASHASMGESSGGHPYSGHALARGIKSSWNGARSTHRRLSSYDSPIDDDDDDDDDDDDASQGKGKMVDVGLESQEDADGDPPESLIGGEAPADPNSPFKPASEQEPFISKTSSIDSEADYDSRRQFHAEAENPSLVEGELFRHDPFFAWIFLISLAGMMSTFFLVWLHTSPRKSPVGDTIYTTLQKSFDMLAVDTVVSIFVSLIWLAALRSFVRPLVSVILVAVPVIMLSFSLYSFISSFQGRTHGASVQDSLMRWMSLVPAGACVLWLWLVVKGRQAIQQAIEMLQFSSKILAQNPGLLGVGFGCLGLIVLWTWAWLAMFTRVFMGGYFSKSLVRFVIQLSSWWLGAAFVLMYLWTLAVINAVHRATTAATVSQWYFHRNAGPVTPSRDIVTAALSHATTTMFGSICQSTLLALLLRAPLLFLPRRVGVGLANVAAFWVPTPMMALTNPLTVTYSAIHSQALATSARGLDRMDVVAPTMATTTLTPRALRVRGGAAGSGLLPYRLAKLLLVATRFAMATGLGFAGWVMTAKRLQIQMPDGMGVRGSAYAYVVGIMASFIGYSVMGAVEGILSGIVDAVLICYGSERRMERGQGRFCLEAAYLFGEGRPGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRU9</accession>
    <name>A0A367LRU9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyanovirin-N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_3196</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRU9"/>
    <dbReference type="OrthoDB" id="4672515at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.60.10">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011058">
        <property type="entry name" value="Cyanovirin-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036673">
        <property type="entry name" value="Cyanovirin-N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08881">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51322">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016900223" description="Cyanovirin-N domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Cyanovirin-N" evidence="2">
        <location>
            <begin position="44"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI17174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="160" mass="17034" checksum="C5F31939B6DEF34F" modified="2018-11-07" version="1">MNKNALLPLLALSLGPAAAQLSTRCLFVGFSDGTASRPVAYTSKCSVSEQGEAEVCSQLDLSHCLKNSNGSLGPAGEADGGNFKETCPSCHVEDKGKKLFCVCQREDRTFGYTSVDLDNVIVVKEGDGVLTCSTTVGRQMTECPVTRMGEPPKRRQELVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LS00</accession>
    <name>A0A367LS00_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LS00"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI17167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="60" mass="6669" checksum="E4D479A1ECAB5875" modified="2018-11-07" version="1" fragment="single">YPARNFKNAPIALQEYYNCYVNAPGPPLAAAAADKLYNDDDDDNRATLTAVAPRVRRYPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LS10</accession>
    <name>A0A367LS10_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_3093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LS10"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI17022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="252" mass="28759" checksum="CDC197ACE4B09F47" modified="2018-11-07" version="1" fragment="single">MILLKDFVQSVGRRRNIAPPPPLYPVLQHYAIVGKREKKGAFDGVRPVVSVSSGRPPTAVTPSRHPAELGVLAWGGGDEFEWLSSLPVINVFLHDVVAVSNHACCLHIALAHVGRRQRSMNAQAYAPAEQRESRIELRSSRGGMRRLQTAVFLSFHLRLVSLEKRRILSYHPLERRGEELGGGHFSPVRDRVMSIYKIRLHLLVIEEEPPRIVSCWARREAQAMPKGLYESEYICHRGMVDKDYMYKRRLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LS32</accession>
    <name>A0A367LS32_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="4 10">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_2242</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="4 10"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LS32"/>
    <dbReference type="STRING" id="1330021.A0A367LS32"/>
    <dbReference type="OrthoDB" id="4187847at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000006">
        <property type="entry name" value="Mannan endo-1,6-alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF36">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016794143" description="Mannan endo-1,6-alpha-mannosidase" evidence="13">
        <location>
            <begin position="20"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="440"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="404"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR016302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI17219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="464" mass="50054" checksum="CA13AF74601E8FAA" modified="2018-11-07" version="1">MDMASCVSVLLLAATLVAGQSQSPFSIESADAIKSSASTLAWDMLQYYKGNQSGATPGILPGPPPAGDYYWWEAGAMWGTLMDYWAWTGDSTYNHLVASSMLFQSGDHHDYQPPNVTLSLGNDDQAFWGMSAMLAAELKFPDPPPDKPQWLALAQAVFNTQAHPDRHDDYCGGGLHWQIPSTNRGYNYKNSIANGCFFNIAARLYRFTGDESYAAWATRTWDWMEHVGFLNKETYAIYDGAHVETQCTDLNRAEFSYNNGVFAQGAAFMYNATEDPIWKARTEKLVDFGLKKFFPEGIAVEVACETVGTCTTDMITFKGFMHRWYSVITQIVPSTYDSVAPVLKSSAAAAIKQCNAGALGRQCGFRWATGAYDGRTGAGQEMNVLAAVSSQLIFMGGGDVSPPAPVTAKTGGTSKGDPNAGSGGDETPDPLRPISTPDRAGAGTLTVIAIIFTCGLSGWMCLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LSG9</accession>
    <name>A0A367LSG9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2093</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LSG9"/>
    <dbReference type="OrthoDB" id="10603921at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI17396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="491" mass="54872" checksum="4AFEE562DCA7F0EA" modified="2018-11-07" version="1">MGWERTSPLHHTDRDNDGLLQVHRQSDPMMAASSEEGNVAGVSLANPSRSAEPQPQPQPQQIFQAQPAVAIKLLADIHNYNNICIKTTPASENKGGKEADVLTMHLHSFTTIINSLSLSQLLWPVLCEAGLIWPWSNSRRPSHASESYSVGRSTFYRNPASAPSSMAPASFLHLAPERNKMSPGHTFPAGRQSQSSTASLPRRPGTLTKQVGGKVTLLLPPEVKPPFGPSTPVGYGATPGRQQRSVRMPSRATVMPANFRKQPLVYEKIHHEVPKATVRPANLRKPPFVYEDPREVDRRPALPKKAIAVPPPVASQNPPEPPLPPPRKRRKQRLKYVEPINRPAFSSFRPPEPELSSKASDGSPEEYGRRYEKIDEKHVKPGPEMPDTPPPTPPPWPEHLGRKQSTNVWHLAGLEVEEARHRNQQVKRIETLMNRSNGYHRRLGLMLRGESSVNICKIQRTQIHYDESQGTAKRERPIIYPSLSRKYPILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZW3</accession>
    <name>A0A367KZW3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5767</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000024">
        <property type="protein sequence ID" value="RCI07733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZW3"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016975397" evidence="1">
        <location>
            <begin position="19"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI07733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="73" mass="7914" checksum="FA218F20C7BC4010" modified="2018-11-07" version="1">MLTRRLIILLKKARLACSLTYPTFLPSYGPYGPYGRSRSAVTYSLCDVRRPRAGCSRPGVTVSGAPAKLLPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0G8</accession>
    <name>A0A367L0G8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Endoplasmic reticulum-Golgi intermediate compartment protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_5887</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ERGIC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000023">
        <property type="protein sequence ID" value="RCI07918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0G8"/>
    <dbReference type="STRING" id="1330021.A0A367L0G8"/>
    <dbReference type="OrthoDB" id="270930at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF25">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="9">
        <location>
            <begin position="8"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="8">
        <location>
            <begin position="141"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI07918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="431" mass="47664" checksum="4A9984B395516158" modified="2018-11-07" version="1">MPAKSRFTRLDAFTKTVDEARIRTTSGGIVTIVSLLVVLFLSWGEWVEYRRVVIRPELVVDKGRGERMEIHLNLTFPKMPCELLTLDVMDVSGEQQHGVAHGVSKVRLRPQSQGGGIIDIKSLALHDEKAAHLDPKYCGECYGASALTTAQKPGCCNTCDEVREAYAAQGWAFGRGEGVEQCEREHYAEKLDSQREEGCRIEGALQVNKVVGNFHMAPGRSFSNGNIHVHDLKNYWDSPDGKKKHDFTHTIHQLRFGPQLPDDVKQKLGGSEAMPWTNHHLNPLDGTQHDTTDSNMNYMYFVKIVPTSYLPLGWERKVLKLSGAMDGGIDGSVETHQYSVTSHKRSLSGGNDAAEGHAERQHSKGGIPGVFFSYDISPMKVVNREEQSKSFLGFLAGLCAIVGGTLTVAAAVDRGLFEGTTRLKKMRSKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0R0</accession>
    <name>A0A367L0R0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RmlD-like substrate binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7833</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000022">
        <property type="protein sequence ID" value="RCI07987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0R0"/>
    <dbReference type="STRING" id="1330021.A0A367L0R0"/>
    <dbReference type="OrthoDB" id="16464at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048269">
        <property type="term" value="C:methionine adenosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048270">
        <property type="term" value="F:methionine adenosyltransferase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05254">
        <property type="entry name" value="dTDP_HR_like_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="DTDP-4-DEHYDRORHAMNOSE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491:SF4">
        <property type="entry name" value="METHIONINE ADENOSYLTRANSFERASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD-like substrate binding" evidence="1">
        <location>
            <begin position="10"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI07987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="297" mass="33125" checksum="B1EB250AE3D1C682" modified="2018-11-07" version="1">MNNVSHKPRFLIWGANGWIAGQLRVLLEAQAKDVFTTTVRMEDREAVMQELARVTPTHVINAAGCTGRPNVDWCEDNKEATVRSNAIGILNLADCCFQAGCLHCTVFATGCIYQYDDEHPIGGPGYTEEDEPNFRDSFYSLTKSHVEPILKSYGNCLILRLRMPVSDDLHPRNFVSKIASYSRVVNIPNSNSVLHDLLPAAIVLAENREVGVYNFTNPGAISHNEVLDLFRDIVRPGLTYENFSLEEQAKVLKAGRSNCELDATKLVAKLGELGVDVPEIHDAYRQCFERMRAAGIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0V7</accession>
    <name>A0A367L0V7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cep57 centrosome microtubule-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_7868</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000022">
        <property type="protein sequence ID" value="RCI08054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0V7"/>
    <dbReference type="STRING" id="1330021.A0A367L0V7"/>
    <dbReference type="OrthoDB" id="76453at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051756">
        <property type="entry name" value="Centrosomal_MT-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024957">
        <property type="entry name" value="Cep57_MT-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025925">
        <property type="entry name" value="PPC89_CLD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19336:SF9">
        <property type="entry name" value="SPINDLE POLE BODY PROTEIN PPC89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19336">
        <property type="entry name" value="UNCHARACTERIZED DUF1167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14197">
        <property type="entry name" value="Cep57_CLD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06657">
        <property type="entry name" value="Cep57_MT_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPC89 centrosome localisation" evidence="7">
        <location>
            <begin position="350"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="PPC89 centrosome localisation" evidence="7">
        <location>
            <begin position="531"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="Cep57 centrosome microtubule-binding" evidence="6">
        <location>
            <begin position="846"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="13"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="89"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="360"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="643"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="829"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="441"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="185"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF14197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI08054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="971" mass="108100" checksum="752B5BFD3B723C29" modified="2018-11-07" version="1">MDTDRYRSRILREVQANRANPFNSPPSSTGSHGSDSPTLSSVFSDPDGESTRRLQADIARVTAPRKLPVNWEMAHRKWPEFFSLPSKEARTVDDSTTNPLWTQSRAEMQPRVDDESDMSPALRSAAKSARISSPVPKAERAVAPASPASHPLRRKSSITEALDRLRRASLSPPADAERRLPLRDSVSPQVSSAKSSLTAVPPSPASLADADAGNHGTSFVRSFLMPDVSHLGDFVTGTLKFSGSMKNGVPIFVKNGKVHDRRERPYNDAHAAVDGIEVPQVEEKIFVSMDMIRDEIVSLQKHHDQVQQYAENLQKQVHKLETQVKSGKHHQETKDKGQADSGLVARNNELELEVASLQARLDASQRKASDSEMERMSLAHEKDRAVSRLQSACDDISKLTRKLSVKEKELESTHKQLETTDQVRQDNDTLRRDLLSLKHGRDEFERENASLRSENEALRKEVKKLREEIESLRSDNNSLQRGDDENRSLRSNNRVLSVDNENLRDSLDGVQHELDAVREEVERLERRVTSLSREKTTLEQDNQNLVQHNDKYFSENNILRREKSSYERSTHELHEIIVKLKDEVAFLKQQPDHCRPLPRDDDVSVRVDEETEENMTSAFFVPDITINTNESAVTETAEMAVPVELTSRSHKTATVVKETAQQTRGEKKQQHTRKSRSNTNSSKQPPKVAFAVPDKDKNLANKGSKRRNPAKKTTGDDTTDALSLDGDQVSMSLNLTEANRQQGSKQRGPIPSEAALPSQAEAADCLLAAGAQPVGTCPAVLSPEARRVLDGLCEHNCRNCVVCSRITAHRGVITSADVAAGKKRVSVTRPVPVTDRNETGADDDVTTRPSQPPGRALALVIKGLEDEAQHMQFELSRLQARYNASDKSLGRRQRLSLADAIRSLLKRLEVKNDQIYSLFDVLEGQKAAGQAMSEDEVELTVLSITGLTIRDLTGGAELLTWDGFFPDHDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1X8</accession>
    <name>A0A367L1X8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DJ-1/PfpI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_8975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1X8"/>
    <dbReference type="STRING" id="1330021.A0A367L1X8"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052158">
        <property type="entry name" value="INH-QAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130">
        <property type="entry name" value="ARAC-FAMILY TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130:SF3">
        <property type="entry name" value="HTH-TYPE TRANSCRIPTIONAL REGULATOR RV1931C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="2">
        <location>
            <begin position="17"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI08418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="292" mass="32006" checksum="069B2A4B15507518" modified="2018-11-07" version="1">MAANKSSAVADQEPIDVLVAVHHKFDLLDFAGPVEAITRAAHDFKDESTKAFEVTIAGPEPKVLSDQGVIIGSQMSFKEAHERLEEFDVLVILGGNTQEILAKEMEPLGLIYDFAELQKKDPARERTILSVCTGSLLLARENILSGLSATTHPDFLTKFEIECSEAAARNMTERTDVIEDARYVVNNLRFDLGDEDENPYIRRQSDAGRRSSTARKGSMSWKGSNSRRESMARRAAMRLGGLRVITAGGVSSGVDAALYLISAMVDDACAIEVARIMQWTWTKGIVVDGLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L234</accession>
    <name>A0A367L234_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cation efflux protein transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_8787</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L234"/>
    <dbReference type="STRING" id="1330021.A0A367L234"/>
    <dbReference type="OrthoDB" id="435980at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000013">
        <property type="entry name" value="Cation efflux family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1350:FF:000010">
        <property type="entry name" value="Cation efflux family protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050291">
        <property type="entry name" value="CDF_Transporter"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43840:SF15">
        <property type="entry name" value="MITOCHONDRIAL METAL TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="9">
        <location>
            <begin position="123"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="27"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="445"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="88"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="455"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI08493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="473" mass="52237" checksum="578ED17983FAD773" modified="2018-11-07" version="1">MAPQPTTNLAASQRVLVLIRYHHSASLRQHHLQPRQLQPRRLQQPQQNRLHPPRRHCHHPSTRRLSSRRPLRSLLAMGSTSHQQTRCHGSHHHHHHHHHHHHHDNTYLISSNKNDSGVRITRIGLMCNLGMAVAKFVGGWAFNSKSMTADAWHSIADLASDVLTLATVSWSLKPPTDRFPLGFGKIESLGSLGVSGMLLLGGLYMGWESAISLYAHFDPDAAHHILEHVGHGHGHGHGHSHSAASLGIPSIHAAWLAAGTILVKEWLYHATIKIARERKSSILASNAVHHRVDSLTGIVTLVAILGANVLDKAAWLDPVGGLLISIMVVNAGVKNTQAALFELADQSIDEEIKAAIRKQALRALSELDVDEAQLRQVSGTKSGQNYLIDLEMAVPGTWTVEHMARLEHQLRTEVGSKVRGARRVRVRFVSRDGGIRDKFDDFIPGSVQASMEPEPMSRREGDKVCGKPRADGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L240</accession>
    <name>A0A367L240_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_8780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L240"/>
    <dbReference type="STRING" id="1330021.A0A367L240"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000611">
        <property type="entry name" value="RAB GTPase Vps21/Ypt51, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI08486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="236" mass="24807" checksum="58B8CFCBD9980FCA" modified="2018-11-07" version="1">MADSNAPKPSSSVKLVLLGEAAVGKSSLVLRFVNDDFQENKEPTIGAAFLTQRCNLPTRIIKFEIWDTAGQERFASLAPMYYRNAQAALVVFDLTKATSLLKAKHWVAELQRQASPGIVIALVGNKLDLAGEQSPTESSDADDGQATGDARKVSTEEAQAYAEEESLLFFETSAKTGHNVSEVFTAIANAIPETSLKSARGAGAAAAAAAEGRAGDEQRVNLGSGRDAGAKDGCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2B9</accession>
    <name>A0A367L2B9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2B9"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="103" mass="11335" checksum="1933E595DFDCC3DF" modified="2018-11-07" version="1" fragment="single">MTGRESAMPPAVSNKRTGLRESEDGVEGKCWSSGEATKQRHPGQVRCGSGESLEFQNTTASGLRARSLFGSVGTTNFRWRIPHDRRPLFAVTDSTPMRILKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2D2</accession>
    <name>A0A367L2D2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_4692</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2D2"/>
    <dbReference type="OrthoDB" id="4755094at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="49"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI08589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="428" mass="47890" checksum="21B864F70024C4B2" modified="2018-11-07" version="1">MDPTAENVLAGQVEETRSSMRKGNVTAEATASQRLADEVRLRLFTEGVLDSRQAELEQQELETKKLKKKLESLHKELAEAQRQLIEARSQSKTKAKQLQDAKDHIFRLQPRRKDISEAEAQEAYKKLCGNVQRWVENRLPAVLDDMEAGRLPNRPDGTLAARFASLIREPARRCLSAHQADEHHVIAVIMYYLWLVLFAKSFYCPLDGSSDDATTTWIDELEKTMSQLPRELAHCREWRSETLTALTSQPLFRSRRTAYLSLVTEDLASLLSVVVPRSSASELQASVRRVMVEPAAELAHRLQLASSIFSLKWPARNASGRLEVYECINLASGGLVLDVGGASTTARQNVTYLFDVAPGLFVERIEVGKKAPLKAIYRPNVLVHAGGDGEVAQRPTLMKWVCESANGSLPRTAVPRRFPGQLPSGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2J7</accession>
    <name>A0A367L2J7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4419 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2J7"/>
    <dbReference type="STRING" id="1330021.A0A367L2J7"/>
    <dbReference type="OrthoDB" id="4924073at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025533">
        <property type="entry name" value="DUF4419"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31252">
        <property type="entry name" value="DUF4419 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31252:SF11">
        <property type="entry name" value="DUF4419 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14388">
        <property type="entry name" value="DUF4419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="38663" checksum="C72E4DE4C9972073" modified="2018-11-07" version="1">MPVTLNIVDHPAENWQLQKVSRRRLRENHISASENGFVWSAYRAYSKHHHLVIRPDDVWLAILTQLSFYIKANAEQVRALFVSHEGRKELEMVDTGSIVYCDFGAFAQNMTTLMSKNVNDPELRTWIMPSFSTTTDDDLVAASVLFMGAMHKYFSYKCTMVCGFPSVTLLGEVADWQDILERLDKLEQLGDEANQFASMLRPVLRRMILSFEQPSSTDVNCFWNTIISEVFQGSGMNYLTGWLSAFCFWDQSGKARSNFGQNAVLDDVCYPRINTNDVPGGFASVPVTVDDNGHVYDCTMIAGSVGMLARSPPSLHRRGAGGDTGRGFRSVYGAHSRPAGDSVVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2L4</accession>
    <name>A0A367L2L4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_4660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2L4"/>
    <dbReference type="STRING" id="1330021.A0A367L2L4"/>
    <dbReference type="OrthoDB" id="536211at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017033301" description="Metallo-beta-lactamase domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="114"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI08671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="370" mass="39645" checksum="D907732158C60EBB" modified="2018-11-07" version="1">MRLDVPAIFVALISLSAACSRHVRREAHGPGPSLTLSARFVPLPQEANIGRSIIKRQNQGKQNVNMFLNRVQNTSAPLFACYIGGESGREPQNALQSMTVNLGNEQADANNDLGVTSYFLSDGKQAVMFDTLTSPVLASACLKMVQSNDQAGNRSNDQGSIGNVQQVILSHKHQDHTAGLPAPELTQARVITQENTRQALAQAKSRPPDETYGESATLALGENKVNLLHFVGHTNDGTGACVGDVCLMGDECEDNVPFIAEPERIQSQIQNLGKTIQTVQGQGVDKVCPAHGNGNTIANGCFSLALCQSNMQYLQIMASNLQAACGQSLQQLAPQIGRQPGDITQAYAGVHQENCQSLRQAQGQGEREMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2R9</accession>
    <name>A0A367L2R9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_8984</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2R9"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI08512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="44" mass="5094" checksum="C2EFBFCD772130BA" modified="2018-11-07" version="1">MLMILPSRYFSRYFKVPTCSTLTYLYVRTLPRCKRCAQGGVGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L383</accession>
    <name>A0A367L383_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_4906</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI08889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L383"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI08889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="89" mass="9803" checksum="AC53AF32DB2BAEC3" modified="2018-11-07" version="1" fragment="single">MQIVALIYIEEGPALALNETVREGVDVRAALRRARPRYPTIGREQLRRPPLAYSEYLIRGSIGGISVSPREPQSSPILVLAGYFAILGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3B4</accession>
    <name>A0A367L3B4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_4926</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI08914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3B4"/>
    <dbReference type="OrthoDB" id="4926787at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016860262" evidence="2">
        <location>
            <begin position="25"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI08914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="165" mass="17145" checksum="04B9308BB8B1D17A" modified="2018-11-07" version="1">MAPLLNALTLTLTLLLTITTPATGQAEIILPNPHPNPSATQESSSSSSSSCKKTLPLVLPINLGPVKTVWTTTTTTTRLVECSACPQVTVSWLFLGVPPVARFTTTKTASTASTTSVLACSSYPPASSSSSSASRYGTPRYPPHLPEPAAVTLAPDSETQIEGSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3F8</accession>
    <name>A0A367L3F8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_5052</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI08966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3F8"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016858958" evidence="2">
        <location>
            <begin position="19"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI08966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="297" mass="34416" checksum="1E4146E8CA6349FC" modified="2018-11-07" version="1" fragment="single">MKLLLLLILFSIITTASPWTYLSPRPVGHLLEHRLCLTNGQCCSQHCFKRHLPRLGFLGKRNSGILFAQDLTNFLAFPLFYGKAINLSTESIYGRYQGSFFFPFVRTEEPLKDGQNLTRRGRCYHKITEEIHADHSYAMASQLKNNLLAEESGHRVFRCRSEGNHKLTIRLESLLGLTLKTDTTIHIMPTIGKWTLEPPLFPLPPSPPNATYPYPSVFETRIRSSQEWAENLSSYPFFCRDKRAAFPSDPGLIWPPFFGEEWKNGIMEEWKKKKKKKKKKKKKKKKSDHDESFVPLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3L0</accession>
    <name>A0A367L3L0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI08988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3L0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="104" mass="11751" checksum="56929216E9B9E67D" modified="2018-11-07" version="1">MLQRAIPPLINKESQGGKQGRDLKKMLAESAAHSIHNRSWVSTFNPALSAVVVDPFIRNSVREDRNGDVFSCSSSSSSSSVSLNSFFFFFFFFFFFSFLFVFVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3T5</accession>
    <name>A0A367L3T5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_5124</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI09084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3T5"/>
    <dbReference type="STRING" id="1330021.A0A367L3T5"/>
    <dbReference type="OrthoDB" id="289721at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.750:FF:000013">
        <property type="entry name" value="Similar to TBC domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000034">
        <property type="entry name" value="TBC (Tre-2/Bub2/Cdc16) domain family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053949">
        <property type="entry name" value="SBE2/SBE22_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF15">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 12 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22874">
        <property type="entry name" value="SBE2_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="430"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI09084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="699" mass="78121" checksum="8B80A12C9BE8C1F2" modified="2018-11-07" version="1">MIREQVITLPMRDSPPGMTTSKSSKSSSFRSLTSHDGSLLGDVGHFEDIGLDDDAVTLKSPPCPPANAPLTRNLASVKRAPTPRRSFPNLRANIYSSNPRSTNLAVLTDPRSLGLPRGPSVVTQSRRNRSTSPALSQNPRDHGRPRVPRRGSWQACRDRKSLAELENECDEDDGDDIPDHIVLDNVPISPRPANERPPSRSPTVSPPPDRVPKDRVRSVGNGTPPVAQDYGSLRSPSWRSDSSDRSPMSASRLKTTNRNAALADLSAEAKALTEKLEEHADEQEEQYFRQPANSGRPNTWASSQTHTVHMYDRKERVKSSTPELPPLRRTNIMVDPLPISKEKEAVLSRTRPSWLPPKDPNEEKRHLREYQEMMAASVRAEERREAARRSKTESRDSNADSLMHIWEKDIVPRWSQAIRERRTRDMWWRGIAPRSRGLVWSRAIGNELGLTAAAFHTALSRAHDVQTRVEMDRGDAEDARRAKWFDRIRRDAGEGTWTELRIFQPGGPLHRALVDVLSAYAMYRNDIGYVAGSNAIAALLLLNLPDAETSFIALANMLNRSLPLSFYTSDQGAQASAFNLVLQTLSQKSRALHEHLTRTVESVEPELYLGHLFTSLFADYLSIDEAARLWDVYVFEGDALLVRAAVAMLLMHEMPLLGSKTAEEIRAVMCRPAGRSAQAVAPVGAEDRFMRLVREAGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4I8</accession>
    <name>A0A367L4I8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome maturation factor UMP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_3695</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the POMP/UMP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000015">
        <property type="protein sequence ID" value="RCI09344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4I8"/>
    <dbReference type="STRING" id="1330021.A0A367L4I8"/>
    <dbReference type="OrthoDB" id="15001at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008012">
        <property type="entry name" value="Ump1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12828:SF3">
        <property type="entry name" value="PROTEASOME MATURATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12828">
        <property type="entry name" value="PROTEASOME MATURATION PROTEIN UMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05348">
        <property type="entry name" value="UMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI09344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="157" mass="17408" checksum="F849736A675E87CB" modified="2018-11-07" version="1">MSMRIAPPSSHATTYNQTTTPAPSAPGIHDTLRAGLGPSSTSHSPSCSCGNENDESVSSHPLEARLRKWEATQHELRMASLRRTFGIAEPVRREMELKMVRKGDWRPAELRSGLPSVHEDILRGTDASLTWEDVFTGDETAAVVSFHQEMDKKLRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4V3</accession>
    <name>A0A367L4V3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyltransferase family 25 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3731</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000015">
        <property type="protein sequence ID" value="RCI09454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4V3"/>
    <dbReference type="STRING" id="1330021.A0A367L4V3"/>
    <dbReference type="OrthoDB" id="47375at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016654935" description="Glycosyltransferase family 25 protein" evidence="1">
        <location>
            <begin position="29"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="429" mass="47711" checksum="BAA53F1EC9598ED4" modified="2018-11-07" version="1" fragment="single">TSMLFHRPVLHFLLIVGLLLIFLRLTNSPSSTTHVKSVNSTLGFGRIYAVSKAGSPRRGRLIRAANVTELHITIPLQPEWTAHDLDGFRLREGSVISNGSALAWLGHLYALRQFLGSGDETALVLEDDVDWDVRLRSVQMPLLSSALGKILPGSVSTAYPYGKPDDWDLLYLGHCGDYWGPVYEGFQADHYKPEDLAETAHVAFADSTMLDMKDLHPWTSSQFARLAVAPSTRLVHRSKFPLCTFAYAVTRASASRLLSDLAGREVKDGPGAYDVAILEACRDKGLRCWTVNPELFHHVPGPSAIGDVDHRNRDPGPVDAMGRARAYERGETPNIGCGFWRGGVEFEHGDHGHLEWLRREYGRKGRCKEKAVEDKMRLLATNSSARCESQPMEITLGIRHNVGDVYVYIYIYTYVCKKVACCSPVLTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4V7</accession>
    <name>A0A367L4V7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_3655</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000015">
        <property type="protein sequence ID" value="RCI09466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4V7"/>
    <dbReference type="STRING" id="1330021.A0A367L4V7"/>
    <dbReference type="OrthoDB" id="4910267at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051637">
        <property type="entry name" value="Ank_repeat_dom-contain_49"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE INHIBITOR 2C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24180:SF45">
        <property type="entry name" value="POLY [ADP-RIBOSE] POLYMERASE TANKYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016644515" evidence="5">
        <location>
            <begin position="16"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="508"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="541"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="601"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI09466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="624" mass="69298" checksum="5FE6EE6849FDD3FF" modified="2018-11-07" version="1">MRLLQVFILIPVASCSEKAADVMTSQVEMMDILHRLEQNTTLREDSLPYWSRDKFEFSCLSLAWWEGFRVHFHEEVQFLPPSHSSSDYGKQGNVNVTVFAKRQVLRRVRNLQETMVTAGSEKSTVTIESTTTGWTVGAQLMAGHLQPVGLLFAQTGLTISASYSSHVTTGTQYSVTERNGFSCPPGYDCRSEAWTSYVKLAGPCIDRHEVTCNSQSLSPCDFTTADQWRDKVNSMWHCQQISSWREKNCNPVRHCEVVTPIMDADGKPVVTEVFLSEPIPDFHPRPRISEYKAGFYLLGSENYLYDPSRQRDKYWKKDIGWHENRAHPNLDAEVAAFPHKAPDVLKFRDGCYKLKSLEWYCPTEDEGEAFIGMDGILDVNKSPYGKTARLTPTTEAMIDCLESEAEKILLGGYDKVTALEVVDEYLRLHDKMQGKNETLLLLWRPVTSRQYGLVGLLINSTKVDVNGRDVKGRTALSWAAGGGGGGSDEVVMQLLGSPKVSLTVADKQGRTPLFWAAAKGRLESVKMLLMAEAKPNKVDKRGRTPLMAAAINGHKKVVALLLRLKTVKVHVKDRQGRTALSWAKAKGHADVVKLLGPSRRRRKPAAAAAAAAPGGESLPVGGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L504</accession>
    <name>A0A367L504_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Coatomer subunit beta'</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">L249_3842</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasmic vesicle</location>
            <location evidence="1 13">COPI-coated vesicle membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Golgi apparatus membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
            <orientation evidence="13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="13">The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the WD repeat COPB2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L504"/>
    <dbReference type="STRING" id="1330021.A0A367L504"/>
    <dbReference type="OrthoDB" id="10261470at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22947">
        <property type="entry name" value="Coatomer_WDAD_beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000016">
        <property type="entry name" value="Coatomer alpha subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000001">
        <property type="entry name" value="Coatomer subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016453">
        <property type="entry name" value="COPB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH_b-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF2">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005567">
        <property type="entry name" value="Coatomer_beta'_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="Soluble quinoprotein glucose dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 13" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <keyword evidence="5 14" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="91"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="134"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="178"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="222"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="16">
        <location>
            <begin position="316"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="17">
        <location>
            <begin position="591"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="817"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="837"/>
            <end position="857"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RCI09488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="863" mass="96318" checksum="AF8D67BE0716C7BE" modified="2018-11-07" version="1">MRLDRQLFARSERVKGIDFHPHEPWILTTLYSGHAYIWSYETQQIVKTFELTDVPVRAGRFVSRKNWIVCGSDDFQLRVYNYNTSEKITSFEAHPDYIRAIAVHPSLPFILTASDDMTIKLWDWDKGWKCVQVFEGHSHYVMGLAINPKDTNTFASACLDRTVKIWSLGSGTANFTLEAHETKGVNHVDYYPHSDKPYLLTTSDDRTVKVWDYTTKSLIATLEGHTNNVSFACYHPELPVIISGSEDGTIRVWHANTYRFEQSLNYSLERAWCVAYQKGQQGVAVGFDDGAVVIKLGREEPAVSMDTSGKLIWARHNEVVSSIIKGDASIKDNDPISLPTKDLGTCEVYPQTLIHSPNGRFVAVCGDGEYIIYTALAWRNKAFGSALDFVWASKDNSNDFAIRESPMSVKVYKNFVEKSGGLDVGFQAEGLTGGVLLGVVGQGGVSFFDWATGGLVRRIEVEPKQVYWSDSSELVAIVCDDTFYVLRFSRESYVEAVQSGQVEEDGVEAAFEVITDISESVRTGEWVGDCFIYTNSTNRLNYLVGDQTYTVSHFDKPMYVLGYIQRDSRIYLADKDVNVTSFGLSLPVLEYQTLVLREDMETAAEMLPTIPADQLNKIARFLEGQGHKELALEVATDDEHKFDLALALNQLDIALDLARKVDVDHKWKTVGDAALAGWEVALAAECFTQAKDLGSLLLLHSSTGNREGLSKLAAQAEESNAHNVAFSCYWLLGDVDHCVEMLTKTGRLAEAVLFSQTYKPSLTVPVVKDWKESLEKGKRGRVAKLIGVPDEDEELFPEWDAWLEAERDGGSAVERTLGQEKTNGDVQDAAEAVAEAAAEDEEAAGEEEEEEEEEEDKSSENEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L517</accession>
    <name>A0A367L517_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinase</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_3966</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="4"/>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L517"/>
    <dbReference type="STRING" id="1330021.A0A367L517"/>
    <dbReference type="OrthoDB" id="338650at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000824">
        <property type="term" value="F:inositol-1,4,5,6-tetrakisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008440">
        <property type="term" value="F:inositol-1,4,5-trisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF103">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE MULTIKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI09498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="369" mass="41092" checksum="526092DD74D94C1E" modified="2018-11-07" version="1">MGHRELPSCDQLREYNYAVAGHAGTMCDADGELFIKPCTQSEIDFYQSAVRRHPEFAEVMPLFMGSLILSDASVESIDETVSGVISDTGNVKTTREQIVATVAEQVACAPVPSHDTWVPNRGKKIKTDKAIVLGNATRGFKCANILDVKLGVRLWADDAPQEKKRRFDKISAETTHHSLGFRIAGMRVFRGSSDPSELDEEGYKIYDKDYGRIMVNEANVVDEFRRFIFNETAGISPELGRGVCAAFARDLAKVVEVMTRHESRMYSTSLLFVFEGDGEALGAAIEENNAKLESAAARNAPDWLAQRYDSGIAMNEEDDLDELEESLPRIYTLKLIDFAHAQWTPGLGPDENILKGVRNLERIFEEMAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L577</accession>
    <name>A0A367L577_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_4045</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L577"/>
    <dbReference type="STRING" id="1330021.A0A367L577"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="46"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI09558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="313" mass="35855" checksum="307A93D9DFC228DD" modified="2018-11-07" version="1">MSYLEEDDSIRFLLPQGVDYTEDIERYKPGGFHPVQLGDRYDDGRYKVVHKLGAGGFATVWLARDENEEKWVALKIVDAEHSASTATKSVLSRSASGAQFVAEHHRHFSFDGPNGRHLCLVLPVLGPSMSELSSGESPFSSPFDVTSPADLLSYIIHTLGEDMPRKWQDSTLWDPEGRPTKDASKGKPHEQWWEGDERSLRDLVYNIWDEPKTRVVQTGNLTSGPEFWVKDEHQPFPQCFSDMVWNPRAIKVDNTYLYGYDEDWDMVLEALPKIPKHEAALLYDLLSKIFVYDTTKRPTAREMLGHPWFHLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L588</accession>
    <name>A0A367L588_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nucleoporin POM33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_3904</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PER33/POM33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L588"/>
    <dbReference type="STRING" id="1330021.A0A367L588"/>
    <dbReference type="OrthoDB" id="5581259at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071786">
        <property type="term" value="P:endoplasmic reticulum tubular network organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051645">
        <property type="entry name" value="PER33/POM33_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005344">
        <property type="entry name" value="TMEM33/Pom33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12703">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12703:SF4">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03661">
        <property type="entry name" value="TMEM33_Pom33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI09577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="31495" checksum="F661AC616E264C87" modified="2018-11-07" version="1">MSPPPNANMSLQERLLHLAKTLQFAWFVGHMTLILSTVRYGFSWLRMNYYGRMAQISYRTSFVAAIVTYGIVVYKTQRARAKTGARASGGLVGQLSDENVQYLLMALVWLFSPQYPLALMPYCVYSIFHVATYTRANLIPVFQAPPTPAPEGGVRPRASSPLADRIGHFVKEYYDASMSVVAALELLIWVRIVFSAMLFQRRSWILLGLYTAFLRARYSQSSHVQTSVSHLSARIDSLVGAQGTPPVARQVWESTKSGVRQFHDATDMGKYVNAGGPVKKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5C5</accession>
    <name>A0A367L5C5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_4165</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367L5C5"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF28">
        <property type="entry name" value="SYNTHASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="10">
        <location>
            <begin position="21"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="11">
        <location>
            <begin position="918"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="2373"/>
            <end position="2449"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="918"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1054"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="8">
        <location>
            <position position="950"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="8">
        <location>
            <position position="1114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI09633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="2463" mass="267406" checksum="CAD6C1C045A6A48B" modified="2018-11-07" version="1" fragment="single">LLASKSIHQQCLAYQKQATAYNPIVICGMALRLPGRLSTPSQLWDFILAKQDARCRVPPTRFDISAYHSKHPRRPGTTKTEFGYYLDDSVDLGALDTSFFSFTKNELEYVDPQQRLLLEVARECLESAGEVDYRGKRIGSFVGSFGDDWVENLLHDTQMYGKYGLMTGGDFALPNRISFEYDLRGPSMSIRTACSSSLVALHQACHAIRRGECSAAVVAGCNLIMAPTLSIILSVKGVLSSDASCKTFDAQADGYGRGEAVNAVYVKPLRDALRDGNPIRAVIRGTAVNSDGKSSGFNAPSVIAQEHLIRMAYSAAGIDNPSETAFVECHGTGTAVGDPVEATGVGNVFGGDERVYIGSVKPNVGHSEGASGLTSLIKTVLALEHQVIPPNIKFNTPNPKIPFKEKKLEVPTEPVPWPQDRCLRASVNCFGMGGTNAHVILESAVSFTPTASSPPPTDAADGRFPQLLVFSANTAPSLERCVKELQHYLQRHPDSLADLSYTLGVKREHLAFRATSVVDSQLPVITASPSVKVPSSPPEVVMVFTGQGAQWPRMGVELYRSNSTFRTSILRLDDVLRMLPDAPSWSMPDEMMKEGGQSNLNRASYSQPICTAVQIALVDVLRVLGIAPYAVIGHSSGELAAAYAADRLTSKEAFVSAYYRGVVSERVTRPGGMAAIGMGKKDALPFLIPGVVVACENSPSNVTISGDLDQLEQVIEAITKAHVSVRRLKIGVAYHSQHMKDVGEEYYCSLLDRHLVDASCCRRSSIHFFSTVTGERLGVDDVVGPRYLQANLESPVVFHTALENLISYASQRQLLFLEVGPHSALSGPIRQTLDRASSRSGDQYISCLARSKNCSESFLSALGQLHCQDIRLDFSALHADGNTRTLTDLPTYCWDHALSTLYEPRYNKEWRSPTRPRHELLGVRVAGSTDNEPCWRNVLHLEHVSWLRDHKIRGAAVFPAAGYVAMAGAALGQLSSGGHGYQVRDLALDTAMVLSDLQPTEILVSLRKSHGSEWYDFNASSHNGAIWIEHCHGRARSSHAGVTGDRDGEVDELARAIDGPSWYQTLRRGGLEFGPAFQRVRDLSSSVTEQVACAGILATVDESEYYPVHPTTIDGFFQTLLAARFRGLDWEADPVPVPTSIGEIEVHHCSTDLHVRSWVTASDGDLTSADGKAFGLDGNVAATFKQAILRPVAAASRSTRERLEKQSAARLHWGPDIRFLRLTDLVLSPPGWNEHSKLLDRLTWACVDRALASLGEHGVVSSSSPHMQRFQTWLQRQPRAAGNGDVEALAAQLSATPAAAPAAAMTKVLENMVPLCRGEVEPLQVLMSDGILHELYDYLNQSDCVALLRALGHAQPGQRLLEIGAGTGGTTAQAVRHVTCSTYTFTDISAAFFPAAKERFKEHEKLIYKTLDITKDPCAQGFEPESFDLIIAANVLHATPSLHETLVNVRKLLHPRGRLLLQELCPVTKFANFIVGILPGWWAGEADGRPDEPYVSPWRWGEELREAGFGGLDDVAYDATPPYHANAYMLATPHVPPGLSSQTVHKSASLVCDATSEDLAVKFREALSGRGYDVKISDLESPLASGQDAVVLVDVTSPFFHDLDASKLSAFQSFVNQLQLSHAGALWVTRSSQLSCGDARFSSSLGVVRTTRSELGLELATCEMDDVGDDDVERVVDVFDKFHGRLDGEMELEYAIKDDTVYVGRMLPFFMEQELESLGRSDLDSDGPPVLQLEVGTRGLLDSLVWKAGAKRRLLGRDEVEVEVDTAGVSHKDLLIALRSKDLAAGRLGFDAAGIVRRVGSRVEHLSPGDRVFTLSPGCLSTSVVTSAARCVKVPDGLSLDDAATMPLVFSTVIYSLLDLAQLDKSQSILVHSACGGVGLAAIQLSKMVGAAIYATVGSEEKAEYLVESHGLARDHIFNSRDASFLADIIRVTRGRGVDVLLGSLCGDLLDASCRCVAAGGRIINLGKADATDDGQLPLHLFKPNTSYNVVDVMDHVRGKPGEGNRLLRTMVDLYKEGRILSIAPAQTFSAHDIKDCFKCMQGGQQMGKLRVSFKERLPKPAFRPKTITLPGNASYLLVGGLGGLGAGLARWMADHKAKQLIFLSRSAGDDAGSYRWLCHELACQGCSVTTVRGSVCNPADVQRAIRSATAPLKGIVNMSLVLRDNSLLKMSLDEWEAATEPKVQGTWNLHRASLDLDLDFFLLFGSMCGIFGMPGQANYASSNSFVDAFALYRRGCGLPASVVDLGAVEGIGYVARNPQVLASSKLIGDVRLSQKELFDALTVAICNGRIPSKGRTGRGFVNQAQVLTSFRSTELWSGKSVLFDNRFASYRVNAADAPLANETATKTNKLAQFVTSAATEYDTLSQPRAVDFVAAQIARAIFDLLMKPVEDEHEIDLWRSLSDIGLDSLAAVELRSWWRVTFGLEISVLEIMSFASCGALGRHAVRGLAESFWPDKADSLVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5E7</accession>
    <name>A0A367L5E7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_3808</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5E7"/>
    <dbReference type="OrthoDB" id="5264002at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI09655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="143" mass="16301" checksum="209C7168B73FBE3E" modified="2018-11-07" version="1" fragment="single">FLATSLREILLALCVTPTPKAPPIISLLSKVSNFTNLFSKEKASALLPYYSSQDYYIRLRYNLDNRIGFLFRSLEGKARKTLETYNPNKFIKAANCLCYLNFSISNSSLLTKTKDNSLSYKDFYSYIKDSKTRFKNSATIAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5K5</accession>
    <name>A0A367L5K5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_4088</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5K5"/>
    <dbReference type="STRING" id="1330021.A0A367L5K5"/>
    <dbReference type="OrthoDB" id="5391043at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF23">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="585"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="591"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="626"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI09502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="888" mass="99824" checksum="0E743564FC7CE088" modified="2018-11-07" version="1">MTMATNVNRLEPMAAALHENDRDDPKGKKPAVKKRTKTGCLTCRKRRIKCDENKPRCKNCIKSKRECEGYNQRVVFKDPMGAQQSHYTPALYPPSLPYLGDPLASHHAKPQAQIPLQAIAPKPSPYSFGHQQQMVTPHQHHGNLDIFSQAHLTAALQPPMPNPLLAPSLASNHEQSIFDIGQQQYDHVPRHHHFLHVDQEPIDANRPLDVDESSFAFPTNTLHSLTENENDAIFLEDEAYLAESDDDHPDPRGLLAPGISHMPWPCPMTDGSQVRTFSAFAREQTLSEYMNFAPNSELRNHAMRTIFMHFISVTGPSMSLYERDPPPNAEPGPFEQNAEVGNNLFSYTFPVLSLNHPGLLHAIMAIASLQIAKIQGTPATAALKHYHLSIRRIAKNVRSPLRRSKLSTLAATLLLAYFEVWSSDHTKWCSHLFGARLLFREIALRDMSRICLPAKRLRWSTGFGTGEAPIDLDYQLLSAITGTQISAEDYGLQEGQPVDQRCLYLTDKDIEQYDILRDLFWWYGKMDVYQSVLGGTKLFMEYDAWTQCPPRGAFSDIHAIYGTYDHLMLLLGRLASFTAKDLARKRKANRNPHSSTSGGSPPQFPGIVPTHGKFRVPMGFSPEMGHSPRTDSNDDPEAHQSLETAEQEWDSIRQGFEALESHLGPQFQHLNSEYTERKETPFGSALQYRTYSVAGIWMNYYMGLIHLYRCRPNMPPAAMQAAQVAAPSTAGYAIQIGRIAAGLADDCSRAVDLSTTLAAAFIESCFCLFVAAVQLQSNDQRCWVVQRMHDISRLTGWQSAKKIANGCESAWLKAYQLGHGPEYKRPENLDDAPVSVWMLPRRLDRRISELDEREETRLVLVKSEQTNLAFGLLGVEGDLDRIELADDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5L1</accession>
    <name>A0A367L5L1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_3833</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the histone H4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5L1"/>
    <dbReference type="STRING" id="1330021.A0A367L5L1"/>
    <dbReference type="OrthoDB" id="3919494at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000012">
        <property type="entry name" value="Histone H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI09688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="137" mass="15245" checksum="858C0C2402EFB1D5" modified="2018-11-07" version="1">MPTKSSRGGPATARALPAKEARMGGKTLMQSKRHRKIARDTIKGITRPDIRRLARRGGVKRISANIYDEVRQALKSHLETILQSCVIYVEHRNAKTITTLDVIHSLSRLGRPVYGFDPATYEPSKKSKKTGVVPETP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5S5</accession>
    <name>A0A367L5S5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_3912</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5S5"/>
    <dbReference type="OrthoDB" id="1720422at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI09780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="635" mass="72908" checksum="1292CA6511F49E8B" modified="2018-11-07" version="1">MSLPPSYIQLLRKACRRYHWCSVVVKPGNQYRAERIPAMPKAIKLSFVHQLHLRLDECDLVDPRCLHWIVPPRPYPKESDGLWSSGEEDEDRLSPLVRIETLRNRVLALLSRFRKDQLMSFSWELGTCLPVDILQRVADRHNGILSLRLATDGHCKELPDPDPIASVKFRDLESFAWSGITDPFAATCFVHRHRSKLRNLDLAMSSHAPFEREKQRANDGFANHIWKENRRQHLAPGQQMLTLRLNRVQKLTLSRMAVADNFLITVFDLKRLQSLTLRDCPGWNMALVAAAAADSEGPIALKTLEIQSKCETWRDEGCESGDWSWLEFFRKTVYLKKFYLGLEVLREENAARIVWEAIDVLCDRLVELVVHFSERSAFEWWPSTFDVKGAGIFDDGGLLGYWNPFNQSILESLGIACVPKHLISLLKPFAETTSLRFLHVRQTKSDVFHQGSYCYAKAEETQAGALLRPGFLDLASWAFGPRGIHSLETIAFGDFASNRPSAGHSLFLVRDHQQSKGYTIVQPSSDKGKRLLSHDKHRRVLSSCPLVKTVEPQHLATMTQRRLQMPPGFYDDGETEYVQCEEEEEEEESDLDIATVENVSGLETPIRRYLRITNDGVEKRRRMNGGFYYRRQDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5S6</accession>
    <name>A0A367L5S6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_4151</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AFG1 ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5S6"/>
    <dbReference type="STRING" id="1330021.A0A367L5S6"/>
    <dbReference type="OrthoDB" id="548867at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005654">
        <property type="entry name" value="ATPase_AFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040713">
        <property type="entry name" value="ZapE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169:SF6">
        <property type="entry name" value="AFG1-LIKE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169">
        <property type="entry name" value="ATPASE N2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03969">
        <property type="entry name" value="AFG1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="498"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="433"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="505"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI09786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="526" mass="58759" checksum="D371C685AD4B9431" modified="2018-11-07" version="1">MMQTLAPPLRRWCLRSSPPRWRPPLRMLALVSAVRCLASVAASSGPLAEYDRRVEAGVLRNDDHQRGIIESLEHLYNELRDYHHPPPPLVRRSPKKLSALPSMLSALFGRSATTTKPAGIGPIPVGLPRGLYLYGDVGSGKTMLMDLFYDTLPSTVETKTRIHFHNFMQDVHRRLHRFKMEHGADVDALPFVAADVAAQAGVLCFDEFQCTDVADAMILRRLLESLMSHGVVLVTTSNRPPDDLYKNGVQRESFVPAITLLKSRLHVINLDSPTDYRKIPRPPSGVYHTPLDSHADSHAEKWFRFLGDPETLEPHPETQRVWGRDIYVPRVSGRCAWFTFGELIGQPKSAADYLELVRCYDAFVVTDVPGMTIRERDLARRFITFIDAVYEGNAKLVLTTEKPLTELFVSRDEMADSLRAANNARAGTGPSATTTTTTTTTTTTEEGAAAVGSIMEDVELSAEKLKSSNLFAGEEEAFAFARALSRLSQMESREWVERGMGLENKGGKQDKESWSKARSRQMEDSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L732</accession>
    <name>A0A367L732_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">E2 ubiquitin-conjugating enzyme</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_8728</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L732"/>
    <dbReference type="STRING" id="1330021.A0A367L732"/>
    <dbReference type="OrthoDB" id="9978460at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000060">
        <property type="entry name" value="Ubiquitin conjugating enzyme (UbcB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="6">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI10219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="163" mass="18084" checksum="7AB1726E1520357A" modified="2018-11-07" version="1">MSSKRMTKEFAEASASPPQGFTVSLDTSSLTRWNLIFAPPQPSAYHPGRYALVMTLPAEYPFRPPTIRFATPVYHPNVTNDSLGNVCLAILKPDQWKPATRLVSVLQAVASLLLEPQPDDPLEESIAEEYRSDRPAWEAKVRAHVKKHAMAEPTFPPEDDAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L797</accession>
    <name>A0A367L797_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_8552</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L797"/>
    <dbReference type="STRING" id="1330021.A0A367L797"/>
    <dbReference type="OrthoDB" id="3918848at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018829">
        <property type="entry name" value="DUF2433"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052743">
        <property type="entry name" value="Glutaminase_GtaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056812">
        <property type="entry name" value="RRM_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987:SF11">
        <property type="entry name" value="DUF2433 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987">
        <property type="entry name" value="GLUTAMINASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10360">
        <property type="entry name" value="DUF2433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25061">
        <property type="entry name" value="RRM_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2433" evidence="2">
        <location>
            <begin position="278"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding" evidence="3">
        <location>
            <begin position="509"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="407"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="570"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="441"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI10291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="669" mass="71005" checksum="EB5992B8B50D265B" modified="2018-11-07" version="1">MAAPRPYNNSAYLQNGATGLAQPGAAPLLPNQGRVIQTGPIRTLCIADVRGNLRSLNELAKQARADHIIHTGDFGFYDDTSLDRIVEKTLKHVAQYSPLISEPVKKAIQQGGNGPVKSRFPPSELPLSELPLLLSGELKLDVPVYTVWGACEDVRVLEKFRSSEYKVPNLHIIDEARSMLLEVGGVKLRLLGLGGAVVMHKLFDNGEGRTTIAGGQGTMWTTLLQMGELVDTAHRVYDPTETRIFITHASPAREGILNQLSVTLKADFSISAGLHFRYGSSYNEFSVNPTLDHYRGKLAASKASFNDVWETVKGEVEPAIQSNEAQQNLLKNALQIVEKMPTTAAGGNPFGGPVAGQAALGQVDESAFKNMWNFNLADAAFGYLVLEIQDGRIGTEMRAQGFNFSHRGAKQQPGAASAPPPADVGSQSSPAPPVTQPAAPPQANRQPPASQPPKAAAATRSGGGTKPATPKPTDNTSGKDMEKTPAAANGSAHGPDLSASPAPKSFSSDIIGLFVMNVGSEDQCRDMFPEEDKSKIVKVDNWGLANKVVHFKTTEERDAALARLPEDIKTRAREDRSKPLVKLFQPREGKPFSNRGGAGQWGGNARGGASGSGYRSAGGTSDSESNRRGGRGGRGGRGGDRSRSGRGRGVMKADAGTSSPATPVTPAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7U8</accession>
    <name>A0A367L7U8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_4451</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7U8"/>
    <dbReference type="STRING" id="1330021.A0A367L7U8"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051616">
        <property type="entry name" value="Cul2-RING_E3_ligase_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46224">
        <property type="entry name" value="ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46224:SF6">
        <property type="entry name" value="ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="627"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="811"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="292"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="38"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="66"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="349"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI10484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1038" mass="112388" checksum="83686617F65C5472" modified="2018-11-07" version="1">MSHDAPVIPPQESIALDFNEALGLNPPLARRDRVSLFPPREAAARPRSSSAAAPFVLRQPLDAPDRPSSSSASTARPSSASTTRSRPPVGHRRDGNMATCGKAQAQCFELCHKIAAAGDAVAERMAEYSSIVKHPPFGFDGLANELLDVCHILFYIEAGLDEAVDNVHPLPLEMITVLERRFRAAQADFKVLDHTVGKWLDNERRGAVGRMRRGLGKVFGKDGIDKMLVSLQRHRAELKMSALMFQWNLGSTRIESDPGIGYISLNSTLEDSNLRRKHESLAFVTADDRASSSSSIYRSKPGSRQRKTDSMLHEPMTQPPGTRDSRNIPFSPDSTSGESALASEFGQGTPATRYTASSSSSHDRPDGLDEVPELSTELAALVADVVGPGLDTLTVDRRQADVSAMPRRRPRSNTEGDKVSSKHALVDAIRTKDHRLVSQLLDRGVSPNTGPDAHAVNESIQTQDHALVDAIRTKDHRLVSQLLDRGVSPNTGPDAHAVNESIQTQDVESLRLLLLYGADPDALDREGLSPLGAAARCSQLCAAALLLKYGADAGMEPPLEMERPLAVAAAANNVRLARLLLMYGGDPNQPTAEGDTVLISCIGKKTPKRLVETLLAHGADPNDKNRDGKTALFDAIQSARVDIVSLLLEKGADPNLPGPKHMLWPATYQPPCVEVLLAHGADHKKCPGIMELATSINRVESVQMLLKAGVDPNAKKDGVYTPLCTSIRDNRGDIFQLLLANGADPNLRASEYPAFKCVTHHREHFLPALVAAGARLNTPKGILETAVSSNNGQALGWLLDQGLDPDEKNGKGYTALTSAVRDDREGFVELLLARGANPNVRGQDWPVCIAVRHPAILKRILETLPEPRAFKGVVEMAVVANQLDSIKLLLAAGVSVEDRNGGVFSPLTTALRERRREIVSYLINEGGADVNAPGEHLPIVKALRRCQDEEHADMIDMLLDKGADPNKMYRGWNGIMQALENGDAAMLARVCSRSGVDVDVKDELGRNVTEIAVSRRWEEAVNILLANATTTKKPEGVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-09-13" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8A0</accession>
    <name>A0A367L8A0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_4443</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8A0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016703154" description="Secreted protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI10641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="100" mass="10727" checksum="162E76748E2FD4F1" modified="2018-11-07" version="1" fragment="single">MCLCLCLCLSVSVSVCLSLSAESWEPPPDRTTPHSGPSISPSLIKKSGDAGTRGTEDAGSEVGKDKIEDALSYQSKSWTLCAYRGCQIFQSNDPVLHQYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8J5</accession>
    <name>A0A367L8J5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5176</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8J5"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI10734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="105" mass="12206" checksum="D682C5164AEEDD06" modified="2018-11-07" version="1" fragment="single">LPEPESLAKEYFWSLPIVAERGNFFKKSKEEGGKKEVEMDKELTNREEAIEEELEAGEVFVLRRYFSRYFKVPTCSTLTYLYKIGNLEEDLYVPYPAVSAVLRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8Y4</accession>
    <name>A0A367L8Y4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 15">Mitochondrial import inner membrane translocase subunit TIM50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">L249_5202</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to direct preproteins in transit and direct them to the channel protein TIM23, and possibly facilitates transfer of the translocating proteins from the TOM complex to the TIM23 complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the TIM23 complex, at least composed of TIM23, TIM17, TIM50 and TIM21. Interacts with preproteins in transit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Mitochondrion inner membrane</location>
            <topology evidence="1 15">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the TIM50 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8Y4"/>
    <dbReference type="STRING" id="1330021.A0A367L8Y4"/>
    <dbReference type="OrthoDB" id="287041at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000019">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit TIM50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7 15" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="10 15" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FCP1 homology" evidence="17">
        <location>
            <begin position="243"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="519"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00063960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU365079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RCI10885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="540" mass="61369" checksum="A9A92B7292C4ABC0" modified="2018-11-07" version="1">MLLRAARAPRLAAVGRLSLCRAYSRKPPKYEPPSPPKASPQGSPQPPRHGSLGAFAANSPAMGKAPQGQQPSPEPPARDAPDASRKPIQPPPEQDSQETEAKPPDITEATPLHKLPDLTRGIPSTLEQEMREKAVRSSSALQTVDAKGRGRRERRETYIPSSERNRSWWIRFMLLATAVGSSYGIVYMGRNWKDAAEAERHPEAPNGWSLRLWWQRVKVRTGESVSYYQDPAFEKLLPDPDPSFERPYTLCLSLDDLLIHSEWSREYGWRIAKRPGMDYFVRYLSQYYELVLFTTVPFSYAEPLVRKLDPFRFIMWPLYREATKFEDGEIVKDLSFLNRDLSKVIIIDTNPSHVRKQPHNAIVLDPWKGDVKDKELVSLIPFLEYIYTMQHPDVRKVIKSFEGKHIPTEFARREAIARREFNKQLEAQKSKYSKASGMGALGSLLGLRPEKMSMTVPADGEQNPVEAFAQGKMLQDLARERGQRNFALLEQEIQKNGEKWLKEEQVAIEKAQKDMVNNTLGTLSEWLSSPPKPEPGGGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L905</accession>
    <name>A0A367L905_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">WH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_5222</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L905"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016836536" description="WH2 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI10896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="24522" checksum="1184D9F0E1B3154B" modified="2018-11-07" version="1">MRAETITLLLTVLAGSALAAPTPGWKNTIARREAEPSRNDGLHFAAIEARSEQQNEAEDDDGGDKAIIEKRRLLLRRTKPAQAKPVDTKPSGTGLQKVEQAIEKLTGNNNKKPGGTGSNRKRQLERRGGTGQLMGKPSTAMSGTLKLVKRQFHPGAPLPPGVVIGPPPPGVAIGPPPGAFDPSLQGPPPQGLPPPVFMPGPTFMPGSFPGFAKRSEVGVEAAAAQSNPNGNGKGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9K9</accession>
    <name>A0A367L9K9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein bL27m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_7708</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9K9"/>
    <dbReference type="STRING" id="1330021.A0A367L9K9"/>
    <dbReference type="OrthoDB" id="1867012at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000042">
        <property type="entry name" value="50S ribosomal protein L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_bL27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL27M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="RIBOSOMAL PROTEIN L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00063">
        <property type="entry name" value="RIBOSOMALL27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="228"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI11113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="262" mass="30328" checksum="6A12E21FF39F18FB" modified="2018-11-07" version="1">MSLLCLFRRPLIRTSNGPLAVQGRRQASVKSQGAYKKKNKRTTPKKLGAKKTGDQFVIPGNILFKQRGSVWWPGENCFMGRDHTIHTKVSGYVKFYRDPEKHPDRKYIGVVFNKEDKLPYGRHAERKRRLGMVAHPRVVATGPTEKLSPSGIPYEVLRVQPGEPERLLRLRDNYSYREDNWRIGKLVKTTAIRMGRFRTRKQSYRFRRWMRERQRLGLRKAKLKLSLEGGEAGSRPAAQIVSKKAAKRAAKLARHDKAAKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAG5</accession>
    <name>A0A367LAG5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Ornithine decarboxylase</fullName>
            <ecNumber evidence="11">4.1.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">L249_7684</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-ornithine + H(+) = putrescine + CO2</text>
            <dbReference type="Rhea" id="RHEA:22964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:326268"/>
            <dbReference type="EC" id="4.1.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homodimer. Only the dimer is catalytically active, as the active sites are constructed of residues from both monomers.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the Orn/Lys/Arg decarboxylase class-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.17" evidence="11"/>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAG5"/>
    <dbReference type="STRING" id="1330021.A0A367LAG5"/>
    <dbReference type="OrthoDB" id="5034579at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004586">
        <property type="term" value="F:ornithine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033387">
        <property type="term" value="P:putrescine biosynthetic process from arginine, via ornithine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00622">
        <property type="entry name" value="PLPDE_III_ODC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.37.10:FF:000010">
        <property type="entry name" value="Ornithine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000005">
        <property type="entry name" value="Ornithine decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.10">
        <property type="entry name" value="Lyase, Ornithine Decarboxylase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009006">
        <property type="entry name" value="Ala_racemase/Decarboxylase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022643">
        <property type="entry name" value="De-COase2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022657">
        <property type="entry name" value="De-COase2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022644">
        <property type="entry name" value="De-COase2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022653">
        <property type="entry name" value="De-COase2_pyr-phos_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000183">
        <property type="entry name" value="Orn/DAP/Arg_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002433">
        <property type="entry name" value="Orn_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482">
        <property type="entry name" value="ARGININE/DIAMINOPIMELATE/ORNITHINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11482:SF6">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02784">
        <property type="entry name" value="Orn_Arg_deC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00278">
        <property type="entry name" value="Orn_DAP_Arg_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01179">
        <property type="entry name" value="ODADCRBXLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01182">
        <property type="entry name" value="ORNDCRBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50621">
        <property type="entry name" value="Alanine racemase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00878">
        <property type="entry name" value="ODR_DC_2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00879">
        <property type="entry name" value="ODR_DC_2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="7 17" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0702">S-nitrosylation</keyword>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 C-terminal" evidence="19">
        <location>
            <begin position="71"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Orn/DAP/Arg decarboxylase 2 N-terminal" evidence="20">
        <location>
            <begin position="75"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="17">
        <location>
            <position position="383"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="17">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00066100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR600183-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF02784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RCI11404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="446" mass="48893" checksum="2DE81E6175EB3C5F" modified="2018-11-07" version="1">MATVLVECQPPAVVVVDHVVNKKQQQTQVTTAQVQDDTTMDAKTLIGEALDRRVSSINHDECSPGDEDTFYVADLGHVYRQHLGWKKHLPRVKPFFAVKCNPDPQVLRLLAALGTGFDCASKTEIEQVLGLGVSPDRIIYAQPCKTTSYIRFVRSAGVKQMTFDNADELYKVAKVFPEAELFLRIATDDRSSLCRLSIKFGAGMESTPYLLGLAKSLGLNVVGVSFHVGSGASDPQAFYKAVRDAQVVFRQGRAMGLGLRTLDVGGGFCGETFPRMAGTLAKALDDFFPGGDVDIMAEPGRYYVSSAFTVACNVIARRAVDDKGYMIYVNDGVYGNFSSIMFDHQQPLARILRTGGKTVYDTDESRPSLPGTGVEYSVWGPTCDGIDRISESVNFYSVLDVGDWLYFEEMGAYTRCSATQFNGFRNAHDVIYVCSEPGARALISDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAQ0</accession>
    <name>A0A367LAQ0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein L1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_7628</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAQ0"/>
    <dbReference type="STRING" id="1330021.A0A367LAQ0"/>
    <dbReference type="OrthoDB" id="1747252at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36427">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36427:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL1M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI11322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="34545" checksum="A25D2F1FE4AC9EE7" modified="2018-11-07" version="1">MAPIDRRLASMAGTSLSRVTRPPATSLPLVQCRWGSKDKNKLKGRAKDNAKAKNNHANAWNAKPAVKDKAKRLTPLDFKRPDLEKYGFPQYSLCEAMRIIRAAEVGQPPTLAKYELHITLQTPRAGAVIKGSIQLPAPAQNDWQIAVICPEGSQAAIEAAAGGAVAVGEEVIFEAVRNEQINFDRLLCHELSESKLKKANLGRILGPKGLMPSVKMGTMVNNVAKAMKESASAVEFRERVGVIHTTVGQLSNTATQLRDNIQALVSNVKRQCARITEEGTHKKIHEIVLSSTWGPALSLSGRVTDEGDTVSEQDVSGAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LB40</accession>
    <name>A0A367LB40_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_7651</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LB40"/>
    <dbReference type="OrthoDB" id="4865510at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009101">
        <property type="entry name" value="Gurmarin/antifun_pep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024206">
        <property type="entry name" value="Gurmarin/antimicrobial_peptd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11410">
        <property type="entry name" value="Antifungal_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57048">
        <property type="entry name" value="Gurmarin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0929">Antimicrobial</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0960">Knottin</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI11624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="138" mass="14875" checksum="CD8E7FA160DAE179" modified="2018-11-07" version="1" fragment="single">MDFIYEASNVYNNIYDIIIIIIIIIIIMKAVFAFVTVLAGMAVASPGAESIKRQCLPNGSACRADGSMGNCCSGYCSQAAGAPLVSDEELMARKRREQNMSNHDDSLTYGTGISCMYPSVICYNRSGITLVAESSLHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBD1</accession>
    <name>A0A367LBD1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">glutamate--tRNA ligase</fullName>
            <ecNumber evidence="5">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Glutamyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">L249_7619</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26 27">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>tRNA(Glu) + L-glutamate + ATP = L-glutamyl-tRNA(Glu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="5"/>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBD1"/>
    <dbReference type="STRING" id="1330021.A0A367LBD1"/>
    <dbReference type="OrthoDB" id="10250478at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015103">
        <property type="term" value="F:inorganic anion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046685">
        <property type="term" value="P:response to arsenic-containing substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1530.20:FF:000009">
        <property type="entry name" value="Arsenite transporter, ACR3 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1160.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.800.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000037">
        <property type="entry name" value="Glutamine--tRNA ligase cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.240.10:FF:000004">
        <property type="entry name" value="Glutamyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1160.10">
        <property type="entry name" value="Glutamyl-trna Synthetase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.800.10">
        <property type="entry name" value="Glutamyl-tRNA Synthetase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02076">
        <property type="entry name" value="Glu_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004706">
        <property type="entry name" value="Arsenical-R_Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004526">
        <property type="entry name" value="Glu-tRNA-synth_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020061">
        <property type="entry name" value="Glu_tRNA_lig_a-bdl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00832">
        <property type="entry name" value="acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00463">
        <property type="entry name" value="gltX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF5">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="14" id="KW-0059">Arsenical resistance</keyword>
    <keyword evidence="13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0436">Ligase</keyword>
    <keyword evidence="17 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16 22" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="670"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="700"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="739"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="772"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="800"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="833"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="877"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="908"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="970"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="23">
        <location>
            <begin position="115"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding" evidence="24">
        <location>
            <begin position="424"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA synthetases class I (E and Q) anti-codon binding" evidence="25">
        <location>
            <begin position="532"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="626"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="21">
        <location>
            <begin position="637"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00030865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF20974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="RCI11733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1003" mass="112440" checksum="E4E85D67D0D89D76" modified="2018-11-07" version="1">MKDAELEKLWTKLSGDFRSIEPHLRDLDKHLTLRSHLTGYSLGDVETKTWQTLRANKVAMGSIRKNGLPNLTRWFTFIEQSNPQIHEASKSADAAAKKPGGANYNLALQDTDKGVVTRFLPEPSGYLHIGHAKAALLSDYFGHVAYKGKMRLRLDDTNPSKESEEFQDAIVEDLALMGIKADSLTYTSDYFDYLYDMCRKLISMGKAYADDTGLETMRAQRMDGIPSKRRDRSVDENLRIFEEMKKGSDEGLVNCIRAKISADDPNKALRDPVIYRCNVKDAHHRTGRKWNMYPMYDFACPVVDSHEGVTHALRSTEYTDRNPQYQWFLDTLGLRQVHMWDFSRINLIKTFLSKRKLAKLVESGKVWGWDDPRMPTIRGVRRRGMTVPALRDFILRQGPSRNVVVMDWTSFWNTNKKEIDPVVPRHTALLAKDMVKAKLTGSDVPSGVVVEQRPKHPKNASVGTKDLVLSSEIYLDQVDAKSFAVGEEVTLMGWGNAIVRDPPASSSSERDAVKTMTLELNLKGDFKATEKKVTWLSAQGLDLVPAELWDFDYLITKDKLEEEDKVEDFLNPVTATMEEARCDGGVGLLKADDIIQLERRGFYRVDKGLKDWKGDEAGIIMTREAKQDPSPIEEADATEHRRQQQHHGHDLPCPPSKSAFRELGLLDRFLALWILLAMLVGIVVGNFAAGAERVLQQGRFIGVSIPIAVGLLVMMYPILCNVRFESLHLVLRQKRLWRQLGFSLVINWLIAPFFMLALASAFLPDQPGLRKGLMLVGLGRCIAMVLIWNELAGGDGEYCAVLVAVNSLLQLLLFAPMAIFLIGVVRHDDGVRLLTYSVVASSVGVFLGIPLAAAVATRLSVRKLAGERWFDDVFMRWLSPWSLIGLLYTVVVLFAAQGRHVVHQIVSVVRVAAPLVVYFMAIFFGALWATRRLGFGYRLGCAQSFTAASNNFELAIAVAVATFGPDGDEALASSVGPLIEVPVLLTLVYLVRGIGRRWDWREG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBD2</accession>
    <name>A0A367LBD2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Prefoldin subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_7615</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBD2"/>
    <dbReference type="STRING" id="1330021.A0A367LBD2"/>
    <dbReference type="OrthoDB" id="6375174at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23156">
        <property type="entry name" value="Prefoldin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000001">
        <property type="entry name" value="Prefoldin subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016655">
        <property type="entry name" value="PFD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="226"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI11740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="249" mass="28487" checksum="CDE71612FE46934E" modified="2018-11-07" version="1">MLTLRLGEGGPTCFTEHRQESRCVQNAREPPTFFVTSSPAVGGKKWQAQARRRRQDAAPTNPRGIPYAPFVDQVEDYVATRQDVEATLQSFQEMISKYQFMEMNLQRRMAGLKDKLPDIQKTLDAVRFLKARKDESDPIETTFEFNDTLYAQAKIPPTDEVYIWLGANVMLSYPIDEAETLLNSKFKTAKSSLSNCEEDVDFLREQITTMEVAIARVYNWEVVQKRKEKASEEEEAKAKKKDGEASPDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBF3</accession>
    <name>A0A367LBF3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">tRNA dimethylallyltransferase</fullName>
            <ecNumber evidence="5">2.5.1.75</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_7678</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>adenosine(37) in tRNA + dimethylallyl diphosphate = N(6)-dimethylallyladenosine(37) in tRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:26482"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="EC" id="2.5.1.75"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the IPP transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.75" evidence="5"/>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBF3"/>
    <dbReference type="STRING" id="1330021.A0A367LBF3"/>
    <dbReference type="OrthoDB" id="775260at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00185">
        <property type="entry name" value="IPP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018022">
        <property type="entry name" value="IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00174">
        <property type="entry name" value="miaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088:SF89">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01715">
        <property type="entry name" value="IPPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="432"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="436"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI11760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="461" mass="52076" checksum="765F5E0A089564AE" modified="2018-11-07" version="1">MTPARNPPTKPLLVVLGSTGTGKSDLAVDLASRFDGEIINADAMQLYKGLPILTNKMNPSARRGIPHHLLGHIPPLSPPWNVDVFRREASLVLEDIRSRGKLPILVGGTHYYLDALLFPDVVLDSLDQRDGNNHHHDHHPHHGLLDEPTHILLAELRKCDPAMAERWHPNDRRKILRSLEIFLNTGRTATALYAEQEQRRRAAHQNVGPWDKLLFWVHTDRDVLCHRLDRRVDAMLEAGLLDEVRQLYALRREALDPSSVDVTKGIWQSIGYRQFEPYVHDTASSPALKATALEEVKAATRRYAAHQTRWIRYKQTRRLRDQGPEAISSLYLVDSTDPALFRARVLDPAASLVDQFLRGLPRPSPADLSPRAREILAAAWHPPDPPEPPRKHFCDLCQATLLSDEAWRRHIGGIAHRRATVKKKKLALVSCEPQETTRTTTKATTPEAEDRSSSPDITSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBK9</accession>
    <name>A0A367LBK9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBK9"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="96" mass="10432" checksum="0D7B3BD25A70B887" modified="2018-11-07" version="1" fragment="single">HSAYSGVGSIRSIGLTRTSLPPNHRSSKYVRVLQVGTLKYLEKIISISFSHLLNTNTSPASNSSLIASFRLSRDSSSSSLSRNHLPDSSTLYPLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBV5</accession>
    <name>A0A367LBV5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ELMO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_4203</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000009">
        <property type="protein sequence ID" value="RCI11896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBV5"/>
    <dbReference type="STRING" id="1330021.A0A367LBV5"/>
    <dbReference type="OrthoDB" id="28413at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024574">
        <property type="entry name" value="ELMO_ARM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006816">
        <property type="entry name" value="ELMO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050868">
        <property type="entry name" value="ELMO_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771:SF56">
        <property type="entry name" value="CED-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771">
        <property type="entry name" value="ENGULFMENT AND CELL MOTILITY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11841">
        <property type="entry name" value="ELMO_ARM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04727">
        <property type="entry name" value="ELMO_CED12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16457">
        <property type="entry name" value="PH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51335">
        <property type="entry name" value="ELMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="2" id="KW-0581">Phagocytosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0729">SH3-binding</keyword>
    <feature type="domain" description="ELMO" evidence="6">
        <location>
            <begin position="246"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI11896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="693" mass="76630" checksum="92C8062B5EC17C40" modified="2018-11-07" version="1">MDQADIPDLLSRLSSDQDAVRKMAVFKLQNSISDPAFADVFISAGGLVLLRRLIMTSGGNTLAYSLQSLTRLLEVDMGWDMFQGPLATDLVERAVELIVTNPLVNILRGAMAILVALVGHSESGASASFGFRALKPAVAVHPRFFELVVQQLQSADHALCANALMLINALMRDALAATPSPADTGAEDWTKLVRRLQDLGLVQTVYKLMQSSALHDLALPLVEFQSLTRALTSRWRRLPVDLERPEHRRSLKSIHLASVAPGQQQQQELNATAAAATTATKDSRRHNADKWRRLGFETENPARDFHSTGYLGLMDLADYARKHGDAFQKLLLEQTVRPEEERCPVARASICVTAMLCRHFDVDKADPADKAARAATDAKNQEELLRPPLLQWSRLHAVGLQSFLRIWKATGARQDDLDKVAEVVRILLEQVVGGAGRTRSILEIEDEMLEYDLDRLREAQMGLLEAAFEGAWGQHLHRVREVLRREALQFVKEQRVRCLLEGSWFAVREQPGADSSSSTPSDARGWRFARLSHNRRYLHYGDFEVQAPAHEAPGLDGLTERLDLGTISSVVSNVTMSMTSEDGKSTVSNRSTAAQKGKAAATTKITIYGEQTTLTLWPESQSLASEWLDGLLLLLNQAPITAETTKLVDLVSDYGLRMRLLNVRMDTAFAGPPAGAGVVPSREGLDEDYFFEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBZ3</accession>
    <name>A0A367LBZ3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_7674</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LBZ3"/>
    <dbReference type="OrthoDB" id="4927316at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026003">
        <property type="entry name" value="Cohesin_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055496">
        <property type="entry name" value="DUF7068"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312:SF2">
        <property type="entry name" value="NUCLEOTIDE-BINDING OLIGOMERIZATION DOMAIN-CONTAINING PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12765">
        <property type="entry name" value="Cohesin_HEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23238">
        <property type="entry name" value="DUF7068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NACHT" evidence="2">
        <location>
            <begin position="458"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI11752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1701" mass="192641" checksum="803F9B7FBD9D0A67" modified="2018-11-07" version="1">MEPINLDRAVASTGLAIPYQPLRHLSLTVTVSCLLFGAVICWHLFRDKTGSKPTSSPSTSAPAASTEGGVRLTEIDLGRDETNTDLDIIAVHGLDTTSEVTWTWKDGKDPRNKEKWVNWLEAPDMLPSVDQHARIYTCDWPAPLLEPSGLVQMSVQEYIHLLLDGVQRALFGDGTARDEDRPILFIASCLGGLILAKALVKADEKGSDYHRLRRATRGIVFLATPFRGTSFQDVATWALLGLNIRASVRRQAVSSLLDSCKGSTADLRELVRRLTKICQDEEKPLEIFNFYERASTSLPHKVFPWLPACFGQNKPLVDAESASLDITEPLPLDRRHSVMNKFPGTDCADYQKVAGQISRITIRIRAGTPLEQADAWMRTTCYSEERLQIERLSGETLQMAQCYINLAVIQRQRDQNEPSENSPFSLFARLNVETPDETAQVDLAAIFDDRQGRIIRPRRILIRGSAGVGKTTLCKRMVHDFTHDVKSGLHRSWNKLYDRLIWIPLRRLKTTLDRPDRCNFEDVFYDLYFSDKEPDRGRYLARQLWRNLDRRGRDRTLFILDGADEIADDLHGCNNKSEFLQNLFKKDNVIITSRPYFTMPVLRDVDLELETVGFFPDQVKEYVKTTFNDQAITSDIENFLNTHSLVEGLMRIPIQLDALCLAWENLDSETVLDTMTSIYRVITQRLWTKDFKVMSKRNLPGIPGTVSGVGVSDVHRFVNPEIKLLEDVAFTGLINNVIEFSPTHQRKMMDQFPYKREGSEMPISMAFPCLSFLRSSDKSKSQHDLSFHFLHLTFQEFFAAQYFVRHWKSRAQMTCLNLSENEMKQMTPVEFLQKEKYSARYDVFWRFVAGLLVPDGCGQDQELLDFFQAVEQPPLDMLGPTHQRLVMHCLSEVSMEKETVRRRLEDEFGLQGKLKQWHLFECSVGVPILVKEMEFPTQVLCEIFRENPDNVDWRSTLYALSRKPAIPPMIYEEIILWLEDSTSSDSKCEALEALAILDAGLTENITMTVVRRLDDPDERVQEEALDVLATQTSLSDEILTAVIRCLDNGNEHLHFAAVNVFGRQERLSAEISRLIVQRLNDHGSGVRAAAVEALGKQPNLSDETMGTIALRLCDESSNVRKVAIKALGKQPKLLDEMMGTIALRLGDESSDVRKVAIKALGKQPKLSDEIIGTIVLRLGDESSYVRKVAIKALGKQPKLSDEMMGTIALRLGDESSNIRKVAIEALGKQPKLLDEIIGTIALRLCDESSNVRKVAIKALGKQPKLSDEIIGTIALRLYDESFYIREVAIEALGKQPKVSDEMIGIIALRLGDESSIIRKVAIQALEKQPSLSNEILMAVAERLGDKGSYIRIAATGALRKQVKRSDETLTVVTQQLQHDDIRVQHSAAEILLERQHDDALAAIRRLLKDEQPARRRFALRVLKEQPSLSDDCVIAIAQRLDDADLFVRLEAMNICRKQEKLSGEALDSIARHLWGKEEMSVRTEATIKRGLQRAIGDNMSSIAQLLDSFDKFDKWTAFYYLEEDDDLSGETLAALTQRLDALTQRLERGDDLAREENSRVLKVLEKQRFISDETLTSVTRQLGHENFDVIMRAETVLRKHKSFYSALLGGSCAGQLYRALFEWAQDSQFSWYVEGNRSVLNTPEGVMSAKMDDMEGFEASISEAMQTLRRALTDQSLRWERMITSISFVFETLESRIRGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCD0</accession>
    <name>A0A367LCD0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_0731</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCD0"/>
    <dbReference type="STRING" id="1330021.A0A367LCD0"/>
    <dbReference type="OrthoDB" id="423559at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16449">
        <property type="entry name" value="RING-HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF16">
        <property type="entry name" value="ATP-DEPENDENT HELICASE ULS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="434"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="780"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="980"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="52"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="203"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="852"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="203"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="224"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="252"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="862"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="907"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="927"/>
            <end position="937"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI12074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1149" mass="128458" checksum="EC8E8A0847A0265B" modified="2018-11-07" version="1">MAQPLDSVSLTEELTVQQVILSSLEGEDLPNIEESREEARKEITRIKALLDQLSQEKANNGQDTSSLPDQPHADTTAGSSPLQASSAATEDTPSSVARCHASTAFSTPPRRVMNSWKSPSASALSSRKRGRQSPDLDDVFSPLRSAPRYEQPHPFQGLGSNAIEFIDLTGDDVDSNSFCVAEQVKQEKRSEQEMKDRDLALKLSTQSSSSPGLPSPAPASGSGHTNAFSKMMATQQSNAHRADSGWDWSHTPDAQSQRGSSLNSPSAVMPGTWTDDTDYMGPGSHAFAAQAAFGDSLRNAYLPSNPQAYPPSSTQSPYSVLPSFAQNQARNPASSFGSFGLPSWPNMHDVLDRTGMFDYASRMDAEGNPFSERLTSYLQHVYHDPQVTEKELDDLLNNIRPDMDIPQGNRDGTPAGLKDQLYRHQELALTWMKKMEQGTNKGGILADDMGLGKTISTLALILARPPAAGLPKTTLVVAPVALVRQWQDEILRKTRASHCLSVFIYHNRKTTVDELLRYDVVLTTYGTVAQEHGRYEKFCLENRGRSIDMNDRATASKFPLLHPTKAKFCRVVLDEAQLIKNRKTKTAKACNCIQATYRWCLTGTPMMNSIVELYSLVQFLGIKPYCVWDKFRHDFGALFGARRCESQDNAMNRFRALLKAIMLRRKKDSKLDGKPILNLPRKTETIVHAKLSPDERGFYRQLEEKSQVQFSKYLRDGSVGKNYSNILVLLLRMRQACCHPHLHVDVDDAGTVSSEAINEGVKNLSKSVVERIKAIEAFECPICFDAVQSPSFFVPCGHDSCSDCLARLLDNAAATNLQDGNESDLVKCPVCRSPFDPRNCFSLEAFRSVHMPETVVKKPESDGEEPDDDDDDDDDDDDDDDDDDDDDDDFPSDDDVDTNGNLRDFVVPDDDFGDDDTEPKRVAASAKARRKARRGKRKQVDVRPTALRSLRQEAMRNREAHKRYMRYLRKTWMPSSKVTECMELVKKVEEKGEKAIVFSQWTLLLDLLQVAMQREGLKPPERYDGSMSGDERAAAARNFGMDSRVRVMLVSLRAGNAGLNLTAASTVIIMDPFWNPYIEMQAIDRAHRIGQQREVTVYRILSEETVEDRIVELQMRKKDKVEAALDESESMKIGRLNVNELKFLFNTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCG3</accession>
    <name>A0A367LCG3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0944</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCG3"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="300" mass="32803" checksum="52277A84CB016108" modified="2018-11-07" version="1" fragment="single">MQLYRDPSSMTGSQRRSRDLLPQIQGAHTTLHGSDRMASFNNLLERRLLQTIIGYDGCISHDVTRSSPSQYEQQKTGKKTTIDGSGCVNFTDLPISSKERKRGRFGFRRELSVDTEKRPARGNQGGKRKSWLTAATQGAGGIASSVESSQSTERGPFDANEKEGRDVIIRRDGTQAYMYDISICLFGREEKRRVERRGANGEMLCEATSGTRPLRADTSFFVRRVGVAVPWFVAAPDRGLCAVECAKAEVVCSVKGGMSMDRGQQGNRSSSSSSSKAQFPGLSICVSHVIFGGVSDASVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCH5</accession>
    <name>A0A367LCH5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Malate dehydrogenase</fullName>
            <ecNumber evidence="3 12">1.1.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L249_0719</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 12">
            <text>(S)-malate + NAD(+) = oxaloacetate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21432"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.37"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH/MDH superfamily. MDH type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.37" evidence="3 12"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCH5"/>
    <dbReference type="STRING" id="1330021.A0A367LCH5"/>
    <dbReference type="OrthoDB" id="4069699at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030060">
        <property type="term" value="F:L-malate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01337">
        <property type="entry name" value="MDH_glyoxysomal_mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000013">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000001">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001252">
        <property type="entry name" value="Malate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010097">
        <property type="entry name" value="Malate_DH_type1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01772">
        <property type="entry name" value="MDH_euk_gproteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540">
        <property type="entry name" value="MALATE AND LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11540:SF73">
        <property type="entry name" value="MALATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00068">
        <property type="entry name" value="MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 12" id="KW-0520">NAD</keyword>
    <keyword evidence="5 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="13">
        <location>
            <begin position="19"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="14">
        <location>
            <begin position="164"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="194"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="24"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="134"/>
            <end position="136"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCI12126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="334" mass="35315" checksum="D24184F6B02EB00B" modified="2018-11-07" version="1">MASFIQRRAFSASARNLSKVAVLGAAGGIGQPLSLLLKMNPRVTDLALYDIRLAPGVAADISHVNTKSSVKGYDPTRSNLAACLKGSDIVLIPAGVPRKPGMSRDDLFNTNASIVRDLAKAVAEYAPEAKVLVISNPVNSTVPICAEVFKTKGVYNPKTLFGVTTLDVVRASRFVSEIKGTDPKDENITVIGGHSGVTIVPLFSQSKHPDLSSDDDLIHRVQFGGDEVVKAKDGAGSATLSMAMAGARMADSLLRAADGEKGVVEPTFVDSPLFKDQGIDFFSTKVELGPDGVEKILPVGKVDKVEEKLIQDCLGGLKSNINKGITFVKENPGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LD03</accession>
    <name>A0A367LD03_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-alpha-acetyltransferase 40</fullName>
            <ecNumber evidence="4">2.3.1.257</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_0271</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-seryl-[histone H2A] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[histone H2A] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50600"/>
            <dbReference type="Rhea" id="RHEA-COMP:12742"/>
            <dbReference type="Rhea" id="RHEA-COMP:12744"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.257"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N-terminal L-seryl-[histone H4] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[histone H4] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50596"/>
            <dbReference type="Rhea" id="RHEA-COMP:12740"/>
            <dbReference type="Rhea" id="RHEA-COMP:12743"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.257"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. NAA40 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.257" evidence="4"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LD03"/>
    <dbReference type="STRING" id="1330021.A0A367LD03"/>
    <dbReference type="OrthoDB" id="424551at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043998">
        <property type="term" value="F:histone H2A acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010485">
        <property type="term" value="F:histone H4 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039949">
        <property type="entry name" value="NAA40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20531">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20531:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="12">
        <location>
            <begin position="50"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI12295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="215" mass="23963" checksum="7794A0BF2689A5AE" modified="2018-11-07" version="1">MSKEAEEAIEEANSLSDEEFLQRLIHPSPESSWPEWTHPQTGATYHLRLTRTEALTEKEVDDCLALVQQTSGDAYRASANGWRPGAKRREMRTAGLRYVLVRGDRHHGPLVGFVSMMLTWEAGEAVVYCYEIHLEALLRGSGLGTMLMGFVASVARRTPHVAKVMLTCFTSNSRARAFYSRLGYGVDASSPRETRELRGGRTVGSQYVILSLVVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDM0</accession>
    <name>A0A367LDM0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61</fullName>
            <ecNumber evidence="1">2.1.1.220</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">tRNA(m1A58)-methyltransferase subunit TRM61</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_1181</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.220" evidence="1"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDM0"/>
    <dbReference type="STRING" id="1330021.A0A367LDM0"/>
    <dbReference type="OrthoDB" id="5585464at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160107">
        <property type="term" value="F:tRNA (adenine(58)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133:SF1">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="393"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="394"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="422"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00033309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI12528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="460" mass="50217" checksum="DF3D0D4067480BC5" modified="2018-11-07" version="1">MAKRHVSRLTFLLTPPRVRTLSTVSVVQEHDVVLLRQQGPKSPRWHLTAPLRCGSQIKLSYGRTVKVDHLLGRRPLDRVVDSAGLPVVVHEPTLSCYVLHSSFTRLATPIYPHDAGTIVSLLDIHPVRPGEEEEDDDGDSVGPPLEVFEAGTGVGSLTLHLARALHAANPPLPPTLRRALCAAHACRDPETVSADLGPEDQAALDVYKASRRLVLHTLDQSVSRAKAAFKFVRHFRRALYLPTIDFHVGTVDSYISQRLVASEGRPFLSRAVLDLASPEESAAPVVQALHPGAVLIIFQPSISQIANFQAWCRETSQPLQLDKVLELPATTVMHGLNDNGGGRPWTVKMGTVKADGGKAVQIMRPKVGGSMAGGGFVAVFRRWPVDGMSVLAPEEADESESPAESEREKEPNQAQMGIPQAQKDNQQNETKYPQQAQKDEQDETKPQQAQTDDGIEVSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDM4</accession>
    <name>A0A367LDM4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_1187</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDM4"/>
    <dbReference type="STRING" id="1330021.A0A367LDM4"/>
    <dbReference type="OrthoDB" id="783096at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07383">
        <property type="entry name" value="MPP_Dcr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000054">
        <property type="entry name" value="DCR2p Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440:SF0">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32440">
        <property type="entry name" value="PHOSPHATASE DCR2-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="3">
        <location>
            <begin position="211"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI12533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="585" mass="64865" checksum="BC9D86B0E9410CA3" modified="2018-11-07" version="1">MARRILRTAVQLCAAVFFTLVVIFLLDRNYRVLPNAIHGYMPLHHPGLVVTDMTIAFCSSVNIFSSCDLDPQVWHRIDKDLFMGQAWTSSAYLYMRRKHENELTADDGVVMDVTVARVDPSVQNEWESRPGGLWIKRSKEKKSTDSKDVVTNVDVLFGDDAVEARYGWGIVGTPMRLNTGPSFLSVHVTVHRGSPKEPKKPKPRIPDNGRFKIMQIADLHLSNGVGECREPIPNSYAGGKCEADPRTLDFVGKMLDEEKPDFVVLSGDQVNGGTAPDAPTAIFKYASMLSKRRIPHVGIFGNHDDEKTMSRARQMALMETLPYSLSTAGPAEVDGVGNYYVEILARGGSDHSALTIYLLDTHAYSPDERKFPGYDWVKPKQIEWFKRTAASLKKKHNEYTHQHMDMAFIHIPLTEYADWELPRVGEWREGVTAPMYNSGFRDALAEEGVVMVSAGHDHCNDYCSLSLSGDRDPKKKKPLTPALWMCYGGGVGFGGYAGYGEYVRRVRLFEVDTNNARITTWKRLEYGNTAAHIDQQIIVDGGRPVAPPAPPPPPQGQAAPRPAAPPPPPPPPPPPAPPFQPPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDP7</accession>
    <name>A0A367LDP7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDP7"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="139" mass="15877" checksum="E73F1D39A3E16673" modified="2018-11-07" version="1" fragment="single">EIRIELYSGLRVEYYSTKRGLAIRRYILAALPAIIAPYSSGTILTLVNNPPIDRDLIFFPNSLLLSGSIIRDCFYITVFNSSNCLISFKRKEKISDPVPPINIPDPIPNIPEIEGEYSVKIYTLNYNLAFKSYYSSYRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LE84</accession>
    <name>A0A367LE84_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PABS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_1064</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the spermidine/spermine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LE84"/>
    <dbReference type="STRING" id="1330021.A0A367LE84"/>
    <dbReference type="OrthoDB" id="38125at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004766">
        <property type="term" value="F:spermidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015940">
        <property type="term" value="P:pantothenate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008295">
        <property type="term" value="P:spermidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.140.10:FF:000001">
        <property type="entry name" value="SPE3p Spermidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000013">
        <property type="entry name" value="Spermidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.140.10">
        <property type="entry name" value="Spermidine synthase, tetramerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00198">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030374">
        <property type="entry name" value="PABS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030373">
        <property type="entry name" value="PABS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001045">
        <property type="entry name" value="Spermi_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030668">
        <property type="entry name" value="Spermi_synthase_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035246">
        <property type="entry name" value="Spermidine_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037163">
        <property type="entry name" value="Spermidine_synt_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002010">
        <property type="entry name" value="PRK00811.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00417">
        <property type="entry name" value="speE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558:SF11">
        <property type="entry name" value="SPERMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11558">
        <property type="entry name" value="SPERMIDINE/SPERMINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17284">
        <property type="entry name" value="Spermine_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000502">
        <property type="entry name" value="Spermidine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01330">
        <property type="entry name" value="PABS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51006">
        <property type="entry name" value="PABS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0620">Polyamine biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PABS" evidence="5">
        <location>
            <begin position="14"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI12731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="301" mass="34229" checksum="8A6F070C3F046CB8" modified="2018-11-07" version="1">MSENGKIEHPTIKDGWFREMNEMWPGQAMMLKVDKVLHHEKSKYQDVLAFKSTNYGNVLVLDNVIQCTERDEFAYQEMIAHLPLCSHPNPKKVLVIGGGDGGVLREIVKHDCVEEAVLCDIDEAVIRVSKLFLPSMAEGLSHPKSTVHVADGFKFLEEYKNTFDVIITDSSDPEGPAENLFEKAYFQLLYDALREGASSAPKVVGPISSENQWLHLPLIQKLRKNCREIFPVAEYAYTTIPTYPSGQIGFMICSKDGSRDVKKPLRRWPEEEEYKLFRYYNAQIHEASFILPNFAKKGLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LE85</accession>
    <name>A0A367LE85_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_0507</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LE85"/>
    <dbReference type="STRING" id="1330021.A0A367LE85"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF49">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI12726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="497" mass="53903" checksum="8855AE15A3608677" modified="2018-11-07" version="1">MSHGEKDAEPASPVSGGDEKKLVRKQDSRLIPLSAAIYFLCFLDRSNMGNAKILNSTRHDDMESSLNMSHRQFDVALMTFVISYAIFEVPSNILLKKLRPSRWLSFLMFGWGAITVSLSGVRSFSAVAGVRFLLGMFEAGLFPGLVYYLTFWYRHDERSVRESKSSNRVDGERAVASVAFVLASATLAGAFGGAIAYAIGHMNGVRGLQGWRWLFIIEGIPSCISAFFVFFLLPDYPEKASWLSKSEKDLAATRLLHEGSSSSQKSMSWADAKETLTDWRLYAHYAIYFAICSPFASLSLFAPSLTANMGFGDLTAQLMTVPPWAVAYVLMFVDIRIVCQIIVAYSADRFNARSVHAAGAAFVGAAGFAALAALPPSAYKARYGALFLAASGTFAGLPPLLGWLTCNLFSTASTGLAVAINVSIGGGLGQVPGIWAYNPSEASIGYPTGHWTNAGLLLLVTVLTLALRAFYGRENKRLTADEAAKGGRGEQVRLYKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEG8</accession>
    <name>A0A367LEG8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutathione hydrolase</fullName>
            <ecNumber evidence="3">2.3.2.2</ecNumber>
            <ecNumber evidence="3">3.4.19.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Gamma-glutamyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Gamma-glutamyltranspeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_0894</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an N-terminal (5-L-glutamyl)-[peptide] + an alpha-amino acid = 5-L-glutamyl amino acid + an N-terminal L-alpha-aminoacyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:23904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9780"/>
            <dbReference type="Rhea" id="RHEA-COMP:9795"/>
            <dbReference type="ChEBI" id="CHEBI:77644"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:78599"/>
            <dbReference type="ChEBI" id="CHEBI:78608"/>
            <dbReference type="EC" id="2.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:59468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="ChEBI" id="CHEBI:143103"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>glutathione + H2O = L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:28807"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sulfur metabolism; glutathione metabolism.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.2" evidence="3"/>
    <dbReference type="EC" id="3.4.19.13" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEG8"/>
    <dbReference type="STRING" id="1330021.A0A367LEG8"/>
    <dbReference type="OrthoDB" id="1081007at2759"/>
    <dbReference type="UniPathway" id="UPA00204"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103068">
        <property type="term" value="F:leukotriene C4 gamma-glutamyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.130:FF:000001">
        <property type="entry name" value="Gamma-glutamyltransferase 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.40:FF:000008">
        <property type="entry name" value="Gamma-glutamyltranspeptidase (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00066">
        <property type="entry name" value="g_glut_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF62">
        <property type="entry name" value="GLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016875351" description="Glutathione hydrolase" evidence="4">
        <location>
            <begin position="19"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="1">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="379"/>
            <end position="381"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="431"/>
            <end position="432"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="454"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU368068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI12806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="551" mass="58948" checksum="9851E65FD126703F" modified="2018-11-07" version="1">MMPLPWAISLFFAAVGASQDGPKLGAVASESAVCSRIGTRLLQSGGSAADAIVGTILCVGTVAMYHSGIGGGGFMTIRAAGGERYETVDFREVAPAAAFEDMFKNNSDASNFGGLASGVPGELRGLQYLHTKYGKLDWSQLVMPSVHLARYGFVVTDDLASRMSSEANSFLTGDPAWAMDFAPRGRRLQKGQVMTRKRYADTLERIAVDGVDAFYSGAIAQATIAALQARNGTMTMADLANYAVVHRKPVHIDYRGVRLTSCNAPSGGIVALSALNILGGYDRFGDSFHLDTHRLDEAIKLAYGQRTKLGDPSFTDVANLTAAMVSPQHGHRLRSQISDLTTRDVSWYDPDRFESHDSRGTSHMVAADATGLAVSLTTTVNALFGSRLMVPETGIVMNNQMNDFSIPGVSNGYGYVPSPSNFIRPGKRPLSSISPVIAETSQGRLLFSIGAAGGSRITTATIQNIIHLLDRRMNMADALGQPRLHDQLLPPHVSFEYPFDNGTVAFMKSLHHNVTWVAPGQSTAQGLRLLPNGTFEAAGEPRQLNSGGFAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEG9</accession>
    <name>A0A367LEG9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_0397</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEG9"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI12824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="98" mass="11422" checksum="15F51B5A4C7567E3" modified="2018-11-07" version="1">MWRLGNQQQQQQHGRWHDQQQPSFASPPISLTRIEMTPSPHHSWNVPFVVGYLEIFFPAPSFLMPFLLFADIGLAFVYKYKTSSMPYRGHAINLHLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEM6</accession>
    <name>A0A367LEM6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_1081</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEM6"/>
    <dbReference type="STRING" id="1330021.A0A367LEM6"/>
    <dbReference type="OrthoDB" id="2162994at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47172:SF24">
        <property type="entry name" value="GATA ZINC FINGER DOMAIN-CONTAINING PROTEIN 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47172">
        <property type="entry name" value="OS01G0976800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GATA-type" evidence="8">
        <location>
            <begin position="354"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="139"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI12871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="406" mass="45167" checksum="13FDC7B9A2BE0B40" modified="2018-11-07" version="1">MATATVLAPSAHYPPPPSYSPPPPSAMMGPDSRTCLNDEPQNRQSLPSISEVISGTRQGQYPPPPPSVINLPSPFCSASQQQQQQQQYSEADKHASPFPPRQDTLSALVDSPRPLPFTSRHSLPTVVADRRATPPIKQDLHAAQKPPDVPHPPPANGSYPHPPAPTSHPYQPGQLPSGQVSLPGYPISPRHAVPCPPSSHFDEAEFANRARYEVPPNRHFETWSYQDSLSRVRSIIPFLGIGSSSRTIYTFAEAYTRIAREQHGSQPIPERLPTEREVNEMLVNVDLIKRSLDQVKDAIQVSIQNERAREGAKVKSSTYDEDHDMAMYGDAMKPQYAMQHEVKKRRGRAAPPGRCHSCNRIDTPEWRRGPDGARTLCNACGLHYAKLERKRQLEARSIRPKAEDRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEQ1</accession>
    <name>A0A367LEQ1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_1349</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEQ1"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI12897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="281" mass="29859" checksum="4B3DF23A29C7DC66" modified="2018-11-07" version="1">MPPFSSSNSPSPTVRFLFLRASHSHPVTGPSCIILTAAQPARCKREKKEASHTFKKLSPQSFVGATMNDASSKNSPPSSSPPRSRLRAAEWIPPLLISPLPDSPAFLSSSSPPLSLLPPAEKAGPGEGFPKENEPSRSYIRILFFFFFFTFSVLLPLVSMQISQRLGAGTPSSTATILERLVIACLQRLQGSVQVSVPPPHLFPARADLDLRFKGKKGIHSFVGRGLAVTDPVAGPTVAKPSKVFPRRLVDWVPDPAGVASTSDGFGAAAQGGCEPAATPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LES2</accession>
    <name>A0A367LES2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_0761</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LES2"/>
    <dbReference type="STRING" id="1330021.A0A367LES2"/>
    <dbReference type="OrthoDB" id="7933078at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd10429">
        <property type="entry name" value="GAAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF50">
        <property type="entry name" value="PROTEIN LIFEGUARD 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI12916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="279" mass="31011" checksum="CB10187A18467942" modified="2018-11-07" version="1">MASSSNAKYQPAPQREPEEEDYTRAPPAYASASAARDEAQGLFGPPRSSEDNLPDDFKFGGSVAEATVDIRNQFIRKVYTILTIQLLATAGLSAVSFFNASYKSWIQHHQALVWISLISSLVFMGLTYWKRKSYPTNLLFLSAFTLAEAYTISVIVSFYKTSVVLNAVVLTAGIFIFLTAFACQTKYDFTSWMPYLFGAIWGLFLFGLIAVFLPYNSTVELVYGGVAALIFSAYILVDTQLVIRKHHVEEEIAAAISLYLDIINLFLAILRILNGQSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LF24</accession>
    <name>A0A367LF24_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_1096</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LF24"/>
    <dbReference type="STRING" id="1330021.A0A367LF24"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="60"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="604"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="197"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="604"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI13017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="731" mass="79623" checksum="9473CFCDC39A3391" modified="2018-11-07" version="1">MLGSLHADDSAAPADTGHGGAGEHPIATGQKRQAASSTTMQGPGSEPPRRPKRGKYTPVACDECKKRKLKCIPAGDAGCERCIAGGLACAYASGPPQASRRGNHSDQVRVLGEEMAQLRQQVADLVGTVQQLRHVEPCVRSGSRQSCDATVVPSPSAAAGAKDGVPKQPQFVGPTRPTFGLIVGERSLTRMGIPTFESPPPSAAPSPSEPPRDATSELDFWLRCTPDEVARLLSVFEEEVESVYPFIDIAELASRASHTLELLRSPAPSDAESPKDVEITKIAVATALVVEAHGKSELSTTLAESVERHVSRIASPQVDLQEIQLLTMLSIYYFHCDDELLAWRTIGIAAREALEMGLHRKKSLFDNFNDPDARRLATRVFWCVYVLDRRWSFGTSLSFALADRDIDPGLPEPLWDAIPPLGSPTLSIPEETIHALDISTQDWLESIPPHLRLRHPRLGLAARSQPRVLQRLRALLYLRGNHTRLSIYQHCLFSTPSINSNLNSAWLVINIAQDSLQVLVHLNDTTDIYSRQQNAFNYFLLSALAVIFLAVCHAPNIFAEPCRKSFLDAIDLVRGFSSHSVVSRRLWRTIRGLLPRLRSLGLQGSDDGAPTTTTRESPTGTATATASASVAAPSGEGRGMSEFRDNNLQDPPSAPSVWDAQTSSDMVADADMSGSVPDMFQMRNDLLDLFDALGQGQQFPGEFGNHFYGPDDTDLLNGRGGEITRRLQGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFI7</accession>
    <name>A0A367LFI7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_0367</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFI7"/>
    <dbReference type="STRING" id="1330021.A0A367LFI7"/>
    <dbReference type="OrthoDB" id="6339427at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005366">
        <property type="term" value="F:myo-inositol:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904679">
        <property type="term" value="P:myo-inositol import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000073">
        <property type="entry name" value="MFS myo-inositol transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF12">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="144"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="290"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="434"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="1"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI13194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="476" mass="50988" checksum="00A4172F972A7FE8" modified="2018-11-07" version="1">MDSPRAPLMVDHDDDVEPSDLRPAKPTNVDDTGVISATLVSIGDSLSHRPLTTMDKSIITSSTSLFALIASPLSSMLADKVGRKRVILYADILFVAGALVQALCSTVPLMVMGRCIVGGGVGAASFVVPLYIAEVAPASHRGKLVTTNVLFITLGQMVAYVVGWLLSTYVTRDTGWRWMVGLGAAPAVLQAAVIVFMPETPRWLVKVGRSEDARTVMRRVEPASTGDLVADMEAEVREEREVSRMRGHSGVWRELLGEARNRRALTVACLLQGLQQLCGFNSLMYYSATIFSLVGFASPTLTALTVAVTNFFMTLAALSLIDRVGRRRILLWSMPGMMMGLVAAAAGFSKLSPEVTTVSGRGGPARVILASIMVYVATYALGLGNVPWMQSELFPLAVRSVGSGVATATNWSANLAVGLTFLPMMEALSPAWTMGTYAVVCFVGYVLVWRIYPETAGLSLEEAAAGARMGRRQIEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFQ5</accession>
    <name>A0A367LFQ5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7624 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_0342</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFQ5"/>
    <dbReference type="STRING" id="1330021.A0A367LFQ5"/>
    <dbReference type="OrthoDB" id="5230484at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056041">
        <property type="entry name" value="DUF7624"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24616">
        <property type="entry name" value="DUF7624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7624" evidence="2">
        <location>
            <begin position="534"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="707"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="500"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI13248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="729" mass="80322" checksum="590FA0A7FFBE7343" modified="2018-11-07" version="1">MALEAPLSCPANILPYSENPICLTLTASDPRCGQCLFHPSQFLAVIRFPETPLAHRASASAMSLLSPSDIVGPSPVTSNGTETTEIEDDVAEDVQHAHMTDVAALRGSGLPVLATNLPDAVRQPSSEDAVSVIHAPESLSSWSPPSLSRPPISTDVKPVRYSIDSATPRAQDLQDMLNDSARLRSSSSSSLEKIDEQAEAEVDDEDDMDDDAYRQRPLTSSETDGIASLRAALHECWTLTNTLANLSSKHRNQVFNNSETPDAHEKAWKTCWKLCKHLYHDQGGDNESQNVTTNLHLCRDFCQALFDVRQRRDETADSVLRVSFELNNHVQNSMKLPEAFRARTLDFYITLCHRLMKQRSELAKETNELLRACWGLAEMLFSMRQRRRDGRSADEGLLGSAVLACWELCDIFRDGWTQIRPDRDTPRPSQTAFFMDQAGVESRRSSRSSVYSKRDSVKSLQEERPRKPPPVPETPITEFEDTPVSPESRSPQLPNIMVLGTTTSEGGRGGRWSSNASNMSSYSRSSNRTSSTAKTTAVGDFNMARAKILVVRAAMDLGFDRDSRGADGKEANGASLQNFVQGLRAATLGSSAAAAVTSTSSSSSSSPSMPSQATLLQQYQKSIVVDALIPRGQALPSRGERVSAQDMAKSVQALGSSSPRLAYLRDLFLLVFQFPIEEAESRRNVLITLPFLVLTLNQQKKMIKTQSVYDYDKKKPPNTRNPYSPTPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LG04</accession>
    <name>A0A367LG04_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_0868</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LG04"/>
    <dbReference type="STRING" id="1330021.A0A367LG04"/>
    <dbReference type="OrthoDB" id="2444812at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="71"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI13364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="287" mass="30660" checksum="3C0A7B1CEF72D20C" modified="2018-11-07" version="1">MSFLKNFTKDFDRFGIGDKKQDQQQQQPPPPPQGYGRYESQDHYPAASSAAAQYNASPPPLPAYQPPPDKPPLPTGWTPLFDQQRQRWYYVDEASGHSQWEAPGYVAAPPSPTAAGYAPPVGPPPGYGQQYGPPDGPPPPSSHAGYGPPDGPPPAARYDGGYAPDEGGEKKHGGKGGILLGAAGGLAAGAAGGALLHRMSSRHDEDEYHQQTPSTESYGQAAYGHEPYQGRDDNNRESSSSSSTEDDRRGRREESSSSSSSEDDGHGGADYDDDDDDRYDSGSDDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGR5</accession>
    <name>A0A367LGR5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGR5"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI13601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="77" mass="8220" checksum="938CB6CC5BB4F981" modified="2018-11-07" version="1" fragment="single">MLIRRLIILLKKARLACLILKRPPPTLLCRSYLSSVTYGGLGPAAAGPASRDPPRPSGRVPCVCVRVSSAPAKLARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGZ7</accession>
    <name>A0A367LGZ7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SRP9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_7953</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SWD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGZ7"/>
    <dbReference type="STRING" id="1330021.A0A367LGZ7"/>
    <dbReference type="OrthoDB" id="27537at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039432">
        <property type="entry name" value="SRP9_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037867">
        <property type="entry name" value="Swd2/WDR82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861">
        <property type="entry name" value="WD40 REPEAT PROTEIN SWD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05486">
        <property type="entry name" value="SRP9-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="58"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="137"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="SRP9" evidence="8">
        <location>
            <begin position="418"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="439"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="517"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="539"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI13714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="561" mass="61585" checksum="1C667ECAA301FC49" modified="2018-11-07" version="1">MPSTPMDVDRTGPSLNIHRTLPGANTSALNLSDVISSYRPTKLLKREDIKDGQAQPRVLSVDYDDEGELLMTSASDETIQIYNVREGRHDKSLLSKKYGVKLAKFTHTSSSIVYASTKQNHAIRYLATHDNSFIRYFEGHEADVTCLGVHPGTDNIISCSKDNTVRLWDTQTKHWQGQLMLKNPALAAYDPSGTVFAVACPSSGSILLYDIRNYEKAPFATFDVVEQCGSIDPQIIMRGWTKLEFSNDGKSLLLGTRGGGHLLFDSFDGTFKAYLRKPAAGTRRQAPGEAVAVVNGNTVTDPSCLESSGDCCFTPDGRFVLSGTKQDVLVWDTLSLASQGLILDPTWTLPDKREAAVVAFNPRFNFFATADQDLEWLDASSLLIEARPSTTKNPPPFSLYNGFSNPIQLTKVVATYQKHSQTRITTRFSIKTVKPFVTKKQKAPGSPTDAEIAQPSTRPPRGSLVLKTYDPVSGVTLKYSTYQAAEVSRLFHISLGRLARAMAALPAVAVADEPMLDQPLPSADAPTKIREVKAATSKQQQQQQQQQQTGGVGHRKKKGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LH09</accession>
    <name>A0A367LH09_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7954</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LH09"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI13708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="131" mass="15116" checksum="5944620CF768DCA5" modified="2018-11-07" version="1">MLLDSVSRPRRAVRACRRRRYQLPGNGTTTTYFMTDIPHLTGEGTLCLLALQFVEAEHEHHHLVNKHLIVALKNKLRCEPKLLSDFDRGFRDGYTWGTWWTKYCIYRSLLGGYLPRCGATSKVPSLYLSTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LH17</accession>
    <name>A0A367LH17_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_7958</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10 11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10 11">Cytoplasmic vesicle</location>
            <location evidence="10 11">COPI-coated vesicle membrane</location>
            <topology evidence="10 11">Peripheral membrane protein</topology>
            <orientation evidence="10 11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10 11">Golgi apparatus membrane</location>
            <topology evidence="10 11">Peripheral membrane protein</topology>
            <orientation evidence="10 11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LH17"/>
    <dbReference type="STRING" id="1330021.A0A367LH17"/>
    <dbReference type="OrthoDB" id="10266042at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051645">
        <property type="term" value="P:Golgi localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09254">
        <property type="entry name" value="AP_delta-COPI_MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14830">
        <property type="entry name" value="Delta_COP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000003">
        <property type="entry name" value="Coatomer subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027059">
        <property type="entry name" value="Coatomer_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121:SF0">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="13">
        <location>
            <begin position="296"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="179"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI13715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="533" mass="58728" checksum="BFF6388827E651A4" modified="2018-11-07" version="1" fragment="single">GLPKEPSVIQQSHLEQKPSQSVVEMVVLAASICTRGGKAVLSRQFREMPRSRIEALLASFPKLADSGTQHTTVEQDNVRFVYQPLDELYMVLITNRQSNILQDIDSLHLFAQVVTSACKTLDEREILKNAYELLSAFDELVTLGYRENLTMSQIKAFLDMESHEERIQEIIARNKELEATEERKRKAKQLEMQRKESARSGRGGMSRTPAYPTYQAPTRPNAPDAYDTYEAEKNRTYNKSTPKGKGMQLGKKSKTTDMLERIRGDMGGEADNAPLITPTSAAAEPAEPRVSSTLDRDAIHIVISEAISAQLSRDGAINSLAISGDLTLRVSDPALTKIKLSLQAVPSHGAQFRTHPNVDRGLFNSSKVIQMSNAARGFPVNNAVGVLRWRASPKVDDNSACPIIFTVWTNKESAKCNVTVEYELTGGDALKEVSVAIPYAGSEPVVSSFDAAYEVSGDAVEWSIGSVDSENPSGSFEFESEGDENDFFPMTVRFSKTTPYIDVDVASVSLLEENEAVTFSKEIKSHADNFSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LH26</accession>
    <name>A0A367LH26_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_8112</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPRTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LH26"/>
    <dbReference type="STRING" id="1330021.A0A367LH26"/>
    <dbReference type="OrthoDB" id="106623at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008655">
        <property type="term" value="P:pyrimidine-containing compound salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000023">
        <property type="entry name" value="Probable uracil phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001097">
        <property type="entry name" value="PRK00129.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="10">
        <location>
            <begin position="24"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI13744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="230" mass="25907" checksum="86D7807D83BA4BBE" modified="2018-11-07" version="1">MENNDELSATLSAVVPFDNVHVLPQTPQLIALLSIIRNKDTERADFIFYSNRIIRLLVEEGLNHLPVIQRDITTPVGRTYNGLMFQGKICGVSIMRAGEAMEQGLRDCCRSVRIGKILIQRDEETSQPKLFYDKLPQDISHRWVLLLDPMFATGGSAIMAVQVLKARGVPEDHILFLNLIASPQGVSNFAKKFPRLKVVTAFIDQGLDEKKYVDYIIPGLGDFGDRFYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LH69</accession>
    <name>A0A367LH69_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_8232</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LH69"/>
    <dbReference type="STRING" id="1330021.A0A367LH69"/>
    <dbReference type="OrthoDB" id="1697570at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000021">
        <property type="entry name" value="40S ribosomal protein S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_uS4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005710">
        <property type="entry name" value="Ribosomal_uS4_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003139">
        <property type="entry name" value="PRK04051.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01018">
        <property type="entry name" value="uS4_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF5">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="10">
        <location>
            <begin position="96"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding S4" evidence="9">
        <location>
            <begin position="217"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="273"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="294"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI13768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="303" mass="33850" checksum="3C6E9FE627FA0BB7" modified="2018-11-07" version="1">MSPTLRKVSRTSPSSCHMYHIPIRSQSSTYAGSRSLSVRVAHRVSVAGQSFVVGEVRSVGDDGSSLAFLANFSASRRNSSTSATKTGSPGCLLAPTPRHPVLRADPSRLPDCQYHRPLNQRRASVQVDYAGDNSDSELKLVGEYGLRNKREVWRVGLTLSKIRRAARQLLTLDEKDPKRLFEGNALIRRLVRVGVLDESRMKLDYVLALKIEDFLERRLQTCVYKLGLAKSIHHARVLIRQRHIRVGKQIVNVPSFIVRLDSQKHIDFSLKSPFGSGRAGRVKRKKAKAAEAAAEGEEEEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHC0</accession>
    <name>A0A367LHC0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar complex-associated protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_8007</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for synthesis of 60S ribosomal subunits and the transport of pre-ribosomes from the nucleoplasm to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHC0"/>
    <dbReference type="STRING" id="1330021.A0A367LHC0"/>
    <dbReference type="OrthoDB" id="10263597at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011501">
        <property type="entry name" value="Noc3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016903">
        <property type="entry name" value="Nucleolar_cplx-assoc_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428:SF5">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07540">
        <property type="entry name" value="NOC3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028977">
        <property type="entry name" value="Nucleolar_complex_p3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Nucleolar complex-associated protein 3 N-terminal" evidence="8">
        <location>
            <begin position="126"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="CCAAT-binding factor" evidence="7">
        <location>
            <begin position="480"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="530"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="350"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="454"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="530"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR028977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI13810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="662" mass="74263" checksum="9D08A947F04A1A42" modified="2018-11-07" version="1">MPSGENKRRKLIHCSSDDDQDHTTTSKRAQKDFFVNASNWNLEQDYALRKRKDKKNKNKESSFLPQINTSKERPEHLPSRFADDDVVSVVSDTEWLEGREDEIEAEPDVEEKEAEIEIPEAQQVLQAQEELAKMALTINENPEENVGSLKAMAKIGQSRLSSIRMLTLLTQMAVYKDIIPGYRIRPHAETAPAQKEKVSKEVRRLQQFEQSLIHGYQAYVRQLADCAKSEIQRLSSTALTCACELIRAVPHFNFRSDLLKILVGKLSRRTTALDAADALKCREALEHMFREDEEGRPSFEAVSLLTKMMKARNFNIDEAVLNLFLSLRLLSEFSGKASQDAVDFPGNAGPKKKTKREFRTKRERKALKEQKALDKDMAQADALVSHEERDKMQSETLKLVFATYFRILKLRLPRLMGAVLEGLAKYARLINQDFFGDLLEALKDLIRHSDDDVDADAAQGDDADDQGNDPPSNRNLTREALLCTVTAFALLAGQDAHNARRDLHLDLSFFTLHLFQTVLSLSTDASLEDTTASPLSSSSSSSSSSTTSPTFKVNVQTTTVPPLRLAAFTKQLMTASLHLPDRSAQAVVALVADVVATHSTKVSALWNSDERRGDGLFNPHSDSVEGSNPFASTVWEGELLRLHFSPKVRDGIKRLEKSLPQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIP9</accession>
    <name>A0A367LIP9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_6134</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIP9"/>
    <dbReference type="STRING" id="1330021.A0A367LIP9"/>
    <dbReference type="OrthoDB" id="4927600at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017000143" evidence="2">
        <location>
            <begin position="18"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI14280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="265" mass="27516" checksum="4228489B6307FB36" modified="2018-11-07" version="1">MKLYMAVLGILASTTSAVTPIRRLHFPRNNGTSYGGDVAYAAPKPALVTGYDNDDETVTATMTSVLHKTRTSYVHSSSSATPPVDSAVKATIPESKDGKEDNNNNNNKADDDDDSSSSSSSSSSSSSSSSSPSLSTTTVTSKTLTTVTISRGASNSAAADTKDGEKGQGQDRCSASTVTVTQPPVTKTVFVTATPGANERVPVFDKYRVSSFHKDPSSAGITSSDVPATTVQSVVTVMPFPTGRNGTYVPGAARPSTLARLYRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJB3</accession>
    <name>A0A367LJB3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_6850</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJB3"/>
    <dbReference type="STRING" id="1330021.A0A367LJB3"/>
    <dbReference type="OrthoDB" id="410307at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000035">
        <property type="entry name" value="CCCH zinc finger protein, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46156">
        <property type="entry name" value="CCCH ZINGC FINGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46156:SF1">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="301"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="330"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="357"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="301"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="330"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="357"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="413"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="422"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI14515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="466" mass="51340" checksum="8884503307EE085A" modified="2018-11-07" version="1">MSDEDKELLARIGQLAGQINRHKSQQATVAPGTQPAPQRLNAYRHSSAPYPRAGYRGGRPALAHRHRTLRLNDPKTRQESDAADGEVSSGGQGKWVSRTDRHRQLINADIYQKDAQNRFKAMEESRQRKIRHQRSREKRRFNDYLRRQTATAASVAESVNEIIIDGMRFRVADGGKKLLKVADDLQSAPSTPKTVDVAGVTFHRTKTGNLVASRVVRDHRYVFRPVDGVKLTAGSRSGVVKKTDQMCRIFSTTGKYLIRRSGPGRLATKRPPFLSPPSPSPPLQPIGSCPKGPRCRYIHDANKVAICREFLKEGKCGDGDSCDLSHEVSPERVPNCVHYAKGHCAKPDCPYTHSKAAPGAAVCEAFGFLGYCEKGSECRDRHVSECPDFSNTGSCKTKGCKLLHREKASVLRAHGKARGEASDDDVSSDEDSACSDDVDSDEVADFVQAETDESDADADGQDFIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LL43</accession>
    <name>A0A367LL43_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LL43"/>
    <dbReference type="STRING" id="1330021.A0A367LL43"/>
    <dbReference type="OrthoDB" id="5369511at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="347" mass="38669" checksum="285B00BAF7B5F719" modified="2018-11-07" version="1">MISEDMAQPAHACQTPAISQDPWIAARSSFAEPYGNAGFSGGLFLPSSISYPTGAFPPTGFAPSALSNGLHGNRVLPTAAAGTTPGYAARPPPAVNTAVGSSYGSFQSLQSSWEAQDRYSPTGSLDEIMASPNLSDYSAENGINNANPRAQAKAKAKRATQRRPSNRDEFDGPHQFLQRPPPEVIAMQERELPHLPTNLHVQEQDNVLNQVNDRLSQCAYDFVAKYQFPIPLTQDMRPVERPQDREWTEWVYLLKRLATKRRIPARVLYNGQIKQFVTILENSLEMRHAAKHQSRPLKDDRNILQLISAGIQVAKILKDASAMEYLDRLYVNTDKRIQERTASRFRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LL47</accession>
    <name>A0A367LL47_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_6552</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LL47"/>
    <dbReference type="STRING" id="1330021.A0A367LL47"/>
    <dbReference type="OrthoDB" id="46529at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000033">
        <property type="entry name" value="acyl-coenzyme A thioesterase 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003736">
        <property type="entry name" value="PAAI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00369">
        <property type="entry name" value="unchar_dom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF11">
        <property type="entry name" value="FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04355)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="3">
        <location>
            <begin position="53"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI15131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="154" mass="16547" checksum="4A7A30C2B93DE4D7" modified="2018-11-07" version="1">MESRTQHVKALLQRLLANSPIYGFTLSTLEVVSVTRGVATTRLRLTERHVNSMGGLHGAVSATIVDLTTGLAIASWDCRQTTGASVDMHLSYLSSARVGDVLRIETTAERVGGTLAFVTVRIVKEGEGDKGDEVVTLAQHTKYVKGTEPAVVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLF4</accession>
    <name>A0A367LLF4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_6461</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLF4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016917099" evidence="2">
        <location>
            <begin position="18"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI15241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="216" mass="24408" checksum="8794CDBFE7275E87" modified="2018-11-07" version="1">MKSTLVLIMLATATSLAAKPKGDDPNHHNTSSTEPFPYSQAQQDQRQPHLHKRQGNQFMRHKFKPYCHQDTEACQGTEIWCHEHTPKGMTPEQCIAQRKPLPFSEGDTSGKGNCFSLFPSVDPKLPSQHGLQQAVDKYLRKHKTDEALERCFGTEVWCRLHKDEQRCRKSEEAFPCAGSSSPEKNHPQQNIGQQDDFGPPSQNSINNTSFSHTVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLL1</accession>
    <name>A0A367LLL1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_6380</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLL1"/>
    <dbReference type="STRING" id="1330021.A0A367LLL1"/>
    <dbReference type="OrthoDB" id="9626941at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097525">
        <property type="term" value="C:spliceosomal snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000014">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="4">
        <location>
            <begin position="5"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="60"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI15325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="100" mass="10767" checksum="ADCECC7B456C3CD7" modified="2018-11-07" version="1">MARTILHGTIASVSPQMNTSMRNVKMTAKGQSPISLDTMNIRGSTIRYIILPDSLPLDTLLIDDAPKPKNKARKEAERGGRGRGRGGGRGRGRGRGRGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLN1</accession>
    <name>A0A367LLN1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cullin family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_6389</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAH family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLN1"/>
    <dbReference type="STRING" id="1330021.A0A367LLN1"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000001">
        <property type="entry name" value="Cullin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000002">
        <property type="entry name" value="cullin-3 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000003">
        <property type="entry name" value="Fumarylacetoacetate hydrolase domain-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000061">
        <property type="entry name" value="Related to cullulin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000036">
        <property type="entry name" value="SCF ubiquitin ligase subunit CulC, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.130:FF:000011">
        <property type="entry name" value="SCF ubiquitin ligase subunit CulC, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Cullin family profile" evidence="8">
        <location>
            <begin position="453"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI15319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1075" mass="120653" checksum="EC8D5D5145977942" modified="2018-11-07" version="1">MISGRGSSGARGGRIRPPRRFVRSNGEGTDFEDCWHMLEEALRDIHNKCCGRLSFEELYRAAYNIVLIKKGAVLYQRVTEFEEKWFTKNVIPKIEALVTKNLINIGVDKSSCSVNERRRTGEKFLLGVRDTWQDHNISMNMTADILMYMDRGYTQLETNGVPIFATTIALFRDHILRSCLNGNSPQLVIDLVISIMLDQIDMEREGDVIDRNLVRSCSRMLSCLYEAEEENELKTLYLTVFQPRFLLSSQNFYNRECLRLLRNADVSTWLRHTQRRLAEEVDRCETTVEPETLVPVLEVIDGTLIEPHLNEFISMEGSGLKWMIDNDKMADLSILYTLISRIDANKTALRDTLQKRVIELGIEIEQAFKSTDLTGQGEADEAGGGVGEGADKANKTLLNHAAQQTTSAVKWVDDVLRLKDKFDKLLSDCFQNDLVIQTALTKSFTDFIRLFARSSEYVSLYIDDSLKRGIRGKTEAEVDEMLDKAIVLIRYLQDRDMFQTYYQRHLARRLLHGKSESHDVEKQVISRMKQELGQQFTSKFEGMFRDLVTSSELTSSYRIRMAAVGGGGGGDDDGSRTMDLNINVLTTNYWPQEVMGRQATTSDRSRASCNFPHDVRRLQASFEQFYLASRNGRKLTWIASTGSADMRCTFPAVAGKSGPLARERRYELNVPTFAMAVLLLFNDVDEGESLSFEDIQAKTAISTSDLMRTLTAVAVAPKSRVLIKEPANKSVKQGDRFYFNASFQSKAVRIKAPIISAVSKVEDTQERKTTQDKTDQSRAHTVDAAIVRIMKSRKQLSHTQLVNEVIGQLAGRFKPEVALIKKRIEDLIGHESAMAILKRAILEAKTLALKRAGKVVCIGRNYADHISELRNATPKQPFFFLKPPSSMLLPGQGPCVRPRGVEMHFEVELGLVMGRKVQDLAADDVGRALEAIRAYVVAIDMTARNVQDEAKKKGLPWSIAKGFDTFLPLSRVVDKESIPDPQAVELFLSVNGESRQRGSTALMLHPIPRILSDISRVMTLEEGDVVLTGTPAGVGPVEPGDVMRAGVVVEGREVEDGAIEVAVEESTSSFVFKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LM36</accession>
    <name>A0A367LM36_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_3412</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LM36"/>
    <dbReference type="STRING" id="1330021.A0A367LM36"/>
    <dbReference type="OrthoDB" id="288203at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008271">
        <property type="term" value="F:secondary active sulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.24:FF:000024">
        <property type="entry name" value="Sulfate permease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018045">
        <property type="entry name" value="S04_transporter_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013536">
        <property type="entry name" value="WLM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00815">
        <property type="entry name" value="sulP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08325">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01130">
        <property type="entry name" value="SLC26A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51397">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="465"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="488"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="7">
        <location>
            <begin position="571"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="WLM" evidence="8">
        <location>
            <begin position="837"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="997"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1073"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1148"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1000"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1073"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1087"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1156"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1170"/>
            <end position="1184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI15469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1264" mass="138421" checksum="DFCD673422FA7E50" modified="2018-11-07" version="1">MPGFATRLGPALAKALGIKLQDATGLQPAQRLNSSKAGDDDWFDSGATSSEWLRHQLPSVDGARRYVRSLFPFLSWAPHYNLQWLAGDVVSGLTIGAIVVPQGMAYASLAKLEPQFGLYSSFVGVVSYWIFGTSKDISIGNVAVLSSIVGSVVEDITSLPDAKDMPPHVIASALSVVAGSVVLAIGLLRCGWIVDLISIPSLSAFMTGSAITIIASQLPALIGVSGFSNRDSPYLVVINTVKHLPDVKADAAMGLTALFALYLIRFCLARAAMSFPSKKRIFFFMSTMRTVVIIVLYTFISWLVNMHRREAPAFRVLGDVPKGFRHAGIPQIPSGIISHLASHLPVTVIVMLAEHVAISKSFGRINNYTIDPSQEMVAIGFTNLLGPFLGAYPTTGSFSRTAVNSAAGVRTPAGGLVSGLLVLVATYFLTGVFHYIPNAALSAVIIHAVGDLITPPNSVYQFWRVSPLEVVIFLVSVLVTVFRSIEDGLYVTVCSSLIVLLYRILKERGRFLGRVRVHSVVGDHVVGDDRKLAGNGDIFDDSVLATERDVFLPLHHEDGSNPELEIESPYPGIFIFRFSGMNYSNASSTLDHMSSIILRNTRRSSPVAFKRPGDRPWNHAGSREQSEDDYRPTLQAIILDLSSVNSVDVTSIQCLVDVRKQLDQHASPDVVDWHIACISSRWTKRALASAGFGVPTDRTGRRWQPMYSVAQIGYATERQPNKTQTRVQDVEMGTDNSDGTEIHSSSSLETAVADEKGAIVVSRPRYAEAAVYGRDKPLFHVDLTSALQSAIANVEARREFRPGETVGGGWQTLSLRPESGSPTDALAMPWGFERVNSKTSQPNANIVFIKPLKGPDEKTAQEFLERIAAQCVPIMRKHHLYVMALEEFEPNREFVGRNFNAGEVIQLVLKSRSSGRWLPFEYVQMVMMHELAHCKQMNHSRAFWTVRNGYAEEMRRLWNQGYTGDGIWGRGTKLATGAWEKDMVRSDEILPEHLCGGTFRTRRGKSTKKRPAPSYREREDRRIRRKFGENGTVLGADEEVKTKLERGKRVQAKPRVANSERGRQLRAAAALARFDKGKEESAKTEDTEGVSESGDEGLQDAAAVDGEGNPLLDCQGRELVKVCEDEDVNDVDARGELDELRHVFRKGRVKEEEEEEKKKVVGEAKVKQENEEEEGDDVDDDEPPVTEGIGKHAGEPSKPVGTRSCSACSFINMGLGTTCAMCANVLEPERTAGTWRCGSGRCASYANSADSGVCGLCGGTGRVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMD4</accession>
    <name>A0A367LMD4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sm protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_3395</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the snRNP SmB/SmN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMD4"/>
    <dbReference type="STRING" id="1330021.A0A367LMD4"/>
    <dbReference type="OrthoDB" id="2020720at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:cytoplasm"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
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        <property type="term" value="C:U2-type prespliceosome"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:U4 snRNP"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="Sm_B"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Small nuclear ribonucleoprotein SmB, putative"/>
        <property type="match status" value="1"/>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
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        <property type="entry name" value="snRNP_SmB/NAA38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="88"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="163"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="206"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
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    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI15547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="231" mass="23644" checksum="072227B9B6411E1F" modified="2018-11-07" version="1">MSNKQGKMINWRMRVILNDGRQMTGQMCAFDKHMNLVLADTEEFRRVRRRQTRTPAPGAEPVTQVVETEEKRTLGLIIVRGAHVVSVSAESPPPADPSARLGRNVAGGITSTLSAGPGVAKPAGRGAPPSSLAVSSRSSSRSRTSSADSEQGPAAGVGSGAPPGFPAFPGQPPFGRGGPPPGYPGVWPPPGFPANFTGPSSFTNPGIPPGGPPGAPGAPGPAPGFNPPPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMF4</accession>
    <name>A0A367LMF4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Carbamoyl phosphate synthase arginine-specific large chain, mitochondrial</fullName>
            <ecNumber evidence="14">6.3.4.16</ecNumber>
            <ecNumber evidence="5">6.3.5.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Ammonium-dependent carbamoyl phosphate synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Arginine-specific carbamoyl phosphate synthetase, ammonia chain</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Glutamine-dependent carbamoyl phosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">L249_3355</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>hydrogencarbonate + L-glutamine + 2 ATP + H2O = carbamoyl phosphate + L-glutamate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>hydrogencarbonate + NH4(+) + 2 ATP = carbamoyl phosphate + 2 ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:18029"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58228"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-arginine biosynthesis; carbamoyl phosphate from bicarbonate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Heterodimer composed of 2 chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CarB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.16" evidence="14"/>
    <dbReference type="EC" id="6.3.5.5" evidence="5"/>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMF4"/>
    <dbReference type="STRING" id="1330021.A0A367LMF4"/>
    <dbReference type="OrthoDB" id="1924069at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004087">
        <property type="term" value="F:carbamoyl-phosphate synthase (ammonia) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004088">
        <property type="term" value="F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01423">
        <property type="entry name" value="MGS_CPS_I_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000004">
        <property type="entry name" value="Carbamoyl-phosphate synthase (glutamine-hydrolyzing)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1380:FF:000015">
        <property type="entry name" value="Carbamoyl-phosphate synthase arginine-specific large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1030.10:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000001">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000002">
        <property type="entry name" value="Carbamoyl-phosphate synthase large chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1030.10">
        <property type="entry name" value="Carbamoyl-phosphate synthetase, large subunit oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1380">
        <property type="entry name" value="Methylglyoxal synthase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036897">
        <property type="entry name" value="CarbamoylP_synth_lsu_oligo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005483">
        <property type="entry name" value="CPSase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005480">
        <property type="entry name" value="CPSase_lsu_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058047">
        <property type="entry name" value="CPSase_preATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011607">
        <property type="entry name" value="MGS-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036914">
        <property type="entry name" value="MGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003671">
        <property type="entry name" value="PRK05294.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405:SF53">
        <property type="entry name" value="CARBAMOYL-PHOSPHATE SYNTHASE [AMMONIA], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11405">
        <property type="entry name" value="CARBAMOYLTRANSFERASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25596">
        <property type="entry name" value="CPSase_L_D1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02787">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00098">
        <property type="entry name" value="CPSASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01096">
        <property type="entry name" value="CPSase_L_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48108">
        <property type="entry name" value="Carbamoyl phosphate synthetase, large subunit connection domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52335">
        <property type="entry name" value="Methylglyoxal synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51855">
        <property type="entry name" value="MGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ATP-grasp" evidence="22">
        <location>
            <begin position="229"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="22">
        <location>
            <begin position="816"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="domain" description="MGS-like" evidence="23">
        <location>
            <begin position="1082"/>
            <end position="1231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00047359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00068891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="RCI15625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1231" mass="135164" checksum="44B7E5A1615226BA" modified="2018-11-07" version="1">MTLHPAVRGTVQSTSSPGASTMLPYALAGRAPAVVVRARGGSSRALMRAYQSATKTTTLLRLSHRLPRPRLYTSAANAAAAAAPNPQAYLKSGIIKPKQVVDVKKVLVIGSGGLAIGQAGEFDYSGSQALKALKEAGVASVLINPNIATIQTNHELADEVYYLPVTPEYVSYVIEREKPDGVFLSFGGQTALNLGVQMQRLGLFEKYGVKVLGTSVRTLELSEDRDLFAKALEEINIPIAKSIAVGTVDEALDAAEKVGYPIIVRAAYALGGLGSGFANNKEELRNMAARSLTLSPQILVEKSLKGWKELEYEVVRDANNNCITVCNMENFDPLGIHTGDSIVVAPSQTLSDEEYHMLRSAAIKIVRHLGVVGECNVQYALQPDGLDYRVIEVNARLSRSSALASKATGYPLAYTAAKIGLGHSLPELPNAVTKTTTANFEPSLDYIVTKIPRWDLSKFQHVKRDIGSAMKSVGEVMAIGRTFEESFQKAIRQVDPRFVGFQGDKFDDLDRELQNPSDRRWLAVGQAMLHENYSVDRVHDLTKIDKWFLYKLQNIVDCTRELEDAGGLQALTKSQVLKAKKMGFSDRQIAMAVKSTEDDVRKYRLRLNIHPWVKKIDTLAAEFPADTNYLYTTYNGSTHDVTFEDKGTAVLGSGVYRIGSSVEFDWCAVSAALALRQMGHKTIMINEYNPENVSTDFDTADKLGVYRIGSSVEFDWCAVSAALALRQMGHKTIMINYNPENVSTDFDTADKLYFEELSYERVMDIYELENSSGVVVSVGGQLPQNIALRLQESGGAKVLGTDPKDIDKAEDRQKFSEMLDSIGIDQPAWKELTSVKAAEDFAEQVGYPVLVRPSYVLSGAAMTVIRSKEDLKDKLEAASNVSPDHPVVISKFIEGAQEIDVDGVASKGELVIHAVSEHVEQAGVHSGDATLVLPPVNLDEATMGRLKGIAQKVARAWNITGPFNMQIIKADNPEGHGEPLLKVIECNLRASRSFPFVSKVLGCNFIDVATKALVGKDVPKPTDLMAVKRDYLATKVPQFSWTRLAGADPFLGVEMSSTGEIACFGKDLVEAYWASLQSTMNFRMPEPGEGLLFGGDVSKKWLTQVIDYVAPLGYKLYAASQDVKRFIESTSRDKVAVEVIEFPTDDKRALREVFKKHDIRGVFNLAVARGKTTQDVDYVMRRNAVDFGVPLFMEPQTAILFAQCMSEKLPRKEGIPSEVRRWSEFIGGKPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMS7</accession>
    <name>A0A367LMS7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMS7"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="144" mass="16277" checksum="4F98F2FAC748EBA8" modified="2018-11-07" version="1">MTLPCLQDLTQYLHRCPTHQIKKNKTTSTTETSYTNIIYIRSTYIPMYSMSSRSCPIDDPFIALSRLYSGQIVPLLKRTLRKQPSSRTRQSVYMVMVVVVVVVVVTMTFGISTNLGMPRTTLRYALGSSPAAKAMRNMSAMKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LN60</accession>
    <name>A0A367LN60_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_1935</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LN60"/>
    <dbReference type="OrthoDB" id="4907689at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI15874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="137" mass="14971" checksum="4EC9971BBF7E18A3" modified="2018-11-07" version="1">MSDATDRSAAAAAAAVHGASWSSCLLRSSLLPPIAAFLNRCTLGRALFPRNVKIRSGYHEVTACAWAGFRRPFLRRSNLQDDLKFIKLLGYGVDGVVWQVEIGDRVVALNQALQRESQDASILQMVQLAVEHYGASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNH7</accession>
    <name>A0A367LNH7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Aspartyl aminopeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_2034</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the peptidase M18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNH7"/>
    <dbReference type="STRING" id="1330021.A0A367LNH7"/>
    <dbReference type="OrthoDB" id="9880441at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05658">
        <property type="entry name" value="M18_DAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.250.10:FF:000001">
        <property type="entry name" value="Aspartyl aminopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="entry name" value="Aminopeptidase i, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570:SF4">
        <property type="entry name" value="VACUOLAR AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101821">
        <property type="entry name" value="Aminopeptidase/glucanase lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 9" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="250"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="397"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="263"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="397"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI15927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="568" mass="61720" checksum="67B247547E793A9B" modified="2018-11-07" version="1">MRTSPSRIVLAITFSPQKRTFVTKRSSAKSTTMSKPLTLADITDGRSSEKTRLVTDCSPEDFADPFCQFMRENPTVWHVADYFKKKLSERGFSELSERDDWVGKMKPGGKYYVVRNGSCLAAFTIGRAYRPGNGFAMVGSHIDVLTARLKPVSTLASKAGYLQLAVAPYSGTLGHTWWDRDLSIGGRVIVSERASPSPSSATTTSVRLVNLDWPVAKIPTLAPHFGVGGFGDVNKETQAVPIIGLTGDSGGVASCEDEDEDEREKKEKKKSEKKPLGPEGSFVNDQPRRLVELVARQLGLKDPSSIVSWDLDLYDSQPAQRSGLDREFISSSRLDDQLCSWSAMVALLAAEDDEKAGHVRLVALFDNEEIGSLLRQGARSNFLPLLVERTIEALSSSSSSSSSSAPSPSSSSSPNNNNNNNNKASLLGQTYARSFLLSADVTHAGNPNFLGHYLDKHVPRLNVGLAVKTNSNGHNTTDAVSDALLHRVADLCGSKLQRFQIRNDSRSGGTIGPALSSAMGVRSADAGIPQLAMHSLREMTGALDPGLGVRFFKGFFDHWEKVDAEWEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNP0</accession>
    <name>A0A367LNP0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNP0"/>
    <dbReference type="STRING" id="1330021.A0A367LNP0"/>
    <dbReference type="OrthoDB" id="5288318at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="373" mass="40190" checksum="D9ECD1A3377878CA" modified="2018-11-07" version="1">MTTTTTTTTTIHVHVAAAVASHIDLNTLDALARVSRGLHDGLIQYRGGLLGATLRCSNEASPVNRDELLRHRARASNWHYVDHGRSFNGKSGNCAHDMVQECRRCGEVNCAIKLPPRRLRERHRRLCLACARAPLALLTRPTLLPDTPLDAEAVQRAVCTCDSKAVWLCQPCGRGIRSADHEYQRIWRWRNHYGEMLGGLGTGIGDGDRGVVCGREQDCLAARDREQEVDCDAIDARDAPRSPDRSDPASLPSPHPDDHDHASSLSPSPSPSSFSSSSQLGGGGGGPGYRRHEIEGIGGRVKCKLVRTVRVGACVPEWDDEKIGAAADGRILVPEVKAAARSWCGWCWRVVPGSKDLAAGDAEAEPGGGLSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPH0</accession>
    <name>A0A367LPH0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_2628</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPH0"/>
    <dbReference type="STRING" id="1330021.A0A367LPH0"/>
    <dbReference type="OrthoDB" id="1158011at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23799">
        <property type="entry name" value="UBCc_UBE2J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000058">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="4">
        <location>
            <begin position="5"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI16344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="266" mass="29248" checksum="7950BDA4F9E54BE0" modified="2018-11-07" version="1">MATKAAQKRLTREYMTISENPPPYIVAHPSESNILEWHYIITGPEDTPYHGGQYWGTLMFPPDYPFAPPAIRMHTPSGRFQPSTRLCLSISDFHPKSFNPAWEVSTILIGLLSFMTSDEMTTGSVSTTSAEKKFLAARSRWWNSTGGGSLTRGNPAQKGNVKAGDGGAKFRAEWPEIDTENNEWMKKMKVDLATGVRLDGDSGSSCGPQLNMGVTSSNQTQAVVDAVVQQRDAGRGWIYRNKLLFAGGVLFLYVLIARIVRGDGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPL9</accession>
    <name>A0A367LPL9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPL9"/>
    <dbReference type="STRING" id="1330021.A0A367LPL9"/>
    <dbReference type="OrthoDB" id="4800057at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022190">
        <property type="entry name" value="DUF3716"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14312:SF1">
        <property type="entry name" value="BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTOR A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14312">
        <property type="entry name" value="CREB/ATF BZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12511">
        <property type="entry name" value="DUF3716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="678"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="920"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="487"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="684"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="926"/>
            <end position="943"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="943" mass="104785" checksum="84D2B15DF42F142A" modified="2018-11-07" version="1">MSTTSPARPDESAAWTSLPADEQRSVWDETENKFWHGFDHEQEALRANLENNYQKMTLGVRVDLGELGGRRAMLADVRDRLSQELARIDSEINRIVNACEAKAARLIAMEQSYRKTEQDRLENRDKVVRKMESFFRDKRGGDGSSRDRSSRCLPMPILPSPHEQRSPRHALPVNAANRPLHGHPPPPPPPPLAQAQQAQAQAQAQAQAQAQAQAQTQAQAYAQAQALSKATSSPLETAGARHPVPPQKPPRSNMCPSDGELVDVIDADGNFLGPVRRIDPWNQWVREIQELPIVRKVKIRRGRKFTQEHLASIYDRSEAKGVRWLSCMIQATGEIQSQRCHSCDKNQGAFDDCVIVGGPLFPKCGNCEWNRQGCHIPLVSKSNNAGLPVNGRPWKRPLEVHQLDNAAATNPERHPKESLGARAADVAQAVIESVRQRPDESPVKSEPVTQMPTPREPREHLFGSTAAMNNGLSASGSPPPSRDIPTPSAASADGSPDGSPMTLEPLEEITRENLGVPLAKIDQSHPYWELGWPNIRSVIEPQLESWREKNLAALQATARGEGGSAKFQTGRQVNRGARILEFLDRGDISPYQLLGKKYTHTGKGAITSYDTLFRLCETLSELAKFNLDVTPVEWLRHRLHEIRLIKGPNFNVSKTIHDFYHDPKLSALRVKNGYKSIGRPSGYKAAPSGTPSSASSKKRKSMHSLVGTPRETPPAADVINRSPVSVDDGSTAAMDPPDTPSDARPDKRPKANSPPPPPSTATMTTTAPEVQSPPAVDDSDKDSLSGAPLTGKDWRLYQVKSRLYTSPINVTQYWTWQEKDRLFEHQVLGSAEPVSWTVHRDPIDFHVRLDDILEVRWNVDALQVRLVMSSSGATVAKQDGKPRGDVMTAFKRENTIRRFLAFCRDRKLRTVEVTADEMDAQWGEMQSERLPRNDDEASKELKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQF1</accession>
    <name>A0A367LQF1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_2907</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQF1"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI16617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="205" mass="23597" checksum="CA6E94BD64A352A3" modified="2018-11-07" version="1" fragment="single">PSILARAPMPKPPCILLSSVDTGTCRISGSMARRLGNKIKRWYLRGAKQHQHTVCTWLPIIMQGWLRAPCQGPDAQPRLIILQRLSPQPGHWIQSLNAETASASYSRCSFYFKSEQRATMRFFSPIARAHASHPKRWLTFFWRYPYLDCPYPVAFVFSRLRLSISVYLSVCLRRLVTEDEFDARAAGTSAKTRECDRKRLDLTHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQS6</accession>
    <name>A0A367LQS6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3135</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQS6"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="266" mass="29903" checksum="17168DCEDB8FA699" modified="2018-11-07" version="1">MVRMTPSSNTLNFNIAQGRTDFAVETKKKGSLVIEKLRHILFLLTFVIWVGREETGLAATSHQLISYIPTYVYYVYTRHKMTVVSYPWRRGLGIKNGNQPLRVIQAALILLRLTPSSNTLNLEMACARKTLVSDGPIYRKCSWISSSAVAAAVDHIVRATVYGSGTLDQVPEAQEVVFRHVAALCAAEEAAVLRRPDAPHDRRRQATKEGSKASAKKMNFKQHSDRSASGTAKSLLVRVTIDIGRFEYDTKKKKKKKEVLWLREQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQV6</accession>
    <name>A0A367LQV6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_2539</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQV6"/>
    <dbReference type="STRING" id="1330021.A0A367LQV6"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000188">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF50">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="45"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI16799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="499" mass="55304" checksum="04B4248B790726BA" modified="2018-11-07" version="1">MDRKPRPQDEAIVEEDHDHALQTESPHVVDHAAERRLCFKFDTRILPVLTLLYLFNALDKGNIANAQTKGLSKDLNFLPGQYNIVLSIFFVPFVLFAPPIALLSKRFGPALALPTMTLVFGSVTILTVTARSFGGILALRWILGMSEAAFFPVLVYYLTTFYRRAELARRLAVLYAASNLANGFSGLLAFAIFRLPDKGLLLLYPWRYLFLIEGAASVLLAIVAFFLLPRKVVEARFLNEEERALASRRIRLDSSADDDETRRRRPLSDALRVFLAHPSALAFLAIEICLGMPLQAVALFLPQIIQRLGYPTVQTNLLTVAPNASGAVVLLVLAFASDASRLRFPFIVLAFALTLTGFVVYAAIDDVEASLRLAYAATFIMCWGTSTPSVLLSTWYNNNIADEGRRLALTSVGVPLANLMGLVASHIFKERDAPKYTPALVTVACFGASGGLITAGLGLYMMIDNRRRNKRAGVCLRARDVPTQWLREGPSVEEFRWFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LR19</accession>
    <name>A0A367LR19_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(+) synthase (glutamine-hydrolyzing)</fullName>
            <ecNumber evidence="3">6.3.5.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">NAD(+) synthase [glutamine-hydrolyzing]</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_2518</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the NAD synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.1" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LR19"/>
    <dbReference type="OrthoDB" id="2020662at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00334"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003952">
        <property type="term" value="F:NAD+ synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009435">
        <property type="term" value="P:NAD+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07570">
        <property type="entry name" value="GAT_Gln-NAD-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00553">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000036">
        <property type="entry name" value="Glutamine-dependent NAD(+) synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02090">
        <property type="entry name" value="NadE_glutamine_dep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014445">
        <property type="entry name" value="Gln-dep_NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003694">
        <property type="entry name" value="NAD_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00552">
        <property type="entry name" value="nadE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090:SF9">
        <property type="entry name" value="GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23090">
        <property type="entry name" value="NH 3 /GLUTAMINE-DEPENDENT NAD + SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="11">
        <location>
            <begin position="4"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="708"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1288"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1050"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="767"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="801"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="820"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="857"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="888"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="945"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="955"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="976"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1007"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1288"/>
            <end position="1297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI16869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1431" mass="158059" checksum="7B265A0EFEB2A68C" modified="2018-11-07" version="1">MKLVTVAAATLPSVPLDFLGNRDRILESIRLAKETGAKLRTGPELEIPGYACLDHHLEGDTFLHSWEVVADILSDEVCQGMLIDLGLGVRHRNVRYNARVLCTFGKIFCIRPKMALANDGLYREARHFTAWSKPREIETYYLETAVQRVTGQKTVPIGDMILSTQDTAVTCESCEEMFVPLNPSIFTGLNGAEIILNSSASHAELRKLRTRLELIANSTRKLGGIYVYANATGTDGEARMLHDGSSMIIQNGEVLAQGSQFSLAPVQVTVATVDIEKVRSYRSSISRNVQAAQQPDFPRVECDLVLSRDVEDIWLSNQPEITQPIELHVLNPMEEIHMATAVYLWQYLTRTNSAGFFLALSGGLDSSTVALFVYGMARLVLTSINAGEGPTLRDLQRVTGDKDFVPSTPESIVGRLLHTCYMGTVNSSKETEDRARRLAGMIGAHHSSITIDETVAAHEAMVDKALGMTPRYEVEGGTRSENLAKQNIQARSRMVVAYSLAQLSTTARKLPRAGSPLLVLGSGNVDEILRGYFTKYDASSADIAPLGSISKTDAKSFQRWAREKWNLPILTEFLEAIPTAELLPLSAGVQSDEDENEMGLTYEELSVFGVLRKVDKLGPWSAYLRLLSDWRDRPGYGPRQIAEKVFRFFRFYAMNRHKSTICTPSIHLCPYDPDDNRHDLRPFLYVVDWPWQFRKIREHVERLEEQLSKRMPVHGDQPSEAAAPRRKRPSFASPTKSSMARFNPTIVERRRSASPAKPEGSQPAARRGSESGSDRSLSELLTPHQPAEKVTAASEPDSRDEEMRNQPEKRSTGTTRPFPAAKPNPRPLPAPAPEGEDDLNPFIGHTLRRSPVTGVSMPPPPEPELPPSVPDPMLTTPPRGIHSSPSRWKGKSKAKRNSPLKVPAEPPLEAGPGNEAEAESSRRPPAAEPSNEPGQEASQKAGAEPSKKSEGEQHTRKRSGTGSRKKLTAQPGSKKPGAEQPKKSRAEPSKKTGSESGKRSGAENSKKSSGSPSGSPQEADPPCDFALDPTTNKARRVAAHGADEDKLRERDQLQMEITKLKSDLKTASAENERLRLMQTSGRTVAPVDEDAVMDLLRRQFLSGDGACRPDLSQQLTQAILNPMALLPFGRPSHATQTDEGGEPDKIKSHHPVSMTAEEELPYLELFTPFSVESSVAVLPTKPGRPLRQRRMVTLRSRDVPGLFTAKLEMTVNATSLSITDLTVTSLEPSARFELKPFVDKICSGDCNRTMQRNVGLVSWAMAGWYRVAKQRSLFWLRLERNLGSPDKALEAATEMRESRRRRRQKQQEQHPEDEDEAEPSVKTGDRCAMADLMRYLGQQALEIRVPAGRGSDGDECLLRLEWKIDFDWTGEAQSKVRTLVGVPGKWREADGRGVLGKVPKLFEDLVDGGQDGEEAVRTMTALLAGTQGVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LR41</accession>
    <name>A0A367LR41_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF155 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_2185</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LR41"/>
    <dbReference type="STRING" id="1330021.A0A367LR41"/>
    <dbReference type="OrthoDB" id="18302at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF15">
        <property type="entry name" value="SPORULATION PROTEIN RMD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="DUF155" evidence="4">
        <location>
            <begin position="238"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="82"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="85"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI16913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="462" mass="52226" checksum="DB5C79A950807B2C" modified="2018-11-07" version="1">MDENTPLLPTDGRPRNPRTVTFNADPVTRTIEADASLTSLNNKLRRRYSHGSGVPQALPPSVVAKIGPQRSTKKTEKLKLLPNPDLEDGQEDEESGRDVYSQYTRIKDPTARRDAARLGKSDRARLPRVTAYCTANRYDMDGLMRFFKGRGKTRGANPKLIDECIYTPYAYVHGPESLPSPHRRHSTGGESFDAKALRQTAPPDDVYHDSAAAAADDDLPALEPTPEFDVQVHTPEAFLFDYGVIVVWGMTEAHEARFLRDIAKFEVEKLAPDDVETEHFNFYYTHEYQARIYNDFITLRDKHNYMTKLAISHALAQSVKTSLFEELIASTVDTCKDIPTQIALTGKINLSRKQINMQIGELFILRINIHLNGSVLDTPELFWVEPQLEPVYQAVRSYLEMDQRVELLTERLDVIADLLAVLKDQLSHGHDEKLEWIVIVLIAMEILVAAVNIVVDMWAGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRC8</accession>
    <name>A0A367LRC8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_3105</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRC8"/>
    <dbReference type="STRING" id="1330021.A0A367LRC8"/>
    <dbReference type="OrthoDB" id="1507364at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000069">
        <property type="entry name" value="ER associated DnaJ chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051100">
        <property type="entry name" value="DnaJ_subfamily_B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015399">
        <property type="entry name" value="DUF1977_DnaJ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908:SF3">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09320">
        <property type="entry name" value="DUF1977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="137"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="90"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI17006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="442" mass="48373" checksum="38FC8174F5AB2FAA" modified="2018-11-07" version="1">MTKKNVLPSFQDRGKQAPLAPASRGFKVASLTSHPSTDTVVSLGLSSIARLPRCATPSTTNQPAPNLLLSSPSLPGRSFRPLASRLLFPMPGATASGASTGDASARSREHRQGNQGRTYTVEQKEAVLRIRKCNATAFYDILSLESVRTSCTEADIKKAYRKLSLLTHPDKNGHEHADEAFKMVSRAFGILGDKEKRDKYDRFGTDPDSRFASAQAQNPFAGFASRQASGGMRGRGGAWEDELSPEEMFARFFGGGGGPFGAFDTGPQFVFNFGGGPGIRVHQFGGPRPRRRPREAEPGEAEQQAAGNLQNLIGLLPIVIFFILPMITSLFSGSSQTPQMVFDYPEHPYTQGRVTPNLGVSYFVNPADVASLSHSKLSKLDRTAEISLVRRLRYDCDSEIQSKQQMRQDAVGWFYQDTDKMARAEALQTPSCERMRSLGISR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRG7</accession>
    <name>A0A367LRG7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">laccase</fullName>
            <ecNumber evidence="4">1.10.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">L249_1828</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17594"/>
            <dbReference type="ChEBI" id="CHEBI:17977"/>
            <dbReference type="EC" id="1.10.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.2" evidence="4"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRG7"/>
    <dbReference type="STRING" id="1330021.A0A367LRG7"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13854">
        <property type="entry name" value="CuRO_1_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13880">
        <property type="entry name" value="CuRO_2_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13901">
        <property type="entry name" value="CuRO_3_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000021">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000038">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000046">
        <property type="entry name" value="Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF502">
        <property type="entry name" value="MULTICOPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016952493" description="laccase" evidence="14">
        <location>
            <begin position="19"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="17">
        <location>
            <begin position="139"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="15">
        <location>
            <begin position="263"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="16">
        <location>
            <begin position="471"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="31"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RCI17043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="626" mass="69758" checksum="DF0CDBFA66603845" modified="2018-11-07" version="1">MRQLKLVLFPLLLTSAAATWDRPADLKPWHPHASRDSDHYTHKGVVSARPSYEEEQEEEEEGGGEPCGQDNDDQYPSRPSDQTIGDKYRWMPNQHGACAGNTPTTRSQWCGLSVDTDYTTVAPTTGVVREYWLELTDVVIAPDGVARTAMAVNGSIPGPTIFADWGDEVYVHVTNKLYNSLNGTSIHFHGIRQNFTKQSDGVPSITECPAPPGETRTYHWRAVQYGSSWYHSHFGLQLWQGVFGSIVINGPATANYDEDLGAVFLSDWDHRTVDELHPAAELEGPPFLATGLINGTNVFGDGGQRLNISFEAGKSYRMRFVNAAIDTHWKFMLDNHKMTVIAADLVPIQPYTTDVVAIGIGQRYDVIIQADQQHVADDFWLRAIPQATCSRNNNTDNIRAVVHYGPEARTPRTSGYNFTDGCEDEDIVPYVAKDAAESPLTTSVLANLTTLSDGRFRWTLNSTTMLVDWGNPTALQILDGVTTFAESNAVIQLPEPERLFSMVIESDLPIAHPIHLHGHDFFVLGQGNGRYSSENATLNWNNPPRRDTAMLPGAGFLVIAFETDNPGAWLMHCHIGWHTSEGFALQFLERVDEIRRLINETALRDECRSWNEFQQRFAVNQTDSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRK5</accession>
    <name>A0A367LRK5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Box C/D snoRNA protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Zinc finger HIT domain-containing protein 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">L249_2322</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts with FBL, SNU13, NOP58, NUFIP1, RUVBL1, RUVBL2 and TAF9. Interacts (via HIT-type zinc finger) with the RUVBL1/RUVBL2 complex in the presence of ADP.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the BCD1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRK5"/>
    <dbReference type="STRING" id="1330021.A0A367LRK5"/>
    <dbReference type="OrthoDB" id="190098at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051601">
        <property type="term" value="P:exocyst localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23023">
        <property type="entry name" value="zf-HIT_BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.190:FF:000001">
        <property type="entry name" value="box C/D snoRNA protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.50:FF:000006">
        <property type="entry name" value="Exocyst complex component sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.70:FF:000005">
        <property type="entry name" value="Exocyst complex component Sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.70">
        <property type="entry name" value="Exocyst complex component Sec6, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057721">
        <property type="entry name" value="BCD1_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010326">
        <property type="entry name" value="EXOC3/Sec6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042532">
        <property type="entry name" value="EXOC3/Sec6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292:SF1">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21292">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT SEC6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25790">
        <property type="entry name" value="BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06046">
        <property type="entry name" value="Sec6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="18">
        <location>
            <begin position="10"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="340"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00077531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RCI17048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1194" mass="135144" checksum="7FE6FC251CAA02D2" modified="2018-11-07" version="1">MADPLLSTLCSVCNAAEPKYTCPRCQRRSCSVECVKNHKARSSCSGKRDETAYVPVSELRTVKGINHDYNFLQKLGLSMERAERLLIEDRGLISRQELRPETIQVITWKKGRDGRSYKVLREKPAAMPAKQTRSESLLHNKLKQLGIEVVRAPKEMTRRKENKTIVSRRSGVICWQVEWLTVWDEGERGAGMAKRVLSKVTENMDLGQAYRLASLQNGLGGGKEGVEVREEEPLADWWLGGGINSSTMLMMQEPSTGRWIDIKEDGDDEEKTTTTTTTTAFHFFLGPPLTGSAAMTQVTAVDPGDTLRDVLPGTKVAEFPTIYVLRRGQKFPPWLELKPRDEAAKRQTKRKAVGGGGGGDERRAKRVTFEQSFDDDGCDGMEEDVVEEEAGEGQIEDGEMEDEEMEEAAQHPSIILDSERHAPRRAIMDDGPVPKLSDLLRHPEDLDKIPALKLEFSRKKGAVDSQLRTGLREQLDTTQAGMTGLGDGQKTVQLIKDEMINIDRLCSESQTMIRDFASINLVSQAHRNFGAVEAMRRDLESFSDRLLVVEDMLRQDDDDKENMPNLLPCHYELTQLRNMRDDATEQVQRLGEEADPGLATTLDDYFGRLDETIDWFDEHVGILAMNLISLVVNENNGLVVRFAVVMDAEERSDRRVLALQEALRDHQDMAARFRGITDGPKKVRGYKQKFIEAIRIGAEQQLEQARDEFLDDASRLDKAMKWYYNDLNAVKMGMTPLVPRRWNVTKTYVDVYHGLMHDFLVGMMDDGETSSAHTLEIASFPEKYYKKMAKLGFRPEDLTPHVIDNREAELVDGFRKLIVKFLDEWIDRILAQEKRDLAERGTAEGSNLDQDEYGYFRTKNLVALWRMLREQVDAAANSERADVVEGVVDAMFLRLRGRQQAWQRMLEDEATAACEAAAAAAAATPGARDAVVDGFQALQDWLVATANDQIACVDDNEDEGRLGYLSSFRQKVESSVTAGYLERADDEVASLRDGYLDLSTWCINRFAQLIFAVDFKSVMSDFFTPRWYSSATMKQISATFDEYVSDYRQVLHHSLVDIFVEILADELLVRYLSCVRNKGAKFRRSDPFRDKIFADVATAFDFFASLPNPDVGHSIKQTWRVTEPFLRLLDADRDSLPDAFADFKAAYWDLNVAWVEAVLRSRDDFDRAMLNAVLARAAQIDLVRGPETIMGRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRR9</accession>
    <name>A0A367LRR9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_1860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRR9"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI17144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="71" mass="8169" checksum="40919B1CD3A14CD9" modified="2018-11-07" version="1">MGLIDRATYVSTFISVCFHPLLQVYAFSCFDNVIEAALVMRVAPCYQRKGMKRMKKEGFTMHGVRQSRSMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRY0</accession>
    <name>A0A367LRY0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Fringe-like glycosyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_3112</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRY0"/>
    <dbReference type="STRING" id="1330021.A0A367LRY0"/>
    <dbReference type="OrthoDB" id="414175at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000036">
        <property type="entry name" value="Putative glycosyltransferase family 31 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10811">
        <property type="entry name" value="FRINGE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016736057" description="Fringe-like glycosyltransferase domain-containing protein" evidence="10">
        <location>
            <begin position="41"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="11">
        <location>
            <begin position="294"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="54"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI17169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="581" mass="65689" checksum="897C80CA08D147FB" modified="2018-11-07" version="1">MMGVKLPGPKRATMRSPFLRALLAALCVLLVLMAVMRSDSVPVHNHLFGKGSLKSSLAQQPQQQQPPQIQQQQNQQEQDQQQRPQQHHKQQHPLENKKRPFAHLPFLNAERPVTTSPPVINCTVDVPHLTEIKQRYELDEKFQYLKRYVRFTRQEGLERKRITKLSGDLLPGALTTVDLTKQYAHEACLAPLEVPVTASGMPSTVNASDFMFGVSTTYQRFMDSNTTPINEWIFWLTDGLGHSNGGKLLLMLLDASDEELQEVANLLGDVGIDVDVYHSNSAVEMAVRYLTLVPTLYTHSDAHKKKWLVTCDDDTFFPSMHGLIKKINSYDHTRQMYIGTLSEDVGAIERHGSQAFGGAGVFLSLPMAKLITERFGLCTSEQKVLESNSGWGPQGDIMLRKCIYENSETRLTSVWDLWQLDFFGQPAGFYEWGIKPLSLHHYRGGGWHKAKPGQFTKIAHTCGEDCTLQRFQTADNFVISGYSIAHYPQGIDFDINQMEATLHAAPENKGWNLDFMFGPQRPALERTGRKIAWELQESDVRSDGSVLQTYTRKKNDGRWLNKNGQSMSNIDGVFELVWIPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRZ4</accession>
    <name>A0A367LRZ4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_2102</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LRZ4"/>
    <dbReference type="OrthoDB" id="3182339at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022099">
        <property type="entry name" value="DUF3638"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022105">
        <property type="entry name" value="DUF3645"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046541">
        <property type="entry name" value="DUF6606"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051346">
        <property type="entry name" value="OTU_Deubiquitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367:SF34">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367">
        <property type="entry name" value="UBIQUITIN THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12340">
        <property type="entry name" value="DUF3638"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12359">
        <property type="entry name" value="DUF3645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20255">
        <property type="entry name" value="DUF6606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DUF6606" evidence="10">
        <location>
            <begin position="15"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3638" evidence="8">
        <location>
            <begin position="2024"/>
            <end position="2245"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3645" evidence="9">
        <location>
            <begin position="2369"/>
            <end position="2401"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="562"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI17130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="3011" mass="341450" checksum="59127164A7CA07AF" modified="2018-11-07" version="1">MEGRTESEEALDFFINHLFLPPKLPGGDDSTPAKESALIELVLDALTQFLPEADADCETAIVAATSLIGNLRTARDKDGVLQKTGVLKAFDDVASSEAAAAFQVTAQNAAVLLRKADGSAIFEFFELSPTNSAALASTGRLVRRFPATAIRLSQHVFEQSEFQSVVATTLVKMSIQPVSDMKHKVAKAKQKHDEDRDTTDPRLVTELLMSFLGGVGEQIKIDPLCKNTREDVIYQKSMLLPWRRSELWLLIRVSLQLTMKRAAGDSAHVYKPFVAFLLSRVLKKAVRKEAPSDILGIMTAKICRRLKKLQHPRDGKWLESIGSAVSEASLLMSQRWQGIQHCSEPQLDMTALASLEMNKDDLIPLGIMDGFISSISQRSNQKGFDFSPVAGISPLDVDELPSGFEDAEEAYKPFHLAAVESWVVSNLDAWVERWDVDNESLYRELYDLMRRYHATASQWYADRPEGISRMHLVILELWVAADKAAVEAIPLLKDYDPKIPVQMYQALLLSFKDDMARLQRAESYVEERKRTAQSRNKPSIFTSFGHGDSFQVQYGRRSQQHQDLMRRILDDARAQRRQKENEFRSLKSRHDDLMDRYNQGSCQEVEWVEDGIRYTEHDSHCKRCQLRKQARKLAILVHEWPLSDDGNEALSTVFELAVPPVFGQWRDATLYLLVDVLQCDNSSSRPQTDYTLRNQGDLSRYAPPQHDWRVRLQSETKPHMITHRKAKAIGSSTVSQICLNNGLRLQYVDRRLGVVLGMFAPSLALADRCAFQLPGRSAAALQRFLHRTYLKPNGATSNQVIASQSQCPTHMTLSEYKALAELPFGYRTQWMSVLRQLAMPEVDFNKTETAIFLLQISLQAGPNASGTVARGSHSRLCDEQFGKRMHEHLLATVRRMSENWESYIALWSCTFLAARLLSMVADGLRSPFLRILHMSRTILRQWLATMRQRADEITDGKQREEFQRSMLDIHLIQAETFNVQDELLTHILSEPQQSSVLVEASINIYNNANLLRGTTQSPQGIMHGRWMHTLHRALPIFGKAIKAGWGDEILNLAIKRCWPAFTAEVEWRPVPTARHWFETTSSQLKVHLNLLTGQLLVDGRPLSRLPPGYEAHADYRRLFGSSVLDVMPSPLPGLHFCSVTTFEDCKVHFGRQDDETGDGDLLVRLEKDGKFLELVPPRAFRHVLPNCFVHDYAHWYDCDSETVELRPLSEPWTHRDDNWTLSLHGSSWRLTRGQHVSLLHPGSNSARQIASILSPLESDLDLFMCFDRAADAVSIELPRLQLGFRLRRGRSVIVSRQFLGMQIDADQSIRTLLGFRSKLVLRDSRDGQSRKVIIPRGHVQYHGQQYGQHGKHVASSVSYGSARRVEVYRIDNLLHQLKDNGKVESKLYLAYLHALTSYCLPDMFTGLTGTEQALEMLQSASVRSINCLSQAALDTLKAIASLTPGRSYYPKDQKVMQTIAWKSDLSFAARDSRYYKAVQCLLDRTSTIEFLHPSSNEIKPLLLEHAEMHLVEREIIRNAGRCVSGYGAEDFISKRDGFYDASRDGIRRADRTNRVRDIVHRVDGGLVSLPIEVADDLVDHLYSLLSRGRVEGDVALRPKLEYDSAWLEDPETFLSSLWCPLHYAIQRDRSFMGKYETMMWLATLSYANNHDAQVTQALMMLFLPPRLYPTAIPLGTSFALEEGYTHDVVRDRLYGIINEAALPLDRCPERKLPALPGEKSRTTLRRRQREHSSHSHAAVVAFRDQLAYQWPCAWPSQPRGHKIYIDGHKAMELVVPKWKVWHDNLLFRDYLKSFVDRLRDLPLKFVFIPLVFEAAQSSPMSHRGFESVEDTLANPPSAIVSPSSSGLGRFAKPQAQTLEDPHEKLAQMISSLELDASSGYAKQYLAELNDSISSLDRFRTLDEEDALQERTMSLQEHLELCEGRVMDIYRSLSDTIRSSPSSDAASQAIRAILVKAECFPRVCPILFLKHLRQVSFSRLSSSSWKDAVIAYGVAITLTQQARRLVKLQDNEVDLDRELENTGRQGWDPYDHPEWLLLECESELMIRKVQTQIAQEMIAPPNKQNAVMQLNMGEGKSSVIIPIVSVALGDGSQLVRVIVAKPQAKQMYQILISKLAGLLDRPVYQMPFSRAIRMDAQRAGAVRQLADRCIREGGVMMVQPEHLLSFQLMGLECQNAGEDEVASHLLNTLRFFDRSARDLVDESDENFSVKFELVYTIGLQQPIDYSPDRWAVIQEALRLVAEFSTKAKSEFPHSLDLDHQHVGRFPRMRILRVDAQDAIFSRVAASICSTGLSGFPIARQPRKVREAVQRYITKLLLSAEEVSAVENCSFWDDTTAKAIVLLRGLFACGILAFALGQKRWRVNYGIDDTREKKTRLAVPFRAKDSPTPRSEFSHPDVVIVLTCLSYYYGGLGDGDLFSILEQLVRSDNPEVEYQDWVKTAPDMPQPYRQLKGINLRDRTHCELQVFPHLRYSKGAIDYFLSRMVFAKESREFPHKLSVSGWDLGKAKTKPMTGFSGTNDSRYVLPLDVTQLELPEQQHTNALVLEHLLRPENSIELVPHQVGRSAFDSGTLLAMMGRMTKNTRVVLDVGAQIIDLSNREFAAQWLHQHRDDDSTQAVVFFSDLDELLVLDKSDNVEELQTSPFATQLDQCLVFLDEAHTRGTDLKLPANYRAAVTLGANLTKDRLVQACMRMRKLGKGQSVVFCVPWEVENKILQQQGRRPPMKSTLTVSDVLGWTIRETLLDLRRTVPLWLTQGSRFYKQKAQWDVFPGDEVGSHRRVQWAKGFREKEAQTLEDHYQPGKAHTSLDSLIQTVEEKSRELLRRRCEDFGLVRLQRAAALQEEQERELSPEVERVQQVELPPAVKAAVHAISHGIRDFVVKGRIAERPVGLKPAFQALGGTSAAEYLDVAEFPCLFWVTNDFISTVETSRENGSHSDSFQRGVQWVLTNTTRNGAAQLVLISPYEAQELLPTIERSEFVTLHLYSARKSLEMASLDRLTLYTFATRWDSLGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LS49</accession>
    <name>A0A367LS49_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">HMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_1791</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LS49"/>
    <dbReference type="STRING" id="1330021.A0A367LS49"/>
    <dbReference type="OrthoDB" id="432719at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000002">
        <property type="entry name" value="Copper-transporting ATPase 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056236">
        <property type="entry name" value="HMA_PCA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01511">
        <property type="entry name" value="ATPase-IB1_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46594">
        <property type="entry name" value="P-TYPE CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46594:SF4">
        <property type="entry name" value="P-TYPE CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24534">
        <property type="entry name" value="HMA_PCA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="457"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="492"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="526"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="674"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="715"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1019"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1049"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="9">
        <location>
            <begin position="272"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="147"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="155"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="200"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI17062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1075" mass="114441" checksum="AA9615725685CEEE" modified="2018-11-07" version="1">MACGDVCCSGHHHDDEPMTPPHHACCDGSTSSSYEGENEEEPCDGKNASLPPLLSRATRHVKAVSLPAQLFLTYKPHTHITGTTSSRSSTACSSHQAQALKQYSAFLKSARCICDGVLEHGWAKKTCCGGGDHDKIAGQEADETTDYRVLPGHDGRHHHHYHGAMKKRRQHHQHQHQHQHQQQHQQQHQHQHQHQHQHRLLASSASITTASSLPSSSCCSSSSTTVDGKKNMPTPFSKTNDDDDDDDDDDDDDNDNDNDDRFRDPEKGQGIEHVTLSVDGMTCSGCGAKMERVLKAMPGLSTVRVNFVMGSVDFDLDTSTTSLDRVMRAAERASGFHCTKMSSEDQTIDLLSHGSSAKALVDSGLLLSGVKEAAVLNGKVVRLTYDPAVVGARTLIRHVGPYSTGLAPPIDDPGLSTGRRRLRDRLIKTVASACFTMPVLVLAWSEKKLVDARTEGIVSLVLATVVQLIAVPDFYIPAIGALIHSRSLEMDMLVVISITAAYAYSVVAFAFSLAGKPLAVGALFETSTLLVTLVLLGRLVAAFARLRAVAAVSLRSLQATTAVVVEPDGNDREIDSRLLQYGDKVKMGPHATIPTDATVISGLSEVDESIITGESLPVTKKPGDDVIAGTVNGSGMLTTRLKRLPGKNTVTDIARLVEEAATSRPKMQETADRVASWFVPVVSAIAAVVVVAWIVVGLRVHGRGAGEAVANAMTYAVATLAVSCPCALGLAVPMVLVVAGGIAARNGVIIKSAGCTERSRKVTDVVLDKTGTMTEPGLDVINEQVLTTDYGGTVAVAKALVADSRHPVSLAVAKHLAENNPDIKPAAGLSDVRAIPGSGVRAVFKGKTIRAGNATWTETATHPAVVRLLERGLSILVVTDGAELVAVFGMRCRLRTETKAVVSKLQRRNIVVHIVSGDHKSAVESVAAQVGVSHVASRCSPSDKRDYVAELMGRGRCVMFVGDGTNDAIAVAQADVGVQLASVESCSEVTRSAADVVLLNGLEGIRFLLRISAVGFRRIVFNFVWSAAYNVLAVLLASGVLNGVRIPPAYAGLGEIVSVLPVILAAMTMLWKRID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZF9</accession>
    <name>A0A367KZF9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_1623</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000026">
        <property type="protein sequence ID" value="RCI07573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZF9"/>
    <dbReference type="STRING" id="1330021.A0A367KZF9"/>
    <dbReference type="OrthoDB" id="10016939at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22884">
        <property type="entry name" value="TOM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005683">
        <property type="entry name" value="Tom22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12504">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12504:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04281">
        <property type="entry name" value="Tom22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI07573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="144" mass="15844" checksum="36D03246A7567AF5" modified="2018-11-07" version="1">MVTLTEVEDEHFQASADADDDDFTDTDSEISNESDFDPSSETLAERLYALRDIIPPTTRGWVSSRVNSFSSKAWSVLSFSGKGIWVITTSALFFGVPFALSFAEDQQIMAMDQELNMRQTGTDLMTNDPEKSTTAAAGDAKSEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZW5</accession>
    <name>A0A367KZW5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_8333</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000027">
        <property type="protein sequence ID" value="RCI07512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZW5"/>
    <dbReference type="OrthoDB" id="4072826at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051531">
        <property type="entry name" value="N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792">
        <property type="entry name" value="GNAT FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00765)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="156"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI07512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="301" mass="34246" checksum="00A517B0C627601C" modified="2018-11-07" version="1">MQHARATVALSPASLQSTHTSVPSHTSVPSHTSVPSHTSVPCHTCMRMRMQHCRATPPSRELIGEGGMWDIRSEQTGWPIFGFRFKKEHWGKGYGTEFAKAYMEFWWEIERTVQEISVESASLVDISDESPIKATEQMYACTTMDNWGRSRQNALQKAGFKNWGGLDNGMVNWQMKSDNSEGELIGEGGMWDIRSEQTGWPIFGFRFKKEHWGKGYGTEFAKAYMEFWWEIERTVQEISVESASLVDISDESPIKATEQMYACTTMDNWGRSRQNALQKAGFKNWGGLDNGMVNWQMVNPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZY6</accession>
    <name>A0A367KZY6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_1587</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000026">
        <property type="protein sequence ID" value="RCI07532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZY6"/>
    <dbReference type="STRING" id="1330021.A0A367KZY6"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018244">
        <property type="entry name" value="Allrgn_V5/Tpx1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00837">
        <property type="entry name" value="V5TPXLIKE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01009">
        <property type="entry name" value="CRISP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016942225" description="SCP domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="36"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI07532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="171" mass="18674" checksum="2E5F90041CBF8C8B" modified="2018-11-07" version="1">MKKKALGLLALAAAAAAAAAAAPEPDPNFWWLDEQAFESAVISTTSHYRGEHGAGLVRWNATLAAFASWYLNNYNCAFRHSGGPFGENMAYGYPTPAVSVAAWGNEGVQYDYGHPGYSPATGHFTQLVWKATTDIGCARRWCGSQMQWLFACEYWPRGNVLGQFEQNVGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0B5</accession>
    <name>A0A367L0B5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_5879</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000023">
        <property type="protein sequence ID" value="RCI07883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0B5"/>
    <dbReference type="STRING" id="1330021.A0A367L0B5"/>
    <dbReference type="OrthoDB" id="272703at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12398">
        <property type="entry name" value="RRM_CSTF2_RNA15_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.70">
        <property type="entry name" value="Transcription termination and cleavage factor, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025742">
        <property type="entry name" value="CSTF2_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026896">
        <property type="entry name" value="CSTF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038192">
        <property type="entry name" value="CSTF_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735:SF2">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14327">
        <property type="entry name" value="CSTF2_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14304">
        <property type="entry name" value="CSTF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="8"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="87"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="87"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI07883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="310" mass="32624" checksum="E2507704C5D7502C" modified="2018-11-07" version="1">MSTRPPSRVVFVGNIPYGLSEEQITEIFSSVGKVERFRLVYDSETGRPKGFGFADYPDTAHSLDSASSAVRNLNDHEIMGRKLRVDFSNDQKGGDDDNGSHQPPSMLNSHAANGAGMTSQINSLPVLPAGKDIPPGLTCTDAISRTLNTLPPPQLLDILGQMKTLASSDPQRATELLQQAPQLAYAIFQALLVMGLVSPEAIQAVAEPGGPAPQAPPPPAATAAAAFPGAIPGYPVSNNTPPVGMAYAPPAAAAIPNYAAAAVLPQAAQDPDALIRQVMELPQAQIDLLPEAEKQQILALRATFAAQQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0C6</accession>
    <name>A0A367L0C6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PUM-HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_5852</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000023">
        <property type="protein sequence ID" value="RCI07893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0C6"/>
    <dbReference type="STRING" id="1330021.A0A367L0C6"/>
    <dbReference type="OrthoDB" id="497380at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012959">
        <property type="entry name" value="CPL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040059">
        <property type="entry name" value="PUM3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13389">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13389:SF0">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08144">
        <property type="entry name" value="CPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUM-HD" evidence="3">
        <location>
            <begin position="322"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="183"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="273"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="782"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="888"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="189"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="317"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="337"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="786"/>
            <end position="798"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI07893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="937" mass="104961" checksum="6E7E944D30C29ADD" modified="2018-11-07" version="1">MAHSGVNSIDVRQKLSSPKWKSPAWTQDQGKKHKRVWRRPVWQDYEKKDVGDDAKQPKGKDQLSQKSMGYSQKDLLTLDFGKSVGMERRGLGNEPVKVTSYSGSPKKAHGGSKMTTQNEIKTMKKKRPDQEGESDWREKMKETGTSLTFREAGSDPYVMRILREALAQDIEERKWAESWPFEQAVDSQPTRDDPPHAVRKNDLQQHGNHTDDDEKKMREVHRIEDELHQLHAKLDGFLGQLTALGFGEDVGFLSKQVESEIRKDSFCNLGQEHMSARPENAKAKKARLLSGAKPSNNNKKKNRDDDSDSDSDGGGVRLDDENKSKKASFDRTNLSSREAHAKQRQLAQERKAAKPLADQVHRTKKIWERLRKRSDVPKDERQRLVKELFDIVTGRCRDFVLKHDAVRAVQTAIKYSTPEQRLQIATELDGSYADLAESRYAKFLIGKLLAHNNDEIRDMVIPNFYGRVRKLISHAEASWILDDIYRTVATRDQKAMLLREWYGPEFALGEMNKDKELTAELKQILESEPSKRGPIMKGLLHLINSLVQKRMSGFTMLHDAMWQYFSNLQVGSEEFSDFLELVKGDESGDLLKNMAFTKSGARLACLLLAYGSSKDRKHLLKGYKDTMLVMAGDPYAHVVLLTAYDVIDDTKLVAKAVFPELIGDKDEEKAQNVVGAVNNANARTTMLYLFEGLSPALFPASHAFDVEMLREAAKIRKSTSKKDDNLRRKELVTALAPYLLAAIEAAADELTSTAFGCQFVTDVLLSEVDGKEKALEAVARCAGQRPEPDETSERRRQDISQTPFGGRMLKSLIQGGRFDKAAGKVVPVQPRLGFGQVLYPVIKDDVVGWATGPSSFVVVALLEADDFGEAEGLRSLLKENRALLEKAATEMTAEQKSSREARKKASSSDQGEGTGKKRGGEGGAVGNAGSRLLLEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0N7</accession>
    <name>A0A367L0N7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000024">
        <property type="protein sequence ID" value="RCI07782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0N7"/>
    <dbReference type="STRING" id="1330021.A0A367L0N7"/>
    <dbReference type="OrthoDB" id="2426273at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596:SF2">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G17550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="86"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI07782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="441" mass="49830" checksum="74EAE0A0FCA7E138" modified="2018-11-07" version="1">MTPRMDHRRCSFKICRAFQIEMSTYRPLHVQGACEGDCWTVDVDVVCVQSILRSTNSFPIMRLRWPVEERDELKLTIEPFQTGTSFAALSHVWADGLGNPQANSLPRCQVQRMARKIAALPDQSHGWFWVDTLCCPIEPETKTIALQRMADVYRHARHVLVLDSSLSAVNAEDTHPAELLFRVFGCSPWMRRLWTLQGTLITIAEGALAGSLQIQFADGAVGMMELLIKLSVAKDQDMRYERLNQSLCDDGHREACSARPPTTRSWESTSKVASWTETERTAYQRQQDNPLCRAIDAGDCGLVWSAASTDDSPRMCCMVRFLNGTGGKDGIARVRRERIVILAALGKTEIRVMDNMQLLADEVAEDCTMQELIRSNQLELARERIKRKLLTAWESEPCLKAALKETLGDDLEEETVWAMVPKLFSHYIVVVPLGEQLWAVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L137</accession>
    <name>A0A367L137_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Actin cytoskeleton-regulatory complex protein PAN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">L249_6221</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the PAN1 actin cytoskeleton-regulatory complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Actin patch</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PAN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367L137"/>
    <dbReference type="OrthoDB" id="120976at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00052">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057334">
        <property type="entry name" value="PH_2nd_LRR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216:SF173">
        <property type="entry name" value="ACTIN CYTOSKELETON-REGULATORY COMPLEX PROTEIN PAN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25353">
        <property type="entry name" value="PH_2nd_LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00027">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="14" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EH" evidence="18">
        <location>
            <begin position="1521"/>
            <end position="1610"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="19">
        <location>
            <begin position="1554"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
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            <begin position="55"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
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            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1066"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1180"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1389"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1645"/>
            <end position="1667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1679"/>
            <end position="1703"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1880"/>
            <end position="1934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1953"/>
            <end position="2003"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="2029"/>
            <end position="2487"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="16">
        <location>
            <begin position="1777"/>
            <end position="1804"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1069"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1084"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
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    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1269"/>
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    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1392"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="1651"/>
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        <location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="17">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
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    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
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        <location>
            <begin position="2222"/>
            <end position="2235"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="2253"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="2273"/>
            <end position="2283"/>
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    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="2288"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="2320"/>
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        <location>
            <begin position="2375"/>
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        </location>
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    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="2391"/>
            <end position="2440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00025194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RCI08150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="22">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2487" mass="271903" checksum="140AD37BB39BA06E" modified="2018-11-07" version="1">MNLDRRKWRSSSGLFLGQQPVGPQMDPNKKMKSDLPVVKTQRVFSRALRSLSSSSMDSMAATSIRSSSSTRRLQKTPSNASSMIERFHRRVSRDSSANGSVSESPGNPAADGSQPYSTMALLQYGPLKPDVSLLKARSEYLVLSDQCLVKFSSGEAARNAFPQLDKARAQARDASPYRHAPGRSSSSGEARLDIPLHAIVAAFVEDTPGYRSGIEIWWFSPWPRLAYCRAHLHFALSRERDDWLASIHRAYRARLRKGPATYLIPDNLKARIEHIVRAGEGLIDETPQVSIFPVARRVFGSHQKQSSADEAHDNADSSSFYFVIGPCMCHFVEALKADHSTLPGDLRIKATSHGTVTLTRFKASVASHEQRFVVCFRSPFGPESRLDLASVQYRRVIEALTKADRILKPMWPQHFQQVIFDIRGLPPPLQLTSGNDLGGLKRSLQAYCAAYQVRVPEWKIEWNTAPQPAFRLLPPTGEKYSSLQLLAVFRALRYNSFFKAISFCGVDLSPLAGKVDHSQYGDAVAYRSLNGLSITEDQHEVLLQAPILEREMHALTFASESIRSIDVTDVLGGWGQSRSSVTSELVRPMLILWRQQLCVCHSISLSGNPLASQDVDELTNLLDQGPIHFKKLHLARCALGDTGLLKLWKSLASQAYSLEFLDTSDNQGSVRFETIQSTLRRMRRIKRLVISGNTRIASDGALLDETTMSLWALEELDLSGIPLNDKTVNVLASYLGSGQSQDLRAMRLNNCGLTGRQISRLFRGMGQARRLTLHLGGNRLDEGIDDLCGAIACGYGPWSLFLQMVEFAQEMNYIKLMRALTVNKTVECLSLAGTAMTDAASSTACQAVSDFFSKNNTVRFLDISGYDCKLDEGRLGKEFSRALSGIRRNTRIEHLRVRSQMLNVNIGDLAEAISANKAMQTLDCEGNDFNLSNFRHLSKKLLDNLTIRHFSAFSDQELSRTMRKSVLSADTDAPTRRQSVMSKFLSDKSQVCKEKLAAQQLQDQWDCVKSDLEGILARNQGLFEVKEQARSGFSRGAGRRDSDAESDFVSAFGGLAQKDFDARRAHGYQGSTSPTRQAMSEAAVVERPRDDAERPASMASCEVAVSPSTDGASTPDAPSPPELESPADGGFGFEDGRNAVTVLDEARDAILLRTLFETHPRTGAVVLSCKHAAMYSNSSAFLGGNSQRPGGPQQHQQQQQQQQQQYGGTPFNQQQQQQPFAPQPTGFGQQPQYTGYPMQSQPTGMQNSQQYGGFSGQGQQPPPMPPIPSQYQQQQQQPQFQLSQPTGMISSQNNSLSFITAQDQDKFETLFKSAVGDSSATMTGEKARDLLTLADTTRAGELYFPEFALAMYLCNLKLSGKSLPPALPEVIKNEVASVVDMVGFSVVDDQSKSSNNNSSSTAAQQPQQPPDSQLLHLSQQVTLGCSIRSLPATVPKVPWGPMPTGMGQSMGGGMGMAPSLNAQPTGRPGQWGLVNAPASGLPNIDVLQARMMPQPGREAGSYTTQGLQGNAVIPWAITKEEKTRYDSLFRAWDGLGKGHIFGDQAIEIFGQSGLEKPDLEKVWTLSDNGNKGRLDLDEFAVAMHLIYRKLNGYPLPNALPPELVPPSTRNFNQSIGTIKSMLHQESDMRKTTGASLLPQKTGVSYMKNRSFRGDTGRSASGRKDATVFRNDDEEFGYRSSARRRMGNSAVRSESPSSVASGDDMTIEQLRKKIKEKQVLLDAMDFDDEKNAEEDDVLDRRDRRQAEELYRRIRRLQGDIDAHPNAPAAGGGDSDAERRTLMRQLQNLTDKVPELASQVRKTEKAIMEARLELFRIKDAKAHPGSGAPIVGTGPGGSVTESDRLKARAKAMMQQRTAALTGKKMDAAPEDLDGPKRLEEETIKAKSEKESNESMVRDVEESVGDFARGIGDSLKEGPRDNNSSEHEKRRWEEGLGVEDEVRDFIFDLERESRNARLRAREKRPSQPPPSTQDSRPPERAASPQASSSPSPAPQNTAGGGGSYASYKTAEERAAFIKQQAEQRMAERLAALGIKAPSSKVGESASQRAEREKSERAAKLKQAEEEDARREAERQARIAEEQGVPPPTAAAAEPAKTGPKRPPPPPSRKATKADNSEGTQAARAAEEQRLAREHEEQQRETQEMEETAKEEEDEFEKEQKETEARLKALEEQVRQGKLKKEEEKKKKKAALAEAKEKEEKMAARRAEIEAAKQREVELQRQLEAMDGDGSSDEGETQEQETREVPEAKPNSPPRTVVTSPPAETTESKNPYFKMMSQPSETATSSAVAPAPDGPPQPDPSTNPFHRMTQGNKAAPRSGPVTRKRADSEDWGSDKDDDEDSEDDERPGGGNAAQLASILFGTMAPPRPLSAAGRESRADSPAPAGEEAPAAEPDSSPPVPTSSAPPPPPPPPPPPGPSAGAAPPLPPPPPPPPPAPAPAPPAPPGAGEGPSAPPSGGRPAGFLGEIQMGKSLKKTSTKDKSGAAVAGRVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1A5</accession>
    <name>A0A367L1A5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_6289</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1A5"/>
    <dbReference type="STRING" id="1330021.A0A367L1A5"/>
    <dbReference type="OrthoDB" id="428293at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006862">
        <property type="term" value="P:nucleotide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044712">
        <property type="entry name" value="SLC25A32-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45683">
        <property type="entry name" value="MITOCHONDRIAL NICOTINAMIDE ADENINE DINUCLEOTIDE TRANSPORTER 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="10"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="103"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="222"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI08196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="310" mass="33580" checksum="DB94B20FCBDA926D" modified="2018-11-07" version="1">MPTTSDAGLSPATVESTAGLCAGTVATLVVHPLDIVKTRMQIHRGKRPTTMAVLRSLSSTAQPLASLYRGLTPNLVGSAAGWATFFSAKARAERLLAGPGGNPSAGETFVASAGAGAATAALTNPVWVLKTRMLSTDRGAAGAYPSMAAGATAVWRTEGWRGFYRGLAVSLLGVSHGAVQFAVYEPTKRMYLSRRKRRRRRRRRQNDDDDDDDDDAYLPTEATMALSTGAKLVAGAVTYPYQVLRSRLQNQWADERFGKGIVAVVANTWRMEGIGGFYRGLVPGVVRVMPATWVTFLVYEKVKYYLPRMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1D1</accession>
    <name>A0A367L1D1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7082 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_6344</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1D1"/>
    <dbReference type="STRING" id="1330021.A0A367L1D1"/>
    <dbReference type="OrthoDB" id="1751210at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055509">
        <property type="entry name" value="DUF7082"/>
    </dbReference>
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        <property type="entry name" value="MEDUSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39463:SF1">
        <property type="entry name" value="MEDUSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23305">
        <property type="entry name" value="DUF7082"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7082" evidence="2">
        <location>
            <begin position="426"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="588"/>
            <end position="655"/>
        </location>
    </feature>
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            <begin position="667"/>
            <end position="687"/>
        </location>
    </feature>
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        <location>
            <begin position="703"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="627"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="675"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="742"/>
            <end position="760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI08207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="767" mass="82510" checksum="6257D8833DA421D6" modified="2018-11-07" version="1">MPLSLLRIGTVLRHYQDLFIAPLSSSSPDSFMSAVKFHSPSYKLFEPEYHTDKPIIVGVDTRFESPDTVTLRYEEAARAANGGDPRRDSPPTVLEMAAYSKAQLPSMHGYSTRYPDTGGYDQYPAPSFSSQQTADKFAQLNQQSFASNNAVAQYMPAGPTVLSCHPSSGMFGTKVFIKFSSQYDLFSMSSPMPYFYLYFGSEKCPVHDVAREAQDSSGFVYSCGADAPQAMVTGCSSNSVPLSLAIEGPSGEETSRTAAGSFQYLEGSGDDITRTGKLPKHETSAAGPQGDQASGSSPKAVVDGHLPTEAATNSYEYPSQPPQYGAEFSQANGDMISTYRSTSFTDPQYHRRTAPGWSGFGATLGSTGRSSVLDHGGLGPGRPGLTPLPMPSSASPGTPQLIRTSTIANGTGSSGPYHPISLYSSKAVLKITGKLDTMAENWTQEEWDNRRRIVMFRKSQTGSTLTASFRAVPVNERPPNSICISCIWWAEKAECYVTSVDTIHLLEQLVAAPNRFSVEEKNRIRRNLEGFHPMTVSKAKADSEEFFKVIMGFPNPKPRNIEKDVKVFPWKILESALKKIIGKYSASPSSTLPPANMMTPVSTAPYAPLPTPPGQSMGSQHGGDPQSHYSSQHESMPSPRSLSGSQPPWTPYTTAPTYSTAAARTLSPNMRHGSPQPPPPPAPPMRISTTPLPAVTTYDSRAGSTGAYGTSGMHTPISHHPTSATPPRWDTASASYPDPYPSLTSHHGSSGQSVYGTSTYGDGASRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1I5</accession>
    <name>A0A367L1I5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8344</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000020">
        <property type="protein sequence ID" value="RCI08300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1I5"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="55" mass="5882" checksum="1EBC9608322B07B1" modified="2018-11-07" version="1">MGIISISFSHLLNTNTSPASNSSSIASFRLSRDSSSSSLLRDYLPDSSTLHPLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L238</accession>
    <name>A0A367L238_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_8841</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L238"/>
    <dbReference type="STRING" id="1330021.A0A367L238"/>
    <dbReference type="OrthoDB" id="8026949at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47103">
        <property type="entry name" value="DNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47103:SF8">
        <property type="entry name" value="DNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="7">
        <location>
            <begin position="130"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="7">
        <location>
            <begin position="152"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="7">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="7">
        <location>
            <begin position="322"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="7">
        <location>
            <begin position="350"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="7">
        <location>
            <begin position="415"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="7">
        <location>
            <begin position="436"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="7">
        <location>
            <begin position="460"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="92"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="518"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="536"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI08475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="545" mass="59614" checksum="6C24CE0C0B24B8C5" modified="2018-11-07" version="1" fragment="single">PIAAAHLAVINPLSLLSRVFPSFVFTSHLAASLDFFVFLLLLPSSSSRSEAWLHPFFFCFITAGFPPPLPRLCSRSVESKRNIASPHSIMSWDNTPAPAASAPSADDAWGSGAATATEHNGQDHGPDSTKCFSCGEMGHRAADCPTPREMTCRFCHQPGHMVKDCPDKPPMKCENCGQDGHMKYNCENARLINRDHIATISPEDAWAKIRSAVSDRDIDDVKDAVQEYVKALDGTVTYRDLQEGLINDGINLFIIPMERPLAPVFTNMDLQGNMGKKYTVSYRFSEKPNRPREAEAFPKSREELLARLEDAGEAVNSGRSLCHNCGELGHTTKHCTQERMDKPDGPKIACSNCGEEGHRLRDCPQPRVDKFACRNCGYVKVILYCTCVVLTMDNSKSGHKAAECEEPPNLDNVECRKCNERGHFSRDCPQAGPRGCRNCGQEGHIAKDCDQPRNMDNVVCRNCEKTGHVSRDCPEPKDWSKVQCSNCHQYGHTKVRCQQAPSDSDAFASGGFDADTNVGSGPVDGAGDAGWGPAATSTASQSGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L245</accession>
    <name>A0A367L245_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L245"/>
    <dbReference type="OrthoDB" id="3540210at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="554"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="658" mass="74090" checksum="25F1D1FE2045F7EA" modified="2018-11-07" version="1">MSTLRSGPDTGLGALDYQVKLGVWTDWSHGSLMGLTLTLNRNEGSILIAVNALFISVVAASFWRIARLLLHRHLSTPEPRDALHHQRQALLRNSTAAFSTVWSFLQLGWAWRRRDGRAWIRTLPVTACIVLSIVAFTAASILSSRLSSADGVAVLVDGSKCGRFDHYRPGTEWDLQYGNLPPCRNTISRYAQQCYADNVSSGILCCRNFVKNRLESNINYEAPCPFEGSICRSNTSNLMLESGLIDSLDDLGINAPARDRFKIRHRMHCAPLTTEPYSAYSIDNYTTYAYETWRNDSQHAVTTLAVPNLGSQAMSYRFVPNLSDNILIPELEKADGGLFLMFLSGNGVSFLNRSSDLWYRTLLPDDAVSVDGGASYHPDVAASPMACKVQVQLCNAQSQCGPLASWSDALGSASRQFRLSPVARDMFLDDASHRPNGSYNRQDTRWAWFQRSMYISSAGLEHMVNFQQGTALASYDRFDGRFMHPIPDHQWKIDMVRLWSYMLASMQMSPLSYASGQDVMGLRFLRDAPEAFKKELCENQVCLSKVVSTAYSSFNLVGLLLIYILGLIIITSSYMIEPMYEYCWRRKHYKEYKFLEWSAEETLQLQRAAYQGIGSGTWEGLTHFVPTTDKDMPLADLTALYDDGRDVNPQSSRREEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2J8</accession>
    <name>A0A367L2J8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="18">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">L249_8887</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 18">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="18">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="18"/>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2J8"/>
    <dbReference type="STRING" id="1330021.A0A367L2J8"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051403">
        <property type="term" value="P:stress-activated MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07856">
        <property type="entry name" value="STKc_Sty1_Hog1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000049">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000046">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008352">
        <property type="entry name" value="MAPK_HOG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038783">
        <property type="entry name" value="MAPK_Sty1/HOG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01773">
        <property type="entry name" value="P38MAPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0010">Activator</keyword>
    <keyword evidence="9 16 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 16 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="12" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 18" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="19">
        <location>
            <begin position="20"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RCI08442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="364" mass="41765" checksum="D9EA6F713EAE3577" modified="2018-11-07" version="1">MAEFIRAQIFGTTFEITSRYSDLQPVGMGAFGLVCSARDQLTNQNVAVKKIMKPFSTPVLSKRTYRELKLLKHLRHENVPVVPSFALAVRLLTGKLSYFVTELLGTDLHRLLTSRPLEKQFIQYFLYQIMRGLKYVHSAGVVHRDLKPSNILVNENCDLKICDFGLARIQDPQMTGYVSTRYYRAPEIMLTWQKYDVEVDIWSAGCIFAEMLEGKPLFPGKDHVNQFSIITELLGTPPDDVINTIASENTLRFVKSLPKRERQPLKDKFKNADAAAIDLLERMLVFDPKKRITATDALAHEYLAPYHDPTDEPIAEEKFDWSFNDADLAVDTWKIMMYSEILDYHNVDSNPHAMEDQSFIKCES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3C9</accession>
    <name>A0A367L3C9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI08936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3C9"/>
    <dbReference type="STRING" id="1330021.A0A367L3C9"/>
    <dbReference type="OrthoDB" id="415532at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="10"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="100" mass="11502" checksum="7A1305849262BB27" modified="2018-11-07" version="1">MVGKWMQNFVISVCWSSCGRWLITGSKDYTFKIWDSQTGLQQMSIKAHREYGHRRGRRFVTGGADQLLRVWRHIPRVAVGDAEEDLCGRLEKVNVSSSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3D5</accession>
    <name>A0A367L3D5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="5">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_4923</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="5"/>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI08939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3D5"/>
    <dbReference type="STRING" id="1330021.A0A367L3D5"/>
    <dbReference type="OrthoDB" id="407432at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050265">
        <property type="term" value="F:RNA uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF40">
        <property type="entry name" value="POLY(A) RNA POLYMERASE GLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="12">
        <location>
            <begin position="156"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="11">
        <location>
            <begin position="787"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="24"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="108"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="843"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI08939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="964" mass="108302" checksum="65DC39FD946AF2A0" modified="2018-11-07" version="1">MASENLDALAATSLENRLRGLVLASNSHNDAQPSSDQSPRASKRRPNQAERRQLSSQLSIPIDPRPHYQQAHQDLRHKPQHFDHSHYRHPPPTVNNSLQQERNNRPHFHQRSLYDPGSSQPNRRHGPTPGDIASQAEFLDALCYRVVSQSEIDVVEIGEKETFRRHIEAVCRHVISIHEPEQHFPAESVELKCFGSLSSGFATKASDMDLGLLSPNSIPQPDAAESPIPRLLEKAFLDAGLGARLLSRARVPIIKLCQRPSESLLQSLVAERQKWESGEENCVQDPADDDHETASPVRGVQASNHAGFNTDPSSHTEVLDENGETGCYQLQQGADSSLPSYYALAKRVLRRAGGRDVTISNYHEFTDSDWSTLDGVCKAFVHGLSDPLLQGRLARYPSLSFQPIRNLPNHRSLLGVYTQVEGEQLVQRWDNWSAKEALQSFQAQTDQALATWNRIQSMSNLGVDPVSFNRDLQLALEKIKLIPSFQLLLLEQGQHEDLAQYYARAKVILVNLRRASRGSFDAVQQLLVRQYVSGIAQKDPRNMLSKMVDNYNGQVDFEIVSLWHKGLHMSRRLEEAIKQDKLSASQAANAKEYISLLQSSPCKILTGPADYKFVIPVPPEVVDLVMSIRQLHHLVTVSSQPQKRYRDPLEFPTTGAGVQCDVNFSAHLALHNTALLRCYSFTDSRVRPMVLFVKHWAKVREINSGYRGTLSSYGYVLMVLHYLVNVAQPFVCPNLQQLAPPPPPNPSAAEVEATICCRGCNIRFWRDERQIMHLAAANQLNRNGEGIGHLLRGFFEYYAHNGIMSTGLAKGFDWGRDVLSLRTQGGLLTKQEKHWTGAKTVVEQQGGGSTASIQQAPSRDKQLKRGAEVKEVRHRYLFAIEDPFELDHNVARTVTHNGIVSIRDEFRRAWRIIRNVQGGHSQEDLLQNAKDAQEEVVDPFLKLMDDIHGPVRTWMVVDRGRGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3I3</accession>
    <name>A0A367L3I3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NAD+ kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_4894</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3I3"/>
    <dbReference type="STRING" id="1330021.A0A367L3I3"/>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000008">
        <property type="entry name" value="Putative NAD+ kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF11">
        <property type="entry name" value="KINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G12870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI08772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="545" mass="61437" checksum="B6F625EC850ADBD6" modified="2018-11-07" version="1">MALLEEEKRDQGEECVRDDDGDDGDDSKAVEVTFDPANPYRRKASLVSSEAMLPRAARRDQCLVHQFLDSQRRAKDAGDGTPTPIAESPVPSVPAHQRATLHPNSVDAAYVGQADQQAWTRQMTTDRLPELDTYPFDDAVHSRMLTKKQLSDMAWGVRELSRRLSSMRIRFRVKTIFVLAKIHDRDLIAKARDLTRWLLDSERDVPYVVYVQDKLQANKTFDAARLVEEVAASYPDDETSRAAVGRRLRYWDDTMCRSRPQMFDFVVTLGGDGTVLYASWLFQRIVPPVLSFALGSLGFLTKFDFDDFAPTLDSALDKGFTVSLRLRFETTIMRSIRRKPLTNGGDGHSDEDEDAAHRQRDLVEELIGEERDDEPSHRPDGTYEILNEIVVDRGPNPTMSYTELFGDDEHFTSVLADGICVSTPTGSTAYNLAAGGSLCHPENPVMLLTSICAHTLTFRPIILPDTIVLRVGVPYNARTAAWASFDGRERIELRPGDYVTISASRYPFASVQTEGRRSEDWINSISGKLGWNTRQKQKGYKEWDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3M3</accession>
    <name>A0A367L3M3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_4915</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the membrane magnesium transporter (TC 1.A.67) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI09031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3M3"/>
    <dbReference type="STRING" id="1330021.A0A367L3M3"/>
    <dbReference type="OrthoDB" id="44756at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053279">
        <property type="entry name" value="EMC_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018937">
        <property type="entry name" value="MMgT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28144">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28144:SF1">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10270">
        <property type="entry name" value="MMgT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016562078" description="Magnesium transporter" evidence="7">
        <location>
            <begin position="23"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI09031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="15468" checksum="66122760B238D2EF" modified="2018-11-07" version="1">MTWVSRCVTATGLLLLAHSCYSAHEHAALSLTSSIFGHSSKNHQPIIKIPLDICVETVVATIMLCLGLVLGSQRLRPIKWHVWAGKVEREGAAGFLDGSGKVDKEYRGNPFAALESRPGFINIRQQRREFAQRSQKVSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3T1</accession>
    <name>A0A367L3T1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI09081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3T1"/>
    <dbReference type="STRING" id="1330021.A0A367L3T1"/>
    <dbReference type="OrthoDB" id="3550599at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="471" mass="52337" checksum="64A11452AC79CE57" modified="2018-11-07" version="1">MPAFLHLHLLPRHRFNLGRLIIRLNSSINLNMLLQKASPWTVVTLEQVSSSMLEYLPWLREVLLGGWPAAEELDTMQRRQMEPGSSLPPQTWTKGRDAQLAGGEERLQTKRALDPQPGGRRTARKSVRSVLFTSLARKGATPNVAQAVASDSTADATKDDAVTDAARDAAREAAWKAVTNAVQEATRKNGTSDATKDIASSVPSQEITPAAVHAPLVVPEYHEDDRKNFHIVRVPRRRHSGPNSCAKTVQTGTDPSPCAAPHQEPTAQVVPTPTAKSMKKTFEAAAFDAGVYSQAGAGKPPAGVTIQPRQEARPSCAEDDRVYVHANPAIHRSHNRSEEWHKEKAREIKDRGGRKAWSGKVVKRVQWTAHVQESLSKDKGERRTTPQPRTFSRPLDFGDVPESKLPDDVLKNPAWLKACEWFRKMKRLQDHRERAARRSEHETRQFYGNVVARKRPIMGEDGSAATRARTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L412</accession>
    <name>A0A367L412_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L412"/>
    <dbReference type="STRING" id="1330021.A0A367L412"/>
    <dbReference type="OrthoDB" id="3660917at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="334" mass="36565" checksum="234A82B58D1174CB" modified="2018-11-07" version="1">MEAGAGNQVPPEPQVSQHQKELGKILKGIKHDVTLLGVLSLGKDGVLRSLTADRQVVDAVALSPPLIKAMLDRTPFNPQNEIDYRGVDGREVPREQWFHPDKHLLPPPLVVSDERRAEAEAKVEENKKWLQERAEEDHDPSMKSALSLRFLCQVSAFLLPLASASPAGTASTLRYVSGSVSDVANGMKFTDDSVFTLGSDGVLRTFSKGRDVLDYRQLDPEQARDLAAKQVDAWERSGKPVPDSVMTLAHASVDGRLVTDIDQLLKPKEKPAVADDEVSVSQMSRRRSPGKLFRRAGPRICPGSPGCSSLADCQRHHCNACFFPHGPPHGTCFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L443</accession>
    <name>A0A367L443_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ornithine decarboxylase antizyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_1489</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with ODC and thereby sterically blocks ODC homodimerization.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ODC antizyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L443"/>
    <dbReference type="STRING" id="1330021.A0A367L443"/>
    <dbReference type="OrthoDB" id="5959761at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008073">
        <property type="term" value="F:ornithine decarboxylase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045732">
        <property type="term" value="P:positive regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0075523">
        <property type="term" value="P:viral translational frameshifting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002993">
        <property type="entry name" value="ODC_AZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038581">
        <property type="entry name" value="ODC_AZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10279">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE ANTIZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10279:SF10">
        <property type="entry name" value="ORNITHINE DECARBOXYLASE ANTIZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02100">
        <property type="entry name" value="ODC_AZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0688">Ribosomal frameshifting</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI09178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="275" mass="30120" checksum="3BBC10CAAE1991D0" modified="2018-11-07" version="1">MAPMNYQTMNCSSRYGEDAVASRVNVLASCYVVDSASNLKGLHYCTTGGRSGIPEVPTSGLPSPPTSPPLAALTSSNKLALLPKNKKRDVPSRRRGGAAFVIREECERFFCESMKTVFRGERDLSMYGSGLSDAFVQTPPPEDRIAAALKNGTDLCQATVHVDAWMEVWDYAGGASFRAFAVDDGEDKTLFVFFDSQGVMGRDLKKALMALIELADGPLECGRIMTCIDRNIPRQEALELTRSLQWVGFEMATLDHWAGDLDVTSPDWVLMGMEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L459</accession>
    <name>A0A367L459_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1429</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L459"/>
    <dbReference type="OrthoDB" id="2565191at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022793">
        <property type="entry name" value="Rrn10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28054">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28054:SF1">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="266" mass="29319" checksum="FCD581B4B2AF044B" modified="2018-11-07" version="1">MTSASGSEGEPRELKIGRRRVATVFDAVEGTVLPGSFIFNTNVVTEYSFRRQPLTPDEVLFRCNKAPQRYEEYDIYRAHDDLPQGGHGVLPDSDMLRAIHSYVRRFYKSVARGKTMNANERSMDETALLAFGILLEEAVTEIFGENGDLVFTERAGADGDELASRKKGGGKSPEEKGKKGSAIADDADEVVAQSSNDRGVSDVGTGGDEVVAGCHVNTDRKGSKRRWSDESDEDEAQQSVPRIRSTVREVASKRAKKRAKKRHAFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4N8</accession>
    <name>A0A367L4N8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="6">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_3668</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="6"/>
    <dbReference type="EMBL" id="LKCN02000015">
        <property type="protein sequence ID" value="RCI09394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4N8"/>
    <dbReference type="STRING" id="1330021.A0A367L4N8"/>
    <dbReference type="OrthoDB" id="59470at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016971">
        <property type="term" value="F:flavin-dependent sulfhydryl oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.310:FF:000002">
        <property type="entry name" value="Sulfhydryl oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039799">
        <property type="entry name" value="ALR/ERV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645">
        <property type="entry name" value="ALR/ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12645:SF1">
        <property type="entry name" value="FAD-LINKED SULFHYDRYL OXIDASE ERV2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 6" id="KW-0274">FAD</keyword>
    <keyword evidence="2 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="8">
        <location>
            <begin position="84"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI09394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="211" mass="23564" checksum="6C2232B31899A03B" modified="2018-11-07" version="1">MARRQHITLVLLLSLAFFFSVSYLYSGPGSLNARDAARLLNKVRTGQSQEALSGVDSKAPFQPDLSTLPEALLDGESIAPKLENATLKAELGRATWKFLHTMVAKYPEKPTPEERKTLQLFFVYFGQLYPCGDCARHFRGLLKQIPPQTGSRNSAAGWLCEVHNMVNKRLKKSIFDCNKIGDFYDCGCGDDKKDGKKDGDKDSKTDLKKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4U3</accession>
    <name>A0A367L4U3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_3755</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000015">
        <property type="protein sequence ID" value="RCI09428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4U3"/>
    <dbReference type="OrthoDB" id="4920338at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI09428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="380" mass="43624" checksum="4E5A977E7761E35E" modified="2018-11-07" version="1">MASTSSLVFGAIESIRRLLRNYLCKRQVSLFSKQANYTSWLSYACSIRAFKDVPSLLNLAMMHAVRMALSLAVLLPVRADDWQVRQCITHDDGELRQLLPQFLRNASSCARSKLAFGTIMCAERRIPREHRALFSPLIETIEDWEQYFQLDLQSAFVRYSDAKPRPELDRWTAYDRLLDLWTVTGELCFYTSVPSLADRIHPQKAGLLTLFYRTDTVRHQGQSLSYDIRQTLRNLRPPSLKIGGYGWKYEGAVACAAQLGAERELQVTAIKEMIQRAAEESHTEESRQRIALYYRDHFSTDSFLQAVVTGWRDTYVCPRGLDCQPTMAKGMPFLPAETHSYLQRLYYLLQMQSGVCIVLKRTATLVSDRYYVAVTTPVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4V9</accession>
    <name>A0A367L4V9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_3736</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000015">
        <property type="protein sequence ID" value="RCI09451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4V9"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016901335" evidence="2">
        <location>
            <begin position="17"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI09451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="86" mass="9098" checksum="111CF45B62352A9D" modified="2018-11-07" version="1">MKGLVIALLAIATATALPTPTPQLRKTKTAGPDEAPPAAEEKSWVMRLSCMANFSGNVAPACANLNPNQAPRRLPPQAATRYEVKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L570</accession>
    <name>A0A367L570_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L570"/>
    <dbReference type="OrthoDB" id="4848529at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="21510" checksum="706143B9AA1E93C7" modified="2018-11-07" version="1">MSQEVTPSKGNPWTEEAKIQFLLRIISQLREDGRTINWSRLGMEGRTTKSLQNMWTKITKEIAEMEARDAGEGSVGTPSKSKATREGTPVGSLPGGTIPLISFHLPAQKTARKPKKSEAWVAANGGLDSEDESPKKRAACEFIRCREQEVVMMIGGRRFVNVGSTAKGGPKTPRKKTKRSDSDDEEKSKGDKDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5D9</accession>
    <name>A0A367L5D9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_3889</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5D9"/>
    <dbReference type="STRING" id="1330021.A0A367L5D9"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF309">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="174"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI09618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="467" mass="51142" checksum="297B4AF1858090CD" modified="2018-11-07" version="1">MKIVIVGAGISGCATYLLLKKHLPKPLSAEPHDITIYEAYDTDKDTTASGRSQGPTHSSTLVVGGGLGVGANGLNVLKRLDEDILCDVVRGGYVAPTMNMKSKWGTVLARLQPCGHGDGDVENGMNMVASSRHWLWRCLRTRVPDDAIVTKRVAQVVANSHGRNLIRFADGSPPVEADLIIGADGLKSLVKEALFPEADGDPFPPHYEGLVGVGGFIPSSEVRDLVEKGSMNYVFGGNGFFGYFFAESAESAPYGDSPFHVSEPGDSLGWWSTYSVAECPTPETLDPDAVNRQLRERHKDWKDPVVQKILESVQVKNMYPTWTVPPLPTWERDGVVLVGDAAHALPPTSGQGSSQSLEDAEALTLLLCHHLRKAYQEHKTDVTSCKELITMAAKQYMELRLPRVTKILHDAQATQSSKRDMTLVKEYTMYMMLWIMGCFPSLMAKPLKAVIEYNVAEEVKKTLGKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5V3</accession>
    <name>A0A367L5V3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ribokinase</fullName>
            <shortName evidence="11">RK</shortName>
            <ecNumber evidence="11">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L249_4031</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate.</text>
    </comment>
    <comment type="function">
        <text evidence="11">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27274"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27278"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-ribose + ATP = D-ribose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="11">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HTP reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the carbohydrate kinase pfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="11"/>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5V3"/>
    <dbReference type="STRING" id="1330021.A0A367L5V3"/>
    <dbReference type="OrthoDB" id="545910at2759"/>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.590:FF:000010">
        <property type="entry name" value="GRF zinc finger domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032854">
        <property type="entry name" value="ALKBH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="Ribokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212:SF4">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="14">
        <location>
            <begin position="229"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="995"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="734"/>
            <end position="736"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="762"/>
            <end position="766"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="879"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="921"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="962"/>
            <end position="967"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="989"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="991"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="994"/>
            <end position="995"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="995"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="1023"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="1029"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
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    <feature type="binding site" evidence="11">
        <location>
            <position position="1032"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="1034"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
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    <feature type="binding site" evidence="11">
        <location>
            <position position="1038"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCI09801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1046" mass="112955" checksum="CE18EFAAA18EF724" modified="2018-11-07" version="1">MDSFLAPSKRKSEPDHQDDEPTEIKLALLASLYPDVEQEMLLDVLAAHQGSVDQAAASLSTKKKKKTTTTTGIGQQSSLRKYAATKTTKRLKANKGTTLHLYDPEDVAEYTPCTIIHDFLPQEDADSLLRELLAEAESFERSTFKLFDNVVSSPHTTAFFVESLDEVRSQRDDYYYNGAKLTDVRRITPQLAKVKKTVEEAVNGQVQHRIVTRYPGGRKLRHQPAEPWRANSAFVNCYKGGQESVGWHSDQLTYLGPRAVIGSISLGVAREFRVRRVVVTEEEEEGEDGSSHETGAISIHLPHNSLLVMHAEMQESWKHCIAPALVIDPHPVAGNRRINITYRDYREAMHPKKTPRGGGKTWDGISGCAMPGTYREGRHVPCLNGPSLMMMGIRRTEEEEEEEDDDDDDDDDDDAIRFSAARLIFPAESAALLQRRLPPKTWTSDDRPFVTLTWAASLDGKLSVAPGVRTRLSGPESKAMTHYLRRQHDAILIGVSTMLADDPALNCRLAGADTAASQPRPVVIDPHLRWTPRPTDKVLVTSRSGAGLAPYVVTGVSASDVPPDSVDVLQRHGGRFLHLPSSPSSPSSSSFAPQGARMRLDWRLVLASLRAQGLKSVMIEGGGFVIESLLESRGLVDSVIVTIAPTWLGRGGGVGVCPAREEEVDDGGCGLRLCEVSWHPFGDDIVLCGRLEETTTMRSHLLLSSPLLLTCLPTYNPSSVMARRKRITVLGSLNADVVPYVAHHPLDGETVTATSLSKGPGGKGANQAVACARLSRLSTDGSSKDQDGKGETVEIAMVGAVGDDPDADMLRSSLSSAGVDVSGVQTRAEHNTGVAIVVVDSSAENRIIVSPEANHALGPSDDVVRSTGQDCDLLVLQLEMRLDTVVAAIMCSKAPVLLNAAPATKLLPRETYARIAHLIVNQSEAALLLSDDVSAVELETESGLGIVADRFLEWGVLHVVVTLGSRGVFYADSNNRRALVPASKVTVVDTTAAGDTFVGAYALAVVRAGPDGFDIDAAVREANRAAAVTVSRKGAQTSIPWGSELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6F4</accession>
    <name>A0A367L6F4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Dolichol-phosphate mannosyltransferase subunit 1</fullName>
            <ecNumber evidence="13">2.4.1.83</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L249_8693</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a di-trans,poly-cis-dolichyl phosphate + GDP-alpha-D-mannose = a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + GDP</text>
            <dbReference type="Rhea" id="RHEA:21184"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 13">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 13">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 13">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.83" evidence="13"/>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6F4"/>
    <dbReference type="STRING" id="1330021.A0A367L6F4"/>
    <dbReference type="OrthoDB" id="2603at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006720">
        <property type="term" value="P:isoprenoid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000036">
        <property type="entry name" value="Dolichol-phosphate mannosyltransferase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398:SF1">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="14">
        <location>
            <begin position="14"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCI10010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="245" mass="27446" checksum="318AD4D954BEB9E8" modified="2018-11-07" version="1">MATDKAPKPRDKFSVILPTYNERRNLPIVTWLLHRTFTEQNLDWELIIVDDGSPDGTQEVAQQLTRVYAPHVILKPRAGKLGLGTAYVHGLSFATGSFVIIMDADFSHHPKFIPRMVEVQRGGNYDIVTGTRYRSGGGVFGWDLRRKLVSRGANLFADTVLRPGVSDLTGSFRLYRRSVLERVIADTESKGYTFQMEMMVRAKALGCSVAEVPISFVDRVYGESKLGGDEIVEYAKGVFSLWLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6H3</accession>
    <name>A0A367L6H3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_4015</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the flavin-dependent halogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6H3"/>
    <dbReference type="STRING" id="1330021.A0A367L6H3"/>
    <dbReference type="OrthoDB" id="3340390at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050816">
        <property type="entry name" value="Flavin-dep_Halogenase_NPB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006905">
        <property type="entry name" value="Flavin_halogenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43747:SF5">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43747">
        <property type="entry name" value="FAD-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04820">
        <property type="entry name" value="Trp_halogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI09822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="60850" checksum="A256970A6399865F" modified="2018-11-07" version="1">MSVPKKCQVLVIGGGPAGSYASTVLAREGVDVVTLEADNFPRYHVGESMLPSLGTHLKFIGLYERFTAMNWFRKDGAVYFLNRAQPPSIIDFGTEERPDTHGWNVNRADLDDLLFKYAGECGSKTFDGTKVNSIQFEPCPDIKVHGMTAQDINPGRPVSATWSRKDGTSGSISFDYLVDGSGRQGVLSTRYIKNRTFNEGFRSIAFWAYWTGCKKPLPGTTREGYTTFEALKDGSGWCWFIPMHGGITSVGFVQNQKIATERKKKQDGSTKTLYMDTFNSYIKELPPLFEDAKIIEEKGFKTTSDWSYSASHYALPYARIIGDAGAFIDPFLSSGCHLAMTGGLSAAATIMASIKGDLDEEAAGAWHSKKQSESYFRMFLTVSAFMEQIWAQEKPVINDANEEGYERAIATLRPGTIINPPVLETNVMQGDVDVDDEKRISRVDINKVYDFCARAFDHFEEHETTAIHDRLKQKGIDLLDMNHDMFKLLKEFEKELSVQETRVLEKIRAGHLCMKYFGAGRTETEVVDGLQLNMVSGKLSVVPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6Y5</accession>
    <name>A0A367L6Y5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Crh-like protein</fullName>
            <ecNumber evidence="16">3.2.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">L249_8625</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell envelope</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <topology evidence="3">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the glycosyl hydrolase 16 family. CRH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.-.-" evidence="16"/>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6Y5"/>
    <dbReference type="STRING" id="1330021.A0A367L6Y5"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02183">
        <property type="entry name" value="GH16_fungal_CRH1_transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017168">
        <property type="entry name" value="CHR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF68">
        <property type="entry name" value="GLYCOSIDASE CRH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037299">
        <property type="entry name" value="Glycosidase_CRH1_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="10 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="9 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 20" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="20">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016696515" description="Crh-like protein" evidence="20">
        <location>
            <begin position="21"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="21">
        <location>
            <begin position="29"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="278"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="286"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="322"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="355"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="369"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="17">
        <location>
            <position position="117"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="17">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="18">
        <location>
            <begin position="26"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR037299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR037299-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="RCI10169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="414" mass="43429" checksum="5B39905742C6F702" modified="2018-11-07" version="1">MKSFSSTALVALASSALVQAQTFTACNPLQKKCDPDPAFGNKVECDFHKPCPAFNSQGANINYDDKGAAFTIKADGESPTIHTGNYLFFGEVEVEVQAAPGRGIVTSVVLQSDDLDEVNQILSYHHKIDWEWIGSKNNQVQTNYFSQGNTSTYDRGKTHPVANPAGQYHTYKIRWTHASVVWSIDGQPVRTLTYDEAKGGSAFPQTPMQVKLGTWVGGGAKSSPGTVEWADGKADFTKGPFVGYYRRITITDFAGKDAPATGGVKQYEYTDHSGSYKSIKTVMGHPNEDSKHAENGVGDGHDNGSSSHNENKSAVEENLTATSSSSHPSSTSNSTTSDSDSDSDSGSGSPSSTTMATVGSSSNATATLSSPRKSGPTSSSGSQPTIIPGSGASALPAAGLSLVVAAVAAHLLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L878</accession>
    <name>A0A367L878_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L878"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="135" mass="15205" checksum="DAB915D4AC790E1D" modified="2018-11-07" version="1">MTTCKSRNKGEREFSQGSCRSSAKDDERHDKKLYGYHHTGILYEFTYKLQQLLLPGGAALKLTRSRHRLLLVRLPKTHEKLSNLTSRAGFFGFDGGNDASTWASNGEGLLIFFCRETMAEARVPSSVTRCTQTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L893</accession>
    <name>A0A367L893_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">10 kDa heat shock protein, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_4444</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Eukaryotic CPN10 homolog which is essential for mitochondrial protein biogenesis, together with CPN60. Binds to CPN60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GroES chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L893"/>
    <dbReference type="STRING" id="1330021.A0A367L893"/>
    <dbReference type="OrthoDB" id="184876at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.33.40:FF:000002">
        <property type="entry name" value="10 kDa chaperonin, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="entry name" value="GroES chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00580">
        <property type="entry name" value="CH10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772:SF0">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00056825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI10648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="116" mass="12442" checksum="202D32491C5716EB" modified="2018-11-07" version="1">MVGCFGWRDGVEATTIRSIRSLVPLLDRVLVQRVKAEAKTASGIILPESSVEKLNEAKVLAVGPGALDKQGKHMPMGVAAGDRVLIPQYGGSPVKVGEEEYQLFRDGEILAKIKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9E7</accession>
    <name>A0A367L9E7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_5185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI11034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9E7"/>
    <dbReference type="STRING" id="1330021.A0A367L9E7"/>
    <dbReference type="OrthoDB" id="9984693at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033308">
        <property type="entry name" value="PGAP5/Cdc1/Ted1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315">
        <property type="entry name" value="METALLO PHOSPHOESTERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315:SF1">
        <property type="entry name" value="PROTEIN TED1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI11034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="577" mass="65348" checksum="C6ED2CE4B176EA2E" modified="2018-11-07" version="1">MLVAAYLRHGLRLLAPLAIACTIYLYLYPVFGGCAFPVQSRDSREAFERTKRLHWPFAGSASDHVADELVPFRLLALGDPQLEGDTSIPIAYLGILPHLKSLALRLTFRLEHPHLRDRIRMVLHDVIDLFLEDVPNLVESVRKRFDLFGNDFYLAHIYRTLRWWSRPTHVSVLGDLVGSQWIENREFEQRGRRFWNRAFRGGERVPDEVAAQPSSNYTIAGFLDGSTDESVWTRRIMNVAGNHDIGYAGDLTPERMQRFERVFGKANYELRFALPIRDPKVNATILDKEVNPGSRRLPPQIRVLVLNDMNLDTPARDQGLQDVTYKFINDAISSAPAVENRGQFTLVLTHIPLHKPNGVCVDGPFFDFYSPEEGGGVREQYLLSPDASKGLLEGVFGLSGNTGGPGKGLGRSGLILNGHDHEGCDTFHFINQTNGTTASDRSWEAARWTEARTRALPGQHMLPGRREITVRSMMGDFGGNAGLLSMWFNQSTWEWEYEYQDCALGTQHLWWLTHFLDLGVVLCAMLYPAVLALERRGVDIDGRFFRAMDWLRHRLEALGREGVKRFSTERVGRTAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9F1</accession>
    <name>A0A367L9F1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EKC/KEOPS complex subunit CGI121</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">EKC/KEOPS complex subunit cgi121</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_5187</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. CGI121 acts as an allosteric effector that regulates the t(6)A activity of the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators. CGI121 is not required for tRNA modification.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the CGI121/TPRKB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI11036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9F1"/>
    <dbReference type="STRING" id="1330021.A0A367L9F1"/>
    <dbReference type="OrthoDB" id="329139at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2380.10">
        <property type="entry name" value="CGI121/TPRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013926">
        <property type="entry name" value="CGI121/TPRKB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036504">
        <property type="entry name" value="CGI121/TPRKB_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15840">
        <property type="entry name" value="CGI-121 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15840:SF10">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TPRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08617">
        <property type="entry name" value="CGI-121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143870">
        <property type="entry name" value="PF0523-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI11036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="195" mass="21845" checksum="B44A8FD623266D4A" modified="2018-11-07" version="1">MLETVSLEHVPSDFEIHAALFLNVRNAAFLHRQLLDRNADFEYAFVDASNIISRNHLFSAVFRAIVAHAKGALDTPNVHSEIVAYLNPSNNIADAYRRFGIQPSTVHLAVIKVTFPTDARPERPSSQAIWHHLTTNVDGDAVSPTNDNLETVTHMARVRKNYKIKNLSWLPEGQELARRSELEALILGTMALRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9H4</accession>
    <name>A0A367L9H4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9H4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="105" mass="11572" checksum="C2E5FB7F4B917E16" modified="2018-11-07" version="1">MLWDGFVVAERESESVVISARAASSISISKAYHQSWRLQQFGRSTMSDPRDGGWAVMKRTPPPPPRRTPDDIGGGWLAPRDGERSAFLARGSQPGQDDEDKDNEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9I3</accession>
    <name>A0A367L9I3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_7186</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PpiC/parvulin rotamase family. PIN4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9I3"/>
    <dbReference type="STRING" id="1330021.A0A367L9I3"/>
    <dbReference type="OrthoDB" id="1911748at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043323">
        <property type="entry name" value="PIN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45995">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PpiC" evidence="8">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI11091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="109" mass="11940" checksum="FB315E1896E68E49" modified="2018-11-07" version="1">MGKSTKKDEGKKDEAKANKAGARSINVRHILCEKHAKKEEALAKINDGIKFDENKGSLDPQFEEVAFALEPSTTASPKIGEVKTGFGYHIIMVGRPICNHADDRLLSDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LA08</accession>
    <name>A0A367LA08_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-hexosaminidase</fullName>
            <ecNumber evidence="7">3.2.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_7310</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.</text>
            <dbReference type="EC" id="3.2.1.52"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.52" evidence="7"/>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LA08"/>
    <dbReference type="STRING" id="1330021.A0A367LA08"/>
    <dbReference type="OrthoDB" id="428480at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016231">
        <property type="term" value="F:beta-N-acetylglucosaminidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030203">
        <property type="term" value="P:glycosaminoglycan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06562">
        <property type="entry name" value="GH20_HexA_HexB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000063">
        <property type="entry name" value="Beta-hexosaminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025705">
        <property type="entry name" value="Beta_hexosaminidase_sua/sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015883">
        <property type="entry name" value="Glyco_hydro_20_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029019">
        <property type="entry name" value="HEX_eukaryotic_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22600:SF58">
        <property type="entry name" value="BETA-HEXOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00728">
        <property type="entry name" value="Glyco_hydro_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14845">
        <property type="entry name" value="Glycohydro_20b2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001093">
        <property type="entry name" value="B-hxosamndse_ab_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00738">
        <property type="entry name" value="GLHYDRLASE20"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55545">
        <property type="entry name" value="beta-N-acetylhexosaminidase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016562084" description="Beta-hexosaminidase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-hexosaminidase eukaryotic type N-terminal" evidence="11">
        <location>
            <begin position="21"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 20 catalytic" evidence="10">
        <location>
            <begin position="192"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="8">
        <location>
            <position position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR001093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001093-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI11244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="584" mass="65568" checksum="995BAB4459E1E4FA" modified="2018-11-07" version="1">MIPLAAFILAAVVVPDTAYALWPAPQKLSMGRDFLFIDQNVSITYNGHSLSNHLDYSPPAGDSFNSEQIVQAAVSRALKAIFKDNFIPWKLRPRNSDFEPDDGGPDKPSVKSIAIFQTQVDRPETFKPHDGQVDESYTLDVSREGLVKVQCKSSTGCLHGLETLAQLFFQHSSGDCWYTPHAPVSIQDKPVYPHRGVHLDVARMWYPLADIKRTIDAMAWSKMNRLHLHVTDSQSWPLEIPALPKLAEKGAYRKGLSYSPSDIAALYEYAIHRGVSIVMEIDMPGHFGVVDLAYENLIVAYNQKPFQWFCAEPPCGALRMNSPEVYDFIEKLFDDLLPRVAKYSSYFHTGGDELNKNDSKLDPGVRSNDPAVIKPLLQKFIDHAHGKVRQAGLTPLVWEEMATEWNQTLGEDVIIQSWLGKGAVEKLVKKGHKVIDSDFNFWYLDCGRGQWLNIENGPAFQQYWPFNDWCGPTKSWRLVYSHDPRAGLSGKEAELVLGGEVAIWSELMDSTNVDSIIWPRASAAGEVLWSGRQDASGRNRSQYDAAPRLAEFRERMVARGVMAMPVQMVFCTQGTPEDCAMTVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LA14</accession>
    <name>A0A367LA14_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_7369</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LA14"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016611509" evidence="2">
        <location>
            <begin position="18"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI11253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="93" mass="9926" checksum="28B20143FF94C515" modified="2018-11-07" version="1" fragment="single">RLLARLSSLLISSLAGALDTLTHIQGTRPEGLGGSRDAGPAVAGPRPPYVIEAERHNNVGGGYAVQRLRPYGPYGPYEGRNVGKFPPKAYTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LA75</accession>
    <name>A0A367LA75_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_7775</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase gamma subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LA75"/>
    <dbReference type="STRING" id="1330021.A0A367LA75"/>
    <dbReference type="OrthoDB" id="286637at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04618">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04641">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF35">
        <property type="entry name" value="LD22662P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0129">CBS domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="123"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="204"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="280"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="354"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI11313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="422" mass="46618" checksum="165AAFD1518186BC" modified="2018-11-07" version="1">MDDKDSTAPPSALPSDNPALPSAEAQPTSREPVGGAGGGGTLVGLPAPDPSTTSHPLQPREQPSSLRIPRFAAPSSYLRFKTGQSMASTSAAPPSPLDKEQRQGLRAIREFLKVRTSYDVLPLSFRLIVLDTDLLIKKSLNILIQNSIVSAPLWDSETSRFAGILTATDYINVIQYYYQFPDEMSKLDQFRLSSLRDIEKAIGAIPIETVSVHPSQPLYEACRRMLKTRARRIPLVDVDDETGRETVISVITQYRILKFIAVNNEHNTVLLKKCVRETNLGTYDNLATVYMHSTVLDAIHMMVDRNISCVPIVDADNRVLNAFEAVDVIPCIKGGAYEELDGSVGDALCRRPDDSPGIYTCCEGDRLDSIFDTIRKSRVHRLIVVDDENKLKGVISLSDILKYVLLSGEEQANQHRATKLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAN3</accession>
    <name>A0A367LAN3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="24">Probable threonine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="7">5.3.4.1</ecNumber>
            <ecNumber evidence="8">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Protein disulfide-isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">Threonyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="31" type="ORF">L249_7290</name>
    </gene>
    <organism evidence="31 32">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="31 32" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="31 32">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="31">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="7"/>
    <dbReference type="EC" id="6.1.1.3" evidence="8"/>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LAN3"/>
    <dbReference type="OrthoDB" id="5423599at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02995">
        <property type="entry name" value="PDI_a_PDI_a'_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02982">
        <property type="entry name" value="PDI_b'_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02981">
        <property type="entry name" value="PDI_b_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01667">
        <property type="entry name" value="TGS_ThrRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21437">
        <property type="entry name" value="zf-HIT_ZNHIT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000139">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000154">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000185">
        <property type="entry name" value="Protein disulfide-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000017">
        <property type="entry name" value="Protein disulfide-isomerase A4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000019">
        <property type="entry name" value="Threonine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000006">
        <property type="entry name" value="Threonine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000005">
        <property type="entry name" value="Threonyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005792">
        <property type="entry name" value="Prot_disulphide_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01130">
        <property type="entry name" value="ER_PDI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF46">
        <property type="entry name" value="THREONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="18 25" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="19" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="20 25" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="32" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="11 27" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="27">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016842552" description="Probable threonine--tRNA ligase, cytoplasmic" evidence="27">
        <location>
            <begin position="23"/>
            <end position="1872"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="29">
        <location>
            <begin position="6"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="29">
        <location>
            <begin position="338"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="30">
        <location>
            <begin position="1133"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="28">
        <location>
            <begin position="1412"/>
            <end position="1693"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="474"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="749"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="866"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="1020"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="1796"/>
            <end position="1819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="1839"/>
            <end position="1872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="488"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="781"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="26">
        <location>
            <begin position="866"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="26">
        <location>
            <begin position="890"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="26">
        <location>
            <begin position="1038"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="1796"/>
            <end position="1817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="26">
        <location>
            <begin position="1848"/>
            <end position="1872"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="25">
        <location>
            <begin position="53"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="25">
        <location>
            <begin position="388"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00031900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00039846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00072369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR605792-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="29">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="30">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="31">
        <source>
            <dbReference type="EMBL" id="RCI11488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1872" mass="209052" checksum="80D1DAD54B770CB2" modified="2018-11-07" version="1">MHHKRLALGLAAVLSGIATADSDVQQLTGKTFKDFITGNKVNLVLAKFYAPWCGHCKALAPEFEVAATSLKEKQIKLVKIDCTEEKDLCEEYGVEGYPTLKVFHGLDKVLPYNGPRKADGIHSYMVKQAMPAVTILAKNTLEEFKTADRVVLIAYISADDKASNETFTSVANSLRDEYLFGGVNDAAVAETEGATFPSVVLYKSFDEGKNVFEEKFQVEALEKFIKTAATPLVGEVGPETYAAYMSAGIPLAYIFAETEEERMKLAEALKPVAKAHKGKVNFATIDAKQFGAHAGNLNLKTDKFPCFAIQDTVNSKKYPFSQEKEVNEENIKAFVTDFVNGKIEPSIKSEPIPEKQEGPVTVVVAKNYEQIVMEKDKDVLLEYYAPWCGHCQALAPKYIELATQYAESEFKDKVVIAKVDATANDVPDDVSGFPTIKLFPAGAKDAPITYSGSRTIEDLITFIKENGQHKAGISVKAEGTDEAAPAASDKDTAEAKKDEAEAKKDKADAKKDKEAEEDHDELEAEISADLTTREGFDSFCRERKVQMVVFPVDQGSVTSSTSNVLLSWRVRVTKLLAAASAIFESKDTTMEDRQPFSAPTRLLGESIALDTVTTLGKSQDEYEKRQKRYFLHGIAVDGAARKNAAQQEAEKTFEFGQQRIFEDLSFCFLFLLFCGERRHSEKLTLREKLPSACVVAAEAELLRRRVWYFSFSRHGNDKATLPTMNNFGVIELAGGKTTTAPGWAYVPDIGPGPGAPPQPANRKRARTGPGSTRLSLGDVSARQEAKTRKEVEALDSDWGRDNTIPLPGRARTIELADLETKMTAPTKHTPNVRKILQSQKTFANHLDDFVAMQALAEANAVQAAQGSGAKSTHAPTSAAATAAAASTKRPSTRRRKVAAKRPTTGSGTARLADEVDQEALLASRVPEVPSEEELQRLMTLPPLSYFEARAVCDDRYPARVFCEVCGYWGRVRCIKCGTRVCALDCLEAHREECVTRYGLSSRESWDWIGVLRRAGIAKPRICRPGQTPPPPWTHKVLASSTSAPSAPSSTAGHLTMSPEQADVSQAADAQGLPSRPAKQPKEKGAKAPKNAGLEVRRRHPFLPTLPDFVQHRLDIFNKIKAKQDAEIASKPREEITISLPNGKQEKGTSWETTPAALAKAISKSLLERTVISRVDGELWDISRPLEKSCKLELIDFEDIEGKKVFWHSSAHILGEAAERRFGCFLCNGPPTEDPPGFYYDMANMEGVPNTHEWCSAVIAEEDKKALETLSNSIIKEKQPFERLEMTKDELLEMFQYSKYKEYFINQRVPDGTRSTVYRCGPLIDLCRGPHVPHTGNIKAFSVLRNSAAYWLGDSKNESVQRIAGISFPDKKQLDEYKTFLAEAAKRNHRKIGQEQKLFFWDEMSPGSTFWLPHGTRIYNALMDLIKGEYRTRGFVEVMSPNMYKADLWKVSGHWNHYEENMFTFEVEKEKFGLKPMNCPGHCKIFAHSDVTYRELPWRMADFGVLHRNEFSGALSGLTRVRRFQQDDAHIFCTVDQIREEIEGAFDFLYAVYGLFGFSFKLKLSTRPEKFIGEISLWDMAEAKLKDALDAFTGRIGAKWEENPGDGAFYGPKIDITVYDALRREHQCGTIQLDFNLPRRFKLRYVAAKDEAPAADDKDLPAGYGRPVMIHRAVLGSFERMIGILTEHFAGKWPFWLSPRQVLVVPVMPAVNDYAQEVQRELHEAGIFSDVDLSSNTFQKKIRTGQLEQYNFIFGGFSSSSSSSSFLLLLLLLLLLGSSPQLDRRLTQMEKVVGAEEAKSRTVNIRNRDDQSTQKHGELVPLQEVQKQLLKLKSERRLENKWTRHGTAEEEEEEEEEEEEEQGEDGEGDRTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAQ5</accession>
    <name>A0A367LAQ5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_7696</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAQ5"/>
    <dbReference type="OrthoDB" id="203796at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37848">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37848:SF1">
        <property type="entry name" value="SUN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI11496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="352" mass="40061" checksum="8CE6AF04D63ACA79" modified="2018-11-07" version="1">MSSHDDFSAIGPVNPLLPRGTEPLVVPFGHDSDATTAYYLDSRLDYDPDFLADHIRRLAVIPPRPSVRLRGTHRQRRQRSGDKSHLSGDDVVVDFDIRIDLTHLLYSDIRRQQSWRALVTAGNFEKVRRGTVFPDRAPGFGGAPCPGAVEEQLDGVPGLERWCHRYCASSSPLRCFSLQRRIVGWDWDLIRRRLEALVRATNYRGHAVVSFPVGNTRADMYNDCRTNRYRLTGWICFVFYATLLFVLSWPWLFFRTRRWETVAAEWYVSRPTSVPGRREYAAGVSEESWYNLWAPAIQRALLERRDGQLDQADLERARGQTVATGPGGSVREGVQTAMGVVNRSFGWGGDEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAX5</accession>
    <name>A0A367LAX5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_7250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M43B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAX5"/>
    <dbReference type="STRING" id="1330021.A0A367LAX5"/>
    <dbReference type="OrthoDB" id="536211at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47466">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47466:SF1">
        <property type="entry name" value="METALLOPROTEASE MEP1 (AFU_ORTHOLOGUE AFUA_1G07730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016685707" evidence="2">
        <location>
            <begin position="19"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI11571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="365" mass="40537" checksum="7EE6C9B7DCB0D12E" modified="2018-11-07" version="1">MLFLNAALLGSLVASTSALSLSRPSRRSLGHGDGAKKAFEPLDIGVHVHIMASPAETQISDHAVENQVRIMNDNFAQIDISFHVESVERVIDASWASGLDDNGMKWENNKGNGTALNLYIVEEFVKWNRTVGTFRSMAHLTKDPYGYRVDGVVLSQLAVPLSPRWDPEGPYEGKQAAKKIAAWFGLPSVMRSSCDSTVDLIGRPAVLDIPAAIRIRPRERKAGGCQVGRNTCPDQPGVDPIHNFVFGSDESCAREFSPGQGERIRQMWSKTRVGRKVFGPDTEWLPVLNTTTAEGKKPFYIDVSDAAASKFCQPDRFGVTAVKDESRCGSFYYCTWMRNHEESRDQPRCLAARADPPFEEDDFFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBL9</accession>
    <name>A0A367LBL9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mannose-1-phosphate guanyltransferase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">GDP-mannose pyrophosphorylase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">GTP-mannose-1-phosphate guanylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Translation initiation factor eIF2B subunit epsilon</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">eIF2B GDP-GTP exchange factor subunit epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_7552</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="10">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBL9"/>
    <dbReference type="STRING" id="1330021.A0A367LBL9"/>
    <dbReference type="OrthoDB" id="424572at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04197">
        <property type="entry name" value="eIF-2B_epsilon_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05787">
        <property type="entry name" value="LbH_eIF2B_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11558">
        <property type="entry name" value="W2_eIF2B_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000066">
        <property type="entry name" value="Translation initiation factor eIF-2B subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035543">
        <property type="entry name" value="eIF-2B_epsilon_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051956">
        <property type="entry name" value="eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056764">
        <property type="entry name" value="LbH_EIF2B3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044123">
        <property type="entry name" value="W2_eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25084">
        <property type="entry name" value="LbH_EIF2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00515">
        <property type="entry name" value="eIF5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="W2" evidence="12">
        <location>
            <begin position="568"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="463"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="470"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI11838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="753" mass="81038" checksum="42663A5FBC495D49" modified="2018-11-07" version="1">MSQKAKSSSKGGKKPAKSGETKSEQLLQAVVLADSFQQRFRPFTLEKPRCLLPLANRPLLDYTLEFLAMNGVAEVFIYCGAHADQIEDYVSHSRWSTASRSNPFSLIQFVRVSDAGSVGDVLRDLDTRSLVDGDFILVHGDLVCNMMLDGALAAHRARREADAANIMTTILRSAGDDIGHRTKTNAITPVFVVDSDSKRILQYEETTPLQRSRYLALDPTVVNDLSSDFEVRSDLIDAHIDICTSEVLVHWSESFDWELPRAHFLHGILKDWELNGKMMYAEVLDEGYAARASDLQMYDAISRDVLACWTAPMIPQNNVAPEEGYQRRANGLVVESGVDIAPDACLSNTVVGRDVTVGPACTISNSVIGRGCRIGAGVVIQDSFIWHDVTIGDEARVKHSILADSVVVGRDCVIPAGCLVSTRVRISPGVALDATVVLSTTSPTGEPVFEDTALLGPETNAAVFDLQGGDGDEDDDDDDDDSIAGEDPSSLQKSLIYSLADVNLSTSSVSTLSSSTNASTTSLSSTANGTVAATMTATTTMTPETTMTSSSLPTSSAGVDIADDGSARQQQSFHDDAVHGLVDALRAEVATDFASAKLEFMGLRLSSNASDKMMRRAVATAFATRAAELLTPQHGSLEPSRAAERALTRHKGAAGFVADVGVAGRSVDFIFALQAALLRLSAETLKMGTLLSALLQQLYGLDVIDEDAILAWWYHDTAVDADHGLAALKERCSKLVEWLENASEEEDDDEEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LC83</accession>
    <name>A0A367LC83_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone deacetylation protein Rxt3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LC83"/>
    <dbReference type="STRING" id="1330021.A0A367LC83"/>
    <dbReference type="OrthoDB" id="3596986at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.20">
        <property type="entry name" value="LCCL-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036609">
        <property type="entry name" value="LCCL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013951">
        <property type="entry name" value="Rxt3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14312:SF1">
        <property type="entry name" value="BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTOR A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14312">
        <property type="entry name" value="CREB/ATF BZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08642">
        <property type="entry name" value="Rxt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69848">
        <property type="entry name" value="LCCL domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="735"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="844"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="412"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="849"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="906"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="932"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="961"/>
            <end position="978"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="978" mass="106180" checksum="51FF5238EEB1D7AA" modified="2018-11-07" version="1">MARRLLGLRSPPPSVLRPLSLPLATCPPASRKQRNVHLVPARWSAPASRDAQPPAGAGAGATAAAAAAASSSQHYPTSAAFAHASPRMHSASSDYQPFRRPQTPDHQRLYDPRASTAPSPRGGAGHYSTTPDLQRYGTPQAAAAAAASSSSYHARHPSTPADATAPSPRGGAGHYSTTPDLQRYGTPQAAAAAAASSSSYHARHPSTPADASMDPARMPRALPPRPMELGRPDDAFARREVEHSPERPAPRPYVSYEDRYRSERDRPPEPPRERAYSGGDSHRQPMPHDMSRRESHPGGPPPYGRPADGRDQQWPRPGTDPNYRAPMDHQREPPASSPYPPPHHPPPHQRSLLAVQDIARKGRISPLPQAVQGAQPQHPGPGAEPGIKSEFGRMFSGIGSGVGAIGAQSHHQQQQQQQQQQQQQPPPPPIAAAAAIAYANLPPGIKREEADGAAVETGGAVKGKGRRRKLKDDESRDDDAAVGGPERPSSGGGRVSKRPRAHHHHQYAHPTPLAAAAREEPWVSRGRSHHHHHHHHAPDAAETPGANKGLKGTTTSPTDKGSVAGSASAPHHHHHHHHHGSRPGQGAQAKQRAQSPAIPPKPKTTVSSKAVVEAVADRPRHHLGDFIYEAGLRPIRLLPRTPTHRGFSSNPKPLPWEVIKGKENCTLTVKVPRAHLSDAAREEITSRAYLWGTDVYTDDSDIVAACIHGGWIRGEWADDVDGILFDDGRKAKRRADEAAESEGLITSPPASGPAPVPANRDLHVNVLILPKLARYAATTRYGISSREFGGQHGVRHSTHDGISYMIKSIRWVENGGQPQARLRGKARRERMRKVMREVTMTFGNGNGAEQQQQQQQEQQQQEQQQQQPQQPQQQEQQQQQLELQQQQQRRRRQQQQQVKDNQAVAPRDDGSGEPWRTREPCDRTTNGEGAGEDGRQRSEGDKENRLGIKDGDVGRPVQESEGLKGRETGGEGEDGGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCX7</accession>
    <name>A0A367LCX7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_0924</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCX7"/>
    <dbReference type="OrthoDB" id="4927827at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI12288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="95" mass="10600" checksum="AC11039BBAC36ACE" modified="2018-11-07" version="1">MPRRLSNYLERGCKDPSRLEDTRDRDAIDTIAQTDQKNLMRYLVGIKALGLTLGSACDPKDLKLRVYADASFANDLYTRCSTASHVVFIGLGPVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDJ4</accession>
    <name>A0A367LDJ4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_0410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDJ4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI12487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="111" mass="12455" checksum="62F590EFC6CBACB8" modified="2018-11-07" version="1">MISIVYLTDITDESIAGPFPPRPINRPSHDGITWSVRLVPIKSNSRKMTTAVNNFFPTTRHPSRPAFLSARTHHIKVNAVSEEKQEVRARNVTRSAAMMMERASGEERGVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEG1</accession>
    <name>A0A367LEG1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_0897</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEG1"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016975410" evidence="2">
        <location>
            <begin position="25"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI12809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="233" mass="25779" checksum="84943081E0FA511B" modified="2018-11-07" version="1">MLPRSTVSFFIFLFGLLFPSLCWAINGPGLAAKFAGGHTLSKSPDHRSWGLPGGNHRNYSPSSNPEAYNRRLSTDHPPAVSQQNRPGASLSNYASGSWRSWTPRRGDASSSSGWEKPGYRSTPSPAERPRRGSLRSTWSSTRMLETIDESPLRSASLDSPSHQQLSSHWNPASHRQQPNLRESPSHSRSSKWTRPISVNFIPAAASGTIIVSRTVEILKVKNFGTGYMFFLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LES6</accession>
    <name>A0A367LES6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA-dihydrouridine(47) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="5">1.3.1.89</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">tRNA-dihydrouridine synthase 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">L249_0249</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28 29">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="21">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs. Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>5,6-dihydrouridine(47) in tRNA + NAD(+) = uridine(47) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53364"/>
            <dbReference type="Rhea" id="RHEA-COMP:13539"/>
            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="22">
            <dbReference type="Rhea" id="RHEA:53366"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>5,6-dihydrouridine(47) in tRNA + NADP(+) = uridine(47) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53360"/>
            <dbReference type="Rhea" id="RHEA-COMP:13539"/>
            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="25">
            <dbReference type="Rhea" id="RHEA:53362"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="23">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="24">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the Dus family. Dus3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.89" evidence="5"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LES6"/>
    <dbReference type="STRING" id="1330021.A0A367LES6"/>
    <dbReference type="OrthoDB" id="259935at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102265">
        <property type="term" value="F:tRNA-dihydrouridine47 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000145">
        <property type="entry name" value="tRNA-dihydrouridine(47) synthase [NAD(P)(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25585">
        <property type="entry name" value="zf-CCCH_DUS3L"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0288">FMN</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="18" id="KW-0520">NAD</keyword>
    <keyword evidence="16" id="KW-0521">NADP</keyword>
    <keyword evidence="19" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="15" id="KW-0862">Zinc</keyword>
    <keyword evidence="14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="27">
        <location>
            <begin position="316"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="DUS-like FMN-binding" evidence="27">
        <location>
            <begin position="564"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="69"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="26">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00031322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00045934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00049513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="RCI12928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="725" mass="81151" checksum="09EE748FEE51AEAA" modified="2018-11-07" version="1">MIDNDEAPAQAQVDGNEPTSEEPAAKRIKTNASAEPQTTETGSRAVFDRQSGLAPVKKEYLIDLSTLKPTTASDAIDDDEAEARGAVAGPDAGGSKDKDKDKKIKKKKGQNTERTFGKFDDEIRLCNSRALYPEFSPRECKFGDRCKMCHDIRKYLADGRRADLQTFDGKCPVFEQHGSCPSGWKCRFVKSHMLEVTRDDGRSELVLRAVSTGTEEQKEGDGEEANLEQDDGRPGVVNVVSLQNKALLNRKRLDFAKADEYITWMNKEAEINSEFHHRRKNQSSEGIQDLRARFVDPPFKPSEKRRLYFGPETPTLAPLTTQGNLPFRRLCVELGCQLTYSEMAMSLPLVQGSKADWTLLRAHESEMKPPRFDPAAGRSFVFDDYDNARDVKFGAQISGNQPWMTTKAADALNRFCPRLRLIDLNCGCPIDMIFKSGGGSALLESQGKMERMVRGMNVMSGPIPITAKIRTGVKGNRPVATQVLGRLAFGAREHRARLGAPGCAAVTLHGRSREQRYTKRADWAYIAECAALVGSYNSQRDAVTDTAAAPDESTLPNAKDGRMYFIGNGDCYSHVDYQDHVEKARVDTVMIGRGALIKPWIFEEIEKGQYLDKSSSQRLAYIERFVRFGLDAWGSDELGIGFTRRFLLEWLSFAHRYLPIGLLEHLPPNLNDRPPAYRGRDELETLMASPNYKDWIKISEMFLGPAQAGFQFQPKHRSNAYEAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEV4</accession>
    <name>A0A367LEV4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcriptional regulator</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEV4"/>
    <dbReference type="STRING" id="1330021.A0A367LEV4"/>
    <dbReference type="OrthoDB" id="552755at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037647">
        <property type="entry name" value="HIRIP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15410">
        <property type="entry name" value="HIRA-INTERACTING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15410:SF2">
        <property type="entry name" value="HIRA-INTERACTING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="389" mass="43472" checksum="DE76D3ED14F0CDEE" modified="2018-11-07" version="1">MPPSAKELERALIDATCHIYKTDPDAISVNSVRRHVEQKFALEADFFASSEWKSRSKTLIKEYVDKLLDGWTPKTQGRLKRPSSEPSSPPIKRQKRASQPKSGKREKSSEPRPKPRTKKNATRPKSETSTTDDDAEPPTSPRLEKENRKTVKDESEDDAINHGDLDHGKEPERPTKSRPDADEEKVQEDGDARDTSTGEEVKPAVDEEEEYSDVIDEVPNPKARRKNGKDAPKPSKPAPKKVSTDDGPEAEIKKLQSQLVKCGIRKLWHNELKQYGTDTRAKVRHLKKMLAEIGMDGRFSEAKAREIKETRELMAEAEAAQQMNQLWGLSSTGRASRSKSKSTKVEESEVVAADGESEDDDDGGGNSFAARRRRAQADLAFLGDDSDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEZ3</accession>
    <name>A0A367LEZ3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DUF726 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_1308</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMCO4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEZ3"/>
    <dbReference type="OrthoDB" id="277931at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007941">
        <property type="entry name" value="DUF726"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920:SF22">
        <property type="entry name" value="DUF726 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_2G12860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05277">
        <property type="entry name" value="DUF726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="266"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="39"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="41"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI12987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="600" mass="64806" checksum="C3171C2600BDE405" modified="2018-11-07" version="1">MSPLCADPRQVVIALDRRQRKTLLQLVQEIISQMISQVEVATEKPGRRESIEKIEDGDGEDEARKPSAEKPMTAKDAATIQEAAVEKLGQWRDELVPKVREIVQVEDTPAIETERQARKGKQEKEDDSQDTETDDLAQLRCLYCPIPTPLTSLPIQDRREALTSILLLLLSTGKYPAHSRILILHLASALNIPPPSSTNKKAKSQTQQGMSADAEAAKRKEDNKLSRYWKVGLASVAGAAVIGVTGGLAAPLVAGALSSIMGGVGLGGVASFLAIFWANGALVGALFGAYGAKMTGEMMDSYAKEVEDFRFIPLNNAPQSPHKLRLTIGINGWLTSPSDIAKPWQVLGPESEAFALRYEMKTLLSLGTALNDLVQSLAWKTLKRELVKRTALATVLAALWPVQVLAMASTSIDNPFQRARHRSRKAGRLLADALVNRVQGERPVSLVGYSLGAAAIHACLQELADRRAFGIVDSVVLIGAPAPAATQHWRALRPVVAGTIFNVFSENDLVLGLVYRLHALDYGVAGLQPITDVPALRNIDLSAAITGHLRYPLLTADILARCGFSVCPVDDAAQEHVDSSDTLAPDEQPAQVIEAQGETH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LF22</accession>
    <name>A0A367LF22_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0978</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LF22"/>
    <dbReference type="OrthoDB" id="5209158at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="183" mass="20246" checksum="754DD6E9255A5FE3" modified="2018-11-07" version="1">MPKPAPSRRSTNQTLTISQTRTMASTRSSSVSTTKSHHQRRETGFPEPLDEDRNTTLPHPDADRSPGACISQDEVAIDRALKRHRLSFLHKHRKNNQTSVRHQPDVLDSSLSLSATVPDAGPKNTKVQVPTRSTSSLHLSREGGGSERSPRDGGGDDDTPPTSPDVIELSRTRSLFRKLRKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LF48</accession>
    <name>A0A367LF48_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial glyco protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LF48"/>
    <dbReference type="STRING" id="1330021.A0A367LF48"/>
    <dbReference type="OrthoDB" id="278212at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.280.10">
        <property type="entry name" value="Mitochondrial glycoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003428">
        <property type="entry name" value="MAM33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036561">
        <property type="entry name" value="MAM33_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826">
        <property type="entry name" value="COMPLEMENT COMPONENT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10826:SF1">
        <property type="entry name" value="COMPLEMENT COMPONENT 1 Q SUBCOMPONENT-BINDING PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02330">
        <property type="entry name" value="MAM33"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54529">
        <property type="entry name" value="Mitochondrial glycoprotein MAM33-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="347" mass="37370" checksum="3CEF45D9F26A1A5F" modified="2018-11-07" version="1">MLSLRLAARCAPRMLRHSATTKQTLRNGGITIAGFVSGPSAACTTASASATKSFRAGFSSSRTLEATKKDAAAAAAAPSGEVDEELVFKIDSEIRIEEDLKDDAQLPASIGDFLDNTPFTLEEKPGVEAVKLVRSYGEEKITVSFSISDLDTSFDPYSNDDALEDDLEQGGSKHHDPSSSSSPAQSSTLTSRSASTTQNSRSNQAAENQEEEADMMEDPTEEDEMSEDAPAPITMTIVIEKPAKAPGALSISASARDGAIEVEAISYLPDAKLATSDTPDVVHKRIDLYSGPPFGSLDEDLQLLIERYLDERGINQAMAVFVADYVDAKEQKEYVRWLENIRGFIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFA3</accession>
    <name>A0A367LFA3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_0220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFA3"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI13100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="177" mass="20320" checksum="4587A00A975B8749" modified="2018-11-07" version="1">MPQGASAFPLGPRMATMARHITKPSLLFLWFATPEQESRWFRENEAVEKLPLPILYHHPINIAIKPPALYTPRQDPCPSLIPDYDKEKLNKGLLLARFRFLTNSHHPSIKFLFKNVIAWNPYVPEAPDETTIHQPRPCFDHVFFRQLGVRVLQHVENYACFAILLPRCEGIIGSGTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFD0</accession>
    <name>A0A367LFD0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GTP cyclohydrolase II</fullName>
            <ecNumber evidence="3">3.5.4.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_1136</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 2 phosphate + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.25" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFD0"/>
    <dbReference type="STRING" id="1330021.A0A367LFD0"/>
    <dbReference type="OrthoDB" id="5569761at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="entry name" value="GTP cyclohydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055781">
        <property type="entry name" value="DUF7357"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001591">
        <property type="entry name" value="PRK00393.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327">
        <property type="entry name" value="GTP CYCLOHYDROLASE II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327:SF29">
        <property type="entry name" value="GTP CYCLOHYDROLASE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24054">
        <property type="entry name" value="DUF7357"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="RibA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="GTP cyclohydrolase II" evidence="10">
        <location>
            <begin position="190"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7357" evidence="11">
        <location>
            <begin position="450"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="121"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="618"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="752"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1026"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1080"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="754"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="849"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="911"/>
            <end position="928"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI13138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1276" mass="139683" checksum="EFFB7BF79D9F97FE" modified="2018-11-07" version="1">MSLQTSAICTGDRPSKYTFKAGAISHLSKPFTVTAARSSLPARENFHPFAGETPASSGPEHQPLFDIRGRLSDRPHAIRLTKPILPPIMSPDVDAPCRLPSFYSPPTKPEAATGQPIDLLSLPESSTVPRPSPQPSPPPSLLSPAVTPRAQTPSASAPRGVPVDSSIPSGGCGTKRPRLLETLPEVQCIVRARIPTVAGTEMFLHLYTNSVDSKEHLAIVFGNHIRSQSLDAPREGETEMDRMVRGAYTGRLYPGRTASHASAATADESVVTPSKTPPLVRIHSECYTGETAWSARCDCGEQLDEAARLMGLPESASGGIIIYLRQEGRGIGLSEKLKAYNLQDLGSDTVEANLLLRHPADARSYGLATAMLLDLGQTDIRLLTNNPDKVRAVEGPNREIVVRERVPMVPLSWKGQGGFRSDEVEGYLKTKVGKAKSRFEIVNMPLQEPLRLRLSVHRYGVPDVKLVWPCERSSDFTIFKLLDQVNQVIPLETSEWGLEDYAVELADSSGGSYECLHFQQVSEILKNDDEVIIRCLQGDDLKRRRLTGRHQISADGRHLVDGIVFGRPWLRTPRDRPALELPPRKRARFAEDYYDGNDDIDKYAYGHDERQPRLLEEDPDAFDDDESFHDSGPDQDGDESSGDDMDDEGDDEKDLAADRKFLLQANQTLDHVVLRGATSNTVMNGLDLNSLDGIVALRAAFPLTPVTAIEAELLRNNKDVEKAYNSLNRSNDSALSFDKVKERCVMRGIPIADGSASKSNTGSASSVQSAERPLIEVVESVEDESSGSAVDEKESSDSDTDDEVTSLPQDTSSDSSESDTDDQTAGAAQESSSDDGEAGSDCDGRESLSDSSGTSDSDSSLSDSSDDGAPVGQLFMAHSQQAKTGSGSQGGHSSTVKGDKPAPTTENQAGHKSRPLTKTQKRNARRRMQTANRQAERERSVHVLLENHKQQLLRSIAPPRSAEEDAASEALLEVDAGEIAPDKRRSRVDNGAGRRLLFGALGLKAPKTKAEEDEIKQILMKGVRPLQNPRLEQSEAADESTPTAPDPADDSWRQKLTYCAEECCHEDVHLSSPPFPFKQRWDPQQRWVPQQGTEKAGSKRKRKHAEDFYGDCDSGLCVDEEDANRTRSEATGGDSFPDTADEDLVALPADLNILPVLRAEAVREGMIITWRQMVMSKATRWQPQIAQRTGRVLSGTDEAEVHVQLAVRDREDRKKTYDAKTGQRVYDKFEAPDLDGEDDVDGDDDGVRMLSWEELIDPRILGDGEEAETMVAATVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFI0</accession>
    <name>A0A367LFI0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_0236</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFI0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI13180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="86" mass="9905" checksum="06841B0D8F1DA83D" modified="2018-11-07" version="1" fragment="single">CYAAIRPQLATNLRIPIERISPRRIRAYTLLFHSLRIPPLARRLLGLGLTSRLPFHPSSGDLLRPAYNGFRLYRLSYPQPSHDDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFS1</accession>
    <name>A0A367LFS1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_0118</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFS1"/>
    <dbReference type="STRING" id="1330021.A0A367LFS1"/>
    <dbReference type="OrthoDB" id="5344325at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF84">
        <property type="entry name" value="FUNGAL SPECIFIC TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="14"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="530"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="599"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="556"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="609"/>
            <end position="625"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI13273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="732" mass="82257" checksum="8562A34471F46E51" modified="2018-11-07" version="1">MGEIPPDNGHGRTACTECQRRKQKCNRVWPCNHCQKRKVAAKCRFGSSIPVSTRTEAGRKRELSHDDDLTESSDTSPWDDCESGFGALGYTASHLFSSLATPNRRLRPPPQQFYVDVASCPQLERVLHVLPPRPYTDSLVQNFLNSVNYHYYIIYPPSFLDEYRQWWASRSDNQPLGLQWTCLLLMVCACSAQYTDVDLQRQLEQDLGESIQRLTESYHNAARELQSVIPVGNNHLFNVQSLLHSCYWYKSEARFVECWHVLSVAIREAQELGIHQEPVVGHMSEFDREMRRRVWCILDTWDWQISALLSRPMIIDRTDCDVGLPSLKLEGYSPSPLLHMKLRSELITELAINFKVPKNVVSSVDVFKYQAIIEAWMARLPPVYALDGADESADAQRPWIVLHRHYLHTMAYSMILDPIRAYLARPVAAASHPDELRIRSDGIDYSLRLMDALYGFFDHVYPRDAKFHFVLFCIFDTAAVLCSALMHDGDGTIPRRLDILAAVDGAVDMLRRLANVTKTARTSYDILSRVSQRVTRSPGHTPRTVDNSRRRKKTTRTAPNTTPPSAASSSMPMYGDAVAAASSSSSYLSSYGNTASPPMMALPAPVQPPTSTTTCQQPPPTTNTSTLYAETATYHHQPTTTTNDPPFTVLVPSSTPIDPNNVLMTDYHHPSSAPSSAPAPAPPPGPYLTMTPPMEESFPHLEFGNITQQQLGDLATLWNYESLNLDFIDSHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGF5</accession>
    <name>A0A367LGF5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Wings apart-like protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_5523</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WAPL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGF5"/>
    <dbReference type="STRING" id="1330021.A0A367LGF5"/>
    <dbReference type="OrthoDB" id="78088at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039874">
        <property type="entry name" value="WAPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022771">
        <property type="entry name" value="WAPL_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22100">
        <property type="entry name" value="WINGS APART-LIKE PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22100:SF13">
        <property type="entry name" value="WINGS APART-LIKE PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07814">
        <property type="entry name" value="WAPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Wings apart-like protein C-terminal" evidence="3">
        <location>
            <begin position="289"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="184"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="22"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="196"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="720"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI13489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="720" mass="79293" checksum="39F0E4F3A04EC58E" modified="2018-11-07" version="1" fragment="single">MASRPAESAGPRKLRTYGGLSRSRTSTPSKIRQSRTPILSTAAKLAQSSNACLSRGKSVESPGPDNTNSPPILERSSTETSANIHGVGRKRKRPILAMLDERPDYELGDFLERDSKSADLTSRKPSTGSSLVERDYSMEIRRAVAENTSAAGGTAMEDDFKISIPRRRRLIDALTTPECTRANEIGRSAYNESPEASEREADSAERIHAVPDARSGTGNRRSTPISRKVRLTYSQSRTSGESQALEASSPLPAVSMDDSVLPDTQMRSSPIKDQDTYNIFDDPDPQPAIRSVHELRRSGAINRHADEMDDLLIRVGKPGTGSLATRRTALCELAQRLPRDGFAEQFRDHNCRDKVAIDIGEEDDVVCGFALAAALVIFLKSNSAPHLVRQLTRQGLGRFLGRLLRVDDDIDLYTARRHTKLSRMLAASLHEVKHILVEMSIWHGHAPLQLSPRTLSLRLLETISRCSEGQLLQQVANDLGRDLAIVAAGMRTSEILDYALTVFALEVLSGSGISMVSDKAEFSKLHLPRSIFSFLRAALRNWPSERHELGSAVMKLAINTTNTEDGAAAFKVADLSLLADRIGRGFDNVKQAIDCGVLENSVYDDLLLMLGVMINVMEHSHRARTSVDKTALDKIAKLWEDNQPTISEANLVDKSKLSVAVNYLAVLLGYLCLTTRGRARVNTQVGSLVISIRQFVDMCRAVDSRTKELESLATELYRQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGM4</accession>
    <name>A0A367LGM4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="26">Aspartate kinase FUB3</fullName>
            <ecNumber evidence="8">2.7.2.4</ecNumber>
            <ecNumber evidence="7">3.2.1.21</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="27">Beta-D-glucoside glucohydrolase cel3A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="25">Beta-glucosidase cel3A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="30">Cellobiase cel3A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="29">Fusaric acid biosynthesis protein 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="28">Gentiobiase cel3A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="33" type="ORF">L249_5478</name>
    </gene>
    <organism evidence="33 34">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="33 34" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="33 34">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>L-aspartate + ATP = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="23">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the aspartokinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="33">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="8"/>
    <dbReference type="EC" id="3.2.1.21" evidence="7"/>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LGM4"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071266">
        <property type="term" value="P:'de novo' L-methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009090">
        <property type="term" value="P:homoserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009088">
        <property type="term" value="P:threonine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2130.10:FF:000001">
        <property type="entry name" value="Bifunctional aspartokinase/homoserine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000023">
        <property type="entry name" value="Probable aspartokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2130.10">
        <property type="entry name" value="VC0802-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054352">
        <property type="entry name" value="ACT_Aspartokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF5">
        <property type="entry name" value="BETA-GLUCOSIDASE M-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22468">
        <property type="entry name" value="ACT_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="20" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="18" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="19" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="21" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0418">Kinase</keyword>
    <keyword evidence="17" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="34" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0964">Secreted</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="32">
        <location>
            <begin position="445"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="31">
        <location>
            <begin position="485"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="31">
        <location>
            <begin position="494"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00070030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00073087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00078013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00083231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00083304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00083611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="EMBL" id="RCI13561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1561" mass="167191" checksum="44FFD40EDAC725AC" modified="2018-11-07" version="1">MGSAIRGNSSPRGWIVQKFGGTSVGKFPDRIAQDIVKSTLSHNRLVVVCSARSTGKKAEGTTSRLLGVYNKLRNVGAAYASTYDDDPEALTEQAKSIIADICDDHVLAAEQYVRDPGLRATLSRKIGDECQELIEYVFAAKRFNLEINSRSKDRVISFGEKLACLFMTALLQDVGVDAEYVDLSDTLHCGPSAQLDAGYFKAVTAAFLRKLDACGSRVPVVTGFFGNVPGSLVDGDIGRGYTDLCASLCAVGLGAEELQIWKEVDGIFTADPSKVPTARLLPSITPSEAAELTFYGSEVIHHLTMDQVIRAQPPIPIRIKNVKNPRGNGTIVIPDPVLSAGNQLHLHRPPAKAPKRPTAVTIKDHISVINVHSNKRSISHGFFARIFSILDQHSISVDLISTSEVHVSMAIYSGSTQMDAFAKARQSLAECGEVSVLSDMSILSLVGADMKNMIGVAGRMFSTLGEHNINLEMISQGASEINISLPGTGSRAPGVKEEARGRDRTGKTMSTLHLQPVDNNIRGRLALVTGSTGGIGAACARALAAEGCDVALHYHSSHKAEALAAELLGRHPGQVFVTARADLSSREETRTLVSSVLQQKGVRQKAVSILVANAGSGRRIRDVADVAEQDWDLMLEVNSRSHGRRIRDVADVAEQDWDLMLEVNSRSQFVVTKACVEGMRAQSWGRVILVGSIASRGGGINGCHYAASKGALTSMGLNLATVLAPEGITVNIVQPAMIGATGMMPTPKSSSWERTDDMEELRQRDAGLAIAASVPVRRLGAPEEVAAVVCMFAKTGINNVATIDIITISPPTTPPPYPPPQLPHLRLPPPDWTLASSLASKLVRQMTTEEKANITRGFAVTTNVCAGNSGSVPRLGWPGLCLHDAANGVRATDMVNAYPAALHVGASWDRALTHRRALFMGREFRGKGVNVVLGPNAGPLGRTPLGGRAWEAFSIDPYLSGQLISETITGFRRAGVIASLKHLIANEQETFRRSYAGVEAVSSNVDDRTLHEYYLWPFVDGVRAGAGSVMCGYNRLNGTYACQHSQLLNRVLKADMAFSGFVLLDWNAQHDLDSVDAGLDMVMPLAGAWGDNLTSAVLDGTISEARLDDMATRIVSAWYLAGQDAADFPPPGIGMKNLTEPHPAVDVREPGSRPVLLAGAEAGHVLVKNSDGALPLTPRPAMLSVFGYDAAGPPSKNVDAVFQLGYMSSPAMAQAVLGSDQHFDQAARAGTIVGGGRAGANAPPYISDPLSAIQQRAAADGTWVNWDVGSTEPEVNGASEACLVFINAMATEAWDREGLRDEVSDGLVRHVAAHCANTIVVVHAAGPRLVEGWIDHVNVTAAIVAHLPGQDSGTALVRLLYGDANFSGRLPYTLARDEADYPVYAPCGRGDNSTTDPQCDFTEGVYLDYRAFDAQRLAPRFEFGFGLSYTSFSYSALKSTIRLETDDDDDDDDDDNRERMWEEAAVVSACVANVGPVAGAEVAQLYVGIPGGPPRQLRGFEKVRLRAGEEAEVRFTLTRRDLSAWDVVRQRWALKKGVYPLFVGASSRDIRLKGLLAVGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHE0</accession>
    <name>A0A367LHE0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Folliculin-interacting protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_8042</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHE0"/>
    <dbReference type="STRING" id="1330021.A0A367LHE0"/>
    <dbReference type="OrthoDB" id="5428015at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028084">
        <property type="entry name" value="FNIP_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21634">
        <property type="entry name" value="RE13835P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21634:SF9">
        <property type="entry name" value="RE13835P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14636">
        <property type="entry name" value="FNIP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Folliculin-interacting protein N-terminal" evidence="2">
        <location>
            <begin position="88"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="630"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="867"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1003"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1056"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="630"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="688"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="727"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="742"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1011"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1060"/>
            <end position="1076"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI13807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1201" mass="128042" checksum="0090CDDEC5859E4C" modified="2018-11-07" version="1">MLGRLLHLGSGGVVAPPAQVGGNGAASRPILSLESVQEDIHTRNLLFPDAQALHQHRNDQVFPLSTAPATPWAAAFDYSEDVELDVRDVRVIVLQDALGPANASLLFDSHPSPDSVVDRSPARRVAPTSTSQRGPPESPQHRQGAFDRKSQSYTETDAQRAAREYRDELATFSSCIFGNSELMAYKGTSTKVHVVPTDPRPADHPSASSSIIGDGRSSIGRSSARSSKLSQSFSSQTVSPIGPSLPPAAGRPADKKKVLITRLFPVSLSADDVEPTPNRFSDDNGAFPFPASADDAGTSNKKKLQPKQRRTPMYAVVLVIQLPRSSSRLSSAAAYKSSIFRDCGSCNDPDLFFSSSYSSNNNKASWGIPSYGDVTDSSYSIDMEDRIDSLTQHWDIIMRTLTHLQSLVASSLHTMLRQADMASPGPASSPNAVSRTSSMTDRRGGPEGPRAKPPKSTTKLVSLMPNCLADDAAVASEVMLARTRVVTGLSAARVVTGQGRWGIWRDEAIWTSKWATATDRGPFFCNLLTGFLATHTDWLQALGGRKRVARQHRTEEDMSLPARTIIVSDDKMAARRIVFLLSAFLPASQQLVATARTHRPSTSTSMGAYSNSPPPTFVVPMLREESLRRKINRRTGGLRRASHSRAASQSARNSNQLHHQRRASDAASIRTTNLPIPGQDLVSRKSSAATTTTAVTETTTPYFSSAQLQRDGHRRRRPGSSGSVAADDLKRSLKRGESSCGSGSGGGGGGGGGTRPPSQSGLRWGNLVSGLWGHPRRRDSMDDDYCHSPGAEFRSPVKTTFGRQDRLFEMVREASSLEEAVVGSGSGSGYAAAASATAAPRRDASSLEEAVVGSGSGSGYAAAASATAAPRRDVPFGEGRGSFAQPAAARTPDPSGAFESPVKTSINVEDGVIDVDVPFPDYIASFESAISSPSSSGYLSTPGLLGGGLDSFEQSSARLSSLDGGDMPLNAAGWLNRFHPDFALQALPPQDGLLEKVKASLRAEPTPGPMNGNGGGGGGGGGGGETTERWVDVSSVIIADTTSNSITRHVYRRLIKPRPSSESNNNNNNNNNSSTNLAPPSTPSIAPYECRLEEDWTEEDISSSDAALKDAIERVVYLSPPDVTTSKASDMTSETTLATNGIAPPLDVPRVQCKTVILSALEDMIRDAVDHRDLEGELRGRRRTNVLRDAVRQWVGSLDSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHR7</accession>
    <name>A0A367LHR7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8281</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHR7"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016595994" description="Secreted protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="16107" checksum="68566D3F531A8C14" modified="2018-11-07" version="1">MSLALALAVSVTWLSLSLVRVRQNRQPPSDACSSARLAAAVPGQKLPLPTGRLVVVEIPCGSPFVVIAFYLFPFVLPRVAISLPSLCVLCKHAAKSRIVVFVFLWGCEATVIPRATPVSSVTLARRHLGRGEGNLEHAAQASTPLSSIVSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHX1</accession>
    <name>A0A367LHX1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_8132</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI14010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHX1"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="35" mass="3678" checksum="1666C1B9C3553F3B" modified="2018-11-07" version="1">MPFLPLLCDVRRPRAGYGRPGVTVSGAPAKLLPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJM2</accession>
    <name>A0A367LJM2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_6975</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the trehalose phosphatase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJM2"/>
    <dbReference type="STRING" id="1330021.A0A367LJM2"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1020:FF:000001">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000036">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase subunit Tps2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1020">
        <property type="entry name" value="Trehalose-6-phosphate phosphatase related protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00685">
        <property type="entry name" value="T6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF15">
        <property type="entry name" value="TREHALOSE SYNTHASE COMPLEX REGULATORY SUBUNIT TPS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="18"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI14628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="905" mass="100333" checksum="AE4FE68383813251" modified="2018-11-07" version="1">MTIFICSLFLPKTVQFNLPGTPPRRSRDGARRRARSAAHAASRPTTTTTTTAITTTAVVEDAPPPSLFSPRPDLTPPHTPVDDGPGSPNPFANEDGIGVPLSSPVAAADDDVVPSWGVRLDQPLSRAASPPPAGLVRKARELGRRGICQPTASARSDSHDRVFSSAPWRVVDADQGNGGLRNAVRAAARDGRLAADYAWVGTLGMPTDALQDSDQQPVMERVLADEHRMIAAFAPIETLTATTILWPVFHYQIPDNPKSKAYEDHSWKYYVNVNRRFADTVVRHWRPGDVVWVHDYHLLLVPGMLRRALPEARIGFFLHVAFPSSEVFRCLAVRRELLEGVLGANLVGFQIHEYARHFLQTCSRLLAVEATPEGLQLEDRFVDVVSMAIGIDPISLAAHRASQDVARWLRILRDRYRGKRLIVARDKLDHVRGVRQKLLTYELFLHRNPQWRGRTVLIQVALSSGDNTSDLDASVSDIVTRVNSAWANLAYQPVVYLKQDIDYAQYLALLTIADVLMITSQREGMNLTSHEYVACQDGRHGSLILSEFTGTASLFAGNELSVNPWDHRQCADAILQALEMGDDERRRRWERLHASVTRHTGAAWVGEMLTRLDRAYDEQHRRGALGGGGNLPMHDVTERYRRATRRRLLMLDYEGTLVSWGPVDRIIPVSPQRTLDVLNELLLDERNVVFVMSGRQPEELDIVFRQVPGLGLIAENGCFIRGGADAAWVELSDSGRIQDWKRAVKPIMRYYLERTPGAAMEERHCSLLFHYGGADDHEAASRQASDCANHINDACEAQHVHAVVVGRESIVVEPVDHDKSTAAQHVLDGLVHGGGGVDVDFLMVAGDGREDEKVFRWANQLQERGAVRDVVTVSLGNRCSTEAGATLTQGVSGLLSRLRQLASLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJP7</accession>
    <name>A0A367LJP7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_6955</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJP7"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="102" mass="11048" checksum="C0F2C3F26A976138" modified="2018-11-07" version="1">MLIRRLIILLKKARLAYPVLKRPCPSVTYGGLGPAVAGPASQCLALPPNYSPQPASYVVVPFLPLLCNVRRPRAGRSRPGVTVFSAPAKLGFARILYYAMRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJU5</accession>
    <name>A0A367LJU5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">beta-ketoacyl-[acyl-carrier-protein] synthase I</fullName>
            <ecNumber evidence="2">2.3.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_6453</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.41" evidence="2"/>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJU5"/>
    <dbReference type="STRING" id="1330021.A0A367LJU5"/>
    <dbReference type="OrthoDB" id="5334845at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00834">
        <property type="entry name" value="KAS_I_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000009">
        <property type="entry name" value="3-oxoacyl-[acyl-carrier-protein] synthase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017568">
        <property type="entry name" value="3-oxoacyl-ACP_synth-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000794">
        <property type="entry name" value="Beta-ketoacyl_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021150">
        <property type="entry name" value="Ubiq_cyt_c_chap"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03150">
        <property type="entry name" value="fabF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005589">
        <property type="entry name" value="PRK07314.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712:SF336">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11712">
        <property type="entry name" value="POLYKETIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03981">
        <property type="entry name" value="Ubiq_cyt_C_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="11">
        <location>
            <begin position="1"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="723"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="728"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="739"/>
            <end position="751"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI14713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="769" mass="83162" checksum="D6C9D05E06CB3653" modified="2018-11-07" version="1">MRRVVVTGLGAVTPLGVGIQRTWSRLLAGDTGISSVAMREPKAQWHDLASTVAGVVPRGEKQGQWRASDWLGASDQRRMSTFAQYAVAACDMALEDARWRGPLRPEQKDATGVCVGSGIGNLDELYDSSRALDVGGHRSLSPLFVPKILINMAAGHISLRHGFRGPNHSATTACTTGAHSIGDASRFIAFGDADVMIAGGAEACIHPLAFAGFGRTRSLSTSYNDDPGRSCRPFDADRDGFVISEGAAVCVLEELEHATSRGARIYAELRGYGSSGDAHHMTAPRRDGAGAYLAMRRALSNAKRRPADVGYINAHATGTRVGDAAEAAAIRSLMLGPEGVSVESQVTVSSTKAALGHLLGGAGAVEALIAVLAVHEGIVPPTLNLLKPDVGAAFNFVPLKAQERRVDVAVSNSFGFGGTNSSLTIVTPRVRLLTIASKASNSFRKTPFIPPLHTILSRLRWQLQSLALVATRASTTPTRPRRSLAMQTTRRLSGTGAARGLLGGYAKAYQVIGAAERIFKACSAPADYAISEDDRRNDGVEKLEDGEELGKAVVPNTVWHKTFKLPPSFSTWSHVTMLHLYLVNARVRCFDHDVYRNWQQQLVDQFFFECEKKMHLDHNLTSSTLRQRYLKDVFVQWRGLLLAYDEGLIKGDAILASAVWRNLFKGSPGVDPRALMAIVGWMRSSLVALEALSDQSFTSQVTEILARPVDVFLAYLGEPTEKRPPDVAKGSKSSSASSVRHTNSHNDAQTTRHIRQEQKRQSVKGRSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJW9</accession>
    <name>A0A367LJW9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7087</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJW9"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="136" mass="15239" checksum="B756F0332DD33DCF" modified="2018-11-07" version="1" fragment="single">RPIDSLQRSSQRSARCTYSGHSTRLISAQGSRHIDRRAVLIAVIALDQSSQRDRHSDRRAVPIAVIAPDLDSRTKVRSSVHYQLQLHHFFNTITSPAFNSSSILIKPLSRDSSSSSLSRDPHLDYSSSFPLPQITF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LK74</accession>
    <name>A0A367LK74_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LK74"/>
    <dbReference type="STRING" id="1330021.A0A367LK74"/>
    <dbReference type="OrthoDB" id="417697at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="234"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="288" mass="32641" checksum="343559CF0E235740" modified="2018-11-07" version="1">MSHDDYVLGRGLPDSTRLDAQHLLWAMHLSYVLHPDIPIREDMRIADVGCGSAGMTSIWLLDISRTLPRSTHLHGYDISDSLFPPRSSWPENLSLGLLDSREDPPESLVGQYDVVHLRMWSSNMRSGAKTVECLIRSVTRMLKPGGYIQWEEADLKRQVVQPESSTEYGEELIDVLQAFGIDYSRTADLGSKISWTKTLSASLQRENLSIIKEKQDVFQKFTTQLCTKTYLLAMKEILEGIKQTRNEKETAEQLAMRGEEALARLTSEYYKGLIYNWGPVSILGQLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKA0</accession>
    <name>A0A367LKA0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_6512</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat MET30/SCONB/SCON-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKA0"/>
    <dbReference type="STRING" id="1330021.A0A367LKA0"/>
    <dbReference type="OrthoDB" id="5580488at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd22147">
        <property type="entry name" value="F-box_SpPof1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.50:FF:000016">
        <property type="entry name" value="E3 ubiquitin ligase complex SCF subunit sconB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000715">
        <property type="entry name" value="F-box protein MET30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051075">
        <property type="entry name" value="SCF_subunit_WD-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19872">
        <property type="entry name" value="UBIQUITIN LIGASE SPECIFICITY FACTOR/HREP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19872:SF9">
        <property type="entry name" value="UBIQUITIN-BINDING SDF UBIQUITIN LIGASE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="8">
        <location>
            <begin position="164"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="320"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="360"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="439"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="552"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="617"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="239"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="503"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="633"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI14851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="660" mass="73820" checksum="18EF7BB0487B185C" modified="2018-11-07" version="1">MANQYDASLTAQPSRESCDRRRHQEDDKTRIVKMSSHLVGKAVSPFLKEHIPGIYAPIAKAVLDDADSSVDAATRAKDPNTRYCYRHRPDSKCRRAADETKMGFIQRELNSLPVADQEAITHVWSLFSAAPAKHRELMLQGIITQCCFPQLSTVSREVQEQLKIDFLTALPVELSYKILSHLDTVSLCKAAQVSRRWRNLADDDVVWHRMCEQHIDRKCTKCGWGLPLLEKKKLKAWSQHQTAHRRDDGSDNDTDAESASRKRRLGAANDEDPSKRQRLVLSPRPQLDAERRLRPWKDVYRDRYKVGFNWKTGRCAVKTFKGHENGVTCLQFDDNVLATGSYDATIKIWNLETGEVIRTLHGHASTVRTLQFDESKLISGSFDKTIKIWNWQTGECLSTLQCHSDGVLSVHYDGCTLASGSIDKTVKIFSFDTKQTFSLRGHTDWVNHVRIDSPSRTVFSASDDMSIKLWDLDTKQCIRTYRGHVGQVQQVLLMPSDFEPDALTSDDKADAASTNSSRDGTPTPLVAEGGPTATEWLGSGFAADPTRPEPPRYMLTGGLDNTVRLWEVATGKCIRSMFGHVEGIWGLVGDTLRVVTGANDSVTKIWEPRSGKCDRSFTGHAGPVTCVGLSDSRMASGSEDGEVRLYSFEGEPTEERGTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKB0</accession>
    <name>A0A367LKB0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_6726</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKB0"/>
    <dbReference type="OrthoDB" id="5345571at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057082">
        <property type="entry name" value="PH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057081">
        <property type="entry name" value="PH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23076">
        <property type="entry name" value="PH_FT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23074">
        <property type="entry name" value="PH_FT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="240"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="357"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI14861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="472" mass="54355" checksum="B6C7DEEE5F4EC83F" modified="2018-11-07" version="1">MDQASFFDLQLLQGCCLEAERCDIVAFKLEGLRYALNESNFHLTAVIDEIRAGSRILREVADMSQVHRSRVPLILDPLNVVLPCLSRSLRDVNAHRDDRSRSKINRWRHMYHSMTNETGGVPLSSRFMVYNQYLSSARDLLISLSSLNSFRSPIFDLNVFEKLRHQIMRFREARSIPPPPTQVGQLITCNSFALHGVDPTIHWAERIFSLPLPSRTALRSQQPSTSLGHHLTWDQLEIPLHSKMLFRRSFNDDQISLTAFVNGRDQSPYLLLRTLVCGTPWFAVRGAHELCIDRDGSSLRLKRWSRSEGRSKTWVVLYFLTWEELVLMHSTFVSLKARNNLTIRLSPEECSLGGESKLFQACILDDEFRHSLIVYRDRASGAHRLHAAVWDGELRHCPSASSTWLTRVSPHRVRLADLHLYVFCRQYRPQNQRRGSGGAFEIRFVADEAARRFEQVFWSPPPTPEDSSDRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKH4</accession>
    <name>A0A367LKH4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7108</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKH4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="119" mass="13758" checksum="A8EF5D5D3F227A6E" modified="2018-11-07" version="1">MLIILPSRYFSRYFKVPTYSTLTYLYKIGDLEEDLYVPYPALPEPESLAKEYFWSVGKKGPNEVICGAKSKEEGGEKEVEMDKELTNQEEELEAGEVFVLRRYFSRYFKRCAQGGVGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKW9</accession>
    <name>A0A367LKW9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6808</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKW9"/>
    <dbReference type="STRING" id="1330021.A0A367LKW9"/>
    <dbReference type="OrthoDB" id="3928002at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38049:SF1">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38049">
        <property type="entry name" value="RICIN B LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016645782" evidence="1">
        <location>
            <begin position="21"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="211" mass="23617" checksum="5422343273952F51" modified="2018-11-07" version="1">MVLGLLAITAIPTITGVGQAVSAQKKQNAAAKEQAKFYLTASVPGFREIGVCVLSDGKLLVELVENQEEECAQEPQPQLQSTKGHKFCGYYFTYPSEEQHLGLVSTIADDPPMLNWIYVNRETREVEHGGRKQTLGHVIGPWGWSRDESFLTLQGDDEGFVVREGEGGYWAVYWEPDSVESERTTHHCMPVKLRRRPLLGVNSRYVRGHEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LL46</accession>
    <name>A0A367LL46_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_6792</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LL46"/>
    <dbReference type="OrthoDB" id="4207724at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI15148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="454" mass="47925" checksum="1E8B704124E3F8DE" modified="2018-11-07" version="1">MAADASMNYLYTFGGYATLIGVGYALYRVSTHKANRRAAPSATRGGKAPLHQEPRKEDRKKKQRMENFASETQQAAKAKAREKPVDEPNSHTKKAARVTSDDDDDNREFARQLAKAQEGTKLASKTEGAKQREKSVKQSRANQVSAKAVADKAATAEAAVADKAAADDAAVAAEEGPDVAKAAAVADEASAPSSTAGIDADDDQSPPPSPPAGPRDVSGVSDMLEPAPAPPSVLRITDSGNAQKPNKQKVVKAAEKVETKKQRQNRKKAEAAKAAREAAEKERKVLEERQRRTARVAEGRPAKDGSQSTAGNGARSVWTQGPTNGGGSVSEAPALHGPLDTFEKPAPKQSPPTVKSDSSWISSLPSEEEQMEMLKDEADEWSTVKAKSSKKAVKKASSVSSADEVAPTRPKQVAAATGAVKPSKPAAPSHFGGSFSALTTGDDEVDEVEEEWDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LL75</accession>
    <name>A0A367LL75_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chitin deacetylase</fullName>
            <ecNumber evidence="4">3.5.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_6794</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + n H2O = chitosan + n acetate</text>
            <dbReference type="Rhea" id="RHEA:10464"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9597"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57704"/>
            <dbReference type="EC" id="3.5.1.41"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:10465"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.41" evidence="4"/>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LL75"/>
    <dbReference type="STRING" id="1330021.A0A367LL75"/>
    <dbReference type="OrthoDB" id="407355at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10958">
        <property type="entry name" value="CE4_NodB_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF137">
        <property type="entry name" value="4-DEOXY-4-FORMAMIDO-L-ARABINOSE-PHOSPHOUNDECAPRENOL DEFORMYLASE ARND-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="3" id="KW-0170">Cobalt</keyword>
    <keyword evidence="2" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="6">
        <location>
            <begin position="73"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI15150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="272" mass="30530" checksum="FE3CC4D9C34FB3E4" modified="2018-11-07" version="1">MPRLAQLLRLPNRLRRRVRRNRMATMAALAALAALLLLPLYSAYCVYKPPRFLLSYLRARYPDVLFEMTTTERVMALSIDDAPSSQTADIMAALRENEAHATFFVIGDQVQGREEELRRLVREGHELANHAMHDEPSHALSDQRLEADVAAVKAKLVEAYTAEGSSLPNNYFRPGSGLINRRMRDLMGSRGVRIVLGSVYPHDPQIPYPSVNARHILSMAHPGAIVICHDRRKWTAPMLRIVLPELRKRGYKIVTITDLVKSVEPLGGGHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLJ3</accession>
    <name>A0A367LLJ3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">OBG-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_6481</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLJ3"/>
    <dbReference type="STRING" id="1330021.A0A367LLJ3"/>
    <dbReference type="OrthoDB" id="603at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903833">
        <property type="term" value="P:positive regulation of cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17230">
        <property type="entry name" value="TGS_DRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000003">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000740">
        <property type="entry name" value="Putative GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1070">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="89"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="4">
        <location>
            <begin position="315"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI15281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="392" mass="43162" checksum="C4DB79EB43104E2F" modified="2018-11-07" version="1">MVYFHNASRNDEEEDKFSGAVIIIMSTTVEKIKEIEAEMARTQKNKATSFHLGQLKAKLAKLKRELLTPSGGGGGGGGAGFDVARTGVASIGFIGFPSVGKSTLMSKLTGQHSEAAAYEFTTLTSVPGQVVYNGAPLQIIDLPGIIEGAKDGRGRGRQVIAVAKTCHLIFIILDVNKPLTDKRVIESELEGFGIRINKEPPNITFKKKDKGGLNITSTVPLSHIDHDEIRAVMSEYRINSADITIRCDATVDDLIDVLEAKSRSYIPVVYCLNKIDSISIEELDLLYRIPNAVPISSEHGWNIDELMEAMWDKLSLRRVYTKPKGKQPDYSAPVVLRASRCTVEDFCNAIHRSIVEQFKTAIVYGKSVKHQPQRVGLAHELDDEDVVTIVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LM90</accession>
    <name>A0A367LM90_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18 19">Pyruvate carboxylase</fullName>
            <ecNumber evidence="6 19">6.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">L249_3615</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28 29">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.</text>
    </comment>
    <comment type="function">
        <text evidence="3">Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17 19">
            <text>hydrogencarbonate + pyruvate + ATP = oxaloacetate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20844"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 19">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.1" evidence="6 19"/>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LM90"/>
    <dbReference type="STRING" id="1330021.A0A367LM90"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="UniPathway" id="UPA00138"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004736">
        <property type="term" value="F:pyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07937">
        <property type="entry name" value="DRE_TIM_PC_TC_5S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000003">
        <property type="entry name" value="Acetyl-CoA carboxylase biotin carboxyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000018">
        <property type="entry name" value="Biotin carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000010">
        <property type="entry name" value="Propionyl-CoA carboxylase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.600.10:FF:000002">
        <property type="entry name" value="Pyruvate carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000033">
        <property type="entry name" value="Pyruvate carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000012">
        <property type="entry name" value="Pyruvate carboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.600.10">
        <property type="entry name" value="pyruvate carboxylase f1077a mutant domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003379">
        <property type="entry name" value="Carboxylase_cons_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055268">
        <property type="entry name" value="PCB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005930">
        <property type="entry name" value="Pyruv_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006761">
        <property type="entry name" value="PRK09282.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009554">
        <property type="entry name" value="PRK12999.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01235">
        <property type="entry name" value="pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778">
        <property type="entry name" value="PYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43778:SF2">
        <property type="entry name" value="PYRUVATE CARBOXYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02436">
        <property type="entry name" value="PYC_OADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001594">
        <property type="entry name" value="Pyruv_carbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89000">
        <property type="entry name" value="post-HMGL domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13 19 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14 19" id="KW-0092">Biotin</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9 19" id="KW-0436">Ligase</keyword>
    <keyword evidence="10 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11 19 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="26">
        <location>
            <begin position="36"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="25">
        <location>
            <begin position="158"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="27">
        <location>
            <begin position="574"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="24">
        <location>
            <begin position="1112"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="active site" evidence="20">
        <location>
            <position position="330"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="238"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="583"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="655"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="22">
        <location>
            <position position="751"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="781"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="22">
        <location>
            <position position="783"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="916"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="23">
        <location>
            <position position="751"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-biotinyllysine" evidence="23">
        <location>
            <position position="1153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00072910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRNR" id="PIRNR001594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR001594-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="RCI15555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1189" mass="130505" checksum="F1211D5DF426B5E1" modified="2018-11-07" version="1">MSAPQQALTFNDVFDDDDIDEPKSVHHIRANSSIMQLKKILVANRGEIPIRIFRTAHELSLHTIAVYSYEDRLSMHRQKADEAYVIGHRGQYTPVGAYLAGDEIIKIALEHGAQLIHPGYGFLSENAEFARNVEKAGLIFVGPSPEVIDSLGDKVSARKLAIAAGVPVVPGTEGAVAKYEEVKSFTDKYGFPIIIKAAYGGGGRGMRVVRDAESLQEHFERATSEAKSAFGNGTVFVERFLDKPKHIEVQLLGDNQGNIVHLYERDCSVQRRHQKVVEIAPAKDLPTETRDAILADAVKLAKSVNYRNAGTAEFLVDQQNRYYFIEINPRIQVEHTITEEITGIDIVAAQIQIAAGATLAQLGLTQDRISTRGFAIQCRITTEDPAKQFQPDTGKIEVYRSAGGNGVRLDGGNGFAGAVITPFYDSMLVKCTCQGSTYEIARRKVLRALIEFRVRGVKTNIPFLASLLTHPTFIEGNCWTTFIDDTPQLFDLVGGQNRAQKLLAYLGDVAVNGSAIKGQIGEPKFRGEIIPPMLFDSNGQKVDVSRPCQKGWRNILVEKGPKAFAKAVRQYKGCLLMDTTWRDAHQSLLATRVRTVDLLNIAKETSHAMANLYSLECWGGATFDVAMRFLYEDPWDRLRQMKKLVPNIPFQMLLRGANGVAYSSLPDNAIDHFVDQAKKNGVDIFRVFDALNDIDQLEVGIKAVHKAGGVAEGTVCYSGDMLNPNKKYNLKYYMDLVDKLVKLDIHVLGIKDMAGVLKPHAATLLIGSIREKYPDLPIHVHTHDSAGTGVASMVACAKAGADAVDAATDSLSGMTSQPSINAIIASLEGSDLDPGLDPKQVRALDTYWSQLRLLYSPFEAHLAGPDPEVYEHEIPGGQLTNMMFQASQLGLGSQWLETKKAYEHANDLLGDIVKVTPTSKVVGDLAQFMVSNKLSADDVKARAGELDFPGSVLEFLEGLMGQPYGGFPEPLRSDALRGRRKLDKRPGLFLEPVDLVKAKKELLKKFGGPVTECDVASYVMYPKVFEDYKKFIQQYGDLSVLPTRYFLSRPEIGEEFNVQLEKGKVLILKLLAVGPLSENTGQREVFFEMNGEVRQVTVVDKKAAVENVCRPKADPGDSSQVGAPMSGVLVEMRVHEGSEVKKGDPLAVLSAMKMEMVISAPHSGKVASLQVKEGDSVDGSDLVCRITKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMH6</accession>
    <name>A0A367LMH6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Elongin-A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3373</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMH6"/>
    <dbReference type="STRING" id="1330021.A0A367LMH6"/>
    <dbReference type="OrthoDB" id="21513at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070449">
        <property type="term" value="C:elongin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051870">
        <property type="entry name" value="Elongin-A_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010684">
        <property type="entry name" value="RNA_pol_II_trans_fac_SIII_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15141">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15141:SF76">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06881">
        <property type="entry name" value="Elongin_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="340"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="444" mass="49109" checksum="DFB667C7117FFFF4" modified="2018-11-07" version="1">MPVKSLMELAAMACIKNIKGLESIGDYLPYHSMRHILLKVDNAHQLRQLEVNSPQLQGETGEIWIKIIEKDFPMEFKNNAYKPPTPDKWYRVWEKYKKEHNAAIEESESRLKSALAGLREDKEKNTSKIVERKFLPRAGRVGPKRTLGPRDHSSTSLTFNLGSRTKTNTGASIMRKVRREVKEIATIHGNLSRPVRAGTGASELKKAPAAMIGEYQRAAQPQYKTAAQQPVVEQYEQRATFISDSEPGDDDYDYDREEGDVFGEVVKKPTAASSSTTSSSSSSDTTNKAPLMKRKTGILRASKPMTTTTKQTTQKQDDTTNKPIVSGRGSATLANKFGQRATTTTTTTTTSSTTTNRPRARASSSTEQQVSPEPPTTSTNTSRQEDAEAEGYHLPATKTAKQGAPSPTTPEEVIASLSPPPAQTPLPRKRKAVDIFMRRKKRAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMP1</accession>
    <name>A0A367LMP1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_3443</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMP1"/>
    <dbReference type="STRING" id="1330021.A0A367LMP1"/>
    <dbReference type="OrthoDB" id="1937934at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22439">
        <property type="entry name" value="KH-I_PCBP_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22455">
        <property type="entry name" value="KH-I_Rnc1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22456">
        <property type="entry name" value="KH-I_Rnc1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="110"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="193"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="391"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="358"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="361"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI15715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="467" mass="48583" checksum="4291449A75F3D47F" modified="2018-11-07" version="1">MSASPPQPTQSAKRPLEEASSPSRATDQPDAKRPALDKVIKAEEEAETAETALDVPGQASNDESTAGQSDQSATAAAGTASMMPSAAAASAVVAASESAVGSAAANDETAWIHIRAVISSPEAATIIGKGGENVSNIRKMSGAKCTVSDYQKGAVERILTVSGIVDAVAKAFGLIIRTLNNEPLNEKSTTASKTYPLRLLIPHILIGSIIGKGGARIKEIQDASGARLNASDSCLPMSSERSLVVMGVADAVHIATYYVGSTLLEQLNEKYGGPAASAYATRSGAPVGSIPGGMQVVPYSPQPAGGHFGRAENYGRHQDRRGGHQMAAAPYGQQYSHGAGQANAAMPMHYGAQAAGYGASPHAQPHMAHHAAQQTHGGPQGQPMHTGMPGGPITQQIYIPNDMVGAIIGKGGQKINEIRQLSGSVIKINEPQDNSNERLVTVTGTEECNRMALYLLYSRLESEKHRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMP6</accession>
    <name>A0A367LMP6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anaphase-promoting complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_3442</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMP6"/>
    <dbReference type="STRING" id="1330021.A0A367LMP6"/>
    <dbReference type="OrthoDB" id="5581181at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044554">
        <property type="entry name" value="ANAPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014786">
        <property type="entry name" value="ANAPC2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057975">
        <property type="entry name" value="TPR_ANAPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45957">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45957:SF1">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08672">
        <property type="entry name" value="ANAPC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25773">
        <property type="entry name" value="TPR_ANAPC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01013">
        <property type="entry name" value="APC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="8">
        <location>
            <begin position="542"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="770"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="784"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI15714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="885" mass="97883" checksum="B7E6993F3C7AB410" modified="2018-11-07" version="1">MRARRANIFHSVFQPDATQPTSLLTGVRLHAKNANDEVDDENDDSPRGHQIRWDRAWSAVTSRIQLPTSVSVEDSFGTVPSESQQDLDDFFGDALAVVLDPASAVPQAAHTGDVLLWHSRQVRHHFVHHVLPLLAACAAQEDPSKVLLSSAQTLQAAHRQYSHGLTLLVRGIHQRHVREAAVAKFRRELHALVSSSWAAGLALALRTVLARLLSDVLMVDVSRPHRGAAEQPTKAQVSDRAHTELLSLLESLQTIGLAGDSLHVLLAEIMDRCMTDFIDHAYAGVWAAATSSSSSSSSAPGIMDRCMTDFIDHAYAGVWAAATSSSSSSSSAPRCMEHLCAWIDGHYGRVAAQVFGCLGGRVSSEDVERWREVAVGRLATLRIRELFNMDLRSAVTTPQRRLQLTDAFSAALQKRLLHPGRSTLAILQTYIAMIRTFHALDASKVLLDRVAYPLQLYLCQRDDAIRIVVTGLLANPKAADEDEGSKNRLVELAALLNDASSQQRGGRNEDDDLDWNDMSWVPDPVDAGVNYKRPRSEDVIGTLIGALGSHDIFIKEFQLIVAERLLSTQSDFHQEVKVLGLLKKRFGEVALQNCDVMIKDIYDSRRVDATLGKNLRPWPGVPAYHSKILSRLFWPSLRMEGFRVPATVAAAQSRYEAGFEQLKTARKLGWLDHLGSATVRLELEDRSVDLQCATYEAAVIYAFHDDGANVTPRRRTLNDLWQHLRMDEDLLALALSFWLSKQVLRNVGNQTYEVIERLGSDANTTTKAVAAAAGSGTTSRDEEGGGGEEEDDEKDGDEEVSLRKPSRLVDETKEKERRGVYWQFIVGMLTNSSPAMALGQISMMMKMLISDGCPWSNEELQDFLGERVVAGELELVGGKYRLPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LN15</accession>
    <name>A0A367LN15_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_2487</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LN15"/>
    <dbReference type="OrthoDB" id="1932312at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040324">
        <property type="entry name" value="WDR44/Dgr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221">
        <property type="entry name" value="WD REPEAT DOMAIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="332"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="372"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="298"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="735"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="779"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="860"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="19"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="54"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="98"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="737"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="789"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="860"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="895"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="930"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="964"/>
            <end position="975"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI15835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="975" mass="104818" checksum="B53F9E366DD9EE7B" modified="2018-11-07" version="1">MSAQLLSPADAPSRGGNQSPSAGSPAARPSPTTTTTTTTTTTTMSRAEPTQKGLSSAARRSTSLLSRADVPQGAKDKDPGRNQHKTLTNPPPAALDPLSTQIFLRTNSTPSEPSIAHRLRNPSRPVSPASDHHLHDTPNKLSNGVAETSRERRKGTSFLSRLGMRAARKRDDDMPDSDSELGDARTDGNDARALTSVVGDGGGYIPLHRGPTTYIRVKSHNKKGRQYNRLFLAQELLGGTKNAVEDDVQARAPATAVGTKILKAGDAIWAAEFSVDGRYLAVAGKDQTVRVFSVISTPEERKAHEEEEATQNRGNGERLSAPVFHSKPTREFEGHTGEVLALSWSKNNFLLSSSMDKTVRLWHTSRTECLCVFSHDDLVTSIAFHPTDDRFFLAGSLDAQLRLWSIPDKAVAFSVQATEFITAVAFAPDGKTAICGLLNGQCMFYETEGLVFQFHIHVRSSRGKNAKGSKITGIRTAGVPPDTDDGDVKVLISSNDSRVRIYSLKTRMLEVKFRGLENQSSQIHARFGDDATQVISGSEDRRAYIWAAGSAEAEFKDKQPYECFDAHPQVVTTALMAPVKSRLLLSASGDPIYDLCNPPPVTLMSLDERTASETKVSDGPSTNGLPAIKRPEESPAYIERRRHPGGDIIVTTDKSGTIKVFRQDCAHAKRLQNTWETGSKFSGKLAGIDRSASIVTRTSTSSRVHSRRGSLGQGPFPALAQLASDRIMSWRRDIEGRGSSSGAASISERSMSPNKPQPAPVNTSAANIASEARRLPYAPGSVVRSNQPSSPTSSLHTSRTSLRLARDKDQAQPLPPTPSFSLISASDSDGHHEDKAEGGFWVRWRGGISARRYLQVAGSSASAANQVATTADRGGSEASALKDKTTTTTTTGRLSIDETRKAKLGDEEARRKSAVPSTLGLLKLSESEGSEERPAVSDQRVDSGVGHGSTNGIGDADGSATSMVEDKTPQERSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNB7</accession>
    <name>A0A367LNB7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_2522</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNB7"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI15936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="81" mass="9234" checksum="E12602BE138DD645" modified="2018-11-07" version="1">MRKKCGEKVFCGAVEEEEGGKKLVESLEEEDELRNSGFVIIEEELKAGEVGKPPSFIDKFLNNKVQRVDRCDDHCNDRCDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNQ1</accession>
    <name>A0A367LNQ1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_1975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNQ1"/>
    <dbReference type="OrthoDB" id="4931909at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016595997" evidence="2">
        <location>
            <begin position="21"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI16017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="370" mass="41875" checksum="F4B1EB1963EC349F" modified="2018-11-07" version="1">MKSLLLTLFLPLLASQPSLQAATKVNQEAVSEKQMREQIEELEKNIQIDQKTSISHRLSWREDTCWTVWAACPGGTYFDETRKMLSPFNTSIFIKREVIRRVRNVQSSDSVSLRNEKSTITVDTTTSGWSITADASAGSWNPISGASKGLSISGGYSSTTTTGQTLSMSESSSSTCPPRHRCWIEAWTAYVRVKGSCRLQPKVSCYHSVDNICLEPDTGDRWFFCANVQEYRDKPGVCDGLDGAVDDCEVVTPIMEGKRPFFVEVFFEEPIKSLYPKPKITGYQAGYYILDGDGDYRYFPTRVRDPFWTPEAKYHANAVYPRLDDEVAEFKHPVPTLETPEPVGDCYKLITLEYYCPRLPKKYWSKDADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNS8</accession>
    <name>A0A367LNS8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">DNA polymerase alpha subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_2079</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DNA polymerase alpha subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNS8"/>
    <dbReference type="STRING" id="1330021.A0A367LNS8"/>
    <dbReference type="OrthoDB" id="336885at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.60:FF:000005">
        <property type="entry name" value="DNA polymerase alpha subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.60:FF:000008">
        <property type="entry name" value="DNA polymerase alpha subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016722">
        <property type="entry name" value="DNA_pol_alpha_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054300">
        <property type="entry name" value="OB_DPOA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061">
        <property type="entry name" value="DNA POLYMERASE 2 ALPHA 70 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061:SF12">
        <property type="entry name" value="DNA POLYMERASE ALPHA SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22062">
        <property type="entry name" value="OB_DPOA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018300">
        <property type="entry name" value="DNA_pol_alph_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha subunit B OB" evidence="9">
        <location>
            <begin position="199"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="8">
        <location>
            <begin position="347"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="120"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR018300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI16059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="642" mass="69016" checksum="CA17AD82CFB92ED9" modified="2018-11-07" version="1">MADEETELAARFAPGGKLEADVAAELTSIMRLYELSVQDTLFKWESFCLRRNLDANDVSLPAVRDLKGSIHDELERERSKSLAKAGKKAVEPGSMRAGAAAAAASVMNLLGDVMPVTPRARAKSKLDSSPATGGEHSTSSSFGDRAKSGEVIEVLNGHLPAAKATTTTTYHETRIKLTAASDQTKMGYKPLAMKLSETSEVLDDRIDDWAELVRDHHGLDESEFGNAAAQGTTEMVAVGRIASDAVTDEGRLNAASLVLETSRRTGMGFRVPLNLDSVSRWSFFPGQVVALRGSNASGTDFVVREVLEAPLLPGAASAAAALDACRERLRGGRRDEGEGKEPAPLNVIFASGPYTADDNLDFEPLHALCSRAADGLVDAIVLAGPFIDVDHPLIASGDFDLPDDVGIDPDTATMTTVFRYLFAPALNRLASSRPQLTMMLVPSVRDVLAKHVSWPQDAFPRKELGLPRTARILSNPMTLSINEMLLAVSTQDILYQLRGQEVVAKGAAAAAQGDVMARLCRYLIEQRHYFPLFPPTDRQRLPRTGTEDGVATGSVLDLGYIKLGEMVNVRPDVMLVPSALPPFVKVVESVVAINPGHLSKRKGAGTYAHMTLYSPEASNGVEADAIVGHGIFDRARVEIVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPC8</accession>
    <name>A0A367LPC8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ER membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_1902</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPC8"/>
    <dbReference type="STRING" id="1330021.A0A367LPC8"/>
    <dbReference type="OrthoDB" id="5577218at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048309">
        <property type="term" value="P:endoplasmic reticulum inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000921">
        <property type="term" value="P:septin ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013635">
        <property type="entry name" value="Ice2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31726">
        <property type="entry name" value="PROTEIN ICE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31726:SF2">
        <property type="entry name" value="PROTEIN ICE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08426">
        <property type="entry name" value="ICE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016663159" description="ER membrane protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI16241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="430" mass="47189" checksum="A96B2CF83F335CB0" modified="2018-11-07" version="1">MWWLFSVILGFVFLLSIVLSIPVAFDVGGRDSGLAYSLSIFIYYLAYSAIRIATSDGSRFGRSVSAALRLSQWFVVPTLMIWALGQFAVDAGSTDWVERTVGGVFRSKSTTWTGWLFGKDGLLETVMLCSWDGGLKYSGPIFQLLEGFCTLLVIQAAGQITRWLVNRGRSDTWLIILLAFSGSVMASSVYFLWRVVQFPQIGNLDATLIGIAMTTAVFLCAYGIGSGRGNPVEGSLLFAYVVLCVYQIFTDYLPSDGTGQADEATQPDIPPLPPIIMASYSTLLHMLGSLPSAMHSTLALLYAAFQTITPSVIISLTYRLLVFYSATRIIPSVRDLGARALMHEPDFDDSETANKVLGVLSWFSPSILVAVYTSLLLQHFSTNDGPDGWTLRGGDVGGGHWRWINVGLTMFLYGVELYLGTDEQDHWKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPN3</accession>
    <name>A0A367LPN3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_3148</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPN3"/>
    <dbReference type="STRING" id="1330021.A0A367LPN3"/>
    <dbReference type="OrthoDB" id="2328572at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="20"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="30"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="66"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI16369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="221" mass="24454" checksum="7153317FF76437A1" modified="2018-11-07" version="1">MQNLRRAYDPITARSNLHQACDRCHEKKLKCSGDKEGCDRCATSGHPCKYKRPRSRSSRKNNSNRSDPEPTESSRRGRETMSHQHQHQHVSPPRRTPPAASKPRSHAARIGSPLPAAPTTTQQTVPYWEEAGLAVANQSVFGDQGLAGGYGLHLFPSQHLAPGPQDWTTDGPYAATASDATYSAAESQVYDFGPSQMAFDSFPVFEDYQAFDPRYWAPGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPY9</accession>
    <name>A0A367LPY9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_1731</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPY9"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI16479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="69" mass="7738" checksum="4F164ECE39C29F4C" modified="2018-11-07" version="1">MILMEARLFGDVRQLHSLFLTLWLKVYGVLPLYDRLFLISSAEVVEITYLPVVNALAAPGWFNKGSLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQ35</accession>
    <name>A0A367LQ35_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein BFR2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_2642</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AATF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQ35"/>
    <dbReference type="STRING" id="1330021.A0A367LQ35"/>
    <dbReference type="OrthoDB" id="5783963at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025160">
        <property type="entry name" value="AATF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039223">
        <property type="entry name" value="AATF/Bfr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012617">
        <property type="entry name" value="AATF_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15565">
        <property type="entry name" value="AATF PROTEIN APOPTOSIS ANTAGONIZING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15565:SF0">
        <property type="entry name" value="PROTEIN AATF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13339">
        <property type="entry name" value="AATF-Che1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08164">
        <property type="entry name" value="TRAUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AATF leucine zipper-containing" evidence="5">
        <location>
            <begin position="246"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="Apoptosis-antagonizing transcription factor C-terminal" evidence="4">
        <location>
            <begin position="429"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="511"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="10"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="162"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="516"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="541"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI16529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="556" mass="62151" checksum="D2DD71FED4B0962E" modified="2018-11-07" version="1">MAKSLGHAQKLAEFDETIIRDDDIEGEVPRGDDDSGSDADEENAATKHYVSVGRSRLRDKDSVSLGRDYRGSRVSRWALEEEASEAEVSEGIGSSEDEFDDPEAADLSADEAQAGDSEIDSDNAFVESDAERFDGFSFRGSSRPRLSATRSKDRASAADYMTSDEEDDDESGVSNEEEEGDNQSDVSNEEEEGDNQSDVSGKEEEEEEEDASADDNEGSVEDERVGAQEEAQWRPGEQNVGSKQTDREKGMAIQKQRKIYDGLLNLRIRLQKALVAVNTLPTLDDSGPGSDTEPYEAAEEAAIKLLNTMSNLRDNVSSQRTGDKRKRRLSCSMSSEAIWGYIDEEDKQAGDFRRERLDKWWRKVQSVVVTAPRGLGQRNKTLVEGLEEQVANAEGRLVKRTRVPRSCAPVQAGRKLTEDEQVYDDADFYQLLLKELVDQRTVETWAAQSSGVRSVMLTATKERKQVDRKASKGRKMRFTVHEKLQNLMAPEDRRSWEETAINRLFGTLFGQKMTLNEDEDEDEEGEGEGEGEGEGEGDVVEGEKETLDQRGIRLFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQE8</accession>
    <name>A0A367LQE8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_1908</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQE8"/>
    <dbReference type="STRING" id="1330021.A0A367LQE8"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000549">
        <property type="entry name" value="ABC transporter ATP-binding protein arb1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000618">
        <property type="entry name" value="ATP-binding cassette (ABC) transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF15">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="90"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="6">
        <location>
            <begin position="401"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI16648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="622" mass="69095" checksum="DBD2D879CE139AD7" modified="2018-11-07" version="1">MPSASKEKRLAKKAAEGKLDKKNGSSRGTRTPKNEPQVDANGNPVENDAPATSGEKLDEVKRLADQMDKHGISDRVTTGVLASTATSKDVKITSTSLVFHGRVLITDSTLELSFGRRYGLLGENGCGKSTLLKAIAAREFPIPEHVDIYLLNEGAPPTELGALEWVVREAEAEMERLDKVAEKLLEDEGPESPVLIDLYDHMDKMDPSTFATRASLILTGLGFNKKTIHKKTKDMSGGWRMRVALAKALFVKPSLLLLDDPTAHLDLEACVWLEEYLKKWDRTLVLVSHSMDFLNGVCSNMIDMRQRLLQYYGGNYDSYHKTRAENETNQMKAYNKQQEEIAHIKKFIASAGTYANLVKQAKSRQKILDKMEADGFIQPVVPDKVFTFRFADVEKLPPPVLSFDNVTFSYSGNSADDLYRNLDLGFDMDSRTALVGPNGVGKSTLLRLMTGKLSPTSGAVTRHTHLKLGLYSQHSAEQLDLTKSALDFVREKYREKSQDYQYWRQQLGRYGLSGDSQTALMGTLSEGQKSRIVFALLAIDSPNMLLLDEPTNGLDIPTIDSLADAINAFDGGVVVVSHDFRLLDKIAKQILVCENQTIQTWDGSIGEYKNYLRKKMISAGAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQG6</accession>
    <name>A0A367LQG6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhamnogalacturonase A/B/Epimerase-like pectate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_1734</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQG6"/>
    <dbReference type="STRING" id="1330021.A0A367LQG6"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23668">
        <property type="entry name" value="GH55_beta13glucanase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000023">
        <property type="entry name" value="Exo-beta-1,3-glucanase Exg0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039279">
        <property type="entry name" value="QRT3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928:SF2">
        <property type="entry name" value="PECTATE LYASE SUPERFAMILY PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928">
        <property type="entry name" value="POLYGALACTURONASE QRT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016834912" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="2">
        <location>
            <begin position="56"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="2">
        <location>
            <begin position="400"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI16482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="773" mass="84184" checksum="794E3FBFB191576D" modified="2018-11-07" version="1">MALRTLLTASVLALGLVSPVQASVDRRQNDSCEWWMSSIKRQGSAPYVEDASYPVFRNVADFNATGDGQTDDTAAINAAINYGGRCGVGCPSSTTRPAIVYFPPGVYRVSDSIVQTYHTQFIGHVRKPPTIKADKTFKDASFVIDGSPYQPDGNLTWKATDNFFRSIRNLVIDMTEVEGKTISGIHWPVGQATSIQNVVFNMAPYQDESTVQQGLFIEEGSGGFLADLVFNGGKYGMAVGSQQFTSRNLVFKGCQTAIHMYWTWQWIFHGVSIDSCEVGIELPAPVGSVMLIDSNISNTKTGIVTAYDATQPFTNGSLVLENVDMSTNVSAAIKKNESVILEAGSNIAFWAQGRSYVGDKGESVQGPMPAAVRPRALTDDNGRLFTRKRPQYNMVPASKFVSVKSAGAKGDGVTDDTQAIQAAFENIGQDEIVYFDHGVYLVTDTVQIPPNVKIVGEVWPVIMAGGNSAFKDQANPKPVFQVGQEGNMGNVEIQELVFQTSGAQPGAILMEFNVAGETKGAAALFDVHFRLGGSQGSDLQLEQCKREPGSKEIKENCLTAFQLMHVTKHASVYVENSWMWTSDHDLDAPNPKADPDAVQITVYTGRGLLVESTAGSWFWGTSSEHNVLYNYLLNGAEDVFLGLIQAETPYYQGNPLAPLPFKPHADYSDPDFSECSPDEPKCARSWGLRVDKSKGVSVYGSGLYNFFDDYDKQCQDERWCQDSMISVSSSSVDFYGISTSASRNMIVLDGKPAAVEADNVNNFCSTVAVFRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQI8</accession>
    <name>A0A367LQI8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQI8"/>
    <dbReference type="STRING" id="1330021.A0A367LQI8"/>
    <dbReference type="OrthoDB" id="4174342at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="478"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="582" mass="63378" checksum="06AF3047B4AC386A" modified="2018-11-07" version="1">MSIFVSAFSWAQYLVALYQNMALGLSGIVALCLLTQWVGCGAVDNSQSMSSDTVSSLFPDRPIRPLPKRRLRERLSPEVAQSIKYPPTTYDTVSLFYYPPFTLKKEGAAAAGSEPANAVEPSRRSELGSAPAFLRNGLGHGVEEEEGSRVRGALFARSPPEILSRAARNPFRPDQPRPADPQLPPSAASSVDGYDSFENTNNKKKRKIPSAGDSAINTAHSLNNEISSLAISAGAHSPVNDAVGDRPLHGSTGYPASGSYVPNNPGFSGPGRGRLGRSRNGRSPLRALSDSNNGWPARLSKTGPSPWSTVPENSGIISNAIANAERMASQGHEKVSLLQQHSAAVKNTPASTQFTFTCDSHVPGTVQWPGHPSKYNMGSQQSSCNSANNDSSKAGGADARQSRTKSRRHLERELKAAARQRRRKASDLKHSLKAEDVWICEFCEYERIFGVAPRALIRDYEIKDRRLRQEEADRKRLLEKAKAKSRKGRKAARSGNRAGQGASHTTDQVPGEATDEPDAPDMHHNPSHSTQSEEDECEDDEVEEEKPQHVEQRVEQGVEQRGHVVLHIGDSRGRFTSQRTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQL4</accession>
    <name>A0A367LQL4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQL4"/>
    <dbReference type="OrthoDB" id="4931002at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="9"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="277" mass="31096" checksum="FC7542C5ACB22F47" modified="2018-11-07" version="1">MLRYSFALRSRSGLQRQQQQQRQQRQQAQKDHLITGCQEGGRTRGPRQQTSRPSSSFSFLRQGRRGIQQFLDQFEEKVPEQRVLTEDLPWPAAKTALLRYYGAFDQIRTVGFYEKLRRHEARRPKTKDTIDWLEKHAFLCRKIGSGYGPGPGPGPGPDESTEHSYGLFQALPKEIQVQLYDQLGQRPSSSPYGILHSHTHTQGTRPEGLGGSRDAGPAAAGPRPPYVTEAVRGGYGTATPYSGYGRTGRTGRTKEEERRVEQDKQGVPSSKIQSVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQV1</accession>
    <name>A0A367LQV1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_1723</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LQV1"/>
    <dbReference type="OrthoDB" id="5129394at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05274">
        <property type="entry name" value="KR_FAS_SDR_x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF49">
        <property type="entry name" value="SYNTHASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="12">
        <location>
            <begin position="7"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="13">
        <location>
            <begin position="907"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="11">
        <location>
            <begin position="2399"/>
            <end position="2476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="435"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="9">
        <location>
            <begin position="907"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="9">
        <location>
            <begin position="1051"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="9">
        <location>
            <position position="939"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="9">
        <location>
            <position position="1114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI16826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="2484" mass="271185" checksum="02C5163F16F6A59D" modified="2018-11-07" version="1">MTQQPPLSPIAIIGMGLRLPGGVSTANEFWDLLINKQDGRRRVPPDRFNIDGFHGEAAHRQKVASQHGYFLDANIKAFDNDSFPSNAADLERLDPQQRLLTEVAWEAMESAGQASLRGSDTGVYVGVFGEDWHNIMHQDRQRTGNSRSIASGDFALANWLSYALDVRGPSMTIRTACSASMSALHLACLALRNGDCQSAIVAGCSIIMEPSMTLVMSEQQVLSPTGSCKTFDASADGFARGEAINAILIKPLDAALKAGDPIRAVIRATAANSDGRISSMGCPSAEAQEVMIRNAYKAAGIDDISLTPYIECHGTGTPVGDPIEVAALAGAFGRRGAFIGSVKPNVGHGEGASGITSIIKAALCLENSTIPPNINFCTPSPRIPWDDYKFEVPLEPMPFPQGRPARISVNSFGIGGANAHAIVESAAAYGIPARLTNGHSTGSPEEKRQEGDDNTSWPSVLPVSANTENSLQRRIADIKAYIEAHAGSVDDVVYTMGVRRLHLAFRSFSIVQDGVARPPEFSSVEKAGACKAVFIFTGQGAQWEGMARSLMLSSPSFRRDIKEMDDGLRMLDEPPRWTLQDLLESGVEENDNYINEAEFAQPLCTAIQIALVNFLAKCGVTPYAVIGHSSGEIAAAHAAGALTVSEAIMCAYLRGQTTRLKTRDGLMAAVGLGRDATVPYLVDGAIIACENSPKSVTISGDAEAVRQTLEEIKAKEPDTASRMLHVNVAYHSHHMREVGAVYQERLSPCMKQIREPRIPFFSTVYGKAVDSETRLGAEYWRKNLESPVLFHGAVSNLLTGLPDVATVVEIGPHSALQGPLRQIFQERTSKKPPSYVATLIRSKECVESILGTVGQLYARGYDIDFSFLNPKASTLVDLPTYPWDHGSDFWKESRVSKAWRMKENPHHELLGDRCPESSTLEPVWRNVLHHSDVPWLADHKVGTNVVFPCTGHVGIMGEAVRQALGGEKGYVIRNLTVKAALVFPETDPIEIMTTMRPSRLTDLTNSSSWHEISISTLNGETWTENCTGQAMARIEEATSTNDGTGLDPGGSYSRQMAKGYFYDHMRHMGLRYGPRFQGLTDISTDPKRSVAMASLKDSSAEKETPYLVHPATLDCCLQLPVVAGCRGVARSIDTLMLPVSIRRIVIHPGGETDLEASAVVDLDASDVRVVVVSRRSRRPVVEMDGIRGIPFDTGDAAGGRNGLMSACLEWLPDIDCLSAVELTMERRDNKREPRKIGEKLTSLGILQTLDVIESLDVSPSGHLAKYIVWLEEEKQAMIRGDRPLAFPEEQEWALMKPSALKDLAKTMLVELEATEERTVINVGHMIYDMSQQETIEPIFRGTNPVELIVADDRINDFYTFQCSASAAEFFRLCGHAKPTMKILEIGAGTGSTTKDVLDSLVSEHGVRLYEQYVYTDISPWFFTAARERFKDRNNIVYKVLDITKSPEEQGFELESFDVVVASNVLHATPSLHETLRNVRSLLKSDGRFYLTELVKPLSWRFINFITGRLPGWWVGEADGRADVPFVSVERWDAELRAAGFSGVDASVLDDDEPYCTCAHMTSRAVAAAAAAKPETVVMLYRHEKNEFACGLADIWARGGIDVRWAQLGNHGEDLVGVEHVISAVDLEGPFFHDLAETDYQAFMALLKKLQRGVLWLTRPAQIACIDPRYGLVNGVARTVRVELSLDFWTAELQGLDETTTAAVLSIARKFFSRPSLSRGMDTEYAVHDGIVRVARCHWSSVAGALEPAKDGGCARQLVVGQYGVLDSLTWIRAEEQTVGELDVEVDIRCVGLNFLDIMVAMGLVPKPKDSLGAEAVGVVSRVGSAVKHVAVGDRVWAVRLGVFATRKVVPGVFVYRMPDGFTFEEAVTMPIVYATVIYTLMTLGGLRRGQSVLIHSAVGGVGQAAVHICKMLGAEIYATVGSETKVDYLIKNHGIPRDRIFNSRNDSFRDDLTQATDGKGVDIVLNSLSGDLLHASWECVAKGGKMMEIGKRDILERGRLALNMFQDNRTFYGFDLVALLRDRPEVFPELIGQFLGFIAEGHIKPVQPIHQFSAQNVADAVRFMRSGDHIGKIVITIPEDPTEISCTKLAYTGGLLSETSSYLLVGGLGGLGKGVTRWLVEKGARNFCFLSRSARKSEGDQVFFRELEEQGCRVAAVAGSVANMAEVQRAVGAAPTPIAGVLQLSMVLRDNSISQLGFDDWRAAQQPKVQGTWNLHKALVHTKLDFFILASSLSGTFGQPGQVNYASANSFLDSFVQYRHGLGLPCSVVDLGAVEGIGYLSDKQSKLNVYKSFGADLLHEQNIMDAIQLAMKRSLPPNTMGLTSPRGPLANKSQILVGLTSSKPLNDPTNRIPFKHDARLGLLNNMVTASETTLQSRDQGISQLINKFEANPGLLSDPDAITQVSHEIGRILFRLLLLPEDTLDTSMSLASIGIDSLASIEIRNWWRRTLGVDKSVLEIMNAGTIEGLGKLAISSLKKKHEGDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQV2</accession>
    <name>A0A367LQV2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine-threonine kinase receptor-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_1711</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the WD repeat STRAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQV2"/>
    <dbReference type="STRING" id="1330021.A0A367LQV2"/>
    <dbReference type="OrthoDB" id="408728at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032797">
        <property type="term" value="C:SMN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877:SF13">
        <property type="entry name" value="SERINE-THREONINE KINASE RECEPTOR-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="65"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="301"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI16767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="353" mass="38161" checksum="1120B830E0CD3A41" modified="2018-11-07" version="1">MSAEGHRSYVPLTCHGHSRPVPHFSFSNLEKDGQYFMISACKDGNPMLRDGINGDCSTTPRVGTFLGHKGAVWQARLSPNLAYAATASADFTAKIWDTHSGEQLVTLQHDHIVRAVAYPPDNSDLVATGGMEKKLRVFDLSELTAANAETPLTIPASAGFEIGEGVHTGSIKFICWTQDPNIVVTASEKTLRWLDLPSRTCVHHEVLDGEIKSCEMVSLSAEHTSSEDIGGGKPVLAVAAGKTAYFWGGSQAMDELKRIVLPRSIASVALDVKGRKLVVGEEPGTWAKVIGYDDEVELETLKGHHGPIWSIAYAPDGKLYATASEDGTIKLWKNCDGQYGLWKGGANQERSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQW8</accession>
    <name>A0A367LQW8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="9">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L249_1887</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Lipid-anchor</topology>
            <topology evidence="1 9">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="9"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQW8"/>
    <dbReference type="STRING" id="1330021.A0A367LQW8"/>
    <dbReference type="OrthoDB" id="421038at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03390">
        <property type="entry name" value="PAP2_containing_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000038">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012946">
        <property type="entry name" value="X8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF2">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07983">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00768">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 9" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017058697" description="1,3-beta-glucanosyltransferase" evidence="12">
        <location>
            <begin position="16"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="619"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="653"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="733"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="763"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="791"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="domain" description="X8" evidence="14">
        <location>
            <begin position="376"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="13">
        <location>
            <begin position="655"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="325"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="857"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCI16854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="882" mass="95542" checksum="904AFE2D2C8F6A61" modified="2018-11-07" version="1">MLSLSLLALAGSVLADLPSIEMKGAKLFYPNGTQFFMKGVAYQQDIAAAGQSSAKTHYSDPLSDEDRCKRDVKLLKELGTNVIRTYAINPDMDHSGCMRLLQDAGIYVVSDLSEPKMSINRDNPQWDTVIFSRYQKVIDELSRYSNVIGFFAGNEVSNNKTNTQASAYVKAAVRDTKAYIKNKKNSRWMGVGYAANDDRDIRKEIADYFNCGKAEESIDFWGYNIYSWCGQSSMQKSGYDQQIKFFESYSVPVFFAEYGCNIPGGADGRIFQETAALYSNEMTKVFTGGIVFMYFQEENDYGLVKITDGKAVKGKSFETLQKQLTKADPKGVSRDSYSPNNKPQKCPDPKSANWKANSALPPTPDQSLCDCMVKSRSCVQKKGLTPDDYSSMFGFICGAAPEVCTGIRGNASTGVYGAYSMCSDSAKLDFVLDAYYAKQNKDSSACDFDQKAGLQSGSADSSCDAKLARASDINKHAATATAPIGGGATSTDDSSAAPGMPMPRLLAAGDYTMGLYVAAAGKDMAAVFIRIVSPTPAMAPTGNGPESERRPGSVVRAVLGFVKEWVHLNGIDCGCLAAVGVATFAIYHARVPVTRTFPVTFSGSGDVVYPEWAYPYRGWIIPSWASGVVAIGGPILIYGVAQIRIRSAWDASCAIMGSIWAVLLATFFQVVLKQLIGGFRPYFLDVCMPDVDGFADRTGLNGVGFQSVMYTVDVCTQTDGALLKTAITSFPSGHTSATCAGFGFLFLWLNAKLKVWADHQPAFWKLFLTMFPVLLCAVISCSLTIDAAHNWYDIVGGAVIGLAMALAAYRASYAAVWNWRFNHVPLHAKGAFSYSAADPDVAALTLTRTAGWGDEGNWLPRHADDTATGGDATLRTGRNDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQY0</accession>
    <name>A0A367LQY0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_3335</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQY0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI16632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="57" mass="6392" checksum="82F78B06691C0CE7" modified="2018-11-07" version="1">MLIILPIPTCSTLTYLYTCTCRSDRSDRSDPITPAMTAMTRPLWPLAVLRGVGYKMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQY2</accession>
    <name>A0A367LQY2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_2945</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQY2"/>
    <dbReference type="STRING" id="1330021.A0A367LQY2"/>
    <dbReference type="OrthoDB" id="272139at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16023">
        <property type="entry name" value="GPI_EPT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037675">
        <property type="entry name" value="PIG-O_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039524">
        <property type="entry name" value="PIGO/GPI13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071:SF1">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="471"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="525"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="552"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="583"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="611"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="636"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="685"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="716"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="755"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="939"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="971"/>
            <end position="993"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI16760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1008" mass="109821" checksum="30DF9038E20DC106" modified="2018-11-07" version="1">MTTPSSSTMPPDPSLNQLRRKAFEHRWRWTVAFWLWILVIHVGTVWLFASGFLLTRLVLEEKSDCGSPPTDGGKLASLDVDGGCWHPRTFDRAVVIVIDALRYDFTVPTDEVVPRQFHNALPFLHASAAAQPRHAFLRPFIADPPTTTLQRLKGLTTGTLPTFVDAGSNFAGTAIEEDNLLMQLRRSGKKIAHLGDDTWWSLFPGYFEANISRAYDSFNVWDLHTVDDGVMDNIFPLLEEGGRRGQWDLLIGHCLGVDHAGHRYGPDHPAMNAKLRQMDEFVGRVAAAIDDDTLLVVMGDHGMDAKGDHGGESDDEVEAALWMYSKRPVFGRTSPEHETPPPTAKVRPVNQIDLVPTLALLLGIPIPYNSLGRPIEEAFAAEAFAAGGWANLAAVSRMAAAGVERYQKSYFAARGVTPDGGPDSPADLWARANNGADGSRPRETHEAFVRFQERTLQVCKGLWARFDVPRMVAGVFIAAGGVLLLALYASTDDDDDDDEEARGKKTEAKRHPDQSYHVDLLRGLWNVRFLAVAALAAAVIIMARRDRSVDGVPAIVMALMVATVGSALHGAGKTLANSLPRSVWGWLSVVFAVVHSLGFASNSYTVWEDSILLFSMATFGAVAAVASFRIENRTDRALAVYHCIAFVVLGRAASYSKLCREEQMPYCTSTYYASASSSTSAPWQLALPFAVFAALPSVIKSFLTPTRSYEGLAPTWIGYVFRGGLFMSAVYWVVDAADNGDWLAGRLEAGWLKAAGVYLAQLSLALAVVAGTTAFTWAPPCVSVVPAGESRVAILGYGNALGARYLLLPLNVLAACMVVTKPMGGGALALMFWQVLSLAEVLDLNGLKAETTGPVVLAMLGNFYFFRTGHQAALSSIQWDSAFVPLFSIRYPWSPLVVTVNTFAGQVVAASSVPLLALWKSGPGERRALEKTARGAAAFIGYFAFEALATMTWAGWLRRHLMLYRVFSPRFMMAAVLLVVLDLVVVFVSLTGLRTNMLSVSDVFGWEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LR42</accession>
    <name>A0A367LR42_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LR42"/>
    <dbReference type="STRING" id="1330021.A0A367LR42"/>
    <dbReference type="OrthoDB" id="2687452at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="16968" checksum="389021F9A7DEE649" modified="2018-11-07" version="1">MHSKNNSCTSRPFKRRADLDRHYKHRHAPDSVKDAFICDYPRCSRHQDPFHRLDHFRDHLREFHKEDIEKRSNNNNNNNNNNNNNGLDELQMPSATAMTNGWWRCRRCLKRVHHAGACPTCKTPSQPRRKDSSNNASHVTRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRE7</accession>
    <name>A0A367LRE7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Knr4/Smi1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_2064</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRE7"/>
    <dbReference type="STRING" id="1330021.A0A367LRE7"/>
    <dbReference type="OrthoDB" id="2305498at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070880">
        <property type="term" value="P:fungal-type cell wall beta-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018958">
        <property type="entry name" value="Knr4/Smi1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051873">
        <property type="entry name" value="KNR4/SMI1_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47432">
        <property type="entry name" value="CELL WALL ASSEMBLY REGULATOR SMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47432:SF1">
        <property type="entry name" value="CELL WALL ASSEMBLY REGULATOR SMI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09346">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00860">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SMI1/KNR4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Knr4/Smi1-like" evidence="2">
        <location>
            <begin position="142"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI16967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="552" mass="60500" checksum="D14EA77992665F71" modified="2018-11-07" version="1">MESSGFGSALRSFWHTMTSYDRHSSYHSPHRSGRHVPLQNNRSGILTGVATARDSHTDVAYPYSDDGGRSSPPVRNGSYSPGMRSAAAKQTDGFEVQSPGDVPMQSFSDGLPPPPPVSHSWKRIDAWAEDNYPELFDQLCEGATTNDLNDLEHQLDCSLPQDVRQSLAIHDGQERGGNPSGIIFGSMLLDCEEIVQEWETWRKVNQQLLVDAANNAPPMTPSKLSAGSSEASSSRQQRPLSSSSASTADEWRQSLLARQDSVPPKAQRPLSSSSASTADEWRQSLLARQDSVPPKAVERAYAHLGWIPLVRDWGGNNLAVDLAPGPNGRWGQIILFGRDYDTKYVVARSWAAFLALVADDLNSGKWFVDDESGELKLREFKETRVEPAYFSILRWRMDQKHGRRAAKRASMAPPKTTTSPPVGSRSASPYASPTEVNGDARGRPVHRSSPLSSPMHAPPHLKPLPLSRVTEETSIPEMPSAEIEPSQLVEVNVMDDDDDEDDEDDVDTVMARGKNALRISTVVCPDADGMLSPKVNGKQPAMADGMLKTIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRU7</accession>
    <name>A0A367LRU7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_2591</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRU7"/>
    <dbReference type="STRING" id="1330021.A0A367LRU7"/>
    <dbReference type="OrthoDB" id="4927746at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017026733" evidence="2">
        <location>
            <begin position="21"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI17117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="217" mass="21669" checksum="849F7BC8FF30E7D4" modified="2018-11-07" version="1">MKSLSLIMAVAACLTGFVMAENQQGAEKQDLASADLLAGNEVLAATNTIALDSTATAGKDEPCGTSLASRLHDGAHCVLFFIPQGIFHPDDPQHFKKCCPWSRKKETSSSSSSSGSSGSSGSSGSSSNNFGFSSGSGSFNGGGFNGGGFNGGGFNGGGFNGGGFNGGGFNGGGFNGGGFNGGRNSFNFDFNGPGGPNGGGFVFRNGGGFQNFKKFQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRX3</accession>
    <name>A0A367LRX3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CHY-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_2811</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRX3"/>
    <dbReference type="STRING" id="1330021.A0A367LRX3"/>
    <dbReference type="OrthoDB" id="10253329at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008913">
        <property type="entry name" value="Znf_CHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037274">
        <property type="entry name" value="Znf_CHY_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05495">
        <property type="entry name" value="zf-CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161219">
        <property type="entry name" value="CHY zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51266">
        <property type="entry name" value="ZF_CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHY-type" evidence="6">
        <location>
            <begin position="590"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="171"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="343"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="171"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="385"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI17161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="662" mass="72835" checksum="5729382CFCB0284F" modified="2018-11-07" version="1">MIALKTNSDGSPRSRSQAVGEPSPSRIVPRPVTDSQAQDPRGYQLGQLRRRFSPEETADVDGGGDVELAFKLRPSDPDFPFELAYLDCRLRVPRCYPEERPQLRVANPHMPRGFAINIERGWDRLVGEREGATLLALVNALDRHLETFLSEQKADTVKLVNFNVTRHLQTKAQSTTDTTATATATTHGPPPTPKAEPKPSDGPGRSLVRETVYTKEQVAAAKQRRALEVRQLEARMGRLPGFRRSADGVVFTLPIEPKQRGELSSGLRSVCTLHLIVPLLYPLQHPRIQLNEADPVDAEPVEELFTQRAASQELLSLTGHINYLALNLSSLEKQARAASKAEAEAVKRVVPPRAASDEAPASDTRGPGAMKGSHVQVIPRPPEWTVDESGESSTDSSDDMTDEDEAEESIGMEGGTAREWPERGTLIQLPSVELHGIELLQIQSLSIRVKCDRCRTANEMTGLRPGLETTRSCSKCTAVLRAAFRPQLVHASSNRAGWVEVTGGKATELLPSTFAPTCSRCSTTSPGLVSVAGERVTNVCRECHGKFTLIVTEVRFLQPTAGTETETTSGTGAARRRAEAERLGLRVGEELPGRGACGHYRKSHRWFRFSCCGRVHACDRCHDEAEDHVNEWANRMICGWCSREQRYAVETCGFCGRYVVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LS65</accession>
    <name>A0A367LS65_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FMN hydroxy acid dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_2382</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LS65"/>
    <dbReference type="STRING" id="1330021.A0A367LS65"/>
    <dbReference type="OrthoDB" id="25826at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043168">
        <property type="term" value="F:anion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032553">
        <property type="term" value="F:ribonucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000029">
        <property type="entry name" value="L-lactate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF86">
        <property type="entry name" value="DEPENDENT DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G02720)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016819791" description="FMN hydroxy acid dehydrogenase domain-containing protein" evidence="5">
        <location>
            <begin position="21"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="6">
        <location>
            <begin position="71"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI17200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="449" mass="48448" checksum="2347222ACDFBE5A8" modified="2018-11-07" version="1">MARATLFLLTILLSTSLALAMGQGKNETTSFEKSFIVNRASTIGTLQPKNKTTPYAFYLKDLIAKGIQKGEPPVVTTDPNLLEETARKSMTERGFNYIRGSAGEGATMSANRLAFRQWKLVPRVLRPTTPRNLSVTLFGRTYDTPVIMAPIGVQAIYHPDKEIGTAEACAALHVPFTLSTAATTSIEDLHKAVPDGSKWFQLYWPESDDITASILKRAWDNKFEVLVVTLDTWTLGWRPRDIDTANNPFSVGIGDAVGFQDPVFRSKLNSTPEDDVISASQNWVAEAFPGRSHSWADLELLRKHWKGPIVLKGVLSAEDAKLAAEYKMDGIIVSTHGGRQLDGAVGSLDALPDVVEAVGDKITVMLDSGIRTGTDIIKALSLGAKAVLVGRPVVYGLGIDGAAGAHGVLAGILADLDLSMGFTGVKNVSELGRTTVRRVRDPAAYTSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LSR7</accession>
    <name>A0A367LSR7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LSR7"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI17449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="76" mass="8113" checksum="1CEF305EC47C7778" modified="2018-11-07" version="1" fragment="single">HIHVRQLSRPPLLSSPPFFSLPNIQHSTPTGSPPPPPPGPLSAESPLCIRTLARAFVSAPVPAIMLPNGSRQLDHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KYX1</accession>
    <name>A0A367KYX1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_3348</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000033">
        <property type="protein sequence ID" value="RCI07368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KYX1"/>
    <dbReference type="OrthoDB" id="4842715at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI07368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="157" mass="17096" checksum="5F054195A8EE1A9B" modified="2018-11-07" version="1">MLDITSAFNYLTTLIRSYLTSYSSRLKVDGRLSEPFDIKRGSELLYFIRAYIANISTLTLDSSVIVPTQEAYMLSSPKLSSLYSISTSPTALPAPSSSSRLIALQQAFEPRTPGSPSVSSPAIALASESPLLLGLRPGPLLLDSPPPPSRRRYPLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZM2</accession>
    <name>A0A367KZM2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA repair protein rad9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1679</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000026">
        <property type="protein sequence ID" value="RCI07618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZM2"/>
    <dbReference type="STRING" id="1330021.A0A367KZM2"/>
    <dbReference type="OrthoDB" id="60092at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071479">
        <property type="term" value="P:cellular response to ionizing radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007268">
        <property type="entry name" value="Rad9/Ddc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15237:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15237">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04139">
        <property type="entry name" value="Rad9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="375"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI07618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="543" mass="60567" checksum="5380F6B924E03CD9" modified="2018-11-07" version="1">MANLAKELKHLVEARNCPIYPSYFDSSFAPQQAPAPPNQSVNYLLCPKCPPWPAEPRLAFGPTITETAPRLTRIMPVLSFILSEDGVAAFREALICLSKFSDDVSLEARKDSQFVLTTLNNSKSAYASCRFATNKFFSRYQYHASEQFRERFHCRLYIRASAAALISLFRSRSSVDAQRDSEKQTLIERCDIAIEDGEGVKSRLNVRIIFRNGLTSTHQLPFEIVVPVHAKFNRQEAPHYWTISSRTLRQLMDHFGPGIEYLDINTDGDHVNFTCFSEKTVTEDAVLKKPLQTSIAVEVDEFDDIEVEDKLHIVISVKDFRAIIQHAGGTGNVLSARYSLPARPIQLTYTSDVMSCEFLIMTVGERGSNPDQKTKKGRKNAARHGAARLEATSRRTSVDPSETTGQKPSQVSRAGPPTASMMQQPSKPVPNIAPAKASASRMGAFDLRPSQKPPPPPTLQSESLFVEDEGWEPVRDEYEDGDEDARLEWDHSAEPNLTAVGVDRGVNDWSGRQESLQAAEAEPTCLEPTQRLSDVQSFALFPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZY9</accession>
    <name>A0A367KZY9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_5728</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000024">
        <property type="protein sequence ID" value="RCI07763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZY9"/>
    <dbReference type="STRING" id="1330021.A0A367KZY9"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000019">
        <property type="entry name" value="DNA excision repair protein ERCC-6-like 2 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029256">
        <property type="entry name" value="Heliccase-ass-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057931">
        <property type="entry name" value="RHH_ERCC6L2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25806">
        <property type="entry name" value="RHH_ERCC6L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14773">
        <property type="entry name" value="VIGSSK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="175"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="543"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI07763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="970" mass="109130" checksum="76328D38FC0F0D69" modified="2018-11-07" version="1">MKDADFRENEDATSEAEELFFSSRKRTAEVEDKVKWTDESDGPPAKVTRREPNRRSRRPRNISRIHGDGGQAGDNHVDLDRVPDYLRERRRVFDTKRRVHHEAALMLPPEYSDTSSDDFQRLGDLAERPQFPAATGIKPCRPYSDIELPQSGGLIPASVAQYLRDYQVSGVRFLHRKFVYQEGGILGDDMGLGKTVQVVAFLTAAFGKTGDERDAKRMREIRLHSGRWYPRVLIICPGSLIMNWKSELTRWGWWHVDVFHGPNKDDVLGTARSGLLEIMITTYDTYKNNRSVINMVEWDAIIADECHKLKDRYSNTTKALNEANTLCRIGLTGTAIQNKYEELWTLLDWTNPGHFGTRAEWSEAITKPLTVGQSHEATFAQLSLARQTANKLVHNLLPRYFLRRMKTLIAHQLPKKTDRVVFCPLTDLQRTAYENFLDSADLDVLRTISDVCAHGKKKGWCCQRFLPSGAPWQRIIFPSIIVLQKLANHLTLLAPSTTDLEAKQETELAVLQTCLPDTWRVLYEERDRIGSLVNPEFCGKWKVLKKLLKFWHGNGDKVLVFSHSVRLLRILQHLFTNTSYNVSYLDGSLSYEQRQDVVDTFNSDPTQFVFLISTKAGGVGLNITAANKVVIIDPHWNPSYDLQAQDRAYRIGQTRDVDVFRLISLGTVEEIVYARQVYKQQQANIGYTASSERRYFRGVQQDDARKGEIFGLANIFTFQGDASLLRDIVNQTNIAEAKAGVLLAGVDMEQAAKDEDLGTIKKEESTAADDKGLSQLAALLTAENQEKMLETHKAAAPKTDAVQAILTSAGVDYTHDNSEVVGSSKVEEQLSRRAAMTSYTAGDVEGQSTLFGDDDGGKVVYRPPEEVCLRQFCEMARTFGFAGATQFALVVESWSQEARTNCLDAFYRMRRAVACEAEAETVKAEAAVSVKAEATVSVKAEAAVSVKAEDTTKRTSIFLITDDDDDDDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L055</accession>
    <name>A0A367L055_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_5796</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000023">
        <property type="protein sequence ID" value="RCI07810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L055"/>
    <dbReference type="STRING" id="1330021.A0A367L055"/>
    <dbReference type="OrthoDB" id="1664597at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000008">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000027">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000034">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="168"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="21"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI07810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="391" mass="43943" checksum="D5E46BFAEDFC4708" modified="2018-11-07" version="1">MTPEEERRVALDSYRAKLIESREWEAKLKNLRLEIKELQKEFDRTEDNIKALQSVGQIIGEVLKQLDDERFIVKASSGPRYVVGCRSKVDKAKLKQGTRVALDMTTLTIMRMLPREVDPLVYNMSLEDPGQVSFAGIGGLNDQIRELREVIELPLKNPELFIRVGIKPPKGVLLYGPPGTGKTLLARAVASSLETNFLKVVSSAIVDKYIGESARLIREMFGYAKEHEPCIIFMDEIDAIGGRRFSEGTSADREIQRTLMELLNQLDGFDYLGKTKIIMATNRPDTLDPALLRAGRLDRKIEIPLPNEVGRLEILKIHAANVAVDGDLDFESVVKMSDGLNGADLRNVVTEAGLFAIKDYRDSINQDDFNKAVRKVAEAKKLEGKLEYRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0U2</accession>
    <name>A0A367L0U2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7849</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000022">
        <property type="protein sequence ID" value="RCI08053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0U2"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="523" mass="57892" checksum="14A848721C333138" modified="2018-11-07" version="1">MRWLDLTVFVWQPKEGEEERGKGRGGGGWLFWSGPIFSMYGPHLRRRCRALLSAFEKAAAPKISADYPIRKTSSSPWAGKQLVYPRGIFSGCQKRSMLTLILTCIFKAEDKRGGTESSPLPAFALLGDSGSKRRSRVTGYFLPHLVVPSIPMPAPVQHGAHRPRHRLIQHCLAASCFHPFFVFPIGPLTEHAAPKTGAGVLATRGRKEKRRNCACPSGQVLLEKSSKLPQPGSCMTGPNIRLSAPVAGPLEPEDGRGLMLELKSEKISSGVLVGSTNACTRSRWRHGRELHVNEAQPWQRQTKTDCSETFRKRTRSDSPAGMTDNLPTAPVTRAAVRRRKRLSSKDARTSQLAKPGKELKLNKSSPSVLSEGKKVPHGQSVLLSAIDERGRFHEVKRAVMRLHLVADLGASRRASRELKDSVPQARTMSQLTRVRRIKFCPRQMRCLTDVAIVNGFPQGRDAISRPVIVNDGVPLEILRALTLSRQTACYQHPSSRLRHRQPLISSAPPRAVAWRGPQKHDAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0V5</accession>
    <name>A0A367L0V5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Heat-labile enterotoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_7862</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000022">
        <property type="protein sequence ID" value="RCI08058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0V5"/>
    <dbReference type="STRING" id="1330021.A0A367L0V5"/>
    <dbReference type="OrthoDB" id="4925061at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.210.10">
        <property type="entry name" value="Heat-Labile Enterotoxin, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001144">
        <property type="entry name" value="Enterotoxin_A"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01375">
        <property type="entry name" value="Enterotoxin_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0800">Toxin</keyword>
    <keyword evidence="3" id="KW-0843">Virulence</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="399"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="695"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="800"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="347"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="706"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="818"/>
            <end position="828"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI08058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="894" mass="98727" checksum="1BC1224DC030CF2C" modified="2018-11-07" version="1">MAPLPSSTLGANSVFLPRAKSAHRFGITLLTKGSFWDRSLNARRHLHNEDESIHLYGLMAGINRPLSSARFIHLEFVTLSNRTPKMLIKWATTLTLSALLWLQWSGITDAGNCIGRLCGLNPQDALIRKGINPIALRHRVGTVYRVDQRKPAEIKALGGFRPRELDVNKASFSVWQHAEVSRKASGSIYVSTSERPAGAEVFAVNRPLSVARKHYKACYLWEIQATPNFIDVTATIGRDRLHVWEREILAAGGIRWDQVRGYTYLPDGRNTPIRKRVYVPNPDYNPMYDQFSYSGAQVDLAAVPANPKKDWYIDPNPERTRKAGLEFLDKSGRAVGLSSKQSIFSSAPAAPAGPAAPAAPAARADGPSRVVRRFPTKADDLLKNAAARGKSAYYKVAGRGNGNGQRPMTPVGAQPASSSSRGASIGKGVQRVQGKVNLMLVTLEAGRVFMSIKDFVRELGWGTYLKCTFQFNCPQTMRDYLRKLQEEQELAQREEADVRHRVWLNAHKFSAPRERHSMEYLLQRTRKLGLGPEHMPCNATARSCYHGYLPSETVELLETCLHGDQTVWLGWGCAFCDGSAEQPCASAEQREQAMTSATNLKATNLPLFDDIKCFKDDDLIDCAGGLTATEYYTAERNCLTSDNGDWHPEGAACLTRAAGASDEADNPLLPRYDFDFCTFGWDEKEAKCAELLPGADADEDEGESGMPPPPKKGPVPHPDDKVGQFMFAWTNDGCGTDTQSTCQKSPEELFTVFEPCSQQDFRWTCCGCVQGTTPPEEPSNDTEKGIPSDERWRLFFDPSSGNLEIRPISASEQPTPKPTTATATATGPTPRPHGKVGQFMSEWTEAGCGTDTQTRCQKRSEELMSAFDSCGQPGFRWTCCGCVPDPHFKQTSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0Y6</accession>
    <name>A0A367L0Y6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_6255</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0Y6"/>
    <dbReference type="STRING" id="1330021.A0A367L0Y6"/>
    <dbReference type="OrthoDB" id="4138492at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF11">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI08099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="57534" checksum="760084CD1D6A0559" modified="2018-11-07" version="1">MGILDSIDNGLAWLFGQWNGYSTGLMTALVVVISYRIMASREPDVHPLLLARQSVASAVRHEGESAVYRSQAAPHGLPLSSGLNVKEAGAPRWSRGRDGHLGDVWRRAASGGEDGAKGRILTVMGSEKVVEHGLEDVTRQINIIGRHIADHGGIRVAIYLPNSVELLAALLACSFQPNLTAILMPFNVSADELISMLRRSAVDTLVAAPGTFSLATVIQAYPSLRQLVWVLDAGNSHMDWSEGIDGSVNVATWQRLVKEGSDNGEVSAVTDDHSPQDVVMFWQGDMVRFTQANLVSGIAGQLAAIPARDKMGPWDLFLPVDSLTNVYTLVLTLAAVYSNASLALNSVAGPAVDLVLATKGIAPTVVVVGPETLAGLHKDSVVRVASGLGRLSHAMSTRTLAGQGVFAPANVLSVFSPRPAIGTTPGKLRLIYAADRAGTGMARLSSAMLSDVRIMTGARVVYALSAGRVAGAVSQTSLFDYRVDGGSHFGAPPTSVEVFFRDKGGYKTTDSAVEGEVMARGPCVSGAEASTGVVGRMRPDQTLSCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0Z7</accession>
    <name>A0A367L0Z7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MIF4G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_6278</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0Z7"/>
    <dbReference type="STRING" id="1330021.A0A367L0Z7"/>
    <dbReference type="OrthoDB" id="10252707at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005846">
        <property type="term" value="C:nuclear cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000035">
        <property type="entry name" value="snRNA cap binding complex subunit (Gcr3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027159">
        <property type="entry name" value="CBP80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015172">
        <property type="entry name" value="MIF4G-like_typ-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015174">
        <property type="entry name" value="MIF4G-like_typ-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12412">
        <property type="entry name" value="CAP BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12412:SF2">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09088">
        <property type="entry name" value="MIF4G_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09090">
        <property type="entry name" value="MIF4G_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G-like type 1" evidence="2">
        <location>
            <begin position="355"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="MIF4G-like type 2" evidence="3">
        <location>
            <begin position="562"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI08094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="805" mass="90182" checksum="BED48A9DC05803EA" modified="2018-11-07" version="1">MGDFDRRQGAGPHHNRKRRQRDTHADDDDHYDRRQQQRRRTDSAPVPVRLRRQLFALADSPLRQWGAEVQAVARMLHDNADDEQLCDTFVNLSMQLVVEQPLKAPFVAAVVLVLNTLKPDVVDVVLARLARDIDVSLGSGEWRQLKLLLKFLACLQPCLEGDGIFPLLDELFARAADLQTASSDDVGQPPPSEASLFKLLTPFHGLKTIGTEIVKIILLTIPYAVAAAPGKFQQKAADLMEKTDIIASEPHALQESVDPFHPEGRDASPTASSNLVMLLQKQLQAEAAKNWELACLPRPWQFALEDIEMQDKLAEAPKHALPAVNVPKTVVAGSRPLFPEVFFSVYADQDIESVPGPTNIAASLIRDGLVDTLNVLDFNRNAVARYLMDLDCYFAEGTFVKRATPFDELRNFPDDRATWKPEDVAVDTVFSQLFLLPKPECKVVYYHSVLTEACKLAPAAIAPSLGRAIRYLYRNSSRMDLELSHRFLDWFSHHLSNFGFTWKWAEWADDALLPDLHPRKWFLLGALDKEVRLSFAQRIRKTLPDAYQPLIGEDKDKDVPDFKFNDADTPFSAEGRELGALLKRKASDEDIQDVIDRVETQARERGLNPLVASTDVFMTTICWVGSKSLSHVLAYVDRTKGRLDDAGAASPAARTQIMTAVMSYWHAHPGVALSIVEKLLNYSILSPQTIIDWTLVSDGANGGRSLAQPHLLELVCNTMAKVSERVRHVLTVADATAEGCSQDIQAMRDLFRAIEDGLARWANKGQNVMDGGEEADMIRRWASRWLRIFRRMAAIEESYIEAAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2H4</accession>
    <name>A0A367L2H4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">DNA polymerase</fullName>
            <ecNumber evidence="22">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">L249_4847</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28 29">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21 30">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 22">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 22">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 22">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="22"/>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2H4"/>
    <dbReference type="STRING" id="1330021.A0A367L2H4"/>
    <dbReference type="OrthoDB" id="2414538at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05777">
        <property type="entry name" value="DNA_polB_delta_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05533">
        <property type="entry name" value="POLBc_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.60:FF:000001">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.690:FF:000001">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.342.10:FF:000009">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000004">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050240">
        <property type="entry name" value="DNA_pol_type-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056435">
        <property type="entry name" value="DPOD/Z_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025687">
        <property type="entry name" value="Znf-C4pol"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322">
        <property type="entry name" value="DNA POLYMERASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322:SF23">
        <property type="entry name" value="DNA POLYMERASE DELTA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24055">
        <property type="entry name" value="POL3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14260">
        <property type="entry name" value="zf-C4pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 22" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8 22" id="KW-0235">DNA replication</keyword>
    <keyword evidence="18 22" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="15 22" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="14" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16 22" id="KW-0408">Iron</keyword>
    <keyword evidence="17 22" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7 22" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="20 22" id="KW-0539">Nucleus</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 22" id="KW-0808">Transferase</keyword>
    <keyword evidence="13 22" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 22" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase delta/zeta catalytic subunit N-terminal" evidence="27">
        <location>
            <begin position="166"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="25">
        <location>
            <begin position="232"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="24">
        <location>
            <begin position="530"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="domain" description="C4-type zinc-finger of DNA polymerase delta" evidence="26">
        <location>
            <begin position="999"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="23">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="23">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF14260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF24055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="RCI08631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1098" mass="124256" checksum="E1D63D562211B537" modified="2018-11-07" version="1">MASAVLPQKRVLADAGSRNNIPVSPKRHKSDVFSSSPAARFPSSQRANPGSSQVKSAFESEVLEKLSQEMSDLRRSNAEKDQVWERPPCSGFAPERDPLCFQSIDAEEGTLHGGKATVKLFGVTQEGNSVLLHVTDFKHYLYVPAPPMFRAQDAKAYQTFLEGQIAQHQPAIHSISMCPRENIYGFNGNKKSPFLKVTVTDPKFIPKVRSTIESGSADWKGLWKAQEHGVMTYDNIQYVLRFMVDCQIQGMSWVEAPAAKYKLIPEQYRQSNCQIEAEVCFLDLIAHKPDAEWAKMAPLRILSFDIECAGRKGIFPEANHDPVIQIANVVTRYGDKKPFIRNVFCLDTTSPIVATQILDFAKEDKMLSAWQQFLLKVDPDIIIGYNISNFDFPYLLDRAKHLKVGGFEYWSRILNEKSRVRETNFSSKQIGNRDTKETNTNGRLQLDLLQLVQRDHHLRSYTLNSVCAHFLGEQKEDVHHTMITELFNGTPESRRRLALYCLKDAYLPQRLMDKLSCLENYTEMARVTGVPFNFLLSRGQQIKFVSQLFRKALEQKLVIPNFKSQKSDEQYEGATVIEPTRGYYDVPIATLDFASLYPSIIQAHNLCYTTLLDKKSIEPLGLVKDEDYIVTPNGDMFVTVKQRKGLLAQILEELLSARKQAKRELAQETDPFRKAVLNGRQLALKVSANSVYGLTGATTGKLPCLQIASSTTSFGRQMIERTKAEVEDRFRIANGYSHDAQVIYGDTDSVMVKFGTNELAEAMKLGEEAAQYVSAKFVKPIKLEFEKVYFPYLLINKKRYAGLYWTRTEKYDKMDTKGIETVRRDNCLMVQTVIERVLRMILIERDVQGAQDYVKETIADLLQNKMDMSKLVITKALTKDDYTAKQAHVELAQRMKKRDAGSAPGLGDRVAYVMVRGAAGAKNFEKSEDPIYVLENNVPIDTKYYLDNQMAKPLGRIFEPILGEAKARQLLTGDHTRTISVAAPTVGGLMRFAKKTQTCMGCKKPLTGKHESQGAVCADCGPRVGELYKRTLDRVSDLEVRFGRLWTQCQRCQGSMHCEVICSSKDCPIFYMRMKAKKDLEDAGKELSRFDADQAAMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2S6</accession>
    <name>A0A367L2S6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_4818</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2S6"/>
    <dbReference type="STRING" id="1330021.A0A367L2S6"/>
    <dbReference type="OrthoDB" id="5409589at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.20">
        <property type="entry name" value="Gas2-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003108">
        <property type="entry name" value="GAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036534">
        <property type="entry name" value="GAR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02187">
        <property type="entry name" value="GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143575">
        <property type="entry name" value="GAS2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51460">
        <property type="entry name" value="GAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GAR" evidence="5">
        <location>
            <begin position="572"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="294"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="391"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="732"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="830"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="294"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="761"/>
            <end position="772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI08707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="852" mass="91744" checksum="31AEF23A3665D4E1" modified="2018-11-07" version="1">MADQQPPARFRPHHVKRHSIFAASKDDLLARLAPPTAVEALSAPAGALSASLDAAPSPDRDLAMRAALFSRRVWEWLVELQAWTWPSTLDQAAFLNVGLSAAEAAQYANRVDQIGRDLDRLDVEEIKKHVLANHVLPLSRSTTPAADSDLSSLSSASSFIKMDDLTAVITTIVMQALPNLARLSSLLRLWIIRLRVLREVSPFLYALEHAETHLASAVAGDTTERKDVETTLAATVAEPARILDYMLDCLEGMPDTLPDVWIDRVEALERDYTDWAAARERNVLSAQAKHLSDGAAADDSAIASPGPGELRTTSWQADGPNDEFETGRGLRGNALDDGEAGGESLASTPESLSRVGTRHGEHHGSIVPPHCRLPMATVQGHGTLDELTAEDTWPMSSRAVEEDDDGSGLPPLRMSDSRQSLNSQASTLIFSGFGALSSSPPDMSTSPAVRLEDADLADDSPLHRRGKTGADDLLFLKSPADESFADDFDDIMSVMEDGTSYTLRSESGGDDDQQLQQQISNIIDAMPAAKIKLASEPVILNPPDLQLPRLRTAVSREGVCRSASNLSTVSSSRAATATPSFTLSPAKHCRPRHRRVHQEIKVYHLSRSTGEPPIKLFIRCVGEHGERVMVRVGGGWADLSEYLKAYASHHGRRSNKHASRVDICREVVSASTPTSHQSFFTSSPITRPGSAAAMTTTMTTTTTTTTKAAADDIVSPATPLQVRKMRALEAAYPMGGSRRRPWTPLGSGPASAPPTGETEPSSADSMRSSRSSWFEDEDDSSFLGLAGPSGRKVEMTDENRAWVESVKEKVRIASGSASLLPATAAVQGGRFGELGSVGSTRRLFPGGAGRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2U2</accession>
    <name>A0A367L2U2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4729</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367L2U2"/>
    <dbReference type="OrthoDB" id="3941926at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="565"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1115"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="323"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="662"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="684"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="727"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1115"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1156"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1176"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1220"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1247"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1276"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1297"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1320"/>
            <end position="1334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1422" mass="153783" checksum="5C162EBE0817F0E9" modified="2018-11-07" version="1">MAGNSGSHPKRHTSWKMSMDAPHTVLDASGYPRFTVTSQPAEHQVEFAQFYPNGLPVTYNMVHGYDSGGVPQEYMENHLPVRFYTHPPPNAVGKFSTLYGQFKQFGVLGELLPDRRVHLWNKDEIQSVCNSLRQVFWGDMKTLRRPTRWDDLWEYFDAVDLYHYGVLNIWNVMNTLFDENCIITSTWRTEVSVEIGHFTDEWMKEKENQDKLKAWDEMKGPVLCCLTSADWKKISNLQDGEIGLLKTALEYRRQTLLSGNVPQANKPAADLFTAYQTNNLTSWLADAQILGKNGLPPPPASAPYHGSQAGMNATAPCFVRSAARSGNRNSSNRGQRTPSSSAVEALHKSAAAATTTRRGGKTGDVVICMGSSRLPPGWDDKTSGESSSQKTAEEDLSQDSKPMAPSKPKTIENDSKPAAPEVLQEESKPKTSKSAAPKILEHGPKPRMLKKQSKSAPPRVSEQEPKSETLEKRSKPTTPKVLQQESTVNKDGKPVIASNKGKMESDAASDGKNNVRKDPVAPPSSRDALENIVVTVPEQTDVSRAEKDAARCVVTECRADAIADAAGVEGEGSDSQATDEASSQATTKVSGHPITASPESPASGNDQAEPGHDLSPISHDWPLTRPKQRDGRAQGHQQAQPKHEMVVSSPLDRSASHVRSRLGQSHNSWMQSQGRPNVAPRSGEATSLPTRPSAQLGGPHQRNYTAPSAGHRGPRVDSTGAAASPPRGGGGGGNWNGGRNGGKGRGGGRSYGQSRYEASHHSPQADFAHDNQTWKESSWRRQLNDSLSTQECRNENRNGNFAYRPCHCGRCNERNRSVWVVVHERPEVHPADVGARLRHGMGGRFGDVEAVIPTNSYDGIGFIVRFRNESSVPMALEFASGLIPEKQLSLAISAVYGSKWVNSTWQCPMPMAPDQGRMPPVNPGGAAGGGYPVLNLYGMHPIPDHAAQASPIYPVFHGPINPPVGMPAPPMGYNNNNHGNTSPVMMAPPPVACRPYHDDGHKNSAAPASISPVTILKPDRGNGTKATMDEVAQTKPPSEEALGGAVVAKPCSPLKETHEARVSLPASSPQKVAKEAEKDCIVQASGATVDEPVKDTKRENEVRAKAEEVIEVEETKVGETKAGESKYARDSNKQKLGKQATDQQKDDKPTTMTAGKDNEVQPKDEKQRVSSIFTEKQIEDRRRAWDRIPMPLNPQRAKKPVVLEATSKPTGPKAAEQKPASEASKAGDSDGGAARSVKGATTTTDKGNTRRQEGNAHHERGQSQETTTTGRETMGKKSKKKRNKSSRGTLPTMWGPQAGEAAQQQAAPSTPKADEKGPKTSTTTTTTTTTTTTTGSPSASAAAEDGGGKDKTPSRARQACRADAGGSLRQEKKRRGRAAAADDMDSSSNGSRLGPLHEAGNSLFNLLIYHSIERQEFLKPTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L335</accession>
    <name>A0A367L335_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_4849</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L335"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI08817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="101" mass="11321" checksum="1BC7EBB5E7973DBE" modified="2018-11-07" version="1">MKDWKHDLLTTYRSGNLSGTHLKETEKKTIQVAKDLTGYIGPLTDSNDSLSLGRSHAWWGSCIYIYVYVCTYIHAPPPPVSPATRAKVKGKISLLLRYILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3E1</accession>
    <name>A0A367L3E1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Altered inheritance of mitochondria protein 24, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_5078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AIM24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI08950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3E1"/>
    <dbReference type="STRING" id="1330021.A0A367L3E1"/>
    <dbReference type="OrthoDB" id="1705416at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="entry name" value="Mitochondrial biogenesis AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00266">
        <property type="entry name" value="TIGR00266 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31801">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 24, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31801:SF0">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 24, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="TRAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="186"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="260"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="275"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU363045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI08950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="522" mass="55059" checksum="4209060EFE253F41" modified="2018-11-07" version="1">MSGQQQFYPPPPDSAAAAQQQHYAPPPPPSRQYPSPPPCQNMNLPPSPLSQASPPAPSKAFPPPPQQQQQSFFNYPPPPPAAASHHTPSPRPQAPTSPPAPNSPPPTIQHHAPVPVRPMVGSETGHAYPPPSAVNYAPPPPPPPPPPAVSHHTPSPHPQPLSSAPVQVGQTYPQQAVNYPPPPPASLHSPSPAAPVFQQHAVQQHVVQPAASPEAGQMFPPPPPTTQQQQQHRYDAPPSQHRFDAPPPAFPPSPEAGYPAEKKSAASVTDEQHQIDTSNPANLQSGAPPASHFVGAGAVTDDVGTFNGGSYRISHRDTNSILTIQLAMGCPFDSKPGVMIAMSPTVTLRGQIKFSVKKVISGADVNMSKYIGPGELLLAPPMLGDITSIRLTGAETWIVGHDAYLASTQGVVKDHKRQGLGKAIFSGEGLWVYKISGTGILWVTSFGAIIRKDLVDGEKYLVDNGHLVAWNTKYVLERVASGGIISNMAAAEGLVCKFTGPGSVFIQTRSSKAYAGGQTVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3J6</accession>
    <name>A0A367L3J6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Ribosome biogenesis protein NOP53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_4949</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in ribosome biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the NOP53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI08999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3J6"/>
    <dbReference type="STRING" id="1330021.A0A367L3J6"/>
    <dbReference type="OrthoDB" id="5072at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011687">
        <property type="entry name" value="Nop53/GLTSCR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211">
        <property type="entry name" value="GLIOMA SUPPRESSOR CANDIDATE REGION GENE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211:SF7">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07767">
        <property type="entry name" value="Nop53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017302">
        <property type="entry name" value="Gltscr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="179"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="238"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="314"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="238"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="290"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI08999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="442" mass="49808" checksum="D8D27CEAC9171793" modified="2018-11-07" version="1">MPIIRGPQGESTSAPEQHGQPSRKGKKAWRKNVDVSEVEKGLQDLNEEIIRGGVIKEKPSSELFTIDVQGHAKSTRATRRRAKGTLKADEIIAQRSLVPAVSARKRPAERMTDGLVAPKRQRTDWVSHKELARLKSIADGHHESSIVIKDAQYDIWDTAATEPPVPKEADFIPQPQTAKVPKSMKRQPISLAASGKQLPAVRNPGGGHSYNPSFPDYEKRLLEEGSKAVEAEKARLAAEAADQEKQEAIARSAAEAEAAEARANLSEWDDDSEWEGIQSGAEDGRPSNKQPKRKTQAQRNRIKRRKEEEHLARNKAALKARRQQEQNLAALVEEVEDRERSKALIKAEFSGADSDDDEDDDDIPLRRKQLGKFRLPQPDLALVLPDELQESLRLLKPEGNLLKDRYRSMLVRGKVESRRRIPFKKQAKRKLTEKWTYKDFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3S8</accession>
    <name>A0A367L3S8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_5069</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI09086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3S8"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI09086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="245" mass="27928" checksum="8B50221FD458A055" modified="2018-11-07" version="1">MTDAKSSQDWASQVKTGSSDLPPLSTHRSQRFCHFLTGFLLLPNKAFFPQFSIRIASWIVLLLHWALLFFFPPSRTNSFIRKMYVYPSNAQIHVARCLDQLLRTYEWLDWALTPLLPPPAGHIHVMSSILQSSYSFQLLHPFLLKPGYEKPPPLPPIYQTKDREISSKPCGAGPVNSDPDSAPGSRGRPPPPPPANQTTSKAIVVWPLIYHPPGERRNTSPGIVSDSFFFFFFVFFFFFFFFAHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3V9</accession>
    <name>A0A367L3V9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_4967</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GPAT/DAPAT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI09109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3V9"/>
    <dbReference type="STRING" id="1330021.A0A367L3V9"/>
    <dbReference type="OrthoDB" id="10255570at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006072">
        <property type="term" value="P:glycerol-3-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07993">
        <property type="entry name" value="LPLAT_DHAPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022284">
        <property type="entry name" value="GPAT/DHAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045520">
        <property type="entry name" value="GPAT/DHAPAT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041728">
        <property type="entry name" value="GPAT/DHAPAT_LPLAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12563:SF17">
        <property type="entry name" value="DIHYDROXYACETONE PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12563">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19277">
        <property type="entry name" value="GPAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="7">
        <location>
            <begin position="212"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="801"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="803"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="820"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI09109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="829" mass="92641" checksum="8EA16785F2FDE322" modified="2018-11-07" version="1">MAKGDDSFDPANNSAPDLQILGDEITLQPSGFVEPQGPADDGREEALLNQFASFRAEPLQFLREVSLYVSGQGWRAYDRVVGQPVFYTGFTEHMKSAVLSAPLLQQRISDLAADRVAVEDKEGFFRNGKEDDGVKLRAQRRAVLESGLQEVAEKLTDDMICKMESKTFIRGAYYLVTQLLTRAYHQGIHVSSEEVLRLRKVADMAAKTKKSIIFLPSHRSHVDYVSLQLICYRLGLTLPVVVAGDNLNFPLVGSFLQHAGAMWIRRSFGDDALYTTLIQSYVDALLQEGYNFECFIEGGRSRTGKLLPPKFGILSFILDSLLSGRVDDAIICPVSTQYDKVIETEGYVTELLGMPKKKENLADFLSGGSSVLSLQLGRVDIRFHEPWSLRKFIDEQLSRLPLVPSGLVTEHDKPEVRAVREKLLRTLGYKVLGDINDVSVVMPTALIGTVLLTLRGRGVGKHELMRRVEWLTARIRAKGGRVAHFGNAPLSEIVDRGLEVLGKDLVGVVDGLAEPTYYAVDRFQLSFYRNMTIHLFIYEALVSVAMYTRVKRGGGSAMQDISHANLRAHVLFLSTLFRGEFIFSAAGLDANLDKTLRGLEADHVVRLDRDAGGNVTTVGLSSEERKAGRENYDFYCFLLWPFIEASWLAAVSLMGMAPPLGEEEGDVWLDQATAQDSAQLLGKTLYHQGDLSYFEAVNKETLKNSYTRFEQDQMILVVKSRDPKTPPRIQLDASWRPARDKTTGALVAEGKLWDFTEKIASARREGKNRRDGATVSSRVLRLTDQLGRRLFAEAAEAKVPSKLSREDRLALRQSVEEARRRRKPGRARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3W1</accession>
    <name>A0A367L3W1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI09111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3W1"/>
    <dbReference type="STRING" id="1330021.A0A367L3W1"/>
    <dbReference type="OrthoDB" id="5207784at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="298" mass="32775" checksum="6D35D30CF24C9DD4" modified="2018-11-07" version="1">MPSDPAVAPRTTTTTTSTSLISTHQHSLVRSMLTALAGSTRRNHHHPPQGQVARSIMSRRFGPGGIVDEPPAYSRGYHRPVIDPVVQPATLLAAGRFIYSDRSPAPPLALYELSHDADFLSDSNRQVGVDRLDHALKLHDGGAPQPSMRSKHIYDLRHPGAITGPTFPFHADPTSRQSLGSLGITTFRHKRWALAKGYRVHRATRGPHHRLLCGQVLFTAVPSKDKAVQFEWFDSQERLVARELADSGGVKSLLISAEMSMRNRDALVVAWTLKGWWDLSREGSSRMSHCEAGALVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L464</accession>
    <name>A0A367L464_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein eL8/eL30/eS12/Gadd45 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_1520</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L464"/>
    <dbReference type="STRING" id="1330021.A0A367L464"/>
    <dbReference type="OrthoDB" id="1928736at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000001">
        <property type="entry name" value="60S ribosomal protein L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039109">
        <property type="entry name" value="Ribosomal_eL30-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022991">
        <property type="entry name" value="Ribosomal_eL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002172">
        <property type="entry name" value="PRK01018.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11449">
        <property type="entry name" value="RIBOSOMAL PROTEIN L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00709">
        <property type="entry name" value="RIBOSOMAL_L30E_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00993">
        <property type="entry name" value="RIBOSOMAL_L30E_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="4">
        <location>
            <begin position="44"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI09210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="153" mass="16528" checksum="9595D296D0AA08BC" modified="2018-11-07" version="1" fragment="single">AIKVVKKSSCVHSDLDLTRLTKPYHQAPTVAMAPQKKSKKDANSINSKLALVMKSGKVTLGYKSTLKSLRSGKAKLIIIAGNTPPLRKSELEYYSMLSKAPIHHFSGNNRAPINMFPVTGNIELGTACGKLYRCSTLAILDAGDSDILSDQQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L486</accession>
    <name>A0A367L486_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_1578</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L486"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI09253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="149" mass="16795" checksum="0BE9A9CA0339B970" modified="2018-11-07" version="1" fragment="single">ARADEYFFFSSYLQHVMPVLVRVVVVFVFLAPQVFPYVAGNKRKKGGKGPDIGTWSSSSIFPEWTGFNSHGQNIGRQHCPARRLTWASELALRTISRRERKRALRPGPGEKWRKKGGGRGRSTDRGPMFGAAGRPVLCKRPRIRTARSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4U1</accession>
    <name>A0A367L4U1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_1393</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4U1"/>
    <dbReference type="STRING" id="1330021.A0A367L4U1"/>
    <dbReference type="OrthoDB" id="5290825at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000474">
        <property type="entry name" value="Sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF40">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="438"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="473"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="511"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="540"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="83"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI09232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="641" mass="71809" checksum="497EB1C882D11082" modified="2018-11-07" version="1">MAEVRPEPKAVRGEHLEEKAVSHTEEAQVRRNLEARIKNPLLGIPRQQLMRDVEAFAEYRGLQEHVQLLKKGALVAQNPNEAHAIDGPETLTQDELDALYVEKHHRWRLPMRLFLTIATCSIGAAVQGWDQTGSNGATIFFPRVYGLSPDNNNRHSLIVGLLNAGPYIGSSLVGCWLSDPLNNWLGRRGSALCRTWQQQMMCRLLMGIGMGTKASTVPIYAAENAPASIRGALVMSWQMWTAFGIMLGTAFNLAVFYIKDINWRLMLGAPFIPAVPLLLLIYLCPESPRWLMKKDRYRDAWKSMIVLRNHPLQVARDIFYISAQIEIEKELIGKTNYVTRFTQLFTIPRIRRANLAAFTVMIAQQMCGKVLDGRVSMNASDGGLCLGINIIAFYSTTIFVDAGLGNFKAMIGSFGFGLVNWLFAFPAFWSIDTFGRRSLLLFTFPQMFWTLLVAGLCTLMPKGTTTDPNNARTALVCLFVFLFGAFYSPGEGPVPFTYSAEVYPLSHRETGMGFAVATCLFWAAVLGTSFPFLLKQLHAVGAFGLYGGFNLVAFVMIFLWVPETMQRTLEELDDVFAVPVRTFAAYQIKETIPWVFKRYVFMQRHATRPPLYQFETVAAAAGETQAQAFATSSDDDKKTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4Y1</accession>
    <name>A0A367L4Y1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tyrosinase</fullName>
            <ecNumber evidence="3">1.14.18.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_3652</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2 L-dopa + O2 = 2 L-dopaquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:34287"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57504"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosine + O2 = L-dopaquinone + H2O</text>
            <dbReference type="Rhea" id="RHEA:18117"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:57924"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="EC" id="1.14.18.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tyrosinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.18.1" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000015">
        <property type="protein sequence ID" value="RCI09471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4Y1"/>
    <dbReference type="STRING" id="1330021.A0A367L4Y1"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004503">
        <property type="term" value="F:tyrosinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042438">
        <property type="term" value="P:melanin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041640">
        <property type="entry name" value="Tyrosinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF76">
        <property type="entry name" value="SHKT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18132">
        <property type="entry name" value="Tyrosinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-0470">Melanin biosynthesis</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016729086" description="tyrosinase" evidence="11">
        <location>
            <begin position="21"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="12">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="13">
        <location>
            <begin position="331"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI09471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="608" mass="67035" checksum="796464F02B5C881F" modified="2018-11-07" version="1">MLRNLAVVVLAPCCLTTSLALAVLPGYDFGLDVAHLTRRQDVATPIVVERLPLAPDGSIPLRLEIRQMRVDQHRWDLFVLSLSMLQTADQNDPLSWYQIAGIHGVPFQPWNGVLAAPGASESGYCTHSSVLFPMWHRPYMALFEQQMYKLANAIAAMFPNVTEKQLYQRAAADFRLPYWDWSISAPAGETHLPDVFWNPTVLQNGPNGMQNIKNPLFSYQFHPLDTEAFIWNPLKQWNETKRGPETSVSLTAPPSNNEKVNVALLSKLPEIQQRLFILFSNYHDFNSFSNKAWAVSKGLSMVDSIESVHDIIHLYGGSKGHLTYVPLSSFDPLFFLHHTMSDRLIAMWQVLNPSAWITPMAAGETTFTAIKGTMQTPDSPLTPFYASANGTFWTSNMARTTEAFGYGYADTSPWLVPPGGDVRLALIRKINDWYGPSSPVGLMMGQAMRAGVGNEANVDDGRYTEWLANVHVDAEALDGPVVIHFFLGEAPAEASGWETASNRAGTVGIFAMSHRTGSGRKISGSAPLTSALMGMVATGTLANVDPGAVTPWLRGRLQFRIVGADDEEVDPRDVGGLYIGISSSDVEVKKSDELPRWGPAVTRLELWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L559</accession>
    <name>A0A367L559_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_4043</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L559"/>
    <dbReference type="STRING" id="1330021.A0A367L559"/>
    <dbReference type="OrthoDB" id="10255539at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03273">
        <property type="entry name" value="ABC_SMC2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1060.20:FF:000005">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000278">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000385">
        <property type="entry name" value="Structural maintenance of chromosomes 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027120">
        <property type="entry name" value="Smc2_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="13">
        <location>
            <begin position="540"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="261"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="344"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="702"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="854"/>
            <end position="902"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI09560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1199" mass="134028" checksum="A575FEBDC0948ED8" modified="2018-11-07" version="1">MRVVEVIIDGFKSYAVRTVISGWDESFNSITGLNGSGKSNILDSICFVLGITNMSTVRAQNLQVNLSAGALKSNLDLTTSQDLIYKRGQAGVTKASVTIVFDNRDKKKSPIGFEEYATISVTRQIVLGGTSKYLINGHRAQQQTVQNLFQSVQLNINNPNFLIMQGRITKVLNMKAVEILAMIEEAAGTRMFEDRRDKALKTMAKKELKLQELRELLKDEIEPKLEKLRTEKRAFLDFQQTQNDLERLTRLVVAYDYVRCQEKLRQSAADLEGKKQRQKDLESSATRLRSEISHLEEDIGKVKAERDKELKKGGKAQALEDAVKKHANELVRLATVLDLKNTSLAEETEKKAAVEEAVSELEALLKVKTTAFENAQSTYNAAKEDLAKQSQDVESKEELLQTLQTGVASKNGQDNGYQGQLQEARNRATMAATEQEQAKIKISHLQSRLKEEEPRAKKAKEQNAGLLRDLDGMRSQAQKLQGELSKLGLEPGQGEDDVYKQESVLQERVRGLREDADKLKRQVANIDFNYADPVPDFDRSKVKGLVAQLFSLDEKHTRAGTALEICAGGRLYNVVVDTEVTGTQLLQRGKLRKRVTIIPLNKIAAFKASAQTVATAQNIAPGKVDLALSLVGYDDEVSAAMEYVFGNTLVCADAETAKRVTFDPSVRMRSITLEGDAYDPSGTLSGGSSPNSSGVLVTLQKLNSITRQLKETEKCLQEIQAKIARDKSKLDRARRMKQDLDLKTHEIKLAEDQISNNSSSSIIQEVEKMKATIIELRECIEAAKRRQTEANADVKQIEKDMKEFDTNKDAKLVELEKCLDKVRAKLDKDSAAVKTVQKDLQGAQLDVEQVGADLSAARDQLQEVEVGIRAQQRDVESLAKQQAEVNETHASVEAQLEEERAKLHLFDDELGALDEAIRSKNSRIAEDGLERQKLGHQMERFHKEQQAAADNVSRLESEHEWIGDEKDKFGRAGSAYDFQRQDIGECKATLRNLTERFQGMRKKINPKVMNMIDSVEKKEVSLKHMVKTVIRDKRKIEETIVSLDDYKKKALHKTWEKVNGDFGNIFSELLPGGSFAKLDPPEGKTISDGLEVKVCLGKVWKQSLTELSGGQRSLVALSLIMALLQFKPAPMYILDEVDAALDLSHTQNIGRLIKTRFKGSQFIVVSLKDGMFQNANRIFRTRFSEGTSMVQALTPADLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5H1</accession>
    <name>A0A367L5H1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_3985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5H1"/>
    <dbReference type="STRING" id="1330021.A0A367L5H1"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF5">
        <property type="entry name" value="BTB_POZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="20"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI09648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="292" mass="32567" checksum="89AE7CC06E61E2EE" modified="2018-11-07" version="1">MANNSALLALAELMKSGENSDLTFKCNGHDFKVHKLVVCGQSPVIKAALSPCFEEGRTNTINMNAFDHQTVGRLVRYLYTGDYDDSDGDSMKVDEEGDDSAVANSNSTPRYREPNVESLTIHIKVNSIGDYYGISKLMSLANVKLQNVFPPKGYRGIPCNIESPPWVLSLPNAVKLALESSGDVELLEILSAETANNISALVVTDDLKQMDDVSDFAFMVFKNCALEIQRHVRLNMALASQCTHNHRKIDELEKKVKEWESKDQLNNKTIEGLHERLIAPQKKRKTGNVTYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6K4</accession>
    <name>A0A367L6K4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6K4"/>
    <dbReference type="STRING" id="1330021.A0A367L6K4"/>
    <dbReference type="OrthoDB" id="5399183at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="524"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="445"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="567" mass="62069" checksum="CEB95A1FEAF2F613" modified="2018-11-07" version="1">MSRNIRQKLPPVASKRRRRSTSSSSPNLSDDDGYSAVEDISDDDDDDEEDVNAAEEKNIMTEAYKLPSATPRPQPEDEDAADEDEDENDADDDEDDDDDYGDDGGDNDFDASFDDATKRANGLEGFTFDLDTNPTHGESVEQRHVHFAVPSSDSDDTDSDDAQDDLFPDIFISQRYLDNTFRREIEGDADGSDGSGSSYWDFAGQYGDYENAVVDNSDDEAAAATLPLPMPSTVTDVATASEGVQGLDGYESDGDTTEDDVPEPLVCMRTRRPSNPSSEQSDGPDDVVTPIKGQRGKPRVGRFSLDRLDKKPIVVMNPQTRKMMIFTPLRRRTLDLSPEQFNLPYPVEPRRLFHDKGKVLTTMFSSNTFGDFVNAQNTSTADNSLPVQSDANTGCSDANTGCDSSVGEASASDGEENLDIDDFISWGEDGTSGEDGNRAGKWEPSSTAARRTTSSGNMDVLSHLNPDTVGAFRRNQIDQQLILSNQATRDSLVFSGPYNYTALRGIKSDRFDTAGLPLTPIRRQRKHVAEAGRSPLDSLSAKRKASGDVGAGHKRHRSISEVKMLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6T4</accession>
    <name>A0A367L6T4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_8436</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6T4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI10118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="70" mass="7796" checksum="724ABA88C7E2296A" modified="2018-11-07" version="1" fragment="single">VGKKGPNKVICIPSQRAKPGLITSKGYTSKELEAGEVFVLRRYFSRYFKVPTYSTLTYLYRCAQGGVGTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L754</accession>
    <name>A0A367L754_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_8527</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L754"/>
    <dbReference type="OrthoDB" id="10686540at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="493"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI10260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1004" mass="107098" checksum="F87DCEFD683F2AEF" modified="2018-11-07" version="1">MAEVRKPPRQPRPLRWVTGFPMDPLDEKKKKLMCGLTWLTMVKLTLKSVLRALIGMSVLKLPSFHLWPKAQGVRVPSGRFVIRTTGLSTPGTAAEAKTADQMTQSGLSIVGECGSAGTHETLRMRPGTSREPAASAGPVDRVEAGARPPPAGTPDRDGLLTGLDALGQGGDQQLLELVVGARAHQGGDEGAAAGAGDDVGEHVCVHQGTDDADVVVGARCTAGQTQGGAAVVCVDLPEERVLLFLGELPVQSLTLVDEVLHQVLGAVIRVAVQPRVVDADEVVLDAGLDQRLELVSNLGLLGRLPRALVVLGMRTQVAHLVPDRLDRLPVVVGERVLLPPALASEVAVEFLGGGDPFAVVGRPSHVLAELPLVAAQDEGLVRFDVRPRDEVADAQARQPGERVEEQGPLGDLVDDALARLVLGPLVVVDAALAVELVLARMGIRSGRRPGRGCDGRGVIRKVVDGDGEALGDGGRVDGRLDHRLRMLQRRRRLLLLLLLLLLLLLLLFVRGSRQVVGLGQGLGKSLEVIGMDPFGVDVGETRGLESLRREAVPKLWHPYGVDIQVALHIRLIRRVRHLQVQIPQQPSQDDDAHLHSVVDTEALPLPAPEPLPGTVRELGKGLAHHPLRLEGIGVLENGRVVVHLGQDDDHRLVVGNLVFPAAQENRALVLAVEGLDVEGRRRRGHPQRLEEDAFEVLELGQVSVLQLPAPTDDGVDLVAGLGQRLRVLQQVDERGGEQTRGRRAGALHGDDVVDALPVAETLAGLGILAGHDGREELLALLRMLLSPVQGGGAVLTHGVDNGLVLAPVPQPVHEPRPRPTQDRLDHEVLDGLDDGRLRASEAVEALAEEGLVDDFARQPPQAVKGRDRKAGALPLIHQLARQVVHGGEEASDGLGLQRRSQDSMSDAPDVLMVIGREEAVVDGRPDLDYRPAHVFAKALLIADLPGQLDAGDEDDGMAEDGQLEDLAVLLGQGLERLPGLVGVDVEDVAEQGHAVGLGDRLRHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7K0</accession>
    <name>A0A367L7K0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7K0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="96" mass="10861" checksum="877CA87DC17A8D6F" modified="2018-11-07" version="1">MARESLHDLIRSQDHGKVSGYRFLLPRNATHSLTNQREIFRRAQRGGSLSSALPYVCVIDVCRVAITISAATLPPRSNNAESTEMRRKRRNPRPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7M0</accession>
    <name>A0A367L7M0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7M0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="338" mass="37165" checksum="5490FBA36C46726D" modified="2018-11-07" version="1" fragment="single">TRPEGLGGSRDAGPAVASPRPSRLRLRRIAATAVRAVQAVRGKERRVKQGETDSGIRVRAKSSSYNSRRNSRYNSRYNRNNGSRRSYLRPYCTYAPYSRYLRPRIRCFLLLLFRHEARRPKIKDTIDWLEKHAFFYRKIGSSYGPGPVPGPGPGPNKSTEHSYGTRPEGLRGSRDAGPAVAGPRPPYVTEAEAATATAVRAVQAVRGKELAAAAAAAADLEGLFNYRLLRGGEDEGPALADLETFFLPIAGELTANSTLFFFDLCGRYGYGYSYSKRPRCYSSSTASSLPLERSLRPDFFGCFFCPLVFRPFLPSLFFLRPTEITGTGLGLGSGLGLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8S4</accession>
    <name>A0A367L8S4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fungal lipase-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_5242</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. Lipase family. Class 3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8S4"/>
    <dbReference type="STRING" id="1330021.A0A367L8S4"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051218">
        <property type="entry name" value="Sec_MonoDiacylglyc_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856:SF11">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016670812" description="Fungal lipase-type domain-containing protein" evidence="5">
        <location>
            <begin position="20"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Fungal lipase-type" evidence="6">
        <location>
            <begin position="95"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="305"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00043996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI10828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="352" mass="39760" checksum="D9C97B0BD832F4A4" modified="2018-11-07" version="1">MRVRLLTTTLTLLPGLAHGQDLDTGEQFTMFAQYSMAAYCPTLYDGFDRSDVCSNSLERSCANFDNTTTVTEFLNNDVYGVGGYVASNPNRRHVVVAFKGSDTMFDYITDASKKLVECDLCQGCLAHNGFYSALTRLKNHLRRAVQDELRKPGRQNYRVVVTGHSLGGALATLAGIYLRNVGIRCDIYTYGAPLVGNDALANHLSRQPGFTGRVTNGQDLVTAIPQSSWSPWWSYAHNYPEYWYDRRLEGETRQYELKKPRRCDRYNQCSSSKCFTWSRFLTFRGCSVTDHWQYGAGFDPCSTTTTTTTTTTTTPVQERKGKSGWGGLRERLGKRLFSLLPKVDKIYKMLMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L950</accession>
    <name>A0A367L950_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Nuclear condensin complex subunit 3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_5313</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CND3 (condensin subunit 3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L950"/>
    <dbReference type="STRING" id="1330021.A0A367L950"/>
    <dbReference type="OrthoDB" id="27187at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000793">
        <property type="term" value="C:condensed chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000363">
        <property type="entry name" value="Nuclear condensin complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027165">
        <property type="entry name" value="CND3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025977">
        <property type="entry name" value="Cnd3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418:SF5">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14418">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12719">
        <property type="entry name" value="Cnd3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear condensin complex subunit 3 C-terminal" evidence="9">
        <location>
            <begin position="636"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="570"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="979"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="570"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1005"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1033"/>
            <end position="1042"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI10948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1042" mass="116069" checksum="E2A2E4B350DB110A" modified="2018-11-07" version="1">MPPRASTRKPSAAASKKPAKAPAIEYHDRPNSRLRAQICAIFRDAQRTTATHRKLAINLRKVHEACCYEPKSRNKRSEDVDEDEEAFNHEFVRCVLRIMPVKKAEGVGERAIRFVGSFLRHADDKDLEALGEVDVEASLMPETPSTRLLSNLLEAVFPLMTAKDKFVRFRSTQLVSHVINSLDAIDDDLFQKLRHGLLKRIRDKEAMVRAQAVLGLGRIAGNQAEGCTDSEDSDGGDEEATDLLGKLLQVIQNDPSAEVRRSLLINLPILTHTLPRLLERARDLDPATRRAVYSRLLPALGDFRHLSLSMREKLLRWGLRDRDENVRKAAGRLFRDRWIADCAGTAEKDEHQEEAAAAAAAAAAEAAPSFEGLLELLERIDVVNSGVDNGIALEAMKDFWQGRPDYREAVTLDDAFWETLSAESVFMARSFNDYCLYEDDGRHAALVEEKMPEVTKLAFYLERYMQVLLETLQKDDDNQDDEDTVEQEFIVEQLLHIALTLDYSDEVGRRKMFTLLRQALSKSELPDEVTKLTVEALRCICAPDAAGEREFCSVVIESVADVHDTIVEADEEEGEDGDGEDKEEESFHSARSEVSGSEELKKEKKGKGNKRVRSDSQSSEDEAREKAVREIVVNLKCLHIVRCMLSHVSGNLKDKPDLVSTLNNLIVPAVRSHEAPVRERGLVCLGLCALLDRSLAEENLSLFIHFFTKGHAALQVTALHILTDILNVHGAQLLSATPALLKVYVKAVKGAKVPEVQAVAALATSKLLLGRVVAAEDACEELLKALVVAYFDPASASNQTVRQALNYFLPVFCYSRPANQQLMRAVALQALHYLLTLRQGLEDDDVDVDEDMVSMTTIGACLVDWTDPRKCYSSPPSVHQSDAADKKQPVNGDVHLDFARDILERLRTNISKEEKKLTASLLGKLHVSPGSSEDTVRQLYAQVSDAVNDGLLSDATSRNALYKLHVSLGKVVNGLDEQQPLDRRTSRSISVIPDRQPAEDKTIVEEPEIKEEEDEDEVDKTTAQVTRDSLLSDGEDVEMQDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9B5</accession>
    <name>A0A367L9B5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_5276</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI11021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9B5"/>
    <dbReference type="STRING" id="1330021.A0A367L9B5"/>
    <dbReference type="OrthoDB" id="19394at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.10">
        <property type="entry name" value="Bactericidal permeability-increasing protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027842">
        <property type="entry name" value="HAM1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045967">
        <property type="entry name" value="HAM1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138">
        <property type="entry name" value="CHROMOSOME 19, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31138:SF1">
        <property type="entry name" value="PDZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14613">
        <property type="entry name" value="HAM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19343">
        <property type="entry name" value="HAM1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HAM1-like N-terminal" evidence="3">
        <location>
            <begin position="3"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="HAM1-like C-terminal" evidence="2">
        <location>
            <begin position="624"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="774"/>
            <end position="832"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI11021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="832" mass="93619" checksum="84EDBD389C3A4956" modified="2018-11-07" version="1">MAPNVNRPTDPQEKEADINRKLQLYGIFSAFQLGKVPSNDQIDVALNSALASKALSEPDPKLSDDGKLLIKDTRDVIQKAQHLILSKNEGNLIQDFIWQTTQFDTKSIHGPDRPIDKDTVKRDGDETLKGMRTLGTLIITNGQFRKLLKDASVLLRDMAGDAASNAATFVRPSEDQLAQMDTAAPDNTWYDAPDMSKDKLKKRAQNMYSGTIKKDAKEVAEAGIDAATPAASSDPRAVNKTAGQNAVMSAAKHKIDENLDPETKEKIKKRNEEYRAKAKAYFEKKMPQERKDQLIFRLKKMILECQQHQDYSEAIQTLLRLAETYGRHGRSMGEGSAGSAKKARSGFSAAEADLRTLIERFANGTSTGELWSSIHQIYEAAEKDHELKGWFKSMNSYIRRCLLEQGYILEDSSSREWDRLYDHGRFLLRDKYRSQTDQVIGEVKFIGDQFDQDVHNKAFAQSVQKLFTHLGSDADGKSTFKPHLLKDFGELILPGLLMNINYIPIPRIEYVDPQFEAVVENLVLESDNFMPNVLEVVSNNFFRLGRKNLGNKNHNMIDVKVAGIQMDLRDINYYVKRKTGFPSISDTGIMDILLPGNGLSFRMKVSTADKKDRQNFFKVNKVDVDFKGLNIKLKKSHHKFLFALVKPLLLTILRPPIQKAVEKAIKDQCNKLDSEMYQIKLEADRAAQEGQTDAEKQENFYKRYYQAAQKRFTQAKDKEKEKVEKEAEDKKVNVAMTMEDSILPEVKLPSGVSTKATEYKELARKGEKWESPVFSIGSAKKSTDVPSAPRIEKKTRPPPRTTNGNSAAAAVNGKAPVTANANLPGQAHLSAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9D3</accession>
    <name>A0A367L9D3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9D3"/>
    <dbReference type="OrthoDB" id="4917153at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI10842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="332" mass="36951" checksum="6C3D4E00194B2979" modified="2018-11-07" version="1">MFSLPTSLLLTALFIIVCLLFPPFPVYKEVLLVRSPVLSSSASFTHHHFPIHQHLQHLQLFLPFILHTSLSSLVLTSSPSLVLGSIVLLAWQWPMLAFAKPVYPGDAPDLDILAGRNPVDVLYATGVWIGADDEPMCYINPRNVRGHVATGFSRVNRYDDEREEEHFTWSGAGKVEFRKRPALGQVSKCKDGERHFGWCGPGCVCCAGGHAGWIDDKPPREPVWGKSCDDPEKDSCHDIEGEESPPRVIGRFVGTEEDPYEITLDPVGQEAVRLLNTSQKVKDNDGAAWLGDHPLRFTMTGQEGAWRPEDNCFEGTMPIGANREGKRTHFIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9M0</accession>
    <name>A0A367L9M0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_7284</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9M0"/>
    <dbReference type="STRING" id="1330021.A0A367L9M0"/>
    <dbReference type="OrthoDB" id="20669at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991:SF12">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_8G05640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43991">
        <property type="entry name" value="WD REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_8G05640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="413"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI11123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="562" mass="60996" checksum="5C95D49369326352" modified="2018-11-07" version="1">MRPRSSSSAAAAAAAADDDGKDALDDSQPEADDDLDMSDSDGGADLIVAEHDYSTPVADLRVFVPDAAAAAAVADDVDDLAVPLNSFFSPSLIMNEFVIDQEAIQPDNFLPVQLSNPNPTILGSSNLGLVDFLRVWALNGCFPSASRSRPPHLLEVYAQARAQVEDVTYADLAADECDLQGLDWTTMETTREDARARRQLTYNNYVNRSGSDLSRGEHDPIPSSDSFFRFKRINFRSDMSLAHFQLRSVLACPTRKQAYYTSPSGISRLDLSSRRADLAMNLHDYFPTMGAVVSTLDAAHGVLMGGTFNGDYYIQPLDHDGLIEGQISPDAITNHLRIHTPRRSSRPVASIASNDCGFRVLDIETDTFVSHASYDFALNCSALSPDRRLRVLVGDNPSVLIVNADTGETLQELAGHRDYGFSCDWSDDGWTVATGFQDKAVKIWDARRWCDSSGNSLPVCTLRSEMAGVRGLRFSPLGGGRPVLVAAEEADFVNLVDAKTFATKQTVDVFSEIGGIAFANDGQDLNVLCCDTHRGGLLQLERCGDGTAGHRRPTLLAGPDPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9N3</accession>
    <name>A0A367L9N3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">TUG ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_7285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9N3"/>
    <dbReference type="STRING" id="1330021.A0A367L9N3"/>
    <dbReference type="OrthoDB" id="440781at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16105">
        <property type="entry name" value="Ubl_ASPSCR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021569">
        <property type="entry name" value="TUG-UBL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46467">
        <property type="entry name" value="TETHER CONTAINING UBX DOMAIN FOR GLUT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46467:SF1">
        <property type="entry name" value="TETHER CONTAINING UBX DOMAIN FOR GLUT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11470">
        <property type="entry name" value="TUG-UBL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TUG ubiquitin-like" evidence="2">
        <location>
            <begin position="11"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI11124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="501" mass="54543" checksum="CDFFFD430CADE3B2" modified="2018-11-07" version="1">MSAAAHVVVIAADLRRVTVKVSPGTCLIDVLDEGCTKLRLSSDKYLLRHKQKQVNLSLPFRNAGLITGAKLELVPKPYPPEVIQVALQLPDQEAKLLPDAAAGRLVGKFRSDTTLWAILHKFEQSVNGDGPRNIILTTRGGINAGAAKGQPGGQTYFEMPVFNVMGRELASLPVLLKTLSELGFNSGSVLMRLSFRTSEIVMDEAVRQLSDQTRTENEQLEGEEEKGRQIQQPEPEPDQPGNSYTSKDTQDVPHEQPDQSPSAAQKDASSPPARPPTEDVYRPVAVFLAPTSSTPAAALRSAADDDFTPTIAHAQLHQARLQQSSRNKRLPSDKEIAEQAAADVARIAAVKSVVVRVRFPDNTSSEWRLGPDHSAAFLYDAIRHVMANRQQPFRLILPGGKTAIYDVDDSLIRSYGLSGRVLINLVWDDKVPSDARKQPFLQPEVAHRGQELQAPEPDAVVEPNAKSAAAPVTSSVAKDEGEKKGDSGGSKIPKWLKLSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9W3</accession>
    <name>A0A367L9W3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">CRAL-TRIO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_7647</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9W3"/>
    <dbReference type="STRING" id="1330021.A0A367L9W3"/>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052578">
        <property type="entry name" value="PI_Transfer_CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824:SF29">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="7">
        <location>
            <begin position="115"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="818"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="950"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="832"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="842"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="871"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="959"/>
            <end position="980"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI11218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1049" mass="117878" checksum="FB4FC38351BEEAC5" modified="2018-11-07" version="1">MAKDGITQNGNALKTPLESPLPDCKPPTKTDLTAEEETKYSTLLSRAKEFAEVRCDKDKTKTGPVTADEQRWLTRQCLLRYLRATRWNVDEAGRRLLSTLAWRREYGIDGFTAEYISPEQETGKQMIAGFDRVGRPCLYLNPGRQNTDASPRQLHHLFYMMERVVDLMPAGVETLSLLINFKSTKQKQNTSVSVMTSREMLSILQNHYPERLGKALIINGRFQSLFVTDLSWVVGGFFKIITPFIDPVTREKLKFNEDMRQYVPAEQLWSSDWGGEMDFEYEHSTYWPALHDMCRRRSAERAARWEAAGSFVGESELYLAGGTDVSVEGFRYVNVDQVDVVEEKLAATRLEGSLSGVEDVEQRKTRRHQRHRRTKAAARRQGRCVALLSKYGNVRKRVAGSSRRADADDGADLLMVPYLTRLTATATAATQPLPSSSTAMAGVWTSMWPPRESFQQQAANMSSSPFPPGIMDSLLVSTSPLLQLAIFVYRQLGANLGLDPSVVLTFLGLLWALVRLGVRVYDLFRLVFDRYFTCAMYVSEDDHIYTQLMKWLAHQRTISTSRFLMAQTVWKSAWEDEDEHDDSLTWTSDTYLNFSNHAARSKPRYVPALGSSGFWHAGTYFHLNRKKENLFDNNIFTPMKSVEEIRISCSGRCIEPIKQLLADAKAFYYQDTYRKTTIYRPKPKGNRQEGSMWQQVARRPVRPMSTVVLDAAQKQAVMNDINEYLHPATPRWYASRGIPLRRGYLFHGPPGTGKTSFSFALAGVFGIDIYVISLQDVNVTEEDLATLFTRLPRRCIVLLEDIDTAGLRRDTVADVVANGVHKGKKQNSSSNAKKEDKRNDGSEAGSSSTGSESEDRTRRGKRRNAKKDGSSKGSSSSTADGISLSGLLNAIDGVASHEGRVLIMTTNTPESLDPALVRPGRVDVQVAFTNASGSQAAELFCRMYELSSSRRKSDTKGYDDDDDDDDDDDDDDDDDDDDGQLDVSGEKELEAVAAEFGRRMPDGQMSPAEIQGFLLKRKKSPRKALQDAEEWVEASVRQKASHSTVATVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LA11</accession>
    <name>A0A367LA11_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LA11"/>
    <dbReference type="OrthoDB" id="4083871at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42077">
        <property type="entry name" value="YALI0F30239P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42077:SF1">
        <property type="entry name" value="YALI0F30239P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="93" mass="10275" checksum="2160A5E8BA635E99" modified="2018-11-07" version="1">MAQGTSAIGKVFPLVIALVVLSVIGWVLHQVYLSASKFRDSASERMGKKNVVFTKDGVRVGVKHMQNEKYVDNTQSWVVKAWNLSGAQDNPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAG0</accession>
    <name>A0A367LAG0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAG0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="170" mass="18628" checksum="1F7D4699B104BEC5" modified="2018-11-07" version="1">MRFIPFSPKNNTDVCGAPEDVPVAYYFNGVMPGSSDMAGTFSTAAIPPAEEEGEGGGGVEVEYLDVERRGRGGEEGRGERREGGVLPPERLVLRQSWLMPLHGDTQFWSLYSVKPLGVFCRKKEQFWHSRFKFGRIRTDGGFEHSHCGECVRGSGRQSTKAGGGGRRGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAH4</accession>
    <name>A0A367LAH4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hpc2-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_7544</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAH4"/>
    <dbReference type="STRING" id="1330021.A0A367LAH4"/>
    <dbReference type="OrthoDB" id="5576775at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014840">
        <property type="entry name" value="HRD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125:SF12">
        <property type="entry name" value="AT HOOK TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125">
        <property type="entry name" value="LP07818P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08729">
        <property type="entry name" value="HUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hpc2-related" evidence="2">
        <location>
            <begin position="513"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="580"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="629"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="645"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI11414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="669" mass="70764" checksum="EA6E0D355B29CFB6" modified="2018-11-07" version="1">MATAAVSSRYESSTGELSSPPSGSLSEPTSPSGPKSMDQAEIVVGSDQPHPPSQPSQPPGQITFQQYPAGQRPAKKYELINGQLVQLTAAGVPRKKPGRKPGTMVKPKDATSSSEPPKSRKPRKPKESSSTTTSATTAPSSGTNAAAPPIPRKRKLAPVSDLDTDADAPRPTAPSASLPSQMTQHHHQRPGYSRDASYPGSMQNILNADPPASSSTVPVRSIYDPIRGNYDPVRETITAFQPPPPTASPRAPTQLAHRSPSIASLLEPQAAAASPSSQTHHLSASQSRLQQQQQNDSPSSMPTSPSYRQASNPGPTKKEAAIPDGSKDTPPPPAPPPPSLPPPPPTSSSQPAVQQRPVVNQAKFTTISSGPIRKVDKSHTGVSTPKTDNAEDPCHESEGRSILDFGKAKPGEELQVPTIILNVPLKMGETNKYVNFMRMAEERYGWDALHPRLAANRERKARIAAAAASLEKVDSSRESGDEMSVDLSDAEASNQENGGTSGPDAQAKPKKKRTLKEDKYDVDDDFVDDSELLWEAQAAASRDGFFVYSGPLVPEVERPPAGYTKPPPFAPYFVLLTAPCHNSVDGQPKRGRGSRGGRGGRGAARGAGAGRGGGPGSRGGAAPRKPRATKSEKLQRDREKAELSKTPTATNPYALQPTTPSFTVSELGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAI2</accession>
    <name>A0A367LAI2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Jacalin-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_7521</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAI2"/>
    <dbReference type="OrthoDB" id="74460at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.30">
        <property type="entry name" value="Jacalin-like lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001229">
        <property type="entry name" value="Jacalin-like_lectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036404">
        <property type="entry name" value="Jacalin-like_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053002">
        <property type="entry name" value="Metalloproteinase_M10B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021917">
        <property type="entry name" value="Unchr_Zn-peptidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21054:SF2">
        <property type="entry name" value="MIP04191P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21054">
        <property type="entry name" value="ZINC METALLOPROTEINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12044">
        <property type="entry name" value="Metallopep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51101">
        <property type="entry name" value="Mannose-binding lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51752">
        <property type="entry name" value="JACALIN_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Jacalin-type lectin" evidence="2">
        <location>
            <begin position="626"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI11429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="772" mass="83788" checksum="1E143E930D038A8F" modified="2018-11-07" version="1">MAPKFLSLRELRRRSKASFRTDNSTDGSSDGAVSQGTSPSSGSVTPPSIALQSDTALDMQIKNSPNPQGQPLPPRPVLGSKLNGSRHSVSGMSGLGSPSLSGKNSLPLSKYAPRVHNVTENSWAYQKVLLVNGSIGEPGLPPIDGTIVVSKYDDSFPPVSWPVCESNFKVLLYLQPGPNKFRLDFSSPKLANSTSSNPIHASFLTLHMLPTLNAPPLQLAILVGRDSPGVFDAVPARAEREGNGLEVAINKFRMAAYLWQAFTAEQMWRHKLGRRVFRFEEEWTVGTANLRDRETGTMRSEARIHVIRSDKTVAELRHLDRAQQNERGTDRDALFGIAAEAVKRHFKPLPGQKNYVSVLLLDAHWDTKTKTITGHAALGGNSGDLQLAIFGSHCLQSYPSCFEEVVPAFTDCTPTDLSCVANDCNDAGSSWEAANIGIGAHLHETGHLLGCPHQESGIMLRDYVVFNRSFVPREAYSTRTKSKGGLALQGDECGWHRLDALRFRSHPAFRLPSDPPPVPNDSVQAFPAEGSGVTVMAPSGISFVEIYGETDGVCGAWIEFPRDSGPLQRQMALHEQDLRSRLPEDKRKGRVKISIMSHGGGSLTIEDVKAFASKASCVKMGGGRTAWRSQKVGESKMAGSQDQDVVFTSATRQDRVMSRIIIYHGSALDGVEFVYDDDSTQLFGKKGGKKGGDVVEFGNRRRGEYLSGFIVRAGLWVDGLQVMTSLGRKSAMFGNAHGGSAHTLIPPRGYAICGVSGSCGSWVDGFSLLIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAM6</accession>
    <name>A0A367LAM6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Potassium transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_7192</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TrkH potassium transport family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAM6"/>
    <dbReference type="STRING" id="1330021.A0A367LAM6"/>
    <dbReference type="OrthoDB" id="9999863at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140107">
        <property type="term" value="F:high-affinity potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004773">
        <property type="entry name" value="K/Na_transp_Trk1/HKT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015958">
        <property type="entry name" value="Trk1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051143">
        <property type="entry name" value="TrkH_K-transport"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00934">
        <property type="entry name" value="2a38euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064:SF30">
        <property type="entry name" value="HIGH-AFFINITY POTASSIUM TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064">
        <property type="entry name" value="POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002450">
        <property type="entry name" value="K+_transpter_TRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="4 10" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="460"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="532"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="595"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="656"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="715"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="744"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="154"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="814"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="179"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="251"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="349"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="821"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR002450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI11466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="936" mass="104330" checksum="BE695D5831785E72" modified="2018-11-07" version="1">MFEATQEYVWTQLKAVKPAFVSKKPHFNFITVHYFWIIGATIIASIAIFASGGGKLSYIDALMFGSGANTQAGLNPVDLNTLNGFQQAMIYLFSMVSNPVTLNACVVFLRLYWFEKRFQSWVREIRSRRPTFAKTRSKSVADVELANARPQGVNGRHITIVPQDGRSQRITNDGILLDSQRDVSPRTTERVKSDGSDSTAVTDDKQITTEADTPRPFGGGGAHENTDAQPEEGARSGPAGNLSISFANKVKRSDGMGEESLKTTHHRPNAEHIAILERQRNQDNEVLRIPGPRDAERGLGPRRLQDDDPQDEDDNALAKTRSADSQTDQTAPDPTRIRDRHPTITIAEPNRRTERVKENARAIGGTLETLRLRKPPQPRAGRTSHRQGAGDEGRAPRSRSASGIRRLSGIRTALSLSREPEMMPYLSYTPTLARNSNFVGLTIEQREELGGIEYRSLRTLAFILMLYFWGFQLLILSCLWPFILHNAFYGKVVENAHVNKTWWAFFTSNAAFMDVGFTLTPDSMISFQTSEFVLMIMWFFIIIGNTGFPVMLRFLIWVAAKLAPRGSGLWEELRFLLDHPRRCFTLLFPSGPTWWLFWILIILNAIDLLFFIVLDLGGEPIDKLPLRNRVVIGIFQAASTRTAGFTAVNLSELHPAMPVLYMIMMYISVFPIAISIRRTNVYEERSLGVYHEHDIADDADSSALSYVGSHLRRQLSFDLWYVFLGFFILAITEGGKIQAHKFDLFAVLFEVVSAYGTVGLSLGVTNASLSSQFSVVGKLVIIAMQIRGRHRGLPYGLDRAVLLPSESRFRKEAEAADADCTNANNVSNATTTTGLQRQRTNPGARRSMSRERANSNLISQFLHPGPVVHRDTDLPHPRPRSMDSCSPSLASPSVFAASLGPRTQTEPVGETGVDEVTTPSTPSSHHKPTRSETSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAV3</accession>
    <name>A0A367LAV3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_7560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAV3"/>
    <dbReference type="OrthoDB" id="414945at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI11558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="70" mass="7775" checksum="1C106D4F6E7227AA" modified="2018-11-07" version="1">MRLFQCLATRASIAGFVIFLAGGPIAWKSKQNEPSLDEDERTGGESVYPSLIRQERQHTRGLGPKTSLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAV5</accession>
    <name>A0A367LAV5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_7565</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAV5"/>
    <dbReference type="STRING" id="1330021.A0A367LAV5"/>
    <dbReference type="OrthoDB" id="341511at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.770">
        <property type="entry name" value="RecQ-mediated genome instability protein Rmi1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049363">
        <property type="entry name" value="RMI1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042470">
        <property type="entry name" value="RMI1_N_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013894">
        <property type="entry name" value="RMI1_OB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21521">
        <property type="entry name" value="AMUN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21521:SF0">
        <property type="entry name" value="AMUN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08585">
        <property type="entry name" value="RMI1_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21000">
        <property type="entry name" value="RMI1_N_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RMI1 N-terminal" evidence="3">
        <location>
            <begin position="304"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="RecQ mediated genome instability protein 1 OB-fold" evidence="2">
        <location>
            <begin position="363"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="264"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI11560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="530" mass="57665" checksum="AC66135B592F01AC" modified="2018-11-07" version="1">MASPKLKAEKISRPDFDALLAQYPTLLQATSKAKAGTPSRRAETDDDKRKKSLAELDEYRYVKAPSIFGPESRLREMLLEDVKLLVEWKLLMQGGGKSRHGTFRPKLLSLVSSNAASTVQKTIQEAIATTSSSSSPTTTALTKLTSLKGIGPATASLLLSVHDPSRYIFFSDEAFRWLCRGGDAGAPIRYTVAEYRALDEAAASVARRLGVEAVELEKVAYVLMRRGEGHDLSAKGHQREPSPVNEVRRSKRLKRTKKKHQDQPTTPIFTTAAATTATTTNLSSSSSFPASKWISSPSSEPPSSQAPSPPPPTTFLTTLITSRSPPPPFRSLLATAKARLLASDLTSSSPSLFDPSLLSALPPDATSATAASVRLTRDTHVQVLDVEDLSLSRWEQAEALREVARGERTSGRQIVRVEESVDGGDADEAQQQRPAANEPSRRHDNATHRLVLQDCRGTRVYAVELRRLPRIGVRSTAVGEKILLRAGTVVARGTVLLAPESCLLLGGRVDAWHDVWASSRLQRLEEAADN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAV7</accession>
    <name>A0A367LAV7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-splicing factor PRP46</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Pre-mRNA-processing protein 46</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_7347</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6 8">Involved in pre-mRNA splicing and required for cell cycle progression at G2/M.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 8">Belongs to the WD repeat PRL1/PRL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAV7"/>
    <dbReference type="STRING" id="1330021.A0A367LAV7"/>
    <dbReference type="OrthoDB" id="10256122at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000012">
        <property type="entry name" value="Putative pleiotropic regulator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045241">
        <property type="entry name" value="Prp46/PLRG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923:SF0">
        <property type="entry name" value="PLEIOTROPIC REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923">
        <property type="entry name" value="WD40 REPEAT PROTEINPRL1/PRL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="1 7 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="152"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="194"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="236"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="278"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="361"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU369036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI11551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="465" mass="50479" checksum="0F1235D8C10BD8AC" modified="2018-11-07" version="1">METQQLPSDVAQLGALASRNAIASRKLYTRVAAGQPNAKRAKLSPDESVEDDLMKRKFSAEYAASQTLPPSLAAKQPIKKPGKALVKATKPLTGGKQQALLEGGGAVGSATGASGGSTTSNGTSLSLTTRAAQSYHQQKPEWHPPWKLMRVISGHLGWVRSLAVEPDNKWFASGAGDRTIKLWDLAQGTLLLTLTGHISTVRGLAISPRHPYLFSCGEDKMVKCWDLETNKVIRHYHGHLSGVYSLSLHPTLDILVTGGRDGVARVWDMRTRSNIHVLSGHTQTVTDVKCQEADPQVITGSLDSTVRLWDLAAGKTMGVLTHHKKGVRSLAVHPSEFTFASASTGSIKQWKCPEGAFMQNFEGQNSIINTLSVNQNNVFFSGGDNGSMSFWDWKSGYRFQALDTTAQPGSLDAESGIMSSTFDRSGLRLICGEADKTIKIWKPDDTATAESHPIQWTPSMARRKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBB8</accession>
    <name>A0A367LBB8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBB8"/>
    <dbReference type="OrthoDB" id="5210591at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="556" mass="61570" checksum="3D6DADB12FCB1D02" modified="2018-11-07" version="1">MRANGPMLDIHMSVRGPRAPPPFTLPPMARACHDLRHALSQLTSSFRYSLRDSRTSLSMGQTLRDRSLLTGRCPLLMLSYLHHHGPPSDPIIIGAAAMADKSPSSHLHGLIKSAASKFTAADFHQLPSAKPQTKFFATTSDAETLLLSLAPRATALLRCERSLILSEAALLRWLAGVGDESRPTNDTHLLRQPGLMTARRDMDRRRVPDTEPQPLRSYLPSLLEHGPAWNGRHGEYILTIPVAGMTVASLAPPLSMAERKCVDFQIGQLLRRMSSLQSPNGKFGTAVAVLSPAPTVSDVHWGRTITSDLNSCHDQWSDAFLCMLESALRDAEDFRVAIRYEAVRDHVGRFRHFLDAVTHPCLVAIDAGEDAITLVSTLPDIHHQDDRRSLSDSESRKQLNDSAHGQSSLDTRGATRLKARPARASIRVTGIQEWSNCVFGDPLFASVLSRNVSPEIWNGFKSPLQGHGVGEPLDDMASARIRRLLYECHHAVTTIVREYCRRRSDSDDRELPARKRLTQVLRILDGLDDFGRERRPHPSGDTSPAKRTKSLDGSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBN6</accession>
    <name>A0A367LBN6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Kynurenine formamidase</fullName>
            <shortName evidence="3">KFA</shortName>
            <shortName evidence="3">KFase</shortName>
            <ecNumber evidence="3">3.5.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Arylformamidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">N-formylkynurenine formamidase</fullName>
            <shortName evidence="3">FKF</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_7553</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>N-formyl-L-kynurenine + H2O = L-kynurenine + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13009"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57959"/>
            <dbReference type="ChEBI" id="CHEBI:58629"/>
            <dbReference type="EC" id="3.5.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid degradation; L-tryptophan degradation via kynurenine pathway; L-kynurenine from L-tryptophan: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="domain">
        <text evidence="3">The main chain amide nitrogen atoms of the second glycine and its adjacent residue in the HGGXW motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the kynurenine formamidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.9" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBN6"/>
    <dbReference type="STRING" id="1330021.A0A367LBN6"/>
    <dbReference type="OrthoDB" id="420264at2759"/>
    <dbReference type="UniPathway" id="UPA00333">
        <property type="reaction ID" value="UER00454"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034354">
        <property type="term" value="P:'de novo' NAD+ biosynthetic process from L-tryptophan"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03014">
        <property type="entry name" value="KFase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049492">
        <property type="entry name" value="BD-FAE-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027519">
        <property type="entry name" value="KFase_ver/fungi-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF33">
        <property type="entry name" value="KYNURENINE FORMAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20434">
        <property type="entry name" value="BD-FAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2 3" id="KW-0823">Tryptophan catabolism</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017008245" description="Kynurenine formamidase" evidence="4">
        <location>
            <begin position="26"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="BD-FAE-like" evidence="5">
        <location>
            <begin position="49"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="HGGXW" evidence="3">
        <location>
            <begin position="61"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI11839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="296" mass="32655" checksum="C1892A4368CBF1FA" modified="2018-11-07" version="1">MKTRLFPTRLLLLLLLLLTPSLTEASFQLLSYGPHPRHVVGLWKDDDQASSSSSPWIIYIHGGAWRRQQDSWQDFHPSVNNMISSRLFPPGTTFASIDYRLSPCAYPGANPCPFPIQHPDHIMDVRAALQMLSQQHGLQENSYVLVGHSAGATLSFQLLMGEAALQGQPLIYAPLPIAVIGIAGIYDMSAINDRFRGAYSDFLTMAFGTDLSLWHRASPARFMGSFRHSLPPSGTVLLARSPQDSLVDEPELDTMARKLEADGVAFSVVKTLRGEHNSVWADGDQITALVTSVFPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LC65</accession>
    <name>A0A367LC65_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LC65"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="348" mass="39384" checksum="62EFE864FCF66722" modified="2018-11-07" version="1">MSAQLKAKVMEKLALERRRMEEWFKSLPKPVYDPIDQGWVSNRDSFPELFSEDGYASNTSAASRMVIVTKGRPSFPPPPSVAAGGTARCLYDSETDESDGSLEPPSMPSPRMEKGKAICSPWSLRFSDCDEMEAGDDSSLYTSSTEATPASRRNPNSPRLNEERPEPETGQEGDGPSPMTLEDDSLFGYEAELRYWRRITMPVRYVLYMVLALVRLCNWLSHMVKMLGSRCSTGDEDGDESQRECEPVSVTACSKNQPPWVFQRGMEYESSLGSGPDDSEWDGREWEESVIQRASTLKLEIDASPPAAHTYYENHHFTFRGLRLLLAQSARVLELVRYYRQHQLTKHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LC91</accession>
    <name>A0A367LC91_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_0536</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LC91"/>
    <dbReference type="STRING" id="1330021.A0A367LC91"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF7">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016586768" description="Cytochrome P450" evidence="11">
        <location>
            <begin position="23"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="519"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI12034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="544" mass="62382" checksum="07E15943EFB49FD0" modified="2018-11-07" version="1">MTSNSVIPALLVLLCLVVYHEYQRRRERSRLPPGPKGLPIVGNIRDLPPRGKPEYVHWMKLMQRFGPVTSVTVLGQTAVIIHDRQATNAILEKSSKRSSGRPDLQFAHRLCGFEGMVSAMQFDHDLIKQRRMMHQQMGTKSSMMRHHKTMEREAKTLVLRTLREPEKLLQHFKVVMGAIILKVLYGYTIDQQEDDRLVRLIGLMMDDFGPAFAALTWAVDLVPALRHLPSWMPGMGFKRKAARTKRLVGAVVNIPYSKGEQEDEMLAADDVDAIKYSAANLFAGGADTSSSSLSSFVLAMTMYPDVQRKAQKEIDDVVGRDRLPRFDDRRNLPYVEAVVMEAHRWMPVAPLATAHRTSEDIIYNDYLIPNGAQIIPSAWWLTHDPQTYRDPDEFDPDRYGPRRDEPDPRSIIFGFGRRRCPGQMFGDDGLYLLLVHVLSLFDIGKGLDDEGGEMEPVVEASPGLISYPVNVRYSVRPREGKEHLLRAIEAENPWQESDARFVREEIDLVLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCB1</accession>
    <name>A0A367LCB1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1054</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCB1"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="90" mass="9328" checksum="58D9917FEACC55EB" modified="2018-11-07" version="1" fragment="single">TWPEGLGGLHNAGSATADPRPPYVIEAIRYSGCTRPEGLGGSRDAGSATADPRPPYEQHNNVGGGYGYGTATPYSGYGRTGRTGRTREGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCE2</accession>
    <name>A0A367LCE2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_0083</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCE2"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI12086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="40099" checksum="BB4669CDE8DD5D24" modified="2018-11-07" version="1">MENRMIARYETTAAYSHPEAKVDIVLVHGLNGSPQKTWTASNGVFWPLDLLPASLRGAPANVLTYGFNADVYSRRHNGGGSASDNFIHQHAQTLVTSLTLFRKGEGTSRNAIIWVCHSLGGILVKRALLYSNDVRTLHHEDYRSIYVSTFGIFFLGTPHTGSDVATWGLVLQGMADAVVPRKLFESESVLLKTLKRDSETLSNINNHFLDIYQRFRIHMAHENHKTDIKGSKIIVVDANSASPQLPGITYYGVETTHAQMCKFSSASAPGYRALSTDIRQWVLDAPSLIAVRWEAEEQERAARVRNEMHERMFPTASSWAHDVAARDSLLLERGRITSCSKQLTPELEMLMSTTTQHGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCF1</accession>
    <name>A0A367LCF1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_0882</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCF1"/>
    <dbReference type="STRING" id="1330021.A0A367LCF1"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12365">
        <property type="entry name" value="RRM_RNPS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034201">
        <property type="entry name" value="RNPS1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF62">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="71"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="5">
        <location>
            <begin position="416"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="155"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="328"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="42"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="240"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="278"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI12096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="769" mass="85200" checksum="6B8A0154E591C658" modified="2018-11-07" version="1">MASRYRSLTRSPSPPPPDVRSSGRRRRVDSPSPARSPTPPPRRPRAASRSWSRGRARNSRDASEILPPTGTKIVVERLSKNVREAHLSEIFGHYGPIQDLDLPINRTFGTNRGTAYILYEHREDAEEAIANMHEGLIDGTTVNVSIVLPRRIFSPEPPLARRGANIDPRFSGSGTRGGRVHRGYAPAGGHRRHSSPGRYGPRPDAFALPSRSRSRSPYRSPPRHPRDPRGGGGPRRSLEDSYSSRSRSKSPLPRRASGRHGGDGFRRRRTASAGDVSNALQRRNSCESSLDGSKEIVPSIFRAANMGLDMTRSWTCASFMTYSARAGAANDSPLRPGTPNSDRLPPGPAFNDSPEVSRPASSSGGRFEPQRYFHSRRVRKGDAEKPWLVRREAKEKWVTILPILGIVVGLGLAALLVWDGIRSVIKHKYCPVLDDSFDGGGGLNADVWTKEVTVGGFGNGEFDQTTGGDENVMIQNGNLVIRATLQDADKMERDNVMDLLADGSCTSTERASCVAATNTTAGNVTVVPPTKSGRINSRRGARLRYGRVEVTAKLPEGDWLWPAIWMMPVRETYGPWPASGEMDLMESRGNNWTYAQGGNDVVSSALHWGPDPANDGWWKTNNKHRALHTTYSAGFNTFGLEWSQKYLFTYVNSRLLQVLYTNFDRPMWRRGGFPESGANGTRLADSWTGTGRDNTPFDHEFYLVINLAVGGTNGWFEDGKSGKPWLDRSASARKDFWNARAVWLPTWKQPQLEISRVLMMQQCDGDEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCK4</accession>
    <name>A0A367LCK4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_0241</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCK4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI12159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="80" mass="8786" checksum="6267CA6DA541589B" modified="2018-11-07" version="1">MCEWRAVIKTTSARLLRTPASNMTAEEAAISESGDSEKVVGSGSEGGETISDFFFFSQRTVRFHEILGPIPEDFSVCHET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCV1</accession>
    <name>A0A367LCV1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1333</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCV1"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="65" mass="6889" checksum="F5D97210CB74CF8F" modified="2018-11-07" version="1">MIIAKSLPLTGATTKQPMTGLDNVPGARKFPNDDEGATQQQIVTSPPPLPPALSPPLPFRPPTSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LD50</accession>
    <name>A0A367LD50_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stress-response A/B barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1106</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LD50"/>
    <dbReference type="OrthoDB" id="3830014at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="1">
        <location>
            <begin position="5"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="109" mass="12364" checksum="F61F216AAF8F2741" modified="2018-11-07" version="1">MSPQIHRITLFKIPDEEHQKHLLDIYRQMPANAVKDGKPYILSVTAGRAKPDQRAQGYTLAVVSVFSSEEDMKYYDDECAAHADLKAYAKTVHQGAMMVYFQNELPTCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDD9</accession>
    <name>A0A367LDD9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_0983</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDD9"/>
    <dbReference type="STRING" id="1330021.A0A367LDD9"/>
    <dbReference type="OrthoDB" id="4911552at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI12435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="497" mass="56589" checksum="FED2EA80E2BF16D8" modified="2018-11-07" version="1">MDGRRHTERDILHKLYRHHLSGSSSQTSNMIKGMRSRSSPKFVLCQYMNYGWQPSFHPSSLSPSRTSLYKSDDWSALDRGAWLLSVLPPTLNVTFTNAYGGTWQELADDLNSALDSITDKITMYQILMWYSRAAEGDDKVCWQTDYSLALERYENPLGALNSLFVDPDTMEDDETYTKRPMDLPPLYLETSALHCLHPDSLLYDQMADLVLGVSAKWPDKKISIEQFREKTDKAAHPFGRALFHAARETYDCPYFDGCSTKNLYGGIPYLAPSFNVFLGTMQSMLIERHHVCITFEEVMGIPSNAYVFASSSYNNGRPRLLAAGCRSKPCYKQFNEALTAGREFCHPYHLEKGLSFFVHADVFSKPTECGKSILILLAEHFSPVCECLRTSSSAVYCARLPCYYELMTGSDYHIDKLKSDCRTGNLSFNRSLAFPYSFSPSKPACGMPMVEFSVDERRLVCECARVRDDEEEMLFQNYYNMSGRMNKRGMSLMRPLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDI3</accession>
    <name>A0A367LDI3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GrpB domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_1160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDI3"/>
    <dbReference type="STRING" id="1330021.A0A367LDI3"/>
    <dbReference type="OrthoDB" id="630895at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007344">
        <property type="entry name" value="GrpB/CoaE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34822">
        <property type="entry name" value="GRPB DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G01530)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34822:SF1">
        <property type="entry name" value="GRPB FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04229">
        <property type="entry name" value="GrpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI12479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="22762" checksum="68A697A16F34186D" modified="2018-11-07" version="1">MPIPIEAIVKNYDCDPALAQRLATRPSPPSLTIVSPNRRWPSDYADLHAVLVSALGPTAISIGHTGSTSVPGLPAKDCIDVDVCVADVDDEGAYVPALEEAGFLFLLRERSWHGHRLFCRADPGLQPVNLHVWPRDCPEVERHRIFRDWLVREPEDRALYARVKREASAAALEAGEGVEAYNLRKEATIRHILDRAFRHLGYVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDT9</accession>
    <name>A0A367LDT9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_0810</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Tom5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDT9"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006626">
        <property type="term" value="P:protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019603">
        <property type="entry name" value="Tom5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10642">
        <property type="entry name" value="Tom5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI12589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="146" mass="16080" checksum="B49E348EE6216C7E" modified="2018-11-07" version="1">MFGGSSFLFSSFPPPVAPAQQSAEEIRAMEAEAAFTLQQVLTTAFMLYLCMYNRLPPHASVTPFRRGVRKLTCISLPPLDQRLSPSTWLLGSYSLEGDLASHRVGASSGETPTATWGFVIKLGECTIVYMCRREERSVDCPRLTLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LE15</accession>
    <name>A0A367LE15_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Tyrosinase copper-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_0161</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LE15"/>
    <dbReference type="STRING" id="1330021.A0A367LE15"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF131">
        <property type="entry name" value="TYROSINASE COPPER-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016925812" description="Tyrosinase copper-binding domain-containing protein" evidence="3">
        <location>
            <begin position="17"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="107"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="5">
        <location>
            <begin position="288"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="506"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI12656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="567" mass="63742" checksum="6F7A9834E0335D2D" modified="2018-11-07" version="1">MLALYLVLSTALVVLGQRSVQRPPFAVGGIPVQRNGPIPPRRNINDLQREAGPEWDLYVQALAAMQRVNEADDLSYFQIAGIHGLPAIEWNNTGPRVGRGFGGYCPHGEDLFLPWHRPYTALFEMILNNHARRIASSYPTSLRNRYIQAAQALRAPFWDWADNSDVPPSTTVSRLSINTAQGRQSIDNPLFTYRFPADALQGRFTAFSPGNAQTVRCPPRNYPASANANLRRENLRERMYQAFIYATTFSEFSSSRGNSQNLEQCHNSVHGSATCGNQFSDPRYAGFDPLFMLHHANVDRLWTLWQFARPEAANFIGSYSGGSRFSTAQGTTITPNSPMAPFFHPNGRPCTPNSVSDHRIFGYTYDGLDSGRRRSDTEYIGRSARRTINELYSGRQYSPLHREPHKAHLAHLSYRAEELRGPAKIDLYFCDKYVGDVYVMPEPQTGPITATLPVDDAIKACGKTTEDLRRIANHMSAQITTTYGREIPISSIPSLKLEMEDLQEIPNPSMDEFPEIRDRHHAPGQLRQYGAEQRQQDDGSDGEAEYAPQEQSQEARESGDQQYGGQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LE79</accession>
    <name>A0A367LE79_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">tRNA wybutosine-synthesizing protein 3</fullName>
            <ecNumber evidence="6">1.8.4.8</ecNumber>
            <ecNumber evidence="5">2.1.1.282</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="21">3'-phosphoadenylylsulfate reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="23">PAPS reductase, thioredoxin dependent</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="22">PAdoPS reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">tRNA(Phe) 7-((3-amino-3-carboxypropyl)-4-demethylwyosine(37)-N(4))-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">L249_0859</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27 28">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36635"/>
            <dbReference type="Rhea" id="RHEA-COMP:10378"/>
            <dbReference type="Rhea" id="RHEA-COMP:10379"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73543"/>
            <dbReference type="ChEBI" id="CHEBI:73550"/>
            <dbReference type="EC" id="2.1.1.282"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>[thioredoxin]-disulfide + sulfite + adenosine 3',5'-bisphosphate + 2 H(+) = [thioredoxin]-dithiol + 3'-phosphoadenylyl sulfate</text>
            <dbReference type="Rhea" id="RHEA:11724"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:58339"/>
            <dbReference type="ChEBI" id="CHEBI:58343"/>
            <dbReference type="EC" id="1.8.4.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 3/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1">tRNA modification; wybutosine-tRNA(Phe) biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PAPS reductase family. CysH subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TYW3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.4.8" evidence="6"/>
    <dbReference type="EC" id="2.1.1.282" evidence="5"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LE79"/>
    <dbReference type="STRING" id="1330021.A0A367LE79"/>
    <dbReference type="OrthoDB" id="7869097at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004604">
        <property type="term" value="F:phosphoadenylyl-sulfate reductase (thioredoxin) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019344">
        <property type="term" value="P:cysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019379">
        <property type="term" value="P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23945">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000151">
        <property type="entry name" value="Phosphoadenosine phosphosulfate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1960.10:FF:000003">
        <property type="entry name" value="tRNA methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1960.10">
        <property type="entry name" value="tRNA wybutosine-synthesizing-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00063">
        <property type="entry name" value="CysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004511">
        <property type="entry name" value="PAPS/APS_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002500">
        <property type="entry name" value="PAPS_reduct_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011800">
        <property type="entry name" value="PAPS_reductase_CysH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003827">
        <property type="entry name" value="tRNA_yW-synthesising"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036602">
        <property type="entry name" value="tRNA_yW-synthesising-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00434">
        <property type="entry name" value="cysH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02057">
        <property type="entry name" value="PAPS_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002537">
        <property type="entry name" value="PRK02090.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46509">
        <property type="entry name" value="PHOSPHOADENOSINE PHOSPHOSULFATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46509:SF1">
        <property type="entry name" value="PHOSPHOADENOSINE PHOSPHOSULFATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01507">
        <property type="entry name" value="PAPS_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02676">
        <property type="entry name" value="TYW3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111278">
        <property type="entry name" value="SSo0622-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="15" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="14" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Phosphoadenosine phosphosulphate reductase" evidence="25">
        <location>
            <begin position="66"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA wybutosine-synthesizing protein" evidence="26">
        <location>
            <begin position="761"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="24">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="24">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="24">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00030554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00052536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00058049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00069229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00078053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00082472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00082553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF01507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF02676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="RCI12720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1036" mass="115436" checksum="D610D56BF94F4DC0" modified="2018-11-07" version="1">MAHFADDHDPESGYVSAHSDSSPRPSSKSRPNVSLTREHVDFLNQQMETMHPMDILRFCTIMFPNLYQSTAFGLTGLVTLDMLSKIQRERGSSKPIDLIFLDTLYHFPETYELVDRVRQRYPDFRVHILKPEGIETAEQLEETYGKELWNSSSELYDWMVKVEPLQRAYDKLCVAAVLNGRRRSQGAARGSIPIIELDDERAIIKINPMAAWTFSQVSQYIKDNDVPYNALLDRGYKSVGDWHSTSPVQDGEDERAGRWKGQMKTECGIHNKFSRYAQYLAAAAEKEQDASQQVVAPEGLIGYERALESMCSYRALIENPLWLRLTVGSKGMLERRGIPRYLVPWTILIKGVRSPLVENQTAVVPCEAHQGHVVQIDLQDPRVQDRARNYVSARSGRVIHVAQAAYFPRLVVKKDLNTTLSHELYLCAEVVQKSDRFVESLIGLEPLQIIKEVVGIGCAKDKRVSPGLARIEGKVVTRWGLVRGIRGLKTAVFGHSSTARVWIKGVGWPSHEVIRSLDLCSFELITTALTRKEETEVRECQEPGEECMALPVVCQPAVGCPAAGEIGIVFYDTTLPILLNDGPYLEELPTSSVLATFNATEELQLLYPPLDIHHSSSIGHSWTALAIPKLLRHDASFMMSLTPSRRSTQTRHLAIYLIVAQIKSTRLKEAEIPLMMEIILLSFWSCLFHTFSIHAISKAGGCVSPPAVPPAEFDYVVEKNHDVTLQEEITTPPSSLSHVDSQSPAMRQQPQLPAPIASFDEKKKRILQQLALPVEEYTDASPKGSVDEAIRPLIDDINRVEGFVTTSSCAGRVSVYLEGHKIKDEGRAQTAGVGGKGAGGTWLFVSHEPVAREASWIDSLAFSETSSAAKGPADRLIHFKFEPMILHILTTSPQHAQLVLRAGLQAGFRESGAITIDDPTPMVAIRSLGLGFESLVGCQSASDERRRCLVSADYLEILRAISDERFVENANRIERFRSAFLLAIQGPSPRADGWEDAATRRERMQAEGLRRKAALEIEGKAESVRDMPFCGNEAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFY3</accession>
    <name>A0A367LFY3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_1348</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LFY3"/>
    <dbReference type="OrthoDB" id="419768at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04041">
        <property type="entry name" value="C2A_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04052">
        <property type="entry name" value="C2B_Tricalbin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21676">
        <property type="entry name" value="SMP_Mug190"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057349">
        <property type="entry name" value="C2_Mug190_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037767">
        <property type="entry name" value="C2A_Mug190-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037765">
        <property type="entry name" value="C2B_Tricalbin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47348:SF2">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED 190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47348">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 190 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25331">
        <property type="entry name" value="C2_Mug190_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25669">
        <property type="entry name" value="SMP_MUG190-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1228"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="11">
        <location>
            <begin position="513"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="11">
        <location>
            <begin position="732"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="172"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="391"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="763"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1066"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="133"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="197"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="764"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="774"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1066"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1110"/>
            <end position="1125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI13335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1360" mass="151263" checksum="F606D14020315FF3" modified="2018-11-07" version="1">MSLMDDLDDVRRYQAPYGARRPVPTISRYLEEKAARQQEALRGNENLDDEDDEEDDDEAADDAMAPTSSWGLLASGNPERRPSKSSFAGASRTQIDDREDDDGKAGMDYGGTNGGDLQQPLEDTSQVSPGTAHPKHRRRKLRSRKRERAEREVTDPITHLPVMIHDFTSDSLAQLDYNDPPSGTTPETATGAAGKHKSAEELEREQTSTQRDHDVLVDCFPPPELEALGRNMVAIFERSLILGLTGMAVIGWIVLRAAELEPSTLGAVAGIAAVTGLVMAVSAYAARKMDGLFRDELWDAQRRRSAARVGRDSREEAESTAWLNSLLNAVWPVVNPDLFASLSDTLEDVMQASLPRFVRMVSVEDIGQGSEALRILGVRWLPTGAAARTVRPDGTLAPDEEDSSGGQDAMAGEEGDFVNLEVAFAYRTRSSSKSLKDRTKDMHLYVAFYLPGNIKVPVWVDLQGIVGSMRVRLQLTPDPPFFALCTMAFMGQPKSAVDAAVAEYVAPKSLTVDLKDMLAGDDFKKDTNSTGVLMVNIRRGYHFKMGDVGIPLFKEGSSDPYVSVAWAKFGKVLWSTRVIVSEMEPVWDETCFVVVTPEELNIDERLRVQLWDSDRFTADDDLGRIEVPLKELMTDQRSRGRMWERVDGFHALEAGGEMPGKLEWSVGYFPKTGVEPCQFSRQTYDPDIRSMAQLRASVDIKCEKKLRETMLKDGKADRDEAELDKIKAQEFKQEQDAMVMSAPPPDGYPSGLLAMQIHNITGLELDKPNKRQAEDDDEASDEEETGENLPSSYCTIIINHSKTYKTRTKPQNAKPFFNAGCERFVRDWRECEVFVSVRDARLHEDNPLLGIVHLPLAEVFKEKSQVMGFWPLSGGIGHGRIRLSLVWRSVALQAPRNLLGWSYGTLEVEAQATSPDCLEELRSCKLKLTTNISMGKMQPLTPGAGAAWQAKKEQHLSLAVTRRYSSCLAVAFKNKGFFGDKVAAFCVLWLKDVPDEEEQTVELPIWKGDRERAMACCLDECGERVGSLRMRLTFLAGMGNAHSKWASRKQNLRDVVEVMEMARDNLDTDAMRREAGPVSDEASSDSDSSDGGDGAKSIKSVGRGSIPDGSVDHRQGPLDQVRDYRRRDKALHRQHRGIMQWKVPRTARWVKHKIGRVGGGVSDLFDHHSRTTGVETETSSVGTSLDKKSTVIESVTTAVLFATGDITAQQLVDKRGIKGHDLKRTGRMALYGGFVFGPVATTWIGFLSRKITFANRRVEALARVACDQSFFAPVMIGVFLSSMATMEGASPKERLEKTWWPALKTNWMVWPFVQMVNFTFLPLQHRVLFANIISIGWNSYLSWVNSQSVAEQGVRLPAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LG39</accession>
    <name>A0A367LG39_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="6">PPIase</shortName>
            <ecNumber evidence="6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_0300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 6">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclophilin-type PPIase family. PPIase H subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LG39"/>
    <dbReference type="STRING" id="1330021.A0A367LG39"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000035">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="7">
        <location>
            <begin position="3"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI13381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="170" mass="18492" checksum="B8D18C33CC3F18FD" modified="2018-11-07" version="1">MAPTQLPASGEPLGRITFELFKDVVPKTAENFRQFCTGESKDSGGRPQGYKGCKFHRIIPNFMCQGGDFLRGDGSGSTTIWGFRSFADENFTLKHDRPGLLSMANSGPNTNGSQFFITTVPTPFLDNKHVVFGSVVDGMDVVKKMEATKTGYKGKDVPNLDVVIGLCGEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGL5</accession>
    <name>A0A367LGL5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_5607</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the peroxiredoxin family. Prx6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LGL5"/>
    <dbReference type="OrthoDB" id="10001928at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03016">
        <property type="entry name" value="PRX_1cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000011">
        <property type="entry name" value="Peroxiredoxin PRX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1020.10">
        <property type="entry name" value="Antioxidant, Horf6, Chain A, domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045020">
        <property type="entry name" value="PRX_1cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503">
        <property type="entry name" value="MCG48959-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503:SF2">
        <property type="entry name" value="NEGATIVE REGULATOR OF SPORULATION MDS3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016588463" description="Thioredoxin domain-containing protein" evidence="9">
        <location>
            <begin position="18"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="10">
        <location>
            <begin position="77"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="283"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="371"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="508"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="681"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="986"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1167"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1273"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="303"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="390"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="406"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="522"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="986"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1014"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1181"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1220"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1282"/>
            <end position="1308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI13558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1308" mass="140045" checksum="24D5D8620EC1B8A0" modified="2018-11-07" version="1">MGWLAHWLLLSVDCCTYKKPSLPPSTPACMRACAYYTQTHKHTHTHIPHLLHSLRFLSFFPKHIFHLVRHPVTMATLRLGSEAPDFAAETTTGPIKFHEYIAGSWAILFSHPQDYTPVCTTELGAFAKLEPEFTKRGVKLLGLSADKLHDHEGWVKDIDEVTGGHVKFPIIADPDRKVANLYDMIDYQDPANIDHNKMPFTIRSVFFIDPKLKIRTILSYPASTGRNAAEVLRIVDSLQTTDKHRVATPIDWQPGQDVIVAKDVKDDEAKKLFPNFRVVKPFKPSAPCAPPRKNSAPGLTLPSSSSSSSSTTTTTTSTSNTTTTTNSSSSTAASTSKHARQLSLQHSLSKPLPQSPLLSSSLPALRMTTMGSAHEQQDMSSSIGSLASSARRDSIADESKSRPGHSSAPGRPSARSAHLSGLMCNVHRTTGREPPPLVGATTTVLGDKLFVFGGRVLARSRPAPLVADLFELDLVRRHWSKLETTGDLPPPRYFHSMCPLGDTKLVCYGGMSPSPPTPNQPAPDQQQQQESAEQQQQQQQQQKQPQPEVSVMSDIYIYDVPSRCWTHVPTQDAPQGRYAHCACVLPSTANFSSTRAPLSALQLNPSSSAANPAEGRIGVNIDGSGGAEMVVVGGQDGNNHYIEQISVFNLRSLKWTGTQPLGKSCGAYRSVAAPLPLSLAGKIGRAGPQPQPQPQQPQQQGQDGSGSSMLIYSNYNFLDVKLELQIRSSDGTLTERPMSGTYSPPGLRFPNGGIIDTHFVVSGTYLTSSKQEYALWALDLRSLTWSRIDAGGSVFSQGSWNRGVLWNRRNTFVILGNRKRSLVDDYNHRRINFSNVCMVELEAFGFYDNPRRTSPMSGFVSASSPYSGPGLSVTRKAGYTAGGRTHSRASEELGEKALGIRELADMDLLCIGGERIPVNSRIVARRWGPYFVQLLREGSAAAPIHSTMGRPAELTGGGELDSGGGDLASNPLRVSALTITPTTMTTTATTTTTTTTTTTTTTQQTASGGENAMTSAPASSTTNPASAPDTGEDINPAAVNTAPTPRSLPPGTRPRCLYLPHTSLTVQALVHFLYTSSLPAVSSPLCTPQILCSLLQVARPYRVDGLLEAVVERLHTLLDSRNAAAVFNATAMAAGGGRGIDGSLNPNFSVGILDPILAPTATSDFSLGGASAINGSDEDQQQQQQQQQQQQPSSQRRPTTPAGGSGLRLNIAAAQRHSRTPSAELSATTSISGSEWGSEMGGGGSESRRPVWNGELSSVIGLQKRGLRGLMEGRRIRERSGGVPGGSPSYGGGGGGGGSRVGLGIAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LH20</accession>
    <name>A0A367LH20_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Vacuolar ATPase assembly protein VMA22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_7956</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LH20"/>
    <dbReference type="STRING" id="1330021.A0A367LH20"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990871">
        <property type="term" value="C:Vma12-Vma22 assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040357">
        <property type="entry name" value="Vma22/CCDC115"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31996">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31996:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21730">
        <property type="entry name" value="Vma22_CCDC115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="4"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00093634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI13710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="177" mass="20131" checksum="A37512FF0F44FE04" modified="2018-11-07" version="1">MAAQQEEQQQQEQQQEHIDRLLQRYLDLLDQYTKLRAQLSTLLARVYRDLARANFSAERGMRYGESHYDGRMRATRLLSLNEDAGQPVIVIARPGDGEQPTPCKDPLRWFGMSVPTALRTAQSQSVEAVERIIPALVSVQAEMLAVEIEVRRARKRRDRAPVSSKDDVQQAETVEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LH64</accession>
    <name>A0A367LH64_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Guanylate kinase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_7948</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LH64"/>
    <dbReference type="STRING" id="1330021.A0A367LH64"/>
    <dbReference type="OrthoDB" id="10257415at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021861">
        <property type="entry name" value="THO_THOC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13265:SF0">
        <property type="entry name" value="HPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13265">
        <property type="entry name" value="THO COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11957">
        <property type="entry name" value="efThoc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016883344" description="Guanylate kinase-like domain-containing protein" evidence="3">
        <location>
            <begin position="27"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate kinase-like" evidence="4">
        <location>
            <begin position="993"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="613"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="693"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1153"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="615"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="631"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="707"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI13739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1175" mass="132025" checksum="957FB4A906700197" modified="2018-11-07" version="1">MLVGSPLFILAILGLLLLVWLIRCLASPLRHVPGPPLSPFTSLGLRWRELGARRTAYIHRLHQQYGPIVRLAPDQVSFTSWPALKEIYCSGGSGYDKSDFYDMFKIFGRRTMFTMLNRADVSDGVVVLPLAERLTPGDQHAKRKRIIADRYSSSNVMRGLAIQGIQRRSRTFLRRCASASQSRTSDIFQVTSDDSIKTHHYPILHWLFARLLFWFAKPREVPLVDDYVLSATQGGDVAPFTLLNRLRDKSDLVDSTDMAAECLDHMVAGIDTTGDSLCFLMWELSQPRSLVFQRRLTDELRDKSGIPTEQLPFLDAVVCEALRCYPAIPMSLPRLVPPGGRFIDGVWLPAQTVVSCQPYSVHRINEDIFPEPDVFNPDRWLEPERDADRRRLLFAFSNGGRGCVGKQDLLRQLLDEAPQTSSIEPALNQSDFENLFGRVAESLASDGDASRSREAAKTHQFAIIETAARDVFDRLIASTPIESPEFVKMWHLLDILSLLSDNGQCDPALLFWLVEVLLDSQTIAGCRTIFDYLESRRERIMAKHFKQKNLVILRSCNELLRRLSRAEDTAFCGRVFIFMFQSFPLGDRSSVNLRGEFHVENVTNYEVSVPTAEGSKMDLDSQEAPKDSTDAKAATKTAASGASKAQKAFDPDSLYVSFWSLQESFSQPLKLFEPEHLARFKSNLEATVKAFQATHNNDGPHASKSTDGAKRDSRRKKEEDAADDGPETFNPKYLTSRDLFELEISDLSLRRHVLVQALIIIDFVLSLSPAAKEKLAGANASNKSVMYNDGFDDENIKWANDMKATISDYLKRGSDGPYFYRMVETVLARDKNWVSWKMASCPPIQREPVSWQTFNEAKENAQRLATTKRLRPTPLNAVNMDFIREDHFSRNLDLRRDPARYQLPDLNSFKQGIADDDFEIATAKDEETRSLATARKASKTWRALRLASTFKLAAFDKIDDDDDISRLFDDLPDSDDEVDEVGSWDEADLPDNRDPVVIAAAPGVDAESLTGLLAHHSRGFLAPVVRHAAREAREGEVNGRDFHFVAKLDFNQLRDGDRFIEYGESEGVDYGTSFSAVDAAVETGKVPLIVLNVESAQFARDMDFAARYVYVTHAQDEPIAGSYDKVMVASDPMQVVDGMMAYVFGMERYPDEADGDASMADAQTERPVGEDADDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHD4</accession>
    <name>A0A367LHD4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">USP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_8008</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LHD4"/>
    <dbReference type="OrthoDB" id="420187at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02659">
        <property type="entry name" value="peptidase_C19C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000136">
        <property type="entry name" value="Ubiquitin C-terminal hydrolase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021905">
        <property type="entry name" value="DUF3517"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF827">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12030">
        <property type="entry name" value="DUF3517"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="1631"/>
            <end position="1959"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI13809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="2591" mass="289524" checksum="29528E222503A80A" modified="2018-11-07" version="1">MDPASTPSTLPEIIDEAPEPEPPVTRPNPFDDDDTSSRKRRRTSVSGSPAASFEPANTMRDTSGIAVPDSTDAMIVEDSLNEPRTPENHRLDEASTVDPPSSKVTINIRKRNSSASPTAALASSLSRPDTHSSSSPSIAPEEISMEDAHEPSSASHRSSSLSATPPIEIVADADSGGVPVLENMPDSGANVLILDPTLQFPYTEADECLSDTLQRLTQYLSTTKPIDPSILIQVSEWLDEYLRYAKHADPNAVLLSRRTYQNFWLSFPDPILAVTTRRAEHLRHPALRTAVLNFYTSFAELSARFVQLDCLALSDAETLSTPSDRRAPYLLSPIYLQQLHGVIGPHGLYPHAVSDGGAAGGWIHSELESFLMDKFQAFPGGSIESLSQLSAAMVRLVPHFPRLMDNVAPVCQMLAACMKSTQRALRLGQEPPAQVMERLEQGHEAWVVLSSALVTTIDKQVTSLSSDQTAASIQALMEILKASLQGEHKCAVGMLEEQRKKYPAIPPNFAQEAIAWQWKVDILEKLIRSSQMQLRVMAAANMCNNLVTLWKRLCDGGEMFSSDFLEHLSGYLLETGLVDYILGANCHPEIIIESANIIGFLVVTRTYRAQHTDHVWRVITSSQDPRVVDALTRMMTNITNLCDFPGLLYLCEKFGALPVDRFTPSLRLLLENVLGEMIARSQADQTTLTFQPFGLCLRLLRESSICASGSQVVDPEMQQVAMQKFRELLGHGPDAEGRRKLYLSCIEDISAKSVTTLGSLWCLSMAIRHATVDQMQLLTEHHDLAKLIIEELEHAGEAGRAAGVFPILSGKSNQPRRDFVTNLIQHQPGAITGELGLRLWNILVGPQSTCLDDRKAGWHIISSLARKASPPSAFLQTCFSEYLPKLSAAYFCEGTLEFVKERLVRFFLEESREFVFDDAATVSRSGIEQLWRIILEADNPALVGQAISILAVEIYLESNAIASYPMHRARQVHLALVIRCLRQMKETAIRIKGTGGGSTSGDGEPMVIVGFDEEMRQQELIFVRSLQLLRFFLEKYQSKPNFAVADLRSFMSEVPEQIDGESARLRYQSFGVNEETDILPLNIGRLNTVSSLLATIRAETGFDSFRVYYRGHQLLPTKKDVCKSLQDLDIQDGFILVKREENYSASPSRIKPGSLPLEVEILAHFAELWDYLSMDDKIAEQIYDFVVRLPADGYIMSLFDKDETSYRDLFLSGQPFKSLYAIHALVEYVDTASNTGAGNTLASTSPTSSHEEALRRAQHFVVQALSDPGVLQGTTDRLQVRLASALMQEFVALASGAYKSRQRFVDRCIDAPAPERLMEILGGALDHSDDEALPLISNTCSAVLLVSKLNAQFWIKVTQGDVLRDLLQKLILLDPRKAVRVAATQLIEASIEAEVQAWQTELQAQETPETEAREPFALAQYLWPIVSGLLAEAVRFPAQCEEFFGLLKMLLSRLSTALSGQMQLNELAGHTSSLLLQHTSTEDVSQQAPYDPVASSLASALYLCLQIDASLLTSGMLPKDLAEKLMWRHLFPQKLDEGATLVPRVVLNSETRARLYDIVLLIVKQDHHQLGQLLQLLDDLVPFYSENFGGYWPIGRGSPLSDVEGPDEPYAYDLPFQFERAKAMRSPCGYVGLRNLSNTCYLNSLLTQLYMNTGFRRFILGVPCLAKEGPEQLLSYTQKVFAAMQESYRRFVDPSDLVSSIKTYEDTVIDIHNQMDVDEFYSLLFDRWEGELLQPDDKRTLRSFYGGQLVQQVKSKECEHISERLEPFAAIQCDIKGKSTLRESLQAYVDGEIMEGDNKYKCSTCDRHVDAVKRACLKDVPDNVIFHLKRFDFNLRTLQRSKINDYFSFSTTIDLRPYTIEHLDQATSAAEEDLFELVGILVHSGTAESGHYYSYIKERPSSAGRESWVEFNDDMVTPWDPSLMASSTFGGPDNRPVYETNGIMYDKSYSAYMLFYQRVSSLKAEQDAMVAQQLASPLLVAMPSWMREHIAHENIDILRRHCLFDPGHATFVQNCFTRARFLDAKAGSGSAAVEVADDAGEASHEVQDLAMEMALSHLDQIITRTKDTPSLVTFSNMTRAAVANCPKCALALYFYFDSRHVAFRALLQRCPDQQVRAFAGEVLIKAAQTISEKWPRLYRGDGLAIDSPDTASDGDEMDHDLDLDLEHSVMQGVVNLFNCLWQFFHVHLRSWDEYFGTILAFAKLGDREVALLLSDNYLSKLLRIVTADSTIDLAPNYARMLNNVLRRISTRPPSYSAILSLIEYLLGQLDPVLGPDVIVDRPTDRLTLQAPFPWTSDEVHMFHYHPNHQSLSFFVEKLVSIDQVWGTTDDIVARLTSTGDVMDSRAANVLRRNIQGDLSTQPMDPYLRVAARYVECSRSADRVHTLVRHVGAQARGLQNSEGLAFLNFFRVALTSEKPGEQLARLRRESSLATVPAWAPHLLVYPDANTRREAEQLLDDELFPPATGKEGDKATENKEQVDQVVRELGLKCLIYLREAHVKRRSRIERDAAWSILRVVTKCGGTDMECSDEDNEFVAIQAEIMDPLRRLMVDEVEEDASDWDDSCASSDPMDTNVGVPVQTMNELNDADLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LI01</accession>
    <name>A0A367LI01_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitin synthase</fullName>
            <ecNumber evidence="3">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_8093</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:16638"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI14054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LI01"/>
    <dbReference type="OrthoDB" id="27832at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000052">
        <property type="entry name" value="Nonsense-mediated mRNA decay factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000037">
        <property type="entry name" value="Nonsense-mediated mRNA decay factor (Upf2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.80.160:FF:000001">
        <property type="entry name" value="Nonsense-mediated mRNA decay factor (Upf2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000077">
        <property type="entry name" value="Probable chitin synthase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039762">
        <property type="entry name" value="Nmd2/UPF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007193">
        <property type="entry name" value="Upf2/Nmd2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 2 UP-FRAMESHIFT SUPPRESSOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12839:SF7">
        <property type="entry name" value="REGULATOR OF NONSENSE TRANSCRIPTS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03142">
        <property type="entry name" value="Chitin_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04050">
        <property type="entry name" value="Upf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1174"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1214"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1257"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1615"/>
            <end position="1632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1638"/>
            <end position="1656"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1663"/>
            <end position="1681"/>
        </location>
    </feature>
    <feature type="domain" description="MIF4G" evidence="13">
        <location>
            <begin position="467"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="MIF4G" evidence="13">
        <location>
            <begin position="672"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="172"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="420"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="904"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1011"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1734"/>
            <end position="1764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="924"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1020"/>
            <end position="1033"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI14054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1847" mass="210472" checksum="4F5B1307BD759980" modified="2018-11-07" version="1">MDRARKRELRSLNERAWSGDKDLFTVGGSLHSSLKKNTAFIKRLRTAISPATLGTFLQEIRTLSLHKYLSEIVSACYEGLCRLKSPGEVEAGVEIVSALHQRFGPADFTQYLAWLLGKGMATPDKGFLKNLTPEAREKEEKERIIRQRALLRVITELWLVGALRTLDDAIKPDDATKGAAGKDIELKPRSNSSKGSSAEPFPLEVLKDLLGHDRDHTNLPLLVVFVKAFSWDVLGIKPTTMPEPRKSGEEDSYSNAPFRAIQVNDEIPDSIVAELPFTPPDVAERFRNVLKGYYDDVAAHIVRDQKSIQSQARRNAEAYVKSGEVFEDRRANFEKLVKAQDKMITNAQVIADILGAEMPDLKESDDPLATSSGSIGLVKTGDYLRSMGEGPGIWADEDERRFYENLVDLKGKVPPILLEDGRKKKADTDDQVGKKVDQPDTPDATKSAEQADEPSLAIANKSIGAQVDALLLRLPELTNKDIIDQTAVDFCFLNSKASRNRLIKALTEVPKGRSDLLPSWSRLVATLGRYLPDVPKGLVDYLDNEFRSLQRRKEKEFLGQVRLSNIRYLAELTKFGVVPEHVVFHCLKVSLDDFSRMNIEILCNLIENCGRYLLKTPETAPRMQSFLETLQRKKSVQHIGQPERMLIDNAVYYVDPPERPAIEQKERTPMELFMRRLVYGDLTKRNYGKVLKQIRRFHWEEEDVVSLLEKVFSRPGKVKYGNIHLLAILLSSLHRYHPEFAVKVIDNVIESVSFGLEQNDFRFFQRRIAEVKYLGELYNYRMLEHPVIFDTMYKILTFGYGGPPVPGRLNPFDPPDDFFRIRLIATILETCGMFFNRGAAGKRLDYFLSFFDYYVHTKASLPMEMEFVVHDMFAVTRPQWKLAASLDEAAKAFHLAIAQDQKTAGADKAIEGDEATSEVSSEYENGDVDDMEPYGDGEDDTASDEDEVEQDDDDDSARQSDLDEDIVVTRQEEMVDPQEEAEFEREYAKMMAESLESRKFERRQLFDVPLPVRPKHRDGSTSTAQDTDSTAAGNTMAFSLLTKRGNRQQTRTVELPSDSTFAIAMKTQQRVEKEEQQRIKNLVLNYDLQQSEDQESEFHDGIPNGGVTTYTRCAGLDRLPALHQNRAEKPDLVHMRLRGTTRWPPRTDGRSKTYVAPIRRTLPAYHLLLLPAKIVYTSIVGVVMLMACLEWFLWLAAFVYCLVKVFRKAEHWSIRLLCIGVGFAFALLRFIFLPIMVVTLPLPNQVSRHWPRSAVSFLQWFAFWSFAILLTVPWLFCIYQLVTNQLGRTKRIKRVLDDVTAPKVVIVMPCYREELDVLVKAINSVVDCDYPPACIHVFLSFDGEQVDDLYLKTVETLGIPLFTGAEYPSSIDVTYKAARITISRFPHGGKRHCQKSTFKLIDKVYAQYLKRNDNLFILFIDSDCILDKVCLQNFVYDMELSPGNARDMLAMTGVITSTTRKHSIITLLQDMEYIHGQLFERTVESGCGSVTCLPGALTMLRFSAFRRMAKYYFADKAEQCDDLFDFAKCHLGEDRWLTHLFMIGAKKRHQIQMCTSAFCKTEAVQTYRSLVKQRRRWFLGFVTNEVCMLTDWRLWKRYPTLIVVRFMQNTIRTTALLFFIMVLALLTTVVKVDNLPVGFIAVSLGLNWLLMLYFGAKLRRFKVWLYPLMFVLNPFFNWYYMVYGIFTAGQRTWGGPRADAAAADSNTTAREAVERAEMQGDELNVVPESFKPAHEARRAASRSHSQRATGLGRQRSVVRPPDKIDGKFSARQRMATGIYAHPDESSAIMAAARLDSWGPGDWRDSLESFDSECKAPSATIKVDKFMGEEDRRKYLIAQHAQMQRKGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LI30</accession>
    <name>A0A367LI30_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L249_8257</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">High-conductance magnesium-selective channel that mediates the influx of magnesium into the mitochondrial matrix. Essential for the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing. It also suppresses a variety of mitochondrial intron mutations and its absence may disturb the assembly of mitochondrial membrane complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homopentamer. Forms homooligomers. Interacts with MFM1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Mitochondrion inner membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI14093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LI30"/>
    <dbReference type="OrthoDB" id="10251508at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045016">
        <property type="term" value="P:mitochondrial magnesium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12823">
        <property type="entry name" value="Mrs2_Mfm1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.340:FF:000005">
        <property type="entry name" value="Inner membrane magnesium transporter MRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.128.330:FF:000002">
        <property type="entry name" value="Inner membrane magnesium transporter mrs2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039204">
        <property type="entry name" value="MRS2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890:SF0">
        <property type="entry name" value="MAGNESIUM TRANSPORTER MRS2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890">
        <property type="entry name" value="RNA SPLICING PROTEIN MRS2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22099">
        <property type="entry name" value="MRS2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="26"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00046105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU366042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCI14093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="482" mass="54252" checksum="50E5EE15C863A09D" modified="2018-11-07" version="1">MFIFIVARSRQVVDFLLLGRRTTTTTTTTSAQAKGKDPTTTTTTTKDKEKDAKTGSWKERLFLGASPSGRKRGGGVRALWNDVDEFAPGGSSMFNSRRVLTAKAALEPMLRCTEVDENGKVILTDGEFKKTELIAKFGLLPRDLRKIDSSNLPHILVRPSAILLNLLHLKVLIKHDRVFLFDVFGSKTSYPQSAFMYDLQGKLQKPSQGVNGLPYEFRALEAVLTSVTSEMEADFEAVREPVMHILSELEDDIDRDKLRILLVLSKRVSTFEQKAKLVRDAIEELLDADDDLTAMYLTEKAGGEKKQQARRRGKDDHTEVEMLLESYHKLTDEIVQEAGNLVSGIRNTEEIVRAILDANRNSLMLLDLKFSVGTLGLAMGTFLAGLYGMNLDNFIEETPWGFGTVTGLSTLMSLLVCWYGLAKLRRVQRIKMMSHESPHNMPRGLTFRDDGALGMLDSRNREMLRRAHMQRATMAAKKSWWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LI58</accession>
    <name>A0A367LI58_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_8278</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI14123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LI58"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016926718" evidence="2">
        <location>
            <begin position="25"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI14123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="177" mass="18986" checksum="8B8F00B30A44DB60" modified="2018-11-07" version="1">MSARLGVFLLEGSVLSFFGPTAHPLPPPTTISPPTNPFPPHPNKSLPGRDKKNVVTPSSAVDRTRVDYVPEEEKKRLMENPRPNATLPDDEAVFCAAVMPLCTGTWSGPFEVIQGMRSSLGRKKPRVLSVAEQSRVSKMSIDRSSPCRGPLGQATLLAASIEGDLVPGSNRFTSPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJ56</accession>
    <name>A0A367LJ56_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_6100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJ56"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="268" mass="30307" checksum="A0DA63009EA46545" modified="2018-11-07" version="1">MDPIMGATLQSLFDRSFDFLSCHHGHLSISSAQHLRATLDTLTREYGAFSLHREAAGDNARPDPPPIRFERSLTAHRYIHPSIHNFTQNGGESVERKADTALGTQSNPNARCCITLTYKLSVEVFAQPPHAKILYESGESYTSAAPLETDMLAYGKRLAGQWEGVRRRMDECDQRRRRFGRGLETRVKKGVGSLKSSALSCSVIHIRQYPYIRNFNAKHKKDSTGLSPVVWLQPTAVVLVANHVAVSSQRRCFSMILEKRREKRRKED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJG1</accession>
    <name>A0A367LJG1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dihydroneopterin aldolase</fullName>
            <ecNumber evidence="4">4.1.2.25</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">7,8-dihydroneopterin aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_6857</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde</text>
            <dbReference type="Rhea" id="RHEA:10540"/>
            <dbReference type="ChEBI" id="CHEBI:17001"/>
            <dbReference type="ChEBI" id="CHEBI:17071"/>
            <dbReference type="ChEBI" id="CHEBI:44841"/>
            <dbReference type="EC" id="4.1.2.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DHNA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.25" evidence="4"/>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJG1"/>
    <dbReference type="STRING" id="1330021.A0A367LJG1"/>
    <dbReference type="OrthoDB" id="5425486at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004150">
        <property type="term" value="F:dihydroneopterin aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046656">
        <property type="term" value="P:folic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1130.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006156">
        <property type="entry name" value="Dihydroneopterin_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006157">
        <property type="entry name" value="FolB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043133">
        <property type="entry name" value="GTP-CH-I_C/QueF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42844">
        <property type="entry name" value="DIHYDRONEOPTERIN ALDOLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42844:SF1">
        <property type="entry name" value="DIHYDRONEOPTERIN ALDOLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02152">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00905">
        <property type="entry name" value="FolB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55620">
        <property type="entry name" value="Tetrahydrobiopterin biosynthesis enzymes-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0289">Folate biosynthesis</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroneopterin aldolase/epimerase" evidence="8">
        <location>
            <begin position="172"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI14517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="293" mass="31383" checksum="772EC8D70AB9D36F" modified="2018-11-07" version="1">MWPFRRSHQAMGEAPAIVRVRGLQTTVKGPHDAWGRPGRPQPMLMSAEVALQGAFAASSSQDALAVDTVHYGQLSKAIRASVERLSLLSALPEAEPLTTLFSNLALVWRDIRAGDNADVPSPDADIRLLDVGAVSYLLLTAFLPKASLLGDGVSLVMAGAVSGFAEEPTCALGLHGLRVPTLIGINGNERRARQTVVISVEIDNFDPSADNYHGIEARVVEETAASSFDTLEALAAHLLKIIARYLRAQRLEPGDGSGSRVTIIVEKPMAVPFADAPAVELRLNTNDVLARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJM6</accession>
    <name>A0A367LJM6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_6371</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJM6"/>
    <dbReference type="STRING" id="1330021.A0A367LJM6"/>
    <dbReference type="OrthoDB" id="206213at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015938">
        <property type="term" value="P:coenzyme A catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="NUDIX_CoAse_Nudt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF24">
        <property type="entry name" value="PEROXISOMAL COENZYME A DIPHOSPHATASE NUDT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="8">
        <location>
            <begin position="77"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI14621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="356" mass="39560" checksum="86E47F03CA7111B9" modified="2018-11-07" version="1">MSLEHHQQEEEQTTVPSTEDSILASPLRPQNEAPPPASLYYEASTMAALNAASSAAINRLRSYRPPPFPLWDSLPSKKRAAVLVLLYADRRGDLRVVVTMRAASLRNFSGHAALPGGKADNEDETPFQIARREAFEEIGLPIDDDRLPSPFRIEPLCLLPPSLARTHLVVRPCVAFLHADRSSSEQGQDESLLVEESMIPRLDSREVAALFSAPLYNFLKVEDLPPPPGQWLPPGHWYDGAWTSWKNHSWRVHNFYVPVNNQRVMRPRRRSSASSSGTGPRVAVSDDEGRFEGRLKVWGMTGRLLVDAARIAYDERPEMEHNDSYGDLDVIMTAVAEGALDDVRGHDVGDGGPAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LK53</accession>
    <name>A0A367LK53_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_6494</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LK53"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="111" mass="12550" checksum="57C647C115ECB4F3" modified="2018-11-07" version="1">MWGKSSVGKVESNEVFCGAVEEEEGGEKLVESVKVSRVRELNPGSKPQKVIQAVDKELTNRYFSRYFKVPTCSTLTYLYTCTCQSDRSDRSDPITPAITAMTRPLWPLYAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKA3</accession>
    <name>A0A367LKA3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_6728</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKA3"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="113" mass="11706" checksum="14DFABA5B2FD1FAC" modified="2018-11-07" version="1">MSNNYPSPLRIVKGIAAVTEEQEEEKVKALRNRRASFNGPPSLTYADGIIAIGGGRCTIAREKKQYARRNRVCGVAMRSHQRLSHAGPEEFVQLIKVGGGGGGGGGGGGGGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKL1</accession>
    <name>A0A367LKL1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7026</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKL1"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="105" mass="11841" checksum="3F57E9989921AE1A" modified="2018-11-07" version="1">MEEEEEEDKEKRKDIEGVSIKSDDNMMVACLLHTYGMICYDLSGNAGSRSRDEPPRLPDGDVDPEHLLDLPPAWGLRQAGADDEHPLPLWRTLLSRADLGIRLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKR5</accession>
    <name>A0A367LKR5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7067</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKR5"/>
    <dbReference type="OrthoDB" id="5242881at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI15018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="68" mass="7443" checksum="FA7A46C76012AB6A" modified="2018-11-07" version="1" fragment="single">GYNPDDTWYPARNFKNAPVALQEYYNRYVNAPGPPLAAAAADKLYNDDDDNNRATLTAAAPRLISKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKV6</accession>
    <name>A0A367LKV6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7114</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKV6"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI15049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="166" mass="19098" checksum="AB990A155B1B0350" modified="2018-11-07" version="1">MGIVIAARELGKSDFLSVRHDFLMRKNVGKKWVCLLKSVGKVESNEVFCGAVEEEEGGEKLVEMEIIISNQSVDHVIEKKKTNHVIYNDIAIRHTFPFIRITTIEVGRYDRYWYSASIAYSAPIDVQRADRCNDRCDESIGRYNRYSPTMTQGVVAGLRPNWYNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLC6</accession>
    <name>A0A367LLC6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_6920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLC6"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI15233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="96" mass="11142" checksum="004F44B176F4EA27" modified="2018-11-07" version="1">MAVPALRKQHKGIPILIDRKAPRKRLSSRQLTFIVDLTLNFGRIRKFITASILICSNWILSYCNLLINTQRCRTNEFAVLRIIFPEKFLSIESPTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLI4</accession>
    <name>A0A367LLI4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7007</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLI4"/>
    <dbReference type="OrthoDB" id="3553044at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="96" mass="10520" checksum="3CE89CA4D3379C28" modified="2018-11-07" version="1">MQQLDSFRRAGSPSSSSSSSSSSSTSSDSTTDCRPRSCEGMTDEEKRSLWKCMLALQRRYGCYNSTRIDLAVHAGEQGLGLMREFPSFNVCLGYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLM9</accession>
    <name>A0A367LLM9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Basic proline-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLM9"/>
    <dbReference type="STRING" id="1330021.A0A367LLM9"/>
    <dbReference type="OrthoDB" id="5400063at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="31137" checksum="EB68C68A1225DD21" modified="2018-11-07" version="1">MEPVPETERMEEFKPSLVPASRLSASSSSSSSSGFDLDTAAGKPPPQRRSTDPSPSTIPFRPRTASPLAASHSNPRTSALPMSRAQSMPGLGASGRGLCSPQLRPASPSGSPSRVRPLRRPVDDVFPLSSPVRASVLDSEPRCASPGSMNRRHRPSSPLHGGVAVPSSGAGGIPGSPSLSTLPSTPTSGFPLRSYDASGYMSSVPSTPTSARSRSPSISSLETIPDSPDAEEAAVEAERLARLKADAEAVDGKARSAADVPSRGRTMSFGPRDKRKRWSVCGAERRGDLDLETIWED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLW8</accession>
    <name>A0A367LLW8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLW8"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI15411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="96" mass="10953" checksum="B1895AF32ED0237E" modified="2018-11-07" version="1">MKDGFCLQCSLDNGPKSAGSECYLSILSATWLTVRLANDQRPKTKDSFVVANPGFQIWAREGVSVHLWDGMNRPKKMKRWEDAYIPLYTDMLPTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LM10</accession>
    <name>A0A367LM10_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LM10"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="109" mass="11334" checksum="A35DD50ED70A5219" modified="2018-11-07" version="1">MLRSTVGGLSLLPAKSKAVTKHRNGPRKAPLSRSPVLAEGKRHPRKFDCLVRPPFLGSLTYPTFLPSYGPYGPYGRSRSSVTYGGLGPAAAGPASLSGAPAKIGSNSIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMG0</accession>
    <name>A0A367LMG0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMG0"/>
    <dbReference type="OrthoDB" id="4158609at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="91" mass="10114" checksum="2B7AB71F4D078676" modified="2018-11-07" version="1">MSEPNQVVPDVSSPSTTGRRSVRTLTPTALQPPKLTNHQSFQSSGILPAFDTLHQHKRGSDVSRRMSMSDQQTKGGIFHQLFHNNFGRNAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMG6</accession>
    <name>A0A367LMG6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_3368</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMG6"/>
    <dbReference type="STRING" id="1330021.A0A367LMG6"/>
    <dbReference type="OrthoDB" id="1162399at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060213">
        <property type="term" value="P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04329">
        <property type="entry name" value="RNAP_II_Rpb7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04462">
        <property type="entry name" value="S1_RNAPII_Rpb7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000043">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF4">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="8">
        <location>
            <begin position="9"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="7">
        <location>
            <begin position="78"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI15634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="171" mass="19189" checksum="7ABF5A9C9A853EEE" modified="2018-11-07" version="1">MFFLYNMERSVTLHPSYFGRNMHELVTSKLLKDVEGTCAGSYYIISIMDTFDISEGRILPGSGLAEFTVGYRAVVWRPFKGETVDAVVYSINQQGFFAQAGPLRLFVSAHLIPSDIKWDPNATPPQFTNNEDTVIEPSTHVRVKIIGTRTEVGEMWAIGSIKEDYLGCLQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMJ7</accession>
    <name>A0A367LMJ7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_3526</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMJ7"/>
    <dbReference type="STRING" id="1330021.A0A367LMJ7"/>
    <dbReference type="OrthoDB" id="5315052at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058925">
        <property type="entry name" value="zf-C2H2_AcuF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35391:SF3">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26082">
        <property type="entry name" value="zf-C2H2_AcuF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="845"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="910"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="588"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="633"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="516"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="639"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI15664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1135" mass="122914" checksum="9F718252879D651A" modified="2018-11-07" version="1">MASAFTLSPTAFGGQEPGPRRNNAPGFPPRRLSVLVPNADSVVFHSAPASPSSGQLRTPLTGSTLGPNYYHHQQGDFGGVNGDPFFGAEFSHTRPGSPSLLDEHLANKIMKTEKPQTTVIDGLSCPMTPGSPHNVSSPRSERRVTLMRFGACPLPDSVSPEQLQTPAHTVSAVDQADWTPDSTVSNRTCDDSLAPAALTLTPLSPRVTVSVWDNDGSVEDAVAATAAETADNCRFGGILVPGDLISPTPSSGFVLGTPVPQALQQDGLATPRVGLDPESRPVDEVPSINDAAAERKVQDRNREVDDWLAQYPADPFSVPDETSVEAIPTVEDLPGQGHDDGIPLGDQTENRFITGQTYYNEAGGGGGMLSQVDREIIASDAKWEDAPMLPHIITGSCCASQPQTSQAAIEKFADMCRDTDSILSRSATWGTRRRSSPSVLDLDLENSRSGSFLKKLGARGRGNGEKGISRAGSLLKDLRGLVSRPSTNSLRKRSRSRSRELAGDGGSPPAGGEQQSASPSRLSPLSPSPTWRGRKQKPTPSINTALASVAHSMVNISTPLPHSASLCLTPPIPSPRTGRASTFGVRASFGRSRSRSDMPRAQLPPARAESHTSLGDLWRRSTGPLLTPLIKTSHFGVGADDEDDEDEDEDEDMYGDGQAIHPNFIDSIPPTVEGFQQHILALNPGLGERHGYLVERIAQQQVGRYKNLLNARIKHLGLGTGCPNGSQCAIVVGSPSPSVDMMPGGGEEGAAAAAAAVEGFIGPESFPRDIPMPPTQQLPAEFECRLCFQRKRFQKPSDWTKHIHEDVQPFTCTWDRCRDPKVFKRKADWVRHENEGHRHLEWWTCDVDDCRHTCYRRDNFLQHLVREHKFPEPKVKTKAAMKRNGGMDPTWQAVEKCHVETSARPQDEPCRFCGKLLPSWKKLTVHLAKHMEHISLSVLRLAAARSKELTADSVISPVLDPAARPPPMMMMMTAAATAQQPQPPFTPGHNVATFHSPSDQPRSFGYPAVAAEEKPTSASLYDQQSYDVPCGIMPTLQGSPPALYRTSPPGEPESYPQQQQLNVMSTPRGAERLMSYEPMMYPGRTVEGQFSGSDPLPSSFSSPMMKTPGGWDTPQTGGFSDSCRLTSPSFFFQNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMN8</accession>
    <name>A0A367LMN8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_3489</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMN8"/>
    <dbReference type="OrthoDB" id="5360701at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI15706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="403" mass="44557" checksum="AC92DCE65A9E3185" modified="2018-11-07" version="1">MRRATARHISDTCSFDRLSSRPPLSLLFSRGARPSIWVPAPARYSSTKNSSTKPSAAPARRSVVPPPPPPGITELADAVQARRKKLLSNDGIPPLQETIDALYLCRKAANALHVKLENAEAQFRASASRLALLGAERTGSQLPMDAKLQEAVNTVSYAAYTIITNPKIEMRADLLGLYVQIQHQLGRPESLPTVLRLYAAKPKPVDKDGKVQLVRQNPNSPSKAVEVDAADLALRTAIEAKHLDSALGIIEASYCTKAFKRQKLLKHATPPFIALATLPFSIYGLSTAYALYCQNTMDVMTATAICCVGITGYFLSVGSLGMIAKLSYKEQMRRVTWTPGTPLRYRWLREEERAALDAVACAWGFKEEFRHGEETGADWEGLKEYMGYRQMLLDRVEFMRGMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LN64</accession>
    <name>A0A367LN64_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Arrestin C-terminal-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_2713</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Interacts with hulA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the arrestin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LN64"/>
    <dbReference type="STRING" id="1330021.A0A367LN64"/>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011022">
        <property type="entry name" value="Arrestin_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF17">
        <property type="entry name" value="FI21816P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02752">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01017">
        <property type="entry name" value="Arrestin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin C-terminal-like" evidence="4">
        <location>
            <begin position="185"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="432"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="546"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="438"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="470"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI15886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="568" mass="62784" checksum="13635211A8A58A2B" modified="2018-11-07" version="1">MPSFNPFSSVTGRNSYSLFDIRLDDDFIVFRGNDHESSGQLLKGVVVLCLSTLLRIEDVRLRLTGTLRLTWTDPRSSTSAVSSQKVDKSTTILDHRWAPFVGVHGKSMTLPAGNYEYPFEFTLPGDTAESVEGIPEASITYRLKATVGRGKLAYDLHAYKHLRVIRTLEPGALELLHAMSVENIWPNKVDYSIVIPHKAVVFGGTINMEMRFTPLLKGLELGEITAKFIELRDCWIQGSTGLSLREHHTEREVSHWKFVVNHEDHWHDMIDDTGQEGWTLKKPLKLPKRLRQCIQDLNHHGIKVRHKIKLTVALKNPDGHISELRATLPVSIFISPNVPFDEQGNLMRQSPGSTLAGQDAATMAPPGYGDHVLDQLYEDVEPVGLQTPGVQSGVSSPFYAHSRAGSTENLAGMANSSPIAPAALSSRLADVSLDSPRRNSSYTSMHSGSGRMSPNAVRSEPPSCSLTRSNSREDPFRRNSADQVEADEVDFADLNRVPSYATAVRTPARLRTQTSNFAVPDYQTALHAPRTPPGTEMAPEQLTTIPEVTPSVPPEPGEQPERVLSPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNB8</accession>
    <name>A0A367LNB8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_1760</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Involved in pre-mRNA splicing. Facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome. Binds to RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLT11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNB8"/>
    <dbReference type="STRING" id="1330021.A0A367LNB8"/>
    <dbReference type="OrthoDB" id="10259600at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12265">
        <property type="entry name" value="RRM_SLT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000396">
        <property type="entry name" value="Putative Pre-mRNA-splicing factor slt11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034356">
        <property type="entry name" value="Slt11_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048995">
        <property type="entry name" value="STL11/RBM22-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF6">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21369">
        <property type="entry name" value="STL11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="224"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="187"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="318"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI15909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="363" mass="39710" checksum="AAB9C0705E50F4B6" modified="2018-11-07" version="1">MPPQIKKDLNRSGWETTDFPSVCENCLPDNPFVKMIKEDYGAQCKLCTRPFTVFAWSTDRAQGRKKTTNICLTCARLKNCCQGCMLDLSFGLPIAVRDAALKLVAPGPQSDINREYFAQNNEKLIEEGKVGTEEYEKTDEKARELLRRLATSKPYFRKGRTVDETEARVSDASGGSTGVGPIRTRASRAAGRTKAGKGRLAFPSAAPTAPTPRDWLPPNDKNIMSLFVTGIEDDLPEYRLRDFFKVHGTIKSLVCSHMSHCAFINYETREAAEKAAAACQGRAVIAGCPLRIRWGQPRAIGTMDKEERGNMLRDARVPRARGRDGQWAAIEGGAAQEGPEGPDAVPAPPGTGDGPKYSSLAGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNU7</accession>
    <name>A0A367LNU7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_2339</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TCP11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNU7"/>
    <dbReference type="STRING" id="1330021.A0A367LNU7"/>
    <dbReference type="OrthoDB" id="276323at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010737">
        <property type="term" value="P:protein kinase A signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008862">
        <property type="entry name" value="Tcp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832:SF11">
        <property type="entry name" value="LD23868P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12832">
        <property type="entry name" value="TESTIS-SPECIFIC PROTEIN PBS13 T-COMPLEX 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05794">
        <property type="entry name" value="Tcp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="108"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="564"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="700"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="564"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI16090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="762" mass="84494" checksum="C848F912526B874F" modified="2018-11-07" version="1" fragment="single">TALPRSLSLIFIRRRLDRLRTTPHVFLLLLPSKTPTASSGPPPSTAKPCLPLQRILRPPVAPTIHLWHTRGKRLGTKRLEPQKANLLVCCSSISGYFVLAIMEQGFGRGPVERSRRSLSTSAPVPKGEGEPINDADVQMQQPPPPDAETKAISPSSQESPRRCEAAVRASSPASAAMSRSGSSSTHASTPPVDVGTHRRSSRHSTPQPGPVEPPVTRSTLSELDVSKIIHNPKLRHDINFDPELHFRPNLDGEKGRKKQDKANFFWRTLKEELTDFLTDRDSFVAKHAKRNDWTLPALLKAVKEIIQTLVPQRDRQFLEEGLNVELLMQQFYRGVADLEKLAQWLSHVLKSHCAPMRDDWVDTMYAQLSSGNRNADLEELVTGMRSLLSVLEAMKLDVANHQIRCLRPVLIEDTTHFEQKFFLRKMQSKKVDTSGARRWYADAERRFASSSSSSSSSSHLLGDMAVFFDALSELILPSTAVKRVPSTFLFDEERILKLRSDMLDAINLEVCMRMYEDLDRVGRFSSSILRGASRALDEETLNRSPSPMHDFNFNAPFPPSRPSSVVFSSASSSPRSSLTMPSYVAPSESGEDRARSRTVYGTLVALLQSATPTSRPFARWQELAPAMALQIFRYTSAPSEMLAAFEAKLAENVCNADSQLYLEVEQAFHGRLMTELAARVCEFKSLSGLSLFAVATGARLQSGGGGGGSSVQSGRDRDGEGSDEGGVEDMATRVAHLGVLHWRVWSQLAYVSDEMSMDSNQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPA8</accession>
    <name>A0A367LPA8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">T-complex protein 1 subunit epsilon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_2809</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPA8"/>
    <dbReference type="STRING" id="1330021.A0A367LPA8"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03339">
        <property type="entry name" value="TCP1_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000003">
        <property type="entry name" value="T-complex protein 1 subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012718">
        <property type="entry name" value="Chap_CCT_epsi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02343">
        <property type="entry name" value="chap_CCT_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI16221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="551" mass="59818" checksum="1DD625BD97D557C5" modified="2018-11-07" version="1">MSLNLDVSNATVMKDEQGRPFIVVRDQGKKKRQYGNEAVKSHILAARTVANLVKSSLGPRGLDKILISPDGDITVTNDGATIMQQMEISNHVAKLLVELSKSQDDEIGDGTTGVVVLAGALLEQAADLIDKGIHPIRIADGYDQACDIAIAELDNISDTVDFSRDQTSNLVKVARTSLGSKIVSKAHDQFAHIAVDAVLSVADLERKDVDFELIKVDGKVGGSLEDTLLVKGVIVDKDFSHPQMPSEIRDAKLAILTCAFEPPKPKTKHHLDITSVEEFKELQNYESKKFVEMIQQIKDTGANLAICQWGFDDEANHLLLQNKLPAVRWVGGPEIELIAIATNGRIVPRFEDLKASKLGTAGVVRQMSFGTTREKMLVIEECANSRAVTVFVRGSNKMIVDEAKRSLHDALCVVRNLVRDNRVVYGGGAAEVACSLAVEEAAVKTPGLEQYAMRAFSEALDAVPMALAENSGLNPISTLAEVKSQQVKAEGEGRGKLGVDCMGRGSNDMKEAFVIDPLIGKRQQLQLATQLCRMVLKVNNVIVSGVDENDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQG1</accession>
    <name>A0A367LQG1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQG1"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016801300" evidence="1">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="62" mass="6917" checksum="F5BECB889E66D8C4" modified="2018-11-07" version="1">MDAVGRRRLVFSFLLSSGYLLVLHNKAVSSEAKEDGRGRASSPSHMQKLRFTPFILLVIAIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQG8</accession>
    <name>A0A367LQG8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Carboxypeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_2687</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQG8"/>
    <dbReference type="STRING" id="1330021.A0A367LQG8"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF404">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016735851" description="Carboxypeptidase" evidence="7">
        <location>
            <begin position="20"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="539"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="541"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI16686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="674" mass="72173" checksum="2597CA0873A90CC5" modified="2018-11-07" version="1">MLLVFVSLCLLAALAACSADDDQPLIVVRSPGDPGVVVSFKRQSRNLCTTAFKDQKQYTGWASIPGEHPTNLFFWFFEARERTESLTIWLNGGPGVSSMVGLFQGLGPCEVVETGFGQYETFAREWGWDRTSNMLFVDQPNKVGFSYDTPSNGTLSFIKNSIIRPPISTDGAPLAWAFVNGTFSNSEARSTANSTSAAAMAVWHLLQGFLSALPGYQPALDAPVGLSLFCESYGGVYGPVFAEAWEKQNEKRRKGVLDPKTTLELRLTSLGIINGCVDSLLQMPSLPTFAARNTYGIKALSDVEAELYLAKFSAKGGCAELLTMCQSVSSWEDGGDLSVAESHCRDAVDVCGKDVENPYYNSGRSPYDIAGRLAYPLPSYLFTDYLNQPSVLRALGSPVNFTLHSEIVSNNFLATGDISKGGNIDRLAALLRRGVRVGLVYGDRDYICNWIGGETVSLAVALRAGGSYAFNFPAAGYAPIVVNSSYIGGDVRQFANLSFSRIFQAGHSAPWYQPETAFQVFARIVRGLSVSMGRPMDPFTYRTTGKPNSTRTDKAPEAPSPTCFVRAFAVTCDDEALMLARTGGGIVINGILYKKSEDWPLASSSLSSLSLSSSSSRGAAFVAAATSSIKTSSPPVVMTGVYVATETPSGGGAACSVPAWGLGLALLLVVSRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQL6</accession>
    <name>A0A367LQL6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Pre-mRNA-processing factor 19</fullName>
            <ecNumber evidence="16">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">L249_2492</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 16">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the WD repeat PRP19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="16"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQL6"/>
    <dbReference type="STRING" id="1330021.A0A367LQL6"/>
    <dbReference type="OrthoDB" id="687049at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070534">
        <property type="term" value="P:protein K63-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16656">
        <property type="entry name" value="RING-Ubox_PRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000027">
        <property type="entry name" value="Pre-mRNA-processing factor 19, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038959">
        <property type="entry name" value="Prp19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013915">
        <property type="entry name" value="Prp19_cc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055340">
        <property type="entry name" value="RING-Ubox_PRP19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43995">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43995:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08606">
        <property type="entry name" value="Prp19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13 16" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5 16" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="12 16" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="14 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="11" id="KW-0697">Rotamase</keyword>
    <keyword evidence="7 16" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 16" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4 15" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="U-box" evidence="17">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="15">
        <location>
            <begin position="272"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RCI16745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="477" mass="50841" checksum="9840BFF52717BBAE" modified="2018-11-07" version="1">MLCSISGESPQEPVVSKKSGFTYEKRLIEQYINDHGTEPGTGQALTVQDLLPLKGSAIVRPRPPTLTSIPALLATFQNEWDALALETYNLKEQLARTREELATILYQQDAAVRVVARLTKERDEAREALSKVTVGGGPADGEEMVVDSVEALPEELAERVDETHKRLTKGRKKRPIPEGWSSADDISALETVASTSLTLSHPTCLDLEQEHAVMGDSKGEAVIYSLQAEAVERQLPIGKPITDTLWAGTKLFFATGQGDVKAYEGGKEIASASEHAGPATALSAHPSGDILASVGADKSIVFYDTGSMKRVGRVFTDNSLNRCAFHPDGHLFAAGTVSGDIKLFMTKTLEQAAVFSLGAPIQAIAFSENGFWLAATAKGQSIVTIFDLRKDGDAATAKVLETGGPVQSLAWDLTGQFLATGGTGGVTVQHHAKSSKKWSEPFRNSVSAVAVRWGPSAKKLVAIGEDGVVAVYGVKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQT8</accession>
    <name>A0A367LQT8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glucosidase 2 subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L249_2551</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQT8"/>
    <dbReference type="STRING" id="1330021.A0A367LQT8"/>
    <dbReference type="OrthoDB" id="28322at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036607">
        <property type="entry name" value="PRKCSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028146">
        <property type="entry name" value="PRKCSH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF14">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12999">
        <property type="entry name" value="PRKCSH-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13015">
        <property type="entry name" value="PRKCSH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016860272" description="Glucosidase 2 subunit beta" evidence="13">
        <location>
            <begin position="22"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="602"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="669"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="704"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="736"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="776"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="915"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="944"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="986"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1013"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="15">
        <location>
            <begin position="418"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="14">
        <location>
            <begin position="603"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="388"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="544"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="806"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1053"/>
            <end position="1072"/>
        </location>
    </feature>
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        <location>
            <begin position="178"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="389"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="554"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="565"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="811"/>
            <end position="846"/>
        </location>
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        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCI16710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1072" mass="115650" checksum="6CC0203CBB9C5E8B" modified="2018-11-07" version="1">MLNRRCSWALLGAFSVLAAAGQLPRGVGPEFAFHYDGSSSEFGCIGDPSVKLDRGRINDNSCDCADGSDEPGTAACAFIDALSPEQPLPGTSSGSTNATRALPGFWCKNEGHVGAYVPFEYVNDGVCDYDVCCDGSEEFGGRVVCENRCAVIGKEHRKLEEQKRLGRERALKKRAIMVAEASQLRRRAESRLAQLAGEIKTAEAQRDEAKRNLAEAELADRNRVVSGGGGVGGKLGVLVELARKRVEELRSSLDAVRQHRMTLQSEVDELKAILSTLKTEYNPNFNDEGVKAAVKAYEDYAARDGAAPMPELASDDEVNELIKEDSADSGINWGEFEQQTEDTDILLSLEAYLPESLRKAIRGRMVDLRLWLVRNGIVAEKVSTGSESRLVKAAREAADTADRKVQDKTKEQEEQRTDLGKDYGPSDVLRALRGRSISIDSGEYTYELNWLGQTFQKSKKGHGDTNMGEFTRIDREAADEEERIDGKSLGKGMRMVLRYEDGLGCWNGPRRRTDVWLACAETEELWRVTEAEKCVYKMEVGTPAACDGGEEKEEEGKKKKDELYTTDQLQSASPKGESRSPQLDAQSPKSLRSTMNNNQLKAIAILLSIGASAWGTSIGIVAPLLVSLDKSSSSAIGRGSITAAYYLGALPSYLLLGPRLADRYGRKGGLLVGTFLLCMGGVIVFVACAAGGRGWTTTTTMLLLGRWVTGIGCAVVSALVPLYGSEVAPGRHRGKMVTASHAGFVAGIAVGLWIGAGFHHRRYSGGDDDDVRGSSLLALLPLTPASIFATGIFFFAPESPRWLTQQQQQLSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSKPLLLRAFTLQLMSQLCGATAAKYYLPQLLHNLGVPTRTALFAGAAEMTAKLLMTPLDMWAIDTLGRRVCLLAGCLVMAFSLLINGTLPLLYPRNSSSLADAICVAFIFIYAFGYSFGLGPASWVYSSEIFPTPVRARGLNWAASGGALGSLVVSFMWPIGLAHLGSVVFFFFMAFNLACVPIIYFFYPETKGRELEDIDALFAGRQPTGSEEEDAPLLPAERTAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQV9</accession>
    <name>A0A367LQV9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3031</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQV9"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="143" mass="15648" checksum="F4EFA836191F88C1" modified="2018-11-07" version="1">MPSPITAADIILPTDETHEIGHDAKSENRRESPKSARQLDCMLEEEARSSPCFLSRHALTEPLCLDPTAIKSINILERGQSMTANNAYDRTSAGVPPPTAYNDNYMMCTYAGVPDVTSLGLWLSCNIKGRPTLQSHSAYSAHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQX9</accession>
    <name>A0A367LQX9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sphingolipid delta(4)-desaturase</fullName>
            <ecNumber evidence="8">1.14.19.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_1889</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Delta(4)-fatty-acid desaturase which introduces a double bond at the 4-position in the long-chain base (LCB) of ceramides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an N-acylsphinganine + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = an N-acylsphing-4-enine + 2 Fe(III)-[cytochrome b5] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:46544"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:31488"/>
            <dbReference type="ChEBI" id="CHEBI:52639"/>
            <dbReference type="EC" id="1.14.19.17"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.17" evidence="8"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQX9"/>
    <dbReference type="STRING" id="1330021.A0A367LQX9"/>
    <dbReference type="OrthoDB" id="200948at2759"/>
    <dbReference type="UniPathway" id="UPA00222"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042284">
        <property type="term" value="F:sphingolipid delta-4 desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046513">
        <property type="term" value="P:ceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03508">
        <property type="entry name" value="Delta4-sphingolipid-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011388">
        <property type="entry name" value="DES1/DES2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013866">
        <property type="entry name" value="Sphingolipid_d4-desaturase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12879">
        <property type="entry name" value="SPHINGOLIPID DELTA 4 DESATURASE/C-4 HYDROXYLASE PROTEIN DES2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12879:SF8">
        <property type="entry name" value="SPHINGOLIPID DELTA(4)-DESATURASE DES1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08557">
        <property type="entry name" value="Lipid_DES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017228">
        <property type="entry name" value="Sphnglp_dlt4_des"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01269">
        <property type="entry name" value="Lipid_DES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="56"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Sphingolipid delta4-desaturase N-terminal" evidence="10">
        <location>
            <begin position="16"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI16856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="368" mass="41777" checksum="92BE60B1CB892716" modified="2018-11-07" version="1">MVSKSASSSPPPTSFPDHHDFFWTYTEEPHRTRRLAIIKAHPEVTKLCGPEPLTKYLVFSVVALQLLMAYLVSETAFWSFRFWAAAYVVGASANQNLFLAIHEISHNLAFRRPLANRLLAVFANLPIGVPYSASFRPYHLTHHKSLGVDGVDTDLPTALEAVVLDSLLGKAFFCTFQIFFYAIRPMAVYRIPFTWLHAFNVVAQAVFDFALVRFVSPTALAYLILSSFLAGSLHPLAAHFIAEHYVYDIVSHIQRSETDVKNDDDNAASCPVPETFSYYGPLNWLTYNVGLHNEHHDFPAIPWSRLPALRAMADEFYRDLPCHHSWSYALWRFIWDDSVGITCRVKRENARGKRPAAAGRWKESEVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRP6</accession>
    <name>A0A367LRP6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_2124</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRP6"/>
    <dbReference type="STRING" id="1330021.A0A367LRP6"/>
    <dbReference type="OrthoDB" id="5876363at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15534">
        <property type="entry name" value="PHD2_PHF12_Rco1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052819">
        <property type="entry name" value="Chromatin_regulatory_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47636">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47636:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="614"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="64"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="279"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="875"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="992"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="329"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="353"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="464"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="480"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="541"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="569"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1007"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1028"/>
            <end position="1037"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI17088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1037" mass="113281" checksum="45992159B3DCC0C1" modified="2018-11-07" version="1">MISSNTRASRSASRYSSPAQPGWGGSGGNEGSRALMARWLEPSVQSKTSFEEAGLMRYGVLENMAPLGTMPKSKRATAPVEGPRKIILRPSAKPTPQLSPAPPSPQPPAEQAKAKAEQSQELDTTRRRRSTRASLPSRKLRRDEETPEASVIMAKTPSPPSKKQRLEPEEREFTDKVVEAAVDEALRHYRYPTAWALRTLYDERCDDADFVAMVDDVFRQTADAETRNRFGRLVEAKKREGKRDNQGCYYFVPPTTNSRFSPHEAKPAPYAALLLRRCPDDENHDNKNHDGDETDVTEERAAKRPKTCSTGAVVMVRTPRSSKVGRRNSASSMSSLSSAMSLSSPEERGISPVEEEEDEDEDEEEEEDEEEEDEVVVEVEEKEQPEAEPKRHQPPRQGSESNSPTLVRRTTRARRAPPPMAADGEEKETRSTSPDDDAFARRRHARRVTNGHGVRESAVRPILATPPPPPASGPAPAPASAPASAPVVSVSAAAASASSSAAAASRRPRRIVVAPPTTRATRSANKRRPSVESPAAFSWQVDDDDDDDDDDADDAAAAADGSRAATPRPAKKQRTGLRVKTSPVKKKGGTAAGVPRPVADAAGAANKDHTSDNDEYCSACGNAGDVVCCDGCPRSFHFECVDMAQSDRLPDEWYCNECLIRRFPSRVPVHKGIFASALNNLEKCIPRAFSLPAKVQNRFEGVKAGADGDYEEVIPPKTTTTKKRPGYDELPDFFKQREDGRAVLCHACQKPATAGVRAIITCSACPFHWHLDCLDPPLAVPPVLKTWRCPAHMDDMLLEVPSLAPAHRFRRIKGSQPLTPAFARGLKNNGHIEIDWSDEVDRSGWPDASSFGRTYKLASNGVVLDFIEQLRHQGAGYGPRRRESRRVPCPISSQPAHDGPLAGSTLQRSVEEMQVSLTLVSLREKPTEGIEQLTSALLSVADDNVLALMAKTNADSVAKRRLSPSDRQGLGALLAQMEAMGDRIRSMLDEDEKACPASGDGVVPTAQRQQQQQQQQQQAEPTPPSTVDHAEGSMDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRQ0</accession>
    <name>A0A367LRQ0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mitochondrial import inner membrane translocase subunit TIM22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_2108</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the TIM22 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LRQ0"/>
    <dbReference type="OrthoDB" id="75343at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042721">
        <property type="term" value="C:TIM22 mitochondrial import inner membrane insertion complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039175">
        <property type="entry name" value="TIM22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI17126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="300" mass="31095" checksum="B6E00ACF2ECC9885" modified="2018-11-07" version="1">MNSPLGAPSDGNGPQLGASQDPSVRAVQAAMESCVGKSVMSGVMGFGMGGLFGMFMASMSYDTPFGSPVTNAAGQNMSDMPLRQQLKVGFKDMGSRSYSMAKNFGKVGALFAGIECGIEGLRAKNDLGNGIAAGCLTGGILAKNXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXKVGFKDMGSRSYSMAKNFGKVGALFAGIECGIEGLRAKNDLGNGIAAGCLTGGILAKNAGPQAVAGGCVAFAAFSAAIDSWMRQPKEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRZ8</accession>
    <name>A0A367LRZ8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_2161</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat mio family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRZ8"/>
    <dbReference type="STRING" id="1330021.A0A367LRZ8"/>
    <dbReference type="OrthoDB" id="341486at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001167">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037593">
        <property type="entry name" value="MIOS/Sea4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049092">
        <property type="entry name" value="MIOS_a-sol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031488">
        <property type="entry name" value="Zn_ribbon_mio"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453:SF9">
        <property type="entry name" value="GATOR COMPLEX PROTEIN MIOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453">
        <property type="entry name" value="WD40 DOMAIN-CONTAINING PROTEIN MIO FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21719">
        <property type="entry name" value="MIOS_a-sol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17034">
        <property type="entry name" value="zinc_ribbon_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="MIOS-like alpha-solenoid" evidence="6">
        <location>
            <begin position="550"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="domain" description="GATOR2 complex protein MIO zinc-ribbon like" evidence="5">
        <location>
            <begin position="1014"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="930"/>
            <end position="973"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF21719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI17189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1103" mass="122261" checksum="0D940B7CBB0483E6" modified="2018-11-07" version="1">MDRPEPGLVKWSANAAVDSFVHINLQHRVVQLYKPTGYAHKRRFDHVKLSRHDDFPPLTTYDWSAAHPELLAVGTSSGIVNLLRIDDNSNAYVEIGLKMARTCQAVAFNSTGLLAVGLDRVRMDQSLQIWDVNRLSASENLNKGFPPFAATFVEPRLRLEPSVSVSSLKFFEDSPQTLVAGIKGQGLRIHDLRDATSIVTFQTRCNNNLAIDYADPNFFASSALDHPGVMIWDRRVTSRPLASHTYLQAVEEDDLPWGGALRLNKVIETSPDLFLTEGKHSIIRSLRYCRDRRGLLAALSPTGQLKVLETNREMQPSGTAPQGAPELLQVQRSHEMDVSYRDTSRRGHRIVSFDWITLGSPALRPRLLVLRANGSFEVLEQPSRTSDYVFNFVPWQSPHRGLHEAAPYHDVMRFEPSQTVEMLGTFLAEQALSEVPIFGSDKCRIEERLQGALKNTSTVSTIVEHVDENPTPLPDSFHKATSVASKLRSLRAYVRDDNGSAQAEDDDANDMSLASNSLTSCREIHEGLLSSLATAKGLPREAQSVVDHVMLSRAKEKYLFDAAVNREVVSDDPWKRFLWDWIADAERAAEGGGMLLGNIDLSFLGAHAIWTNDLGEETLEGKTPSTRLAPGTGVPDASQWERLIGQYCKKRRLPRFDGVPTKKSHHRQLCLEICGWGDPRRRDGDGPASTEHPTAMHHTMVASRALFRGDTKLAMEILKRASSTHPELLFVSLALQLTTGRGGKQAAKEQLEIDDAVASKTDPYLRAISSLIATGDWSTVANQRSLPLADRATAAFRNFDDDQLTRWLGQQVRLASEEGDIEAIVLAGVSDSLVDVMARYVQKFNDVQTATLVLSHCHPRYMDDVRCRAWRNAYRSLLQRHRLFLHRTRFEVESTKRSKRDGVPTLRPPSRQMALRCVYCDAETALANQQRQHQHLQQPDAAVIPAPPSSSSATTTATSTASTTTAPINTNTTTTTTTTAAAAATAATATAAAAAAAAAPLETRNPLLATTINAGVSCPNCGRHLPRCVVCLEVVAVPRSDRPRDRDRDDGGRAGRFPTFCLRCEHVLHLDHARQWFARHVECPVPECRCLCNFKANPELAYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LSB8</accession>
    <name>A0A367LSB8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_2285</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LSB8"/>
    <dbReference type="STRING" id="1330021.A0A367LSB8"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000055">
        <property type="entry name" value="TBC domain-containing protein C1778.09"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000023">
        <property type="entry name" value="TBC domain-containing protein C1778.09"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="508"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="472"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI17287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="770" mass="85615" checksum="4197ACA03D72726D" modified="2018-11-07" version="1">MTRSADTGLVALRYEKTKAAEPPVPLPPTTRSLPRASSTSRSSLSSSSSPPPPTTTTTTTTSQAPLAHHHHHDNHNNNNNSSNSPVVVVVPPIPMPTMPMPPAEQHPALRSPPAASLDDEWKRDSGHAAATDESKRLSHERAMPTLPKRGPPSSSSSSASPPPPNDNPPPFSPLAIRIPDDDFMAGLSFSNRGSIIMLDGSKSPPTPDVRLLPAEVDMESQKVRLLYESVKWDDGSARHSFCDRLEPTPEEAVAQPPSSSCGPPPSLYLSQPHPHPQRQQQQQQQQQHLSVNSSNRRRDTELAGGLEDWEDVDGADVDRYGFISAPRPPASRVSTPTDLWSAQLSPRRRNVLHKRDPILGFSTAVGRMPSRKVSARSLNTQNSELSLASIRSSRSVLRQAGNLLPGNRNRRWMDEAGDMLTVSPSLQDMLEEAHVDSISETLKRKEWDRSEKWRRMAKVLRRADNCGDDGDNNNNNNNNNDNSSKDPQGAGFDFDVTSPKLVERTWKGIPDRWRAAAWWSFLESAARRRPGSPSAEELTAAFQALQARSSPDDVQIDMDVPRTINRHIMFRRRYRGGQRLLFRVLHAVSLYFPGTGYVQGMASLAATLLCYFDEEKCFVMLARMWRLRGLERLYQPGFEGLMTALREFEGGWLAKETAVKLTELGVETTAYATRWYLTLFNLSMPFAAQLRVWDVFLLLGGDGGDGDGSGLEILHATAAALVQALREVLLDADFENAMKALMSWIPIKDEDLLMKVVKAEWKMHRGRRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LSJ8</accession>
    <name>A0A367LSJ8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_2670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LSJ8"/>
    <dbReference type="STRING" id="1330021.A0A367LSJ8"/>
    <dbReference type="OrthoDB" id="2687876at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06293">
        <property type="entry name" value="Kdo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI17391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="279" mass="31252" checksum="0FB5AA3706C29169" modified="2018-11-07" version="1">MCDNSLDDAQLAIRCPLDNMRRAHDKPRATPWASSTSFRQSYCFRHVRGSQHRTLEPILLGELFLPFPPGDWNKGHVDRNPDTGEAVFVSTEEVQLAGVGNIWHPVKLDELDLTKQDGVDEKVHFDQRIHVTTHLQLNGGKPVLFKLAVWPWEVPWVEDETAAYQWIKGGGIGPQFQGHVTEGKEGCIIGFVIEWLEGFTVAGPGDMDGCAKVLGRLHELGIKHGDVNKNSFLVRDGHEVVLIDFEATKRDCPAAELEEEIKVLVESKLEGPNRVEYCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LT16</accession>
    <name>A0A367LT16_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2261</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LT16"/>
    <dbReference type="STRING" id="1330021.A0A367LT16"/>
    <dbReference type="OrthoDB" id="9994419at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051341">
        <property type="entry name" value="Zyg-11_UBL_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12904">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12904:SF23">
        <property type="entry name" value="PROTEIN ZER-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="24"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI17352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="602" mass="66988" checksum="02CF087083571BDD" modified="2018-11-07" version="1">MATANGTQPSRVSVKPRPVREFSPSDVGSRSSFSSVRENDDGLAQTFTRSKVSSYIDAPEPVFDESPSAEKADFSFRPPLTQPHSRLHGFWFPSDSFRGWKHIPIKGRRVSRSCEDLHKLLVMWDHVSPVKNKSRLSHAVGLSPLETLPAEVLGAIIDLLVVEIPPNGLTTRNADLMAILLTSRSMHAATLDVLYRHITIPHSRIFRKFLTTIDMYPALATIVRRLDFSHFNPSMIFSTASERAQTQNLTSETLARCLELTPHLQELLAQEYIDDDLSPHVLAKLLFDMPQLRALDLCGCSSPAFKDSFMSVLARPWPDALSITKLSLHKCLSLPSSVFETLLPRLPRLTHLDVAGTRITDQALEAIPPTARLTHLNLTKCKELSSEVVVKFIKTHAAAVDSLVFLSLATDSVHHLLLGKDDVDALLPHLPPTLRSLNLRGSRMHSSHVPALARLCRSLEELAVGRGLDMNDVLCLFKQQQEAVGGGCFSAHSLCYLDISDLDTVIGSASALLAPESAPLHVIEIEERAYERAAKLNRNFDKVGWAATEFGSRYWLVRKPSGHNHQRRWWKMGVESWGMRKVPVATAEVGGMYGSFMFGRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KYZ7</accession>
    <name>A0A367KYZ7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_1367</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000031">
        <property type="protein sequence ID" value="RCI07399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KYZ7"/>
    <dbReference type="STRING" id="1330021.A0A367KYZ7"/>
    <dbReference type="OrthoDB" id="3357002at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35184:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35184">
        <property type="entry name" value="YALI0C10208P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="379"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI07399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="423" mass="45579" checksum="3A80FA15049E1C61" modified="2018-11-07" version="1">MQTNFGHTLRPAAPMAFPRLLAVSSTGMPGLMSPGASSPTGAPDPLHGPVLGGEPTGTGDVILTAFFLALFALGAFTHMSIYRANGRRGHKFIMSLNMFQFCVIRVITCVFRIAWVFSKLRGVVLFAQLVQSAGPVIIFAINLVFAQRILCAMHPAIGWHPIVRKAFLFSILSAVAVTVIGIISLSVFFFSVDNLERHEMTRKLLVFGGSWNTMISLLPLIVIFGCATPGPPAEQFGQGALITKATILVFVAALAAAGAAVRLAVALNPMGGLLGISLFDRSVFYITGFTFEMLTVAIFAHFRVDLLFHIPNGSSKQGDYAAGAKRPAKGQPWTVSELEREFAGLGIRYDRLQSRWGARGDQILLRFYPTLNSKGCQGTASSANPTSSSARTDDDDGRSIPDIYGLERDTFELGEVASQSIRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZ93</accession>
    <name>A0A367KZ93_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000028">
        <property type="protein sequence ID" value="RCI07491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZ93"/>
    <dbReference type="OrthoDB" id="5552418at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI07491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="360" mass="39753" checksum="2CBC7084268B0C15" modified="2018-11-07" version="1">MDDPSRGRRQYEPPGQRPSNQRYQVPITSPQGTSFSGERYRPPTLNTSPPTPRSINVAGNYNSYYQESQAATFSTPNMSATAMAYGADYGSDTRGQGQSFGNYNAGMMMYNVPQSGTQTPVYDTQTFTQRQPAAMPIMAPDVVASTYFGSEPGAAAASMQQTTTPQGSAAPSAEYHHAQGAHMGYAGNINAMQQQAPAEGQDYRDAALEQKWVSYQRRLGTVFQDVKNGSLESASETLLSLSNWLLTQVADLGLSQDDASLHDERIKLWNDFNHAWLALGFQQKQLMQTGQQVSRAQTLMSESTIKKMGDELVRLCDGVERHGLVDYQYGVWEEQIESSKYLLRQGLGEEDENEEANART</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZA6</accession>
    <name>A0A367KZA6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_8338</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000027">
        <property type="protein sequence ID" value="RCI07505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZA6"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI07505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="57" mass="6726" checksum="5202CD29813EEDBC" modified="2018-11-07" version="1">MIFFMVMPALIGNIIPRRPVAQKNTQQMQNYTTLEFDTSSVTRKEDQISMPNIYPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZE3</accession>
    <name>A0A367KZE3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_1649</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000026">
        <property type="protein sequence ID" value="RCI07537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZE3"/>
    <dbReference type="STRING" id="1330021.A0A367KZE3"/>
    <dbReference type="OrthoDB" id="1093at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054179">
        <property type="entry name" value="PSD13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035298">
        <property type="entry name" value="PSMD13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040798">
        <property type="entry name" value="Rpn9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22037">
        <property type="entry name" value="PSD13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18261">
        <property type="entry name" value="Rpn9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="183"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="136"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI07537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="397" mass="45444" checksum="3CFCC84E4EDF1DC6" modified="2018-11-07" version="1">MNVETIPEFLAEQRDKAPEQLQSLVLDFENLWERKLWHQLTEALVQFFDHPDSAPQRLPFYKTFIPNFADKINQLKLVDLALKAGTQCKGMFPRGGGGPARGFVYDQERLEFLQSVTRRVDKETSQDSLVFASVAVARVKLNLNELDEARKDLDAAERILDSFDSVEAVVHAAFYDANASYYQRKMDYANYYRTALLYLACIDLSSLSAEERHCRAYHLSVAALASNSIYNFGELLLHPILDALAQSKEDAWLRELLFAYNRGDLDGYDRLSNNITSNKLLSEHSSHLQQKICLAALTEAVFRRPPHDRTMTFATISRETKVRFDEIEHLIMKALSLGLLRGTIDQVDKIAQISWVQPKVLDMKQIRNMRQRLLDWDANVNQLGNWIEAAGKDVWAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZS2</accession>
    <name>A0A367KZS2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_5756</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Luc7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000024">
        <property type="protein sequence ID" value="RCI07675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZS2"/>
    <dbReference type="STRING" id="1330021.A0A367KZS2"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004882">
        <property type="entry name" value="Luc7-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12375">
        <property type="entry name" value="RNA-BINDING PROTEIN LUC7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03194">
        <property type="entry name" value="LUC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="228"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="243"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI07675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="268" mass="30325" checksum="FDBC307A92917FDE" modified="2018-11-07" version="1">MAAEQRKLLEQLMGSSSTSRDAQLSLDDPKVCRSHIAGSCPHDLFTNTKQDFGPCPKVHSESLKAEYEALSDREKQRHGFEYDYVRDLHKYIDDCNRRIDAAQKRLEKTPEEIRQTNDLLESIADLEENIKGGILEIQLYAEQDLVSAAIDEWFNLKSMLQTKAEKERDLKSLSDTSGPSGHQKLQVCDVCGAYLSRLDNDRRLADHFYGKMHLGYAQMRKALDSFPKEMKSRARQQPMMDGEGPGGSRGPKGSGGYRPYKGGGRNHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0J2</accession>
    <name>A0A367L0J2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar protein sorting-associated protein 26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5868</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000023">
        <property type="protein sequence ID" value="RCI07931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0J2"/>
    <dbReference type="STRING" id="1330021.A0A367L0J2"/>
    <dbReference type="OrthoDB" id="3821113at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000004">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000010">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028934">
        <property type="entry name" value="Vps26-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12233">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 26 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03643">
        <property type="entry name" value="Vps26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI07931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="37105" checksum="1FAB600513EB500F" modified="2018-11-07" version="1">MSYFFSTPVDIDIVLEGADERAMVDVKLDKNRREKAPLYMDGESVRGAVTVRPKDGKRLEHTGVKVQFIGTIEMFFDRGNHYEFLSLVQELAAPGELQHPQTFEFNFKNVEKQYESYNGINVKLRYFVRVTVSRRMADVIREKDIWVYSYRIPPEINSSIKMDVGIEDCLHIEFEYSKSKYHLKDVIVGRIYFLLVRLKIKHMELSIIRRETTGAAPNQYNESETLVRFEIMDGSPSRGETIPIRLFLGGFDLTPTLRDVNKKFSTRYYLSLVLIDEDARRYFKQSEIILYRQAPEALPAPEAGIQALPAPNESKLAAVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0Z6</accession>
    <name>A0A367L0Z6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_6279</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0Z6"/>
    <dbReference type="STRING" id="1330021.A0A367L0Z6"/>
    <dbReference type="OrthoDB" id="6287070at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF722">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="139"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="328"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="664"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="328"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="358"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="383"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="672"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="708"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="754"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="812"/>
            <end position="825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI08095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="861" mass="95496" checksum="625CB784346C6952" modified="2018-11-07" version="1">MKEFPIKFLTLRDKNGSHHRSKSVPATKTRPISADAFKALFKLDNTRKQEVAREIEETKVRPSFRKRQGFLPNRKPQFKQIHRRLDQLNITGVSSDHIRDIMATKFVDGDPARAAIFIDMEQRAQAGIIVSHDPSVRLLGAENRGGVTCYLDALLFAMFSKLDAFECMLSNDFPPDTPTYRLVNLLRIWVNMLRSGNLIHSDLVRRRFSSPPGWLVALTRPKTKLIQEALADCGWPDARRLEQQDTSEAFAFLTETLQLPLLSLQVDLFHQGKRDDDDHKVVFERLLNLAVPPDPDGKGVKLEDCLEEYFNARVDVLRDSEVSRKSVLEDRTMNDRPALSHHDTIRPTSNGEAPKTMATMTKNTSTPASPSSELAENSLCRLNPNTSTGTSHTGSAFDRNAIFSKGDEKASGSRKNLHSRERSIGVIRRVLVDDQGRPAEDSSSTQTIERKSSSIIKAVTIPAWQFFRLIPWHTITNNEPQNDREVAMNFDQRPIVGICLKRYAMDPSGRPQRLNTFIDIPDSLRLPHFMLAGGPELEEEDGLNTEYKLVLQSVVCHRGDSLQSGHYISFARVAPKLLTDNRRHDVDPPPDYEEAQWVRFDDLEVEDRVVFVDDIKKSLRDEMPYLLFYQVVPMVEVTCPSTEGTEAGPPSYNESKTSIDLASSGSLYEGDMNGRHGEEDRAAARSKPPSIRLSSEAEPLPRRTVDKAGTASAAASAAGGDSRRHSIVCLDSEAPTPAITPDATSPVIGPCDESSTASRLTRAASRFALTRQSRPASQSGEGRLSFSMTRLGGLRKGSKEPLTEPNNGLGISTAASPTSDAATPTPDSPPPDSPVRSKAGQTKLRGGEVQGEIEERECTLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1B5</accession>
    <name>A0A367L1B5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1B5"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="475" mass="52629" checksum="9640748DDB6BD4BF" modified="2018-11-07" version="1">MTHRLPADYGCVIVSGTARAFEAWGPASDECFLSLSSRQKRTLPVPPAPSTGVPHALRKGLHPTPPLVFKRFMHRQHRTGPAEVADAPKSLTFTCYVANLFEPLRLSCPAPIYISSGEPEMDLALDKDKGRAEPSVKEAQSGEVVFFPFYFALSETEIHPYEPAAGKTPAPSRWVLDFSYPPLNHSTGLHYEETDARHELIATEISVGRRGDTGRYPYMVLSYSFPGLKRVRAIGDHCANCVSLSERDGGGKSVESRLLVLIFAGGRHCIRSTCNVELQLRLSHSRRSSEVEGEERGQPGLEGKTKTRPGGWSTGPVVYALRLESSWRPPGNKSAAAYDRGCQKRSVVENHFIDTFLFALLLTVRLCEQRHLKEFGLPGLIPREGGREGGKTGIFNVSVCLFHFVHLCLTSRWWFDTYPSMLDIPPVATPLAQLSAGKLRGVSVSERIDKFIQRCDKSTSYPLHQMETLVHSASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1U1</accession>
    <name>A0A367L1U1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1U1"/>
    <dbReference type="STRING" id="1330021.A0A367L1U1"/>
    <dbReference type="OrthoDB" id="3870679at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="375"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="567"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="738"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="779"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="832"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="415"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="613"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="744"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="780"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="832"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="845"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="858"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="874"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="894"/>
            <end position="923"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="923" mass="99025" checksum="CFB945813B1871DF" modified="2018-11-07" version="1">MHPMTTAATSPYPGPPPQLRRHKVLPRPRNDQMLDDAPPLSIPAHFDDSPAPNPHVPERGLRRIGPGPDPPPTPPDHSRNSSQGHSAVPLSPSVHDSSLPNMFAARRPVATPPDQPSLPTPDLTPPGPVARSRTLRPSALDRGVSRVTGSDSLTGSFKTAREVPSLSDDESGSFAAASHDAAPRPIDPSQSIQSRHLLDLALNHIDRACGEPPVSCARKPIAAPDANVSSTTQVEHQEYHHSDSSPKRSPRRDRGTRAPPASSSTTPIHAEPRRLPGHSSRPSLSAVVGAILIAGPPQRRRTLRHVRKRGTLREPDKASLALANEAAAKMTDASAFDLPERQVDARLADDDTSSVASGRIRRQVWKEGGIPVVVVPDRRSSSQTRPKGEPASLRSSSSRSSRKTASSEESRGRGRSSTRGQSAGAEAHLCTRDGSPAQAAALCPSLSASTTTPNDKSQNARATEACQPWPGGGTAAVSSPSKPVATTEMDRPSPTSIRFEKEESQDLLDLGRHEDAASAKKYSSRNTPFSIASFETAPEVSEAMAVHMYPHQNSSLLVVDHLAKSPESTLQGTEADQTPDVPKIRTTCPNGGPVTPPGKASSDSDEADSPLRNPRPPPPPPPKQPPPAINLIPATPSGCTPAHEKAAREGNYFEATGDMPTSHPSSLVRRALGRRRKSMESPSPGTLKPLGLLARSLSLSRQARHGQAPRAALAVNPDAVPVSLGEDAIPAEEDKLHPYWRPHPVHDDDDRCRGGNRSGSPRRTLSARMRRTFAILPLGEDERRHSGEVPERRTIRRSPSGSLRVMRRPASVDTMLRVEPWSAPGAGSLRRLWRSRSLRPRGSKGGRGGGGGGGGGSRSSSSRSEGMSKLPRMLSERQRAKRTQELRQMISGPKDVRDGVREVIEPKLPRRRQLRAEEPSGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L205</accession>
    <name>A0A367L205_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Guanine nucleotide-binding protein alpha-3 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_8883</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the G-alpha family. G(q) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L205"/>
    <dbReference type="STRING" id="1330021.A0A367L205"/>
    <dbReference type="OrthoDB" id="5817230at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005834">
        <property type="term" value="C:heterotrimeric G-protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001664">
        <property type="term" value="F:G protein-coupled receptor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031683">
        <property type="term" value="F:G-protein beta/gamma-subunit complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032502">
        <property type="term" value="P:developmental process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010255">
        <property type="term" value="P:glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00066">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.400.10:FF:000007">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000181">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.400.10">
        <property type="entry name" value="GI Alpha 1, domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002975">
        <property type="entry name" value="Fungi_Gprotein_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001019">
        <property type="entry name" value="Gprotein_alpha_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011025">
        <property type="entry name" value="GproteinA_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218">
        <property type="entry name" value="GTP-BINDING PROTEIN ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10218:SF369">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-2 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00503">
        <property type="entry name" value="G-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00318">
        <property type="entry name" value="GPROTEINA"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01241">
        <property type="entry name" value="GPROTEINAFNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00275">
        <property type="entry name" value="G_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47895">
        <property type="entry name" value="Transducin (alpha subunit), insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51882">
        <property type="entry name" value="G_ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0564">Palmitate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0807">Transducer</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="101"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="183"/>
            <end position="188"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="291"/>
            <end position="292"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="316"/>
            <end position="322"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="341"/>
            <end position="345"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="410"/>
            <end position="413"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601019-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI08444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="493" mass="55692" checksum="5E5CF8EAC0DF2A00" modified="2018-11-07" version="1" fragment="single">AAASATATATASSSSSSSSSSSSSSSSSLLPHLLAILSSSLPLRFQHRFDLVRYANGRLIRPKSSQRLPWSTSPILPDDLRLRPVRPRPPPHTSPIRLVAKRRARPRAHPSIIPGLPPKRSHAPSLDGRIPSQRLLAVMGGCMSSSAEEAELKKQSQAIDKVIEEDSKRLRKECKILLLGSGESGKSTIVKQMKIIHLKGYSEEELFNYRSTVYKNLVDCAKAIIQAMEQFNIKLQNPENKTHVDYLMQYQTESGPEAHIDPQVGVAVRSLWSDPAKEDLMAHQAEFYLMDSAEYFFQEAMRIVKADYLPNEMDVLRARTKTTGIYETRFQMGQLSIHMFDVGGQRSERKKWIHCFENVTSIIFCVALSEYDQVLLEESSQNRMMESLLLFDSVVNSRWFMRTSIILFLNKVDIFKQKLIRSPLSNYFPDYSGGNDVNKAAKYLLWRFNQVNRAHLNLYPHLTQATDTSNIRLVFAAVKETILNNALKDSGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L231</accession>
    <name>A0A367L231_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8793</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L231"/>
    <dbReference type="Proteomes" id="UP000253664">
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    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="1" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016619905" description="Secreted protein" evidence="1">
        <location>
            <begin position="27"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="82" mass="9203" checksum="947B6B5FFC7260F5" modified="2018-11-07" version="1">MRNVSSTVNIRLLAYLLSLLLTASTPRPLLPLLTTPLPLPRARRPVEHRLLSPSCNRSRTSASPRIPLRPKLAKLRLIYRAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L275</accession>
    <name>A0A367L275_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8906</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L275"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="144" mass="16291" checksum="8E9634F564FC720A" modified="2018-11-07" version="1" fragment="single">MEKVDEMFGYTPPLFGYVRRSKAETIGLKQRRRKNHHVLSVALFEKGVRGGSEGRKEGRKGGVASSSSSSSRNRFHGYFARLQTYAARNEPGLRARLLTWRWGCRLIAGLLGVVIVCWRNAICYMYGEGHARFLHGVSSYHCPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2B5</accession>
    <name>A0A367L2B5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_4773</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2B5"/>
    <dbReference type="STRING" id="1330021.A0A367L2B5"/>
    <dbReference type="OrthoDB" id="3596146at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI08566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="230" mass="25040" checksum="CADC399128A827B2" modified="2018-11-07" version="1">MTLKEILDSLRLGLATPSRIKPTHISELDVIAARHYRDTQSPTLTLAGRSLPLIYKIVSTLVSAPWRYAVLVVDVDGSFDATRLTLSCGDDDLAHVYVQRPDENDYGDEEDDADSIRELVVSAQRFMLYNASASLSRHWWGTVVVGGGSRSGGLAGLVDIVAGFNGWLRIEREPVVAPCPPGLDLAEALARREERQRLVDAAAWVASSSWGDFVFSESGGVMKRPAVEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2U5</accession>
    <name>A0A367L2U5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase type 12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_4722</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2U5"/>
    <dbReference type="STRING" id="1330021.A0A367L2U5"/>
    <dbReference type="OrthoDB" id="10061782at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050508">
        <property type="entry name" value="Methyltransf_Superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42912">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42912:SF80">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase type 12" evidence="2">
        <location>
            <begin position="102"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI08746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="276" mass="29790" checksum="80AA612E7131A919" modified="2018-11-07" version="1">MTCDDATSNAAGVAIYTPFLLRIYDSLVHGLSNRLVWQCSTTKDLIPLFNSTLGRRHVDIGVGTGYLPSTALAAQQQRDLSSSPSSSFSTKTKTTTTTTTTTCESMTLIDLNPHALQTAQARILNTGTRAEIKTLKADILSPPIPFPPPDAAAGKESKHYDTVSIFYLLHCLPGPPEAKMQTVLRAVVPLLSPDGVLVGATVLGKGRRLNLLARLLLALYNRWGVFGNMADSEEVFRHALVASFRHVDAWCVGAVMLFRARGPRVVVDGGEQACAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3F3</accession>
    <name>A0A367L3F3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5072</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI08954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3F3"/>
    <dbReference type="OrthoDB" id="4966402at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI08954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="77" mass="8803" checksum="0211D0F94CB50AA0" modified="2018-11-07" version="1">MCDWEEFLFTCNHSALRLKSFCHFARNDPYHQCYGVKVLRNSWNQGKLCDDCVAERQRQAAQVQASSSSSNSQPSVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3H0</accession>
    <name>A0A367L3H0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI08975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3H0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="66" mass="7501" checksum="1AA448F36743D007" modified="2018-11-07" version="1">MESWDLKAVRDARYTHTDSHSFNNTPNGSPTFNAPPQMHTLPYIPAQHNHKLVKYTVVHHGDASAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L483</accession>
    <name>A0A367L483_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1422</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L483"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="178" mass="18839" checksum="0DEF22AA191A9319" modified="2018-11-07" version="1">MSIQIAGQDGDIVWLLGPAAYLLSNCHPEIVCHMAPCIHSPLTEEKGLSVTHYVAPTASVYGEHKQGPTTRTSAGETRDRAFRYAEIYSIEKTPNRDTKVAKGRALSDPHVSNAVNLVAAIFGGPPVAQMHIPTDEVDPSPPGLCGVGREFSNGFLAEPGGETVGPEHSPDNALSQDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4M6</accession>
    <name>A0A367L4M6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hypervirulence associated protein TUDOR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_3723</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000015">
        <property type="protein sequence ID" value="RCI09386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4M6"/>
    <dbReference type="STRING" id="1330021.A0A367L4M6"/>
    <dbReference type="OrthoDB" id="2131339at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021487">
        <property type="entry name" value="DUF3140"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021331">
        <property type="entry name" value="Hva1_TUDOR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40630:SF1">
        <property type="entry name" value="DNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40630">
        <property type="entry name" value="POSSIBLE DNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11338">
        <property type="entry name" value="DUF3140"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11160">
        <property type="entry name" value="Hva1_TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hypervirulence associated protein TUDOR" evidence="2">
        <location>
            <begin position="242"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI09386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="304" mass="33645" checksum="CA94E036C9D7D769" modified="2018-11-07" version="1">MKDQATVVREFNELVNMTASELKKWLTSADSQSAGWPKDGEKEDGESVGHDSGRKIIEILESNPEKNPDSYSEDHIDHMRKVVAYCKRHLAKEEKTLSTKSTEEAKETKSYASLKNWGHDPLKREKKDDDSKAEKDESDKQAGDKRKAPESKAESNKKSKTEKDENNDDHKNGDTEDKDTKNGEERDAKSSEEATSKKDSSTTDDDAKQETNGHANGKNSSEDENGQDKDANGKAENGPEPGETVSWNWGNGQPEGKVEEVKPEKTSITTKNGNEASRKGDAEDPAVVIDTGKSKVIKQAHELN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4U9</accession>
    <name>A0A367L4U9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_1409</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4U9"/>
    <dbReference type="OrthoDB" id="4500473at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI09242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="284" mass="30908" checksum="2C48A5558AD03454" modified="2018-11-07" version="1">MASNTWFLPPDFTFLPDGQIALGRIIPDPRRPTATLASVADHPTIKLPEIKSVVEKNHVFAAEKSRTFGLGMLARVLDIANADAKTDLSWYKNKSFSPVDHEVRSYNGPFSPDTLKAIASIDEVKRYMNGGHFGKRCVYIMSAVRVALQSMKITDEQGRKTAVSLGGSGSVPAGAVPIGTGANISGSGQDSKKEGFETAAGIVLSYRLHVIRPKSTVVEAELFTTRAATYVAEARIDDDQEMEAVELNEHILRQEVDAYKEDGIELGDEETYVVVRPTNVPLTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L503</accession>
    <name>A0A367L503_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_1459</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367L503"/>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd19545">
        <property type="entry name" value="FUM14_C_NRPS-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000005">
        <property type="entry name" value="Nonribosomal peptide synthetase 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="753"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="1816"/>
            <end position="1892"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="2881"/>
            <end position="2954"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="5">
        <location>
            <begin position="3550"/>
            <end position="3626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2677"/>
            <end position="2721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="3534"/>
            <end position="3554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="28"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="2679"/>
            <end position="2712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI09302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="4088" mass="450301" checksum="0D9BF1274CBF7C3A" modified="2018-11-07" version="1">MKPVTTMEKNSQTTDTAPCLFPNLSSDCTEEEEEEEEKEESRCLAVPLLFRDIKLLQAAWAVVLRSYTGVDRPTFMYPHGTGSSHHWRYATLDFTEDVEVVTAAERMITRKADDDSARFNTAVVVASEYDASRFALSLEAHHSSDDDWSVVLRYRTSALNQGHASGVVSLLAHVMDQLMSVPLLRLAGLHLCTDDTVEKLTSWNGKEPETINRCIHQLVLDNCRAHPGSAAICAWDGDFSYRDVDRLTAALSQHLASNGVGTGTFVGIYSEASKWTCIMMLAVLRAGGAFVLLDTSLPPYRLSSMCHGVRVRLILCSREKRPPSGLNDVGPVIPVDQHLMTRLPSSSTCRQEPSAVKPEDASFAVFTSGSTGTPKGIIFNHSSFCSGQSAAITTIGYGPGTRSLQFASFSFDLCVQEHLTPLMAGGCVCIPSEAARRWKLDEALSQMKVNLVILTPTVARLLQDKEMGSVKKLVLVGERLVESDVEAWAGRRLQVFNGYGPAECCVFSTLYPFEEAAGLPLGPNIIGSAAACLCWVVDPSDRNKLAPIGAVGELLIQGPIVGRGYVGQDRDRPSPFIPAPAWRSRFPGDRDGVMYCSGDLVQYVGDGLLRYLGRRDSQVKIHGQRLELAEVERRLVDVLPRASQPLVGVVTPADMSSPILAGFVLCHHPETADNDDDVFARPSPEFRRLADQTRAQLADRLSPYMIPPVLLPLKTIPTTRTGKSDRTRLATLASKFSRSELYAFSRDAVQMQLPTSEKEKLLHRAVQQVLQIQDFSMGDTFFGLGGDSVSAMRLARQVRENTGLEISVENMLKPAPLADLASTMCPGLDDDDVPPFSLLSDADSVEGVRRKAASCCRLSSAEDIEDVYPCTALQEGITALSVSSSEAKYVSCSTYRLPRAIDVDRLRQAWDVVIASNPVLRTRIVQSPCGRKTLQAVLRTGVEWDVVRDLDDLKRVREKWRIEMGGPLLRLSVAPSETQGNHLSLFISHALYDGWSLPAVLKQVEEAYYGRTVASRPFKHFVRHLARSADDKDATSFWEKSLKDFSAQPFPGAPTGQVNKGRVRTVRRSFSIPDVRSPDSTLSNCILLSWAMTVSQYTGSEDVCFGTTLSGRNTPVPGGTDSILGPTIATIPLRIRLDRWQTVKQALSSLHSWIQESIPFQHLGTQLIASLGPGAAAACRFQNHVVVQPPASDETTTTLFANGATSEVVDNYVLSLQVTLPASGSDDDLRVEARFDDGVVSPWRMAKIVDQFRHNVLQVLSSPCRAFHDLDSLDAAGRRVIFDWNRRLQVAVNCCVHDLISRICLGQAEKMAVDAFDGSLTYGQLDRQSTKFAARLQGLKVGPGAYVMVMLERSLRAVIAMVAIMKTGAAFVMVDLSTPNSRLEQIRDDTRPVLVITSTQQAARAVDLDTVYAVFTSGSTGRPKGIAVSHRALATAATVSGDAFNLSSSSRALHASSYAFDVSIGEIVYTLVHGGCICIPSATDSRDCLEDVIDRFQVNYASLTPSLTRALDPSKMPTLRTMVFGGEAVTRTDVEMWPERVQLINGYGPAECTIDATFQHNVGLDSPSNIGYGAATVTWIVEADDPTCNRLVPLGAVGELVIEGPVLAKGYLGNTASPSSFVDYPDWLTRLRRGKLGRLYRTGDLVQYSSSGDGSLLYIGRKDNQVKLRGQRLELEEVEQHLLELLPSAKAVVAEVVKPCDAGAAPTLAAFVLLVDDGRREEEEEEEEEEEGDGILAAGDSPMCAAQLAVAEARMMSRLPRFMVPSLFLPLKRMPMSPSGKANRRLLRETASALSRKQLKAYSAGALQQQQQPRVQALSIKEKVLQRCVSHVLALPLAEVGMDGNFFRLGGDSISAMKLAGVVLDAGFSLSVAHVFSHPTLERLATRLEEQADRSSLLPFELLLHQDQHRHMIQAAARECRVDVESIQDIYPCTPMQEGLLSLTMKQPGQYVAELEFHLPQQVDLDRVRAAWSAVYKANSILRTRITSLRSSSGSSLQAVVEEPLGWASDSPYSPPLVVAHGKPLLKVVISEGDEKKLLLWIHHALYDGVSLPMLLEQAEAAYHGASLPARLFNAFPAYVERIDKEESRRFWSEEFEDLDTVMFPPRRLSLLPGQRLSTSYNMSVPDTRGLDFTLASVIQAACAVTLGHFASTRDVVYGLTLAGRSAPVADIGQLVGPTITTIPFRVRLESSMSARRLLATIQEHLVSVMPYEQTGLQAIRCFNSTACDFQCTVVVQPANETVNNNKIFKEPKASNKMLPSSFSSTPLSLEFTISADRRSIQLLADFDDSCLDVADVLSFSRHMEKIVRQIVLDPDAPITDLEEAGPPQDLVVQPSKPVVERLVHELVLEQCRQRPADDAICSREASWTYAEVEDATSRLSQHLISVSTSSVTAICMNRSPWIVIAMLSVLKSGSACLMLDDSHHAKEVLTQTGATLILTSPESRSVAERIAVGSGATVIVVCPALLHSPPPSPPHSPKAIHSSDAAFVVLASSSGGASSLKHVDVAAGLGPEFRLPHRLDDNSRVLHCSSPASRAGLLEILGCLTAGGCLCIPPKAGRVDDFMESCRVNWVMMVPSLTHTLDPLLLPSLRVVVMTGEPVRSADIHRWASRKDVRLLSSYGLTKCPVISAVGQIVAGKQRSFGLIGPLVSGTGWVVTAEDSCKLCAFGAVGELLIESREEGEDGDGDDGDGDDDGDGDGDDDDDDDDDDDEMTTTIPSPPWLARLRGHGRSRLYRTGDLVRYRGDDFQLQYVGRRDRDVRLGGHRLEVEEVESILALHMPADAVVIVELVARSRLFAFVRLSDQGGEALFGQQTDEFLTACSNARQAISQSLPRDLLPTTFIPLNYIPRTISGKINRRLLRDEAAKLPRQNQQPCRTVLMTEAETVTADVWAETLAMPKEDICATDNFFHLGGDSIMAMKLVASARGRGLTITVPDIFAHPRLQDMASAMKRGNNHSSSLQLEPFSLIPEDERESLFQSVEKHCLVSRRQIQDCYPCTPLQEALFSQSMRSSGDYTARFRYKLAPDTDLSRFRLAWNQVVRQNPTLRARLVSTSTTMYQVVLLEEASWEVVEPGNLELFASQLQTEDIHLGCPLLRLILREEEHVEAEFCLVIHHALYDAWSLQLVLNQVQHAYEQKPFTSQPYNRFIRFIAKQDQEAARSHWRSRLSGADEVVAFPSLALPCSGYKPSADAVIQQEVRLRPLPDVTRAITLEFAWAVTVSQYCDSAGAASYGLVLSGRNAGVEGIESMTGPTIATIPVHLKLRKDEPVMQALRRLQAQRATASPFEHYGLQNIRRLSRQAEAACGFQSMLLIQQQLPSTEERSSLLTPVEDKDRAANFSSHVLEITCQVSGDECLVEFDFDSSLLDERQAKRLLAQYVQAIEQIQTRAGDGLRDTFKTGDLAQYTSDGSIRHCGRKKTRAEIRGQGIDLGEIEGRVVDLCRRLHISDVVAEVVNSADGEMLAVFTVRPADTGAEGWLLLPASQEHRQQSSRLLERLKEQLPKHMVPEVIIPLTSLPHSTDVRKLLRAEAEALTREQMEQYRPPTSKKRAPDSEPQKLLQHVFADVLGLDCEDVGVEDSFFRLGGDSIIAIRLVEQARARGFTFRVSDVFQTPRLSDLASRVVESTASPPLEQVPSSRVDRCEEVLKKLAADGLSYAEEDIHEILPVTQAAERYLFQTPEYWIVNLRGSVKLERLERACSALVERHGILRTIFISTGQDDEHLQLVSRQMKTTIKYFQTSKPISRFVDDYRQIDLMEMPTLATPLTDFLYVQSTSDEEAANQALVVRLSHAQFDGYCLPTLWRDLTHLYQGIVPLSDPVPYSLHLQQWSRSRTDDDGFAFWRKTLAGSSIARIDNAALNSNTPPISPEESEFITSSRVVHIGKALAHDMTAATVVKVAWAVLLASLTGTADCVFAQASNGRNNYDKAKDVVGMCLNFVPVRARIKPEETVRELVDFIQRQHRESLAFELIDFREIVKRSTSWEGGTRHQSVVLHQNLDPDESFKFGDDAEAWVTCSYEWPHPPDDILIESLPTKDGDLQMTMDTRSNVLTRENADAVMGVLCRLIALVARGDSQTRVGVLLEAVEEAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5B2</accession>
    <name>A0A367L5B2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">tRNA (uracil-O(2)-)-methyltransferase</fullName>
            <ecNumber evidence="3 11">2.1.1.211</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_3883</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>uridine(44) in tRNA(Ser) + S-adenosyl-L-methionine = 2'-O-methyluridine(44) in tRNA(Ser) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10339"/>
            <dbReference type="Rhea" id="RHEA-COMP:10340"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74478"/>
            <dbReference type="EC" id="2.1.1.211"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TRM44 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.211" evidence="3 11"/>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5B2"/>
    <dbReference type="STRING" id="1330021.A0A367L5B2"/>
    <dbReference type="OrthoDB" id="10047021at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141101">
        <property type="term" value="F:tRNA(Ser) (uridine(44)-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011671">
        <property type="entry name" value="tRNA_uracil_MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210">
        <property type="entry name" value="TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21210:SF0">
        <property type="entry name" value="TRNA (URACIL-O(2)-)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07757">
        <property type="entry name" value="AdoMet_MTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 11" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="429"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI09623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="545" mass="61291" checksum="FA6C607C9614529A" modified="2018-11-07" version="1">MPPVFQPDELPPDSSPGFEDETSCRSWVPLYRHGCTFGRDIFVDKMMNLIRNPNLNSSWLFRADILYDDDDDDDDDDDEKRMPVGQSSAAAEDVVKPLPRSIRNMTTQRTLVRTLIPRNQRRDKALDQTCTFHRGPTSDLVIYAAHADSASDLPFYHPAVRAVAHLHSRDPTSESAGSVSILVLPFGEEDGNDVVHLPPKVRRTAYHLLQLLHKHGQSSAAGYVKRVHHDRIVPQARMQNRYAALKDKYARRLVESWLESTDPLKHVFEDLAIAAFLIDLWSDMYNDDDESSCFPGFVDIGCGNGLLVYILAQEGYRGWGFDARARKSWSLFRPAAHLEQRLLLPSAIARLDRESCPEQHLLLHPPDNNNNNSNVPAFHDGNFPPGTFIISNHADELTAWTPILAAASNCPFIVIPCCSHNLAGDRFRAPPPATPRNRLAHTSSSSSPSSPPPSRSTYASLVDWVSRIAHDCGWFVEKEMLRIPSTRNTCLLSRRRRPSHQGEQHHGDQDLVHLDSVIAHYGGCQGYRANLVRLIHHHTDASHSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5B9</accession>
    <name>A0A367L5B9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable quinone oxidoreductase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">NADPH:quinone reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_4007</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5B9"/>
    <dbReference type="STRING" id="1330021.A0A367L5B9"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003960">
        <property type="term" value="F:quinone reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05286">
        <property type="entry name" value="QOR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000053">
        <property type="entry name" value="Quinone oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047618">
        <property type="entry name" value="QOR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF13">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="5">
        <location>
            <begin position="16"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00070796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI09611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="331" mass="35111" checksum="7171AF0A7C7C388F" modified="2018-11-07" version="1">MTLPSTMTAVQISRHGGTDVLQLRSDLPVPAPTSGQVLVRNLFAGVNYIDTYFRTGLYPVPGLPLTLGREAAGEVVSGGGDTLPVGTRVVYVPTDPATGTYAQYTAVAADRVVVIPDKLATDVAAAVFLQGLTAWTFIREAADVKPDTWTLVHAAAGGVGLLLVQMLRHVGARVIAAAGSEEKRELARRNGAGWVVDSRADDLVTQVMGITGGHGVDVIFDGVGKATFDADLDMIAVKGLLISFGNASGAVEPLSILRLTPKNMKLMRPTLMVYVADRHDLVKYTTELFDLVASNKINVAIHGVYPLKDAAKAHNDIEGRKTTGKLLLDCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5G1</accession>
    <name>A0A367L5G1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5G1"/>
    <dbReference type="STRING" id="1330021.A0A367L5G1"/>
    <dbReference type="OrthoDB" id="5279415at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="473" mass="53773" checksum="DACB193A61DF37AE" modified="2018-11-07" version="1">MTSSGLAVFPWECRDKEDQARITYHHPLRRTNQALAEENMKLKRILRENGISWSPVAQAHMKHRDPNVRKLRSSRCAHELGRPSLPTEVILRILKLAMKSPYPIVDPLCPLTPEHLSDQEKARGNQIAIHFLATCKALYTEGTRYLWESNQFVFTTPQALRNFAELSPKFRSNMTHVNLRIVARYYDDQRRRHKLDRCYHADLKKDQLLKVQLRPTETPLVRGGFRCYTWTQIVDFLAALRAPYDPTFRDKKNPRPRLLPSLTSLRLDLVNFSDTLLPFSGSELHDIASHELGCTLNELQVTGMPFDDAGMKASAELSGMLKDEGLYLDGPPSFLAHARYLQPLAGQKWCARVIRAWKGGAADSDYGDVTDEDVDDHVAHFSGYHPRLGALPPAPAEEGHPPSSRDEESVIWKRVPAFRDGDSRSWVQFSRFSGYEITNSEWDTDEEGICPCCGESHPGSSFLEFLGDDDMAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5I6</accession>
    <name>A0A367L5I6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_3979</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5I6"/>
    <dbReference type="STRING" id="1330021.A0A367L5I6"/>
    <dbReference type="OrthoDB" id="9977870at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="175"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="443"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="454"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI09695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="654" mass="72616" checksum="B602820FDFE28DC8" modified="2018-11-07" version="1">MMDDSGPLPHLSDALYRTTVLRLEPDRSEDQLDLQLLAKAHGLGIRASLPSVSHHRPRAASVALSDSSASTSQDQLFSTASDVSASSSYLTPHSSIIGPPSLDASDSSRQSKSWSFSSYDKFLAQHGTAFQASATPAPVDSSAQSIFSVSTKRGGLSGIKNRMMLRRKATRCFEPKLSCWSCRSTFDSPASLRTLSCGHVHCVDCLRSKIKEASSDESKMPPRCCVPVPSSVIQPILDPASQETFLRAVVQFSTPRESRMVCPSASCGVFIPRRKHVDPKAPMTATCHRCHTRVCTMCKRGAHPIGKDCPEDAEVQATSRDSFGPGRKRCYKCRRLVERPEGPTHLVCTCGAQFCSICGGVWDTTVGCPNICTNEEDFKRRDSDDASSVPDALDAAAEAEKEAAEQRSARHPDIQALQRNQQEEMKRFCRFEIDARDALREQHSRQRAALADRQAAEESSTRERQSKTASQLEDSQISEELELRASLEQSERTIRVRIKHMEAYCEGLGRNPGGTAMPPRVVTEENLRALGLQYNIRDDMERQHQSKINMMRDRQAKRMEDLLQRQYDELMQAAAKQQADTTKLGEKLTSEVETTEQLFAARTARLSARWRLAIEVRCKELQDKNGARYASVPPPTWPTAAGKHTFVECHELAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L636</accession>
    <name>A0A367L636_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Anaphase-promoting complex subunit 4 WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_8409</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI09896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L636"/>
    <dbReference type="STRING" id="1330021.A0A367L636"/>
    <dbReference type="OrthoDB" id="308690at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990811">
        <property type="term" value="C:MWP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990810">
        <property type="term" value="P:microtubule anchoring at mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052778">
        <property type="entry name" value="Centrosome-WD_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16220">
        <property type="entry name" value="WD REPEAT PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16220:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN WRAP73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI09896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="51528" checksum="81AC2D37AA27C39F" modified="2018-11-07" version="1">MHSSPVFASSSHCKPSLDGRYVASVRNSTLSVRSVDSLRLVRVAKLAPPATISSLLWAPSSAKVLVSIGLGIDVFSAADESFHASAHLSTSPAGKPSAVFFGACDTEILVCSALNLSVLDLMTSKIVEIGGLKFCQPSTADKGFCIRPGSAHLAVLTRTGGRDLVSLHHPVTRQVMRSWSPDTVDAQALAWTHDGRWLLLWDSPAHGHRLSVYTADGQHFRTVDASSLSLGQGSALELGIKSCQLSPNSEMCAVGDYSRAVTLLGTRSWRQAMRLIHPPTIVPSDTVQVWQEQIMTTAGDKNAVQAFMRATLTVAPPGPSAGAKQSSTGCSQAAFDASSTLLATRLDDWPSTTWIWHVAAAELRAVLMFHSHVTFSWHPTSRELLLISCQDEARRGTSFVWEPLSEGPRTVSAQAQLPTGAATGRCQVSWVSRQTESPELVVADAENYVLLSLSGSNPWQDDEESVLDDTFFFKHQQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6J9</accession>
    <name>A0A367L6J9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Signal peptidase complex catalytic subunit SEC11</fullName>
            <ecNumber evidence="4 15">3.4.21.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L249_8718</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the signal peptidase complex (SPC) composed of a catalytic subunit SEC11 and three accessory subunits SPC1, SPC2 and SPC3. The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids. SPC associates with the translocon complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase S26B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="4 15"/>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6J9"/>
    <dbReference type="STRING" id="1330021.A0A367L6J9"/>
    <dbReference type="OrthoDB" id="10257561at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009003">
        <property type="term" value="F:signal peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019756">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001733">
        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02228">
        <property type="entry name" value="sigpep_I_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806:SF6">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00728">
        <property type="entry name" value="SIGNALPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00501">
        <property type="entry name" value="SPASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 15" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="131"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCI10053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="172" mass="19210" checksum="76DD2D888FC5FD1D" modified="2018-11-07" version="1">MLPGLNNPRQAAAQLMNFALILSTAFMMWKGLSVATDSPSPIVVVLSGSMEPAFQRGDLLLLWNRNLLKETDVGEVVVYNVKDKDIPIVHRVVRKFGRGEKAKLLTKGDNNIADDTDLYARGQDYLERKDIIGSVVGYVPFVGYVTIMLSEHPWMKTVMLGLMGILVVFQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6P2</accession>
    <name>A0A367L6P2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase RBP11-like dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_8475</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6P2"/>
    <dbReference type="STRING" id="1330021.A0A367L6P2"/>
    <dbReference type="OrthoDB" id="510325at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055029">
        <property type="term" value="C:nuclear DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07029">
        <property type="entry name" value="RNAP_I_III_AC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00261">
        <property type="entry name" value="RNApol_arch_Rpo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033898">
        <property type="entry name" value="RNAP_AC19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022905">
        <property type="entry name" value="Rpo11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I,II,III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946:SF28">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase RBP11-like dimerisation" evidence="6">
        <location>
            <begin position="109"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI10100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="177" mass="19639" checksum="E130670D3787E5D9" modified="2018-11-07" version="1">MPGRTKKAEETPSQDISMQDAPPSAQPEAVQDAEMGGDEAEAESEQDDEPQVQRVKILPGSTETGASFEFLDEGHTLGNALRYIIMKKWVDLLMLGPFASFLLFVLVLMRHSPDVEFCAYAIPHPSEPKMNIRIQTYEGTAVDALKKGLADLKDVCDVVADEFWTKRSAYNDKEAMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6Z7</accession>
    <name>A0A367L6Z7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cation efflux protein cytoplasmic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L249_8678</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI09992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6Z7"/>
    <dbReference type="STRING" id="1330021.A0A367L6Z7"/>
    <dbReference type="OrthoDB" id="64736at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098771">
        <property type="term" value="P:inorganic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1350:FF:000001">
        <property type="entry name" value="Metal tolerance protein 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1510.10:FF:000005">
        <property type="entry name" value="Putative Cation diffusion facilitator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1350">
        <property type="entry name" value="Cation efflux protein, cytoplasmic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.379.10">
        <property type="entry name" value="Chitobiase/beta-hexosaminidase domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.670">
        <property type="entry name" value="N-acetyl-b-d-glucoasminidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036837">
        <property type="entry name" value="Cation_efflux_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029018">
        <property type="entry name" value="Hex-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007781">
        <property type="entry name" value="NAGLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024732">
        <property type="entry name" value="NAGLU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024240">
        <property type="entry name" value="NAGLU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024733">
        <property type="entry name" value="NAGLU_tim-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12872">
        <property type="entry name" value="ALPHA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12872:SF1">
        <property type="entry name" value="ALPHA-N-ACETYLGLUCOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05089">
        <property type="entry name" value="NAGLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12972">
        <property type="entry name" value="NAGLU_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12971">
        <property type="entry name" value="NAGLU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160240">
        <property type="entry name" value="Cation efflux protein cytoplasmic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016885710" description="Cation efflux protein cytoplasmic domain-containing protein" evidence="10">
        <location>
            <begin position="18"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="866"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="955"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="994"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1047"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-N-acetylglucosaminidase N-terminal" evidence="13">
        <location>
            <begin position="22"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-N-acetylglucosaminidase tim-barrel" evidence="12">
        <location>
            <begin position="128"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-N-acetylglucosaminidase C-terminal" evidence="14">
        <location>
            <begin position="477"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-N-acetylglucosaminidase C-terminal" evidence="14">
        <location>
            <begin position="651"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="11">
        <location>
            <begin position="871"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="11">
        <location>
            <begin position="947"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="15">
        <location>
            <begin position="1098"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="629"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="632"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF12972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCI09992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1193" mass="133097" checksum="76873D41AB7A408D" modified="2018-11-07" version="1">MKPSVILLAAATTITAAATTDGIAALADRILGHGRGRSFDFALSSEPELWSRWNQAGNDSYVVCAADDGKIRVEGTSLSALARGLRHYATDTLQLDVFWFVGAGRDLPPGPLPLPKQTLRGSSLVPWRYNLNTVTFSYSFVWHDWNDWEKLLDWSAWRGINVQLAWTGYEDIFLQSFRAMGLRDDEIIPFFSGPAFQSWNRFGNVRGSWGGRGDLPLGWIQGQATLQRRIIARMVELGITPVLPAFPGFVPEGLLRVRPGASVSTPSENWIGLPDSFGRTLFLSPLDDVYAELQRLFVRFQTEAYGNVSNIYTLDQFNEMMAPPSEDALRETSRATDAALTAANPAAVWLMQGWLFFNSPGFWVASRVDAYLGGVPDRNGLVVLDLFAESAPQWEKTGSFAGRPWVWCMLHSFGSNMNLYGRASAVVSGPAVARSSSSAPMLGVGLSPEGYGGNEVIYDLLLDQAWSTTKPSQLPAWFSRWAELRYAGLVPAPLTQAWRLLGADVYDCRDGRIPSAGVGVYQLSPRLSGLANRTGHWPAPTVLHYRPRRLRRVWRLMVAAAAEKPSLWTQPTFRLDMVDVTRQLLSNAFTGRYQALVAAFRRDGTVTMETTIPTSPILLLRPRSYSYSYSDSDSDSDSDSDSDSDSDSSDRSREVAERGADLLRLLDGLDAVLSVEPAYRLSKWMGDARRWAASMDEADDLFAFNARSQITVWLSEAPSLNDYSARAWAGLTRSYYRPRWEIFVEGLVNGSSAGSLDEAALIARIGEFERQWQDRGFDGQEATPLRPPAPAVREVIDTPPPPTLLDPDLLRRARLLSTEAHDRHHQRPVRKFYSRQDRLIDQYLTVEGEERVADVEQARLRPRIRVAVYGSFGVNAALFAIQLYAAVSTRSLSLFATAADAFMDLVSSCVMVITSRLARRPSVYRFPVVSLFMRRKDFRPLTALPSQGRTRIEPVGIIIFCALMATVAVELIIESGRSLGQGHHDAAPLQPVPVCLIGVAILSKTSLMIYCFFYRRFPSVHVFFLDHRNDMVVNVFGLVMSIAGHRLAWYLDPVGAICIALLILVSWSSNAFEQAGLLAGKSAPWPYISKLIYVTLTHSSHILKVDTCRAYHAGQNYYVEVDVVMDAQTPLRVSHDVGQSLQRKLEGLADVERAFVHIDYEHEHNIHEEHKPLYDKVESRSLGEWFRQARVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7W3</accession>
    <name>A0A367L7W3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_4335</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7W3"/>
    <dbReference type="OrthoDB" id="4930637at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017041169" evidence="2">
        <location>
            <begin position="23"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI10505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="301" mass="34433" checksum="A22C9FEA3660E4C9" modified="2018-11-07" version="1">MHSSQILGCMVAAFGMLETVSCVPPYVNTKAMISTKPVISTTPVRTNNPAPPALGSGYKILPRKNATSKSKPSLLPPNNNNKFMKPSVLHEAFPCQYPDGRVRPCHNVRAGVTVREEMPWRKELRKEDKELEEELLKDQKKQHEKKMRQEGKDPRDAEEPLPELLPVEEVLYNCTFRSVNRRERKCWLLFFCTGMIVDRWSELLLHKPSNDEGKRLHLEKDFPTRSRRLVYSPKSVGIREPLAHKWDGGAECSFQLDGKVQLSPEMYNSSSKPHPLAGYEEETCAAHFPCHLSLRDEQVKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8U6</accession>
    <name>A0A367L8U6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Protein-serine/threonine kinase</fullName>
            <ecNumber evidence="11">2.7.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_4311</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the PDK/BCKDK protein kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protease inhibitor I9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.-" evidence="11"/>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8U6"/>
    <dbReference type="STRING" id="1330021.A0A367L8U6"/>
    <dbReference type="OrthoDB" id="3264224at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004740">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010906">
        <property type="term" value="P:regulation of glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.80:FF:000005">
        <property type="entry name" value="Proteinase inhibitor I2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.20">
        <property type="entry name" value="Alpha-ketoacid/pyruvate dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036784">
        <property type="entry name" value="AK/P_DHK_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018955">
        <property type="entry name" value="BCDHK/PDK_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039028">
        <property type="entry name" value="BCKD/PDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947:SF20">
        <property type="entry name" value="[3-METHYL-2-OXOBUTANOATE DEHYDROGENASE [LIPOAMIDE]] KINASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11947">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10436">
        <property type="entry name" value="BCDHK_Adom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69012">
        <property type="entry name" value="alpha-ketoacid dehydrogenase kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="12">
        <location>
            <begin position="277"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI10652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="465" mass="49864" checksum="EC0E9900F99AF9AE" modified="2018-11-07" version="1">MPSYIVTLKDDATPEQVSEAKQHVRDQGGKIEHEYTLFKGFSVSFPKDAITTLEAGPNNIHSVSLTSYGRPPLSEKSLLASANFTLSLLPIRLAHRIRALRNLPYIVVSNPNICRIYNNYLHSLSILLPYWHAAAKGQAISQLQDEIRFTNALAELVATHADTIPILAKGFLECRRYISPAEVTRFLDEHLRARIGTRLVAEQHIALHFSSQPHFAPEASPTPCPEEPSYIGVIDTELRPAQIIQSCAGFVADICELRYGSRPLLRIDGESEAILAFVPTHLGYMVTELLKNAFRATVETRSTEPVVVTIAPERPLLQQMADQAPRQSLGGGGFLRSDDEGEVAGVTIRIRDRGGGIPPEVLPNIWSYSFTTFSEDHDDLPGAIVSGGGGGGGGGGGGCVDGLAAISSAGAGGSSIAGLGYGLPLSRAYAEYFGGGVAVQSLFGWGTDVYLRLNGVGSVEACRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9D9</accession>
    <name>A0A367L9D9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5273</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI11024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9D9"/>
    <dbReference type="STRING" id="1330021.A0A367L9D9"/>
    <dbReference type="OrthoDB" id="4181307at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034443">
        <property type="entry name" value="PB1A10.08"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42051">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED PROTEIN PB1A10.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42051:SF1">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED PROTEIN PB1A10.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="189"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="276"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="329"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="429" mass="47346" checksum="DE3B0EA0CDE29C44" modified="2018-11-07" version="1">MKSTILFSGLPTPCRRGQDAAASSRQKRQRKRRPAVDPVPPSLAALLAVTDIPRPTRQQRRPPTPPADALAGPLELLLSPPDDCSSPPPPPPPPLPLPLLARTTSADSIPSLAGDSSSDTLSSLALDEEDDEQSPAVRRRRRRSSPVRRWLPSDAADAHPLVADPDDADDERPADYDDDLQSPKPLLPQPHQLPTRPLRSVFRSNLTASLRALRLAARSFSSSSSSSSSSDDALFVTRSMLAIDPNVPYTDERRPPLLEEMPSAELRRYLNPPPTTTTTTTTTTTTTTTTTTSRSSSLLLDGQPAGFSRRPMYSASIQMQTYKVYRIPQRQQQQQQQQPTANSQGHQHDDANSNAHRSRPPGMRQREMRENPDFIRIAVMEMAMRKCGKLDGQRPGRARWALPPRKPVTKPYEVGGNGVPLRWTAMTVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LA89</accession>
    <name>A0A367LA89_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_7724</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Clathrin-coated vesicle membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LA89"/>
    <dbReference type="STRING" id="1330021.A0A367LA89"/>
    <dbReference type="OrthoDB" id="10259133at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030665">
        <property type="term" value="C:clathrin-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09250">
        <property type="entry name" value="AP-1_Mu1_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14835">
        <property type="entry name" value="AP1_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000006">
        <property type="entry name" value="AP-1 complex subunit mu-1 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="8">
        <location>
            <begin position="167"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI11162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="448" mass="50776" checksum="D3872555BFF97277" modified="2018-11-07" version="1">MASALFFLDLKGKTLLARNYRGDIPMSAVEKFPILLSEAEEESSAVPPCFSHEGINYLYIRHNNLYLLALTKRNTNAAEMLLFLHKIVEVFTEYFKALEEESIRDNFVIIYELLDEMMDFGYPQTTESKILQEYITQESHKLEVQARPPIAVTNAVSWRSEGIRYRKNEVFLDVVESLNLLVSSNGNVLRSEILGAIKMKCYLSGMPELRLGLNDKVMFETTGRTTRGKAIEMEDVKFHQCVRLSRFENDRTISFIPPDGEFELMSYRLNTQVKPLIWVECVVESHSGSRIEYMLKAKAQFKRRSTANNVEIVVPVPDDADTPRFRTNIGSVHYAPEQSAIVWKIKQFGGQKEFLMRAELGLPSVRGDDEHGGGMTGGFGGSMGGVPGMGKGAKRPIQVKFEIPYFTTSGIQVRYLKITEPKLQYPSLPWVRYITQSGDIAVRLPDAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAX8</accession>
    <name>A0A367LAX8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7358</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAX8"/>
    <dbReference type="STRING" id="1330021.A0A367LAX8"/>
    <dbReference type="OrthoDB" id="5243398at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050588">
        <property type="entry name" value="WNK_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13902">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE WNK WITH NO LYSINE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="637"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="476"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="593"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="643"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="674"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="798"/>
            <end position="820"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1077" mass="118474" checksum="8F27374397F54EEB" modified="2018-11-07" version="1">MLMRQRPRRLHISQDLPEIDAGDSFMPFARPRACSHTSGSQRLLVATFRRQPSLFSISNSLTDEENLIIIRRRAFHCEEAAKTSPRPSVSLDHHVLLLVLSSAPRRSPWPQLHVGSIASPTTSIKPDDQPLNNGGAPPAPSPTPVPTPPATSGSAVRDALDSTSFHTDGRVRNPVPTKLQGMTNSRNGNFAVMHIDLTGSKPTDRNAAAKRTSEETEAQARRANQAGWQPVRRSKLVWHGDDADLQTARTSDPTSTPPSRIAVPAAAPTAATAATAAAAPSSTSTSEWLQSRNPTPQEIKAEQARLLTLLRTLHPILVVEQLCKALAYFGGIPGAPPPTDGSFPQSVITNSPGSLLVNWLGEIFPPVDDPAAMADSLHLPPLSSVAGETTGWDRQEASPVPVRRARGRPKGSKSSKVRRDKGMKKSRPAPSVTVPEAQPQPLLGGQDLGHGFSAANHPDPSAIAQVPLLTGDAPKSQINPDASMTSTPGQRKRGRPKGSKNRPKENATKKHSEPGTRGLGTAQSQNFGSPLPRASSMFQGASALAEEGPNDSVTGLAGGAVRTDSSLPVAAADASALPENGPTPPLYATPFYSQGPHQGQGSPQTKHRWMGQQAKAIQSPKVLAQYIKTTLQKDVAYRKTRGSNKTASPQLPTTRGFDPQKAAHIRPPSVTMNSGQGLQQQHKLGHSQPQPHQPQHQHQQHQQHQQHQQHQQHQQHQQHQQHQQHQQHQQHQQHQQHQQHQQHQQHQQHQQHQQHQQHQQHQQHQQHQQHQQHQQHQQHQQHQQHQQQHHQQQQHHQQQQHHQHHQNQHQHQHQHQHQHQHQQQQQQQQPPVAAQRFYAHQAQHQSPILGAADQPRHQGPLQLSGPPRPRSQTGGGYGAQRPAHMSPQMMYTPQQSPMSNQVGSLAHHNTNLGRSMSGPHHYPQNMGRSNSGGSGAPGISHQRGMAAMRGHQHRGKAHGFHGQHQQATSQPNAMGTFHGYGEQSYLNMDYAMRGHQHRGKAHGFHGQHQQATSQPNAMGTFHGYGEQSYLNMDYGLTERDVQDAAAVTALGSPSQLEAALSQAKMRDQHMFQSIGRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBD6</accession>
    <name>A0A367LBD6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Carbohydrate-binding module family 19 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7612</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBD6"/>
    <dbReference type="STRING" id="1330021.A0A367LBD6"/>
    <dbReference type="OrthoDB" id="2362516at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="139"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="426" mass="45507" checksum="1937AE0BFF52A2B9" modified="2018-11-07" version="1" fragment="single">MARLRRLLRSYSLVEKGSEGERTDVFGSNGSSNASQTTAAMLQIVPVDYHRHHTYSTTPTAVTAFELAGSRSSVAALSSLEQTSLPSTSIAVLTTALTMVMPTFRPSETESSFSLVSFISRAPSSLRIPSYPVPEMMMTTPPSTASSSSSPSSSSSSSSSSSFSSSSSSSSPPTSEPKPTPTLTPSSQPQQPYAQNIVLATQLNSIYSILTPSQPCHPNQEACVDGKIARCSNGSFKLEACRQKEEKCWAWPLSSTVGVYVTCRTSLDALKVLGKEALPKKAVRPVVTLTTVVTAFDSYQTSRETSSSPKPGFISVTGPIAGPTPTITTPYLLSTYAPPPREEATYPANPAPKQPPALMVLPVDGYSAKQKDAAPPHKDEAYYSTVTVTETKVPDTVTVTVTLSIKTQITGRLRFPASKNRLRKYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBF1</accession>
    <name>A0A367LBF1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBF1"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="68" mass="7140" checksum="28410623D6023A3A" modified="2018-11-07" version="1">MHESSIRALIPGNKASSSPKSLLSGIGAGRNSQSFLAWELAPAKRSTLKWSDAIALEKASTTGMGVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LC38</accession>
    <name>A0A367LC38_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tyrosine-protein phosphatase non-receptor type 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000008">
        <property type="protein sequence ID" value="RCI11971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LC38"/>
    <dbReference type="OrthoDB" id="3921198at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="578" mass="64067" checksum="01F3CCC18811862D" modified="2018-11-07" version="1">MDPVHSLANATASAPAPAPARDETRTPMDVSTAMPPHSLLSSLSPALSPASMPRPDKTPARLPLFSPASTIGHIPTSPPPRKDTISSISTQATTATLASTETSNTSYSADTSPSLQQSTLSVADGPDVSNSRRTSRRRTGPLTQQSRERAALIRKLGACADCRRRRVACHPSHHNLTWEDLVNKFHRPHSPGIQDIAPSLAAGRPPSPASQSTTTFLQEPQEMDVDLTVPTHHQPARQPLNEARIRTPLPSGPRLEKSLSLPGIESLKNELQSNVPRTLSTSNRGRYNAVQVLLLFWQDDDDVPVIQAAVKELADVIDKYYHYTFQIQTIPSSSDACRSSWRWLSRQLNEFAEEHDQRDVLKIVFYAGHTHLDGNREMVLASSRDGSKASVIRWNGIQQILEEACSDTLILMDAAYYPSSRMVRRKGVLELIAASVSEEHIAALDRCAFTRALAEELRTRATRSNPLSAVELHSILFASYPKFIRDRNPERETVTSCPAPLHAMMSGNSRLPSIYLSPVYQNRPLRNSFSCENSPQLHLSIKLQDDNVDVESWNEWLRLMPEGVKDIKVDGPFRASFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LC82</accession>
    <name>A0A367LC82_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_7556</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LC82"/>
    <dbReference type="STRING" id="1330021.A0A367LC82"/>
    <dbReference type="OrthoDB" id="10264707at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052742">
        <property type="entry name" value="Mito_N-acetyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015416">
        <property type="entry name" value="Znf_H2C2_histone_UAS-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43138">
        <property type="entry name" value="ACETYLTRANSFERASE, GNAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43138:SF2">
        <property type="entry name" value="PROTEIN SPT10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09337">
        <property type="entry name" value="zf-H2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="23"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI11842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="413" mass="46462" checksum="9B67BC6EDF402B37" modified="2018-11-07" version="1">MEDPGGSTIFHVSGQPSFPPSPSGQSGLPPDLGPRHVTLRDRQTAATIVPLWSRQQVPDSLLAYLCDQLNREIEGGDTYPMTESHVCTGSFIVTDGSRNRGVGRLMGEAYLEWAPRLGYRYSVFNLVYETNVASCRIWDSLGFKRIGRVKSCGSLRSYPDRLIDGVIYGRDLPVDGAGGGTDDVGEERFDKIRFYLKYGRYPNGAGRAEKSRLRSAATHYKLLEGDRLMLRDKEVVAEPARQYEVARRVHALHHGGINKTTASIAERYHWSRIKETVSDVIRACAECKDPPTKQSTSQRNHHHHHNLHSIPSSSSAAASPPVLDRLQQLDGLHAHNHHLHHNLYHQPIDPQIVNDPHRHNNPADEEDPFAHYPPHPDFQTLLEDDDDDDDNDDDKDAVNRDLDMLIEHDPVQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCD2</accession>
    <name>A0A367LCD2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_0730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCD2"/>
    <dbReference type="STRING" id="1330021.A0A367LCD2"/>
    <dbReference type="OrthoDB" id="415411at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047429">
        <property type="term" value="F:nucleoside triphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017111">
        <property type="term" value="F:ribonucleoside triphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009141">
        <property type="term" value="P:nucleoside triphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16018">
        <property type="entry name" value="Enpp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.180:FF:000003">
        <property type="entry name" value="Type I phosphodiesterase/nucleotide pyrophosphatase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151:SF120">
        <property type="entry name" value="BIS(5'-ADENOSYL)-TRIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10151">
        <property type="entry name" value="ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="647"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="685"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI12075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="788" mass="88024" checksum="B8EB554091FFFD50" modified="2018-11-07" version="1">MARHRPVPSAAADGSLLSPVAYDDDASSLHSRSDQESDSEDDQLQQRARNSRELRAHDRIVLMEEEEMDRLVTSSRRQQRRGSGLNVPNPLRMFGRSASTSSLARRGSGLNVPNPLRMFGRSASTSSLAVPDSSTEDQHDLVSEKWQARRARRKQRRNKMLSDARHGEDGELMYEMEEGDMDRSSSTGESTPRSHSAEADRHRLGLVANAKAVRGRGCRRFCHLHLLIVTGFAILALFAWKLSKGHARPGNTHPLVSNGTALFAPTTIILSLDGFRADFLHRGITPRLNAFIKEGVSPAYMRPSFPSVTFPNHYTLATGLYPESHGVVGNTFWDPDLRAEFYYTDPTRSLDPKWWSGEPFWVTAELQGIRTAVHMWPGSQAHILHVEPSFLDEFDGNMKLPDKVARILEFIDMPGEEDESVRVKSMRPQLIAAYVPNVDLDGHTFGPNSTEIRSTIKEVDQMLDQLFQGLEQRNLTHIVNVIVVSDHGMATTDTSRLIQLEDLVDTSLIEHTDGWPLYGLRPKNEGDLQTLATVVKEKAKSNPNVDVYLRDEDMPERYHFSNNQRIAPLWIVPKPGWAIVKKDEFNVEQGKKEGLVYHPRGLHGYDHEHPLMRAIFVARGPAFPHANGRLEPFQNIEVYNILADSVGMTPRPNNGTLRLPLRPIGKHDEDDTESEPADPPPTSVAHETSQMSPQRPTLAQGSPKTDESTVPSRPTLPAKVQGSAGAEADETHNNTAQDVTEEGDEPTSESIQDRIKAALSYMWDKVRGGVRKGNELWEKVRGGAWTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCD6</accession>
    <name>A0A367LCD6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF1690 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_0846</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCD6"/>
    <dbReference type="STRING" id="1330021.A0A367LCD6"/>
    <dbReference type="OrthoDB" id="5544375at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012471">
        <property type="entry name" value="DUF1690"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07956">
        <property type="entry name" value="DUF1690"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="39"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI12071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="150" mass="17341" checksum="CE814878163C6434" modified="2018-11-07" version="1">MGAGNSKHEDRGDHLWKRHANTDASRAKQTERHIQSRVAEELKRLTKREDETLRNARAKIAAHADADADADSEGPDRVAVSKEIEDLRRKLDQRKQMRTLPESVDKARSDVVRCLRDNDRRPLDCWKEVEAFKAEVKKMEDNWVEKVVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCE7</accession>
    <name>A0A367LCE7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">Alpha-glucosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">L249_0558</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Glucosidase involved in the degradation of cellulosic biomass. Has both alpha- and beta-glucosidase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>Hydrolysis of terminal, non-reducing (1-&gt;4)-linked alpha-D-glucose residues with release of alpha-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.20"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCE7"/>
    <dbReference type="STRING" id="1330021.A0A367LCE7"/>
    <dbReference type="OrthoDB" id="5839090at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004558">
        <property type="term" value="F:alpha-1,4-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06602">
        <property type="entry name" value="GH31_MGAM_SI_GAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF67">
        <property type="entry name" value="ALPHA_BETA-GLUCOSIDASE AGDC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016703157" description="Alpha-glucosidase" evidence="16">
        <location>
            <begin position="24"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="18">
        <location>
            <begin position="91"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="17">
        <location>
            <begin position="259"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="19">
        <location>
            <begin position="706"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="486"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RCI12099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="22">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="917" mass="103140" checksum="8A0DB92520310E6D" modified="2018-11-07" version="1">MRFWSPLFLIATAAATSLDACHGYEAYDLSQTDSGLTASLRPLGVPCNVYGIDLDDLTLEVTHETDDRLHVKIQDRANQAYQVPESVFPRPEGRSSARQSKLKFDYTASPFSFQVLRAGSNDVLFDTSAASLVFESQYLRLRTSLPKDPYLYGLGEHSDPFRLRTSNYIRTLWNADSYGVNGDTNLYGSHPFYLEHRQNGSHGVFLLNSNGMDVMVNSTDDGKQYLEYNTLGGVLDFWFFSGPSPISVVQQYGQVAGFPALQPYWGLGFHQCRYGYRDAYDVAEVVHNYSLARIPLETMWTDIDYMDRRRTFTLDPERFPLNTMRQLVSHLHKHDQHYVVMVDPAVAYQDYPPLQQGVKDDVFLRRDNGSLWLGVVWPGVTVFPDWFAANTQKYWNGQFDSFFNASEGVDIDALWIDMNEPSNSMCPWPCDDPYESAKGMPPPAPPPRHPPRPLPGWPCEFQPPGTCKSERSGTTEEAMVPLTVLTPDTEGAPVPRSAGTRGDAKGLPGRNLLYPRYAIHNKMAPHDSWNSDKGGLSNRTIHTDVHHQNGLVMYDTHNLFGSMMSWASRVAMLARRPTKRPMIITRSTFAGAGSKVGHWLGDNMSTWDMYRNSIRSMLAFTALFQFSMVGADVCGFGGDATEELCARWASLGAFASFYRNHNVEGALAQEFYRWESVAESARKAIAIRYRLLDYIYTAMRASSEDGQPAIQPVFYLYPHDRRTWPLELQYFYGPALLVVPVTEKGATSVRFYLPDDIFYDWYSHKPIRGEAAEHTFVEQDTTTIPLLIRGGSILPARLHSTQTTTELRRQDFELLVALDAQGEAWGELYLDDGESLDPRDDISVISFRYSHADRTLSVQGTFNCPGVAPRVVNVTVLGAGSAPEQGVREHSLEGPRLHSSSYGVDFGLDQPRTVHVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCM9</accession>
    <name>A0A367LCM9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCM9"/>
    <dbReference type="OrthoDB" id="4927414at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016927235" evidence="1">
        <location>
            <begin position="46"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="213" mass="21826" checksum="92C8149D36F10D5B" modified="2018-11-07" version="1" fragment="single">PLTNKHQRFPSIHPILFHKHPPPPNISIMKLFATLLLAGAALVAAQEEYYGGGNDGGNAVGGADGGDYQCKAPHEQCSAADTCCEGYSCNGADTGYGFCLADNNGGDSYNGGGNDGGAGYEAPSCLGESTACYARGGGSGNCCAGLSCVAPPGDRAGQGICVSPSAYTTASPDSGSASYGGHKGPKRYPKVLSKAWSKAWSKAWNKAWTKVWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCT3</accession>
    <name>A0A367LCT3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_1358</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCT3"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI12221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="104" mass="11819" checksum="71AC8CE09FE0DEA3" modified="2018-11-07" version="1" fragment="single">MTLVRQDGSTLDGDTLWYVHTPVHNCTFTFIFIIRSERCHLLPTNPLPSFYTKMAREKSYVTGLPSIANQLVIGRGSLTRRDPIDALSLCSASPVLWRRTNRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCV9</accession>
    <name>A0A367LCV9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0255</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCV9"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="309" mass="35026" checksum="D26A3BFA214279A5" modified="2018-11-07" version="1">MSSCFPPSVESPTAERLKMRLLKRGKKRSTAGDPGKNPKRVLESMSDSPVSLSPIDLEMRLLKRKGERDRWHEKLVLPPPCCVVFGGRGVARQRLRNLKRKGREAFAVERWLKSESWLPRQLDPKPPTAKTCAAGDRGDKTGKLLKREQQERSSPVAEAHSRLSGRLLKRRPGFVKSSFEMQSRTAVADKALVNENEKAKAWIRVEKKKNPQEILVPASVVHRLIELVPFSKVNCIVVPDRKSELSVLHLPVSPFRLRKAWTKKPLAICCKKCGVVVKRGRSGHESASYDRLLVPHLQTEKRVVPKKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCZ2</accession>
    <name>A0A367LCZ2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Interferon-related developmental regulator N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_0926</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IFRD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCZ2"/>
    <dbReference type="STRING" id="1330021.A0A367LCZ2"/>
    <dbReference type="OrthoDB" id="18978at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039777">
        <property type="entry name" value="IFRD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007701">
        <property type="entry name" value="Interferon-rel_develop_reg_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12354">
        <property type="entry name" value="INTERFERON-RELATED DEVELOPMENTAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12354:SF1">
        <property type="entry name" value="INTERFERON-RELATED DEVELOPMENTAL REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05004">
        <property type="entry name" value="IFRD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Interferon-related developmental regulator N-terminal" evidence="3">
        <location>
            <begin position="88"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="58"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI12290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="461" mass="50864" checksum="D3DF6841CFA7D623" modified="2018-11-07" version="1">MNHARVKALKGNGKTVSKRAQKSGRASGTLTPQGSSSPIASLLASPSHSNTPSRVASDDSDNEEDGDLDFDDMNSSVHSTGSGPDVADDAATGFDAQALIDGLSDRKRNNSNVREQYLSAYIRMLRNRYNDWVKAVAATLTEIFLKEANRGTTSRERLLSLQAYSLTLATVDDLDVYEAGSKLLKQMLTDEDDQDCRVHSIYALCMTTMYGGGLEEAALELMQFFVDIIQSDGESIEAHDDAVVVSAAMRGWAFVASHVDDYADYADSAMDAFVDQLDSGDVEVQSLAGHCIALIYESSRNHETETGEPFQLPYDPQRLARRLGELVKLSAKSVSRKNRRDLRENLVSVVTSLERGVGPYYSTALYIPEPDTFVPPSLRTDDGRAEYGCRCKLRVGGRTALIDTWSLYSRVEMMKLLFRGGLENHVFVNPVVMDCLEDAEWDEGLAEPERKPKLSAKARKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LE99</accession>
    <name>A0A367LE99_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_0527</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LE99"/>
    <dbReference type="STRING" id="1330021.A0A367LE99"/>
    <dbReference type="OrthoDB" id="161814at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF73">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN CTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-0187">Copper transport</keyword>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI12754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="207" mass="23241" checksum="FFED99548933C582" modified="2018-11-07" version="1">MDQLFTLVKRHSGMDHGSMNHSSMGHHDHSSMGHDHGGGSGCKFSMVFHSTTIDSCFLSDKWRITSTGMFAGSCIGVFLLAVTLELIRRLVKEYDRFLARKHLASHDNDHNHRPVNDHHPSKEATSVITRVAAEFRPTIYQQAVRAFLQLLLITCAWTLMLLVMYFNVYLTLSILLGFYVGSFVFQWDNIPIGSGLSRGSDAVFCCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEL8</accession>
    <name>A0A367LEL8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_1089</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEL8"/>
    <dbReference type="STRING" id="1330021.A0A367LEL8"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="33"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI12869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="495" mass="52601" checksum="F37E0133C3E968B7" modified="2018-11-07" version="1">MAEAVLVGAGGRKITVPTGLFIDNGFHEASLGRTVDLENPANGAFLATVAAAQAEDVDRAVASSAAAFTSTWRTNGPSQSRALLNRLAELIERDAEDLASLEALDAGMLYRESLGLSVQQSAETCRYYAGWVGKLDGRSMSIEQGMAYTRRQPFGVCAAIVPWNAPLMITLWKLAPAVAAGNTLVIKTPEAAPLYGQRLAQLVKEAGFPPGVINILCGLGPVAGQALADHPQVRKISFTGSGAVGRRILESSARTNLKRVTVELGGKGPSIVFADAAWDNALLHTTMGITAHNGQICAAGSRIYVQDEIYDRFVAEFSARTKESVIGDPLIDSTTKGPLVNGAQKSRVEGYIQKALEEGHHLLHGGEKSSQEAGHFVPNTAFVDVPPTATIMREEIFGPVASIARFKTEEEAIALANDSSLGLSAAVFTNDISKAMRVSDAIECGQVTVNMWGAVNVNTPFGGFKESGMGRDLGKEAIEEWTEVKSVKLNILHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEN0</accession>
    <name>A0A367LEN0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_0915</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEN0"/>
    <dbReference type="STRING" id="1330021.A0A367LEN0"/>
    <dbReference type="OrthoDB" id="2956246at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="393"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="236"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI12884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="449" mass="47782" checksum="5CD98B65DAB24527" modified="2018-11-07" version="1">MGRDACVSRLVVNADESADAPSHENRIATGLDRGLRSWSPRSLGHASTDGRPREAPSPPTTTISCTCQPTSSQTEKDKIKERIITTAPKMEAACLPNPRPLIPSWTATPIANLSLSAGGLLALADLNTVANRTVVAGGSSWLDALVLAPGLHYQQAADALDTTASSSAAVVAVEVEHGLERRRHLVSNAALVSFLRRLWLDAAAAGHRPLTLDVSRARHDEKGLRRRLTCRPRPSSPSSSSSSSSSSSVAGLPVDADRLSHVLYLLSPLLTSAASSFMILLGDWWGLSFILALMISRTLNIWTIKQRSRPLLVPPATKPLSPSDSDMPDRPTEYAVDLGDGRSALLLGLSSDLQALTTQSRLRPKTDLEGYLEAAAKLLVYMVAALSGNLSQAGAMVLMALLLISAGLLGLSNTRASGLRINGCVAVLRLHSAPGPSLDEDRRRVENLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LER7</accession>
    <name>A0A367LER7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Dynein light intermediate chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_0764</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LER7"/>
    <dbReference type="STRING" id="1330021.A0A367LER7"/>
    <dbReference type="OrthoDB" id="27603at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035974">
        <property type="term" value="C:meiotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008467">
        <property type="entry name" value="Dynein1_light_intermed_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022780">
        <property type="entry name" value="Dynein_light_int_chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12688">
        <property type="entry name" value="DYNEIN LIGHT INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12688:SF0">
        <property type="entry name" value="DYNEIN LIGHT INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05783">
        <property type="entry name" value="DLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="336"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="512"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI12911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="560" mass="61593" checksum="545DF1E619FA6B83" modified="2018-11-07" version="1">MAGGDQRGSTYTSRSTDSNGPPPRNLWTSMLESVASGKRLPDKNILVLGGTPESQRDFIDSLYEAPSKRSFDRQANPPVANSFALGYTYYDVLDADQDDTLARVSIYLLSQPSAEFAPLVSPLLTPEAIPNTALVVLLDWAQPHLWLRQLWSWIQVLEQVMRQTSTEARKDMENVMASWKERGRGGAAVNLDGTTNAIGTAGDGDGLLPVGPGEWTDPLGLPLCVVCQNAQRMEFLERNKGWREPDFDTVLQYLRTVLLRHGASLIYTSQNTPSQLPVLLHSTLGITSLLKRQPLKHNVIDRDQIVVAPNWDSWGKIRILGGTFDAELVSRGWEEDINLPAGSSPPSMEEEEEERDEDDDDDDDDDKENGVEDVHHASPARNPSAIAQYESWCRDPNSGGLAVVESAMDDGSAVATESEDPQAFLERQLKILEAFKAKAPLPDKQADSNNNLTASRRLDLAGDEKSVHDHIGPVQCNMGGIQVDADDMLQRLKANYCPLSFCLPTMKDRNARVASSSPPDEGDMASPIEGLAKEYDTEQLQNFFTGLMNRTTGSGDSPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEX8</accession>
    <name>A0A367LEX8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-N-acetylglucosamine diphosphorylase</fullName>
            <ecNumber evidence="3">2.7.7.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_0263</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate + UTP + H(+) = UDP-N-acetyl-alpha-D-glucosamine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEX8"/>
    <dbReference type="STRING" id="1330021.A0A367LEX8"/>
    <dbReference type="OrthoDB" id="532420at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04193">
        <property type="entry name" value="UDPGlcNAc_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000075">
        <property type="entry name" value="Probable UDP-N-acetylglucosamine pyrophosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039741">
        <property type="entry name" value="UDP-sugar_pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952:SF2">
        <property type="entry name" value="LD24639P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952">
        <property type="entry name" value="UDP- GLUCOSE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI12984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="503" mass="54907" checksum="5C9F1F2DA575A14F" modified="2018-11-07" version="1">MDKAKQLLHLGSKPSSHSPPSAEAVSELKEKYARAGQDHVFAFWDSLSDNERADLFDQLEGFDPGRIDSIAKRALGKGQEEAKNKGGDASLEPLPESATASVLDSGAEKIGSWYRAGLKLVAENKVAVVLMAGGQGTRLGSSDPKGCFDIGLPSHKSLFQIQAERIRKIQELAAGSESSSKVIVPWYVMTSGPTRKPTQDFFEKHDYFGLDRANVQIFEQGVLPCLSPEGKILLESKARVAVAPDGNGGIYQALVLSGVLEDMRRRGVEHVHAYCVDNCLVRVADPVFIGFAASKDVDIATKVVRKRNATESVGLILCKNGKPDVVEYSEIDKATAEATDARQSDLLKFRAANIVNHYYSFRFLESIPQWAHKLPHHVARKKIPSADAKTGETVKPENPNGIKLEQFVFDVFPFLSLDKFACMEVRRDDEFSPLKNARGKGEDDPDTSKRDIMAQGRRWVQEAGATVVADGGVEVSPLISYGGEGLEKLKGTTVTAPAVLERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFG6</accession>
    <name>A0A367LFG6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_1157</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFG6"/>
    <dbReference type="STRING" id="1330021.A0A367LFG6"/>
    <dbReference type="OrthoDB" id="9999863at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140107">
        <property type="term" value="F:high-affinity potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051143">
        <property type="entry name" value="TrkH_K-transport"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064:SF5">
        <property type="entry name" value="POTASSIUM ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064">
        <property type="entry name" value="POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI13161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="392" mass="43245" checksum="D78A46EE0E2CAC5A" modified="2018-11-07" version="1">MPQKADKGRAGQSFYSKKRLFHLNPNPNTVYFFGIHLFGAVFLACWIRLADAKYRAYLDSLGVNSTWWAFYSSQSAVDNLGFTLTPDSMGHFRDASLPLLLLGALGLAGQTLRPVFLRLSLWLCAKVPGRAERAESASYLLENPQACLSMFPAVATRAQLIIISALTFGETVFITVNDGHGVEVAGLSLGQRLSAAFFQAAAARHAGMTPYNLANVSAAAQLSLLVMMFIATCPIVTAEYDNSAILASTTSPTYLARLVREQLGLDVWWFFLAVFCLTISEARSVQDDPVEGRAKQTNKKKKGLSDFPLMFEVVTAYNNVGISLGHPDVDAALCAKFSVVGKLVLCVLMVRGRHRRMLHRFRLLPDRYLLRLEEEEKEEEEEEEEAIGGSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFS3</accession>
    <name>A0A367LFS3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L249_0117</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPII-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFS3"/>
    <dbReference type="STRING" id="1330021.A0A367LFS3"/>
    <dbReference type="OrthoDB" id="49016at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF4">
        <property type="entry name" value="SECRETORY 24CD, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="12">
        <location>
            <begin position="271"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="13">
        <location>
            <begin position="349"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="15">
        <location>
            <begin position="602"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="14">
        <location>
            <begin position="708"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="11">
        <location>
            <begin position="838"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="26"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCI13276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="998" mass="109038" checksum="EF108DF93F41FD30" modified="2018-11-07" version="1">MSDYSQYHALGQGMGNDPNDPNRQRAPYQPQGAPYAAATAAGPPPYGNQPTVQSQSFPGGQLDDASLAAQMGSMNIGTAADGQGNTRKKKRDRHAYHMVEPTGSSQAFNGMPPPDVASSHGVGQFGDAQQANPNQFPVPVGASFGPGGFMAGSGSTNDAAATVAAAGQSKMSQDDLPSVPLARDAAQQHYLRNVYPTFERHVPPPSTVFFVAFDQGNASPKFARLTLNNIPATTEDLQATGLPLGLLLQPLAPLQPGEAEIPVLDFGDAGPPRCRRCRAYVNPFMMFRSGGNKFVCNLCTHPNETPTEYFCATTPQGARVDRDQRPELHRGTVEFVVPKEYWTRDPVGLRWLFIIDATQESYNKGFMETFCDGILNALYGGEDQEAEQGGEPKRKIAEGVKVGFMTYDKDIHFYNMNPRLEQAQMMIMPDLEDPFVPLSEGLFVDPYESKALITSLLARLPGMFSVVKNPEPALLAALNSALAALEKTGGKMVCACSALPTWGPGRLFLRDDGNHPGGEMDKKLFSTEHPAWKKVAEKMAASGIGTDFFLAAPSGGYLDVATIGHVAATTGGETFYYPNFIAPRDSPKLSAEIAHSVTRETGFQALMKVRCSNGLQVAAYHGNFIQHTFGADLEIGAIDADKALAVSFSYDGKLDAKLDAHFQSALLYTTASGQRRVRCSNIIASVSETAKEPGVREQSIRSCMKFVDQDAVVALLAKEASTKLATTSSNLKDVRNWLGERAIDIMACYRKHSAQQHPPGQLVMPERLKEFCMYVLCLVKCRAFKGGIEGSDRRVHELRMVRSMGSTELSLYLYPRIMPIHNLQPEEGFADGETGQLKMPPATRATFSRVEPGGVYLVDNGQQCLLWFHEQTSPNLVADLFGEGKDSLQSLDAYTSSLPVLETHLNCQVRNIIEFLKTMRGSKGMTLQLARRGIDGAEYEFARMLMEDRNNEAQSYVDWLVHVHKGVQLELSGQRKREAEHEAAQSLANFTGLRPAYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGI1</accession>
    <name>A0A367LGI1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 23">Pyruvate kinase</fullName>
            <ecNumber evidence="7 23">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">L249_5547</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27 28">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22 23">
            <text>pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4 23">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5 23">Belongs to the pyruvate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="7 23"/>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LGI1"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00288">
        <property type="entry name" value="Pyruvate_Kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000055">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000066">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002145">
        <property type="entry name" value="ABC transporter (MsbA subfamily)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.33.10:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.60:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="entry name" value="Pyruvate kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004491">
        <property type="entry name" value="PRK05826.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004978">
        <property type="entry name" value="PRK06354.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF399">
        <property type="entry name" value="ABC TRANSPORTER ATNG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="PK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="19 23" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="20" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14 23" id="KW-0418">Kinase</keyword>
    <keyword evidence="16 23" id="KW-0460">Magnesium</keyword>
    <keyword evidence="18 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 23" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17 24" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="478"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="514"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="871"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="915"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="951"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="1010"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="1101"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="26">
        <location>
            <begin position="267"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="25">
        <location>
            <begin position="599"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="26">
        <location>
            <begin position="875"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="25">
        <location>
            <begin position="1196"/>
            <end position="1443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="RCI13536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="2015" mass="220866" checksum="D62867D238D79368" modified="2018-11-07" version="1">MNATADALVGPQLPGRFDFTLVFEQAAFSIGPSAILLLASPFRILALVRRKPTFGADSLLWFKLSCIFLLFGLRLAILALWLNFSPVVGTRLTLAAASLSLADVVAMGSLLYAEHRFSYSPSILISLYISVTVLLDVANVRSLFLRRVLFPVAIISTVALALKFLLLALEEVPKKHFSVLFISKETSSGLWNRSALWWLNSTFYKGFTAFLRVDDLPSLDHKLGSRRLASRLNREWRSIDKPGRNSLAYATFKAFQAPFWTAVIPRLCYTGFAFAQPFLIKSIVNFLGTTRPGDPSTVIGGLVTAVALVYLGIAISKCHYMHHTFRLITSVRGGLIALIFAKVVELEAAEDSAAVTLMSTDIDGITGGLQDIHDIWASFIELGLGMFLLERQVGAACLFVLFPAVVSSIATARVARGIGPAKALWNSKVQKRVSTTSSALSQIKGIKMMGLGDRISQLIQSLRVSELDSSKNFRIFSVWMNMIANLADQLTPILVISVAVFWTKGGQNLSVAEAFTSMSIVALVSSPIVNLISAYPTFVASLACFGRIQEFLLLTERDDYRSKISPYCDSLSARGGIGNPEAREAPSRLSDEAEARLAISVENASFSLMDKHDAVLKNVSITIRKSTLTMVVGPVGSGKSALLKAILGEGRLLSGSVRLEPGPVAYCDQVAWLRLGSLRENILGPGRYDEFWYRRVLWACALEEDVAQLEDGDLSLVGSGGLALSGGQKQRVTLARAVYARASIMLLDDVFSSLDRKTALDVFGRLLGADGILRREGTTVLLATHTVAQHLTFADNIVTLDESGTVINQLRADDSNRLNEHRGPSCLELERDKGCFLEFRDEKPAARKDAAQDFPEQVTLRKTGDMSLYRFYLKSVGTLLFSGWLVFAAGFIFSGKAPQIWLRIWTESGTTKHTAAYFGGYLGFGLLSALLSGVCVFYFMIILVPKSAQHLHWLLLSAVVKAPLWIFTTTDLSSILNRFSQDMTLVDQVLPLAAFTTTFDVFNVIAETSLIASGATYVGAVIPLCILAIYVLQKYYLRTSRQMRLLDLEAKTPLYRQFTETSAGIVTVRAFGWKEDVLAEHLQQLDHSQKPYYMMFCIQRWLNVVLDVFVAALAIVLVGFALGFSSAATQGSIGLALLNVVEFSQSLSKLINSWTGLETSLGAIARLKDFLAQTKTEDSEVDKATPPDAWPARGSIDMMGVTAKYNIEDIQSQPAIRDVNLKIDGGQKVVIMGRTGSGKSSLILTLLRMLDLESGRVVIDGVDTSQVSRQALRLRLTVIPQDTVELPGTVRQNLGLYGGSEECGEDGEDEAMRHALSRVGLWETVSRRGGLDGDLGDVGLSTGQKQLFCLARALVSKAKGSVKGGIVLLDEPTSSVDDKTDIGMQRIVDEEFAGFTIVTVSHRPEAAREADMMVHISGGRVAEVTRMNHVEGGGRILLILSFLLVQDRFRLVSPRRCPLVLEVRTFFFRFPSSVKMAQNPNRSRSFSVMAAAQQDHLNGGGRINWLASLDTAYKPERNYRRSSIICTIGPVTNSPDKINSLRDAGLNVVRMNFSHGTHEYHQSVIDAARKAVEEHPGRPVAIALDTKGPEIRTGNTENDVDLPISAGTIMNVTTDEKYAKACDTANMYVDYKNITKVIEPGRIIYVDDGVLAFEVLSIKDDKTIQVKARNNGFISSRKGVNLPNTDVDLPALSEKDKADLQFGVKNKVDMIFASFIRRAQDIRDIRKVLGEEGKDIQIIAKIENRQGLNNFKEILEETDGVMVARGDLGIEIPAAEVFAAQKKLIAMCNLAGKPVICATQMLESMIKNPRPTRAEISDVGNAITDGADCVMLSGETAKGAYPTEAVREMHEACLKAENTIPYVSHFEEMCTLVRRPVSTVESCAMAAVRASLDLGAGGIIVLSTSGESARLLSKYRPVCPIFMVTRNATTSRFGHLYRGVYPFLFPEAKPDFEKVNWQEDVDRRIKWAVDQALKLKTLTIGDMVVVVQGWKGGMGNTNTLRIVRADPEHLGIGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGQ1</accession>
    <name>A0A367LGQ1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5645</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGQ1"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="23799" checksum="50701DCD0E514D42" modified="2018-11-07" version="1">MLDITSAFDHVSYNKLSELLYFIRARTADTSSLTLNGSIVVPTQEARMLGVWIYRKLNTGEDETAEYLFLRCPRTRPILFVYLAVRSPLASWLYSLCNCVAYHRRLYLPPDAPLPRLPRPLRLRPRPRLGGRPGPRLGVPITTRVAAGSPPPSLSSPPPPAAATPSSTDTLSSSTATSSLCLLAGTSTTSLSPSPLQLRGAAPVPPSTFGGVRAASGICTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGS4</accession>
    <name>A0A367LGS4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_5483</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGS4"/>
    <dbReference type="STRING" id="1330021.A0A367LGS4"/>
    <dbReference type="OrthoDB" id="2157498at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029164">
        <property type="entry name" value="PIG-Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39400:SF1">
        <property type="entry name" value="PIG-P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39400">
        <property type="entry name" value="YALI0E29227P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15159">
        <property type="entry name" value="PIG-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI13597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="328" mass="35680" checksum="6DC8C400D7ACA980" modified="2018-11-07" version="1">MDAKKNSAIQPDESAGGSAASHRRGASGGSSLLARLPFMRPLSESKLRADDDDGPVPAVSISVQHHHRTRRRRGSLRKVALLGRGAQRDKRDDRYSAIDTTAPAAEADSESSNAGVSAVMEHDALGLKIPRLPSSSGPDDSVVSQLTSMSSSATHQAERDSERCNLYTSTTDEEDLLHMPSVSSPPRASLSMLSGSDSYFATQAIADRRASFQQAKSPLSYSGISTNTLPPPASDWNYSETEWWGWVVVTVTWFVFVMGMGSCLDVWSWAWDVGKTPYAPPELEDDPTLPIVGYYPALIIMTGVMAWVWVVVAWVGMKYFRHAKISGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LI59</accession>
    <name>A0A367LI59_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI14114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LI59"/>
    <dbReference type="STRING" id="1330021.A0A367LI59"/>
    <dbReference type="OrthoDB" id="4925351at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="25462" checksum="B67B3C8C8A821DFB" modified="2018-11-07" version="1">MRPVPLSADPDASRPDALPSHTSVAPISCFITTEANIEALDSAAAVPDFDHPPKHHTQGSPSGYSSAFSDRSAHHELGSTSGDAAGYSTKPNPGDPNVSMAQSSLHQLVMPSLTVPRRRSFTDVGKSLGNLRILVSGQAGIGKTSLIRSFGQNCQHIVYLDPITSSPTRRITEIFGSTKFCPWWRAKSEPVARANKRRKFMTDEHLDKNICFADCPPTTSDAEAGHSHNSRILDFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-05-03" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJ15</accession>
    <name>A0A367LJ15_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_6165</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJ15"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="81" mass="8804" checksum="E673AA803A72EF7B" modified="2018-11-07" version="1">MSPPYTAASTSRTQTSSLTRISIPATETLTGLNTVCVLLRRPSAERAPRVRAGRPIADLLRVMRKKVIWLGFAALGIVVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJ80</accession>
    <name>A0A367LJ80_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJ80"/>
    <dbReference type="OrthoDB" id="5401902at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="573"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="680"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="773"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="874"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="956"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="784"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="905"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="973"/>
            <end position="983"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1009" mass="108246" checksum="C79EB7884BFF84FC" modified="2018-11-07" version="1">MVITRSKRAKRILRCLSAAQHEDHVLSYSTTPLIRYNLLHDYHRCVQVSVELGGPADRLSVPFSFDALPNFLQSQLEAQKIADGSRLLLRLAPLLTFVQAHLPRLDRSRAFPTLFIWHSRENHRSYLFFAFVEIRMVSKTYTARELLRLRKVSAGKEFYDRLVEKLRKEQGLGDIHRIPPRVSLPLIEEEDVDAPAKPDPGPTKNIAARQLDGTDAEWKYRGRIESEEDVAHPICGPAGPSAQKDEGFQRFYKSVVSPTHVRVTAGGRIVPNTRGSSSPTAKWSKDRSSGDSARNGGREQSEPIPIPQPHFGAFSTMIPGFAPAVAPGMSVAHAPFHMMPWHLGVNMGGAFSMLHPSVAALSGHMPGSVSSAASTKSDKHSESGNSENTGAVHVSPPEHFDHSRPFFYNGQWMMPSGHAMMPVGMPSMAGFPVPMMQPRYGMHPVMHLHTMRSDPSLSSRVAPSPAAAAFAGAAHPPVSSIRHNPSLSSRVAPSPAAAAFAGAAHPPVSSIRHSEITKRQLENLRSHLRFIEDQLLYNKHQIDERVMEQQTQVLRHQIHLFEKNLEAQLTIEGGQSTQPDSNEESTGSDSSNDVIRPKPSTAKCRNEAEDVSTSQDDTPPARVGRGIDRLAPQHSPSAAPVRSLPLKSALKKTRSAEINKKSSSLPVSAALAPPFQPRVDGTRGSASTGSPVCVSGPLAASDSSGGDTEARGDAGNSRLCTVFQRGCGPSAAGGADYMLGRDLTDDELLARDMYWCDAPRSLPIGQAKFGGRALHPASPVRGGSSASEAASSSPVRPPSDYSRATAKAESDLFKAVEQAGQRPYRSNATQSEELPRLESPVTPTPASAKQTPRKAAFAAGRSYDDFRKALAGSVRAAGEHSENKSSSDSGDDSNLLFKGRKSVAPNKSKTPNDIWQSVLRKGKSSGAAIPGTVSSMTAQGVLPNYAGHATASLTPAIANTPVSPQRVSSRKPAGSGDAGSAASVDEEKKVENRPPTGNCAKGSVRHAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJG4</accession>
    <name>A0A367LJG4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJG4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="74" mass="8320" checksum="90D204F75B8E42D1" modified="2018-11-07" version="1">MLREKQSSKDNKRHTNSQAKISLVSTRIRSSLKATPQRPAKGLVIAKQDACHFSLELRRRTAMTLPSALPPLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJG6</accession>
    <name>A0A367LJG6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_5989</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJG6"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI14412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="163" mass="18647" checksum="91F9CA89B9A26C7C" modified="2018-11-07" version="1" fragment="single">GAIAVIAPESTRYSDRHSDRRAHPIDLGTRQPSQRSARCTYSGHSARSVVTAVITRSTRCTNSGHSARPRWSYQSQIVRLIHDVEVFLQTTYLPSQISKEGKYILTNGKFIISFNFITSSIQSPLLPSILLQSSQNHHHVIRLLLLYYVIYTLITHHYFHCRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJM8</accession>
    <name>A0A367LJM8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_5946</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJM8"/>
    <dbReference type="OrthoDB" id="1640476at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.225.20">
        <property type="entry name" value="Ub domain-containing protein, DC-UbP/UBTD2, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032752">
        <property type="entry name" value="DC-UbP/UBTD2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038169">
        <property type="entry name" value="DC-UbP/UBTD2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022617">
        <property type="entry name" value="Rad60/SUMO-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039869">
        <property type="entry name" value="UBTD1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13609">
        <property type="entry name" value="UBIQUITIN DOMAIN CONTAINING 1 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11976">
        <property type="entry name" value="Rad60-SLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16455">
        <property type="entry name" value="UBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="191"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI14472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="268" mass="29759" checksum="2552F869C0A1E4D7" modified="2018-11-07" version="1">MYLPATFSPPRPSRPNSPYPAGGHNASSARHINQAPSSAAARHRALHQQINKPLRRHQWTDDDRRWTRRSLDLERADFFDTRVTGRPHIWQTIHAALQVLAQPHESDDDYHDALATAQSILSAADISLPTGDLANGVYDSLGNYYQLPDWVVADPTNLTAADRDSHLSSSDADDAQRTRADKGKAVVHLHEHILLRARLSETGRDIEIAVDKADLVRAVAAGIASEADLPSNKKIRLSYMGKMLKENSSLESQGWQTGHMVNAFVFPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJN4</accession>
    <name>A0A367LJN4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJN4"/>
    <dbReference type="OrthoDB" id="2910287at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016992939" evidence="1">
        <location>
            <begin position="19"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="128" mass="13526" checksum="D589BE0E2FD795B0" modified="2018-11-07" version="1">MKVSSALTVVSAAALASGSPVEKRAIGGVLLCTGPNSTGICDYKVYELNKCHQLSAPFHHNTSTFAPDGEAFSCFPRVTDCSAICMSPTGCTFGAVSFHSPLKEDLGKIQWNTLISSFDCSLNRTESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJR0</accession>
    <name>A0A367LJR0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">acylphosphatase</fullName>
            <ecNumber evidence="1">3.6.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_6786</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an acyl phosphate + H2O = a carboxylate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acylphosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.7" evidence="1"/>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJR0"/>
    <dbReference type="STRING" id="1330021.A0A367LJR0"/>
    <dbReference type="OrthoDB" id="7961613at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020456">
        <property type="entry name" value="Acylphosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47268">
        <property type="entry name" value="ACYLPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47268:SF4">
        <property type="entry name" value="ACYLPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="Acylphosphatase/BLUF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="12"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI14668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="84" mass="9473" checksum="3B875A98647CB871" modified="2018-11-07" version="1">MPPSRGIGVGFRFFTRQKAQDYGITGWCRNTSDNKVEGEAQGEDDALEKFLRQVDQGPREAKVVQLTKEDREVVTGESSFAIRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJS9</accession>
    <name>A0A367LJS9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJS9"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="95" mass="10255" checksum="A0CAFCEA11AD5437" modified="2018-11-07" version="1" fragment="single">MGIISISFSHLLNTNTSPASNSSSIASFRPSRDSSSSSLSRDHLPDSSTLHPLLAVKRLNTELVLPNNLPALAKYSFSILLPKTPLLNRQIDLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJY0</accession>
    <name>A0A367LJY0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_6457</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJY0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="69" mass="7902" checksum="444B5ADDB4E9E948" modified="2018-11-07" version="1">MTLGVGIQRTRLFKSAWDHGLDFTSPQAKPSFRRAGCCSSHRNNLFVPRSLHRYRDGGKYTVMFEVIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKB5</accession>
    <name>A0A367LKB5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nickel/cobalt efflux system</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_6573</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NiCoT transporter (TC 2.A.52) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKB5"/>
    <dbReference type="STRING" id="1330021.A0A367LKB5"/>
    <dbReference type="OrthoDB" id="5197598at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015099">
        <property type="term" value="F:nickel cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004688">
        <property type="entry name" value="Ni/Co_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011541">
        <property type="entry name" value="Ni/Co_transpt_high_affinity"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31611">
        <property type="entry name" value="HIGH-AFFINITY NICKEL TRANSPORT PROTEIN NIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31611:SF0">
        <property type="entry name" value="HIGH-AFFINITY NICKEL TRANSPORT PROTEIN NIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03824">
        <property type="entry name" value="NicO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0533">Nickel</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="341"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="368"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI14883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="382" mass="40672" checksum="A0F7141F4BBB1525" modified="2018-11-07" version="1">MERVRQAIDGTGLSGRSLAIIALVAAVNGLVWAAAGIVLRFHPALAPTALLCYTLGLRHGLDADHISAIDLVTRRLVADGLRPATVGTFFSLGHATVVMVTCIAVAATSGAVRDRFDGFARVGGIIGTAVSAAVLLLLCLGNGWVLWRLVVRLRSALAARRRRRHGFDGDEDEVTLAPPGFGPISRFAGYLFKAIDRPWKMFPLGLVFGLGFDTSSEVALLGIASVHAAEGTSIWLILIFPVLFTGLYTSKAFSRDDVAILYYSIVLTAMTIVVSAFIGVIQALSLAQNVAHAQGPFWDGVTAVTDHFDAVGGGICALFVVVGLASVVAYRPWRRRIDRRAADESFPETDGQPSPSREAASPGLGGGRDLEEQHMLARDEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKT6</accession>
    <name>A0A367LKT6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_6860</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKT6"/>
    <dbReference type="STRING" id="1330021.A0A367LKT6"/>
    <dbReference type="OrthoDB" id="3474066at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052973">
        <property type="entry name" value="Fungal_sec-metab_reg_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392:SF3">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="660"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="393"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="97"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI15029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="797" mass="88591" checksum="9442165924A87AD0" modified="2018-11-07" version="1">MLPCTPAPSLGIGTLPLFPASKIAMQELPRPVNHKRPGPYLTTEILEPSRQHLDLAATQLSPPYDFTFPEKDPGPFGLSSGLQTCDESQLVPIPVKRRKLDSQTSMPQGLGSPGHQEEKLGKPDSSNQHSDSQASVLSYWSDAGSSSSHAMALPFAKHITNLSPFWCVCAGFKQSDGYCPLSQASPAVYDPNDPQPYGSEKQQYMHMPSQSEPQDLSLIGSEQFNPGTSEPETQSMSMAGYLDQGRMQLASPPDRAKDSLFSQGRLPLEHFTDEYMPQDIASSHMPYPQCYGPNVGQERMNAVADFSEAFGRPTIALRGSVGGCSVAAPFDMLSSAGGSLGESGPLNGWSDACDGHTSSSFDVLLPDQRGGKRGPFKDPKLREQTAQTRRTGSCIRCRMQRIRCESDPEDPGGICLTCTHLATTKAGRFPCLRYKITDMKLYKPGQVPGYEWTRRWDHSITETIQNWASPDVKFIAVSAGYSTKCIELQVRRFIPQDGDKLVRTWDHNGTKKSVEIPPYALVDFELTKSTYTAHIEDIMTDTIQHVLKSSGDLLERTYFEAVRLMRHPETPEDSAKLLRRTLTLWVSIRLSTTSGFLVGRETLGMSGSILDETSPNAGMIPMPPVLGAQLDLVLIHHIQTKLRRDMLETLQKMVLKNKQATWLVIYLVTFILLHNASLITAHDAGYARKHGMKSFAAAPLRTRRQSARIPSGSKYPARTFPLLQQGRVSVLGRMQGKDLRSLADLGEDELMFVHATKDYHKMNRVEWQQIRNGGVYEDDFFFVSQLFEENWKPQSTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKV5</accession>
    <name>A0A367LKV5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">U6 snRNA-associated Sm-like protein LSm6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L249_6804</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway. Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 di-snRNP, spliceosomal U4/U6.U5 tri-snRNP, and free U6 snRNP). It binds directly to the 3'-terminal U-tract of U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP complexes. LSM2-LSM8 probably also is involved degradation of nuclear pre-mRNA by targeting them for decapping, and in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKV5"/>
    <dbReference type="STRING" id="1330021.A0A367LKV5"/>
    <dbReference type="OrthoDB" id="268799at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01726">
        <property type="entry name" value="LSm6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000037">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021:SF1">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 15" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11 15" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="12 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13 15" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="10 15" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="9 15" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Sm" evidence="16">
        <location>
            <begin position="14"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR006609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCI15065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="91" mass="9703" checksum="DCD9291B9E6D8851" modified="2018-11-07" version="1">MENGGGATQNEGNDPSSFLSDIIGNPVIVKLNSGVVYKGELQSVDGYMNIALEKTAEYVDGTKRREYGDAFVRGNNGGPANEPRTCELSMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKZ3</accession>
    <name>A0A367LKZ3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_6597</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKZ3"/>
    <dbReference type="OrthoDB" id="4925188at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI15104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="158" mass="17868" checksum="F3FC9B1724B47F2E" modified="2018-11-07" version="1">MKTQVILALVATSFGAPHTGEASMSLVKREEMAASCLKMLCCKNKKRHLENVEGEAEAQCLVCWKFGICSTPVREGSKDQIGKVSAEIDQNIVHNQDNFQDGGFWIRRGGREYWVGNNGKYWEWMGGDHDKSRGQFRLGGDGEIKRAQNGKWYYTFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LL07</accession>
    <name>A0A367LL07_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7021</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LL07"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="85" mass="9536" checksum="972F59EF20132331" modified="2018-11-07" version="1">MLTVCVISLSRAYLGGIVESRDLDGVRDPAPRLRIMRCNKIGSGMFPFDTLEVLPLRFESEITYSLALRSVSLDVPYGLKPLFRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LL21</accession>
    <name>A0A367LL21_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LL21"/>
    <dbReference type="STRING" id="1330021.A0A367LL21"/>
    <dbReference type="OrthoDB" id="5343576at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="458" mass="50686" checksum="CB7B7B3067A609B6" modified="2018-11-07" version="1">MPRLRAMDYQQLTYALADAFNSLADEVQLLADRKTVLEHKLRFAHEQFQYLADKYAPSTPEIAETLAKLQLPPHTSVDDTSPVPLPQRSSPQSQHQLALVIRDGRRAASRLVSLAGSSKATVSSRQSLSHTSPRDTTMSTTMEQDFTVEGRKGNLQCPFTAGSRASVPRQTAENPHCAVMVEDDSTTRSPPAASKCPIRLMDKHSAAEIAHYVETHKHELPRSHEVCLRRYQKNEEQIRKLDHKYGNIVSMIEGLGHLHQPMLPEAEEAAAQHSDVDRASNERVETWAQAVSTTSHPEGADRQPVEEGERQARFDRPLKEVRVGESPSRPWGISVPFYEASGPGEHQPSSPPPAPVQMPNAAQSGDKCPVYHAKPVKTEEAKRRTQFGRTPRTPAGGTCSPPLLFQSALRDSPPNKAGTSAGPQMMFTGPVFIGYPMEQALQFLNQYQRPPRHDDGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLV3</accession>
    <name>A0A367LLV3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Diphthamide biosynthesis protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_6988</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DPH4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLV3"/>
    <dbReference type="STRING" id="1330021.A0A367LLV3"/>
    <dbReference type="OrthoDB" id="18529at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.660.10">
        <property type="entry name" value="DPH Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007872">
        <property type="entry name" value="DPH_MB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036671">
        <property type="entry name" value="DPH_MB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037507">
        <property type="entry name" value="Ribosomal_mL59"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040922">
        <property type="entry name" value="Ribosomal_mL59_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28041">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28041:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18126">
        <property type="entry name" value="Mitoc_mL59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05207">
        <property type="entry name" value="Zn_ribbon_CSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144217">
        <property type="entry name" value="CSL zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51074">
        <property type="entry name" value="DPH_MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="152"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="DPH-type MB" evidence="8">
        <location>
            <begin position="276"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="36"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="189"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="37"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI15389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="357" mass="39259" checksum="211696986296E2B3" modified="2018-11-07" version="1">MAIATPSASHLISLAKTLPPPLQRFLARWPPASIAGRDAKPTPWQEERPHPFRCAKDPITGKRKDPVYSQRRQAELVKMARQHGLEELLPKTTKGTEFQLARRVRLGLRVKGTGVGQKVKGHIFERTMIPKEEKSHVGNAQTHQEFQTASITHYEVLGLSSSLLDAVAQENPSRLVRQAYRRALLRNHPDKAGAVSSSSSSSSPSSSASPSSPSPAVQALHRPSQQPKQPPLYTVDQIGQAFAVLASPSRRADYDASLLRLVADASLSGPTRFQTGVENADLDDLPFDEEGGRWYRPCRCGNDKGYSFDEADLADAADEGLLIVGCLDCSLWLRVHFAAVDDEDETHRRPHLTASKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLW7</accession>
    <name>A0A367LLW7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transposase Tc1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7036</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLW7"/>
    <dbReference type="OrthoDB" id="5151590at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI15418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="138" mass="16004" checksum="83DCC7DBE18DBE4F" modified="2018-11-07" version="1">MLAPPFRPSARPSFEVSPYHCHRIRCICTAFVGPFFFKEALYVNNASNYAQKTLGIEHYKALRRPKLDEDTAARRLEWARRYVEKPATFWSNWIFLDETSIMRREDKKTKCFGPLSPSLDGPYLHLCSATLMLEGVGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMM7</accession>
    <name>A0A367LMM7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMM7"/>
    <dbReference type="STRING" id="1330021.A0A367LMM7"/>
    <dbReference type="OrthoDB" id="5428259at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="594"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="604" mass="66664" checksum="CD7B6BFB60CE1CD8" modified="2018-11-07" version="1">MASLAATRGNTPSSATKQIPLLCIVCPEAPRFSDVSHLLTHIASKGHLHHEKQTKLNSHQDLTASALLNQYGQWYKDNGIEALLVERLRAKQMKEAAKTRRTRGAAPLASLNSRRKTKRPPNSAVKSELEDFSQDLHLFPGFLASENEVDVQDGFSVANDMLSLKGQVWPGMGKMDLANDDMKRTRNQRKPNSVIEKMRRTSEGIEPTQVVMTPDFEVERIKGVYDSSSPIPGQGEETPKKPSRPKRKRHEVLAEVSSNVPRGGVRRSSRNTLTKANRGQRLKLDYERDTSSDQTPSLGSFKQGHDLFQDDDGSSPGMPRHPALDTGKELMEAGVFEDRSFSTPLHQDQKYGSSSPLTSPSVSSWYTRYDPRDRFVLHPLNPMSRSNVPSPTPSTRDMSARLLPARDVNRGRHQTHGYLSHGGNMTLGSLAQVEASFGIGDSPMYNSSARLPFATTNNFGALTQENFRLNPAQQQQPKHADYSSATGDSLSTSVGSQYLTMPESNPLFSHDRLFFPLSQPHVNQSLSSLGFTPINRGRDHSLAAQDHERPASGPSIKTESHSQLCDGIDSSDAKQGPFIGGLWDPQPTENNLDLAEELGEDVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMP0</accession>
    <name>A0A367LMP0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MGS207 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMP0"/>
    <dbReference type="STRING" id="1330021.A0A367LMP0"/>
    <dbReference type="OrthoDB" id="10265971at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025337">
        <property type="entry name" value="Questin_oxidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870:SF6">
        <property type="entry name" value="MGS207 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14027">
        <property type="entry name" value="Questin_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="400" mass="46090" checksum="2F8034D362C6A0A1" modified="2018-11-07" version="1">MSGILGRLVGSQLKARNLAPIDVHQVETNPDRRARRLKHLLKANHINYSIVFDDSLFVNHNPHLLGAAYLLGATVDQLHALYEAEIRHLEPWSPSPAEIVDLDWQDFLGDKRYQRAYVDFFEDKLAMTFAYDWKQEVEHFLFKAGEAPLFHALIGGLGHPLVHLGYAYEMDCKEIAMEALGLACLQHDFLQKYLDDVSYTRPSPFSSTSPMELLIRMSEDRRFSQLPRSLHLDEIEAVFDKHQDLVMDYWNAWEIEDPVTQLRLSQEAAVSLLARPNVHAYNFYFVHLLTTSHAARVLLPLIPRQHHVTLLREWWLLAVMIFIMKGRPRPTSGTVDDDIGTKGWAYVEKEALTSRWSKDAHYIKAIRAMRDAAKTWTDADDGWYLKAAVAFVDGFEGWTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNB9</accession>
    <name>A0A367LNB9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_1958</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNB9"/>
    <dbReference type="STRING" id="1330021.A0A367LNB9"/>
    <dbReference type="OrthoDB" id="10266426at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015218">
        <property type="term" value="F:pyrimidine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990519">
        <property type="term" value="P:pyrimidine nucleotide import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000075">
        <property type="entry name" value="Nicotinamide adenine dinucleotide transporter 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049562">
        <property type="entry name" value="SLC25A33/36-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829:SF1">
        <property type="entry name" value="CARRIER PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G06780)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="57"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="162"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="287"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI15943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="411" mass="45400" checksum="53B6466F0F468885" modified="2018-11-07" version="1">MSHDESSQARRVFPSPTDDDDDDDASAPYPRRAAGGSDPRVPKRNPTMLQRWAVRASESQFNALAGALGGFTSGIVTCPLDVIKTKLQAQGTYRLVDDGRHVGHPKMYNGLVGTAKVIWRQEGVRGMYRGLGPIILGYLPTWAVWFTIYNKSKGWMARHSENKHMVSFCSSIIAGASSTIVTNPIWVIKTRLMSQSHMPETDHHLDTLYPKASNTPRQSLYSWHYRSTMDAAKKMYMSEGLASFYSGLTPALLGLTHVAVQFPTYEFLKTSFTGQGMGAAPAQGESAHWLGILSASILSKILASSATYPHEVIRTRLQTQRRPLVGEHYLQGLGVSTPASGAGREGPKYRGIVMTFRTILREEGWRAFYAGLGTNMMRAVPAATVTMLTYEYVMRQLNSAKVEGRRLMGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNH2</accession>
    <name>A0A367LNH2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphotransferase</fullName>
            <ecNumber evidence="6">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_2736</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the hexokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="6"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNH2"/>
    <dbReference type="STRING" id="1330021.A0A367LNH2"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24000">
        <property type="entry name" value="ASKHA_NBD_HK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.367.20:FF:000011">
        <property type="entry name" value="Phosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF24">
        <property type="entry name" value="PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="276"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase N-terminal" evidence="8">
        <location>
            <begin position="66"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="9">
        <location>
            <begin position="276"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI15959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="554" mass="60138" checksum="91753706B5F05B15" modified="2018-11-07" version="1">MTTLRTAFIAAVIKSLLRGKSFIQAILASSISSLAIGRPVLARKPSRRNLHDFLKEAEAAILDPVSRHGLLDLAAGLREQFLDRLQTDPQSMLPSYSHQLPTGGEAGQYVALDVGGSTLRVALVELRGRDAREGGTSDIVSMRNFRIGKAVKDLEGMAFFDWMAGRICDTLTSGLSREHGPDKPLPLALAWISPLAAAPKHTTADFLCRQTSLGGGRLQRMGKGFMADSGLLGEDLGNVVKRACHRYGLDVELRAILNDSSACLLSRAYSYTSTRFGLILGTGLNMAAFLPVAGIGMSKFGPRPDGWFDEATHVIVNTELGMFGNGILPMTRWDRTLNREHPRPDYQPLEFLVSGMYLGEIVRLAVLEAVGTTGILGGVVPPSLLAPYSLGTDTLALIESDETSELSEAIDVFSQRHPSSHAPTTADLLAIKALASFVSERSSALVATCVFTLWDCRLEAERNYIATLPEDSPERRRAEADMALEVTTVAFNGSVIENYPGYLDTCQRYVDYLVASKCQEVERRSIHLVPAKESSLMGAAVALACVERHDETVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNP8</accession>
    <name>A0A367LNP8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ams2/SPT21 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_2078</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNP8"/>
    <dbReference type="STRING" id="1330021.A0A367LNP8"/>
    <dbReference type="OrthoDB" id="3199820at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000183">
        <property type="term" value="P:rDNA heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030466">
        <property type="term" value="P:silent mating-type cassette heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057725">
        <property type="entry name" value="Ams2-SPT21_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042403">
        <property type="entry name" value="Spt21/Ams2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39147">
        <property type="entry name" value="PROTEIN SPT21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39147:SF1">
        <property type="entry name" value="PROTEIN SPT21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25823">
        <property type="entry name" value="Ams2-SPT21_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ams2/SPT21 N-terminal" evidence="2">
        <location>
            <begin position="21"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="706"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="910"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="963"/>
            <end position="1175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="420"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="638"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="994"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1052"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1099"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1119"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1139"/>
            <end position="1160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI16058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1265" mass="134963" checksum="B2E787E8E1888B54" modified="2018-11-07" version="1">MATPRPVDGKGKNMPVQSAGPQYRHMGLKVHYTFDKDARIHCLARHPQVLNLQVINIDEKITIGIVDLRACLDAIIGCSPELTTGHCDYTIYTVDYSEPDTPLVGQGLLSWALDSMQPGAAHTPPKLVIGRVAPSLLVFNAGSPETLEVRVRFFESLQIQRHASVDCQQCRPVDGPTEKTQAGFPSTPSAASDWNHVDTQPEQADCESRAPSRAQSLDPVPQGSSPKPSGSSAPLEPSLASQPTVAPEPSPTDSQPNVAPTPTYDHQVPPIAPTPTELPDEETNAPDPPSRPSSQASNRTTRKRSATVRPRGRPRKTTTGGNTSGLDEATEGEEGPTKKRAKTTKADKSVARPFASEPGSLRVAASTSSSLRNFRPVASTGEGATAGHPQEVPRAPTPVPQGEPAVGPPLREPVQSKLRQQSAPVQQPASAFYSDSRLQPLSPSQEDRRSPESLGPTPAYSEDSISSSPPGQRATPFMRSSPPPSSPVLPPMPSAEPQNDDSSFAIDDDMEDLFGEEPPRQPPPRVTTSTNSVRLAKSDPKMTRGIPIQVFQMQGGPGDQDMVHFCSYNGAPVPSSDPPEHQPSAVSDSLSLPVLAKDPGQEQARTRPLMEPTPPPTTDSSEKPTSPGHSTGPVLHGAQPDPATAAAIAHADISNTDSSLEEIDVDKPTMQRPPLVQPIIRRHIQASKAPSFRPLVRSQSAGAMPLALPSAPASEPVGPSSLSQSVTAGARHPAASVAPEQRRAASSGPLILPMPASDPVGPSAQVEETEQRCEAAAPSSPAPERFNKNRVKKRAIKQRLEEAIQNGEMPPFCSNCGAIETPTWRKIWVQDHDGTPSYCEYSEKPGKVTAIEILTRDADENPLSYRLVKKSLGAADDKSAWQELLLCNPCGIWLTKCKCHRPPDRWDKDLLRVGQERRRKATGVANPRPRKSRSKSEAAANPTSDAHPTTDALGIIEEPSHKAAGAELSVEDTEQQSEVAPEARPPSGDVGSKSGPSQTRGSGSATSPVQLDFDEAVGTTKRLLFPSPRKDGVTKVLGEVEVNRVQASDDSQPPKRHADDKENDTGGDEDGAKDVAGVTEVPQWPLGERPSTPPPGASAKTTSPFKTPTRAPSSHRPVTRSVSRSLRSNRSAASPGQVHLQQTPTKTPRNPSGAQGSPSARHSPHTHHDAFEGCDTPISRTISQMFSDPANFGLPDDMDLVTLPALDGDASNLIDFGNLMSTDGLMAPSSPLRGDSTGFDYLNSANMWTQWNLEETPAEGQMSEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNX6</accession>
    <name>A0A367LNX6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_2134</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNX6"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI16144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="128" mass="14243" checksum="CCD9E099CAD330D7" modified="2018-11-07" version="1">MLETPGSGGATTHTLSALYLSLSTVRVSPSPRRLGHHRLLFGFIFFFRFKAPTFVPCITKSQLRPVYATGWESPCKKETEGGLLIVLAYGKEKKIHKQERGWVRGRSLKKHNLLQPSDEEEGGGGTEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LP25</accession>
    <name>A0A367LP25_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LP25"/>
    <dbReference type="STRING" id="1330021.A0A367LP25"/>
    <dbReference type="OrthoDB" id="5423493at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="561" mass="61156" checksum="28A4031B5F48B4FA" modified="2018-11-07" version="1">MPRPKKARREPPVASNDETVRRRGRPRKSTAPPNLADETVLGAARRKRDAALDTLAKEDATSSVVGEGGRAVTATPLHRRHNDSGLDLADDDVFGALDDDFADDSLTSSAADDGDQQRRRRPRSRQSSIVGPNDPPIRPSSRGPNTPGIGSSFNVGLFRRRAREPSILGTSRKPLPERKGEVMDEPSEERPTPSSLSRSRKRKSGGDDGDDGDDDDDNNDNARENLAQGSSSSSLSDVVIDSDSDLSVLASPLTAAMASLPSAPRPVTPTNRNEKDDDEVAAPPASSGSENDADAGWPDIHGLAKRRRRPSALMMMPTLQTDGHHEESDDNNNNNNMSSPPSLTHSPNIAASTRRRGRGIRRRRASSPPKLTTEHLTNLLPKRRQRKRLRYSPSHSGSDGELDTTDLAPDEDELAHLDVRSRRGARRPRQRDGVASSAHGEGSVLKPRQTASSTRQPRAAAAAAAKARKPHTRRSSDKENEDEDDENEDDDDDDDDDDDEGEEEGESALVPLPDNTFDSTPDAACKPADELKKAARKFKEVDRWELDFEEVTESPSSQDAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LP68</accession>
    <name>A0A367LP68_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_2202</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LP68"/>
    <dbReference type="STRING" id="1330021.A0A367LP68"/>
    <dbReference type="OrthoDB" id="431497at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03272">
        <property type="entry name" value="ABC_SMC3_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000370">
        <property type="entry name" value="Structural maintenance of chromosomes 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000424">
        <property type="entry name" value="Structural maintenance of chromosomes 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041741">
        <property type="entry name" value="SMC3_ABC_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="10">
        <location>
            <begin position="522"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="179"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="260"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="399"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="694"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="850"/>
            <end position="926"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI16177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1200" mass="136708" checksum="8343CC3F2281819F" modified="2018-11-07" version="1">MYIKQIIIQGFKSYKEQTVIEPFSPKTNVIVGRNGSGKSNFFAAMRFVLSDAYTQMNREERQGLLHEGSGSAVLSAYVEIIFDNSDDRFPTGGKEVILRRTIGLKKDEYSVDRKVVTKNDVMNLLEAAGFSRSNPYYIVPQGRVTALTNMKESDRLNLLKEVAGTHVYETRRAESLKIMNETNNKREKIDELLEYIKERLGELEEEKEELRGFQDKDRERRCLEYAYHHNEQMTIQSTLEDLDSARQDGLDTADSSRSELVEGEKALAKLDAEMHQLQRDSEMLQIDHRQHDEDRRDYSKALAKAELKVKNLEEGQSAQEQAQAKHAAELESVQANMTAKEKELAKVLPQFEKKKREGDEIRRQLDAAEASRARLFAKQTRGSRFRNKAERDAWLREEINELDLTISAQKANKLEAEEEVARVEASIRESQEEVDSLRSRLRNWSSERNQQFEQVSQARLTLDKLNDERKLIRREDDKLGSVIANARQERDQAERELSHVVDGATARGLATLRRLRQDQDIPGAYGTLADLLTVSDAYRLPVEQTAGASLFHYVVDNADTATYLADILHRQRGGRITFMPLAQLRPRQANLPRSNDALPLLSKISYDTKFDKAFRQVFGKTVVCPNLTVAGQYARSHGVSGITAEGDTTNKRGAMTGGYIDPRKSRLEAVQAANKWREEYDRLLSKSRDIRSQIERKDQEITAAMSEVQKLEQRLRQADDGLEPLNHEIRNKSAHLENEMGHLDAAHKRRDAVEKNMNGFMEEIAAHEAEMSTDFKKSLTAAQEQQLEELSVTVQQLQKQWNEISDGRRKLEKSKQLLEVDLRQNLQMKLDQLNSQAFENSASGASAGGMKEARRELTRAQKALRSVEASLEVVEGKMEELNERTEQVSGEKAKLEQTQSEISSRIERQQKRMEKTLQRKALLTAQAAECAKNIRDLGVLPEEAFDKYENMEAKVITSKLKRVNEALKKYKHVNKKAFEQYNNFTTQQDHLMKRRKELDASQGSIEELVEHLDRRKDEAIERTFKQVSREFATIFGKLVPAGHGRLVIQRRTDRRQDDDESDDEEARGSVENYIGVGISVSFNSKHLDEQQKIQQLSGGQKSLCALCLIFALQATESSPMVIFDEVDANLDAQYRTAVASLLESISNEIGTQFICTTFRPEIVHVADKCYGVTFRNKTSGISCVSEEDALNFVEGQAKPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LP74</accession>
    <name>A0A367LP74_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Saccharopine dehydrogenase NADP binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_2207</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the saccharopine dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LP74"/>
    <dbReference type="OrthoDB" id="10268090at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051276">
        <property type="entry name" value="Saccharopine_DH-like_oxidrdct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286:SF5">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="2">
        <location>
            <begin position="5"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI16181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="414" mass="44721" checksum="57CA9052C7918A10" modified="2018-11-07" version="1">MYDLVILGASGYTGRLTAEHVAAHLPSSTKWALAGRSKAKLQAVADECSRLSPTMSKPELETVNVDDEGQINALVRKTSLVITTVGPYFRFGEGVVRACAQAGTHYLDCTGEIPWVASMIKKYEAEARQSGAILIPCNGIESAASDLITWSLVSFVKAKLGVGVEDVVLSVHKASVVPSGGTIASAMGVFDHFTLAEMRATREPYVISPVPHPNKPRPTSSLLNQVFGIRQVPDLGLQATSIQASIDAPVVERTWGLLSQVPSRKAQFYGPKFNWATYQKPRNWLHGIAMHWALAVGALVLALVPPARALIVKLAPEPGEGLNKEGMAREEIEYRGTATPDAPGPMDKRAYCRAVFRGSSYQITALFLAQAAQTLLEDKTELPGGFYTPACLGRGYVDRVNRAGFKIDVKMLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPK0</accession>
    <name>A0A367LPK0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_2450</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPK0"/>
    <dbReference type="STRING" id="1330021.A0A367LPK0"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024319">
        <property type="entry name" value="ATPase_expression_mit"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12921">
        <property type="entry name" value="ATP13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="13"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI16374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="680" mass="78133" checksum="1ABCBCA6305E44E3" modified="2018-11-07" version="1">MASLTSSRSLLRRLRLGRFPRPRTPRRHRPPGIAPPSQNLLGSDHGEQEHADVDHLADLLSAVQRQDPRQTSQSFIAWTSLISDRSSPRHALAVQQARELPATTLSEMIRNLDPVANPRLDVAHGLNISSGMTQFTSACNLVDEFGVRRHHRQVLAGMTALLKVRAVSPSDCEVMMRCAGAGLNIRQVKRFWSAPVRLGLKKYRSPKTWIEFIKGRFMTEPLYYQFDRARIAVLPRDLQRSGSRRMPNAIVRYLDGLRMGRSVLQFEPWNRQHWRPDQDWRRYLRHTGRDFRSYGAHFRRAICYPTTIDEEFLCVSMVAFARSNGQRAIREEILTYHYGITFFNTKKPPGLRPAGGRELRPDHPIRPTARLLDAIVESFGAMSETLLGLELVQFVSQRWKVPIPARTWSNLLNWTYVCATKPLRQMRRFFDRGEMGAASMRDISHVWSLMHSHKIEPSFDDWCCWARALITVRAFASAVPAITDHMVPHFDALDAEYRAAVLEELLTNENAVDRPPSHRRLEAQARKDHARTAISHCLHQLLKVASRTPRHRAGPVMQCLVPDLIRDLPDFFPPDIVYRSSQGLIQLGQPDAPRRFRWIKAWRTALPARYSALDIPEDSRNWADDLWPEIQDMRILGWHRLPTERAGSLDRAPPRRRASDVAGAGESSAWIRGLRRELML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPM4</accession>
    <name>A0A367LPM4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPM4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="114" mass="13343" checksum="FD97A7BBB8F9F5E7" modified="2018-11-07" version="1">MSIHSLSLYVGRGRERGRERERQRERQRETERDRETENQPDDWKGSYSLNRERGAGDVSVLIEVSLSCMVLSLSFFLYHYPEEWTDETGPFHGKTTTTNITREYINNQVGEGNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPN5</accession>
    <name>A0A367LPN5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase</fullName>
            <shortName evidence="11">HMP-P synthase</shortName>
            <shortName evidence="11">Hydroxymethylpyrimidine phosphate synthase</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_2565</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-(pyridoxal phosphate)-L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + L-histidyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + 2 Fe(3+) + 4 H2O = L-lysyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + (2S)-2-amino-5-hydroxy-4-oxopentanoyl-[4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate synthase] + 4-amino-2-methyl-5-(phosphooxymethyl)pyrimidine + 3-oxopropanoate + 2 Fe(2+) + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:65756"/>
            <dbReference type="Rhea" id="RHEA-COMP:16892"/>
            <dbReference type="Rhea" id="RHEA-COMP:16893"/>
            <dbReference type="Rhea" id="RHEA-COMP:16894"/>
            <dbReference type="Rhea" id="RHEA-COMP:16895"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:33190"/>
            <dbReference type="ChEBI" id="CHEBI:58354"/>
            <dbReference type="ChEBI" id="CHEBI:143915"/>
            <dbReference type="ChEBI" id="CHEBI:157692"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:65757"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Cofactor biosynthesis; thiamine diphosphate biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 11">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the NMT1/THI5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPN5"/>
    <dbReference type="STRING" id="1330021.A0A367LPN5"/>
    <dbReference type="OrthoDB" id="434407at2759"/>
    <dbReference type="UniPathway" id="UPA00060"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13650">
        <property type="entry name" value="PBP2_THI5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027939">
        <property type="entry name" value="NMT1/THI5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015168">
        <property type="entry name" value="SsuA/THI5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31528">
        <property type="entry name" value="4-AMINO-5-HYDROXYMETHYL-2-METHYLPYRIMIDINE PHOSPHATE SYNTHASE THI11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31528:SF1">
        <property type="entry name" value="4-AMINO-5-HYDROXYMETHYL-2-METHYLPYRIMIDINE PHOSPHATE SYNTHASE THI11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09084">
        <property type="entry name" value="NMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SsuA/THI5-like" evidence="12">
        <location>
            <begin position="77"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI16405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="393" mass="43625" checksum="407E50C1EF0FEE58" modified="2018-11-07" version="1" fragment="single">FDYRSDKMSTEKITFLTNWHATPYHAPLYLAQAKGYFRDEGIQVAILEPNDPSDVTEIIGSGKADLGFKAMIHTLAAKGYFRDEGIQVAILEPNDPSDVTEIIGSGKADLGFKAMIHTLAAKARRFPVLSIGSLLDEPFTGMIHLSGSGINDKVESLAGKRIGYVGEFGKIQIDNVMSRHGLSPSDYTAVRCGMNVSSALIKGEIDAGIGLDNVQMVEVEEWLLSQGRLRSEVHMLRIDQLAELGCCCFCSVLYIGNEAFISRNPEGVRAFMRAVKRATDFVMADPHAAWEQYVDAKPVMAGRLNRVMFERSFAFFSPDLKNVARDWDKVTKYGQRLGLLGPDFEPNYTNDFLGWTLEPDSPDPVGDQRRMAELQRDVACRGGFRRLPATVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPR1</accession>
    <name>A0A367LPR1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPR1"/>
    <dbReference type="OrthoDB" id="10453269at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016735422" evidence="1">
        <location>
            <begin position="18"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="88" mass="8986" checksum="90F3605AF3DDDD94" modified="2018-11-07" version="1">MKLAIAIISSSFLGTMASTACGWKGCPIRGRIASPSASKTDTDRFNNPCGGNFATEPASNHPLPDTLPHGCQRSGRARKTAAAAAAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPS1</accession>
    <name>A0A367LPS1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_2602</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPS1"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI16391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="64" mass="6880" checksum="92A7E2A8373B152D" modified="2018-11-07" version="1">MTGFPLSFVGAASNSPAVLDQGSGGGPWSSIQFNTRTSHHGFQLPFCAGYMKFRRRSCITIVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPT6</accession>
    <name>A0A367LPT6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_1915</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPT6"/>
    <dbReference type="STRING" id="1330021.A0A367LPT6"/>
    <dbReference type="OrthoDB" id="4935043at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF134">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="18"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="49"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI16420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="268" mass="30135" checksum="E6E53F3E660EEE0F" modified="2018-11-07" version="1">MSSPSSNPLPPHHDDPDVLAFCIVMTVVTVLSISLRFSSRAIAVELPQTRSRFQLDDWFALAAVPWIIAQLGISFAAIHEGYGRYLPLLPASSLLRISQYQFIIFFLYNAGLFFTKASALAFLRRIFIAQTSPTWFNVCLWIGHGANLAWFIGIIFGTIFICHPINKNWDDSAPGYCGETSSLFMGSSVPGVIIDLFILVLPLPRLLGLRVNLCRKIGIMVVFIVVILSLGRMITMLEYRWFIGSRQSLQSPSWWSVFRPCCHWVVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPV7</accession>
    <name>A0A367LPV7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitination network signaling protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_1913</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPV7"/>
    <dbReference type="STRING" id="1330021.A0A367LPV7"/>
    <dbReference type="OrthoDB" id="4158994at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="352"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="400"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="763"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="830"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1076"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="562"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="839"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1089"/>
            <end position="1117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI16417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1138" mass="124186" checksum="6A44C3A76C4D58D0" modified="2018-11-07" version="1">MPCDAGSTRFGSANACTHHGYCSCVTVTALIKQMDDSGHLSMQTPPHHPHPNPPPPSPRPRQQAQHSNLSTLPPQYSSIRSSLFSSAEAIPLVFLFAGRNSFTTVSGEEASNGISGKLRPGLTLPWSFALPVLGPASDLGHGLKEKPSDDDSALSSPSPASNPILLLLLPSHPRFPSRLRGFGATRSIAHSGKRQLGAGTGHRDVRHDNGSVGIGRRISANKNCGFLNGSTVCSDSYASLSQPPSPPSLPPPSSLAPNGLVNGANQVKKRPDDAAVPPGLDLRPGHALRRRSLDAYSETSSESCLSSLGPGPEGGHRQIDVNAMKNADVHRDSGPLDLAATVVRSLPVQDTLAILIILMHIPYLSLTLVYACFASLTFVPPVATRVGWNISFGEIIDGNSHAPSLVTAVCMDFFFFLIWVFLWPPIQDSILEFAKPVIAVTLGGGTSAKNGTSQGVTACFAWVLLHKLVRASKRYWPRLAYHLPDAWRVRVVLDGSLSTAATATTSAPTLHAPYDKRDTHGWIQSVLAIHILTQGIVRYIREWYLRRERFHAAAGLGDPEAAKSSAVAGGSNASGAGDSAQDANSNAAPDAETALSSHSVGMIKKRRKQNAQVRLQQPLWSALASSKIVVMKEMELSSWCSSSSDKRDIHNAGNMPFFDRQPRQIWISYIGSDEVCFSTSHFPETADEEPSCAAPAGVDTMKPFYVRINEAYWQPTRIFPTGDGKWSGDIYALRPSSKYVCEFVHVQTDQVLFTTSIRTIKEPLRDDDVSSPGQSNGQQPLRPDSPATTLRTSIVAAESRLADERNRLKTWRKEWKIRINTLKKENELAENQLSTAGNNDERYRQKIRQQETQKAQTERDTRRLSDQLKQLDEAWPELVERKKKVERAFSAEKRIFDATQKELKEHKSQLAKDIKAKEAERCNLNARRNKIASRIAKIDTELANISDSNSRGQGEAERRRQERSRWLEQASAVEHGYTERLAQQVAINHRRREHLRELQARLHSMQSYSLKPANGMKVEANASVAAEAGPASFRRTSPWNASPLTAANYPWATPAPEAMGSRAPNMAARLSSAASPAFDNARGARTRVRSSSMLSDVSGFTQASDEGSVRQRVQQASVFAKKRNGSSGGGSSSDSATG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPX8</accession>
    <name>A0A367LPX8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPX8"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="74" mass="8307" checksum="8792868D4994F3CB" modified="2018-11-07" version="1">MPLKRTSIDIQIPFLPPSPLDSMNLPGKETAPPTSPRKRKQDSTREAEKELSLFLSPTFPLSFPATSYRAFFPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPX9</accession>
    <name>A0A367LPX9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ER membrane protein complex subunit 7 beta-sandwich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_3275</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPX9"/>
    <dbReference type="STRING" id="1330021.A0A367LPX9"/>
    <dbReference type="OrthoDB" id="27095at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019008">
        <property type="entry name" value="Beta_sandwich_EMC7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039163">
        <property type="entry name" value="EMC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13605">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13605:SF4">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09430">
        <property type="entry name" value="EMC7_beta-sandw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016721944" description="ER membrane protein complex subunit 7 beta-sandwich domain-containing protein" evidence="8">
        <location>
            <begin position="22"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="ER membrane protein complex subunit 7 beta-sandwich" evidence="9">
        <location>
            <begin position="35"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI16486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="259" mass="27719" checksum="878CFC47158D789A" modified="2018-11-07" version="1">MRLPKLSLLSLITLLLNDATAKPTKLTLYLPTLPNANALPSRTHATLSSQGTHLSAPLTTSNAFVFQGLPPGSYLVEIHCPSLAFRPLRVDVGRRDGEGGREREEEEEEGRELAAAWETFRGNDWANKGEALAVVRGVFGAGFELRPLGAKAYFVERPGFSVLGILKSPMILMGLASMLMVFGMPYLMDNMDPEMKAEFDAQQRKGGPVASIMGGAGPASGNPLGDFDMAAFLAGSKKKDAPPPPADGDAAPRQQGVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQ40</accession>
    <name>A0A367LQ40_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1736</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQ40"/>
    <dbReference type="OrthoDB" id="3539922at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="220" mass="22706" checksum="0C5CE55CD87E8498" modified="2018-11-07" version="1">MIIIIVDRDPLLTCRRRGSLDTDVIVIAVIGAVLLRKMIGTSTASVAASALLRTTTTTSTTNSTTNDAPAVQTIPTAEADGDDVELPPAAGPSHEETITPSQRRSSVPSNIVKKGQQWWANPLVKAGARTAFSAGAQAAMQSRNDPSPWLGAKGAKVATAALGAALVDGFMAEKHPNAVRTEALRHGRDAVLGEAARRSAMERSAAAAAGGGGARASRYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQ71</accession>
    <name>A0A367LQ71_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_2956</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQ71"/>
    <dbReference type="STRING" id="1330021.A0A367LQ71"/>
    <dbReference type="OrthoDB" id="4926461at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="63"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="398"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI16595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="662" mass="72710" checksum="253F071D56AB76E5" modified="2018-11-07" version="1">MAVDCFEIVFRSEAKSTHVQPATRGGSFSRKGLFHMMLLLLLLLHLSVIIGLLVDRGHGSPWKPLSKVRVQPRRPAAGTRSHPPNGGARLREHSPTTSDGYLTPAAAAATTTTAIKLPSRPDKLDLDLDFDDTVKPFLETVLGHVYEPTPDSPPHVYETIAGAEEPYYLDIVDGPPKPPARDSDVQELRRLALSSRDRAVEAENDVGSALEVDDIEEAMLKADRAAEEAFRSAQELGLLKGAGVDMEKQRMEFDAALRATVDARMAAARARSRAATLMIDKCFPERNEKWALITRMASMRMEEAVHYQQKMEEAARQLNEQISRFHQFTKELSRRQGSLIASWLSEDNNNNNHYIKLWSERDIEAINREKQFIDVVTEMSKSALKELWEAAVTALDLSDKFTRAIESARERARQEEMQQAAKDAKERQQKEAMALAEKQREARLRRELEAEAKKEATSLMEKLQGMEEAKSTWWTDLMIGVTTAISTVPFGIFLYAVVTSSSSTSGLGAAAVSVATSMAADTTTAMGAAGAAAEEAVSQVLEDALGTAEAALVGLSHPVVSVGADTESILSQMTSESLPHIMGEMPVVSELADSVRHMLTTTLRRRTTTTTGTTTTTTTRDEAVAALLRRDEALRGMVVDAVMDVMQEAIQGAHVAMFGEEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQP7</accession>
    <name>A0A367LQP7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_1717</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQP7"/>
    <dbReference type="STRING" id="1330021.A0A367LQP7"/>
    <dbReference type="OrthoDB" id="5598695at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000087">
        <property type="entry name" value="Transcriptional adapter 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374:SF21">
        <property type="entry name" value="SWIRM DOMAIN-CONTAINING PROTEIN FUN19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTOR 2 ADA2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SWIRM" evidence="2">
        <location>
            <begin position="390"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI16773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="487" mass="54066" checksum="C2B43BCEC084FE73" modified="2018-11-07" version="1">MADKPVHGHPHSLSAFDKSPTSVATWQAVANQPNNVSLSAFPHPAPNPRPLDSLKTSMAPPPLPTASLEPKKVVISSLMSPPDAPLDSFAPVAAKNMSANNAPPSAHQPLEESPLQQPLPMSPPVSPYSKPAIANTSSAAPQPPPAAPPSVHQQVKDPVLYPAEESSPTSPPHPPLFAPAEVDHRRIVDQHMRARPQNIFANVSPPCREDYELALIFRSQVMKHYTADRKAWLRKERAFLEADRQASAHRHHAIVLAKPVAASKPSRPQRDRVTKAQPVNPRQMRNHSQQQHHNQQQVQGQQQQQGRQQQQQQQQQQQQQHPHHQVLHHVAAAAPPATTVPAKAPAAVRVSATPEPSRRIVAPNREDKDFDALPNFCPPASSLPNRANSLKVDWKGQPIDLSNDRNAHLLHPDEVMLAGNLRLDCATYLTSKRRIFERRLQCLRTGKEFRKTDAQQACKIDVNKASKLWTAFEKVGWLDAEWVRKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQV5</accession>
    <name>A0A367LQV5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_3032</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQV5"/>
    <dbReference type="OrthoDB" id="10617163at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI16844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="95" mass="10613" checksum="1C2EFED4159D0DAE" modified="2018-11-07" version="1" fragment="single">MADELFSPVPRGFRGRVALPLQLWGAGYWSCYPPRRLGRAGGLQQPCYAGTDRQESGDPLSMLQKSLFLCRTSRRLLLLLDPIIITMANARCPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRQ4</accession>
    <name>A0A367LRQ4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_1803</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="STRING" id="1330021.A0A367LRQ4"/>
    <dbReference type="OrthoDB" id="421009at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
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        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15844">
        <property type="entry name" value="SNARE_syntaxin5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.70:FF:000007">
        <property type="entry name" value="ER-golgi SNARE complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021538">
        <property type="entry name" value="Syntaxin-5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF3">
        <property type="entry name" value="SYNTAXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11416">
        <property type="entry name" value="Syntaxin-5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="231"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="176"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="180"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI17099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="323" mass="35660" checksum="B52A745DA9E19CD5" modified="2018-11-07" version="1">MAVASIQDRTAEFKSVLAQAQRRQPSNKVGSKRRSLLSDSQKAAAAADGDAKTPRRSDFARKAAEIGRGISATMGKLEKLALLAKRRSLFDDRPVEINQLTFVIKQDLSSLNQQIGSLQTLSKQQHSKADQEGEHNKNVVYLLQGKLTDVSVNFKDVLEARTKNIQASRSRTENFISSVSQHAAQPPLQPSASPLYGTPNRASPAPGSDTLSLNPVGDQQLLMMEEAQQTNTYIQQRGEAIEAIEKTISELGSIFGQLATMVSEQSDMIQRIDANTEDVVDNVEGAQRELLKYWSRVSSNRWLIAKMFGVLMIFFLLWVLVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRU2</accession>
    <name>A0A367LRU2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein bL33m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_2690</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRU2"/>
    <dbReference type="STRING" id="1330021.A0A367LRU2"/>
    <dbReference type="OrthoDB" id="275534at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.120">
        <property type="entry name" value="Ribosomal protein L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052008">
        <property type="entry name" value="Mitoribosomal_protein_bL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001705">
        <property type="entry name" value="Ribosomal_bL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038584">
        <property type="entry name" value="Ribosomal_bL33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01023">
        <property type="entry name" value="rpmG_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47037">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L33, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47037:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL33M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00471">
        <property type="entry name" value="Ribosomal_L33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI16952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="59" mass="6783" checksum="67DA8F9C46207A86" modified="2018-11-07" version="1">MAKKAKPRLINVRIISMAMTGFFYTVKRARKAPMMGLLKYDPIVRAKVLFLETKKRPSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LSA8</accession>
    <name>A0A367LSA8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_2288</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LSA8"/>
    <dbReference type="STRING" id="1330021.A0A367LSA8"/>
    <dbReference type="OrthoDB" id="10261046at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000001">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="7">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI17277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="188" mass="20685" checksum="6C79CA1FFD77E5FC" modified="2018-11-07" version="1">MINAFLVFNGQGQPRLTKFYTQLARMQETNIQQRLISEIFTLVSNRPPGACNFLPLPPLLAASGTSHTSSHEESDVPSLVTYRNYATLYFIVISTSTESPLALIDLIQVYVEALDKLFENVCELDLIFNFETLHATLSEMIIGGVVIETNMDRIVSGVKAQGTVAKRPVNEGRATSLGMAGNFAWAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LSP0</accession>
    <name>A0A367LSP0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sister chromatid cohesion protein DCC1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2891</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LSP0"/>
    <dbReference type="STRING" id="1330021.A0A367LSP0"/>
    <dbReference type="OrthoDB" id="5199543at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019128">
        <property type="entry name" value="Dcc1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09724">
        <property type="entry name" value="Dcc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI17407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="127" mass="13711" checksum="B7A0CD343739C411" modified="2018-11-07" version="1">MPTTTDTISIPLNHHPPSTNYRLLELPPEVESLLDTSTYPALTLDDAPGSASAILRTQDRTYALRQKNTSNALLVLSSSSDNAGIAVVATLHEVVELDALPSTPVHTGSLSHTGSRGKWHERFGKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LSW4</accession>
    <name>A0A367LSW4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_2650</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LSW4"/>
    <dbReference type="STRING" id="1330021.A0A367LSW4"/>
    <dbReference type="OrthoDB" id="3971593at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="334"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="630"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="689"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="23"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI17467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="724" mass="80918" checksum="2461E8ED1E8896CC" modified="2018-11-07" version="1">MEQIETQASDLRFLARQQQQQQIVDSPSYDDTPSNAQQTASPPILLAGDNSAGKRKAADEGAQQRQTRSKRNRRRKIKCNGETPCQRCGNLNLACLYAPNCCSNSFRDSDEFKHVVAQLGQLQNEVASLRQTVGLVSPVAFSSPAVASSQRQPSSVFVGSTSTVFDIDVANNTIANMGYRYGDDDAGSSDHCRSSADVALPAPCDPLFDFDKDEVLRLCHFYEDELGVMYPVLKVQAVIDHARHLTPILADARSHQRPPEAINDDKTLQLKMVMCCALVIEQHGHSEKATHLFKSLEDAVNRKLMGEVSSSVANLPLFCLVAGYRFLSNEEILAWRVMGHVVRLCVELGIHQKRGLMGIRDESDRANALHSFWSAYILDRRWAFATGLPFTLQDDEIDPQLPIPDNHPFLVAMITYSRLGAKVWRQGSHFGPALARELRQEEMENLDREILHWWDTVPADIKTQHRKGSPLEATCGLHRLGIWAYLRFVQIRIWLYTPVLHSATSTLANTPQSDLVVNLARDTIRYLDHLNRTTNLYRIGQVFYHQFLASALAVLFLASVHVPVRFSGMCRDEFYMALDLVKDLSAKSWVSKRLWCTIKSLKDVAPRFGLSPADAASRSAASLNMTTFPSLDMTSPTHHHQQSPSPLQQQNESQGRNEDSAWSEHLGGRELQTQLSRIYEDYVGSSTSEGQAALAASSSPPSPGTSRDVFDADDTIFQQLRDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LTK8</accession>
    <name>A0A367LTK8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit delta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_2059</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LTK8"/>
    <dbReference type="STRING" id="1330021.A0A367LTK8"/>
    <dbReference type="OrthoDB" id="10254737at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233:SF14">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI17462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="419" mass="45807" checksum="35558F880855EBBF" modified="2018-11-07" version="1">MASESSAADTKKKRTTNEAPGTNEQLLSNAERKKKAKEEKAARRAAAKSAPPQQAQQQQTTTTTTANEQPRSAVGSTTRTRVRLDGASTPRPQVPECFSHLSMARRLAITQADKDVHPTVLALGQYMGCFAVGDSITRLEATLLAFKKVIDSYTTPHGATFSRHFTSHVLNPQIDYLAACRPMCFSMGNAIRWLKLQISKLDIDLPDSEAKKHLRDLIDSFISERITLADFVIVKTAAEMVSEGDVVVVYGRHHLVERALLKARSQGRRFKVVVVDDAFERVGIDLAKVLAKADVAVTYMSDLGALRTTLSRATLVMAAAEAMFSNGAMYARAGTCDVATVAADLGLRVVALCESINFTERVAIDSLTYNEIDPESCHAEGFRLLFDTTMHRYISVVVTELGTTSAKSVPAILRKVEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2024-05-29" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZC8</accession>
    <name>A0A367KZC8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_8319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000027">
        <property type="protein sequence ID" value="RCI07516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZC8"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI07516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="77" mass="9222" checksum="8A88EDC9C2DF5592" modified="2018-11-07" version="1">MATSYGHTTIHIFLLCRKISWENLRGKKMWKESFAGYFLNIIQLYKNSLRSAQYHLPGCYFLRCHITLEVECLHFHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZR6</accession>
    <name>A0A367KZR6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_5759</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC12A transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000024">
        <property type="protein sequence ID" value="RCI07668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZR6"/>
    <dbReference type="STRING" id="1330021.A0A367KZR6"/>
    <dbReference type="OrthoDB" id="2020542at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015379">
        <property type="term" value="F:potassium:chloride symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006884">
        <property type="term" value="P:cell volume homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055064">
        <property type="term" value="P:chloride ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055075">
        <property type="term" value="P:potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034486">
        <property type="term" value="P:vacuolar transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000013">
        <property type="entry name" value="Solute carrier family 12 member"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018491">
        <property type="entry name" value="SLC12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004842">
        <property type="entry name" value="SLC12A_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827:SF72">
        <property type="entry name" value="GH08340P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11827">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03522">
        <property type="entry name" value="SLC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="352"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="437"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="26"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="SLC12A transporter C-terminal" evidence="10">
        <location>
            <begin position="502"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="840"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1050"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1054"/>
            <end position="1069"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI07668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1271" mass="138688" checksum="488C4C0E7E2F7B19" modified="2018-11-07" version="1">MSPPPATGAGPDPARNGKLGVMSGVFIPVFLSIMSILMFLRFGLILGQVGLVGIAGLLLIAYCVDVLTTLSLSAIASNGEVKGGGAYFVISRSLGPEFGGSIGLLFFVAQALNTALNIIGLIDSIRLNAGDAFPSGYWTGYLLQTAALVLCTGLCLLGSSIFSKASAALLAILTLAVISIPVSLVFKTPFHDKVSGVEFTGFSLDTLMSNLLPSSGDPEYQGLATFRKLFGLLFPATAGIFAGASMSGDLINPSKAIPAGTLWATLTTLIVYVLVVFSMAASTTRKSLLTNNNVLFLTNIFPPIILAGECSVTFVSALICMMGAANLFQALARDRVLPGLSIFGKGSRKSDVAFTAILLTYVLIQVALLADLNRIAALISMGYQMTFLVMNLACFLLKIGSAPNFRPSFKFFSWQTALAGSLLSTAAMFFIHETYAAVAICLLCFIFLLIHYLCPPKRWGDVSQNLIYHQVRKYLLRLKPEHIKFWRPHIILLINDPRRQTRLIQFCNSMKKGSLYILGHVIVTENFDSGVEEARLQQQAWTNYISEFSRIKAFLQLTMSPSLVWGVRNLILSAGLGGMRPNIAVLGFYNMDDLRKSKPIIPVPDLPETSFKTRRAFWADGKAPVRRRSDVSSRLLAGSLPTDVIRTEGPMSPTDYMLVLEDLALKYRLNVAVAHGFESLETPRDDGANTKKYIDLWPIQMSAEVAADGKNVLTTNFDTYTLILQLGHILRSVDHWRRVYTLRVMVFVEYESEVEEEAARLKVLLERLRIEAKVLVFWLAAGHLGTYELIVNGRTDDSRAQDIVDDALQYEEWWDDLQAYRGQAGGNGSRREAQQLVQSLDAAAGRPPNSNPFDESGSNRRRHSLAEVDGMPRYHGVGLLHKWGVNVGIHTHHLPEDVLREPQLNDTLRTITECSDSDEEYDLDSEPVLTVKPVGSPKRPLLMKAYGQSDSGPSSALRGEIEARRWAEAEASQSLSYGTLLPDRYDEGALRGIPRVVATRASPPLSMESFPALHAPVPMRPVVALDTTDRSRSPSPTRVTSVRALGEGHVTPVRPSFSRQSSASRFSCRPVPETRVVAEAEGPKLGFAPADSRSASQRAERPAFSRQSSWSRAIGWPPIGPRADVADESPAGVGHAGETPSTPLPRHHSRHSSQHSGLGGEGVSLSMPELCESYRKKQAATDDGSTYSTQSVALSFNDLPSRAQHLILNELMRQQSKDTAVLMSTLPIPSEGTSLDEAATIRYLSDVEILCHGLPPTMMVLSNSMTVTVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZY8</accession>
    <name>A0A367KZY8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_5691</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000024">
        <property type="protein sequence ID" value="RCI07717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZY8"/>
    <dbReference type="STRING" id="1330021.A0A367KZY8"/>
    <dbReference type="OrthoDB" id="5580261at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018811">
        <property type="entry name" value="MRX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28002">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28002:SF1">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10306">
        <property type="entry name" value="FLILHELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI07717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="199" mass="22627" checksum="51A15568771A92AE" modified="2018-11-07" version="1">MFRRAIFARSRPRPPSRTTHLSVPSSSRSSSSSSRRIDKLTSKLPARFQKYAVRLRNAPFSHVVAFLVLHEITAVVPLVALWALFHYTTLVPLEFVAGRFAAYTDAGVAKFERYFRRKRWFGFDGEQPGQPHGPDQEHTHQVMQRRESGDRSYKILVEVALAYAVTKALLPLRIVASLLAAPWFARVMTSIGSSLFRKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L000</accession>
    <name>A0A367L000_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5703</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000024">
        <property type="protein sequence ID" value="RCI07773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L000"/>
    <dbReference type="OrthoDB" id="10333146at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI07773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="208" mass="22894" checksum="A875A352FD149CAD" modified="2018-11-07" version="1">MYELGDLCVVLCAGDAIQQEGVRSDSLGFRKLICQLSATCLLLSALACLHTVSAFPAGNIGFNAAKQTPLGMYIKLIEEEGQVYKAKGWSGTGNEAFPNLMHCLTDLPLKPMLAASIDRPAFLKHVLGGEKQYHEFLTKFLRKDKAVRLTLMSRIEAPVSPVCVPGSTPLGPMEHMDRSPGWEPPEEAYQVVSAWDFLTRKEYSNIGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0B1</accession>
    <name>A0A367L0B1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_5807</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000023">
        <property type="protein sequence ID" value="RCI07854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0B1"/>
    <dbReference type="STRING" id="1330021.A0A367L0B1"/>
    <dbReference type="OrthoDB" id="206335at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000019">
        <property type="entry name" value="RNA exonuclease NEF-sp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF115">
        <property type="entry name" value="FI18136P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="8">
        <location>
            <begin position="275"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="462"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="557"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="559"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI07854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="691" mass="76459" checksum="A91855421E2A0528" modified="2018-11-07" version="1">MEQQAEQDPELSPLLSDGSLKRTSPHDEDDDQAAAEWQVVTRPKKKQKKIPQPGKSYPNFTFSKKARLSSKLNLSQLRDLIIYIFADGPAPQWITVGHRPQFRKIVAIMIPGLEEAMFTEHVDFSAYGDSATKLLSDADDFYPRPLDKEKTPRALQFFADTFPLLWPVRAPGDDKFARMHSPLAAMLTAPPPREKTAKVEEVQWKNERTPITEFLLSVDNLEENNYLIHPALLRGPRREAFVAPEGWVTTKVGSLEEGDVPESEIESGSITAGRKVLALDCEMCMTGDNEFALTRISIVDWAGDVVMDELVKPDKPIVDYVTRFSGITEEMLAPVKTTLHDIQQRLLELLHPRTILVGHSLESDTKALQLAHPFIVDTSVLFPHPRGPPLKSSLKYLSQKYLSREIQQGGPNGHNSIEDARCCLDLVKQKCERGPRWGVSENNGENLFRRLARAGTTYKVQGGDAARGGVETGKTSAAVDWGDPTKGQGAGATHQIGCRSDDEVTEGIIRAVEGDPDGEEIRAGGVDFTWGRMRELEVLMGWCNDRTCAAAAAAAAAAADDDDDDDENDDDDDDDDDDDFEGDDSSKPCFSSSAAGKAPLERALFRLTARLERIYAALPPCTGLILLSGSGDPREMARLQQMHARFRKEYNAMGASASWDHLSVKWTDVEDQALRKAVREARSGIAFMTVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0L4</accession>
    <name>A0A367L0L4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7878</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000022">
        <property type="protein sequence ID" value="RCI07975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0L4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI07975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="301" mass="33656" checksum="93751803DA78AED9" modified="2018-11-07" version="1">MDHEPVLKIRAQDHARVSGGQKHSARCVDVEEVERVAAYEPLRRYKKRERALSSSCSHSDRKHCPSLSSSSQCFTQEPGQALCCCPSRFRLLGAPLPPPSLNPGRRSIRTHNLPSRRHLTKIDRVQLHRRGREAGKYEPGGYHPVMMDDAGYAGKASNACNASDTTPTVPSILHQVDMQGPNGTHTCYTSAPTQAKSQRSIIQSTLSYPSRPGVGRKSSRGTLPWSMEDIHLRNILVNLPPSTLDTAVSRPVQRQSSASLRRYPSAVWMEFRPEERLTVDEVLRSKRMVNRSLNQSLNCDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L115</accession>
    <name>A0A367L115_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nucleotide exchange factor Fes1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_6274</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Functions as a nucleotide exchange factor (NEF) for Hsp70 chaperones which accelerates the release of ADP. Required for fully efficient Hsp70-mediated folding of proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FES1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L115"/>
    <dbReference type="STRING" id="1330021.A0A367L115"/>
    <dbReference type="OrthoDB" id="10250458at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000434">
        <property type="entry name" value="Hsp70 nucleotide exchange factor fes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050693">
        <property type="entry name" value="Hsp70_NEF-Inhibitors"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013918">
        <property type="entry name" value="Nucleotide_exch_fac_Fes1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316:SF18">
        <property type="entry name" value="HSP70-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316">
        <property type="entry name" value="PROTEIN FOLDING REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08609">
        <property type="entry name" value="Fes1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="Nucleotide exchange factor Fes1" evidence="8">
        <location>
            <begin position="6"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI08087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="216" mass="23415" checksum="7D3C2A3ABE349B31" modified="2018-11-07" version="1">MGDKRLNDLLRWGIENSTNDGSPPTAETNSADGSNLTPDVMAALMGGPSDADLMKAAMEVISAPLSDQVSLDDKLVAFDNFEQLIESLDNANNMANLDLWTPLLHQLRSEEADLRKMAAWCVGTAVQNNERTQEKLLAMGGLPPLVSMAVRPDEKADVRRKAIYALSSACRNYQPAMDVCIEELAKDGYASDKIDAKNMEAVDEVMTALRKKAGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1K7</accession>
    <name>A0A367L1K7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 13">Cytochrome c oxidase subunit 6, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 13">Cytochrome c oxidase polypeptide VI</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_6250</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome c oxidase subunit 5A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1K7"/>
    <dbReference type="STRING" id="1330021.A0A367L1K7"/>
    <dbReference type="OrthoDB" id="5778907at2759"/>
    <dbReference type="UniPathway" id="UPA00705"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00923">
        <property type="entry name" value="Cyt_c_Oxidase_Va"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.40:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.40">
        <property type="entry name" value="Cytochrome c oxidase, subunit Va/VI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003204">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036545">
        <property type="entry name" value="Cyt_c_oxidase_su5A/6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200">
        <property type="entry name" value="CYTOCHROME C OXIDASE POLYPEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14200:SF11">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 5A, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02284">
        <property type="entry name" value="COX5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48479">
        <property type="entry name" value="Cytochrome c oxidase subunit E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0349">Heme</keyword>
    <keyword evidence="8 13" id="KW-0408">Iron</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00070174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00082700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI08102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="144" mass="15948" checksum="ED3F6EC0CD5A0E35" modified="2018-11-07" version="1">MLLRAPRATVVAAAAAAVAQPLPCAFRAAFSTSKPTCSEHAEETFEEFTSRFEKEFDGVQDVFELQRNLNNAFAYDLVPSPGVVTAALKAARRVNDFATAVRIFEGIKAKVENKGQYQEYLNELDGLRTELGVPLKEDMYPDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L272</accession>
    <name>A0A367L272_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAR1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_8900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L272"/>
    <dbReference type="STRING" id="1330021.A0A367L272"/>
    <dbReference type="OrthoDB" id="2422440at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47482:SF5">
        <property type="entry name" value="FAR1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47482">
        <property type="entry name" value="OS11G0632001 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="593"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="693"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="31"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="136"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="208"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="283"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="312"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="326"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="341"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="393"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="449"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="465"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI08530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="768" mass="86144" checksum="968012C4F7C837EF" modified="2018-11-07" version="1">MSSLGPSGSNPHAGLSFSQAGLRRTAGFAPSHSNQHQQNKQSPAPHAASPYQPQAYAPQQQPPQGSFTHHIFAPPQNTNGHPSSRAPNNHVPNAITIQRQRGVPPRQQMQAQSNPPPMMFPSGIGQSVQHEPLLSHPQHAQHPQHQQQQQQQQQSHPSSHQPHPGHPAHAQQQQPPTPQQQAQPQPPTTQQQQQQQPPPPTHQHQHPQHQQQQQHHAQQQQAHHQQHQAHTAHQVHQAHQAHPTHPGLPGHPGHPGHPVHQAHPGHQARQSHQGHPLSQQQHKPPPPPPQRQQQHPPPPQQQQQQQPQQPQHSPPQSQPPPPPPQQQQQQQQAQQAQQAQQHHHHPHHPHTHQHPHQQQGQQHHTPQPTSQQQQQSQHQHQHQHPQPTPSQQPTPQQQHTPQPQPQQMPQGQQQPQAQSQQQPQVAQVQQSQQAQASPRQQQQQQQQQQEDEAEQQDDAADDMDMDSHNEGEHEGTGLDSKLLNDPSFVPSQPLGAMMSPPPEGGSYPTLDAVQKAVLRYCTSVGYAIVIGRSKKTVPGLKKVLFVCDRAGKPPSRVSPEFRKRKTSSRKCDCPFGFFAIEQRTQWTIRYRPDPAHLQHNHGPSESPSHHPAARKLDSKMVAAVKQLKENGAGVSETLQILQNENPDCHLLPRDIYNARAAINRNPQKVATGLAENRPAIYTKPQPSSEDRIRAELRRELAKAREDLKKVEEEKQKEIDDLKAKLEEKEKLIQKFEMFIDICNQRVMVQRERLAGQEGNPAAGGNPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2C5</accession>
    <name>A0A367L2C5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Pheromone-processing carboxypeptidase KEX1</fullName>
            <ecNumber evidence="15">3.4.16.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Carboxypeptidase D</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Pheromone-processing carboxypeptidase kex1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">L249_8837</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Preferential release of a C-terminal arginine or lysine residue.</text>
            <dbReference type="EC" id="3.4.16.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.6" evidence="15"/>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2C5"/>
    <dbReference type="STRING" id="1330021.A0A367L2C5"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000121">
        <property type="entry name" value="Carboxypeptidase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF190">
        <property type="entry name" value="PHEROMONE-PROCESSING CARBOXYPEPTIDASE KEX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="4" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 21" id="KW-0732">Signal</keyword>
    <keyword evidence="6 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="21">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016884473" description="Pheromone-processing carboxypeptidase KEX1" evidence="21">
        <location>
            <begin position="28"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="517"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="466"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="564"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="471"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="567"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="584"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="19">
        <location>
            <begin position="606"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00037042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00038895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00040403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00040628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="RCI08372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="635" mass="70892" checksum="0D9B655AC29787E1" modified="2018-11-07" version="1">MILMAAAASYARLCAAAALLLAALVVAEPAAADYYVSDLPGVPKDSPPIKMHSGHVQITPEHDGNIFFWHFQNTHIANRQRTVIWLNGGPGCSSEDGALMEIGPYRVKDKDTLTLNNGSWGEFANLLFVDNPVGTGFSFVNTDSYVKELDEAADQFVVFLTKFFALFPEYQRDDIYMAGESFAGQYIPYIAKAIIDRNAKTARNKWSLKGLLIGNGWVSPTDQYPAYLGYALKRNLIDKGSDMAQQLQGKQRICDHMLVSNPNHVNYDECESILSEMLKLSRTGSGDEACYNMYDVRLRDSYPSCGMNWPPDLKALTPYLRNPAVIRALHVSEKRNTGWQECTGAVGSAFRSKKSKPSIDLLPDLLKNVPILFFSGAEDLICNHLGTEQMISNMEWNGGKGFEVTPGNWAPRRTWTFEGDVAGFWQEARNLTYVLFYNSSHMVPFDYPRRSRDMLDRFMGVDISSIGGEPTDSRIDGEKGPETTVGGASNQTHSAEEETRKKIDEAKWAAYRRSGETVLIIVGITAAAWGYMIWRQRRRGAIYRALRGTGGGGSDSRLAAFRREQQSDDDDDDDDDADLEATAFDERRLDRLHAQSNNTEPPRADSDDDDDDDDDDDVEPEQVDSYKMQTVPAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2U7</accession>
    <name>A0A367L2U7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_4725</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 12">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2U7"/>
    <dbReference type="STRING" id="1330021.A0A367L2U7"/>
    <dbReference type="OrthoDB" id="282152at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10509">
        <property type="entry name" value="Zn-ribbon_RPC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000005">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034014">
        <property type="entry name" value="Zn_ribbon_RPC11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF12">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005586">
        <property type="entry name" value="RNApol_RpoM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3 9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="13">
        <location>
            <begin position="66"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C4-type" evidence="10">
        <location>
            <begin position="5"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="5"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="8"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR005586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR005586-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI08745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="110" mass="12625" checksum="D1B5E6D84A1A7315" modified="2018-11-07" version="1">MLLFCPQCANILSVSLTVHRTNRLECRTCPFEHTITDPVFSRRTYERKEKEDVFGGPGAWDNAQKGRVQCPAEGCDGDEAAFFQVQIRSADEPMTSFYKCMTCGHRWREN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2Y4</accession>
    <name>A0A367L2Y4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4702</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2Y4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="78" mass="8640" checksum="A8E4B9664806B2A7" modified="2018-11-07" version="1" fragment="single">TRPEGLGGSRDAGPAAAGPRPPYVTEASRLRVLWVPSSPRQITEVGTAQQRRRRLQHGYAVQRLRPYGPYGPYEGRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3K6</accession>
    <name>A0A367L3K6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI09004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3K6"/>
    <dbReference type="STRING" id="1330021.A0A367L3K6"/>
    <dbReference type="OrthoDB" id="203724at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024420">
        <property type="entry name" value="TRAPP_III_complex_Trs85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975:SF6">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975">
        <property type="entry name" value="TRANSPORT PROTEIN TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12739">
        <property type="entry name" value="TRAPPC-Trs85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="715"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="763"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="721"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="769"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="783" mass="86361" checksum="46180E7D36DFDBCE" modified="2018-11-07" version="1">MPPVQDEPPPEPIQALPAAAAATVAAAAATKLTNARHSTPTMESFTSDPSLLFRRSNPSAASLYASTLSPPTSRPMSPAGRGSPSRVLSGSVLDTLPGRVPQDSASSKPGEPLNLLLHSFVPHVAVYASEDTEALMREKGLRDGLWQLLRPFGEKVQGKVTVRDSNGISRTYDDFSVRFTKLGDNVGYPDPTVSGTGPSQASKSHNGDQESATRDRKILNDVEAVVELHLSYAEQQALPASSHRRYAAKAVQDLETASPYYSLYLRRLLSAFSITPHETFAHPVACIVAISSRNETPIEELRRLYTETKQGCSKLPPWVDSDYLRYYVLVHDEEKDDITRSMTLFEQMKRHLGLHCHLLRLRCSQSVETDDDSLPLPRSEWMSAAEELAQIHMSESMEEFEDPTRYMFESDATALRMFVREMVTQSIVPTMERHISIWNDQVASRRRGITGRLMTFSRKWTGLGGGSRSTSGGTGLSKDNYDTSGFYPADSPEAIIRRLADYAFMLRDWKLAYSTYDLLRSDFSEAKAWKYHAAANEMSAISLLLIPQSLTSKSRAETVNQMLESALYSYGTRCSAPYGALRSLTLGYELLRLRGGSNIDDAGRWGIRLLETKILGQIGDALLKERLAVCYASKGSVANLSLGGRHRKSAVWSILAADSWCHQAKYIPAQRCLEEAQRAYQLLPHKHGVSGFGSARSHVRALQQEVAEKLQLGAEDATGTAEDETEELIDEESEALTDTRARRISVGAGGTMFMFETAPLHGDEPEETVMTSPGASQAQEGFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L418</accession>
    <name>A0A367L418_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI08952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L418"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="40" mass="4314" checksum="3B4C59834E4DC6F3" modified="2018-11-07" version="1" fragment="single">YLQTVWPVEAVTQLPKKGGLAEADTEISAGIGRSRRTRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4H0</accession>
    <name>A0A367L4H0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glucose N-acetyltransferase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_1413</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4H0"/>
    <dbReference type="STRING" id="1330021.A0A367L4H0"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI09326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="354" mass="40942" checksum="DED320AF28B7B0E5" modified="2018-11-07" version="1">MATRLQHVFHLFRSSQDATRLCAILSSRWPRLAATAGLVILLLLVGRNYERARPETDGLVHNDVDWSRFAYTQYVTNSEYLCNSVMLFDILHRLGSKADRVIMYPSEMVSPSATDDGRLLIKARDDYRVRLVPIAIQHRHSADNTWADSFTKLLAFNQTQYSRVLSLDSDAVIMQTMDELFLLPPCPVAMPRAYWLYPEKKMLSSQLMLVQPSSSEFQRIMEKVNGAKGSDYDMEIVNDLYQDSAMILPHRPYDLLTAEFRTDNHVNYLGSDREAWDPVAAYNEAKFIHFSDWPVPKPWIAMPEHVRAEKQPKCRNKDGVEQCVERDFWNGFYDDFRKRREVSSSSVVDISLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4M3</accession>
    <name>A0A367L4M3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_3654</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000015">
        <property type="protein sequence ID" value="RCI09370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4M3"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI09370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="71" mass="7539" checksum="8937297DB07F09E0" modified="2018-11-07" version="1" fragment="single">AYTEADCIAKEGTPCLTYSKEGSLTYPTFLPSYGPYGPYSPAITYSLCDVRRPRAGCSRPASLSGAPAKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L537</accession>
    <name>A0A367L537_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nucleolar GTP-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_4065</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Involved in the biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Nucleus</location>
            <location evidence="2 7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L537"/>
    <dbReference type="STRING" id="1330021.A0A367L537"/>
    <dbReference type="OrthoDB" id="415015at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01897">
        <property type="entry name" value="NOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000496">
        <property type="entry name" value="Nucleolar GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024926">
        <property type="entry name" value="NOG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041623">
        <property type="entry name" value="NOG1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010674">
        <property type="entry name" value="NOG1_Rossman_fold_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012973">
        <property type="entry name" value="NOG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45759">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06858">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17835">
        <property type="entry name" value="NOG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08155">
        <property type="entry name" value="NOGCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038919">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="OBG-type G" evidence="10">
        <location>
            <begin position="168"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="542"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="452"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="596"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR038919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI09527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="655" mass="74590" checksum="6BC7DC53540FA528" modified="2018-11-07" version="1">MKTTWKDIQPVPSQKELLDIVLSRTQRKLPTQIRAGFKISRIRAFYTRKVKFTQETFSEKFGVILDNFPRLQDIHPFHKDLINTLYDADHFRIALGQLSTAKHLIETISRDYVRLLKYGQSLFQCKQLKRAALGRMATLVKRLKDPLLYLDQVRQHLGRLPSIDPNTRTLLICGYPNVGKSSFLRSITRADVDVQPYAFTTKSLFVGHFDYKYLRFQAIDTPGILDHPLEEMNTIEMQSITAIAHLRSAILYFMDLSEQCGYSVEAQMQLFKSIKPLFSNKLVFIVINKIDVTRLEEVDADVQAELQNLLKSGEVEMLQLSCNTQEGVQEVKKAACERLLADRVNQKLKAGTSASGAVGGRLADVMARIHVAQPLGGQTRETFIPEAVKASKKYDKNDPDRRKLARDVEAENGGAGVYNVDMRADHLLKNPEWKYDKVPEIFDGKNVYDFVDPDIEAKLQALEEEEEQLEQQGYYDSDDDIEDEDEAEILHKAELIREKQQLIRNEARMKKRLKNQAIIPRKSVKKPFSELEDALDQLGVDTTNLADTAQPKPRTRGRSLTRSRLGTADGDDAMDVDATTAKDRARSRSRLPASNRRVDGVQDPTLRSKAERLAKLHQKKMNRMARQGEADRHTPASMPKHLFAGKRGTGKTSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5B8</accession>
    <name>A0A367L5B8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_4147</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5B8"/>
    <dbReference type="STRING" id="1330021.A0A367L5B8"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF13">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016579011" description="FAD-binding PCMH-type domain-containing protein" evidence="5">
        <location>
            <begin position="20"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="85"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI09598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="543" mass="58868" checksum="0F52F047AAFD5F58" modified="2018-11-07" version="1">MHTSRWLLCFAAASASASASASASASTGPSLPLLSPEVETVCSVLQSRYPTQLIWNPISRRGSETAVQSFVHKEVLTGYLNSESVSQRPACVFLPSDAEQVSFAVRTLNSYPTVRFGLKSGGHNPNVGFSTAVGGLLMAFRPNLRSVKLGGPDVRSVLVGAGCKWKDVYEALQPLGKTVVGARADDVGVAGSVLGGGLSYLSAQYGLACDNVLSFECVLANGTIVTASPASHPDLYFALRGGGNRFAIVTRMMLRTVDVGQNGMIWGGIRFYASPESAALRSAVANFTANVADPKAAVFPFFGFVHLLGFNTHLSVVFFFYDGLDPGGVFDEFDRIHFVSGDVGRRTYESLHKELLGGEYYGSRVRFRMQSFPNLPPADTSAFLDQYFQTFKTLTATVSSSALDGTTMSGFSVESIPRSVAQRGGTNALSMDPREGDRLWIFSFIRWTSNDCDDRCPSKLKEVSDSMLELHKRHYAGIRPTNYAGDDGNSVGYNPIFMNQASHDQKVFQSYGDATYRRLKAIRQAYDAQGLFSNRQGGFHLAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5W7</accession>
    <name>A0A367L5W7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">4a-hydroxytetrahydrobiopterin dehydratase</fullName>
            <ecNumber evidence="3">4.2.1.96</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">4-alpha-hydroxy-tetrahydropterin dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_4174</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin = (6R)-L-erythro-6,7-dihydrobiopterin + H2O</text>
            <dbReference type="Rhea" id="RHEA:11920"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15642"/>
            <dbReference type="ChEBI" id="CHEBI:43120"/>
            <dbReference type="EC" id="4.2.1.96"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pterin-4-alpha-carbinolamine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.96" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5W7"/>
    <dbReference type="STRING" id="1330021.A0A367L5W7"/>
    <dbReference type="OrthoDB" id="277398at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008124">
        <property type="term" value="F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006729">
        <property type="term" value="P:tetrahydrobiopterin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00488">
        <property type="entry name" value="PCD_DCoH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.20">
        <property type="entry name" value="Transcriptional coactivator/pterin dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00434">
        <property type="entry name" value="Pterin_4_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036428">
        <property type="entry name" value="PCD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001533">
        <property type="entry name" value="Pterin_deHydtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599">
        <property type="entry name" value="PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12599:SF0">
        <property type="entry name" value="PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01329">
        <property type="entry name" value="Pterin_4a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55248">
        <property type="entry name" value="PCD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI09820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="171" mass="18685" checksum="4FB9648F4B6A8153" modified="2018-11-07" version="1">MPAPAAGAAVAASSAARRRLLASASLPLRRRRLSSSAAMQPRFAPGTNTHSLEPALASLLGRWQLASDGRALERTFRFKTFAKTWDFMTAVALQAKIHNHHPEWSNVYNTTLVRWTTHNPLGLSEKDVRLAAICDTLAGDFQEVDVKESAGDTVEEELLARVVTNARDCCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L643</accession>
    <name>A0A367L643_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_8420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI09891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L643"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI09891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="328" mass="36902" checksum="C41BCA6517B49FCD" modified="2018-11-07" version="1">MEQREKKKTKEEKKKKEEKEKKEKKKEKKEKEKKKKKKKKKKKGWRNPTSPPPPFELTSSIHPARRISPVNHNPTSGPPVRMTRSKRRHLTGIEQVMQSHSKVGNGKNSTSIVLTMFLPSLTLALAAVAAAWSLPFSERSRPGDCQKFHFAQKGISQAACRSSDNLKSCLACQDLYLELGCLDVDFTSFPTCQREIGTNCTACADHFAEPIGSSIPKKPQQEDGQKVGACKGFPLNGSGRLQVECRRDDERCNRCESSYSALNCDRFRLPLASCTREFGEDLRACDEYASTFSGPFSEIKGRGSERKGFASSFQIDEDATLLHRYCSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6A8</accession>
    <name>A0A367L6A8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI09965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6A8"/>
    <dbReference type="STRING" id="1330021.A0A367L6A8"/>
    <dbReference type="OrthoDB" id="4708870at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35711:SF1">
        <property type="entry name" value="ECTODERMAL, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35711">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="473" mass="53635" checksum="87AEA759606CEE0A" modified="2018-11-07" version="1">MGGSAFSSGTDPLFTPRMPPPIYDKMRKHCTALLSHLFRTVASPIDGPGKSDYGDVDMMVAGPLATETTLQDVAKALGARRSNLYGSRSANFALEWPCSEFSAAEAEQEEEEGEEKEKEKKEKEKEKEKEKEKEKETKEEEKDRYVQVDVFVCPDDEALSWLLFMHAHGDLGSILGSIVKRYGLTLTEQGLFIRIPEMEASRPKQARVFITRDPNTALRILGLPAERFWSGPFADADDMFEFASLCPMYSVGDDDDDDDDDDDDDDDDDKDHNKRHRLRSSDKRRLRSRPVFRRWSVDFRSRCRRQGLFLQPRTSRESTTESIMASLPSVQAAYANRRLGFLREQQESKIRNELIPSLASSSAAKQEDTRPHMVAAHRACLSKSLARLVLSGDESFVGVVERPDDGFVDAESGLYDLGRVEAFVEENCEAVAAVAMERHWAAMRARMASRQRRREEEEKEEEEEEEGVVVVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6I3</accession>
    <name>A0A367L6I3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">26S proteasome complex subunit SEM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_8747</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the DSS1/SEM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6I3"/>
    <dbReference type="STRING" id="1330021.A0A367L6I3"/>
    <dbReference type="OrthoDB" id="5586203at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd13768">
        <property type="entry name" value="DSS1_Sem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007834">
        <property type="entry name" value="DSS1_SEM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771">
        <property type="entry name" value="26 PROTEASOME COMPLEX SUBUNIT DSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16771:SF0">
        <property type="entry name" value="26S PROTEASOME COMPLEX SUBUNIT SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05160">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01385">
        <property type="entry name" value="DSS1_SEM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="32"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU369057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI10037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="93" mass="10474" checksum="BDD8DC40B386D988" modified="2018-11-07" version="1">MASDDKKLAAAPEDKPADQQKAQAESKTAVLGEDDEFEDFPSDDWPEDQTEAAQGNSEAKHLWEESWDDDDTSDDFSAQLREELKKVEASKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6K0</accession>
    <name>A0A367L6K0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_8509</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF187">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="9"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="273"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="482"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="12">
        <location>
            <begin position="12"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="512"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="580"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="515"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="586"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="1443"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI10051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1501" mass="163684" checksum="55A9D0D5BC00897E" modified="2018-11-07" version="1">MDNSNKGRFWLVFTAISLTTFLAALDTSILSTALPTIANSLGSSELYLWISNAYLVSSTATIPLFAQAANIYGRRNLTLLAVCLFALGSGLCGGALSTHLIIAGRAVQGVGGGGILTMSEIVVCDTVSVRERGLYAGVLGAIWAVASVVAPILGGAFAEGSASWRWIFYLNLPISAVALLLLVFFLHLRRPPSGSVREQLTRVDWGGFALLVPSVAAVVVALGWGGSRYGWSSWRVVVPLASGLAGLVSFFAYQASPWLREPTMPLRIFTKRASALCLAISFLHSMLLFWACYFLPVYFQAVLEASPRRSAVMLFPIATTSAPAGVLAGVLITRTGRYRVWHLLGLGLTAVGCGLCSLLDASASTGTWVGFQLLLGFGFGFVFTSTLPPILASLAEADVATATGAWTFLRNFGSVWGIAVPGAVFNTVTSRGASVVSDARVRGLLAEGGAYEHGTRSFMLSLDASPSLKAEVIQVYVDGLRIVWRASIAFAVLAFGLALFVPALELREELKTEYGLEEGEGEGEEEEEEEEEEEEEEEEEEKKEKKKKDKSWVDVTLSERGVGEVENMNWTEFHNIIAGKPRAARTTGPGTTSPHTGKPLWPVPVATASDVDDCVAAAKEAQPSWSRQTYESRVLLLDAFAELYLDHAAALSKLLAEESGRTVENAAVEVSWAAQWLRYPSSFLLPQERLEDESKVVLVRHEPLGVVAAICPWNFPIMLAIGKIAPALATGPTLVRHPGVDNISFTGSSATGKEILKAGADQMKRITLETAGNNAAVILPDVDLESVCPRIAAGLWFNAGQVCIAPRRLYIHHGIFDGFVERLASATADLTRHLPSRIGPVQNHPQLRRLLRALDAAAADHDFVSGGPAEKADGLFLQPSICVKPPADSRLLREENFGPIVCCVPFESLDEAVRLANDVESGLAASVWAADADAAAAVASRLEAGSVFVNGPCRPDPCVPFGGHKQSGLGVEYGLEGLLSYCQTKAIYILDCGRALFSFFSSHPWSLSLMASNSSPTMIVTSIILILTLVLVPKLIALLQHALSPLFSIPGPLLNKLSSWPLTMATLRGTSHHFARQLHKRHGPIVVMAPGIISVADADEIRRIIRTEDWPKSEAIYGNFRQDPSRPTLLAYTDKKAYGRRKRLMSTMFGLRSIRAMEPLMRQCVAVAEQRLTRACGEDGSVVDMLQLIHGLAIDIIGITTFGRSLGVVEKGSHPLPTRLKKGLKIAAWMQLMPWIRRLPLLPTRDPYIDRFTRETVDGRRRLRSPEPASDLLQGLVEASDDGPESEFRTSDVQDETVVLLTAGSETTANAELFTLLLLSRHPDVLQRLYAEVDAWYPPDEEPPREADCGYSQAGMVYLQCCIDEAMRLVPGQATGSAREAVGDETTVLGFRLPRGTTVFPSTQEAHLDGRFWDQPDRFDPERWLRHDRCRPFWPFSAGSRVCIGKHFALQEMHLTLVSLLRRFRFEHVPGQDEETVFRVAQQLAVDSYWMRVRPRKPAME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6X5</accession>
    <name>A0A367L6X5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6X5"/>
    <dbReference type="OrthoDB" id="4926095at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016694235" description="Hydrophobin" evidence="1">
        <location>
            <begin position="16"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="15478" checksum="3504A986ACDBE466" modified="2018-11-07" version="1">MYALQLIVLAAAAMAVPMPGNYGGDNNNNNDYGMKDYGHKDYDNEAGKGNGYGKDYGHSDYARGYGGGDDDEHRGWRPTNSRGKTFGDQCGSNANAHCCEAGGDESSACRKVSSLDLLVQGNCQGQVCCSGPQSGLVNIGCIPIKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7H3</accession>
    <name>A0A367L7H3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_4251</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7H3"/>
    <dbReference type="STRING" id="1330021.A0A367L7H3"/>
    <dbReference type="OrthoDB" id="409928at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI10378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="184" mass="19903" checksum="3ECFB935B7A6159C" modified="2018-11-07" version="1">MKLINNATNIDTTWYSQQYDSAFTPLHRYFEDVNSARLAITSVSNTKYNLLLALAMHRSGLFSGVCRSPASSPPSLEDMVSKPPQVVTQSNVARMRIWLGLKYLDGEPVFSKATLVTKPGRVVSTGIHKLGDLAQGFDSELSRGGTVGGLNVGELLFLGTACGILEVREALSRKVGGILLCRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7P9</accession>
    <name>A0A367L7P9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_4272</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7P9"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI10441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="103" mass="10972" checksum="1DE8C142B58E194F" modified="2018-11-07" version="1">MWGKSGAVEEEEGVEIIMSNRGVDYVIEKKKTNHVIVGKPPSFIDKFLNNKVRLSRSGAMTAISTARRSLAPIDVTAALYSAPIAVTIAVTSRSGAITAIALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7T4</accession>
    <name>A0A367L7T4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_4471</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7T4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI10479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="74" mass="8138" checksum="EA42316E3DC5D2F6" modified="2018-11-07" version="1" fragment="single">ILTRRLINPYIQKIRLPWLTSLPRLPDLPYVPSFPPPTLLCCSYLSSVTYGGLGPAIAGPALPASYIVMPFLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L892</accession>
    <name>A0A367L892_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Rho-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_4423</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L892"/>
    <dbReference type="STRING" id="1330021.A0A367L892"/>
    <dbReference type="OrthoDB" id="79452at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09394">
        <property type="entry name" value="LIM1_Rga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09395">
        <property type="entry name" value="LIM2_Rga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.555.10:FF:000043">
        <property type="entry name" value="Rho GTPase activator Rga"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.10">
        <property type="entry name" value="Cysteine Rich Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050729">
        <property type="entry name" value="Rho-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001781">
        <property type="entry name" value="Znf_LIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176:SF128">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN RGD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23176">
        <property type="entry name" value="RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00412">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00132">
        <property type="entry name" value="LIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50023">
        <property type="entry name" value="LIM_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-0440">LIM domain</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="LIM zinc-binding" evidence="6">
        <location>
            <begin position="40"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Rho-GAP" evidence="7">
        <location>
            <begin position="1019"/>
            <end position="1206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="181"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="603"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="930"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="280"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="318"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="352"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="401"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="466"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="489"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="544"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="623"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="652"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="930"/>
            <end position="945"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI10639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1209" mass="133054" checksum="15CE44226DC3736A" modified="2018-11-07" version="1">MLSPPPTSSLAKSRVFPLAVVMATIVDEYLDSPMDNDDVFPCKGCGEILEEGKAFELGEPTSSCCFADGFIIPPPLSTAGNRWHLDCFRCNTCGTLLDSDANLLLLGDGSLICNNCTYSCSACGNKIEDLAILTGDQAFCATCFRCRNCKRKIENLRYARTSQGIFCMGCHETLMARRRKKTKAAAKSREKDLSPMGVEKSLPALPPSAVPPSAFSKDRSVEPDSDTPTETSPLPRSAHRHNESSSRGSSRPARSPEPESTLSLPPSNYRKNRNSTILQSAESVSSDSPESFFVPVALDPSPGPQAGSRSTSDGTSDAVRRKKDDYFSIHRSTSSVDKHSNESQSSTPHIAFQDKGRQTSSDHDGASSKAPSRNVSSRASEQGVNRSSAPGSDFRPHDAPSSINDVSSRSNSTSSAPLESCANKNSNGAPRGDGPPNLSELRRAKENSPPPRMSQDSRWQDDDETSSSVDVGSSRVQKTKAMIRKEMPSASARASRTVASRRRRSASGGRMGAQGRASTEQKGAGDTYMHPRAAPVPPGGQAQADHESQSFKDEPSSPKVSPKLPRWSSGGDFSMDEDMARILGTDESSSSILRRVSNVVRHGRNNSVEAGQHTHRIHHARSISETTRATTSPRWPKSPMADEHNGLGDISSPVSLTSSDDPSLLRRQLRNSEQRVAELERQFNTEKDLMNLNKRLIEKRKTVSVLDTQTEIMIRQLEVLAGYVERAKETKTPIDPRVLEDSAIKEFVQKLEKVKIVMSASIEQLHEERDQLVEDKNRAAADRDRALMEFEQLSSKNAQLADMNNDLTHQIQERFKSQIGTDAKAPNGLGIYGQRQAASSLNLDSSSVTTGATLVPDEGDHIVEAGPTVVQVRKGQVKKFNWKKGSKTVAQNVAKGVNRAVVAFQQNDRERAHGLAGDNIGLPYNMTVTQADSPASMGPNSSSLALRQHQHPMSQHQHQHQQQHQHQQYPPQQQPHHHLDPGRQGFGFFGKKSAMTKSTSASAVSVATPAEPPSTLFGSELADRADYERRQIPTVVTRCIEEVELRGMDQEGIYRKTGGNSQVNMIKDGFDKSDNFDISDPDLDITAITSVLKQYFRRLPTPLLTFEVYERVLESNAVVDETERCDHLRRTFASMPQRHRDCLEFLVFHLSRVAQREPENLMSPKNLAVVFAPTIMRDLSIEREMTDMHAKNIAVQFVIENSHRIFDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8G5</accession>
    <name>A0A367L8G5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8G5"/>
    <dbReference type="STRING" id="1330021.A0A367L8G5"/>
    <dbReference type="OrthoDB" id="4586300at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="350" mass="38720" checksum="8137A2A6E420613E" modified="2018-11-07" version="1">MQIFDSLAPKVTPRHTHIAPHRATSRHNTNHNLFLPSTTTTHPVLAPQIYSSTWKKTMDSPFTSNNPLFSILASPSYSPFFLNYLPQPIPKDLPPSLDSSVYTFADAFEDLLLVSQGHALPKIDKRHETTSFLRRLFPAGEPEEVYVRRLKSELQVQQQPSPDWKAFHRQLDSRATEVWRRPSSSSSSSSSSSSFSSSSSSSSSSSSSPSSPPSEAQDDDKQSRRPPPNTFNDLFDSLSSAFAEGQKSWDTLLDIVTDRFRPSHPEHAPRSAVAQADKAWDALVKIMAGENASAQSHDEESPGYHKKTTVQPILDENGFQIGEATTTVISTSSKHSDASDQVHKVFTACH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8N1</accession>
    <name>A0A367L8N1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_5283</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8N1"/>
    <dbReference type="STRING" id="1330021.A0A367L8N1"/>
    <dbReference type="OrthoDB" id="2117459at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047168">
        <property type="entry name" value="LEC1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024554">
        <property type="entry name" value="LEC1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024555">
        <property type="entry name" value="PX-associated"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47185:SF2">
        <property type="entry name" value="FUNGAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47185">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN YPR097W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12825">
        <property type="entry name" value="DUF3818"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12828">
        <property type="entry name" value="PXB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX-associated" evidence="3">
        <location>
            <begin position="2"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="161"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="369"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="575"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI10783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="638" mass="70256" checksum="7DFF52DEB7D4478C" modified="2018-11-07" version="1">MTLTAEQRRALLDVLTHHQTYSEIQAFQRPEAVINYGSPFEARDDGSSGSPILQMLLTRFVLPLPGMRRLPASFWRVQVQGLLGRLAEAELSESYDRGALGARKTLATGSSALLEMVARGCLGGLERGDDDDDDDDDDEGKRLAKAWHEVLQGLVYGDMVDELFDHVSQTDDIECYSPVVASAIDYIIIHLAGFAHSVFIRSAEGQYLLKLVSQVHGMVPYKLVKQTMRVGNAATMMSGMSRLLLAKLSVASVTNWFGLTQKADDGMNLVQRIVSLVLSWDAADFRKSAERVERAAREEEDGPSEEVLSALRRHVSAGRQVHDEVRRRSRESSRSIVAEILVGCPQATELTEAQHAQCLDFYSALWSIRDRDAMTAALCRTPPDLFTQAIKDVMAAYEGLIRSVHSRVDLREHVDATQGFVDDFLRASKPGEGGEAPAVADYVRLLRRNRRLLYRWLHVLARHCPDVREDLRTWCKESVVRFRKPMEQDHLASGLDDLVNSIDDENTRRRVVDAIDRHASYLKSLSAQSQARLSALASSSSSSSSSSSSSSSRESSKAAAPGSYLSRWQSLLDSTPVTPTSAARASPARTGREVKHLTAKGKTGLCVGGGEAVVVDEVEPPDVGPVVEKTLILIRSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8S9</accession>
    <name>A0A367L8S9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_5247</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8S9"/>
    <dbReference type="STRING" id="1330021.A0A367L8S9"/>
    <dbReference type="OrthoDB" id="165352at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.20">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045861">
        <property type="entry name" value="CorA_cytoplasmic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494:SF1">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143865">
        <property type="entry name" value="CorA soluble domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="469"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="190"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI10833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="498" mass="55455" checksum="561B8B5EBCDD1672" modified="2018-11-07" version="1">MFRSIQHSGDILLQRHQDFDPQPGAEPGFDPDLPDGGHASMPSLSVPCEITVIDFSAERMVKRHFDNQAFIAFLQRPKDDWACCRWINVNGLSWDVLQAVGSQKGLHQLALEDVMNLRNRTKADWCVFSFFHYLFGEADDADDADDADDADDDDDDDDDDDDDESRYPNHAYIVLTLLKLVVHQKNDVQTSSASPSSLFNFLRRPPTQADAPESEKGRRPSPTTLLPPPRSLHRFHASANEARTAMMERESLLAPRNMAVSAEQVSIFLTSDNTAVSFFEASAADVERPMVTRLATAGTILRASCDASLLVQALLDAIVDLALPLTTVYSDLLGDLELDVLTAPSISQSRSLYLCIAEINKMLRFLQPVDGLVNALRHHRSPDDGVVVSSVTRTYLADVLDHCIVICDALQQLKQSSEDLIGLIFNTISATQNESMRQLTTVTIIFLPLTFITGFFGQNFTDFPELHRGIWYFWACAVPTAVATVLILMHDMIYSCRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L912</accession>
    <name>A0A367L912_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L912"/>
    <dbReference type="STRING" id="1330021.A0A367L912"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="57" mass="6068" checksum="690807BB15D7A2F1" modified="2018-11-07" version="1">MFTQPLSSPPPGPPPAAATTTTTAATPVSSAARSSRLRGFSYLRNYTHNHLLSRDVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L920</accession>
    <name>A0A367L920_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5393</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L920"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="100" mass="11317" checksum="AA1500A6E26E1D9F" modified="2018-11-07" version="1" fragment="single">PLLSFSFGIAPSAAPPDRAPGDTVGVPIIQYGRSFRSAPPLLLRRTRPPFLLLLPVQSRNPSNRLYRRFCNPMRPGRNRPRPPYSLPPLPHYPRDYLSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9D0</accession>
    <name>A0A367L9D0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">L249_5188</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI11033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9D0"/>
    <dbReference type="STRING" id="1330021.A0A367L9D0"/>
    <dbReference type="OrthoDB" id="2496787at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF143">
        <property type="entry name" value="EXTRACELLULAR MEMBRANE PROTEIN CFEM DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="14" id="KW-0349">Heme</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016917507" description="CFEM domain-containing protein" evidence="16">
        <location>
            <begin position="19"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="165"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="203"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="17">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="14">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="24"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="38"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="47"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RCI11033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="421" mass="47070" checksum="E17F83C6BFEC9D01" modified="2018-11-07" version="1">MRPRSLLLSLAAVLTVVAQELPGCARTCLAPAVKESKCLPTDQPCLCTDHVLVKNVTACIMVKCTIKEALLAKNVTATACGEPVRDKSPGFVAVSDAFGILSSLCVIQRFAFKYWTKLDFGLDDWATLAAMVISIPSIAINALVVGPNGMGRDTWTLTYENITTFSRFFFILEILYFADVAMIKMALIFFYVRIFPAREVRRLLRGTLAFVALFGLVFTAIAIFQCVPINYYWWRWDGEHSGRCLDMNAITWSNAAVSIAVDAWMLAIPLWQLKSLKLDWKKKVGVAMMFCVGTFVTVVSILRLRALDFSSHSANPTWDLFDVGIWSTVEINVGIICVCMPSLRLLLVRLFPSLSTSSSQRGYIRSDPPSRRRVVDNKIVQQMTYSVEYGDKEDADDRTHVVYLRDVDVRTLPARGGENVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LA21</accession>
    <name>A0A367LA21_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial inner membrane protease subunit</fullName>
            <ecNumber evidence="8">3.4.21.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_7769</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase S26 family. IMP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.-" evidence="8"/>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LA21"/>
    <dbReference type="STRING" id="1330021.A0A367LA21"/>
    <dbReference type="OrthoDB" id="308440at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052064">
        <property type="entry name" value="Mito_IMP1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019757">
        <property type="entry name" value="Pept_S26A_signal_pept_1_Lys-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02227">
        <property type="entry name" value="sigpep_I_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383:SF16">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383">
        <property type="entry name" value="PROTEASE FAMILY S26 MITOCHONDRIAL INNER MEMBRANE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00760">
        <property type="entry name" value="SPASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016703155" description="Mitochondrial inner membrane protease subunit" evidence="9">
        <location>
            <begin position="23"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S26" evidence="10">
        <location>
            <begin position="17"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S26" evidence="10">
        <location>
            <begin position="109"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="40"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI11265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="174" mass="19116" checksum="69E5CFF7D5556E2F" modified="2018-11-07" version="1">MFQHLLGHPFRLAIGTVKLVCASHLVFTHVLELSACEGYSMLPTFAANGEWLLFDKTARRGRRVAVGDIVSYKLPFDPRNLGVKRVIGMPGDYVSLAAPGDPGDGHVLQVPKGHCWVVGDNLTLSRDSRMFGPLPLALIEGKAVASVLPWKNRRWIENGLRPPEESIALPSQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LA43</accession>
    <name>A0A367LA43_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7205</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LA43"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="158" mass="17050" checksum="D315B7CBC812B311" modified="2018-11-07" version="1">MGIADDEKMGRKSVVSICNDITDGSRLYRTNARFQLLVPIHEASLHQLSCHRASHGIRISRSPKLKQAASGRGQGGKQTQDKMFVRSSLAGLTPCDLQKQSPGPGQSFFSLPQKPRQIDRYAMTASLSASAGRELLPGSSQHGTPSPNPRLSMGKSAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAI3</accession>
    <name>A0A367LAI3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7525</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAI3"/>
    <dbReference type="OrthoDB" id="5285218at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="112" mass="12554" checksum="A3E7A4196A2FD072" modified="2018-11-07" version="1">MGQSLLTRIQAKLELFRLEQRYTRHRHRRSTFVSNAVYVDGEYVFQTPVTTGSSAGCSTTRVDALHADPSATGKTSQSAAPERKRLSRFSSMTAFGTKDKIQIVERRSSVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAV9</accession>
    <name>A0A367LAV9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7905 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_7349</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAV9"/>
    <dbReference type="STRING" id="1330021.A0A367LAV9"/>
    <dbReference type="OrthoDB" id="4739136at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057227">
        <property type="entry name" value="DUF7905"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25482">
        <property type="entry name" value="DUF7905"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7905" evidence="2">
        <location>
            <begin position="207"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI11553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="525" mass="59824" checksum="0BC13372946A8794" modified="2018-11-07" version="1">MRRQPRAGRPPANRQWSQGQGQTSERGNNFYRSSSSQGNAPENSRQKWKLGTKMATAKSQMDAKRQTAQMAAQEEYLKPPPENLVDSLIEASLVIPGKHMLPRGLDSIASFDDICQRNKVWIKLSDRNIIEVRADNIKRLQNAMREINWLIHDMRLSSENLITRFLVQKPVNPNLEHDTGISVKLNSRPTSTMNSPSLVSVAPPLAYDNFTKLRGILEMSAHILKALRTGLRMRVNFGRFEIRQRKRGVGDTMTYPCFEEMVALYSKRGGAGMHTELLDVANAEKVVQHLLKPVVGIFDHGKRPLQMQHTIILKFQNRELISVVQGQPEQPTQVSAARMRSREILPRLNWTVAAPDMQLDWNLQVDRCEPMHNVPDMLRKVMDNISLTERGRDDDSSLLQPPRVEIKPQPGSEEIESTVVKTSVILPFRTTKFVIEVSITQSWNRMTTNSEPDTCWGVEMYGLHWEETLEGISSREQRDDWNAVMRSLWPSESQDLDAGFLCFLEHVVEVQSALSALELDSTVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAY6</accession>
    <name>A0A367LAY6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TRUD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_7160</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase TruD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAY6"/>
    <dbReference type="STRING" id="1330021.A0A367LAY6"/>
    <dbReference type="OrthoDB" id="447290at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02576">
        <property type="entry name" value="PseudoU_synth_ScPUS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.20">
        <property type="entry name" value="TruD, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001656">
        <property type="entry name" value="PsdUridine_synth_TruD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011760">
        <property type="entry name" value="PsdUridine_synth_TruD_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042214">
        <property type="entry name" value="TruD_catalytic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326:SF21">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE PUS7L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01142">
        <property type="entry name" value="TruD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037016">
        <property type="entry name" value="Pseudouridin_synth_euk_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50984">
        <property type="entry name" value="TRUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRUD" evidence="4">
        <location>
            <begin position="337"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="507"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="633"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="508"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="521"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="652"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="698"/>
            <end position="710"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI11581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="755" mass="83444" checksum="3221AEA73EFFF956" modified="2018-11-07" version="1">MTQVPGHVMRGGASHSRSIGITNRATPLTLAWTGDQRARYSDFQVNEIAQDGHVVHLLQVGLSDEQKRKQGAQQALDQTADTDGKPPVGIEAAKDLSTEVAAEDVSLLSTLGGQIFADDVVRLSKGGDDATDQVKSEAISDKFKRGRIHGEIRRIFKSAIETSTEDSGAIIAYRASSRKGKRRNRGARGQGRDKPSGEYLHFTLYKDNRDTLDAVNQIARMLRVKPQLIGYAGTKDKRASTTQRCSLRHANQRALAGANGKLWGMATGDYDYRNEPIHLGDLLGNEFVITIKSCRLVVVDNDKNSVDDAQTPLSTEKLKALLQEHAQSALDHMATHGWINYYGHQRFGTHRIGTHEVGKLILGEKWEDAVNALLYYDEEVAPGSTAPNDDDTSSQQQQQQQQRREDYARHRACMLFRTGADIEEAARLMPPRFAAETCLLRHLTRQGKASAKDYGGALTHITRGLRSMYLHAYQSYVWNHAASRRWELFGSSVVEGDLVLIDEALNKEDEEEDQDNDDLLLDPTTASTSSTTTTTTTVTARPLTAEEALSNRYSIQDVVLPSPGYAVTYPSNALGTFYQDFMARDGLDPHKMRRLRREFSLPGHYRKLVCRFLAPPAVHFRLYHDDAEQMHPTDVHLAPRPPKRVATAADADAADDDDDDDDDNDRDKKRRKLDADPATTKLVAAATDPDHDTASNRAMADAKAATDPAPQSDNPSKIAAILRMQLAKSAYATVAVRELMGDLPETVPTVDVVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LB04</accession>
    <name>A0A367LB04_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7418</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LB04"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI11595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="148" mass="16415" checksum="523E199791FFCC32" modified="2018-11-07" version="1">MGVLQVGTLKYLEKIISISFSHLLNTNTSPASNSSSIASFRLLLEIIMSNQGVDHVIEKKKTNHVMVVFNKVEADNKLEVGTSKVRPSRSGAMTAISTARRSLAPIDVQRADRCDDRCNESIGRYDRYSPTVTQGVVAGLRPNWYNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LB46</accession>
    <name>A0A367LB46_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LB46"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="217" mass="24949" checksum="3733287EBA51C158" modified="2018-11-07" version="1">MEDEQEENVFWYWIREALGFTRNHEEQKKDSDAKLALYTTTLSLEKGKRGRRRLHEQLLSSKEQTKRPKMKHHRLVRDSDTSRRQPCLMLCSIDRTIHDIKHTTCLGSSLDVYARFVLALMSMPGCMECNALQGSSIITLYGFIEKASPPGPWCLSDRPNCMLKLPSIHLFLPPGRASSFLMPSCHDRRMLKQAASLVKHGDDPEQHEQTSNPQANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LB64</accession>
    <name>A0A367LB64_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7213</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LB64"/>
    <dbReference type="OrthoDB" id="5405126at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI11655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="426" mass="48610" checksum="B3FEBD24A9023733" modified="2018-11-07" version="1">MFRPMRFAASRVAFLPRLSTCPRRQFGSTSPACAIRAVFSQTDNEELNAILKKIQETIIFPAYLPAKQRKLIFDARARDELEMNPVIIEIEDQKYRFPPLDRSKDVPKVSTAFLDAVYKMQTPRDWENLPTLLAGYLKAQIQLRSSVYGKMCRVAARTGNIQAIIECAKQSKETGFAFRTWELIHRTFVANNARIYENSGDRRKMMQAYSQVVVLLDLLHRPEHTVVESNSRSRPQFSPLVRGMHLYALCSAIKAKQLDGKDAEKDMDHLREELKQFTPLWNEAAISDISSIPEVQSSCPSEDTKRSTQIGVNGYTYLQLMLQVARGCEMAVELVGDDARYLNRVRDAIIAHVAEFVRSAWGRDETWDDLYEKIMGQRPVWPAFEHREDLKHSYHKKLARKRAAVASDGASPPAWEMNQGGVDAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LC41</accession>
    <name>A0A367LC41_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_7746</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LC41"/>
    <dbReference type="STRING" id="1330021.A0A367LC41"/>
    <dbReference type="OrthoDB" id="4915767at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="86"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI11802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="218" mass="23359" checksum="80701E06B8F452A2" modified="2018-11-07" version="1">MPLPPRTIYSKRDTESHALQESFASAVMHGNATAVKHLLQNPKVDPGLPNRRDETPLFRAVMNDDKTVAKLLLDTGKAVPNRLDGSGWTPLAYAAMMGRAELAGLLLATSGVEPDAKDGTGWTPLLHAAAGGYETIVQQLLLLASAAGDGGNRVEVDGQDGQGRTPLWWAVENRHVAVVRLLVGSHRVKATSQDVYGLSPLEIAKRRGDKEMIGLLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCL9</accession>
    <name>A0A367LCL9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal RNA-processing protein 7 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_0968</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRP7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCL9"/>
    <dbReference type="STRING" id="1330021.A0A367LCL9"/>
    <dbReference type="OrthoDB" id="5390at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12293">
        <property type="entry name" value="dRRM_Rrp7p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12950">
        <property type="entry name" value="RRP7_Rrp7p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040447">
        <property type="entry name" value="RRM_Rrp7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040446">
        <property type="entry name" value="RRP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024326">
        <property type="entry name" value="RRP7_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13191">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13191:SF0">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 7 HOMOLOG A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17799">
        <property type="entry name" value="RRM_Rrp7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12923">
        <property type="entry name" value="RRP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rrp7 RRM-like N-terminal" evidence="4">
        <location>
            <begin position="11"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA-processing protein 7 C-terminal" evidence="3">
        <location>
            <begin position="192"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="240"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI12157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="35283" checksum="51E56B341EF86C60" modified="2018-11-07" version="1">MASADETSEEYAILPIRMPPLPSYPKASIHQIRVRRNAPKTPTPDDSRSLFLKNVPVDSTEPHFRAVFTSLVGAGRFESIAFDDDATAAPTADPCQAAKVAGFARKRKRAGSEDDKSQQDEASQLPKIWTRRLHRSSSTAIVLLVDDKSVRMVLKAIAKLEKTQKYPVWGESLAGDVPCLGMPWIAAHLQLCRCDKAVTQRAVHAFFNDFNRKEKEAAELAKKLRNEPDEDGFITVTRGGRAAPANRNEADNAKQRSMQKETQRKSETQGFYRFQLRERRKEEQLALLKRFEEDKRTVAAMREKKGKFKPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCQ9</accession>
    <name>A0A367LCQ9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_0900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCQ9"/>
    <dbReference type="STRING" id="1330021.A0A367LCQ9"/>
    <dbReference type="OrthoDB" id="10249920at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080042">
        <property type="term" value="F:ADP-glucose pyrophosphohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080041">
        <property type="term" value="F:ADP-ribose pyrophosphohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006753">
        <property type="term" value="P:nucleoside phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019693">
        <property type="term" value="P:ribose phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03424">
        <property type="entry name" value="NUDIX_ADPRase_Nudt5_UGPPase_Nudt14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839:SF18">
        <property type="entry name" value="NUDIX HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11839">
        <property type="entry name" value="UDP/ADP-SUGAR PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="3">
        <location>
            <begin position="112"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI12197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="288" mass="31478" checksum="73937E7F3FD93C06" modified="2018-11-07" version="1">MARSLSHRLLARYAHGSKMASDGVRIDLPEGLTQGQLQSFRPFKNWMTTLNKSLERQKAASHPFHADPYALRSVTVQSFDRFGGDRLGFVKLAATVSNSAGESLPGAALLRGPSVAVLVMLIPDDDSSGDERYVVMTMQPRIPVGSMAFAELPAGMVDDAGSLKGAAAKEMEEELGITIKDDELTCLSDMAADDGGEEKFDDDEGLAAAMYPSAGGCDEHVTLYSLERRIPRQQLRDWTGRLTGLRDEGERITLKLVPMKKLWREGARDAKALGALALWEALRREGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LD37</accession>
    <name>A0A367LD37_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_0473</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LD37"/>
    <dbReference type="STRING" id="1330021.A0A367LD37"/>
    <dbReference type="OrthoDB" id="6017at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000083">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037382">
        <property type="entry name" value="Rsc/polybromo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054551">
        <property type="entry name" value="RSC4_Ig-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062:SF19">
        <property type="entry name" value="PROTEIN POLYBROMO-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16062">
        <property type="entry name" value="SWI/SNF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22994">
        <property type="entry name" value="RSC4_Ig_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="55"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="228"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="128"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="352"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="136"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="184"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="380"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="417"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="459"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI12348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="640" mass="72080" checksum="3CD3487626D6B93B" modified="2018-11-07" version="1">MDSKRKAIAPAESDDRSSKRRKLTDFDLSKGESRESTTAYGLNFLDQIRRTTDKSGRPVATYFEKLLPRRENVDYYKQTRMPISLETIEEKLNNGEFQTLAELESYFKRMISNAKEFYPRSRSSTIYDDAERAAEEDQADDGAEDGDEDYRTGSKSLTELKGASRSSRRSIVLKRRESGRLSRKSTAQKVQRQSATPNRPDHQYKGVAYRGLSFQQAQEKLMEELIRYNEPEYDAYFEPFFYLPPRSLKDYYRVVTDPASLKKIQRMVRGTHSRYDTAGVSEFKTWAAFEEKCKLLWNNAYFYNEEGSEIFELAQELEASRLHSIPDNFGQEAFYGQLKKAQTFVPEPSQPKIKLKVGQPQEAPAPSKKITIHVGGRGGSTDSPAPNAPQSTAPPALNGSSATRSSVRLEAARGVSLSATPPLQPNHQAENGARMPTMVPVPFPAAGPAVARPTGPVLLPHPPPPPPPPQPLPPVDSRAMMANGHVEPRRFRRAGKGINDALIGRLRIQLHPNIMQAEGNSNGNPNLLTIMPHPTELLQSSAVTLSPHHNRVFIVLKIPEHLFHRQYSVWVLIDKQCLKPCIHPLPNQLPLERAFEAFLRPGMNVIETHFIAALPRNERRPGEPDVELEIFTAFVNLLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LD78</accession>
    <name>A0A367LD78_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LD78"/>
    <dbReference type="STRING" id="1330021.A0A367LD78"/>
    <dbReference type="OrthoDB" id="4157259at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="136" mass="14377" checksum="19454063B179C68F" modified="2018-11-07" version="1">MASVITIPAGRPTAYHDSSKAAGGSSASSYSSSSSPSSPSSTPGGTAMHTRRRSLLSSAISKQQCTVINIGDPDGPPRLVGMTPISYLSSSQGFAWNPEIFLPSYVDCDYEPLENQCEPVHEIVLSDEESKDLLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LD92</accession>
    <name>A0A367LD92_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_0155</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LD92"/>
    <dbReference type="STRING" id="1330021.A0A367LD92"/>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20612">
        <property type="entry name" value="CYP_LDS-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09817">
        <property type="entry name" value="linoleate_diol_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050783">
        <property type="entry name" value="Oxylipin_biosynth_metab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034812">
        <property type="entry name" value="Ppo-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903:SF13">
        <property type="entry name" value="LINOLEATE 10R-LIPOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903">
        <property type="entry name" value="PROSTAGLANDIN G/H SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI12202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1080" mass="120527" checksum="8894D3032ED1F86D" modified="2018-11-07" version="1">MSSSEAAPRAVQNGAQTNGTHVNGVKDDTKKQNPRRRPQKADTFPLSFYRQESLRPLPTETGDGTYRAVNKRPTLARDIRSIGLRDIKTVKQVIVSKLKGETQQDDKTMVMEKIIQMVATLPNRSYRQETLTNFFIDELWNSLDHPPLLYMGDEFRYRQPDGSNNNPLMPKLGAARTPYSRTVKPGKANLGALPDPETVYESVMARGAFKKNPNNVSSILWYWATIIIHDLFNTNMMDANQNDSSSYLDLSPLYGSTKEAIDSVRTFRDGMLKPDTFADRRMLGNPPGVCVILIMFNRFHNHVARNLAEINEHNRFPRPAPTTRGGRGSGLYINITLIDYVRNIINLNRVDSAWTLDPRQEMGVSAGTSKGSEAGVGNVVSAEFNLCYRWHSCISQMDEEWIQDFYRQLLGEDHGEIDLPTLIGAVKKFGMSMPPDPAHRTFNGFKRGLDGRFDDNELVDCIATAIEQPGGAFGAQNVPRIMKPVEILGILRGRKWNLAGLNEFRKHFGLKAYATFEDINSDPTVSSALRNLYQHPDHVELYPGIVAEEAKTPMVPGVGIAPTYTISRVVLSDAVALVRGDRYYTTDYHPGYLTQWGYNEVNYDFGINHGCVFYKLFNRAFPNHFRRDSVYAHYPMVIPSENRDILSNLGRDDDFSFDRPKWINPPVRVSSIAGIKHVLGNDEKYPVHWQDGLNKLMGGGGDGGGRRTVSASAGRRHLDELIYKDSWKASIKAFYANTAQRLLTDKSYKLAGQTHCDVVRDVGNLVHTHFVARLFNLPLKSADNPRGVFSEQEMYTTLSTIFMSIFFDTDPVKSFPLWHEARKQASKLAGIVETNVKITTLLGTTGLFTGKPKDDTLAAYGVNLIKGLSKAGLKAHDIAWGQILPTAGALVPNEAQLFAQAVDFYLSPRGQPHLDEIYRLASQGSSHESDSLLLGYALEGVRMSGPPGFCREASEADAYTDEHGNETRIQAGDRIFVTFDSAVRDASYFPNAGAVDPRRPIESYVHYGAEPLTRLGTEVSKLALVELFRALFRKKGLRRVPGPQGELKKVSGPSGSTVFMTEDWGAVSPFPSSMKVIWDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDE1</accession>
    <name>A0A367LDE1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDE1"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="75" mass="8442" checksum="05C40E5EAED5C6E3" modified="2018-11-07" version="1">MVVNWGNPGEDETKRRIMMTCRFAFKIEKKEEEGKKDNGKEKGGDEERQGMKGCSGWTATYPYGVTVAPVAARRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDN6</accession>
    <name>A0A367LDN6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_0294</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDN6"/>
    <dbReference type="STRING" id="1330021.A0A367LDN6"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="20"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="446"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI12543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="59109" checksum="3BC5E7209B0F5E57" modified="2018-11-07" version="1">MDYTSFILSRQPQNAASAILIDADRPHRSISWQDYASAIRRIAVGLTALGVGRQETVGLVSGNDPYFYVLADGVVAAGATFAAIATSLKETDLVSCMAAGKVSWLCASPEHLDMALAAAERTGVDRCRVIVFDPPGRNRDPYRGPQPRFSSLLADSDGSLWRNPNLGRDPTTIVALRQFTSGTTGTVKAVDVCHDILVERVKRLDTTGLAPLQQDVAALDYIPMFNVGGQMTTAKAVLGKLPAYITSANDAATILDKIHEFRVTLVQLTVPMMEEIRATIQAGTRPRDRLGSLQSVLVGGAPSRKEGVEAFTRLLPSHAILRSGYGSTETASIALTPVDSHWTPGYVGFLVDDVELKIIDPETLETLSSDTEGEICVRSPRVMRSYCNDKEATNSVFLRPDPTTQQQPWFRTGDKGYLDPTNGQLAVTGRFKEIFKVKSQHVSPSEVEDELRKHPSIADAAVTSVQARVGGGDRECIAYVVREKEGRGDGLTAHEVLDFVASRLASHKAPTGGVVFCERILRNDNGKIMRKKLAGISPLAGSAEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDU6</accession>
    <name>A0A367LDU6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nucleoporin Nup54 alpha-helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_0818</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDU6"/>
    <dbReference type="STRING" id="1330021.A0A367LDU6"/>
    <dbReference type="OrthoDB" id="6162375at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006607">
        <property type="term" value="P:NLS-bearing protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006999">
        <property type="term" value="P:nuclear pore organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036228">
        <property type="term" value="P:protein localization to nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.3600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.490">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024864">
        <property type="entry name" value="Nup54/Nup57/Nup44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025712">
        <property type="entry name" value="Nup54_alpha-helical_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13000">
        <property type="entry name" value="NUCLEOPORIN P54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13000:SF0">
        <property type="entry name" value="NUCLEOPORIN P54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13874">
        <property type="entry name" value="Nup54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18570">
        <property type="entry name" value="Nup54_57_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup54 alpha-helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="18"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI12598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="353" mass="39532" checksum="88517B68B9CCDE63" modified="2018-11-07" version="1">MSLFGQSRGLNSGSLFLSTQQQPQQTNSVLGQGGLAASQQPSGMGFGTALQSSQQAQPMPALAQSAAQLSTSLWQPGKDTPRKMYASPSRRLMLTREADQKPILDQIKLVTDKWDPASPNCVFKHYFYNKVDEAHVPFYKPQPYEDPREWEEALQNKPAPSFMPVVCSGYTGVADRLRTQTRAISDFNTRLHQVNAGLDALLQRHELETEVRALAARRRQTAIAGRCLALAARLQVLRNRGYALSSDEDDLKNRLQNLEREVQDPAMGAREEELWSRLIVLRGYSDRLKMDVDQSAGSDGEPLDSETCAKAKRILEDFEKQIGHLKKELESLGVDVEEWEKSHGSKTTKTRMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEB8</accession>
    <name>A0A367LEB8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">COP9 signalosome complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_0952</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Component of the COP9 signalosome (CSN) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEB8"/>
    <dbReference type="STRING" id="1330021.A0A367LEB8"/>
    <dbReference type="OrthoDB" id="194139at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000006">
        <property type="entry name" value="COP9 signalosome complex subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="10">
        <location>
            <begin position="252"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="469"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="481"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI12774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="502" mass="57251" checksum="8A346828127D2415" modified="2018-11-07" version="1">MSDDGDFMQQSDEEQYDFEYEEDDDEDSGDVDIENKYYNAKQLKLTDPHDAVAEFLGIPPLEQDKGEWGFKGLKQAIKLEFKMGQYEKAADHFAELLTYVKAAVTRNYSEKSINNMLDFIEKGADRPEAVQSMEKFYSLTLQSFQSTNNERLWLKTNIKLAKLLLDRKEYGAVARKLRELHRACQRPDGSDDPSKGTYSLEIYALEIQMLVETKNNKQLKALYQRALKVKSAVPHPRIMGIIRECGGKMHMNEENWTAAKSDFFESFRNYDEAGSLQRIQVLKYLLLSTMLMRSDINPFDSQETKPYRTDSRISAMTALVDAYQRDDVHAYGKVLQENQDMLADPFIAENIDEVTRNMRTKGIMKLIAPYTRMKLSWIAEQLRISEPEVQDIMCFLIADGKINGTLDQKQGVLVITSDADAERITAMRGLARSVSNFFGAIFKDGEGFRALDPASTLDETSLDSQAAALRKASRLREPAHQHQHHHQKGKKDKAAGPAMWSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEN8</accession>
    <name>A0A367LEN8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">polynucleotide adenylyltransferase</fullName>
            <ecNumber evidence="4">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_0910</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA polymerase type-B-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="4"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEN8"/>
    <dbReference type="STRING" id="1330021.A0A367LEN8"/>
    <dbReference type="OrthoDB" id="2274644at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010605">
        <property type="term" value="P:negative regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF113">
        <property type="entry name" value="POLY(A) RNA POLYMERASE CID11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="10">
        <location>
            <begin position="293"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="9">
        <location>
            <begin position="515"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="96"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="611"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="739"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="818"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1030"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1150"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="14"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="121"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="220"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="626"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="638"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="739"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="842"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="928"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1041"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1150"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1173"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1267"/>
            <end position="1277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI12889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1277" mass="137269" checksum="9BE3F0786CFD7716" modified="2018-11-07" version="1">MDGRTSTSEHQQHSYYPSSWSAAAAAVPPTPSSTASPPSTASPYDSGSSPDAVLASASTAYPHHLDFIPLLFPQQSNIYHAQLLHYNKLVSPTRGGGLQAPPIPPAVSAHHVQARTRSRSSSRVSLKEVSVGKPAAAGGHGSRTHHNQDKSRPAVASKDLQPKMAAERQPGEPPRSVPKRSTTGPSFAVQGQAHSSSVPSTPHQHARQFSFESRDPSPTVPNSHSPRSAYSETNSTLPSLRPLPPRFGGCKFETAQMNSRRRIPYSVGNDRLDRLDLRTVKARLTEEDERKLAADMGELFDRLLPTEAVEANRRKLITKLERIFNDEWPGHDIRAHLFGSSGNLLCSDNSDVDICITTSWRELEGVCMIAELLARRGMQKVVCISAAKVPIVKIWDPELGLACDMNVNNTLALENTRMVRTYVEADPRVRQLAMVIKYWTRRRIVNDAAFGATLSSYTWICLIIAFLQLRSPPVLPALHQLPHKLTKPDGSASEFADNLKKIRGFGNKNQSSVPELLFQFFRFYAHEFDYDKNVLSVRHGKLVTKADKKWTYQINNQLCVEEPFNVTRNLGNTADDYAFRGLHLELRRAFDLISQANLSEACEQYVYPKEEERTFNRPAQQPRPALLRSSSQTQSSRGGRGGGGVGGSHRGGRHNGHLLRGAAAGAGGGSNRRASSSVPSYDNGVFMAPMGLPQDVSWYQNSHFPFQYAQQDLMTQMAYQENLRQQLHLFTPTLLRHQALGQQQQQQQPRVPSGPSGSGHHQQQQQQAAAGDRSRTNSFDNVPMSAPLQPDLYALYGMSIGPQAYFPAAAGYGTYPSSPVTTNGPGPDFRRPLQRSTVTTDSGASASSSSLRSQSQPASRSPSSANPQAAAAAYQRGTQTPTGASYYAQPPTHAHGIPIPSFMSDDADFDETPKAWASASPEPEETRSATMTRVRNSSPPTVTGRARQQPSNAIAFGDLATTAPGRRRLSTDQLPQTILDRRMKRASRSPSPLGHSRANMPATAPPPLVGSQAKAISSRPLVVNGSGLRASVVPAQQHQAKAMEEARERPDERPRNGGQASTDPQGIESPTVPTTDRLPTVANGSGTSVAAAAGMGGGGGGGGGGGGGGGGDDASFRERIAMMTSYHISPQGFQQDGHSEAVTVAAVAAAASASPSTGSARLSPPGRSRWPNRPSQGGTTLPTDLATSKAAMAATESAHLSPVYETAASSPRQKDGPWLPTKVSEQKAKASASRINGHVRGAKSESDGGWQKAGKGKKKGTAQGEQAPRDETERKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LF88</accession>
    <name>A0A367LF88_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Flavoprotein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_1113</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LF88"/>
    <dbReference type="STRING" id="1330021.A0A367LF88"/>
    <dbReference type="OrthoDB" id="1532798at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071513">
        <property type="term" value="C:phosphopantothenoylcysteine decarboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359">
        <property type="entry name" value="HOMO-OLIGOMERIC FLAVIN CONTAINING CYS DECARBOXYLASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359:SF6">
        <property type="entry name" value="PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="5">
        <location>
            <begin position="30"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="529"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="302"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI13071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="568" mass="62162" checksum="438C07AFD162DC0F" modified="2018-11-07" version="1">MVTNTEPHIDSPQASAAANVALAHGDGKRHLLLAVSGSVATIKIVPIINGLAHHSNLSIRLILTEAAAHFLGGQSPEQPTLAEVRRLPNVDAIYADSAEWTRPWTRGLPILHIELRRWADVLVVSPLSANTMAKMVAGICDNLLLSVIRAWDSDGSIDGVRKKIVVACAMNTAMWWHPVTASHLRTLEEDWGGESGWVEVLRPVSKTLACNDVGDGAMVSWETIVAVAEARLGLSDDDAENRVTRPLYEDPVYLAVILKWSQRIPDCFYSCYRPVISCLRTFVDRKRRRPRFSSSPTIMSRSEIKAPKKGLDGSELCSSSTLLDQACSSTLRARLRSQEPASQPFAALPSDSGAEVFRRFRACFSLEPVCSSLPLAKDTKAPPAIEAEAMAQLRDTFAEAGLRFYTAIAEDIVQARRDMDSEIAKLTEESTAVLSRADALYSNVTYPLCVTLCHVDNGPSATIAAHLSTLLAKLSTAHGELEGLHKEWQSCVLEEREAWKELKAIDAINSNGVPKVENDAVKVAVEGFRTEAEAVIEANEAELEEIDTELRELMQGETLKIMQSMMAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFU3</accession>
    <name>A0A367LFU3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_0802</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFU3"/>
    <dbReference type="OrthoDB" id="5106181at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI13296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="200" mass="22881" checksum="9BE8EAD95A701E53" modified="2018-11-07" version="1" fragment="single">EIRIELYSGLRVEYYSTKRGLAIRRRVLAALPAIIAPYSSGTILTLVNNLPIDCDLIFFPNFLSLSVPNILEIEGEYGVKICALNYDLASKVKQLVDSLPKLLPRTVYDYFLLRTRKSYYSSYRLMHNVSSTIFFALIKIMQPDISTIFRLDSLDRCDTLFPASHNGSNYCRNAKHLYSVKDENPMPPLLVQREIPLLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFW5</accession>
    <name>A0A367LFW5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFW5"/>
    <dbReference type="STRING" id="1330021.A0A367LFW5"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="84" mass="8703" checksum="5CFC01D65D112A14" modified="2018-11-07" version="1">MPYTYKSSGTNSQGNHYCSRDYGSSAANSNSYHYSNSDGSYYYSNPNGSTYYNNGQGGSVYTPPSSQSPGSGSSSSSSGSNGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LG90</accession>
    <name>A0A367LG90_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_5542</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LG90"/>
    <dbReference type="STRING" id="1330021.A0A367LG90"/>
    <dbReference type="OrthoDB" id="10253736at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322">
        <property type="entry name" value="PKSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24322:SF736">
        <property type="entry name" value="RETINOL DEHYDROGENASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI13431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="368" mass="38083" checksum="A0D8E6B4D48E5341" modified="2018-11-07" version="1">MADPRLVPLALLPPTTVLLLVLLPSRVGCALAAFASLLWLGLASVVLSRLALNPAPAVPCRGRWDRELVVVTGGAGGIGYELVRKLEDLGASVVVLDTRPSDFPLRERSMFIQADVSDRASVDAARDAIAARFGQAPTALVANAGVLRGGGDTLLDIAEADLRSTLDVNLLGVLFCVRAFMPAMVAADRGHVIVASSVAALSPAAGVVAYAASKAALTCAVQGLQTELKHRLGNPSVKISAVFPAAVRTPMFSMMDLPVPEAIMPLLEPEEVADRMVQILADGESSGDDVDDAVSDMVMMPTMASTSSWIPAMPHWMRVAIQDAGARGTARLAAAKSRAVGAAVAGACSDGEAQGAGKRGDGMINMTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGC1</accession>
    <name>A0A367LGC1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5653</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGC1"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI13461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="214" mass="23959" checksum="0FAC69E1DE08E63B" modified="2018-11-07" version="1">MCIIWVSGPSSSCSLIRANASSDLFPMGIVIAARELGKSDFLSVGHDFSMRKNVGKKWVCLLKSVGKVESNKVFCGAVEEEEGGEKLVEMEMMISNQGVDHVIEKKKTNHVIVVFTTIEVGRYDRYWYSASIARADRCNGCLVPRLIGCYDRYRYSAPIAVTIAVTSRFGRYDRYSPTVTQGVVAGLRPNWYNLFQVALQAYFLSVQDEKICVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGD5</accession>
    <name>A0A367LGD5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_5486</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGD5"/>
    <dbReference type="STRING" id="1330021.A0A367LGD5"/>
    <dbReference type="OrthoDB" id="1287559at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000004">
        <property type="entry name" value="AdoMet-dependent rRNA methyltransferase SPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03163">
        <property type="entry name" value="RNA_methyltr_E_SPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012920">
        <property type="entry name" value="rRNA_MeTfrase_SPB1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024576">
        <property type="entry name" value="rRNA_MeTfrase_Spb1_DUF3381"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028589">
        <property type="entry name" value="SPB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF13">
        <property type="entry name" value="PRE-RRNA 2'-O-RIBOSE RNA METHYLTRANSFERASE FTSJ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11861">
        <property type="entry name" value="DUF3381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07780">
        <property type="entry name" value="Spb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 8" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="10">
        <location>
            <begin position="24"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3381" evidence="12">
        <location>
            <begin position="234"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA methyltransferase SPB1-like C-terminal" evidence="11">
        <location>
            <begin position="622"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="362"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="429"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="574"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="754"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="378"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="439"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="449"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="460"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="515"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="608"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="808"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="821"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF11861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI13478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="830" mass="93986" checksum="5C55CC3EDD6B8671" modified="2018-11-07" version="1">MAIQKKHGKSRLDKWYKLAKEKGYRARAAFKLIQLNKKYGFLEKSKVLLDLCAAPGSWCQVAAEAMPVNSLIVGVDLVPIKPIPRVYTFQSDITTEACRATIRQHFKTWKADTVLHDGAPNVGTAWAQDSFNQAELALQATKLATEFLVEGGTFVTKVFRSKDYNPLLWVLNQLFTKVEATKPPSSRNVSAEIFVVCRGFKAPNRLDPRLLDPKAVFAELSGATPNHEAKVYNPETKKRKREGYEEGDHTQFRQIPACEFIEATDPIAVLGNCNRLHFDQPTTGDVTLAALERLPDTTSEVRDCCADLQVLGRKDFKLLLRWRLKVRKIFGLSTKTPAAPETVEEVAEVESMDEEFKIQEELQSMRDKDQAKKRREKRRENERKQREIVRMQLNMVAPMDIGMEESGPIGEGSMFSLKQIDKSDALRRVSRGRMISVPNREKDRHDEMGQLEDDGESDAEGDRLERQLDSMYDNYRERKAESDAKYQAKKAREEHNDDEWEGLSDSIESQASEPSDFEEEENSSDDDGGQAPLSNLVRDLDGAGELSSGLSKRAAAFFSQTIFQGVADIVQDTAATGEGDADGYPSGNKVKRQRPIQEQTSKVKVPKHAAERHQKHEEQNGNFEMVKRTEVDDWEEATLRPNGKPDIDIVTNEAMTLAHQLATGQKTSYEAIDDGFNKYAFRDRDGLPEWFLDDESKHDKPVKPITKAAAQAIKEKLRAFNARPIKKVREAKARKKFKAAQRLEKLKKKTSLLANDEGMTEKEKAESIARMLSKASRKKPTQPAKLVVARGPNRGIQGRPKGVKGRYRMVDPRMKKELRAQKRIAQRKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGF7</accession>
    <name>A0A367LGF7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Myosin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_5520</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LGF7"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15480">
        <property type="entry name" value="fMyo2p_CBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01380">
        <property type="entry name" value="MYSc_Myo5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046943">
        <property type="entry name" value="Fungal_Myo2/2A_CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036103">
        <property type="entry name" value="MYSc_Myo5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF706">
        <property type="entry name" value="DILUTE CLASS UNCONVENTIONAL MYOSIN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50084">
        <property type="entry name" value="Myosin S1 fragment, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 8" id="KW-0518">Myosin</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="12">
        <location>
            <begin position="78"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="11">
        <location>
            <begin position="1236"/>
            <end position="1505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="8">
        <location>
            <begin position="665"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1115"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="960"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="176"/>
            <end position="183"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI13477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1593" mass="180848" checksum="01E7065D0CB35D97" modified="2018-11-07" version="1">MASTYEVGTRAWQPDPSLGWIASELVNKTIDGNKVKLDFKLENGEVTYASKTIEVPAEALQTGSDALLPPLMNPSMLEASDDLTNLSHLNEPAVRILVLQAIRLRYLQKEIYTYSGIVLIATNPFARVDSLYVPGMVQVYAGKQRATQAPHLFAIAEEAFMDMIRDSKNQTIVVSGESGAGKTVSAKYIMRYFATRESPDNPGARSKRGAESMSETEEQILATNPIMEAFGNAKTTRNDNSSRFGKYIEIMFDKQTNIIGAKIRTYLLERSRLVFQPLKERNYHIFYQLAAGASDNERRMLDLLPVEQFEYLNQGDCPTIDGVDDKAEFESTKKSLHTIGVSETKQADIFKLLAGLLHLGNVKITASRNDSVLAPTEPSLERACNILGVDATDFAKWIVKKQLITRGEKITSNLSQAQAVVVRDSVAKFVYSSLFDWLVDVINSSLATEDVLNRVSSFIGVLDIYGFEHFAKNSFEQFCINYANEKLQQEFNQHVFKLEQEEYLREQIDWTFIDFSDNQPCIDLIEGKMGILSLLDEESRLPMGSDDQFVTKLHHNFASDKQHKFFKKPRFGKSAFTVCHYAVDVTYESEGFIEKNRDTVPDEHMAILRATTNPFLKQVLEAASAVREKDVASASSNAVKPAAGRKIGVAVNRKPTLGGIFRFSLIELMNTINNTDVHYIRCIKPNEAKEAWRFEGPMVLSQLRACGVLETVRISCAGYPTRWTYEEFALRYYMLVPSSQWTSEIREMANAILTKALGTSTGKGLDKYQLGLTKIFFRAGMLAFLENLRTSRLNACAILIQKNLRAKFYRRRYLAARESVVRTQAIVRAYMARKRAQGLRTTKAATTIQRVWRGEKQRRKYLAIRKDMILFESAAKGYLRRKQIMETRVGNAALVIQRAWRTRTQLRSWRQYRRKVVLIQSLWRGKSARREYKTIREEARDLKQISYKLENKVVELTQSLGSMKEKNKNLASQVENYEGQIKSWKNRHNALEARTKELQTEANQAGIAVAKLRVMEDEMKKLQQAFDESTTSIKRMQEEERELRESLRVTNSELGTARQTSNEREKDNISLRQELETLRDALEAAKRNAPINGDLANGAATPAVASGLINLVSSKKPKRRSAGAEPRDLDRFSGAYNPRPVSMAVTNTAHRQNLSGTTYIPGVDNIEMELESLLADEDGLNEEVTMGLIRNLRIPSPSTTPPPSDKEVLFPSYLINLVTSEMWNNGFVKESERFLANVMQSIQQEVMQHDGDEAINPGAFWLSNVHEMLSFVFLAEDWYETQKTDNYEYDRLLEIVKHDLESLEFNIYHTWMKVLKKKLHKMIIPAIIESQSLPGFITNESNRFLGKLLQSNTAPAYSMDNLLSLLNSVFRAMKAFYLEDSIITQTVTELLRLVGVTAFNDLLMRRNFLSWKRGLQINYNITRIEEWCKSHDMPEGTLQLEHLMQATKLLQLKKATLNDIEIIQDICWMLSPNQIQKLLNQYLVADYEQPINGEIMKAVASRVTEKSDVLLLQAVDMDDSGPYEIAEPRSITALETYTPSWLQTPRLKRLAEIVSAQAIAQQEKLDYSDGFEGHDALVEADEASAEAAAAPEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGL6</accession>
    <name>A0A367LGL6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">GPI transamidase component PIG-S</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_5608</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGL6"/>
    <dbReference type="STRING" id="1330021.A0A367LGL6"/>
    <dbReference type="OrthoDB" id="28748at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019540">
        <property type="entry name" value="PtdIno-glycan_biosynth_class_S"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21072:SF13">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10510">
        <property type="entry name" value="PIG-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="468"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI13551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="510" mass="54984" checksum="200A634E2D473DE1" modified="2018-11-07" version="1">MASKATVSEKTPSQPSEGNAAIVSKDPPPEKPSETRKRFHIVLSFWFIVVVLGLPIWWWTTTIYRAGLPLDRMLQWAEGKATDAQHLLRLTQHALDDLDDFSGHHLRLQLAPSELESTIDPEPALTVRLTPGDANAARLDPEATALDMTYAPGSVPPPTAGSSALASWIAGELRSTFAEEQAIISHLLSPSSGLATKSLRYAPTYHLTLSLFTSGHVPSTWDVEAAMRHYLRPALDVLRPMHNFTVDTQVQLYATPGAQAPVLAKEHLASFINAAEWPLSPSIGGAPTVNFVVFVGNQTIGLAGESSETTTTTTTTTAAAQSWTIPQWGGVYLLALPPTETHVSREALRLPMLTFAGQLLTLLGTPGGGSLPLRLSALGRIRSTDLLLRASSSLGALARLARALPSISIPPSVADGVSTTLDHLELACAGLGGPKGLLHARIAEEAAERAFFEKSMVGQLYFPDEHKIAVYLPLLGPVGVPLVLGLVNEAKRRLRRREEEARRQKEKKTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGV3</accession>
    <name>A0A367LGV3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flavodoxin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_5541</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WrbA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGV3"/>
    <dbReference type="STRING" id="1330021.A0A367LGV3"/>
    <dbReference type="OrthoDB" id="504689at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003955">
        <property type="term" value="F:NAD(P)H dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000001">
        <property type="entry name" value="NAD(P)H dehydrogenase (Quinone) FQR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010089">
        <property type="entry name" value="Flavoprotein_WrbA-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01755">
        <property type="entry name" value="flav_wrbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002999">
        <property type="entry name" value="PRK03767.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546">
        <property type="entry name" value="FLAVODOXIN-RELATED PROTEIN WRBA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30546:SF23">
        <property type="entry name" value="FLAVOPROTEIN-LIKE PROTEIN YCP4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="2">
        <location>
            <begin position="5"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI13482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="203" mass="21689" checksum="C7C92E33EBD23376" modified="2018-11-07" version="1">MAPKIAIIFYSMYGHVRKLAEAEKAGVEKAGGSADLYQVPETLNDEVLTKMHAPAKPTDIPVINDPSILTKYDAFLFGIPTRYGNFPAQWKTFWDKTGGLWASGGLHGKFAGLFVSTGGQGGGQESTCLAAMSTLAHHGIVYVPLGYAKTFAQLTNLEEVHGGSAWGAGTFSGSDGSRQPTKLELDVATTQGEIFYQTIAKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LH57</accession>
    <name>A0A367LH57_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Brix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_7985</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LH57"/>
    <dbReference type="STRING" id="1330021.A0A367LH57"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000005">
        <property type="entry name" value="Similar to RNA processing factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF3">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="187"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI13774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="421" mass="48225" checksum="29EB57F435BCAA02" modified="2018-11-07" version="1">MGPKKPTTWALKAANKLKRQELFIEHKKSSSKERRVERLRRKKEEDRDPALRAARLARNKTLTLDQKRVWDDGEDDSLGAIVDLEKLRRRRIEQAEEEEKQAVRDAEMKKDDDDDDDDDDDEENDSMLDSSDEEDEKDDQEASEGIRPGGAKRDASIAPSTTSTNLDLTPSSLVLKFPSLFSDLPPPEPKILVTTSLNSTIHDDAQLISTIFPNSTYVPRSAHRYGHKYSLREICKFATNRDYTAVILIKEDLKIPTGLSIVHLPSGPTFHFTISNWIQGKKLPGHGNPTNHYPELLLNNFKTPLGLLTAKLFQTMFPRCPETQGRQIVTLHNQRDYIFVRRHRYVFREKRATEKNIVDAEGKEMKGVEGIRAGLQELGPRFTLKLRRVDKGIGRAGSEGVDATQWEWKAKMEKDRKRFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHD1</accession>
    <name>A0A367LHD1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_7922</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHD1"/>
    <dbReference type="STRING" id="1330021.A0A367LHD1"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000054">
        <property type="entry name" value="Cyclin-dependent kinase 11B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000211">
        <property type="entry name" value="Cyclin-dependent kinase G-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF107">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 11A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="102"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="393"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="37"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI13820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="461" mass="52185" checksum="404E9AE7827CC8D5" modified="2018-11-07" version="1">MAPKPASRWADTDEDAAHEVRRKAAEREARRRKKEARQREETQRKEESDAKGRPSKRRKTTPDDDDGDEETTSSLHPPTTKLTPHHTHTEQGWKKCRSVERYEKLNDIEEGTYGWVARALDKATGNVVALKRLKLEPHDRSGLPVTGLREIQILRDCRHVNVVALHEVVVGEEVSKLDNSIFLVLEFVEHDLKGILDDMPEPFLGSEIKRLLLQLVQGVAYLHDHWILHRDLKTSNLLLNNRGQLKIADFGMARYVGDPPPPRLTQLVVTLWYRAPELLLGCKTYGPPIDMWSVGCIFAELVDREPLLQGANEMDQTANIFLLCGLPDKNSWPAFRSLPNASGLKLPRDAPATSAVRRRFPTLTSAAVSLLEGFLALDPDRRPSARDALRHEYFRQDPKPKPENMFPTFPSRAGQERRKRREPHAPVRGQSAAGLGDADFSGIFQGRDREERGAGFTLRMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHF1</accession>
    <name>A0A367LHF1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_8269</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the eukaryotic/archaeal RNase P protein component 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHF1"/>
    <dbReference type="STRING" id="1330021.A0A367LHF1"/>
    <dbReference type="OrthoDB" id="128536at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007175">
        <property type="entry name" value="Rpr2/Snm1/Rpp21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14742:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14742">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04032">
        <property type="entry name" value="Rpr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="132"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="183"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI13866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="193" mass="20994" checksum="8ADFD7344E39DD02" modified="2018-11-07" version="1">MAKSKSSPGVQNRAIFSRASYLYQAATYLSQRAATTTTSSSSSSSQTHQRKQLRNLSRRAISEMRAVTRKAQIRQSHPLKRSLCTACNTLLVEGDTCQSTIENPSKGARKPWADVLVVRCVTCSRPKRFPISAPRQTRAALRRSASGSGSRSSGNSASGTTGEREPSKGEERGEVASLNQNEDSSRGIEMKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIC4</accession>
    <name>A0A367LIC4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">protein-ribulosamine 3-kinase</fullName>
            <ecNumber evidence="1">2.7.1.172</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_6071</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>N(6)-D-ribulosyl-L-lysyl-[protein] + ATP = N(6)-(3-O-phospho-D-ribulosyl)-L-lysyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48432"/>
            <dbReference type="Rhea" id="RHEA-COMP:12103"/>
            <dbReference type="Rhea" id="RHEA-COMP:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:90418"/>
            <dbReference type="ChEBI" id="CHEBI:90420"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.172"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="2">
            <dbReference type="Rhea" id="RHEA:48433"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the fructosamine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.172" evidence="1"/>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIC4"/>
    <dbReference type="STRING" id="1330021.A0A367LIC4"/>
    <dbReference type="OrthoDB" id="5772781at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102193">
        <property type="term" value="F:protein-ribulosamine 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1200.10:FF:000018">
        <property type="entry name" value="Fructosamine-3-kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016477">
        <property type="entry name" value="Fructo-/Ketosamine-3-kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149">
        <property type="entry name" value="FRUCTOSAMINE 3 KINASE-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12149:SF8">
        <property type="entry name" value="PROTEIN-RIBULOSAMINE 3-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03881">
        <property type="entry name" value="Fructosamin_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006221">
        <property type="entry name" value="Ketosamine-3-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00048655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR006221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI14174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="333" mass="35969" checksum="642C7E729C6CCE65" modified="2018-11-07" version="1">MSVDPAILEALGLDDDEAQAKIASHGGSNFSSTFKLTTTNNSNERRNFFVKTGTGRDADLMFRGSLLTSAREHASLNAINDAVPGFCPRSHAHGAMKSTSDRFFLVTDFVDFSSAASSPGSRVSLAARLAKLHTTPAPVPAGYDAPVFGFPESTFCGETAQDNSWKTSWADFYADNRLRGILRSCIAKNGSDADLADAVERVAATVVPRLLGDGHIRPDIVPVVVHGDLWNGNHGIGRIGGGGGVENVVFDPSAAYAHSEYELGIMRMFGGFGPDFWTEYHKLVHKAEPVAEWEDRIMLYELYHHLNHFAIFGGGYRGGAMAILRKLTAKYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIW9</accession>
    <name>A0A367LIW9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIW9"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="356" mass="39975" checksum="88D195DECB08C673" modified="2018-11-07" version="1">MTSIKQLDLNSIPTGIVKLKGQDNWLNWEMHIRMAIEQFRLLPYIDKSDGGKPRESDLAAMEKWQDEEVYCRRLIVHHCDDAILHGIRDGGWVSSHTAYQTLEAIKKKCNAAPRVTFALMMEEMFTMKAETFATFGAFVRRLNLLWDQLNVVMPNQSKGWFIGAAINAIKNCMPLRYEDYMHRLADQKPPTKTEILAFFQSHADLIDNTKKDAFSADLSGSGTKTQDRGRGRGRGGRGRGRGGRGSQGGRPSSSSPSMIIGPDGRRGQYLDCGCFIPESSRPHTEDQCWKLHPELRPPPRSIDQPPYQQKQITASESITKAGQNYELIAASRCFIEISENTTLDPFRAADGGDLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJB0</accession>
    <name>A0A367LJB0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutathione hydrolase</fullName>
            <ecNumber evidence="8">2.3.2.2</ecNumber>
            <ecNumber evidence="8">3.4.19.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Gamma-glutamyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Gamma-glutamyltranspeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_6097</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 8">
            <text>an N-terminal (5-L-glutamyl)-[peptide] + an alpha-amino acid = 5-L-glutamyl amino acid + an N-terminal L-alpha-aminoacyl-[peptide]</text>
            <dbReference type="Rhea" id="RHEA:23904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9780"/>
            <dbReference type="Rhea" id="RHEA-COMP:9795"/>
            <dbReference type="ChEBI" id="CHEBI:77644"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:78599"/>
            <dbReference type="ChEBI" id="CHEBI:78608"/>
            <dbReference type="EC" id="2.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>an S-substituted glutathione + H2O = an S-substituted L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:59468"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="ChEBI" id="CHEBI:143103"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 8">
            <text>glutathione + H2O = L-cysteinylglycine + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:28807"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:61694"/>
            <dbReference type="EC" id="3.4.19.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 8">Sulfur metabolism; glutathione metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the gamma-glutamyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.2" evidence="8"/>
    <dbReference type="EC" id="3.4.19.13" evidence="8"/>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJB0"/>
    <dbReference type="STRING" id="1330021.A0A367LJB0"/>
    <dbReference type="OrthoDB" id="1081007at2759"/>
    <dbReference type="UniPathway" id="UPA00204"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036374">
        <property type="term" value="F:glutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103068">
        <property type="term" value="F:leukotriene C4 gamma-glutamyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.40:FF:000001">
        <property type="entry name" value="Gamma-glutamyltranspeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043138">
        <property type="entry name" value="GGT_lsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000101">
        <property type="entry name" value="GGT_peptidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043137">
        <property type="entry name" value="GGT_ssub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00066">
        <property type="entry name" value="g_glut_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686">
        <property type="entry name" value="GAMMA GLUTAMYL TRANSPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11686:SF62">
        <property type="entry name" value="GLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01019">
        <property type="entry name" value="G_glu_transpept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01210">
        <property type="entry name" value="GGTRANSPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016802919" description="Glutathione hydrolase" evidence="9">
        <location>
            <begin position="29"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="398"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="416"/>
            <end position="418"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="468"/>
            <end position="469"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>L-glutamate</name>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600101-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU368068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI14490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="588" mass="62994" checksum="18570CE589BDB9EC" modified="2018-11-07" version="1">MGSSQYTRLSIYPVILLSLLVAARCCHAVPLSILLGPSANPGAGGAVVSEASECSYIGKDLLARGGNAVDAAVGTTFCVGVIALYHSGIGGGGFALVRDERGRYEAVDFRETAPAAAYQDMFLGNVAGSMSGGLSVAVPGEVRGLEYMHGKYGSLPWKTVLQGAIRVARDGFRVSRDLAHKMTDKKRCYLLQDASFALDFAPHGVFHRRSPSFANLTRQPGTLLREGDLMTRKRYARTLERIAEEGSAAFYSGEIAEAMARYVQATNGSMTVDDLERYTITSRPVQRVRYRGLDLYTVGAPASGVVGLSILKAAEQYAPTADAGLAAHRFVEAMRFGYGVRARLADPDFVPDVVALEEQLLDERYARHVRQLINDNATLPVRDYHPGFEESVPESHGTSHIVTADADGRAVSLTTTINLVFGAQLMEPLSGIVLNDEMNDFSIPGSPNDFDLPPSTANYIAPLKRPLSSITPIIASDPDGSLRAVVGASGGSRIISATVAALWHLVEHGTSMAEAVRAPRMHDQLIPNVLLLEYAFNNDTADALAARGHNISRVAEGLSAVQGIRIRADGSFEAAAEPRQSNSRGYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJG8</accession>
    <name>A0A367LJG8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJG8"/>
    <dbReference type="OrthoDB" id="932129at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="81" mass="8903" checksum="CA08F93692177407" modified="2018-11-07" version="1">MAGVKSALPSHLRPAGDGSDDNGFERRHHGKTRSHMATKKNKTFDLGLLDTRTSGPPFSRLPFVVRSLAVPELFSAVRSRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJU4</accession>
    <name>A0A367LJU4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6987 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_6814</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJU4"/>
    <dbReference type="STRING" id="1330021.A0A367LJU4"/>
    <dbReference type="OrthoDB" id="3937590at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022124">
        <property type="entry name" value="DUF3659"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054256">
        <property type="entry name" value="DUF6987"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39461">
        <property type="entry name" value="LEA DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G04920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39461:SF1">
        <property type="entry name" value="LEA DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G04920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12396">
        <property type="entry name" value="DUF3659"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22485">
        <property type="entry name" value="DUF6987"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6987" evidence="2">
        <location>
            <begin position="1021"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="596"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="752"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="980"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="389"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="596"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="614"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="626"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="752"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="780"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="997"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1019"/>
            <end position="1030"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI14647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1230" mass="129474" checksum="4571A18E30E2DE2F" modified="2018-11-07" version="1">MPVKNPFSVPGSWGKDTGEATSTTNNSEAIPRNAAGIVGKSGDILDQSGKSIGNVSDAKDAEALAGSAVTTTGDIINASGDIVGKASLESEYTTRPDSKSGGWNVLGKTKGVIQTVDSIRGPVNKSFELAGNLSNLQGKSGDKASGVEGGEDDHHSAASKGERKDAVGNSAVKSSAEGQGEKASSISKTDSVADADHHQQQQQQPAIRLQDNDDGSAATDRGTAKHETSAASTVGKHEEKQADEPLAVQDPVPIDEKSETGVKSEPLKPADSVSEHGSGTVEKDPSSAVAPASEQVKSEARRTDVAPPEAGHLKGSSDLPAEQQSSELAAELQSRKGTEKATSEQAEGKASTTGLAADQTKEAAPSELGSAKMTTKSMLSKATGEADEATAAKAAKGEATSEQAEGKASSSSTTTTTGLAADQTKEVAPSELGSAKITTKSMLSKATGEADETAAAKGEAPSDLGSQRAADKAPSTLGSVKASSEKVPSELGPEKAHSEAEEAQGEEVKVEPSSGDATGQGGEEGEAMTTKDDKEEAVMMKDDEEEEKKEAATIKYGLLRGTKVNKSGKLVDSDGDVIGKLVEGDVKKLVGKMADEEGYIKDQEGNKLGRGEPLADDELPEGLVDELSKKKEEEEKKKKEEEEEEEPTLDYSVLKGTKVNKAGNLVDGDGDIVGRLVEGEAKQLIGRRADEEGYIWNDSGKKVGRGEPIADAERDAAKSFAPFENFPDAVVEADGRVTSEGRQVGTVVEGDPKRLKGSKVDEDGDILDRRGNVVGKAEAWDEPEPPPEEEPERPADRSALAGKRVNKAGNVVDSAGVIYGRVVEGDVASLVGRMCNRDGNVMSESGEVIGRAELVPEHEREGRRDGPFADLVGCTVTKDGKVVTSAGDVVVGRLTSGDGKTLYGRRVDQDGDVVDRNGNVLGKAERWEEPVVEKKRDALAGRRVNRDGNVVDEDGNIIGRLISGDVAICSGKEVDDDGDVINSKGMTIGHVSRLEDIPPEPEVEEPEPEVEEEEESAEEKEKREQAEKDRKLAGQLSAAIEQSLDRIRPVCKMILDKIERAERTPKEELDEEQLVREVKPLIEEGHRILTETNGVIRGLDPDGRIQRNAKAKAGTREATPEEHHLAEVLKELTGTISETIDKARRMIDGMPHAKKELNPLWGLLSEPLFQILAAVGLLLNGVLGLVGRLLSGLGLGGLIDNLLGGLGLNKILGSLGLGGALDALTGKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJW0</accession>
    <name>A0A367LJW0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7088</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJW0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="66" mass="7377" checksum="FE35B7FA809E1182" modified="2018-11-07" version="1">MFLPSYGPYGPAVTYSLSASYVVMPFLPLLCDVRRPRAGYGRPGVTVWRSRQNSAYNRSSSKSPIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKK5</accession>
    <name>A0A367LKK5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HCP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6841</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKK5"/>
    <dbReference type="STRING" id="1330021.A0A367LKK5"/>
    <dbReference type="OrthoDB" id="2148946at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052945">
        <property type="entry name" value="Mitotic_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628">
        <property type="entry name" value="ACTIVATOR OF C KINASE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628:SF1">
        <property type="entry name" value="CHITIN SYNTHASE REGULATORY FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="404" mass="43923" checksum="188EFE181D827CD1" modified="2018-11-07" version="1" fragment="single">VRLQKRKMKGDNQPPEFKLVVRSDTASLSAEAPLSAPAALASEPTATSSSSLTTPTTTANTTTHGWSARRSIDQILHRHHHDCHPHRNRSRSASASSAGTTTEDVTTTTTTARMKSQRRLSKRLLHRLGLGDDDDQGQGRRGNNNNNNNNNDEDALPPLSRTGDDEYWERRATKLAGIHDSSSQQQPQPEEVASRQTDKDIQEAIRLHESGHLEQSTAIFARLADRSGPNNALSQVLYGLALRHGWGCAPDPEAAVRFLSAAASGAASVEQLALHAGLARGGAAKGELVLAIFELANCFRNGWGVPTNAVAAKQYYETAANLGDTDAMNEAAWCYLKGFGCRKDKVGKKNKDAIHVWDGLADDAQPQQFAAARYYRLAEKAGSKTLGNSWIWKEKYDPPANKTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKK7</accession>
    <name>A0A367LKK7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_7105</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LKK7"/>
    <dbReference type="OrthoDB" id="10258608at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056604">
        <property type="entry name" value="GBF1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF388">
        <property type="entry name" value="GOLGI-SPECIFIC BREFELDIN A-RESISTANCE GUANINE NUCLEOTIDE EXCHANGE FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23325">
        <property type="entry name" value="TPR_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="2">
        <location>
            <begin position="634"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI14930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1563" mass="173217" checksum="27C55A956FE04B4D" modified="2018-11-07" version="1">MKRDDQFKSDSSAAIPLAHASDIPRMSYRSRPVTISVDPTSLVISECISITSAIQKHAPHSSVSAILGGSPSPIQLVTSSVVPGSRSRVATPVTRTEDGNPEAIVTNNRWGLRGHRGKSMQDNPMVAGFGKLRHEIAAAKDIHSLDAPSLLAPFLQVLQAKGTAAPITILALGALRKFLAYGFIGIESPRIAVAMQSLSAAVTHCQFDVSDSTQGEVVLLMILSLMEDMMSGPGGYILSDESVCDIMGRGLAICSQPRFSPVLRRTAEASMIRMCQIIFEDVKHLEGAKAWNDSEKPDQRFCKMEQMTPICPQTRSSHEDDYDINSAALSTSSPPSLERTAASGPEDPISTPSPDVGSEEADDSQSMDLQPYSLPSVRELFRVLVNFLDPNDRQHTDTMRVVALRILHVALEVSGPFIARLPALAIIVEDRLCCYLFQLVRSDNMAVLQESLIVAGTLLATCRGILKLQQELFLSYLVACLHPTVHIPRETGIDPSLYSDIPETPNLVKQPASQRDSGRSTPVSIKDRQKLGLEGGTRKPDARQAMVEGIGVLSRMPTFVTELFVNYDCDEDRADLCEDLIGLLSRNALPDSATWSTTSVPPLCLDALLRYIQFLAERTQDNPAFERSFPDPAQLRERRRRKNIIVKGAIKFNEKPKVGLRYLEAHGIIADVGDPVGVARFLQGTSRVSKSVLGDFLSKRGNEAVLGAFIDQFDFSEKRIDEALRVLLETFRLPGEAPLIASIVESFSEKYCRGNTLNNVANKDAVFILTYAIIILNTDQHNPNLKASKRMTFEDFSRNLRGQNSGQDFSRTFLQDIFDSIRLNEIILPDEHDNKHAFDYAWRELLSKSASAGNLIMCDTNIYDADMFTATWKPILSTLSYVFMSATDDAVFARIVAGFDDCARIADKYENTEALDQLVYCLSLMSTLATEITCNTSLNTEVQVGNGSVMVSELAVKLGSNFRAQLAMLVLFRVVTNREALLRRSWKHIVTIWRNLFINSLIPSLASACHPPLIIPSIPLQTPSQTIDRASRSTESGFFSAFTSYISSYAADDPPEPSEEELDSTLCTVDCINLCGMSNVFRNVMNLPAQSTSSLARALLDQIPENDRVAVISVKQDSVPSPPSINQGPTVVAPAYDPSTVFILEFVTILATRDDASVEAVGKDVFDVLQTLLRDFTNWHPIMLSRAAFYTFLILKHGYDHDFINVPFLLHSINSLTRDLLFRSSEVILQGLAICTDQPGPLRSEIMTSPDFWAIMRVLAGNLDSAALVFRVLEKGSTGSPPAIMAENYEPAVSLLVHFASGAKPHESVGDKEYVPERKMKKDPSIRDKQSIERACKAVEILHGMTGRVPQLMHQSHLESSEAWATYWLPIFQALTTQCTNPVRDVRQLAFSAMQRSLLSPELACSDVKDWSAVFDKVLFPLVFRLLKPEIFSLDREGMSDMRVQSASLLCKVFLQYLVLFSDWNGMLDLWIKIIEVMDRLMNSGQGDSLEEAVRENVKNVVLYMASIGCLARTDTTRVDVWEETWRRLDRFLPDLRKDLLADDLGKDHVASDLQSKREVASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LL05</accession>
    <name>A0A367LL05_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_6806</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LL05"/>
    <dbReference type="STRING" id="1330021.A0A367LL05"/>
    <dbReference type="OrthoDB" id="4509994at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI15067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="97" mass="11105" checksum="E73E27783C60F80B" modified="2018-11-07" version="1" fragment="single">KIRTNKATFRDKEDRIGFLFCSLEGKACKTLETYLLTKTKDNSLSYKDFCSYIKDSAIKRLDTELVLPNNLPAFAKYSLSILLPKTPLLNRQIDLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LL30</accession>
    <name>A0A367LL30_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM2-LSM8 complex subunit LSM8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LSM8</name>
        <name evidence="11" type="ORF">L249_6798</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LL30"/>
    <dbReference type="STRING" id="1330021.A0A367LL30"/>
    <dbReference type="OrthoDB" id="422364at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01727">
        <property type="entry name" value="LSm8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000027">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034103">
        <property type="entry name" value="Lsm8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044642">
        <property type="entry name" value="PTHR15588"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588">
        <property type="entry name" value="LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588:SF9">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI15144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="99" mass="10702" checksum="A0CF1E4E8C25A8F3" modified="2018-11-07" version="1">MATLGGYLNKKVLVVTVDSRTLVGTLLAADHSTNLVLDKAVERVIREPDDPENSLEVTLGVYVVRGDNVCVVGLVDEKLDQSIDWTKVRGSVIGSTKHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LL98</accession>
    <name>A0A367LL98_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_6672</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LL98"/>
    <dbReference type="STRING" id="1330021.A0A367LL98"/>
    <dbReference type="OrthoDB" id="2867507at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20558">
        <property type="entry name" value="CYCLIN_ScPCL7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02002">
        <property type="entry name" value="TPP_BFDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006203">
        <property type="entry name" value="PRK08327.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF164">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="6">
        <location>
            <begin position="94"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="4">
        <location>
            <begin position="299"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="5">
        <location>
            <begin position="502"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="55"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="720"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="823"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="847"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="881"/>
            <end position="905"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI15032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1102" mass="118096" checksum="6036C8FF2102EE65" modified="2018-11-07" version="1">MSVLRGTALSSPALSRFRVALITTASLPSGIRHRSSLCHRGSLAHITEAVASVPPIARSSRPSSDSTHNAHPAAARLSSTSSAPAKDPNNMYTASFAFFEAIWEAGITHCFVNLGSDHPSIIEAMVKGKREADGRFPRIITCPNEMVALSMADGYARLTGKPQCVIVHVDVGTQGLGAAVHNASTGRAPVLVFAGLSPFTLDGELRGSRTEYIHWIQDVPDQKQIVSQYCRYAAEIKTGTNVKQMVNRALQFARSDPQGPVYLCGAREVMEADIQPYALRQRDWDPVQLGPLPQSGADSIADALVEAERPVLVTGYGGRNHKFPDAVVKLADKVKGLQVVDSGGSDMCFPADHAAWRGLRFGVDDAISKADTILVVDCDVPWIPTRCRPHEDAKIFHVDVDPLKQQMPLFYLGAGARFRADALAAVEQITAALDDGPRADKLKAKSSDAARNKDYRELMDGIAEKAKPLQDGSFGTGHLAQTLKKLCPEDTLWVVEAVTNTSFVHDNLQPTRPGSWINCGGGGLGWSGGGALGVKLATEAESGGKGKFVVQIVGDGTYLFSVPGSVYWISKRYKIPVLTIVLNNKGWHAPRRSLLLVHPDGLGSKASNEEVNISFDPTPDYSGIAKAAADGDIFAARVSEASKLEGVLKEAIANVQAGQTAVLDCSFFNTRCDIRAQLVPSIGARMGLGRDTDVVIAQYLLPPYWFLGTRMSATAFFSPEAGGPSTGSDACPPPPPVPSSDPGVAVTTGLSVSTPDEHDLSKLPPIEALELLSAGVELLVRLTGDIPPTPPSKTPTDPMMSGIQAEKADIARSHSDKNLALSARHPRQADSKPANKSPPSQDCAGAGRDGGGDDGGGGGGGGSGGGGVGGKGLSKLEMYSAQLRAQQQAKQQQAKQQQQERQQMQHGDADPDGGIDGVRLRHETSPISDTQPYVVIGDDARPVNIQHEAITRKFYSKKEPPIGVGQYLLRLHQFCPMSSAVYLATSLYIHRLAVEERAILVTRRNAHRLLLAGLRVAMKAMEDLSYPHNKVAKVGGVSELELARLEISFCFLTGFELIVGEEAMRRHWETLRDGRAKQMLRSSEPPDLRLGKRPRELTAAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLD9</accession>
    <name>A0A367LLD9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutathione S-transferase kappa</fullName>
            <ecNumber evidence="1">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_6446</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily. Kappa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="1"/>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLD9"/>
    <dbReference type="STRING" id="1330021.A0A367LLD9"/>
    <dbReference type="OrthoDB" id="4664297at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004602">
        <property type="term" value="F:glutathione peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001853">
        <property type="entry name" value="DSBA-like_thioredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051924">
        <property type="entry name" value="GST_Kappa/NadH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014440">
        <property type="entry name" value="HCCAis_GSTk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42943:SF13">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE KAPPA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01323">
        <property type="entry name" value="DSBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006386">
        <property type="entry name" value="HCCAis_GSTk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DSBA-like thioredoxin" evidence="3">
        <location>
            <begin position="6"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR006386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006386-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI15197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="224" mass="25056" checksum="0700ED12914E2A90" modified="2018-11-07" version="1">MGGGRIDCYLDIASFFSYVAFVDLLANVDKLAAHGVKVDFRPVFLGAIMKGADNKPPWMNKAKGRYLVHDTRRAALQVGLTEWAMPKDLLSLAKTPSPLRALLFIKANYPPSTFHQAMLRLFRRFWKPPHANLWDDAVLRSALAEGGLFSALEVGRIMDGRESMRRRLEEETSSALGLGAFGAPWLWVSDGEGRAEPFFGSDRFGQIYRHLGVPHRKVEVVAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLE3</accession>
    <name>A0A367LLE3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NFACT RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_6694</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLE3"/>
    <dbReference type="STRING" id="1330021.A0A367LLE3"/>
    <dbReference type="OrthoDB" id="200398at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039730">
        <property type="entry name" value="Jlp2/Ccd25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13049:SF2">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13049">
        <property type="entry name" value="DUF814-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT RNA-binding" evidence="3">
        <location>
            <begin position="69"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="172"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="172"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI15253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="244" mass="28748" checksum="DB23A70378DB9581" modified="2018-11-07" version="1">MVYYFTSNVVDPHATIYVGKDKFESWHLALPPPHHTSRSRLTAMLRRGPDQVWLGPRCLVGAQNRLPHLFHVDKLSSAHVYLRMQDGQTWDTIDESLIADLAQLTKANSIEGTHPSSIHFLYTPWSNLKKTDAMEVGQVSYKDPREVKRVLVVHRENAIVNRLNKTKVEKKPDLQRERDDRLKELRRRDQEEQNQRRKEEARQAQEWKEKKWQKDHAYDDMFTEDNMAASSNQDRGADWEDDFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLP5</accession>
    <name>A0A367LLP5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription factor hoxa13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_6735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLP5"/>
    <dbReference type="STRING" id="1330021.A0A367LLP5"/>
    <dbReference type="OrthoDB" id="3260408at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23242">
        <property type="entry name" value="TRANSCRIPTION FACTOR HOXA13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23242:SF9">
        <property type="entry name" value="TRANSCRIPTION FACTOR HOXA13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="270"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="583"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="699"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="364"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="271"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="708"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI15338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1154" mass="123562" checksum="82C6365175BFEC00" modified="2018-11-07" version="1">MFDSGVLSAQGPRAANGKLNGKLTNWPKRAKRRRGFFSWASNLVARLAIWSAILTLLFRCPPSLEACDETSPYICKNYFLAKNVVAPRIQPYYHRYAAPYVHIAKPYYDALDGHVLTPTRTYALHFGAPWINRARGYTWSQWEIKGQPRLAQLQALSAAYYDRSIAPHLAQAGRIVEPYYGTARSNLLQLYYEYAIPSYELVHPHAVRGYSVARQFASNTALPATYWVWNKGNVFLETAVWPQLRSLYVENVEPQLVRIGERLGRYKNKAQSKVLHQQPSSTSFSSKPEVSSYKTTHPDSTPGSSAVEDSVVPDGSDGSAFQDNGPKYIHPVEPPTALENEDAEGRAVREMVTNDLEIWQEKFMSQAEEKAHEIEDRVDAIARRNMELHIYTAGKDLLEQLHSTVESEVEQLKRNIISIVKMSAEDAQDSAIAAVRSAGVAVKNSAQAIREWREKFDAQLKATVHDDVEEYFDILDETRSLALQKIGMKWAWTNGVSYHDWAKYHELKNALTKLTDDLRELVVTHPGLVEAQDASAHVEDEAMTIAADAARELARLKDVARWKILAGDSTDSFDSELMKLAAEKAGEGPAESQSPTDHGSKETLGKGFSPAMKPLDSVGETWPSTAAHSWSEEANHVSQGPNPPASGRPGGVSHEGHEFDKQKVSLEEKSGNTANDDETVDIGGHWSLLWASSANMAPDVSEQTPAAELDDSHDDEADAKTRPSQSGATRVNRVAFGAAAQEVSNRGPILDKVGEPDVYASATSAAQAAYSSAVAAASDRYSSALSVVSAQVYGTPNPVHKQLMASVSAACGNAVTAASQKLDKAVSAASYGVYGEPTPTSGLGSFGWDKVESIAAQRLNEGRLWAEVQYQSALMALGMATATASPTASVDKFVEQAKFRYYAGIGIAQDRYTSFLSAASSAWSSVTPTSRPTGLVGSASSVASVASESASSAAQAAGSVAQAAGSAAQSAYSAATEKVASAARAVEDSFSSVADAASEQMFLAGAAIAGTWDQVVSELSVQVYAEPTAIGWHDRLLEGAGSYASCATKTAADKAGTATEAAYDAADVASSQVAKQLGAVSKIVSELISGREPAFSESVLSRLGAIYATASASFGSVASEVSVSAASVGESVRGAASQATKAVKESIQQGRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLQ2</accession>
    <name>A0A367LLQ2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Malate/L-lactate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_6546</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH2/MDH2 oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLQ2"/>
    <dbReference type="STRING" id="1330021.A0A367LLQ2"/>
    <dbReference type="OrthoDB" id="7881616at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.60">
        <property type="entry name" value="Hypothetical oxidoreductase yiak, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043144">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_ah"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043143">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036111">
        <property type="entry name" value="Mal/L-sulfo/L-lacto_DH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003767">
        <property type="entry name" value="Malate/L-lactate_DH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091:SF0">
        <property type="entry name" value="MALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091">
        <property type="entry name" value="OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02615">
        <property type="entry name" value="Ldh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89733">
        <property type="entry name" value="L-sulfolactate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI15348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="37920" checksum="A4D61BD78C5B7768" modified="2018-11-07" version="1">MASSDEPRLRVAADDLVRLVDKVLQAHGAPPNHAALVARCLVAADLRGVDSHGASRLPSYVRRIRAGVLDPAAVPVLHQVTPAAVRVDGANGFGFVAAHAAMAAAITAASTYGIGLASVRRSNHYGMAAWLVRQALDAGCMSLVFTNSSPAMPPWGGRSRLLGVSPMACGAPGRDGDDFILDMAPSVVARGKVHTALRRGESIPPGWALDADGNPTEDPAAALDGGVMLPVGGPKGSALAIMMDVFSGVLSGSAFAGNVTGPYDPSQPADVGHFLVAIRPDLFIPLDEFRDRMRYLYERVVGADRAPGVDRIYFPGELEQLTQRERERSGIPLAKAEVEALNREGADVSVEPLEATLVGEQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LM04</accession>
    <name>A0A367LM04_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_3594</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LM04"/>
    <dbReference type="OrthoDB" id="422827at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09535">
        <property type="entry name" value="SAM_BOI-like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="3">
        <location>
            <begin position="175"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="666"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="493"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="566"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI15466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="841" mass="92632" checksum="BDD2F93B7856B45F" modified="2018-11-07" version="1">MMHHVTIRDCEARLSHKMRAKPTDETLVPLKNSKRPVSVATEFVDTDWDEEIVSDVEDNSPRVSLQSLGQPSITTVSSYDEAPTPRSSTGRGGYIETLIDSCPKQTQGPRGPHLFRSSTDPGFVDDDYTLSLSPLVPHYSHDELRKLEEQPPIFPQGSPAQKVGRKLGTSSLASWTPEMVAQFMMDAGFDISVSDRFIENDINGEIVLTLKFEDLRELDIPSFGIRTRVWHQIQSMRDSRPSPPRPSTPIEDVPSREARKEARAASRAESEVQRRQSSRPRHRRRPSTAAHNDGGVTSTDPPVSIIGIEQVVPKAHHCSKGENCSKWKRQQRAIDEFQKAHPNVDVNAGGTVLIFGDAGNPETAKAIDADQDLLPQRPLSDAVHSVAASSDVFGPAGQPPMLLMQQQQYLQEAALRDVRCRDPQDNVRQFLNFQYQQDGGGTNEIPPTPPFELVPAATYPPHCGLRRLPRLSIPGKAPSLRRPSLAQMFPEHQLQGPTSCCHPNTSVSHSPDVGSGDDSRRLGSPFSELDVPVTVTQAGPVARNVSQSVPPDLGHRASPPSGPGHVRSQSRVSVRRPSFPVLPSLDEHKAVSSSMDSCKSPRAKTPSAKPSSGRSSCQQPLQAPPRFNYPWTPIESCNAVEQTLPPTGLHTTTTTTLPNSQETVEDISFQGPMRKRKMRLFRHEWQDAYFTIRGTRLNMHKDAREVDRTLEYIDIDDYAIACSNLASSSKLSAAFKAMHISHSRGKSDPISAFSFQLIPQDKDAAGLRLRKRESSLNSGGSGNGSEASAEGMAAVNGTGKTHHFAVRSREERIDWMRELMLAKALKQKGEGFEISVNGNMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LM23</accession>
    <name>A0A367LM23_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LM23"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="42" mass="4901" checksum="21D92B365AB9C3AA" modified="2018-11-07" version="1" fragment="single">MEASLPEVECKDRSRNCLRMQATKRATSEPDKHRLEELVLQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LM62</accession>
    <name>A0A367LM62_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7603 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_3511</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LM62"/>
    <dbReference type="STRING" id="1330021.A0A367LM62"/>
    <dbReference type="OrthoDB" id="5395440at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032982">
        <property type="term" value="C:myosin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056023">
        <property type="entry name" value="DUF7603"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF40">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24554">
        <property type="entry name" value="DUF7603"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7603" evidence="3">
        <location>
            <begin position="773"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="106"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="148"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="358"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="533"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="595"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="951"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="205"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="373"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="386"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="542"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI15526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1034" mass="114850" checksum="2B4C7D96CE9E8799" modified="2018-11-07" version="1">MALPPASPSLDTLPSSDILRNDAPLPHHQTHGSLPQNPQREHLRSLEASQSVLHSAIDSPPSPPSARPTSTPVVAPCKPEQRFARPLSVDSPTLYEFASPARLLRHSYESPAEPLDADTGTPEDRTYIPAASDSHGLLDVLSGYDDLISEPSGSVYDASRDGDVDEDDEDGLELPHNRNLLPPPMFASRSIAPNLTLDKVDTAVAQRQHQSNPESPSPESARHSRPPPKSPSQASPFTSLFGWGNPSPSVTDFSSIPSPVSPTRSRSTDEAHKSSKNPDPNAAEADPLDYCEAYLSTPPPPLALPLPLPPPPPPPPPPQASSSIQVEEMEEELKAISSELAASIRREMDLEDLVDRLQEQVSNPQGAGKRTSDYFSDSGNSSAKLSEYEQSREEVDKVQRRAEQEKASIRLELTTKLQDERSKRKVLDQQIKDLAEKASQIDLAQINNLDANSRVRDLETTCEDLRRRLSEERESKDNFGDLLSALKGELHDACNERDNLRDEVVPQLRARVEGLESEAAAYTNLTYESTKMQQQLQSLQQENTSLRGSSGANIPEDWRSLTRSNSTAAASFRPRGPPGGLARSDSVKNAQAESRDQLFERLKDVEAQRDALHSALKNLLERQEFQNRENRKKIEVLEGERRRLLSESPKKAGFERDIANLRTEINVLRRRAEDALEQKWQVEKGLVGLKMDLDRAEEEIASLRSLLKENDILTPPPVARPGSASGTPAVPVTSESLERAYRELQDAYRESLDRIKSLEASGGVISDEKTRLAMQRLEQSLSSAVSERDAAQQQVSNFRNQVGSLTDVESRSIQREKQLADELSESAQRVEQLAAEVRQQLSKNAELRERLTSTVARGDAERKANSDRISGLQERLHALEEQLVAAQTASEDRVGRHEEEIAHLRESHNEQLRRLNNGTGSARGSKTKSHLLRSESPKMFGRSGQVMPAKSFEDEAQVNELRERVTELEKALADAETEIQLVVAKMSTAQIEVMNLQEEREAAVRETRQLMKTISDEQLKSFKDRFQTLNSMVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMU3</accession>
    <name>A0A367LMU3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8004 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_3492</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMU3"/>
    <dbReference type="STRING" id="1330021.A0A367LMU3"/>
    <dbReference type="OrthoDB" id="5300331at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058317">
        <property type="entry name" value="DUF8004"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39601">
        <property type="entry name" value="CHORIOGENIN HMINOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39601:SF2">
        <property type="entry name" value="CHORIOGENIN HMINOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26013">
        <property type="entry name" value="DUF8004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8004" evidence="2">
        <location>
            <begin position="454"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="852"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI15562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1007" mass="111447" checksum="A1B2863B5E87F100" modified="2018-11-07" version="1">MPDVSAMSTCHDASSRPRSRSRIWGSRVYSILPPLMSSITDPQPRVLRRKPPPAPRSQSDVSPVSRSSPEMPALPSRPPSDASVKTQDMDSPSSLSLRQSSTAPSDVPNFSLSSLDKAQQTPSSTTPSPESRPAKTAIRRNSVAKDHSPRPGRLQKGLSQLRRRSVSLHHQPLIHEPSPDTMPSPVSPVTGIRGRRSFSAQPAAVATPDAPGLCVTPPPSHKPPSRSPKSQSPSRGRIRKSWFPGAGRSRSHSKDAAKRKKSYAWVMSDDPIPAEYNTSFLQKGERVPELWNESGTVLVYLYPRGSGCGPSFKVPEFTTSGSYVFTELIQSDFENVIYGPRNPGQPYNDGARGASPPVSPLSPEPPSCMRLYLPTAPPTASGGHLSAPGEGSDSELDRLIAYRNLFAFLTGQPLVGTKFRPSMFLALLEITDLLQEFAFSGIGEESFGEAVNLSFGFYSDQLGLADCRHSREKTVEALILGERMRNLDLYNEAFAHAAGKYSAIMDLRLPLFRQVSPYTRERLERAHLDLVNRQHNVNEHLEQFEFPSLFAGIANSSSFPELRQVRFKVWRNSFYKMRQFTLGYYKHAFGSWPPKASSKKNPFAESGLNRLVLKALYTDMCALYDLLVDRTRMTTRIIDEVPAISDAADRMTTSALRNILSEFDRSKPPVLPPIPFDLPQLPSMTAIHENFSSLSGKDQNRFERRVKSHELLLILNKAYNYDLQTVKLPFLDQFKDFEMREARGKVNQDLADQRIGYWIFLYVVLQSLPMLVVDAPDLHYTEGVEYFLCQPPMGSPPWVEDKQVRKMWYEVSGGGGRLVELSADAVMFSVEATYHRSHCWVMAQAWEAKDNAAPAPEERAPSPLGPPRRVFTDGGYQYGPHYPPPSSSVSATPSPPPALAAASLRPRNLSPGLDRTHQAWRSSVALGLEPLPMEPPNLFGTHNRSSSVGPRPMSSHVGFRSVSTGNLAAYTRSATPQSTAASTSGATFDDILGSQKTVVKPKKSRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LN26</accession>
    <name>A0A367LN26_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_1700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LN26"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI15853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="59" mass="6817" checksum="5B242915A3D68ED3" modified="2018-11-07" version="1" fragment="single">VTATFAKPSRERSLLHVSLRQCPRRPLRERSRPPLSCSPLPKQAPLLVSRCPLQPRYIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNK1</accession>
    <name>A0A367LNK1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">EngB-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_3322</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNK1"/>
    <dbReference type="STRING" id="1330021.A0A367LNK1"/>
    <dbReference type="OrthoDB" id="391988at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052279">
        <property type="entry name" value="EngB_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030393">
        <property type="entry name" value="G_ENGB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46498">
        <property type="entry name" value="GTP-BINDING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46498:SF1">
        <property type="entry name" value="GTP-BINDING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51706">
        <property type="entry name" value="G_ENGB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EngB-type G" evidence="5">
        <location>
            <begin position="129"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI16015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="358" mass="39223" checksum="69E2F559D63BC002" modified="2018-11-07" version="1">MLAFRRHLLRKASRRTVPVSASFSVSVPGCRGHHVIDADCTAPPTSKVSGLNYGRRRSTIKPILDGLGSDYRSLRDCSIIQQMPGGELTTRISKNQAHALVKAKDFFRGKGCSYLYSAEKFRQHPINEHVPEILVMGASNVGKSTFINALLCRQDACRVSRLPGKTTLMHAFGVGPRPTIPPGLIRKGQAPPRYGLRVIDTPGYGHMSRESWGQGILEYMEKRPAFRGALLLLSSDKQQPTAEDRWMLEMLAERGAKVVIALTKADKYRHSWPSRCADMAKAVSVVLQSQDIPVFVISAAVAAPVNIGNTGGMGGVRIALLETAGFQLRRDGFDLMRDKGLYGGRVVPFDEIQLASSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNS6</accession>
    <name>A0A367LNS6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNS6"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="66" mass="7126" checksum="BD4080F24BE74361" modified="2018-11-07" version="1">MLTLQRQTNTTLPSSIHSHFNPPSAPPLSPYPSTVSGKQAVPRPPFPTATPFFTTSFATTNLLTKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LP17</accession>
    <name>A0A367LP17_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sorting nexin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_1812</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Prevacuolar compartment membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the sorting nexin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LP17"/>
    <dbReference type="STRING" id="1330021.A0A367LP17"/>
    <dbReference type="OrthoDB" id="5227681at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034499">
        <property type="term" value="P:late endosome to Golgi transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07295">
        <property type="entry name" value="PX_Grd19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000030">
        <property type="entry name" value="Sorting nexin-3, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042138">
        <property type="entry name" value="PX_Grd19_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051074">
        <property type="entry name" value="Sorting_Nexin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45963">
        <property type="entry name" value="RE52028P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45963:SF2">
        <property type="entry name" value="RE52028P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PX" evidence="13">
        <location>
            <begin position="35"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI16160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="156" mass="18114" checksum="0CC0BCCDA8398E5C" modified="2018-11-07" version="1">MSDPPKSPTLPRPIMQAMPDTRQQSFDEIYGPPENFLEIEVRNPRTHGVGRSMYTDYEILCRTNIPAFKLRQSCVRRRYSDFEYFRDILERESARVTIPPLPGKVFTNRFSDDVIEGRRAGLEKFLKIVVGHPLLQTGSKVLAAFVQDPNWDRNAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LP76</accession>
    <name>A0A367LP76_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2584</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LP76"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="12"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="64" mass="7352" checksum="925F2F7B75B3F24A" modified="2018-11-07" version="1">MVWTHVAACISQSAKEEQKRRHTILTPHNNDASEKGCPDKQEPRERKVSKVDQMTGMTFVTQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LP83</accession>
    <name>A0A367LP83_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyanate hydratase</fullName>
            <shortName evidence="3">Cyanase</shortName>
            <ecNumber evidence="3">4.2.1.104</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Cyanate hydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="3">Cyanate lyase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">cyn1</name>
        <name evidence="5" type="ORF">L249_1904</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>cyanate + hydrogencarbonate + 3 H(+) = NH4(+) + 2 CO2</text>
            <dbReference type="Rhea" id="RHEA:11120"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29195"/>
            <dbReference type="EC" id="4.2.1.104"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cyanase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.104" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LP83"/>
    <dbReference type="STRING" id="1330021.A0A367LP83"/>
    <dbReference type="OrthoDB" id="10019422at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008824">
        <property type="term" value="F:cyanate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00559">
        <property type="entry name" value="Cyanase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1160.10">
        <property type="entry name" value="Cyanate lyase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00535">
        <property type="entry name" value="Cyanate_hydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008076">
        <property type="entry name" value="Cyanase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003712">
        <property type="entry name" value="Cyanate_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036581">
        <property type="entry name" value="Cyanate_lyase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00673">
        <property type="entry name" value="cynS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34186">
        <property type="entry name" value="CYANATE HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34186:SF2">
        <property type="entry name" value="CYANATE HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02560">
        <property type="entry name" value="Cyanate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001263">
        <property type="entry name" value="Cyanate_hydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01693">
        <property type="entry name" value="CYANASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01116">
        <property type="entry name" value="Cyanate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55234">
        <property type="entry name" value="Cyanase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyanate lyase C-terminal" evidence="4">
        <location>
            <begin position="87"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI16243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="160" mass="17465" checksum="4172C8963C87EC30" modified="2018-11-07" version="1">MSTTPIATLDVPTVPQSTSLLFTAKAKKHLTFSEIAQKLSRSEVATAAIFYGQATATEEDISALSSALDIPRSELAASLPAFPDRGRCVAMPPRDPLIYRLYEVVQNYGYAYKAVMNEKFGDGIMSGVCFSTDVHSETADDGSLWAVITMKGKWLPFSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPM7</accession>
    <name>A0A367LPM7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPM7"/>
    <dbReference type="STRING" id="1330021.A0A367LPM7"/>
    <dbReference type="OrthoDB" id="3595585at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="312"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="504" mass="55902" checksum="3A28D70C75ED0F6F" modified="2018-11-07" version="1">MPALASLADDNDYVRLHITPLDDHLVNIILPASVRPSSRNLSLHTIQAFPEKRYGFVDLPRMDAAKLKRKLNGSLLKGTTVRVQDARPEARTTEPSHDAAPPEKKRKLSSSPGKRDLNVLDGMTLKDRKVKRGWTEAAGAKRRSAKDKDDDARKRTKSRYTNQEECLLKVKVPPKAMGNLPGCKKKGKRPREVTVHEFENTTKFPSFLKSSAPDKDGKMTAEFVEGKGWVDEEGNVVETVRARTARAPETGASVAQTEQDSINSVPSTDDESTSSSSESEDDEQSSAPESTGRRQHQDTSAPAIEEATTDASNPPSSLPGSPRSLTIQIPKRKSESSVHPLEALYKRSDQDADATNKTSQRPPEPFSFFGRGSDDEDATPEAATETGNPANLKPPMTPYSRHDFERRSVRSAAPTPDTAHPSRKNLLWGEEEEEEEEGGEEGEDGGEEEETTREAAASQPGQSDFQTWFWENRRELNRSWMTRRKTAAKEKRHRENKARGPRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQ47</accession>
    <name>A0A367LQ47_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Chromatin modification-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_2255</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Component of an histone acetyltransferase complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The PHD-type zinc finger mediates the binding to H3K4me3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ING family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQ47"/>
    <dbReference type="STRING" id="1330021.A0A367LQ47"/>
    <dbReference type="OrthoDB" id="4173905at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
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        <property type="project" value="UniProtKB-KW"/>
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    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="PHD_ING"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
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        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
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        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
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        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
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        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF42">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="13">
        <location>
            <begin position="626"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="246"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="400"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="372"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="403"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="492"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="523"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="542"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="629"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="631"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="642"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="647"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="653"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="656"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="671"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="674"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="628"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="639"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="643"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="8">
        <location>
            <position position="651"/>
        </location>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI16548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="688" mass="73032" checksum="737475246709FC51" modified="2018-11-07" version="1">MKPTKPASAEGPALRRSQPVRQTRVNPSRYAANAGRDASNAGASASQPITIFPAITHFADTISALPKELVRHFTLLKEVDAKLFAPEEHLAKLVAAAVGAPPPEPRAGLNNTYAVPWGVAVNQADASVSSTDDVPATSGVFDASNIPRRQLFRQTALRIQEMLVSLEEKNHVISTANEALQRQLLRAEDVWPYLEKEFSDEAKWGSSTHWAYPENRLAGKVSHTERARRDGAAAISAAAQALADEAAARSDARKQAVQAKRNQKNQHHDSDADDHHDSRPRAEAGKKAHNSKARKVAEISGGASGATASANGNPPQKRRKVEKTTNGTNGGPYSDRATVGSHAPKAKTSSPRATPVPDLAKKRKALPTASGHAKKKSVHARYRAPRALTHVVLYKPHELTNGASHASPPMASSPVLTTLPEPKGGLRTSPAPGNAPRPASSRARKNSLQSNAEGPKTKSLSSANNKPNGDAAVAQDTAPSALITPRTGGDNKTVKEAEPATKEGERDRIDGGGGGSGPTPGPAKKESKAEEAEPKSEPLPSQPQSAGLVTTKSGRTSKPSTPALANAQELMRPRSSRNTDGGNGNKKQQKRSNTTTTTTTVPHNADEEANSSMHGEDEGDMDADEPTYCHCNSVSYGEMVACDADGCEREWFHLACVGLKVAPGSKTKWYCEDCKERLKMGGKKATSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQA7</accession>
    <name>A0A367LQA7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">fumarate hydratase</fullName>
            <ecNumber evidence="2">4.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_2952</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. In mitochondrion, catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH. In cytoplasm and nucleus, involved in DNA repair in response to DNA damage: following DNA double-strand breaks (DSBs), translocates from the cytosol to the nucleus and promotes DNA repair by catalyzing the dehydration of L-malate to fumarate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.2" evidence="2"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQA7"/>
    <dbReference type="STRING" id="1330021.A0A367LQA7"/>
    <dbReference type="OrthoDB" id="1738025at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004333">
        <property type="term" value="F:fumarate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006106">
        <property type="term" value="P:fumarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01362">
        <property type="entry name" value="Fumarase_classII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000002">
        <property type="entry name" value="Fumarate hydratase class II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.200.10:FF:000001">
        <property type="entry name" value="Fumarate hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.10">
        <property type="entry name" value="Fumarase/aspartase (N-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00743">
        <property type="entry name" value="FumaraseC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005677">
        <property type="entry name" value="Fum_hydII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024083">
        <property type="entry name" value="Fumarase/histidase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018951">
        <property type="entry name" value="Fumarase_C_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00979">
        <property type="entry name" value="fumC_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444">
        <property type="entry name" value="ASPARTATEAMMONIA/ARGININOSUCCINATE/ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11444:SF1">
        <property type="entry name" value="FUMARATE HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10415">
        <property type="entry name" value="FumaraseC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarate lyase N-terminal" evidence="5">
        <location>
            <begin position="35"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarase C C-terminal" evidence="6">
        <location>
            <begin position="434"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00056821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI16591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="493" mass="53333" checksum="880B3399ECD04D16" modified="2018-11-07" version="1">MLRTARKCFFPRGGTTAFISRTMATATRTESDAFGEVEVPADRYWGAQTERSLDNFRINQPQDRMPPPVIRAFGILKGAAATVNMRFGLDANIGRAIQQAAKEVADGKLLDHFPLVVWQTGSGTQSNMNANEVIANRAIELLGGQMGSKKPVHPNDDVNRSASSNDTFPTVMHIAAVLELERELLPALASLRAALQQKVDDFAARNIIKIGRTHLQDATPLTLAQEFSAYVAQLDFGARRVESALPDLRLLAQGGTAVGTGINTFEGFAEAVAAQVSQMTGTEFRTAPNKFEALAAHDAIVQAHGCLNTLAGSLNKIAQDVRYLGSGPRCGLGELMLPENEPGSSIMPGKVNPTQCEALTMICAQVMGNNVATTIGGMNGQFELNVYKPLLIRNLLHSSRLLADGMRSFEKNLVKGLRANEEKIGSIMRESLMLVTCLNPKIGYDMASKVAKNAHNKGLTLKQSALELKALTEEEFDELVKPELMIGPKRYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQS9</accession>
    <name>A0A367LQS9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">DNA repair protein Rhp26/Rad26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_3314</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQS9"/>
    <dbReference type="STRING" id="1330021.A0A367LQS9"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22254">
        <property type="entry name" value="CSB_WHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18000">
        <property type="entry name" value="DEXHc_ERCC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000094">
        <property type="entry name" value="DNA excision repair protein ERCC-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="408"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="731"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="213"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="348"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1003"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="76"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="264"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="301"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="358"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI16582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1143" mass="128593" checksum="79440B604FCEF333" modified="2018-11-07" version="1">MASDQNEAGRESSQSRESILNMVVAAAQGASSSEMETRKSPTIGMSEEDALKNLTGAVRDQDDLERDITMKANTVLMEAEDNKDKKRIEKLEITKQRLQLQLEEEKRKLQRVSGNPYQSRKLQVEISKLDDEIRLLNNDISDFEARIDKRHREDPLENANLTKSKRLPGEGHREYLIRTGKITPFTKVGGPRPPDLQGQLADTILDAEEECAADGLNAEAEGPKSHQSLRRPGFDDETETHASGAPPPVVESEFSLRPRKRRRVQADRRSSAKPDDEQSSGSEYLEKTAIWQQGTEDDLIREERRKSKAKAEAGDHEEIDLSKIDDGNEAYYQKRLADWISRRSRARRARRHAKNPDGPEEDSEAEEPEWYKPSPDYPDHHVSDDLKLPGDIHPSLFGYQKTGVQWLAELYKQSVGGIIGDEMGLGKTVQLIAFIAALHCSKRLKHPVIVVAPATLLRQWVSEFHRWWPPLRVAILHASGSGMLNPRMEDEYSVGRRSLGAARRIVKGVVDKGHVLVTTYTGLQTYADELLPVQWEYAVLDEGHKIRNPNAEITVACKELNTPNRVILSGTPVQNNLTELWSLFDFIYPMRLGTLVNFRSQFEIPIRQGGYANASNLQVMTAEKCAEALKETISEYLLQRLKIDVAADLPEKTEQVLFCKLTDGQRDAYETFLKSDEVSAILSKRRQSLYGIDILRKICNHPDLLDKSLSDKAGYDFGSPKLSAKLQLTKDLLQKVMIPNGHKMLLFSQGKQMLNIIEKCIKKCGITYLRMDGETPVDQRQSMIDKFNTDPLIHVFLMTTRTGGLGTNLTGADRIIIFDPDWNPSTDLQARERAWRLGQNKPVKIYRLMTEGTIEEKIYHRQIFKQFMTNKVLKDPKQRSSYDLSDLYDLFSYNPGKDAALERSDVFKGAEVNLANAADGLAVPEPDAEQRELRHMKMVATMEDYREDKSIHDEKRMLEGIFARSVNSAYDHEQIVNGPQKAKADQGVLRQEANEVARQAAAHLRRSADDARRMPIGTVTWTGEVGSGGRAGASRRRGGPSSAAIMSNLAERQGLDEGSGSSSRSGTPSIDKKLKSKDFAAMIKTFIERHGGRVPSKMLVDHFNPYCPGKRQSDEFKTALDRVAVLHKIGGSGRGIWTLKPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LR10</accession>
    <name>A0A367LR10_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cell wall protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_1774</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LR10"/>
    <dbReference type="STRING" id="1330021.A0A367LR10"/>
    <dbReference type="OrthoDB" id="2422134at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021054">
        <property type="entry name" value="Cell_wall_mannoprotein_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38123">
        <property type="entry name" value="CELL WALL SERINE-THREONINE-RICH GALACTOMANNOPROTEIN MP1 (AFU_ORTHOLOGUE AFUA_4G03240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38123:SF6">
        <property type="entry name" value="CELL WALL SERINE-THREONINE-RICH GALACTOMANNOPROTEIN MP1 (AFU_ORTHOLOGUE AFUA_4G03240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12296">
        <property type="entry name" value="HsbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016776723" description="Cell wall protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="178"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI16859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="27704" checksum="09056B4526043BAB" modified="2018-11-07" version="1">MKCNALILACLASGALAGIEEIKQAVGNCGKGIEALDSSLKGFSGNPQPIKDAAAKLVSILKESKAVAEKSDKLSLSDALGLQEPVQGLQASSKELVSHLKLGKPMIEKGGYCKLVRENLGEVNSGSLAFMKAVVEKVPTDAQPIADKLAAPLKQNLEEAAKEFSESNCKDSSGGGSSSAPASSSSAPASSEPASSSAPASSSKESAAPTSSEEAEPSSPASSGYKMPSAPATTPYQPTGTGYPTGSKTTQPPMVTAGAAALAGPAGVLAMAAAALVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LR31</accession>
    <name>A0A367LR31_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LR31"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="233" mass="24054" checksum="EF244EDAB72475A9" modified="2018-11-07" version="1">MPLALSEQGGSGSSSRSDSSRSSSRSNAQPRGEGGRASLLPAIGGKEGGKRAKLAQKAAAAAALIAATAGTNDFARNEAERLANAAANSDDDYYANAAAEVDNYANGAADADRAEAVAAAATAAANAAAAREAKKAVFTAATRAKRREEARRAAEKAAAPALARAALAALDKELAVAEDKEEEDEDVDNNDDYNNKLAPRAEETKKTEKKKAVGAVRAYPCVRCVSQQQECRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRL3</accession>
    <name>A0A367LRL3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_2045</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRL3"/>
    <dbReference type="OrthoDB" id="5283415at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="50"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI16872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="366" mass="40492" checksum="8A730F0FF71E762E" modified="2018-11-07" version="1">MTDPRIEEAIATGKVPQHITAEYLGRSKDSEGVGWIVFITLLVNVVVISRLSSRAWVVKRLGLDDGLALISLIIFIPFAIVCTEMIRLGSGRPFTFRSLILPDKQFDMTQTLDTISQILYATALMTCRASGLAFYHRICALYNEFLIIIKFIFCIIFLGYLAQMSLIIFHCLPVTTLWGPSPKKDFRCISWLEVQTVTATISFLCDLLVFGIPLAMLRVLKSMDRKRKIQLSCIFFPGIMGTDDYFIYAFLSLLVVEVSEIGISLIAISLPGLRPLLYKFVLRKSPEGANSPPPHRSSSFATPPVSKAPRLSVQSVDKAGPGFQVRTITSVVSPRSPVNKEGATQAGISVTSEFKVEELEAGKKAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRP3</accession>
    <name>A0A367LRP3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF2293 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_3256</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRP3"/>
    <dbReference type="OrthoDB" id="5288828at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018744">
        <property type="entry name" value="DUF2293"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38113">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38113:SF1">
        <property type="entry name" value="DUF2293 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10056">
        <property type="entry name" value="DUF2293"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF2293" evidence="2">
        <location>
            <begin position="192"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI17114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="710" mass="79526" checksum="0DB334A2AC52A9DF" modified="2018-11-07" version="1">MGNCKRKQPGALKHKSKSKRANRPLPEGDIFVPRDVVARRPLPVVKSKHRSYFELVQNADKKKKLEFQNTLNPNPPQGFEFVPVGNPELTSACKELSRDRGLKIYIVAVRHDITNRFLPHETYSHEKSHEEAHAHSLATQMNRVGYHFHANVVREAKASIHHVTEQLFTVPGIPEPIPECQSLYYTQADAVLRDLFPRVPNTDRQSIILHSFTEGALYNGGTPVGRNPTLTLSRRVQLAVLAHIRHAHTLYDDLLRRMPWHDARKAVQPVCLDTLVKWRGDEESGRDQLDEILREVVVISDSEDEDAMEDSTDDTSVISSTPTPSDGRNVHRRLPVPDRGTANVTGGGRNDRRGFERYRRAWDDAVRRNGETRHDAAGSFHDGDGAALPGAPETRMAHDASGNAPAPNGYVPPGLQVYRAGPRMIATNDDYQEVNAYARDGLRLPLLPSASSNPDMLVHPAAGVEQPSYRPRAYPSLGTGPDRPLVYENRSMQYYFGSSPSPARPPRESWRTDGHVHRGELRPMSPVQMSGCHRDRYGMPSNPAQVQSTQPAAERIVMNSARPGSRSNTVVMEDRGGFYERIADHPEDAGLQPRSDGVPRSSVAMHAPERTRSGPHGEPASYRSPSPLIIPRVEAAGGTVAPSWRVDRRPGFVSHMKEDHRPQEELRFQQVRSGDAHYRHHQQPRQDVDDDCIFIRQRPTLAANHIDLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LSE6</accession>
    <name>A0A367LSE6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin fusion degradation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_2405</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UFD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LSE6"/>
    <dbReference type="STRING" id="1330021.A0A367LSE6"/>
    <dbReference type="OrthoDB" id="422728at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.50">
        <property type="entry name" value="Ubiquitin fusion degradation protein UFD1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004854">
        <property type="entry name" value="Ufd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042299">
        <property type="entry name" value="Ufd1-like_Nn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055417">
        <property type="entry name" value="UFD1_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055418">
        <property type="entry name" value="UFD1_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555">
        <property type="entry name" value="UBIQUITIN FUSION DEGRADATON PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555:SF13">
        <property type="entry name" value="UBIQUITIN RECOGNITION FACTOR IN ER-ASSOCIATED DEGRADATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03152">
        <property type="entry name" value="UFD1_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24842">
        <property type="entry name" value="UFD1_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 1" evidence="4">
        <location>
            <begin position="32"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 2" evidence="5">
        <location>
            <begin position="132"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="257"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="319"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="272"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="319"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="343"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI17363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="371" mass="40731" checksum="A1FB9E5BD3357F7F" modified="2018-11-07" version="1">MYSGFGGGYDASNPEHLYNLARHGRRNMMQRFDEYYRCYPVIMAPGAERPELNYGSKVILPPSALDKVSKLHVQWPLLMEMINGEKGKHSHAGVLEFIAEEGRAYIPQWMLETLGMDVGDMIQIRTTSLELAKMVKLQPQSVSFLEISDPRAVLEMAFRNFAALTKGDVFNFEYNDEIFQVAVLDVKPETEKMGVSMIETDVSVEFAPPLGYVEPERKSGTSTPRSGVAAGGVVNGKGTMAQAINYDAMAPSAATSFRGEGQRLTKKGGKGTATAVPAAESAASNQSTTGMATAPLRLPPNKLFFGYEIKPVKTFEDKIKEREEAERPHFAGRGQNLRGTAKRKGEGDEQSKAPDKKGTGEEGRRLDGRQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LSH5</accession>
    <name>A0A367LSH5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HORMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_2892</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LSH5"/>
    <dbReference type="STRING" id="1330021.A0A367LSH5"/>
    <dbReference type="OrthoDB" id="21254at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016035">
        <property type="term" value="C:zeta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045091">
        <property type="entry name" value="Mad2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842:SF10">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="2">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI17404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="160" mass="17392" checksum="17C97E69C91AE0B6" modified="2018-11-07" version="1">MAYSQAVHQSRHPAVCAWVRDAVDAAEASIRQGAVARIALSIHRPADGDVVERWVFDLDRGFPLAFDSSLLDHQHQRRHYDDDDDDDASVAAAAATTIPAPPLNTSDLHQSWRAALQRLAIVASSLPPTPENCTFAIALELRTDAAPPTTQHHPPALDPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZ28</accession>
    <name>A0A367KZ28_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3778</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000029">
        <property type="protein sequence ID" value="RCI07433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZ28"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI07433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="71" mass="7762" checksum="7403A5353A3DE4A0" modified="2018-11-07" version="1">MKPLGQGRKTHQPVPPEKDAPASTTVASSAMQSIGLCPEVNAHFEATPRRASLRYHITFIDNDSIISIIYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZ40</accession>
    <name>A0A367KZ40_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calcineurin subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Calcineurin regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Protein phosphatase 2B regulatory subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_4560</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Composed of a catalytic subunit (A) and a regulatory subunit (B).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the calcineurin regulatory subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000028">
        <property type="protein sequence ID" value="RCI07441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZ40"/>
    <dbReference type="STRING" id="1330021.A0A367KZ40"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050801">
        <property type="term" value="P:monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000047">
        <property type="entry name" value="Calcineurin subunit B type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45942">
        <property type="entry name" value="PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="21"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="60"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="90"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="131"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI07441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="174" mass="19724" checksum="05F21D84AB7F95EA" modified="2018-11-07" version="1">MGNTTSAVLDNIVQGSNFDREEVDRLRKRFMKLDKDNSGTIERDEFLSLPQISSNPLATRMIAIFDEDGGGDVDFQEFVSGLSAFSSKGNKEQKLQFAFKVYDIDRDGYISNGELFIVLKMMVGNNLKDQQLQQIVDKTIMEADLDKDGKISFEEFTKMVENTDVSMSMTLDQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZ87</accession>
    <name>A0A367KZ87_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ribonucleases P/MRP subunit Pop8-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000028">
        <property type="protein sequence ID" value="RCI07484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZ87"/>
    <dbReference type="STRING" id="1330021.A0A367KZ87"/>
    <dbReference type="OrthoDB" id="5530243at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000171">
        <property type="term" value="F:ribonuclease MRP activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034965">
        <property type="term" value="P:intronic box C/D snoRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000294">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, RNase MRP-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020347">
        <property type="entry name" value="Pop8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049128">
        <property type="entry name" value="Pop8-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28173">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28173:SF1">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20976">
        <property type="entry name" value="Pop8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribonucleases P/MRP subunit Pop8-like" evidence="1">
        <location>
            <begin position="23"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI07484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="142" mass="15289" checksum="779580EC9A60DB8B" modified="2018-11-07" version="1">MASSRPQNPPCGNTLSCTVRSPPFAYAYLQLATDDNKDDGAVDLDYLQVKSYCDAALRQFLGLAGAAIPVEILSVNGRQCWVRVPGPDLGTFGAAITAWQGVTESGSRRLLRIRRCSDWLGVMVGADGQERLWTDGGPDSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZN8</accession>
    <name>A0A367KZN8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">REM-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_1633</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RICTOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000026">
        <property type="protein sequence ID" value="RCI07640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367KZN8"/>
    <dbReference type="OrthoDB" id="271111at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031932">
        <property type="term" value="C:TORC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038203">
        <property type="term" value="P:TORC2 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01169">
        <property type="entry name" value="HMPP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19367">
        <property type="entry name" value="TenA_C_ScTHI20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.160">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004399">
        <property type="entry name" value="HMP/HMP-P_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011072">
        <property type="entry name" value="HR1_rho-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036274">
        <property type="entry name" value="HR1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028268">
        <property type="entry name" value="Pianissimo_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028267">
        <property type="entry name" value="Pianissimo_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029453">
        <property type="entry name" value="Rictor_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029451">
        <property type="entry name" value="RICTOR_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029452">
        <property type="entry name" value="RICTOR_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004305">
        <property type="entry name" value="Thiaminase-2/PQQC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13298">
        <property type="entry name" value="CYTOSOLIC REGULATOR PIANISSIMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13298:SF11">
        <property type="entry name" value="RAPAMYCIN-INSENSITIVE COMPANION OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02185">
        <property type="entry name" value="HR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14663">
        <property type="entry name" value="RasGEF_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14666">
        <property type="entry name" value="RICTOR_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14664">
        <property type="entry name" value="RICTOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14668">
        <property type="entry name" value="RICTOR_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03070">
        <property type="entry name" value="TENA_THI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00742">
        <property type="entry name" value="Hr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01303">
        <property type="entry name" value="RasGEF_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01307">
        <property type="entry name" value="RICTOR_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01308">
        <property type="entry name" value="RICTOR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01310">
        <property type="entry name" value="RICTOR_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46585">
        <property type="entry name" value="HR1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="REM-1" evidence="3">
        <location>
            <begin position="106"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR N-terminal" evidence="5">
        <location>
            <begin position="239"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR middle" evidence="4">
        <location>
            <begin position="694"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="domain" description="Rapamycin-insensitive companion of mTOR" evidence="6">
        <location>
            <begin position="1102"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="134"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1215"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1324"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="139"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="157"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1215"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1226"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1347"/>
            <end position="1356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI07640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1754" mass="193328" checksum="29DC9AF4F09590EA" modified="2018-11-07" version="1">MIMPPSSSQQNSLHHQQQPGRISLDRDGGALQPPNGGSSRKLSASTISFAPRGSSLNPSAGLGSFSSDLRSQTISSRAGSRAEVGSVYPGSFTDKVEEDDAAAAEQALAVLKDKLNREMKIKEGSENMLEALNIKKAKQTKDQRQRVEAELSASNSRIKELRQKISDAQRPKVAPPTTPTRSRNQDGLLQSNGLLRSPPSISRSAIGSDIDEMLESPTFLLAELLQALEVEAMSPEYYVSRANQLVELFKRHPAIKYDLVWSIFGRRMQMMLLSESREVVAAGYRTTRYAITDVASLKKIRSLNVDYLVIRSLNNYRKADVEREQALKFVRAFLDVKDGVREVSRAVVRTIVAVAEQSEDRRPGVQVTDHNVDRLRPICIETLAEIMIQDPRLLIASGGLGPLCDALAEGAYKAPESLVSAFLFLLDTPGRRGYMQPGYGLEVVFTAFTDQLASAESILKQNSRAISVAMKSWSGLMALCMYDFRPIRSLIASILFPSPAIRETVLDLFFSLLRIKSPAWATSFLAGRRLTTYGRVANMKSASGRERSGTLSHEEDTGEQNFVDHYTALLLAVFIKAGLLQSLLRVAQSEEEQTLKRKTTLLIGEVLKLASRLLPPSWSAELQLLPELFAAAAQFGNDAHFVASGIVYQISSVSRTLYRSAPSESMAGALPSSDSMQNLVMMEEHPKASTAVAFDDATFRQLLIDTGVLNSSNYLKWNWDVIVKVIDGPLQIGKRLEEAIKASKFMKRIMSFYRPFKYKFADIRSTRNTHKYVKAGCALVHSLLQSPEGIRVLADSKLLRQIAECLAHGLTAQFPMFAKDRLTDTLCGGYFPMLGVLSSDANGLLLLERWRMFNMMYHIIDLKQRPDLIKLLLSNFDYSLKGHPRVLLSKALVAGTKEIRIHATNTLRKCTMRPVSSLGGRGNASDAKWAIQLLVTQLYDPEIEVCSTAVKILENACNRKTFLECIVECRPALDHLGEIGAPLLLRFLSTSIGYHYLDGLDYISNEMDDWFLGRNDSYVDVIEASLARAFLASPDDHGHRGSLFDEAEAETDYHDSHVPPHFYRELTRTREGCKLLSDKGHFEEFVTTIRDHGMQTEDGELMTKVKGCLWAVGNVGSMELGAPFLESSDVVEQIVRLAESHEVMSLRGTAFFVLGLISRSTHGLEMLSEHGWDANTTPMGASLGLCMPNDLSKLFSLKPWKHVKAASIQLPDTQRTVREQPEVRPARPPLAPSEMPPVLGDADVNERIMELIVDLGNMVLYKKALTDLQRLRQRKPKAFRSVDFFKKVMGLMEWNHYRLGVRRLVIDLFEKNVMRQIVFGGSGGEGEGVAARGHAEATDDGEDSSEGDDRTERQRSISEPADIPVLLVAGSDCSGGAGLEAGQKVLAAQGCYAMTATTALTVQDTKGVHGIHVVPAEFVQRQMDACLKDVGADVVVTGMLATADTVEAVSRQVANHGVVVSTSGAQLLPHDAVRSLVKYILPQATVLTPNLPEAELLLEEANKHLRDEDVVAPCRAVQSLEDFEALGRRLQALGPTWVLVKGGHMPLGADLKAASTAAERAVVMDALCGPDGYFLPLQSPWQESTSTHGTGCSLAAAIASGLARGLDANLLSAYALRETRLHVNFCASFDISLSEMEATEEHQACTAYTRYVLDVGHAQDLLALHMALAPCMLGYAAAARMLRDHPDTRLDGNPYREWIRNYTGDDSSGAVERCSRQLEDMMLSQSPSRVEELIGIFIHATKMELGFWNMFPYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZP5</accession>
    <name>A0A367KZP5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_1636</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000026">
        <property type="protein sequence ID" value="RCI07645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZP5"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI07645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="158" mass="17539" checksum="F13E98F9BF7EC13E" modified="2018-11-07" version="1" fragment="single">PKLSEILSHMSGIAVPHRPSWTRLTKHQKATVMVLEAETDGRISQHIVQLLRHVSLSSPLAPWRNKPYRGDLGQLGILLAEEPPNNRVIAAGGLDVALVVDDGQQIADVVALVEKGPQLRVVPRRLSLCRRAHHPLTVANGTLRLIRRRRRVGRVAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZV9</accession>
    <name>A0A367KZV9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-lactamase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_5679</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000024">
        <property type="protein sequence ID" value="RCI07687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZV9"/>
    <dbReference type="STRING" id="1330021.A0A367KZV9"/>
    <dbReference type="OrthoDB" id="5946976at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.600">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050491">
        <property type="entry name" value="AmpC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021860">
        <property type="entry name" value="Peptidase_S12_Pab87-rel_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825:SF9">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825">
        <property type="entry name" value="D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11954">
        <property type="entry name" value="DUF3471"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="86"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S12 Pab87-related C-terminal" evidence="4">
        <location>
            <begin position="519"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="453"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="463"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="480"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI07687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="623" mass="69062" checksum="48C159E440F0E96C" modified="2018-11-07" version="1">MRRFRRPWPVIGPRRGARSRWAEPDYPPGRRVTITTTSPAYSDAASIIIIIIRGLSHSKTKTQTKTKKKRSKTPAAIMDVVRSPDFAAYVKRLMERFHVPGLAVAVAKGQDEVASAGFGKASLDPDVDCTADTLFDMASASKSLTAASVALLIADEGHPDVQWEAPMEKLLPDDFVMPGGDHSDVTVEDILSHRTGMPSHDNSYLGRSAAQPDDPRSITRNLRNLDVVAPNRSGYIYCNMMYTVASYLVERVSGLPFYDYLDQRLLQPLGMESTCLQLGRARTKGLGDRIAKGYVWDEAAGKYDEVPCDDDAPEAQGAGCILSSVNDYIKWVQAMMNRSGPITEDVYEGLVKRRIRQSDDDVPDDVIDEAAEAASGTSSRSATPPPPPLYYAAGWEVRDYCGYTIVSHDGSEDGFRTNHFFVPQLKFGGVVVGNSDGAADVVSELTHRLIDEAVDGPDAGTNLLESLSESDSGSDSGSASDEEEEEGEGEEGEKKTNKKRIRRGPAAELREEMCPGIREPQPQTVPLSAYTGRYWNEGYREMVVDEKEGELVVDATKRSMGFHLRLEHVSDQTKYLAYLRERFDKEGSPLKAEFRLKGDKAVKMGLWLEERMKDYIWFDRIDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0B8</accession>
    <name>A0A367L0B8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5871</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000023">
        <property type="protein sequence ID" value="RCI07875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0B8"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI07875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="314" mass="34635" checksum="9949F55738560559" modified="2018-11-07" version="1">MSRNGFRVDTTGEVEAARELADAAFCKPIFGLVLRLHLLLHGLALISALVIAGVGVVVFLRLILDGSLMKRVTRRRRLALLFGDGPSLAPVLEMTGRPGPLDTATDEHRLRIGKLNANLILVHPRKFAVKLIVLSRLAHVELWLPAGETFAATTTSLLRRLTRVVVKVIQKAEERGEGRGVRVVEVAREEGHESSIKPFIYTQKGSSIEPSATSEKQIDDSGNDTKHVFHFCRPWKPLDFFAQRDASVVKLRTKPHRQISQPALSRQLSSSCHLVLPGASPSLDNMPHHLLDSNLGTTHITNPPPRHHNAISIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0M4</accession>
    <name>A0A367L0M4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000022">
        <property type="protein sequence ID" value="RCI07966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0M4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI07966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="149" mass="16631" checksum="967265B7AE8E9F63" modified="2018-11-07" version="1">MSKYDIHVENECMRHVKSTAQLVAGLSVRYQSSCSGEYGTAPSVDIKKAFFFFRVERAKTCFFLFACDAVTVESKAGERDTDDSRGVAVLTATICEGQAEMGSDGTQDDMRKRKTRSNRLRDPPERPAPTARPYGSSARPVWSLHRARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0P0</accession>
    <name>A0A367L0P0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">HIG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_7813</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Cytochrome c oxidase subunit which plays a role in assembly of respiratory supercomplexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Associates with the respiratory chain complex III/complex IV supercomplex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RCF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000022">
        <property type="protein sequence ID" value="RCI07984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0P0"/>
    <dbReference type="STRING" id="1330021.A0A367L0P0"/>
    <dbReference type="OrthoDB" id="6604018at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097250">
        <property type="term" value="P:mitochondrial respirasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050355">
        <property type="entry name" value="RCF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297:SF3">
        <property type="entry name" value="HIG1 DOMAIN FAMILY MEMBER 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12297">
        <property type="entry name" value="HYPOXIA-INDUCBILE GENE 1 HIG1 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="11">
        <location>
            <begin position="13"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="136"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI07984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="218" mass="24347" checksum="3D6AE6405EFDB1B6" modified="2018-11-07" version="1">MADRPPPPLPGSMPSSFDSDPDFHKERRMNKFVRKLKEEPLIPLGLGLTVFAFVNAYRAIRRGDSHQANRFFRLRVAAQGFTVLAVVGGGVFYSNDREKVKELRQLEAQRAAEEKRQKWLRELEARDEEEKALIASMAQKKLPQNSSEEQPSGGLLRKMGLWPQGDGSKAAVNEDTSASETRPKKENPKSSLGVIGEVMAAKKREQSESKTEGGKKDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L130</accession>
    <name>A0A367L130_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_6292</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L130"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016647462" description="Secreted protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI08121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="82" mass="9308" checksum="A9F296D15DBE2FBD" modified="2018-11-07" version="1">MIMALASLSVVLSAAHFGYCYKEEERSYRLLPPSSSSLTPRHHHHHHHHHHYLVPIQGSGCEPSHSVRARAMAASQRGRHRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L134</accession>
    <name>A0A367L134_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_6297</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L134"/>
    <dbReference type="STRING" id="1330021.A0A367L134"/>
    <dbReference type="OrthoDB" id="4065319at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051009">
        <property type="entry name" value="PRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36089">
        <property type="entry name" value="CHITIN SYNTHASE 3 COMPLEX PROTEIN CSI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36089:SF1">
        <property type="entry name" value="CHITIN SYNTHASE 3 COMPLEX PROTEIN CSI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016579613" evidence="3">
        <location>
            <begin position="31"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="44"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI08126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="354" mass="36857" checksum="823A7A05CA31A97B" modified="2018-11-07" version="1">MPRLLLPPDSQSLLLSTLVLFAPIPRPAMAQRAAISSPGRGDAEAPSPSSSSDESTPTPSSSSSSSDEATTTASSQRSTANPTITRGPSATTGHELTGFPTLTRSAIPTYPPPSVPPTHDAPFMHHSTLPDGTVFIAVGAILGAFGVAILLYRAIVSLLLHRSVKRAAMAQHLSKSKTSFPAPPAPFYKYTDQESSMSLAAGRGVRRTNRGPIPSATPSHSNLFFSPTAVNNASASRASTLLPSGFYGAGASPGLHANSISLHNLRPDSRGHYTNGSRQTLTGTPPDSPQYHPRRDGNITSASSLHINTGSSSARRAPSAYLEDLLADDAVSLAPQPVPPSELPANSLHPDGRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L175</accession>
    <name>A0A367L175_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 19</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 19</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MED19</name>
        <name evidence="11" type="ORF">L249_6264</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L175"/>
    <dbReference type="STRING" id="1330021.A0A367L175"/>
    <dbReference type="OrthoDB" id="2160599at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013942">
        <property type="entry name" value="Mediator_Med19_fun"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08633">
        <property type="entry name" value="Rox3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="68"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="259"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="351"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI08166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="372" mass="39027" checksum="39EA821A65975234" modified="2018-11-07" version="1">MSVHPQTPQSPCRFSPATSSDSVMGLAVASAASASASAAAAASAAAAAGSTTSSSCSLATLPTPAHSVNGANSQLDLGLVDSPHKRKRTLDDGGSGRDRKKMHRDDDDDDDDRMGIEDLHLDVGRKYLLCQNTYPESLPPTSEDLYQMFGLTALAAEVAREKPNGEKNALRKTYKGHIKRLGVAGHFDVQKKNEDAPSDFLAMLAVPELEWNVHQVKGRDICQGLSEATLSNLGRAVTLSRGSLSKSVWDSSVLGDLAPAASDGSKPQSAKATAPSTPLASTPNAMGRSKAQLPVGAGDVARPRRNNKKRSYGDSSFEGYGEGYPDDDAGVDTGYSTGEGDGGQKRRKKNPSNSPTYSAMRQQSYGPGMVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1I9</accession>
    <name>A0A367L1I9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_8361</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000020">
        <property type="protein sequence ID" value="RCI08278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1I9"/>
    <dbReference type="STRING" id="1330021.A0A367L1I9"/>
    <dbReference type="OrthoDB" id="4930473at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI08278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="122" mass="14090" checksum="117C95ADB3DB0019" modified="2018-11-07" version="1" fragment="single">TRCKDIRTFSRKKGKFSAFLTNLKDKIRTDKATFRDKEDRIGFLFRSLKGKARKTLETYLLTKTKDDSLSYEDFCDYVKDAAVKRLDAKLVLPNDLPALAKYSLSILLPRTPLLNRQIDLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1N8</accession>
    <name>A0A367L1N8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_8874</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1N8"/>
    <dbReference type="STRING" id="1330021.A0A367L1N8"/>
    <dbReference type="OrthoDB" id="14252at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015227">
        <property type="term" value="F:O-acyl-L-carnitine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902603">
        <property type="term" value="P:carnitine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006839">
        <property type="term" value="P:mitochondrial transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF4">
        <property type="entry name" value="CONGESTED-LIKE TRACHEA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="19"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="118"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="232"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI08335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="33492" checksum="D17DFBA6663F1FF2" modified="2018-11-07" version="1">MSADGESASKAKKVPSKLRSQAQALAAGGFGGVCAVVVGHPFDLVKVRLQTSSRGTYNGAMDVVRRSVARDGLRRGLYAGVSAPLVGVTPMFAVSFWGYDLGKQIVSSLSPTTASTSLSIGQTATAGFLSAIPMTAITAPFERKTTTTTTTTTTTAPKHHHRNAADVVRHLYKTGGLRSVFRGSAATLARDGPGSAAYFAAYEYIKASLSRPSPSPSSSSSSSSQQQQQQPLSLGAITCAGAAAGVAMWIPVFPVDTVKSRLQTAEADVSISSVVRSLYAQGGFRAFFPGFGPALARAVPANAATFLGVELAHQAMNRMFGPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1W4</accession>
    <name>A0A367L1W4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_6363</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1W4"/>
    <dbReference type="STRING" id="1330021.A0A367L1W4"/>
    <dbReference type="OrthoDB" id="5106181at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI08212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="292" mass="33141" checksum="FE323E025801ADC5" modified="2018-11-07" version="1" fragment="single">TSRFPTASISLTRVRKFESNFIADYESNIILLNEDRQSGDDPVPPVNIPDPIPNIPEIEGECGVKICALNYDLASKRKGKLRVINDLRALNSIAVLDAYLMLIPQDIIYKLAGKKIILAINARNYREQFTIISYRGLERATIALIGRSDSSDRCDTLFPASHNGSNYYRNAKHLYSVKDENPMPPLLEEKDAFYDIINALCSNAALICYIPGAFNILADLLSRLPLKAAPEKGDRELEDIWEDNINTDYVLIALLFLEDADGRKRLCIPENCADELISEYYLRKFYTSRRRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1Y9</accession>
    <name>A0A367L1Y9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1Y9"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="89" mass="10274" checksum="83793F6C2ABE4CAA" modified="2018-11-07" version="1" fragment="single">EEKKKKPVVAGGKGKGRRDRGRKRGRAGYRKLSRGRKNDEGESRSRSDQPRPEWGRRMDGRTHNMSRDKQNLTPHSHLHHSSRVPLLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L220</accession>
    <name>A0A367L220_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_8852</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat AIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L220"/>
    <dbReference type="STRING" id="1330021.A0A367L220"/>
    <dbReference type="OrthoDB" id="2306at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000102">
        <property type="entry name" value="Actin-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000167">
        <property type="entry name" value="Actin-interacting protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19856:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19856">
        <property type="entry name" value="WD-REPEATCONTAINING PROTEIN WDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50960">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="58"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="189"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="233"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="327"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="537"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="582"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI08471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="618" mass="64100" checksum="8DC6C3C146A43170" modified="2018-11-07" version="1">MAAAPSISNVRILAAAPATTRGQPTQLSADAKGQRIAYASGKSIFVRSIDDPSDCREYTGHAAPTTVARFAPNGVKVASGDTSGVLRVWEPEALASGSGKEYGIVAGRLNDIGWDGDSQRLIAVGDGKEHFGRCITADSGNSVGEIIGHSKSVNAVAMRLQRPLRAATVGDDGNVVFYHGAPYKFNDKTALHRGFVLGAAYSPDGEAFVTVGADKRIQLYDGKTGQPTATVGDGEHTGSIFAVSWSADSASFATASADQTVRLWDAKAHSLIQAWRLGGDAAGSNVLHQQVGIVIPPGRSDGLIISLNLAGELTYLVRGKPDPVRVLQGHNKAVTAMTPATDGRGSALWTGSFDGRVCHWDLDAGVGAVVDGEPHTNQIAQLTGLPGSVYSAGWDDTLRIVDEASCAFRGESIRLPSQPKGVGASSDGLVYVATVSGVAAYSGDGKPLKETALGYAPTAVAASGKHLAVGADNNSVRIYAADGAGGLDEVKAVPNPSGTVSALAFSRDGSHLAAGNSIGKIYVYQAAGDWELVADRWSAHTARVTCIAWDESGAYAASGSLDTNIFVWCLEKKHQGKRIKAANAHKDGVSGICWVKGGRVASSGGDATVKLWEVRDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2J4</accession>
    <name>A0A367L2J4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_4799</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2J4"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DUF676" evidence="4">
        <location>
            <begin position="146"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="451"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="407"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI08651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="989" mass="111917" checksum="30624F386DDF225B" modified="2018-11-07" version="1">MASKWTKTVFRLSKIPSSITVYHELAVLLASATDRFPASSITVYSLATTLVPWENPPTKVATLMFKETPPFLASATPDEAEWQLPITFLDEAHVLVLDHHFWGMTPLNDVAGESPSADCIAISGLAGHAFGSWAPRGEDRTFMWIRDQVPKEVPGARAILYGYKASLLNSDSFQGIEDLAIGLIAQMKAHGLDESSQPLIFIAHSLGGIVLKSAVRKLANAEDNFSERRLFSRLKGAIMFGVPNLGMEHNHLLTLIQDKYVKNIVHDLSILSGKSGYLYALEKSVSGIAEMRQLRFFWAYETDVSPILDVSLPHDDPIRSQTKKMTGPPVVLVDPGSATAYRVTDDKKQKTVTPVTGDHSTIVKFTRSDHRVRPIIHELRNYCGLPRELESNHSSFPLPVRRPITSRGRDESPPANVRKSEYDQFQELIASLFSPELHLRQQAIADRFKFTCEWILENEHFVSWLRRDEGVFWINGKPGSGKSTLMKFLLQHPGVHDYGHDFSSQVTRITANFFFNFRGTSLQKSLHGLLQTVLHRVLGALQSSDNAKPIIDHLLATLPKSTPGRTWWTRERMEQALRTVLNQKLAPVSITLFIDALDEFDGTPEHILHFLNYLTRRPPASLTRTKLCFSSRPWDIFTEAFGKRPNLAVQDFTENDIRYYCTSTLASALSNKSFIKPLADEIARRASGVFLWVTLVTKELANESSNATSLEPLLELVDGLPTELENFYNLIIQRIPGNERLRTYALLEALIRAHNSEEFGIKHLYKTTLISHCQTYGECREALLRARFSDTDEVLVQARKKMLYWSGGLVSVGADAKVQLIHQTAYEFVVKLDFRDRLLAEVSRTVSENGHAFHFKTILLAEGDKGYGPPLSITRLIELPLVDYSHGYMAEQTTGQRWWTFLNSLPRKQFDHLNQRLEIRFERYQKGFSKDAFKIFSPIGLAVSFGLRLYLEDLVDQAPEPFASAECPDFLLHLIAVQFDTMYQENPHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L313</accession>
    <name>A0A367L313_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_4677</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the peptidase C12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="8"/>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L313"/>
    <dbReference type="STRING" id="1330021.A0A367L313"/>
    <dbReference type="OrthoDB" id="427186at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09616">
        <property type="entry name" value="Peptidase_C12_UCH_L1_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.532.10:FF:000008">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF17">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 8" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="10">
        <location>
            <begin position="36"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="7">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI08814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="269" mass="29034" checksum="454A555DFA9143C1" modified="2018-11-07" version="1" fragment="single">SLLPPKSRRPKRKPCLLRTRTSPPPDPGVQPSSRPSFIPLEANPQLMTTLLHRLGVSPALQMYDVFSLTDSDLLGFVPRPALALLLVFPVSAAYESHRLAEDSLVEEYGGRGGGEPVMWFRQTIRNACGLMGLLHAVTNGPAADFIEPNSTLHELRKRAEPLPPHERSALLEGSSELAKAHREAASVGDTAAPDAEDSIDLHYVCFVKGSDGGLWELDGRRRGPIRRGGLEDGEDVLCPKALALGVHGFLEREGADLRFSAVALAAASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3P4</accession>
    <name>A0A367L3P4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_5143</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI09044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3P4"/>
    <dbReference type="STRING" id="1330021.A0A367L3P4"/>
    <dbReference type="OrthoDB" id="2014058at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008699">
        <property type="entry name" value="NDUFB8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12840:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 8, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12840">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE ASHI SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05821">
        <property type="entry name" value="NDUF_B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI09044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="175" mass="19975" checksum="FF6D6C1977B7DE7C" modified="2018-11-07" version="1">MPSLLRQLSRARALRQSLAAARPLPTTQRRCFFPKQYTSDWKILEEKYPEPKVLSEAEDPDMNGGYVNPPRIKRQHRDPHGDWWDPQERRNFGEPLHEDNDTLGIFSPHEYTWTTTGPGLIMIGCFLTVAFSMSGIIYLTYPDRPSYPREFEGGLERELGGPGAGRARMSGDPDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L494</accession>
    <name>A0A367L494_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_1392</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L494"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF5">
        <property type="entry name" value="ISOFLAVONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="3"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI09231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="293" mass="32784" checksum="DEFA03F2CA25439D" modified="2018-11-07" version="1" fragment="single">ARQEFSQLDVQLHVVDYEDGNHLAFNLQGVDLVISTVSGRAQINLIHAAVRGRVRVFVPSEFEGSISHRPDHHHHDPLDRGSSQALALLRNLARHAQIRYTVFSCGLFMERFHPSGLAYLNIGRGAAIANPGDYLVDINRATAEFADRDARGRSVRVCLSSVYDVVRFLVAAIDLGAERWPVEFTMCGDRMSLNQLVDTCSRVRNGSRRLTAPSPVHFTRHTRSIAELQAYISHFNHAGDAARTAYYQRLLATANGRYDFSHANLNDAILRSNLGEVQPLTLNQWLVIMLQST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4B5</accession>
    <name>A0A367L4B5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1575</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polyketide transferase af380 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4B5"/>
    <dbReference type="STRING" id="1330021.A0A367L4B5"/>
    <dbReference type="ESTHER" id="9hypo-a0a367l4b5">
        <property type="family name" value="Thiohydrolase"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2498029at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010520">
        <property type="entry name" value="FrsA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051411">
        <property type="entry name" value="Polyketide_trans_af380"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47751:SF2">
        <property type="entry name" value="DLTD N-TERMINAL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G00380)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47751">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06500">
        <property type="entry name" value="FrsA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="315" mass="34844" checksum="704A72AA256FF9E0" modified="2018-11-07" version="1">MQYISAQGTSSMEKREAEFKTLDGLTLRGDLYPAQSSVARGPAVVITPGINCVKEMFVPEIAQYFQKADITALVYDPRSIGISDGLPRNEIDPARQASDFSDAVTYVRDLPNVDPSQVGIWSMSFSACIAISAAALDPRVRFCINVCPTPITDYDPSKFPKVLVKLQQERESQLAGNPPLYVPLVDVRGGNIVGFGDGVDKEEGIQYLINAKMRGAPSHNINSTFLSYYRMMMWHPEGIMSYLKQTPVMTIVPEFDLVSPPERQIKMHESFPEPKLLHIARGKGHLNVLSGDDFPALAEMQVKFIKDSLSGWAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4D9</accession>
    <name>A0A367L4D9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4D9"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="352" mass="39687" checksum="6B63E984F91E7C16" modified="2018-11-07" version="1" fragment="single">MDEWQLFDEGKLRDQVPVAVRIVHGDTHAVSRKPRPTPPKRPGPSTRQRRRRSDPGLPPPVSRDTCLGSFAPHPLRPLTGREIIVVTIVIDSKKRGDLADSGGPELGKTKDAARHDRHVICRLTRLTHRARMSNEDLNSDEGLFVVNADDNALPTAVLVTRTRLASRSGRGTHYITRMYEQTSSLLFPLSPLFQVNYVKITMIEDEHSSKRMQKKKANKNQSQSGRPLLTLRHRRLGSSPPLLLLRILLIRFASPTRFQTLKKELLHKAPKSHPISSAGELGWPALTNNGREEGTREEENNKVCLHAVYNERNTADGNKRFSIYDSLSTYLKQNIAASLKDADRNGYMHNSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4I6</accession>
    <name>A0A367L4I6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">ER membrane protein complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_3693</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000015">
        <property type="protein sequence ID" value="RCI09339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4I6"/>
    <dbReference type="STRING" id="1330021.A0A367L4I6"/>
    <dbReference type="OrthoDB" id="369569at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009445">
        <property type="entry name" value="TMEM85/Emc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19315">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06417">
        <property type="entry name" value="EMC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017207">
        <property type="entry name" value="UCP017207_TM-p85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="21"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI09339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="185" mass="20465" checksum="A567EEE782C082DA" modified="2018-11-07" version="1">MDSSLLSPAAPPWIVQLDAPPAARNRVPGIPDPPGFTSSTSGSKKRDGRLQPKRPAPTQDEMETLKLKKAWEVALAPVKSLPMTAIMMYMSGNSLQIFSIMMVFMAFKNPLVGLMSTNQAFEKFRTDGNEAKLLQTKFVYVIMQLVALAVGVWKVNAMGLLPTTRSDWLMWEPQRLSVDRAVTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4T4</accession>
    <name>A0A367L4T4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-deoxy-7-phosphoheptulonate synthase</fullName>
            <ecNumber evidence="2">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_3666</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I DAHP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="2"/>
    <dbReference type="EMBL" id="LKCN02000015">
        <property type="protein sequence ID" value="RCI09434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4T4"/>
    <dbReference type="STRING" id="1330021.A0A367L4T4"/>
    <dbReference type="OrthoDB" id="659at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1580.10">
        <property type="entry name" value="paralog of FGE (formylglycine-generating enzyme)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016187">
        <property type="entry name" value="CTDL_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006219">
        <property type="entry name" value="DAHP_synth_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005532">
        <property type="entry name" value="SUMF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042095">
        <property type="entry name" value="SUMF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00034">
        <property type="entry name" value="aroFGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009395">
        <property type="entry name" value="PRK12755.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE DAHP SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225:SF18">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE, PHENYLALANINE-INHIBITED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03781">
        <property type="entry name" value="FGE-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56436">
        <property type="entry name" value="C-type lectin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP synthetase I/KDSA" evidence="8">
        <location>
            <begin position="56"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase-modifying factor enzyme-like" evidence="9">
        <location>
            <begin position="476"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="446"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI09434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="756" mass="83565" checksum="7C4A68C3715971B5" modified="2018-11-07" version="1">MHFYTEKMRIVNKLDSEGQRICGYKTLTAPDALQVEINQTPASKRTVMESRNEVAAVMQGTDERHRLLVVVGPCSIHDAEAAMDYCDLLLSLREKLQNELLIVLRSYLEKPRTTVGWKGLINDPDLNGSFKINKGLRIARQLFVNLTAKGMPIASEMLDVISPQYLADLISVGFVGARTTESQLHRELASGLSFPVGFKNGTDGGLGVAVDAVGAVKHPHHFLSVTKPGGVAIVSTTGNDDCFIVLRGGTSGTNYDGESIGKAKSLLAKKGFRNQRLMIDCSHGNSRKDHRNQPKVAADVAPKRTSIIIIIMLMLSQIVLASSFAAAAAGITAQLVEDKLAELSGSLRWFGTTHATYSAVEPAARAAHSALVSLQTTDAKAVPRADEFIETLARLVTESHHLADLSRPKTYKPGFLDSAVFLTGSVNEWHHTIKVMRKNLLRPSTYRAPQPRSKQANDKINKATKPGTEFRDWDEGPTMVVIPTGTYTAGSSDAELDDWKVPVDRRAYEQPQRQVHISKRLAFSRTEVELSQFEAFVRETNYQVRGGARWWNPADRSVMVFNPRLNFRDPGFPQTAKSPVVAITRQDARAYAGWLSVVTGHTYRLPSEEEWEWAARGGTNTTFFWGDDPHVQQANLYANTYDQTSDRANHFQWPAANVTDGFAYTAPVASFRPNGFGLYDMTANAREFMDDSWVPFLGGGVAANDGSVHLGPAPFPVLRGAAWCYTPRNLRINYRNAYFSSEVATNMFGIRLVREL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4Z5</accession>
    <name>A0A367L4Z5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_3862</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4Z5"/>
    <dbReference type="OrthoDB" id="4918056at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI09500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="835" mass="92179" checksum="207DDBCE891904BF" modified="2018-11-07" version="1">MKAVGPAYSFNINSTHLAAQMNGRVSQTSTTAIQAVDHVNGDLLKYEVRTDDCGNSLAKCKYGNRACAVKLSMSWHKSLRARWGSNHLEPIPSISRCTCEAGHCDDLNCAMRRVCAKAGIAVGKHARQAESVLARAIAAALTHLSHTSLNWLLADAVLPPEFLTAAIGNVWPLAERMASLYALLRRSLIRIDGIRAGLDNDIMVALLTHDSTLMMVLSNLVSLYLFDQYKVMSFGEQMSPELKLAVEAARAGYDGPVQLKRGNEHICMRAAAPGFAVPRHLQWLLSSISSGGTVAATVLWPCEGSDTIEAGGDDISFYLETRLTAWPAVKMTAKDVQEVVGRIGDNGAERGLGALMALDYTILHHAQEVHQSFLDPLQGSINIGRYRRVEDLPFSAARVLFFELAEHGLYQYMVDDLRASDTKIPYDGVLMSDLLHRVQDWGIEVGSGESLQTMLGLLRASYDAVAGLCICGHVERVWVLVVTWVDHVLATQPLARTTGVAVMSALWIYTTGRHPAFVWERLGREHKCCARLRCLISRRLPNSGGVMADMRDLARIYGQWDEAKMTTPLMARIGDEPEGPVGCDECRLPDRLAAWLRVPGMVAEEGATAMQTLTATYIVHLATCQATARRKRRALLVRMFCKYMCSPGMFYVSLGRMSERGIYESARLDGDFFLGDYFQLQLSVLFLSFTDVYLLVLEDVREEFASKAKQQSALPPPLSFFLTFDRHGGTHQGFQDEAAGIENHTSLAAFRQAAMGPRGPEPGGSNAKRARCRLADGTKPLNSWLRIPGWNNKTGVAFQRRHLQQITPSDDKQRPTAIIITIRPADNTKSDTRIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L513</accession>
    <name>A0A367L513_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_1439</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L513"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI09312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="303" mass="34053" checksum="359DB1AD3CFCDB61" modified="2018-11-07" version="1">MDLVRLPMTFVFPCKFPCKENMLSDSYSTQGYYSLLPSIAKVEIGSKAFTSLLPAPTPVSLDLEFSAKRETIGNFYRVSLPLPCLLLTETNSLCSQFLWAFSPYRCMLESRARMVPPKATDLEGFLLQGPVIEDTRLSRSYHYLVGDGNFPLNTCRMENIVPGHTISSTLLHWDESIHPQCQGQNHGLRQLHKKTPRTCCSMSSRSNAVEFSIKPFFYFTMKLTDSKQMPPFVNTRLFPTEGKPTGLPPFGLTIQLGHGAVPRGNKNRKELEGWFGSWASFQPTSADDDEFYTPALLLSTVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L518</accession>
    <name>A0A367L518_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">PLD phosphodiesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L249_4087</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the tyrosyl-DNA phosphodiesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L518"/>
    <dbReference type="STRING" id="1330021.A0A367L518"/>
    <dbReference type="OrthoDB" id="2126698at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017005">
        <property type="term" value="F:3'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13132">
        <property type="entry name" value="MATE_eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09123">
        <property type="entry name" value="PLDc_Tdp1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045069">
        <property type="entry name" value="MATE_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002528">
        <property type="entry name" value="MATE_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010347">
        <property type="entry name" value="Tdp1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00797">
        <property type="entry name" value="matE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415:SF0">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01554">
        <property type="entry name" value="MatE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06087">
        <property type="entry name" value="Tyr-DNA_phospho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="655"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="693"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="737"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="774"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="803"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="828"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="972"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1012"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1044"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1069"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="402"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="419"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="304"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="12">
        <location>
            <position position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCI09507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1133" mass="123484" checksum="9A0AB8840C77D28C" modified="2018-11-07" version="1">MNAFDPDIRHAIDVHIVHGFWKSDDANRLALAQEAAQFPNVRLHVAPMPEMFGTHHSKMMVLFRRDDTAQVVIHTANMIAKDWTNMTNAVWRSPSLPKLQYASAPPSGFKADLLAYLASYDRRGPICKPLADQLAGYDFSIVKAALVASVPGRHDTRAGTLWGWAALERRLKSVPCRAGDSEVVVQISSMATLGPRDDWLQKTLFDSLAHCRAPCHGQARSRFKVVFPTADEIRLSLDGYASGGSIHTKTQSRQQTSQLEYLRPILYHWANDSRHGRGRVPHGARSLPAGSAELNSGRSRAAPHVKTYIRFNADKSIDWALLTSANLSKQAWGEARKPTGEMRIASWEMGVLVWPELYGEDSSMVGAFGSDKPDVDAIAAAGAKNGAVVGVRIPYSVPLQRYATPSPTAGAESGGESPDTGRARRDSTYIQRGDRGGRGPSDDPRWEPLAPAPCFAALTLMERGRPIPSPRFASPGRPLPGSLRMLSGSPVADDIAACSESEEDDDFIDDSLALHGHGMYRRPSGVAYGTSRPVFNQQIMEEPFLTPIERKQSRNAERSLLRDNRVLPPKHPAQAKSQNLFARIYRRLFSTRVPPAEDDVDQRIAPLPPPTERTSLLHNGADDGLADGDELEQQWEEAVASGRLRTTWQRETKTVVAYSAPLVVTFFLQYSISVTSVFAVGRIGKLELGAVSLATMTMSVTCLAPFMGLATSLDTLCSQAYGSGHKHLVGLQCQRMVAFLSTLTAPIAVLWLFSDRILVHIVPDPDSARLAGQYLKIMILAIPSIILFEVGKRFLQAQGLFRATTLVLVAAAPLNILINWLLVWKAGLGFIGAPIAVVITENLLPVLLILYVIFIDGSQCWGGFSKRALTNWWPMIKLALPGMIMVEAEWMAFEALTLIASRFGTEYLAAQSALSTLATISYQVPFPVSIAASTRVANLIGAGMVDAARTTAKVVCSLCFSSSLSWSDARQTFAAVCVVGIVNLTIYSTLRFRLPMLFTNDETVIAIVAKTLPLVAVVQVFDGLGAGAHGLLRGIGKQSIGGPANLFAYYIISLPISLGLAFGADWKLLGMWAGLIVGLVSVSIIEYTYLLMTDWHQAAAEAAARNAAGHHRSTRTTLKLGKASIYLYHMTQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5N7</accession>
    <name>A0A367L5N7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_3925</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5N7"/>
    <dbReference type="STRING" id="1330021.A0A367L5N7"/>
    <dbReference type="OrthoDB" id="5431405at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="domain" description="CFEM" evidence="10">
        <location>
            <begin position="348"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="481"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="520"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="535"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="711"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="726"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="851"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="927"/>
            <end position="952"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI09532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="977" mass="103222" checksum="B020CC03A2C6EBD0" modified="2018-11-07" version="1">MIPLTNQLFIVFFFFFSLACFGAPSFVFIQSLPLQELPSHSLIDISTLASLVMRTSLVLLVASALAGQASASLLMKGQLLKQFVRAKYERKPANDKLNVCSPQQQQGWGDYQGLQPEQPVTEYGNVRLDGFVAKQDEDGPAAIGRRTLALHLQGDTSKLHGEAPSISSGDEGNGFSIKEVEVMCDPAGILTMTFVKPGGVTCRLPSRCADKKFTIVNDKCSDAVRVSFEWNRNYKLPSELLFGYKKSSQLANKAMDKFGVDYMKLYRITWDCEERKQQTLQPHPDQTFVLPSQEDVNGHTETTGTGAGETVVVHGEGTLQDSSEDITSPSTVSLQAGQSAGEAFFPSLLPSCINTCIAELGLNCQNNLDVSCFCPNEQFAQRLYSCVNANRGSEQDFVKAKEVYGGMCISHIPKNPGIVTDASTFLGSMAIEPTPCFAPSDYTTVVVPTTQIEGQGVVVTVTETISIPQIVLPTVVPGPGWFGGQSGGDSLEKPQSGSEESRPVLTALEQQPTSVPEGHQPQPGLGGFTFQQGLGEHKPESGDKLGLDAYKTDSGTKEHKPQPGTEEYKPQSGCKECAGIPNGPKAPEPQPATEEYKPQPATEGYKPQPASEEYKPQPATEGYKPQPASEEYKPQPATEGYKPQPASEEYKPQPATEGYKPQPASEEYKPQPATEGYKPQPATEEYKPQSGCQTCAGVPNGPKAPEPQPGSNPISPQSFNTAMDKGGPPSSPESYEPGTGPNPSSPQLSEPAVDKGESPASPESYESGTGPSSEPAADKGESPGSPESYEAGPGSRKSVIKLKGKPGKQGAACVPKPKGPTDSSPEASLPKEKSPEPDYGSPKLSNAGEAPKQEAPKKEAPSTPSAGKPYSPEPAGSRSVPSAGGPKSPVGPGYGDDKESAVGSPKTGKKVTQQPGPKDKPSKSSPNFNGTATKSTFGSIAVQTGGYSTPKYGNSTVNGASRAGLGLFAVVAAIAAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L628</accession>
    <name>A0A367L628_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_3851</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L628"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI09858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="127" mass="14472" checksum="4138AE7F679C0A9D" modified="2018-11-07" version="1" fragment="single">ASSSSVRSYCYTRLLRRLCEVWPSNGAGWVEGLMPLLEGTFRQSKVALDYLNKVQIYQYLDNLFSNVMIGGSKVTLRVRAQRDKSLHPELLFHSHATLSTKHLHYQADEELPALTHSYAETRTDLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L629</accession>
    <name>A0A367L629_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA helicase</fullName>
            <ecNumber evidence="4">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_3877</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="4"/>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L629"/>
    <dbReference type="STRING" id="1330021.A0A367L629"/>
    <dbReference type="OrthoDB" id="6692397at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045025">
        <property type="term" value="C:mitochondrial degradosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000965">
        <property type="term" value="P:mitochondrial RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17913">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18805">
        <property type="entry name" value="SF2_C_suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000269">
        <property type="entry name" value="ATP-dependent RNA helicase SUPV3L1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000957">
        <property type="entry name" value="ATP-dependent RNA helicase SUV3L, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055206">
        <property type="entry name" value="DEXQc_SUV3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022192">
        <property type="entry name" value="SUV3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041082">
        <property type="entry name" value="Suv3_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044774">
        <property type="entry name" value="Suv3_DEXQc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22527">
        <property type="entry name" value="DEXQc_Suv3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12513">
        <property type="entry name" value="SUV3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18147">
        <property type="entry name" value="Suv3_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="283"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="640"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="849"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="642"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="859"/>
            <end position="868"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI09880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="923" mass="103027" checksum="0CB9DDAB53E23D6E" modified="2018-11-07" version="1">MDESRVSARFLDDSSPQSQVDFPQITPPLPEATVVAAQLEDDVTSAYTRIFLDLKMSPVVSHEFRRREFDIRMHRVNAAIEDCFLLVKNRLVLRQYNPLYHRLSQARNANMLDNELRHIMTASLFKDRITPDMEITMKRLTDFTTPYDWFPATRTMQRTFHIHVGPTNSGKTYHALQALEKSKSGIYAGPLRLLAVEVYDRMRAKGHACALITGEEVRLPEDTDCYLISATVEMVPLNRRFDVAVIDEVQMVSNVERGSGWTAAILGVQAKDIHVCGEERSVDLIKKLCATTGDSCIVHRYKRLNTLHTAEVALGKRLTQLQKGDAIIAFSRKKLLQLRTSIEKATGRRCAIVYGALPPEVRKQQAELFNQPGNEYDFVVASDAIGMGINLGIRRVIFVSKSKFDGGELRELYPYEVKQIAGRAGRYRTAANPTSGEAEESGGWVTTMLPEDLPFIKEALNAEMPPITQAAVDAPVGVVERFATFYPPGTQLAFILMQIKAMATMSPLYHLNVGKSVLTIANVLHDIPLSISDKMTFCYMPAALQVHGALDVMRALAKIVASGQVVDLLDMPEMPLQYLNDDAVDYYGTDEYLRRLESLSVALNQYIWLSYRYTSLFQSQKTALHVRDLLAQKLIDTLTEPSSDKKENERKLEEKRRSGEMERRIASVQYYTRRKRFFNDGEDEELGMPKTPAEAEAQLEKQIEVTEDTVATAADPAGGVSVEQWVTLLTQAEIEAEVNSEDVERHLEAIADEAEDDTEEDVSVEQWVDVFRSGAKKKPRIAPRLSEVMEAAAANTWTKEATRGGANEKQWFSPVQLDEEKEKKNKWFSVRPEEEVMAGRAFAGMLAASKGSGEGGKSRGVSGKSGDGVMDTRGFEAALRGGKGSKDVVVENDDFKAALRDAKGFKHTGGFKGVGKGKPVKAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L634</accession>
    <name>A0A367L634_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_3868</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L634"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI09682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="93" mass="10774" checksum="327A62E9719565FE" modified="2018-11-07" version="1" fragment="single">STITWLYVTPFCSTTIEVGRYNRYWYSASIAVTITRADRCNDRCNESIGRYDRYSPTVTQGVVAGLRPNWYNLFQVALQAYFLSVQDEKICII</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L644</accession>
    <name>A0A367L644_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dicer-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="25" type="ORF">L249_3857</name>
    </gene>
    <organism evidence="25 26">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="25 26" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25 26">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="16 17">Belongs to the helicase family. Dicer subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="25">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367L644"/>
    <dbReference type="OrthoDB" id="416741at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051607">
        <property type="term" value="P:defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050688">
        <property type="term" value="P:regulation of defense response to virus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18034">
        <property type="entry name" value="DEXHc_dicer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000015">
        <property type="entry name" value="Dicer-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.380">
        <property type="entry name" value="Dicer dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038248">
        <property type="entry name" value="Dicer_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005034">
        <property type="entry name" value="Dicer_dimerisation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056755">
        <property type="entry name" value="DSRM_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950:SF62">
        <property type="entry name" value="DICER-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14950">
        <property type="entry name" value="DICER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03368">
        <property type="entry name" value="Dicer_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24995">
        <property type="entry name" value="DSRM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00636">
        <property type="entry name" value="Ribonuclease_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51327">
        <property type="entry name" value="DICER_DSRBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50137">
        <property type="entry name" value="DS_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00517">
        <property type="entry name" value="RNASE_3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50142">
        <property type="entry name" value="RNASE_3_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0051">Antiviral defense</keyword>
    <keyword evidence="4" id="KW-0930">Antiviral protein</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="26" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="13 17" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="22">
        <location>
            <begin position="140"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="23">
        <location>
            <begin position="462"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="domain" description="Dicer dsRNA-binding fold" evidence="24">
        <location>
            <begin position="649"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="domain" description="PAZ" evidence="21">
        <location>
            <begin position="877"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="20">
        <location>
            <begin position="1106"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="domain" description="RNase III" evidence="20">
        <location>
            <begin position="1299"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="19">
        <location>
            <begin position="1486"/>
            <end position="1563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="926"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="989"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="31"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="926"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="989"/>
            <end position="1014"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00035116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS51327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="EMBL" id="RCI09692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1578" mass="178313" checksum="63DA48BAC9B8D7B8" modified="2018-11-07" version="1">MSPSDTKMPPMLASSEASPQLQQTSPPPAPDEAEEQEEEETTKSPSPLEPDASDSIPSDSDDDNAIDRYRHLPQGGIVDRRAPSARRRRGDAAFQQWIIESQKTPADQVRSVDRFTTANLIKHNEEKRIITSPREYQTELFERAKDRNLIIVLDTGSGKTLIAALLLRHTLDHELERRALGEPPRVALFVVDKVALCVQQYSVLRANLEHPIAKFHGELSGVLRTKDYWAQQLVDNMAFVCTAQVLLDCFNNGFLQMGQVNLLIIDEAHHTKKNHPFARIIKDHYRRQPQASRPRILGMTASPVDTQTRDLRAAASELETMLCSEIATVSDEILMQSQAQRQQLETKESYSKLVPPEEARTPLWNKIATLMQDDYAYRIHLDSTLEAASTLGPRCADRYWELLVTDAEVVKRTGQAHAAGAGEADKVQENMRNLQLVIRENALDTVTRTDAYSSKFTTLRDCLEDAFTRQDTRRCIVFVQKRYTALLLADALQRTEKRITGLKPSYLVGTQTASGLVTMTFRDQVLAIQRFRRGETNCLFSTQVAEEGIDIPECDLIIRFDLYDSAIQYIQSKGRARKAQSTYVSLVEAGNRQHLRRLKQATKDANALRRFCSALPADRKLQTYVDDLDQRLENESIMQKSYEIKETGARLTYSSSLEVLAKFVASLETSALPEYVVTLLPTKKFVATVILPESSPISSQEGSPQRNKQTARCSAAFQVCVKLIQRKLIDGHLQPTLKKQLPRWRNARLALSANKREQYTMRVKPDVWTQLGPFTDAFATVLSLEEPSAPGRPTSPLMIISRFPLPRPEPTMLYFDQGRTTTARLGSPSPIGLSPEEAEALTRFTLAVFRDVFSKEYSATAEDMPYLFAPVADGPRVDWEAAAQAGAEAPNWRGQPDDFFEHKLVMDPWDGSRKFILCGVDKSLKPSDRVPDGVPEPKSRSYRDTDKSIKEYSNSLARGSRGRQNWREDQPVVKAELLSIRRNFLVESEEEEKEKEEEEEEEEEEEEEKEEKEEEEKKKKRKKKKKKKKDMHCWIILEPLCLKKKKKKKKDMHCWIILEPLCLSALPIGIVSMALLVPVMMFRIDSALIAHEACGILDLQSIRPSLALEAFTKDSCNTEEHGQEQVDFQVGMGPNYERLEFLGDSFLKMATTISLFTLLPWCDEFQYHVERMLLVCNLNLFNHAVDRKLQEYVRSKAFDRRSWYPNLPLKKGKLPKTQFWHCLSDKSIADVCEALIGAAYLTGRDDDDDKMSLDLAVKAVTKMVRSKRHKMVEFGDYYEAFAIPAWQTAPATAAQRAAIEPIHQATGYRFRRPALLRSAFKHPSYPYEDTIPNYQRLEFLGDALLDMVVVDHLFHRFPDADPQSLTEHKMVMVSNHFFGYLTVKLGLQRHLLMTTSRLMSQVTGYVAEMEMVAAAAAAAGDETESREVWLKASAPPKALSDMLEALVGAMFVDSGYDMDVVRAFFDRIVRPNFQHMTPFETYVADHPVTALTHLLQNTLGCQDWRLCVSAVPCSVERGAAVMTDDDVVCALMVHGRALTSASARAGREAKAAAAEKALAMLRGLRGGVFGERTGCDCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L678</accession>
    <name>A0A367L678_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">3-ketoacyl-CoA thiolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L249_8482</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI09908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367L678"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF8">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="13">
        <location>
            <begin position="34"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase N-terminal" evidence="13">
        <location>
            <begin position="173"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="14">
        <location>
            <begin position="390"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCI09908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="510" mass="53474" checksum="3BE5DD39E6745CBD" modified="2018-11-07" version="1">MGALERLSQIGGQLSANMSGGGRQRLLEKRPDDVVVTACCRSALTKGGKGGFKDTQAADLMAGVLRAVADRSQIDKALVEDICVGTVLAPGGGATEMRAASLVAGYPEXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXICVGTVLAPGGGATEMRAASLVAGYPETTAVRTLNRQCSSGLQACVDVANQIKAGMIDVGIGAGVESMSLQYGPSAVTEFSEQLEGHTESANCKVPMGVLSEDMAKDLNITRAAQDAFAASSYQKAVRAQAQGLFDQEIVPLTVRYEDPKSGEAKEITVSKDDGIRDGITTESLGKIRPAFASDGSIHAGNASQISDGAAAVLMMRRSTAERLGQPIIGKFVCAAIVGVKPLLMGQGPWKAIPRALDLAGITKDDVDIFEINEAFASQCLWCANQLGIPHDKINPKGGAIAFGHPLGCTGARQVSTLLYELRRTGKKIGNTSMCVGTGMGMSAVWVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6C1</accession>
    <name>A0A367L6C1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8587</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI09959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6C1"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="130" mass="14195" checksum="B16A7C33FD1DB2FF" modified="2018-11-07" version="1">MTPGSGDGSSPCEAEEENPADPGLPFYLTYLPTYLAERGVKGSVPPPNDTQAVDQGLIPYGWAFVSTMVNDEQPLPTFCFPPSMPEKKMVNAWQVDGRTGPTEGWWKMGWKEMGDRDSPGLPSLTADQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6F6</accession>
    <name>A0A367L6F6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DlpA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_8498</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI09988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6F6"/>
    <dbReference type="STRING" id="1330021.A0A367L6F6"/>
    <dbReference type="OrthoDB" id="1476984at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047443">
        <property type="term" value="F:4-hydroxy-4-methyl-2-oxoglutarate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008948">
        <property type="term" value="F:oxaloacetate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16841">
        <property type="entry name" value="RraA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.40">
        <property type="entry name" value="Ribonuclease E inhibitor RraA/RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005493">
        <property type="entry name" value="RraA/RraA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036704">
        <property type="entry name" value="RraA/RraA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33254">
        <property type="entry name" value="4-HYDROXY-4-METHYL-2-OXOGLUTARATE ALDOLASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33254:SF4">
        <property type="entry name" value="4-HYDROXY-4-METHYL-2-OXOGLUTARATE ALDOLASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03737">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89562">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="157"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605493-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI09988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="29779" checksum="6A542F40E0821B8E" modified="2018-11-07" version="1">MLAAIVASAARQPRLQPLLTSQRRHLMASLSPSPSASPSHPFSSSSSSSSPIAAESIARLRQHTACDVSDALLKLKSPAAGFIADLNVYGKPCKTTTIAPVSTVLFAAKGQTPTSQDDDHPLPPSNLPANLHWTDVVEPDSFVVIKQPPGQINAVCGGIMALRIKIRGAKGIAVAGRVRDVAELTSTELPVMYAKILAYGTSTVGAGAGSVAWALQVPIDINGVTVKPGDVAFHDPDNGFVVIPRDKLPQVLNLMPKLVAADDKVKEDVGRGSSVHDAFALHRGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6Q5</accession>
    <name>A0A367L6Q5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L249_8492</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6Q5"/>
    <dbReference type="STRING" id="1330021.A0A367L6Q5"/>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="17"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="BCS1 N-terminal" evidence="16">
        <location>
            <begin position="48"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="15">
        <location>
            <begin position="268"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="445"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="528"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="564"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="597"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCI10089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="607" mass="67489" checksum="8A57B3D65C62E757" modified="2018-11-07" version="1">MDPEAVIPGAPSPQFAIINYLLPGFSVFSAAANTYLGADVGRYLPVIVVVLAVVVAWGHVRDSLWALIDDFFMSSVRIRTDDEIYNYVMLWLSKQKFAKASRHILANTNISSRNSYMYRYADSEDEDEEEDDGGGKALRYTPAFGSHWFWYHGQPLVFERHQNREHMSFETASEREELSLSCFGRNPRVLKELLLEARAMHVRRDKRKTLIYRGNLASTCWQRCMARLNRPMETVILNERVKQQLIDDAADYLDPVTRRWYTNRGIPYRRGYLLHGPPGTGKSSLSLALAGYFGIKIYMVSLSSASATEENVTTLFNDLPTRCIVLLEDIDSAGLAHTRDDAVSSLSSSVPSPVSPVPTPTGVRAPQPAPAMGGRLSLSGLLNILDGVASQEGRILIMTTNHVDKLDKALIRPGRVDMTIPFGLADKDMISSIFSAIHTPYDDEAAASRRRHGANDDVAGTKSSGERTKPELERIRLLAERFASRMPEMEFSPAEIQGLLLRHKYSPEAAIAATEDWVARMRKDKREHAEREAVKQQEMAQAEAEKPCSDCPDSASRATNGEEESVRDVSRSRDDAVVAVDAPQTDVKASAEKAKAKNASDSGYDTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6X3</accession>
    <name>A0A367L6X3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6X3"/>
    <dbReference type="STRING" id="1330021.A0A367L6X3"/>
    <dbReference type="OrthoDB" id="5346713at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902412">
        <property type="term" value="P:regulation of mitotic cytokinesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045342">
        <property type="entry name" value="Etd1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20162">
        <property type="entry name" value="Etd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="606"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="719"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="857"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="957"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1038"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="305"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="349"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="432"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="473"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="618"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="875"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="885"/>
            <end position="899"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1146" mass="123933" checksum="33F2324888897DE3" modified="2018-11-07" version="1">MQTVPSLVGSGTAIAAAASGLPNLALTVSAGHPTDNFVSPRPAATSTNPEPSHHHRTTSHPSPPSRPPLSRYQRPKSSQFSNTLPLVKPAEPSSSIGRRDSASSNGTWIRRLSIRPLSQHGSVRSSILTESPSVTFSNPWSTAHLSDTTSLSSSSRPNKLVKRPSTARNSLGLGDISPRQWPKSHLSSLRRPTTSHQRPGTSQLFRPDSHVPGTPPSSKHSFDRPIRPEELLGVSPFGVPVNPGLASGSEWTSFFHSRASKPAASLGPQDYPGDASLPLRGLSLKRICPEGARRQSTPHLIKPRMLSSSMGSTLSPSSPTNASSDRPPKPPIDVPASSEAIPPTRTIRSLSASFSSASSWVTKRSGSLRRSKRGSDRRSSKSQRHMSDPPESTSPPYQRDIRPPSESPDSSLVVPKMPLPVDQEVHQRLPLPLTLSPTSPSPSIVARSGGDLSRSAGRSRGTMARQNRPNHPSGSSTSSTVISQFARVSLHERSPVTEGFDGDARGFTSGDDDDTDLKSDTLFDSLRTLASSRARVIDTPLESVYDESPPSTAGNGKTMRLSVQDVLGRSWDEEDRIMEEEDEHRLTSAHGFSTHDRAKFMAVPRPAGIAPGQSTLDDALDDDDEDWTKDDDVTFSKSPSAPPKGTSARPRGINPNVQMALPSVERGIRSLTSTPTGRPDRPLSNLFDWSETSAHGKHEGGENCLRPKTAYAIPLADSRGGRAAVRKGPTPTHVRSQSVPVVHDSPEESKPAGPKYGTWGLSTKTVSEDWDEDFEFGAGAGDGKDGPAGRDREDVFAVPESIRATQPSVRAHSGQIRELSLLVNDLKRLFRHGRELNMLNGEQTGLWREAEGIITLASPDEDDANEGPRTESDSDQWGASVDSSEASKWRTTVVRERQSPRRRSVLSPEEDVFGASWPTAEDCGGQQDRTGTPRTLDGKTSDVSGVVRCVMESLRKPARPAEAARPSRSNDGCHGRVQFDTNNLKELVKRAGELRDVLSDMIRKADWMTQSPTTTTTTTTTTPRHECRLDSSPAFTRMFDDPCSTPPRRVPRSRGSNLLMEGTPSPEKSSSSPMGPKAMTFMHSDGPQPRVISRKKKAEASNQQHLGRGSIDGSSALGERIDRLAASCYASPLDVCRSIIRSRLGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7C1</accession>
    <name>A0A367L7C1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7C1"/>
    <dbReference type="OrthoDB" id="4825861at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="154" mass="16931" checksum="5F4CE631FEC4760F" modified="2018-11-07" version="1">MAIRDRIRRVLHKTNSSSGSDSSSRSVVPDGTTTSDMTTIVKTTSPPSTFARVFNNLGARSDRGGDDGRRREPRMPRTRRRGRKIHPSLRPLTAQNLQHQEMLSHFTMTFGATDPDQIESLSFCGISPCCTRTPSVQGDLAALQSTDTEPGLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7X0</accession>
    <name>A0A367L7X0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4366</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7X0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016620746" evidence="1">
        <location>
            <begin position="37"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="79" mass="8854" checksum="09FE99214522B5F2" modified="2018-11-07" version="1" fragment="single">MGVDDWCWRAASRAPKEKFCCLMLPLLSFLVHLCLPHVKNPFVWLDVVAELTSVCHSLAPDKRLHSTSRHMLEAQGGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L894</accession>
    <name>A0A367L894_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_4324</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L894"/>
    <dbReference type="STRING" id="1330021.A0A367L894"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000127">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051834">
        <property type="entry name" value="RING_finger_E3_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931:SF16">
        <property type="entry name" value="RING_U-BOX SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931">
        <property type="entry name" value="SI:CH211-59O9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="492"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="244"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="543"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="253"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="546"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="593"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="630"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="660"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="689"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI10452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="708" mass="76149" checksum="4F1ED39B7B825999" modified="2018-11-07" version="1">MTNISTYPAQLARWATSWYFESKLSIRGNATTAKSYAEVPMFGRTSASGLNLVFAALLPSALLAHAIDFGIVISILPLSRRSSASSSSCLPLLSPAPTAPTSAWLVSYVLQATLSASEQHASGVYSTPTSHRIGVSQARRCGCLIAFLFFSRFFLRHARVDPALSSPTLAFRAIRAAGLAIGLGLTAFNVYQRRQEQMASVGRGRLDATSDRAVVYCHACSNEWYRDDHGLMCPSCGSDITEVVDLNSDPRPPRSPPTSYSPPMRPAHYDDDSDPDMADIEEFAGPHGFIHRRSVRPGRDDTEHHDPGVEPVIHRFYEMLQTFSTARTAPGRGDPDRGEEGPHVWPRIQRTTFTSGPFGGGTASVTIFSGPPPSRQPPMADAQDVFPPDPFQAVLSHVLRDLSVPPQGDQQGEHPPQFARGLQEILSLFNPANAMAGDAVYSQEALDRIITQLMEANPQSNAAPPASEEALRNLERKPVDQEMLKGESKTECTICIEDMTTGDRAVVLPCKHWFHEECVVLWLKEHNTCPICRTAIETAGANNGSGHDGGGGGGGSHVTMRTMPRTRSGGQQGPGPSRGLRSFRGSMGSYRPVRFERAGSHLMSDRSERERGRETPSQRVYHLAAAWPRPTSTSHEGVDVGTSSAGDVLLQRSPSEGSRRGQGGGGGGGGGGGGGRLVGPINWLRERFAGGGSGGGSANGATRDERRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8I5</accession>
    <name>A0A367L8I5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_5308</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8I5"/>
    <dbReference type="STRING" id="1330021.A0A367L8I5"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019185">
        <property type="term" value="C:snRNA-activating protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051575">
        <property type="entry name" value="Myb-like_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621:SF1">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="359"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="408"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="76"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="316"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="454"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI10724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="496" mass="54398" checksum="7EB339FE0B199875" modified="2018-11-07" version="1">MTYSKEAELAGRPGLETDGKRTTLSAHSVETVQSRGLWRNPWAGVTLADNYRVGGYNVDYSGQGSHTSGLTQQLQYNSSSSVHNHHHHQHHPQPAYPSGPTQPPPHLPPPPPPSLAHHHNHQPQHPFQPAQQQQQQQQQQQQHTHHHRLHHQSSPAQQPSRPQSQQQQPKRQSSLAPSSQHLSPVNLPGVCSTVATNKAAAESSPHGHLPSLSIGAMGQKQSDTAPGQQQAQQQQQQSPQVSMDALQGHRLGHVPFGAASNVSTPLYGAVSSPNQSPYASYSAPLGKRTRPEDFDLSMAVVDTSGLEGYGSAPAQAQQMHHHHHLPDLGPPSKSMRREEGGGAAPSMVGQVGMPAPAPRPRGPKLKFTAEDDQLLIELKEQKNLTWKQIADFFPGRSSGTLQVRYCTKLKAKTTLWTDEMDQKLRKSLQDYENEKWRIVAHKVGSGFTPAACRERAGQLAGEEGEEEPTEQLWQSLSPKAASLPESMEMSHSQRPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8L9</accession>
    <name>A0A367L8L9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5347</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8L9"/>
    <dbReference type="STRING" id="1330021.A0A367L8L9"/>
    <dbReference type="OrthoDB" id="4509994at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI10773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="97" mass="11079" checksum="21D77DC7111AF7E9" modified="2018-11-07" version="1" fragment="single">KIRTNKATFRDEEDRIGFLFRSLEGKACKTLETRLLTKTKDNSLSYKDFCGYIKDLAIKRLDAKLVLPNNLPALAKYSLLILLPKTPLLNRQIDPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8Q3</accession>
    <name>A0A367L8Q3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5408</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8Q3"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="72" mass="8325" checksum="A9E477B483A4BA0F" modified="2018-11-07" version="1" fragment="single">RLQRGRVRTYRGHSGRVIAVIAGVIGSDRSDRSDRYLSDSGYLYTFNLFFTAFLFTFCPTNYLIRTLFSNAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9J4</accession>
    <name>A0A367L9J4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Nitrogen permease regulator 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 5">Required for meiotic nuclear division protein 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_7322</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 5">Mediates inactivation of the TORC1 complex in response to amino acid starvation. Required for meiotic nuclear division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Vacuole membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the NPR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9J4"/>
    <dbReference type="STRING" id="1330021.A0A367L9J4"/>
    <dbReference type="OrthoDB" id="18648at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056603">
        <property type="entry name" value="HTH_NPRL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005365">
        <property type="entry name" value="Npr3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13153">
        <property type="entry name" value="CGTHBA PROTEIN -14 GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13153:SF5">
        <property type="entry name" value="GATOR COMPLEX PROTEIN NPRL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24064">
        <property type="entry name" value="HTH_NPRL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03666">
        <property type="entry name" value="NPR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="GATOR1 complex protein NPRL3 C-terminal HTH" evidence="7">
        <location>
            <begin position="665"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="149"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="545"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="545"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="558"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI11084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="731" mass="81508" checksum="17771AE3FD864B39" modified="2018-11-07" version="1">MHAAGLRPSSGITVMAMPGVNKQNLLAVALVINRSRDGPAFVFHYPPNVQPVNSISPTPAEAAEAADDASLHASRNLSSDVLRHHDDDLMAESGASTVLWERLAGFPTRDLAGILTPARSYHKKLFQLSLDPLVCISYPVHVPENGRWKRARKLDKSRAPSASKPPDEAAETEQQPEVVKDSTKDDADDEKRSSMTMFNLVFILLPKKNELKELVDALYGNVVKKINKAYRYSQQHSDFVWKESKRILAAKDKAREDGVTNVGALWKEILHMSSLAASLHDMYEAVSQNKMATLHLDTAAGVLSPSVQIPAPCYVSDIPADHDRGRRGLWLTTANAFLSQDALDEPGFLDRNFALLLMEDEKKIIAELQADRDPTTLSMVEFVRLAKPTMSFYQVGQSDVLTLGQVRKYAQHFIFWRRAIAIPPLHARDTYMVSPNCHLGRLPQASHEWQRAFPVAPPLPNFLAELSMCPRAFKTFCPTKAHRPLYLRMLAWLMRGGWVTQLCTFAYVVVWPEIIYEVDYEMEAEELAAAAEEARAQQEAVAEAAATVAAAEAAAESRDDDDDDDDDDNNDDDDNDVIVVLNDNKDYDDDPPSAHPHQDSASAAAAEKARLERMSARAHRAAADKATTHTRKTVPVATAHPSTNEGPHLTGLTPHLILDAKKATGKESRYLSAIAHRFRDDKLRSAWPLMCKYFDGRCALERIALQVDMRRNEAWALLTAMNEYLLCTRHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9K8</accession>
    <name>A0A367L9K8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">60S ribosomal protein L33-A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_7301</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9K8"/>
    <dbReference type="STRING" id="1330021.A0A367L9K8"/>
    <dbReference type="OrthoDB" id="1166329at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.190:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.190">
        <property type="entry name" value="translation elongation factor selb, chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00573">
        <property type="entry name" value="Ribosomal_eL33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001780">
        <property type="entry name" value="Ribosomal_eL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018266">
        <property type="entry name" value="Ribosomal_eL33_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038661">
        <property type="entry name" value="Ribosomal_eL33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10902">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01247">
        <property type="entry name" value="Ribosomal_L35Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01105">
        <property type="entry name" value="RIBOSOMAL_L35AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI11107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="129" mass="14446" checksum="66ADE932BF0EE6D5" modified="2018-11-07" version="1">MPSESGHRCFACSPFQHKALFRPDYCAALCFLTRMLSLDRSRHVTNPGTSLIKIEGVDDTNAANFYLGKRVAYVYRGHREIRGSKIRVIWGKVTRPHGNSGVVRARFTSPLPTKSFGASVRVMLYPSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9P8</accession>
    <name>A0A367L9P8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Retrotransposon Copia-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7491</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9P8"/>
    <dbReference type="OrthoDB" id="3599317at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI11147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="19703" checksum="C30AE2A7E95094BD" modified="2018-11-07" version="1">MGIISISFSHLLNTNTSPASNSSSIASFRLSPRVQLSDSGYLYTFNLFFTSFLFTFRPTNYLIRTLFSDAFQQSDPLFLKKFPLSATMGNDQKYSFAKLSGSGNYTHWALRMDSLLIREKLQGALGSIAHNKSEDALALIRLQLEDGPLTQIMHLRSAKEAWDKLKDLYNPGYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-05-03" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBB4</accession>
    <name>A0A367LBB4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7433</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBB4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI11720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="100" mass="11705" checksum="3BAFB534E4CCB2F2" modified="2018-11-07" version="1">MRKNVGKKWVFCGAVEEEEGGEKEEEEESRDGLKEAIEEELEAGEVFVLRRYFSRYFKVPTCSTLTYLYKIGDLEEDLYVPYPAVSAVLRGVWVRIRLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBC1</accession>
    <name>A0A367LBC1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7431</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBC1"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI11723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="57" mass="6823" checksum="C140376175DFAE73" modified="2018-11-07" version="1">MLIILPSRYFSRYFKVPTYSTLTYLYKIGDLEEDLYVPYPAVSAVLRGVWVRIRLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBE2</accession>
    <name>A0A367LBE2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7672</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBE2"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="75" mass="8215" checksum="B41C1647B086D7E1" modified="2018-11-07" version="1">MGDDVLYDSPHLTHCGASKQRAGQQTAVCLSSLLPNRKAPFTTITTDATHSTKPPGPAQARDPLRRQFTRRNLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBM6</accession>
    <name>A0A367LBM6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBM6"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI11833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="129" mass="14306" checksum="719AC6947045C257" modified="2018-11-07" version="1">MVPPLFTGWRLVIDQPAAPPLWSNNHQHDEFSSRIDINLQASPQTCHPSQATHSSSTPIQTCSHLKPYHFLGYLSILHNIHTPPLGPNNLASPFQLLSSLDFSALSHVRADISCLSTKTVDCNQDSVWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCS5</accession>
    <name>A0A367LCS5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Deoxyribose-phosphate aldolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_0853</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCS5"/>
    <dbReference type="STRING" id="1330021.A0A367LCS5"/>
    <dbReference type="OrthoDB" id="361029at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18086">
        <property type="entry name" value="HsC9orf114-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003750">
        <property type="entry name" value="Put_MeTrfase-C9orf114-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12150">
        <property type="entry name" value="CLASS IV SAM-BINDING METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12150:SF13">
        <property type="entry name" value="METHYLTRANSFERASE C9ORF114-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02598">
        <property type="entry name" value="Methyltrn_RNA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI12211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="37035" checksum="948666ECF0A048F9" modified="2018-11-07" version="1">MPHHEPHAKKRKTGPHESFKPSASFTPQTGGREWTISVAIPSSILTNLATADQRVAVPGRIARALAVFSVDEVVVFDDSPPSTRPPRTDTAAYTGDTDPCHFLSHIFSFLEAPPFMRKTLFPLHPNLRLTALLPSLDMPHHPNPKEWTAYREGVTVGRGTKKGSTVVEVGLDQPVEIDVDIPPKTRLTLRFPDDENSPPECIDPSAPRTEGGYFWGYAVRRCPSLSAVFTESPYEDGYDVSIGTSERGSPISDAFPASSPRPLSFKHLVVVFGGPRGLEFAAMNDEELSGRAIQGSKTKELFDYWVNVLPNQGSRTIRTEEAVFIALTALRGLWDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCT7</accession>
    <name>A0A367LCT7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cytochrome b5 heme-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_0132</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCT7"/>
    <dbReference type="STRING" id="1330021.A0A367LCT7"/>
    <dbReference type="OrthoDB" id="10254877at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF28">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="7">
        <location>
            <begin position="2"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI12042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="552" mass="61255" checksum="04F2D62DBBDC6836" modified="2018-11-07" version="1">MSKVFTSTDVASHNTPDNLYIIVDGDVYDLTKFQDDHPGGKKILQRVAGKDASKQFWKYHNEGILKKYQAGLQVGSLDTKPKPKPKARPAAPAAPKAKTTGHEAVSEALEPFGHQIPFADPAWYQNYHSPYFNESHAALRAEVREWIDSDVMPNVTEWDEAKKVPDEIYKEMGRRGYLAGLLGVKYPTKYASGGVASVPPEQWDLFHEMLVTDELSRTGSGGFVWNIIGGFGIGCPPVIKFGTEALKDRIMPGILAGDRRICLAITEPDAGSDVANLTCEARLSDDGKHFIVNGEKKWITNGIWCDYFTTAVRTGGPGMNGVSLLLIERGEGVTTRRMNCQGVWSSGTTYITFEDVKVPVENLLGKKNQGFRGTLTTTTTTTTLDTIFFIMTNFNHERMGIIIQCLRFSRCCFEESVKYANKRKTFGKKLIDHPVIRLKLAHMARQIEASYNWLENLVYQGDKMNETEAMLRLGGPIAGLKAQATVTFEFCAREASQIFGGLSYSRGGQGGVVERLYRDVRAYAIPGGSEEIMLDLSMRQSLRVAKAMGMKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2024-01-24" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCX3</accession>
    <name>A0A367LCX3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_0740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCX3"/>
    <dbReference type="STRING" id="1330021.A0A367LCX3"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI12261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="119" mass="13758" checksum="B5CE0370E9C95833" modified="2018-11-07" version="1" fragment="single">HYKDIRTFSKKKGEFSAFLTNLKDKIRTNKATFRDEEDRIGFLFRSLEGKACKTLETRLLTKTKDNSLSYEDFCGYIKDSAVKRLDAELVLPNDLPALTKYSLLILLPKTPLLNRQIDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDB1</accession>
    <name>A0A367LDB1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_0152</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDB1"/>
    <dbReference type="STRING" id="1330021.A0A367LDB1"/>
    <dbReference type="OrthoDB" id="340962at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd20524">
        <property type="entry name" value="CYCLIN_CCNH_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20525">
        <property type="entry name" value="CYCLIN_CCNH_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031658">
        <property type="entry name" value="Cyclin_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF8">
        <property type="entry name" value="BENZIL REDUCTASE ((S)-BENZOIN FORMING) IRC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16899">
        <property type="entry name" value="Cyclin_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0195">Cyclin</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="96"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="389"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI12222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="687" mass="76375" checksum="9F6F6D8F40C3ED4E" modified="2018-11-07" version="1">MRPSFLVHVLTSKPALKLLPLPPDTFLRATVRMATEDERYRQSSQFRLWSFSPARLQELRAKTNSLAKQQVAARTEATLDFLTPDEETRLVKFITVELIRAAQFCELPTEIRSTAAMFLRRFYITNSVMTYPPTELLKTCLFFGCKAEGFYIRLAKLAEKFPNTTSEQILAGEFLLCQGIRFAFDVRHPFRALEGAILELRRLRPDEEARIIKAHARAREILKFSALMTDAYFHFTPSQIMMAALLIVDPGLVDDLIPKPKAGEVSRVSADVYDKIMATIESCRVMLGEEPPERMSDYWGLMETLKSVKQLRKKLQKCRDPDRADLVALQRARREQAVAKPAKTPGTAATNDGVVFGAADRDAKRRKVGATEDPFGPSLSVVKSGTGCEETSSPTVGSSLQNQARSLPPCRSQFILQMADRKIVLITGANTGLGYQMVRALCGSDKAYEILVGGRSMEKAEKAVEEAVAEFPSSKSRVSAIQVDVESDDSIQAAFDKVKSDHGRLDGLVNNAGATFDQHIQSNDMTMRQAWNQSWNVNTTGSQVMTHVFVPLLLRSTDARLLFVTSGTSTLTGSENRELLMNKLSPKGWPKTGLVPNQMISSYRSAKAGLNMMMREWHRHLSEDGVKVWAISPGYLATGLGGSVERNRKQGAGDPVVAGEFVRDVLEGRRDRDVGMAIARDGRVQAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDT7</accession>
    <name>A0A367LDT7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDT7"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="52" mass="5811" checksum="49E761C69EA053EB" modified="2018-11-07" version="1" fragment="single">MPHGTVSTSSPFHGTMLLFPLFRFPSLLNDGASGDEVQEVAEEEEEEEEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDY5</accession>
    <name>A0A367LDY5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Aspartyl protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L249_0736</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDY5"/>
    <dbReference type="STRING" id="1330021.A0A367LDY5"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06097">
        <property type="entry name" value="Aspergillopepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000024">
        <property type="entry name" value="Endothiapepsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034163">
        <property type="entry name" value="Aspergillopepsin-like_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF23">
        <property type="entry name" value="ASPARTIC ENDOPEPTIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G15950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11 15" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016685712" evidence="13">
        <location>
            <begin position="21"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="14">
        <location>
            <begin position="210"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="152"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="112"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="226"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCI12626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="555" mass="59215" checksum="31C3DE5D62B10163" modified="2018-11-07" version="1">MHSSLYLALTLCVAALSALAAPSSKSGGLQKRSFLVKRVASPRLKPRDGVEEMAKAFNKYSIPVPRDLKNAVEKRQLKKRQLAMAAEAKGAPQRRNAMGGDQDVRLGLAAASMSQRRSLQSRQQSGGETTNQRRDTMGGDQDVRLGLAASMGQRRSLHPRQDQEPAEAEPPAEAEPPAAAETPAGDQVQAEDEKQNGSVKATPENNDAEYLAPVKIGGQEIALDFDTGSSDLWVFNTELKGQQQQAPGLQAKQKATQQEAQQGAQQGQLQKAIDSHTLYNPQKSDTFKEVPGLQFQISYGDGSGARGTVGMDIVEVGGVKTEQAVQLATSVTGSFLQDSNNNGLMGLAFSKINTVTPDKQKTFFESVMPSLQEPVFTADLRRNATGAYEFGNIDQSKFKGDMVFTPVNTTMGFWQFTSDKFAVGDGQPQQSTAGAQAIADTGTTLILADSKMVQGYYSQVEGAEMDNSVGGITIPCDAKLPDLMLAVGDNMARVGGDDMNFAPIEDGSTRCFGGMQAVPAGRMGIYGDIFFKSNFVAFKGGSGSEAPSLGFAQHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LE29</accession>
    <name>A0A367LE29_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_0870</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LE29"/>
    <dbReference type="STRING" id="1330021.A0A367LE29"/>
    <dbReference type="OrthoDB" id="194139at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016586618" description="Major facilitator superfamily (MFS) profile domain-containing protein" evidence="6">
        <location>
            <begin position="20"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="254"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="488"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="521"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="555"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI12671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="582" mass="63628" checksum="8C65FDC90DD89E16" modified="2018-11-07" version="1">MYGQKVAAVFALMALSVTALPVADASTSDEAWKFHTKDRRDMADEAWRFHSAEKRDKADEAWKFATHKDKRDTADESWKFHTTEKRDVADEAWKFSTGIVITRTALSVSHHSSPKTPMATTEQRPLLPDQTHEQALFRRRVVAMCVLFLIVVELSSSVMEPSQLQIMEDVICRRHFPLVDDGRCKDNSVQKTLAMVRSWSMSADMLIPLVVQVPFGIVADKYGRRMVLSLSFAGCVLQTWWTMLVLLFPQVFSVWAILYGSIAFAVGGGSQMGGAMIWTIVADVTPVTDRTTVFYRLHSLSLILAVVINPLAALLLSISPWIGMWLGLVTLLVGVLVIYMIPETLTLDNDDDQHVLPMPVKGSCAAFAAARKHLGHVGRFVLASRSIVALISAYGLSIPASLSIQLYILQYMTRRFGWEWSTATYVSTVSSITSVIVLLVILPSVSRMLIERCAYSTLHRDLFLSRVSSAVIVVGVSILAFAPVPWLLVSSLVISSFGAGFVVLLRALLNALVEPQAAATVNTTISVVETLFSLAGAPALGWLLSSGLEAGGPWLGLPFLVSAGCSAMAFLALSVPRLPAGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LE48</accession>
    <name>A0A367LE48_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_0662</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LovG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LE48"/>
    <dbReference type="STRING" id="1330021.A0A367LE48"/>
    <dbReference type="OrthoDB" id="2094269at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF3">
        <property type="entry name" value="ESTERASE DBAE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="3">
        <location>
            <begin position="20"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI12690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="268" mass="29440" checksum="7F3DF03DE5E0F0AB" modified="2018-11-07" version="1">MEPINDADVTASSTAALHLPRILCLHGGGTNARIFATQCRSLVQLLKAEFRLVFAEAAFPSQAGPDVTVVYGDWKPFKRWMRWLPHHPAVGHDEAVGALDDSLREALRKDDLRGATGECVALLGFSQGAKMVASLLYRQQLRDEAGLLPPGTLRFRFGVIMAGSAPLVALDPSLCPRPGLPDASDISELKPCEPRVYVLRLPTIHVHGTLDPGLARHRRLVEEFCDPKTSAVVEWEGEHRLPLKQTDVAPIIGHIRRLARETGVYDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEH4</accession>
    <name>A0A367LEH4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEH4"/>
    <dbReference type="STRING" id="1330021.A0A367LEH4"/>
    <dbReference type="OrthoDB" id="2603at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="332" mass="36593" checksum="98DFAF316C6D3065" modified="2018-11-07" version="1">MNTTATYRMSTIITERQNVHRRNTFHPVDWPTLKQQWANEREWKNDVDSVSIWSDDVGDDDHRSDYGPREGIARMLTVYPVRDAAWITAVAFMLGGVAFTTAALFTLLPLLFPQLAFPGQQEVAFPAALTTGSAFFFIGGNLATLGAFNVGRGPEPADEAMIKKKSKYNPALLGSKEWVWFPPWSDFKANYLSNPAFRGGVIATTGGYVLTSATIIGFPGVLDDKAPDFLDQFKRFVMTPLLIGASFLGIGALVLTLVIQERWYKPAIFLVAWHSTFWNVVGAAFLAASAALTILGPGLELQSAIATTASSLSFITAASLQWYKLMEFYPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEP4</accession>
    <name>A0A367LEP4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_0613</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEP4"/>
    <dbReference type="STRING" id="1330021.A0A367LEP4"/>
    <dbReference type="OrthoDB" id="10020333at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14019">
        <property type="entry name" value="STKc_Cdc7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF23">
        <property type="entry name" value="CDC7 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="112"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="27"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI12702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="491" mass="55786" checksum="BBAC43A5030698E7" modified="2018-11-07" version="1">MTVTTFAQEEAFEIHEDVATEETVLMADDEEEPSCIEQDGSDDDDDEETEGADADDEQDQDEEAHEGDEGDEDCEAEGDDSTESSDDEQVESTVQADMDKLQQDFPGFRDKYRLIKRIGEGTFSTVFKAEDVHYGRYDNSWDLQDGPSKWTPPPLKNRPFPRRPRPRYVAVKKIYVTSSPARILNELELLHDLRQCPSVCPLITAFRHTDQVVAVLPYFRHGDFRSYFRDMTTADVAIYLRSLFTALRSVHAHKILHRDIKPTNFLYDPASQHGVLVDFGLAEREGSDFRPCLCHEAREIRKQRQSASVWIQSAVGAQLGYPKNDTRPSRRANRAGTRGFRAPEVLFKCTEQTTAIDIWSVGVVLLTILSKRFPFFNSADDVDAMIEIATIFGSKRMKAAGLLHGCVFETNIPTVGQQGFSLEKIILWSTCRSDDRPLTSDEKLAVRFLERCMDLDPSRRITAEQALDHDFLRIPDQALPDEDDEVDMLQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LF66</accession>
    <name>A0A367LF66_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LF66"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="321" mass="35954" checksum="01566F5B25E8A3DD" modified="2018-11-07" version="1" fragment="single">LPTAIHNRPQKAPSKRSLEDRYKAPIHPAGLVRLTHLPLGVHHLRRRLLLQPGRLGRKLPLLLLVNVVHVTRRRHARALALLVLLVLVLNQLLLLLEHLEPLLVGRRPLGVVHLELHLVEELLRYGGEDADEGVDLVPFRLRALPALLSTSSVDGTPSRSRRSSQVCRSVRIRAGDTLCVRIPRAAHAVCSSDTVKLSTPSKLMALSSRLICRIRCRTWYRSIMSVPNVLRFMYRHIDTSCGRERLSSVTSSRKTLQTRITSSRVGVSPVDRTLRKKLANSSLCAVAALRGRPVSLSVCLRNALTSLRVDRRRLALASFDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFE4</accession>
    <name>A0A367LFE4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0427</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFE4"/>
    <dbReference type="STRING" id="1330021.A0A367LFE4"/>
    <dbReference type="OrthoDB" id="1924260at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF12">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="581" mass="64430" checksum="E1C65A4ED7F01CF1" modified="2018-11-07" version="1" fragment="single">LWFCFHVRPTPLLPRLVSPALSSLLNLTTGLSLLVRQYEMAGPGGGPPRRSRNCTKHKIRCPYNDVQVPDADRSTTPDKPDLMWTPQIEAAIADWQTTGVFPLPSLGVYPAPISHLYSVEDLRLIYHVASLYHELASIDANNFTLWTRHIPTLLRIGATTPYVMHALLAFSAMHIAFLTDCPLVGSMAFEHRGVALSGLHEAIGSFSRDTSDAILAASLVLSWQATDWRSWTQLMQGTSTVIDAMDAWKHESQFGDFIAESSTFPTAPPSPGPDHRPSQPREEDLRASQRTLEQVQKVEAHLKRNKEETKQIQHLIGFLKGARKISPSLSIAAQYERLQPLRTWLFWMPVGYLQTQHGSPNSLVIIAHLYTVALLMERLFPEIGAAYFGSLSISPVEEIARRLMSISVSGGHDGRAQQQTPLTLMEFPIDTVAEFRNRMGWVHPERTPSFPQFHPPNFPVGESTEPQYAPYSNVSFSYSEHEMPVLNSASMPGLQQPPVSPSVLSSPFTHQQYLNVPSPSYAGGAYSPASSTFEGSVAYSDSEEYGSFGHAAYQSGQPSMLSEAHRSYGVGFVTPHQPVWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LG50</accession>
    <name>A0A367LG50_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cAMP-dependent protein kinase regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_1017</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Tetramer, composed of 2 regulatory (R) and 2 catalytic (C) subunits. In the presence of cAMP it dissociates into 2 active monomeric C subunits and an R dimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cAMP-dependent kinase regulatory chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LG50"/>
    <dbReference type="STRING" id="1330021.A0A367LG50"/>
    <dbReference type="OrthoDB" id="10264870at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070461">
        <property type="term" value="C:SAGA-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004862">
        <property type="term" value="F:cAMP-dependent protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034236">
        <property type="term" value="F:protein kinase A catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000039">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000006">
        <property type="entry name" value="cAMP-dependent protein kinase type I-alpha regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050503">
        <property type="entry name" value="cAMP-dep_PK_reg_su-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024738">
        <property type="entry name" value="Hfi1/Tada1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635:SF152">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12767">
        <property type="entry name" value="SAGA-Tad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0114">cAMP</keyword>
    <keyword evidence="4" id="KW-0116">cAMP-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="609"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="741"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="386"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="477"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="516"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="554"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI13367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="869" mass="94341" checksum="B8A3E46BBE018A8B" modified="2018-11-07" version="1">MPDIDPAALSRPVVTLSTPVLANKTLSINSAGSIKISKSQIIPSRIDLEPAYAPLKAAIGGEQWLLYKEAMAEFLTGRLSQAEYSDRIDSLLGGDNGDKDHLHNLLIAALLGNVTREMPDQGIAPWVSANDKPVVPVASKPVTGDAAERRLKGDVMQLPARDRRRIKDLTQMDWDPHDMLTNTLLEAHRRPTSVPEPPSSAVGSINKMNFDLEIRKRFAQPLAVESGEFPDVGLITGRMLPMCYDAGLAGGHSSEAPQLLSVATETFIKEMLTQIFSRTRSNGPGDSGCAGLSIGTTWIQTRKYQRQLRLEEEAAQRGEMTRDKNGLLPVEAKAAAERQQLGMADMRLSLELADSGMAQFPALRTQTMFGYRDGELENWDDYTWLGGKRPDPTEAGGGASREQQRAPNGHAEPMDVDGGDAWWDGTEVQDVDMLDSVLESCLTRNGPSFAAVGLTTTTTTITMSGIFSIFGSSINPFGGGEQGEHESSGMSRVEEEDEDNFPRASDPNITIRPDSPVSPTPLPPDPAAVTRPPPNLGADGAADDKPPTARKPPNTDNYPSNYNFSRRTSVSAESLKPNADSYDNWSPPKYEKTPEQLERLQRAIGSNFLFSHMEDEQSGLILGAMVEKPVPAKGIKVINQGDAGDFFYVVEKGSFDVHVNPAGAIQPGPDGMGAKVGNIQAGGSFGELALMYNAPRAATVISIEPSCTLWALDRITFRRILMESTFARRRMYESFLEEVPLLSTLTPYERSKIADALETKKFAPGEVIIKEGDPGHDFFLLESGEAAAYKGDTSNQVRQYKKGDFFGELALLNDAPRAASVAASTDVKVATLGKSAFQRLLGPVEGILRRTRYEDIETGVEGVDPLSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGD8</accession>
    <name>A0A367LGD8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Acyl carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L249_0636</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGD8"/>
    <dbReference type="STRING" id="1330021.A0A367LGD8"/>
    <dbReference type="OrthoDB" id="448946at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099128">
        <property type="term" value="C:mitochondrial [2Fe-2S] assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000035">
        <property type="term" value="F:acyl binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000003">
        <property type="entry name" value="Acyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002148">
        <property type="entry name" value="PRK00982.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="ACYL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863:SF28">
        <property type="entry name" value="ACYL CARRIER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Carrier" evidence="15">
        <location>
            <begin position="73"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCI13322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="152" mass="16286" checksum="E196181F9D23444F" modified="2018-11-07" version="1">MFRAAFVRAASAAARQRGGGGQQLLSSSLRPCTTTEATRSATMMAAAIPNVFLLRAFVGGHRLYSSEGGLPREQVEGRIMSLLQGFDKVNDVNNITPTAHFANDMGLDSLDAVEVVMAIEEEFSIEIPDKDADSIHSVDKAVDYILAQPDAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGJ8</accession>
    <name>A0A367LGJ8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5497</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGJ8"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI13540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="108" mass="12275" checksum="42053968707C3AB4" modified="2018-11-07" version="1" fragment="single">RPIDSLQRSSQRSARCTYSGHSTRLISAQGSRHIDRRAVLIAVIALDQSSQRDRHSDRRAVLIAVIAPDLDSRTKVRSLLLASTLLLLQYNHLSCLQFFFNYHKTTIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGU5</accession>
    <name>A0A367LGU5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5511</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGU5"/>
    <dbReference type="STRING" id="1330021.A0A367LGU5"/>
    <dbReference type="OrthoDB" id="4930473at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI13664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="130" mass="14947" checksum="9D2B6335250219CF" modified="2018-11-07" version="1" fragment="single">TRCKDIRTFSRKKGEFSAFLTNLKDKIRTNKAIFRDKEDRIGFLFRSLEGKARKTLKTRLLTKTKDNSLSYKDFCGYVKDSAVKRLDAELVLPNNLPALAKYSLSILLPKTPLLNRQIDPAVQANAERRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGX3</accession>
    <name>A0A367LGX3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_5572</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGX3"/>
    <dbReference type="STRING" id="1330021.A0A367LGX3"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF134">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="468"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="560"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="96"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI13649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="599" mass="65447" checksum="96E896EC3D323762" modified="2018-11-07" version="1">MPSQDSVTHEVGREQPMKEPDGPELGTSFSSSSEECTQVATVDAQSPIIHLHLTFDTILPMARRPIPGCGDALPPCPDLHRLRRPLYWSAARKYAILASSCVAVFLAAYAAAAYSPAAAVGMKELGTTPLVILLGTSTFCLGFGLGPMVLAPASETWGRYPIFIASAAVFVGCQALTPVIRNVAGVLAARFFVGVGASVFSIIGNGVIVDLWEEKDRNTPMALFAGFTMAGYSAGPLVATVLVRVIDQQSLLWKWIFWHQACVDAAVMTAFLFLYRESREAVVLANRARLLNKWYEELEGLGSYGVWISSADKACSLSASESSLGEANDLFADNGTSLGRVQRVRWVVVERPSVRRVMTTSILRPFYLLVMDPIVLFFSLWIAFAWGVLYLSFSVPPLLHQKDPDRSICAYGAMVAASAVGAGASITQQKLFENPQWSKHRDNACFRHTDSRFWAYVRRRFPADAPEARLYTTCITALFLPLGLLGAFVLPKYMGYAEAIGIGFAIWGIFSIYLASLNFLADAYGAYASSALASQNFCRNLIGGGFTLLTRVMLTNLGRQWMGIILGCIAVVLSVTPWVLVLFGKRLRSRSKFATSLQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LH53</accession>
    <name>A0A367LH53_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">IMP-specific 5'-nucleotidase 1</fullName>
            <ecNumber evidence="12">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_8176</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">IMP-specific 5'-nucleotidase involved in IMP (inositol monophosphate) degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>IMP + H2O = inosine + phosphate</text>
            <dbReference type="Rhea" id="RHEA:27718"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="3.1.3.99"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ISN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="12"/>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LH53"/>
    <dbReference type="STRING" id="1330021.A0A367LH53"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008253">
        <property type="term" value="F:5'-nucleotidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006190">
        <property type="term" value="P:inosine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071590">
        <property type="term" value="P:nicotinamide riboside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071592">
        <property type="term" value="P:nicotinic acid riboside biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009453">
        <property type="entry name" value="ISN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28213">
        <property type="entry name" value="IMP-SPECIFIC 5'-NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28213:SF1">
        <property type="entry name" value="IMP-SPECIFIC 5'-NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06437">
        <property type="entry name" value="ISN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028836">
        <property type="entry name" value="ISN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR028836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI13729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="422" mass="46613" checksum="C222A06646334BAD" modified="2018-11-07" version="1">MTTRYRVEYALKTHRRDQFIEWIKGLLAVPFVLCSGALTDEADVAKMADEAHRRYAEIMSDVESLIDDHIQRQSLPHPRPSKLSMLVPTAGPFFTRLPLGDAFTYQDGKRNISRRRYVAPSFNDVRLILNSAQLMAVTADGLELATFDGDVTLYEDGGSLDRDSEMVPRILSLMRRGVKIGIVTAAGYTTAEPYYHRLRGLLDALADDADLSKEDKEGNLVVMGGEANYLFAMDLSSPHKLVAVPSEEWKTPAMKPWRDEDIASLLDAAETALSDCVRNLRLPATVMRKPRAVGIIPDPAGARIARESLEETVLAVQRTLEVVTSRQKQAKDDNQSRASVPPFCAFNGGRDVFVDIGDKSWGVSVCQRWFGGRIGARNTLHVGDQFLSAGANDFRARSVGTTAWVASPAETVELVDELMGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHE1</accession>
    <name>A0A367LHE1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_8244</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHE1"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI13830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="59" mass="6531" checksum="7BC86A0B411C360D" modified="2018-11-07" version="1" fragment="single">VSFPDEGISSIVFGWCIVTHERSEESSRQGQFSRQILSGAEANVEYPAFKMASNVLKPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHR3</accession>
    <name>A0A367LHR3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHR3"/>
    <dbReference type="OrthoDB" id="4920124at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="747" mass="82657" checksum="FA72C8CE74A6AD69" modified="2018-11-07" version="1">MDSLGPRINPSLVSFMVAGNGAAEHDEAPVSTTPTPSDRLAALPLVIEGDADVDGFQKTPALSHNRARDFIARDFIDRVDTVLHGNFNSPASQLPPYPTVPLFGELLNPVVADEPGLSNCTPYMAWQQHNTTAHLVSPSPVAVPSVPPALGFPFLPCSFPDLPYDILPFAGHGWDASATWSPTSTPTQAVYEQRHGGAQATLGSYGRTNSSLRPNAQAFTPYSPTMTQPSTEVARQLLMSDPVQRPAMGGPSIGSLAGTLPARGMMLQPFYSQGPSMASYNPSETGSSHSHSTYISQPSSRSLGAPRYAATSMAKTNSTQSNRPLLPKHKATRFRQPPTPSLRSEDTNASPRPVDSFSSSGPRGKRYRSLSPNVRQSAKDRRDNRSVCVRCKLSSTACRPVEGASWCQKCQDQGTTSSCTVFYFMNMAESTRFTGIENHSISLPLLRDGKWRVIDFGQLLKHIERLGRPTVIRAVRDKQRLYDLDLGHCHRYLTEASNNLPPSYSIQSFVREQQEKQDWQTCVRIGNGFSKDAIGALAIFDDRPSETTFRLVHSHNRTERSFNPDNDHDRLGLLVAHVLSLTFGRQIEQAALAQLSRLLPKHQHMSYQELDFLAEQLLTIRWGVSLDFRRRAMLSLQPPSPSREAEMIRLEKRMKTDKTLCHKLYMCFCCLRHKREKRPLSAEGLLSFGDRTRRYAGTERAVAERLPKTDSWEAFEAWMADGRVAVEAAGVLERGGARGVRSLTPTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIT9</accession>
    <name>A0A367LIT9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_6045</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIT9"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="60" mass="6990" checksum="CE29DBF434346FC5" modified="2018-11-07" version="1" fragment="single">MLIILLSRYFSRYFKVPTCSTLTYLYTCSNLTDLIDLIDPIDPIDLTRYNRYNVPAIAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIV4</accession>
    <name>A0A367LIV4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_5930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIV4"/>
    <dbReference type="STRING" id="1330021.A0A367LIV4"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008142">
        <property type="term" value="F:oxysterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120009">
        <property type="term" value="P:intermembrane lipid transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000010">
        <property type="entry name" value="Oxysterol-binding protein homolog 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF184">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN HOMOLOG 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI14307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="417" mass="45518" checksum="D1F9F7C2B80B982F" modified="2018-11-07" version="1">MSSSGAAAPPGGSSSTWSAFLKSIASFNGDLSSLTAPPFILSSQSLTEFSSYWATHPSILTAPAAERDPAKRAVLVLKWFLSTLKHQYASRSEQFGNEKKPLNPFLGELFLGSWTDDTGETTLVSEQVSHHPPATAYCIRNRKTGVQLQGYNAQKATFKSTIIVKQIGHAVLTLPIGSGDEKHEERYVITLPSLHIEGLIFGTPFVELDGTSTIASSSGFTAKIDYSGRGWLSGKKNSVTAVVHPTDKEKDVLYNITGQWTKEFQIYQGPIKKNSTSTLVEVYDAAGTAQAELLVAPLEKQHPLESRRAWAKVAEAIQKGDMEAVSAEKGKIEQAQRNMRIKEKSENRAWERRYFSAVAGDDATLQELGKAVGVPLDGEQSKTGGLWRFDAEKAARADTQQLSGEDVKKLERELLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIW2</accession>
    <name>A0A367LIW2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIW2"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="59" mass="6225" checksum="CE791047D210E5E2" modified="2018-11-07" version="1" fragment="single">LQNLLYGRFDGFLDCTGPLSITIRTPTVSPGALSGGAADGAMLNEKGRRGTKEEDLQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJ11</accession>
    <name>A0A367LJ11_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJ11"/>
    <dbReference type="STRING" id="1330021.A0A367LJ11"/>
    <dbReference type="OrthoDB" id="4158841at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17242">
        <property type="entry name" value="DUF5315"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="275" mass="29900" checksum="D29E7706B294B990" modified="2018-11-07" version="1">MTEESEETAIPLSLDPRSKQQEPTPIIFSHPSRGTSHVSIPGALRQVDHGPALSSAKRESFTFERGSSSRLGAPGHSGSQRSGHAFQSAAVSRSTDRTDALWAEMQATLDEVELSASEDAHAFGTGHDRKLADLRSSQIALAQAWARSEADDAFETAIHKKFQLEQGDEGRSQGGTRQFASRLEAGEVKEMAKSSDNALSESSMSGGRDGLGSQLEEETELDILLAGKRREANDQYFERVNRGVIDVVAKLEDVATAMRAVEQESKDVWNETTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJ77</accession>
    <name>A0A367LJ77_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_6109</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
            <location evidence="2">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the CENP-W/WIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJ77"/>
    <dbReference type="STRING" id="1330021.A0A367LJ77"/>
    <dbReference type="OrthoDB" id="2543597at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13732">
        <property type="entry name" value="HFD_CENP-W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000075">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052484">
        <property type="entry name" value="CENP-W/WIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34832">
        <property type="entry name" value="CENTROMERE PROTEIN W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34832:SF1">
        <property type="entry name" value="CENTROMERE PROTEIN W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI14471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="78" mass="8673" checksum="D20F02C2DE993EDE" modified="2018-11-07" version="1">MALGKTPYPKATLKKTIKAHSSLNIKKNADVTIFLDYVLFMERLVKEAAIHSKLSGEKALTGRSVKRVTRDALARFKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJE9</accession>
    <name>A0A367LJE9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_6582</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJE9"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="123" mass="14502" checksum="5BAF790AF5663C40" modified="2018-11-07" version="1">MKMRHVFKLTCLHSYDFFLFSREDTPFFPYQPSNTSIHIITTDQTRPQTDTSISAALLPEMNYRILSFISTIFIPFHPFWKFQNRFVACGTPLFPPPSSRLIFDKQLEFALYLSLYSSRGFEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJS0</accession>
    <name>A0A367LJS0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJS0"/>
    <dbReference type="OrthoDB" id="4941404at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="67" mass="7528" checksum="62810EF0C6C8ECFF" modified="2018-11-07" version="1">MFDANNLKPTKTPWPSRYTIPYDWKEAEIAIELYSDASFADDKATRASTAGFVIFLAGGPIAWKSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LK13</accession>
    <name>A0A367LK13_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6915</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LK13"/>
    <dbReference type="OrthoDB" id="3599317at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="95" mass="10790" checksum="0B786F04B9DD8F40" modified="2018-11-07" version="1">MGYVRVLQVGTLKYLEKIISISFSHLLNTNTSPASNSSSIASFRPSRDSSSSSLSPRVRLSDSGYLYTFNQLFTAFLFLHRPTKYLIRFHFSNAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LK76</accession>
    <name>A0A367LK76_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_6473</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LK76"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053210">
        <property type="entry name" value="ANKRD12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056485">
        <property type="entry name" value="ARM_KRIT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056015">
        <property type="entry name" value="DUF7593"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24149:SF14">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24149">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24521">
        <property type="entry name" value="Ank_KRIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24513">
        <property type="entry name" value="DUF7593"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="413"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="446"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="KRIT1 ARM-repeats" evidence="4">
        <location>
            <begin position="551"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7593" evidence="3">
        <location>
            <begin position="1258"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="505"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="701"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1546"/>
            <end position="1573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="175"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="511"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="713"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="764"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="841"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="882"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="914"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="971"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1033"/>
            <end position="1250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24521"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI14800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1573" mass="178554" checksum="C9DE75178B26B8C9" modified="2018-11-07" version="1">MDAQNAIGSDQTSPSSTQPPPPPPPPPPPPPPPPPPPPTQLPPPPPPPPPPPPPPPPSTSLTSTADNAPHTDRDSDAETIVLPGKDDRSPSKARKVRQEDKSESDGDAPQPKPKPDDDKAAPAVAPDNHHYLLPDAASKKHLLAPDKDRHARIKDGGSGGLSSAPASPSANQPYHHPHQQHPPQHQHLHSYHYSQQSRRRRSDAAASSPSDSEQLRSSSSKILPRNKLNKPDRPAVPHKRKAPKTESDDDADHRKVRRQRTASVHLDGSMLPKDARSTSAKSPHDHRPRSISPPPPPPRQHRRSISTQLPLPSPNGLNLKKKRLPPPLQSTDYHSDDSSVGGSPRPRSSKIRSLATPAAIDASTSPAKMGPHKKHLDAHGQTLLARACARGEYETAKQRLQERPEDLNVADYAGNTPLQIAAINGCEDIVKLLIDAGCNLDCVNYDKDTPLLDAVDNGHLGVVNLLLEAGVNPRKANVNGEEPLDRVSDDTDNAAEIRAVLMAARKRAGERRRTSEDRHSHQDSHDSHAPDSPHRSPTALPAAAATGRRSGTVRSTKTRNDLLYMPLDDKTLRQAAGRGDEETVARILQVKEGYDDPESMVAAARGGHDLVIQLLLGLGGANADPGPVESLPSEFATPILAAIGQENIKVVELLLKQQDFDPTRRFKGETYYEIARRRQGTNWKEEEQMLRNSYDDYRRLQKDLVKTKSPTGLRERDKDRDERSSKRDEPKESSSKSQKRNVSSPPQDADARKKVSGTRVTSPQEKKRPDLLTSRRGEDEMSKRAPARAKKQQSVHTSDHETASVLPPKPAKARRTGSDVTGMSSEGEAAKPRRKLISKGELSKERDRQKRAHKEPPSPREPRNDESSADKSKLLKKHHDRTKALKRDRSRDHSPGDGPTKRHRTSLTPDQPNDGDRDHHQTDGPTKRRRLDGEAHPEKRSNRTSSLDDRPRKPGQPRDVTARPTASGSKKNRDDVSKDSHDQRNTMQHGHARVGNVVHVKSEDVDVPMLGVKTPVDNPASDEPAPDQQGAEQTRRRGLVEHEAKREEDRKRLETEEKERKLEEIEKKKLEEVEKRKKFEEAEKKRKVEEAEKKKKLEEAEKKRKLEEAETKKKLEEAERKKRLEEEEKKKREEEEEKKRREEERARKAEEERKRRERAERERREAEEAARRQEEEKRRLEEKKKREEEEQRRRDEEERLRKEQLEREAAEEARRQREEEERKERERRERAHREELERKRAAREAEQKRIHEEQEKIRLDKLPGLLRWLDLCPNPKMPTYADKFKKMLGPRYDTICPGYDGTAAGREQWVLNTHVALLLGEKDLDLSRYTAWERTPVNRLSKLSMWRSEWPFWSLRSDEFWDFGRQIPGYYEKDPKDMDHDAFERLRLAGWERFRDMDMFFVKVSDLMYTVPNIPHLRNIRLAVQYRELQEHEEQGIRTYFKHRRDPGAERYFGFAPRCRYYVNGVFQGEDLPSDVQTSKTPFPEVRVPRRGLVRVYPNEPDYEEICKKQGLEHLLNKEEPATPALPNGAQLSPVSQTAAVPPVKASLVNGTSGHPADEGTTNGVTMEGIEGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKR9</accession>
    <name>A0A367LKR9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-phytase</fullName>
            <ecNumber evidence="2">3.1.3.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_6865</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.8" evidence="2"/>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKR9"/>
    <dbReference type="STRING" id="1330021.A0A367LKR9"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016158">
        <property type="term" value="F:inositol hexakisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF43">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00778">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="15"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI15025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="588" mass="64250" checksum="0E97A01A601EB1C3" modified="2018-11-07" version="1">MTAAAPIGPWQKQAVPVYQPVHQSQDDEAIPVPPGPGPGPDDPSATERHLRLAVYLLASCLGLLAAYNLFQLYPAADNGTATCPCKPSKVPQYFQTSPELWAGPTATGSPAFLAETMSWSPTGAYVPNQPLQTAVPVDGMAPTDQSIFRLMGYLSPYAPSPGFGVDEYPLPDGAEIIQLQMLSRHGSRYPTGDSKVENLGRRIANASADFTPKGPLAFLKHWKYQLGAEILVPNGRQELFQSGILHSYMYGALYNPKSKIITQDRMLKSAENWLAGFFGLEWLANNATIEVIIEQDGFNNSLSGTLNCPNAYPKSTGADARDAWARTYLKNATARFQNLTEGFVWSADDVYSAQTMCPYETVAYGSSQFCGLFTYEEWKAFAYSIDLYFAGSSAFHSPTGRAVGLGYQQEMMARLKNHTLGYSGSQINVTLDSSTETFPLNQSLYLDFSHDTNIASILTALGLVQFAEDLPLTGPPAEDRTFNVGHITPFGARLDMEIIKTPRPVSPARDGYLQGGETRYVHFVLNQRTLPLGKSFPECDAGRKDGWCELGAFLNVQEGMAARAKFDHACFGDYPRLPYGEVKDGAPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKW5</accession>
    <name>A0A367LKW5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cystathionine beta-lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_6801</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKW5"/>
    <dbReference type="STRING" id="1330021.A0A367LKW5"/>
    <dbReference type="OrthoDB" id="3512640at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000072">
        <property type="entry name" value="Putative cystathionine beta-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000066">
        <property type="entry name" value="Putative cystathionine beta-lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808:SF35">
        <property type="entry name" value="CYSTATHIONINE GAMMA-SYNTHASE (AFU_ORTHOLOGUE AFUA_7G01590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11808">
        <property type="entry name" value="TRANS-SULFURATION ENZYME FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="3">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI15068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="395" mass="43153" checksum="D26CFAED4311B453" modified="2018-11-07" version="1">METNEPGRRLSLASRAVHADDHVAAHRAVAPAMHVSTTFRYTDDPDRLDPEDVVDPSAPLDSHVYSRESAPNTARLEAVLSSVLGGQAITYGSGLAAFHALLVRINPRRIAIGEGYHGCHGVIDLLSRLTGLRRLPLDCGPDELGPGDVIHVETPLNPVGEARNLEMYAKRAREVGAYLTVDATFAPPPLQDPFGLGADVVMHSGTKYLGGHSDMLCGVLAVRPGLDWMSDLRHDRTVLGCVMGSFEGWLGLRSMRTLELRVLRQSETTQSLVSWLTKEMSDSSTAAGALVQRVHHASLQPEASEPDSWLRKQMPRGYGAVFAMLMRDEHSARRLPSRLGLFAHATSLGGVESLIEWRAMSDPTVDRRLLRLSIGVEALEDLREDLKRGLESLMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLD7</accession>
    <name>A0A367LLD7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Methylthioribulose-1-phosphate dehydratase</fullName>
            <shortName evidence="7">MTRu-1-P dehydratase</shortName>
            <ecNumber evidence="7">4.2.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">MDE1</name>
        <name evidence="10" type="ORF">L249_6809</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5-(methylsulfanyl)-D-ribulose 1-phosphate = 5-methylsulfanyl-2,3-dioxopentyl phosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:15549"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58548"/>
            <dbReference type="ChEBI" id="CHEBI:58828"/>
            <dbReference type="EC" id="4.2.1.109"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose 1-phosphate: step 2/6.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the aldolase class II family. MtnB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.109" evidence="7"/>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLD7"/>
    <dbReference type="STRING" id="1330021.A0A367LLD7"/>
    <dbReference type="OrthoDB" id="191080at2759"/>
    <dbReference type="UniPathway" id="UPA00904">
        <property type="reaction ID" value="UER00875"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046570">
        <property type="term" value="F:methylthioribulose 1-phosphate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019509">
        <property type="term" value="P:L-methionine salvage from methylthioadenosine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000003">
        <property type="entry name" value="Methylthioribulose-1-phosphate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03116">
        <property type="entry name" value="Salvage_MtnB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017714">
        <property type="entry name" value="MethylthioRu-1-P_deHdtase_MtnB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027514">
        <property type="entry name" value="Salvage_MtnB_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03328">
        <property type="entry name" value="salvage_mtnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640">
        <property type="entry name" value="METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10640:SF7">
        <property type="entry name" value="METHYLTHIORIBULOSE-1-PHOSPHATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0486">Methionine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="9">
        <location>
            <begin position="38"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="152"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI15072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="268" mass="29512" checksum="655981ADD0ABE927" modified="2018-11-07" version="1">MTTMTPPSASSSGPDPPPDPASDPDQLITSHDPHHPANLIPALCAKFWTLGWVTGTGGGCSIRQDDLVYIAPSGVQKELMKNTDIYVLSLSQRTYLRSPPRLKPSQCTPLFLAAFTRRRAGCCIHTHSQSAVLVTLLLEAQGSDLFEINNIEQIKAFPSEASSSSVVPDHHQPAAPNLGFHDTLTIPVIENTPHEEDLTSFLEDAMDRYPDTCAVLVRRHGVYVWGDDVRKAKTQAESLDYLFQLAVEMKKLAIPWISQITRIGPHRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLT3</accession>
    <name>A0A367LLT3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase F(0) complex subunit e, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_6756</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Subunit e, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase e subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLT3"/>
    <dbReference type="STRING" id="1330021.A0A367LLT3"/>
    <dbReference type="OrthoDB" id="2125027at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008386">
        <property type="entry name" value="ATP_synth_F0_esu_mt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05680">
        <property type="entry name" value="ATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4 11" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI15369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="92" mass="10477" checksum="3F9C37B7CB44EDB7" modified="2018-11-07" version="1">MSSTGVNVLRWSALAVGVFYGFSHQRTIRATQRAEHEKHDYEHKQKLIDQAKAEFARQKSPQPVSADDVITDVSDPRFDLEKLLLKVAKENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMW4</accession>
    <name>A0A367LMW4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3607</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMW4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="113" mass="12226" checksum="DA36F4D83C452993" modified="2018-11-07" version="1" fragment="single">ELPAAPVPSVLRDPGRTYYLPSKTCAQQDKRRFARKYAVAKRETKRKEDKTAAMAASPLCLSTSPVAVALAYAGSGRVCVRIRPEKAHASVASSSPPLWMSRQTRSGSVPARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LN25</accession>
    <name>A0A367LN25_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Endo-1,3-beta-glucanase btgC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Laminarinase btgC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">L249_1708</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation. Active on laminarin and lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="4"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LN25"/>
    <dbReference type="STRING" id="1330021.A0A367LN25"/>
    <dbReference type="OrthoDB" id="68336at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000151">
        <property type="entry name" value="Glucan endo-1,3-beta-glucosidase btgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF17">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE BTGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="310"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="136"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00042373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00043078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RCI15845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="674" mass="74533" checksum="DF626E4DE9BDA177" modified="2018-11-07" version="1">MQRNPDHDGYESYPLDHSSDRSRHHLGHNQAYRDNAPVSPYYDDALGQHLVDSSSSTSSRSRHYHDRYQQQQTAPAMHHHDFEEAPVPPLHGNAAYYNRHNRGAGDVLAVPTAGVTAASFPYNVADYNGTEVEPEFYHSSATIPPPPSRALYSDPSRPQHYTGNPYDTHNNRGPDQDSYSALNPFGTPSASHSPSRSVNSFGRPDSYGDDPYQAYPSNPRHEGVDLGLVDPHDIEDDGDDGLSYTKRPQRTSFFAAPSLDRAGGKSSIGAAAASSSAFAVKGHGFGASPGPEKPSAWLSEQTGGSKKWKWITIIIVFLVIVGAIVGGVVGSLVSGNRRKENSKSAADDTKENGDLNINSGEIKALLNNPNLKRVFPGMDYTPYKTQYPNCVDDPPSQNNVTRDVAVLSQLTNKIRLYGTDCNQTEMVIHAVRQLKMEKDIKIWLGVWQDGNQTTNSRQLNQMWNILDQYGADPFEGIIVANEILFRKEMTINTLASVLSDTRNKLASKNIKLPVATSDLGDDWTAELAQDSDYVMANIHPFFAGVSAAEAAAWTWNFWEGKDGPFWKSDKNRNVIAETGWPSAGGKNCGQAQTTTCEPGSVAGIPEMNHFMQDWVCDALKNGTQYFWFEAFDEPWKIRFNEKGKEWEDKWGLLDTNRKLKDGIKIPDCGGKRVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNS0</accession>
    <name>A0A367LNS0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">General transcription and DNA repair factor IIH subunit TFB4</fullName>
            <shortName evidence="14">TFIIH subunit TFB4</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 14">RNA polymerase II transcription factor B subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L249_2319</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 14">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Component of the 7-subunit TFIIH core complex composed of XPB/SSL2, XPD/RAD3, SSL1, TFB1, TFB2, TFB4 and TFB5, which is active in NER. The core complex associates with the 3-subunit CTD-kinase module TFIIK composed of CCL1, KIN28 and TFB3 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the TFB4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNS0"/>
    <dbReference type="STRING" id="1330021.A0A367LNS0"/>
    <dbReference type="OrthoDB" id="17307at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004600">
        <property type="entry name" value="TFIIH_Tfb4/GTF2H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12831:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12831">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIH TFIIH , POLYPEPTIDE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03850">
        <property type="entry name" value="Tfb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 14" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="81"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="324"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU368090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCI16037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="367" mass="39212" checksum="46639091193B9A49" modified="2018-11-07" version="1">MDAVDVSDRYEVAAIDEKPSLLVVVLDTNPHAWADLDDRLPLGKAVANLLVFVNAHLACSSANQAAVVAAHVKRAVWLYPPPPPPPPPPPPSRPTDASGDVPMNDAQPPPPSTASKYHHFGNIETTVMSSIRRLINETTIQDLDAWTTRLAGALKLALCYLNKTAEALGSNASSLAYHAKAHGINAQPIKSRILVISVSDSDPSEYISTMNAANAAARVQVTIDTLSLAGEATFLQQACFTTDGHFLAASKPQGLLSYLMYGFIADTEARKLLFTPNHYKIDSRAACRCHNRVLDKGLLCTICLTTFCEPPPGLECLICGTKLEPGKEGEKPAVVPKKKRKRTKKTAATGTGSGREETGSATVTVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LP11</accession>
    <name>A0A367LP11_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_3027</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LP11"/>
    <dbReference type="STRING" id="1330021.A0A367LP11"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18583">
        <property type="entry name" value="ABC_6TM_HMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000287">
        <property type="entry name" value="Multidrug ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF503">
        <property type="entry name" value="MITOCHONDRIAL POTASSIUM CHANNEL ATP-BINDING SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="48"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="487"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="267"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="582"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="193"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="820"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="203"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="830"/>
            <end position="845"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI15982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="845" mass="93488" checksum="F082810C51396F32" modified="2018-11-07" version="1">MDKAALLEGLYVAFAIIVLFFVFVSFLLHYGRSSFSPDAVLRKAPLRLIAVGLVSLLFTAELVLVALRRRAVNQNEDRIVACALSALAWFAVSFRNAYLTVEVVGLSLSGLVFGIPLLVIEAILRKDPTVGSDRHWTLLGTQALRLLLLLSLFADAGLRVCVRRRKMRTKSDASDEARPFLRAANGEAPAEASYGSVSHAGSDDGSSCVSDWSSDSGSDADADETPKDSETGQLRKSGSWIVYVRNFSIFIPYIIPRKDYKVQACIVTCLVCMIGDRFLNIMVPRQIGIVADKLVQGEAPYPELVLYLVLSLAQGDSGLELIQALAKIPIEQFSYRQITNAAFNHVMSLGMDFHSDRDSAEVMKAIEQGEALTNVVKTAFLDIMPTLIDMVVAFVFLYIKFSSAVALCMMIASLSFLVVEVISSTWNIENRRRSTKTERREARVMHQAVQGWQTVSAFNMFSYERFRFAAAVDRHLEAKLDWMRRDAFIQALLQALVPSTFFLLAVLVIRQIRDGHASPGDFVFLISYWDYLILPIKYLSHEYRFLMSDLIDAERLLDLLLAKPDVTDKEGAPALGQVEGRVEFDHVEFAYDARRQALRDINFAVRPGETVALVGSTGSGKSSIVKLLMRYYDVNSGSIRIDGKDIRDVTQGSLRNALGVVPQTPLLFNATIMENLRYAKLSASDEEVFDACRAAAIHDKIVAFPDGYETNVGESGVRLSGGEVQRLAIARAFLKNPPILILDEATSAVDTETEAEIQEALGRLSVKRTTFVIAHRLSTIINADLILVLQDGEIVERGTHDELLDKGGRYDALWHKQLGGSHVSENGSESGDESGEEEPLIDTTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LP92</accession>
    <name>A0A367LP92_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LP92"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="78" mass="7759" checksum="74B1E530AB53B08E" modified="2018-11-07" version="1">MLGARGPIGPAWLLPPSYPRGAGGSARGAGGGRGNDNGDDENSGDKGDDNNANDEEEEGAARRSASNADEAPPRPGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPN2</accession>
    <name>A0A367LPN2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L249_2866</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LPN2"/>
    <dbReference type="OrthoDB" id="300780at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000111">
        <property type="term" value="C:nucleotide-excision repair factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071942">
        <property type="term" value="C:XPC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20339">
        <property type="entry name" value="BRcat_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20353">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16630">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2460:FF:000001">
        <property type="entry name" value="DNA repair protein Rad4 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.20.110">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2460">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018327">
        <property type="entry name" value="BHD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047545">
        <property type="entry name" value="BRcat_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004583">
        <property type="entry name" value="DNA_repair_Rad4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018325">
        <property type="entry name" value="Rad4/PNGase_transGLS-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018326">
        <property type="entry name" value="Rad4_beta-hairpin_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018328">
        <property type="entry name" value="Rad4_beta-hairpin_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042488">
        <property type="entry name" value="Rad4_BHD3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047546">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047544">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057358">
        <property type="entry name" value="UBL_ZFAND1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135:SF2">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135">
        <property type="entry name" value="DNA REPAIR PROTEIN XP-C / RAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10403">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10404">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10405">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03835">
        <property type="entry name" value="Rad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26200">
        <property type="entry name" value="Rcat_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25327">
        <property type="entry name" value="UBL_ZFAND1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01030">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01031">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01032">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="15">
        <location>
            <begin position="23"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="AN1-type" evidence="15">
        <location>
            <begin position="85"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="16">
        <location>
            <begin position="1389"/>
            <end position="1611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="289"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="512"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="689"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="877"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1103"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="309"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="347"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="395"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="519"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="701"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="723"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCI16403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="19">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1938" mass="216210" checksum="5A18FBEF9A27894A" modified="2018-11-07" version="1" fragment="single">GLDLDDEAVAACISGKDDMIDASLVGKHCQYAPCNLLDFLPFRCQACLKDFCADHRIPSSHECTASTKPVQRLSHHNTATNKPKSVTEKACDSPACKAVIGTPLTPSIHCRTCRRDYCLKHRLQEEHNCNALVAAAKGHDEAAEKKQSALDRLRAWSVARMRHTSRGSEGKAKSGYVASQIAARNLLKRNAKGRADVPENMRVYLHVEAEPNPGQEQLLKGDFFYHKDWVVGKVLDDAAKSLQITNINNRTTDERQRLRIFHIEGGRMLDFSEKIGTVTESGNTIALLRGVGPSPALMEPSRVLRKRPRESQQTDSKDKGKATPSTPAPARKRPKTSLYDDLDASVTPRSSKEFGSTTLGFDLEDSDSSLTSLSDLELQEVPTKGTRSKARVSEDGGDSDDDDDDEDIEFEDVVAAPAAATESAPVVSGDLELTLQKDTRVSLINLYGDKRGPTKRERKVRNATHCVHVMLLLWHNAVRNSWLCDSEVQATMLSHVPPRIWNDVERWRRSSALGSPIEATKTTTKGKAGASEDSSRDWGSKAKKLEEGAVDMSRGDPLFRLMQSLVAWWKQRFRVTTPGLRKRGYMALERLDRLTKAFLMESGDGALFGEKISSLEAFRDRARACEGSRDVGAQLFTALLRGLGLDARMVANLPCLGFGWSKLEDADPEKEEPVVKKPEGMPGVTKAAEKAATKKVKPQQAPKTRSTRATRQTAPVATDSEDELRIEGAKSGEEDDDEPVAKMKLPITPHRATLDKDLEYPHYWTEVLSPVTNRYLAVDAVVKGIIATNRDLVESFEPRGAKADRARQVMAYLVGYSQDGTAKDVTVRYLKRRVMPGRSKGVRMPPEKVAVYDRHGKVKRYELLDWFKTAMSGYRRGDRRHPLTEADHEEDATDLKPGEAAKKDVKEGSETLQYYKQSSEFVLERHLKREEALRVGAAPVKTFKNKVKGGKVEEEDVFLRTDVVQVKSSETWHKQGRAPKAGEQPLKRVPYRAATLNRKREIYEVEAATGEKVLQGLFGLEQTDWIIPPPIKDGVIPKNEYGNIDLFAEHMCPEGAVHIPYRGAVRVCKRLEVDFAEAVVGFEFGNRMAVPVIQGVVVAVEHRERVMEELARDEAERARREDEKRRKAALGQWRRFMMGLRIAERIRLDYGDLEATTPHVARLPSFQAFQHYIMDEDEETPSPNFDACMAQVKDVLPAICPNFLAEQVRRHGLDANAVLNAIVELESQGKTYPRRPKAKDLKRKHDGGDGYGDDEVEAAIRRCHRTSVAAGRKPRWRSRKDLHRIRQLLERDYPEVDSQTINHTIKAAENLFLPAYLKLYQAGQKPVSTVQRPDGTVESRNMNDSTRQCQDSDERALLKELQAARAIVNAQERKRQSEAEKVAAWAEGLVKECQCCFSEVAINCLVECNAEEPHCFCVDCCRHQAETLVGLCKHEIKCMSTEDCTEGFSRSERQKFLDTRLAATLDRLEQEESIRLAKIDGMITCPFCPFAAECGPVEENKEFRCQNPDCQIISCRLCQGESHVPLSCQEEAKKRGFSARRTIEEAMSAAVIRRCNKCSTPFIKESGCNKMTCTLSSCRNVQCYVCSKSCDYSHFDDTNRGGKIGNCPLFDVVDSRHAQDMWDAEQNTRKKVVEENPDMDPSLLDFHMSDEVFAKERLLAQSSRINPRDKENLQKVRARYAHPAGAPLVGEDVGPPHPPPHDFFFAPRGYAMPQQYPHQPIRHPHIDAVPGPAPHVGPQPPPWRMVSRRLFASVARLTRDALDAHRAHNAQQHALMDRRAAMTGHGAQGARQVTADDAVPPGMAANVPQAVTMPQWPNINLQARQGIAGDGPPGMVANMPQAASIPQLPNFNLQARQGIASHVSPGMVLANMPQAASMSLQQPFNLGAPNPNLLEGAMGGELPGPGNFDSPLQIMGGNLNVYRNLNVYRNVNGQRRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQ22</accession>
    <name>A0A367LQ22_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">L249_2649</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LQ22"/>
    <dbReference type="OrthoDB" id="2015534at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009584">
        <property type="term" value="P:detection of visible light"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000048">
        <property type="entry name" value="Sensor histidine kinase/response regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.270:FF:000002">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013654">
        <property type="entry name" value="PAS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016132">
        <property type="entry name" value="Phyto_chromo_attachment"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001294">
        <property type="entry name" value="Phytochrome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013515">
        <property type="entry name" value="Phytochrome_cen-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043150">
        <property type="entry name" value="Phytochrome_PHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43065:SF10">
        <property type="entry name" value="PEROXIDE STRESS-ACTIVATED HISTIDINE KINASE MAK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43065">
        <property type="entry name" value="SENSOR HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08446">
        <property type="entry name" value="PAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00360">
        <property type="entry name" value="PHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01033">
        <property type="entry name" value="PHYTOCHROME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50046">
        <property type="entry name" value="PHYTOCHROME_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0157">Chromophore</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="2" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="PAS" evidence="17">
        <location>
            <begin position="279"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Phytochrome chromophore attachment site" evidence="14">
        <location>
            <begin position="456"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="15">
        <location>
            <begin position="832"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="16">
        <location>
            <begin position="1279"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="125"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="181"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1069"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1124"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1170"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1253"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1437"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1124"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1184"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1216"/>
            <end position="1226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RCI16536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1458" mass="160123" checksum="0CE7E32765C5F20B" modified="2018-11-07" version="1">MAGRQSPEAESIGATPRRGTRSIPFSPGDSTFSRSPPTATDLDSQRQRQQQLVTSPDPVSSWSTTSERHLCTRSAASDISADRVFPIRSVVSVAPTPRRPSNSVDDYFTLPADVDASNNPLRRLRDRRQTTFSSDLQRIDSTEANSGGNIPWPRRKRPLSGPLSSIQADAARKGTISPLNLAISTSDDGSDDESAPRAPRSATARFASDPDRGCPSAASGNRSLSDVPHVTTRFTHVQTEGGHSVITGRDGVLQRCEDEPIHTPGAIQGFGVLIALREENDGSFIVRYASENSEKILGYRPKQLFELDNFMDILTEEQQDNLLDHIDFIRDEDADPSANGPEVLSLSIRHPKRRRSVKLWCAIHINPAHPDLIICEVERDDDQEYPLRPTDELTPDVPHDTLHSNPNLEEIEESTEVLSKPLRILRSARKRRGEQGAMQVFDIMSQVQEQLASAQNLDTFLKILVGIFKELTGFHRVMIYQFDSAFNGKVVTELVDTAQTLDLYKGLHFPASDIPRQARDLYRINKVRLLYDRDLETARIVCRTAEDLETPLDMTHAYLRAMSPIHLKYLGNMAVRSSMSISINAFDELWGLIACHSYGSHGMRVSFPIRKMCRLVGDTASRNIERLSYASRLQARKLINTAPTDSNPTGYIIASSDDLLKLFDADFGLLSIKGETKVLGALEQSQEALAMLEYLRMRRLTAVVTSQDIAEDFPDLVYPPGFQIVAGLLYVPLSVGGHDFIVFFRRGQVKEVKWAGNPYEKTIRQGTSGYLEPRSSFKTWRETVVGKCREWNEEQVETAAVLCLVYGKFIEVWRQKEEALQNSKLTRLLLANSAHEVRTPLNAIINYLEIALEGTLDQETRENLARSHSASKSLIYVINDLLDLTKTEEGQNLIKDEVFDLVACLREAIEPFQNDARRKSIGFSVSHDPGLPRLVHGDGRRVRQAIANVTANAVAHTQSGSVDVEMLVVEVRDGQAIVEIVVTDSGVGMNPQQLDALFRELEQVSGEGPEPQSPADQEKAYGARTLGLGLALVARIVRNMDGQLRLKSEKGQGSRFVVQLPFLLADDSPDISGEGSSAVRDASEPPNQVLSTVGPLKPTPEGEILLVDGQRTLGVTVEGSVVVVPDDASGGSRRSMGSRGSHGSDADRLINAIQTPLSLNENPAGYFGGAPGSGCSSGRGAPRTSFSGPPLSTSPTTRKLAALTTSTASRQEPGTEEIRDSKTPLRAVKVPDEYKTVAEAPLDEKPSVVHDVAKSGGRHGLRSRSIVSGTTTDGGNGLRTLVAEDDPINMKLLSKRLEKAGHEVRHAVNGEDCATVYKDDSPSFDANCMYYQMPIVDGLASTKMIRSIEGTTEHKGYSALASLNGRVPIFAVSASLVEREKQTYIDAGFDGWILKPIDFKRLNTLLQGIYDGQVRSMCLYVEGQWERGGWFIMPSVESAGETSEDTTPRAEKPVSSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQ82</accession>
    <name>A0A367LQ82_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2418</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQ82"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="184" mass="19813" checksum="A96DAAC523979801" modified="2018-11-07" version="1">MPLPCLMFAVGYRAPSPPLLLAYGLSTNRWDDGLGGGLGSGWRGPLKSRPQVVGPCVQRGGDEMGWDGPGHGHFLKQKSNRTSIIARGGAPTPTAQLPGWTRRRTAQARNRTADNKRIGRARTATGRHRIDRAAPGREAQAEKQATTGSKKNINGGQAAVRSKGEEAENLSWPQWPAGEDSERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQI9</accession>
    <name>A0A367LQI9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Essential protein Yae1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_2001</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LTO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQI9"/>
    <dbReference type="STRING" id="1330021.A0A367LQI9"/>
    <dbReference type="OrthoDB" id="48036at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019191">
        <property type="entry name" value="Essential_protein_Yae1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052436">
        <property type="entry name" value="LTO1_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28532">
        <property type="entry name" value="GEO13458P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28532:SF1">
        <property type="entry name" value="ORAL CANCER OVEREXPRESSED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09811">
        <property type="entry name" value="Yae1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Essential protein Yae1 N-terminal" evidence="3">
        <location>
            <begin position="19"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="63"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI16688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="160" mass="17796" checksum="09CF50E102490981" modified="2018-11-07" version="1">MSDPLEDVLHLEDRFYREGYQQGLDDGAKAGRVEGRCFGMEKGFEKFLEGGRLAGKAIVWANRLPSQGDEDDGNDDAVTDRETETCRGDKDQPHKTGPPTRCALPPLPDRNRIDKHVRALYALVEPGTLSTENTDEAVQNFDNRIKRAQGKAKVVERIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQX1</accession>
    <name>A0A367LQX1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_3030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQX1"/>
    <dbReference type="OrthoDB" id="10554251at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="397"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="61"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="650"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="552"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="650"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI16846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="797" mass="90885" checksum="BBE7CBA6DC23BEA4" modified="2018-11-07" version="1">MGSSEDANIDIVLACMNVDEDWGRDGREENLPGTREWSTTWHDRTRELHIEKEVVPVIILPGPTAPTSKHPTTTTTTTTTTTTTTTTTTTNDIEDQSSSALSKKKDIRPAPTGYSGTYIWVGKGLMLLFLPPLPPRESFCRRPPGFPLCHARALAPKSLPVSCLHGMICNHFHYLDMLTCYVVVITSTSQTSSSSLCFNNITWQESTKSIHIKQRQRFYTEISPVAATAAAIDFLENPFLSFPAPANSATTNSRLLPRFSPQNSSSFLILHISPPFFFNHHLSHQIHSCISVTLDIYDSHINQLYCHTHHQLLPSPSSSTSTVTPILDFYRHPHHQLPFRHLPHHHFRPSPIILNLYRHPHHHLLFYLHPHPPLYPPSLPMAVMQFIGSIQEVLQSLWVVFAFFWNMFFFSWTFFVLGFATFIFDVFRTVGLNLTAIIVIAVCCLWSQRTLLKSCTIEVLKSLLHSLEPPAQKPVGADKPPVVQTVKGPALCTERASKCEQVRFLYRTVRSELATSKDFYYGRFLDQYRAREEADHKNSRTQAEFATKEARIVELEGQISKADARIVKLEAGTAELKARIAELEMDEKASEAHIVGLEFQIQQLENKQEEDRLKTEKRMKSMAAAHKAALAARDDAVRRKKAEFERRLKKEQGSNRELREALSAQEKKASQVRTNFEHRMRRKTREMGTLLECIQLAEELKRELDEYRYHVGPLTSTQRPSRRRKCSSPTARYQLFRSQLRLGSGSNGSSIGLDDPMPDMSWLEGRIKPRGDMYIHRYSTDEDGRDHPDYSTVIVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LR48</accession>
    <name>A0A367LR48_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_3052</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LR48"/>
    <dbReference type="STRING" id="1330021.A0A367LR48"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.410.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF152">
        <property type="entry name" value="OXIDASE (CODA), PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04090)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="264"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI16926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="545" mass="60023" checksum="C4E40A341CD7AA20" modified="2018-11-07" version="1">MTTKTLPSDAVDAFDYIIVGGGTAGCVIASRLSSYLPQRRVLLIEAGPSDFRLNNVLDLRNWLSLLGGELDYDYGTTEQPMGNSHIRHSRAKVLGGCSSHNTLISFRPFRHDMDRWVAQGCRGWDFDTMVRLVDGLRNTIQPVHARHRNQLCKDWVQSCATALDVPVIADFNAEIRAKGRLTQGAGFFSVSYNPDDGRRSSASVAYIHPMLRGEERRPNLTVLTDAHVSRVLVDKAVATGVVVELASGERLRLRPRRETVLCAGAVDTPRLMLHSGLGPRAQLEELGIPVVADLAGVGENLIDHPESIIMWELNKPVPANQTTMDSDAGLFLRREVADAAGGDGDAADIMMHCYQIPFCLNTQRLGYPLVRDGYAFCMTPNIPRARSRGRLYLTSADPAVKPALDFRYFTDPEGYDAATLVAGIRAARRVAQQSPFRDWLVREVAPGPAVQSDEDISEYARRVAHTVYHPAGTTKMGDVTRDEYAVVDPELRVRGIGRLRIADAGIFPEMPSINPMVTVLAVGERAAELIAMNDGWKPDAKRSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LR54</accession>
    <name>A0A367LR54_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Formamidopyrimidine-DNA glycosylase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_2707</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine.</text>
            <dbReference type="EC" id="3.2.2.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LR54"/>
    <dbReference type="STRING" id="1330021.A0A367LR54"/>
    <dbReference type="OrthoDB" id="444592at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008534">
        <property type="term" value="F:oxidized purine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08972">
        <property type="entry name" value="PF_Nei_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.50:FF:000009">
        <property type="entry name" value="Formamidopyrimidine-DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.190.10">
        <property type="entry name" value="MutM-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012319">
        <property type="entry name" value="FPG_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035937">
        <property type="entry name" value="FPG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015886">
        <property type="entry name" value="H2TH_FPG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22993">
        <property type="entry name" value="FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22993:SF9">
        <property type="entry name" value="FORMAMIDOPYRIMIDINE-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01149">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06831">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00898">
        <property type="entry name" value="Fapy_DNA_glyco"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01232">
        <property type="entry name" value="H2TH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81624">
        <property type="entry name" value="N-terminal domain of MutM-like DNA repair proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51068">
        <property type="entry name" value="FPG_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Formamidopyrimidine-DNA glycosylase catalytic" evidence="11">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="293"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="312"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI16830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="374" mass="41543" checksum="D607E6FEBDE2A209" modified="2018-11-07" version="1">MNGAVVARIVHFLRLRLVGKRIASASAVDDANVFGKVGTSGAAVEAALKGNKVVSAGSQGKYFWITLEKPPHLLMHFGMTGWIHIRGEKTAYTNYYKKMKHHDLEAWPPKFCKFHLTTDENPAAEVAFTDPRRFARVRLMDCPGPDIRKHPPLADNGPDPVVDADVFTEPYLRTQMSRRHVPIKALLLDQATISGIGNWVADETLYQAKLHPEQYCDALDDEQAATLYRCVRYVCQTAVDLLGDSDRFPDHWLFNYRWGKGKGSAAKLPSGERLAFLTVGGRTSCYAPAVQRKTGGGVAASAKAVRGRSQDDSDDDDDDDDDDDDDDDDDDDDDDDKPIHSPPRKKKRAKTDEPTPKAPPAARRRSSRLQKSQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LR77</accession>
    <name>A0A367LR77_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_2694</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat NOL10/ENP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LR77"/>
    <dbReference type="STRING" id="1330021.A0A367LR77"/>
    <dbReference type="OrthoDB" id="273340at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056551">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040382">
        <property type="entry name" value="NOL10/Enp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056550">
        <property type="entry name" value="NOL10_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012580">
        <property type="entry name" value="NUC153"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23098">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23097">
        <property type="entry name" value="NOL10_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08159">
        <property type="entry name" value="NUC153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Nucleolar protein 10-like N-terminal" evidence="10">
        <location>
            <begin position="19"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="240"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleolar protein 10-like second" evidence="9">
        <location>
            <begin position="388"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="NUC153" evidence="8">
        <location>
            <begin position="495"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="514"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="529"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="542"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="570"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="632"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI16956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="644" mass="72788" checksum="607D70D69C5905AC" modified="2018-11-07" version="1">MKLTNPGAVSVYTISGASTARPLPDWLARRRKRSLKNDVEYQNRVELLQDFEFEEASTCIRVSEDGDWLMSTGTYKPQIHVHNLPQLSLSFSRHTTFLNHSFVLLSHDYSKSIHLQTDRRLEFHTPMGCHYQVRIPRYGRDLAYDRHATEALVPAVGLDADGKGEVFRMNLELGRFMRSYQVDVGGQGDEPGGGLQGSIAVGSVNVVSIAQDTHNLLAFGTSIGTVEFWDPRSKSRAAVLAGHDGELTSLDFGPSGLTLATGSSSGMIRLFDLRRPVPLLEKDHGYGFPVQKLIHMTTSSQEKKIMSADKRIIKLWDEHTGDPWTSIEPIVDINDVAWCRNTGMLLTANEGKQQHAFFVPQLGPAPKWCPFLDNMVEEMAEDVNVETYDNYKFLTLPELKQLSLAHLIGKTNLLRPYMHGYFVASKLYEQAKLIANPYAWEEERVKRVKEKVEKERASRIRGSKKVKVNQKLVEKLLKKQENRGQVDTKAGLLGDERFAQLFEDEEFMVDENSREFQLRNPSTVVSQDADPKAPTRYQAKDSEDESSDDERESTSTGRPKDELVMQVSSSRDDDNKVKTRDTALGSRQQRSDRGSRAQQSDVVGERQVTFIPQLKRKTHDAPTPRKVLSGRRSASSNTFRRMGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRK0</accession>
    <name>A0A367LRK0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_1824</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRK0"/>
    <dbReference type="STRING" id="1330021.A0A367LRK0"/>
    <dbReference type="OrthoDB" id="4927622at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016811649" description="CFEM domain-containing protein" evidence="10">
        <location>
            <begin position="18"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="11">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="9">
        <location>
            <begin position="44"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI17041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="150" mass="14833" checksum="7C66ABD25E5C6DF1" modified="2018-11-07" version="1">MQFTAAVILAVAAVASAAKGPGIKDLPNCAQHCVADAVKGHTDCGEDALECICEKADTLAVQSADCVVESCGTGYQVLPKGLQVCIAHAKHKNSARQIECVPVQVATQTSAQVVTTTVGPRPTSSVVTAGAAAVGPAGGIAALAVAAALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRQ6</accession>
    <name>A0A367LRQ6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="17">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">L249_2107</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 17">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PPP phosphatase family. PP-2B subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="17"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRQ6"/>
    <dbReference type="STRING" id="1330021.A0A367LRQ6"/>
    <dbReference type="OrthoDB" id="5593063at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033192">
        <property type="term" value="F:calmodulin-dependent protein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050085">
        <property type="term" value="F:mannitol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097720">
        <property type="term" value="P:calcineurin-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019594">
        <property type="term" value="P:mannitol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05352">
        <property type="entry name" value="MDH-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07416">
        <property type="entry name" value="MPP_PP2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000090">
        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041751">
        <property type="entry name" value="MPP_PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043360">
        <property type="entry name" value="PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45673">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="7 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="19">
        <location>
            <begin position="630"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="859"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="957"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="865"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="957"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="980"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="997"/>
            <end position="1006"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00053858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RCI17135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1006" mass="112509" checksum="5A48AC2406203D05" modified="2018-11-07" version="1">MANMLGGRDDAGIANGDRVLPLFSLKGRTAIVSGAGAGIGLGVAQALAEAGANVAIWYNSNKQAVAEADKMEQEFGIKCKAYQVNVVSPEDVTRAVDDIVAEFNGRLDIFVANSGIAWPNQAFLDGTAETARKVMAVNVDGVMWCAKSAGIHFRRQQKEGKTLDGRPLENYVMGSFIATASISGTIVNLPQKQAVYNASKAAVVQFCKSLAVEWTGFARVNTVSPGYISTELIDFASPEMREQWRSRIVMGEWPDGDRREGRVKELKGAYLYLASDAASYTTGVDLIIDGGYSLPRGDQYPQDGGRKEDRWRGGPRREEHQPRSHYSLTRARKKYRRATSLPTQVFAYIKVPTASRQPPAAAAAAAAICTGGPSVGPKGKANLLLRHYLASCLSRLILALKHVSPYSSRYSSRYPSSRLPPFYHPHAPFSPSLTAFRGALRRAMEKDGGENMASAETRRNIQVDNAIRAIQEKKPVPDIDFTIHAMEDGTQVSTLERVCKDVQAPAMSKPTDEQFYQDASKTKPDINFLKQHFYREGRLTEEQALWILQQGTELLRAEPNLLEMDAPITVCGDVHGQYYDLMKLFEVGGDPAETRYLFLGDYVDRGYFSIECVLYLWSLKIHYPKTLWLLRGNHECRHLTDYFTFKLECKHKYSEVVYDACMESFCSLPLAAVMNKQFLCIHGGLSPELHTLDDLRNIDRFREPPTQGLMCDILWADPLEDFGQEKTSEYFLHNNVRGCSWFFSYPAACAFLEKNSLLSIIRAHEAQDAGYRMYRKTRTTGFPSVMTIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKITDMLIAILSTCSEEELKEETPSTSPHSPMSTGGGDDPNSIEFKRRAIKNKILAIGRMSRVFQVLREESEKVTELKTVSGGRLPAGTLMLGAEGIKKAISSFEDARKVDLQNERLPPSHEEVAKHQEEELATALQKAAHEADNDKKLQQLGRRLSVDRKNRPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LSI6</accession>
    <name>A0A367LSI6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_2403</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LSI6"/>
    <dbReference type="OrthoDB" id="5596576at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059065">
        <property type="entry name" value="Ig_Tag1-like_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059066">
        <property type="entry name" value="Ig_Tag1-like_5th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046368">
        <property type="entry name" value="Tag1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055011">
        <property type="entry name" value="Tag1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895:SF3">
        <property type="entry name" value="PRE-RRNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26174">
        <property type="entry name" value="LEA-2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26150">
        <property type="entry name" value="LEA-2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26153">
        <property type="entry name" value="LEA-2L_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22786">
        <property type="entry name" value="Tag1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Tag1 C-terminal" evidence="3">
        <location>
            <begin position="449"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="Tag1-like fourth Ig-like" evidence="4">
        <location>
            <begin position="572"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="Tag1-like fifth Ig-like" evidence="5">
        <location>
            <begin position="713"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF26150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF26153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI17369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="841" mass="90056" checksum="65FA0C4CB75ADDA9" modified="2018-11-07" version="1">MPEPEPTPSVTRADETETPHEDDDDANAPDESTPLLSHDGADPPTKKSCSGSKSRWRWPSIIAIVVLAVLILAVIGLGFVTPPAVREYVEKAAVLEPTSLSIESLTSDGVRARIQADFRLDASRVSDDGARRIGRLVTGAVKKLEAESSRVTLNLPQFDNALLGTAVVPALSINLSEGYNNRLDFVTDVIPGDADVVRRVANQWLDGKLEQLKITGATALRLNSGILPLGTHDVAESMVLQAKDIPSMPEYNISNLVVYEAPVGSDGKMGVAANVSLSLYNEYLISLDVPPLGLEVLVPNCNASESNIKVASVVADTIHVRPESDVEVDAHGSISKIPESLTRTCPDTKLSPLDSLVGRFLHGEKAQVFVHGKVPADSDLPDWAGSMLESFVVPLHLGGQSFDSLLRNFSFSDVHFKLPSPFADPDDASSKPRVSGTVQVLAALPAKLDVDVGIDSIRADGDLFYGGRKFGQLRLNKWQKANSTTDYEDGQQTITIVSQVVDAPVDIIDGPVFGEIMQKLLFGDGDIVLDVKAAVDIRVATVLGKLALRKIPAEGKIPIKHVPGDDIIGAMKPEIGDIKILDTTETSVRLQASANLTNATPYTADIAYLSVHIMKQGHWVGEATVRNVALRAGHNSGLSGSAEWNPTTFGGSAAKEVGRRLMSDYLSGKETSIELKAHRGTIPSAPALGEALSTLNLTLRAPRLQLPGDDGEEVKTGFLRQATLHLISSTATFTLASPLQHDSVRVKHIDATALYNHTEPVGRIVHDEAFDVRPGLSQTPRLPVDWTPGHVGLDKLKKALGGALKLDAVANVTLGLGLWTERIEYRGRGIGARVGLFTEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZ10</accession>
    <name>A0A367KZ10_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_4502</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000030">
        <property type="protein sequence ID" value="RCI07411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZ10"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI07411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="75" mass="8554" checksum="0DC798F158E3F736" modified="2018-11-07" version="1">MDKNRYVLAIKTTTGNKIRKIRYSLDDIPDQKYDENLLSLREDILVDEVVTLLNSILSSSFSGYGSSGNVIYDYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZ15</accession>
    <name>A0A367KZ15_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000030">
        <property type="protein sequence ID" value="RCI07406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZ15"/>
    <dbReference type="OrthoDB" id="10547533at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI07406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="145" mass="14897" checksum="8D8616DC7E650A89" modified="2018-11-07" version="1" fragment="single">HLSVRQPTVAHLSPINKPATDQSTSRASQSAANSRPAASKPSVQSAAAALHKISTKDPIPPAAIQSSRHLSVRQPTVAHLSPINKPATDQSTSRASQSAANSRPAASKPSVQSAAAALHKISTKDPIPPASHRGSSILSSGFNLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZK4</accession>
    <name>A0A367KZK4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RCC1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_1640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000026">
        <property type="protein sequence ID" value="RCI07594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZK4"/>
    <dbReference type="STRING" id="1330021.A0A367KZK4"/>
    <dbReference type="OrthoDB" id="60092at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF466">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="2"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="RCC1-like" evidence="3">
        <location>
            <begin position="4"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="266"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI07594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="362" mass="37870" checksum="6D54F84E0E8BAD90" modified="2018-11-07" version="1">MNAIFSIGSNSSGQLGIGHHEDVSVPKQVQFNPSPPSEPIVQVAAGGNHTLLLTKSGKLYWSGDFTSGACGLATRPTVPLFQAVRLVEEGKPQPGPVYAVAATWEASLIAARDADGRVTRLFALGTGMKGELGAGELVVRTPTATVIGGFPPADTEVVCVAACMGHAVVVISNGDAYGWGNCRKTQIGHPAAVLHSPRRILDIGFPVVRAVCAKEATCFFGGPESGHIRVMGSDKWQLCSQAPTTAPSWADVGAGWGNFYILCKDGSLLGWGRDDHGQLPPPGLPLIMKMAIGSEHVVAVSEQGDALSWGWGEHGNCGPQVERGNVKGRWNVIASARFMPSGHRIYGVGAGCATSWICINGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZQ9</accession>
    <name>A0A367KZQ9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5907</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000025">
        <property type="protein sequence ID" value="RCI07660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZQ9"/>
    <dbReference type="STRING" id="1330021.A0A367KZQ9"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI07660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="97" mass="11067" checksum="C4BA2CB292607562" modified="2018-11-07" version="1" fragment="single">KIRTDKATFRDKEDRIGFLFRSLEGKACKTLKTYLLTKTKDNSLSYKDFCGYVKDSAVKRLDTELVLPNDLPALAKYSLSILLPKTPLLNRQIDLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZS3</accession>
    <name>A0A367KZS3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Heat-labile enterotoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_5677</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000024">
        <property type="protein sequence ID" value="RCI07693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZS3"/>
    <dbReference type="STRING" id="1330021.A0A367KZS3"/>
    <dbReference type="OrthoDB" id="4936804at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054208">
        <property type="entry name" value="DUF6914"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21858">
        <property type="entry name" value="DUF6914"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016768392" description="Heat-labile enterotoxin" evidence="2">
        <location>
            <begin position="25"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI07693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="657" mass="74663" checksum="A27450B161D873EA" modified="2018-11-07" version="1">MITLSLLLHALVWLLHSNAIVAHAVEVRISPTHVDVDSQSSSLFTKRQVENEIILAVYFRSIYLDTALRRAQGSNAFHWSLHVTPKGGSGKTTNAFHAVNGEEQRNPDPKRFKYLSEMIDPVKQPTLLGRIKLGTKPSEVTVDDMDKMLSQIRVPNRLENPSENCVSWALDGIRKLQENGVIEKFDTGSEFEKKVTQYGEDRYMDIFKPDIEDANLGIGRLDIRTGNIVPPPVNNKGPKDTSTEEEEEEKEKEKEKEKEKEKTEDGPQTENELCRRNIDNCAPQEDVNREELQPLTEEELINHYERFTSQEFNRMVTQAGHEYLLQRSKNPVSYQEVHKSVQVQKPRLAAEVKGRVAEIGGGALAAAGALVWIKNMIDVFSTNSTKWEQAEVVTSILPFVGCAVQAEGNHEEGKDNVADSAMCFASDALLLTPAWPVGVALQLVRLVMGWASEGDQEYNRLRQPKVLHELFIKGWEEHRAKMIKGIVSSDNFKKNLESQFISEQLAILYSASHTAGGLHAASLQEAPTMEKRKLREKSKEYHGRYELKQSVCDELSKRKSRLADDVEKEMVKLMGEKRHEFEKNFFSKAEQYLVDNVRRAVWMPMANYGKSTDTKRTIGMYVTRTRRTYPKGPVLSDENIKDIRKQVEDLDSPDFCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0V2</accession>
    <name>A0A367L0V2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_7863</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000022">
        <property type="protein sequence ID" value="RCI08060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0V2"/>
    <dbReference type="STRING" id="1330021.A0A367L0V2"/>
    <dbReference type="OrthoDB" id="4161332at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF85">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="72"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI08060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="669" mass="74811" checksum="9E3F49EF73A0DF4C" modified="2018-11-07" version="1">MSSVKTKKKSAFSCDPCRRRKVKCGGEQPVCQRCAARNDQCIYKLNPTLSYTQRLEERIKELEDQLADLARVPASNSSQPSPPPAKSHDSPSPGMARSFRGLKVDDKGSITYHGTTSFFNLPSDRFPASDILAPAETDLRRRERLVNNAWQQRALENMSEIPEPFQYLLHVHWCWIQPMFNFIYRPAFTRDMQSLGPYYSHTLLNAVISHSIRWGQSDPSTKRLLDQSYDGGAVFAQHTRSMVFDELSRGVCTIPTVQTLLLLSAQECSFGNSTQAWTYSGLAFRLIDHLGICVDGRRFPGSVPLTDEELEIRHRVFWSCYFWDKLISLYLGRSPSLQQSSMSPPQIMFDDSAEEDIWVPFGAQQVGVTWKYPPTTAHSASCFMSMCRLSVIFNEMLVHMYDPLSQNTDAEVQECLRTQEPALQEWWNQLPTHLRLDPAVLPALAPPSHIVTLNCLYHTFKILLYRPMLTGRGKRNNDGDGTSPAKSHLFECVTSATAIITIFDLFCRTFTMNYCVLSLAYSVYTAASVFLLQVQASPGEQQATRRLGYCCQCLSQVKTISPVIKSALDLIHSALDGTVIDAASPCPSQPAESKGDASTSSMPMYQNSVEMSRQMPLPSHPLFQPAANHILGTESMAMHPDVIETMSNLEPLSVRVGAMAGPENQVSTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1C9</accession>
    <name>A0A367L1C9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1C9"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="96" mass="10365" checksum="955D6A0E40C81A99" modified="2018-11-07" version="1" fragment="single">HSAYSGVGSIRSIGLTRTSLPPNHRSSKYVRVLQVGTLKYLEKIISISFSHLLNTNTSPASNSSSIASFRPSRDSSSSSLSRDHLPDSSTLHPLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1F0</accession>
    <name>A0A367L1F0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000022">
        <property type="protein sequence ID" value="RCI08042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1F0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="124" mass="13962" checksum="A60E40A5CB481119" modified="2018-11-07" version="1" fragment="single">MCLWTMIKCMYAVLEDAPSACFRRYPHGNSSSPVVFFLLTITSRRRSGPPRKEREKGASRPLTTFINHLLHNAHHSTFNLSFLGKVLMIHLFSSKTTPVFPPSSKKLATSRNGHFPPSLPLPIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1N1</accession>
    <name>A0A367L1N1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">U2 small nuclear ribonucleoprotein A'</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">L249_8974</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the U2 small nuclear ribonucleoprotein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367L1N1"/>
    <dbReference type="OrthoDB" id="242910at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071561">
        <property type="term" value="C:nucleus-vacuole junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13980">
        <property type="entry name" value="STKc_Vps15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000497">
        <property type="entry name" value="Phosphoinositide 3-kinase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000652">
        <property type="entry name" value="Related to VPS15-ser/thr protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000026">
        <property type="entry name" value="U2 small nuclear ribonucleoprotein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055231">
        <property type="entry name" value="2AA_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045162">
        <property type="entry name" value="Vps15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583:SF0">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22956">
        <property type="entry name" value="VPS15-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 14" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="25"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="1131"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="1437"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="942"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1015"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1483"/>
            <end position="1507"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="1754"/>
            <end position="1781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1025"/>
            <end position="1036"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RCI08331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1799" mass="199831" checksum="8BAFA7013D6554E4" modified="2018-11-07" version="1">MGQGFSLATPSAGSATIDVAQLQDVQYERSLGNGRFMKSIRGRHDNGVVLVKVLVKPFPDVNLDEYKRQIISECNRLGPMILPHADGVVTLMAYPEQRKALAHVPNALAFQRIIETETNGYLVRQYQYSSLYDRLSTRPFLEEIEKKWLAFQLLCALRDCHARDVYHGDIKAQNVLVTSWNWLYLTDFSSSFKPVLLPDDNPGDFSYFFDTSGRRTCYIAPERFYVVGKNPPPKAEMTWAMDVFSAGCVIAQMFLESEIFSLAQLFKYRLGEYDPVATHLSVISDRDVRDMIAHMIQVDPEKRYSADQYLQFWKGKVFPPYFYSFLHQYMELITDPSSGINPMSGSQKNMGESDDRIDRVFSDFDKISYFLGYQVEKRALAAEMPPPRLGLGHFPVRLSLASHNMPVSADLEPPEDDGTLIFLTLIVSSLRTTARASSRVRACDILLAFAERLTDEAKLDRVLPYLMTLLRRDEAEIVVVSAIRTITQLLQLVRMPTPINSHVLVEYVLPRMELALGSRSRAASPLVRATYASCIGSLASTGQRFLEIASSLRADSSMPIADPEVEPGLEAEVNFESVFDSAGRELFEMLESHTKQLVEDPDVHVRRAFLTSVPELCMFFQEHSNEILLTHLNTYFNDRDWTLKSAFFDAVVGITTFIGSTSLEEFMLPLIIQALADPEEFVVRAALHSLAQVAGLGLLSRPKLWELTDVSGRLTMHPNIWIREAAAEFLAMSAKFLDPADVRCILIPLLKPYLKVAGLVDVSELGILDCLRKPLSRAVFDQAVAWASQADRGVFWQPLRRARSSSLGHSNGLSAGSSQDLGANLLAKAARSDEDKQWLEKLRNLGLQVEDEHKLVALREYIWRTARAKGRDAEAVTPNGLVSLKALGVTPQTVFFNDAPLKDSSIVPDLNSPPGPYTIAEALLDASMTLGDSVARRRQAAALNGHGSRVHSVGPRMPRAPRRALSPGGSERGGSVRPRGESPINRGGGVGDEEPLLRDGLYSIRRGVRQQASALSLLDRKDGSNKSTAETGTSDANAFGEVEGPFIQASPVSAGDVDEGRTSSRQSRHSYEGTDPNIQRMLDRMYIDNFPRDVLEFGPMVTPISGGKHRIVNSQPGSYQWRPEGHLVAMFAEHKGAVNRVAASPDYVFFITGGSDGSVRVWDTARLERNITHRSRQTHRHAEGARVLALCFVEKTHCFVSCASDGSVHVVKVDTVSASGVVRYGKLRVVREYQLPEGEVAVWCEHFRQESASTLILATNRSRLLGMDLRTMTVLYELENPVHHGTPTCLCVDRRRHWLCVGTSHGVIDLWDLRFKMRLKAWGVPGKAAIHRMCIHPTKGRGKWVCVTGGTGQGEVTVWDLEKTTCREIYRAGGSGGKDNAKAYVPWDVDEDKPEGMLARFATNLESDDTASADRGVHAMVVGTGTAEDSRDVRHAYIATGGSDKKLRFWDVSRIESSCVYSGLQPEEAVPTYGATHPTTGLTLNTERASGPGAGGGARSKGSRPPRSTVISMQQQQLLQSHLDSVLDLVILEYPYTMSVSVDRSGAVFVFQYLGRSTTAVAMRLTADLIQNSLSYLNPLKERELDLRGQRIPTIENLAAAGPHDAIDFTDNDIQVLGNFPLSPRMTTLLVARNRVASIQSDLARSLPNLTNLVLANNNLAELADLDALSGFPRLTHLVLIDNPHYRYWVLWQCQDLRFLDYAKVKQAERKRSLELFGTAAEPSKLATEILARKTTPLEMSAKGSSRSSTLSRMMLTEEEKKRLQEKIKQTTSLKEIIELERELNEGRLPSGIQDAMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2F7</accession>
    <name>A0A367L2F7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protection of telomeres protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_4887</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the telombin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2F7"/>
    <dbReference type="STRING" id="1330021.A0A367L2F7"/>
    <dbReference type="OrthoDB" id="2186770at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000783">
        <property type="term" value="C:nuclear telomere cap complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098505">
        <property type="term" value="F:G-rich strand telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010521">
        <property type="term" value="F:telomerase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032210">
        <property type="term" value="P:regulation of telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016233">
        <property type="term" value="P:telomere capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028389">
        <property type="entry name" value="POT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032042">
        <property type="entry name" value="POT1PC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011564">
        <property type="entry name" value="Telomer_end-bd_POT1/Cdc13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14513">
        <property type="entry name" value="PROTECTION OF TELOMERES 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14513:SF0">
        <property type="entry name" value="PROTECTION OF TELOMERES PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02765">
        <property type="entry name" value="POT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16686">
        <property type="entry name" value="POT1PC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="Telomeric single stranded DNA binding POT1/Cdc13" evidence="10">
        <location>
            <begin position="21"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Protection of telomeres protein 1 ssDNA-binding" evidence="11">
        <location>
            <begin position="179"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="336"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="445"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="445"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="470"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI08604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="624" mass="70891" checksum="E737884CE2B19478" modified="2018-11-07" version="1">MSLPSRYVSGRDILDGKRIKGTKANVVGLLLDVRDPIPTKGSDWKCEYRLYDKSLEDGVDSLALTIFRPKDKMPADANLGDVIAVFGAKVQCRYGDMSLISNHTTVLHIYDHSKIPEPPLDALIALQPSIMRATRAPTPEEALFVSVLYKTINRNRLPSRADFEAQKAQSVNIKNKFSELKNVREGVYVDVLVQIVKAPYDEYDKCSVWVSDYTENDLFYNIAFSGQESGETRPYGKRSMQITCFEPHASFLRNEQLPVGSWIYVRNLHIRLGRNGSNLEGTLHGDEKNLAKVNIEPVVVNQESASNNPQLKAALRRKLYYGKDKKAQLREIDEAVESGQKRKAQTEQSTVQKPNRQRRRKIEREKKLKETEQEDVLDALPNLNKQVKCENTNKAVSSLSQIMQPVFYETTIDDQLVKLRLPFVNANYRTVVRVINFEPSQLERFARPRPRSDTDMLPDMDQVSDSSNSEQDEEEEEDANTVWEWHFALELEEVINDDAQKPPKTMWVLVDNHAGQCLLNMDAADLSRDSQLLQDVRQRLSILWGERGDAKVRAQPARFLQYCNAPPSSDTSPVLEQASPLPFSCCLRQYAVTVAEPDAQKADAGDGTRWRRVFGLFGTRIVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2L2</accession>
    <name>A0A367L2L2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_4641</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2L2"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016861083" evidence="2">
        <location>
            <begin position="48"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI08655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="234" mass="25822" checksum="0FBC0E8947EF6EBC" modified="2018-11-07" version="1">MSPSADVLGVSDLMPTRRGYNRHPRHFSYILLLSAVVLLLWTDHGDAKGGKSSTSSISSGGFGTSGPSRSSGGLKRFNSNSKAAQKPQTNTRPNTRPGSSGGVPASGGRSPSPAPGTSGTQQPVTSLSDREFMAGERMLLSDYRHQKEINALGWLKKTQPQQFRQLVQDHVDKIKGLTRYVDPAVREKNRLRMKDHIDKQKEKLRTADPVAYDHIQTLSLMGHRARREPPRITW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3E2</accession>
    <name>A0A367L3E2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycoside hydrolase family 5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_5071</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI08951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3E2"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF143">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-SPECIFIC PHOSPHOLIPASE C X DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016825809" description="Glycoside hydrolase family 5 domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="521"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI08951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="584" mass="67373" checksum="C0EB0256CD071905" modified="2018-11-07" version="1">MKPLSTVLLLAATSFIPQLLAAPLDNDKKRGLGRVNVEWDLFDDPKSGIQLHDEPEMVITLINATPYRWRKGYSHSYKAPRWEFWPDVIHQGDSKSAYVSSKHFSRDSAAEVVYHLEGTHKPMSIRVEWRSGKYHDTYVVFQDELETMNNAKETAHFLGAGWWPNGVGFMLAGTEENFISNDGPLNWMQSLLPHIGNFSLRELAMPRSHHAGMWKFVAPIGVGSFGNTGTQLDDLWNQLGNGGVRVLDMRPTLWNYHFRESHHSTAGLLGEQGAYGAGIEEMIDIINRFNSEVPGELIIVDLHPDLSDADRWADLSPFQLDQLYNLMRKLEHRFAVPDDDDDDLTSWPLNRFIGDGQSAVLIRLSSRWLDRFDDKGQGIFPGGKEGFVTDKNFHTNGHWSNTNRISVLAEDQFTELRDSRPHRDSPMLDFSWVLSQDSLQVIFGPSILELSQLTWRTLYTVFWNFITENTYPNWISMDNSHGSQLKAMVMTINYCLVARQCGGVGGKVDMWWVEQRRLEAEKKQKEEEEQRKKEEEDDERKQKQKQKQKQKQKQKQNDNDNDNDNDNDNEEQKKEGEYNDKEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-05-03" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3L8</accession>
    <name>A0A367L3L8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI09019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3L8"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016670093" evidence="1">
        <location>
            <begin position="20"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="103" mass="10623" checksum="DF080494908BA44F" modified="2018-11-07" version="1">MVLLGLLPLLLLLLPLKDAHTEADCIAEEGTPCLTCSEEAVAVAVAVAASYVVVLFLPLRAVAVAASYVVVPFLPLLCDVRRPRAGYGRPGVTVSGAPAKVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L415</accession>
    <name>A0A367L415_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HhH-GPD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_1529</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alkylbase DNA glycosidase AlkA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L415"/>
    <dbReference type="STRING" id="1330021.A0A367L415"/>
    <dbReference type="OrthoDB" id="415889at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032131">
        <property type="term" value="F:alkylated DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043916">
        <property type="term" value="F:DNA-7-methylguanine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000004">
        <property type="entry name" value="DNA-3-methyladenine glycosylase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051912">
        <property type="entry name" value="Alkylbase_DNA_Glycosylase/TA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003:SF5">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="5">
        <location>
            <begin position="182"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="17"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="64"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="103"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI09175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="368" mass="40829" checksum="527C23E4D4FA130D" modified="2018-11-07" version="1">MSELSLFRSIASLRNPFLHQRASFGPMSVPRRSSRISAQLKAPPPHPGPPAKKRKREATPEAVAEERIDPVTPDTRKPGALPRETVARLADPTATNATLVSPETSRLVTSRRVRSESPSSSTTRAQRKTTTTDNLLQEACKHLIKVDERLRPLIEKNPCHIFSPQGLAEKVDPFESLASGIISQQVSGAAARSIKAKFVSLFDLGGDGVESRKRFPPPSEVAACRLERLRTAGLSQRKAEYIQGLAGKFVDGELSAQMLREAPYEELVERLVAVRGLGRWSVEMFACFGLKRMDVFSVGDLGVQRGMAAFVGRDVAKLKKAKGGGNKWKYMSERDMLELSARFAPYRSLFMWLMWRVEDSFTDVSSME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L426</accession>
    <name>A0A367L426_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5055</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI08962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L426"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="104" mass="11450" checksum="92918F2971B7B6E0" modified="2018-11-07" version="1" fragment="single">MQQRQRKKKKSISNIQSMQENTILASTIPSTSQTTRPHTGLPPNGCGRCPGDGYVLYLSSPPNILPTSWDLRTGRNLRRGRGGVTPARLLATLLSTYLGRSPHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4B6</accession>
    <name>A0A367L4B6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_1499</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4B6"/>
    <dbReference type="STRING" id="1330021.A0A367L4B6"/>
    <dbReference type="OrthoDB" id="1854502at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097038">
        <property type="term" value="C:perinuclear endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035621">
        <property type="term" value="P:ER to Golgi ceramide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120009">
        <property type="term" value="P:intermembrane lipid transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030011">
        <property type="term" value="P:maintenance of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13289">
        <property type="entry name" value="PH_Osh3p_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000369">
        <property type="entry name" value="Oxysterol binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000001">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041680">
        <property type="entry name" value="PH_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF203">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15409">
        <property type="entry name" value="PH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PH" evidence="7">
        <location>
            <begin position="203"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="297"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="362"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="406"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="464"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="507"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="902"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="178"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="370"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="406"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="510"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI09275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="988" mass="107843" checksum="9DF78128F7F4723F" modified="2018-11-07" version="1">MAEIQRLEVHSKARSYVVRWLKVDQGHTLSWSVQPHKKSINVGIVKHPAGAAPPLSSTTDDVDAAQTQAFARSTKKEPTAQDMLAAKGFIPILWHGKCEADKTSPGTYDVQPGQGGMYGLVFDNTFSKQTSKTVTFVVINYPTGSPPQTAGQASNLSMPRDPSSHSSLARIASPRNDFMSSGSADSLHSQGARGPLSARSDLQTCNVGYLSKRRRKKGQGYARRFFSLDFSTCTLSYYYNRNSTALRGAIPLSLAAISADERRREISIDSGAEVWHMRAYSDREFQDWARALERASRIARSNSDTPQPPSDSRSDLTRQAQQPVASEDIEWQQVETLVSRVVGTRDALRRLTTEAAALPRRSVSGQHLFPSDDARDGDSPTSGDKRPFWKRMSSMPMVNPLTLQQVASSPDQTPTPWTRESMGASRPGLRAGAKDDSRSIHHHCEALLADLNSVVSEFSTLLNNKRRRRMAATSSSLAGGGASRVSIDSVSTKDEFFDAEDAKPAVVKIGSGGHGGGGGSGSGDESPNPEGDGDADTRDDGSSVMSTEDAETASGEGQHLFPTRPKSLAPLPMDTTVARRTTIPAATVQPPSLIAFVRKNVGKDLSTISMPVSANEPVSLLQKLAEQLEYAQLLNQAAQRANVTERLLLVSAFAVSQFSSGRAKERSMRKPFNPLLGETFELVRTDKEVPGGFRLLVEKVEHRPVRLAMQAESANWSFSQSPAPGQKFWGKSAEITTEGRVRVALRLVDGSDELYSWNVATMFLRNVVMGEKYVEPVGNMTLTNESSGHKAVVEFKSKGMFGGRSEEVQATAYGPDGADTGRGLVGTWTNGLRMVGPGKTTTTTTTTTTTTTTTEVWRVGRLVEQAATTYGLTEFAASLNELTGVERGRVAPTDTRLRPDQRLAEHGRLEEAEESKQRLEEAQRVRRRDLESRGETYRPRWFYRAEGGPEGEEVWKLKTGKEGYWEERERGEWTGVGVGGKIFDEGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4M9</accession>
    <name>A0A367L4M9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_3702</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000015">
        <property type="protein sequence ID" value="RCI09379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4M9"/>
    <dbReference type="STRING" id="1330021.A0A367L4M9"/>
    <dbReference type="OrthoDB" id="5397682at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33604">
        <property type="entry name" value="OSJNBA0004B13.7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33604:SF3">
        <property type="entry name" value="OSJNBA0004B13.7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="558"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI09379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="672" mass="74975" checksum="EED97D757B7C3FD0" modified="2018-11-07" version="1">MARQSAWTMSKLWRDDEEMAKKDDDHNTRRPTAPPWSAAVRAPRPSWLLRVVIYLFAACVIVFVIYNAAGLGYRHENDDDDSFTPLSSRSRDLPQVRIRPRPPGLESGFDDAAASQRQVKDGPIQHRELLVSIRALATAGNGLSRNRNILFIAAELQSATTLLPMACSMARELHSHVHFAFMGRSDISMQQLLKINGIDGSCPLLIHDARPDYAATSTEDRMTLAVERALIIFQRLVPPQVLLVDSTTAEESYLHQGTRAYAEKFQTTVIELPKNPGTRLSWITKLDSTALAAWNKVRFDIIVHSPRTGTGNLKRLLQSLARADLGGHHVPHLVVELPSVVEPSLQEFLGGFQWPPPRSGAAPAPSMLSLRHRILRPRLSEEESSVRLLESFWPLDPSLSHVLYLSPHVEIGPYFFHYVKYCLLFRRHSRVASRESLTSNVMAMSFTLPSTTPNGEQPFTPPRSDDEAATAFLWQAPTSDAVLFLGDKWVELHGYVSRVLEAQQTMTDPPPILANKQIGRQSPAWLEYALQLSRLRGYVTLYPSQETAKVIATAHSDLSHKPEEFGPSTAAEDRRRQGADGQLVEMASSQVDMLGALPDEGLQKPLEELPLLSWDGRLLDGAEALDKDATEVAMTFRRQVGHCSEADLEKDISADRHGRDLFCISQLGYSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4X4</accession>
    <name>A0A367L4X4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Stress response RCI peptide</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_3963</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4X4"/>
    <dbReference type="STRING" id="1330021.A0A367L4X4"/>
    <dbReference type="OrthoDB" id="2802411at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF57">
        <property type="entry name" value="PLASMA MEMBRANE PROTEOLIPID 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="77"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="139"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI09493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="148" mass="15968" checksum="E61F59CD914D281F" modified="2018-11-07" version="1">MCSSDIFLGFLAILFPPLPVWVKCGICSADSIINILLCVLGFFPGLLHAWYIIAKFPDRSCDGMAHEHEAGRVTYVYVQPPDNGRQPRPHGNMNYGTQSAAQPQQKPSSREEHGVAAAGSSSNDNGPHGVPPSYAEVVAGDHKVQSHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L507</accession>
    <name>A0A367L507_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_4082</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L507"/>
    <dbReference type="STRING" id="1330021.A0A367L507"/>
    <dbReference type="OrthoDB" id="271862at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00105">
        <property type="entry name" value="KH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22453">
        <property type="entry name" value="KH-I_MUG60_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056553">
        <property type="entry name" value="KH_Mug60-KHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627:SF76">
        <property type="entry name" value="KH DOMAIN-CONTAINING PROTEIN YLL032C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627">
        <property type="entry name" value="SCP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24563">
        <property type="entry name" value="KH_Mug60-KHD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="257"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="486"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="556"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="661"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="922"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="978"/>
            <end position="989"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI09504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="997" mass="110501" checksum="96D52AB7DEAB36BB" modified="2018-11-07" version="1">MNKLANMRHWSERMSPNFSMGRPNMPINPLNPHPKNASQAGGPVTAPQIADNTIHFSFNVPFSSDLAGPNTEDIVHATTDAVLRWTHPEDAPDDVQVHELPVHVQNLAHLRKLCDDLTNGPLPIEAHALTSPLKNGRGQHIINVCLSGSPEIVHKSRESILNEIPISMRCTTIDIDGSLVCDLGAGVLKKPVVETLDYISSFCGVDIFLLGPKLTPMVDGMTGASEMRMDQRWRVAIYGDILSSEHAKARVLIHIDTLLGRVVDVAKVELSLQQLVCGRHRKNIKLIESSTGTAIYFPPLFSQMYRYCPPNANRRDPSDIFITGDTPHAIELAKQKLHETAARIRLYVKDVTIPAAKIDSILLTRLDKVRKILEANGTYIIFPPLACQRTLMRVQGGEGLPVERTVRELMSLAGQFYGAAWYTQQTDQRQLLGTADVRAILGDICANSDADLSFEKTNFTVTGSDDAVKSALMVISNLRFVTQAPYQIRVKIELANEHKEFVSGKKNGKINKIMGQSNVQIIFDGFNEYNFNIDVMAASYDSMKQGLTLVEQEMPASISFHVPDQYHKRIIGIGGQHIQRIMKKHSVFVKFSNAMDRGERSVPETLGRPRVLTNRLSGGMSREDDDVKVDNVICRTPARNAQNLDAVKNEILEMVDRADSEYTTQIASVDRLYHRQLIARLPEIDELEQKYSCKINFPSTEEASDEVTVTGPQWQVPHCVDEFLGMVPDRHELVLARTPELVKFLESPQFASELVTKLRAQYEVEVTVHQIPEEVTQDGSPTVTLFWGFTRNNAGGLRDAIDLLQAQVAAGGVEVLIVKGSIPRPKSDSFEDSLQYFDSKVLQHAPTSVAADSPIKVAFGAEVARERSSILDRLRKPGSMTSISSFLDRRKNSSHSINSNFFKGSSNVSKSSLISIESTRSFNADRNPWNDSGVNLPDDDHPWAPRPLSKHMDGKLTMPLPGDVTPRHGARGSGDSGRPSTSHSMNSGYPGQVGPFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L541</accession>
    <name>A0A367L541_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Gamma interferon inducible lysosomal thiol reductase GILT</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_4102</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GILT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L541"/>
    <dbReference type="STRING" id="1330021.A0A367L541"/>
    <dbReference type="OrthoDB" id="958254at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016671">
        <property type="term" value="F:oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004911">
        <property type="entry name" value="Interferon-induced_GILT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234">
        <property type="entry name" value="GAMMA-INTERFERON INDUCIBLE LYSOSOMAL THIOL REDUCTASE GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13234:SF8">
        <property type="entry name" value="GAMMA-INTERFERON-INDUCIBLE LYSOSOMAL THIOL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03227">
        <property type="entry name" value="GILT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI09545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="362" mass="38949" checksum="E89F30D3303A4DDB" modified="2018-11-07" version="1">MDEKTAATAPFRHQQPKMPPRLRPVVRLLVLLVFVVLVALSSVLRRPPTWARSFGTQTLADKSKLVPLEAHIISKCPDTRDAMRELILPVMQQVADKVDFRLNYIGTPVGDDGIQCKHGPDECMGNIVELCARELYPDAKTNLGFIYCLTRQYREIPKQALVEDCALEHRVDVKALNECATRDDGAHGLELLRQSVKHTASANVTISCTIRLNDEIYCIRDGGKWIQCPNGPGVSDLVAAIEKLHGIHTGLFVAGHGLQGLDYGVESDSLSGGLGGAGVEGDVDDVDVQMVICWLVVEVELQLVGLERGVSGKGGGDEASAHVLQPGNVLLAKVAQGPHVAALDEGEQVQGLEGGAIPVEIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5G2</accession>
    <name>A0A367L5G2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SYO1-like TPR repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_3678</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclear import and ribosome assembly adapter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000015">
        <property type="protein sequence ID" value="RCI09462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5G2"/>
    <dbReference type="STRING" id="1330021.A0A367L5G2"/>
    <dbReference type="OrthoDB" id="288703at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052616">
        <property type="entry name" value="SYO1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057990">
        <property type="entry name" value="TPR_SYO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13347">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13347:SF1">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25567">
        <property type="entry name" value="TPR_SYO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SYO1-like TPR repeats" evidence="3">
        <location>
            <begin position="405"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="630"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="642"/>
            <end position="652"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00049983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI09462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="652" mass="71401" checksum="5B0B49621B321FE7" modified="2018-11-07" version="1">MPKSRRSRGGPRQLRDPLTRIVKPPSDPRLAALRQDKVLPVVEDLSSSDTKKRSAAAIAAASLAQDPECRRLLLREQIVHRLSNRSITDVALETRAAAWGIFQLLAKEQGDDFCLHLLRQDILTSMDDAARVTLHKLRSNFDSLPKAEKSFVISIAASLISLATTLAEACVDAMNAIVAAIAENDSIAKLLGLAVRHPSPIANLRADALAGLMMLSEDNQQFSKEFARCPHFRSVIALKDKEDAEGVLACALLHNIFVALDASTTGVRVMGVGDANLVPTLAKAISPPTSPDTVTGGGWSDPVKSQRLAIQVLASIGTAINNSPVEEPNPRYIGWLPRRAEDDDFDKPVSDADEVDMMNDLDRVTDSESNNGEDIVSVFKALVKTALPQLVRLSRLEPSGDNDADVRSLALSALSNIAWSASVIDLADRRNAAIRRVWVPGARFLWQQLISPLLATDMADLAFAAQVTGLAWALARVLSGKTPLKAGEHAKFMALYRASKDEPSPDSDPFQSLGTKCIGVLGHLARDPAPLEVNREIGLFLMSIISAAPKTPVTSAHLVEAFDQLFGIYANEQHACDRAVFWEENFFFQNPELGDRIAKTASSSIRFAAHKKKHAPLDWRLIRERAGQEAWRPSTSRKHLREKKESWLKPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5H9</accession>
    <name>A0A367L5H9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit G</fullName>
            <shortName evidence="5">eIF3g</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 RNA-binding subunit</fullName>
            <shortName evidence="5">eIF-3 RNA-binding subunit</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Translation initiation factor eIF3 p33 subunit homolog</fullName>
            <shortName evidence="5">eIF3 p33 homolog</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TIF35</name>
        <name evidence="9" type="ORF">L249_3785</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit G family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5H9"/>
    <dbReference type="STRING" id="1330021.A0A367L5H9"/>
    <dbReference type="OrthoDB" id="639027at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12933">
        <property type="entry name" value="eIF3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12408">
        <property type="entry name" value="RRM_eIF3G_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000328">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03006">
        <property type="entry name" value="eIF3g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017334">
        <property type="entry name" value="eIF3_g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024675">
        <property type="entry name" value="eIF3g_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034240">
        <property type="entry name" value="eIF3G_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12353">
        <property type="entry name" value="eIF3g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037949">
        <property type="entry name" value="Transl_init_eIF-3_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="216"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="180"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI09679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="296" mass="32460" checksum="F56A704C9C95A8BC" modified="2018-11-07" version="1">MAAVASSKPKHDWADDDDIEEMTTDLPPPQTISNKDGTKTVITFRYNDQGQKVKTTRRIRYVTHTETVNPRVADRKTWAKFGQSAKDGAGPAGDTTSVGENIIFRPSVNWRKDSKDESQDPNSQAMKDKLKDKKVKCRICNGEHFTARCPYKDTMAPMGENGGADVAAGMGDEPAVGAAGAGKKGSYVPPALRGDRSAAPGERMGGSKYGERDDLATLRVTNVSEMAEEGELREMFERYGRVTRVFLAKDRETGMAKGFAFISFADRSDAVKACSKMDGFGFKHLILRVEFAKKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5M8</accession>
    <name>A0A367L5M8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Iron-sulfur cluster biogenesis chaperone, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_4070</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for the assembly of iron-sulfur (Fe/S) clusters in mitochondria. Assisted by the DnaJ-like co-chaperone jac1 and the nucleotide exchange factor mge1, it mediates ATP-dependent Fe-S cluster transfer from the scaffold proteins isu1/isu2 to grx5.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5M8"/>
    <dbReference type="STRING" id="1330021.A0A367L5M8"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11733">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000014">
        <property type="entry name" value="Chaperone protein DnaK HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000020">
        <property type="entry name" value="Chaperone protein HscA homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000007">
        <property type="entry name" value="Heat shock protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000004">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000003">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003520">
        <property type="entry name" value="PRK05183.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="642"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="645"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="669"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00059314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00070638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI09735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="683" mass="74386" checksum="61D228CCEED817B8" modified="2018-11-07" version="1">MLASRLSRSLPRAARPAAFARAPLASRFVRRESTATSGDGKVQGAVIGIDLGTTNSAVAIMEGKTPRIIENSEGARTTPSVVAFAENDERLVGVAAKRQAVVNPENTLFATKRLIGRKFTDPEVQRDIKEVPYKIVQHSNGDAWVQARDQKYSPSQIGGFVLNKMKETAEAYLSKPIKNAVVTVPAYFNDAQRQSTKDAGQIAGLNVLRVVNEPTAAALAYGLEKSDDSVVAVYDLGGGTFDISILEIQSGVFEVKSTNGDTHLGGEDFDILLVRHIVSDFKKSSGIDLSQDRMAIQRIREAAEKAKIELSSSLQTDINLPFITADASGPKHINMKLSRSQLENMMEPLIKRTVEPVRKALKDAGLQAKDIKEVILVGGMTRMPKVTESVKAIFGREPAKSVNPDEAVAMGAAIQGAVLSGEVKDLLLLDVTPLSLGIETLGGVFTRLISRNTTIPAKKSQTFSTAADYQNAVDIKVYQGERELVRDNKLLGNFQLVGIPPAHRGIPQIEVTFDIDADSIVHVHAKDKSTNKDQSITIASGSGLSEEEIQQMVQDSEKHAEADKERKNAIEAANRADTVINDTERALKDYSSKLDPAEVKDIEEKIASFREFVVDFQSGKSNSTAADIKDKMDDLQRASLNLFDKMYKSQNENKNDQSPGGEGQQAPEEGEKKDESEKDKNKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5T0</accession>
    <name>A0A367L5T0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5T0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="49" mass="6056" checksum="01D49885640FFF6A" modified="2018-11-07" version="1">METSSSEQVKNHQRLNRRRTDTHIIIKHRSFESHHRLFRFFIVLHQTPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5Z2</accession>
    <name>A0A367L5Z2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial</fullName>
            <ecNumber evidence="5 18">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">L249_3840</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
        <text evidence="18">Binds 1 [2Fe-2S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[3Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:21137"/>
        </cofactor>
        <text evidence="18">Binds 1 [3Fe-4S] cluster.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="18">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 18">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 18">Mitochondrion inner membrane</location>
            <topology evidence="1 18">Peripheral membrane protein</topology>
            <orientation evidence="1 18">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="5 18"/>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5Z2"/>
    <dbReference type="STRING" id="1330021.A0A367L5Z2"/>
    <dbReference type="OrthoDB" id="1696654at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051538">
        <property type="term" value="F:3 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000007">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1060.10:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase iron-sulfur subunit SdhB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1060.10">
        <property type="entry name" value="Alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009051">
        <property type="entry name" value="Helical_ferredxn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050573">
        <property type="entry name" value="SDH/FRD_Iron-Sulfur"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004489">
        <property type="entry name" value="Succ_DH/fum_Rdtase_Fe-S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025192">
        <property type="entry name" value="Succ_DH/fum_Rdtase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00384">
        <property type="entry name" value="dhsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004616">
        <property type="entry name" value="PRK05950.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921:SF29">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] IRON-SULFUR SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11921">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE IRON-SULFUR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13085">
        <property type="entry name" value="Fer2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13534">
        <property type="entry name" value="Fer4_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46548">
        <property type="entry name" value="alpha-helical ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="16 18" id="KW-0003">3Fe-4S</keyword>
    <keyword evidence="8 18" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="14 18" id="KW-0408">Iron</keyword>
    <keyword evidence="15 18" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="18" id="KW-0472">Membrane</keyword>
    <keyword evidence="11 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="18" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="19">
        <location>
            <begin position="48"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="20">
        <location>
            <begin position="181"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00016766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU361237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RCI09841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="279" mass="31576" checksum="E07689637ED9FD75" modified="2018-11-07" version="1">MAALRSSSSRLLARTVLRPGAVTVTGRPLATVSDPPAQEKQQPRMKTFQVYRWNPDTPGDKPRMQSYSIDLNKTGPMVLDALVRIKNELDPTLTFRRSCREGICGSCAMNIDGQNTLACLCRIPAESSSEVKLYPLPHTYVVKDLVPDLTHFYKQYKSIKPYLQRETPAPDGKEYRQSKEDRRKLDGLYECILCACCSTSCPSYWWNAEEYLGPAILLQSYRWLADSRDERKEERKANLENSMSLYRCHTILNCTRACPKGLNPGKAISNVKKEMALGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6G4</accession>
    <name>A0A367L6G4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_8565</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6G4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI10020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="102" mass="11343" checksum="D76AB3ACB92623A3" modified="2018-11-07" version="1">MVVVVAVSRAGRVRAAMFRHGDAGGREQGKQRIASLHASRLCMPAYQVVSRDIGIQEMTNGHGVAGIMSHGIGSFVSQLHLCRRFWSVLDEMKCLAHHRYQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L710</accession>
    <name>A0A367L710_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial</fullName>
            <ecNumber evidence="5">1.1.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Isocitric dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">NAD(+)-specific ICDH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_8581</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:23632"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.41"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Octamer of two non-identical subunits IDH1 and IDH2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.41" evidence="5"/>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L710"/>
    <dbReference type="STRING" id="1330021.A0A367L710"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000001">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF42">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="13">
        <location>
            <begin position="39"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI10217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="373" mass="40505" checksum="D3BFA35D4A3A7D97" modified="2018-11-07" version="1">MLSRHPLRTTAQLLRGCTRSMATVQSDIFQPAKYGGKYTVTLIPGDGIGAEVAESVKTVFKADNVPIEWEQVAVSGLDEGGGRAEEAFRESVASLKRNKLGLKGILHTPISRSGHQSFNVAMRQELDMYASISLIKNIPGYTTRHRDVDLCIIRENTEGEYSGLEHQSVPGVVESLKIITRAKSERIAKFACAFALANGRSKVTCIHKANIMKLADGLFRNTFHAVAKEYPTLEVNDMIVDNASMQAVSRPQQFDVMVMPNLYGGILSNIGAALVGGPGIVPGCNMGRDIAVFEPGCRHVGLDIKGKDQANPTALILSGSMLLRHLGLDDHANRISRAIYAVIAEGKVRTRDMGGESTTHEFTKAILDKMEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7U4</accession>
    <name>A0A367L7U4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_4476</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7U4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI10489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="32" mass="3272" checksum="76C8967E621EEF20" modified="2018-11-07" version="1">MSASYKPSIASAVSEGDSFGIIEQGPNLGPNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7Y6</accession>
    <name>A0A367L7Y6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospholipase</fullName>
            <ecNumber evidence="5">3.1.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_4285</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1,2-diacyl-sn-glycero-3-phosphate + choline + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14445"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="3.1.4.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the phospholipase D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.4" evidence="5"/>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7Y6"/>
    <dbReference type="STRING" id="1330021.A0A367L7Y6"/>
    <dbReference type="OrthoDB" id="14911at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004630">
        <property type="term" value="F:phospholipase D activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009395">
        <property type="term" value="P:phospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09138">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09141">
        <property type="entry name" value="PLDc_vPLD1_2_yPLD_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.870.10:FF:000034">
        <property type="entry name" value="Phospholipase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016555">
        <property type="entry name" value="PLipase_D_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015679">
        <property type="entry name" value="PLipase_D_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896:SF128">
        <property type="entry name" value="PHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18896">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00614">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009376">
        <property type="entry name" value="Phospholipase_D_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="7">
        <location>
            <begin position="229"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="PLD phosphodiesterase" evidence="7">
        <location>
            <begin position="654"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="574"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR009376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI10536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="887" mass="101870" checksum="C0DD56A44C78B9FE" modified="2018-11-07" version="1">MSSSQDDQSGSFSSFVGDLRDKLHDSKLHDAKVHLIHKKHQIGKLGNPGERRPPLMSAALDVVVNRRTRQFNRDHRHDEEHEQRCDEKRTKTCETNRYQSFFPERDGNLVKWYVDGRDYFWAVSVALEEAQESIYIADWWLSPELFLRRPPYHSQKHRLDQILKRRAEAGVKIYIIVYKEVEAALTCNSRHTKNALQAMCPEGSPGYGNIRVVRHPDHNVFENAADMTMYWAHHEKFIVIDYYLAFIGGLDLCFGRWDARQHPLSDVHPEGVSEEIWPGQDFNNNRIMDFKKVEDWQQNELSKAEYGRMPWHDVAMALIGPCVYDIAEHFVLRWNFVKRDKHKRDERHDWLVLEGREGEDEDLVGVQRPKHPVGEYVKHPLTPLETKKLEGRGTVHAQIVRSSADWSSGILTDHSIQNAYCEVIRKAQHYVYIENQFFITATGDQQSPIHNTIGAAMVEAVVRAAKEGRKFRIIVIIPAIPGFAGDLRENAASGTRAIMDYQYKSICRGEHSIFERIKAEGVDPSQHIFFFNLRSYDRLNKTHAITEAEKKSGISYQQVQRAEAEEIMAEGVYGYEDDSSDDDRRPGNKSGAQRGPSENVIRARQVFEEAKPDEEVTSAASVAHHALLGTGSLKDEPWDDHEDPTSEIRNWIQEELYVHAKLLIADDRVVICGSSNINDRSQVGDHDSELSIVMEDTRMIPSTMDGQPFEAGYHAATLRRFLWREHMGLLPPQDLNAAGDINAEPPTVNPENNIYADDDSYKFVEDPMSDDLWSKWTGQADRNTLLFRHLFHADPDDNSKSLNSRVRLAGAHQDCTVKTFEDYDRYLPPKGVKSGHIYDQFMPPEDAREKLDQIEGHLVWMPMAFLKDAEMAERGLQVNAWTESVYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8J9</accession>
    <name>A0A367L8J9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5369</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8J9"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="85" mass="9453" checksum="AFEBECA209F956B8" modified="2018-11-07" version="1" fragment="single">VGKKGPNKVICIPSQRAEPGLITSKGYTSKKKKRNHVIKVRKADANDSSNTLTYLYTCTCRSDRSDRSDPMTPAMTAMTRPLRPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8L5</accession>
    <name>A0A367L8L5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_5365</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8L5"/>
    <dbReference type="STRING" id="1330021.A0A367L8L5"/>
    <dbReference type="OrthoDB" id="417481at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12532">
        <property type="entry name" value="RRM3_MEI2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034862">
        <property type="entry name" value="Fungal_Mei2-like_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007201">
        <property type="entry name" value="Mei2-like_Rrm_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23189">
        <property type="entry name" value="RNA RECOGNITION MOTIF-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04059">
        <property type="entry name" value="RRM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="442"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI10754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="638" mass="69847" checksum="B960AB905725852A" modified="2018-11-07" version="1">MAQNRDMENPSSPRSSSGGADSLKGTPDTRLTTFSPDNGSSKHPQGLPRSFPATSLDKDPFVTPSHRLGTRLSPTALAFSPFPAVKQLPFMGEGGPIAVALSDDLGLSRNVKVSSLMPISISEISLVLDGLEATGELPHGTRYFEAIDRHVLISFTDIRDACSALASIRVAGNSWEVEYAHPENKFPESIVSNSGKIFVFAAVPQGTTFGVSHAMDIARGFLQAHGQLFAFVGRSIFPNGSFRAVAEFCDVSTAVIAASNLGNIVTNEGIHFVFLPHTMTTTQPSDIVGTFQSLDLGQSHDESQAQRLSASSKITGTRPAHGLQIQSPFALYPLVVQPAPIGPAMSCMVNSFFPPASQGPATPLGPISPSFAGVGSLYHSPPSPALTVQKNYSLCRSIPGFGRSEARRQNALRISRSSNHSVAGHHNHVDINRIREGIDVRTTIMLRNIPNKVDQSMLKRIIDESSWGKYDFMYLRIDFANDCNVGYAFINFVDPLDIIDFVDARGNQRWNCFKSDKVAEISYATIQGKDCLVQKFRNSSVMLEAPHYRPKLYFTSNGPMPELAGKEEPFPEPDNQSKMKRSCENAEHVGLFTPNAGQHFRDEQRRRRSQYDRGTRLAALEEYDYETAIQQLYGGTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8R2</accession>
    <name>A0A367L8R2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8R2"/>
    <dbReference type="OrthoDB" id="4930473at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI10804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="95" mass="11224" checksum="83EA5B2381B908AD" modified="2018-11-07" version="1" fragment="single">ICYKDIRTFSRKKGEFNAFLTNLKDKIRTNKATFRNKENRIGFLFYSLEGKARKTLETHLLTKTKDNNLSYEDFCGYVKDLIDQIDRIDTQGYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8Z1</accession>
    <name>A0A367L8Z1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_5203</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8Z1"/>
    <dbReference type="OrthoDB" id="8115477at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016645166" description="Hydrophobin" evidence="2">
        <location>
            <begin position="19"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI10887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="217" mass="23846" checksum="DEC1C9B5283DEA84" modified="2018-11-07" version="1">MKCFAALSVLALAIGATAAPLEDNRYDDRFENKGFEAKGYEAKSYEAKGYEARGYDNGYRGRGRGYERGLENYYGPGYGYGPGNGHGRPREYKRAVQDKQAGYDRHWAPYHGRDYDGDYIGHERYDPTGDYEDNFNGNSRDTIGNSRDVVGNRGDTNGNRGDVCSAKSQQQVCCNGGLSCLVQLLGAPCETTAYCCDTHSGPGTAVNLNLLNCLKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9C9</accession>
    <name>A0A367L9C9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_5271</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI11028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9C9"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI11028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="168" mass="19280" checksum="514DEA4D07229D14" modified="2018-11-07" version="1">MTLTLQSYPMGLCIAWRPRRDRLGTPTYPLLACNTDPLPQPPRRPLLPLRLLLPATTPRPRLRPSIRLSRRRARPPPVMLMLMLLPVRRRRRCLSLALIIILFFSFSFSFFFFFFFSSSYSSSSFSLMSIHRRHSQASRHSATAAVAPPPPPTPHPHPHPPPLPRLTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9L0</accession>
    <name>A0A367L9L0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">OPA3-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_7288</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OPA3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9L0"/>
    <dbReference type="STRING" id="1330021.A0A367L9L0"/>
    <dbReference type="OrthoDB" id="2129069at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019216">
        <property type="term" value="P:regulation of lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010754">
        <property type="entry name" value="OPA3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499:SF0">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12499">
        <property type="entry name" value="OPTIC ATROPHY 3 PROTEIN OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07047">
        <property type="entry name" value="OPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="64"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="161"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="64"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI11121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="212" mass="24516" checksum="54F400CB15B79410" modified="2018-11-07" version="1">MVPLPLFKLAALFVRHVSKYGANRIKAQAHDHPRFRAFAARYGQSIHQLNMRLSVALLRDPEAERRAKEKAEAPTAKTEEQHRRDEAAKEKAKSKPSSVRRPGFVLQNVWRRKFRPLPEAKAVDLFADVLGDAFILTVAVGLILYEYWKASQKPDKNKERIDDLDRRCQELQKREDDLADAEEQHRQRLAILEEALRSLQDPKTKRPLLPTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAN9</accession>
    <name>A0A367LAN9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAN9"/>
    <dbReference type="OrthoDB" id="4867494at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016721937" evidence="1">
        <location>
            <begin position="21"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="134" mass="14070" checksum="6BA022568F6C378E" modified="2018-11-07" version="1">MPSAIKTVLIATLVAVRAAARPETTSSAPAGSPTPFCECGYTYCGSVLMAMDKPWTEKQLAEAYCKTPKASCSNGRPASDARSALYLCLCEDAGRRVGNRLHLLCGCDSCLVVGPDYRGRCETPCHAGGCAEGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAP8</accession>
    <name>A0A367LAP8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_7767</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAP8"/>
    <dbReference type="STRING" id="1330021.A0A367LAP8"/>
    <dbReference type="OrthoDB" id="60843at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF1">
        <property type="entry name" value="PROTEIN PHOSPHATASE PTC7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13672">
        <property type="entry name" value="PP2C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="73"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI11500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="385" mass="41385" checksum="BCAA7C7A142FD8E6" modified="2018-11-07" version="1">MATGLALRVSSRLRSHFLSHLRPSPVRPHRQGSFVSCYSTTTTTTPRLGFHLAASFSAKDRPFDPSTHVFHFESGSSPVTTRRPDSGHDAFFVSRVKGSDAVAFGVADGVGGWTESGVNPADFSNGLCNAMAVAASAASGPVTARKIMSHGYDAVCRDERVRAGGSTACVAIASSDGILDLANLGDSGFLQLRLNAVNAVSEPQTHTFNTPYQLSLIRPRLAARMAALGGSIPLCDLPRDADVYQHRLRHGDVILLATDGLLDNLFHQDILRIASRVMISSGAWTLTQTEGVRVADSIGTLVDQMRPTLDQDRLRKNSTTLQSLLATELVMAAKAASVNTKVDGPFSKQVRRYYPRERWHGGKVDDICVVAAVVCQQPTATESKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAZ4</accession>
    <name>A0A367LAZ4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dihydrolipoyllysine-residue succinyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.61</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">2-oxoglutarate dehydrogenase complex component E2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_7416</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.61" evidence="4"/>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAZ4"/>
    <dbReference type="STRING" id="1330021.A0A367LAZ4"/>
    <dbReference type="OrthoDB" id="5391403at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004149">
        <property type="term" value="F:dihydrolipoyllysine-residue succinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050537">
        <property type="entry name" value="2-oxoacid_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006255">
        <property type="entry name" value="SucB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01347">
        <property type="entry name" value="sucB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416:SF5">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43416">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE SUCCINYLTRANSFERASE COMPONENT OF 2-OXOGLUTARATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="2-oxoacid dehydrogenase acyltransferase catalytic" evidence="11">
        <location>
            <begin position="185"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="104"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI11589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="418" mass="46210" checksum="C5B677812F8739D2" modified="2018-11-07" version="1">MISRRIAAVAHHASIRSNCLHPSVYWLPPPAVKHHRRSFADTIVKVPHMAESISEGTLKQFSKGVGDRIDVSVNAPGSGTITEIFVHEEDNVVVGQDLARIELGESPNANEKNNEHAQELNEEENGNSLALAKDSESEPERHIEPSSRKDHAASQGRPTQKPNESSVDIHASHNTSPTYPVLSNREERRIKMNRMRLRIAERLKQSQNTAASLTTFNEVDMSHIIEFRRLYLDETLKKTGVKLGFMGAFSRAAVLAMRDLPAVNASIEGPNGGDTIVYRDYVDISVAVATEKGLVTPVVRNVELLDMIGVERAIAEMGKKARDGRLSIEDMAGGTFTISNGGIFGSLMGTPIINLPQSAVLGLHAIKERPVAINGEVKIHPMMYLALTYDHRLLDGREAVQFLVKIKEYIEDPRRMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBE6</accession>
    <name>A0A367LBE6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">YbgI/family dinuclear metal center protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_7567</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTP cyclohydrolase I type 2/NIF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBE6"/>
    <dbReference type="STRING" id="1330021.A0A367LBE6"/>
    <dbReference type="OrthoDB" id="3345469at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1390.30:FF:000001">
        <property type="entry name" value="GTP cyclohydrolase 1 type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1390.30">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002678">
        <property type="entry name" value="DUF34/NIF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00486">
        <property type="entry name" value="YbgI_SA1388"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799">
        <property type="entry name" value="NGG1 INTERACTING FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13799:SF13">
        <property type="entry name" value="NIF3-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01784">
        <property type="entry name" value="DUF34_NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="2">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602678-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI11562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="34297" checksum="1515EC7107DF8EDE" modified="2018-11-07" version="1">MTSSSSSSSSSSATRAWGAWQVRPASFTQLVVESMRKLYPEELADRSWDNVGLLLGNEDVEAKPSSSSSSPKVMVTNDLTFQVAVDAIRQGVSVIVSYHPFIFSGLKSITCKDAQQATLIRLARAGIAVYCPHTAVDAAPSGLNDWLAKIIAGPHDDDRSIAVPAASQSQTEVGYGAVGRFHAPVPLPEILLRLAARLGGLQHLMIASPVGAKVADISVRSFAVCAGSGYDVLEAVDVDLLVMGETSHHSALRAIQQGRTLVQVFHSNSERAYLREVLRPRLRELLTNKVPEAEVVMSEYDKDPFTVVDVRDLKTDEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBE9</accession>
    <name>A0A367LBE9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha</fullName>
            <ecNumber evidence="4">2.5.1.58</ecNumber>
            <ecNumber evidence="3">2.5.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">CAAX farnesyltransferase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">FTase-alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ras proteins prenyltransferase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Type I protein geranyl-geranyltransferase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L249_7677</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.58" evidence="4"/>
    <dbReference type="EC" id="2.5.1.59" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBE9"/>
    <dbReference type="STRING" id="1330021.A0A367LBE9"/>
    <dbReference type="OrthoDB" id="272289at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005953">
        <property type="term" value="C:CAAX-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005965">
        <property type="term" value="C:protein farnesyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004662">
        <property type="term" value="F:CAAX-protein geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004660">
        <property type="term" value="F:protein farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF1">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE_GERANYLGERANYLTRANSFERASE TYPE-1 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="NTF2" evidence="15">
        <location>
            <begin position="16"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="192"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCI11753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="701" mass="79110" checksum="0F38C956686CC09F" modified="2018-11-07" version="1">MTLPDADTEVKASSEAADTFVGNYYQALNSLSAIAPFYVNSSTRYSVKADLSINGKVLAAPDEYKAMLDAQGPNVLYEVESIDAHVINPSFSHDAPEHIHDEARVEKSGGLASIVVTIMGKIQFGKARDSLQQPFNETLVLVPNWDVMTRNPPRAAKRWLIMSQNFRALRALTILNYYQQQTSLPPFVMPAKAKGSTKAGVSDSQTTQPTIRPKTTASTPNETVEQRSQRRRLLTNPLEQRVRDAGLSSLSPAEKKTYAHSQLVLPVTENRIPLTSKAEREFWKVVNKDGLAARRLRLRYGWGQDRTGRDVGSYTVAEFEKRSLGQAKLTALDILHRAFLDRRARGRVDDEDVENEKARRLAMAALKRELYGEIVGSLAQDPEWDDVVPIPQSEPEDALAKIAYADDYAEVVSYLRAVMAANEHSPRCLRLTERVISMNPAHYTVWLYRFQLVCSMYLHIPDEITWLNQLALENLKNYQIWHHRQLLVEHYFPLIAGDDEAVRALGSSETSFIATMLAQDSKNYHVWSYRQYLVEKLGLWTATELASTQSFVETDVRNNSAWSHRFFLVFSDPAASTPESPATAYDAKVPASVIDREIAYAQDKILLAPQNQSGWLYLRGVLVKGSRDLESVAAFAERFVGDLGQANESVRSSHALDLLADVYKRRGDLPKARLCLQRLWEKWDPVREGYWKHRASQLEAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBP0</accession>
    <name>A0A367LBP0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBP0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="62" mass="6830" checksum="0FFD59DBA872319A" modified="2018-11-07" version="1">MGFNGLGLQSSQKRLVGSQATRRPSREKEDDKETEGRKKKKGGTVGVVSCRTVYNEEKASTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCF3</accession>
    <name>A0A367LCF3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_0883</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCF3"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI12095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="187" mass="20839" checksum="81EB74C0B2BF314D" modified="2018-11-07" version="1">MASTYIVLTYPYYQHHHSRANERSRWWLNGSRFCRSAIACLSRPFAGYAMWHRPRAASRLALPCHGHNLERAVSAAARSKDAGAACKKPAREGRARVTWEWHTTNATRLLDYFGRDGIRPQSYPGCFWKNTEIPTGIIAAQAQGTVSRAGLPALLLVTHLRPSSILSTSLFLPSHGLAPRAFNAIQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCX5</accession>
    <name>A0A367LCX5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCX5"/>
    <dbReference type="STRING" id="1330021.A0A367LCX5"/>
    <dbReference type="OrthoDB" id="5316527at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="309" mass="35039" checksum="865EEF6137641E54" modified="2018-11-07" version="1">MVDWSDEEWEALSEAEKREIEKEESEGAVYMFLPMPFSTVTVPQPRYRGSDPEWKTFYNINRSSKLQREVRADLVGIIHKVMLGNKEYVKFLGGENIKVGRLWLDITFPNRPPPKHYIHGLAFCNDGIYWSRQPIEASLARTLDETVYPKAVALTFWTFWSSLLRQNAQSIYNSFAANEPPSSFPINSNPSNNPGNKSNPPPSDSSNLDPSQIKRVLMTNPLEVNESIIDAEIRTALQAALKTLGSKWRPAGKPPNPGCFFVDGVVEYYGPRASIGLYVWAWYDPKLKVWTSINLRLKHAKPHVQSPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDB3</accession>
    <name>A0A367LDB3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GID complex catalytic subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glucose-induced degradation protein 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_0181</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the RMD5/GID2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDB3"/>
    <dbReference type="STRING" id="1330021.A0A367LDB3"/>
    <dbReference type="OrthoDB" id="1933281at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16652">
        <property type="entry name" value="dRING_Rmd5p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000143">
        <property type="entry name" value="Regulator of gluconeogenesis Rmd5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045098">
        <property type="entry name" value="Fyv10_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037683">
        <property type="entry name" value="Rmd5_dRing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044063">
        <property type="entry name" value="ZF_RING_GID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170:SF3">
        <property type="entry name" value="GH10162P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170">
        <property type="entry name" value="MACROPHAGE ERYTHROBLAST ATTACHER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51867">
        <property type="entry name" value="ZF_RING_GID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CTLH" evidence="11">
        <location>
            <begin position="195"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="RING-Gid-type" evidence="12">
        <location>
            <begin position="386"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="RING-Gid-type" evidence="9">
        <location>
            <begin position="386"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="141"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="157"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00075398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00080744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI12423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="441" mass="49678" checksum="C1506B896AF3FCBA" modified="2018-11-07" version="1">MTGGDDETLSPFAPLLAELARMRKSNLSSAIEDVDKIIELLSKTREQVAGNADAHKIGMAMTTLQNPVKALLEAITGDLKEVTKAQKSFGKALDKALPLRELPMETDAMADHPPLINRAIAMHLLREGQFSVASTVLREEREHRRHEEVVDVAMSSSDDDDDDDDDDDDDDGEEIKQEQNDDSNIRILSADLQDRFSEMYDILAHLKERNLKPAIEWARVHNERLEAKGSNLEFDLCKLQFVWLFKGPSENGLPDDENNGQSGALAYARRHFSRFQSRHAKEIQQLCCAMLYAPNLAASPYRQMFEINSAFDDVVSSFTREFCSLLGLSAESPLYMAVTAGSIALPRLIKYTTYMKEKKTEWTTENELAFETPLPESMIYHPIFVCPVSKEQTTEQNPAMMLTCGHVICRDSLHKIAKGSRYKCPYCPTEGHLRDAMKISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDC6</accession>
    <name>A0A367LDC6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0187</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDC6"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="246" mass="27496" checksum="73CA5D9F237DAB0E" modified="2018-11-07" version="1">MRGKVSNKARPVQDPTLPLPVLPPIVRSNLKISSFYPPPPPPVFFFLNRALRGNHDEVRRHDAVSVFTGHLLSNPIYQPTPPQSTNNWGCRYPPNPHHVFRNLHINLKPSSTAKIHSPAPVIGSSPLCHRYTYRPAPPPPPSALLVNIIQLVKKEKLTHAINRSREILSIRSPHTPLLFSSPFSLSSSSIMSSPLPPHPPPPARSTDLHKPQKPGEQAMTAAPCRVDSRTPHPLLNHTVWYQKRNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDR9</accession>
    <name>A0A367LDR9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDR9"/>
    <dbReference type="STRING" id="1330021.A0A367LDR9"/>
    <dbReference type="OrthoDB" id="3439027at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="249" mass="27646" checksum="EC8A0346A22B46A9" modified="2018-11-07" version="1">MPAESKIWCRRDSWPPTQVRLNPPMVKAYSDPRPLLEDIDDNPLTYFLTPSPDGDMDVFGDDDMDFDAGIEDAAHPRAIVRSVSPSSLEGLRKSQAGASSPDLDSDLPSTDDDDDDDDYVRFSPSRSMSSRFAPLRNLAIDGLKLRARSPPVFGNGLAPSASYPGLPRGKADAARAQRGALSSRSAQVRPRPTRRLWREPSPDVWSIEEETEEDVLKSEMVSDRREAVAVEQKAAKPKKRVRFLLPARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEG5</accession>
    <name>A0A367LEG5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_0547</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEG5"/>
    <dbReference type="STRING" id="1330021.A0A367LEG5"/>
    <dbReference type="OrthoDB" id="5230543at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39472">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39472:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="360"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI12811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="413" mass="45537" checksum="74BF06C43022C457" modified="2018-11-07" version="1">MSPGDMLPSWSEVQDRGRVNSNNNNNSSSSSSSSSSTSGVPHRGPDAASSLQQPLPPPLHQPQAAAARQYPPQQVHQHSALSQAASPSHHAFSSNSHPPPPQTQAQQQQHHHQYPGGMNGVNGAGMAMPGPAPTPAGHQAELNYIYGMVEELSKQLADNRRVTEDIVTCLGRVRSRARSHALNNDDLIASAADDLEADTQNLDSLVSILSEALEKSNHSRDANANLVSQFAHALALMLRQFHDYKARHVADMAAWHRSYRSQLDEARKENSRLREQVWEMNTHASRANECLRSFRRKYVDDDARWDRHAHDTAMRQELRFWKRMAMPELEDDDPYWSADDDIIDVAEKARQAALEQAAIQEQLVDSQRPDDDPECGPQPGGVAMQREEPAARAVPMPPPRPPSAASSTGSTGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEI0</accession>
    <name>A0A367LEI0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Isocitrate lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_0977</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-threo-isocitrate = glyoxylate + succinate</text>
            <dbReference type="Rhea" id="RHEA:13245"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="EC" id="4.1.3.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Can also use Mn(2+) ion.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEI0"/>
    <dbReference type="STRING" id="1330021.A0A367LEI0"/>
    <dbReference type="OrthoDB" id="4078635at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004451">
        <property type="term" value="F:isocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.850:FF:000001">
        <property type="entry name" value="Isocitrate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006254">
        <property type="entry name" value="Isocitrate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018523">
        <property type="entry name" value="Isocitrate_lyase_ph_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01346">
        <property type="entry name" value="isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631:SF3">
        <property type="entry name" value="BIFUNCTIONAL GLYOXYLATE CYCLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631">
        <property type="entry name" value="ISOCITRATE LYASE/MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00463">
        <property type="entry name" value="ICL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001362">
        <property type="entry name" value="Isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00161">
        <property type="entry name" value="ISOCITRATE_LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="8 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="106"/>
            <end position="108"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="247"/>
            <end position="248"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="462"/>
            <end position="466"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="496"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI12833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="576" mass="64158" checksum="7C83CB3A38EC0A6A" modified="2018-11-07" version="1">MAANNMLASPLEAKAEDDAYDKEVTAVENWWRRDRWRHTRRPFSAEQIVNKRGSLPIEYPSHVQAKKLWALLERRFAAKDASYTYGCLEPTMVTQMAKYLDTVYVSGWQSSSTASSSDEPGPDLADYPYVRQALSLSLPFSSRPHLLFPFHPLNKTKKTTTVPNKVGHLFMAQLFHDRKQRQERLATPRGKQRSSLPFVDYLRPIIADADTGHGGLTAVMKLTKLFVEKGAAGIHIEDQAPGTKKCGHMAGKVLVPVSEHISRLVAIRAQADIMGSDLVAVARTDAEAATLITSTIDPRDHGFILGCTNPSLKPLSDLMNAAEQDGKTGAALERIEQDWLAEAHLMLFDDAVLKAMASRPDGQRLAQQYKNNNNNNRSNAEARALARKLLGQDVFFDWDAPRTREGYYRLEGGCRCAVNRAVAYGPYADAVWMESKLPDYAQAKEFADGVHAVLPHQKLAYNLSPSFNWKTAMPPAEQETYIRRLAALGYCWQFITLAGLHTTALISDRFARAFSQQGMRAYGELVQEPEMELGVDVVKHQKWSGANYVDELHKMVTGGVSSTSAMGKGVTEDQFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEY6</accession>
    <name>A0A367LEY6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_0018</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEY6"/>
    <dbReference type="STRING" id="1330021.A0A367LEY6"/>
    <dbReference type="OrthoDB" id="1588579at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="155"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="332"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="10">
        <location>
            <begin position="80"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="408"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="427"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="473"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI12988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="484" mass="53032" checksum="CBF43BFEDDF6F327" modified="2018-11-07" version="1">MEKFPDHVDSLPYAPNGNGVEKPSSSMLTDRWTPARRDEASRSRQKSLSDAFRSMRSRNGSVSQNAHEIADALRAPVSPKLVILCLLWYASSALTNTSSKSILIAFDKPATLTLVQFAFVSSLCIFLAWLASLFPTLRSTVAFLRHPIRRPSSRVIVDTLPLAAFQIGGHLLSSTATAKIPVSLVHTIKGLSPLFTVLAYRIFYDIRYPQATYLSLVPLTSGVMLACSGKRAYDGQLLGVLQALLATLIFVTQNIVSKKIFNEAAKAEGTQSGKLDKLNLLCYSSGMAFVATLPIWFWSEGIALLGDVLHDGAVDLSNHPLAMDHGRLTLEFIFNGVFHFSQNMLAFILLSMVSPVTYSVASLIKRVFVIVMAIVWFRSPTTPVQAVGIALTFLGLYLYDRSNESNKADRKARSIAQSRGGSPLLPVDEKPTWNRHEKPDSGAHVYTEGYLGPDAAGYDYKKSDSRAGRGRSGRSSTSGWLPRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LF13</accession>
    <name>A0A367LF13_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">GTP-binding protein rhoA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_0391</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LF13"/>
    <dbReference type="STRING" id="1330021.A0A367LF13"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01870">
        <property type="entry name" value="RhoA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000329">
        <property type="entry name" value="GTP-binding protein rhoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI12822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="23939" checksum="F4EEA382DC7F180B" modified="2018-11-07" version="1">MAEIRRKLVIVGDGACGKTCLLIVFSKGTFPEVYVPTVFENYVADVEVDGKRVELALWDTAGQEDYDRLRPLSYPDSHVILICFAIDSPDSLDNVQEKVLCSRRRVFPPAADLPWQWISEVLHFCSGLPIILVGCKKDLRYDQKTIEELRKTSQKPVTPEDGEEVRKKICAYKYLECSAKTNEGVRDVFEHATRAALLSRTKSKKKKCLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFM9</accession>
    <name>A0A367LFM9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_0365</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFM9"/>
    <dbReference type="STRING" id="1330021.A0A367LFM9"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF466">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="213"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="267"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI13197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="323" mass="34439" checksum="B06F19E99518DD70" modified="2018-11-07" version="1">MGEGTARCERMALFAAGFNACGQLYLDVDTSRVEPEDLHSFTLILGGESIERPVARLSYTFVRLDGRLRMAGIGPDDEDVQEAASLFAEAANGEILVVQRESPLKSSKEAPGRPLLKYASFAAWRAGDVQQSWTPPSPVQTIAAYDTGFVILHQDGTVATSGDARFENCLGRHVTEQSPATKPGIVTDLSDLGELVKHVSASGYTLAALTESGAMYVWGLPPRGLKNRPGAFSTLDRVPNYVEIGNDKDVQDMAVGDSHALVLTTDGSIYVTGSNENGQLGLGKTARDELESWTNIAFQPPSGHRVVAVAAGPRSSFILTAAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFU0</accession>
    <name>A0A367LFU0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0349</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFU0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="166" mass="18541" checksum="DAF62140FB904515" modified="2018-11-07" version="1">MRDKYAEPYRLTIDGTLKVPCPGSLVSAWLRQGHQRFLGYRPWSSPPAREKIVSESPTAFSHPHASFCVPHYRTQMEKKRKKERKTIDDKTIQNLLSIVAREPCHTALSRMATPPPTPPQQRTTPNHRPVARGGSGMLVLLFAGCGAASRYCSSAPLLRIPVVLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LG93</accession>
    <name>A0A367LG93_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribose-5-phosphate isomerase</fullName>
            <ecNumber evidence="4">5.3.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">D-ribose-5-phosphate ketol-isomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Phosphoriboisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_5635</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate</text>
            <dbReference type="Rhea" id="RHEA:14657"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58273"/>
            <dbReference type="EC" id="5.3.1.6"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ribose 5-phosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.6" evidence="4"/>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LG93"/>
    <dbReference type="STRING" id="1330021.A0A367LG93"/>
    <dbReference type="OrthoDB" id="1555531at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00412"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004751">
        <property type="term" value="F:ribose-5-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006014">
        <property type="term" value="P:D-ribose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01398">
        <property type="entry name" value="RPI_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004788">
        <property type="entry name" value="Ribose5P_isomerase_type_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11934:SF0">
        <property type="entry name" value="RIBOSE-5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06026">
        <property type="entry name" value="Rib_5-P_isom_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75445">
        <property type="entry name" value="D-ribose-5-phosphate isomerase (RpiA), lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI13438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="292" mass="31547" checksum="339D38008B6A244E" modified="2018-11-07" version="1" fragment="single">LSLLPNELRLGNIMDGIAPSFESANLIEVAKKNAARQAVQDYLMPSFRYVGIGSGTTVQYVVEAILEQGPSFYSKMVFIPTGNERPSVNGAPIPIEVAFDGADEIDEDLNLIKGGGACLFQEKLVAVSAMKFVAVAALSVVTVETDYRKQSKRLCTQWKSIPLEVLPLAAPLVLQRLKLMGSSKAVLRSGLPGKAGECVTDNGMWIIDAQFPPLLLPRDLDYDQDGKGNNGYWEVGKLAAELLGIPGIVEIGLFHGFNGEQGTSLQKEFQAQKPVAAYFGMPGGEVYLQRPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGA0</accession>
    <name>A0A367LGA0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGA0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="96" mass="10126" checksum="D45CA5903421FEAF" modified="2018-11-07" version="1" fragment="single">TLTHTQGTRPEGLGGSRDAGPAAAGPRPPYVTEAERHNNVGGGYAVQRLRPYGPYGPYEGRNVGTGQARRAFFSNTISLRVSILPSLGTGTYGYGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGJ4</accession>
    <name>A0A367LGJ4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5481</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGJ4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="104" mass="12030" checksum="6877897B19765A6B" modified="2018-11-07" version="1">MARCSTLVCVDCSRKPFPESPKLENGSQKNDDAMTAKKINEEIRMKKKALPIIMRKRRWPTQMTEMKTRKHKGASLGRWERRMTDKECWKGTIKKKGHGNVGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LH41</accession>
    <name>A0A367LH41_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_8174</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LH41"/>
    <dbReference type="STRING" id="1330021.A0A367LH41"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030586">
        <property type="term" value="F:[methionine synthase] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050667">
        <property type="term" value="P:homocysteine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000027">
        <property type="entry name" value="FAD binding domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000007">
        <property type="entry name" value="Methionine synthase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF84">
        <property type="entry name" value="METHIONINE SYNTHASE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="7">
        <location>
            <begin position="177"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="125"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI13731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="595" mass="66122" checksum="CCFE9381858B52C1" modified="2018-11-07" version="1">MAASPPPESQPPLGPQTPSIAPSLTYSDESDDQDEPIRLENARARRASTRLIAQNASDIRRITGESTDEFVGRCCGGGCSMMSSNNEPISLPNNDAYRSLGLGITHIPTCLTKVTELPRKTLSFTPIPTQRGLPSPADSAISVGSDGPPARAGSPGPSDTVDTAIQPPRFVQPHHPFHVYPARIRAARELTKQGAEKRTFHVDLDITDYPDEESTDFKVGGAIGVTAPNCASIVDDIFDALMVPRFQRDRTVLMSTTKGRWPTVWGDDKPRELVTTRRDLLTWCSDLQSFPPTKPLLRVLAEYASADNEKKILMYLCSAEGQSRFYDLRTGPHITVSQLLHAFPSSQPPLDELLSNLPPLMPRFYSLSNDPHESCLVQDRKQHRLIEIAVTVHETSDWRGGRRTGVGSGFFERQARRFIQAQEAGDESPRLYIPMFKGLMANPLALQYNSDGPMLLIGAGVGIAPFRGFVQRRLKQANCRNKVWVLQGIRDSLVDEIYSGEWGVHEDEVKRVVESRRGEGRYVQEEVRNQADLVWWIINAVDGRVFVCGSSQGMGEGVEQALIDVAMAKGNLERDEARNFWKLKTDAKQYIAETW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHA6</accession>
    <name>A0A367LHA6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sulfotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_8009</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHA6"/>
    <dbReference type="STRING" id="1330021.A0A367LHA6"/>
    <dbReference type="OrthoDB" id="2405944at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053226">
        <property type="entry name" value="Pyrrolopyrazine_biosynth_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48419">
        <property type="entry name" value="SULFOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48419:SF1">
        <property type="entry name" value="SULFOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI13808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="38165" checksum="F7BC5439A00950E1" modified="2018-11-07" version="1">MASSVDLKAATNGINAMAKPNGTTASSDVANNDNANPLRPLFVATHPRACSTAFERVFMACRDELQCQHEPFSDAFYFGPEFLSDRYRDDAATRLASPAADATYKSLLDSFDQVQRQGKRVFIKDMAYYLFPPDGKPATIAPSLGGGSQSGNPTVLPLEALRRFHFTFLIRHPRRAIPSFYRCTVPPVSDTTGFTNFMANEAGYEELVRLFDLVIRERIVSPDNITVLDADDLLDHPEEAIRAFCLRTGIRFRPEMLIWGRDDADYAAKAFAKWNGWHDDVLKSTQLNGRSQAQKSCTVESEDQEWAEKFGTEAQKVIRDVVNANIPHYNYLRQFRMTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHL4</accession>
    <name>A0A367LHL4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Urea transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_8226</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHL4"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050277">
        <property type="entry name" value="Sodium:Solute_Symporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48086:SF10">
        <property type="entry name" value="AGR155CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48086">
        <property type="entry name" value="SODIUM/PROLINE SYMPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI13915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="350" mass="37244" checksum="5F3FA65A978F1B25" modified="2018-11-07" version="1">MVAREALGGFQVSFFTDVVQGALVLALVLVSAISVGVRANVVDRSLIASSGLTKPSLLGWQLLYVLPVAVTTNTFFVSSFWLRTFASRTDTDLRVGASLAAVVVASVLTAVGCAGLVAVWTGAWPGEPRREGSLALFALLERLPAWVVCVVLVMVVCLSTAALDSLQSAMVSSASYDVFGNRLAPRYVRGLVVVVVVPVVVVALKAVSILQIYLVSDLLSAATVPVLCLGLVDGMYWWRGFEVVAGGVGGIVAVFIFGLVYLGNARDAARLLILEHGLYTDDWSVFGAFVAAPLGGLVVGFAALALRLAFLFIRAKRRHERFDALDRPVGHFDDRQGRPEGIDAKAGKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHM0</accession>
    <name>A0A367LHM0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_8164</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHM0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI13933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="206" mass="23011" checksum="43473CA5F9EFC2D6" modified="2018-11-07" version="1">MPGTIRSRGAGKGEVGDIFLLDEIEHNNDSLGLPLTAPSPMKPPWESLMQYKSLLSIPITLRPRNCQSKNTSILLLCCRGYGSPPVTAYFRPQPTWFPSNLLTRQIVPMRITLRDRLLTGDSVRAVRPFPRSMQQQTGSAESYWGSKKNAVPPVFPSAIVCDLSGIVSYVRGSTDATKRAHALPPMFRRAKHLLAVRFFFFLELPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHN0</accession>
    <name>A0A367LHN0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHN0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="178" mass="19560" checksum="919918F15AF59A0F" modified="2018-11-07" version="1" fragment="single">MYETRRRGESNPAVQGLPPEPIINRSVGRDEQRRVPNCRTDDSRGRRRVNSESGSRHEREARVVQRACASRQRGVQEGKGREEMPQTGLRQLRWVDGFEEDIFIWLGEGGKAGMGGGGGGGGGGGGRVSVEVPSRVLCFESEPDQKARLDLSLIIDVSHSLFFLRTTHTMHAPGEPGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LI63</accession>
    <name>A0A367LI63_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor RfeG</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LI63"/>
    <dbReference type="STRING" id="1330021.A0A367LI63"/>
    <dbReference type="OrthoDB" id="4146887at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39609:SF1">
        <property type="entry name" value="RFEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39609">
        <property type="entry name" value="RFEG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="295"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="38075" checksum="42F3CA4BF9C407A7" modified="2018-11-07" version="1">MSRQPRTQAQTTQSTTRQNEYFVPRDGIDREVISADICRYLGNDALVRPGQYDNPQNGQTVHGYYITAYRNLTTAMIEDLKADSARWENERRAQTRNTGVQYRYSETHQSRQHHGPTENPFPPDPYNRDGGYENPRYPGTGAPGFTGASAPYSSPPPPQQQQQQQQPYQTSSGGPYAVGYQQNQQVPSSERFQSGQPASMLRPGYQTSQDPPYIGTGANLPHSGYASSNEHYGSRLSATVSAPPQPLYASAPPSQPPYPATSSPFQQYPNQPPATGGQVYGGVPSHESFYGRVSPAQAPQQAYAAQGQQYDATPPPPPTTSQTPTAGSSKRRNDSDLDRLHRPPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIC0</accession>
    <name>A0A367LIC0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Caffeine-induced death protein Cid2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_5917</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIX23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIC0"/>
    <dbReference type="STRING" id="1330021.A0A367LIC0"/>
    <dbReference type="OrthoDB" id="5593818at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019171">
        <property type="entry name" value="MIX23"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31905">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31905:SF2">
        <property type="entry name" value="PROTEIN MIX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09774">
        <property type="entry name" value="MIX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00024204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI14150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="24495" checksum="876548A8F12B34F2" modified="2018-11-07" version="1">MSSASPPATTKSGWFFAQRGSSQTPSPQKMSQIPERSSLTPQFCFSSGTLRGSSSIDDSISQNLNALLTPSQKGFDPDSTPRRTTARSIGRPACRSYCESVLFPAWQARTEVLDYCALVATSPDPDDPEAAIRDVEKQKDRERVVDERLDPYSGRFFPREARTQALAMLIRQERDVERIVRTQTWNVVRQRCTAVGEDFEDAVNRWRASGNDRRSQPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIH3</accession>
    <name>A0A367LIH3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Histone deacetylase complex subunit SAP30 Sin3 binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_8091</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI14052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIH3"/>
    <dbReference type="STRING" id="1330021.A0A367LIH3"/>
    <dbReference type="OrthoDB" id="510958at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038291">
        <property type="entry name" value="SAP30_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025718">
        <property type="entry name" value="SAP30_Sin3-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13867">
        <property type="entry name" value="SAP30_Sin3_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone deacetylase complex subunit SAP30 Sin3 binding" evidence="2">
        <location>
            <begin position="178"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI14052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="228" mass="23106" checksum="3F4DF0C848E8E21C" modified="2018-11-07" version="1">MAPVKASRNGAGDDHRPETGAGAGVGAGPGAASAGGGGGGTGGGPKERAVGAAASASASASASASASASASASAAAATPPAPSKMRRAASQTNMSQLVREAAAAPTSAPAPSQDAVNVVAPTVRFCTSPFSPFLRIRLADLLNAPSSFSSSYHQRVLSQPGSIGLYSPTMVAKRKSRRQSKEQLAMTVRKHFNGMGIQENDVMVDFMYRVRCERASSTSPHNKDSRNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIM7</accession>
    <name>A0A367LIM7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chromatin modification-related protein EAF3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Chromatin modification-related protein eaf3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L249_6153</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in deacetylation of histones, chromatin assembly and chromosome segregation. May act as a transcriptional oscillator, directing histone deacetylases to specific chromosomal domains. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MRG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIM7"/>
    <dbReference type="STRING" id="1330021.A0A367LIM7"/>
    <dbReference type="OrthoDB" id="124855at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.30:FF:000004">
        <property type="entry name" value="Putative Chromatin modification-related protein eaf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.30">
        <property type="entry name" value="MRG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008676">
        <property type="entry name" value="MRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038217">
        <property type="entry name" value="MRG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026541">
        <property type="entry name" value="MRG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053820">
        <property type="entry name" value="MSL3_chromo-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880">
        <property type="entry name" value="MORTALITY FACTOR 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880:SF15">
        <property type="entry name" value="MSL COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05712">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22732">
        <property type="entry name" value="MSL3_chromo-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51640">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MSL3 chromodomain-like" evidence="15">
        <location>
            <begin position="13"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="MRG" evidence="14">
        <location>
            <begin position="246"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="85"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00057322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF05712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF22732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCI14271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="433" mass="49916" checksum="BDA9BEE370B9F7D0" modified="2018-11-07" version="1">MPPTRQQQQAPPFSKDEKVLCFHMDMLYEAKIMDVQPGNKPSDGYRFKVHYKGWKNTWDDWVLADRIRPFDDEHKELAAQLHAQLKHSLQKMAKQPKKNPRNGGESARGSEERASSAAQGPRGRRGKDWELEQSLFVSSPTVGSPNTLSDGSSSNTTLSNFGRSSSHTSRSSRSQSCLVVKGKRYREVKDHLTELPKPNHRYLSASGRILFDDRYVMAPSVPPKVRQLRSHRAQTTSILQPAATIKEDAFHNKPMIIIPMPDHVQAMLVDDWENITKNNQLVPLPHPNPVNKILQDYLDFEKPHREQGSASMDILEEVIAGLREYFEKALSRILLYRFERHQYMNSRALWDNNTEETSKYKSVSDVYGVEHLARLIVSLPELLAQTNMDQQSVSRLREEMGKFNVWLSRNCETYFLNEYETPSQEYIDKARTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJH6</accession>
    <name>A0A367LJH6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5672 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_6623</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJH6"/>
    <dbReference type="STRING" id="1330021.A0A367LJH6"/>
    <dbReference type="OrthoDB" id="10025998at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043729">
        <property type="entry name" value="DUF5672"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18922">
        <property type="entry name" value="DUF5672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5672" evidence="2">
        <location>
            <begin position="120"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI14593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="347" mass="38408" checksum="D5E61386CF95A75E" modified="2018-11-07" version="1">MPNPNPTPLSLNTSLTHLSAALLLHLLLLTTATSILLLLLLLLLFLTPTSPFPSPNRLFNSSKLALLIEDRPLPILAPLVLHFTAVVPPDWLFLFLGSQASVSKMNASAAVRQRVRQGKLKLAAIPDNTSVASEEMISRFLTSSWLYEEAIAPAEWLLIFQTDSIICANSRVDVHHFLPYDWVGAPWNPTGEWGGNGGLSLRRVAPIRRILRSQHRVANSDPEDVWLSERLRYTPGSLMANGSVSLAFSAEIHAGPAGVDRLVLPRLVNGTILNDDGDFLQGMDDWRRGFYEPMGYHIGGGGVWLHGPVWGTPELRSHIWHYCPEVKMTLPMDVARFVPGECAARWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJK3</accession>
    <name>A0A367LJK3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA repair metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_6378</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJK3"/>
    <dbReference type="STRING" id="1330021.A0A367LJK3"/>
    <dbReference type="OrthoDB" id="262529at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16273">
        <property type="entry name" value="SNM1A-1C-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12650:FF:000007">
        <property type="entry name" value="DNA cross-link repair 1A protein, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000038">
        <property type="entry name" value="DNA cross-link repair protein pso2/snm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011084">
        <property type="entry name" value="DRMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240:SF6">
        <property type="entry name" value="DNA CROSS-LINK REPAIR 1A PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240">
        <property type="entry name" value="DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07522">
        <property type="entry name" value="DRMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="8">
        <location>
            <begin position="349"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="DNA repair metallo-beta-lactamase" evidence="7">
        <location>
            <begin position="599"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="48"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="111"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI14615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="786" mass="87075" checksum="D3623B23472327A3" modified="2018-11-07" version="1">MVASASLNRMNTPRRTAANGARFSKKASKPNASILSFFQKVHKEEESLFVGSRQDPQPCNDDIYGNDDRRFNESELPSKKPRLAEEPTVKEQLTVETVQKTRAPTRMPFILDSDSEGEDDAHGLEAPRTTVPKTEDLDFETRNEQLSLERQSSAEAQLENVQDLDRLDLDGFEGEELRERRFMLEQARLEAEEADDDVDDALDDAATEIATEESCPICNGSLAGVSADDATRHVNSCLDGNPIPLPVADLAPDEVDSAQVGKRFARAAIPRPAQANPFELDGGGAVEAKNSAFSKLMSNKAEDSAWTTAAAAEHASRGRPAYERTCPFYKIMPGFNICVDAFRYGAVQGCEAYFLSHFHSDHYMGLTANWRHGPIYCSKVTGSLVKKQLRTASKWVVELEFDKPFDVSGTGVTVTMIPANHCPGSSLFLFEKPLGGGRMRRILHCGDFRACPGHITHPLLRPDVINSVSGKKRQQTIHMCYLDTTYLNPRYSFPPQDDVIKACAELCASISPDPESHDDVWEQSAGSGEAQTMGKYFTSNKPGKKTVGGAKLGQRLLVICGTYSIGKERICIAIAKALKTKIFAAPAKMKICKQLDDAELSGLLTSNPVEAQVHMQSLMEIRAETLKDYLASYRPHFSRIVGFRPSGWTFRPGNGKSFGANTPPSSVPTQQILHGKGWRTRFGCKDLVIQRGSTKEAMCFGVPYSEHSSFRELAMFVMGLRIEKVIPTVNVGSEQSRKRMKGWIDRWMAERRRGGLVVPMVEEETDEKEELELWDGKTAQGGGVWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJQ3</accession>
    <name>A0A367LJQ3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJQ3"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="98" mass="10862" checksum="E5F868070289C4A9" modified="2018-11-07" version="1" fragment="single">WVGVGACVRAWAGVELQDVSFLSRAEHSLPAEEERGKKKRVVHRYRDSCSNGFTYYVFLRPVIPPSDEPTSSSFPSPARSPPSSSAIPFLNITPSFSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJT5</accession>
    <name>A0A367LJT5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Gfd2/YDR514C-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_6438</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJT5"/>
    <dbReference type="STRING" id="1330021.A0A367LJT5"/>
    <dbReference type="OrthoDB" id="5953249at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040151">
        <property type="entry name" value="Gfd2/YDR514C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048519">
        <property type="entry name" value="Gfd2/YDR514C-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28083:SF1">
        <property type="entry name" value="GOOD FOR FULL DBP5 ACTIVITY PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21762">
        <property type="entry name" value="DEDDh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfd2/YDR514C-like C-terminal" evidence="2">
        <location>
            <begin position="300"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI14684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="508" mass="56866" checksum="E48BA9B38E60A846" modified="2018-11-07" version="1">MADSDPDLSLLQDVLGRAVTLKDPGIGIENTHETATKPLREHREPRWEQVHAKEEPRNGKCKPTKSSARIQSSAPEPADPISIDCSALLVDDMVPCDVEFCPVPEILAYPHFFIGKGNRPRAKPFFDDYLGRQSWDIFWMYDPRGNHPPWPDIFLLTAQFEAFLRAINEELNTALTIPSGGNRKKFCRRFGGGGTPRPRFLLRSVDRYSLDKHSLGEIPWPQPLQSDAEAFKKASTAAQDDFLSNLHPQGCDDGKNENKKDKTQKAKERSRKRALFRQSMMHQAQTFLGLRNPGSSDSVVFVCVDVEALEAPPHPVSEVGIAILDTNRLSGTPPAAAGSGWWPFIEAHHLRTKEYSGMVNFKYVMGCPDAFDFGTSEFPTKKELVNAVRCILKPYMDQERKLVFVGHDTASDLRYLSQMGLDMMKLPGMVCEIDTKALHQAWQNSDDGRSLSALLSDLNIRSNNLHNAGNDAVFTMRAAIGLATEQVRKDEADLRGDGEKYVPSLWET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJU2</accession>
    <name>A0A367LJU2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6787</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJU2"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="107" mass="10966" checksum="FDB56B95F5A4D91F" modified="2018-11-07" version="1">MHQTMPRISRENMGGRGSAGGDGGGGGGGGDDDSAARDSGKWRVSAGGTLNDGPGCLAGGDSLGMTDRGRKGEGRRWLVVFLPPSHKLAKPNNNNNNINSQSSFPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJV5</accession>
    <name>A0A367LJV5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6435</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJV5"/>
    <dbReference type="STRING" id="1330021.A0A367LJV5"/>
    <dbReference type="OrthoDB" id="3938623at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045142">
        <property type="entry name" value="BCAS3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13268:SF0">
        <property type="entry name" value="BCAS3 MICROTUBULE ASSOCIATED CELL MIGRATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13268">
        <property type="entry name" value="BREAST CARCINOMA AMPLIFIED SEQUENCE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1060"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="552"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1066"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1079"/>
            <end position="1088"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1149" mass="122702" checksum="6C622A397607422B" modified="2018-11-07" version="1">MPRSAKGLKKRGRESGGIAATVTKHAAGRFSSRPPSEASSSPATNTPEIHPSPPDHDQHGASPLLEALSATSASASTAPSMANEWARGVMDCSPSNLINLTSESPPTQPSSYEDSARAHRNWTAQRALRSPSPAPSSPPRSGRRPLSFQMEPPCQDAFITSPRAVSTAAFRRSSLYSQYPGSQPPLPHQPQPHFYGVAGLDLTITPQSGGIRAGDRGLFFGFDCIPPADGSPGAEKVALAGYEGGLQVYAVSKRGVDLVASLRGLRGGVYHAKILPWAVAGQDPSPYPLVAVVLHGPVVPTRPADGRQQDDGAGDGSSDDVFAHHDGIPARQLPAPLAYQTSVEVYSLKTNKLVDVLLQAQKIPNNGEVSLSSPLFQPPPPTGALTIKADSGNVVVCSGVTGECWTYRQLLQPQNGHTFACTGKLWTTLQQSQRADVAEESDKMHSPKSARRPTPQAPVLALNGHWMAYCPATPSSQISLRAHLPVPVLGRAPGVSSLTPPHLPVVTSSVDLPISDSVVNKIMRETTQELIQGAKWVGQQGLQAWNAYWNKPSSPQSQSQSQPPSQSQSQSQQQQQQQQQQQQMARSPPPHWVGSRSPQNDAPQFPPTHGAAVQPTTKEPGLVSIVDIEALGGSTSIHPLSTFATPLGCSFLSFSPSSLALFTASTKGDVQTVWDLLRIQHTHSSPLQTTLSHGDCGGPVVRQIAQFSRMTVARIVDVAWTGPLGERLAMVTERGTIHLLDMPFSAFMWPPPRRRKVMAKTAVEPPEASSSAVSIASGAFGAAYQAAKPFVTRSRRSSSNAGIAVAAPAAATGPGNMLRDSAAQGGRAIAATISHSLGKTSTAISQLRHTGENRVSLPHGTALPSAACVSWLKSRKSQVLISVGGGTLRMFPCKARRPSAAASGKRIARAHRYKDIKVPLLPDDVVAPFVRQVLESGVPDEYLELSDGEPEVGNTMTLHSQSRGAPAAFGMDATIPQAEIESSAPYQPFHTDRRVIFCAYGRCGMTAAAQLETASMLLASASLEEGPAPTRLRHPDRDQDTVSSVWAFGQNMAAVRLSMGLPHGVDDDDRDDGDDYDDERAGPEDHRALPPSAMERVMQFADEEQIVVTTRRRRKAHQGDADEDGFFEDDCEVLDFADQRVLDFADQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LK49</accession>
    <name>A0A367LK49_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LK49"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="66" mass="7047" checksum="3FF1B1309B542594" modified="2018-11-07" version="1">MSGREKPGSSNCDLDQYGGSEVPLKLSSSSSSSSSSSSPVISQNEREHGGEYRLPLELRREICAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKB7</accession>
    <name>A0A367LKB7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_6644</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKB7"/>
    <dbReference type="STRING" id="1330021.A0A367LKB7"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009385">
        <property type="entry name" value="PRK12744.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF7">
        <property type="entry name" value="RE15974P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI14876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="246" mass="26206" checksum="85DA06819B0200C2" modified="2018-11-07" version="1">MSLQGKVALITGGTKNLGAEIARQLALCGADLALHYNTDASRPSGEDLARELTSTKVKLYQADLRTEAAVDKLFDQTLSDFGRVDIVVNTVGKVLKKAIGDVTEAEYDDMFAINSKSAFFIMKAAAKHVADGGKIINIVTALLAAFTGLYTSYAGSKAPVEHFTRGVAKELSARRVSVNSVGPGPMDTPFFYPQESPESVAFHKSMGMGGRLTEVGDIAPIVKFLCTEGAWISGQTIFANGGYTTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLA7</accession>
    <name>A0A367LLA7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_6949</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLA7"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI15191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="383" mass="43159" checksum="901A97C5E7B4E185" modified="2018-11-07" version="1" fragment="single">TRPEGLGGSRDAGPATAGPRPPYVTEAVRGGYGTATPYSGYGRTGRTGHRGAFRAAAGPEGLFNHRLPRGGEDEGPAPADLAAFFFFFFFFLLTTAGELTADSTLFFFDLCRYGYGYGKRPRCYNTATATANALVATVPLLLLLSLSNALFGPIFSAAFFVLCDDRNRVRIRIRIRIRIRVRIRNEIDSRIRVRAKSSSHNSRYDSRYNRNNSSIRTYLRPYRTYAPYSRYLRPQSFVVLFVLTEDLPWPAAKIALLRYYGAFNQIRTVSFYDKLRRHEARRPKTKDTIDWLEKHAFLSGFSFLFLPSFPFFVFRPAYAVGSTRPEGLGGSRDAGPATAGPRPPYVTEAVRHSGYTRRLRHGYAVQRLRPYGPYGPYEGRNVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLK1</accession>
    <name>A0A367LLK1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_6717</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLK1"/>
    <dbReference type="STRING" id="1330021.A0A367LLK1"/>
    <dbReference type="OrthoDB" id="10058185at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000252">
        <property type="term" value="F:3-beta-hydroxysteroid dehydrogenase [NAD(P)+]/C4-decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF447">
        <property type="entry name" value="HYDROXYSTEROID DEHYDROGENASE_ISOMERASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06450)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="3">
        <location>
            <begin position="74"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI15313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="471" mass="51231" checksum="B8573FC426EE1C7F" modified="2018-11-07" version="1">MCGFTVAIALLVAASLMLYGLHVNRLMTQTPPEVLDDLEPPLTRDRARLIYKRVKEHGINWTANLPPAKNRRYLIVGGSGLVGWHIAQCLQATGVPRRAIRIVDLKPPADGGEMSYFKADITSQSSVDAAFVKAWPTAVSGLPLTVFHTAAVIRPFERDGVFYPRCGRVNVLGSAHVLAAARKAGASVLIFTSSSNAGASGVDWLYPPWIRRPRAMAQHIGEDDFWQPLRPARQFPSTYAVSKAEAERMICGADGAGMRTGAIRPGNGVYGDGTDHIISLMLARRQVLTCASPWVQNWANVRNVAQAHLLLEAALLGGQADRVAGRPFMITDGGPPLRFQDLYTLLSATSSTGFRVWQPTPVLTLLVAYGIEAYCRLLARAGPLRRLMGEPKGLVRYLQPGTMSSSVTTIIDDSLARKRAGEGGLGYRPACTSLEGLCAQVQDWNERVRAEPSTSPHACFHAEVETEVKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLS2</accession>
    <name>A0A367LLS2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Translation machinery-associated protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_6507</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2 4">Interacts with the 40S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="4">The SUI1 domain may be involved in RNA binding.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the DENR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLS2"/>
    <dbReference type="STRING" id="1330021.A0A367LLS2"/>
    <dbReference type="OrthoDB" id="277199at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11607">
        <property type="entry name" value="DENR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050318">
        <property type="entry name" value="DENR/SUI1_TIF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046447">
        <property type="entry name" value="DENR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005873">
        <property type="entry name" value="DENR_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048517">
        <property type="entry name" value="DENR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01159">
        <property type="entry name" value="DRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789:SF0">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21023">
        <property type="entry name" value="DENR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="SUI1" evidence="5">
        <location>
            <begin position="101"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI15361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="194" mass="21326" checksum="001353B40C28DE52" modified="2018-11-07" version="1">MADAEQPEAEPQGRHIVYCGVCTLPPEYCEYGGTVKKCQEWLQSNKPDMYSRIWSAEALEVATASLSVEAQARAAKDAQKKTAKAEAAEKKEADKLAKSVVTIKRIERNKKKFVTAIVGLEAFGLDLKKVAKDFGKKFATGSSVTKVPSGGEEIVVQGDVSDEVEEFILEKYKEIPEDNIELVDDKKKKKAAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLT2</accession>
    <name>A0A367LLT2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphatidylinositol-specific phospholipase C X domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLT2"/>
    <dbReference type="STRING" id="1330021.A0A367LLT2"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08586">
        <property type="entry name" value="PI-PLCc_BcPLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF113">
        <property type="entry name" value="SI:DKEY-266F7.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidylinositol-specific phospholipase C X" evidence="1">
        <location>
            <begin position="131"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="451" mass="49685" checksum="71FFEED3DAECF59D" modified="2018-11-07" version="1">MAKLSVRNLGIHPIELTAYERVERARPGGFFRGLFNGSSHPVVPDGEGEEKGVDEDAPRAEGSLALALPPFTVCPTHFPAPSSDEALRLTFKSSSSSSSTRLRLTVVYFPSVAVLAVLSSANLERWMADLHDDWPLTLLSIPGTHNSPTCYKALPSVRCQAVGIADQLRNGIRFLDVRVSAHPTETTLTLVHSIFPVSLTGSKYLDNLLQDAYRFLHENPSETILLSIKREGTGKATDGQMAKHLKHAYVDKTRHLWWTEPTIPTLGQARGKIVIIRRFALDDDMRAACWDGRGWAIDAQQWPDNCEDGNGGNGCFRIQDFYEVSESQNIEKKIAFSRCQLERASEQVFSLAGMPAHRPDAPVPPFFVNFLSASNFFNASCWPERIAAKVNPAAFEYLCVKHGQEGEGPQKLKVGSAGTGIVVTDWVGANGDWDLIRCIVGMNARLQLNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LM15</accession>
    <name>A0A367LM15_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LM15"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="129" mass="15208" checksum="CFB32E1C2598C109" modified="2018-11-07" version="1" fragment="single">GRKKKKKKKKKKKKKKKKKKKKTKTKTKTKAESGSLWKRWKRPGAVQEFVETEVGFKNQSKEFCRDTSFVFLRHAFWEDGKKMHPFGSVPAIPPLRPDRPDSDYRNIRSWCSCCRSPPCSFLQLYLTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMF8</accession>
    <name>A0A367LMF8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 14">6-phosphogluconate dehydrogenase, decarboxylating</fullName>
            <ecNumber evidence="10 14">1.1.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L249_3357</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10 14">
            <text>6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10116"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="1.1.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10 14">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10 14">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="10 14"/>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMF8"/>
    <dbReference type="STRING" id="1330021.A0A367LMF8"/>
    <dbReference type="OrthoDB" id="434986at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000002">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.320:FF:000002">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000007">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006113">
        <property type="entry name" value="6PGDH_Gnd/GntZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006184">
        <property type="entry name" value="6PGdom_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00873">
        <property type="entry name" value="gnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006765">
        <property type="entry name" value="PRK09287.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000109">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00461">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="5 10 14" id="KW-0521">NADP</keyword>
    <keyword evidence="6 10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 10 14" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase C-terminal" evidence="15">
        <location>
            <begin position="209"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="40"/>
            <end position="45"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="63"/>
            <end position="65"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="105"/>
            <end position="107"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <begin position="159"/>
            <end position="161"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <begin position="216"/>
            <end position="217"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="478"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="484"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCI15623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="521" mass="57070" checksum="A409CA6DD255FF77" modified="2018-11-07" version="1">MSGPVARLANLRLGGVQLTSSVASDHGTDNVASADLGLIGLAVMGQNLIMNMADHGFTICAFNRTVSKVDKFLENEAKGKSIVGAHSIQEFVGKLKSPRRVMLLVQAGKAVDDWIANLLPLLSPGDIIIDGGNSHFPDSNRRTQELKQKGIRFVGSGVSGGEEGARYGPSLMPGGNEEAWPHIKEIFQSIAAKSDDEACCEWVGDEGAGHYVKMVHNGIEYGDMQLICEAYDIMKRGLGLSNKEMGDVFAKWNKGVLDSFLIEITRDIMYFNDDDGKPLVEKILDQAGQKGTGKWTAVNALDLGMPVTLIAEAVLARCLSGIKEERVQASSKLEYVSRCGGKFDGNKEQFLDDLEQALYASKIISYAQGFMLMQEAAKEFGWKLNKPSIALMWRGGCIIRSVFLKDITAAYRKQPDLKNLLFDDFFNKAIHKAQPGWRDVVAKSAELGIPSPAFSTALSWFDGYRTKDLPANLLQAQRDYFGAHTFRIKPESANNKYPEGQDIHVNWTGRGGNVSASTYQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMN1</accession>
    <name>A0A367LMN1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Golgi SNAP receptor complex member 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_3458</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of several multiprotein Golgi SNARE complexes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the GOSR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMN1"/>
    <dbReference type="STRING" id="1330021.A0A367LMN1"/>
    <dbReference type="OrthoDB" id="422156at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048219">
        <property type="term" value="P:inter-Golgi cisterna vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023601">
        <property type="entry name" value="Golgi_SNAP_su1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21094:SF2">
        <property type="entry name" value="GOLGI SNAP RECEPTOR COMPLEX MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21094">
        <property type="entry name" value="GOS-28 SNARE- RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027109">
        <property type="entry name" value="Golgi_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="94"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR027109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI15669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="233" mass="26129" checksum="1659915230D1D5A6" modified="2018-11-07" version="1">MATASAASPSGSAGWAQLRQQARTLETQTENLFHTYAQFSSSATIPPKPTDEERETESNIEELLEKRETVIAHLARLLDSEAALSSSALKQNNLSLLREKLASHRRDLSRLRSSLLQARDRANLLTNVRSDIDQYRANNPEAAEAEYMLNERSRIDNSHDMADSVLSQAYAVNDNFVLQRETLASINRRITLAASQVPGINNLMGRISAKKRRDGIIMGCFIATCFVVFWWFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMN4</accession>
    <name>A0A367LMN4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMN4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="418" mass="46741" checksum="C0E8E6222A7396DF" modified="2018-11-07" version="1">MLAGPSPSALCLSLSAFCAENPAIIHHIIDYSHHNDICSGRNFPSSDSNTHSTPSTSILCLPLTHTDPSLTMPTTAAADEDINQSDLAQVLLATRCSAELHNCHAEENKLPPPWKPNSTNSSQNFPPCSTPSTPRPPLKPRLRIHPPPLRQRPPLLPKKSRQESYLLPARENLSRAATAIRRLILQPFLNIVSPSVVSPRENYSFNASRNVNTTRRRLLNTYRDTPTMRSRRGYIKFPSSIRPSPSQCRLMSLLPWHVRVGSARCHLRRSPVAIFVARPLPMRDAASETDTAYRSNCGPTQNMTRKGKKAIQKVEDKTNPAYRIHLRRSVERRDTNGADPESRGTHGHAAPRWITCWDRNTSYAPKAKVCLAGGAPVTTRTAPISTRAEKEHHLPPRHRFSKLAAMRSQQQLRCAQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMN9</accession>
    <name>A0A367LMN9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_3481</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HTATSF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMN9"/>
    <dbReference type="STRING" id="1330021.A0A367LMN9"/>
    <dbReference type="OrthoDB" id="10258585at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12281">
        <property type="entry name" value="RRM1_TatSF1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12285">
        <property type="entry name" value="RRM3_RBM39_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000105">
        <property type="entry name" value="HIV Tat-specific factor 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.70">
        <property type="entry name" value="Proteasomal ubiquitin receptor Rpn13/ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044868">
        <property type="entry name" value="Rpn13/ADRM1_Pru"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038633">
        <property type="entry name" value="Rpn13/ADRM1_Pru_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038108">
        <property type="entry name" value="RPN13_DEUBAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034393">
        <property type="entry name" value="TatSF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034392">
        <property type="entry name" value="TatSF1-like_RRM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15608:SF0">
        <property type="entry name" value="HIV TAT-SPECIFIC FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15608">
        <property type="entry name" value="SPLICING FACTOR U2AF-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04683">
        <property type="entry name" value="Rpn13_ADRM1_Pru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51917">
        <property type="entry name" value="PRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Pru" evidence="9">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="495"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="141"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="437"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="577"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="187"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="447"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="577"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI15704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="757" mass="82527" checksum="E35B01BE8CA5723A" modified="2018-11-07" version="1">MPVHPIITFKAGQCEVDTASTPHKVKPQTQAGYIYLYSEDDLVHFCWRKRSDTLEDPQIDLVMVPTDGSFVPYEASQPAAQTNGRIFVLKFASSSQRHLFWMQSKPQSRVGDPSWFSPRDRKIGSIVHRLLQGQDVNVTAELAAVRNPGDRRDDDDEPMEDAEGLRRPHDHPGSGSGGAGPGATGGDIREEGEGSREGGADGARAADAAVANLLRSLRNQPGSTNQRGDIAYPSLVHLLPPSETVSMVDRASPELVDTLLDLLPPAVVVLASGLSDFGGKPEPTTEAVTTARQSLSLNEKCDLLKKVLRSPQFYQALGSLTMALRDGGLPGVADALGFSVENGGYITDSNMPLGGGQAIKAGAFVPPAKTNAEATSSASSATFTAMDVDFPTCPDDFQDDERISYSKKDEKFIAVHDDGTEFEFDAELKQWIPMDEESDDAQDIGGDEPKSEADDGNAKKRRRSDAENEPEKTDSSASARPRKKPKPAPKPKQNTAVYVTGLPSDATVSEIHEVFSRKGGLIAEEIDSKAPRIKLYKDDKGNFKGDALVVFFKPESVSMAIMLLDDTDFRYTAHGKGEGRMRVQEADSSYKKVQQEDRKDGEPRGEGEVGRPRQSQDRRKVIKKTQKLDAKLADWSDDEDDRFAGLVAPAKAQGPRTVVLRQMFRIFELEEDPASVLEIKEDIRDECSKMGLVTSVVLYDQEPEGIVTVKFQEAEAAAKCVKVMGGRPFDGRVVNAAFATGQESFRRTGATEDSRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMU9</accession>
    <name>A0A367LMU9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_2911</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMU9"/>
    <dbReference type="STRING" id="1330021.A0A367LMU9"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000024">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="8">
        <location>
            <begin position="74"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI15739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="597" mass="64596" checksum="3E1188E9EE74DE08" modified="2018-11-07" version="1">MMDHLGTLQPWSWKLLLTAMTTLSLVFVAGGWLLRRLRPYDAEEQAVDYSVPTPEPPSPERTVKRTGIRMEGSSAVQCYAPATGRFLGLVNPCSAAAVDRAVASAGRAQVGWCRTSMAQRRAVLRSLLRHVVQHGERICRVASLDSGKTLADAHLGELLVTAERIRWTISHGEMALRPERRRTGSPLMLQKRNWVRYEALGVVASLISWNYPFHNLMGPVVSALFAGNAIVVKVSERTAWSASYFCAIARGALVAHGHDPMLVHALVCWPGPASHLVSHPAVSHVTFVGSRPVARLVASAAARVPKQVVAELGGKDACVVLESAADDLGRIVEIILRGAFQAAGQNCIGIERVVASPSVYGRLVAALEPRVRHLRLGPEADVGALISDEPIRRLEDLVEDAVSRGARLLVGGHRHVHPRYPLGHYFEPTLLVDVRPDMPIAQTECFAPILCLLRSPSDRPQDLLAIANAPDFGLGASVFAHERDPSLQPVVAGIRAGMVAVNDFAAFYPAGLPFGGVAGSGYGRFAGPEGLRGLCNAKSVCEDRFAWLGVRTAIPKPFRYPVPAQQRAWAFAHSLVELGYGELSVKARGLVRLVQNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMV2</accession>
    <name>A0A367LMV2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome P450 monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_3446</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMV2"/>
    <dbReference type="STRING" id="1330021.A0A367LMV2"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF227">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="360"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="372"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="382"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="521"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI15717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="581" mass="64722" checksum="D6AC91F7DDA0BADA" modified="2018-11-07" version="1">MDKVVLVFVSWGAATALESGRLALTITSLALFWAVWTTFVYPHRVSPLRRLPEPEGAHWLLGHAPRLVGPTAGGPFREWITQMDHDGLIRYRFAFNRERLLVASPRALAEVLVTRSYDFRKPAAVRTTLSRVLGNGLLLAEGEEHRRQRRGLQAAFHFRHIKRLYPIFWDKAGSVVRAMTAACGEQGRAVLELNSWASRCTLDIMGVAGMGCEFGAVEDGDDSDLMPAYVSLSTPSSDARLLLVLGSFLPGWLVRRIPLRRNGVVDLAASRIRAVCRRVIREKRARLMSREMKTMEGEEKQRDGDMLSVMLSGGLFSDEELTDQFMTLLAAGHDTTASALTWVAYQMARHPDIQSRLRDEVRSRLPPPPPSLSSSSSSSSSSKRDEGQEAEEKVVTSSQVDGMPYLQAVCSEVLRTYSPVPMTMREAVRDTVIQGQRVPRGTKVVVSPWATNVDGRIWGADAGEFKPERWLLHQRGRFLSRGNGHEDSSLRSYGNNDDDDDDDDSISNYGFLTFLHGPRSCIGANFARAELACLVAAWVGSFAFELVDERLMDEKRLDFKMGVTARPAGGMPLRVRVVEGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LN04</accession>
    <name>A0A367LN04_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_2773</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LN04"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI15825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="123" mass="13761" checksum="BC285CC3A43B502B" modified="2018-11-07" version="1" fragment="single">LTRDSALPLPFSNRDKDPILNPRESFLELSDLFLSSELSDFSIDTLSNLLFNNSKGNKAAKKIAAKERKTTTKKIVVARKYTKPSFKNPTLFCAKGRRLRVLVVPSKVRDAICVLCLTSSLEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNA9</accession>
    <name>A0A367LNA9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C4-dicarboxylate transporter/malic acid transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_2524</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNA9"/>
    <dbReference type="STRING" id="1330021.A0A367LNA9"/>
    <dbReference type="OrthoDB" id="2901184at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015140">
        <property type="term" value="F:malate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09317">
        <property type="entry name" value="TDT_Mae1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030185">
        <property type="entry name" value="Mae1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31162:SF0">
        <property type="entry name" value="MALIC ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31162">
        <property type="entry name" value="MALIC ACID TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI15933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="456" mass="50289" checksum="0331673B25172D72" modified="2018-11-07" version="1">MATTHVVTSQSEMRTWSPTGDSTRRNSATLTATSSGRSFTMEKEQQQQPHHRHLEPGFYYYPGDKAAAGDGTSVEAQHAKIDPNDPNRPRLPLRQRLHHFTWAWYTLAMSTGGLAVLIFAQPHQFKGLRTIGLVVYVINLFIFTTISVLLTARFFLHPGDLSNSIKHEREGFFFPTLFLSIATIITGTDRYVIPKNDVALTWAVQGAFWVYLAFTLIVAVGQYSYVFASHSFGLQTMMPTWILPIFPIMLTGTIASVIADTQPEIAATPIVIAGLTCQGLGFAVAFMMYAHMVGRLMQSGLPNREHRPGLFMCVGPPSFTALALIGMANGLPEQATSTAQGTFLDTGVIRTVALLCGIFLWALSLWWFGIAAVAVIASPPKYFHLGWWAMVFPNSGFILATIAIGKALGSEGVLWVGTGMSIVLLITYFTVLFFNIRAVIVQDIMYPERDEDVVDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNE5</accession>
    <name>A0A367LNE5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PHD finger-like domain-containing protein 5A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PHF5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNE5"/>
    <dbReference type="STRING" id="1330021.A0A367LNE5"/>
    <dbReference type="OrthoDB" id="10248186at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005345">
        <property type="entry name" value="PHF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13120">
        <property type="entry name" value="PHD FINGER-LIKE DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03660">
        <property type="entry name" value="PHF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016468">
        <property type="entry name" value="PHF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="110" mass="12445" checksum="8BA5F9730B14FB11" modified="2018-11-07" version="1">MSRHHPDLVMCRKQPGIAIGRLCDKCDGKCPVCDSYVRPTTLVRICDECSFGNYQNKCVVCGGEGISDAFYCFECTRLEKDRDGCPKIINLGSSRTDLFYQKKTNRSTNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNG8</accession>
    <name>A0A367LNG8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_2735</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNG8"/>
    <dbReference type="STRING" id="1330021.A0A367LNG8"/>
    <dbReference type="OrthoDB" id="342264at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035361">
        <property type="term" value="C:Cul8-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990683">
        <property type="term" value="P:DNA double-strand break attachment to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18436">
        <property type="entry name" value="BRCT_BRC1_like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18437">
        <property type="entry name" value="BRCT_BRC1_like_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18438">
        <property type="entry name" value="BRCT_BRC1_like_rpt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17743">
        <property type="entry name" value="BRCT_BRC1_like_rpt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18439">
        <property type="entry name" value="BRCT_BRC1_like_rpt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000048">
        <property type="entry name" value="DNA repair protein Rtt107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053036">
        <property type="entry name" value="CellCycle_DNARepair_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47667">
        <property type="entry name" value="REGULATOR OF TY1 TRANSPOSITION PROTEIN 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47667:SF1">
        <property type="entry name" value="REGULATOR OF TY1 TRANSPOSITION PROTEIN 107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16770">
        <property type="entry name" value="RTT107_BRCT_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="99"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="335"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="475"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI15960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="883" mass="98542" checksum="772786AA860C604E" modified="2018-11-07" version="1">MKDAIFGECSVAFVPSNQLAPKLIAELSRIVEENGASVREPKRDGSIPVEKVTHIISNNIDFPQYVESQAFMVPVVSTQWITASISKRKAAQVRPFSPDPRMIFAEVVVTCAGLPVMDKETIIGATMALGGQENKDVCRMTTHICALSADDPKVALALQKGLKCKVVLPHWFDDCFKLGKRIDEGPYLLPDPEILSKSAHDEVDIPVNTNLTDAVSANPEWVPLPPDSDGVRPPVTVFRDRRVFLSDDLNMTVRFKRVIKDIIANGGGKVVDDVDKCQMFIGQYRDGSQYVQASRSCKEVGSLSWLFYLIVRNQWRNPLHRLLHYPIPRDGIPGFKGLRITVSNYGGEARIYLENLIKASGAEFTKGMKPENTHLITARNTSDKCKAAPEWGIALVNHLWLEESYAKCEKKQINLPKYNHFPPRTNLGEIIGQTFLDETCLRNLYYPGGEEAMSPRAKRKRKLLEAAEENAYHKGPAEGLAIVEPDVDVMPDDDDDDDDDDDDDDDNDGTDRRKRKKKAPKSRASAVETPLRPRQANDQGKDATDITTTPSALSTGGRSAKAKARDRLQDIAPDIALYEKEKRRQGKASGAPWGGKRAADLAEREQGEKTASKALRKDESDDEAGRPAKKSRPSLPDVEMRIMVTAFNRWVGDSNKEDHDRRWPTDETLPGSQRKLRDLGIQIVQEGQACDYLAAPKVVRTVKFLCTLSRGVTVLSTDFIEAVLESGEVPSPVDYLLEDEAAEKKYRIKLSRSEARAKSNKGKLLLGVPIYCTEKVRNGPDSYRAIAEANGAIFKLYRARSGTTIKPTTAEEDGDALPEPVYLLSNASVEERQLWPRFKAMAEKGNMEARVVVPDWLLDVAMAQQVRFNEEFLVEKFHEDELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNM2</accession>
    <name>A0A367LNM2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_3026</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNM2"/>
    <dbReference type="OrthoDB" id="5282002at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027974">
        <property type="entry name" value="DUF4470"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14737">
        <property type="entry name" value="DUF4470"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="6"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI15981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="594" mass="68794" checksum="5AB3B6F331F883DC" modified="2018-11-07" version="1">MASPPEFVCTNWTAENSECKKQGRYTCKNCLLVAYCGPECQKAHWPQHKMDCRMALGRDDWQPSWVDEKRRPAFYDKENQERRTVISKYIWGNSPAIDIVKLKDNEGEHYDRDLRLLFAASGDLRHVFKTVADLPASFQRKVEITTNDFDIDATARNIILLLIAFVVEDIEEATDCMIHTWYSASLRKSHMEILQTRIRPLIKRVCSRIKTKTDKTIVAKTWIIRGRTFRVVMPKQGWKSALDYFKLRDGLSVEGARQIRLNVTMAETRADWKERIYCCKVPRHRVCLHRFFEDGIVAPFGLPRHDFTEPNPTMYNEFNFWPTLSESDPAAGWDSKDVAETSSGPASADMYGKLYYHVRSVIQSFIRRSAEGQVSIRLLHYDLVELIDRLPGETFSRIDARLPFPNKMMILLLLRYGSRKKKLTGIKVSNVADNLWLGIHHVLIHLIPMLQSPDNNPHATLITFFMNAVDETISDQEKVRKLDRASRERLQAYLLGSFLDKAPHVELIKAAMAMDIVVRYDDTFERYANKANFCQAAALIGAAIKDRPTIVEKWPYRLKLRPGQPKAQEEFDRLLGSWAIGKERYVEWKKVDML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPH7</accession>
    <name>A0A367LPH7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_1850</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPH7"/>
    <dbReference type="STRING" id="1330021.A0A367LPH7"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04206">
        <property type="entry name" value="CuRO_1_LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04205">
        <property type="entry name" value="CuRO_2_LCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF2">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="296"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="466"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="491"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="564"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="12">
        <location>
            <begin position="50"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="520"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="373"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="520"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI16287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1140" mass="126483" checksum="E250E344A64B5857" modified="2018-11-07" version="1" fragment="single">RKKKKSLSSWLAGDHRQFLVDRHGTWELDPVPCMDAGDPLNWPTTKKAVNLALVSFHAMMFSFMPAAIQCAFVDIAHDLDVSVQQASYLTSLFIGILGLSALFWAPLAHTFGRRPVYLVSLAGSLVGSVGCGLSARSYGAVAFCRALTAFFVSPTGALGTAVVSDLFFHRHRGCCLGVWTVMTTVGIPLAPVVFGFVALRVGYRWIYWILAIANFVQLVLHYLFGSETRYEPATKTTATTTTTTTTTTSFPSSSASPSASASSRHHLLKKLRRIDPKPIGWYDFVRPLTFVTRWRVAIAAASFSVIFLWGSIMVNLEMPQIFPAKFGLNPQDVGLQNMAVIVGTLLGELIGGYASDRWMALGRRRLRRREKDEVVEEVEEEEEEDKGQNKDKTNLPPEFRLWLSYVGYALTIVGCTVFFLQLDKASNRWNVTPLVGVALAAVGNQMVTTVLMTYTVDCYPADATAVGAFLNFVRLTFGFVGPFWFPQMIENLGFVRCIAVPVVMISVVSVLPTMLLQSKGSHHHHHHHHHHHHHHHRLTTMTDAPNAHPRRRPTRRILAQASKWTALALLALATVLALPLLAYTRRQRLPVVAPPTHDGQKQLAVRLHPENHVRREPTVLTYNWTVTRGLRWPDGVEKMVYLVNGLFPGPTIEARSGDRIVVDVVNGLASEDVAIHWHGLRMRGHNHMDGAVGFTQCGTKPGQSFVYDFTVGRQEHGTFWWHGHDQMQRGDGLFGGLVVHRPGAVVEDEDEALLLVGDWFHRSQTDMLRWYADHGSLGNEPVPDSLLVNGRGRFDCSHAVPARPVVCSRAASLDPIFARRSSKTRVRIVNTGSVAGFSLALDGAQLQIVAVDGGCAVRDRPGRSVGVLYPGERVDVVLRWMDERDARLNIYLDDENFSGFPNEALTQNQSFRALSSPPDSLLVVEPTPLASGDHHRNLLDVKAASSSGRMPSRAKWTILFYFKTQRLSRFGNRPMGFVNHTTWTAQTPPLLSLNRSLWDDHQMVPFVPSTYPRTTVDIVINNLDDGSHPVHLHGNAFHLLSSYRADGRDGWGSYNPFASDHPPGPVNLENPVLKDTVAVPRRGHVVLRLAAENPGLWMLHCHMLVHLGTGMVAGLHVGDEFNHKGVKPWAARMCGRPSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQ53</accession>
    <name>A0A367LQ53_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MaoC-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2926</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQ53"/>
    <dbReference type="STRING" id="1330021.A0A367LQ53"/>
    <dbReference type="OrthoDB" id="3257538at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052741">
        <property type="entry name" value="Mitochondrial_HTD2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28152">
        <property type="entry name" value="HYDROXYACYL-THIOESTER DEHYDRATASE TYPE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28152:SF1">
        <property type="entry name" value="HYDROXYACYL-THIOESTER DEHYDRATASE TYPE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="370"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="423" mass="47209" checksum="89FD5C46D9A68FB9" modified="2018-11-07" version="1">MGWGLPNHPIKKNIMRPLAWNKMAATIAAKPQATADRGSALHKTEMFDYLTPMPSHLLNTLLQDLDGQAEIEDENNRNRSTMKMKSPPRTLPQGHHLVYFPLQAPASKLAADGADATHLSIAVANSSSEEEDGKGSGKQQGPRRRLWAGGEISFSRGWQSRLKLDCRPWYCREEVSGKKSRGGIVHVWRRYRLGHEGCGRPGGEEKEEEEERWDIVEKRVLAFRSEGEGKPIFERGMYCLSFPFFLLLLITSTQLNSTQLISSHLITAKPASSLRHRLVAPTKAHLFQFSALSYNAHLIHYDVEYARAVDRHPSLLVHGPLALAIMIRHLVAQEKTPLRRIVYRNLAPLYVDNPIFFCLGASPPAPAPAPSSSSSSSSSSSSFCSSEEDGRLPRWRRHVWLEGPDGYVAVKADAEFDTDALSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQE3</accession>
    <name>A0A367LQE3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L249_2219</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the UPL family. TOM1/PTR1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="4"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LQE3"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000004">
        <property type="entry name" value="E3 ubiquitin-protein ligase HUWE1, variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase NEDD4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1750.10:FF:000003">
        <property type="entry name" value="E3 ubiquitin-protein ligase UPL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010309">
        <property type="entry name" value="E3_Ub_ligase_DUF908"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010314">
        <property type="entry name" value="E3_Ub_ligase_DUF913"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050409">
        <property type="entry name" value="E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025527">
        <property type="entry name" value="HUWE1/Rev1_UBM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254:SF67">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HUWE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11254">
        <property type="entry name" value="HECT DOMAIN UBIQUITIN-PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06012">
        <property type="entry name" value="DUF908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06025">
        <property type="entry name" value="DUF913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14377">
        <property type="entry name" value="UBM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="7 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="14">
        <location>
            <begin position="3699"/>
            <end position="4035"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="289"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="729"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1166"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1523"/>
            <end position="1616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1967"/>
            <end position="2016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="2044"/>
            <end position="2077"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="2319"/>
            <end position="2567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="2649"/>
            <end position="2685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="2730"/>
            <end position="2769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="2816"/>
            <end position="2860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="2877"/>
            <end position="2924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="2999"/>
            <end position="3024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="3089"/>
            <end position="3108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="3191"/>
            <end position="3224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="3327"/>
            <end position="3404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="3584"/>
            <end position="3605"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="1619"/>
            <end position="1646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="307"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="734"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1202"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1554"/>
            <end position="1564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1584"/>
            <end position="1594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1976"/>
            <end position="1994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1995"/>
            <end position="2015"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="2061"/>
            <end position="2076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="2347"/>
            <end position="2356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="2371"/>
            <end position="2417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="2435"/>
            <end position="2510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="2553"/>
            <end position="2567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="2736"/>
            <end position="2756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="2757"/>
            <end position="2769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="2902"/>
            <end position="2924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="2999"/>
            <end position="3014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="3327"/>
            <end position="3337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="3340"/>
            <end position="3366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="3375"/>
            <end position="3392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="3584"/>
            <end position="3595"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="11">
        <location>
            <position position="4002"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCI16673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="4035" mass="449786" checksum="0F6DE09762C81C2F" modified="2018-11-07" version="1">MAKITKTMQPRHKETLVSFPYHFCHWTESATTLALPLLPAYLATFPSRWPFGRGDLYHWIPLLNRFDSILDQFCKTYRLHGGPQHCDFRCDLLLNTEKDSIFGKEKSWEGRELVDLGFSPEGDQQLVEAVLRFTRMLLEHCGNRSIYASSAHLNDLLNSSSLSVIIAALEVGSELAQRYQASVKRIGSSSRQISAALLANHYNIDLDRVQQIALPFSKTPIVSLCDYASSTTPSSVKGKEKAQTSVPRTTTSMHANDLVAVAAGDEKFWADWADVRVFYYPQDSLANTDTPADVGRSTLPSTPTPLRRSSTMSNQQHTPRPRNAAVDDSSPIGPRTPAVAEEHNFLGQRSLDIPRSAVLTTPIYELAQRCPDDMPPAAKYEVFQRLRVAKALTGSVEARQQILAARLLAITNLSYIHAESNFVDKVLRQDIDETRRYQLVYQLAELIHPSSDGKADVPLWLQSIALALLEAISGFHARCQDVLSALNANVNHGILLYVIRKAVAGMAEDYAADANEQVTAADEWRNNLFSLTLHLSMTTRVGSEMASAGLMDILAEILGLRSKISQRHHAMVLAFLDGLIWTYQTAFTAFINASGLDTVARLLVDTVAEARRSLGSSKCIKADQQSSAVDYEIPYYQQQTLKWLLKFIHHVMSNAYTYNGNTDRLVRNLAEKSDLLRSLREIMEDKKSFGSVVWTNSVTILSDFINNDPTSFAAISESGMIKTYLEAITGRPIPENHTDQRQKDNRSEEREEDESPDSPAIASILEDDGRPHPPPAEVLRQSRPQPLAKGILASHDAISVVPQVLNSISLNNTGMKMVVASRAFESYLEIFESPAHVKCLDADNDLAHTVGGSFDELARHHPPLRTSISNAVIDMVARVRFLGLEKARACGWGARLFVTGANGELLSITERGTTEDASKLSPQVREHAILGDADVEMSDVVSADEPRAGRSEEDAFYEAAHAMETSTDYITTYIHSLASFLTSYLSNSLLKTNFIKKGGIELLLDICESPSLPANFGDTITSRALQQVVSQLVEHSPIRALPSVLRRAQAAIDVLKPLADKTETLPPYFAPFLVPDLAVIRNGSEAPPPVLEGTRLVKALLNAQTFIKIISECFFTSRNNALNFYPVNVYDYYLNLVRSVGPLLRGVLAEEAGQMSVIPQHWSVRRHPPPYNGNRDADLQTDDTPVPEVLKSTATGGPATMRPTQQEQASPRFQNYETLRVLLHPMIPTLFPLFQSLGKSLLPRRSEPNNPEPFTRSRHLEIAKALADSILSHLAPSVAMAEPTSKDFHYWIIMLHTIHEMLIDHPSSRQSDRSHLLHIVMPVLLAFKERGGLDVLNSMLRVFARAVRQGGDGASDESSKSKVAAFGLKKVLDLYHYLVDGKYVSDTANFFNLQPRHLDRASPSLVCQQIVVQFRAAVLSAMMELWDSNFLDRIPDATVKRLLGILKIIASGDHELQNVNMHLVPFNLFKHKDARFDWQPLRGVVGEIISAGFDEGLVHEAVYRGSGNGSFATDYCTAHKDGLAGLRNPIPPEDSDTSPLRDAGTPANDREPSQNDIEPSSGSAVSDVDRMSLDVLPPDLNADGLRDMIERPDQMDETQDSASGPAASAPTVGTADGANQDAVAQLVAAKEELDNLRTKLKQNLIAQCLDIIRTHPETAMDVNELIGVMALRRQNYEAYKEVGTTLTLALSSLGFDEDEQKRNGKCIAAYAHLLALFVQDSHFLEANMEILREKVDEYVDLLKLPMSSSSEDLPPWIPFILLILELFLCHDARLVAAQWKAPKTIDEPVTAPVIQTGTSLVGEADRMKILDSLLDLLPRIGKEEMLATAALRVVVILTRSRQAAKLVGEKRNLQRLFLMAKQLSGSGSERLKQTRLTAYIITILRHVIEDDEIVKQIMRAEIQADFSNIQRNQRGPVDVSTYLRAMAPVALRNPDLFVEVTNELVEFTRWQPSPAEGNRLQGLALKSASKEGSDNAKPSNDEASSSQEIKQSTETADKEMCDAPKASQHDSKRPVVENPDGVIHFLLCELVNYREVDDKDPATLGTECKTEGESSTANRDSSVRDKPASEEKDRKQAKPVFKAVEHPIFVYRCFLLNCLAELLQSYVRTKVEFINFKRSAPPPTTQTPIKPRSSILNYLIYDLLCQGNLHGTTDSIASKKKVATSTLTQRVLVALVSKTNEKPVERNRDKFAYDDEPDLLFVRKFVLDTVLKAYEKAPLADEPLETRYTRMQCLAELMNQMIGEKDKDQNSGARAADNAQLQNRSQAQLRRLMYEKGYIEKLTSSIAEVGLNYPGVKRAIKYILRVLRALTGTAKELSLSPLSSSLPTDAAADNSEDEFASTSSLSDVDDDREETPDLYRNSALGMLEPRADDDESGEEDEDDEDMYGDEYDDEEMDYGDDDISEDGEDNISEDDELSGMGEIEGLHGDPGVVEVMEEDDDDTADDDEDDDEEMDSADMEDLEDRVQIVDEEGNPLEDDGESAWESESDVEEVEDQEADDIDYEGEGQDEMEAHLHDIGPGGLLDDMARVIMGQDDGYEPELDVDNEHFLEDAHDDGEEDDEEDDMEDEEYIYDDDYPLDEQPPPIPNTMSWDNFDPEDPQIQLMLLDAGHRRSVLARMDNRSPFPPRFMAGSNRDHLDFRSYFSRGHRSTGAQANADDGVNPLLRPQQATPEASPRPGHSHSVGLRLPEGVFGGRNGVDGPMDLLGELMEFLPIMGRGNTGQAFHFHITGPGGSRETREVGATRWSRNEQRRDGTSQEPHQAVSFTPESTLDRYQEEARMMFRDLITAASKLHNIIVAKLTPAAIELEKKIRAKDAEEQKRADEERKKREEEERKAREAKAAEEKAVKEQKEAEAREAAERAAAAAAAAAAAVASSTTEVTTSDGHGDAGGAMEGVEPADTSGTNRSGVQSNAAADSGSQRRVMTTLRGEEVDVTELGIDPDYLAALPEEFREEVIAQTVSERRLQAREEAATGESTEVFQEFLDALPEELRLEIAQQERQDERRREREEARRQAAHAGGSNAVAAEMDPASILLTFPPELREQALIDQGEDLMDQLPPEMAAQARALAQQHAPMPQHRGIRSIVAQGRSPPGGGRAEARNVAGGQGEAKAQRRTVIQMLDKSGIATLLRLMFIAQQGSIRSYLFSVFADVCENRQNRLEVVSSILQILQEGSVDMNAVERSFGQLSLRARRHKEKEAEQKTPQNLKRTLAGPAVSGGSAAQTNSETSPLLIVQQCLDLLVDLSSRSHHIAWLFLTEHEIVGTTLKRALSRKGRVKDPKAHKYAINSLLTLLDRDLVTESSLAMTHLADLLNRVTLPLQNLERRRRETMEEAKDAKPATSDQPSTTGAGEASETTPGQGQTSSDQHNVDAATETAKDETEVKKRKEEEATQKRSRQTQPPVIPPQNLTLVVRIFVARECNSKTFQNTISTIKNLSVIPGAKAAFGQELVRQARLLSENIVSDLDDLLPHIDQATSRTEIQGVALAKFSPGASEQNKLLRVLTALDHLFDGKKKARDEEDAATKDREKQYLVTSLYHNSTFLAMWEKLSACLRAIRQRENMLNVATILLPLIESLMVVCKNTTNDDQPTTSQTTMRDMVLSSPPPESRTASLFYSFTEDHRRILNELVRHNPKLMSGTFALLVKNPKVLDFDNKRNYFNRSVHSRSGQHNGRPSYPTLQLSVRRDHVFHDSFKSLYFKSGDEMKFGKLNIRFHGEEGVDAGGVTREWFQVLARQMFDPNYALFIPVSSDQTTFHPNKLSGINDEHLMFFKFIGRVIGKALYEGRLLDCFFSRAVYKRILGKSVSVKDMESFDPDYYKSLCWMLDNEITDIITETFSVENDEFGVTTVVDLVPNGREILVSEENKHEYVRLVVEHKLLASVKDQMEHFLKGFHEIIPAKLISIFNEQELELLISGLPDIDIDDWKSNTEYQNYTPSSQQIQWFWRAVRSFDKEERAKLLQFVTGTSKVPLNGFKELEGMNGVNRFNIHRDYGNKDRLPSSHTCFNQLDLPEYDTYDMLRSQLHKAITQGSEYFGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQF7</accession>
    <name>A0A367LQF7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">NADH-ubiquinone oxidoreductase B12 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_2965</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB3 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQF7"/>
    <dbReference type="STRING" id="1330021.A0A367LQF7"/>
    <dbReference type="OrthoDB" id="521512at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012576">
        <property type="entry name" value="NDUFB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15082:SF2">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15082">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE B12 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08122">
        <property type="entry name" value="NDUF_B12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI16676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="94" mass="10805" checksum="FBFE535CF2E18A34" modified="2018-11-07" version="1">MVILRAARHPKPNITGFDIRALRAATGTPPNDPWQRAEAWRYTGTFSRWNRYKNCTPGLGIATVAFAAYCLYEHLFMEDEHHHSESHAEQGQQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQM3</accession>
    <name>A0A367LQM3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_3015</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat MET30/SCONB/SCON-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQM3"/>
    <dbReference type="STRING" id="1330021.A0A367LQM3"/>
    <dbReference type="OrthoDB" id="190105at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd22147">
        <property type="entry name" value="F-box_SpPof1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847:SF741">
        <property type="entry name" value="E3 UBIQUITIN LIGASE COMPLEX SCF SUBUNIT SCONB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22847">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="6">
        <location>
            <begin position="466"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="716"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="786"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="832"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="872"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="914"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="134"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="248"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="324"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="571"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="158"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="366"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI16755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1058" mass="116685" checksum="3CEC031E76DD26D0" modified="2018-11-07" version="1">MTPSPTPARPARQSRRPRSAQPAPPANTAAEAPSHGFQVQVSECFETRTVTTTTCLTRKFPPFFVHDPTPLQSLDSKEYPLATKPTPRELLEFPYVPKDAVDVRHGHESGSVKPTNRSARVTMTPVALKLEPVARQTHDRPSRCPRVHTRRVRASVAGSPTPSNTTMSQPLTSLPRPWREPCHSIVTPDKLRRPIAPEGSTAIRSEDGVGLGPTGPQPARGADSASLGKSREAELAFLSAYHSAQALQLSAQHSKRPDSPRNSSTDSAQSSSQLSLCNAASPSGSDSFTVFSSNVATPPITDADAAPFGDADVDEALQQSVRGLHPRPAVGDVATQDASLPSPRLSPTLAASQPASTDQDDDVSAGVSTSLTDPASSWTAETQLKQEGLVEDRDEFKELEDAWLAKHLHAADAPSSPVTMNMQSMLEAFDAMRTEMKTFMMYQFLRRCPRPTLRVIADTVNPTLKCDFLLQLPPELAYSVLSHLDCRDLCRAAQVSKHWRNMVDRNETGWKELFDRDGFVLPPGELTKAVVQGWGWQDPVGVTEYEMNLSMQSRLTSSEFELTRNLRQSATTLPRLRSSKRKRGLNAYSASERSKRRAAAGQTREQHAGQQTEARQHKSEGPLSAANAAALAVPDPKMGLPSLRQLHLFKSLYRRHYMIRRNWTSDDVKPSHVAFAAHPRHVITCLQFDNDKIITGSDDTLIHIYDTKTGKLRKKLVGHEGGVWALQYEGNILVSGSTDRSVRVWDMERGLCQQVFYGHTSTVRCLQILMPTQTGRDAAGRPMMRPEKPLIITGSRDSQLRVWRLPEIGSRRYIQTHPPAQESDCPYFIRALMGHSHSVRAISAHGDTLVSGSYDCTVRVWRISTGDSLHILRGHTQKVYSVVLDHERNRCISGSMDSLVKIWDLGTGSCLHTLEGHSLLVGLLDLRDERLVSAAADSTLRIWEPETGRCRHTLMAHTGAITCFQHDGHKVISGSEKTVKMWDAHTGQCVRDLLTDLSGVWQVKFDGRRCVAAVQRDQLTYVEILDFGAIRDGQPPGELGKRVLLDGDGVEVVDDGAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQU5</accession>
    <name>A0A367LQU5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Electron transfer flavoprotein-ubiquinone oxidoreductase</fullName>
            <shortName evidence="19">ETF-QO</shortName>
            <ecNumber evidence="19">1.5.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">L249_2703</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 19">Accepts electrons from ETF and reduces ubiquinone.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18 19">
            <text>a ubiquinone + reduced [electron-transfer flavoprotein] = a ubiquinol + oxidized [electron-transfer flavoprotein] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24052"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="Rhea" id="RHEA-COMP:10685"/>
            <dbReference type="Rhea" id="RHEA-COMP:10686"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
            <dbReference type="ChEBI" id="CHEBI:58307"/>
            <dbReference type="EC" id="1.5.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 19">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="19">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="19">Binds 1 [4Fe-4S] cluster.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ETF-QO/FixC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.1" evidence="19"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQU5"/>
    <dbReference type="STRING" id="1330021.A0A367LQU5"/>
    <dbReference type="OrthoDB" id="437331at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000015">
        <property type="entry name" value="Electron transfer flavoprotein-ubiquinone oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040156">
        <property type="entry name" value="ETF-QO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049398">
        <property type="entry name" value="ETF-QO/FixC_UQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007859">
        <property type="entry name" value="ETF-QO/FixX_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10617:SF107">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN-UBIQUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21162">
        <property type="entry name" value="ETFQO_UQ-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05187">
        <property type="entry name" value="Fer4_ETF_QO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 19" id="KW-0249">Electron transport</keyword>
    <keyword evidence="9 19" id="KW-0274">FAD</keyword>
    <keyword evidence="6 19" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 19" id="KW-0408">Iron</keyword>
    <keyword evidence="14 19" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 19" id="KW-0813">Transport</keyword>
    <keyword evidence="15 19" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="20">
        <location>
            <begin position="586"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00052682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU366068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RCI16834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="626" mass="69125" checksum="4395A77D0BF522A9" modified="2018-11-07" version="1">MAAPSAVVTVSRCAAQRVPRTAVARCILLRSSQPSRRRRRPCAACPTITRRYFSEGMARRQRQTTEDDANRTVERESDQVDVCIVGGGPAGMSAAIRLKQLAGEAGRDDFRVLVLEKAGDVGAHILSGAVLQPSSVKELVPNWLDEDNASRFRYATPAGTDQMRFLTRTAAIPLPAPPQMGNHGNYIVSLNQFVKWLGEQAEEAGVEVYPGFAAAEVLYAPDGSVKGVATNDLGIARDGRPKDTYQPGMEFHARVTLFAEGCHGSLSKQVINKFDLRKDSQHQTYGIGLKEVWEVDPAKFESGRVVHAMGYPLPRDVYGGSFMYHFGDNLVSLGLVVSLDYRNPWLSPYQEFQKLKHHPLFRKVLEGGKCISYGARALVEGGFQSIPKVAFPGGALIGDSAGFVNVPKVKGTHNAMKSGMLAAEAAWTALSQSNDGTVFLYDYEDSLRNSSVWKELKEVRNMRPSFHTPLGIYGGLAYSGLEAFVLRGRAPWTLKHKEPDYAATQPADRYPKIEYAKPDGKISFDILTSVSRTGTNHEEDQPVHLQVADWEAHTEKAYPVFKGLENRFCPAGVYEYVEDPSRPYGVKFQINAQNCIHCKTCDIKAPQQDINWQVPQGGEGPKYYMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LR29</accession>
    <name>A0A367LR29_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LR29"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="87" mass="9902" checksum="D1F621AB1FB71C1A" modified="2018-11-07" version="1" fragment="single">MRGRLESRFTTDRRWLGAEKAEEDNQAKKPDSGDTYSKTKKEERKNLLARPPTYLSMHLDACRILPIGRGSQLKGQRATGLLDGDRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRC3</accession>
    <name>A0A367LRC3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7871 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRC3"/>
    <dbReference type="OrthoDB" id="4140664at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057193">
        <property type="entry name" value="DUF7871"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40620">
        <property type="entry name" value="RESISTANCE PROTEIN CRD2, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04318)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40620:SF1">
        <property type="entry name" value="RESISTANCE PROTEIN CRD2, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04318)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25277">
        <property type="entry name" value="DUF7871"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7871" evidence="1">
        <location>
            <begin position="4"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="110" mass="11190" checksum="17FD15A00077FFAB" modified="2018-11-07" version="1">MVSKSSTCCGKGGASECACAQQATCSCGKQSALHCTCAKAAEENTVQGPRCSCRARPAGECTCDRAATENMRPSGSTCDCGARPAGACTCEKARDGGYNPATETDFTTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRE2</accession>
    <name>A0A367LRE2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Coiled-coil domain-containing protein 16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_3054</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRE2"/>
    <dbReference type="STRING" id="1330021.A0A367LRE2"/>
    <dbReference type="OrthoDB" id="77607at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033260">
        <property type="term" value="P:nuclear DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040050">
        <property type="entry name" value="ZNF830-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13278">
        <property type="entry name" value="ZINC FINGER PROTEIN 830"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13278:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN 830"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="51"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="261"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="66"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="96"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="277"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI16920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="39400" checksum="95C576A752BED144" modified="2018-11-07" version="1">MADVRSLLRQQRTARRVQHPYAAYTDGGKLLCTLCRLQVKAESLWEKHLLSQGHRESLPRREDDSTTTTTTTTTMATTTLAQKRPLDEADDGDQGQESRVDEDTLRRKRSRLEAASPVESSVKNGGGSSEHVSLASPSLIRRTSTTPSQGVELQIPSRPATPSHRDTPSSSASGIAPPPPSRRRAGSNLTPTTTTTAQKVDEAEWAAFEADIAVAAAAPYDYEDAVISAPAMTAEESAAAKALDKQTDKLKVDIDLEEEREEAARAMEDEFQDMQELEERVKQLKDRREALRKRSDSHSQDHPAPEKMPSGPGRGKEMNHDTGAVNGTEEEKEEEEEEEDDDDDDDDWDGFRFRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRM1</accession>
    <name>A0A367LRM1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRM1"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI17096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="189" mass="21253" checksum="292A14B549ED2921" modified="2018-11-07" version="1">MKKWIIAPPPCHVAHQTGEDGGETLPGQEGCRRAFIAGVRLGQWLGFGFAMEHMGKEKGAMTWKAFYRQLIPHSVQSSPVFSRPGLGPVSLMAKIHPSIHTTWASGEMETEGREGRGGEGEIERLGYMSLDPFPRYSFNRGCKFQVLIVIPHLTIEHVAKRQRQSVYNLFAPFINIIVIFFFFLVATLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LSE3</accession>
    <name>A0A367LSE3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_2816</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LSE3"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI17162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="90" mass="10632" checksum="D36C770C6F720131" modified="2018-11-07" version="1" fragment="single">YSNSAKTRYKDIRTFSRKKGEFSAFLTNLKDKIRTNKATFRDKEDRIGFLFRSLEGKARKILETYLLTKTKDDSLSYEDFCGYVKDSVYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LSJ0</accession>
    <name>A0A367LSJ0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidylinositol 3-kinase VPS34</fullName>
            <ecNumber evidence="7">2.7.1.137</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_2875</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12709"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.137"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:12710"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.137" evidence="7"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LSJ0"/>
    <dbReference type="STRING" id="1330021.A0A367LSJ0"/>
    <dbReference type="OrthoDB" id="67688at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016303">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08397">
        <property type="entry name" value="C2_PI3K_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00870">
        <property type="entry name" value="PI3Ka_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00896">
        <property type="entry name" value="PI3Kc_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 3-kinase catalytic subunit type 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1010.10:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 3-kinase catalytic subunit type 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.70:FF:000009">
        <property type="entry name" value="Phosphatidylinositol 3-kinase VPS34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057756">
        <property type="entry name" value="PI3-kinase_type3/VPS34_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002420">
        <property type="entry name" value="PI3K-type_C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008290">
        <property type="entry name" value="PI3K_Vps34"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF7">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00792">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000587">
        <property type="entry name" value="PI3K_Vps34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00142">
        <property type="entry name" value="PI3K_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51547">
        <property type="entry name" value="C2_PI3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="C2 PI3K-type" evidence="11">
        <location>
            <begin position="18"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="PIK helical" evidence="10">
        <location>
            <begin position="364"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="9">
        <location>
            <begin position="631"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="158"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI17320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="915" mass="102939" checksum="498C2954634B2387" modified="2018-11-07" version="1">MTEYGRMDPFSFAGSKDVDHAVSIRIMNLDGEEPPVKHSTLLDRPDLRHVGSNTSPFSDLYVTVQVWAGSKPLTVPVQTAYKSFRSERKWNEWLELPITYKQLPVNARLAITIWDLSPTGGKHALDHEIPFGGTTLPMFDADNQVQKGRQKCLVHRHKHADGTDNSTTPALLAPRNTSGSRAGKAPHLDKNAEELDRMEKLFKKHEMGEIARVDWLDQMVFRSFEKRGLQAAKSSMKMLQRQRAVNGDGVQVDADADDGRSSPSAFLLNVELPRFDFPVVFADHEYEPPPISSLQPLSASQGSIAQRQPEVHFGPGINGLGESSDGLGTRLIKVYDPEVGQRDNPAEAKHRRLFRSSHRHGVLDKDLKPNAKVRDELNLIMSYSPTHVLSPEETDLVWKFRHHLTRDKRALTKFVKSVNWNDQSEAKQAIQNLGSWTEIDVDDALELLGPSFDNPAVRSYAVDRLRKADDAELLLYLLQLVQALKYEHISAESDHDGAHDSSLASFLIQRAAANFMLGNYLYWYLMVECDDHSPEQGLDNRNIYRKVAYEFMAQLVRQPDGAENRKTLLRQAELVAILSKIAAEVKVSNESIAKKVDRVKTFLADPKNELVTLEPPLAMPLDPSIKITGVAADQVTVFKSSLNPIKMTFKTTTGSAYPIIFKLGDDLRQDQLVIQIITLMDQLLRKENLDLKLSPYKILATSTTAGASQFVQSQSLSSIVGKFKTNPALAYLRHHNPDDRQPLGVRQETLDTYIKSCAGYCVITYILGVGDRHLDNLLLAPDGHFFHADFGFILGRDPKPFAPVMKLSKEMVECMGGVHSEHYQRFRQYCFLAYTALRKSCNLILNLFSLMIHANIPDIRLEPDKAVIKVRERFHLELSEEEAIVYFGNVIDGTLTAFAPVVIDKLHEWAQALRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZ46</accession>
    <name>A0A367KZ46_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Conidiation protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000028">
        <property type="protein sequence ID" value="RCI07436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZ46"/>
    <dbReference type="OrthoDB" id="5419162at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018824">
        <property type="entry name" value="Conidiation-specific_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052670">
        <property type="entry name" value="UPF0654_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36576">
        <property type="entry name" value="UPF0654 PROTEIN C11D3.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36576:SF1">
        <property type="entry name" value="UPF0654 PROTEIN C11D3.01C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10346">
        <property type="entry name" value="Con-6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI07436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="82" mass="8626" checksum="058A76087718F1E4" modified="2018-11-07" version="1">MPTEAQIAGGHKATLKNPNVSDEAKQHSREVLDNEFNGGNVPKTGDGEKNAGNVAGGLKATLKNPNVSEEAKQSAQERLEAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZ53</accession>
    <name>A0A367KZ53_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000028">
        <property type="protein sequence ID" value="RCI07448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZ53"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016794908" evidence="1">
        <location>
            <begin position="19"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI07448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="84" mass="9318" checksum="18827922E3904073" modified="2018-11-07" version="1">MKLVLPIFALVGTVLCTARYYKGQPTWSGRLFASVPQRGGTCWHPSGCVTSARACSRWCRRRGVSHQRRGGCEDGRVVCCCKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0D1</accession>
    <name>A0A367L0D1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosome biogenesis protein NSA2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ribosome biogenesis protein nsa2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L249_5855</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000023">
        <property type="protein sequence ID" value="RCI07888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0D1"/>
    <dbReference type="STRING" id="1330021.A0A367L0D1"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016274">
        <property type="term" value="F:protein-arginine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11381">
        <property type="entry name" value="NSA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000001">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000050">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.310:FF:000001">
        <property type="entry name" value="NSA2, ribosome biogenesis homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039411">
        <property type="entry name" value="NSA2_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF53">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06325">
        <property type="entry name" value="PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="9 13" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="15">
        <location>
            <begin position="647"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="243"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="294"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="294"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCI07888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="826" mass="92786" checksum="5EC049C1D6F9FD6F" modified="2018-11-07" version="1">MGKLRNLRLGNLGDDAELGYPENGEAKLGFRLTFPTTAPLLLDLDSHRFRLGPQHGRSTDKQPVIDMRRPLHRKVPTSEDAGAIQAEYIAGYNARHSEREPHLVSLLHQCPGWAASTGSNLLTESAMGVGGGFGWLFLKANGLTSLPVGLGALLGCGGGGRGIGTLIMGAGGLKFARCWIGSGRWRSRAGLRSWSRGRRTGPGSKAEKLGGLEVGARISVMPSAEWPQNEYMERWRKLHGRRLDHEERTRKREAREGHKASKDAQNLRGLRAKLHQKKRHNEKIQMKKAIKAHEERNVKTASEKEPSTPMPSYLLDRNNPSKAKALSSAIKNKRAEKAARFSVPLPKVRGISEEEMFKVVKTGKKVQKKAWKRMVTKPTFVGPDFTRRNPKYERFIRPMGLRYKKANVTHPELGVTVQLPIISVKKNPQNPLYTQLGVLTKGTVIEVNVSELGLVTAGGKVVWGRYAQVTNNPENEGCINSSSGEKMEVEMAEEKMKALAHSEQHYFKSYDHHGIHEEMLKDEVRTRSYMNSIVQNKHLFKDKIVLDVGCGTAILSMFAVKAGAKHVIGVDMSSIVFKAREIVKANGMADKITLIQGKMEEVELPFPKVDIIISEWMGYFLLYESMLDTVLYARDAYLNKDGLIFPDKATIFFAGIEDGEYKEEKIGFWDNVYGFDYTPLKETALSEPLVDTVELKTVVTDPTSVLTLDLYTCTTADLNFTAPFRLTTKRADFVHALVAWFDIEFSACHKPIRFSTGPHAKYTHWKQTVFYFKDVLTVQRDEDIQCTLRVRPNAKNRRDLDIDIEYELETGDVTRSASGTCEYRMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L168</accession>
    <name>A0A367L168_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_7859</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000022">
        <property type="protein sequence ID" value="RCI07962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L168"/>
    <dbReference type="STRING" id="1330021.A0A367L168"/>
    <dbReference type="OrthoDB" id="2746at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039796">
        <property type="entry name" value="MIP18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI07962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="203" mass="22282" checksum="DE2C733379BED860" modified="2018-11-07" version="1">MALENANPTVLSASQLPTRHKAPAPRRGPDTRYDDLVFGAPPYLCRPWSRRSPVWPPSAAAHDDTCAAEPIDEQEVYDLISTISDPEHPVSLGQLSVINLSDISISPSPALGLPSPNTIVRVCVEITPTITHCSLATIIGLAVRVRLEQSLPPNYRVQVRCKENSHSQDEQVNKQLHDKERVAAALENDNLRGVLDKMLETCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1C7</accession>
    <name>A0A367L1C7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">choline-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="9">2.7.7.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">CTP:phosphocholine cytidylyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Phosphorylcholine transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_6328</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.15" evidence="9"/>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1C7"/>
    <dbReference type="STRING" id="1330021.A0A367L1C7"/>
    <dbReference type="OrthoDB" id="17102at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004105">
        <property type="term" value="F:choline-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000147">
        <property type="entry name" value="Cholinephosphate cytidylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045049">
        <property type="entry name" value="Pcy1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739:SF13">
        <property type="entry name" value="CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739">
        <property type="entry name" value="CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="13">
        <location>
            <begin position="163"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="352"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="401"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="353"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00080967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI08225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="438" mass="48072" checksum="73C010432B970CDF" modified="2018-11-07" version="1">MSSSSFDAHQGGKRKRAAAASIAAAADVGALQTSSRDASGEEGDTTAPESVRHHRRNSNGTGPNPKRQRANPDRDIALDPGEPSDTTEASVDIAERVGRKSRKVVPKNDDADADADADADDDADDDDKLEAIPPPPIGKLTHPAGGFKTNPPPVGRPVRVYADGVFDLHMRQLEQAKKAFPDTTLVVGVTGDKETHMRKGLTVLSAQERAETLRHCKWVDEVIEDCPWIVTPEFLEAHRLDYVAHDDLPYGADEGDDIYQPIKAAGKFLVTQRTEGVSTTGIITRIVRDYEKYLTRQFKRGTPRQELNVSWIKKNELDLKRHVQDLRDNIITNWTTTGQELSRELKHFWPASRPQSPARFSSSCGDATRSPISSTPGPGNSKDFVTGYALGLVGGVRSWMTKNRRTVVDSQQASEDESDEAEERKKSPPQLVLPTPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1W5</accession>
    <name>A0A367L1W5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AHC1-like C2H2 zinc-finger domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_8848</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1W5"/>
    <dbReference type="STRING" id="1330021.A0A367L1W5"/>
    <dbReference type="OrthoDB" id="5355528at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058706">
        <property type="entry name" value="zf-C2H2_AHC1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25909">
        <property type="entry name" value="zf-C2H2_AHC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AHC1-like C2H2 zinc-finger" evidence="2">
        <location>
            <begin position="225"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI08433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="570" mass="61260" checksum="3FD00A54E7F54869" modified="2018-11-07" version="1">MAESRAMFAEVHLGASLPTSSLKRYRDGPDELRVSSKRPKLVAHRHNSSPRHVLAAAAHADDVRDVIRHQFGLEVLLKHNELRLINQELAKCQVALEQLRRCHLVPYPQNCPTPAQMLDISSGTGPALAGPKPGEPTPRWAPPFGVVDGPYARHYAKWLIPHVVFDGPGSEPKPAPRPRAHAAEGRATRKSFAEPAKARPARGIPGPKLQALSSGYNPPKDRGGPCILKRADGTTVKLVCLDCKRENFSSTQGFINHCRIAHRRDFKSHGEAAAQSGHPIGMAHVAPPVADEKPAPAQRRSNLVHPLAQQDMTEQQAYAALRARINDSLKLYHAGKLPGVLDIPSGPPCSIRTPNAASQTPHLSRLMETRNFAGNLGDIVADAKTNLSPENLPSADDSDDGGLELVAAPPPVRTRVAMRVPARTVKSPVPRPTSSKGRLPLVTSASGLGLSKNSPAIILSDEDTEDMEESNLSPNTVISNVAPSLVSDDGDYDDTDEGSSVCGASDHLDGAAMSDVAEISLDEDHEPRALRRGSGGVTAKMKLHKDEAKHITIMSSVRGNAKGRRPPRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1Y7</accession>
    <name>A0A367L1Y7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_8976</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1Y7"/>
    <dbReference type="OrthoDB" id="44789at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006878">
        <property type="term" value="P:intracellular copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04591">
        <property type="entry name" value="CBS_pair_voltage-gated_CLC_euk_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000011">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1280.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF9">
        <property type="entry name" value="ANION_PROTON EXCHANGE TRANSPORTER GEF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7 9" id="KW-0868">Chloride</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="283"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="524"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="608"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="702"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="797"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="817"/>
            <end position="828"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI08417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="835" mass="91618" checksum="83B1109160E55467" modified="2018-11-07" version="1">MSQPPTSFGRHRRSSISSRLRYGAEADDGGEAGDGGGGGGGAFSEESGAGHVPSIDEAISEIKRYEDFSTIDWVQDAAREQSRRKSRRKRAAGLYVRGRSGWRYRLWASYDAAQGWIVVTIIGVAIGLNAAFLNIITEWLSDIKLGYCSTAFYLNQSFCCWGEETACSHWHRWTGFEPLNYLLYITFATLFAFVSAILVKSFAPYAAGSGISEIKCIIAGFVMKGFLGLRTLLIKSVCLPLAIASGLSVGKEGPSVHYAVCTGNVVSRLFTKYRRNASKTREILSACAAAGVAVAFGSPIGGVLFSLEEMSNYFPLKTMWRSYFCALVATAVLAAMNPFRTGQLVMFQVSYDRDWHFFEVLFYVLIGIFGGLYGALVIKWNLRAQAFRKKYLTKYAVLEATLLAAATAVIAYPNAILRIDMTESMEQLFLECEGAEDHHGLCERDRRARNVASLALATILRVFLVIISYGCKVPAGIFVPSMAIGASFGRTVGIIVQALHEANPTGIFFSACKPDEPCITPGTYAFLGAAAALSGIMHITVSVVVIMFELTGALTYILPTMIVVGVTKAVSDWFGKGGIADRMIWFSGFPYLDNKEDHNFGVPVSQVMRNSVVSLPVQGLSVAQVEQLLSDDKYQGFPVIEDNKSKMLAGYIGRPELRYGIDRIRRERAVEDANVGCVFAPPSGLSRQRGTTDAPLDLSGYVDTTPVRVHPRLPLETVMELFRKIGPRVILIEYHGKLAGLVTVKDCLKYQFKVEASENLKDDPRILESQAQLWAVLRQVGRWVSDRIWSVSGGSVRLGGRPDQASSDWSRGGSILDGDEESADEGLELEMRRQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2D7</accession>
    <name>A0A367L2D7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Transaldolase</fullName>
            <ecNumber evidence="4 10">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_4697</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transaldolase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="4 10"/>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2D7"/>
    <dbReference type="STRING" id="1330021.A0A367L2D7"/>
    <dbReference type="OrthoDB" id="2015515at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00957">
        <property type="entry name" value="Transaldolase_TalAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000088">
        <property type="entry name" value="Transaldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004730">
        <property type="entry name" value="Transaldolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00874">
        <property type="entry name" value="talAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683:SF18">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01054">
        <property type="entry name" value="TRANSALDOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00958">
        <property type="entry name" value="TRANSALDOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0704">Schiff base</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI08586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="331" mass="36300" checksum="E9B9EF457C481F3B" modified="2018-11-07" version="1">MLSDASSLWSIAIGKYKPQDATTNPSLILAASKKAEYAKLMDVAIAYGKSKGGSLDSQVDHALDRLLVEFGTEILKIIPGKVSTEVDARFSFDTKASVGKALHIIDVSPGALSVSRPLLTKLRGQLYKEQGVSKDRVLIKIASTWEGIKAAEILQRDHGVNCNLTLMFSLVQAIAAAEAQAFLISPFVGRILDWFKASTKKDYSKEDDPGVSSVKKIFDYYKKYGYKTIVMGASFRNTGEITELAGCDYLTISPNLLEDLMNSSEAVPKKLDAAVAAKSDVERRSYIEEESLFRFDFNEDQMAVEKLREGISKFAADAVTLKDILKAKLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2F8</accession>
    <name>A0A367L2F8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_4694</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2F8"/>
    <dbReference type="STRING" id="1330021.A0A367L2F8"/>
    <dbReference type="OrthoDB" id="66620at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052215">
        <property type="entry name" value="Plant_ABCG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48042">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48042:SF11">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="401"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="444"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="477"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="508"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="13"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI08587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="628" mass="69618" checksum="B1B2FD70DC4F3676" modified="2018-11-07" version="1">MDPEQLPVAEGHMRNTTVRNMAWHGVTVTVQDRETKRAKTIVDNAEAIVEAGECLGLMGPSGCGKTTLLRALARRRTNASVTAAARVLVNGRELPLSEFRQMTSFVEERDTVMGSLTVFETLAFSSKLSAARQAAPPPPSSPSGDKHQHLLRIHGLIDAFGLSSQTNALIGTPARKGLSDGQKRRVSIASQLITGPKILFLDEPTSGLDSVASFEVMHHLRKLAKRHNLIVICSIHQPSSSTFHLLDKVMLLSEGKTHYFGAVDDVASYYDGIGFPVPQRVNPAEFLLETVNVEFSQDKDEARRRLGEVHQAWKTSTLAEEAGARIRATHKLDDFVYLEQPEGAKPGLAGRTWLLVQRSMIKSYRDVFAYGIRLAMYMGLALMMGTVWLRLEPSQASIQPYINAIFFGSAFMSFMAVAYVPAFLEDHSVFVKDHGNGLYGAAELVLSNFLVGVPYLFAISMVFSCTAYWLSNFQPNAMAFFTWVLWLFLDLLAAESLVVLVSCLIPNFVASLAAVAFINGLWMSVGGFMVAPTRLNVFYRYGFHYWDYQKYVFESMMINEFAERTYACGGHCHCMYESPLAGECKISGRAVLEQYGYEAGGMGKRVGIMVAIILGHRLGAWVVLRWKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2P7</accession>
    <name>A0A367L2P7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_4854</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367L2P7"/>
    <dbReference type="OrthoDB" id="66546at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22572">
        <property type="entry name" value="GCP5_NTD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059169">
        <property type="entry name" value="GCP5_N_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032797">
        <property type="entry name" value="Mod21_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF33">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14609">
        <property type="entry name" value="GCP5-Mod21_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-Tubulin ring complex non-core subunit mod21 N-terminal" evidence="8">
        <location>
            <begin position="809"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="9">
        <location>
            <begin position="970"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="1280"/>
            <end position="1543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="123"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="889"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="151"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="906"/>
            <end position="918"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF14609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI08677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1569" mass="175584" checksum="A245E07B38723328" modified="2018-11-07" version="1">MLVPAICKVQLAISGQEEFRECSRYEVEWFIGRDSTEAPDLCSSPWESGHQIRKEEKKVFVRAGAGPTNARVAATSQNVLDLSFAMWWPKKQTLSNGHRSSPAPLLWPDASAKIPDRKEKASKFLAPGDIPPSRSPSHSHSKSFSSQERAATADEDKKSPDPNTNPAKHIALRSKSVPDLARLPKALTCSRTALVEQAFGQFLLDSTLQNLWPQVVRQAGNRKQAERNIGLLLRHYVDNLRGSETDSGDLERAITKFNGGGRHIISRRIVEDHCEQLNPSSSPVEPDEDDYALDNQAAEVQGAFESQCKILSHLIFDPDSFESFKTSVRLSIESGMPARRGLGSVLRQALRAGQILVENFIQSQTEQPVPPGKKRVRWTCVCTIPSKKRAERTDWLATQRCGKKLYDDYVELREGAVQDLQTILDQYYNPNLRVGDNNHPPRTPWNRFQDIVAKLGGIVYESTTQMLLPMFNQDNVAPASFGSCTAPSFKSAGAFHHGFVLLCIPYMRWATNVHHVDICGHSVAINFFKQLPLIYNKARGNQWRWWLRRVKSIEFVKFEMFHDNLVNIAMSPSIPDLPIDKRHYVHDSVEMMPPIGPNLLMHCFDDPDKMNEVLPIVLKRIPKRLGRLNVCPEKGSSYGWGLQFVEGLNEFSVVLCCSAGFVVCLVLSLVWTIVRQDGIVQWLLEPDLVQIDARSGSGLTALHCAAMYCYAACDRLALALSAAQGPGRGVKEALGVDVEFSRRGRVMAFATRLGPLVEDLVQTLTQSTAQSTSSLSDAILRKLKSHPYLRTNPFEIEDRLQGLDERFRVNNRDGLADALNQRLHSLSQHPSPWHPDVLHLLLELSDQPTFKTRLQSLDALENSRELPPEDAPLRWEEIAREDGWDRDGDLWRSPVYSNDDSDSEHVCQSSAAESSDGTSLPDDQPPPVAEDYVMYPSASEALQSVLEAQAWRTKPHQSAPCTAVPELQVVREALFMLQGFECSIFNGTADPVPDFQMADAAPETSTALIGSLAETGRRMRVLRQFVAQPQTVPHVQALQDCLCRHLADVDRKLSAMQARFASPEGEVVVSLMAVMSEIDSWVEPLLSLSDIVKRCDDASSSNAFRYLERIFDEACVAQVADKPGTYELLVRVFVECFNVYLHPVQLWMLEGKLLHGDEPFFITEPCSHVPLGDTWRSRFQIRKTVEGRPFAPSFLQPAVGNIYKAGKNMVALRLLSKEKATASLPLCQELHLDYDVLCPAGFELAPFSDLFDTAFGRWVQSRCLQLGAKLKTTVVEIWGLFTSLDSLRDLYLMAEGRAAASFCDALFARLDSTDAGWCDRYALTTAGREAFASLVDPSRLAISVDPDCRPVGSESVRAALACIKIGYRLPWPVQMIVTAESMAHYHAVFTLLLQIKRATYALHKTRSRDKSWVERQNEGQRSLFYSIRCKLLWFCATLHTYLAMQVLGPTEAQMRRDLEAAGDVDSMIGAQCSGTERMAEEACLGRELASFREKMLDVLDLAVKLEYDQRQQVEGLCLESLDDMAAAFDRLARSVCQELRGAARRSSRPASAKWDILADMLQMGVRDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L301</accession>
    <name>A0A367L301_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_4816</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L301"/>
    <dbReference type="STRING" id="1330021.A0A367L301"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000138">
        <property type="entry name" value="Flavin-containing monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000332">
        <property type="entry name" value="FMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI08806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="457" mass="51400" checksum="9D319853F3BF6619" modified="2018-11-07" version="1">MPSRFHVQKIAIIGAGPSGLAAAKYLLAQRAFSEVLLFEQQHDIGGVWLPSPAEPHCPVPQTDPFLPPEELVKLPGPRPGSVCFPSAVYDHLRANIIGPLMQFSDEPFPSTSRVFPSCEDIRACIRRYGSDVRHLVRFSQQVISLELLQDYNRWRLCAQDVHSGDVTDHVFDAVVVATGHYSVPFIPDINNMAAFHNVHPSVIIHSKQYRNPESFRNKKVLVVGNGPSGIDIASQINAVSKGRTLLSVRSATSSENLAFLGCDEVPEIIDFLVDKRAVRFKDGRLESNIDAIVFCTGFLFSYPFLKNIPSKLITNGRGVHGLYKHLFYAQHPTLVFPGLLMRSVPWPVSEVQAAAFAAVWSNELDLPEAEEMQTWSRDLYMRVGEPLHTLPPGGNFQYINDLHDWVIKASYLGKEPPRWSDLCGRQHLHMHEARRRFQEQGCQAMTWRELGFQNESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3D6</accession>
    <name>A0A367L3D6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_4934</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the complex I NDUFS4 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI08917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3D6"/>
    <dbReference type="STRING" id="1330021.A0A367L3D6"/>
    <dbReference type="OrthoDB" id="3089at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.190:FF:000001">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 21 kDa subunit mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.190">
        <property type="entry name" value="atu1810 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006885">
        <property type="entry name" value="NADH_UbQ_FeS_4_mit-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038532">
        <property type="entry name" value="NDUFS4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12219:SF8">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12219">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04800">
        <property type="entry name" value="NDUS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI08917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="199" mass="22608" checksum="B0EE9B9041349C0B" modified="2018-11-07" version="1">MASIRILTARRLWQTAAASSRAPRLSATRRFESAVATRPETLPAVPAPTQPDYDIPPDKATSTFTPVPKQIQEGNEDVLTAGMISGAPMELQARTVRIYKESKPATQSGDFRGHHWRVDWDILPKGHRWENELIGWQSSGDFMQGTHLNFETKEDAIRFADKQGYSYFVQEPCSRKFTPKAYANNFLYSPKKLKHIRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3G0</accession>
    <name>A0A367L3G0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI08965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3G0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="159" mass="17558" checksum="CC948DCFD0F226D6" modified="2018-11-07" version="1" fragment="single">ATAERTKTPLKPAFLPFSTQLCPPTSSTEVIEQRQTAYRLSPNNTLSLYSPYIKIQHVDTKTNSQTRVQEPPRGPLISFSLPNYRHEGKKKKKEMSSPPLGAVQRGSAPMQITSPSIHPPPLTPTSLPSSFIGPLALALEIKAARRKEERDNEGEKEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3L2</accession>
    <name>A0A367L3L2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_4996</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI08997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3L2"/>
    <dbReference type="STRING" id="1330021.A0A367L3L2"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF46">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="39"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="459"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="471"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI08997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="484" mass="54010" checksum="7EAD9B6DED986E9D" modified="2018-11-07" version="1">MSSDKLKHQRSDERDDVVVVECPPHTTEAKLLARIDLRVIPFLCIMYLLAFLDRVNISNADLFGLSKDIGLDGNKFNTALVIFFVSYCLFEVPSNILLKRFRPHVWLAANMFLFGFTTMMQGLVRNYGSLLACRFFLGLFETGMFPGAFYLIGMWYRRHEAQKRFSFFFSSTTLAGAFGGLLAAALGQMGGLRGYGGWRWIFIVEGAITVFTSFFFFFLLPDFPEDSEWLTTDEKHYVAARLRLDQGRSAVERAIGLRDVVAVLSDHRVILGGFMYLGLIVPAYGYAYFSPFIIHGYGYSPVQTQLYSVPPWAAAFVLAMATAYLSDRLRHRFAFAIGSILTCILGFAILLAVGNKRDVQYGALFLFAAGAYTAMPIIVCWFNMNLGGHHRRSVGSAWQIGFGNLGGIIAVFIFQKKDGPRFIPGLSIALAFAVLGILACSLYALSCLRANRERTKAGSSSSVDISEEEKTDLGDKSPDYRYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3Q9</accession>
    <name>A0A367L3Q9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_4632</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3Q9"/>
    <dbReference type="STRING" id="1330021.A0A367L3Q9"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI08842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="523" mass="58711" checksum="EC13C2B5DD40906C" modified="2018-11-07" version="1">METSATSSVFCLAAHVLSQAVYRLWFHPLSKFPGPAYMALTPLPMHFSDYIRGTWVRQVARLHRKYGPAVRIGPDSVSFDGSIGWNAVYGHRPGSGTKSAEFPKPPSVFPEGEQSLITAGRPNHRRQRRQLAHGFSDGALAQQEPILVRYVDLLLRCLSERVPDQADGGVVDIVSWLNVTTMDIIGHLSFSQPFSCLAKDGYREPWMHSISHGIQGVGLRRFSHEHPVLGCFLKAWGLSSAARALDVVRTASRQKAATRIDDGPPEDHDLGTGQHDFIAYMMRRTRDGGDGMPRRELLANAPTLVIAGSETTASALSGFCFYLSKNEAAYAALAHEIRSAYASEDEIDLRNTASLEYLQATIHEVLRMYPPAAQTQYRLCTGDVIDGVYVPEGIELNNNNVKKKKARLHVYQYATFRNPDNFTDPDSFIPERWLPPTHALYDARFARDRRSVFKPFSHGPRDCIGKNLAQSEMRLIISKLLYRFDFSLATPQDDWHESQRVLTLWTKGPLYVRLRRRLSGGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4P0</accession>
    <name>A0A367L4P0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tRNA-intron lyase</fullName>
            <ecNumber evidence="4">4.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_3727</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>pretRNA = a 3'-half-tRNA molecule with a 5'-OH end + a 5'-half-tRNA molecule with a 2',3'-cyclic phosphate end + an intron with a 2',3'-cyclic phosphate and a 5'-hydroxyl terminus.</text>
            <dbReference type="EC" id="4.6.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the gamma-BBH/TMLD family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="4"/>
    <dbReference type="EMBL" id="LKCN02000015">
        <property type="protein sequence ID" value="RCI09389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4P0"/>
    <dbReference type="STRING" id="1330021.A0A367L4P0"/>
    <dbReference type="OrthoDB" id="406634at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00250">
        <property type="entry name" value="CAS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038492">
        <property type="entry name" value="GBBH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006676">
        <property type="entry name" value="tRNA_splic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227:SF0">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="10">
        <location>
            <begin position="333"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="TauD/TfdA-like" evidence="11">
        <location>
            <begin position="767"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="559"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="159"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="564"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI09389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1083" mass="121947" checksum="8E86CE65F01C22C3" modified="2018-11-07" version="1">MAEVNGSSSGKGAWSQKRGPSVHQIYSRPAPLRTFPLPTFYPDNPLSLFHVASAWLSQLFSPPPAEPAVVHRGLWSEATSSVHVKDEKSMRALWEQGFYGKGNLSRSEPNWLKRERVRKGLQDVHVSELLTMQRRQERAQAKWERARLEQEAIHKTRMEEARQDAARRAESKGSPPTAPVGPLQLLSLPNSHVEMSPEIVPELVTEGKSFEEGLTSVKRQKSVRFSPRVQSTTFQLSDPPSPSQSPPEGCHSLARVTAPAVGGGEEPIVREHLQLTPEEAFFLSFGLGALVISEPGSDEALSTKQLLTRFRQYSYCPPRIGPDEPDLEADDGFLIHYVVYHHFRSLGWVPRAGIKFGVDWLLYARGPVFDHAEFGVIVVPSYSDVWWNRSDKEKTWAWLHGVVRVLSHVMKSLVLVYVEVPPTPRLEEALKMGIGEALALYKVREVTVKRWMTSSSTLVSNKTVQWCCSLPSSECTHLRNPADDPVPPAMVVAAVTRGCFWSRRGISSSIQHVVARTASGRFPSKPPTAFPQRIPPHLERFRYRLPVYNVDGELEPGGFVAVDDGGRDDARETMTRTRPRDSGPPRPLNSADRRAMIKALRSKKDDSASLIRETLDLFPAEREPKPEAEPLTDSRPVMTFAWSPERLYVEDEQRKLVRHVDASALRDNCACPSCRDESSGNKLFNSFDIPPDISIQHVRATDRGLWLTLANDTQGHGETTVCWDAVEVALRRRGSREGFFPRRPSIMGQTGVVFWDRRLLSGAVRAIGFDAYMSDDSAFWDAVIDLCRVGIVFLRGVPPDMNAVEAVATRIANLRDTFYGRVFDVRAGGGGDTAGNVAYSARALGLHQDLLYLDTPPMIQLLHCVENSCPGGDSLFSDAERIARLLWPFVRVSQRLAPLATRMVDYHYRGEDNRRQAAGPDRPHHHHYHQSRPVLSHDYLTGFTRVSWSPPFQAPSRLPDATLQPWIQAALFFEKLISDPEAVFRVRLQPGDCVLFDNRRVLHGRDGFDPSSGRRWLRGAYVAPDDFLSRATQMPPEQAHHYRGEDVWSSQMENQDLRHSAWWKDVSRMVLGFDPTVDERFVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L602</accession>
    <name>A0A367L602_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_3819</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L602"/>
    <dbReference type="STRING" id="1330021.A0A367L602"/>
    <dbReference type="OrthoDB" id="4685598at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000008">
        <property type="entry name" value="C6 zinc finger domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF2">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="61"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI09849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="642" mass="70996" checksum="65011D6D32C644D3" modified="2018-11-07" version="1">MKSPLNARVKRDGGGGKLLCQSPPDDASSSGPSQASADVNPLKRRMLDAGVDYPRRRATIACEVCRSRKSRCDGTKPKCKLCAELGADCVYREPGVKLDAGDKLILEQLARIESLITINMPLPAPNGNTTNQHHHLLHHHHHHLPTAAATGTSAAAAAAAAAAAAAAPVSLSASASWSGSTNISVMPKSHTNATMHLLRWPRIRQLISRPYDPQMLLQLEMAREPLHSLTKTPCVDLSNTQAYIEAYFARVNVWYACVNPYTWRSQYRTALSNGFREGPESCIVLLVLALGEASLRGSISRLVPHHDDAPGLQYFTAAWSLLPAMMTTNNVLAAQCHLLAAAYLFYLVRPLEAWNLLCTTSTKLQLLLMAPSRIPPQLRELVERIYWNALLFESDLLAELDLPHSGVVQLEEHVSLPGGFEGDDQDQVARDELWYFLAEIALRRLLNRVSQLIYAKDSILNMSSLEPVVAELDYQLAQWYESLPMPLQFPFTRTALRDPVQAVLRLRFYACRTIIYRPYILAVLENEQAVLDPSVREACQKCLEACVRQMEHVAEHQAGHMPYMWQGVLSMLSQSLLVMGASMSPSLLGILLTLVPHREALERIIGEVVIEIERCAPLAPSLGLAAEIVKGADARRRTMLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L653</accession>
    <name>A0A367L653_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ATPase synthesis protein 25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_3975</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Mitochondrial mRNA stabilization factor.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Probable mitochondrial mRNA stabilization factor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Mitochondrion inner membrane</location>
            <topology evidence="2 8">Peripheral membrane protein</topology>
            <orientation evidence="2 8">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the ATP25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L653"/>
    <dbReference type="STRING" id="1330021.A0A367L653"/>
    <dbReference type="OrthoDB" id="107372at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140053">
        <property type="term" value="P:mitochondrial gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048255">
        <property type="term" value="P:mRNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040152">
        <property type="entry name" value="Atp25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28087">
        <property type="entry name" value="ATPASE SYNTHESIS PROTEIN 25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28087:SF1">
        <property type="entry name" value="ATPASE SYNTHESIS PROTEIN 25, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="50"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI09702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="605" mass="68035" checksum="153C694F0E70485E" modified="2018-11-07" version="1">MALRPTMAALRCFACRNAVVSAVLGRVAPTIRGLPPVRAFSASQLCLSPEQDSNNRAENLPAGKSLVKAPRRTHKDEQASSKPWFLRVEPPTSPWKPHEVTLPQPPKDAPLLLAPVIKYVYEDMGLDDIALLDLRDLDPTASLGPRLMMVIATARSDRHLHAASGRFVRWLRRNYALSPKADGLMGSNLLRTKLRRLRKRAKLMGHNSMVLPEGDYGLSTDWICVSFATGNSAGKAIMGEVAQYDTSGKVSGFARTHTGTTLAVQCLTEKRRNELDLESLWQAELRESIRRKRRVNGESLNSTEVEAVVSAKLQLPRPTFTSAFQARRQEPLSQQRLFSTLARRLQANADFQSTLARSQPEDVLDDGLRVLQRQIWDMKLRVLPMDLATMERLVTSACLVGSPRENTEWERLAMVDDLLLTGQERGLTIDSPDMLVTLISSLVLSPAYGQKMAKARGNLEAVFLDKQATPTEEHVMRLMDAYARRGLWDRFTEAFRTPARFQVRRSARVYELAYRSLAASQNGVLCKDCLRWIYPEMRQEDPPVLPVGILLERLRECILLADPLVGRERKAFTRDTVLGGRRAVRREFKVMLEDAMEQCLEANVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L665</accession>
    <name>A0A367L665_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ADP-ribosylation factor-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_8398</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI09914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L665"/>
    <dbReference type="STRING" id="1330021.A0A367L665"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001166">
        <property type="entry name" value="ADP-ribosylation factor D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="149"/>
            <end position="152"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI09914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="22536" checksum="970E4D87F1F65AFA" modified="2018-11-07" version="1">MGASVSWLSGLLWAKKEIRILILGLDNAGKTTILYRLKFAQIGEVVTTIPTIGFNVESVSYQNLNFNVWVRLGGKLERTRNETRLTCWQDLGGQTSIRPYWRCYYANTAAVIFVVDSTDIERLQTAAEELAAMLNEEELKDAALLVFANKQDQPGAKGAGEISEALRLGELRDRNWSIMACSAVDGSGVNEGMDWLVQTVSQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L676</accession>
    <name>A0A367L676_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_8376</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SAPS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI09936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367L676"/>
    <dbReference type="OrthoDB" id="295029at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019903">
        <property type="term" value="F:protein phosphatase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022783">
        <property type="entry name" value="GCFC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007587">
        <property type="entry name" value="SAPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022159">
        <property type="entry name" value="STIP/TFIP11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12634:SF8">
        <property type="entry name" value="FIERY MOUNTAIN, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12634">
        <property type="entry name" value="SIT4 YEAST -ASSOCIATING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07842">
        <property type="entry name" value="GCFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04499">
        <property type="entry name" value="SAPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12457">
        <property type="entry name" value="TIP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="G-patch" evidence="7">
        <location>
            <begin position="217"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="285"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="878"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="992"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1376"/>
            <end position="1596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1818"/>
            <end position="1894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="122"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="992"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1009"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1020"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1395"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1488"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1826"/>
            <end position="1841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI09936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1894" mass="207378" checksum="E76C0E8129BF4E10" modified="2018-11-07" version="1">MPLKPRIVGMENTSVPTFDPSRLTKASAADYSSSDTEDEDDHVLPGVDVTNDFGDYNPRKKRRLAKNGKEKAALGIFGSDSDDDRPGQRWRSKTLRRKGVSFISTDAQDGKQDSSIEDEPASGGEDSISSGNNDDDDAGIGLGFKKTAQTANGPRDHQEPSIPSPVAAAKTKYRKSTNGRGFVPSVDEPVLNEEAIQPPIRNKPQPSAFNSKGKVNASSFGARMMAKMGFVDGKGLGKDGNGRNVIIEANLRPQGVGLGAVKEKTESERKEEKRQARLRGEVVIDSDEEEKRQRKAKKMSRGIAGRSASSTPRRQKTKYITAEELKAAAPGLQIPDAFAPILDMTGPEGKLITSTSGVMTPGGGVVESSEVVEARKLVKRAHAELMAFSEEWRSLEERKSWLGLELREREQEVEDLRSDLERLQSLSTLIAEQLTQASDWDEVVACLDKTMDLGAVAPEAADVAVAAIHPFFKGSDWKPLEEPAKFASDMKRLSSLFAKSSTGDGGQAINKWGSQAAKAGGVYRQHRKATTSYESMMYKNWLPRVLAGMREWDALTPGPMLSVVEEWDGAMPPFVRAQVMDGVARKLQTAVADWNPRKKRQSQQLPHTWLFPWLPFLPSYQLDAKGSGLLADVKRKIRQLVDGWEFERGVVPGLQQWQDVLGGEWRPMIMSHVLPSMAKYLQTKFRVDPADQEPYLPVLLGAMQWRAMLGDEVMGEMVVQNVMPMWMTKLQAWLALEEADLGEVADWYGWWRGVLLKELARTEVVRKELDRGMRIMNMLRPKGEAGEDQQKLRDDGRGIPSSDAELQWTRQLAGKAVKPLPSGISANPASLPTLRAASSALPLFLSLTIRLVLFLPLSPSHGRGTVFSWCDKAGSQVKEKSRARPRLSASEPKPALHEPSPSVPPSPVPFVARRPDSGPVTMFWRFGGYANISTIDTILDKPDFTLEELLDEGDLIQELKQNNSKLIQYLREEKVLSKLLDYVVAPKLEPVETPEEPAAADDDGKGRSRLLPFSRPRASSRADDSDGDEHEKRRNRYALVASEILSSETWSICEALTDNRDLIRNFWLFLSRPAPLDPLQASYFTKVNESLFEKKTEDMMLLFRSLPNVVPDLLSHVECPMIMDLLLKILALDRSDHPSCIRSHYLLFFFQWLYSKDIIPRLLSCLDPSHSWVVQTAAGDFIKAIITISANASQNEQQCIGPNELTRQLVSRPCVERLISYMLGGGNPLTVGVGIVIEVIRKNNSDYDPDFGTEANAVPSGRDPIYLGTLLRLFAENVPNFMNLIMNGPSRGQGLASTFGEKLEPLGFDRFKTCELMAELLHCSNMGLLNEVGSEQLIASRDAQRQRLRAEGKLWPQKDEDQSADDLTMRLPQANAEEARRLEITNADDDFEEVEPSREMSEDTSHEFVKAEDDMPAAPPSSFLERDDDDFMDEPLASPQPPFFGVSQHRPPLDDPELMVAPLSPSKVKPPRIVEADATDAASPQQDSSREPEERAAGEPSKLAPPELTSEMEAAPTSDLGSKAEAGSTECDGLSPHPEDTPPPLFSAPDGARPETQQSEAAAPSEPQDGRAAAPETDAVQEEEMAVAATGEQGDETTAEAAVGDFLKMQFVDYHVVPAILQQSFFFGYPWNNFLHNVVYDVVQQVFNGPMGRGFNPTLAVSLFEAADITAAIIKGQQTSDVSQAQTKTRMGYMGHLTLIAEEVVKFTERHPPELLSEMVLDKVMSQDWINYVEGALAETRERDNAILGGVRPELAMGHRGSIGGNGLAGVGLANLGTGAGPASNALAEAGLNGGLEAAESGGGGNSIGPFAISTGTLMSGFGSSSDEDDDEGDGDEEDVNSEVSGDSSEERMGTGGAAEALDEDVIMASPPGAARPGKLHSQPAAEEDEPMLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L696</accession>
    <name>A0A367L696_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8583</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI09956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L696"/>
    <dbReference type="STRING" id="1330021.A0A367L696"/>
    <dbReference type="OrthoDB" id="5334244at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="123" mass="13432" checksum="9B95CD83485B1C7C" modified="2018-11-07" version="1">MSLPTRLRLASTRRLLPRCQTLNPILNRKQSSNKDEALSSGQGAKGKTGGGPALGSTARGAPEGPPKVVNARVSAVEPERDFDDEQRREVERHNEAFERKHDVSQAAPGGDSKVDEKFWKSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6N3</accession>
    <name>A0A367L6N3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_3875</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6N3"/>
    <dbReference type="STRING" id="1330021.A0A367L6N3"/>
    <dbReference type="OrthoDB" id="331602at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032185">
        <property type="term" value="P:septin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07650">
        <property type="entry name" value="F-BAR_Syp1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000102">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018808">
        <property type="entry name" value="Muniscin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF54">
        <property type="entry name" value="SUPPRESSOR OF YEAST PROFILIN DELETION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10291">
        <property type="entry name" value="muHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCH" evidence="4">
        <location>
            <begin position="24"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Muniscin C-terminal" evidence="5">
        <location>
            <begin position="648"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="268"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="358"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="549"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="120"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="286"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="299"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="413"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="576"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="615"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00611"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI09882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="918" mass="98211" checksum="7A3121F3C77A5A50" modified="2018-11-07" version="1">MADLARVEYPGLLANMVPGQAVMTLNERVKRINRINLEIADWLQERRRVEEQYALGLRRLAQHRVPNSHSELGVFHAPWLRIIEAIDRIAKSHHLFAERVEQDIEYPLRAFQQRRDYQGMHNISTNLAVLARDLEDAQEKAERLNRRGGRASTQKVDAATAKLESATQQWESQAPFVFETLQALDESRVNQLRDLLTQYQTHEASQAQRAQDNAVETLAAMLEISTEKEIQDFARRAVANKSSLSAQPSHSSHANPVRSVTRRLSMATAAATAPLHRPVTSSAAAAPPPVLPGPPVGPPAASTTGATSSAHPPPPPPPAATTLPPSAEDGAADPDSFPVDAKPESKLRRLGTMFGNRRRQSVFGGPAGPITPQRTGPAAFGRTTSTHSRGVSPRPSMSRLHQDHGRLSALDEMPDRLRNDVSTTDDSHHGETNGVLAGAENPLHLSTTGAGASADLAGMNGNHDMEVAAVLPPPGPPPGQQAADGSSSPAKDQEGYSVRAPMNDPISEAQREATGEDADQLLRLSILNKPVDEEDPEAKQAALSSVANTLKAGTATRRSSTLRGRRDIRNTMHIPTPTTSIRESQSDGAMPSIAGSPPLTSSSFSRPTPGAALASETSVAGTSDSQSVRSGNSLGSMGHVKHPDMTGPGLNGSVIETISAVFEDGEAKSATVTGEIAFVNNAFQAGGKAQETIRITTVPKLDRLGPNRIFVQNSATDQPQQFLLDVTHLAKTMTAFSYRVCSEESDSLALGSRVPLLLKPSWKPHGEKLGFLLQYQLNTQLTGPLTLHNVVFVVTYEGNATTAQTKPSGTHLRDKHLVYCRLGDVTLTSGSMQKVVCLIVGADGVAPTPGLVEARWECAGTDALGSGISISRLDEDGEKAGTATEDDPFADHSLAAAGHNWVSVPLHRRLVSGKYEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6P5</accession>
    <name>A0A367L6P5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase S58 DmpA/arginine biosynthesis protein ArgJ</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8567</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S58 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6P5"/>
    <dbReference type="OrthoDB" id="2107894at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.70.12:FF:000004">
        <property type="entry name" value="Beta-peptidyl aminopeptidase BapA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.70.12">
        <property type="entry name" value="L-amino peptidase D-ALA esterase/amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005321">
        <property type="entry name" value="Peptidase_S58_DmpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36512:SF3">
        <property type="entry name" value="BLR5678 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36512">
        <property type="entry name" value="D-AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03576">
        <property type="entry name" value="Peptidase_S58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="DmpA/ArgJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="407" mass="43888" checksum="D7AE063F008F3D77" modified="2018-11-07" version="1">MSQHKSFGRGRVREVLPQLYLGRFSTGTLNSITDVPGVLAHTQSLQPDRDVNTGVTVILPSKDWLQNSSFAGVFRFNGCGEMTGAHWINETGILCSPIVITATSSVGEGYRGVMNLLYQRYRKEAEDLFMLPLVAETYDGFLSDAGRFAVTPEHIMNGVDSASGEAIPEGNTGGGTGMICHRWKGGTGSSSRIVCGAAATYTIGVLVQANYGNKEDLRIGGIHIGRLLRERHEHRRSSGPEPRKDGSIIIVIATDAPLLPIQLQRLARRATVGLARVGGHGHNNSGDIFLAFSTANKVPFQIMPPEGTPFPDAPHTRAVEMTDNDSINGLFDAAADAVEEAIYNALFMAETMTGFRGRTIEALDLEKVKKIFAGRDGATRSLAARPPTTSLPPRLLTPPKQCFITSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L722</accession>
    <name>A0A367L722_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7820 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_8513</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L722"/>
    <dbReference type="STRING" id="1330021.A0A367L722"/>
    <dbReference type="OrthoDB" id="5384459at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056722">
        <property type="entry name" value="DUF7820"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42078">
        <property type="entry name" value="GLUCAN 1, 4-ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42078:SF1">
        <property type="entry name" value="GLUCAN 1, 4-ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25130">
        <property type="entry name" value="DUF7820"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7820" evidence="3">
        <location>
            <begin position="334"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7820" evidence="3">
        <location>
            <begin position="530"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI10209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="634" mass="69090" checksum="1999039B7610C7BB" modified="2018-11-07" version="1">MDSPDGGPERRPSTWRQSVASDFDGHCPGENAVADGFRPHQATAPQPPRTSTETLQRPSSISKPPQAHDSLTLRNDGTSRRHPEMPASPNAGAFILPDGSYQGLTGPSHPYSMYPQEALDEAASSTAPNVAHTAPAHPYALYTQTIGDDDAAVRQIAYQRQTSAGGDETGDLLGALAPVEELPPYTRYPEGPSARPPREAAPDAMRAVPPIAISGAGGLGRATRDPEFSSAEDELPTASTSHPVTPGETASQHEINTAARDFSEKTAPLTTWQRRAKKKLWGIVPCWAIALLVVGILIVGVVLGTVIGTVLSKRAKADGHGDSQAEGVSRSPSSDIEPLRVVPASLPPLVTGAFCLPPLDISQAPRSCFNDPRQAQAWSCEMPFRFYAMAISRDTDAPATRGYTLSLTARNASDSKFLWGTQPPDITSPQRLTLVDDTFERNRGPAWWMLTKFNKTVVIDEDKISRRLSKRDGPPVLRPKTIAKRRGAELGDKPWICTWPDTTLEIFIYPSQSTSYAASPSGADAAMSDFMHDPMSSYPMVVKLLERRWCNNPQQPMVRCRQVEIIAEGTERSLEDENGNPIEVIIDESWRSAEERVAQRERERHPGASQAAYNDIYAREALELTDCGCLWLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L775</accession>
    <name>A0A367L775_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA mismatch repair protein MSH3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3 10">DNA mismatch repair protein MSH3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">MutS protein homolog 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_8575</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Heterodimer consisting of MSH2-MSH3 (MutS beta). Forms a ternary complex with MutL alpha (MLH1-PMS1).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L775"/>
    <dbReference type="STRING" id="1330021.A0A367L775"/>
    <dbReference type="OrthoDB" id="276261at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000870">
        <property type="entry name" value="MutS protein homolog 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011184">
        <property type="entry name" value="DNA_mismatch_repair_Msh2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007861">
        <property type="entry name" value="DNA_mismatch_repair_MutS_clamp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007860">
        <property type="entry name" value="DNA_mmatch_repair_MutS_con_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF21">
        <property type="entry name" value="MUTS PROTEIN HOMOLOG 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05188">
        <property type="entry name" value="MutS_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05190">
        <property type="entry name" value="MutS_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005813">
        <property type="entry name" value="MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53150">
        <property type="entry name" value="DNA repair protein MutS, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="12">
        <location>
            <begin position="689"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="7"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00073774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI10275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="868" mass="96675" checksum="60ED88329D685D3F" modified="2018-11-07" version="1">MSRHNNSFAGSTPSSSSAYFSPSSQLLSSTGSQTLSSTDSPLRPSPAPQYTPSVISTGFSTGRSTSRTASGRSKSRAGTVSSILGLGEQQNIICALGESRGVTPSVGVAFVNASLGEVILSQICDNQSYVKTIHKIQMLTPSRIVFMSSACPPQKSSTLFTLVHELIPEARCDAFDRSAWSEHAGLDYINRLACPPDVEPVKVALHGKYYSICSFAAAMKYLDHQFSISFAPHSLRVRYQPSEDTMMIDISAIQSLEIMQNLHNPKSKDCLYGLLNHTSTPMGARMLRSNILQPPTPRDSFIAPRYDALEELTTSEEMFREVRTALKLFHDVERLLTKLIIIPCDATMVQMEEEIGQILMIKSFLESAPKLFKALGPARSALLVKIREFCHPRITGPVLAEIRSIIEADVTYLKSPLDLRNQRTFAVKTGISGMLDVARQTYKELTEEVHQHVDRLNEEFRTRATLKFDNGRKYWLRFKASMFPSGTLPPVFINQVRKRDAVECQTLDLVKLNVRLSDTSNEVVIRSDAVVRDLMQDLRQASPQLFRVCESVALVDMIASFAQLATTRGYIRPEMTDTLALKSARHPIMDKTLDGNFIPNDYYATEQYSFHVVTGCNMSGKSTYIRAVALLQIMAQIGCFVPAEYASFPVIRNIFARVSLDDSIEASLSTFSVEMREMAFLLRNVDKDSLAIIDELGRGTSTRDGLSIAMAMSEALLETRASVWFATHFVDLARVLAQRAGVLKLHLASETSETVGGLPHLKMLYKATAGTVDEQEHYGIHLARAVGLPSSFIERAEEVAKSLRRTREESRQSSESHRLVARRKLLLNLHGALVQARESGSEEALPGYLRRLQEEFVHRMEELDDMNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7B0</accession>
    <name>A0A367L7B0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Deacetylase sirtuin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_8465</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7B0"/>
    <dbReference type="STRING" id="1330021.A0A367L7B0"/>
    <dbReference type="OrthoDB" id="420264at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046970">
        <property type="term" value="F:histone H4K16 deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF9">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="9">
        <location>
            <begin position="149"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="323"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="493"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="326"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="346"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="493"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="277"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI10298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="520" mass="58254" checksum="C3524DB07FEFF9F8" modified="2018-11-07" version="1">MKRGPKGHTLRRKKADKLAKNPTLDEVKKTDAHISLTELEERVNDVRESWETDSLFEDALEELSGDAPLTVDDGSCCSPEEAGRLRRELREYGPAVFCQRTVDAGRYTAKKLLTAFNIRPPPFLQGQVDEAYYSLLSLAISRELSKRAKLSRWNSVDDAVSLLNHCSNIVVITGAGISTSLGIPDFRSKGTGLYSKLEHLGLADPQEVFDIDVFKQDPSIFYSVAKDIVPATDRFTPTHQFIAMLHQRQKLLTNYSQNIDNLEVKAGLPRDRLIQCHGSFGSATCIQCRHRMPGDDILPHIRAGQVPPCPRCVKALRANGALSGSLKRKRSSGTDKKRRRWSDQSSGDDDDGDDDDDDDEPQAGVMKPDITFFGEPLPDEFSRRLTEHDRDKVDLVVVIGTSLKVTPVSEIVSWLPPHIPQIYISRQPVNHINFDIDLLGDCDVVVAELCRRLAWPLCHDMAVPDDQEIEVRPEPGYTSRHVFELVKPHTTNTTNTTNTINTINTSTTADEKKKKKKKKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7D2</accession>
    <name>A0A367L7D2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_4438</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7D2"/>
    <dbReference type="STRING" id="1330021.A0A367L7D2"/>
    <dbReference type="OrthoDB" id="361013at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03368">
        <property type="entry name" value="Ribosomal_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000099">
        <property type="entry name" value="Ribosomal protein S12, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005679">
        <property type="entry name" value="Ribosomal_uS12_bac"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00981">
        <property type="entry name" value="rpsL_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01034">
        <property type="entry name" value="RIBOSOMALS12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI10321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="179" mass="19042" checksum="C55888F49652AC0E" modified="2018-11-07" version="1">MAAAAAALVRHLLPPSARPPLFSYTAVFIRPVVAPLLRFSPLHTTAPRAATLNQVLRGIRQGKRARHATSPALASCKAPHLKGVCLRVGVVRPKKPNSGERKVARVRLSTGAVISAIIPGEGHNIQQHSVVLVRGGRAQDCPGVRYHLIRGALDLGGVANRTTSRSKYGTKKPKKAKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7V9</accession>
    <name>A0A367L7V9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7V9"/>
    <dbReference type="STRING" id="1330021.A0A367L7V9"/>
    <dbReference type="OrthoDB" id="2326446at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="275" mass="30882" checksum="9034E7C241952123" modified="2018-11-07" version="1">MQAFSTTLAAMGRASTAPPALKTASRQRCRVELIPWDGTDGAHVSRLMAQREACTWAQDEVLAWRELMVQGVKTVFWVALAEDEDDDDDDDDHSSPMREVMLRTHCHEFPNELEPLFDTAPTIAANARTPSARAFHPVGHVALEALFDRNARFDLPCATYWVKSLYISWPLQFSGLGSAAMSQLERIASNPPFNSDYIALDTLPADFQRSEQVQSIAFDARGLPRPLEMRTNEDWFRRMGYRVIGADQALYRRFDPVSGSEVAAMPGLFLTKALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L809</accession>
    <name>A0A367L809_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">R3H-associated N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_4425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L809"/>
    <dbReference type="OrthoDB" id="10256743at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025952">
        <property type="entry name" value="R3H-assoc_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13902">
        <property type="entry name" value="R3H-assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H-associated N-terminal" evidence="2">
        <location>
            <begin position="82"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI10555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="350" mass="39329" checksum="780D88351D008704" modified="2018-11-07" version="1">MAIYSAVPPPAEFTTGQQQQQQQQQQANNDVDAWTVSALQSLTVSPVARGTGATALAIPIDGQDRSAQTVVGPKATVSTTPRPPSRRDSQRRRDALLKGHEGSRQRRRWDNDRLVGVPNVQPPLPCDWQVRPTHPVHHIPYQLAHFWDCGMRQRAQDKAATLAAARKKQQRTTGSATGLGVGEVPRDLRESAKRSPNVRFWVRALEEPVRSYLTGDGVKDEEEKEEEEEEEEEEADDSAAERMDSDDEEIVFVGRSGAMRELREKRESRCKMARREVDHRTVDSGVVFDSFGDGDAAAFKRWLAHSISDYYGLSSRSVTLADSSCRVVYVGLKQEERRRGELPRPLWEVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8B8</accession>
    <name>A0A367L8B8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NEDD8-activating enzyme E1 regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_4234</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Regulatory subunit of the dimeric UBA3-ULA1 E1 enzyme.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 4">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8B8"/>
    <dbReference type="STRING" id="1330021.A0A367L8B8"/>
    <dbReference type="OrthoDB" id="1708823at2759"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030667">
        <property type="entry name" value="APP-BP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF29">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039099">
        <property type="entry name" value="APP-BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="5">
        <location>
            <begin position="22"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI10665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="546" mass="60539" checksum="A4ED073CEAD63A1E" modified="2018-11-07" version="1">MASDLVNVNADVDIPPDKDKKYDRQLRLWAASGQTALEHANVLLVNSGGATVGVETLKNLVLPGIGSFTIIDEAIVSDEDLGVNFFLDESDRGKSRAQCCMNHLLELNPGVRGSYYPRPNVRNVPQIFDDSVDFTRLDLLDVLVSTGPFSIILYVLPLRSDQLAILQTHMQENHTPSIAVQSVGLYSYFHVLLPGEFPVVETHPDEASTVDLRLLSPWPELVAFTAELTSNIDELSEFAHGHLPLVVILLHYLSVWRDEHDSANPVTYSDKVAFRSMITNAMRRNNAEGGEENFEEAISSVMKLVKQHSLPASLEAIFERCDDYKDVPKSQFWTIVRVVKQFYSRNGQLPLPGSLPDMKAESAVYRRLQKLYKEKAQKDLCDVLGLVRTMAGGDTITKAEVELFCKNARFIKLVNADKRTKLTIDEIIEKELAQNEIAANAGYGVPASLIPIYLALTAIGQLATMSEDNILSCIVRRAPALTGVQSAVLVCKEASRFATGELHNISALTAGMVAQEMIKIITRQYVPIDNVCIYDGIESRCHIIQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L962</accession>
    <name>A0A367L962_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">GPI ethanolamine phosphate transferase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L249_5340</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Endoplasmic reticulum membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L962"/>
    <dbReference type="STRING" id="1330021.A0A367L962"/>
    <dbReference type="OrthoDB" id="272139at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051267">
        <property type="term" value="F:CP2 mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16024">
        <property type="entry name" value="GPI_EPT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019434">
        <property type="entry name" value="DUF2423"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037674">
        <property type="entry name" value="PIG-G_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039527">
        <property type="entry name" value="PIGG/GPI7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045687">
        <property type="entry name" value="PIGG/GPI7_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23072:SF0">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23072">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19316">
        <property type="entry name" value="PIGO_PIGG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10338">
        <property type="entry name" value="YBL028C_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 12" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="481"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="570"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="597"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="641"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="714"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="753"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="793"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="831"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2423" evidence="14">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="domain" description="GPI ethanolamine phosphate transferase 2 C-terminal" evidence="15">
        <location>
            <begin position="441"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="37"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF10338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF19316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCI10772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="860" mass="94883" checksum="F805C56F2AADA109" modified="2018-11-07" version="1">MAKSSRASVKKENNRRKAVSIYGPAELARNERLSTKLLEVARQPKPEPSTDVVMETESKHDEDAMESDNIETDNKVEDGETAMDVDIKEPLIRDGAAIPFTANARTPTVTMPRLKAITTGSIPSFVDLILNLDEADTSSSLAQQDSWLAQLKAAGKGKLLMYGDDTWLKLFPETFDRHDGTSSFFDFTEVDHNVTRNVPMELDRSDWALMVLHYLGLDHIGHKAGPRSFNMVPKQREMDGIVKTIFKSIESNDHLQSTLLVLCGDHGMNDAGNHGASSAGETSPALLFLSPKLRAISRGLPAPTQPRTEFDYYAAVEQSDIAPTLAGLLGLPVSKNSLGAFIPDFLPFWPSSSDKVQILIRNAKQILGIVTAAFEPYLFDPRSTADPCHMDATDVNVLACDWRRISRQSVSMASSAKIDPAWLSDTATWLRKAQDLMSNMATKYDVTKLTVGYVTAMVALTMACLAALAQSTSADGNSLPLVIVTLSYGVMMFASSYVEEEHHFWYWSCSLWIAWLGLRSIRRARGLRPAFYHLLTLGCLRLARSWNQTGQKFAGEPDVVKMFLVPNPQLTWALVTLSYAVVAFQIIGNLYGFPLALRLSLTSVLVSAAFSFKLAFTAHDAPELVTGLASRVNEALQGPSLILRFRTLFFFLALFTVLAVVRRNHGGRFVQPSARLLHNLYTLFAMTQSRALNIPLLVLASVVCRCLEMDDLSVADVTTSCLLLQHVFFFAFGGSNSISSVDLSSAYNGVSNFNPVAVGLLTFVSNWAASIFWTSAANLVLLQRHGRGRNDNYFNHIMLLTLFATVSMAFVMAACTALRTHLFIWTVFSPKYLYCMAWTFGQHMSVNVAIGALLHRFGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9E9</accession>
    <name>A0A367L9E9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI11048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9E9"/>
    <dbReference type="OrthoDB" id="4924443at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="463"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="539" mass="59042" checksum="5E5B607DEE40B767" modified="2018-11-07" version="1">MAQKGRASVWEGHRRRWRVVIVEGVCRVLISILRDKGYSFDFISSCKGQRREESKLQKREKEETQVATSSEHVSLLGITKKKKAHNMIDRVDGESYDQVELAGKKKTSPPLPPPSPPDVPSGSSSSSSNNPFIIITILDSTMKELIILGLTALSHAAMSPDIAPSSRLLTEPGSPPPPPDWLRRQTESIWNNEQKCLRALSREFHTPQDRFKLCRYFLNEDEGDDHVASDVRAKALRILAECDPVTASGVCTKLEGPPSVSTKTSCFEKLKMDLLKNPDRAWEVCRQTYELGEEGVVQDIDTTASDIDVDIDRPLPRDEEARDEEEEEEEEKEEDQAPESCYENREVIAKACRSIGAPESLGMPGCRGQKSYDETIKLLTLAGLNRLCDQVDRGQHLSESAIGSVASETLTPKAVKEAVEAVREGCRCHREQRARSHEWISSVVGDGGLKTSVRPFAASQTGVVRGGDGLEESSDGRGFGSAAGLSRFADEADGGDGGDGGSGGDDDAGVVFSGVVLADFRFITKEKKEKPLLDIGKML</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-09-13" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9H6</accession>
    <name>A0A367L9H6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9H6"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016777257" description="Secreted protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="74" mass="8153" checksum="7E1F94A904B55B2E" modified="2018-11-07" version="1">MLIRRLIVLLKKACLAFPTSVPRLPDLPYVPSLVRPVRPVRPLCNVRRPRAGYGRPGVTVSSAPAKLTPQLSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9N9</accession>
    <name>A0A367L9N9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5317</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9N9"/>
    <dbReference type="STRING" id="1330021.A0A367L9N9"/>
    <dbReference type="OrthoDB" id="3357271at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="327"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="377" mass="38480" checksum="7801BEABF07F38A9" modified="2018-11-07" version="1">MNEFKDIVKNGWHPEKDGTTPPKRTTFTSSSTSSSSSPPSTKNEFKDIVRKGWHPEKEGTTLRGQVHASRPLSDLTDPSSFAPPPRRAAAAPSSPPIRAPLPPRRVQPAPSTLYDPRAARNQSFASSSSAATSAAGTTTTTTTAAAAAARDDSSHPPPPPPPYSAVSNASAPPPRLPPRKSSSVVGGGDDAVARANPGYLEGCLNQGATTRLGAAGISVPGLGIGSAASPQPAASPSPSSSLSTPANAEGTTWAQKQSALKTAASFHKDPSSVSMADARSAASTANNFRQRHGEQVKAGWDRASGLNQKYGVTDKLGAFADKHHLSADSSSAAAGGSKKPPPPPPKKKPSLGSFSPTDSGGQDGGAPPIPSSTRPKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9T5</accession>
    <name>A0A367L9T5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_7266</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the proteasome complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9T5"/>
    <dbReference type="STRING" id="1330021.A0A367L9T5"/>
    <dbReference type="OrthoDB" id="204949at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03759">
        <property type="entry name" value="proteasome_beta_type_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000003">
        <property type="entry name" value="Proteasome subunit beta type-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033811">
        <property type="entry name" value="Proteasome_beta_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF10">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI11179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="205" mass="22331" checksum="4B2AFD9FC31B3F80" modified="2018-11-07" version="1">MSSPFSINGGACVAMVGKDCVAIACDLRLGMQALTVSNNFPKIFQYGDVFLGLTGLATDVNTVSDLFRFKVNMYRLREERAIAPRTFANLVSSSLYERRFGPYFVSPVVAGVDPKSGLPFICGFDSIGCIDFAKDFIVSGTASDQLFGMCEGLWEPDLGPDALFETISQCLLNAVDRDALSGWGAHVYIIEKGKVTKRLLKGRQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9W1</accession>
    <name>A0A367L9W1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7583</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9W1"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI11205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="74" mass="8557" checksum="BF657D8F850A69F1" modified="2018-11-07" version="1" fragment="single">KVKADNKLEYNNVAIRYTFLFYSASIAYSAPIDVQRADRYNDCCNESIGRYDRYSPTVTQGVVAGLRSNWYNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9X0</accession>
    <name>A0A367L9X0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5451</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI11042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9X0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI11042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="87" mass="9059" checksum="C9145D8A2B422092" modified="2018-11-07" version="1" fragment="single">DSGAISKGGSRNVLAENRYLGMQIVALIYIEEGPALALNKTVREGVDVGAVLRCARPCLVLEATGSRRVCGSSPILVLAGYFAIPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAH7</accession>
    <name>A0A367LAH7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_7298</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAH7"/>
    <dbReference type="STRING" id="1330021.A0A367LAH7"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="321"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="688"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="47"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="92"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI11421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="870" mass="98352" checksum="F61C2A57DE306AE6" modified="2018-11-07" version="1">MDAETKKRIRQIIDVFGCQYSIESIREALRNCHNDLDDAVNWLQSRPLRKSPSLPSPPPPTPPPPPPPPSRRLVSKGKLKQQAINNNNKPLPRSSPIASPQSSPQSSPPKQPRRRLVQGLRKEAMDAPSSDDPLTVDDKDAFRLQDSPEIAADDHEQARVLACINSSPLAELVAMTGLKESLIQPLVDKRPFVGLDQARRVSSTNKKSGSRKAVKISVGESVVDAVGIFLRSVSAIDDVVAKCEVKAQMVKTVVDGWELDSFGFNKNSSGRASPDKDLPPTPSSLPANSRYKRPLLPRQPRLMDGHCEMKPFQLFGLNWLALLYNYDIGCILADEMGLGKTCQVISFICHLVEDHERKGRRGRRPWPNLIVVPPSTYNNWLMELERFAPGLSVVGYRGSQSERAEIAYDVREEPAAYHVVLATYSQINCETDVEAMQSIRLNAAIFDEGHKMKNPETKIYQDLRRIPASWKMLLTGTPVQNNLMEMTSLLSFINPRMFEGCMKHVQYIFSQKISIRDVSNEAFLYNERVRRARTILGPFILQRRKDQVLSSMPAKYSTIVRCEMSETQRSVYDEYEKLFKMEPRQRGASEATRRGRQNDQNNVWMQLRKAALHPLLFRRHFTDAATEKMGKLLMERVPQSELHQPDLGHLIEELRHSSDFELHLWCRDYPRLLQQYDMPASAEMDSGKVKKLLELVEGYQAKGDRALVFSKFSRVIELLQEVLALREIDHRVLMGNTKVAERQALIDEFNSDPTIAVFLLTTGAGGTGINLTAANKVIIFDQSENPQDDIQAENRAHRLGQTRDVEVVRLISSDTMEELMLKACRKKIELAEKVTGAATACEFEEFGGDGRMELEVRKMMGQQEMTPGLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAL8</accession>
    <name>A0A367LAL8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_7312</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAL8"/>
    <dbReference type="STRING" id="1330021.A0A367LAL8"/>
    <dbReference type="OrthoDB" id="5600212at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF10">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="51"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="625"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="731"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="757"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="779"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI11461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="878" mass="94930" checksum="C3C71C3DAB4C755D" modified="2018-11-07" version="1">MHTDTLMADSSDNGSPIGHGADGIVCAGDAPPRDLSSVHDNASIPKPKRLACMICRKRKLKCDGLRPSCSTCSRLGHSCAYDEQRRKSGPKRGYVKALEERLKQVETMLKTQDSVPPTTSPTKGIGGVSVTGGLSAANLSMSLAPDRDMDGRWQQHFPGVESPQAAAMDDFGFNAGMAMPVNHVAGNFSWEMIGLGLEEPLPPQDTIDELHQVYFEKIHPSVPMVHRYRYLAAMNLAPNQRPPVCLRYAMWTLACSISDRFSDLKHLFYQRARKYVEADYIKGYGEHMISIAHCQTHVLLACYEMKMMYFPRAWINTGSAVRLAQMIGLHRLDGTGLDVKQCLPAPKDWTEREERRRTFWMTFCLDRYASIGTGWPMTIDERDIMTKLPASEEAFDMSKPEQTQTLTESLSSSGAAKLSSFGGIVLMACLFGRNLVHLHRTDDSDLDHDLNGPFWKRHRHMDGILLNTLLCLPPRLKLPAGLSNPNVVFTNMSIHTSAICLHQAAIFKADKNKLAASVTAESKVRCITAANEIASIMRTISHMDLSAANPFMAFCLYVAARVFVQYLKSRPEDSHATDSLRFLLSAMNVLKRRNPLTESFLVQLDVDLEALVARIPRLRNAFHRSGDSVSPKMADSSNPGGGSKAGPPGEDEDSRQGMLTFRGDCHFIKVPGSESNAVAAPDLVEARGDGQGGSSTSAGGFGQAWLAASDGCSMPVVSVLTPSSSTLYEKNMSGFGEGGPVVDRGGMRDSPEGGHSNGPTPNSSAPGSDGKPQLAPGTGQESYRASPTSPQQNLMGQHGGVEAGGFYGSPSGYTAASGARPHGADYGVPSNGWTGMSGAGGMQPMGEGVIRALMNMGPMDAMDLTSWDSGADTTHMRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LB11</accession>
    <name>A0A367LB11_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">CDP-diacylglycerol--serine O-phosphatidyltransferase</fullName>
            <ecNumber evidence="5 18">2.7.8.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16 18">Phosphatidylserine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">L249_7522</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 18">
            <text>a CDP-1,2-diacyl-sn-glycerol + L-serine = a 1,2-diacyl-sn-glycero-3-phospho-L-serine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16913"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="17 18">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18 19">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.8" evidence="5 18"/>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LB11"/>
    <dbReference type="STRING" id="1330021.A0A367LB11"/>
    <dbReference type="OrthoDB" id="448573at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00615"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003882">
        <property type="term" value="F:CDP-diacylglycerol-serine O-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006659">
        <property type="term" value="P:phosphatidylserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000022">
        <property type="entry name" value="CDP-diacylglycerol--serine O-phosphatidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050324">
        <property type="entry name" value="CDP-alcohol_PTase-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004533">
        <property type="entry name" value="CDP-diaglyc--ser_O-PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016271">
        <property type="entry name" value="CDP-diaglyc--ser_O-PTrfase_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00473">
        <property type="entry name" value="pssA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14269:SF61">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000852">
        <property type="entry name" value="Phosphatidylserine_synth_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 18" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 18" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 18" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 18 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="14 18" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15 18" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 18 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00032361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00060701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR000852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RCI11432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="219" mass="24004" checksum="B2C89D6BD9B59AED" modified="2018-11-07" version="1">MEKQKMLLSSDLVGHFSLVRAMHLADLITLMNGFCGVMSIFSSLRYTLASPDEVEYAWLALALLPFGLVFDFLDGKVARWRNKSSLMGQELDSLADLISFGVAPAMIAFTLGLRSPIDTVGLTFFVLCGLARLARFNVTVAALPKDASGKSAYFEGTPIPTSLAVDALMAYWLHKGWILQDLPFGVCFPDSAIEFHPALVIFLLHGCLMTSKTIRIPKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBC8</accession>
    <name>A0A367LBC8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Alpha-galactosidase</fullName>
            <ecNumber evidence="5 13">3.2.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Melibiase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L249_7737</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolyzes a variety of simple alpha-D-galactoside as well as more complex molecules such as oligosaccharides and polysaccharides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the glycosyl hydrolase 27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="5 13"/>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBC8"/>
    <dbReference type="STRING" id="1330021.A0A367LBC8"/>
    <dbReference type="OrthoDB" id="5795902at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23425">
        <property type="entry name" value="beta-trefoil_Ricin_AglA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14792">
        <property type="entry name" value="GH27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000177">
        <property type="entry name" value="Alpha-galactosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002241">
        <property type="entry name" value="Glyco_hydro_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041233">
        <property type="entry name" value="Melibiase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452:SF91">
        <property type="entry name" value="ALPHA-GALACTOSIDASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11452">
        <property type="entry name" value="ALPHA-GALACTOSIDASE/ALPHA-N-ACETYLGALACTOSAMINIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16499">
        <property type="entry name" value="Melibiase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17801">
        <property type="entry name" value="Melibiase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00740">
        <property type="entry name" value="GLHYDRLASE27"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="9 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0430">Lectin</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016843025" description="Alpha-galactosidase" evidence="14">
        <location>
            <begin position="22"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="15">
        <location>
            <begin position="417"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCI11542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="541" mass="60012" checksum="B91AD9AEACCEAA43" modified="2018-11-07" version="1">MFRFLRFVAVTAAGLIDAVTSFRVPADRILPLPPMGFNNWARFQTDINESIFVDAAEVMTRNGLRAAGYNRINLDDAWSTMSRAADDSMVWDVNKFPRGLPWLAGHIKSKGFIPGIYTDSGSLSCGGYPGALGYEDIDLRAFTAWGFDFLKMDGCNLPDASEKTYHEVYGRWNNLLSQSGSRMVFSNSAPAYFSGVKNLTSWYMVMGWSRKYGHLARHSADIQTYPEGDSWISMMYNYGQHVRLSRYQKPGFFNDPDFLNVDHPSYSLTERKTHFALWCVLSAPLLLSTDLKALKDKEIEYLTNRRLIAVNQDSLVQQATLVSRDASHDVLSKSVQNGDRVVAVLNKGDAPIRIMISWERLGFSPVSLQKFDYVSAENLWTGKRQKLAVAAGGVRTEAIPSHGTAVYRLSQKASAITPTGLIFNSNSLKCLGEDWSGVVGWYDCNDSDSQVWMVRRDGRISSLLHPDGCLMHGDVNLVYTANSPGQNCGKWTYHVSGNLINSKSGYCLTERANGVAVVASCGYLLNEQVLSLPIGVEVVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBH7</accession>
    <name>A0A367LBH7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7549</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBH7"/>
    <dbReference type="OrthoDB" id="4908749at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="151"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="432" mass="48464" checksum="2D23E89F64BD4A32" modified="2018-11-07" version="1">MIPLLGVVILSFGLRSKAMKLHGPLDLASLHLEEPEVKFIFNRVKRAVTGRTIPYFDVYLHENRTQLGSDTRERFVNSRLGLQCGPGLFYRHTVLSGYEVNLQPFAHQDFESVNTHWNQEASITLTQTTATTEDTSVEWRVDSSVTESRQDTTTETSEESLGGSIETSTSFKIQNTTNYFQSAKTGIDFYGFSMETAAHDSFTYMNTAITSSKDSQSNGEKSTESFTLSDALRSTTTSGQNSNRGNSKTFTQDLSLTVSCPARHLCEVQTWTFTAKVKGSCALIPFFDFGRCPIHDGLAKAGRYDMKKGKFEYQLLPPVNITLGALNLTFENRWFEYVRSMFMTGPYIAKDKSRSHDVGNGLVYPASNVKVKYINTAHCEVSFPLLQSGGMPYRVQILFQEKLPSPSARRRRYATPGKKNKVGVRVLYSDFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBI1</accession>
    <name>A0A367LBI1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7389</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBI1"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="88" mass="9822" checksum="57EB66090B2FF1C3" modified="2018-11-07" version="1" fragment="single">PLLSFSFGIAPSAAPPDRAPGDTIGVPIVINRGPKGIAQRTRPPFLLLLPVQSRNLSNRPYKRFYNPMRLGRNRPRPPYSLPPLPHYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBR1</accession>
    <name>A0A367LBR1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7407</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBR1"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI11672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="117" mass="13393" checksum="A768668DE7F2479F" modified="2018-11-07" version="1">MSNQGVDHVIEKKKTNYVIVVLSDKVKADNKLEYNNVAIRYTFPFYSASIAYSAPIDVQRADRCDDRCNESIGRYDRYSPTVTQGVVAGLRPNWYNLFQVALQAYFLSVQDEKICVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBW0</accession>
    <name>A0A367LBW0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_4192</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFB1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000009">
        <property type="protein sequence ID" value="RCI11910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBW0"/>
    <dbReference type="STRING" id="1330021.A0A367LBW0"/>
    <dbReference type="OrthoDB" id="360521at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13229">
        <property type="entry name" value="PH_TFIIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3970.10">
        <property type="entry name" value="BSD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005607">
        <property type="entry name" value="BSD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035925">
        <property type="entry name" value="BSD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027079">
        <property type="entry name" value="Tfb1/GTF2H1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013876">
        <property type="entry name" value="TFIIH_BTF_p62_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12856">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03909">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08567">
        <property type="entry name" value="PH_TFIIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00751">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140383">
        <property type="entry name" value="BSD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50858">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BSD" evidence="7">
        <location>
            <begin position="228"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI11910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="642" mass="71430" checksum="237E5C9725A6D37A" modified="2018-11-07" version="1">MDIPFGRTIFKKKDGILSLTSDYETVIWTPTSASAPIISLPVSRISNLQQTPDSSSKVMLKIFEKADNEIEPATYLFHFYSSDARADAKAIKDVLSRLLANIRSNDTNLPGPSAETLLATSAPDPNSALSAPMPSAAAVNSQQFLLKWFDDGQLKVDIGLQQSLMKKDKSLYQTYMEAMRTKPESISGAAFNSQFWSTRINLLRAHAIEINQKKGAYNVLSTVKPRTVDGELKLNISVEQVQLILAQHPLVRRIYNENVPKLSESDFWSRFFLSRLSKSLRGERVTDSDRSDPLFDKYSVSDNTSSTSKISILAVPYIINLEANEENQGGFRTGNAKDIEMRHRTNMSIAKTLNSMSDKIMANVSPTDSAKYDEGRRNDIYGGELSLRDLKADYQENRIMLHIKGLHRNLHQQDLASFSRALNVGRQDPEEVLARVKKTVLSIADEGGNEAALHGAIDFDDDIDNGDERLEGLRVGSRAATTDAEGEVMKDIRQQRAQELGHLDDTSSPMGLPPPMTEKCSLTHATTIEFLQQFWNAFLSGDSDRAAELQYLAESLKCSEARIAAAAQEADAERDALIRKRKQEIRHHFEQTGKKIKWKSQMIGGGHEAVDTIMRPVLSALTQAQDNYSKALLADGLQSTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LC26</accession>
    <name>A0A367LC26_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_4582</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000008">
        <property type="protein sequence ID" value="RCI11983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LC26"/>
    <dbReference type="STRING" id="1330021.A0A367LC26"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF7">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="75"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI11983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="284" mass="31763" checksum="F5F3CD0501B07F46" modified="2018-11-07" version="1">MLRSRTTTSNSNRSFSSKSNSKTKVSKSNSSFTKDGSGVSKKRHEHRSRRLAAVEMAFKSDDVTSVSNGEPPTSAIVTLVVGSEQRLFAAHEAVLCSSPFFLSLLQSAYPPQQATKRVSLPDEQPDIFSSVLEFLYKGDYFPRLKHNKRRNSWELECASDEERTSVESTVYHHGVDGELLKDTVIYCAAVRYGLDELKRLALRKQGFQSGIQCSTILASARYAYANTPDTDSKLRAHYLALIIRSRATFKRSGTMQLEMYNGGTQLFFDLFVAMTNHLDDVSSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCP4</accession>
    <name>A0A367LCP4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_0908</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCP4"/>
    <dbReference type="STRING" id="1330021.A0A367LCP4"/>
    <dbReference type="OrthoDB" id="422005at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000006">
        <property type="entry name" value="Cold shock protein CspC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012156">
        <property type="entry name" value="Cold_shock_CspA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050181">
        <property type="entry name" value="Cold_shock_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11544">
        <property type="entry name" value="COLD SHOCK DOMAIN CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002599">
        <property type="entry name" value="Cold_shock_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="3">
        <location>
            <begin position="3"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI12199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="69" mass="7359" checksum="34C0B20D075E0291" modified="2018-11-07" version="1">MAPLKGHVKWFSETKGFGFIAKDDGGADVFVHFAVIEGDGFKTLDEGQAVEFDVAEGSLGLSASRVKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCU1</accession>
    <name>A0A367LCU1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HIG1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_0252</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCU1"/>
    <dbReference type="STRING" id="1330021.A0A367LCU1"/>
    <dbReference type="OrthoDB" id="1915122at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007667">
        <property type="entry name" value="Hypoxia_induced_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040153">
        <property type="entry name" value="Rcf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28018">
        <property type="entry name" value="RESPIRATORY SUPERCOMPLEX FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28018:SF3">
        <property type="entry name" value="RESPIRATORY SUPERCOMPLEX FACTOR 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04588">
        <property type="entry name" value="HIG_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51503">
        <property type="entry name" value="HIG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="HIG1" evidence="6">
        <location>
            <begin position="88"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI12240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="244" mass="27174" checksum="D5E86E2297A09C03" modified="2018-11-07" version="1">MKVLSKEEEEAHFSTVLHGGLVGGVAGLGIGLGGVLFASRRYPAFRSLTLPFRAFLVTSSTTFGAIVNADRHSTIFQRSQHADSDYRDLSQRAADMIRENESSYQRFMAWGREHRYSIVFASWVVGMGAALAAVGRAPMTTPQKVVQARVYAQALTLAVLLVSAVFEMSDAQKGSGRWETVLVVDPNDPEHKHLIEKKVHREEYEGQDLWKDMVEAEERRLKAEETRLKAEEGHVKAKDANATK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDB7</accession>
    <name>A0A367LDB7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Succinate dehydrogenase [ubiquinone] cytochrome b small subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_0457</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Mitochondrion inner membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CybS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDB7"/>
    <dbReference type="STRING" id="1330021.A0A367LDB7"/>
    <dbReference type="OrthoDB" id="18577at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098796">
        <property type="term" value="C:membrane protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03496">
        <property type="entry name" value="SQR_TypeC_CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1300.10:FF:000007">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] cytochrome b small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007992">
        <property type="entry name" value="CybS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13337:SF2">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] CYTOCHROME B SMALL SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05328">
        <property type="entry name" value="CybS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="binding site" description="axial binding residue" evidence="11">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <note>ligand shared with SDHC</note>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>a ubiquinone</name>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <note>ligand shared with IP/SDHB</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR607992-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI12415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="164" mass="17884" checksum="DFF9F02E82D1DA40" modified="2018-11-07" version="1">MASITRTCLLRTSRRSVLTKPLALATLHSSARRSAILPPGPQRIEGGVNEAAPVPEPNATHGSYHWTFERLLAAGLVPLTIAPFASGSLNPAMDAILCSAVLIHSHMGFQQVIIDYVPKKRYPGLRKVCWWGLNLATLTVGVGLYEFETNDVGVVETIKRIWKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDD3</accession>
    <name>A0A367LDD3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_1141</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDD3"/>
    <dbReference type="OrthoDB" id="4931002at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="9"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI12443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="375" mass="42653" checksum="DF7513D87C207415" modified="2018-11-07" version="1">MLRYSFALRSRSGLQRQQQQQRQQRQQTQKDYLITGCQEGGRTRGPRQQTSRPSSSSFLRQGSQRPIPRSFFSTFTDTATATANALVATVPLLLLLSLSNALFGPIFSAAFFVLWSSILFFPPSSSYGRPYDLQRRQEQGQDQGQDQDQDQDQERDRQRNTGTSQEQQSQQPSRQPLQQEQQQHTNVPTAVPYLRPPQSLPSSSGIQQFLDQFEERVLDRRVDWLPFFVAPPCLRQIQVLTEDLPWPAAKTALLRYYGAFDQIRTVGFYDKLRRHEARRPKTKDTIDWLEKHAFLCRKVGPGPGPGPGPGPGPGPDESTEHSYGLFQALPKEIQVQLYDKLERPSSSPYGILFSTAYFLTQIQLEDDSFSGFSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDD7</accession>
    <name>A0A367LDD7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0986</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDD7"/>
    <dbReference type="OrthoDB" id="4611802at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016669716" evidence="1">
        <location>
            <begin position="17"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="71" mass="7730" checksum="7460B943125FFD7F" modified="2018-11-07" version="1">MKFLALTMAALASVAAAGWECKPATYACTFENGKYGWKVCNTSGKWVVGGHCRDTQYCELNEDNGSPYCLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDU5</accession>
    <name>A0A367LDU5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDU5"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="123" mass="14107" checksum="C7C46F573544DB05" modified="2018-11-07" version="1" fragment="single">PLTIYIKDDYKDSTNILFCKSIRALEPLNYKLADLFPPTRTVASLIERTRSAIPQEEASNIVDCNKEVFNYKEAAFNKVFNYEDAIYISPPRQTSSKLSDPGAKTPSPREYDFYELRGQQSKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEK4</accession>
    <name>A0A367LEK4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">MADS-box MEF2 type transcription factor MIG1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_0704</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Transcription factor acting downstream of the MPS1 MAP kinase (MAPK) cascade during conidiation and plant infection. Required for overcoming plant defense responses and the differentiation of secondary infectious hyphae in live plant cells.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Interacts with MAPK MPS1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MEF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEK4"/>
    <dbReference type="STRING" id="1330021.A0A367LEK4"/>
    <dbReference type="OrthoDB" id="1898716at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008301">
        <property type="term" value="F:DNA binding, bending"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00265">
        <property type="entry name" value="MADS_MEF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1810.10:FF:000013">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033896">
        <property type="entry name" value="MEF2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11945">
        <property type="entry name" value="MADS BOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11945:SF534">
        <property type="entry name" value="MYOCYTE-SPECIFIC ENHANCER FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="11">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="73"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="346"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="588"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="237"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="271"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="358"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="371"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="409"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="468"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="484"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="507"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="519"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="629"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00059910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00065556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI12855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="644" mass="67574" checksum="DB9AB1D14AF2C1F2" modified="2018-11-07" version="1">MGRRKIEIKAIKDDRNRSVTFLKRKGGLFKKAHELSVLCSVDVAVFIFGNNKKLYEYSSSDMRDLIQRYQTHGTINEHKGPADFNGGNDDDDDDDADGSPPRGSEVPMMAPQFAPGQHPPFSQILRHHAPSASPPIAHGVPYQPHQPHPRGPTPQPAMGSRPGSSNDIRRLGPGGPVSGSHAAHPGIAYMPTPPIYNPAGNQVGMMPSQHTGQYSYPQQPYVEERRPSAPPAYATQHPPPPPPPPPPPPSQAATARPEPSPPLHKHAPPRSTSLTSVSSTQLSGERRAQDAAPADIKAESSERPQQPLVNTDAAIKKMPQRKSHSIFTPIEENRSILYLHAVSFASDPQAAKSESGQPAAEAADAATTTALPPPPPPPPPPPPLKRSPSTDATPSRDDAAPASPRTKRSSTQSSLDKPHNSSMSSGPETAAPTPPSRANSNVGGPAPGGGSRPRGPRLTVQIPDGESEPGSGTGESNSPHNPAMTPTQAPQRSNSHSSVVLPPPSPSASTLLSAGATGPPNPFARPPPQQPVNGDTPASALPSRFLNEQLLPSPSSFYPDWNFRASDNNTLPSPLNFTTPVVGAGPSFLRDDGHVAGGGSAVGPGQAATHMSSGLGKRKSPDYGIGGHGEGHAPHSEPKRVKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEN4</accession>
    <name>A0A367LEN4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_0914</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEN4"/>
    <dbReference type="STRING" id="1330021.A0A367LEN4"/>
    <dbReference type="OrthoDB" id="7722975at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07407">
        <property type="entry name" value="MPP_YHR202W_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000043">
        <property type="entry name" value="Ser/Thr protein phosphatase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053828">
        <property type="entry name" value="Nucleosidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014485">
        <property type="entry name" value="Pesterase_C1039"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041823">
        <property type="entry name" value="YHR202W_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF43">
        <property type="entry name" value="SER_THR PROTEIN PHOSPHATASE FAMILY (AFU_ORTHOLOGUE AFUA_3G04160)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21953">
        <property type="entry name" value="NadN_nucleosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017316">
        <property type="entry name" value="Pesterase_C1039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016669743" description="Calcineurin-like phosphoesterase domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="3">
        <location>
            <begin position="38"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Putative 5'-nucleotidase C-terminal" evidence="4">
        <location>
            <begin position="376"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="551"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI12885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="627" mass="68709" checksum="30EBB329C436D052" modified="2018-11-07" version="1">MALLLSLMGLASPALTSQPGAAPPVPAPMRDLPWGQLNFLHTTDTHGWLGGHPAEPQYAADWGDYVSFAHHLRRRADESGSDLVVVDTGDRVEGNGLYDASEPKGRYLLDVLASQHLDLACIGNHELYRRQTVEREHNLTVPRFGDAYVASNVDYIDPATGEASPLASRYRKFKTKNLGLNIVAFGFLFDFVGNANNSRVHTVADTISQPWFQKAMHEKPDLFLVAAHIGLRMPELRAIFTALRKQNWHIPVVFFGGHAHVRDAVRFDSLSIAMASGRYLETIGWMSIDGIRPKPPPAPLSSSSSPLSPPPPSTAIATSLTFNRKYIDSNLYGMYYHTGLNATSFPTDQGLRASEAVAAARKALDLDHRFGCAPHDLWTTRAPYPGNGSVYSWLENEVLPDVVVNSSRSDRPRLAFINTGGIRFDIFKGPFTRDSLLAVSPFKNHFLFVPDVPYAIARKLLAILNSGGVVGVGDRSKAPLVVAEFQDEINEDDVVRPELRRRGSSSQKPDPSLLPGYTTKDDLGSDGDDTVRSQVESHRPPNCIQSRIGFPSSSPLSSSASSSSSSSSSPLPEKVDVVFIDFLRPWLIAALKFAGGDYSDADVGPYLDVTFTCALEEWVVRHWLGDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEY9</accession>
    <name>A0A367LEY9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable cytosolic iron-sulfur protein assembly protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CIA1</name>
        <name evidence="5" type="ORF">L249_0014</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat CIA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEY9"/>
    <dbReference type="STRING" id="1330021.A0A367LEY9"/>
    <dbReference type="OrthoDB" id="284782at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03037">
        <property type="entry name" value="ciao1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028608">
        <property type="entry name" value="CIAO1/Cia1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR PROTEIN ASSEMBLY PROTEIN CIAO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920">
        <property type="entry name" value="WD40 PROTEIN CIAO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="131"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI12994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="447" mass="48439" checksum="56B645BE69BFD704" modified="2018-11-07" version="1">MPPPTPSAMAIVPLSHLLPDLHERAWASVPHPSLPLLATAHAKGVTVFSLVTLTSHSTLTGGHTRSVRSVSWEPGLPSQKLCLVTGSFDSNAGLWRFDADGGPGLETEVAAEAGDEGRSVGDQDWVFTVLLEGHGSEIKSCAFSPSGAYLATCSRDKSVWIWEDVGRSSGAEDEWQTQAILEEHEGDVKAVAWCPDVPGRSARRRYSPDVLASASYDNTARIWREDADAEFVCVSVLEGHEGTVWGVQWESNTTPHNRFPRLLTFSSDATARIWTLEEDISDDHVEAEEFSIGSGLGRIPNTMRPSLRETWKCTAILPKVHDGDIYAAAWSGQSGLIASAGSDGVIALYREASPPQAPGVITTAVDVSHSLSSQPSSLPSTTSWDLLATFPNAHGPYEINHITWCRRYDEAVGDRRGEEEMLVTTGDDGLVRTWTVTLKQVEPPMST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LF38</accession>
    <name>A0A367LF38_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ArsA/GET3 Anion-transporting ATPase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_0994</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the arsA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LF38"/>
    <dbReference type="STRING" id="1330021.A0A367LF38"/>
    <dbReference type="OrthoDB" id="1770at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02035">
        <property type="entry name" value="ArsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000235">
        <property type="entry name" value="ATPase ASNA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03112">
        <property type="entry name" value="Asna1_Get3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="ArsA/GET3_ATPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027542">
        <property type="entry name" value="ATPase_ArsA/GET3_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00345">
        <property type="entry name" value="GET3_arsA_TRC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="ARSENICAL PUMP-DRIVING ATPASE ARSENITE-TRANSLOCATING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803:SF3">
        <property type="entry name" value="ATPASE GET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <keyword evidence="7 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="ArsA/GET3 Anion-transporting ATPase-like" evidence="10">
        <location>
            <begin position="26"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="active site" evidence="9">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="33"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="273"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI13035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="342" mass="37515" checksum="E4DBA4CB67DBA38E" modified="2018-11-07" version="1">MSTAIVSADEALEPTLKSLLDQRSLRWIFVGGKGGVGKTTTSCSLAIQLARVRRSVLLISTDPAHNLSDAFSQKFGKDARLVNGFDNLSAMEIDPNGSMQDLLAGQSDNNPAAGDDMTAGLGGMMQDLAFAIPGIDEAMSFAEVLKQVKSLSYETIIFDTAPTGHTLRFLQFPSVLEKALAKVSQLSSQYGPLLNGFLGSGGTLPNGQSLDDMMAKLESLRETIADVNTQFKDAHLTTFVCVCIAEFLSLYETERMIQELAGYGIDSHCIVVNQLLFPKKASDCEQCNARRKMQTKYLDQYEELYAEDFNVVKMPLLVDEVRGKEKLEKFSELLIQPYVPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFG2</accession>
    <name>A0A367LFG2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Mur ligase central domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_1150</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the folylpolyglutamate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFG2"/>
    <dbReference type="STRING" id="1330021.A0A367LFG2"/>
    <dbReference type="OrthoDB" id="5212574at2759"/>
    <dbReference type="UniPathway" id="UPA00850"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008841">
        <property type="term" value="F:dihydrofolate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004326">
        <property type="term" value="F:tetrahydrofolylpolyglutamate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.20">
        <property type="entry name" value="Mur ligase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.10">
        <property type="entry name" value="Mur-like, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000641">
        <property type="entry name" value="CbxX/CfxQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001645">
        <property type="entry name" value="Folylpolyglutamate_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018109">
        <property type="entry name" value="Folylpolyglutamate_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036565">
        <property type="entry name" value="Mur-like_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036615">
        <property type="entry name" value="Mur_ligase_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013221">
        <property type="entry name" value="Mur_ligase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01499">
        <property type="entry name" value="folC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136:SF0">
        <property type="entry name" value="DIHYDROFOLATE SYNTHETASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11136">
        <property type="entry name" value="FOLYLPOLYGLUTAMATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08245">
        <property type="entry name" value="Mur_ligase_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00819">
        <property type="entry name" value="CBXCFQXSUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53623">
        <property type="entry name" value="MurD-like peptide ligases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53244">
        <property type="entry name" value="MurD-like peptide ligases, peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01011">
        <property type="entry name" value="FOLYLPOLYGLU_SYNT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mur ligase central" evidence="9">
        <location>
            <begin position="54"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase AAA-type core" evidence="8">
        <location>
            <begin position="889"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="732"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="732"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="761"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="784"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI13166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1021" mass="113843" checksum="2CAD5EDA4E8C2211" modified="2018-11-07" version="1">MPPTARDIKRVLARIRAVLPVEKQFDAARRNIRLGLERISRIIPARQDWIGIHVAGTNGKGSICMLLAGMLRRAGLSHGVFVSPAMPEPHNGVLINGRYANKRMYELETNDVCASYRRAASGWKFSLGEDPGDLTPFELQTATAFRVFDKMHVKYGIVEVGMGGATDATNAMREKAVTIISRIGLDHQEYLGGTIEAIAKVKAGIMRKSVPCIVDDTNPDSVLAVLTEHANEVGTQIWLSSKAAPLLKNLDRERFQLRPYEERNLMCALLAFQGLFPNLKLDVNHLVPSQPFLPGRKERVSVTGLTGGLRKNPLFVDGAHNLLGVEALAAHVNEGGMRKGEEPLTWVMGMSSSTTKPFAQIIETLLRPQDNLAFAEYEPQANDPLPAPADLGRDIGRALLNDASQIYDGDASISAAVQWACAKAGEGPVVVTGSLYMIRELYKVDGVEPQCKIGTMRPGPSQLWHYTRQAMQRVLTDEEEREFKRARQHNWVSPRVSPVFRDVRDGGKPRTEVVPEWVRDLHRTAAHHKKQADGYGAAIASIEKDMGEGGKDSPLGQTIRELKVKQGEHRRMYDKAILDVRQRVSNKRFLSYTQIFGRRKKRREGPVTALLRKYKLLDRVKTLEAMPKKKVKRKTEKMGAAKAPNMNDGVSAEEQLRQRRDLMQWRPTETKAEKVKSPKTGVLLKMSLEKKLSERRMPKPRIAVEMKPEAKARAEDERKGAASVDALFAEKLSARREEKPTRATEAGNAHASFETVSVETSSDRMQPEQTRAEDAEMRMTAASFEEKMRERRMPEQRRAREAEAEAEAEARKTTVSSEERPSKRKTLEQRREAKAEAEPKPKPKPNPEAQKTLSPFDEEVNRRVAVEQRKAAKAEAKAEARKLAAPEKKTSTARKIGQVYYNLGILAGTTVVEISASDLTAQSVSQTGPKVRKMMDKALGQVLFIDEAYGLRGGGFAQGAVDELVGGMTKPRYQGKMIIILTGYVGNINKSRFPQTIRREWVALGKRALEMQSRGKTVDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFY9</accession>
    <name>A0A367LFY9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhamnogalacturonase A/B/Epimerase-like pectate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_0320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFY9"/>
    <dbReference type="STRING" id="1330021.A0A367LFY9"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23668">
        <property type="entry name" value="GH55_beta13glucanase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000049">
        <property type="entry name" value="Putative exo-beta-1,3-glucanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039279">
        <property type="entry name" value="QRT3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928:SF2">
        <property type="entry name" value="PECTATE LYASE SUPERFAMILY PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928">
        <property type="entry name" value="POLYGALACTURONASE QRT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016753656" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="2">
        <location>
            <begin position="72"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="2">
        <location>
            <begin position="418"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI13331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="779" mass="83011" checksum="049D24E7F4BC7CC8" modified="2018-11-07" version="1">MFQLASTVALFLAVAVATPTFGGEVDLSRRHATAFWYPNMDHAGPYRGYAPDVDGAAEYQVYRAVRPADGQGIQEAINDDNGQRRHGQWLASQPRVVYIPPGTYELNKTLYMNTDTILMGDAIDPPVLKAAAGFSGTPILVSGTLPDLLADEAAESLTFVPIAQDPATGELGERSFAVGLKNLVLDTTNIPGGNGFTALYWGVAQGAQLQNMRIVMATPKGDNGHSGIHLGRGSTLGLSDVRVEYGLNGIWHDGHQQAAYKNIQFYKNKVGMLISAGNTITIMGSTFDSCGAGVRNTGGTPWIAVVDCTSINSGVSFETTCQPSFLLENFVKDTDSDMARGPQGTLLGPSRHVDRFVYGKAAGRGDPVYGPSTASSPRPPILAPGGKYPVIPAPTYADKAASDFINVKDPEQNGGNKVHGDDTADDAAALNAVLKYAAKEGRIAYFPFGNYRVESTVVIPPGSRIVGEAWATISGSGAYFKDETKPRPVVSVGEAGDVGVAQMQDLRFTVADVLPGAIIVQFNMAGRLPGDVALWNSLITVGGTRGASKLGEKCRDPSKECKAALLGLHFTRDSSAYVENVWNWVADHVTEDFDGGTSIAAKAGCLVESTKATWLHALGSEHWWLYQLNLRRARNVMVSLLQAETNYDQGANAKQLAPSPWKPDVSAWGDPDFGSCAEDDGRCRMGFATVVEGGSDVYSYGSAAWAFFSGPGYQGCGGQTCQGTMHWIKQTPKNLQVFGLCSKDADAIVRLADGSKVLMRDGFEGSWPESGGLVGRYTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LG99</accession>
    <name>A0A367LG99_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">serine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Seryl-tRNA synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Seryl-tRNA(Ser) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_5509</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="2"/>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LG99"/>
    <dbReference type="STRING" id="1330021.A0A367LG99"/>
    <dbReference type="OrthoDB" id="10264585at2759"/>
    <dbReference type="UniPathway" id="UPA00906">
        <property type="reaction ID" value="UER00895"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000026">
        <property type="entry name" value="Seryl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="entry name" value="Serine-tRNA synthetase, tRNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="13">
        <location>
            <begin position="189"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="66"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="289"/>
            <end position="291"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="305"/>
            <end position="308"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="376"/>
            <end position="379"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for serine binding" evidence="10">
        <location>
            <position position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI13445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="476" mass="54279" checksum="9DF1402D732E1E14" modified="2018-11-07" version="1">MLDVNDFIADRGGDPEKIRESQRRRYANVDVVDEVIALFEDHRKTNYSATQISSKINEVQKQIGTRKKAKESIDDLLAHKQDLEKEKKSMADSAAKKEALLKSKLKTIGNIVHHSVPVSNDEDNNAVLRKWAPQDVSVEKRNCLSHHEVLLRLDGYDPDRGVKIVGHRGYFLRQWGVFLNQALINYGLEFLSQRGYISLQTPQFMLKDYMSRTAQLEAFDEELYKVLDGEDKNDKYLIATSEQPISAFHAEEWLIAKDLPIKSVKPASSRRCPILTLVLRYAGYSTCYRREAGSHGRDAWGIYRVHQFEKIEQFLLTDPAMSWEALDEMIATSEEFYKSLGLPYQVVAIVTGALNNAAAKKLDLEAWFPYQGEYKELVSCSNCTDYQSRALEIRFGAKSQTDTKKRYVHCLNATLCATTRTLCCILENYQTEDGLNVPEPLRKYLPGAPDFIHFTKELPKESTSLKSSSRIGKGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGD6</accession>
    <name>A0A367LGD6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5651</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGD6"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI13457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="45" mass="5287" checksum="20808573A88914FA" modified="2018-11-07" version="1">MTYRYVRVLQVGTLKYLEKLSRDSSSSFLLRNHLPDSLTLYPLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LH24</accession>
    <name>A0A367LH24_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Cell division control protein 42 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_7977</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LH24"/>
    <dbReference type="STRING" id="1330021.A0A367LH24"/>
    <dbReference type="OrthoDB" id="8830751at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01874">
        <property type="entry name" value="Cdc42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000236">
        <property type="entry name" value="Cell division control protein 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037874">
        <property type="entry name" value="Cdc42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003578">
        <property type="entry name" value="Small_GTPase_Rho"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24072">
        <property type="entry name" value="RHO FAMILY GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI13687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="261" mass="29539" checksum="3889F247A20E4508" modified="2018-11-07" version="1">MAVVATIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGDEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVTSPASFENVREKWFPEVHHHCPGVPCLIVGTQVDLRDDPSVRDKLARQKMAPVRKEDGERMAKDLGAIKYVECSALTQYKLKDVFDEVSSSFHSNPWSRREADKFTARLLLLRWSRRCRRRSHISASSYNLISTMPTTSDSIRITFVSAWMAAWVRETEKLAGGRTSKVNSWRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHA3</accession>
    <name>A0A367LHA3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_8231</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHA3"/>
    <dbReference type="STRING" id="1330021.A0A367LHA3"/>
    <dbReference type="OrthoDB" id="410044at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050907">
        <property type="entry name" value="SRSF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23147">
        <property type="entry name" value="SERINE/ARGININE RICH SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="342"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="414"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="649"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="414"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="449"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="531"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="552"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI13767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="682" mass="75590" checksum="09AC429285CCCB32" modified="2018-11-07" version="1">MAPPAMRLPEKKPSLGHGLELDAMRKASSCEPFNKDGLNSSDDENNPGGAYCETASDTFLPVSKIRTRAQFRKPYSDDGAPATRSTNFLVGSTDDDDVFTVGSNDDFTQVSSPGGGADVAVYQDLRDKVDPQTMYAGSSCMFVANLPQQFNDRRLEEEVTKNFSQFGIVFVKIKRDSRGMPFAFCQYTVREQLINGHLTDGADTCQNDEDARSALRLGRGIMIFERPCRTEMARAHSSFIVFKVSGQRIRLHEARDLLRRLGEISKTEYLNDALRALSQLPQAVVVTYKMYDAKRDPVKAFELDPVYRVQVYDPKMLAAKDNFQMGSPREGSFLRRYDKDRRSAYVGNLPPTMTRDVLKSLASSCGEVVDVQLHSKDVPGGSGCKTCFGFIEFNRPDAPDELVEALNNTQIDGHRVRAERKQSRGVETPRYGPSPARYANGRGRVGSFELEKPSESHFDTPLENSGRQSRRKLYASSSFTPGRNRLSRPSVLDSNASPVRGIFEPQEAMQRASARSPQVNPLTAHGPSAKKSVEFDLDRRRHSDDSAEANIKPTTPKTSGASTASSARKQPSFRESEAVPAAQATMPQWLPSYGPFGYPYMGTPITPQANPNLMFPGYMQHPMYHTMCDMYGNIMVSPTHMMPAFNATPPIMSETPARSDNGAEGAKSDMSESKDEDDEPNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHF5</accession>
    <name>A0A367LHF5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA-splicing endonuclease subunit Sen15 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_7909</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEN15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHF5"/>
    <dbReference type="STRING" id="1330021.A0A367LHF5"/>
    <dbReference type="OrthoDB" id="10002170at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000214">
        <property type="term" value="C:tRNA-intron endonuclease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000379">
        <property type="term" value="P:tRNA-type intron splice site recognition and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042777">
        <property type="entry name" value="Sen15_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018593">
        <property type="entry name" value="tRNA-endonuc_su_Sen15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28518">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28518:SF1">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09631">
        <property type="entry name" value="Sen15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA-splicing endonuclease subunit Sen15" evidence="3">
        <location>
            <begin position="21"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI13855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="143" mass="16446" checksum="4449A86CCB89956C" modified="2018-11-07" version="1">MNGTSHLDIHRRTCESVARTVLFDLEHQHDWTGLEIIPGSELARFLIRGLPPKRLYLHPDDQVAALALERRAGESLCHEPQYEWVLPVHLAEKWSLAGFSTVFDLIDMDVHSQAKRVLLAILHNDSTVVYYFMHQGIVKPRQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHJ3</accession>
    <name>A0A367LHJ3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHJ3"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="89" mass="9095" checksum="C057106DEA158CFF" modified="2018-11-07" version="1">MLDHASTCQGMTTLISFDPGAKSERGGNGDGRGVRSGGLVALLLTLCDGDSSRHTSGEAGVEGWRGGREGASITIGREHGQKPVMQASP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHU0</accession>
    <name>A0A367LHU0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fork-head domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_7911</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHU0"/>
    <dbReference type="STRING" id="1330021.A0A367LHU0"/>
    <dbReference type="OrthoDB" id="5954824at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00059">
        <property type="entry name" value="FH_FOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22701">
        <property type="entry name" value="FHA_FKH1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000030">
        <property type="entry name" value="Forkhead box protein K2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001766">
        <property type="entry name" value="Fork_head_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018122">
        <property type="entry name" value="TF_fork_head_CS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030456">
        <property type="entry name" value="TF_fork_head_CS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881">
        <property type="entry name" value="CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45881:SF1">
        <property type="entry name" value="FORK HEAD PROTEIN HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00250">
        <property type="entry name" value="Forkhead"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00053">
        <property type="entry name" value="FORKHEAD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00339">
        <property type="entry name" value="FH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00657">
        <property type="entry name" value="FORK_HEAD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00658">
        <property type="entry name" value="FORK_HEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50039">
        <property type="entry name" value="FORK_HEAD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FHA" evidence="8">
        <location>
            <begin position="125"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Fork-head" evidence="9">
        <location>
            <begin position="307"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Fork-head" evidence="6">
        <location>
            <begin position="307"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="235"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="400"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="511"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="237"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="408"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="526"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="572"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="603"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI13988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="642" mass="69418" checksum="B2A57FDE71E74FFB" modified="2018-11-07" version="1">MPLSAKRAQRARRDLRYKDRAVDADADAEPEPEPDQSSSPSRPTKRRKRAPTPDRLSSTALDPEEKLGTDDDQTVSQVTQHLKSQPVQAAKDHSNAIYEANKDNVKAYAKVAAQDWTFYITKLSVSIGRAPELPQADDGHVVDHAQVHIDLGPSKMVSRDHAAITFDPKNQQWLLEVKGRNGAMVDGQILKPRESCPLISGQVIEIANVEMMFVLPSNISPLHIHPTFLKRCGLASEPSSQPAVTPHSQPYLAPTASTPPAYTRPGTPPSVQRLATRETTSATASTPAVVVGAGGVDLSHDDFHHIKPQYSYAQMITQAIINAPDGKLNLNGIYTFITKNYSYYRHQQAAGWQNSIRHNLSLNKAFDKVARSTDEPGKGMKWQIVADVKEEMIRNAYKLGRGGHRGSSAPSSPNQLNYVTHGPKDMASREPLSIRKHQGSPLASPPPRLSGPMAHSTPDRTGGRRMAILTADGSPLPRQNKGASNSSLTAFSVHSPTLTSSFLQEEGASFVTPAPPKIHPRLAPPSTAQRPSQHMPTSSPAPFWKYAEIGSTPLRPSAQYEASPSKVAGRISSNSSSPPGVGKSPPSSPSRPQKSGAPQERVETEELVEEQGFDLTKGFQSIGSYHAPVGRGVRVANALAGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHW6</accession>
    <name>A0A367LHW6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8235</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHW6"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="253" mass="27470" checksum="6191E1A218F5565D" modified="2018-11-07" version="1">MTHRRQLDPEIGQGDLDEKTPSWTVQGPGSQATGMSICDGQRESRPCACAEQQKLSRQTDSLAASKHGEKATIRAGQSKNIVSALLCGIPDPSRGYLVAFLFSGAAAIDWLVGLIRCVHLRRHTAYDKGVPVQFSLPPLFRAPAEGIVARVSSPLTRIRTQLICTYYEAVPSLPKSASIANIIYFDHPVSTLVPTDNHIPLVRMESLASNSVWLRIHPLDASLDEQLCSISDGRKGTQSLGSMILLPVSRNAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-05-03" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LI21</accession>
    <name>A0A367LI21_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8016</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI14074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LI21"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="101" mass="13446" checksum="60033260832E1AFB" modified="2018-11-07" version="1">MCELYFHLYEGCSHPRFWNWIHCPYNRETECINYRYRSYKHPGKCEDCRQQEHDERVRQRHEDERRRRQEREEREERERRQREYERLMSEQRRRQRQRRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LI40</accession>
    <name>A0A367LI40_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_8192</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI14079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LI40"/>
    <dbReference type="STRING" id="1330021.A0A367LI40"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF0">
        <property type="entry name" value="CELL CYCLE SERINE_THREONINE-PROTEIN KINASE CDC5_MSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="352"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="267"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI14079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="710" mass="77360" checksum="319C02BF8E199240" modified="2018-11-07" version="1">MAAMKPDSATTTRFSAEPASSTKTAAIAIAVRAPLTRPPPPSSYPDSYASSPYSLTNPEEGADDSADSLAEPVTPVSCDRCSQDFTTDVDRSVSRSPTSTPKQPAPPLISHNSGTPPPGRLSGSDTSPPTPQSRRSARGHASRLRRTVSNIFRRSNSAEKVREFATNDAPPPLPTSHPTSDPYVGPNFLIRSSASSTNQSYSPPSPLSPVSPVSPASPPPMTPTHASAVGSQSFPSSEDFQKKGRAATGFSIRGRAVNFGGAKGRGSRQPSPSRRASSFDGLKRAATPSSTPPTPTENDNRTYPPERLPWPLPPDAGTGVKARRMSLSLPDDFYIDVADLQSEYEYQHKILGRHGKHLGKGAASRVTLMVRKGCPGELYAVKEFRGKSHRESQAEYEKKIKSEFSIGKSLHHPNIVETVRLCTNHHRWNHVMEYCSEGDLFSLVQKGFLKGDDKRKDRQCLFKQLVQGVGYLHSNGIAHRDIKLENLLLTKDSKLKIADFGVSEVFSGTHPGLREAGGQCGRNMGEVRLCSPGICGSEPYIAPEVLAKKQSYDPRALDVWSSAIVMIYLTFGGAIWSRAEGGQPHYDKLVHGWEAWNRRHPEEGAAITEDDYPKCLALDVGVNPPALRRLLLQMLNPDASRRIGMADVLSNRWMRNVECCQLESYDEQAQAIDATKKEFCGGKKIFCHNHLPSKMATSHSLGKMPGQAGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIJ7</accession>
    <name>A0A367LIJ7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Galactokinase</fullName>
            <ecNumber evidence="3">2.7.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Galactose kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">L249_5929</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>alpha-D-galactose + ATP = alpha-D-galactose 1-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13553"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28061"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58336"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:13554"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GHMP kinase family. GalK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.6" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIJ7"/>
    <dbReference type="STRING" id="1330021.A0A367LIJ7"/>
    <dbReference type="OrthoDB" id="187738at2759"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004335">
        <property type="term" value="F:galactokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000411">
        <property type="term" value="P:positive regulation of transcription by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1440.340:FF:000003">
        <property type="entry name" value="GAL1p Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000056">
        <property type="entry name" value="GAL1p Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000705">
        <property type="entry name" value="Galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019741">
        <property type="entry name" value="Galactokinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019539">
        <property type="entry name" value="GalKase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006206">
        <property type="entry name" value="Mevalonate/galactokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00131">
        <property type="entry name" value="gal_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457:SF7">
        <property type="entry name" value="GALACTOKINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10457">
        <property type="entry name" value="MEVALONATE KINASE/GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10509">
        <property type="entry name" value="GalKase_gal_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000530">
        <property type="entry name" value="Galactokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00473">
        <property type="entry name" value="GALCTOKINASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00106">
        <property type="entry name" value="GALACTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="9" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="11" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Galactokinase N-terminal" evidence="18">
        <location>
            <begin position="33"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="16">
        <location>
            <begin position="143"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="17">
        <location>
            <begin position="418"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF10509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RCI14230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="525" mass="55952" checksum="F5DAB3153331BF61" modified="2018-11-07" version="1">MSGPVPVAGALADIYPLPALATEAPRWDQLLRRFRDLYGRSASFVARSPGRVNIIGEHIDYSLYSVLPMAVTADAIVAVATRPAAADAAARIRLANVHEAKFPSREFLISVDGDVDIDASSLEWSNYFKSGLRGALGLLRGRDAPICDMDVLVDGNVPVGGGLSSSAALVSASALAVLVANKAVPVDKKQLTELAVVSERAVGVNSGGMDQAASVFSEQGAALFVSFSPTLEARPVSFPPTRPELCFVVAQSFVTSNKHVTGPIHYNLRVVEVTLAAAYLNAVLNPPGTELAADAGPLGISLHGFHDTFFLHHGGSDYAAAKSLSKEEELKNLVAMTEGALTQEEGYTKEEIAKVLNLSVAELEKRYLSSFPVQAERFKLRQRALHVFTEALRVIQFLTLLERPVGSGASDTSEYNGKLGRLMNETQASCRELYECSCPELDRICEVARRAGAYGSRLTGAGWGGCSVHLVAVDGVAAVKEALEREYYAGRELTDEQKDAAVVVSRPGGGSAVYQVEEGKAVELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIS0</accession>
    <name>A0A367LIS0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">Defect at low temperature protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">DLT1</name>
        <name evidence="9" type="ORF">L249_6081</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 7">Required for growth under high-pressure and low-temperature conditions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DLT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIS0"/>
    <dbReference type="STRING" id="1330021.A0A367LIS0"/>
    <dbReference type="OrthoDB" id="4096362at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038869">
        <property type="entry name" value="DLT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40021">
        <property type="entry name" value="DEFECT AT LOW TEMPERATURE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40021:SF1">
        <property type="entry name" value="DEFECT AT LOW TEMPERATURE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="289"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="289"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="310"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI14300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="351" mass="38681" checksum="DA9DAB7217EA54F8" modified="2018-11-07" version="1">MPRWRRVVSSIAYGLVYLWFLVILGALLLVTPGDIIALSLHHRQIYNVWIVIVAFVVTVIIVCVVYVMRIYVNKTALASIPKAWVPIEKGDVEDAVCKMIAADQDRSAIIAYEAHPRVEMRDREPQPHDGSAPLPWRLGPGATQMTAEALGIVLLPNHAVWGEFEHGGWASPYSADMADLEYDTVISELPNLIEGKALTLAPQDDAEAPQLLQRRSSMDLRAYMGHLADLGVVTAGKTTSDFLSRYERARFSTRPLVNAQFRELMHLFAEVLRAMRPFDAAAFYSPTTEGFSTPLSTESPSNGEAKGRTGSASEASSSEYGSVVRLASPEDAEALPYMLYLANSGRWGEGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJN3</accession>
    <name>A0A367LJN3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peroxisomal membrane protein PEX17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_6410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJN3"/>
    <dbReference type="STRING" id="1330021.A0A367LJN3"/>
    <dbReference type="OrthoDB" id="2357318at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055334">
        <property type="entry name" value="PEX8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39214">
        <property type="entry name" value="MICROBODY (PEROXISOME) BIOGENESIS PROTEIN PEROXIN 8 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39214:SF1">
        <property type="entry name" value="MICROBODY (PEROXISOME) BIOGENESIS PROTEIN PEROXIN 8 (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26001">
        <property type="entry name" value="Pex8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="673" mass="73497" checksum="0A3E58C3DB6ABBF5" modified="2018-11-07" version="1">MPADRLLNTLLQRYRDVHDATTTDQIIGTTAHLLGRLSNPLNLGLLTSQLLTAPAVWHRHDGSPTAMRIIGIYKTAATNVRDAVPGVRRMGCDEWARAVVRGADDRSRPWRHLLVLTGVLVGMEAEDGSSLSWRLRRTLRQAVVTATNLALEHVVQDGHPAATSIITALIFAFPLLSEDDRCGIDCSALLPIAVSAMIGEDGFRHGGFLAAVGKDTSGGAPHLLHWPPDTPSHQLLKEMEGRSLMMNMGPLSKLAAFATQHARTSAAVLEAHHALFLFTGNVLDGWRKTALSGIDPDPEQGHLSIETRQTTWPLLCHVLRKLMFSSVALLQAIVSRSLVDPGMKADAMAPSVAAKSLHILRHLFFISSRDGNNGFEVYTFSYLTSIDVLSRYPDATHGFLQNLQQKSSAGLPSSHLERSLDLFYLNVAEHVPLVLSTESCETLIIQPAVSYLSHQGAMSPFMMDVFESAHSAILSVLSCPQLSSLTMEMAPFYLVKLFESFPRYISPRQFRVAFQTVMEIVSPPFPIAGLRPDLSETLLEMLRSMLTKASNKPLDSSSWLGTAQSREPSARVSEESALVMTLVDSLPFLPLHLMEEWLTIAAQLLGGIADPVLKAPVRQRFLDILVNGDLDVERAAIGVAWWGTRGGREAVLNGDVGDPAMMSGALGETQSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJU3</accession>
    <name>A0A367LJU3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_6784</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJU3"/>
    <dbReference type="STRING" id="1330021.A0A367LJU3"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05123">
        <property type="entry name" value="STKc_AGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000048">
        <property type="entry name" value="Protein kinase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000222">
        <property type="entry name" value="Serine/threonine-protein kinase psk1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045270">
        <property type="entry name" value="STKc_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="151"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="9">
        <location>
            <begin position="413"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="79"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI14670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="501" mass="55665" checksum="39AC786BDAB3C9D7" modified="2018-11-07" version="1">MISPVPHALTTVRGFQGTPVTSGDEDSDSGVCDTPRPRRGRHRLDDVVSANCSPVLRALPSPGVSGIAKLRMQMDPLSLDASSRSSSAVRVLDSRPHSRNRSEAGSDSSENRFEVKLETDFASESARNRAAFTEPLEGGLKPGRKMTCNDFEPLRCLGKGAYGTVILVKQRATGRLYAQKQFKKASLVVHKKLVEQTKTERQILESVNRHPFVVKLFYAFQDHEKLYLILEYGQGGELFTHLNTEKMFSETVAAFYMAEMLLAISHLHNDLGVVYRDLKPENCLLDADGHLLLTDFGLSKVAVEPSETCNSMLGTVEYMAPEVILGQRYGKAVDWWSFGALGYDLMTGHPPFRGQNNAKVQERIVKQKLALPYYLSADAKDLLTRLLRKDAKKRLGSQMPKDLETLRRHRFFRQIDWQRLEARDLEPPIQPMITDPELAENFAPEFTELALSPVTSSVDRESWAGGGSSSSNKDDDVFGGFSFVASSSLLESGAFPMANGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKD3</accession>
    <name>A0A367LKD3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKD3"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="153" mass="17239" checksum="9DB217F45BB354E3" modified="2018-11-07" version="1">MLKGSSMVRPAAGIRRREKLDVAGSGTGVVCLVTASANPPPPTTHIGYIYMYVRILILFGARERQTNKKKRLKQEGLSTKLEWIKGQVKERREKKRYGMSKATKQLGLFIYYAPHSMMTSQFVPLRASKWEAVPNQAGSACQVPACMRMCMRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKM7</accession>
    <name>A0A367LKM7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7071</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKM7"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="122" mass="13800" checksum="B21F52ADA7A911E5" modified="2018-11-07" version="1">MGIVIAARELGKMESNEVFCRAVEEEEGGEKLVESYLRQEEEDELRDGGFVRIEEELKAGEVIVGKPPSFIDKFLNNKGTSKGTVGRYDRYWYSASIAYSAPIDVQRADRCDDRCNESIRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLF1</accession>
    <name>A0A367LLF1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">quinol--cytochrome-c reductase</fullName>
            <ecNumber evidence="3">7.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">L249_6909</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </cofactor>
        <text evidence="17">Binds 1 heme c group covalently per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLF1"/>
    <dbReference type="STRING" id="1330021.A0A367LLF1"/>
    <dbReference type="OrthoDB" id="5925at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000002">
        <property type="entry name" value="Cytochrome c1, heme protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.100:FF:000003">
        <property type="entry name" value="Cytochrome c1, heme protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002326">
        <property type="entry name" value="Cyt_c1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021157">
        <property type="entry name" value="Cyt_c1_TM_anchor_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266">
        <property type="entry name" value="CYTOCHROME C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266:SF3">
        <property type="entry name" value="CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02167">
        <property type="entry name" value="Cytochrom_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00603">
        <property type="entry name" value="CYTOCHROMEC1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81496">
        <property type="entry name" value="Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 17 18" id="KW-0349">Heme</keyword>
    <keyword evidence="13 17 18" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 17 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome c" evidence="19">
        <location>
            <begin position="97"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR602326-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RCI15264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="321" mass="35428" checksum="037D1B179C634D2E" modified="2018-11-07" version="1">MLTRAGIRSARVLNGLRNGATALCKVRTASTSSGAASATARPNVAALASTTVAIGSIAWYYHMYGPVAHAMTPAEEGLHPTKYPWVHEQWFKTFDHQALRRGFQVYREVCASCHSLNRIPYRKLVGSVLTVDEAKTMAEENEYPSEPDDQGEIGMRPGKLADYIPAPYKNDEAARAANNGALPPDLSLIVKGRHGGCNYIFSLLTGYPEEPPAGAQVAPGMNFNPYFPGTGIGMARVLYDGLVDYEDGTPASSSQMAKDVVEFLNWAAEPEMDERKKMGMKVLVVTSVLWALSVWVKRYKWAWLKSRKIAYIPPEQTRVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLH6</accession>
    <name>A0A367LLH6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6862</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLH6"/>
    <dbReference type="STRING" id="1330021.A0A367LLH6"/>
    <dbReference type="OrthoDB" id="5591786at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014839">
        <property type="entry name" value="Crt10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08728">
        <property type="entry name" value="CRT10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="750" mass="84067" checksum="5171F03E640AEDCC" modified="2018-11-07" version="1">MEKPAVSSKRRPFQPVSVGLCHAQTANERFGCDVAKVVRRLERLAGFRRDTFSDGIPPGSESDKDGDDDLTNQLVPPLQRFRNNLTALSQLYNLYMVAYQARIFIYVPRGVPTQRVPCYPDLFLLPPRSEISRDRGDSVNENIESRHTINHLVVANFGDEEVVVTCHYDGDVVAYSTRRIAEWISRRPRHDWPDSDPPSVQTLVQNDSPLGGPGGENPKPTPFFHENVGQPAWALAVHQRSHLIAVSSNHCDVTVFAPALKSGIQGGRSELDDCPNCCSNRSGTCDNVESHVCQRMRNWRIIVSLGMHADLLPNVCFIDSPASGSASMICAIDLRGTVWLADIWKPFVPATAIPKGRIYNHQGWGLLVLPESSFLMVERLKELFGNDANIERRTRWKLDIGSTLRHVPDNPCMAWTNPVGFYGTVAWDPPYPFESSDDDSNVSEDSEMGQMAKEDQMAEEDQTAINHMIWEETTGQEIAEVIIADAENNGDDDDDDDDDDGFVDDGLDDDEVEEEEGAGAEGPKATMFYYPHLGLTMPMPRDKSKLLALLNGTLSTRCNKTDEVDERDELLEQHYMLRFFKEDAQLRKLTNNKTERGRELGTVCPEVIGRMVTESSNPLRDCIFTDTDRINMVAHVPELWLVVAASANGRVALLTPTRLRRHAESGGVLLRVGFRVEWILPRRSDEALKRTVLRPLHGMAVGPVQVSSCSGAEAGASRPRRFRLMLHYWNHDILTYELTRAEETGEVCVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLL5</accession>
    <name>A0A367LLL5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cytochrome c oxidase copper chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_6901</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COX17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLL5"/>
    <dbReference type="STRING" id="1330021.A0A367LLL5"/>
    <dbReference type="OrthoDB" id="1915887at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1130">
        <property type="entry name" value="CytochromE C oxidase copper chaperone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009069">
        <property type="entry name" value="Cys_alpha_HP_mot_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007745">
        <property type="entry name" value="Cyt_c_oxidase_Cu-chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16719">
        <property type="entry name" value="CYTOCHROME C OXIDASE COPPER CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16719:SF0">
        <property type="entry name" value="CYTOCHROME C OXIDASE COPPER CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05051">
        <property type="entry name" value="COX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47072">
        <property type="entry name" value="Cysteine alpha-hairpin motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 8" id="KW-0186">Copper</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR607745-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI15277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="77" mass="8507" checksum="20B8FDEA94B62CB1" modified="2018-11-07" version="1">MHDAKASPPKATTPAHHPSEEASSSSSTRPKPCCVCKEEKSKRDECMLFSTAKDPAAECSSFVDQYRSCMLRYGFTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLL6</accession>
    <name>A0A367LLL6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_6528</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">cis-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAPP small subunits family. TRAPPC4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLL6"/>
    <dbReference type="STRING" id="1330021.A0A367LLL6"/>
    <dbReference type="OrthoDB" id="246406at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14856">
        <property type="entry name" value="TRAPPC4_synbindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.70:FF:000007">
        <property type="entry name" value="Putative sybindin-like family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF15">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5 7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI15326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="188" mass="21577" checksum="779C27557DEDB5C4" modified="2018-11-07" version="1">MLREDSTVLGQAQRNLSRLRQRHLIHRLPPFRTVFALIIINKAGGLVFNKTFHEGGLNKISTNDYLVLAGTFHGVHAIAARLNPVKSPPPPPNPSSIANLHHRPEPSSGLEVLETENFRMQCFNTLTGTKFLLFTDTTQVNVDLTLRRIYDLYSDYVMKNPFYSLEMPIRCDIFDRKLLSYIREINNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLP2</accession>
    <name>A0A367LLP2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_6526</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLP2"/>
    <dbReference type="STRING" id="1330021.A0A367LLP2"/>
    <dbReference type="OrthoDB" id="190201at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016776813" description="AB hydrolase-1 domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="92"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI15331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="386" mass="42536" checksum="02BA4672C930BDF3" modified="2018-11-07" version="1">MFVPSMLVFLAAVTTAAARNCIEITVPVELRPRNVFYQVQTPKTEVDLISFVLDFGRRKPLLPQTLAKKSKVYNLATTYCWPDSGPGHSLQILTHGIGFDRSYWDFAHDNGRYSYVDRALARGYSTLSWDRLGIGASSHGDPINEIQLFLQMDALLALTSWVRSGGLPDHHHRHSRMVHVGHSYGSALTTVLTNQHPSMTDCIILTGFSQVYKFLASFILAANLVSVKKIPSLAGLYDEGYVAPHTSIGVQTDFFAPHNFDPAVLQLATERRQPAALGELMTLSYVTSKSSYRGPVLLITGDRDIPFCGGNCSNTPFVGINSANMLENSRPNFASSSIFETVVVEKTGHGLNLEYTAPTTFKMMLDFADKHLPPSEAAGPSYRKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LM57</accession>
    <name>A0A367LM57_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_3545</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LM57"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI15508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="117" mass="12922" checksum="59729786E919FAEC" modified="2018-11-07" version="1">MRIVIEKSTIKGFLYKACYFAKADTIISRDSLARPTRFLDIVNASSGGIPIATIAFDNAKSRPNASNDSEGYLSLYKASSDALAALYIDSSVYREFNSNRRKREPSREANNGAKFAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LN18</accession>
    <name>A0A367LN18_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_3371</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LN18"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI15642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="66" mass="7744" checksum="75DED1E28425FE5E" modified="2018-11-07" version="1">MMKTKKKNKKSTYVYAMNMTKDNARQTNGPRSCLTAGKRNAHRHVLNLHVFRLRPPLNLLRDHFPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LN35</accession>
    <name>A0A367LN35_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinase</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_3168</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="4"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LN35"/>
    <dbReference type="STRING" id="1330021.A0A367LN35"/>
    <dbReference type="OrthoDB" id="2573163at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000824">
        <property type="term" value="F:inositol-1,4,5,6-tetrakisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008440">
        <property type="term" value="F:inositol-1,4,5-trisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF21">
        <property type="entry name" value="KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="205"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="310"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="434"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="735"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="794"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1121"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1220"/>
            <end position="1243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="9"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="65"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="229"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="269"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="326"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="367"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="443"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="750"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="826"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI15855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1243" mass="135912" checksum="EF25C27E89BB1314" modified="2018-11-07" version="1">MSGSPPEPENAAPPALLRPASRCAVADDDDVEGASSDSSPLSSVHGAASRVSASPNLSKSLDTPARPRDSHFGEDSKPVAARQPGPSLLTKALASARGIPAPDAHLHEVLLPTPPQPDHLTSNPRASPDKKPPIARPSRDGLASDGQAHAPLDRGVSQPAAMIASVPVSPGPWSHNRTAMAYMGDVLAVHRNSSSDVAENKHLTSLGLESSSPGLSHRSSSSGRGASPQNAITPTKFSSMEMSEPLHPSSSPPARDTLRTPRPSSLRHSNIEHAVTRTPEKTEKAWSIGSVGGDEADGLVEQSVTEAMAGVEPNARSRKASYSLRFFKEGLPQDEKGRRKDTRQGHRDRLPSASEEGPQQTFDYAPSTPPSSLPLPTPVAEVPSSCGTTGQEEPAYFALDRAVSPALSAQPRRGDTMQPAAEAIDGLLETTNDASAGEHLDGLDADGDADAEADAEDSGEEKISSAVFLPHQEMPEARLRAGPGLNTACIAQPRSLSHSKAHPWLVKADEPEPEPEIDDKDEPALSSPRVRPRETLVVRRGDECALEDDGEVKSYVPCRVSSEDKVHVRKPLEAIELIPYKHQVGGHTTLWRFSRRAVCKQLNNRENEFYETIERYHRDLLPFLPRYIGVLNVTFQKLSRRKSAAKKDDSATVDRRKVLGEATKENLSEATKESVGDATRDTLANGNGNGVARPMVSVRVVSQSMAGSSLQIPTVTFDDNKHILPRNLLQPTASPEFFRRRSVSTDAVDPSPPRPSPLPRPALDERPNSWGATTINKRLRNEVFNDAFLKAPVEVQKHRRPHQRAIPRPIRPSHSDPNLGPPDMPTQDSSQAPSSPLGSHHEPSARPRPVSDLLEPVSRVTIEDITGSSAPEPQTLKSELVAGKKKRRFSAGGLRRKPEDVREPRGSLKYFEEADDVDDFKAAARNARVIEEATPAVDELLDPTIEFRKIPRPINPKEAKKEAQTRPDRVEYFLLLEDLTAGMKRPCMMDLKMGTRQYGVDATPKKQRSQQDKCLRTTSAELGVRICGLQVWNARTQSYDFQDKYFGRQVKAGPEFQAALQKFLYNGVELESVLRHIPLVLQKLARLEHIIRGLRGYRFYAASLLMFYDGDATEDGGYETMYDSTTDGATDTEETSRRKRKNRRDIDFKVADFANSLTPLDKMHDRPCPPQHPEQADGGFLKGLASLRNYFLRIQSDVRAELGMGSPGLREPRARLAVDGDGAINDDAGGRAEIQDEEGFISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LN61</accession>
    <name>A0A367LN61_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2777</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LN61"/>
    <dbReference type="OrthoDB" id="5397183at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="272" mass="30491" checksum="A68F63E2F31D72C8" modified="2018-11-07" version="1">MAGPNKRRRDRHPDVIHTAPDAKRCALSRDDNMESPDTCSLELPDHDIADLYDQLGLDIQAAEQPLMTIDDILDEALFVEDDEPRHSNELDSALPPSSLVRALDRASRSADEFDPDLLYSTPSSSTGARATQPQHVIPPLTQDSTNWEDVRLSLDDDDDDDDDACKIQPTHRPTNESVALPTPTASALPSPSSSSATWEATAQRANPSTFFFHVQDMLSAKAAMYKNQPHVALDWYARVLYSSRENFFRKQYFQFRDLFKETPPYLTGALVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNA3</accession>
    <name>A0A367LNA3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Isocitrate dehydrogenase [NADP]</fullName>
            <ecNumber evidence="11">1.1.1.42</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L249_1938</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:19629"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.42"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11 14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="11 14">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="11 14">Binds 1 Mg(2+) or Mn(2+) ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.42" evidence="11"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNA3"/>
    <dbReference type="STRING" id="1330021.A0A367LNA3"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004450">
        <property type="term" value="F:isocitrate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006097">
        <property type="term" value="P:glyoxylate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006739">
        <property type="term" value="P:NADP+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000002">
        <property type="entry name" value="Isocitrate dehydrogenase [NADP]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004790">
        <property type="entry name" value="Isocitrate_DH_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00127">
        <property type="entry name" value="nadp_idh_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006156">
        <property type="entry name" value="PRK08299.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822:SF21">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NADP], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11822">
        <property type="entry name" value="NADP-SPECIFIC ISOCITRATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000108">
        <property type="entry name" value="IDH_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0329">Glyoxylate bypass</keyword>
    <keyword evidence="6 11 14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 11 14" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 11 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11 15" id="KW-0521">NADP</keyword>
    <keyword evidence="8 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="16">
        <location>
            <begin position="42"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="108"/>
            <end position="110"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="127"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>D-threo-isocitrate</name>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="342"/>
            <end position="347"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="12">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="site" description="Critical for catalysis" evidence="12">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR000108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000108-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCI15867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="443" mass="49688" checksum="9AD71BD5A39722FA" modified="2018-11-07" version="1">MTPSSRLFLLTLSRPLRGRSMATSTITTTSSSTTKKIKVRNPIVELDGDEMTRVIWKDIKHKFIFPYLDIDLKYYDLGLEYRDKTDDQVTLDAAEAIKKYSVGVKCATITPDEARVKEFHLKQMWLSPNGTIRNALGGTVFREPIVIPRVPRLIPGWQKPIIIGRHAFGDQYRAKDMVVPGPGKLSMVFTPDGGSPQEMDVFRFEAGGGVGQTQYNTDESITGFAHASFKLALDKALPLYMSTKNTILKKYDGRFKDIFQHLYDTQYKKDFEAKGIWYEHRLIDDMVAQMIKSNGGYVMALKNYDGDVQSDIVAQGFGSLGLMTSVLITPDGKTFESEAAHGTVTRHYREHQKGKETSTNPIASIFAWTRGLVQRGKLDGTPELVSFAESLEQACIDTVDIDGVMTKDLALACGNKERSAYVTTTEYMNAVERRMKTLLRGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNG4</accession>
    <name>A0A367LNG4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_3021</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Prohibitin probably acts as a holdase/unfoldase for the stabilization of newly synthesized mitochondrial proteins. Involved in mitophagy. Required for the switch to necrotrophic growth.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">The mitochondrial prohibitin complex consists of two subunits (PHB1 and PHB2). The subunits assemble into a membrane-associated ring-shaped supercomplex of approximately 1 mDa. Interacts with ATG24/SNX4; the interaction is direct and plays a role in mitophagy.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prohibitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNG4"/>
    <dbReference type="STRING" id="1330021.A0A367LNG4"/>
    <dbReference type="OrthoDB" id="275637at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035632">
        <property type="term" value="C:mitochondrial prohibitin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF0">
        <property type="entry name" value="PROHIBITIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="5">
        <location>
            <begin position="26"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00053189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00066275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI15975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="274" mass="29978" checksum="B4C4C73EECCCCA3F" modified="2018-11-07" version="1">MAATSLSWLYRSIVPATGIALLTQASLYDVRGGTRAVIFDRMSGVKENVINEGTHFLIPWLQRSIIFDVRTKPRNIATTTGSKDLQMVSLTLRVLHRPIVTALPKIYQRVLPSIGNEVLKSIVAQFDAAELITQREAVSQRIRNDLTRRAAEFNIALEDVSITHMTFGREFTKAVEQKQIAQQDAERARFIVERAEQERQANVIRAEGEAESAETIGKAIAKAGNGLIQIRKIEASREIAQTLSSNPNVAYLPSGSKQGGGGGGSQLLLSVGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNJ1</accession>
    <name>A0A367LNJ1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">High-temperature-induced dauer-formation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2058</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNJ1"/>
    <dbReference type="STRING" id="1330021.A0A367LNJ1"/>
    <dbReference type="OrthoDB" id="432953at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000138">
        <property type="term" value="C:Golgi trans cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026705">
        <property type="entry name" value="Hid-1/Ecm30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21575:SF12">
        <property type="entry name" value="PROTEIN HID1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12722">
        <property type="entry name" value="Hid1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="574"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="634"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="690"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="702"/>
            <end position="714"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="872" mass="97014" checksum="4F19D3C2FBA82365" modified="2018-11-07" version="1">MGASDSKIVFKQGIFRLSKERHIPADDTYWTSFWELPESAEDVFSLFSPADIRRTRDQALENIETLVLALTSRLFILRHHPSFPDPDLAPERDALNCVRILTRILPYLYEQDSLKAWEERFFWGARRKKSRRATIANEVLFDEAQDGRQDSLVENDEFLDVKPLAEELIDTLIDLLFFSDLTIPRQPHGQSKITYAIWQSGVGCNMAVATTKEFENNRCEILRLLLALAGQSMYITPGHLPQRGVRTLTYLCTCQDKQVVLSVLCSLLNTTLKYNPASWRVPYNTLVFRDPKQILVTYSLQLMLVFLVYPIPEHASAQKNYYRHFLGRLHRPQDFQFIVDGISRILSQPLQDKTSYLPGSQASGNLTPEMLILFWELTQCNKRFRSFIIDTDRAHDFVVLILFHALEYKSDPAKQGVVRMCAFLLQTLSVEPNFGHNLNKCFEGQESLPACIRINGFNGSYTDFLIHSIYNLITTSQGNFSAVYPALLAVINNIAPHIEGLGASGSSQLMHLFSSMSSPSFLLANETNHTLLDSLLESINSIIENKYRENPELILAIVKSRKRFEALRSLTLESGQEELERRNRRKKDAAGQGDNADTGSVRSSLDSARSPPPAPSRIPTLGQVPEDGAFAIGDNEEDDSDDDPQPTPAPSTTSENQSQASSAVNIDEAVPPQLRGMSEKARGKMPAATRSFSRQNSTTSLGSQSASGRAQSGGFEPTAQWIDSWLPELPLHSILSVIQQVTSAGAERDAPSMDAVRRVQEMGLVGVDPSPPHVHSFEWSQPALAWYESLLWGMIFTSEMQIAKGTMGMWNGTSVKLFRVQETAPEGPTLTSPRGAVDAVGSNIVSRIGQINLRGGPAAQVGGSSSSSRSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNN2</accession>
    <name>A0A367LNN2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like 1-activating enzyme E1A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_2990</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNN2"/>
    <dbReference type="STRING" id="1330021.A0A367LNN2"/>
    <dbReference type="OrthoDB" id="1708823at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000011">
        <property type="entry name" value="UBQ/SUMO-activ_enz_E1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF162">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01849">
        <property type="entry name" value="UBIQUITINACT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016858927" description="Ubiquitin-like 1-activating enzyme E1A" evidence="7">
        <location>
            <begin position="25"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="8">
        <location>
            <begin position="49"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI15991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="351" mass="37861" checksum="81B7462EF3A9F7F3" modified="2018-11-07" version="1" fragment="single">MNDRPMMQMPVGVADLLMPVAAAAATTNGSQMQATGDESIVSADEVALYDRQIRLWGMAAQAKIQNASVLLITIRALANEVAKNLVLAGVGSLTLLDGNTVTESDLGAQFLLSDEGDVIGQNRAQAASVALGKLNRRVQIHVDTDNVVAKGPSYFAGFDVVIATDLSPDSFNIINTATRLNGKAFYAAGTHGMYGFIFSDLIEHDYVIEREAGNTDGAKTMESVTKRELYSTWFLASDLATLPDDYVKSRRRLKSVTPALSCLRALWEFTEVKGGALPGNRDDLRLFTQMATQKHKALSLPSETLRPDFLRSFLQNLGSEMAPVAAIVGGQLAQDVINVLGQTQQPIQNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNR1</accession>
    <name>A0A367LNR1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNR1"/>
    <dbReference type="STRING" id="1330021.A0A367LNR1"/>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF414">
        <property type="entry name" value="CONTAINING AMINE OXIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="1">
        <location>
            <begin position="77"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="554" mass="61847" checksum="83B76F346C8CA852" modified="2018-11-07" version="1">MENFSVCHSSPRNTSSKIYQDLRSVRLASLPGLGRDHLLRKVAAMDFFAQPIKLLPQCKNNNDPMAKPHVAVVGAGLAGLRCAHVLQRHGFRVTVVEARNRIGGRLWQVKLANGHLVDVGPNWIHGTLDNPMHDLARQTKTVVGRWEPVSNVFDQTGSLFPPEDGEKYADVMWDIIQDAFKLSNKSCLDIHSAKSLYDYFHERVAERFPDTEPDSEHNKRVVLQLAETWGTFVGSPVSRQSLKFFWLEEIENLFCAGTYKKILDVVARPVLAESEVLFDTKVQRISCRGQQGEKTRLHVVDGDGQESVLAFDDVVVTCPLGWLKRNVEAFEPPLPPRLSQAIGAIGYGCLEKVYVSFPKAFWLSEDGDENQIRGFIQWLSPDYAPESNPDRWAQEAVELASLEPGSSHATLLFYLYGDQSRHVAEKLAALQTEAERDRFLADYFKPYYSRLPRYVESSADCRPSACLATAWVTDELAGFGSYSNFQVGLEEGDEDITTMRAGLPERGLWFAGEHTAPFVAIGTATGAYWSGESVGRRVAEAYGLASSSLQRKGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNW0</accession>
    <name>A0A367LNW0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dolichol-phosphate mannosyltransferase subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_2527</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER.</text>
    </comment>
    <comment type="pathway">
        <text evidence="7">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DPM3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNW0"/>
    <dbReference type="STRING" id="1330021.A0A367LNW0"/>
    <dbReference type="OrthoDB" id="2014333at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033185">
        <property type="term" value="C:dolichol-phosphate-mannose synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013174">
        <property type="entry name" value="DPM3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16433">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16433:SF0">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08285">
        <property type="entry name" value="DPM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI15932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="92" mass="10226" checksum="0C6E4E9C37C67F04" modified="2018-11-07" version="1">MTRAQQTISLGLLVSSLYLALYLELIPLPPLVQHKIVPVLPFWALVSFGALLLFRLGLGLVTFNDVPEAHKELMLEIDMAKADLRTRGVDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LP14</accession>
    <name>A0A367LP14_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Cytochrome c oxidase assembly protein COX15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_2756</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Fe(II)-heme o + 2 A + H2O = Fe(II)-heme a + 2 AH2</text>
            <dbReference type="Rhea" id="RHEA:63388"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:60530"/>
            <dbReference type="ChEBI" id="CHEBI:61715"/>
            <dbReference type="EC" id="1.17.99.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:63389"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Porphyrin-containing compound metabolism; heme A biosynthesis; heme A from heme O: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LP14"/>
    <dbReference type="STRING" id="1330021.A0A367LP14"/>
    <dbReference type="OrthoDB" id="1726137at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120547">
        <property type="term" value="F:heme A synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016653">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006784">
        <property type="term" value="P:heme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01665">
        <property type="entry name" value="HemeA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003780">
        <property type="entry name" value="COX15/CtaA_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023754">
        <property type="entry name" value="HemeA_Synthase_type2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23289:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02628">
        <property type="entry name" value="COX15-CtaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016711379" description="Cytochrome c oxidase assembly protein COX15" evidence="13">
        <location>
            <begin position="18"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="329"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="383"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="494"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="519"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI16185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="564" mass="62639" checksum="2CB40C53CCCF904F" modified="2018-11-07" version="1">MRVQSLVWSLLASSVTGSLSKMAKPVQPNRWKPLGPPPDWNGLAATVQLTCYSQKLFFYSTYRYNITWWRDGDVEIRCNNCRKPQQVTQVNFLVGQSCVLDDASITPSVTFDSPTCHLLSVTCQPGFFGQYGSWSWNTGIIVRSDGPENWAGLVQRPGIAIQFRQQSGKETTLNHYPVKGCTVMGLVFGIVVFGGLTRLTESGLSITEWRPVTGSLPPLSPSDWSSEFEKYRATPESKLLNPHMTLDDFQRIYLMEWTHRLWGRVIGLSFALPAIYLVARRRVPARMSFHLVGISALIGFQGFVGWWMVRSGLRDDLFAPGSHPRVSQYRLTVHLATAFVCYSWMLLCGLSVLRSHRLPPLSAAAAMAATASHPALVPFRRCALALACLVFLTAMSGGLVAGLDAGLIYNEFPRMGLGLTPPRTELWDGFYARREDQSDLWWRNMLENPSTVQMNHRILALTTLCSVLALFAYSRTRPVAAVLPPGARRAANGLVHLVALQVTLGISTLIYMVPIPLAAAHQAGSLALFTGVLVLAHRLHVPRCAVRIIDRQLKRPPSRPVKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQ74</accession>
    <name>A0A367LQ74_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_2648</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQ74"/>
    <dbReference type="OrthoDB" id="5401654at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39610:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39610">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="154"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="302"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="168"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="230"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI16537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="411" mass="43929" checksum="02C6AA30AE90E4C2" modified="2018-11-07" version="1">MPDLNTVPPSPRALAAPPSRRRRSSQNVISASASLNILPSNQNVVVSSHGRTSSRGGGGYGGEPQQQQLSSNMPSPEGSAVGPGPGPLRHPRPLTASELHMQLEKEQEAVVNRLTRELSLLRAAHNASVASNTSSTSATPSHDAVADSSLLSGAGFSIPTPRRHHRNSSATSQQHFPVQLASSHEARQQRPSVPLSRQDSAASRRSQTNSPAPHYHASAAGFVDQPPGYFHHHHHHHHHHHQLQRFPPPYSHSSSSVQMGSLAATTPGSATFPDHHHHHHHHSAQQQLSPGLMPATSRYEETAFYRNELETAKKENDGLKRRIRELERMVQCRRAAERARSPSDAASTAVNASMALTRDLVGGGGGQESRARGMASQSVASLSSLGVGVPEDEVRVGESAASAGLGNNNPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQE6</accession>
    <name>A0A367LQE6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">ABC transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_1739</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQE6"/>
    <dbReference type="STRING" id="1330021.A0A367LQE6"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000967">
        <property type="entry name" value="ABC multidrug transporter mdr4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000057">
        <property type="entry name" value="ABC multidrug transporter SitT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000251">
        <property type="entry name" value="ABC transporter B family member 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF11">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="694"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="739"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="817"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="841"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="922"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="955"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="54"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="379"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="699"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1030"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1002"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1002"/>
            <end position="1016"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI16684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1277" mass="138547" checksum="D726589DA7D43A21" modified="2018-11-07" version="1">MAASDEKVMAQADDGDSHSDSDQTGPKSGDGGASFKYLMRVFHYNDSRGWLMNAIAFLCVVASSAALPVMDIIFGRFVDVFNDFAAGRLSPAAYRSEVSRFSLYFVYIFIAKLILTYIWTVLVNVTAIRATKALRVDLLRQLLRQEIPYFDAPSSSVSNQITTNGNLVSNGISEKLGLTVQAVSSFVIAFVVAFAVQWKLTLIVLAIVPLNVIVTGGCVARDVSLEYRMFDIYAESGVLAQEAFASIRTAHAFWVFPRLARRFDAILDRARSVGDGKSIVYAILFPIEFFCVISGYALAFWQGMRMYRAGEIADPGTVVTVIFAVLVAAQALTQIAPQTIAISKATAAAKDLFRVIDRQSAVDSLSEEGACLPDLRGEIELRNVRFVYPSRPEAVVLDGFNLKIPAGRTTALVGASGSGKSTIFGILERWYPFLAGDVTLDGQDITSLNLRWLRTHVRLVQQEPTLLSGTVYQNVVDGLAATDLAGVPDDEKRRLVIEACQAAYAHDFIEDLPNGYDTDVGERGCSLSGGQKQRIVIARTIISNPRVMLLDEATSALDPKAEKVVQAALNNVGKGRTMVVIAHRLSTIRDADNIVVVSKGEVVESGTHQQLIDRGGAYARLVEAQNLGGGGVDDKEKERKNEMDGHDADVADFDLASTHASTMAESNLPPGRSGDGEFGLLRGLYLILSEQRPLWGPLALTAVCLIIAGGTSPALAILFAQTLDAFERVDQSRANFIALMFFVVALANLVAYAIAGWLANVLAQTVMRFYRSEIFSNTLRQRMAFFDRPDNSTGALVSRLASEPTSLQELLSVNMELLLINAINLVSSAAVAIAYGWKLGLTLALGVLPVLVLAGYIRIRLEYQFEKDTAALFARGSGIAAEAAMGIRTVSSLALERVVVGRFEEALRNVASRALTGLGWRMFFYSLSQSVSFLASALGFWYGGQLVSTGEYSNTQFFTVFMAVIFSGEAAAMMFQYTTSITKAQAAINYIVSLRRSVELLDDDDDNDDEDDDEAEYSSPQQEKKLGMAAACEEVNFTFPQRPRQRVLRDINLSVAPGSMLALVGASGCGKSTIIALLERFYDPDSGMVRLDGHDARSQGRQRLRRDVALVQQEPVLYQGSVRDNVSMGSPSSSLDTKAIEAACRAANAWDFIASLPEGLETPCGGQGLALSGGQRQRIAIARALVRRPRLLLLDEATSALDSESERLVQQALDGAAAGGQATTVAVAHRLSTIRGADMIAVLARGCIVERGTHEELVARRGVYYDMVLGQSLDREM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQH6</accession>
    <name>A0A367LQH6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_1925</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQH6"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI16714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="100" mass="11294" checksum="658DED795A04D158" modified="2018-11-07" version="1">MDVEEDEADDRFEERWLDGLVLALVAVIRGSMEYVRHRDDEEAPLWGNMHKGEGERESEHVSCRGTMRRPGCLSSVRVMMVLGGAGDRRAGEESELTSWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQK8</accession>
    <name>A0A367LQK8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQK8"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="161" mass="16431" checksum="53FD791C194FD775" modified="2018-11-07" version="1">MPLALLEQGGSGSSSRSNSSRSSSRSNAWPRGEGGRASLPPTIGGEEGIKRAKLAQKAAAAAALIAATASTNDFARNKAEVDNYANRAANAGRVEAVAAAAVAAANVAAAREAKKAVFTAATRAKQREEAYRAAKRAAAPARARAALAALDKELAQQECRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQZ3</accession>
    <name>A0A367LQZ3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Integrase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_1770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQZ3"/>
    <dbReference type="STRING" id="1330021.A0A367LQZ3"/>
    <dbReference type="OrthoDB" id="4924025at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015074">
        <property type="term" value="P:DNA integration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001584">
        <property type="entry name" value="Integrase_cat-core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013103">
        <property type="entry name" value="RVT_2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07727">
        <property type="entry name" value="RVT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50994">
        <property type="entry name" value="INTEGRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Integrase catalytic" evidence="2">
        <location>
            <begin position="295"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI16863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="486" mass="55131" checksum="BEE2A95969EB4F95" modified="2018-11-07" version="1">MPALPANHKKAVDFSLIYRRLGHARKERILEACRKSGIAVKAPGDFHCRSCHLGKAEAIVSRDPSVQATSFLQYIFWDFLQHTPTSSEGYRYTLHVVYEDPCVMTNRKLIIFFYVDDLVAHFRKEFAEEHARFKEAIGKAFEIKDLGDLRRFLNMEIVRDRANRRLWLSQRSYVQKVVAKFKGLTSYHQPLQPMTLEKIPPFEGSASETEIKTFQAIVGSLMYAAIITRADIAFAVGKLSRPGKAEDLLHKDPDFGPLTPDSLEGIGNAVFSLSQNLTTAPHRDRLPDPPLTYREPRRPWAVVSFDLFNFGGGYNGSLYLALFTDIFTGERIGHDLPLKSDLPSVWIKFTSFIKRRFDLTVSVILTDHKKALFTEAFQDNLAFEGIEIRFSSPAHKPIFLPDEDKFVRARNVRFHDPADSSYSFDKTITHIGQLQVISPVTDWIHTGESRSIASQTLQCQAFADKADRKSSQSQAYAIWPLGGIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LS45</accession>
    <name>A0A367LS45_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SAM-dependent MTase RsmB/NOP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_2168</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LS45"/>
    <dbReference type="STRING" id="1330021.A0A367LS45"/>
    <dbReference type="OrthoDB" id="435282at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1170:FF:000006">
        <property type="entry name" value="NOL1/NOP2/Sun domain family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1170">
        <property type="entry name" value="Sun protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049561">
        <property type="entry name" value="NSUN5_7_fdxn-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048889">
        <property type="entry name" value="NSUN5_RCM1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF4">
        <property type="entry name" value="28S RRNA (CYTOSINE-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21148">
        <property type="entry name" value="NSUN5_fdxn-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21153">
        <property type="entry name" value="NSUN5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="7">
        <location>
            <begin position="134"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="341"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="526"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="537"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="549"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="581"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="418"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="240"/>
            <end position="246"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI17180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="611" mass="65983" checksum="348847ED396E2D1A" modified="2018-11-07" version="1">MSLYHEAAEILSKAQSEGGSLKSLVFGGKKAVKSQPNQLYALVVETTKWSSVLKEVIEAAELLKQERKLTPVLSLLLVHDLLLTKRGISLAQNHGLRASVERHKGRLKSEITRARLRRRASSLQDLAAQVHEAAAGEETAASPRWVRINSLKSSVEEQLETTFASYARAACVADVVSKTDRRHIYIDTHVPNLVAITPGTDLTKTGAYLSGKVILQDKASCFPAYLLDPRFEDGDVIDACAAPGNKTSHLAAIIEAHRPTLPLERQTIFAFEKDARRAQTLDERMRAAGCKRITRIGFAQDFALVDPHGDRYSKVGALLLDPSCSGSGIIGRDWMPQLFLPGTPKKAVTSKKRKRRDGDGGTTGPDKKKMKVVRDDETAEDRDLLLSGRLKALSSFQLALLLHALRFPAAKKVTYSTCSVYAEENERVVMEALKSDVARTRGWRILARGQQVRGMREWPVRGLKEECEGEAEVADGCIRCYKDDGRGTMGFFVAAFCRDGDGDGEEAGSDGAEPYVRDEHGRIVRDVLGMPTLKTTGEGGGGGGGGGAESKRLDGGEDDEGKDKEKVAGGAGSQAAGPDGDASDSDLDEDGDDDGGGGDDDDDDEWGGFGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LS50</accession>
    <name>A0A367LS50_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L249_2244</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the cleavage factor I (CF I) involved in pre-mRNA 3'-end processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LS50"/>
    <dbReference type="STRING" id="1330021.A0A367LS50"/>
    <dbReference type="OrthoDB" id="10249535at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16292">
        <property type="entry name" value="CPSF3-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000001">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10890:FF:000004">
        <property type="entry name" value="Cleavage and polyadenylation specifity factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021718">
        <property type="entry name" value="CPSF73-100_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050698">
        <property type="entry name" value="MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203:SF11">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11718">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01098">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="12">
        <location>
            <begin position="37"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="13">
        <location>
            <begin position="263"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term" evidence="14">
        <location>
            <begin position="526"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="599"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="712"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="762"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="605"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCI17217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="880" mass="97343" checksum="0FD6C9D8DA7E9C96" modified="2018-11-07" version="1">MASKRKASAMQATVAEEPVDPTDELMFLCLGGGNEVGRSCHIVQYKGKTVMLDAGQHPAYDGLAALPFYDDFDLSTVDVLLISHFHVDHAASLPYVLSKTNFRGRVFMTHPTKAIYKWLIQDSVRVGSASSKQASQPVYTEQDHLNTFPQIEAIDYHTTHTISSIRITPYPAGHVLGAAMFLIEIAGLNIFFTGDYSREQDRHLVSAEVPKGVKIDVLITESTYGIASHVPRLEREQALMKTITSILNRGGRALLPVFALGRAQELLLILDEYWSKHAEYQKYPIYYASNLARKCMIVYQTYVGAMNDNIKRLFRERMAEAEATGDGAGKGGPWDFKYIRSLKNLDRFDDVGGCVMLASPGMLQSGVSRELFERWAPSDKNGIIITGYSVEGTMARQIMQEPDQIQAIMSRSTAAARRAPGGESDKVMIPRRCSVAEYSFAAHVDGVENREFIEEVAAPVVILVHGEQHNMMRLKSKLLSLNATKTSKVKVYSPRNCEELRIPFKADKTAKVVGKLASIPPPLVREPTTAPLVTGVLVQNDFKLSLMAPDDLREYAGLNTTTIMCKQRLRLSAAGIDLIKWALEGTFGSVEELPEMKTRAAANKDGTHDDVDMSDGPAKKEEEQEQDKDDNNGSKDKKPSKKQVKAGIRDEEDVVDEVSRPVAAYLVMGCIAVRYRSDGEVELEWEGNMLNDSIADSLMTVLFSVESSPAAVKRSSANGKQHAHDGQDEDAAGKNPHGHCSPSDRLARLFWFLEAQFGADNVSPVSSLPGREERTAEEDQEEGKGKMKTDEDDEQQEREKQAAEAEEAEADKADGEKDKAELARLHALGIPVPGIRISVDRLLATVWLEKLEVECNNKVFADRVRAVVERAVEITAPLWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LS58</accession>
    <name>A0A367LS58_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_2280</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LS58"/>
    <dbReference type="STRING" id="1330021.A0A367LS58"/>
    <dbReference type="OrthoDB" id="2365484at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06090">
        <property type="entry name" value="KOW_RPL27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.770:FF:000001">
        <property type="entry name" value="60S ribosomal protein L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001141">
        <property type="entry name" value="Ribosomal_eL27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018262">
        <property type="entry name" value="Ribosomal_eL27_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041991">
        <property type="entry name" value="Ribosomal_eL27_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038655">
        <property type="entry name" value="Ribosomal_eL27_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10497">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01777">
        <property type="entry name" value="Ribosomal_L27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01107">
        <property type="entry name" value="RIBOSOMAL_L27E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI17284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="168" mass="19297" checksum="386209F7B08EC1B3" modified="2018-11-07" version="1">MRVTAAEMPMKTAKTGSATREIIQQRSAKQQDTMKFLKVGRVAIITRGRYAGKKVVILQPVDNGNKPHPFGHAVVAGIERYPSKITRRMSKARQEKRSKIKPFIKIINYNHLMPTRYTLELEGLKGTISGDTFKEVSQREDAKKTVKKVLEERYTSGKNRWFFSPLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LS78</accession>
    <name>A0A367LS78_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ERT1/acuK family PAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_3236</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LS78"/>
    <dbReference type="OrthoDB" id="65716at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090173">
        <property type="term" value="P:regulation of synaptonemal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056751">
        <property type="entry name" value="PAS_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039057">
        <property type="entry name" value="Spo22/ZIP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013940">
        <property type="entry name" value="Spo22/ZIP4/TEX11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40375">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40375:SF2">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24990">
        <property type="entry name" value="PAS_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08631">
        <property type="entry name" value="SPO22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0469">Meiosis</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="ERT1/acuK family PAS" evidence="9">
        <location>
            <begin position="418"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="103"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI17306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1446" mass="158692" checksum="CC243C09B592336E" modified="2018-11-07" version="1">MDGKAKATRSEDPPPKDAADEDTADGEEEEGGGGGGGGGGGGGGGAGGEADRKAAEHCGSSHRPGKSPKRRRKVNHACVYCRRSERPCSRCIKRNIGHLCHDEPRDAEAKKPRGSKPSIEEAEAPAPAPEVGRNNSMSGSTMGPPPPAAFNGRPQQHQHQQQASTDFGSVSVVGQPHALSLVQPAAGTGLQGDGLANSTNGNANSLADAWLTAQTFSDMSSYNPNYMIAPHVSHEFNLLDDFLQGGFLDMDPLAPDDNANSTAFGRTGGPSGTLSGFGGGGRPSLPVGLGVGLTETSTPMRVSASATDKTREYYLQAADPSGNDNAEERMARVLRAKYDAGLLKPFNYINGYARLGKYLDGHIAPSSKQKILRTINQFRPKFREKAQGLTDMQLVYVEMWFERQLMDYDRVFASMAVPACCWRRTGEIFRGNKEMAELIAVPVDELRDGKIALHEILTEESMVRYWEEFGTIAFDPAHETLLTACSIKNPSDSSDHPIVKCCFSFSIRRDEHKLTVRSIIDFAAELETKLPTLRDVGAVDVLAADLGQRLQAIQGLQMRSGGGGFNGVAGRDMERRGRSLWNVCIRTKRDAVLKGPLAGLLLSARVLAFHMLEMGRGSREEEQEEDVVYLLGLALTLARICVVDFELGQATLALRKAAGYVERLGRRPAVDGLGRLARRLEVEYLTMRMTLAWREDRLDVAEHMYGKTDALRRNLDAPAAETMADALRHIGADLSSKGNHTLALQWLRRAHELIDALSPEHLSTLGLELRLAICHGRVRSLLAMCSPESLQEAEDLVAYVESELGDKPVVLHWRLEILKKSPKDVMGAEALASILRRMVRCFDRSDDTLQFLLHQFTELGRDSERLASGLLDELMRQHVLRSANPVWIGKVMVKRTEMATATSHTDELLASLRGLMDEAHDALSGPLKPEAAGAAHSLVWTKAEALFVAQEYATADAWCELGLHDLFASAGEANAGKFGRKRILCALKVNDAERAKEAYQKMPEGPQLDDLSCYLMFKVSLLCWDHELGCRSITQLSKASGTARGRDMLYACVREAQQFGDRLCAVTALRAVADSWAVGPVSPEGLPAVLRCTIRLMHMTGEEEEESDASGEGRRQDNDFAAETCDVFEKGASAAEHATQGPRDEQGKKVFTIPELHWFRKNAYNLGATKCHAWPLPLVIRLFGACLTIIDCYPDDMPVTDETELKTMAMRCHFVISAASVSLARAEDRVDEQLQRYVEARRHVAAFDQLMQAGVCFNDEAVARDTASKMATLFVFDFEGAACLKGWDDLGSIVRKAKTCKDEVVFKAMGDCLLRSRAPGRVMYATMRLIINEIFELEEFDCKQLAKYVRCLVQAVLPLDDSLALQLADQALQIAREGQQVGRPLPAEELEWLVATSFNHAVDLYARADEAGCHRWALKAMGLAEFARDGGALAGMLRDRFSRLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LS99</accession>
    <name>A0A367LS99_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_2283</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LS99"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI17279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="427" mass="46659" checksum="6763B5E823148E90" modified="2018-11-07" version="1" fragment="single">ADKKRRPVDFIVRDKVFLRRKGFSIIAPTTRLNAYLQYARVGSRLRSPFSYYREELASRQGYNPNDTWYPARNFKNAPVALRDYYNRYLDAAAADKLYNDDDDDNRAATTRAITRAVTTATATAVRAIRAPAIAAAAAADPEGLFNHRLLRGGEDEGPALADLETFFLPTAGELTADSTLFFFDLCSRYGYGKRPRCYSSSTASSFPLERSLRPDFFGCFFRPLVFCPFLPSLFFLRPALRPIAIIGTGSGSGLGLGLGLAAEYGYGPGIAVIIAVTIAVIIAVIIGITAADDRTYGRTVPTPPIVVTFVFVFVFFFFSSGSFPPPFPAESFVVPFVFFFVFSFLRPYPPPITFLRKGNLAVPRLIRGTSPRSKSTRPEGLGGSRDAGPAVAGPRPPYITAAVRGGYGYGYGYGYGYTGRTGPSFLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KYW5</accession>
    <name>A0A367KYW5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000042">
        <property type="protein sequence ID" value="RCI07357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KYW5"/>
    <dbReference type="OrthoDB" id="4930850at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI07357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="254" mass="27884" checksum="15310F0464065B74" modified="2018-11-07" version="1" fragment="single">VARHGGARYGGVARHGVWHGTARQAGRTERHACMPLLQGTAATGSRVRQAAAAGVAPHFFQQGSKRSSINFSSGLSSSSNHDHHQHSTIITTALLPHQLVFSEIQFLTMGSLFENSFYVPNCSQYEPLSPTEPLSPSTVKEEERGETQAAEPGPPISQLHNTNSQGRITKRRSTKPRSYDSSDLLLSALKCTVGKHLRMTGYLPLSIDPGSKIDGKIMSWKEVEEWDMIMGEKRTVKFSIDFKVLMGHGNFTRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZ39</accession>
    <name>A0A367KZ39_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Elongation factor 1-gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_4566</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000028">
        <property type="protein sequence ID" value="RCI07445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZ39"/>
    <dbReference type="STRING" id="1330021.A0A367KZ39"/>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03181">
        <property type="entry name" value="GST_C_EF1Bgamma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03044">
        <property type="entry name" value="GST_N_EF1Bgamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.10:FF:000006">
        <property type="entry name" value="Elongation factor 1 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000142">
        <property type="entry name" value="Elongation factor 1 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1010:FF:000001">
        <property type="entry name" value="Elongation factor 1-gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1010">
        <property type="entry name" value="Translation elongation factor EF1B, gamma chain, conserved domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050802">
        <property type="entry name" value="EF-GSTs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001662">
        <property type="entry name" value="EF1B_G_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036433">
        <property type="entry name" value="EF1B_G_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986:SF1">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00647">
        <property type="entry name" value="EF1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01183">
        <property type="entry name" value="EF1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89942">
        <property type="entry name" value="eEF1-gamma domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50040">
        <property type="entry name" value="EF1G_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="7">
        <location>
            <begin position="2"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="8">
        <location>
            <begin position="86"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="EF-1-gamma C-terminal" evidence="6">
        <location>
            <begin position="251"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="215"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI07445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="412" mass="46341" checksum="44A63CE836917D3E" modified="2018-11-07" version="1">MAFGTLFTTADNARSVAIKAIAKANNLDLKIVEVEFGSPSMEHRKANGLGKIPAFVGEDGYTLSECIAVAIYITSQNEKTTLLGKTKQDYASILKWMSFFNSEIVPPLGNWFLPLVGRVPYNKKTVEDGSKATAKAIDVVENYLARHTYLVGERITLADLFCASLLNRGFQYFFDKQWRQKNHNVARWYDTIVNQPIYTAVAKKLEYLEKPALTNTAPKKPEQPKAAPKAAAAPQAAAADEGEDAPAAPKAKHPCEALPKASFALDEWKRHFSNNETPGALKWFWSNVPLDEEYSIWRCDYKYNDELTLTFMSNNLIGGLFARLEGSRKYIFGSASVYGENNDSVIQGAFVIRGQEYMPVFDVAPDYESYEFTKLDPKNEKDREFLENQWSWEKPVVVKGKDYAHACGKVFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZI4</accession>
    <name>A0A367KZI4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000026">
        <property type="protein sequence ID" value="RCI07577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZI4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI07577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="78" mass="8151" checksum="D7CC3C785993EF06" modified="2018-11-07" version="1" fragment="single">SKGGSPLSNQDALNRDKHLAFLSSYSRGGEYSGLGRFRPGRIGTITVSPGALSGGAADGAMPNEKERKGTKEEDLLSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZR3</accession>
    <name>A0A367KZR3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5902</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000025">
        <property type="protein sequence ID" value="RCI07665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZR3"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI07665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="147" mass="16924" checksum="EDD8826D75783CCD" modified="2018-11-07" version="1" fragment="single">HSRAALSISYCRLDRYSIAKVAPFFEQGEEYAYNTEHFLNYLDSISIARALPLNWLPAIRNSLMPATKQRRHFLKSYNLYLARCLSILRMRFVDIFFATSLREILLALCVTPTPKAPSIISLLFKVSNFTDLFSKEKASALLPYYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZV6</accession>
    <name>A0A367KZV6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8339</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000027">
        <property type="protein sequence ID" value="RCI07502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZV6"/>
    <dbReference type="OrthoDB" id="4930850at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="768"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="499"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI07502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="789" mass="85864" checksum="B5D0DA2C56593C5A" modified="2018-11-07" version="1">MLPRIGVGREVGVARHGGARYGGVARHGQQVWHGTARQAGRTERHACMPLLQVWLLLVTDGTKSSINFSSGLSSSSNHDHHQHSTIITTALLPHQLVFSEIQFLTMGSLFENSFYVPNCSQYEPLSPTEPLSPSTVKEEERGETQAAEPGPPISQLHNTNSQGRITKRRSTKPRSYDSSDLLLSALKCTVGKHLRMTGYLPLSIDPGSKIDGKIMSWKEVEEWDMIMGEKRTVKFSIDFKHVGVGRHVGVGRDGGSRVRQAAAAGVAPHFFQQGSKRSPQKIRRGLRGVELSSINFSSGLSSSSNHDHHQHSTIITTALLPHQLVFSEIQFLTMGSLFENSFYVPNCSQYEPLSPTEPLSPSTVKEEERGETQAAEPGPPISQLHNTNSQGRITKRRSTKPRSYDSSDLLLSALKCTVGKHLRMTGYLPLSIDPGSKIDGKIMSWKEVEEWDMIMGEKRTVKFSIDFKSTRHYRILNQGCEAAPQQGSGAASTQRHTSIKTNPSSSSAISSNDPGSKENPPGLSNFRIAIIRADDGMVFMEAAGSFSSSTEKTQREGICDTAGRRYVWHGTARRGGGGRHVGVGREVGVGRHEGVRGDGGDRDGVPHKQAWHGTEADRAEPCMQQQVWHGTAGGPGGASRVHAAAAGVATSSHVWDGTEVWLLLGTARRCERGTAATGSRVRQAAAAGQVWHGTARQADRAERQACMQQVWHGTAQHGSHKVTLMQQVWLREAGPPKKYGGSYEVHQSTSPLLSSGFVVSLHTLNSNHRFDTKHGGFTSSPGGGDKGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZW6</accession>
    <name>A0A367KZW6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GTPase-activating protein GYP7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">GAP for YPT7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_5692</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000024">
        <property type="protein sequence ID" value="RCI07720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZW6"/>
    <dbReference type="STRING" id="1330021.A0A367KZW6"/>
    <dbReference type="OrthoDB" id="10264062at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000032">
        <property type="entry name" value="GTPase activating protein (Gyp7)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000005">
        <property type="entry name" value="TBC1 domain family member 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF502">
        <property type="entry name" value="SMALL G PROTEIN SIGNALING MODULATOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="5">
        <location>
            <begin position="430"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="250"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="727"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="254"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="730"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00072091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00082648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI07720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="770" mass="87772" checksum="A52C2B7C13B7ADDF" modified="2018-11-07" version="1">MADSPSASFYALSDDEEGGYDTVTLSDSARRGGVKLLFAKNKVYVHPTSSARDNVAGYIALLQQKSSSSPPPSSSSPSPSSSSSPASSDLLLAWVPESTLGEAAASRYAKVDLCDGDSPSSHPCLVPPPPTVTTHSGSVGGYAFAVPLSAIYSLIVRPPSAGWWHGSVIINARNGDGAFPALFFHDNECQSTMLQKKRLARDAFDPFSEGGQMFWGADEILRWLRRYVAVERAGAEPNVYLIEPSKEDVESFGQQQQQQQQRRRQQQQQQNSAAEAEEDPFVKFVKETGWNIMNQFSKVTTMTRRAAQDLADNSNMPPQVRRLLRNPEVQTLQDEFDSARIYLARWAMGIAEQSERDRRGRVWTARDVAELESTDVGEFELLDDMAGMSVEERRRPVTAEEWAGWFDKPTGRLLITVDEVKERIFHGGLDPDDGVRKEAWLFLLGVYDWHGSADERRAQESSLRDQYYRLKQAWWDRLDGHGGEGEEGEWWREQRGRIEKDVHRTDRNVPPFQGEDAPHPDPDSPFADVGTNAHLEQMKEMLLTYNEHNRTLGYVQGMSDLLSPLYAVTQDDALAFWAFEHFMQRMQRNFLRDQSGMRAQLLALDQLVNLMDPKLWEHLRKADSTNFFFLFRMVLVWYKREFLWSDVLSLWERLWTDHLSSQMHLFIALAILDKHRDVMIRHLHAFDEVLKYVNELSNRMDLESTLIRAESLFRKFQRLVDAIDKRNNFPRAPSSSSSPRPSSSSAENDENKTITPELRSLLSRKIVLVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0F1</accession>
    <name>A0A367L0F1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">Multifunctional fusion protein</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="10">Delta-1-pyrroline-5-carboxylate dehydrogenase</fullName>
                <shortName evidence="10">P5C dehydrogenase</shortName>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="9">L-glutamate gamma-semialdehyde dehydrogenase</fullName>
                <ecNumber evidence="9">1.2.1.88</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_5851</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6 9">
            <text>L-glutamate 5-semialdehyde + NAD(+) + H2O = L-glutamate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:30235"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="EC" id="1.2.1.88"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.88" evidence="9"/>
    <dbReference type="EMBL" id="LKCN02000023">
        <property type="protein sequence ID" value="RCI07894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0F1"/>
    <dbReference type="STRING" id="1330021.A0A367L0F1"/>
    <dbReference type="OrthoDB" id="5322683at2759"/>
    <dbReference type="UniPathway" id="UPA00261">
        <property type="reaction ID" value="UER00374"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:L-glutamate gamma-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07123">
        <property type="entry name" value="ALDH_F4-17_P5CDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000006">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000005">
        <property type="entry name" value="1-pyrroline-5-carboxylate dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005931">
        <property type="entry name" value="P5CDH/ALDH4A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050485">
        <property type="entry name" value="Proline_metab_enzyme"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01236">
        <property type="entry name" value="D1pyr5carbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862:SF1">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0520">NAD</keyword>
    <keyword evidence="3 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 9" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="11">
        <location>
            <begin position="82"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI07894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="573" mass="61854" checksum="76C579BE77ABDEC1" modified="2018-11-07" version="1">MQSAAFNRAGLRCASQASQRLGIGTLAAFKTPKVANEPNHHYAKGSSQRQSLMAAIDKFQKWLPVEVPVIIGGNKLQSPSSAIGQRNPSDHASTVASYHPATATDVTKAIEAALAAKPAWESLPFADRAAVFLKAADLIAGKYRYDVMAATMLGQGKNAWQAEIDAAAELVDFFRFNVHYAEQLLAQQPEHNAPGVWNRLEYRPLEGFVYAVTPFNFTAIAGNLPGAPALMGNVVVWKPSDHAILSNWLVYEILLEAGLPPDVIQFVPGDPSEVTSVALGHRDLAALHFTGSTAVFRKLYGAIGQGVAEGRYRSYPRIVGETGGKNFHLIHPSADMDNAAVHTIRGAFEFQGQKCSATSRLYAPRSAWPRLREKLVSETRSLTMGVPWEAQHFVGPVIHEAAFDRLSGAMNSAKQDGELELLVGGGCDKSKGYFVQPTIYETTNPQHKFLSTEFFGPLLTVYVYDDAAADGFERACALVDSTSDYGLTGSVFAADRQAIRQAEEALRNAAGNFYINCKSTGAVVGQQAFGGARASGTDDKAGSGNLLTRFVNMRAIKEEFGETSRVAYPSNEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0M5</accession>
    <name>A0A367L0M5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 11">Glycylpeptide N-tetradecanoyltransferase</fullName>
            <ecNumber evidence="5 11">2.3.1.97</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L249_7815</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>N-terminal glycyl-[protein] + tetradecanoyl-CoA = N-tetradecanoylglycyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15521"/>
            <dbReference type="Rhea" id="RHEA-COMP:12666"/>
            <dbReference type="Rhea" id="RHEA-COMP:12667"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:64723"/>
            <dbReference type="ChEBI" id="CHEBI:133050"/>
            <dbReference type="EC" id="2.3.1.97"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the NMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.97" evidence="5 11"/>
    <dbReference type="EMBL" id="LKCN02000022">
        <property type="protein sequence ID" value="RCI07978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0M5"/>
    <dbReference type="STRING" id="1330021.A0A367L0M5"/>
    <dbReference type="OrthoDB" id="60315at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004379">
        <property type="term" value="F:glycylpeptide N-tetradecanoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000042">
        <property type="entry name" value="Glycylpeptide N-tetradecanoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000056">
        <property type="entry name" value="Glycylpeptide N-tetradecanoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000903">
        <property type="entry name" value="NMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022677">
        <property type="entry name" value="NMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022678">
        <property type="entry name" value="NMT_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022676">
        <property type="entry name" value="NMT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377:SF5">
        <property type="entry name" value="GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377">
        <property type="entry name" value="N-MYRISTOYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01233">
        <property type="entry name" value="NMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02799">
        <property type="entry name" value="NMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015892">
        <property type="entry name" value="N-myristl_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00975">
        <property type="entry name" value="NMT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00976">
        <property type="entry name" value="NMT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase N-terminal" evidence="14">
        <location>
            <begin position="157"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase C-terminal" evidence="15">
        <location>
            <begin position="324"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="45"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048276"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCI07978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="540" mass="60893" checksum="5458CA4430ED5295" modified="2018-11-07" version="1">MPTEESKPAENDAPAESKPAPAEDSDHDEPRASSKSKKKKKRNKAKDILKHKSGAESEADIKQAIGGLTPQQTQDLLALNPSLAQELSQATSSSNPTAEQATDLLRKLKLNDIMTGLAASGKNVKDMGAYKFWETQPVPRFDDEDGSVEEGPLSTFTVDQVPKEPKPLPNGYEWVTLDLVNEEEMKELFELLNKHYVEDDEAMFRFNYSPEILRWAMMAPGWHKRYHVGVRASQSRKLVAFISAIPVRLRVRTRTVLCSEVNFLCIHKKLRGLRLAPVLIREITRVSNINDVWQGVYTAGVVLPTPISTCRYFHRAINWQKLNDCGFSPLPPGSKPQYQVRKYALPDETSTRGLRAMKAEDVDAVISLLGRYLARFDMAPEFTREEAMHWFIPKADADQVIWSYVVEDKDKNLTDFFSFFCVESSVINNSKHDVIRVAYMFYYASDAGLKQPPDRSALKSRLNSLVNDALILAKRAKLDVFNALTLMDNTLFLEQQKFGPGDGQLHYYLFNYRVNRIAGGVNKRNQLDESGGSGIGLVMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0X1</accession>
    <name>A0A367L0X1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_6218</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCM10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0X1"/>
    <dbReference type="STRING" id="1330021.A0A367L0X1"/>
    <dbReference type="OrthoDB" id="273123at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040184">
        <property type="entry name" value="Mcm10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055065">
        <property type="entry name" value="OB_MCM10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015408">
        <property type="entry name" value="Znf_Mcm10/DnaG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13454">
        <property type="entry name" value="PROTEIN MCM10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13454:SF11">
        <property type="entry name" value="PROTEIN MCM10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22379">
        <property type="entry name" value="OB_MCM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09329">
        <property type="entry name" value="zf-primase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MCM10 OB-fold" evidence="10">
        <location>
            <begin position="306"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger Mcm10/DnaG-type" evidence="9">
        <location>
            <begin position="452"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="79"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="261"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="500"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="668"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="508"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="668"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="690"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI08083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="720" mass="79592" checksum="D241F8A75052D1E8" modified="2018-11-07" version="1">MKHGGSNAIGIKDRDNIRRIAATHLRKARSIRVSYRVGLIGSRDTFLDGTGPPGIGIRNGHTTLRSTDELGQGACAEPMTSTVQSQRQSRHVKTGTDGISKSASALPQIQVPASPVRRAPPPQQQKSPSRHSFGIDKSLTMREVSLKRAPTQRSGREHAASHSQGFLERRRALNVSTASSSTSTTKTVQGTQRLLSYNERLSASRTAEAARAQRQERVQKKRSNAFGIGQEEMEEYKKNAIEMSDDGPANAPTFTRQEVLSQGNLPKSMTTPNLGSLPSKSTDESDSFPEKPSDAAQAESSPFEPYSCFHLSRRILPHRVLARHVSGKNSLSLKDLLKTVKAPDYSLPDVDQDMVVFAILARKSEPRSHSHQASANKRTPEGKYMVMTLVDLKMEVELFLFRSGFTRFWKLTEGTVLAILNPTVMPPPPGRQDTGRFSLVINSDADTILEIGAARDLGFCRSLKKDGDVCGGWVNRKRTEFCEFHSNEAVRKQRSKRLEVNSGGFGGRKPDSRELRKPTNNNYDWETKTKWFASRSHSAADLIDGKNRTATDKKEREDFLRRSLEAKEREREIMRKLGRVGNAAGKEYMLMRSAGCRTSETTDVGDAPTAKGRLGEAAAISLGLHKGKDRAIHLSPIKRKRPQSSLASPSLLARPGYGWGSSLKEKLTKMREGDEAPREGKSPTRKKTRFVTDRGIREAGRDSLGKEADIGEDDELIIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1B4</accession>
    <name>A0A367L1B4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal protein L5 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_6306</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1B4"/>
    <dbReference type="STRING" id="1330021.A0A367L1B4"/>
    <dbReference type="OrthoDB" id="539541at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_uL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_uL5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_uL5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_uL5_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="RL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL5 N-terminal" evidence="5">
        <location>
            <begin position="194"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL5 C-terminal" evidence="6">
        <location>
            <begin position="254"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI08215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="41107" checksum="B49E1F72EA04B29B" modified="2018-11-07" version="1">MAAAARDGLRVARALGRPCAPTITPALRRRAATAAKSSPDWTDLESTSSFTSPAPGPELVKEFDEANQKRWTAMENRELKLPGNRYQYHPPKFYRGPLHPIQIPKPSDSIARDFVPGPFNYPRLKHTYESTIAADLVTLNYSHVPLGTVVPKSRKGTLRSWDDSSPYFKNRPLRRPRGTSSSRQALVERKISWHNIPEIRAVTLHAFAPLSGSDKEYLHVARAVLQAISGQFPDVTSIKTNVSQWGIKKGKKGGAVVTLRGAQAYEFVDKLVTLVLPKIKDWPGIKGTSGDSSGNLGLGIEPQWMLYFPEIEYNYDMFPEPLVPGLHIIMHTSATSDRQGRLLLQALGFPFYDVRKKGRTNAGLRQWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L208</accession>
    <name>A0A367L208_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">HTH APSES-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_8881</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EFG1/PHD1/stuA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L208"/>
    <dbReference type="STRING" id="1330021.A0A367L208"/>
    <dbReference type="OrthoDB" id="5407653at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.260.10:FF:000003">
        <property type="entry name" value="Ascospore maturation 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029790">
        <property type="entry name" value="EFG1/Phd1/StuA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47792">
        <property type="entry name" value="PROTEIN SOK2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47792:SF1">
        <property type="entry name" value="PROTEIN SOK2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0183">Conidiation</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0749">Sporulation</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="10">
        <location>
            <begin position="186"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="299"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="452"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="392"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="497"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="532"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="614"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI08446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="686" mass="72384" checksum="68DF478A07BBD56B" modified="2018-11-07" version="1">MSTDGLPSLPPLPLPSQAYSSGTSSPRVSSIASHAGSQSSFTSAASSNGPKTPSPTLPADAIAAAPHSGIVAYDAAAMNQGADMYYPQHMSAGQAPPPHTVTSGAMTHYQQPQPPLLQSGHAQYPQYGGYGYTNGLTSPTTATAVSNSMAASQNVLPMPGGPGNIQTQYANFDTTGQHPPAGMKPRVTATLWEDEGSLCFQVEARGICVARREDNHMINGTKLLNVAGMTRGRRDGILKSEKVRHVVKIGPMHLKGVWIPYDRALDFANKEKITEMLYPLFVQNIGALLYHPNNQSRTNQAMAANERRKQEQGQLRNPPPQGLPSIQQSHHHHHSMTGLAGPQPSLPSQSHVAPRPPLDRAHTFPTPPSTASGVMGSMGPSESFGWQGQGMNGSQATTPPGTSMTSMQSYPSATPGYDNTRQMYNAPASQQSPYQTSANGTQDRMYTQNYAKSDMAPPSSRPSAGGTQGEQHDGKPPNGIMASEQTTQHSTGDDEADHEHDAEYTHDSGAYDASRTSYNYTAPGVGALASDGNISSEMTGSPNHPPASGRATPRTTAPHQPYYSQHAGYSTPPRVPSSSSLFNVAGSDRSQHGGASNTDVYAPASDIGGPMANNYASQSSIINGSAGSLKRGRDDDDMSRSTADGSTGGMTGLDLKRRKTVMETTVPPVYEALSRPASAVAAPPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2N7</accession>
    <name>A0A367L2N7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_4628</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2N7"/>
    <dbReference type="OrthoDB" id="4931002at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI08686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="438" mass="48976" checksum="DD125453DCB147C1" modified="2018-11-07" version="1" fragment="single">TRPEGLGGSRDAGPAAAGPRPPYVTEAERHNNVGGGYGTATPYSGYGRTGRTGRTKEGTATAAAAAAGLEGLFDYRLLRGGEDEGPALADLATFFFLPTAGELTADSTLFFFDLCGRYGYGYGYGKRPRCYSSSTAFSFPLERSLRPDFFGCFFRPLVFRPFLPSLFFLRSALQPTETTGTGLGSGLGIRVRAGNSSYNSRYNNRNNSSIRTYLRPYRTYAPYSRYLRPQSFVVLFFVVFFFVFSFLRPYPPLRPFQGRGIQQFLDQFEEQVLDRRVDWLPFFVAPPCLRQIQVLTEDLPWPAAKTALLRYYGAFDQIRTVGFYEKLRRHEARRPKTKDTIDWLEKHAFFCRKVGPGPSPGPDESTEHSYGLFQALPKEIQEGHVTPGRLQPARGRRTSQRLYVTAAVRGGYGYGYGTATPYSGYGRTGRTGRTKEGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2U9</accession>
    <name>A0A367L2U9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Signal peptide peptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_4708</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase A22B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2U9"/>
    <dbReference type="STRING" id="1330021.A0A367L2U9"/>
    <dbReference type="OrthoDB" id="29661at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098554">
        <property type="term" value="C:cytoplasmic side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098553">
        <property type="term" value="C:lumenal side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033619">
        <property type="term" value="P:membrane protein proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007369">
        <property type="entry name" value="Peptidase_A22B_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174:SF23">
        <property type="entry name" value="MINOR HISTOCOMPATIBILITY ANTIGEN H13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04258">
        <property type="entry name" value="Peptidase_A22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="289"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="439"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="468"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="54"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="528"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="528"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI08760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="577" mass="63284" checksum="49ED46DD827AF2C9" modified="2018-11-07" version="1">MSTEPTAPPGVNATQPSTSILEFLQDRHFLFLELKLLAGAAGIIYVGAHASLRRPPSASPVVKSGKKNGQGSDKDLEEGDDEEEAPISQGLELSDAITFPLMAAAMLIGLYYLIQWLQDPALLNRALRTYISVMSLVSLTTLFAHILEVATSLAFPTWWRGSDGLLRKVSQKARAVIVCDDVGNAMVGRNSDDSVGPLPAFLAFLTPLAVLRRLAWDARSVLTRRWLFRLYVHGVGNNRYGVRLTHVVAIVLSSVTAVVYFWLPSAFLSNLLGYSLCYGSLLLLSPTDYLTGSLVLVGLFFYDIVMVFYTPYMVTVATQLDVPIKLTFQSAHRRSMLGLGDIVLPGMVMAWALRLDLYMHFLRKVKYESAELQIVERDTASGQVTTRTETKHKEVKARYVNVKGRWGDVLWTAGVGAFFSCGPRRQLPVELAAANFRKTYFYAVMAGYVSGLVVTLAMLLVFQQGQPALLYLVPGVLGSLSATALVRGEMGDVWKYTEDGSLDTVDVVVDLDAEGKVMKTVGKAEDGVVDTSRSDSDKKKEDDADAGGGSKCDKRRETEEGRGLVLVTLDVRDLEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3E3</accession>
    <name>A0A367L3E3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5136</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI08944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3E3"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="69" mass="7366" checksum="B0BC29A66FEDBDB3" modified="2018-11-07" version="1">MGGAAITERCGYGDGIGSTAGCDRKNHFAVSHYLQATASAGYSYRLPGMPINDDDDEDDDDDDDDDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3F0</accession>
    <name>A0A367L3F0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_5075</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI08955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3F0"/>
    <dbReference type="STRING" id="1330021.A0A367L3F0"/>
    <dbReference type="OrthoDB" id="3248909at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021840">
        <property type="entry name" value="DUF3433"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544:SF3">
        <property type="entry name" value="SPRAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544">
        <property type="entry name" value="SPRAY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11915">
        <property type="entry name" value="DUF3433"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="279"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="327"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="558"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="603"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI08955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="725" mass="80197" checksum="ECFA91CE7ADC0FF8" modified="2018-11-07" version="1">MRANRHRRLFAQDAQGQGQGEEAYDLSLLRAAAPIAYDEPPPPPPVVFDVTSALGPLATQDVDFIKKLQAHEANVRDADLLRQSTNRSKTSFRRRQTLREAGQHEANRRGRIVEVIAEQELEQQQHDISNFDGPSHARFHRRRRRRRPATTTRVFYPQPDWRPPSMGWPYLSLLVLVSVALAAGSEMMYHVHADRPLVRFTSAAELSTGLYVAVRFAPSICAVTYGVLWQLVDLDVRRLEAFHQLSRRAGAEAAASVNVDYLTGYTLLRPLCALRRRHYAVFVSSLAAIMAASLVPTLAAASIVLTPSRAERRADPAAWKMLLLSAIWSRLLTATLVACAVAGILLLRILQSRRSGLLADAQGIAGLASMAVVSHILMDFRRLDTASLGDIHRRLKRKRYVLRNSSLAPRDEVDRDDDDDDDDDDDYNHDSSSSDSSSSDSSSSDSSSGKPPSESPHPLILRPIGWLPFLAGSVALMAMMPAMLFTNADVILDRAPWAATAAAVGLKLSWNAMETAVRVMEPFYILSRRHAPAKTLLLDYTAQPFGWLPAKALLNQHWLMLAVGVGSLMMEFLTILVSGLATVDGQELAARNQAADTGQETPTTFYSSLALCEAVLVYAFVIGAVVFARRRSAFLPRQPTTMASVLAYVHQSKMLYHFVGTEAMGAPELGRRLDLLGKTYGLGWFTGRDGQTHCGVDEEELMGSYRHGVDDSQRNQPWNTAWDVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3P6</accession>
    <name>A0A367L3P6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA mismatch repair protein HSM3 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4931</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI09037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3P6"/>
    <dbReference type="STRING" id="1330021.A0A367L3P6"/>
    <dbReference type="OrthoDB" id="4538483at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="36879" checksum="A7D81945EA148EB7" modified="2018-11-07" version="1">MADDIIVPLRSPTAPISGLPELQAHVEALSNDPSSPPTQSSSTKLTIPYPDQNIRPLIPILLPRLAQLLKTQTEHDPSPLLSLSIKLISPLSLAQALTFADRTSLLNALRSPLPAANLLALAIVGKAASSPAEAERLAELPDIVTELLRLWLGSPDVGVGEGAARVLARVLETDCSSAEVVNGTGHEPRPPGRGRIWPIILEDDDNLALIRHLCTLGHDPCRLTYDVTISQGRLLRLLPTLAALDMQPLTAETGQGLLQWAALSMVDTSDTLMHLSLVDFYESLVGSMRQSRHARDATVKSLVNKAAREDSAVNNALRTLADRVEDDDDAPDVRNYVAYLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L419</accession>
    <name>A0A367L419_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphoribulokinase/uridine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1506</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L419"/>
    <dbReference type="STRING" id="1330021.A0A367L419"/>
    <dbReference type="OrthoDB" id="6362633at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribulokinase/uridine kinase" evidence="1">
        <location>
            <begin position="26"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="231" mass="25880" checksum="D41E793F8FC1FA5B" modified="2018-11-07" version="1">MDAQVERLVDKTWSRYQALAPGHRLLIGIAGIPGSGKTTLSKTVSKQINDRASNDVSIYLPMDGFHLTRAALSAMANPSEAHARRGASFTFDAPKFLSLVRALRSTPIKPSAPVLAPSFDHAIKDPKEDDIAVQPWHRVVILEGNYLALDEHVWRDAASLLDDLWFVDVDEEVARRRLRERHVRAGIARHLDEADRRVTENDLVNGAEIIARRLPVNEVVCSEEDDEWAHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L429</accession>
    <name>A0A367L429_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">catechol O-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_1462</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.6" evidence="1"/>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L429"/>
    <dbReference type="OrthoDB" id="186626at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006584">
        <property type="term" value="P:catecholamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43836:SF2">
        <property type="entry name" value="CATECHOL O-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
        <property type="entry name" value="4HBT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0128">Catecholamine metabolism</keyword>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="431"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI09186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1092" mass="121515" checksum="B8EB9F6B535D7EDB" modified="2018-11-07" version="1">MAGFEASKAYVAQEDVYYDDGREVRLLHHIYSRPDLDRIRGSPEKVLDAIDHYGRTVAYLMNVGEHKGDIVRQLILETKPEVMVELGGYVGYSAILFGAALQRAGGRQFLSLERNPEFAAVASSLVDLAGLSPLVKVVVGPCQDSIRRLHSAGQLRLIGVLFLDHWKPAYVPDLKLCEQLGLIQPGSVLAADNVIKPGNPPYLEYVRSSVQDKKKGIAAHTGTGSFDKKWVEMYEKREGVEKLDVTARGDPCLVYTSKLVESFEPTGVPVRHCGDFVSSTTVIVAVSVWNRLTPRKEPTSSSSRKTVLVTGVGMSKGLCLARLFHRAGHRVIGADCSALSPGRVSAAVDRFRKLPKPASFSADESGRDPYVLQLLEIVRSERVQLWVSVSDVSAAAQDAVARDLIEDRTTARAVQLTFADVQTLHDKDSFMRYIQSLGLPTPDTDVVASRAAVVEFLMRRGGLELKPGAGQYLLKPIGVNDLARFNMPLLPLSTTAETMRRIDSIPMDGAPSFIMQEFVSGPEFCTHALVIRGRVRAFVACPSSGLLMHYEALPRDSQLSKRMLALTETVAKAGGPEFTGHLSFDFILKAKNEELYPIECNPRVHTAIVLFNDTPQMVDEYLTVLEPASAGSGEELSPNLPRRYYWIGQDLVQKAIGSPSRSKLASFVHDVRHSKDGTFEAWDPWPWWLLYHVYWPLQFIALLVRGERWTDRRNGDEDCAEIVGFIIMVVVNSSSCYATAPPSPPSSASSAPYPSGSSPKAGGLITAVRVLVPAAVVSVGYTAYRIDWHACYVALTTGPNRKWRWMQILLALLSWKSLPLVWTWRIFYAMMYHSVFAKAPPHTPRFLFKPMVNESHVTLLEMDYNLHKSNSTFFTDLDCARTHLVSYLCRRGMEKLRHNRRDALVPDPTTGLPASGPINIMLGSVACSFRREVGAFTRYEMWSRIIAWDRKWLYILTHFVPKGTAKPAEWLDRRCAGLKTNKAATSAADWEKKIQATALSKYVFKLGRLTVHPAIVLERSGLLPHRPDGWISGKDVSDADDGDQVGSNNEEWHWHRVEAQRKKGMEMASKFQALEDMHDLFDGGSDGALGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L489</accession>
    <name>A0A367L489_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_1407</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L489"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF55">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17480)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="249"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI09237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="422" mass="45403" checksum="D29211D70E8C6D16" modified="2018-11-07" version="1">MYNALAGLGGCGQVDSSVAANATVAMLCTMAITSLFVAGPLFAWAGPRLSLMAGGWTYALYSGSLLNFNRTGNGAFVIASGALLGIGASLLWIVQGTIMTSYVDESRKGRAIAIFWVIFNLGGGIGSLASFGLNYDSEKGSVSSATYAALMVVMLFGWCLGLFLCSPSRVVATPSPPAYEEKQREEAVPPKAWREMAMDTARLTIQVLYTWRVACMLPLFFSANFFYSYQQNTVNGDTFNIHTRSLNGASYWLSQMAGGLFIGLILDLSVLGRRGRARLGWSIALVLGLIIWGGGYQFQLWQNERLARNQRQDVDFRDASLAAGPMALYAFYGAYDAIWQAFAYWLIGTESNSPARTAILVGAYKGLQAIGGSIAFRVNATSLDSMTELAVNWGLCIGSLIIVLPVVWTVSASSADESESES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4L8</accession>
    <name>A0A367L4L8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000015">
        <property type="protein sequence ID" value="RCI09374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4L8"/>
    <dbReference type="STRING" id="1330021.A0A367L4L8"/>
    <dbReference type="OrthoDB" id="2565331at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40636">
        <property type="entry name" value="CSBD-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40636:SF1">
        <property type="entry name" value="CSBD-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="96" mass="9067" checksum="E487947AED5C8984" modified="2018-11-07" version="1">MFSKDSSSNTTGDKATGAAKFVTSTLGNTVGGVTRTAGTVTGAATKGVGDTLTGVTGDLGKPIGDAITGVGAGVESGTGSLAKGAENAGEWKTGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4T8</accession>
    <name>A0A367L4T8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Diterpenoid pyrone biosynthesis cluster protein C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_3719</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000015">
        <property type="protein sequence ID" value="RCI09446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4T8"/>
    <dbReference type="STRING" id="1330021.A0A367L4T8"/>
    <dbReference type="OrthoDB" id="18170at2759"/>
    <dbReference type="UniPathway" id="UPA00213"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000008">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1780:FF:000001">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1780">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048:SF28">
        <property type="entry name" value="4-HYDROXYBENZOATE POLYPRENYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PRENYLTRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00075214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI09446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="316" mass="35469" checksum="2CE6049AED378BFB" modified="2018-11-07" version="1">MTDTTASGHVTRHLFALSRFNKYNPLFTTFAGAWSALLAGAADLASHRPSVSLLFVLRQTALCFLAAYLFCGAGMVWNDYVDRDIDANVSRTKDRPLAAGKITTAQAMVWMVFQLFLSWLVLDVMLDGKDVWKHLLPVIIASFLYPFGKRPAARMVYIYPQYILAFTIAWPAVPGRASISGRHDGPFTETIRQCLPICTTVFFWTLYLNTAYSYQDVVDDRKLKVNSFYNVAGRHTRALLVALVSPILVCLPLHLAQFRSPWLWISWMGVWTAALTVQLLRFDPKRPASGGSLHKSNFVLGLWTVVACVVEVLLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5I2</accession>
    <name>A0A367L5I2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DAGKc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_3795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5I2"/>
    <dbReference type="OrthoDB" id="3853857at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001727">
        <property type="term" value="F:lipid kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF108">
        <property type="entry name" value="DAGKC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAGKc" evidence="2">
        <location>
            <begin position="97"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI09482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="476" mass="51949" checksum="72714D9DDE6DF719" modified="2018-11-07" version="1">MDPPSTDDVAPTRVTQILIRNDSSLVWTRSDGTQGTATTNSVLFVLNLTASSRGFVTCLLRESSVDGACPQLLLLSTQDPPPSQVLPMIRQLPPQLDKDTEVDVVVSSRSGTGLGPPFWRTVLRPLLHLVCGALGGGVPKEAFLTPDAQAVKRFGTELRGRTDGSRLVVILSGDGGVADLLAGYGVEEAVTKPVIALLPLGTGNALFHSLHRSPSSSSSSDPSSPAPLVQGIRTLFLGSPAQLPIFRATFKTSTEEEEATTLHGIVVASYGFHASLIHESDTPEHRAQGSKRFSIVAESLLAEGHEYEAEVKVDDEEDEEEDEEEEEEEEEEEEQQQQQQQTRAKKHGYVLISMVSNLERTFVISPESKPLDNRLHLVRFGNLDAGRVMDVMRGAYQGGKHVGMRWDDGEEVTYREVDEVRVRLLDEHRRWRKVCVDGTIVDVPRGGSVTISKTGARPFRILVDDDALAPSTTAVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5J6</accession>
    <name>A0A367L5J6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L249_3978</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5J6"/>
    <dbReference type="STRING" id="1330021.A0A367L5J6"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05684">
        <property type="entry name" value="S1_DHX8_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000061">
        <property type="entry name" value="ATP-dependent RNA helicase DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000101">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000191">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049621">
        <property type="entry name" value="S1_DHX8_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF85">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="190"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="499"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="688"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="133"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="287"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="412"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="85"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="158"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="412"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCI09694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1154" mass="129156" checksum="24CA17B817EE5248" modified="2018-11-07" version="1">MDDVSNLELLSLVSKVTSELQNHAGTSDKTLAEFLIFQRVKSSSLEDFRKWLDTVKNPFPESFVNSLDRLVLTLHPKFKGNAKPSDGDEHRPSRTLEDKEKIFSGLALPDEKNGGGGGGDAIDDTLAMLEGLESKTKTGPPSKKRRRSPEDDPTDRRNGHRGSRKARRHRSDARIDRSPEPEVDETPQMHKIYKGHVTGIKDFGAFVSLHHVRGKVNGLVHVSRLSAGQRVSHPSDLLSKGQQVFVKVFSIEGSRIGLSMKDVEQATGIDLEPQSRFSTGANMEALGGGKRRGFGENVPAMPRDGVGPPTRQKKRMTSPERWEIRQLIASGVAKASDFPDLEEDYNATLRGDGELELEEDVDIEVRDEEPPFLAGQTKQSLELSPIRVVKAPDGSMNRAAMAGSVIAKERKELKRQEADTKEEPKENLSSQWLDPMADPDKRKFASDMRTARMNPKPEEVPEWKKAVIPRGQSLGKRTNLSIKEQRRQLPVYAFRSQLIQAVKENQILIVVGETGSGKTTQLTQYLAEAGFAGKGGIIGCTQPRRVAAMSVAKRVAEEVGCKLGDAVGYTIRFEDCTSPATKIKYMTDGMLQREILMDPDMRRYSVIMLDEAHERTISTDVLFALLKKALKRRPDLKVIVTSATLDADKFSAYFNECPIFTIPGRTFPVEILYSREPESDYLDVALLTVMQIHLTEPKGDILLFLTGQEEIDTACETLFDRKKALGPSVPDLIILPVYSQLPTEMQTRIFEPAPPGSRKVVIATNIAETSITIDEIYYVVDPGFVKQNAYDPKLGMDSLVVTPISQAQANQRAGRAGRTGPGKCFRLYTEAAYQSEMLPTTIPEIQRQNLAHTILMLKAMGINDLLHFDFMDPPPVNSMLTALEELYALSALDDEGLLTRLGRKMADFPMEPSLAKVLIAAVDRNCSDEMLSLVAMLNVPTIFYRPKDKQQQADQKKAKFHDPHGDHLTLLNVYNAWKRSGFSNPWCHENFIQARSMRRAKDVRDQLLKIMDRYRHPVVSCGRDTQKLRRALCSGFFRNAARKDPQEGYKTLIEGTPVYLHPSSALFGKHAEWVVYHTLVLTTKEYMHCTTSIEPKWLVEAAPTFFKVAPSDRMSKRKQAERIQPLYNRFAGENDWRLSAQRRGGRGGGGSTWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5K7</accession>
    <name>A0A367L5K7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2-methylcitrate dehydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_3952</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5K7"/>
    <dbReference type="STRING" id="1330021.A0A367L5K7"/>
    <dbReference type="OrthoDB" id="10055203at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047547">
        <property type="term" value="F:2-methylcitrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019679">
        <property type="term" value="P:propionate metabolic process, methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.120:FF:000001">
        <property type="entry name" value="2-methylcitrate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012705">
        <property type="entry name" value="2Me_IsoCit_deHydtase_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006943">
        <property type="entry name" value="PRK09425.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02330">
        <property type="entry name" value="prpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943:SF16">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE/PrpD N-terminal" evidence="3">
        <location>
            <begin position="63"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE/PrpD C-terminal" evidence="4">
        <location>
            <begin position="327"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI09715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="532" mass="58797" checksum="EBAC4683CAE9DB60" modified="2018-11-07" version="1">MSAARQSLLRTTASKRLRPFSSLPPSRILAIRSASARSSFTTSAVRTTAMTSSYLQRFDGEIQDIADYVANKNIDSELAFSTARSILLDTLGCGLEGLRFSECSKLLGPIVPGTVVPNGTRVPGTPYVLDPVNGAFNIGTMIRWLDFNDCWLAAEWGHPSDNLGAILAVADWVNRTNQAGTGSTLAGGRTFTGIQGCLALLNSYNRVGLDHVLLVKVASAAVVSKMLGLEQSQIADAVSQAWVDGQSLRTYRHAPNAMSRKSWAAGDACQRAVNLALRVLKGEKGIPTVLSAPTWGFYDVLFKGKKFQFQRPYGSYVMENVLFKVSYPAEFHSQTAVEASEKIHHQLKKMGKSAADIKSITCRTHEACVRIIDKQFKPMENFADRDHCIQYMCAVMLVFGRLTAADYVDGSEAATSDLVESLRQKIKCVEDPQYTKDYHDPQLRSISNALTVTLNDGTFLDEVAVEVPLGHRQRRQEAQAAIMAKYRRHLAPHMPESRVEELVKLHEDHGRLDSMPIDKYVDLYVVKDSKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5M6</accession>
    <name>A0A367L5M6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">MYND-type zinc finger protein samB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_3940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5M6"/>
    <dbReference type="STRING" id="1330021.A0A367L5M6"/>
    <dbReference type="OrthoDB" id="5424793at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="133"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="262"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI09522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="471" mass="51214" checksum="735B53BB16626546" modified="2018-11-07" version="1">MQSPSIHALPEHWTELSAAKRQRKLCAEDVKALQRSCSKECGKKKVTECTNCYGKALDRMRKRYTESREREWFSQRRAFLHELEGLFQEAKEGKRSLESIEARIESEKEAWYRWVLRRYPEFIAVAEGGGGGAAAAGGGGGGGASSSSASSQDDLRSMLDDPDRSRNELVNMMLRGVGAPPGGPSAIEAFAEKVSASDRDKASLKTLYLSEFFSSEEAGSARKYLDGYRTGNNDEDNSSSLEDVIDAIVSDLKQSRASQPARTAQQKRLDELRRAKTAFEQNKSQVRSQALSRRAAANAAAAVAAAAVREELYDLPPCSVCRSPVPASGVLSCSLCQAFAQLGGDGMMTVYCSESCLAKGHNDHIDKAHVCEAGDKCLQLQATTTTESQEWKSTTCRSCVEQSRRIPLYCSESCGRKNHLPPPSSTCSSSSSSSSSSSAHHQDLVPIKSFLPQVLADANPGLFMSRFETSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5N0</accession>
    <name>A0A367L5N0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_4097</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5N0"/>
    <dbReference type="STRING" id="1330021.A0A367L5N0"/>
    <dbReference type="OrthoDB" id="4927048at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI09708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="239" mass="27368" checksum="C270D6DE37CA609E" modified="2018-11-07" version="1" fragment="single">REEAPKCANSSRALVFEKDMNINRKTRHRGNFDTPYKVWRALIRPGDWTRYRQDQVSSVCQKGTKPWPAVQRCSSLDGLRVELRMGTGFVNLMDYAGTYDNLVLQIGQDAFILAEHPDSGEKTTKTVDLKKAFGSESVRIRDIESFRLFPVTGQRVNADRWKVEGSIIGSITFEGRCEASSMTARYEEYGSVNRWFNRFGRLQRGGRQEETELRGPISWTKWKFSEHKGAATAHDGSEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5Q1</accession>
    <name>A0A367L5Q1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phytocyanin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_4139</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5Q1"/>
    <dbReference type="STRING" id="1330021.A0A367L5Q1"/>
    <dbReference type="OrthoDB" id="5421909at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00920">
        <property type="entry name" value="Cupredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031305">
        <property type="entry name" value="Casein_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF15">
        <property type="entry name" value="EXTRACELLULAR SERINE-RICH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00306">
        <property type="entry name" value="CASEIN_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016677699" description="Phytocyanin domain-containing protein" evidence="4">
        <location>
            <begin position="21"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="171"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="139"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI09753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="20286" checksum="977013DD00C52AAD" modified="2018-11-07" version="1">MPSFIRNCLLASALAWAAKAETIRVTATSSNVFSPDTVTAKQGDSIEFHFQAQNHSVVAGVYENPCTPMALGSGFFSGFMPVEGGGEAKQVFRVNVNSADPIPFFSSQDDECPHGMVGIINPSGDKTLDKYRNQAKSLSRAVSPSGSSYGGDLADNNDPSVKKNPDGTARAAASAAAVPVAAMAVAGGVAVMAVLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L683</accession>
    <name>A0A367L683_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exocyst complex component EXO84</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Exocyst complex component exo84</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L249_4116</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Plays a role in both the assembly of the exocyst and the polarization of this complex to specific sites of the plasma membrane for exocytosis. Also involved in assembly of the spliceosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the exocyst complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
            <location evidence="1">Secretory vesicle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EXO84 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L683"/>
    <dbReference type="STRING" id="1330021.A0A367L683"/>
    <dbReference type="OrthoDB" id="642193at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000264">
        <property type="entry name" value="Potential exocyst complex component Exo84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1220">
        <property type="entry name" value="Exo84p, C-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1210">
        <property type="entry name" value="Exo84p, N-terminal helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033961">
        <property type="entry name" value="Exo84"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032403">
        <property type="entry name" value="Exo84_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042561">
        <property type="entry name" value="Exo84_C_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042560">
        <property type="entry name" value="Exo84_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21426:SF12">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16528">
        <property type="entry name" value="Exo84_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25345">
        <property type="entry name" value="PH_EXO84"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst component Exo84 C-terminal" evidence="14">
        <location>
            <begin position="454"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="662"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="666"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00057052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00065378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00071741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCI09732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="699" mass="76517" checksum="E56F97F993423745" modified="2018-11-07" version="1">MSDERSKISLRSGPKRKGRPTISAPRQISSPLSHDGGLKPGESAPRARLRPAPMAGGKTSNLVKQRYSTRFNNPPVGLDAGIPPPMPALPSTMDRRAGMMTKKTTTAAPRIGAAPVVDIKALRDPKLVPDQFVSAMLGDATEHQIHDFEESLRKIKTRAAADLQHSLMQNRSQFIKISKEADKLKGEMRALRNLMADLKTNTDALRAASSKGDESSSAGTFAVGLSKRDKRSSVADRSALWNSQMQALYKNVEGSQKFLPNAAGRHVVQNAGPWVELDNATYKSRRAMQIFLLNDHILIASRKKRKADVDARSGGPVVKLVADRCWPLLDVEVVDLPGSTEPPPSSLVSPTSSGRNKLADAIMLRGGGHESFIYRTEKPQDPEKRTLLLNVRKAVEQLRKGLQSEMEANNKARETINYFASRDPGLLQKTELLETLSDIKDMLVDVDGKQQNLRWVEGQMDELDIDIALQRFEPAVALVEKLRGLARSLRSNYVARDFVNFKVDERGARLAGVIIRELETTHSEQGKTKRNVGWLTRLGFEDRAREAYLVARSDIIRKRARQCVFKGDLHLYIWQLSFVYFTIIHNTVQCFQACFPPPMMSACVRWAKEEVDAFNAILARQLSSTERGGPVWTQCMERAKEHGKKLSQVGLDFEGLVGRGVDGEGDGGGSDGGGGGGDGGGGGGGEAVTSPVGLGLAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L720</accession>
    <name>A0A367L720_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_8724</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L720"/>
    <dbReference type="STRING" id="1330021.A0A367L720"/>
    <dbReference type="OrthoDB" id="3439035at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="719"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="541"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="626"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="842"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="878"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="541"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI10227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="898" mass="98652" checksum="FF08D8E74CAF92F4" modified="2018-11-07" version="1">MNNKNAFNPAQKLPFSRDGRPPLYTTTATSKKMPEPARQDDGLPPPPSPRDTRIPRRRRHESITEAFKKAKEEYGIFDGSPSPAPKQWRNSEGGGGGAAAIMPDLVPGIQDMPLPSVEQAPRPAIPIGPPEEDFVWDIENDFTAGDLQVSDSPRIKVDMNRPFAHRPSLVAGAKLPATKRPPWGSNFYKGPITRSNSKMDEILAREMQHMSMNEADRSKPRPKNAKIDEIRQREAKMLSKRAYAAGRLEEIHEQNFDSRSVSPLETSAPKPTSAGEKMPNMPVTVFRGAAQDGRAASRRAPVDDDANGEGDDKPGDARDLLRRLARATSASPGPDTEQAQRKPRDQGAKPKVVAFTGLRRVDSTESAKSKASLRSDADPTDRIDAEIRLFAPQENQSEQGSVRAPSPPSNEETAKTPTQQQQQQQEQQARDMMLEMPRVTGAFVETPATRRRRGSDTDADGRPATRARTRESDTASDPGTSDGHVAAREPTLKKRHRARSLPRRRLPIRNSAKPPSVREDLLELQRTHNIDDSTLEDIDKAAAAPAATDDSSTTATVTTKRRSEPVRPPQLKAQPPKQAKENAVEADEGRSVLGRLLLSTLESTKAVRKGIDRLIVASASSMTRRVEAVGGDGQAATGEEEHKSMPAKSEQDNNGFFHLTTATGKDGSNSPGMATIILDRCPSCQAHLPPSARQESASSSPVTYLQVPVPRLYQTMPRFRLTLAGLLLFFLFLWLAAESTMCGLYCRPKRCSAGSECVFSLDDPHFGTALPTKLDQWTTGGLGGRILATAAEETVDRLADLQDLATGRETLLEAGDQELSLLGMSARQKRRLRRRLAKRGLGSPFATSKSKSQWDEAEEPSAEQLAKWEAWRRVRAERKRARRMGGTSLGDDERVEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L739</accession>
    <name>A0A367L739_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_8704</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L739"/>
    <dbReference type="OrthoDB" id="4927435at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.20.10">
        <property type="entry name" value="Crystallins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011024">
        <property type="entry name" value="G_crystallin-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49695">
        <property type="entry name" value="gamma-Crystallin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016578667" evidence="2">
        <location>
            <begin position="25"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI10246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="414" mass="46247" checksum="B806FF7935D93BDE" modified="2018-11-07" version="1">MRGHHPILPAVLLTIFAFVPDRGALSLPQQAPRAWKFIHPSNPAVAEVRKEPWKLPLSPLPPPVLTYSPLLLLLPPPPPPPPPPQAVNASIDVSVEKSLRSPGASVKQVLYPSTVMFCEHSRYKGQCKEVAARHSHFCYEVPTELQRSVSSVKLINILGRCRFYKDFFCQGDFFETANSVGGIWDDHVRFHNSIYSFACNFPLPIFYPNIKFFGPQVAVDITSQGECAQVPSSIATIVSSLRIPEAIGSCRLYRSEDCQGNFIDAFDDIPVLRNVRDGFNDNIRSIQCPVPPPPSDKPHPSQLMEPQYIPARPLPPQVMPHPSIPSKSRPPRPAPSRTRPPKYGLARSGPLRDKSAKVVSPEAKSPEIVSPKPEPQQPEHMKLLPELDRSFVDQGCELVEDEDEDEDEDERVFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L741</accession>
    <name>A0A367L741_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_8502</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L741"/>
    <dbReference type="STRING" id="1330021.A0A367L741"/>
    <dbReference type="OrthoDB" id="4222821at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF32">
        <property type="entry name" value="ARGININE METABOLISM REGULATION PROTEIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="47"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="259"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI10042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="424" mass="45676" checksum="5B911F4B0907CE0D" modified="2018-11-07" version="1">MDGSKRRLERLACDRCHRQKLRCSRASSQSRACQRCVKAGERCTYSPPLRLGRPVSSNKQDKNGRSPRSSPSTTLRESRHSTPATCVEAGVPMAESVDLSGHATAPSASPTIVAIPEPQSSDFLMATASAMDKAFLLAAEDDYRHGMPMVSNMMLDIDYEQQQQQQQQQQQQLSAACDMDDFYLYGTTPCPPETVFEDGSPPGYDNDPERQLLMLQQNLLEAVMVDDVDGLEKTIGLTARAFNMLLGIMTALTSPSPSPSCSSSSESPPLLGSSHRLHSGDSGTTTILLITACYARILHNVDAIATRLHEMVSCCDHEALLALPCIQMGTFIPSTLVAPAIQTSVLVQILSQSVCEIEKRLPSLTCMLLVPPAPAVRGGTVGRSHVADMVGAVYGNVIHLEAHVKSVLGATLDLLTLAASKRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7B7</accession>
    <name>A0A367L7B7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DBF4-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_8659</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7B7"/>
    <dbReference type="STRING" id="1330021.A0A367L7B7"/>
    <dbReference type="OrthoDB" id="21380at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031431">
        <property type="term" value="C:Dbf4-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010571">
        <property type="term" value="P:positive regulation of nuclear cell cycle DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901987">
        <property type="term" value="P:regulation of cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00027">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3410:FF:000001">
        <property type="entry name" value="Protein DBF4 homolog A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3410">
        <property type="entry name" value="DBF zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055116">
        <property type="entry name" value="DBF4_BRCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013939">
        <property type="entry name" value="Regulatory_Dfp1/Him1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051590">
        <property type="entry name" value="Replication_Regulatory_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006572">
        <property type="entry name" value="Znf_DBF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038545">
        <property type="entry name" value="Znf_DBF_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15375">
        <property type="entry name" value="ACTIVATOR OF S-PHASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15375:SF26">
        <property type="entry name" value="PROTEIN CHIFFON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22437">
        <property type="entry name" value="DBF4_BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08630">
        <property type="entry name" value="Dfp1_Him1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07535">
        <property type="entry name" value="zf-DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00586">
        <property type="entry name" value="ZnF_DBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51265">
        <property type="entry name" value="ZF_DBF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DBF4-type" evidence="6">
        <location>
            <begin position="618"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="175"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="545"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="16"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="238"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="570"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="594"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI10318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="678" mass="74440" checksum="B9272BF4E2A83EE6" modified="2018-11-07" version="1">MAAVSLSPTPAAMSTRRAPLANNPNAANSPLRGASTLPCYAKQKRAQREDAYVQPPPVKKQALENGSQRAIRSPGRPLPPRAQVLVQRTSTSASRSANKDRISRAASAFSAHNADNEKEAWKKHYRAKFPKMVFYFESIPDDVRAKLTKRVTYFGARQEPFFSIDVTHVITTRTIPPERAEGSAQALAASPETDQQRKQQSEEQPQTINPSLLDRNPAARRKLLFEFRQPPSSSQQLKKAGNGNGKPKNNDVLHKAREMGKKIWSLEKFQTMLTVLLESESLNSARNPGARNPLGAFKNPQEPDLLQLLNNERINGPSDRDPTAVSRELVYFKGPYIYVWDMDEKQKPMMVRDYPKVANKADGEWPQFRSVANGRCPFVEDVELMPERKDYRKSREREKARAAAAAAAAATATAKAAPTAAAAAKRHDDVVPMLKPPETVALGTGKRTFAEMEDAGRNALATRTAAPVPLLVSGAAKAQATQNAFISRASACPGRLLGGEPLASGMQPSNVTSAIRSQMISSTSGINGGKAGTSKEVHGLQRKVLQKTTASASHDPSPRRLTEVSADAVSSRSMSRQTSRTVHAQEDEGRPQRAAAAATATPASAKSRSQRTTLRSKKDLKPGYCENCQEKFPDFDDHIISRKHRNFAENNDNWTELDSLLDQLKRIPKYHDGSGSEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7C0</accession>
    <name>A0A367L7C0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-hydroxyisobutyrate dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_4435</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>3-hydroxy-2-methylpropanoate + NAD(+) = 2-methyl-3-oxopropanoate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17681"/>
            <dbReference type="ChEBI" id="CHEBI:11805"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57700"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid degradation; L-valine degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.31" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7C0"/>
    <dbReference type="STRING" id="1330021.A0A367L7C0"/>
    <dbReference type="OrthoDB" id="21615at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008442">
        <property type="term" value="F:3-hydroxyisobutyrate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000006">
        <property type="entry name" value="3-hydroxyisobutyrate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002204">
        <property type="entry name" value="3-OH-isobutyrate_DH-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981:SF7">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22981">
        <property type="entry name" value="3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00895">
        <property type="entry name" value="3_HYDROXYISOBUT_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0101">Branched-chain amino acid catabolism</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="9">
        <location>
            <begin position="27"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="10">
        <location>
            <begin position="198"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI10320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="331" mass="35223" checksum="84615D42B10DF5D3" modified="2018-11-07" version="1">MRATFSRLPFLLPRRGFASTPFRLDNYAFVGLGQMGFQMAKNLRSQLGSNDSVAVFDINQDAMKQLRASVKTGGASLVLASSAFDAAKDADTVITVLPEPQHVRSVYSSILTDSLPARDRVFIDTSTIDPSTSRQVAESVASARQGIFVDAPMSGGVVGATAATLTFMLGCDAAAYVPRIETVLLRMGRKVLHCGRQGTGLSAKLANNYLLALSNIATAEAMNLGIRWGLDPKTLAGVINVSTGRCWPSEVNNPVRGVAESAAASRDYSGGFGVSLMCKDLRLAMVAAEEAGANMVLADTALRVYEATEKQEDCKGRDFSVVYRYIGGGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7K1</accession>
    <name>A0A367L7K1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Bystin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_4396</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bystin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7K1"/>
    <dbReference type="STRING" id="1330021.A0A367L7K1"/>
    <dbReference type="OrthoDB" id="2192561at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007955">
        <property type="entry name" value="Bystin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12821">
        <property type="entry name" value="BYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12821:SF0">
        <property type="entry name" value="BYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05291">
        <property type="entry name" value="Bystin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI10396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="487" mass="54556" checksum="DCE25F4D6128B358" modified="2018-11-07" version="1">MPKAPASMAERQARRHNPLEDDILATGVLRNKPSKKRPRDQNEDEGFVDSRASRDILRIGRELVDEEDAERLSSRPEPVVDNFVYSSRVDEAEAEADAGHAYEDDDDDDAWCDEEEVVEEIEVDPEDLETYTKFMPDRDEDDLLKHGWDRRPSGDEQGESVNLADLILEKIAAFEASEARKEAGLPAEEHQLPPRVVDAYTKIGQILSRYKSGPLPKPFKILPTVPHWEDILEITKPESWTPNACYQATRIFVSHKPAVVQRFLEMVVLEKVRQDIYENKKLNVHLFNSLKKSLYKPAAFFKGFLFPLVGSGTCTLREAHIISAVLARTSIPVLHSAAALKGLCDIAAQEASHGTEGGGATNIFIKTLLEKKYALPYQVIDALVFHFMRFRSVDPAGVREGEPPTEGDARTKLPVIWHQGLLAFAQRYKGDITEDQREALLDLLLSHGHQAIGPEVRRELLAGRGRGVPLEPQNVAFDGDDTMAVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8A8</accession>
    <name>A0A367L8A8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_4321</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8A8"/>
    <dbReference type="STRING" id="1330021.A0A367L8A8"/>
    <dbReference type="OrthoDB" id="5414285at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI10655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="225" mass="24287" checksum="009D8E283A137191" modified="2018-11-07" version="1">MVSVIGGLIIALLVILSLSAVGWFVFAQLRARRLGLPPPGLSSYLPWRHNDDHYGPPRPAPGGVVGWFNDQVRRFKDRNNRSAAGAYEQSLRDGGGGGVRGRRGFGPLDPDEAWDARVGHEADGYGGYYEEQELSAPVRGRSTSDYRGGGYSANLGSAPSAGYDDGQHRGRQPTRSPVGSRNPFDDEAGSSLRGLSPRPMDASTPKKHRSKADSPDRPSVFKENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8X8</accession>
    <name>A0A367L8X8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DUF1264 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_5204</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OBAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8X8"/>
    <dbReference type="STRING" id="1330021.A0A367L8X8"/>
    <dbReference type="OrthoDB" id="1901244at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010686">
        <property type="entry name" value="OBAP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31360:SF0">
        <property type="entry name" value="OIL BODY-ASSOCIATED PROTEIN 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06884">
        <property type="entry name" value="DUF1264"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="362"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="512"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="556"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="581"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="254"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="403"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="269"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="403"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="427"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI10883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="762" mass="85017" checksum="A350D7F9CA17CC83" modified="2018-11-07" version="1">MDGLPVSNKAPGDDVSTENTVLTSAASITQASSDFAPLRNVCAHLNAFHAYADDGSRSVETNHYCGHVNELRRFLNVDDDVRQCLLYDSDESNARLIGIEYMITKRLYEKLPQEERRLWHSHVYEVKSGMLVMPNRNVPARAWDAAETREMRQIVTLYGKAYHLWQTDRGDALPLGEPRLMTSFVADGQLAWGEVERRDGRMGTDYRAKREARRVIDEPEVDAEKPPLESVPASSSMAALPCIIDDCAPSAAREKGAVSTKTAPPSRDTAVEDKEREGKEEEEEEGEEEEEVEEEDKGDGRVQLVRVDKAKKTTNDDGFLYDLLPASRLENNLPWAVGFLELANAGDFAANVWNEVPVPRYAMVLMAFGGTLAFVMSIVAFYDIGRAWRNVLFLLRRRRRRRRRRQPSSRPQLHRHHSSPSPNNHSDDDDDDDDDDDDDDDDDVTGDRKKLRSALRAVSFRELYNEIINRLAMDILMGAGALLIAAGTYMAMGGGNEHVWYASNILSGYLGNTPLALFAVVNSSWALWLAYTAQRHVRATRSSPASALVKRRSRNVQVFCLINGTAAVVGGVGSMLTATRWWAYVLLAPVVVSSIFCNVWWRRRVGYTRSRTRLSSVEEVVSDLEFAAWADVILRQAPSSRPLSRLMADPGSLPEVLRWLRRHHLLSDVCVAAANDPQLRHALVTSSASASTTTTPAELDLGLPELLALPPALHPQLVDVADECVGRLGALHFRHRERFLAELLGSYCCIGGRAPDVEEAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8Z0</accession>
    <name>A0A367L8Z0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_5224</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8Z0"/>
    <dbReference type="STRING" id="1330021.A0A367L8Z0"/>
    <dbReference type="OrthoDB" id="5308502at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018830">
        <property type="entry name" value="DUF2434"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10361">
        <property type="entry name" value="DUF2434"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="527"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI10890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="550" mass="62957" checksum="9333FF0309008807" modified="2018-11-07" version="1">MAVPLDLLRVRELLAFPSGDNDTDTVLAGNHFNLTTLRYWNYTLFSNQTLSNGTKCWLTMQPYQPDYILNNGTFVNATKCWVAIDPIGTRGVVGIILASLYGVALVLSLTALTKHGALFLPKETRFYPIGRRWQWYWAGFVCACALISLLSNIDVDRYYIQELPIVLTCFFWFLICQGTLALTWEAVRHWGSWLERQYVDPNPFVYRQDDRRAMIEFWMPLWFYFWVWMNFFLVIPRGWGFVEKQRSVEQTLAVAIPTATGGRFKGGGFCLFIAWLTIIYSLRHSIHHYKPRNRGMLNRVFGLARFVPWRFALMLPLCLALIAYQVLISFVWDLSLFRFEGMMVPVVFAWGYGPTLLIVCIQIVYGLVTPNEDKELLRQRRERGEDVNRELGIVKRPAWWRRVRGDHITGTLRDKIQKNVAEVGGERGVGRRVEDDVERHARLEALRSAINNDDNDVELGNVTATPSPYTGLPEAERRQANRSTTLLLPEIDVSAAATERAQRLAYLMEDGSPPPYSNGSSRRASEPEPGTEPGTPLESAQPNVRSMLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9L1</accession>
    <name>A0A367L9L1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_5334</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9L1"/>
    <dbReference type="STRING" id="1330021.A0A367L9L1"/>
    <dbReference type="OrthoDB" id="6354873at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006694">
        <property type="entry name" value="Fatty_acid_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050307">
        <property type="entry name" value="Sterol_Desaturase_Related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11863">
        <property type="entry name" value="STEROL DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04116">
        <property type="entry name" value="FA_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid hydroxylase" evidence="6">
        <location>
            <begin position="167"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI10922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="345" mass="40799" checksum="7C49763AD3427A7A" modified="2018-11-07" version="1">MDVVLELTDTFIADFVYAYLFPPRQAPYDFPHPANGSDSAFSAWTYKPASQFIHVQPTQAAYKTSLPRDHPYRQLVTLFFITWIFGILVYFLFATLSYFLIFDKRTLNHPKFIRNQIWLEIVQANKSMPVMAVFTAPLFFLEVRGYGRLYDTTDEGPGLWYNVLQFPLFLLFTDFCIYWIHRYLHHPRIYKHIHKPHHKWIMPTPYASHAFHPLDGFAQSLPYHFFPFIFPLQKMAYVVLFVFVNFWSILIHDGEYLTSNPVVNGAACHSLHHSRFEVNYGQFFTAFDRLGGTYKMPEAWMFEREKRMSEKQWKQESKTVDGFVKEIEGDDERTYGPELAAKKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9R1</accession>
    <name>A0A367L9R1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-rRNA-processing protein PNO1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Pre-rRNA-processing protein pno1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_7365</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for small ribosomal subunit (SSU) synthesis. Has a role in the processing of early nucleolar and late cytoplasmic pre-RNA species.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the small ribosomal subunit, ribosomal RNA processing complex (SSU RRP complex).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PNO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9R1"/>
    <dbReference type="STRING" id="1330021.A0A367L9R1"/>
    <dbReference type="OrthoDB" id="1932641at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22392">
        <property type="entry name" value="KH-I_PNO1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000009">
        <property type="entry name" value="RNA-binding protein PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055211">
        <property type="entry name" value="KH_PNO1_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826">
        <property type="entry name" value="RIBONUCLEASE Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF13">
        <property type="entry name" value="RNA-BINDING PROTEIN PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22891">
        <property type="entry name" value="KH_PNO1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="10">
        <location>
            <begin position="148"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00071744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI11171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="238" mass="26641" checksum="85B002BA90740C14" modified="2018-11-07" version="1">MSAPTALKRATSAPKSPEAQEDNDEFLLDPQNPSPVETQALVVQDREDVVDMMAIDEEGRPRFAPATDTDPVTRTEMRKIPVPPHLEHLKLQCRMNIKRKSVELRTSRHTMDSGALQKGEDFVKAFTLGFDVDDAIALLRLDDLYIETFEIKDVRIMHGDSQARAIGRIAGKDGKTKFAIENVSRTRIVLADSKIHILGGFKNIHIARESIVSLILGKPPGKVYGNLRTVATRMKERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9Y1</accession>
    <name>A0A367L9Y1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Septum-promoting GTP-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_7748</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9Y1"/>
    <dbReference type="STRING" id="1330021.A0A367L9Y1"/>
    <dbReference type="OrthoDB" id="6585768at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090068">
        <property type="term" value="P:positive regulation of cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04128">
        <property type="entry name" value="Spg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000330">
        <property type="entry name" value="Septum-promoting GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017231">
        <property type="entry name" value="Small_GTPase_Tem1/Spg1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI11214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="32700" checksum="BF4B1FE040CDC7BE" modified="2018-11-07" version="1">MDHQPAADHEEQQELPRPASHDGLDDTLGGIEGSPHPVASNNGFHAHQDAPGSPRYDDDNGARQTPPVSAPLSRPGSQMSNPPQHAPGSDYRQSSNEPPNGRNHVVIKVGMVGDAQIGKTSLMVKYVEGSWDEDYIQTLGVNFMEKTISIRNTEITFSIWDLGGQREFVNMLPLVCNDAVAILFMFDLTRKSTLNSIKEWYRQGRGFNKTAIPILVGTKYDHFVNFPPQDQEEISNQARRFAKAMRASLIFSSTSHSINVQKIFKIVLSKAFDLKCTIPEIENVGEPLLLYQNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9Z5</accession>
    <name>A0A367L9Z5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Beta-galactosidase</fullName>
            <ecNumber evidence="5">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_7765</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="5"/>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9Z5"/>
    <dbReference type="STRING" id="1330021.A0A367L9Z5"/>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026283">
        <property type="entry name" value="B-gal_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048912">
        <property type="entry name" value="BetaGal1-like_ABD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048913">
        <property type="entry name" value="BetaGal_gal-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019801">
        <property type="entry name" value="Glyco_hydro_35_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21317">
        <property type="entry name" value="BetaGal_ABD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21467">
        <property type="entry name" value="BetaGal_gal-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006336">
        <property type="entry name" value="B-gal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01182">
        <property type="entry name" value="GLYCOSYL_HYDROL_F35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017082650" description="Beta-galactosidase" evidence="7">
        <location>
            <begin position="22"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase 35 catalytic" evidence="8">
        <location>
            <begin position="29"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase 1-like first all-beta" evidence="9">
        <location>
            <begin position="395"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase galactose-binding" evidence="10">
        <location>
            <begin position="530"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR006336-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI11240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="641" mass="71548" checksum="EB02ACA0400C317F" modified="2018-11-07" version="1">MLFSNSLRALVTACLCLGSSARFTYNETSFLLDGHPFQIIGGQMDPQRIPPPYWVQRLKMARAMGLNTIFSYVFWNEFEPSPGDWDFGDANNVALFIHLAQKEGLKVVLRPGPYVSGERDWGGFPAWLSQVPGLKVRENNDKFLHLSRRYINRLAEEVSHLQASRGGPILMVQLENEYGSFGKDKGYLAEMADILRANFEVFLYTTDIGDRMFLRGGTLPGVLAQTVGDPKTGFPARDEAITDKSMLGPHLASEYHVTWPDDWSSNSAHRKVQRGGMDSIVSDLRWILQAGNSFNIYMFHGGTNWGYDNGAVWASSRTRPVTTSYDYGAPLDESGRPTEMYHRIRRMIAKHLPESSIPPVPQLPEPVQTEEIDLKPSLALFDILPNRLVTDNADPVTMETLGQWQGFVLYQHNVTSGAHGALDVGDKPRDRIIVYQNGQRVGVIDGTYDTPTTVRLTLNEGDLLQLLVENLGRVDFGPGLKDQRKGIVGSVRVGRSMTLKGWSTYSLPLTKVPKALSSKNYADVLENSPPIFYTGYFRVLEHAKPGLGSDTFLTLNGGIKGQIWVNGINLGRYWTIGPQQSLYLPGCYIKPIGSVNDVVVLELEPRIEGPPRAKGIASRLWFNRPDPDRAERLVSAPMFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LA98</accession>
    <name>A0A367LA98_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Transcription factor MST12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L249_7214</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Transcription factor that may function downstream of PMK1 to regulate genes involved in infectious hyphae growth. Is not essential for vegetative growth, conidiation or appressorium formation. May be involved in the regulation of the expression of the cell surface sensor MSB2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the STE12 transcription factor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LA98"/>
    <dbReference type="STRING" id="1330021.A0A367LA98"/>
    <dbReference type="OrthoDB" id="1095242at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990526">
        <property type="term" value="C:Ste12p-Dig1p-Dig2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990527">
        <property type="term" value="C:Tec1p-Ste12p-Dig1p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000243">
        <property type="entry name" value="Probable transcription factor steA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000390">
        <property type="entry name" value="Transcription factor stea"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003120">
        <property type="entry name" value="Ste12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052127">
        <property type="entry name" value="STE12_transcription_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47427">
        <property type="entry name" value="PROTEIN STE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47427:SF1">
        <property type="entry name" value="PROTEIN STE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02200">
        <property type="entry name" value="STE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00424">
        <property type="entry name" value="STE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="559"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="14">
        <location>
            <begin position="589"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="198"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="393"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="602"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="203"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="469"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="654"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00054208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00074197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCI11358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="696" mass="75935" checksum="BC69846E3AACB724" modified="2018-11-07" version="1">MYSQHGAMAPQKPETFMLSTEAQQALPHDAQVALQQVDNLKYFLISAPVDWQPDQYIRRFLLPTGEYVSCDNLFHISGTDIVRCLSFRFQAFGRPVKNSKKFEEGIFSDLRNLKSGTDASLEEPKSAFLDFLYKNNCIRTQKKQKVFYWYSVPHDRLFLDALERDLKREKMGQEATTVAVSEPALSFQYDSSQSLYEQLTKTQQANSSSFSAQQPAFPPGQPSSPVMRNMDAMPPPHMMPQPMAPLPEGMDPMVPYDSMPMPSAVTQQVKRDPDFARVQYNQNGVPMTQGHQRHASMPPYGLEYSPAPSFVSSQYEDYSNRGISFEPITPPQQALGMAGEPAYIANEETGLYSAIPDHVPGINGVGQLPPSSMPGSQFPRSYGANNVYSVIEGSPTYKQRRRRSSIPPSVSGMAAPPVGNPTASASAAHRPSDLRRSVSASVGPVPEGDELTDNSPPGLAYSASVTSQPHKDVVDMSRHGTPLSTVDGSPALNPMALHQDFSQLPSSDDYSAAAAAAAAAADASLKGHRRNVSGGPNGVVRRARSATVMELGPYPHKSHSCPIPTCGRLFKRLEHLKRHVRTHTQEKPYICPHCSKAFSRSDNLAQHKRTHSREDGGESSMNMSAEEEEELSGEDHLGSLEEASPTSEVAYVSGSMNAGPSDAGSSNMNDSQGFNSLQTLSMPMTISQPATIDGVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAA1</accession>
    <name>A0A367LAA1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7604</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAA1"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="59" mass="6727" checksum="97474D64D0E1E235" modified="2018-11-07" version="1">MSQINSNRTRTDQPPPSKSIVMQNINVPVERWFLLPPCPASTTTIVYTHQTIPHIQGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAF2</accession>
    <name>A0A367LAF2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_7688</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAF2"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI11399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="177" mass="21286" checksum="476B3261C176A7CA" modified="2018-11-07" version="1">MLPNKLVGSHDRHRYNFTSDTSTTQLLPQHHPYATYTSYPLIFFLIFNYLYIFTYLLPFLLLFPDQAAWARKRKKKKGKKRKQRERADWPETNKDRKKEKENSYPYYSHYDFSNYVSRHKLQRSQLGWSSPNPSPSILSYRTAGRPTTCSDFRRAVHHGHLEGSLQRESERRRREAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAM4</accession>
    <name>A0A367LAM4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWR1-complex protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_7195</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SWC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAM4"/>
    <dbReference type="STRING" id="1330021.A0A367LAM4"/>
    <dbReference type="OrthoDB" id="445677at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011421">
        <property type="entry name" value="BCNT-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027124">
        <property type="entry name" value="Swc5/CFDP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48407">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48407:SF1">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07572">
        <property type="entry name" value="BCNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51279">
        <property type="entry name" value="BCNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BCNT-C" evidence="4">
        <location>
            <begin position="243"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="308"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="488"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="98"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="348"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="525"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI11469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="548" mass="61429" checksum="09A1D61CE5DD9B19" modified="2018-11-07" version="1">MTNDDDDEQYISSQDSDFAPDEAPAHEGSDASDSEDEPRRQDGPTKRRRSEAEDEEDGYNNSGDEAVIQKGRKRQKRNKGEEHLYDGGEGGLIKTRRQRAEEKAERHHNATIGPVTVDVDALWEQMTSGKPIPPKDEQPAKDDDRPDESADGCTKLESRDPSNQPDTMVIKRIYNFAGRIHTEEKVVARDSAEGRLHLSTLSTKEAAAAEEEGANARPQTRKAFRSAFEPIVDNALSSSPRTDLDLGLAARRRAAQEAQAKKLNTVEKSRMDWAGYVDREGIQDELALASKSKDSYNAQEVFRRHFEARFQPLPPPTAASPAPNTDEEDADGQDEWMGFSDDDDPSEDERNAIEVVDHTSAPPAPANSKPKRHERKPPRPPGPNTPEDAPSLLAQDVALQRLLSESNLEQETRTKRQTKLFSSGKARVQATKMRILRGTTVADNMAMTRTTTEQKRMPMKMRKGIKAAQKAREEKRITQARENGILVEKTNNKSPPSSRMAMMKKRRRMSSSSTRRDPNAVGTFRRGELRLSQRDVDSIQHSRDVFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAQ9</accession>
    <name>A0A367LAQ9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Conserved oligomeric Golgi complex subunit 6</fullName>
            <shortName evidence="10">COG complex subunit 6</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 10">Component of oligomeric Golgi complex 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_7411</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as a component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the conserved oligomeric Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the COG6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAQ9"/>
    <dbReference type="STRING" id="1330021.A0A367LAQ9"/>
    <dbReference type="OrthoDB" id="272987at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010490">
        <property type="entry name" value="COG6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048369">
        <property type="entry name" value="COG6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048368">
        <property type="entry name" value="COG6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506">
        <property type="entry name" value="COMPONENT OF OLIGOMERIC GOLGI COMPLEX 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20653">
        <property type="entry name" value="COG6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06419">
        <property type="entry name" value="COG6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01087">
        <property type="entry name" value="COG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric complex COG6 N-terminal" evidence="12">
        <location>
            <begin position="62"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved Oligomeric Golgi complex subunit 6 C-terminal" evidence="13">
        <location>
            <begin position="207"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF06419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI11332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="680" mass="76980" checksum="8B64CEB19C41F1BA" modified="2018-11-07" version="1">MPPAECTRGASTGVGSKKLPNLQHQPGVAVFEVHTPQSATVSAILSTTYSDTGFREALSFLDDRPTGVHPRRRRRIRLDILKDVINTDGAILDNFMRVAKQLSHIQIVLTRLSKGYEEMRSRIERSHCKISPALTDAASLFQQQNLVEAKQRTLVLFRNSFIMPDDEIDHLRVNSVPIDERFFMALSRASRICEECHALLGFENQIIGTELMEQTSRDITAAYHKLYTYVHRELRTLNLESPVMNSFIRQALRTLAERPSLFRQSLEFFVEARERVLTDAFQIALAGGGTSREVNRAFKPIDLVAHDPIRYAGDMFAWVHSTAVTELEAVDALFVSRGDEPGGEIESDSGVEPRQFSINAEVGDFLKKWAIGDLVDRDMAGVSRILRQRVEQVIHSNEEAITACKLVVLITFYGVTLQKLVGEKSNLLDGIDNLKRQASRQFRALVKDNVSIHLTELQHVPPDLGPPVGLHDTLSQLETLMEIYQSSYSARDAENDCTFILSEAFHPCMSACISISTALNHPANSIFIINCNYVAEKVLQSFVFTRREAATLRDEISREADKLITYQTNVFRQSSGLDRLIVRQDVSKDFLKQEVLQQVSQRLDNFLPSALVDAMERLDHILDKKLSRQITEAASQQFFREFELLEANIEQIDEQITEPTETRLRSYFPRTAAEIRVLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2024-01-24" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCZ4</accession>
    <name>A0A367LCZ4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCZ4"/>
    <dbReference type="STRING" id="1330021.A0A367LCZ4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="411" mass="46027" checksum="228E7C0C5669A11F" modified="2018-11-07" version="1">MGEIVGKLRPHPSGPGISYTAHDRKSSSAPIGTGIRPVPRFEPLAAGVVNKVFPKFATHSDGSCPVEVPEAFKGKVSSVRPQRVSGKCSFYLGQGCTDISVEGFYPGRRLYGHFDNKIHSVRCNSEVGVHESRYDSWTWSNQTRQDLCKHVYELWFYIKLSPGLRSVALHFNGFFEHWQVPWLMNVTSPTTPEGSDWYRVDMKDIFTHSPIPLQHLVGKMSLTARAIRGGELKIVDAKLVARCTDSDIALWMNSFSIHAQTITTESPPTAEWTYDVTANDWAPVGPCSYFQKLKVSVNFISRTKNKIYATMAGERLLVVDQPRARASYTTEVQLYRVYKSRIVTPATVSRISLSNEGGDTGVAIESVTLDAVCSGSSTGYQLVIKRDDDVWLMAGKTWDLDIKHWKWKNEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LD61</accession>
    <name>A0A367LD61_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0211</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LD61"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="134" mass="15203" checksum="AAD2FD90CB645C70" modified="2018-11-07" version="1" fragment="single">MIVVWLAMRLRKTCNGRGLFFFFFIVFFSTIIQPRSCTQVVYIPIPSFPEPAPRRHGSVKSKAQHIQTLFAAGLVDDFRPSRQLPHPEARPRLVQKPRDRGSRHGARTFRAPVLNAIAARPGRSLKSLDPENGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDL0</accession>
    <name>A0A367LDL0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Endoplasmic reticulum transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L249_1303</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the BCAP29/BCAP31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDL0"/>
    <dbReference type="STRING" id="1330021.A0A367LDL0"/>
    <dbReference type="OrthoDB" id="435607at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070973">
        <property type="term" value="P:protein localization to endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008417">
        <property type="entry name" value="BAP29/BAP31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040463">
        <property type="entry name" value="BAP29/BAP31_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041672">
        <property type="entry name" value="Bap31/Bap29_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701">
        <property type="entry name" value="BCR-ASSOCIATED PROTEIN, BAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12701:SF20">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05529">
        <property type="entry name" value="Bap31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18035">
        <property type="entry name" value="Bap31_Bap29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 11" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="BAP29/BAP31 transmembrane" evidence="13">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Bap31/Bap29 cytoplasmic coiled-coil" evidence="14">
        <location>
            <begin position="163"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="132"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF18035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCI12518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="212" mass="24690" checksum="71FDFBF13CC4E9CF" modified="2018-11-07" version="1">MTLYYTLVFVLLMFEMGLFMLLLVPLPFSMKRRIFTFISENPLVAKVEYWMKITFVFILILFIDSVNRVYRVQQELMAASEQSSKGSTTIIGSERLEVQARKFYSQRNMYLCGFTLFLSLILNRTYVMIVEVMRLEDRLKTYEGTNKDAKESEKLAVAGKPGELAALKEKLARKEEDLQTLKKQSAQLHKSYDELSDKYGALQKETEARKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDQ9</accession>
    <name>A0A367LDQ9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDQ9"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="77" mass="9003" checksum="D3A295A9024204AA" modified="2018-11-07" version="1">MWMDGVGGETNSRNARSPHLAEEEEEEEEEEGLCLHPGRRDGWMDRWGWLGTWYVVGRRTDFFGIEFARENSDVILT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LE16</accession>
    <name>A0A367LE16_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_0875</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LE16"/>
    <dbReference type="STRING" id="1330021.A0A367LE16"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI12668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="122" mass="13682" checksum="F0A25BD2331D31F6" modified="2018-11-07" version="1">MQYERLLFDFYVETGDKDPILNPRESSSELSDPFVSSPTDLFAELLSELSDFSINTPSDLLFNNSKGNKAAKKIAAKEQKTTTKKISRYNRPFKNPTLFCAEGRTLSKKAKTLVVTLKAIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LE78</accession>
    <name>A0A367LE78_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cupin 2 conserved barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1066</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LE78"/>
    <dbReference type="STRING" id="1330021.A0A367LE78"/>
    <dbReference type="OrthoDB" id="9976870at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="23440" checksum="E7DFECB342CF9E11" modified="2018-11-07" version="1">MVWAWQLWLSPRPLRRTIITSNNSFLAAHDAALFEFLQDENDRWVVQETHYIKNRIVKNGLSGPPLHIHWLQKEFFKVKKGVIGIHRNGQEIAATSSDGIIEIPAGTRHRFWAHASSQEDLIFQVWAEPQDLTYSFDENFLRNFVGYHRDCQKANIKPSVFQIILLSYNSATVATPPFWMPLWILKLVHYLLAYWIGAALLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEC3</accession>
    <name>A0A367LEC3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_0955</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEC3"/>
    <dbReference type="STRING" id="1330021.A0A367LEC3"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF63">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI12775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="285" mass="30317" checksum="4C7F8644312E5FA8" modified="2018-11-07" version="1">MASTASSGRLAGKNAVITGAAGGIGLETSVLFAKEGANVLLADISRPALEKALAKVKQLVPSAARVEVKECDVAKEAQVQALVEALDPWGGLDIMFNNAGIMHAQDDDAVNTPEYIWDLTQNINVKGVWFGCKHAVLALRRHGKTRGSIINTASFVALMGAATPQLAYTASKGAVLALTRELAMVHAREGFRFNSLCPAPLNTPLLQDWLGDDKEKRHRREVHFPSGRFGEAIEQAHAVVFLASDEASFVNGHDFVVDGGLSKAYVTPNGPPTAAPRNNALKDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEJ5</accession>
    <name>A0A367LEJ5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">4Fe-4S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L249_0627</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I 23 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEJ5"/>
    <dbReference type="STRING" id="1330021.A0A367LEJ5"/>
    <dbReference type="OrthoDB" id="4337792at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3270:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit I 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01351">
        <property type="entry name" value="NDH1_NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010226">
        <property type="entry name" value="NADH_quinone_OxRdtase_chainI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01971">
        <property type="entry name" value="NuoI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004538">
        <property type="entry name" value="PRK05888.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004539">
        <property type="entry name" value="PRK05888.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF131">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="14">
        <location>
            <begin position="823"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="14">
        <location>
            <begin position="862"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="57"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="744"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="753"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCI12841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="931" mass="103115" checksum="EDC3AAAA7673F5F6" modified="2018-11-07" version="1">MNNKRCDRQTPCQPCAKDEPGPCVYVYDSRPSHTKAPFQGHQTKFSVFKYTPVAKAPPVEKEAQSQASSFSTEMNDETGSAGTETEAESSGTEGTLSLDTFAPSSFPLPDPSLCLYPAPMAPFQNDGCAVSSPPSPLPEVRFYGNSHWTNYFHPDADDIISVLQTHESEAPAQGSATLASCEALARTIRYHEEVTAQMTDTSGGLVPTRDVSDRLVEAFLRTYQTVLGILHVPSFREEYRTFWEAPTSSTPAFTMTLFLVMSIGSVFCPHETTIPRAVVLKWLSVSSTVISSHPTTANVDSLRIRCLLLLAQSVSSTAEGRAQWISTGSLVRTAMSQGLHRDPASTRHQVHEMSASEMESRRKLWAAILELDLQSSMDCGGLPSVDSQDYDTALPSNADDDDFPRATMDGAFVESKPFEEFTSSSFQVLLMKLLPVRLKIARLVNGPRCEASFAHVLNLGHELGQLLQLCSARIETYCFSGRRPAAFTMKTFELLVKRFLVALHHPFTRMEETCPFAFCSLSTCLESSISILSTLSGGTDGDDFQMAQMRGSGMFHRVYIQTALYICGELRKRAGLAGSDSFELSNLIIQYLDSAPQRMDYGDFKVRAYMLVSASLAYVEAARSGVPPEMHVSQAVRKSLDISYARLAIRLPPGPGIEDVSQQSTSVVWSPWSSLDDEREGWLILATAQLSSLIRHFRFHGAVSPTKMASTVILSRRQLISTTRAATFSAAARTAVTARNDARRGYATPRGQPPSNFRTIKASQRPGDDDSTLDRLGKYFLLTEMARGMYVLLEQFFRPPYTIYYPFEKGPISPRFRGEHALRRYPTGEERCIACKLCEAICPAQAITIEAEERADGSRRTTRYDIDMTKCIYCGFCQESCPVDAIVESPNAEYATETREELLYNKEKLLANGDKWEPELAAAIRADAPYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEW5</accession>
    <name>A0A367LEW5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_0950</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>oxaloacetate + acetyl-CoA + H2O = citrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16845"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>propanoyl-CoA + oxaloacetate + H2O = (2S,3S)-2-methylcitrate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23780"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57392"/>
            <dbReference type="ChEBI" id="CHEBI:58853"/>
            <dbReference type="EC" id="2.3.3.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Organic acid metabolism; propanoate degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the citrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEW5"/>
    <dbReference type="STRING" id="1330021.A0A367LEW5"/>
    <dbReference type="OrthoDB" id="8017587at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050440">
        <property type="term" value="F:2-methylcitrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036440">
        <property type="term" value="F:citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.580.10:FF:000001">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019810">
        <property type="entry name" value="Citrate_synthase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007128">
        <property type="entry name" value="PRK09569.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739:SF15">
        <property type="entry name" value="CITRATE SYNTHASE 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00480">
        <property type="entry name" value="CITRATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="25"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI12772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="509" mass="55836" checksum="62DD1B7E221D083C" modified="2018-11-07" version="1">MTAFMRLLPRQAACRRARVPSAMSFTRSYSSESGSTTSDAGSTSSEAETSNSSESDASETKEPNLKATLRSLIPAKRELLAEFKKSYGDKVIADVRVDNVLGGMRGLRSLLWEGSVLDPQEGIRFHGRTIKDCQRDLPRGTTGTQMLPEAMFWLLLTGQVPTENQVRVLSRQLAAQMGLPGHVRGILAILPRDMHPMTKFAMGVAALNLKSKFAQAYEAGIPKKDYWETTFDDSIALLAKLPTIAATIYKNTVEPRSGGHHEIAKKAGKDKDWAQNFVSMLDIKDSKRESFEDMMRLYLALHGDHEGGNVSAHATHLVGSALSDPFLSYSAGLLGLAGPLHGLAAQEAVRYVKMMKQGIPAEYSDEDVTQYVWKTLRQDRVVPGYGHAVLRKPDPRFEALMEFGASQPAISDSAFFRLVQSMSRVVPQVLQEHGKTKNPFPNVDSISGVLFNQYGIQKHPFYTVAFGVSRGIGPLAQLIWDRALGLPIERPKSVSLAGLAQLVESSESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LF46</accession>
    <name>A0A367LF46_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0074</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LF46"/>
    <dbReference type="OrthoDB" id="4924678at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="127" mass="13462" checksum="811D3BE8D5E355B7" modified="2018-11-07" version="1">MTKGSQWSLEVKVGAASSRSSARSNHPTSSNSSSSSSNSSSNSSSNSSPSPHRNETMNRAVADQVSRWLNDGNAPGAVPPDAQGRPQCRACHAQSVIAPFAIKGQPLPRCLLGPNERGPCRLHVQWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LF82</accession>
    <name>A0A367LF82_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LF82"/>
    <dbReference type="OrthoDB" id="2448307at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040410">
        <property type="entry name" value="UPF0658_Golgi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34391:SF1">
        <property type="entry name" value="UPF0658 GOLGI APPARATUS MEMBRANE PROTEIN C1952.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="353" mass="40164" checksum="7DC1623B3DE1438B" modified="2018-11-07" version="1">MPPRSVYRDRMSFLKSKWPAAFMAVASLQAVVCLAFESFVFACFQSSLGRWVNNPNVQSQYKTIPTFLTLIIFGFLYELVVVWDALRMKNTIQVIGVCIANLALLVYTAIQVDQIQMAIKNLGAEALKPGITSEQVWANVRPFLVAIPAIIALATSAMVFIAWKLYQEFAWDILKNIGADYRMKKRFLHYQIYIALLKFDFFFFLGFIIQFVVIVAQKTDPEFALTIATIPITICILLAAAYFTRRENKPGMMAVIILYLGGLTYFIFKLVRIYQPTYTLFYLPVRKSLTAFAVITILLILLTIANAIICMRNFDNGLKAHLLSPRRVDEKPDAHSISLHDVKPQIPSRMTID</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFB4</accession>
    <name>A0A367LFB4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_0052</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFB4"/>
    <dbReference type="STRING" id="1330021.A0A367LFB4"/>
    <dbReference type="OrthoDB" id="4582561at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="366"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="493"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="529"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="578"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI13118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="601" mass="66641" checksum="582C5C6D73D43354" modified="2018-11-07" version="1">MKETVSLVDAAASASTSAPTSTSTTSASAVNHPIPLSIQLVPQNNVEGVTGFFPFNDLDDIASIQNRGLFQRLPITPAINGNLHISLFPAGCRIQANNGGQVETDCHRACQDPATIFGSLETFYNCAALSAVVYWTSSVNVFYVPEEAERNASLLMAGVPLADFDAKPTLSCFVSCAEAACENDNLRMPCSHSVMTLTPKSEPLVVLEAMSSFCPQLPVDINPDIFGPGVLISYVLQVCFASLLFVFVKIFVIWVHHVQQSKTKTKQGPVSRMNLPRRLTWHDSSALSRTSIALATTLVEFQEAQCWFVFAIQIASILTVVVSSQGGTFWAEIIVNASVAFHVSQNGILSMFLIQICLHSEGIRNWHTFVGFFAEYLLAIVATSQTIYFQDAFELFRKQKQLRACGGNPSPRSYCSSMRVVDGFHLSFFPRPYVYKIVFLVLDTVTILILLADQLSWTLRTNRRTKNLRVCGHPVGHGPVGRYKPMWDWFKKWLWRLLELAYFVINILYMISLVKVFNHNSFDASKWSYGQIIAMTVWGPVIVKLFDLVISGPPKNGSTLTSGPPRLRIDNVINQRLGKNPQDDAYSTRPKCTGPSQSTEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFC8</accession>
    <name>A0A367LFC8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Meiotically up-regulated protein Msb1/Mug8 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_1280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFC8"/>
    <dbReference type="STRING" id="1330021.A0A367LFC8"/>
    <dbReference type="OrthoDB" id="3362494at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037508">
        <property type="entry name" value="Msb1/Mug8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012965">
        <property type="entry name" value="Msb1/Mug8_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28093">
        <property type="entry name" value="MORPHOGENESIS-RELATED PROTEIN MSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28093:SF1">
        <property type="entry name" value="MORPHOGENESIS-RELATED PROTEIN MSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08101">
        <property type="entry name" value="Msb1-Mug8_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Meiotically up-regulated protein Msb1/Mug8" evidence="2">
        <location>
            <begin position="44"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Meiotically up-regulated protein Msb1/Mug8" evidence="2">
        <location>
            <begin position="184"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="695"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1060"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="471"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="703"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="749"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="807"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="847"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="883"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="897"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="953"/>
            <end position="962"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI13126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1080" mass="118123" checksum="DD9B31E829D5C9C7" modified="2018-11-07" version="1">MPGLFSRLKGRDGVKSKKKVAAGDSTASQPQRQRWDDAYARMTVEPEEVHDLLHYCTAELKARGLDIPFLLLPFRPTSNPSAVRTFIRHFFDQSYSLRGQVLLQELRMTEPMVGTHLWPFRLRLIARTLTQFDTGHFWSCEMVLEPSAGWHHRLGRLRALQGWRIRYVAVAASLPALRSPPAPDSNKARDSFKTFIPISVENGAKQRIIFDFFDLIAAIAAHGKSNGFGGRKLSRMAAWWAFDHRDTGTGFDGGYNAWLSAADATSHLFFAYLRSLSPEQNLTGISMLPRSLEKLLKETEYPPPTPRQLMSSTNKLAMVVDVVSPTPFALLRRAGHFEYRDSDVGLQEFSDYEDPVKALTEECFRVLKAISAANQSQVSSAKHSTSLRDASWSRFEDIGFASPLDEDDADDDGTAATRLQGIRSTPVSGAYQGRPTTPSWADFLSSGFNDENSARANMLLPPDKAIPPLESQMRQQQSSQSHRPRLEQEGNLEPGELASINVIDLDDAFWWVWMSSLSPEETPERKSAFGRCAVIETRISSARWIVVEELIVGAAPEPQAGAYIAEKKRFFSWTKRGRTLSRHKSTMKKNQDRSDANAAKTGPIKPVGAETQARIQAKAAQLRAVKDHEQRAAEEAASLHRRGRTDAELMAERTNSVFTLQPNIVGEASSAMKWVNKYDKGAVKDAYLANTSAGRGLAVSPAPSDQANTRPSSTNGGETGADHQAPVAESQQPAGSVHSHAPDPEETRVSSSTKAPASTVTPSLRDSVEHASGAAAQTNVVEPKKSSSERHKLHRNATVGGKEKSGGFRKLKLFSRKNRSSKVPQNAAANLDGMIQQQRPVAAPEVPQTPTPAATPPPTKETIAPAPPPKPVTPTEPPSLPDRAPETPKSLDHPAEEPEALPEAEIEPEPESEPGELVSTEVLSHIDTRDAAEANQEFSRFDQGPLTDQPAFDPEEEEEAAEAQDATPPPIARYPRATTPKAPELERAALDKLNQGASPGVQDRWAQIRKNAAQRAATRKDEPSRVVVRKSIDGDEDTSGEESAYSIESRVARIKARVAELTGGAANGNGNGAQPAVKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFV9</accession>
    <name>A0A367LFV9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cleavage and polyadenylation specificity factor subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Cleavage and polyadenylation specificity factor 100 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_0116</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFV9"/>
    <dbReference type="STRING" id="1330021.A0A367LFV9"/>
    <dbReference type="OrthoDB" id="64353at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16293">
        <property type="entry name" value="CPSF2-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027075">
        <property type="entry name" value="CPSF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025069">
        <property type="entry name" value="Cpsf2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035639">
        <property type="entry name" value="CPSF2_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922:SF1">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13299">
        <property type="entry name" value="CPSF100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Beta-Casp" evidence="6">
        <location>
            <begin position="286"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="502"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="609"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="843"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="514"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="541"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="609"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="633"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="662"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="680"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="854"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="883"/>
            <end position="899"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI13277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1015" mass="109168" checksum="4BF04701F5C7B76E" modified="2018-11-07" version="1">MFTFCPLQGALSESNASQHLLELDGGVKVLIDLGWDDFFDVAKLEELEKHVPTLSLILLTHATVSHLAAYVHCCKNIPLFTRVPAYATRPVIDLGRSLSQDLYSSTPAASTTISQSSLSDLVYSFSQTAPTAAAQNFLLESPTPNEIARYFSLIQPLKYSQPHQPLPSPFSPPLNGLTITAYNAGHTLGGTIWHIQHGLESIVYALDWNQARENVFAGAAWLDGAGGGGAQVIEQLRKPTALICSSRGSAQAGGRLKRDETLIDMIRACVANKGTVLIPVDSSARVLEMAYLLEHAWRADEDGSLKSARLYLAGRNMSSTMRYARSMLEWMDNNIVQEFEACAEGQRKANGAGPDKKDAGPFDFKHLRLLERKAQVAKLLSRGDKQGRVILASDTSMEWGFSKTLIKGLAGDSNNLVILTDTPSLAKDGSPSVARKLWEWWRERRDGIFVINTPGGDSLETVYGGGRDLEIREATRESLQGDELAMYQQWLATQRQLQATQHAGGVTSALEASADADDASSESSSDSDDDDDDGGGGGQQQGKALTVSATMGQAGRKNVVLKDEDLGITILVKRKGVYDFVSHGKKGRDRCFPMPIRRKRNDDFGELVRPEDYLRAEEKDDENADGGNEATEDDKPGKKRKWDDVVSGRPRRRTVGSKGQPAAATTTMTTTTTTTTATTDEADGPEPDDLDALDEPEPEEPKGPSKVVYSSEVVVANLRIGFVEFSGLHDRRSLDMLIPLIQPRKLILVGGNREETMALAADCRMALGLEGGDRAVDVFTPEVGSWVDASVDTNAWVVRLADALVKKLKWQTVRGFSIVTISGQLLAGGGNAAEAADEGRAKKANKALGGRSNEDDDDEAVDDDRDEDGAPSAKRLKTDPGGSTTTTTTTTTTTTTMTTTMTSTALTAPAPAPPLLPVLEAVPPNRLSATRTAAQPLHVGDLRLADLRRAMQGAGHGAEFRGEGMLVVDGTVAVRKTAEGRVEVESVALPAVGRRSAVYAVKKAIYDGLAVVAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGY8</accession>
    <name>A0A367LGY8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">asparagine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L249_7973</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12 13">Belongs to the arginase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGY8"/>
    <dbReference type="STRING" id="1330021.A0A367LGY8"/>
    <dbReference type="OrthoDB" id="1931232at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016813">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11592">
        <property type="entry name" value="Agmatinase_PAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04323">
        <property type="entry name" value="AsnRS_cyto_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.10:FF:000014">
        <property type="entry name" value="Arginase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1910.20">
        <property type="entry name" value="asparaginyl-tRNA synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.10">
        <property type="entry name" value="Ureohydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048952">
        <property type="entry name" value="AsnRS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006035">
        <property type="entry name" value="Ureohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020855">
        <property type="entry name" value="Ureohydrolase_Mn_BS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF16">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00491">
        <property type="entry name" value="Arginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20917">
        <property type="entry name" value="AsnRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00116">
        <property type="entry name" value="ARGINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01053">
        <property type="entry name" value="ARGINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51409">
        <property type="entry name" value="ARGINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016720105" description="asparagine--tRNA ligase" evidence="14">
        <location>
            <begin position="21"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="15">
        <location>
            <begin position="671"/>
            <end position="968"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCI13685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="976" mass="106907" checksum="922DD8C411C1A5E4" modified="2018-11-07" version="1">MKSAAALAGLVAASACAAHGTHDDDAGAWSKEALAELGAKWGYEWGFSGIGSFAHLDHVKCLTDPSVDFDIAIIGAPFDTAVTFRPGARFGPRAIRQASARQTAFRGFNPRAGFNPYQNWAKIIDCGDIPITPFDNQIALEQMTQAFLELGKRKPPPGSRATNPKPRLVTLGGDHSLALPALRAIKEIYGRPVRVLHFDAHLDTWDPHSYPAAWGATQFTHGSMFWMANNEGLLTNSSSSPSVHAGLRTRLSGDSWADNDSDGAQGWVRFSADDMDDKGTAGIIEGIMKTLGTEDPVYLSVDIDVLDPAFAPGTGTPEPGGWTTRELIRVLRGIEGLNLVGADVVEVSPAYQGRGEETALAAAQVVYEMVTSMVKRGGIKDKAHAKDELQTPPVQELAERTRPSGESVYVDADTGVDDASADGSEAKPFKSLSFAFIQNIGRPDANYLTRASVTGPDEDASARLAWKAPAKSAVKKAQGAVDAHKKKLAKQQQVQASEDAKKQQRLGNLEASKKIVIKEDPSLPKAVKMTIGDKSVALGDGGGVKGTRVKVSGRIHRLRAQKQATFITLVDGRGHLQCVLQAGDLTKTYDALLFAQGTSLTLYGEMRKVPDGQTAPDGRELHVDYYTVIGTSPGDEEAMTNKVSSAQNQWDQLMLDNRHLVLRGDNASAVMKLRASVEWAFMTAYHDMGFVKVSPPALVQTQVEGGATLFTVPYYDEVAYLTQSSQLYLETALPSLGNVYCIEKSFRAEKSLTRRHLSEYTHVEAELDFIEFTDMLDHIEEVICRVVDSVLDNAEMARLLKELNPSFVRPSRPFLRMKYVDAIDWLNKQDPPILNEEGNAHAFGDDIAEAAERRMTDIINRPIFLTHFPVEIKAFYMKKDPSDLRVTESVDCLMPGVGEIVGGSMRMEGYDELLAAYEKQGISAKDYYWYTDQRKYGTSPHGGYGLGLERFLAWMANQHTVRTTCLYPRFMGRCKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHX7</accession>
    <name>A0A367LHX7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome P450 monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_8195</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI14021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHX7"/>
    <dbReference type="STRING" id="1330021.A0A367LHX7"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI14021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="515" mass="58419" checksum="D1B397082C381A38" modified="2018-11-07" version="1">MVNLSDAAWHSAVETRGPLHAPAGSRWSYYAVIGAILLVAWWTQSWKRPCVITVPLYKASKTRWIFSAEALIKDSYRKFQDKVYQIRGTEGTQLVLPSNYVGELKALPEDILSAKEAISDALQSKYTKFSPGHNADLLTLLLRTRLTHNLDKLAPQLKEELDYVIATEFPACDEWTAVKWHPFALRAVTRLSGRAFVGPDINRQERWMDTSINFAVHVFMAGAKLQIFPEWARPLTQYLVSDLGKIRRDIEMAKELIQPVLEQRLRHLDEPAGWGEAPNDMMQWLIEALPEEEKADLQTQAELQLVIAAASIHTTTGLLCECLYDLAAHPAVQDELRDEARQVLEADDGWTRKESMAKLKKMDSFMREVQRLRGNIVSFLRKVMKPISLSDGTRLPVGTRVVAPLAGIAHDERFFPNADHFDPLRFYRLRQESAKANSRLQFTAIGDTYVNFGAGRHACPGRFFAGNVIKLALARFILAYDIRLRSGDERPKPLSIVMTKSPSPDAVLEFRRRDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LID3</accession>
    <name>A0A367LID3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5961</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LID3"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="118" mass="13729" checksum="C0461679D50ECC05" modified="2018-11-07" version="1">MKLKLIMNWKYYKVLYYSTITWLYVTPFHFNVMDQPDDLTLVRPSRSGAMTAISTARRSLYSAPIAVQRADRCNDRCNESIGRYNRYSPTVTQGVVAGLRPNWYNLFQVALQAYFLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIJ2</accession>
    <name>A0A367LIJ2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIJ2"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="171" mass="18906" checksum="3D486F5CA70C7E6D" modified="2018-11-07" version="1" fragment="single">AIAQSSRLKRKPLLPRSPFNSNKTLFLEGHVTPGRLQPARGRRTLQRLYVTAAERHNNVGGGYGYAVQRLRPYGPYGPYEGRNLIANSTLFFFDLCGRYSYGYGYGRRPRTRPEGLGGSRNAGPAAAGPRPPYVTEAVRHSGCGYGYAVQRLRPYGPYGPYEGRNVGPLAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIM1</accession>
    <name>A0A367LIM1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Biogenesis of lysosome-related organelles complex 1 subunit KXD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">KxDL homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_6139</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in endosomal cargo sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the KXD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIM1"/>
    <dbReference type="OrthoDB" id="4089816at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031083">
        <property type="term" value="C:BLOC-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032880">
        <property type="term" value="P:regulation of protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051390">
        <property type="entry name" value="BLOC-1_subunit_KXD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019371">
        <property type="entry name" value="KxDL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37787">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT KXD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37787:SF1">
        <property type="entry name" value="BIOGENESIS OF LYSOSOME-RELATED ORGANELLES COMPLEX 1 SUBUNIT KXD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10241">
        <property type="entry name" value="KxDL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="KxDL" evidence="9">
        <location>
            <begin position="87"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI14278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="184" mass="20321" checksum="60FFB017217B4003" modified="2018-11-07" version="1">MSGHYSTTSYSMPMAVPSKGNQYPTYSQYSMSPPECDDSYSSASGVGSYGNSGFSATSSGYMGCSVGDYDSTGSASGVDFQEYMQERFANSFNPIPLDRSMAVQAQTSGKLNAKHRELLDLQKQAQARLARTRERFNEGVRDAREVRGDLEWTQKKVSSLQTKAARKHPKEYAKARARYPSPEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJ42</accession>
    <name>A0A367LJ42_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">chitinase</fullName>
            <ecNumber evidence="4">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">L249_6131</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the secreted LysM effector family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="4"/>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LJ42"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00035">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02878">
        <property type="entry name" value="GH18_zymocin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053214">
        <property type="entry name" value="LysM12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700:SF2">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700">
        <property type="entry name" value="V CHITINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13720)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="6" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="11 14" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0843">Virulence</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1253"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1282"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1309"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="16">
        <location>
            <begin position="332"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="16">
        <location>
            <begin position="396"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="17">
        <location>
            <begin position="540"/>
            <end position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RCI14282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1370" mass="148513" checksum="4657938CD5026065" modified="2018-11-07" version="1">MWKHGLFKHPRRPCPTQLLFSTRASRLKTLVVQRAPFLLILVIRCACLSRCLAKFTLLSLTPTMSSLAVLVIVCAALLAGVEAEPGDNALSSELQACPASCRGSPQLWTVYGSLERLESCSGPMLLDFSIHNALDNPEAVVKIRACEANAFLEQEARSPGTCFRGSGTKAVFELATGGDKTSADTKPVLRALGDHLGDRAHCDERLFFGLGRRVAIGIHSGASIDNSAASTILDALLGQMAGGNLRQKMTLQLCGKDRSADHTFGVMVDTTGDLAAVQKAVRSWANATCVDMAYGAASQLDIDIVERPTPSKSDAATSGKSDFKLQARGDCRIEVVWRGSDCPSLARKCGISPQDFTRFNPKADLCSSLAEGQRICCSSGTLPDIRPKPSPDGTCAAYTVGSDDWCLKIAAANDLKVEDIERFNDKTTWGWFGCDNLLSGTKICLSEGKPPLPAPVPNAVCGPLKPGTRLPDSDTNIADLNPCPLNACCNIWGQCGITPDFCTAEKGPRGNPGTAPVKKNGCISHCGTDVANNGAGPDQFMSIGYYEAFNWGRPCLNMRAARLQKADYTHIHWAFGDISPDLSVSVNDSAKQWDDFRKLPQKKIISFGGWAFSTEPATYDIFRRAVEPGNRRRFIDNVVKMVVDNGLDGVDFDWEYPGAPDIPGTPPGLPTDGPNYLAFLQAMRASLPKGASLSMAAPASFWYLRAFPIDKMAEEVDYIVYMTYDLHGQWDYGNSWAQEGCREGNCLRSHVNLTETGYALAMITKAGVKSNKVAVGIASYGRSFGMSKPGCTDPDCHFDGAVDAGRGASSTAKPGRCTKTAGYIANAELREKLAQQETGARTWYDRGSDSNLMVYDNSSWVAYMDGDTRVSRTRHYRNLNFAGTVDWAVDLLDFSSDDGNPGGYDAEEWKDVPGLEPCDKTYGSLDDVAADGGIRPHCVDLYVLQALRSIYKDTMKSYTDMLNKDYAAKFDVYSHAVADHISKTMHDFIIKNGNKYFTCEVGELSVCCDECQQYAGSCPYCFKEGKCYSRYCGPDLEAPCLDSREMFSRRGIEGVVGPAPTSWKSNALVRRQRQLAIKQVRAAEPCPPDYSKHGYGYLPTDGSPPEGSIWWTLVKEDEFYAALLQETGVPKAKTAIGHYTRADTCPNGFPGADSEQGCAYLGYDYNIPVPDHYTAADVKNPKQIVEKAQEKSKNLDGDMEEVMAQIKADLFDGKVDEVVDSVSMPVLILQEAVHQMSQVVKAADEMTEAKRKAIIMAFIGAILFLVPVAGEALGTVAELADVAALVLVVGEAGNVAFDMYSLVEDADNGPLAILGIVLSPLALMRAGDMSRAAKYRRGMSAADVSKMGARVSGSLNTISSIRKRACRARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJL4</accession>
    <name>A0A367LJL4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6971</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJL4"/>
    <dbReference type="STRING" id="1330021.A0A367LJL4"/>
    <dbReference type="OrthoDB" id="337735at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20558">
        <property type="entry name" value="CYCLIN_ScPCL7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF117">
        <property type="entry name" value="PHO85 CYCLIN PHO80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="519" mass="55802" checksum="1A9A64C1D96E043F" modified="2018-11-07" version="1">MLKTSPPLAAARCRSSPASSPRSCPSARARRASSGLVVSPTSRPPSAPQPPRHACDKPSPLIGCSGTDPTAVSKRRGHSPSNPPSPTSPSSQAVAASAQRTSGQASSSKRPKANDPPPKLLPRRYELCAAADVVELVAHMLAELMATNDAIRISSGGLTRFHSRTAPGISVRDYLHRLARHATLTPPLLLAMVYYIDRLCALYQDFTINTLTVHRFLITAATVASKGLSDSFWNNTTYARVGGVRVAELKTLELEFLYRVDWKIVPDPEVLVAYYRGLIERTPGYALEPEAVAGDDAECMEDDDDITDGIDDGGEDGRCHDDETGSTSDHRLNSTDRALRRRGSVMRVDTILAALFAAFALVHARPRIARIYVQPIEDGATSAAPNPLAEISYDMTTLSLSSLMSYEAPEIPETAKLVRIGLYDASSRQWLAGTTVAAADNFSKGYSPQLLLVVDSQGGVVSVSCKGVAIDAGHTRDFGPKLVVLPEARGAQPQLNKPVVLSPEGSRVEPEQEKTFLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJM4</accession>
    <name>A0A367LJM4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Velvet domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_6978</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the velvet family. VeA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJM4"/>
    <dbReference type="STRING" id="1330021.A0A367LJM4"/>
    <dbReference type="OrthoDB" id="5384689at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034250">
        <property type="term" value="P:positive regulation of amide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051176">
        <property type="term" value="P:positive regulation of sulfur metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043455">
        <property type="term" value="P:regulation of secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.3960:FF:000001">
        <property type="entry name" value="Sexual development activator VeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.3960">
        <property type="entry name" value="Velvet domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021740">
        <property type="entry name" value="Velvet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037525">
        <property type="entry name" value="Velvet_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038491">
        <property type="entry name" value="Velvet_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572:SF14">
        <property type="entry name" value="DEVELOPMENTAL AND SECONDARY METABOLISM REGULATOR VEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33572">
        <property type="entry name" value="SPORE DEVELOPMENT REGULATOR VOSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11754">
        <property type="entry name" value="Velvet"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51821">
        <property type="entry name" value="VELVET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0749">Sporulation</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Velvet" evidence="10">
        <location>
            <begin position="26"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="223"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="475"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="231"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="291"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="385"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI14624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="517" mass="56654" checksum="2C77E8C3D0B55AAE" modified="2018-11-07" version="1">MATPASIPTNCSRDLVQCIHRVTRENRSLWYQLTVLQQPERARACGSGMKANSDRRPVDPPPVVELRIIEGPSVEDGKDITFDYNANFFLYASLEQSRSMAQGRVQTPAATNPPILTGVPASGMAYLDRPAEAGYFIFPDLSVRHEGHFRLSFSLFETIKEERDFDLHPSEAGDLPPGVDWRMEIKTQAFSVFSAKKFPGLMESTQLSKTVADQGCRVRIRRDVRMRKRDSKPNGFDRRDDDFSRRRTVTPAPDDLRRRSLSSSSEHRAPFSTTDAAAAPRQRPSLVVDTYPPPPPPPPPPPPPPPPPPPPPPPAAHPAYDAPRGHLSFGDTPRHMSHQVPSSPSGSYPPAQSPYGYHHPRTVGSACPSPALSANHEPHDRASSGYVTPSPSVYSSAADGHSRKDSHASFSATPLLPAPPAHRASKSRPSLAPLKIASLVSPLPPIEAQTEPLPTVSTGGKRKHEIVFPQSVQPLHNGRRQQDPYYGHPPGAFPDSGQGMYSRADGKMDVVTFSQWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJS8</accession>
    <name>A0A367LJS8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_6893</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJS8"/>
    <dbReference type="STRING" id="1330021.A0A367LJS8"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="2">
        <location>
            <begin position="177"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI14693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="276" mass="30099" checksum="263F2EE391928824" modified="2018-11-07" version="1">MTQLPEASSVTTVSLDRLAARDSDEMEKLLKAAAHPGYFYLDLGGEGDVAGQTRRLYAVADRYFDQPAEAKMRDVREGRPASSDRGFKSCVTDESFEMSTDEMRQGTLHLPTAMSEQGPAVNSFHERCHSATLLVLQRLADGLDVPLTQHHGGDESESGLKLIAEPAVARAADVVENKHRDSGTLTMLFYDAWSLHVCLSAEGEEPQRWTFVPPPPDGCALVHGASTLSRMTGGRLCAPLHRVTQPADGAAKRFFLSYFLRPDHRLSCDGPVACVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKH7</accession>
    <name>A0A367LKH7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7101</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKH7"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="60" mass="6902" checksum="CB147475BB0C62D8" modified="2018-11-07" version="1">MLRRGNIKPSYILCVDSAFIFIGFFKGRSGSNSYSLEIDRIKREKDSDSEDFVDLHLNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKJ2</accession>
    <name>A0A367LKJ2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7023</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKJ2"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="88" mass="10064" checksum="E75D2BB1368B75AF" modified="2018-11-07" version="1">MTDRKKSLHSRRYSLGFDVQIPETDINIILTLFNLPHDRGHFLALQANRQAPPCSLAFKGKMVDVITPAPVKKLLKWLRDQENPNQGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LL55</accession>
    <name>A0A367LL55_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerase II subunit RPB9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">DNA-directed RNA polymerase II subunit 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_6568</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LL55"/>
    <dbReference type="STRING" id="1330021.A0A367LL55"/>
    <dbReference type="OrthoDB" id="282270at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001193">
        <property type="term" value="P:maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10508">
        <property type="entry name" value="Zn-ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000008">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034012">
        <property type="entry name" value="Zn_ribbon_RPB9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="13">
        <location>
            <begin position="162"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI15117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="202" mass="22409" checksum="1FFE825A93EA69B6" modified="2018-11-07" version="1">MATPQSTASQDDNAGAKHEQITFRFCSECSNMLYPKEDKDAHNLQFTCRTCQYTEEASSSCVFRNVLNNSAGETAGVTQDVGSDPTVSELLPMFCLTCGVVLVCGQCSQPAAYMSVVKREDKRDEEPGFAHYVLAGSAPLYVDDDDDEYLEGDDMHAELPRSNKTCPRCNHQEAVFFQSQERSAETGMKLFYVCCECGHIFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLL4</accession>
    <name>A0A367LLL4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_6710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLL4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI15308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="34" mass="3721" checksum="0B43ED2146B78D2F" modified="2018-11-07" version="1">MATATARLRRTAATAVRAVRANRSSKACLLQQYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLN2</accession>
    <name>A0A367LLN2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]</fullName>
            <ecNumber evidence="3">1.3.1.124</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_6739</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a (2E,4E)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:45912"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85101"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a (2E,4Z)-dienoyl-CoA + NADPH + H(+) = a 4,5-saturated-(3E)-enoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:61892"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:85099"/>
            <dbReference type="ChEBI" id="CHEBI:85493"/>
            <dbReference type="EC" id="1.3.1.124"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.124" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLN2"/>
    <dbReference type="STRING" id="1330021.A0A367LLN2"/>
    <dbReference type="OrthoDB" id="2136131at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008670">
        <property type="term" value="F:2,4-dienoyl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05369">
        <property type="entry name" value="TER_DECR_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045017">
        <property type="entry name" value="DECR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43296:SF2">
        <property type="entry name" value="PEROXISOMAL 2,4-DIENOYL-COA REDUCTASE [(3E)-ENOYL-COA-PRODUCING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI15344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="302" mass="31716" checksum="34D2F9C3F4FF405D" modified="2018-11-07" version="1">MPVPESTYLSPVWRDGLFKNRVVFVTGGAGTICSMQTRALVRLGADACIIGRDEQKTKAAAQDITTVRRGARVVGIGGCDVRQMSSLKAAADRCARELGGIDFVIAGAAGNFLSSLEALSPNGFKSVMDIDAIGTFNTIKATMPHLLSSPTPRILFVSATFHYTGMPMQSHVAAAKAAVDSLMASVALEYGPRGVVSNVVAPGGIEDTEGAARLLSSDERARSSYAAGIPLGRLGTVRDVADVTVFLFSEAGSYINGQTIPVDGGAWRRQGGEGSALGGVEDPSMRYPQYLLLDDKKSKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLT9</accession>
    <name>A0A367LLT9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_6778</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLT9"/>
    <dbReference type="STRING" id="1330021.A0A367LLT9"/>
    <dbReference type="OrthoDB" id="270624at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000457">
        <property type="entry name" value="rRNA processing protein Pwp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044285">
        <property type="entry name" value="PWP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="264"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="400"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="48"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="499"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="69"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="513"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="533"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI15405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="543" mass="59071" checksum="E57181EB307B4D3D" modified="2018-11-07" version="1">MSIITTAQWVPRGFAAPFPKKYTLDEAEYDRIAGLAKLQLDDAQDDLKEAEAKKRKKSRDEEEAGDEMQTDHESRGSDEDVLKEYDLEHYDDDDDDESEAQTKGETMGMFGNVKSLAYYETNDDDPYITLQGDEDEDDGEELQIMATDNLILSAKVEDELAQLEVYVFEDEGDNLYVHHDLMLPAIPLCLEWLDMPVGKQGAAEAATGNFVAVGTMDPDIEIWDLDTIDCMYPNAILGQGGEAEAAKKEAKKAKKKKSKKAANDNYHVDAILSLAANRSHRNLLASASADQTVKLWDVNTTKCAQSYSYHTDKVCSLGWSAAEPTVLLSGSYDGTVVAADMRAPGAKAPRWGVEGDVETVRWDPHDGNMFFVSTDRGAVHYHDVRKAPRSAEATKSVWTLQAHDESVSSFDVNGVIPGLMATGSTDKTVKLWNISAATGPSMVVSRNLDVGKVFAATFAPDAAVAFRLAVAGSSGSMHVWDTSTNAAVRKAFAHRLPGRSETATAAEDRLIGVEDEDGSSSDDGEGPYGEGPYGEEGDSMDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLU8</accession>
    <name>A0A367LLU8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell wall proline rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6923</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLU8"/>
    <dbReference type="STRING" id="1330021.A0A367LLU8"/>
    <dbReference type="OrthoDB" id="5406427at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="601"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="728"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="795"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="926"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="64"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="439"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="530"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="803"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="859"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="876"/>
            <end position="893"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="962" mass="101364" checksum="B9D38688245298FE" modified="2018-11-07" version="1">MIATARGSSWGSAAGASHTHSLDDTAARPFVSTNLADGVAPDPSSTILDIPPPNPPFVFPGHQAVPSSAPSAPSRHGDRSLPVPTSSPPREAGDRPRKGLALPAFSFNPGASIGQEPEPSAFLSPPITPTSLSPRLLPSPVRPTRHGHRRGGSEFIGGSVRDGNSIALMSTSPTKSESGFASAPGLAPPSRRHTGRHLRGLSGAVSAHDLSQFSRFPAAHVIPRGSSAPNSPTYFTVVRDFPFPAHEKDLATPETLHLCRDAKISGDNTMAAARPTTPVSHASEAEPSSPRQSRQGRARVGFSDKLEFIPRPLSLVSSDTSSTATARPGHSVSGSISSVVSVASPVGREHATILPKSPARDLTDSRPSTAGAVLESLANASLECDATSTSPRRRNSTPTLLAVIEAQGPGQASNNTSTARPPKRWSFFGFEPSFISSAAPAKARPSSSCSSAESIRGVSGASSSDIESDSTETGREATVPGRQPSNKTSRKKRVKGWAGSILPRKPKSRRKQNSSTAAQQPAITATVDRLEDDEQETDGSETPGQDSPLFPSGDVEVSAVGQSTARGRRPSRDDTSYPMIDLDAALGPFNTPLPLNPEWEAAQRAAGSSGKRRMHSAQGMKNFSGPGMHYHRRAESAPDLPPFDMKRSGVHRFNSNSTMADVFEEDEDEDGVSAGKDPAAKRDTAMLPSLRRSVPNDVTGRYSKRSPAGGYGLAAAIALDATSRVVLDESEPDKKAAANASQAQFSRGSPRPDAVEETPSIIFCSANSMLGSSDAGLPSPKRSFAGHEAETYVASASMAPISPRSTTQASSAHGSPRSPMSQRMSTGPSSTDKNSLQSLLMGEPGPEVRISADYDMRSVASSNSTTTRDSGFIPSQRMSQPSLREQRPVSVSSAAFGRRRSSLVSLSRLISSAHGERSKLSMEVTMDNDNEVKKSKSVGSKTKERLGRMIQFWKPNKDGAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LM02</accession>
    <name>A0A367LM02_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_3467</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LM02"/>
    <dbReference type="STRING" id="1330021.A0A367LM02"/>
    <dbReference type="OrthoDB" id="62956at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="11">
        <location>
            <begin position="72"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI15430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="244" mass="28081" checksum="0D07A6AC520C69F6" modified="2018-11-07" version="1">MAAFINRHPRPRPRPRPRSRPSARASIIFAHDKTMHHPPKPSRSLLATTFLLLLLQTTSVLSHNIVLPAHGLECFHENLHREDTMTVTYQIGDREFGSAGNLDIDFWITNPVGGYEISEKTVSNGDHSFTAKHDGKYTYCFSNQHWGATSKEVSFNVHGIVYVSESDMPSDPIELEVRHLAELLAQVKDEQQYIIVREHTHRNTAESTNARVKWWNLFVIGVVVGESLFQIWWLRRFFEVKRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LM49</accession>
    <name>A0A367LM49_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RNA polymerase Rpb4/RPC9 core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_6527</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic RPB4 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LM49"/>
    <dbReference type="STRING" id="1330021.A0A367LM49"/>
    <dbReference type="OrthoDB" id="2186918at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030880">
        <property type="term" value="C:RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006590">
        <property type="entry name" value="RNA_pol_Rpb4/RPC9_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045222">
        <property type="entry name" value="Rpb4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21297">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00657">
        <property type="entry name" value="RPOL4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA polymerase Rpb4/RPC9 core" evidence="5">
        <location>
            <begin position="25"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI15332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="145" mass="16032" checksum="CA1D1E0BF9D6B29C" modified="2018-11-07" version="1">MSNKMSRPKPPPPGTEEASSTLNLGEFQNVDTLTLSEAALVLNALVAKRRNDRKNVNETDYLDHFARFTQKENVEAVERLLSSQKGLAKFERAQLGDNLALSSSAGSLCCENADEAKTLIPSLVDKITDEDLQELLDEISKLQNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMP8</accession>
    <name>A0A367LMP8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translocation protein SEC66</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3381</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMP8"/>
    <dbReference type="STRING" id="1330021.A0A367LMP8"/>
    <dbReference type="OrthoDB" id="73168at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031207">
        <property type="term" value="C:Sec62/Sec63 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018624">
        <property type="entry name" value="Sec66"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28229">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28229:SF1">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09802">
        <property type="entry name" value="Sec66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="137" mass="15495" checksum="14C86749958E1BA3" modified="2018-11-07" version="1" fragment="single">MSWFGVDWKGLALPFAYLVVLSSALMTFSSIYRKRKAAESANLAPWFPPGVRRQVYLSLLESSGSEDGSSEQQRRQVPDSVLCTALLRRAVEDIERLIHIRPAKQACSTLVLRGSVGDDLWQRIQRAESELEDELRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNL7</accession>
    <name>A0A367LNL7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_3049</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNL7"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI16036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="67" mass="7854" checksum="17CD62531D31F781" modified="2018-11-07" version="1">MVKTVLSLAVHGSLLRLTRERRERDLRLRERAVVWFALTPHTLPPGGRPHPLFNWLQWRSRGSRSDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNT4</accession>
    <name>A0A367LNT4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_1782</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNT4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI16105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="188" mass="20221" checksum="FA2A92B14F36DCAB" modified="2018-11-07" version="1">MPQVRSVPWQHTLLSFLSLIMRFALTIEGLVAVLAAGSSLYGVASGAPASSTSDVSGKAQGGKTPQGGKTPSGQNNDETKGILQLTSRKPWTKESVEGFLKDEKITAKTRPIVDQLRTAAESETIDQDKVKRLLGKLCYEGRQAEQAEKAAKQAKKVKGKGLPLFKGIFSKGLFFFNEGVLKASFFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LP20</accession>
    <name>A0A367LP20_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Autophagy-related protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L249_2999</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LP20"/>
    <dbReference type="STRING" id="1330021.A0A367LP20"/>
    <dbReference type="OrthoDB" id="346907at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14009">
        <property type="entry name" value="STKc_ATG1_ULK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000817">
        <property type="entry name" value="Serine/threonine-protein kinase ATG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048941">
        <property type="entry name" value="ATG1-like_MIT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022708">
        <property type="entry name" value="Atg1-like_tMIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348:SF22">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12063">
        <property type="entry name" value="ATG1-like_MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21127">
        <property type="entry name" value="ATG1-like_MIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="24"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="352"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="550"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="805"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="885"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="937"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="356"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="394"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="424"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="551"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="590"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="811"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="898"/>
            <end position="908"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCI15992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="972" mass="106133" checksum="EC214085FD3E9BC0" modified="2018-11-07" version="1">MASRQDAPSSSGSRRYNGRSIGQFAIDREIGKGSFAQVYMGWHTVRLPLPPSNLSFPLTPKQESKAAVAIKSVELARLNKKLKENLYGEIQILKALRHPHIVALHDCVESSTHINLIMEYCELGDLSLLIKKREKLITHPATHDMARKYPVAPNSGLHEVVIRHFLKQLCSALQFLRRANYVHRDVKPQNLLLLPSQAFRSQRAFHIMSASQDSLIPVAGLASLPMLKLADFGFARVLPSTSLADTLCGSPLYMAPEILRYERYDAKADLWSVGTVLYEMITGRPPFRARNHVELLRKIEAAEDIIKFPREVTVSSDMKTLVRGLLKRSPVERMTFETFFVQTVVTEDIPGLVEDDVPKPPRRELETIAQGKPLSSSPQARPSRHPAPIPLARDGGGGGGGGSSGGGPSMSPRELPRSPQSENHGGDGRPRRQTGDLHRVASSPRDVSQGLGIQRPQTQHAATAPTYAGQLTPRSSRDQMTGAAEARKPRAVSGNVRSAEEDKAAQDVMFERDYVVVERRHVEVNALADELAANERMGHGAQRATQMMRRCTQQGAPTSTTGAVPTPSSQTALVAQNRPAQDRRASYDKALSASPGSASSAITKAIQDASLRLFGFKMAPVRGAKGHSPPMYQPFPAYPTPVAPVGLLGEGRSSQFADEDVRAREAMEEYAERSDCVYGFAEVKYKQLVPMAPSADRGLGGISAEQLAEDEDGLTVEATVALSEEALVLYVKSLTLLARAMDIASVWWSKKSRGVTGSGVSAAVSEQVAHKINAIVQWVRQRFNEVLEKSEIVRLKLTEAQKLLPEDHASHPSNHGQDSVASSSGSGVKQVYLRPGISAEKLMYDRALEMSRAAAIDEVTNENLPGCKISYVTAVRMLEAVLEGDDDPTGRRLLSGKDPARGSPKEGSGDLDTDEEAHVRKMIKMITGRLASVTKKQQMIAEANSKEQQAQMQMARRRSGETVPRSLPSNTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPB4</accession>
    <name>A0A367LPB4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_1852</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPB4"/>
    <dbReference type="STRING" id="1330021.A0A367LPB4"/>
    <dbReference type="OrthoDB" id="269120at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015218">
        <property type="term" value="F:pyrimidine nucleotide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990519">
        <property type="term" value="P:pyrimidine nucleotide import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049562">
        <property type="entry name" value="SLC25A33/36-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45829:SF4">
        <property type="entry name" value="MITOCHONDRIAL CARRIER PROTEIN RIM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="34"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="150"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="266"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI16284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="38992" checksum="1FDD435CE418FCAF" modified="2018-11-07" version="1">MAQPHQAMGPGNGLPHAKLVPTGGGGRVRRLPFAESWVHLVAGGIGGMTAAAVTAPLDVLKTRLQSDIYQSQLQAKARALGPLNPARAAMHHLSDTLRILMSVYRTEGPRALFKGLGPNLIGVIPARSIGFYVYGNGKRLISHYWNDGQQAVWVHLLSGVAAGVATSTATNPIWMVKTRMQLDKNVAERSGGAMKRQYRNSLDCVRQIVRNEGVGGLYKGMSASYLGVAESTLQWMLYEQMKAALRRREARLQSSGRERTLWDKFVGSTGQVGAAGGAKLIAAVLAYPHEVARTRLRQAPLDPSNPKYTGLVQCFKLVWKEEGMMGLYGGLTPHLMRTVPSAAIMFGMYEGILRLCGTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPH8</accession>
    <name>A0A367LPH8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor TFIIIC triple barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPH8"/>
    <dbReference type="STRING" id="1330021.A0A367LPH8"/>
    <dbReference type="OrthoDB" id="414418at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051710">
        <property type="entry name" value="Phosphatase_SH3-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469:SF51">
        <property type="entry name" value="TRANSCRIPTION FACTOR TAU 55 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="32164" checksum="735496CCB0E1BB77" modified="2018-11-07" version="1">MSLERIYVVRHGFRSNWLVDPVTGVYTSHIPSPTGLAADPALTSHGVSQAEELAAHLAKLEPAVEAVYSSPFYRCMQTMGAFVNNSLIKIRAEQGLGEWFGLAPFSHPRPAPLHQLAQLFPSSSIEQSYRSVCVPEERGESLARLQARVSSTVRAIIRRSDEEGVRAVVLCTHAAVVITLGRVLTACVPPPESVDEPDFEAYTCGLTVFCRDDDVDDDDDDDDDDDDDDDDDDKDDQQQQHSRAHVSRSKMSTPGRFDCSFLSGGQERGWGGWARAGIDDDLSKARSNAVELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPT9</accession>
    <name>A0A367LPT9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_2869</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPT9"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="59"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI16397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="100" mass="11375" checksum="1752097656BF0CF0" modified="2018-11-07" version="1" fragment="single">MANKDPAYGLEWNPANGPKPGSKERGECFFPFLSSFLPSFLASPSAFPSLSFFPSSDGLILVEFFFVFNCFLLHSSLWVRFFSFPQFGDQKISFRRNEQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPX4</accession>
    <name>A0A367LPX4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_2661</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPX4"/>
    <dbReference type="STRING" id="1330021.A0A367LPX4"/>
    <dbReference type="OrthoDB" id="10250320at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20557">
        <property type="entry name" value="CYCLIN_ScPCL1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF10">
        <property type="entry name" value="PHO85 CYCLIN-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="3">
        <location>
            <begin position="84"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="233"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="237"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="284"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI16459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="393" mass="43546" checksum="4C0D7709A6D4AF59" modified="2018-11-07" version="1">MASRHLSRDELNKVALEHFVYQPVGRDMIAYLADAAHNVIACDSTLYPAGSSDSSSSSSDRRLPPTPPRSPSAEEDDSLPSLEDFITQLVVSSNVQVPTLMSTLVYLTRLKSKLQPMARGLRCTTHRIFLASLILAAKYLNDSSPKNKHWANYTHVTTNAYTFGFNRTEVNLMEKQLLFLLEWELRISEQDLYRELDVFLDPLRQRIVERHARKMRQRDEKLRRQQQDLYYPIPACSSSSSSSPSPSSSSSSSSSPSSSASPRSPRLSSRSRQASPDHQARTRGSLSPPGLTYSSSSSSYASSVASSRHPSRSTTPNKSHELLPPATAAATTSSANTMPYDSPVNIVVDPDLHQSLAYDMSPDQYLELQELSAKKRQKRGVWGRLLGGAVAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQ37</accession>
    <name>A0A367LQ37_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_2840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQ37"/>
    <dbReference type="OrthoDB" id="5426355at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI16352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="24627" checksum="D1712C8223185BB4" modified="2018-11-07" version="1">MAQLPITTIPPFSDVAKLPDCAKSCGPLYDANGACVPPAAPQADPAAYTACFCGHAKVAPFSTGTAGVCDSACTANQAGLHSIASWFQGICKESAPPANNNNNNNNNNNPNGGNVRQARPDDGSSNAPAAPANTGGGDWLSHHWQWVIMLVVLVVGIAAIWIGACVWRRRYLRNKDKLLLSQKPPNAGSTPSWGPAIAGSESATPMTFIADSERSFAEKPKSKDKVKWTVSQRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQ67</accession>
    <name>A0A367LQ67_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQ67"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="96" mass="10534" checksum="60CEAB5F888A1022" modified="2018-11-07" version="1" fragment="single">MDIIIHHSEASATTWLFKGGGAKKEDIDRAKKKKLPLLGIGNGTLFCFLEATTKATVMVKWVRTKANLIAERLRGEKEKGGKGRGRAKKAEGGPWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQE9</accession>
    <name>A0A367LQE9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Protein FYV10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_2964</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FYV10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQE9"/>
    <dbReference type="STRING" id="1330021.A0A367LQE9"/>
    <dbReference type="OrthoDB" id="1933455at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034657">
        <property type="term" value="C:GID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045098">
        <property type="entry name" value="Fyv10_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044063">
        <property type="entry name" value="ZF_RING_GID"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN TRANSFERASE MAEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12170">
        <property type="entry name" value="MACROPHAGE ERYTHROBLAST ATTACHER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51867">
        <property type="entry name" value="ZF_RING_GID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CTLH" evidence="9">
        <location>
            <begin position="163"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="RING-Gid-type" evidence="10">
        <location>
            <begin position="327"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="RING-Gid-type" evidence="8">
        <location>
            <begin position="327"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI16675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="403" mass="45402" checksum="752B4329D90C6750" modified="2018-11-07" version="1">MADLEHAALKHNEHLLLDQSLLRLPNELLRKNFRSAHFTIEKDTSSLKTLLKESATAAVSGRASQQDVLKNMDAIVARLRGVKRKLTVYAEQESRLHMHIAARISHLDDLYSIHTVEDVKYEAWSRRRLDRLLADYLLRHGFIQTATDLARERGIENLVDIDTFVNMSRIREGLLRGNVNDALAWCTDNKKELRKMESKLEFMLRFQQYIELIRTQSQPKLMEAIAHAKKHLVPYAAVYPKDVQQACGLLAYPPQNVASSAYADLYKPSRWAELADVFTKAHNSLLSLPSVPLLHIALSSGLSALKTPACHSSAQGEATSILGHGVCPICSTELNELARNVPYAHHTKSHVEYDLMLLPNGRVCGIQRLSDQAKKAGLPSDQVKDPRTGEIYSMKELKKVYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQI1</accession>
    <name>A0A367LQI1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein P1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">60S acidic ribosomal protein P1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_1909</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays an important role in the elongation step of protein synthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">P1 and P2 exist as dimers at the large ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQI1"/>
    <dbReference type="STRING" id="1330021.A0A367LQI1"/>
    <dbReference type="OrthoDB" id="2194681at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05831">
        <property type="entry name" value="Ribosomal_P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696:SF10">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="68"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI16647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="111" mass="11181" checksum="8C53801896499DEC" modified="2018-11-07" version="1">MSQNAELAVSYAALILADEGVEITSDKLQALIKAANVSDVEPIWTSIFAKALEGKDVKDLLVNVGSGGGAAAPAAGGAAAAGGDAAAPAAEEKKEEEKEESDEDMGFGLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQL2</accession>
    <name>A0A367LQL2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQL2"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="141" mass="15745" checksum="CE7E7AB8B698743D" modified="2018-11-07" version="1" fragment="single">MRASPRTISHKGHHERQQAGRRPEAVTHIRGRLQRQWESGGKEAQEGRQAHHHNRGRRRKRGQQTRRGSTQRPRGKPEGDRLAQQVPGTFYTIRAPATATGTPAAARSRGRAEPVLPALPLPLHLPACLRVEARLQPGRAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRJ0</accession>
    <name>A0A367LRJ0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">26S proteasome regulatory subunit 8 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_3215</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRJ0"/>
    <dbReference type="STRING" id="1330021.A0A367LRJ0"/>
    <dbReference type="OrthoDB" id="1664597at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000006">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000068">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000030">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="165"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="11"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI16970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="389" mass="43424" checksum="6DD04599EF1241DD" modified="2018-11-07" version="1">MALDQYYHNKIEAMKLEILKGQAALRRLEAQRNDYNSRVRLLREELGLLQQPGSYVGEVVKVMSTKKILVKVHPEGKYVVDVSDSVDVSKLTPGKRVTLLSDSYKLEKLLPSSVDPLVSLMMVEKVPDSTYDMIGGLDQQIKEIKEVIELGLKHPELFESLGIAQPKGVLLYGPPGTGKTLLARAVAHHTACKFIRVSGSELVQKYIGEGSRMVRELFIMAREHAPSIIFMDEIDSIGSSRVEGSSGGDSEVQRTMLELLNQLDGFEPTKNIKVIMATNRLDILDPALLRPGRIDRKIEFPPPSVEARADILRIHSRKMNLTRGINLNKIAEKMSGCSGAELKGVCTEAGMYALRERRVHVTQEDFELATAKILNKHDDKEVSLGKLWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRR3</accession>
    <name>A0A367LRR3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">5'-3' DNA helicase ZGRF1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_1805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRR3"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052800">
        <property type="entry name" value="DNA_Repair_Helicase_ZGRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018838">
        <property type="entry name" value="ZGRF1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28535:SF1">
        <property type="entry name" value="PROTEIN ZGRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28535">
        <property type="entry name" value="ZINC FINGER GRF-TYPE CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10382">
        <property type="entry name" value="ZGRF1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="5'-3' DNA helicase ZGRF1-like N-terminal" evidence="2">
        <location>
            <begin position="22"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="361"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI17101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="644" mass="70876" checksum="4253F89B11B88B3A" modified="2018-11-07" version="1">MSYAICRHEDDAAVAAPTSAPVLDYRCLFTHDLRRKQKRWQDGRLKYHTYNRRVMVYDDGGNLVGDMHAREGPLAEGDEMELESGAAAIVQVGECVGVRQQDLSGLVDRRARDFARRAAARRTATTTTTPDSRRVTPARGGVLGRAFIPQRSPFEERVRNEEGLKRRKRSASPPSKGGFARSLFGTRLTLSADFPTGRRTRVRGDGRGDVMVRREECAARKGEMARSSVAEVVRDEDDVARPRGKMAERSANICNGRIAHSAGEEDGVSTVDDDEPRVRRVTLEKVVAAPIPVARSAEPPTPNIERGIPLDIVPSTEPPGEDREAFMDEVCEDRGGGDAADGAWPPGSEVPSAIKAQIERTVDDAVSSNEIAVDEVCEDRGGEEAADEAWSSVSEEPSATEAELLPKKPMIEQAIPSDKLLSDEAIPSGKPISEDMSDDPTHTPVQAPPPPDGNRERGGNATNHNEPDNVPSRWSDRRRAELRIRSRQRRGLLIMSDQRRTESRSRLSRKKLTRNSSSSPERRQRPERRQRPERQPTPHAKLSPSPFRDAPAGFDSSDDGGRRSSGGDWSNNERRRPPKAVAAPRQQIRRSKKGPRIERLARKSTKSKEIFGLFSSAEAEAEVVPTAFALASNWSGLGGDGQNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRR7</accession>
    <name>A0A367LRR7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">L249_2127</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRR7"/>
    <dbReference type="STRING" id="1330021.A0A367LRR7"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019236">
        <property type="term" value="P:response to pheromone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13279">
        <property type="entry name" value="PH_Cla4_Ste20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06614">
        <property type="entry name" value="STKc_PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000768">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000356">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000535">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000005">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PH" evidence="15">
        <location>
            <begin position="82"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="CRIB" evidence="17">
        <location>
            <begin position="195"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="576"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="261"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="285"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="14">
        <location>
            <begin position="320"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="349"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="423"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="443"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="475"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RCI17087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="898" mass="97944" checksum="0A0ADEE986402505" modified="2018-11-07" version="1">MAQNSVYSSGQFMNPGPAPRPPGDRPRLNLTPNTANLPGNMSNMAMSPMRSTAATSTYSGSTISLPIVRQQSNNMDGKGGVAVKKEGWASVKESKNFIQPWKSKYLILRKESLDFHKAEGGKVAYTLYLRDVVNVGRVEQAGTIFEIKRKADGISSSPGDDDGQNKTLQIKVKSDDDLYEWIDLIYGACPGMGGVSNPTNFSHAVHVGFDPQTGEFIGLPPEWSKLLNSSAITKEDYERNPQAVFEVLDFYTDLAKRAENPTQFPTMTPTPPAPSQNKPLPYPNGGTSIVTPRPAPSTSGPRNLSYTSTSQQSAGTPQRRPAPPGEQQQPPPQRQQSPAMSTSYLSQDALREEQRRKQLEAQRQREAEEMQKRELEEYNASLPKTKVPLAQQEVGGYGGPPSAPAATDRDRFSPARPAPSPSKPAGSPANGLRAQRPAPPAPTTTGASSARPPASAQSSSSRETASQAARAAVGDNTSGPAAMRQQNGSQTSLARPPQSQSPAASRLPAPVKPLNVAPKPMQTQPSDSVKAAEAALTAKPPPTERKQDVRMSTMSETEVMAKLKEAVSKDDPNMSYSKQKKIGQGASGSVYVAKIKDTAQGIAREVLRQQGNRAQVAIKQMDLAHQPRKELIVNEIMVMKDSRHRNIVNFLDAFLRNNNAELWVVMEYMEGGALTDVIDNNPSISEEQISTICHETCRGLQHLHSQSIIHRDIKSDNVLLDARGNVKITDFGFCAKLTETNIIHRDIKSDNVLLDARGNVKITDFGFCAKLTETKSKRATMVGTPYWMAPEVVKQKEYGPKVDIWSLGIMAIEMIESEPPYLNEEPLKALYLIATNGTPRLKKPEKLSKELKAFLSVCLCVDIKSRASADELLAHDFLKHGCPLASLADLLAFKKHTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRT4</accession>
    <name>A0A367LRT4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRT4"/>
    <dbReference type="STRING" id="1330021.A0A367LRT4"/>
    <dbReference type="OrthoDB" id="3836772at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016902400" evidence="1">
        <location>
            <begin position="20"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI17128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="250" mass="25394" checksum="8B91D5CC05037BE1" modified="2018-11-07" version="1">MKYAYSTFMGLVLAAPALADGYYSKSSAPAPYSTTPVIGLSCPQACENGFNACRSKPGANISTCVSERNACLATCGLDDTDEDEYSSSSAPGPAPTPYPAPKPECKTCKDSKPVIGLSCPQACENGFNACRNKPGANISTCASEKAACLATCGNGPIPPAPTPYPAPQPDCGKACEDKFNACRSKPGANISTCASEKAACLAACGQKPAPTTSSAYGDETSAPVYVGAGDSIKPTVAAWTLGLGALLMLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRY6</accession>
    <name>A0A367LRY6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_2246</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRY6"/>
    <dbReference type="STRING" id="1330021.A0A367LRY6"/>
    <dbReference type="OrthoDB" id="16816at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050602">
        <property type="entry name" value="Malonyl-ACP_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090:SF1">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="3">
        <location>
            <begin position="110"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI17215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="344" mass="38152" checksum="7CDCFFE8104D5337" modified="2018-11-07" version="1">MISYHNSVFVDVTFGTLPRRTYAVASAGALRFQVFNRRTKWLQKERAASCPEDSRQADYLKDEVATRLTERLSYISRRFPRALDLGANSCNIARALAQNKIDGSVPDSPPLSSRIGQLVAAESSEKLLYRDADDEFNTKLNITRTVLEDEESIPFEAQSFDLVLSSLSLHWINDLPGILSQINMVLKPDCPFVGALLGGDTLFELRTSLQLAEQERLGGMSPHVSPLADVRDVGGLLQKAGFKMLTVDVDDIIVDYPDTFALMQDLQSMGENNAVLGREMGPIRRDVLVANEAIYRALHGNADGSIPATFRVIYMIGWREDANQPKPLPRGSGDVNLKDILEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LS16</accession>
    <name>A0A367LS16_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LS16"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI17245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="166" mass="17670" checksum="6AC4B477E62FE5B3" modified="2018-11-07" version="1">MRKGPEDSVSMEGRAGKASATWFAVLHDTWGGQVILTGGRERCMQAVVTLRSSVLGGRRERTWTAALIEGEEDGKGKGGRQYGLPGEGEKEKINKAGVEDHTAKLVGKQGVRKRSGKGQALEGEKTESSVDTRYTEAEVGRSQTRPGEQQACVSEADAGHCSVVGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LSH6</accession>
    <name>A0A367LSH6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_2267</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LSH6"/>
    <dbReference type="STRING" id="1330021.A0A367LSH6"/>
    <dbReference type="OrthoDB" id="4928226at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016704822" evidence="2">
        <location>
            <begin position="16"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="727"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="790"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="459"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="727"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="811"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="887"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="924"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1035"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1078"/>
            <end position="1091"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI17359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1117" mass="108805" checksum="F28AE0133E46CBF2" modified="2018-11-07" version="1">MKGALVLGLAALSEAATIRRQESTQDANQTFNKDCLVAINSHVEEGKVDGFCQTVIGKREVDVSQLKYGRPNPLKTSCHNFDEMIKACRHAQWKRDEAEPSKDPETGDEAPKDTEDEDDDEDEPPCTTAPADGSGAPKTTSSADDNATETTSTPDDKAPETTSAADEAPKKTPAADEAPETTSAADDEAPEPTSATGEESPETTSAADDEAPEPTSAAEEEAPETPSSADDEAPETTSTDDDEAETSKPIVPVNGTTEAKTTSAAAPAVTPPSPSSHPTGFLNSTNAADTGKAPVDGSFSNAAGIPPSPSSHPTGFANSTNAAATGTPSVDGSLASSNTTSTEEKADEKGEEETNAIGPAVPTEATTELLNVLKQCQIEIRFGLFVIVQASIPAEHRSLAASVSVRLVQDITVSVTQPNMYFEPCAPADHGRVVTRYQDQYFYGSSVDVSASASASASASMGATSGNSDANFGSSDASSETSTESGSGSSDASSETSTESGSDSVAKTDAGASSGGASGNFIVLCISGTSQLLIRVENKVVVETKPAPQELAQEKGNLVQHCSGVNQCQQAPCQGEECNCNLVIKAETKTGAGADAEAGAGAGATSDAGVDADADAGAGAGANAGAGIDAGAGAGANAGATSDAGIDAGAGAGADAGAEAGTTSDAGVDAGADAGAGAGAGSTSYAGVDAGAGADSGANADATDAGADATSDAGVNAGADVGAGANAGAGSVTSTTTSFEPCSPSSDECRGIQVCTDSCTVHKAAQGEAPAPVPVTQVRKVTIIALKKVSHDSEEGQEATVSQTGGNTSGKTKKPCRKGGKKSLESGSVIGEKHDQVDKSASGPQPGSASEVGAEPASPASPQVGSLGGAAGPDALGSSSGSAPEYGSPASAPESGSPGAAVEDTSSGPSAGPISGVAPSSDTPSSAPESGSAGSAPKTDSPASAPASGSPDYAPESYAPESDSPASPSEPGSPASAPESGSPASAPESGSPASAPESGSPASAPESGSPAPASEPGSSVPAPESGSRGSAPEYGSFAGSAAEGGFVSPGSPADCPPGSRPECDSAGAPEPTGFAKTRISSPGSGNSTAPQFVNAASGRVAVTLHFLAGLVGLALFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LSR6</accession>
    <name>A0A367LSR6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PAN-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_2936</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LSR6"/>
    <dbReference type="STRING" id="1330021.A0A367LSR6"/>
    <dbReference type="OrthoDB" id="5151222at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006583">
        <property type="entry name" value="PAN-3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08277">
        <property type="entry name" value="PAN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016562353" description="PAN-3 domain-containing protein" evidence="2">
        <location>
            <begin position="37"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="PAN-3" evidence="3">
        <location>
            <begin position="75"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="200"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI17461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="630" mass="68622" checksum="532D564CDAEDD5ED" modified="2018-11-07" version="1">MCIRIAALDKKWRTMIASCSLGFALPLLATLTGASAEEWFDLCPGKDGLSETTGYGREVTYHCGQRFPQEHLLETVTTSDADSCVSSCVGSTDCVGSQWTSGHNECQLFSEGADSLEASTTEQGNVIALVLSPETLLTVTKLDEQQTVMGVHDSYSGQDGGSSAETSDSRSCRSCKKLLTECESSEEKLEADVRTCKKGTEAVEEKLKKCNESNKKAESDKKALQKEISGLKHKMHLCPKPLNQKQVCPTYKGSLLRQGGATWRVSCQQGPYGGVLRTTGGSFEGCAEACAKDGKCKAINYWSNRKAPCTMISQIKGMGSVVRDPLGKYSKMCVRKHYGSKTTMIPPCLMQWTVGEPRADQRPSRGEDTWGCKPPRLIVVLYAHIDGWTRGRIRSVEVSHTSALGFFFSRRLNTRLWFPFHRGDDDASRRFPSRRRCGGNDPLCYPDGYHGSVHDRHPLRAGREGILSDEGMDRVFVCVCVCTETEKETENVVTDVAETSVAPVNTADYPSIRWSKEAVPYPVSASVASPVSASIAGPVSASIAGPATAPPNGTVPSYTRLITASTTGSTAVAPPALSYAICVPARSSWSVFTAAFVFTLSEFKYIKYWKRDKGEKRSPSKHCSPSSCRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LT94</accession>
    <name>A0A367LT94_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RmlD-like substrate binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LT94"/>
    <dbReference type="STRING" id="1330021.A0A367LT94"/>
    <dbReference type="OrthoDB" id="6235964at2759"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048269">
        <property type="term" value="C:methionine adenosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048270">
        <property type="term" value="F:methionine adenosyltransferase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05254">
        <property type="entry name" value="dTDP_HR_like_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000357">
        <property type="entry name" value="Methionine adenosyltransferase 2 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005913">
        <property type="entry name" value="dTDP_dehydrorham_reduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029903">
        <property type="entry name" value="RmlD-like-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491">
        <property type="entry name" value="DTDP-4-DEHYDRORHAMNOSE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10491:SF4">
        <property type="entry name" value="METHIONINE ADENOSYLTRANSFERASE 2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04321">
        <property type="entry name" value="RmlD_sub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RmlD-like substrate binding" evidence="1">
        <location>
            <begin position="5"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI17402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="317" mass="34621" checksum="769C3545000FEF67" modified="2018-11-07" version="1">MAQRSVLVTGATGLLGREVVKAFQLGGWKTKGTGYSRADGIDVLRIDLQKEDEVGRALDESKPQVIVHCAAERAPDKVAKDPQGARALNVAASASLARLAAERGTLLIYISTDYVFPGTAGEAPYEADATPRPTNLYGQTKLDGENAVLDEFARAGKHGLGVILRVPVLYGHAETPSESAINSLLDSVWKAQTQGIEMTMDHWARRYPTNTEDVGRVCRDVATKFLEVGSRESLPRILQFTSEDEMTKYDICRLLGDMMGLSTEGIKPNTQGNEANSSAQRPYDCHLSTKTLKGLDIDVSTCDFGAWWRREVGAFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZ70</accession>
    <name>A0A367KZ70_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amine oxidase</fullName>
            <ecNumber evidence="6">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_4551</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a secondary aliphatic amine + O2 + H2O = a primary amine + an aldehyde + H2O2</text>
            <dbReference type="Rhea" id="RHEA:26414"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:58855"/>
            <dbReference type="ChEBI" id="CHEBI:65296"/>
            <dbReference type="EC" id="1.4.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="6"/>
    <dbReference type="EMBL" id="LKCN02000028">
        <property type="protein sequence ID" value="RCI07470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZ70"/>
    <dbReference type="STRING" id="1330021.A0A367KZ70"/>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097621">
        <property type="term" value="F:monoamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050703">
        <property type="entry name" value="Flavin_MAO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563:SF14">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="7">
        <location>
            <begin position="123"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="143"/>
            <end position="144"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="543"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601613-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI07470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="591" mass="64231" checksum="9412C8F076359395" modified="2018-11-07" version="1">MAVMATLAPLVRARNCTPGINYCGSSLRAIAHGVNYDEQIREQLTLNGQIINEKTMQNSLFFCEGGRNGNIVLRKVCSYKDLDMCLDMGLGKDDKCMVAQRIHFSGITAAFQHVDVAIVGGGLSGLSAARNLAAAGKTFTILEARGRVGGRVLNAKTGPSGVQEVGAEYLGPTQDRTLGLAASLGLKTYKTFDDGNTTVWRNGTVSTFLPDPATGGLLPLRPEALAQVMPVVEELGKLAAEMAVDSPWDHPSAEEWDSMTCESYLRSRLNDTDALFVFDLIFEAVLSTTPSEPSLLYWLSYIASAGNSTMPGSLSRLLTTKDGAQESRIVGGTALLATKLAERLGYRNIRLNAPVHRIVQGNKHVSVYWNDKMLTADHVVVAMPPPLAGRIAYEPALPARRDQLTQRMPMSSIGKAIAVYPKPWWRKEGVNGQALSDSGITRATFDNSPSDGSYGAIMGFIGADSMRGLDLEEEDKVEELFVADLVRYFGPQAANTTDFILQRWDLEPYSRGGPVAYGPPGLLTKFGPFLRKPFGKIHFAGTETADYWVGYMDGAIRSGERVAKEIVGNFNNNYSNNNNNNNHNNNKSRSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZG2</accession>
    <name>A0A367KZG2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1605</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000026">
        <property type="protein sequence ID" value="RCI07557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZG2"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI07557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="90" mass="9770" checksum="89F6667E8BB7EDE7" modified="2018-11-07" version="1">MHYTPRTVHTHPFQGLPPSSLTLPIRPRNCGNRIPTAFIANTPSRHPQGSYQDPKGPCSPSPPLKKTIIHLYVPTGGGLWRQAPGSLIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZP4</accession>
    <name>A0A367KZP4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_1613</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000026">
        <property type="protein sequence ID" value="RCI07634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZP4"/>
    <dbReference type="STRING" id="1330021.A0A367KZP4"/>
    <dbReference type="OrthoDB" id="5411141at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="434"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="579"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="100"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI07634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="623" mass="68343" checksum="D257326A78AA05B5" modified="2018-11-07" version="1">MVPAGTPCGHGTSLPSQSSPCRFIVFPPWTRDDDDDDDDKARHLEVKRHRMTKRDSRTGVRSRRRNSQEKAPRGAAAKRADSSSSTSSDDSDNGSDKKQNQNQNQNQNQRQQDTITPPISSPDAIQVPDPLALSSKPRPPPLPLPKNKEEFTPTQTLESTLSPLNTLERGPERGPPPGAVSKAEDGDDRRHREHNDKKEDHDENDEHEEQRYRANGPASPQSPHFSDFGPSFPMVTAPPGLGPPPFGDFPFPQSTEERKALQPVVTVTESAASSGTPAPADPIQTPAPMVVHHGLHSNAEKALIAVGSIGATVIVFFVAWFAWKCYKMHRRSHQRDFWQTRAAPSTSLDDMAHSSGTSRRSDFQSSLGLNRPKQFMMNLASRVPFLKERVAMRSWSNLDKQHDDAVWAEKRLPAQGHQRTSSGITVHTAIMTKSERGGESSATWSLPHQGGPMQRQSRPTPRSNNTLSGISDVSSLSSGFGDGDIIMPPAVIGTATTTKVTAVAVPPPVASRASVSTASRSYRDTVYTEASEDVVPRFRTINSWVRQQSGRIKRAKMTASDAPPLPNGPLEQDFRLMMPDNEEPRRVDETTSPSGYVDESEIIAGYSPTELASQPGYDMPMAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L038</accession>
    <name>A0A367L038_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_5680</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000024">
        <property type="protein sequence ID" value="RCI07795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L038"/>
    <dbReference type="STRING" id="1330021.A0A367L038"/>
    <dbReference type="OrthoDB" id="1047367at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF172">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="18"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI07795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="461" mass="50464" checksum="878ACD770EEA2945" modified="2018-11-07" version="1">MSPSRSNNNNNNPGWRQLDIAVVGGGIGGMSAAIALRRAGHRVTVYEKSDFAGEVGASVSCAANGTRWLHEWGVDVQRGQPVVLKKLINRDWRTGEPVSVYDLDDYEERWGHVYNLFHRQDMHAMLMASALGDQGRGLPAALVVNHKKQKKCASIQVEDGIISFADGTVARHHLIIGADGIGSATRSAIGIKPEKRPSDQSCLHANVRTEDAVKAGFVDYSLDSALEYWGGQDGSWDKIVLSPCHGGRLLSYYCFFPRLKGDYAGHAWASGDDRPVEELLAPYPELDRQVKGHLSVGHEIRPWRLWLHDPYPYLFRGLVCLLGDAGHPMMPHQSQGACMAIEDAAALGILFGPDCFRGDVSEALSVYQEVRLPRVTRVQTAAAKAAYNINERIGFSANKDTPTYKVEDAGQILTIEEMNAYDLHMDIKQRLAARRGVHSPAGFIHGLPIGLKLPSGITIGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L057</accession>
    <name>A0A367L057_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5682</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000024">
        <property type="protein sequence ID" value="RCI07791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L057"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI07791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="158" mass="17887" checksum="5BDB0187EADB1F69" modified="2018-11-07" version="1">MRTKKDYIHGYTSIGLTRISLPPNHRSSKYVRVLQVGTLKYLEKIISISFSHLLNTNTSPASNSSSIASFRLSRDSSSSSLLPRVQLSDSGYLYTFNLFFTAFLFTFRPTNYLIRTLFSDAFQQSDPLFLKKFPLSATIGNDQKYSFAKLSGSGNYTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0A6</accession>
    <name>A0A367L0A6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7707 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_5827</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000023">
        <property type="protein sequence ID" value="RCI07837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0A6"/>
    <dbReference type="STRING" id="1330021.A0A367L0A6"/>
    <dbReference type="OrthoDB" id="2121879at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056124">
        <property type="entry name" value="DUF7707"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38118:SF3">
        <property type="entry name" value="ANCHORED CELL WALL PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38118">
        <property type="entry name" value="ANCHORED CELL WALL PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24808">
        <property type="entry name" value="DUF7707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016629851" description="DUF7707 domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7707" evidence="3">
        <location>
            <begin position="65"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI07837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="231" mass="23509" checksum="939A46198B2B21AF" modified="2018-11-07" version="1">MRAFTTVIALGAAVATAQLSSTNYTSELEMQIDPNSVPAKERGQYLDDAHSLLSMTFHADKTLTVAMWCLAQTNTCGQLCDNNTSKNSCLQDKLEFDCICASNNSAPGLQFYTQTIPTFKCETLFSQCNSQNVGNADGQQGCINNIQNLCGKAAPPKASSGGGSSGGDGGDSSDSSSSTAASSASTPSASQPGNNNAVTTTRSGGLAPPTKAPAANGVAFAAALGFLAVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0D9</accession>
    <name>A0A367L0D9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_5735</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000024">
        <property type="protein sequence ID" value="RCI07682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0D9"/>
    <dbReference type="STRING" id="1330021.A0A367L0D9"/>
    <dbReference type="OrthoDB" id="1684102at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005302">
        <property type="term" value="F:L-tyrosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03062">
        <property type="entry name" value="TRX_Fd_Sucrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000067">
        <property type="entry name" value="Transmembrane domain transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009737">
        <property type="entry name" value="Aim32/Apd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF666">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06999">
        <property type="entry name" value="Suc_Fer-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="449"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="474"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="516"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="549"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="596"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="638"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="661"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="694"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="333"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="227"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="290"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="301"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI07682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1068" mass="117254" checksum="57FECE9B96FFECA1" modified="2018-11-07" version="1">MSSPKNYQSSSPAPGHSRSFSSSIPRGDLTARLAEPIRSGQRSASPVPEGESPSLVGGRPCAQGPGVSALAAALSDSLGQSPPRFGTPPARVVSPPLRADTPINYGSFDSRSRLGQNGAAAPLEDPEIVKRHLVQPGESENLPSEESSTQGPVRGKQAAEPGTGLNDNEFSSLRLQGGDITRGIYKWTEQAEAKGRLHRSRSFHHQRPEPETDVLDINSIKIPGGFRRNHLRRNAMSPNRQTEADESGVESPPGTQPRLFTSSFLEFLTIYGHFAGEELEEDDEALGPNEEFWSDRAGLGDESDDDREPMEDSALLTNSKRMRRRKPRGGSGKNSPMNAALLLLKSFVGTGVLFLPRAYLSGGMLLSNLVLLCLAGLSYYSFVLLVSTRMRVEGSFGDMGGILYGKWMRNLILASIVISQIGFTAAYTVFTAENLQAFIRAVSDCRTTISIPILILMQTLIFLPFSLLRDIGKLGFTALIADAFILIGLAYLFYYDVLTLSKFGLADIIMFNDKDWTLFIGTAIFTFEGIGLVIPIQESMKHPQKFPRVLFYVMIIITVVFITMGAISYAAYGSKTETVVLLNLPQDNKLVNGVQLLYSVAILLSTPLQIFPAVRIVETELFTRSGKYNPYIKWQKNIFRFFVVMLCAAISWGGADHLDKFVALVGNFACIPLVYIYPPLLHYRAVARNRAWKIADVVLCIFGFFAMGYATSLTIMSWANAGAKPPGYCERRNLWFATKFTTVPKCPEAPCWCEDETPMPSKLDIDRESSLVGTVAPYAEQILVCTGRSDWPSKIEVDRGGNNLVAELRMITRRAGQSHGPLPPVSIVYSSFPSSLGKRRNMAFVSAYMFPSFKYAPWLLRVSGDIRYDRNAMILSQLSTQNLAASFVLPAAHASLACPSVAPEAREASYREFKDNLQDVRDVMVLICGHGNRDKRCGVMGPLLQKDFNTKLVKAGLDVRDDRVDVVQSGSEEAHKVLPRGVAPQAVRVGLISHIGGHKFAGNVIFYLPPGMLLRNGGPHPLAGHGIWYGRVEPKHVDGLIKETILGGNIVADLFRGGIDPQREMLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0J4</accession>
    <name>A0A367L0J4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zinc/iron permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_7850</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000022">
        <property type="protein sequence ID" value="RCI07955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0J4"/>
    <dbReference type="STRING" id="1330021.A0A367L0J4"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF55">
        <property type="entry name" value="MEMBRANE ZINC ION TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G00470)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="251"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="477"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="520"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="332"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI07955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="541" mass="58336" checksum="6F47E3A1BFB9372D" modified="2018-11-07" version="1">MICLNKADDVSSTHLAFNQSPPALSPSRTTRQDLNGISNLRQYVEAGQDTASSPGLVGNATDDDLHPLRRPPAPSCHGLTSFEIDSGRERRFCLSWLSSLPHHPERLWTLTAWILSLLFLYYLLPILAGFFNSGNHLLPGPYVAPAAAAAPARAPLAKRATCHVGGVDQTEYNTSLHVAALLIIWFVSTLGCSFPIMAAKLPWLRIPRRFFFAVRHFGTGVLIATAFVHLLPTAFISLGNPCLGSFWTEKYPAMPGAIALASIFLVTVIEMLLHPSRHAHPPDHSTGEDGMRPAQYLCSGTAGLPFSDLKGSRSARSTTLALGMTRLKNSPVMESEAAEIENGQPSRENEAESEPKSGPADSGGAGSTDAGLVSPDLLRRKERLQCILLEMGILFHSVFIGMAVSVSVGADFVVLLIAIVFHQTFEGLALGARISAIEWGSKKWQPWCMALAYGCTTPLGQAIGLATHTLYSPDSEIGLIVVGVMNAVSAGLLTFASLVELLSEDFLSDQSWRDLRGKQRIIACVLVFFGAFFMSLVGAWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0N6</accession>
    <name>A0A367L0N6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Actin-crosslinking protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_7832</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FRG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000022">
        <property type="protein sequence ID" value="RCI07988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0N6"/>
    <dbReference type="STRING" id="1330021.A0A367L0N6"/>
    <dbReference type="OrthoDB" id="5539371at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23339">
        <property type="entry name" value="beta-trefoil_FSCN_fungal_FRG1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008999">
        <property type="entry name" value="Actin-crosslinking"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010414">
        <property type="entry name" value="FRG1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12928">
        <property type="entry name" value="FRG1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12928:SF0">
        <property type="entry name" value="FSHD REGION GENE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06229">
        <property type="entry name" value="FRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50405">
        <property type="entry name" value="Actin-crosslinking proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI07988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="29668" checksum="B37296BECADF6E4F" modified="2018-11-07" version="1">MVKPLTFKGDKKPKKRKRADGNEAPRAAKQQQQQQQKDEDDASLDDDSWVSAEAVTDLIGPVIIVLPTEKPSALACDAGGAVYAMPLENVVDDDPATAEPHDVRQVWVANRVAGTESFRFKSHHGRYLSCDGDGKLSATSEAVSPLESFNAIATADTPGTFQLQTLRQTLLTIEASSKANAGAEVRGDAQVIAFDTTFRIRMQARFKPKIRVSKEERALAKISRSELEEAAGRKLTEDEIKLLKRARREGDYHEKLLDIKVKGKHDKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0U7</accession>
    <name>A0A367L0U7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_7869</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000022">
        <property type="protein sequence ID" value="RCI08055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0U7"/>
    <dbReference type="STRING" id="1330021.A0A367L0U7"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF15">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016942220" description="FAD-binding PCMH-type domain-containing protein" evidence="5">
        <location>
            <begin position="19"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="54"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI08055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="511" mass="55988" checksum="EB728AEA031C8387" modified="2018-11-07" version="1">MLSTFPLIGALFVASALTTDEACLKKCLQLAQVPSYFKDQEQFSSLSRPFNARLPFTPAAVVTAESTGHVSEAVKCASSCGGFKVQARSGGHSYASHSLGGQGGSVIIDLASLNQVKVNSDTSAAVGGGVRLGNLDKALFDQGKRAISHGTCAGVGFGGHSLHGGYGFESRLWGLSLDHIHSLEMVLANGTVLNASSTMTDDLFWAVRGAGESFGIVTRFNIRTQAAPKSLVYWSFNLSDATKDISTAVASLYHLQNFALNNTIQDRRLSWGWFLNQTRLLFRGKFHGPLDEFNQRIAPEILRGLPDLAESFRTVREVNWLQSQALFNHGTDEISKLYQPDKPGQYSPQNNFYAKSLTVPDPLTKEALTAYVTYAKEKGTKVKKSSSWYSTGNLYGGPDSQIDIYNSLWSSYGSRGSLWVFQNFGSVKLEEPFDSSLPEFVQGINDAITENMPHARFGAYANYIDPALSAREAHYLYYGPNYNRLLSIKKAVDPEDIFSHPLAIGVDDDYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L159</accession>
    <name>A0A367L159_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000022">
        <property type="protein sequence ID" value="RCI07952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L159"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI07952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="58" mass="6062" checksum="D82B688B2627C050" modified="2018-11-07" version="1">MTWLYVIPFRLSGAITAISTARRSLAPIDMTAALYSAPIAITIAITSRSGAITAIAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L261</accession>
    <name>A0A367L261_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7907 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_8884</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L261"/>
    <dbReference type="STRING" id="1330021.A0A367L261"/>
    <dbReference type="OrthoDB" id="3515453at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057229">
        <property type="entry name" value="DUF7907"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25484">
        <property type="entry name" value="DUF7907"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016976576" description="DUF7907 domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7907" evidence="2">
        <location>
            <begin position="23"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI08519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="200" mass="22218" checksum="8CEE2CCD2D16022C" modified="2018-11-07" version="1">MKLIITISALLLGSFVTADDVQSKPFNLVIQSAADKVLNRQRFSACHSGAAIESFCVSGRFGADFYFNTTEGSQTPIPGYEPPGVIVWNLPLGGEPNHVSEPMTFWNDPSTNVALPLLQPGNDRQYVTFDKDNQLAIFSYLDDSHTPPTGNELKPLKNWFVCQTYYSGYRYLTLAWVMGNGSAKPQNPSCVKVEVERRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2N8</accession>
    <name>A0A367L2N8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">L-serine ammonia-lyase</fullName>
            <ecNumber evidence="5">4.3.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_4835</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-serine = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="5"/>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2N8"/>
    <dbReference type="STRING" id="1330021.A0A367L2N8"/>
    <dbReference type="OrthoDB" id="7773036at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06448">
        <property type="entry name" value="L-Ser-dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000040">
        <property type="entry name" value="L-serine dehydratase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF2">
        <property type="entry name" value="CATABOLIC L-SERINE_THREONINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="11">
        <location>
            <begin position="12"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI08700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="340" mass="36171" checksum="86B04796529C6165" modified="2018-11-07" version="1">MGSLGSEAKLPWHQTPCVLSPQLTRIAGCNIYLKLDNLQPSGSFKSRGIGNLMTRAAALATGRPVHFYCSSGGNAGLACATSAVALRRPATIVVPVTTSDMMKNKLLDLGVQVQQVGKNLAAADEFLRTELLANDPDGVYVPPYDHPDVWDGAASIVAELRDQLDQPMDAIVCSVGGGGLFNGLMQGIETFPWSGAKPDVVCVETDGADSLNASIRAGQHVTLPEITSIATSLGCSRVSKQSWKWIQRPNTHSLVVSDADAAMSCVRFADDARHLVEVSCGAALATVYRGDLRRCLGRGLSDEEWAGKNVVLIVCGGSGVTLAILDQYRREYGHMTSIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L311</accession>
    <name>A0A367L311_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_4678</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L311"/>
    <dbReference type="STRING" id="1330021.A0A367L311"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000213">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="9">
        <location>
            <begin position="27"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI08815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="570" mass="62712" checksum="937EF04AA76B4F8E" modified="2018-11-07" version="1">MQSLVEPQRSLGFKNRKKRGAALLTVRIPYQDGSLTGRSLLGIETFSGIPYADAPVGPLRLRPPRPFSETLSGRDRPVLGPAPACPQMFFSHRRDDDDDGDPLLQTVISDVLKLPFLRPLAGQEDCLTVTVQRPAGTKAGDGLPVLFWIYGGAFQLGATNTYDAVNMMRTAVAQHQPFVFVAVNYRVGAFGFLAGREVLRDGSANLGLLDQRLALEWVADNIDAFGGDADRVTLWGESAGAISVFNQMVLYGGNATHRNGRPLFRGAIMNSGGLVPTAPADCTKAQAIFDAVAREAGCAVSANVLDCLRDVSYDTFFHAATSMPGLLSYDAMALPYIPRPDGLVLPDSPDVLLRTGRYHAVPTIVGTQEDEGTLFSLLIGRLPGTRHIVDRLTRDFFFNTSRSDLTDFVNLYDDDDSARGSPFRTGFFNELYPGYKRVAAILGDLVLILTRRIGLAMALKGRPDVSAWSYIASYNHGLPFVGTFHGSDVLRLFYDVLPDQATASCRTYYLNFLYNLDPNKGVTKYAFWPKWADGHELMWFKTAHENGILKDDFRSRASDWIAKHLPVLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3I0</accession>
    <name>A0A367L3I0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">COP9 signalosome complex subunit 3 N-terminal helical repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_5076</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI08958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3I0"/>
    <dbReference type="STRING" id="1330021.A0A367L3I0"/>
    <dbReference type="OrthoDB" id="29061at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055089">
        <property type="entry name" value="COP9_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050756">
        <property type="entry name" value="CSN3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF1">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22788">
        <property type="entry name" value="COP9_hel_rpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="COP9 signalosome complex subunit 3 N-terminal helical repeats" evidence="2">
        <location>
            <begin position="212"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI08958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="490" mass="54261" checksum="A47293CF93E1AAB9" modified="2018-11-07" version="1">MDDAKLVLGSFPAGALDADDSAWKKYDTALRQYASATLKLSREARAAVLADPVPFLQMLDPAKNTIGNLVLLDILYSDDAELPSQVLERTVEFLRNFDPRQVTYVGGLLLSLLERIGSGKILPPDLSVELLASTIMRLNQVSLFTSTHLMLAKLAHATNASEQALPVLKASVVFYPTVFTPRDVRHVLCDPEPLYSSSNSTKSAPLTDPLRSTTVMEYNLLRGLIYISREDWGRAQDAFEQVLTHPCRNKNVGIMMADAYKKWLLVGLLYRGRAPVFSSLVSPAMQTNLTTVGEPYSGLASLFSTTRVADLRTKFETHRQTWQMDGNMSLVEEVMSAYQKWQIKKLKYIYTRVPLSEVQRTTLDAETGKPLADVQTTEALVRSMIASGTLGGEIEPAADGGESYLAFGSPMASMTEEDVALVINKSWKSVSELREAYLSTDQRLKWNTDFVRHAAREQKRAEVEKEADAAVGFETQVEDEDLMTGVLASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3P5</accession>
    <name>A0A367L3P5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA polymerase delta subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_4956</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI09055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3P5"/>
    <dbReference type="STRING" id="1330021.A0A367L3P5"/>
    <dbReference type="OrthoDB" id="514823at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904161">
        <property type="term" value="P:DNA synthesis involved in UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.20">
        <property type="entry name" value="DNA polymerase delta, p66 (Cdc27) subunit, wHTH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019038">
        <property type="entry name" value="POLD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041913">
        <property type="entry name" value="POLD3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17598">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17598:SF13">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09507">
        <property type="entry name" value="CDC27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="138"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="243"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="307"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="322"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="362"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="380"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI09055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="416" mass="45728" checksum="E0DBA45D9547DC20" modified="2018-11-07" version="1">MDEPTKFLADRLLSQERPITYRELSRALNVHVNTAKGLLYDFNKCQNARRQGSIHATYLLAGVKSPPEEADDMPSSSAPESPAEPPQTMTLALVGEEKLEDILREYREVTSIHIYSLAASRQTDVALLADVANSVSEALKDEPPSDTSKYGTITNPLMRRRRDPRASSLGGGSKPVRQGRAAQVFKAEKEEPVSDASSKDATHPTKRNSPPKAIQQEKSQPEKSQAIKSEKEPSVKAGKAPTTKRSNSGNIMQSFAKAASKPRAKPKPPPKEETLAAALSDDGEADDSDVLSPSDKKSSAAAMEAAMKSKKDRAEKLKRMMEEDDDDDDDDDDDDVDINDVDDEPDAKDNQLDEDEEMVDVAEPKAEEKVAEEVASSGNGRRRGRRRVMKKKRILDEQGYMGKVFSPVIPRLTIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3V4</accession>
    <name>A0A367L3V4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5042</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI09097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3V4"/>
    <dbReference type="STRING" id="1330021.A0A367L3V4"/>
    <dbReference type="OrthoDB" id="4928187at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="445"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="659" mass="70968" checksum="BF00B6AC4B567329" modified="2018-11-07" version="1" fragment="single">LGEAEQGGLGVSLVVERGGPSLWAHDFDKVTDGIIRDTTDAEQTMLADFVILATSLSALLVTAEEFAFPSTDVPVGCARICGPVIEAVDKCRGETGKTKQLKRQVPVGGNVVAVWLDKDGNWIPDDVIEDAQWGPIVMVDDDDDDDDDLGFDEDDDGALSANLGDGKVRAATSRSSRREEREIRRAKRRAQRALRKKLEEERRIAQLTPNNGRGRAPINIGNGGGNRADDQTTVVLTLIFDKSKMTMTATRSLQTISPGPGGGRTGAGAQPFMVPGPGSFAFPGEPANVFPGKGFVAPAPVRAHYVSDEDGFFYFYSLFDNVNQLLGSSVVLDFFEALYGYGYYLDPIVIGINNFKGFCHSLYGKGIINVIINNKSIFQTTAAPSTTAASPSTTEETLRTVTPGDEVETYHVNIISNSHWKNICCPIYDRGFLFPLKRYFENPTSSTRTADTISTTTAAPSTTTAPPSPSKDTLRTVRPGDEVEKPTATEDDETTATRKPQTKAAPGAAAEVDGTTEPIATSGKRLSTEENCVCRIESFDIARTVALCSSCIAQQANSAAKQKSRLDFFLSFFSRPVFILTLFKDINEIMNRCGFQPLEFKPADVASVQGVRVSVAKSSDGEVDAKSSSSSSNEAPHTSPAMASALFWAVAATLAAWRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L445</accession>
    <name>A0A367L445_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L445"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="72" mass="8453" checksum="56316D769E742952" modified="2018-11-07" version="1" fragment="single">RQAAFEILHGVWMEKPCRLTTEHKTTSGLEEQKEEEEEEEEEEEEEEEEEEATRHARASYYNILPKGSACLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L446</accession>
    <name>A0A367L446_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_1525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L446"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI09213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="66" mass="6892" checksum="D94A5D2E4F958BC7" modified="2018-11-07" version="1">MLAHGHESERRGGEEEDEEEAHATPSHANPATGWSGLWAFFVLFLFVVPGRRGGGGGGEGGGDEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4P8</accession>
    <name>A0A367L4P8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Golgi apparatus membrane protein TVP15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_3686</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
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            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000015">
        <property type="protein sequence ID" value="RCI09405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4P8"/>
    <dbReference type="STRING" id="1330021.A0A367L4P8"/>
    <dbReference type="OrthoDB" id="423534at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013714">
        <property type="entry name" value="Golgi_TVP15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28128">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28128:SF1">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08507">
        <property type="entry name" value="COPI_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI09405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="14163" checksum="9DAA5EDC7975762D" modified="2018-11-07" version="1">MAMELSDTFRIVNLGVGAITVLGGIAQIFGFKLQTIVVGAYMIVFGLAIALLEFQIPPQISRYASFLFSFIGRGAFYIFIGCLLLGGMILQNIAGGVVGIVGLAYVVLEFIPSIEPPANMREADVGGWSAEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4S1</accession>
    <name>A0A367L4S1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_3665</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000015">
        <property type="protein sequence ID" value="RCI09435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4S1"/>
    <dbReference type="STRING" id="1330021.A0A367L4S1"/>
    <dbReference type="OrthoDB" id="3365399at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF12">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06440)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="41"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI09435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="483" mass="52750" checksum="FDC45C5EE8204D36" modified="2018-11-07" version="1">MTNKAKSPIVTNSSTADYQVKFHVDDGDNPGNWPAWYRAWVMVTVSFSAWVVVLYSTSYTSTLPRLQDELKVSRLAAVMGLTTYMTGLALGSLMAPPLSELYGRRVVYLVSLGFWSLFIVPAALANSMTVILVARLFSGLFGAALISNGPGTIVDVSKPDHLASGMSLYSLGPFNGPVLGPLIGGFVSERLGWRWANWIVLILGGVSLAMMMTVKETYGPEILRRRAGRLRKASGCRDWWCQYDHDYLSTSLFRVNLLRPCVLFFTEPIVWFINLWNALVYGVLYLCFVAYPVVFSHHRGWGPGPTGLSFLGIGFGIVLAIVLEPLIRRSINGPEAAALVMVFGSLLTPVGQLGFSWTCLPETIHWSIPILFGVPFGAGNTLSFIYSSNYLAGAYGIYAASALASNAVIRSLFGAALPLAGTKMYETLTPQIAGTLCAVLEVALIPIPFVFWKYGSRIRDGSKAIRQLRENAVVDEEKRGQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5J3</accession>
    <name>A0A367L5J3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_3977</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5J3"/>
    <dbReference type="STRING" id="1330021.A0A367L5J3"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF13">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="19"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI09700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="271" mass="30521" checksum="9F7987E5AA683402" modified="2018-11-07" version="1">MSSAVPDYEVVEYHYYYPRGVLDILASGTSAFIGEVNDSTILKYPLEQGGDLSRIEHEYKLLKIIGPHERIIAITEQGLTNDGLYLERASNGTLLDFMSESREHALSLRKRIAWCREVVEAVAYVHSKNVIHCDINPANILLDDKLHIRLADFQGCHLGDSGEELLPALVGEPCRYFCPRNEDSGASRKTDIFALGSTIHFIVTGEEVFPDIIAGEEDWDERVRSRFASRAFPDNSHPCASITRKCWMQQYMSASEVLGDVKKVEQLNGWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7E7</accession>
    <name>A0A367L7E7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7053 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7E7"/>
    <dbReference type="STRING" id="1330021.A0A367L7E7"/>
    <dbReference type="OrthoDB" id="3246050at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055481">
        <property type="entry name" value="DUF7053"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38117">
        <property type="entry name" value="NACHT AND WD40 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38117:SF2">
        <property type="entry name" value="NACHT AND WD40 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23155">
        <property type="entry name" value="DUF7053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7053" evidence="1">
        <location>
            <begin position="7"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="168" mass="18732" checksum="6DA59B385C4FB812" modified="2018-11-07" version="1">MSTTSRCRVLTTTTALPPTATRSAAERLLHSHSSMIDLNPLVRSRQRLSSAPASAPAEERGADYEWYAITDRLCLCLRVTYTASFRDGEDGALATHTFAPLGLRVRGRWELVFLDGQERTLAVRETVVLQCSPLLVPFVRATLKRAHRTLVERFSERVLTMGGDVGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7F8</accession>
    <name>A0A367L7F8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7F8"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="114" mass="12631" checksum="3DC8D180688DE8AC" modified="2018-11-07" version="1">MRWRAPAAGFGDARHDDGTWPRCTRSARRPHSLLPPSLSHLSLSLSLSFSDGSERWNTAGFYTRGVERGLCKVAFIPPTPPSSPPRLPFRNKTQKQGKGGVCLKEWEKDNTGPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7K6</accession>
    <name>A0A367L7K6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_4393</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7K6"/>
    <dbReference type="OrthoDB" id="10605586at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI10400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="320" mass="35938" checksum="D3EF04B2E7ED7509" modified="2018-11-07" version="1">MAFASNLPPYIDDPSFQVTLFRISMAKASWHPLRTQVALTKHTPLLGTVMDKGELQPPPASTAVKKSQTLPHHSVLPFRNRPPLHLSTSMAHPLLHFLLLTASWITTSQAQRLPSGQNDPKPCTVPTDDAYYCAHVCLGAGGTQTWRNMTLSLSDWSKGWRTGRISYGHSSTACACVVRVFHPKPKSQEDGRCLARCVTAGGVWYNGRSRKPAGWRVTMYPDGDIFCPCLMLENFDGEEGRWEEGLPLLYSEPPPEAKASGVENWWYVSNLSQSMNSKPRSSESWRILQSCLWPLSIQAAIWHSWTRKKRRETIPHSSQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7R1</accession>
    <name>A0A367L7R1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Required for respiratory growth protein 7, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_4327</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7R1"/>
    <dbReference type="OrthoDB" id="20734at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018828">
        <property type="entry name" value="RRG7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28133">
        <property type="entry name" value="REQUIRED FOR RESPIRATORY GROWTH PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28133:SF1">
        <property type="entry name" value="REQUIRED FOR RESPIRATORY GROWTH PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10356">
        <property type="entry name" value="RRG7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI10451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="254" mass="27580" checksum="4C73A9AA84071F25" modified="2018-11-07" version="1">MLTIRQGCALLRRRPPTAPQPVACRLTRYYMHSQSTDDTCKLPDASSAQHSDLASFVDYAQRYGVNSQSTVYVGTHYEYTVAESLARLGFSLRRVGGASDLGTDLVGTWALPTFPRPMRVLLQCKAGVARVGPHYVRELEGAYTGAPAGWRGNDVLAVLVCERPATRGIRNSLGRSRWPMAFLCCSRRGHLSQLLWNGRAEDEGLEGLGVAVRHADDATTPSQLILTCNGVTLGRVDDDGDVPAAVEGDFSLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8P5</accession>
    <name>A0A367L8P5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8P5"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="61" mass="7120" checksum="EA38195BCCB090BE" modified="2018-11-07" version="1" fragment="single">QRLQRGRVRTYRGHSGRVIAVIAARVQLSNSGYLYTFNLFFTAFLFTFRPTNYLIRTGYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9V3</accession>
    <name>A0A367L9V3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SAGA complex subunit Spt7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_7586</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9V3"/>
    <dbReference type="STRING" id="1330021.A0A367L9V3"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05510">
        <property type="entry name" value="Bromo_SPT7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22927">
        <property type="entry name" value="HFD_SPT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000072">
        <property type="entry name" value="Transcriptional activator spt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000032">
        <property type="entry name" value="Transcriptional activator spt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006565">
        <property type="entry name" value="BTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037782">
        <property type="entry name" value="Spt7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47343">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR SPT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47343:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR SPT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07524">
        <property type="entry name" value="Bromo_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00576">
        <property type="entry name" value="BTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Bromo" evidence="10">
        <location>
            <begin position="356"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="101"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="250"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="455"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1056"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="150"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="180"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="455"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="466"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="483"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1095"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1133"/>
            <end position="1143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI11208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1182" mass="128642" checksum="7601EB9773DB8B55" modified="2018-11-07" version="1">MSPHSGQPAWPPAALHFSAAARCLNPLDDGPARIQTPVDSAMAMMMPEASSVDADEENRRVLFADLYRKTELKVALLFAPDGSYNLDAIAALRRHPPPCTVPVALPPTTDHEPIKEPPLKKAKRAIDEDDYDDDDDEGEGEGEEDEGNDDAAAAAAAAAAAADAAPPVHKPPHAANALLSPSKSGSSPVHSVNSPGRQARAQESVQARPRPGDQGIEKLEEARIATEEAARRSFHTIFHTLENDSTAMLEQQRLEDSEKQLQAEMENNNSSAHAGGAPNAAQGSLSSANLGASSLTLKHLIARIDMKRDQVLASDAELRLLMNEVRKNRSKWASEENVNQEELYEALEKVLTELKAHTEYSTPFLSRVNKRDAPDYYNSIKNPMDLGSMTKKLKSLTYKSKSDFVTDLNLIWDNCLKYNQDMNHPLRRMANGMRKEAEKLIPLIPDLVIRSRAEVEAEERRKQNGGDDDNGDDSDDEPIMSSRGRKAATKGANKSRKAPSDQKEETPVMDQKPMLQVNGLLGKPGREGSEVVDGSNGFATPPIGGGGGGGGSITPGGIANGHVGNVDAMDIDGPSMNGMTLNQAFRQAAEQVYEDEEYKIWKQSTKRDRALVAKERHLLFKDNNNGLNVEAPALLRTKAGMRRFLKHQKEAEGLGLASYPYLLGSAPSADKEAGGKPSETLADGIVEEEVEKVVPDYYDTLSNIPDIQPNVQWVEDGEGQVINQHEEFLRLVPAGLFTAPRSRLTKKMDDNIRQIQETRKLATKISVVKQMQVQSQVYSNQFPKSNIEPFVEQDVEAHFIADDGPAMAAEACQDALKRSVAKILYLQGFEELQPSAMDTLTGVAAEYFQTISRTFNSYREAEKMTVQTAEGPQLRARFTPEEVVLHTLEENGHDVASLEAYAKDDVDRLTSKLGALHERMKLHLTDLLRPALSADAGADGVGAFKDGSDQFMSGDFAEDLGEDFFGFRALGLDKEMGLDSFSVPFHLLHSRVRNQYQMQTQVTGGGMSLDTFEALSPSDPVTKDSIQDDIGLARNFFLAKLHANGDQALVEDEDLPVKQRKPRPRLGASGKIMSAQKRPPKEQLALAKKKKKMELAAAAAAAAEKNHAGPNNTNNNNNMGSGSNSSGKRRIGSLTNGTASTAGPPNPALVALGASMERTESAQSQTDKDDNTGMMSPESIAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAC0</accession>
    <name>A0A367LAC0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7668</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAC0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI11370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="120" mass="13480" checksum="C74E90F5586EE655" modified="2018-11-07" version="1">MDACAPAPPPTHSNKDGYGKMPLSKLQSICHCRLFFFTLSGVMEDKGAELQVVKQATHLFTLLPPLFHQLLIFNPDLHKTPNPRKLRRKPKPVAFISAFSKQTPIHLSSFQISNSQGPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAC3</accession>
    <name>A0A367LAC3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7665</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAC3"/>
    <dbReference type="STRING" id="1330021.A0A367LAC3"/>
    <dbReference type="OrthoDB" id="3641511at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="42"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="195" mass="21984" checksum="C738A79FD8DE15C9" modified="2018-11-07" version="1">MERVCLPNFPTAADGLRKAAEQLELCDHLPAVDNGVRMLQKMDAIMDRLDQLGQKVEALDQKVDALDRRVDALDRKVDALDRKVDALDRKLDQKVDALDQKFNALDQKVTTLNRNALVRQRNSHVIRGDMNLVPPYSVLTGEVIEDFPRNIDELGRLPVREIEKLLRSLGETVAGSAAEKKRSLSWACGLLSREF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAF7</accession>
    <name>A0A367LAF7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Translation initiation factor IF-2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_7540</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAF7"/>
    <dbReference type="STRING" id="1330021.A0A367LAF7"/>
    <dbReference type="OrthoDB" id="361630at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03702">
        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03692">
        <property type="entry name" value="mtIF2_IVc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000008">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10050:FF:000001">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000019">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_B">
        <property type="entry name" value="IF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053905">
        <property type="entry name" value="EF-G-like_DII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044145">
        <property type="entry name" value="IF2_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006847">
        <property type="entry name" value="IF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000178">
        <property type="entry name" value="TF_IF2_bacterial-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF20">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22042">
        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04760">
        <property type="entry name" value="IF2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="12">
        <location>
            <begin position="677"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="148"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="261"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="380"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="661"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="976"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="176"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="208"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="298"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="396"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="456"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="469"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="487"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="500"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="538"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="571"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="979"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="991"/>
            <end position="1002"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI11418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1218" mass="132945" checksum="EDF699B1BAA0E855" modified="2018-11-07" version="1">MSRSQRPPSLEIAPKVGEILTQNVKKMSKSCLCRDSNPQKTSPPALHLRLVSTEALICLVILATEPQLVYVQPQCSSLEPGSPDSSAKSSAVGIGAASSGGVGSLANKGIGSMASADKLGGSSPSHAPPILHGLLPHELAARESMARKSIPTPAPTPQPQSQNALPRSGVGMTRSNFDRDPSRTEIRPSRPAASGDPSRWDPQPRSPPNQSWTAVSRQQSPTQGTPSAAQGSNSPAIGRQQQQQPNNALFTEVGFSGYWRAENTTGAPRPVDGQQSPVKRSWSDAKTPDSWADGVDNVLSTAPTQTSTAGDEQRPSQNSPPTASRLMPETGGKQQQLAVPKPRRMGAFSQLKASVSGSANSEDILLPWKGGWDALKRAGQTPEAVKKTAVPENAQELKTTPMSVSKPATNDPQKDQAFWDEWEMRTSPQKGVLQVERQQREVRQNETWSEEKKQGSEQQHGELNNNRRGAQERQVQDQPTQERRNETLLSPEQQRSMESVQEKQLHGERSKERRAPEDMGDQRPLSSLDSAQEARIKASSKKQKKPRKKSFRREDEDYEDYVIERQERQQQQKAQKKASQSQEEGGEKKEAPPTRKIFIPEFINLHDLAKALKQPVDRFMRDLEHMGFANITSDTIMTGETAGLVAAEYEYDAEIDRGAKKDLSSRPAPQDMSSLPSRPPVVTIMGHVDHGKTTLLDRLRKSSVAAQEHGGITQHIGAFVVKMSSGKAITFLDTPGHAAFLSMRQRGAYVTDMVVLVVAADDSVMPQTLEALKHAEKAKVPVIVAINKVDKPQARVDQVMRDLASNGVQLEEFGGDVQTVRVSGKTGEGMDELEESIVAQSEFLELRTETDGLAEGWVIESSVKPTGKSATVLIKRGTLRPGDIIVAGKSWARVRLLLNEAGGEMAEVPPATPAEVWGWRELPPAGELVLQAPDEETAKTAVAYRMEMADRAESSLQLAEHEQRLRELAAKKAAEEEAAAAAAEAAEAGIEPPPPPPPPPEEPGVLYQNFIIRADVIGSVEAVSGIVLELGSNEVRPRVLRSSVGQISEFDVDHAAASKAIIINFNSPILPHIRQRAAMAEVRIMEHNIIYRIADDVTTVLEDLLPAMVSHRVVSEVDVLQIFTINVKRRITRNIAGCRVRNGVMQKTSKVKVLRRGEVVFDGLIDTFRHGKKDVQSMGKGTECGIGLQGFDAFEVDDQIQGYEVITEKRTLGGRRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LB69</accession>
    <name>A0A367LB69_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Succinate dehydrogenase cytochrome b560 subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_7722</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LB69"/>
    <dbReference type="STRING" id="1330021.A0A367LB69"/>
    <dbReference type="OrthoDB" id="588261at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03499">
        <property type="entry name" value="SQR_TypeC_SdhC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.10">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase, transmembrane subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034804">
        <property type="entry name" value="SQR/QFR_C/D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014314">
        <property type="entry name" value="Succ_DH_cytb556"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000701">
        <property type="entry name" value="SuccDH_FuR_B_TM-su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10978:SF5">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01127">
        <property type="entry name" value="Sdh_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81343">
        <property type="entry name" value="Fumarate reductase respiratory complex transmembrane subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI11669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="167" mass="17977" checksum="41CC66E2AD9BA7DF" modified="2018-11-07" version="1">MISQKVGLAALRPRAHKNKSPVATTKVAPEQGQEILARQRLNRPVSPHLGIYKLEQTWFGASAWTRITGCTLSGAAYVYFASYLVAPLLGLHLESASLAAAFASWPLLAKGAVKFALGFPFSFHFFNGIKHLVYDMGVGFAKSAIKQGEMALWITSVLGGLVLAFGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LB70</accession>
    <name>A0A367LB70_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_7354</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LB70"/>
    <dbReference type="STRING" id="1330021.A0A367LB70"/>
    <dbReference type="OrthoDB" id="442921at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd16116">
        <property type="entry name" value="Ubl_Smt3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000155">
        <property type="entry name" value="Ubiquitin-like protein SMT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022617">
        <property type="entry name" value="Rad60/SUMO-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10562">
        <property type="entry name" value="SMALL UBIQUITIN-RELATED MODIFIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11976">
        <property type="entry name" value="Rad60-SLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="105"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI11678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="187" mass="21048" checksum="C1B34E114D13FB20" modified="2018-11-07" version="1" fragment="single">LLFNTSHSQVSEQKPPEILGRLLSITQRPRQTDLGPALSPTNHRRPRPKPSTNFKACCGRSSPCPPTFPCQRTSVSLLTTRGQFAMSAEREASPDHQQEPPANSEHLNIKVTDNNNEVFFKIKRSTKLEKLMNAFCERQGKNITSVRFLFDGTRVQPTDTPDSLEMADGDTLEVHQEQVGGWRYTTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBC4</accession>
    <name>A0A367LBC4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBC4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI11727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="88" mass="10267" checksum="35ED65EFFE6A2E1E" modified="2018-11-07" version="1" fragment="single">GYLGSLNQKVIQAVDKELTNREEAIKEELEAGEVFVLRRYFSRYFKVPTCSTLTYLYKIGDLEEDLYVPYPAVSAVLRGVWVRIRLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBF7</accession>
    <name>A0A367LBF7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_7149</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6252103at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052779">
        <property type="entry name" value="WDR62"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45589">
        <property type="entry name" value="WD REPEAT DOMAIN 62, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45589:SF1">
        <property type="entry name" value="WD REPEAT DOMAIN 62, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="781"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1050"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1131"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1508"/>
            <end position="1666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1791"/>
            <end position="1817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1850"/>
            <end position="1919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="97"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="808"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="877"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1054"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1236"/>
            <end position="1246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1262"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1285"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1311"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1345"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1379"/>
            <end position="1392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1395"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1412"/>
            <end position="1422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1425"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1435"/>
            <end position="1447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1513"/>
            <end position="1529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1584"/>
            <end position="1600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1616"/>
            <end position="1629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1643"/>
            <end position="1652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1878"/>
            <end position="1887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1908"/>
            <end position="1919"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI11763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1919" mass="203498" checksum="3B5A58289B738000" modified="2018-11-07" version="1">MASSNNRLKLTPSNSPFPPRTAKTPQRGRTPQESTKLSLKRVVGTTCRSPTGFDSVNSLFAYKAGAAVVVVDVRGKKYSQRFFRARPSAVPLQPCSPATTTTTPKTTTPKANDSRNRVAPSFRDIDLADSPASRTWTRRERIKAATCLALSRDAKYLAVGETGYAPRVLIFSLADASSDTPLVSISEHAFGVAAVAWSADSKYLASLGAANDGFLCIWKIDPRTGAAKLFQQNKCTSYVRSMVWRGHSLITLGVRHVKVWKVDGAPAVSQTAQRPLAGRNVLLGDLLLETNISCAAVDGERLIMCTDTGDVCVLEEDDERQTKLIKVLTLDFPITAVNISGDVAYVGGRDGHFATLDVPAVMRRGSSCVLTVAEAPAGIVALACLDNMLVTVDSRQSIDLWTADQTPGQKADAVVRIPIPGHGEPVAGVQALKRLDSAGAAFVTWSYSGTFTYWDLDGQVKSTAEVAVDAVELDGHVEFVNQLTCARTTSNGQLLVTADRLGILKVTDARSNECLLDIKAHSSDCKSICIFDGDGAGGDDDDKFIMACCGRDRTAQLFHRRASGSIEHFQTLEFAAKVVQVLVPSDGKIITCSLDRTVQIHDLVCKDGDPDVMAALPSRVISLRASPTSMAMSQDGRSIFVSLLDRSVFQFDLATGRQLCCFKCTDEGGVESTVLESLTVGNWGPQDAEFLLGSSNTDKSVRIYDAHSGSFLDREWGHTESINGVCLVEDDDGSKKVVSVGSDGTMMVWSLDANDRCCSRDPSPAKDSPVGRPTLRRVLSKADLADFQRPSAGRQSPPRALQHRTSRLGLATSSRMSSSALQASPCPGGTMTGGDNASRRRPSSSAQPDSPPPSPKTRNCRTHSLSVGSKGVRKKSSSSSSLNGFGSLNMATEQACRTMRAYRKKLSSAEPITADGLTELDHELRLTIAALGDRAIRTQAINETVLSGLLDQEIVAPIHLARRKGPLGRWRGGPWGMSGAAVYTPLESLFLFQSLLGQGIDAGAFVRISELLKNNAIIKSGETYDPSRLTPDALQQLFLRLLREELKCEGQAASSSPSSSPGGSWKRKLGSPPLPSLRDASQHIEKLPALIDRLYARYRDSIVEQIREDERQFVAVQGQIQALEKTEKERLAKAAASQHGTPVLAPRDGGRPSYPPSHQSPVPIPGPLGGIRRTSSVLNTPAPAAQPAVVPPSHAPAATPLARPPSSAPSKPLNGSSSVLQPPAGLPQAASRVLQPPAPPPKPIISPRPESASKSHDGSGGSSATATTTTTKTPTGGILKWEKPYQPPQTGQPPPLATLLQQSASSPHSKPQLPQQRQEQQTGQPPKPTAPGMASRPTTSKTAIPPSPPPPPSPPCQAPGPLAAPMQPVPSRPATGPLTPQPTTPVIPPGRGFPPSTQVRGTTPRSLTSASPQPPPPPPPPKVTAATSQKRSPTVAQAAQRASVLAAPSNKPQTAQYAVQAPRPAVPEHIIRQAATAAAATTPAAVRVSPLTAPRTPVAVAPVPLTRGFGTKWASQSTPSTPGPQTAEQESPAYEPVSPPRRAASIVSDTPKTARKTRPKPATYQPEPPTTRPRGRPPRNAPTSSTSSAGGNRRSQSVASQADELSMDHPMLPATIKKEAQTPRTHDDAGDTTADESAYGRTHMTTPGSVSSRMAKRKRQETPSEPLAPPVQVLWTRGFTKVSSSALDQISSHRHANMFATGVRERDAPNYRQIVLQPQDITSIRAAIKLGNKAATQAAASLPGGDPGTASVWLPVSEDLVPPRGIINSAQLERELVHIFCNAIMYNPDPDRGPGAALMKRSRGGGGGGDDDDDEEEEEAFGYHVDENGVVKNTRSMFVEVEKLLGDLRSAEKERGVPPLSSSSGGARQASVATPADDTAEDEDELAGDGVINTSTPTAAAVPTGGVVKRRRVGGRGMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LC42</accession>
    <name>A0A367LC42_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_4588</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000008">
        <property type="protein sequence ID" value="RCI11987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LC42"/>
    <dbReference type="STRING" id="1330021.A0A367LC42"/>
    <dbReference type="OrthoDB" id="10675217at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005249">
        <property type="term" value="F:voltage-gated potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005404">
        <property type="entry name" value="K_chnl_volt-dep_Kv3.3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01582">
        <property type="entry name" value="KV33CHANNEL"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017067002" evidence="2">
        <location>
            <begin position="24"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="403"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="437"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI11987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="470" mass="47020" checksum="D811A05E9D7BB84D" modified="2018-11-07" version="1">MHLGAYSALVAYFIVLVTGLAHGATDHKLHARHGGNFRKMAHVKQFIPAQPLGGGGGGVGGGGGGPLRNGGGPLRNAAARKGRMNHGGNLDQGNNLNNNLNNPGNNLNNNLNNLNNPGNNLNNNLNNLNNPNNNNNNNVGGGFNNNNNGFDNNNNNNNNNNNNGGGGGGFNNNGDLAQANQGQTLCSPNQIRTDIQVITETVTQTTTVFGGAQAAATSGANINNGGNNGNNNVNGGNIGNNNVNGGNIGLNGVNGNANNGAFNGAQGSAILVDGARRAPNGNNGGIAVINGNGLQNGVGNTAPNGIAVITLDNQRIGQSGIQVVNGQSQCVINGVVMGTLQDNGNLNNNANKNNNNNQEQANGPAAKIIPLPSNLASGSSTTTTTSAAQQQAPPAATQPPPTSSQAPPQAQVQAPQEVPQQQPPPPPPPPPPPPPESSSSSTSSSADPSSTGSPVRSSGLNLGALVSGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LC84</accession>
    <name>A0A367LC84_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_0531</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LC84"/>
    <dbReference type="STRING" id="1330021.A0A367LC84"/>
    <dbReference type="OrthoDB" id="4525710at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="80"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="129"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI12039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="532" mass="60102" checksum="B53A5283A3B50597" modified="2018-11-07" version="1" fragment="single">DEEKPRCRRCEQRHLPCSRPVRKTVFKHDSVASFAKDQKWFASILAALPPHVSRLQSTPSSPSPVATLLYRLSLFPPLPPPPPPPPPPPAPPPPPPPPPPPPPPSHEHVSNPSPAVQSIAYITSPPDPESSSPAPSSSSPTSYLCRHPSPPSQNGSSSRFPLHDVQEACLLRYFIEEMSHWFDLCDPHRHFQLVVPVRAGKHPHLLHAIFAVAARHLSRLPQYKTPQGILYHDQLLPNLNEHAAVEYMLKCIPALRQFHDMHDDDYRDSIITTAVILRQLEEIDQEDDSSAGPETKQVNFLAIIDAVLRSLPSLDVFAQRSLMQAAYWMALRQEIFNSFTRHEAPQLILPLEFWHSASKANKVVMHLVQTAKWHWGDGSESEWQRLSKQQNLIEQKVLIAFRPTYQRTADKTKGEIFPTIWYASNIDVTSVQLALIAKAVLVAENPYLKSPPTSRGNWRLVENEVRDLLLDLCGIALCNPASPPALVQAALGIGMYGDFFTDYYQRQAIRIVVERYRDAHAWPVQRLLDKFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCG1</accession>
    <name>A0A367LCG1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_0949</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCG1"/>
    <dbReference type="STRING" id="1330021.A0A367LCG1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF230">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI12104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="522" mass="59351" checksum="9B6D165094ECA735" modified="2018-11-07" version="1">METVNAVATALTIAAFILTPIYNLFLHPLRTFPGPLICRASSWPRHFHLVRGSLPLFTAALHKVYGPVVRVAPGELSFISPQAWRDIYLPLPDRQGARELKKDGRFYSIFGHCAGNIMTADFHHHELLRRQLSPGFSDRTLRLQEPIIQRYVDILVGKLRELSDKNPINLTDWFTYLTFDIISRMSLGSDLGCLDRSQFHPWVHAIKRNLREFVLLQLLAYFDLGWLNRRMTSSRVLNGRCRHEDLTRRMLQSRLEDDEEHFDIISVLQNLKEPFVRHGRLTRSAHDTYREVKSFEQLHSNMSLLILAGSETSATLMTGFFSLLAENAEARERVTREVRAAFSCEDEITLAAVKSLSYLLACIHETLRLLPPTPNAMPRLVGLGGHTIAGHHVPQHVRPSLLMRRRAVLMIRQTVVYVAPWAAGRSEENFTLPLEFHPERFLQDPTFAGDSLGAAQPFGIGHRSCLGRSLAYAETQLALAKMLYNFEVDVSPGSLGWTERQKAFVLWDKTEMTATVRPIGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCQ7</accession>
    <name>A0A367LCQ7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_0506</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCQ7"/>
    <dbReference type="STRING" id="1330021.A0A367LCQ7"/>
    <dbReference type="OrthoDB" id="3819888at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658:SF8">
        <property type="entry name" value="17-BETA-HYDROXYSTEROID DEHYDROGENASE 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="3">
        <location>
            <begin position="6"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI12206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="261" mass="27799" checksum="B9F5D5F7B3BB42E2" modified="2018-11-07" version="1">MKVDNRTFIISGGASGLGRACVERLARSGSTNVAILDTSNDAGEALAAKLGPSTRFFRCNVLHTSSVADAVREAARWAYETKRPLAGVVPAAGISVPATILDRAGSPFDLENFDLTVAVNLRGTIDLVRQTVEHMAKVEPNAEGERGVVVMVASSATFDGQRGQVAYAASKGAVASMTLPMARDLARYGIRCVAIAPSLFETGMTNLMPEKVRRHMHATMEFPNRGGRPDEFAQLVLHIIENPMLNGAVIRLDGAARPGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LD64</accession>
    <name>A0A367LD64_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_0771</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LD64"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI12172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="167" mass="18542" checksum="C290367A69E019A1" modified="2018-11-07" version="1">MVEMTTTFGILNTYRMCDAVSTANKIMSTYARREQQDKPGWPTRGGTVQGSMKPIKWAPSVSPLPVGLLFAIKIDRRGLISYCYPESRNSGDEPDDVLIASDGLPSTGWHRIPSSLRSDQINLAEKKLLCCRKTGGFIVSLFPDLFRALLISSFDYSADEPPSMLDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDD8</accession>
    <name>A0A367LDD8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1145</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDD8"/>
    <dbReference type="STRING" id="1330021.A0A367LDD8"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="512"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="660"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="717"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="784"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="845"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="865"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="890"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="902"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="937"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="965"/>
            <end position="985"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1021" mass="101150" checksum="AA5B3B52AABB4D42" modified="2018-11-07" version="1">MPMLIPQKIIDTRNSFFEKAAISWNLVNTTLKEADICSTTLNDNDVVDKLKASLHQGRADTTNVLYMTSNEDGSVPPGQSLVKGRCYVPDKSSKMPIEKLLGAIDGCSVAMDAALKEKTPVDAHECGHSLGEDHDQDPSHRDNLMAPSHDMNAVKDYDLDEGQIERMRHIALLRKSEATGQPYNGTVGDKVAKGWEERKKMRKPGGDIGGKPPTKIIPFPDPRQFGPMGEAPPGRSPDSPGPSASGPGGAPSGAGGDASSGAGGADGGSSGAGGGASSGADGGADGGSSGTGGGASSGADGGASSGAGGGLSGADGGSSGAGGGASSGADGGASGTRGGGSSGAGGAAPGAGGGPSGVGDTPSGAGGGPSGEGQGASRANNPSSEKGALEDNNGKKTLADKESKNKFFNKTARTTPATKSTGGFPTGFPTNFRTATRELSNVRSAFRSKKASPTSAPTGFETVTRELSGAFSGSGRLATTTARNQRARPTLTPSASSVPAGRKGPGLVPGSESGSQVSGGDRSQLTKEKKKKQEKLVDQSLNSKPGFRDEGEDPTEAGDAPRSKRKNRQANQNVDPRVGPPTDRKSTRLTSPAGSVSTSGPSIGRASPVPGTFSSSRGASRGGGQAGPGSSTRRQKSPVTGLGAQGPRATPVGGAGGGNKIAAAPSASRTTRRLSTPSPSPLGGSPGSRISPTRKQSTDSDPRLRSSRSGAVGNEIAAAPSASRTTRRLSTPSPSPLGGSPALRELPDDSLLPPLLLSGDLLSTDSDPRLRGSRSGTVGNEIAAAPSASRTTRRLSTPSPSPLGGSPGSKLSPTRKQSTDSDPGTGGSRPGGKKVATASSVSRTPPRPSPPSPSPPKGSPPGLSQTGRETQSGSRVRGSASAPIGGGSGNNIASGPSVSRTPPRPSPPSPSPPTGPPGPGLSQRQESRAGSGVQGKTTATTGSASGNTRDPGSRGDGSRMAARPQSPSRTPPFETSTGGTADARTSQPGGGPGNKGQKSGDAPTSGKSGGVNAVRRAVLAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDE7</accession>
    <name>A0A367LDE7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_1144</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDE7"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI12440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="87" mass="9696" checksum="1A87D186E2460A7E" modified="2018-11-07" version="1">MDIGSIKSGASGAPRRKRCYKCNQVGYFQPERTGGEAEIFDWGDRARTRPASVLCWENDPCNRATKRVLEVRLVDAARGPSKATPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDF0</accession>
    <name>A0A367LDF0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TeaA receptor TeaR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1147</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDF0"/>
    <dbReference type="STRING" id="1330021.A0A367LDF0"/>
    <dbReference type="OrthoDB" id="418495at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="365"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="444"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="495" mass="53249" checksum="37148711F185CFC9" modified="2018-11-07" version="1">MTTVVSPTATALTPPTSSEDEAPSWACPGAGQFESAQPLSDHDFDPAARKMHSAENLATSRRPSWSTGNQRPKAKSSERGPDDSQWIHRDKLARIESEELQAAGIFVPPSRLLAKQRRERSHSRLAPETGSHSKSSTESASPSEDLTVNNKPTEVAHQEGPNAYFVPAAGAKGGSRIPVAKLSPVPIPLDCLERGSQAVRRQVDGEGDGLAYQKPRSRSDSMSVGEAASGLPPATRRSVTDTSPKKNAPRKLSAASKASTVATRPKTRSGPGKDAARTFAKAGEPSGAGWAPEGDPPWMVNSYSPDPRLPPDQQLLPTVARRLQQEKWEKEGKFGDAYDKEFRPLNVHELSKPSTAAGAPRAGESSDDEDGDDNDETKEDAAQAPNAHPLSQHPADNLAPDEWPLRQGTGKGLNMRQGSYSTMPKITDSPSNAALSSPLGSAAQSPPQKQQQPQQQQQQQQQQQQQANNRVQKVPDLGGDDEKRKKFGCRCCIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDF8</accession>
    <name>A0A367LDF8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_0437</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDF8"/>
    <dbReference type="STRING" id="1330021.A0A367LDF8"/>
    <dbReference type="OrthoDB" id="267397at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14324">
        <property type="entry name" value="UBA_Dsk2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16106">
        <property type="entry name" value="Ubl_Dsk2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000024">
        <property type="entry name" value="Ubiquitin domain-containing protein DSK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015496">
        <property type="entry name" value="Ubiquilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677:SF3">
        <property type="entry name" value="FI07626P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677">
        <property type="entry name" value="UBIQUILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23195">
        <property type="entry name" value="UBQLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="45"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="398"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="316"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="341"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI12455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="444" mass="46201" checksum="CA92A279EE9695AD" modified="2018-11-07" version="1" fragment="single">LAFVLALPAPPSLVANASVFSPSPSGQPRRTASPMAETMADDAQITFKVKTSSDSTHTITMAESATVLELKTKLAGEDLENIPVERQRLIYSGRVMKNDDTLGSYKIKANNTIHMVKSAASNPAQPTTTAAAAPANMASGTANNPLAGLTGARYAGHQVNLPGMEMFGPDGGMGPPMDEERLHNMMSDPNTQQAIREALNNPDFINLMIESNPMLRNFPGARELMTSPGIQQMMSNPNMLRDAFRLQRMMGGEGAAFPAPGATDTTPDGGPTGNANQSIDPALISSLLGGGGGGGGGGDGNAMAQMLQTMMGGMGAAPSAPGGTGATPSAPRDGQTATPSQGGAEATQGQQTSNPFASLFPQQGGYPMGMNPEMMQQMMQMMSRGAQGAPAAPADNRPPEERYAEQLRQLNDMGFFDFDRNVAALRRSGGSVQGAIEHLLSATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDN7</accession>
    <name>A0A367LDN7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_0609</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDN7"/>
    <dbReference type="STRING" id="1330021.A0A367LDN7"/>
    <dbReference type="OrthoDB" id="7875889at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045182">
        <property type="term" value="F:translation regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00076">
        <property type="entry name" value="HFD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08049">
        <property type="entry name" value="TAF8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000039">
        <property type="entry name" value="Guanine nucleotide-binding protein subunit beta-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006565">
        <property type="entry name" value="BTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045223">
        <property type="entry name" value="RACK1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019473">
        <property type="entry name" value="TFIID_su8_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19868">
        <property type="entry name" value="RECEPTOR FOR ACTIVATED PROTEIN KINASE C RACK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07524">
        <property type="entry name" value="Bromo_TP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10406">
        <property type="entry name" value="TAF8_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Bromodomain associated" evidence="10">
        <location>
            <begin position="62"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor TFIID subunit 8 C-terminal" evidence="11">
        <location>
            <begin position="187"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="323"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="371"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="413"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="456"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="500"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="197"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="209"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI12526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="628" mass="70050" checksum="A0BFDE4B72CD9668" modified="2018-11-07" version="1">MASKRSLSPEQDSPEACSKRPRASSTLPAEVVPDVVDESIDELVDETERAFESLSLTHHHNARLGLQRSIALVLDHDGFSSATPEAVESFTNLVESYINSLVEETKRFALSSRRELPIPTDFGLTMRFHNLTTASLRPHLKHPLSRRRQLAPAYHSVAVADADALRTLPLLTEELSGQADKDAKCFIPASFPDFPSRHTYRYTPQEASSGRDPKKIREEAARTAQQGEDALRRLVRASKMRKQKEAKTLVERDSHGRERFRLWESTMRRFMGSGENPGQIEIADHSMIVNGDAIFARKDVSRMDHLCLEVPAMAEQLILKGTLESHTGWVTSLATSMENPNMLLSGSRDGELIIWNLTRDESTYGYPKRSLRGHSHIVSDCVISSDGAYALSASWDKTLRLWELATGQTTRRFVGHTNDVLSVSFSADNRQIVSGSRDRTIKLWNTLGDCKYTINDKGHSDWVSCVRFSPNPQNPVIVSSGWDKLVKVWELSTCKLQTDHIGHAGYINTVTISPDGSLCASGGKDGTTMLWDLNESKHLYSLNANDEIHALVFSPNRYWLCAATASSIIIFDLEKKTKVDELKPEFASVGKKSRDPECISLAWSADGQTLFAGYTDCLIRAWGVMSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDN8</accession>
    <name>A0A367LDN8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDN8"/>
    <dbReference type="OrthoDB" id="276515at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09083">
        <property type="entry name" value="EEP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF36">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="17"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="299" mass="33206" checksum="96E8F8D6C0A84D96" modified="2018-11-07" version="1">MTLTHRASDSMPLRLISFNIRYATDHPVGNEKPWKVRCPKLCNQLRFITSGRDSPFICLQEVLYSQLGDIQADLGCPWAHIGRGRDQGETDGEFSPIFYRADAWTCVRNETRWLSPTPRVPSRGWDAALNRIVTMGLFRHRVTGTRVVVMSTHFDHMGVVARANSAKLLIDFAREWSERPSVVLIGGDFNSPPDDEAYKVMTAPGSGMSDVASLVPESKRYGNEITYTSFGEGEVASRIDFLFIQEPRTATINTFGVLANSFDDKLLLSDHRPVVADIDVKLQGGDGLLGSPQSTEGRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-05-03" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDQ5</accession>
    <name>A0A367LDQ5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_0290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDQ5"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI12546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="127" mass="13505" checksum="D76AE50BB9BE0B65" modified="2018-11-07" version="1" fragment="single">MRGLAAGQWGGGVQLLYHYLEASIGITQLGLDRLSSASKFCMNISAASFDEDGSRPTNYLPNSLSAISIVNVLCGRAGRITTTTTITTTNSSSFFSSSFFSSSFFSSSFFSSSFFSSSPLSPFSLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LE32</accession>
    <name>A0A367LE32_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">asparagine synthase (glutamine-hydrolyzing)</fullName>
            <ecNumber evidence="2">6.3.5.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L249_1004</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-aspartate + L-glutamine + ATP + H2O = L-asparagine + L-glutamate + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12228"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-asparagine biosynthesis; L-asparagine from L-aspartate (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.4" evidence="2"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LE32"/>
    <dbReference type="STRING" id="1330021.A0A367LE32"/>
    <dbReference type="OrthoDB" id="409189at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00712">
        <property type="entry name" value="AsnB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000031">
        <property type="entry name" value="Asparagine synthase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000050">
        <property type="entry name" value="Asparagine synthetase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006426">
        <property type="entry name" value="Asn_synth_AEB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050795">
        <property type="entry name" value="Asn_Synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033738">
        <property type="entry name" value="AsnB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772">
        <property type="entry name" value="ASPARAGINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11772:SF2">
        <property type="entry name" value="ASPARAGINE SYNTHETASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001589">
        <property type="entry name" value="Asn_synthetase_glu-h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="6 10 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="5 10 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="14">
        <location>
            <begin position="2"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="11">
        <location>
            <position position="2"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="375"/>
            <end position="376"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for beta-aspartyl-AMP intermediate formation" evidence="13">
        <location>
            <position position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR001589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001589-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCI12683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="579" mass="65478" checksum="4F1F3F5E0E025434" modified="2018-11-07" version="1">MCGIFACHRHPDVHKFKPTALRLAKQIRHRGPDWSGSIISKQTILCHERLCIVGVESGAQPLTNADESLVLAVNGEIYNHRMIRRHLKEVYHFKTHSDCEVIIPLYMEYDLNAPCHLDGMFSFVLYDKTQDRIVAARDPIGITTFYQGWSSKEPDTVYFASELKSLYPVCDKVVAFPPGHVFDSKTGQTTRYFKPSWWDPANVPSDPVDYKALRHALEKAVKKRLMAEVPYGVLLSGGLDSSLVASIAQRETLRLKTKAIAINGNDEVHGNPDLGEGLVGIDDEDNLDTVTYLPQLNSFSIGLPGSPDNKAALEVAKFLGTKHHVMTFTIEDGLNALSDVIYHLETYDVTTIRASTPMYLLSRKIKAMGIKMVLSGEGSDEIFGGYLYFHAAPDSKAFHEETVRRVKNLHLADCLRANKSTSAWGLEARVPFLDKEFLELSMNIDPREKMITKDRIEKYIIRKAFDTSDEPDTAPYLPESILWRQKEQFSDGVGYGWIDALKDNAELHVTDEMMKKPKPEWGDDVPDTKEAYWYRLMFDEHFPPHCASTVMRWTPTWCRQTDPSGRAISTHVAKYDGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LE42</accession>
    <name>A0A367LE42_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Beta-lactamase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LE42"/>
    <dbReference type="STRING" id="1330021.A0A367LE42"/>
    <dbReference type="OrthoDB" id="5946976at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052907">
        <property type="entry name" value="Beta-lactamase/esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43319">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43319:SF3">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="1">
        <location>
            <begin position="15"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="378" mass="41229" checksum="636ED17406861AB1" modified="2018-11-07" version="1">MAKVSGTCDPRFDQVRRLLADKVESGEELGASIAVNIDGKLVVDIWAGYADENRSRPWERDTIVNVWSSTKTVISLAVLILVDQGRLDVDDKVSKHWPEFGCNGKEDILVRHLLSHSAGLSGFQDQTSMEDLYDFDLCVARLASQPPWWTPGTASGYESVTMGYLLGELVRRVSGKGFREFVADEVAAPLKADFQIGAAEKDWQRVADVVPSKVPLDFTQLEPDGIAMRTFDNPRLSPGSANTASWRKADLGASNGHGNARSLVRMLSAVTLGGEVDGIRLLSEKTIDLIGREQTNGTDLVLQLPIRWGIGFALTPSGVHTFLPEGRVHFWGGWGGSFIAVDLDRRMTISYVMNKMGDGVGGNDRGAAYGEAIYRAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LE90</accession>
    <name>A0A367LE90_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1274</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LE90"/>
    <dbReference type="STRING" id="1330021.A0A367LE90"/>
    <dbReference type="OrthoDB" id="1844152at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="146" mass="16506" checksum="4CEB44232107313A" modified="2018-11-07" version="1" fragment="single">MPCYLDRFGGVLSAAAYTIRLMPNIPSKCYSFSSGFSYVQAALPFLLFFFFSLSWLVALACPCRAPEEDGVPVYGYRSLLEPTFVLRARFAFGARSLIRAGRSHIKDRPFLLRRWCPDVMVLPIKYLEELRLKPGSQLSLVEAQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEJ8</accession>
    <name>A0A367LEJ8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prefoldin subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_0165</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEJ8"/>
    <dbReference type="STRING" id="1330021.A0A367LEJ8"/>
    <dbReference type="OrthoDB" id="248120at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23161">
        <property type="entry name" value="Prefoldin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000003">
        <property type="entry name" value="Prefoldin subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="79"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI12840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="119" mass="13562" checksum="BCDE121B0B46A96C" modified="2018-11-07" version="1">MAETQARLQSLSDEYQQLQQDLQKRVSSRQKLEAQKQENLGVKKEFEELGEGETIYKLVGPVLLKQDKVEAESTVKGRLDFIGSEISRLEVEVKETQEKLEKKKVEIIQTQASVQGRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LF54</accession>
    <name>A0A367LF54_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">mRNA 3'-end-processing protein RNA14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_0077</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 4">Component of the cleavage factor IA (CFIA) complex, which is involved in the endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="4">Nucleus and/or cytoplasm.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LF54"/>
    <dbReference type="STRING" id="1330021.A0A367LF54"/>
    <dbReference type="OrthoDB" id="26282at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0180010">
        <property type="term" value="P:co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045243">
        <property type="entry name" value="Rna14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008847">
        <property type="entry name" value="Suf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980:SF0">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980">
        <property type="entry name" value="RNA CLEAVAGE STIMULATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05843">
        <property type="entry name" value="Suf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Suppressor of forked" evidence="6">
        <location>
            <begin position="164"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="558"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="796"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="95"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="565"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="588"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU369035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI13047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1017" mass="113229" checksum="D621575ADA71D7EC" modified="2018-11-07" version="1">MAAASAAGDVTWNGDEDPVTNDSHQPQPTKDQPYGLRNNTTVGDEDDADDGADYDPESVALDATPQVLEPTATPTSLPAPPSSKPKTSGGFLVEVSDDDDEDDDEDDDDDDDDDEDDADDDNDAPSAGAPQMQTKAAAATSGLSPAPQADASSAAPQIVPKLDTVTLLESRIKDDPRGDMDAWLSLMAEHKRRNRLQELRNVYRRFLDVFPQAADIWVEWIEMELDLDNFVDAERLFGLSLVTVLNVKLWTLYLNYIRRRNDLTNDPAGSARRTVAQSYDFVIDNIGVDRDSGNIWQDYIAFIKSAPGQVGGTGWQDQQKMDQLRKAYQRAINVPMLTVNTMWREYDQFEMGLNKVTGRKFIQEKSPGYMSAKSANIALDNMARSLKRNNLPRLPPAPGFEGHEEFRVQVELWKKWVAWEKDDPLVLKDDEPQAYKQRVVYCYKQALMTLRFWPEMWVDAATWCLDNDVRDAENKSVGTELLLQGIAANPESVLLAFTHADHVEAHYPEKEGDKLEYAKAVRQPYDTVLETLYKMGDKIKEREKLEVSAVKAAATLYPSMQESIEPVDDDDDDDDDDDDDDDAEERERRKKKKKARKSPTEERIAAIQSAHAAESQLLSRTLSYVWIALARAMRRIQGKGSQSEGGLRKVFTDARQKGRLTSDVYVAVALLESVVYKDAVGSKIFERGARLFPNDENFMIEYIRFLHSKDDTTNARVVFETCANRLVSRPETRDKARPLYAYFHKYESQYGELSQISKLEHRMAELFPDDAKLSYFKSRHSSDRFDPVAAPIIVSKAVQMRPKQRMEQAASGRNSMAPPRRELSPPRPQYGRATASPKRPYGADDEEANPPKRLARGVSPLKGAAGRRLDQQRRNQASALHRDITFLLGILPPSHSYDAPRLHAASMVSLLRDTPLPDYSTWRAKTGGHYRAPVAMHGRQTSGDLGGGGGGGGGGGVGRPLSPYGGGRLASAGGYRSSPLRAESEAGAAFAANAYVGAEVNNAAVWPGQQYGGYRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LG05</accession>
    <name>A0A367LG05_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-rRNA-processing protein IPI3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_0865</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the WD repeat IPI3/WDR18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LG05"/>
    <dbReference type="STRING" id="1330021.A0A367LG05"/>
    <dbReference type="OrthoDB" id="756370at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000929">
        <property type="entry name" value="Ribosomal assembly complex component Ipi3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045227">
        <property type="entry name" value="WDR18/Ipi3/RID3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763">
        <property type="entry name" value="WD-REPEAT PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 5 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="171"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI13355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="429" mass="46138" checksum="127467FA2417EC14" modified="2018-11-07" version="1">MASDLLFSSIRGPPIAANTSVARDVAIRGHTISPSWTAEATFRKSSTAPHCLAVSSAHVFAAQDSKAQVHVYSRARRNQEALVSFQERIRCLALAGDVLVMGTIEGRLILWETRTGRQVATPPCHVRAVSCLAASPLHLLSASDDSNINVWSLARLLELGADVGHEPDLVLSNHRAPITDIALGPSTSAETSICVSASKDKTCILWNYRSGQLLRTLLFPAAPLCIAFDPCARALFASADDGGLYLVELFADQPRSDRPAVVQADAPLGVVNSDIGPVSCLTVSHDGTLIYTGHEKGSIMRWSLADNGHPTEVDNLNAAVTNLVFAPMNRENKTLTSVEVVKPSPTQRKYVLTAQLEGHVKSGPTFSDKLRCTGLDPGLLESAMVSFEAAGSTESDESGLRKEVEELRSIVEEQKALQQATMRYKTTDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGN1</accession>
    <name>A0A367LGN1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5623</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGN1"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI13575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="84" mass="9818" checksum="5B1B8B8364B6D742" modified="2018-11-07" version="1" fragment="single">DEEDRIGFLFRSLKGKARKTLKTRLLTKTKDNSLSYEDFYGYIKDSVYYRKRDAPNDLPAFAKYSLSILLPKTPLLNRQIDLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LH60</accession>
    <name>A0A367LH60_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA ligase</fullName>
            <ecNumber evidence="14">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">L249_7983</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="14"/>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LH60"/>
    <dbReference type="STRING" id="1330021.A0A367LH60"/>
    <dbReference type="OrthoDB" id="206088at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903461">
        <property type="term" value="P:Okazaki fragment processing involved in mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07900">
        <property type="entry name" value="Adenylation_DNA_ligase_I_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07969">
        <property type="entry name" value="OBF_DNA_ligase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3260.10:FF:000001">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000062">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000016">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF4">
        <property type="entry name" value="DNA LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00333">
        <property type="entry name" value="DNA_LIGASE_A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="17">
        <location>
            <begin position="662"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="102"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="903"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RCI13776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="939" mass="104770" checksum="39DB2F8FD15582F4" modified="2018-11-07" version="1">MPPAIRDYRFPASPLIDLLLCCASRCAVVDRSCFLTSLSAEQRRFSHPLPTAHTTERGPRQLTSRRGIIMAPKQATLGYVKPEQSTLRKFFGAKGEAPLRQAKLGFATTEEKKKKKKKKNDDDAEMSVETESKKRSADGNLDDDDRSPVAKRQRRTRVKTEDDEDEASEKKRTPDEKPEDEDGSLVANRRRRTRAKVEDDEDEVSEKSVERSPKRAKEVSKEIKEEDAEEESLAESDSEAEVDEEQPEAAAKAREKAQAQLKFKGQQHPYPDWTAGAPVPYAALCQTFSLIELTTKRLVIMGHCSLFLRQVMRLTPDDLLPTVLLMVNKLAPDYAGIELGIGESLIMKAIGETTGRSIQVIKADQKEIGDLGLVAVKSRSTQPTMFKQKPLTVRAVHQGLMTIATVTGSGAQGRKVDNIKKLLSAADASASGKIDITKDRGGPSEAKFIIRFLEGKLRLGLAERTVLVSLAQAAVCREAEEEGRVPSTAELEKGESMLKTVYSELPSYDVVVPALLKHGIEKLRDECKLRPGVPLKPMLAKPTKAITEVLDRFEGQTFTCEYKYDGERAQIHYVARDAPQHLDEAADGANVKAAGGVACIFSRNSEDLSKKYPDILAKLHSWVGKETMSFVLDCETVAWDVEERKVLPFQQLMTRKRKDVKVEDVKVKVCVFAFDLLYLNGRAVVEKSLRERRELLRQAFTPVEGEFAFASCMNGQELDEIQGFLEESVKASCEGLMVKMLDGKESGYEPSKRSRNWLKIKKDYLTGMGDSLDLVVIGAYHGRGKRTSVYGAFLLACYNQTTETYETICNIGTGFSETELESLHEKLSSITIDRPKPYYSHASSAQHQPDVWFEDRFVWEVKAADLTLSPRYKAASSGPVDASLPAGRGISLRFPRFVRLREDKKPRDATSSRQVTELYRKQESVAGGKAPAVDDDFEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LH96</accession>
    <name>A0A367LH96_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LH96"/>
    <dbReference type="OrthoDB" id="10628613at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="256" mass="26177" checksum="171E4655E8C21AA3" modified="2018-11-07" version="1">MTVHLLWSSPYICNIHTHPPLVISLSPFLIPPRPTITNHIDIMVRPRPLYLSLLATAATVTAADEKAANQTNATDSDVPTLSQLGCLASLLPPALPLPTMPAELESLIRSDGSCVPSSLSSDAENLRSQMIHYSTYVQAHTKTCSIPASLSADFDFLSTLDFSKNEVTVCPSGDEKATTVKTSSSSAASASATSVTSSPSASQKGSGKPTNSSSTASKTSGSAAASNTSDKSSNAAALKAGFAVAAAAAGLAVLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHI8</accession>
    <name>A0A367LHI8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anaphase-promoting complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_7962</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHI8"/>
    <dbReference type="STRING" id="1330021.A0A367LHI8"/>
    <dbReference type="OrthoDB" id="2110451at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024789">
        <property type="entry name" value="APC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024790">
        <property type="entry name" value="APC4_long_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13260">
        <property type="entry name" value="ANAPHASE PROMOTING COMPLEX SUBUNIT 4 APC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13260:SF0">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12896">
        <property type="entry name" value="ANAPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="6">
        <location>
            <begin position="27"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 4 long" evidence="7">
        <location>
            <begin position="273"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI13888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="762" mass="84145" checksum="D58BC1DCE2A67B15" modified="2018-11-07" version="1">MAQVKQLVLLSETELNSRAPRGFPVGCPTLDVASSWDSNSKSLFVYRPPGQVISKMHLLRAHGEAALEAVAVTWSPDGQFLAVGWSDGVVRLMRLENNKVAHRIPVCQGTDAQITYIGWTGSNLPKKTSAGILPGGTLASDAAVEADGLPADLPQALTFLEIDSALPKLSPLPSGSAGSDEDANVFTLRAGVDLLFQPPNQEDHDTVNVLVVGSSDGSVQLNIHDSFVVGTFQHPVLGTSSASRLIHHASHPDVSTHALVLADDATEPREIQLLPMDLPFISSSPINLSLLASKLTTLQKLLRYLKEAQLHMQVEWRNARELPARFLRAIRGDLEGMQRGPRSIVPALYHVVVTGHCHEPVREWLADTLAERGHKRWEKAVVSGLENLRSLVHENFLPALERCALIFSRLRGLAQFHDDRDDIGFSVSQIKRVLDIIGCLHLVGHKVLAHVMDELEHFAVFSAWLRFQIEILAAGAGRSEELTEKEATMDTSKVLTYIEKYLTESPLDMFFDDISTKDCAADWNYCEDGPSLLQMLDSQLKKREEGQPSMRALPHVHFLVNYMTNWCGRIFQSVAESMKRSVRFGKPITLSMGAPITKMDVRVSKDGEGAFIYTALACKDRENKVYILRVEMDIVNGISRNLPAMGCCVDLATCQLIDAKFLNDKTLVVLCKQQDLPPSIMLIPVQSGKLPFAPWDDGRLKDVGIVPTDGFVKQAIPGQQSTRCVRMELHDRSEAKGDIPERICFLSSNHTTWRTFSTGATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHM7</accession>
    <name>A0A367LHM7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RSE1/DDB1/CPSF1 first beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LHM7"/>
    <dbReference type="OrthoDB" id="20774at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="1">
        <location>
            <begin position="59"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1311" mass="145139" checksum="E1ECF77BDE886A84" modified="2018-11-07" version="1">MAFQTSVLRNGEWVTETVNVQSALRQASAAASAGPVLEQPPELPPYGLLSRTIVQSPIVHRVLPVRLRSKLRNDIAFIGTDQGADVSSQDWFVQISELRRDGQVHQVARKKNFGSRIRSAAVLGHSLEHGLDEEAPTGFFKFDDDGSVIMADAPDHPQLPPQLLVLMLESGKAVFLFLRDQPGSPIDFVTATFALNRAIPYMGYHLAVDPSSRYMAAASPEGVVAIFELEDTRALNAQFVASGHVSPVKSVKVRLLQGVLHKLEFLHPHPEDDNHIILILIHIRKERRSRDPVTRMVIYEWMVGDSLKEVFDGDRCGTRLPQEHRLPLLLIPLRFNTAFFTVSEKSIGIVRDCLSGPPVFESLGADPPSQTALHHGVRPPLWTAWARPFRRQKYFERTDIIYLAREDGAIIHIEIETGDLVPFITNVGCLDANINTAFTAAYDVYSDILLIGGDSGPGGIWKLAPRSELEQVSILPNWSPVIDAAVVTWSKPVEGAVRPKPDAVFTASGRGSKGTLTQWRWGFQGRIGLEIESDDPVRHSWAFDLYARGEDGGLCVLLAFSDSTALLRFSDDFGDADAATAQDTDLDLSSRTLDAFWSQQGTIIQVTERFVTLCTSLKSGAGSRYSLDELLGTDNVVALNASCLDDTIAISSHTERASRLHTLLVTPTGLRNCHWWEARGDLTCILLFWAAGSKYVIAGSMVEGKAWVLLYTLAGENLAADAVSSLHGESVLFPHQSVNGIQTFGQFEALTSICHVCDSAGEVHLVAGTNSGALLTVKISPKEGKPMSILAEAMGAGPVEVFSTWGSFQGTAAALVCCDNALVVMNDFCPRTRRFRAKQHVWLTDASDESMPSPAIHSVCSLRRDISGSPGHLSLMVQAKSKLLLAEIWPDVGLVPRSIRLEGSPMRVIYSDTWECLVVALLKDDKPTLAFIDPATGEAKATPADRERRDAEFITGLGHAGDRIYCLHEWNYVKDGKTFTFILVATKDGRLLMVSVGARAAGGLQYSTRYKRMLGRPIYSVVGDDQGILFCVDRTVRWEVLDLAEKRLRPMGEFRLDSPATSLSVAGKDGCLFALTTQHSVEVIDYRGKNMTLVHSDPVSRSTVHTIHGHSGMGLLSDQTGGIAVIRQPWSRRSREFEIVLETRLPTSVRRFVRAQSRPLWLSARRSLYVERPEEEVLAVHASGEILGLSLDGSLHHFFLLDMNLWRFLRLVDQLARARPEDVVEEPEPHPLQLHVDGDLLERCVVQRPGSLEEMLCTADRFYLFCRCLDLIRRGHYTRWPGKEEMPEWTRRELYVALGHDIVAHYLDPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHS1</accession>
    <name>A0A367LHS1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="13">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">L249_8300</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:21249"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="13"/>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHS1"/>
    <dbReference type="STRING" id="1330021.A0A367LHS1"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.150:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1070.20:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000008">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000007">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009674">
        <property type="entry name" value="Rpa2_dom_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06883">
        <property type="entry name" value="RNA_pol_Rpa2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="17">
        <location>
            <begin position="40"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="16">
        <location>
            <begin position="203"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="18">
        <location>
            <begin position="490"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase I subunit RPA2" evidence="19">
        <location>
            <begin position="594"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="14">
        <location>
            <begin position="701"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="15">
        <location>
            <begin position="1080"/>
            <end position="1125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF06883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RCI13975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1231" mass="137439" checksum="9DFA5789B522B7FE" modified="2018-11-07" version="1">MPSPPTETHWDHTYNTLRRQKLFQHPPTDHSAYPALQAAVDPHIRSFNCLFPSDGSPGLLAHAITDIGSKIYLDGDANIPLRERNELRIRIKDVTLQKPLLPPSNKSARTREILPSECRQRHATYRGRLSVTFEYEINNNGAVEFVRELGQFPIMVKSNRCHLENNSPALLVQRKEESEEMGGYFIVNGIEKLIRLLQVNKRNFPMAIQRPAFAKRGTGYTHHGIVIRSVRPDETPQTNALHYLKDGNITFRFSWRKNEYLVPVMMILKALVDTNDREIYEGIIGPIGCSSHENTLLADRVEVMLRTYKTYGLRGKSATRAFLGDKFRVVLGISDTMTDRDAGNEFLRKVVLVHLGNVDVTDSQDDDKFRLLLFMVRKLYALADGACAVDNADVVQNQELLIGGFMYSQILKERLDDFLGVAVRSSLRDFFRKKPDVRFTSDEFRKNFPSRIFAKANENLGGGMEYFLSTGNLQSPSGLDLQQTSGFTIMAERLNFLRFISHFRMVHRGAFFAQLKTTGVRKLVPESWGFLCPVHTPDGTPCGLLNHLAHKCQIMTDSLDVSALPELATELGIVATSSASTKESVVVMLDGKVLGWCSPIECRRIAHCFRHWKVEGTHGVPLQLEIGYVPPSNGGTYPGIFMSSQRTRMVRPVKYLPLLAEDFVGSFEQPYMSIAVVPHEIESGESTHVEYAPTNILSILANMTPFSDFNQSPRNMYQCQMGKQTMGTPATALPARSDHKLYMLQTGQTPVVRPPLHNTYGFDNFPNGTNAVVAVISYTGYDMDDAMIINKSADERGFGYGTIYKTHMITLKEGTRNTARKSMTKAFGFAPHSFVSAEHQGMLDDDGLPHVGRMLTRGDVICAYHEVTTDYNGKLINLDGVTQFKRYKEEETCFVEAVQLLGAETGSEPLQTVSIKLRIPRGPVVGDKFSSRHGQKGVCSQKWPMVDMPFSESGIQPDIIINPHAFPSRMTIGMFVESLAGKAGALHGLAQDSTPFQFDEADNTAGDYFGQQLIKAGFNFYGNEPMYSGITGEELGADIFIGVVYYQRLRHMVNDKYQVRTTGPVVPTTLQPVQGRQRGGGIRVGEMERDALLAHGTAFLLQDRLLNCSDYCPSWICRRCGSFLSVQPAVSRFTPTSGRRAQPTVVRCRSCAVRLDDGIDLTQVQGEVWEDGHGVSWVGGDDTTMVVVPGALRYLDVELAAMGVKLKYNVSDKDKPRKGPLRRLAKVSGRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LI90</accession>
    <name>A0A367LI90_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WH1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_8259</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI14097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LI90"/>
    <dbReference type="STRING" id="1330021.A0A367LI90"/>
    <dbReference type="OrthoDB" id="8963340at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045010">
        <property type="term" value="P:actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01205">
        <property type="entry name" value="EVH1_WASP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000281">
        <property type="entry name" value="Actin associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033927">
        <property type="entry name" value="WASPfam_EVH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000697">
        <property type="entry name" value="WH1/EVH1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00568">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02205">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00461">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50229">
        <property type="entry name" value="WH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH1" evidence="3">
        <location>
            <begin position="17"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="WH2" evidence="4">
        <location>
            <begin position="598"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="237"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="281"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="355"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="387"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="420"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="616"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="631"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI14097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="683" mass="70266" checksum="67ED33089E59719E" modified="2018-11-07" version="1">MPSILNEDDRDTVKRVVPKQYNKIQAVAVARLYVAYPNPSKWTYTGLQGAVVLANDLVGNTYWLKMVDVSPAGRGVIWDQEIFDSWTYNQDRTFFHTFELEDCLAGLSFVDEKEAKQFKKKMDDRERNANRATRATPFGGGGYHHPAPKHSGLLGGLFHRHTSGSSHAQPNNLTSPSTVTLNGGPPPSEFAMLDAFDPLWREHFGEDLANKGLNDDFIRENQEFIIDFLREEQEKIQAQFAPRPSPAAASHPPPPPPPAPTNGGETKTTRTVPPPPPRPAGAPAGSTPSPIARRAVPPPPPAPRRSAKSDSPLREVTPPRELSAPRPKFNAPPPLPDAGKFSHQNGLKPTAAANPGPPPPPRPAKTPSEIEMPSQKPGGLLPLNTGAARIPRSPSARVPVPPPPPPRASDASPSQSAGVPAPPPLPPKLPTAGAPTPPPPPPLPPASSRPVPSAPSAPPPPPSAPATSAPPPPPLPASSAPPPPPLPSSNAPPPPPLPSSNAPPPPPLPSSSAPPPPPLPTSSAPPPPPLPSSDAPPPPPPPAPAPEAAAPPPPPPPPPPGSGAPPPPPPPPPPPAMPPSRDSGYASGVPAMPAADSGRSAMLGDIQKAGGIGSLKKVDRSQIRDRSSAQTGGGGGGGGGAAPTGAPPGAGGGGGMADALAAALQKRKEKVSKSDDEDDDDDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIE8</accession>
    <name>A0A367LIE8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_6037</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIE8"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="83" mass="9161" checksum="1A0F9460D0FCDAE5" modified="2018-11-07" version="1" fragment="single">LVPRSLIKWFKRSGSLLGSRLPVLATEGRGLSLGSCCTMNKDSKIKRKEEKGGIKLCALRKTIYTATRDPGSVRAMIKWLVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIQ2</accession>
    <name>A0A367LIQ2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Histone-lysine N-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_5934</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIQ2"/>
    <dbReference type="STRING" id="1330021.A0A367LIQ2"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19473">
        <property type="entry name" value="SET_SUV39H_DIM5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050973">
        <property type="entry name" value="H3K9_Histone-Lys_N-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007728">
        <property type="entry name" value="Pre-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223:SF3">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SET-23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46223">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SUV39H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05033">
        <property type="entry name" value="Pre-SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00468">
        <property type="entry name" value="PreSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50867">
        <property type="entry name" value="PRE_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Pre-SET" evidence="9">
        <location>
            <begin position="79"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="8">
        <location>
            <begin position="156"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="10">
        <location>
            <begin position="307"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI14304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="36175" checksum="5FD5E527872BC777" modified="2018-11-07" version="1">MTVMEEATKRHFFYHGKGEFAHEQDDCQWCQLRSFSTHQTAPISVVNTVDSQVLPPGFRFIDENVLGDGVEPAELSFRSGCTCDDDDDCQYAGCMCLAELEDDDSGKIYPYHTHGVKAGLLRSRLHSSKLPLYECHQGCSCTLACPNRVVERGRTIPLQIFRTENRGWGVRTLEVIKCGQFVDRYVGEVITSAEADRRRSAAAFSQSKDVYLFALDKFTDTASLDTRLRGPPLEVDGEFMSGPTRFINHSCEPNLRIFARVGDHADKHLHDLAFFAIKDISKGEELTFDYVDGGSLEAEELDGAVEEMTPCLCGSARCRGFLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIR8</accession>
    <name>A0A367LIR8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Isoleucine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L249_5945</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Ile) + L-isoleucine + ATP = L-isoleucyl-tRNA(Ile) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIR8"/>
    <dbReference type="STRING" id="1330021.A0A367LIR8"/>
    <dbReference type="OrthoDB" id="1706657at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07961">
        <property type="entry name" value="Anticodon_Ia_Ile_ABEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00818">
        <property type="entry name" value="IleRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000044">
        <property type="entry name" value="Isoleucine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000004">
        <property type="entry name" value="Isoleucyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000023">
        <property type="entry name" value="Isoleucyl-tRNA synthetase,cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000050">
        <property type="entry name" value="Isoleucyl-tRNA synthetase,cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033709">
        <property type="entry name" value="Anticodon_Ile_ABEc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19302">
        <property type="entry name" value="DUF5915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="14">
        <location>
            <begin position="10"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="15">
        <location>
            <begin position="689"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00069879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCI14333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1073" mass="123699" checksum="80A340A34543DB08" modified="2018-11-07" version="1">MDFPNEELATLQRWQKIDAFHRQLELSAGRPHYTFYDGPPFATGLPHYGHLLASTIKDTITRYWSMKGFHVERRFGWDTHGVPIEYEIDKKLGISGKAAVTEFGIEKYNAECRSIVMRFSEEWRKTIERLGRWIDFDNDYKTMDPSFMESEWWVFKQLFDKGQVYQGYRVMPYSTALTTALSNFEANQNYQDVIDPAVVVSFPLLDDPAVHLVAWTTTPWTLPSHTGLAVNPDFEYVKIHDEKSGKTFILLEKLLNTLYKDPKKAKFTVVGKIRGKDMLGWRYKPPFDYFYDEFKDFGFRVLGGAYVTDDSGTGVVHQAPAFGEDDYNVALEAGVITERRPPPDPVNDTGHFTDRAPDFVGMHVKDADKHIIKHLKNCDRLVVESQIRHSYPMCPRSDKPLIYRAVPSWFIRIPHIIPDMLKNIEVTHWVPSFVKERRFASWIANARDWNVSRNRYWGTPIPLWVSDDLVERVCVGSVAELRELSGYDGDLTDIHRDKIDHITIPSRTGKGVLRRVEEVFDCWFESGSMPYASQHYPFENVDKFKKTFPGDFIAEGLDQTRGWFYTLLVLGTHLFGCSPFQNCVVNGIVLAEDGKKMSKRLKNYPDPVLVMEKYGSDALRLYLINSPVVRAEPFRFKESGVKEVVQKVLLPLWNSFKFFEGQSALLRKVEGVDYIWRPDRQSPNSNVMDRWILASCQSLLQFVNEEMREYRLYTVVPRLLGLIDNTTNWYIRFNRRRLKGENGKEDTMCALDALFEVLYTLCRGLAPFAPFLTDSIYLKLLAHIPKEFQEEDPRSVHFLLFPEVRQGLFDVDVERRVGRMQRVIELARVSRERRGIGLKTPLKSLVVIHHDQQYLDDIATLQNYITEELNLRDLVTSRDEAKYSVQFSVTADWPVLGKKLRKDMARVKKALPGLSSDQVQGYLEDGEILVDGIRLVAGDLVIRRGLAEDATSNNLEMNSDNEVLTILDVEICPELAQEGVAREFINRVQRLRKKAGLQATDDIRMAYRVLSDPDNTGIAAVLSSHAATFERALRRPLEKFEDASKDGSKDDKVIIEEEQEVQRATFLLRLLHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIZ8</accession>
    <name>A0A367LIZ8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5958</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIZ8"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="37" mass="4277" checksum="97763325944A13AE" modified="2018-11-07" version="1" fragment="single">AQRLQRGRVRTYRGHSGRVIAIDRIDTYKSSSKSPIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJ05</accession>
    <name>A0A367LJ05_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alkyl transferase</fullName>
            <ecNumber evidence="3">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_6181</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJ05"/>
    <dbReference type="STRING" id="1330021.A0A367LJ05"/>
    <dbReference type="OrthoDB" id="4173905at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904423">
        <property type="term" value="C:dehydrodolichyl diphosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045547">
        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016094">
        <property type="term" value="P:polyprenol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291:SF43">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT DHDDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="208"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="238"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI14423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="389" mass="43678" checksum="26C825CCBD23BC1E" modified="2018-11-07" version="1">MAANSVSLLRRFIVESPPGEWALNQLRNLLIGALRQGNIPQHVAFEMDGNRRYARSHRMETLEGHHRGFEALARIMEICYRCGVKVVTVYAFSVENYNRPKHEVEGLMQLAKVKLEQLTTYGDILDRYGASVRILGQRDMIRHDVLAVVDKAVARTRHNSRTVLNICFPYTSRAEITTAIRSTVDNFLAPSPRKNTPFSPSRIRQKVLSTQLGHDSTTNDDTSTSEFETDADADADGGDSSTSTTTTTTTTTTSTATSTATSTATTSPLLLLLRDSPLQKANHPNPNPLPNPESITVETLDKHMYTALDPPLDLFVRTSGVERLSDFMLWQCHQETHIFFLTCYWPDLDLQHFIWVLLEWQWRRRQKERDVAAAAAAAAAAMTPRPPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJ24</accession>
    <name>A0A367LJ24_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_6024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJ24"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="73" mass="8468" checksum="06F76692225439C4" modified="2018-11-07" version="1" fragment="single">DKEDRIGFLFYSLEGKARKILETRLLTKTKDNSLSYKDFCGYIKDSAIKRLNAKLVLLAEKKLLLDYAARKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJ51</accession>
    <name>A0A367LJ51_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetylgalactosaminide beta-1,3-galactosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.122</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_6166</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.122" evidence="4"/>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJ51"/>
    <dbReference type="STRING" id="1330021.A0A367LJ51"/>
    <dbReference type="OrthoDB" id="414175at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016263">
        <property type="term" value="F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF40">
        <property type="entry name" value="APPLE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="13">
        <location>
            <begin position="213"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="53"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI14430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="516" mass="58487" checksum="E026AF58BA34C603" modified="2018-11-07" version="1">MRAVMEKKPSSLGGHILPRHLLPPRRVIIIATLFVAGLFLTCLRLAAARCDESHGGGQRRYCGFRSSSSSSSSSSSSSRHNDDAFPAAAVFSEKNEQERQQECAAFPDTSRVLLVMKTGASEAYARLPTQILTSLQCVSDYLFYSDMQQSVAGHLVRDSLDTVLASVRLTNKDFDIYHRQRACDADQAACNKGYDVGQEAWNLDKYKNIHMAEKTYAQKPDYDWYMFVDADTYVAWPTLMPWLDQLDAEKKHYLGSVAYVANFPFGHGGSGYLVSQAAMRHMFRGRSGVANRWDEYITGQCCGDFAFSYALNNETGVGVEQSWPTLNGEKPYTLPYGARAWCQPIVTMHHVNPEEVAEIWSLEVASNFSHPMRIRDLYHAFIERKLRPVRNDWDNLSETTSYLNASAYHYSESEVKQAKKGELSALERMAHLSFEDCRRACQSVASCVQYHFRNGICSFSDTVRHGKPTKPEKPEHEAQWQHRSGWMVKRIENWVRAHDDCGQEVTYPVKDGGWLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJZ7</accession>
    <name>A0A367LJZ7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Vacuolar transporter chaperone complex subunit 4</fullName>
            <ecNumber evidence="3">2.7.4.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Polyphosphate kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">SPX-dependent polyphosphate polymerase VTC subunit 4</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Vacuolar membrane polyphosphate polymerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">L249_6810</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>[phosphate](n) + ATP = [phosphate](n+1) + ADP</text>
            <dbReference type="Rhea" id="RHEA:19573"/>
            <dbReference type="Rhea" id="RHEA-COMP:9859"/>
            <dbReference type="Rhea" id="RHEA-COMP:14280"/>
            <dbReference type="ChEBI" id="CHEBI:16838"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19574"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Vacuole membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the VTC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.1" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJZ7"/>
    <dbReference type="STRING" id="1330021.A0A367LJZ7"/>
    <dbReference type="OrthoDB" id="6493944at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033254">
        <property type="term" value="C:vacuolar transporter chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008976">
        <property type="term" value="F:polyphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016237">
        <property type="term" value="P:microautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07751">
        <property type="entry name" value="PolyPPase_VTC4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14480">
        <property type="entry name" value="SPX_VTC2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.100.30:FF:000001">
        <property type="entry name" value="Vacuolar transporter chaperone 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="entry name" value="VTC, catalytic tunnel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="702"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="744"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="17">
        <location>
            <begin position="1"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="501"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="517"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="531"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00050204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00075894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RCI14582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="771" mass="87649" checksum="292DAB61DA658B41" modified="2018-11-07" version="1">MKFGEQLRSSVIREYQWYYIDYNGLKAELKNATGPFKTGGREWTEEDETRFVGKLEDELEKVHTKQQVKAMEISRRIAVSDREVRDVVNRLNERGLGDDGPCEEEFQLLEEDLGDIIAEVHDLAKFVQLNYTGFYKIIKKHDKMTGWHLRPAFETRLKAKPFYKENYETSVIKLSTLYDLVRTRGNPVQGDSAAGGSQASFVRQTTKYWVHLDNVTELKLIILKHLPVLVFNAGKAFEQQDSAITSIYFDNPDTWELYQGRLKKTEGAEAIRLRWYGGMQTETIFVERKTHREDWTGEKSVKARFSLKEKNVNAYLRGQLLPATIFDKARREGRKSEKAIHEDQRLASEIQYAVLEKGYRPVCRSFYNRTAFQLPADARVRISLDTELTMIREDNLDGRTRCGDNWRRMDIGIDFPFAQLPPDDVVRFPYAVLEVKLQTQLGQEPPAWVRQLISSHLVEAVPKFSKFIHGAACLFPDRIHLLPFWMPQMDVDIRKPVTHDFGIRRRPGTAGTTTTSSEDEEELDSDDDRPGPSSSGALPPPSSLVATGQAAAAPPADAEGQTADGVTDESFPIYDSDDEYDENYALDEARRVGGWRFYSTLFATKARALGHGALSVAKSLAPGPRASHIPPTQRHQMLFGSEAVQQRKFRAPAGKKIYVPVRVEPKVYFAAERTFLGWLEYSIYVGAIAVTLLNFGSQVSSLSFWTASLFTLLAIISLAYSVIIYLYRSSAIRSRRAAKYYDRWGPSVLCLSLFVAVALNFAFEGRDRGLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LK95</accession>
    <name>A0A367LK95_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">4Fe-4S ferredoxin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6709</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LK95"/>
    <dbReference type="OrthoDB" id="5186115at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016694244" description="4Fe-4S ferredoxin-type domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="103" mass="11117" checksum="533E78F5E34BBF34" modified="2018-11-07" version="1">MKPTSILSAIITMAVTCAATPGPLPMGVEIVERDGQTFVREVPHQLLGRGIEARCRNCVGQGGRCTIGDGSCYAENPPMYCTWCGDRCKSVCVRSGQRCPRHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKR2</accession>
    <name>A0A367LKR2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mob1/phocein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_6866</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKR2"/>
    <dbReference type="STRING" id="1330021.A0A367LKR2"/>
    <dbReference type="OrthoDB" id="10261121at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI15024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="373" mass="41338" checksum="832BA1237F71532A" modified="2018-11-07" version="1">MSNLFSGIASRTELAPVRDAVGWPDIACANARFRGGSGKPPAQLKSPSSPSTTGPTASAADSLSHASQTSANLAPKVPPLPNSPSLAQTIGMDESSGVLASGDDIINSYHLPRPLPLWVNGQYAKHIVRGNFMTLSARPKTVEQGEWIAHQIVEHYRNLWNFVRVLHEKEDDGTTICNSTTCPRMSAGTNHSFTWLNRQREPVELPAFEYMTLMQRWISGKIDDTNIFPTDPSAVSYAHNPAITTTPLAQLSNPGEPDWIGKRSGFPQNFVEVCQTIFRQMFRVYAHLYWAHFTDPFYHLNLEKQLNSCFSHFILTATALDMLKPQELEPMQPLLDIWAANGTFPPESKAYEYANLRAGERLLEMAGVEVGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LL42</accession>
    <name>A0A367LL42_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_6426</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LL42"/>
    <dbReference type="STRING" id="1330021.A0A367LL42"/>
    <dbReference type="OrthoDB" id="4685598at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF7">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="45"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="110"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="152"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI15156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="845" mass="92715" checksum="AE91E532BF8E692F" modified="2018-11-07" version="1">MDLSAAHGSAAPLATTNNTTLGPTPSAPSPPPTKRRRTAPVLADCCRTCRLRKVKCSGNPGNGACSNCARLELSCNFANAEDHDETTVSRTTPSHSHTEAGTLRKRAQRACSQCHSHKTKCSGDLPRCKRCEVANLPCEYTPAKRRFTNVRFQSSSAKPPDDNNPPASAASSARSDGIISPTLSSSSGAGPVSVLTDSPNLNAEDLFARKDLILRHMDAYMDNVYWLPSQGFVHPESVYRDIQQGTLDPVHAAGICAVASAFVNPTEAGRAFGQKCSTQIEFYLFQNVYKFSDDLLILFALNITFNVVQGSFAKVWQCFGIASRLMLGLRINWHVLPRGRSFIQQESLRRIGWHFFHMDRMLAGGYDEYISCRAENMRIPLPCDESAYRENRPVAAERLYDKPGKPPGTINLHAFQIRLIDLRHRIQVITKRLCSATGTNLQYVDASKIMADINGLQNELTRFHSSLPPDVLLCDQSIARYMAMPERPGYVFIHCHLAGCHVELYRFFLPGQKEKIPLEIVRKLPREFLARSQKQAVAHSMSFGRFCDAIQNEVDQMRDTGKQELAADYSTIQVGTACVRVLVAAIQHQLFRDISQETTAPLWRLGKTDEPHLRFLIKAVQRVTEPWCGILNMAQQAFDHNKTLLEDFDKSRKMADQRCADRAFRSRADGDNRLPGPDSLLASIATGTMEDTRRSLAVDTAGAADRWLRAAQVPAAGTIQYPGSPHGSGFGVEPGTPGIPLLLAQARTASMDPSELAAMFDSENAMMDMADLTGALPDGDGLMPPGDMPLMMDGSIDPAMYQQAPPGPSPGFLMAQQGIFMDSYGGPFANGHGDPGSYGPQTGYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LL52</accession>
    <name>A0A367LL52_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Karyogamy protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_6888</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LL52"/>
    <dbReference type="STRING" id="1330021.A0A367LL52"/>
    <dbReference type="OrthoDB" id="5559380at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051293">
        <property type="term" value="P:establishment of spindle localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031578">
        <property type="term" value="P:mitotic spindle orientation checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030473">
        <property type="term" value="P:nuclear migration along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013889">
        <property type="entry name" value="Karyogamy_KAR9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37271">
        <property type="entry name" value="KARYOGAMY PROTEIN KAR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37271:SF1">
        <property type="entry name" value="KARYOGAMY PROTEIN KAR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08580">
        <property type="entry name" value="KAR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="23"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="162"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="723"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="559"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="187"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="233"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="732"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="788"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="812"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="874"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="884"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="942"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="968"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="986"/>
            <end position="999"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI15164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="999" mass="106768" checksum="BDD26D7C3BFF868A" modified="2018-11-07" version="1">MAAVDPPNLRHSDNVVAVAAAAQDDDGARDGSALTLSADASTPPSLARLSLPPHAALHHLPPSPPETAADSAAAAAAAAATGRGSLTSALSAPSLLTHSPAQEASLTSLTPRLRPHSTARKPSPGLAARLRALGFGSSTKKASPRPETVGRLDEDQLRQLHEKLRAPSPLGPIVSKRGRPWKGPGESPTLLPSPSSSAPTTMDAHKYRTPDHTNGNGNKISLDTRRDMVRSPFPRPLTLPPSPPPKDTPPHSSDLDSSSSSYVPGLGSYFTSGRDRPGSIYTLSRASFANQLAQLTSLQLPDAESLSSKVSAIRNAQVAAKALINAADQIRSWIFKAHDVIGGLDGEDDVEWAAAGGREGLEEVESAIARFGHLINVYVGAIEELQARQDVSTVSSDDLRRAVSQMDTILDEWAKVRATLCGVRTQVEMAMEWEELWNSVLGDIQSEMDELSRLVFEMEERRHKTSASNGDGVDIGDLETIVEDSPTGAASRLRAPSRLSLAGLALSPTAPGSPSLSLDDSSLLALFARMQPLRASLDFLPMRLSVFAARAERSFPTACEELEMRRNGLDASYRKLEKDAESLRKELGEDRWVIVFRGAGRQAQKMLESVQRSLQKVREALDAGLQLSSPAATTKKIESYEAKKLHYGPAIERVLSIIEKGIRDRLTVNGEILRLHADTQSRWEILKARIVDMDALLDDMPADRKGQQQLRDSVSSLLSIDRSTLGSGHETPGSSPPSSVIMSSLGLDPHTPAAKAKVSSGNNKKRSSPPLASSQTARRMGVRLSTIPSAAPSSSPSSQSSRPASSVINRPRWNTSTNVSKLDTSFNNLSPLSAATPSPYTRSTPGGLRSVSAFSPPFGSSRLPAPRSALPRATSESPSVRQTFSRSRFAASPASSLPSPGPYSQQFVSKPRTLLSKSSMSALTPKRRSAANRSADGAPVNRPASSLALTSRRSSLLPLPKDKPQDNSAGRTSSRMSSASRSSTRRPTEGKESKPKWRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLE7</accession>
    <name>A0A367LLE7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_6655</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLE7"/>
    <dbReference type="STRING" id="1330021.A0A367LLE7"/>
    <dbReference type="OrthoDB" id="429467at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050403">
        <property type="entry name" value="Myosin_RLC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23049">
        <property type="entry name" value="MYOSIN REGULATORY LIGHT CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="125"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="195"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="16"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="96"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI15082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="293" mass="30696" checksum="B273128EE1B3E4A5" modified="2018-11-07" version="1">MLTGLICQSASTAYKPSPLGYGSSPSRSSPFRRPESPASPSPLRHATPTTSPTKTGPSSATPTTGTAKLSRLGLGSSTYGGPAPRFALAESPMTSSPPRASAQSPRPAAARSLSNGNSLSQLQPSQVRTLRDGFQILDRDCDGVVNSDDVADMLNQLGLPNRPSDVARFFPPSRPQTMALAAFLNSLAEALTALSPSTELLSALSAFDDDDSGQVDWAELREALLTTVPEPGERALTAAEVDRVASGFTGRRAFNRNMSTQLGAKKGEVFRYREFVNSVTGSNGGGPHEGGED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLF9</accession>
    <name>A0A367LLF9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphatidate phosphatase APP1 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_6557</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLF9"/>
    <dbReference type="STRING" id="1330021.A0A367LLF9"/>
    <dbReference type="OrthoDB" id="2117591at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017210">
        <property type="entry name" value="APP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019236">
        <property type="entry name" value="APP1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052935">
        <property type="entry name" value="Mg2+_PAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208:SF3">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09949">
        <property type="entry name" value="APP1_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037464">
        <property type="entry name" value="UCP037464_APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidate phosphatase APP1 catalytic" evidence="2">
        <location>
            <begin position="327"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="657"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="550"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="657"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI15249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="734" mass="80138" checksum="44835BC7704F02E0" modified="2018-11-07" version="1">MPTLAELTAGYGDGGSQETGERAERGYRRRKLAAMAGNLYRSGQQAVTDFRESYAQVRARGLDDEALILSGSPHIPGSFPDVAITSQGDEQMVLFPSYAKRHVRKDWSQQTADAGEEHFWRQEWERHEDEKAVVDVDVRGWIYSPQMGPMTKRNRMLIGLARQLSGVPAPSNKPEGREETVEQEKVAQEAAMIERRGREQQRLAATTGTASSASTSRLRENLAAPGSRTASPARSISNEMSEAELVLANANLMARVAPFLTSPRAALPMTIFFYNDEQSQSRTVSTNDAGHFAIRAQLDFVPTGIRVLANERLSAMQDVTVIEPRGVSLISDVDDTVKHSNISAGAREIFRNTFVRELADLKVEGVEEWYGELDGLGVSFHYCSNSPWQLFPVLASFFKLSGLPAGSLHLKHYSGMLQGIFEPVAERKRVTLNELFSDFPHRKFLLVGDSGEADLEVYTELALANPGRVLAIFIRDVTTPAEKVASFSEPTAAPELELRRLSNLTLDDGLPPLADEKPVPPSVSSKPVNGTAKTAEVLIDFSTEPEEKSPAQQGSKTKGTSAVDLLSDRRPPPPAKPASLRGRRPVPKPSEAGQPESKGPSPPRPPPPRRTGTSSTKRLSPPTRPVLNRSRSSQSETRDCDPSSLASLTSYWSGTTTSPPAAAAAATATATTGSPVLGPNKKLDLWLRRLERANDLLERGGVALYTWRRGQDVMVEASAIVRDALREMGEERGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLN8</accession>
    <name>A0A367LLN8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLN8"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="95" mass="11183" checksum="26BDFAF4558461AE" modified="2018-11-07" version="1" fragment="single">MQNTHAFHIQSIDRRQVRILFRMHRHSSPLGRCAKQCLDSWSREKRERKKKKRFTALLVSLPTATQSGIIHLLFHLPPFSLRHSVTSALSRRNEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMA3</accession>
    <name>A0A367LMA3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3498</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMA3"/>
    <dbReference type="OrthoDB" id="408760at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00229">
        <property type="entry name" value="SGNH_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051532">
        <property type="entry name" value="Ester_Hydrolysis_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383:SF19">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30383">
        <property type="entry name" value="THIOESTERASE 1/PROTEASE 1/LYSOPHOSPHOLIPASE L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="242" mass="26837" checksum="BA03F787D27FAD3B" modified="2018-11-07" version="1">MNRPQLRILCFGDSLTCGYSDAGLQPYSQRVCAMLRTALPAVAVEVVDDGVAGDCVTGPGFRRRLRQAFDGAASPFNWVIILGGTNDLAYAHEAADIFDALESCYNLVIARGGRVLALTVPECSAKLAWIDETRKSLNESILAHRQKTCDFALDLFSKIPFHSLQQSDKEKFWDDDGLHLTPDGYDWMGGHVADGLLRIIKPSEPSRARRLTSDDNRVFDEEDGSPDEISRGYVVVRRKDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LME0</accession>
    <name>A0A367LME0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LME0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="213" mass="24114" checksum="7A11A847FFE624AA" modified="2018-11-07" version="1">MDQRSRRLRPPPFRNPGTATSVLAAQCASLLRPRFVRPPSQPCRSGEAEARGMRPPAEERRARVACAIGRFQATLSGMTFGSRENKMSTGTQTLLDRERVHRHLVCLCQMTALVKDGYLPLMQCHVRMMRNTSAALSSSLSKKEKPPQSDNVAHNQKADHRFFFFFFFEVFNFNATSPVRERPSIDTPPPRRRAGSRAKPTGLVIRRCRNLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LN58</accession>
    <name>A0A367LN58_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_2716</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LN58"/>
    <dbReference type="OrthoDB" id="4524805at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="207"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI15883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="397" mass="43456" checksum="6B33FCD26F91F1D8" modified="2018-11-07" version="1">MPFDARQATDNISPRHSSDQLPVALGAIFAAYGISLVFVAITLLALSSKRRQHLTADFPPTIHYAPYHNFPSPARCTAVPNFSYPSPVRQDFSSSSRSPNSNDASPVARIDYDDDVEMAEQQQLEDMYKHAMDHEAARLDGQDFVPSPSLKSPRPSHLTLDQKPKSKTQGFLDAIRTPRKKNIKGINISSPIMSPHPSPHPAQYSRPLSPVSPSSYGSSPASQPSYRSPPRTARHQSPPLTPEISPRTIPSIDEHLNAYLNSPERRRPSPPVGLPRSPKPGAGFPPMAPVPTIGTVRRPSAVREGGLLPLRAYDPGKLGAGSATTIQTVLERKEPEGPMSGRGPLSAGTVPYSPYQPYTPCMPITPSLVTREDRKRMKKMMPKTPTTEMVKSTEDVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LN77</accession>
    <name>A0A367LN77_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1939</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LN77"/>
    <dbReference type="STRING" id="1330021.A0A367LN77"/>
    <dbReference type="OrthoDB" id="432970at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="373" mass="41920" checksum="F9CA4EB2AECC906D" modified="2018-11-07" version="1">MRLETSHLHSNSLKGRKISSQRCYRWRQMKQKKLPLRRVSQWMNRMGGNRPKVRQIKNHPLQSAEVLEQSLERSTITITTVTVTTIRATKLLSLEKKKIPKKNQNQKSKIKTEKKKNSSSPCHHHPSAKSAKNPPLKSPSSNAENAAQHPTAQQNAKRQTGKTTRERAETPPPPPSSSSSSSSASAASPTLSPPKGLDKGVALPFTRLDNHTWLHDRSERDVYRLLVDVYRLRVEDMYRIEGQVVEDSLYEDEGADLLLGFRRFLGMVQGCSRHKLLPSWWTGEKKKECEALGMSRSQWHSLNSALPKSDVVEHYGDPQFPMQLRMFGEAVYGSAPGGTDGTAMRRMMAAMEKGMMGDMAATHLDLSPVFGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNF1</accession>
    <name>A0A367LNF1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">L249_2520</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 16">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNF1"/>
    <dbReference type="STRING" id="1330021.A0A367LNF1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000040">
        <property type="entry name" value="Bifunctional cytochrome P450/NADPH--P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF108">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="6 16 17" id="KW-0349">Heme</keyword>
    <keyword evidence="14 16 17" id="KW-0408">Iron</keyword>
    <keyword evidence="9 16 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15 17" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="13 17" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="binding site" description="axial binding residue" evidence="16">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RCI15940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="20">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="503" mass="56031" checksum="966CBF0213CC3251" modified="2018-11-07" version="1">MSYSQLVQPKTGLGTMADIPPAPFEMQKQRDSRSAVSATYIRGRNDKITAMSQPIPKPSGVPILGNIFDVNPSNPWESLKGLSETYGEIFQIKVLGKTLVFVAGVELAEEICDEKRFRKFVGGPIVEIRAAVHDSLFTAYDHEESWGVAHRIMMPYLKPDAVAGYFDSMRDTALDLMEIWKSGDGVKAVVPWKDLARLDLETLTLAFFGKRLGCLMGAEHPMIQAMEDSTAEAVMRPTRLGIVNWLFYGGKFKRSNQMLRDYAESLVGYRHEHPTDRQDMLGGLLNDKDPQTGKCLTPSQVIDEMVSMPIGSSTAPCLVATAILFLEQNPEAKKKARKELEAVVGGGELRHEHLSQLRYVEAVISETLRLSCAAPGFNIEPIPSKDKSPIVLGGGKYQIAHDQAMILLLAGVNKDAGTFDDPLAFKPDRWMGGEMRAGARKWFGNGKRICIGRHYAWQWSVTVLAVMLREVEFQLVEPEYELKQDGWFNVRPVGLEVRVKGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNP6</accession>
    <name>A0A367LNP6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">acetyl-CoA C-acyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_2624</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an acyl-CoA + acetyl-CoA = a 3-oxoacyl-CoA + CoA</text>
            <dbReference type="Rhea" id="RHEA:21564"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.3.1.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the thiolase-like superfamily. Thiolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.16" evidence="7"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNP6"/>
    <dbReference type="STRING" id="1330021.A0A367LNP6"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003988">
        <property type="term" value="F:acetyl-CoA C-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010124">
        <property type="term" value="P:phenylacetate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00751">
        <property type="entry name" value="thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002155">
        <property type="entry name" value="Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050215">
        <property type="entry name" value="Thiolase-like_sf_Thiolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020610">
        <property type="entry name" value="Thiolase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020617">
        <property type="entry name" value="Thiolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01930">
        <property type="entry name" value="AcCoA-C-Actrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853">
        <property type="entry name" value="3-KETOACYL-COA THIOLASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43853:SF5">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02803">
        <property type="entry name" value="Thiolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000429">
        <property type="entry name" value="Ac-CoA_Ac_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00099">
        <property type="entry name" value="THIOLASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="11">
        <location>
            <begin position="20"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="12">
        <location>
            <begin position="280"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-thioester intermediate" evidence="9">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="361"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000429-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI16065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="403" mass="41863" checksum="45846099B905D277" modified="2018-11-07" version="1">MSLLPQRGLAAIRSSSPKDIVILSSIRTPICRAHKGGLKEAYAEELLATVLEATRRRLPPSVRVDDVSVGVVLSELGGSKAARAAVNHVGYPAEQTSVYTVNRACASSLQALASVAAALRVGDVDVAVAAGMESMTRNYGSRAVPTDPWPGIVASDVKDARDCLMPMGLTAEKVARRYGVSRAAQDRFAAVSHARAAEARERGLFDAETVAVTLADGSVVTADDGIRQGTTEEKLGRLPPAFVPDGSCTAGNSSQISDGAAATVLTTRRKATELGVQDDILGRFVSAAVAGCRPDEMGVGPAVAVPRLLDRLGLRVGDVRWWEVNEAFAAQAIYCLGALGLDKAWEEGRVNARGGAIALGHPLGATGARLTATLLHGMTPGDLGVVSLCVGTGMGMAALFVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNW6</accession>
    <name>A0A367LNW6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNW6"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="89" mass="10256" checksum="AB01B0E4C99218EA" modified="2018-11-07" version="1">MTLGWEKRREKSSGIKGKGWHKLGRKNEKKKKHIQKERGQRAYRETLARQLCMRNEGSQGRGRRFVKGESDLGMISFFLSYLGSIGLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPD2</accession>
    <name>A0A367LPD2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2826</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPD2"/>
    <dbReference type="STRING" id="1330021.A0A367LPD2"/>
    <dbReference type="OrthoDB" id="2504266at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046784">
        <property type="entry name" value="Eap1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20566">
        <property type="entry name" value="Eap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="311"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="425"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="485"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="580"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="593"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="664"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="700"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="750" mass="82022" checksum="A8C37E883D3A3AED" modified="2018-11-07" version="1">MAVRYSAAFLLHLRDSPLCTRPENLPPAEEWMGPPPDHRTQNKAAADRLRPNDNPLLDQTNRRPGIDRSRSSANPDDIVFGPPRTAFHSARGNKALDADKAAKELDSHSRGGLRGRNGDTDGDRQRESRNPNLRRSDTDPDAEGWSTVKPRKSFGAEGAERFHGKMGGNFRDDRRAIRDRDDRDGTRDRPTRPYDTFVRDKDGGDGETRPRNGLARTKLDTWRSGDLKDGSHPEKRDRDRTKSWRDRDRETEDDRASGRTSDRRWGRDREQKNERDPEWLDGPQVEQREAHTQQDFQKWMEQMKAAKSGNAVSVKPAAPAASEVPTEASKPTVDAGPDKFFMAFGGSGAALDAASPSEQPKDAPTKAKPAGKSSRFTSFFSQSHHDGRAVSEGSASLAVLPANETPPTVGPTVASAPAPEEERQAFQQLLAKLQKQSMSATPPGPSPFSAPPQGHPVDSGKNINAPDYFGRDRHDTSQTPHEILAPRPQQQPARPDQLLQDFVGHHQRVSSRGSLRTDVSSALSKSNAEFLMTLMKPAVDPQRADQQPRVPQPQKPGQMTILSEREAEYLGRENRGVPRQPRPLPPPGFPMDEPFHGADQEQRQSQPTQILQRPPPGLDQIPPEWMARGGQMPPPPPPPPQRGPMMPPPGLAGGPSRNMTLPHMFPPNFPPAGMPPPPPPPPDAMGAMAPRNMPMPPPGFFNGPPHGFVPPGLGGFNGPPGPESHAFGGAPFEGRGVPPSNGRGASFGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPD6</accession>
    <name>A0A367LPD6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_1785</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPD6"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI16102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="114" mass="12924" checksum="D61C00464E9F48BC" modified="2018-11-07" version="1">MNRGYNPWLWGRLIWDGGLDFGNLEACRHNRRCTMQVSLDGTTFAYTRPRSPAIGPRSYGYEELGSVICSGPATLPVSDKRQCFFFPIEATTGADNVRRVWICNHELDGKQRVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPE2</accession>
    <name>A0A367LPE2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_2171</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPE2"/>
    <dbReference type="STRING" id="1330021.A0A367LPE2"/>
    <dbReference type="OrthoDB" id="2975793at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF12">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="98"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI16279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="629" mass="70307" checksum="340980198B9002DC" modified="2018-11-07" version="1">MPESPQPKRRSFAGRLIGSFRQARREVAASADSPQRRDSPASAGQSPLLHIRQWLEACNADHGSHCLSGAADAWRPRRLVDVVERRLACPTPGERWEYAALSYVAGVRSLRAPRLLASSVEAFQLALPDAALPATFGDAIWLTRKLGLRYLWIDRLCIVDDDADDVADHALHMASVFASAHVVIIAAHGDADTGLLALDPRRGKPSDRDHDDLVRASRWNTRCWTLQERIYARRAVYLFEDSISWECHCEVWQGSQAPRGKRPACVDGVSSAPLCWAHAPWPDMDEFARIAADYSARSLTLVDDTIRALLGVTHVLSRAFSGGFVYGMPLMFMDAALLWRPQAMIRRRALSRPPYVPSWAWMGWWFDGIPVDLSLWRASTDYVEETRAAKRGRGPERFRATHSFRLKSTVTWHLTDRMQTVPVASTGLRYRELRSRRSSGASLPPGWSRTGSHFRHDSDSHTVFRYPVPVEDPAREKGDGGDNGGGPPLPGPLLSFRTTSAMFEVDYAISMVLRDKANPPMAVGNIWSRSNRWIGELRSHDGWLGVQTSNYDGAERLEFIAVSSATERRGSHVFGADRFEENMDADEAVDIVNVLWIERIADVAYRRGIGHIVQQAWEAEAVAVDVLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPH3</accession>
    <name>A0A367LPH3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SMP-30/Gluconolactonase/LRE-like region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_3160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPH3"/>
    <dbReference type="STRING" id="1330021.A0A367LPH3"/>
    <dbReference type="OrthoDB" id="4405280at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016811648" description="SMP-30/Gluconolactonase/LRE-like region domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI16328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="392" mass="42976" checksum="53B08762C5B861E3" modified="2018-11-07" version="1">MILVILALLLWAATTANAHRVCPLGGDTCAVTVPPICPSNMPESEHMRVPSSRPEPKRPAPNSYPPRPAPWPEPQRPVPAPAPQQPPRPAPTPAPRQRPAPAPQQPPRPAPQRPAPPPRPAPPPRPAPPRPAPAPQSPRPATPAPTFPCNHDAYVIQDNHLYQMDLSSGSKRQLSDQIKGHIAGLVYNTFDHLLYGLDFNKVVRIYRNGTTEPVRELPFVPTMGAIDMQGRYWVSTVGKDYAAVDLNPNARFPGALLTSGKSAFRRTGVRMRFPTGWTISHIDPFHAYGIGFDYHANRPALFRWESLTATWEHVSTGTEMVGGDSFSAVVATGDGVIYGLEDDTGDLVFYDLEEPYKMSVLRRVGPVSTRMPKVNTAARCPILGDSRPRRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPJ2</accession>
    <name>A0A367LPJ2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPJ2"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="79" mass="8634" checksum="05DF744EF07A8543" modified="2018-11-07" version="1" fragment="single">ELEKGREEDDDEVVADGSLGGGFAVSVASPPYPTTLAPPPSILHLTMSTKALKRWKDKTRPFFFSSPHQMASIMSRADE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPJ6</accession>
    <name>A0A367LPJ6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2823</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPJ6"/>
    <dbReference type="OrthoDB" id="4920868at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016685718" evidence="1">
        <location>
            <begin position="17"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="147" mass="16433" checksum="9E6D37F8783F4D2E" modified="2018-11-07" version="1">MRPSTLLAVFATSAVAETVVPMLCHNTISSDVFVGIVLAGGDRVDWISDGAWALNTRSLDGFKCMVDGRNIRDYDFGGEVARRHELQLLCRKWYQNDWTGFIRSVKVRVGGGKRPEVIDEDNTDVGINFFTGRIRRYCMVSKLVSVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPW3</accession>
    <name>A0A367LPW3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Glucan 1,3-beta-glucosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_3278</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPW3"/>
    <dbReference type="STRING" id="1330021.A0A367LPW3"/>
    <dbReference type="OrthoDB" id="4910908at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF16">
        <property type="entry name" value="GPI-ANCHORED CELL WALL BETA-1,3-ENDOGLUCANASE EGLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0134">Cell wall</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016760683" description="Glucan 1,3-beta-glucosidase" evidence="9">
        <location>
            <begin position="19"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="22"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI16485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="414" mass="44379" checksum="436A43B54C54E755" modified="2018-11-07" version="1">MLLKSVLIASSLVTTSLALASPHDGHHHHDSHSKDDKSIGATTAPTTSEGTAQYPSVSSGASTPTPTPKKESNDDWSHKTVSDFEQEFTAAKSLAGTNGQFTSVRLFSCVKPETDDEMTPAFEAAVKTNTSILAGVWASGGKGIEGEMSALKKAIEKWGSKFTDLLIGVSVGSEDLYRSSEAGKKNKAGEGNSAEKIVDYIKAFRKAFEKSPIAKVPVGHVDVWKAWKDPSNKAVIEAVDWIGLDAYAYYDDDMDNYVTNASDLLDMAVAATEKAIKEATGSSRPIWLTEIGWPVSGPEWNKGVASVKNAKYFWDDIGCRRLFNKVPTFWYTLRDSNPQNEMKFAITEKGDLNKARFELGCPAGSDSGFDSDKAAATGAPDVDQQRAGASSAKIPGVMSCTVLAVVVGLCAAWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQA2</accession>
    <name>A0A367LQA2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GrpE protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_2436</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the GrpE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQA2"/>
    <dbReference type="STRING" id="1330021.A0A367LQA2"/>
    <dbReference type="OrthoDB" id="201635at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.22.10:FF:000002">
        <property type="entry name" value="GrpE protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_CC"/>
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    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="GRPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237:SF23">
        <property type="entry name" value="GRPE PROTEIN HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="Coiled-coil domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01071">
        <property type="entry name" value="GRPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="46"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI16567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="275" mass="29912" checksum="6E32D2255C5B7A27" modified="2018-11-07" version="1">MLRQSLSASLRAASRSTTLRVASVRKTPISLPPLARPIQLAWYSEAKETSEKEAPVKEQNPATESSSSDASESSSSSSSSSSSSSSSSSSAGQSQDTTADPVSELKKALESKDKEARDWKDKCLRSVADFRNLQERTKREVKTARDFAITKFAKDLVDSVDNLDRALTTVPPEKIGAAEKSEDLQDLANLYEGLKMTQTILLQTLVKHGLEQLNPEGDQFDPNEHEAIFMAPMPDKENNTVCHVQQKGFKLNGRVLRAAKVGVVKNNGEPSSASS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQD6</accession>
    <name>A0A367LQD6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4604 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_2479</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQD6"/>
    <dbReference type="OrthoDB" id="5388322at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027911">
        <property type="entry name" value="DUF4604"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15377">
        <property type="entry name" value="DUF4604"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4604" evidence="2">
        <location>
            <begin position="5"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI16452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="166" mass="16856" checksum="1F8B1765CBACE7EE" modified="2018-11-07" version="1">MSSSKLRYDAALPPFLAALRAQAVESGGPDAQASARRRVGHKRSASEEAEDGPLVVDERGHAVDVTDGHRAGLDHDDAVAAAAASSSAAAAGANPPPSSSSSSTAVATAAADGKKEKKPGAIGPRRRRTGRVVGQDADSASEPATPSKPKKKPTKKIKLSFDPDQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQF5</accession>
    <name>A0A367LQF5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_2883</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQF5"/>
    <dbReference type="STRING" id="1330021.A0A367LQF5"/>
    <dbReference type="OrthoDB" id="548867at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000747">
        <property type="term" value="P:conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05992">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06890">
        <property type="entry name" value="PX_Bem1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1520.10:FF:000041">
        <property type="entry name" value="Protein kinase activator Bem1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035550">
        <property type="entry name" value="Bem1/Scd2_PX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051228">
        <property type="entry name" value="NADPH_Oxidase/PX-Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706:SF2">
        <property type="entry name" value="SH3 AND PX DOMAIN-CONTAINING PROTEIN 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15706">
        <property type="entry name" value="SH3 MULTIPLE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="5">
        <location>
            <begin position="158"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="PX" evidence="6">
        <location>
            <begin position="469"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="7">
        <location>
            <begin position="655"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="232"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="382"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="599"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="607"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI16472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="734" mass="81187" checksum="3BC1C6104F27C4F0" modified="2018-11-07" version="1">MYLDPADGQARRYPSQPLSPASSLSPTLTLSHSLTLSPSRRHPLRVSRILFDPAHQNWSPAPPPSADAADALGPVLARQLSHETLCDDALLPLTQGPTRSLPRALPRHTSLPLSDSVIARPRDEERSHKMKALRRSMKGEKHKQTPSIGSKSAVAIVPPKKVIRANDDYQPDDALLQSFAKAGVQVLSFSKGDFFHVIGREDDPHWYEACNPALPDARGLVPVAFFQVLGRTERDSADGGRQPMVKNPDHDSGYGETAIQQSAAPHQRNSKSSKTAGTVYAKVRHSFTAHPARPDELSAEMDENLIIIAQSNHEWVVAKPIMRLGGPGLIPIDFIYVFDEVPLGANTPPPVADPLEALRKAGVPSVEEWKRMAAQYKNSSITLGKFDGSRSPGGQQSPLEQGMGRLSLKPGARPSDANGSSVSRRCTALSPMPSRLTCRRRQQPGEYLNSPDAGPSPVLQDAYGSRAASQLSAPVWARIPRYCYADQKYWFVIETEHESGRCWELSRYYQDFYDFQIALLADFPIEAGNTPTQKRTLPYMPGPVSYVTDAITEGRLYNLDAYVKNLLNQPPHISRCDLVKLFFAPREGDYEIDSHATGEEEYRLSEGSHQSSVESRNNATSRRSTPSNGNGYGYSGLSATPRQGNGSLQGSGQSVLKIKVRFKNEVFAMRLPKDVQFQELYDKIRERVKAAPGEQIQLYYQDELSGELQNLLSNSHLDYALQRQDKLTVYVEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQQ4</accession>
    <name>A0A367LQQ4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2789</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQQ4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="263" mass="29532" checksum="EDB04D06339CEAAB" modified="2018-11-07" version="1">MCAHRYRERWRFGVLLRVVRARTEEAFVNCHISRGRLDCLSVFDSGGPWHVSCDAVSVRLGQDKPLSMDINNGDSKIRDLGPPPRRVEGEEKKKKYDDGRSCGRRAGRRRSRARSGGLTHPHDATTPGTLHFSPAQYEMIRQFTRWEHETTQQTGGGGENNPPRLTNQSGCLLLIALCGGLSIAYPVRQGRVIRESSGQIHILPPKPFYPLHKLREPASIRTTVGLLQQTGGSHHESHGLKQSEAGISGPRRRLWLPKIWQTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQZ4</accession>
    <name>A0A367LQZ4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_2704</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQZ4"/>
    <dbReference type="STRING" id="1330021.A0A367LQZ4"/>
    <dbReference type="OrthoDB" id="412383at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF28">
        <property type="entry name" value="DIOXYGENASE FAMILY OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G09600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="4">
        <location>
            <begin position="319"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI16831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="928" mass="101719" checksum="5FBE5D52F91D5A56" modified="2018-11-07" version="1">MAITTELTRRLGIRVPVVQGGMMHVGTADLAAAVSNAGGLGIITALIFPSAAALRDEIRRCRTLTRNPFAVNLTLLPSMVPPDYGSYAKAVVDEGIRIVETAGNSPGPIIAQLKKEGVTVLHKCTTIRHAQSAVKLGVDFLSIDGFECAGHVGESDITNFILLSRARQSLGGVPFIASGGFADGWGLAAALCLGACGINMGTRFMCTVEAPIHQRIKEQIVSADETDTILLLRRWRNTSRLYKNTVALEALRIERESQKGEFAEVAPLVSGKRGREVFVNGDPDHGVWTAGQVIGLIHDIPTCDVLVKRIETEAEAAEIASLTNLPDHLLADIIDYFDTARDVSSLSRSSRRLHSFVCHGGGWRSFAYKRFPTLMSSAPDMALPWNAVVDRLTYLDRCWDTRALLFTSFREDQNVRRGRRKRGEQSVDFQVMVSALAQPFSPHETLVYSAGEKLHIRHRHIYGPVAGSRHDSWFTLSGFYKPGPGDVTALSLIERDSKLEIIVGRADGSVRLIAAGDDAVGRPLGHLLPGHPLGDSPGRLAVMWTEWHPQTRLVASCRDSFLTLHDLSKIESRCGGYEAKLAPIDHFDATPANHHAFVRCAKFFGSDGIACGISGSPRPLRWGKIRPTGLQLTGSTADRPCSKQDSTQMVMALEQVGGQAHENLLLLDLRTPSDHDVVYRDRHQPHNAGASLLVYGMERFVAGSHSEPVLRLFDFRYPKPYHQTTAKPCHSQLLSPRLDWGYSTSHQDEDSKTDAAEASNAPSWVLECEPGRDRVCVWHEHARKHEWRPDANVFLGSSRHDRVASLAKASDLSDAFYCGLRGAMVEAALHGGGVDVDGRPLYADARSPPQGCVAKANEGGIRRISLLETGIGRRTAGSWSELMPKTTLYTYGDVVPGCRVASVGEEHMRHGRLSGRWYELERAPRRAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRT0</accession>
    <name>A0A367LRT0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7923 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_2361</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRT0"/>
    <dbReference type="STRING" id="1330021.A0A367LRT0"/>
    <dbReference type="OrthoDB" id="3512845at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057683">
        <property type="entry name" value="DUF7923"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37543:SF1">
        <property type="entry name" value="CCCH ZINC FINGER DNA BINDING PROTEIN (AFU_ORTHOLOGUE AFUA_5G12760)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25540">
        <property type="entry name" value="DUF7923"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7923" evidence="2">
        <location>
            <begin position="121"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="63"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI17153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="295" mass="33158" checksum="73F6B66FDFC5A52F" modified="2018-11-07" version="1">MAHIVFRPPEEDPVVPGMVLSLLVGSANESENDTLVINVKISATTPDGEQVPPRLLQRNITVTQETKEDTDRLEAQIRENQELRRELRRCKFKLADATYDRQELRQVKELLRAHEMGLHQAQFHDHMLQQGAKGGRAAAQALQATVADHFGNRLGRFEVIVRVMVDFERLAQALGGDDVETRLRDFAYGFTETPAMFKFVGLRQTVDMASTRLHEMADWHLQNCNCRHVILGLKGTDANIGYLHKLIMTGHDVNHVSILPTRQLLEAATGVFGIVDWTGDYFRNYSSGTDGAGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRW3</accession>
    <name>A0A367LRW3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription initiation factor TFIID subunit 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_2367</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAF13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRW3"/>
    <dbReference type="STRING" id="1330021.A0A367LRW3"/>
    <dbReference type="OrthoDB" id="10266074at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07978">
        <property type="entry name" value="HFD_TAF13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003195">
        <property type="entry name" value="TFIID_TAF13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380:SF5">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11380">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID/SUPT3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02269">
        <property type="entry name" value="TFIID-18kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="109"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI17151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="159" mass="18209" checksum="472D0F411D51AA9E" modified="2018-11-07" version="1">MEPRARAGKNVGKMNFSHNELAQLLYAHGDVKNPLPDTVKVLDEILTDFMQSIAFEATRVAHYSGRQKIKYEDFEFAFRKNPSFLGKVQEVFEKQREIKKAREILREGEDEIIKDAADEEKKREKKAEEKAARPAQTEEELGEADDDVNAEADALGKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRW4</accession>
    <name>A0A367LRW4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_2812</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRW4"/>
    <dbReference type="OrthoDB" id="4926767at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.210.10">
        <property type="entry name" value="Heat-Labile Enterotoxin, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI17158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="301" mass="33368" checksum="4BAC26C4349C81E5" modified="2018-11-07" version="1">MPTFPYYGILKTEMPALGPTIHPTLKKPGADWLRNWQLLSSPVEQRPAKAKKSCKHGGRRKSAQLADLLSRYSKSKKNNDRFEIGRGDSKHTNVTLENPPAAYVFHPSHLLPSAAEKRTGFLPPKPDEDVGFGAFADLPTAARRAAVLKRDLGGNATLYLVHPTPNMVPDPDFGGYFVVAGIRYDQVIGSISLPDDLSYEYLGMLEAGLKMESPYDEAFYSKNKAYKPEKYDGYTFTDDVPLGSLKSREAAKAFMKTKGAAVDWHGDFPLFQPPRDSLSEWLKPAAPDTKPWLRGQGRVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LS05</accession>
    <name>A0A367LS05_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_1864</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LS05"/>
    <dbReference type="OrthoDB" id="5233297at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI17140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="243" mass="26780" checksum="1F940AEFE2CA9845" modified="2018-11-07" version="1">MTGRRLAIVTAAVVANHVRRMLVAPWLGQALWRHPVEAMKLARWSPHGYLEASLADVSWPAVALWLCQQVILSELLSQAAARSAKPSTNSSLKVNCHRRRQGKADAYRVLLLLAALTLAESSYAETCWAVALIGSTARLLFYNGQPERDFAQRLLGANPARAALLACLVLRWFRTVALPHATWLAASLRSLKVVLPAAACCVGASTVHLVQHSNRYFLVIEMSDMLVTWGWSVILWALATAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LS70</accession>
    <name>A0A367LS70_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_2446</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LS70"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI17237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="94" mass="10872" checksum="0767E569CD15FEA8" modified="2018-11-07" version="1">MPRGAEIESTRERESGLGEITASCTCYISTEWACNACQAQALLISSCIRVRILMDEYQQIIILCIGTKVHVRLYRLRNRDPQRLCCRQQYARMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LSF8</accession>
    <name>A0A367LSF8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_2510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LSF8"/>
    <dbReference type="STRING" id="1330021.A0A367LSF8"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050560">
        <property type="entry name" value="MYB_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614">
        <property type="entry name" value="MYB PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614:SF238">
        <property type="entry name" value="MYB-LIKE TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="155"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="155"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI17339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="271" mass="29980" checksum="313AF0F18B3B7F2E" modified="2018-11-07" version="1">MQQWQVGPVPEYVYSNSTHPPNDMHSNHPYQADMARRNERMEFPYGTPQTSMGAQQQHHPTPVQPPMNVPQQPPPQPGGSQQQTPTQTPAQPNRQRKRAAPNAAQSPAVPPAPVTPSQVQPPAPTPPAPQAAPPGPSQSQAEDANASPVAQPPAKKSRTNTPWTPQEELRLKQMRDAGNSWAEIAKTFPTRTEGSVKKHWYKDMHYAEFAEDESQALMNAIKEYENNKWKVIGQKVGKPAKACEQYAKEHFPGMFSKAGREQGPSQLAQLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZU1</accession>
    <name>A0A367KZU1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5671</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000024">
        <property type="protein sequence ID" value="RCI07691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZU1"/>
    <dbReference type="STRING" id="1330021.A0A367KZU1"/>
    <dbReference type="OrthoDB" id="5330139at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI07691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="184" mass="20204" checksum="9B7BB3A5BA8C47D5" modified="2018-11-07" version="1">MKKVSANNLNAACLQVELTSVAKRMPPSIDSHASSSHAAKAFHDAKAELVTLGAAGSLTTHKIDVFMGEPHETYVIFSKDIGFAIRSAIARQTGVCLSLDPEKVPLRFFHTSRHFAHAAIPYPRIIIERDLPRQNAGDTSPATLWLWGASHSLTLDGTPDNEFEESSRESHDRLKGAAELLRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L094</accession>
    <name>A0A367L094_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="19">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">L249_5776</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="19">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17 19">Belongs to the E3 ubiquitin-protein ligase UBR1-like family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UQCR10/QCR9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="19"/>
    <dbReference type="EMBL" id="LKCN02000023">
        <property type="protein sequence ID" value="RCI07827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367L094"/>
    <dbReference type="OrthoDB" id="26387at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16482">
        <property type="entry name" value="RING-H2_UBR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19673">
        <property type="entry name" value="UBR-box_UBR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.30:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase UBR2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.260">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2670">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003769">
        <property type="entry name" value="ClpS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042065">
        <property type="entry name" value="E3_ELL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044046">
        <property type="entry name" value="E3_ligase_UBR-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008027">
        <property type="entry name" value="QCR9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036656">
        <property type="entry name" value="QCR9_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039164">
        <property type="entry name" value="UBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055194">
        <property type="entry name" value="UBR1-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497:SF24">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497">
        <property type="entry name" value="UBIQUITIN LIGASE E3 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02617">
        <property type="entry name" value="ClpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18995">
        <property type="entry name" value="PRT6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05365">
        <property type="entry name" value="UCR_UQCRX_QCR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22960">
        <property type="entry name" value="WHD_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81514">
        <property type="entry name" value="Subunit X (non-heme 7 kDa protein) of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0249">Electron transport</keyword>
    <keyword evidence="16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 19" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="10 19" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12 19" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 19" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="21">
        <location>
            <begin position="164"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="18">
        <location>
            <begin position="164"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="483"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="589"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1668"/>
            <end position="1687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1718"/>
            <end position="1746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="488"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="595"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1718"/>
            <end position="1734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00046341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU366018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="RCI07827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="2271" mass="255912" checksum="54F929F101DD2460" modified="2018-11-07" version="1">MLFSTLFKRNYAMLAAVFGAGFVFEMGFNSTMDKFWDSYNRGVRTKRSSPCWKNIPGQSAHTRRSVNGKTSGADTSNRMRRRAFESSEQQLCQLLADLPVRFNYRYTEEASRELLGSLFWSLAGGNHDYLRLFFPSGKLSDSLKLGDAQGAVEGAEYAESARGKRCGHIFKPGEASYMCRTCGTDETCCLCSRCFDSTDHTGHMVRIQISVGNSGCCDCGDDEAWRTPLLCTIHSDMDKCLDKGKCREAAALPDDLVTNLQMTIGRVFDYICDVISCSPEQLRQAKTKSSIIHDERSSALSSQYYGSEPEPCGDFALILWNDEKHTVQEVQDQVARACRKEVREASNNAWETDTVGRSILTFSRDIDQLLQMSRIMEAIRVTVTIRSARDTFREQMCGTLVEWLSDISGCSVGHDNHILRQTVCEQVMLPWRQGSPAIHTMGVIDDEEEDEQSLTSTTRLHGLNARFLLALQAVAGNRADLEIAIGGGDDDDDDDDDDDDDEEEEDDEEEDEVDEDHAEEDEEDGDDDDEAVEDADMDDGDMENRSTSSSVAGRGQDEDEDVMMVDARGEVADLGMNWSQPDQALEEDEATMAGYPPPPPPPPPAQGRRDRDGTPSDSDTAEPLIAPAIYAKANVEIPKTPGKTERVTPRPGRYWIETPAIYTQRDNVPPAEDVFQRVRLDWLLLFDLRMWKKVRNDLRALYISTVVQIPEFKRVLALRFASLYTILAQLYLVGDREPDHSIINLSLQILTTPSITAEVVERGNFLSSLLAILYTFLTTRQVGHPWDVSPDAFLAFESGSVTNRRMYHFYQDLKYLFSSAHVQERVRSEPRYLMQFLDLVKLHQCIGPNVRAVAEHVEYEADTWITASLVTRQINLQARNLAEAFRDCPPDEVHYLQRAIRFTAKTVILNSIGAERHRFKQVEIKDDEVKFKTLSDFEFDAEGASYDVVRFVVEKDPISFHHALHYTLSWLIECGRSIPASSMRTLLAFTAQELRSKPRLMGRSQLSRRERSPEDYLMVAFDFPLRVCAWLAQIKANMWVRNGISLRHQAGTYRGVGQRDVCHHRDIFLLQTAMVVCNTNRVLASIIDRFGMDGWVKGLFELKSEAQDDIQHLDVVEDMIHLLIVLLSDRTSLIAPEDEPNSRMLAIRRDITHVLCFKPLSFNEICNKLPEKYQEQEDFHRFLDEMATFKPPEGVSDVGTFELRHEFIEDIDPYIAHYNKNQREESEMAYRKKMAKKTGKTVEEIVYEPKHRPIPSGLFEKLGDFTGTGLFAQIVFYSLLYPLVAQKFTPSVPSTRLETFLQVVLHLILVAILEDGTSEDGPAATTSNSFVFTALTKVARSNFMSEASSARTIVSLLNLLSTRDQFKSAHPKIALVLKRLKQKRPGAFEAAFAHLGIAVDRINTASPANNSAEEERERRKKAALSRQARVMAQFQQQQNQFLENQGAIDWGSDLEDEDEAQQTEDRKHSWKYPTGTCILCQEEADDRHLYGTFALLCESRILRQTDFQDADLVREASQTPCSLDRSAEDIRPFGIARENRKMVEKLSPQGEVFLAERQTIGKGYPGKLARPGPVASGCGHMMHFRCFEAYCDATNRRHEHQIARHHPEDTNRNEFVCPLCKALGNVFLPVIWKGLEESYPGHLQPQSSFADFLTKQMGAAHWHVGGKARQTEASGLPELHTPSTLGSLVEGLGKSRAADHPGRARQYLETQAPTMRMSASSLLEGSATATRHQPGSSSSSSSGAGGGLANYEMLGELLAAYRRLRDTIRKNNLSKRHALNVKPEDVDDLDVSDTLVHAVGFTISSVEIQQRGVEAQLGMTLLDKIPDQVLTHLRVLSETASAYVSVGTRRSGPGSRIESEFRRDSERQHCQLFITRSLDPGTSETLRLTEMYDPLLNLDPFLFLVECAYGLARAHQTDIFHLVRLCYLAEVVKVVHHMGRNIPQALWLGKLRNRQAQTQDAAIHNFACFALEVTQYGTNGDGATSVSRAEEGQNRGFQQPGVDSPEGWYTFVKKYALVFLRKSLVFLYVRYGVDFNSHISPSPDADELDRLTEALRLPNFDEMCASLTSKSRSCGWPDETRDMVSGWVAHQMLYPWRPGRACPSAVVVHPGIFELIGLPKTYDTLIDEATRRRCPTTGKDLTDPVICLFCGELLCSQSTCCQQPAVISSEPTRIGGAQRHIRRCQRNMGVFLNIRKCTAVYLFRQSGSFTPAPYIDKYGETDPQLRHGRQLFLNQKRYDTMIRNTVLNHGVPSLISRKLEADINNGGWDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0H7</accession>
    <name>A0A367L0H7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000023">
        <property type="protein sequence ID" value="RCI07907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0H7"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI07907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="121" mass="12793" checksum="1F3A225D2D44A7DF" modified="2018-11-07" version="1" fragment="single">MDSRGIRRLSVVTGLVRIRQIDVPMPRCIVMTVRPSFAPTIRVPSGPAAVLPLRLSFGPDGGVASASVTSLHMEEGEEEGECIMGGHTPIQQPKAFSDAGRGLKVTNDLSVTALLQSTIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0R2</accession>
    <name>A0A367L0R2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5688</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000024">
        <property type="protein sequence ID" value="RCI07802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0R2"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI07802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="86" mass="9261" checksum="D77541BA7CF20178" modified="2018-11-07" version="1" fragment="single">HRISPFCLDNGFNSARHQSHETKKEVFISSVPSLLDDAFKFLLSDPFLPAFYSLRGGSCGLSGSGSGCRLAKPLSRTGGMLWKGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0W1</accession>
    <name>A0A367L0W1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GPR/FUN34 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_7827</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000022">
        <property type="protein sequence ID" value="RCI08070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0W1"/>
    <dbReference type="STRING" id="1330021.A0A367L0W1"/>
    <dbReference type="OrthoDB" id="3648309at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015123">
        <property type="term" value="F:acetate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051633">
        <property type="entry name" value="AceTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000791">
        <property type="entry name" value="Gpr1/Fun34/SatP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047622">
        <property type="entry name" value="GPR1_FUN34_YAAH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF038013">
        <property type="entry name" value="AceTr_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31123:SF1">
        <property type="entry name" value="ACCUMULATION OF DYADS PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01184">
        <property type="entry name" value="Gpr1_Fun34_YaaH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01114">
        <property type="entry name" value="GPR1_FUN34_YAAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="73"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI08070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="287" mass="30880" checksum="842D2F6EFFADF5B7" modified="2018-11-07" version="1">MSTDNASRAASLEKEPPTVTPAGPGSSPGPILRHHHHHHNYSHMTASPGVATAGADGGAMQVGLWKPYEHRKLANPAPLGLSAFALTTFVLSAINMHARGVSQPNIVVSIAFAYGGLVQLLAGMWEVACGNTFGATAFSSYGGFWISYAIILTPSWGILSPDGPYHGNVASPIGFFLTGWFIFTTILLLCTLRSTVTLFLLFFFLDLAFLFLATEQYALDVGNKSLGLVLQKTGGAFGFVSAFLAWYNALAGMQDSSNSFFQVPVFHFPWSDKGRERRAVKDDRSEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0Y5</accession>
    <name>A0A367L0Y5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_6219</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0Y5"/>
    <dbReference type="STRING" id="1330021.A0A367L0Y5"/>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14008">
        <property type="entry name" value="STKc_LKB1_CaMKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000995">
        <property type="entry name" value="BcCMK3, calcium/calmodulin-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000447">
        <property type="entry name" value="Calcium/calmodulin dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF150">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE STK11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="91"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="444"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI08084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="661" mass="73424" checksum="E18197C964B8FAD8" modified="2018-11-07" version="1">MASSDQSRERSSFSSGIMASSSEPRITVDGCAAEAEGDHGASTPTRRFASPMRQHRRTASAHREIKETLDAHVDFTNDEADGQTYQQVNQYTITDEMGRGSFGSVHRAVDQFGKEFAVKEFSKSRLRKRAQSHLLRAGPHGLPRHVATHDGSLAPQLKGLRADERNDALFFIREEIAIMKKLDHPNLVQLIELLDDPEEDSLYMVLEMCNKGVVMNVGLDSGQSKPYNDETCRYWFRDLILGIEYLHSQGVIHRDIKPDNLLLSEDDVLKVSDFGVSEMFEKPGEMMTAKSAGSPAFLPPELCGAHREVSGTAADIWSMGVSLYCLKYGRLPFNRPSVLEIYEAIKEEDAKVPKDDEDANFVDLLHRILDKDPDSRITMAELRNHAWVTKDGTDPLLSAEENCAHQVEPPNELELNRAITRKMNHLLCVVKAIRKFKTQLAQIRQRARASEDGGGGGGGTEPSSPPSSAEPTTGREVIESIARRRRNLLIRVDGVQGEKNLGQGQYGDQPAERPRFLGIGTGASHYLTMEDDPTTKAEVDVVADSPTMVDYDIYERAYDDAVERQLRAAATTHPGRPTLYLNKFVQGAEHLTDVVKEAEHKIAHGVEHRVAKEAGDQLSKLDGLLVSKAGGTGQEIRHRLRHHLASKVGVLPEAEMRMSEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0Z8</accession>
    <name>A0A367L0Z8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6258</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0Z8"/>
    <dbReference type="OrthoDB" id="4838114at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="316"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="425" mass="44855" checksum="396E44D4E44C163D" modified="2018-11-07" version="1">MSPPVVGQRVDAIPDDHRPPYRLDAGPHCHMPPPSPAHNDHPSQLDLDEDAVLSVAQMDQQASSSSSSSSSSSSSSSSSSSSSSLTTSSSSPSSVDDGLSAGAVAIMATAPALPAKSARRASRLLASLSQKTAPEDRPILPHAAPHQVYLSSEEDASSSADDMSDLDELDWDAVTDSNKSPSSSSCCSREDTARVVTVVFHGRPSLVELVPRKSTGSTDEARPSPLMLRTATEPTLFRSRSNSSSAGADQTTLQYPPRSSSMTPSGFHMRRPQFLTIDPFAYNSHEDNPTRTPKTPSAMLKKTLSLVKKRSRPLLATATSSSSTFSSSSTSINAPLPPCTPPVAAASPTPETSLEQLGEEPEELGCGSKNNRESITYQGILRNARRNAEAAAAARAEVAAVSPPTPHRSRFRSGLSISRPRSVRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1S5</accession>
    <name>A0A367L1S5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">adenosine deaminase</fullName>
            <ecNumber evidence="4">3.5.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_8866</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>adenosine + H2O + H(+) = inosine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:24408"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:17596"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.4" evidence="4"/>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1S5"/>
    <dbReference type="STRING" id="1330021.A0A367L1S5"/>
    <dbReference type="OrthoDB" id="7202371at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000017">
        <property type="entry name" value="Adenosine deaminase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF39">
        <property type="entry name" value="ADENOSINE DEAMINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016817667" description="adenosine deaminase" evidence="10">
        <location>
            <begin position="18"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="domain" description="Adenosine deaminase" evidence="11">
        <location>
            <begin position="231"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI08393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="568" mass="63888" checksum="8C9E6E7742C60BB0" modified="2018-11-07" version="1">MLLLSVLFLGLAVSAVAGSWRPFPGADSAAVTEHMLARDAMVKSEESRRQDQEFRLRLSPVAVRADSIVRKIRQYEIQHFWAANDTRESFAGLMFPLARPYITKTRLWAIVRRMPKGALLHAHLTAMLPYRVLLEAVLHTPGMVVSASRSLDTDEARDGASIAFSHINTTTAAGNVAITSTDYVPGTPVFVQAAASSFPGGEQAFVRYAMSKLVISPEQATHHELGVDHIWRRFETLFGTAATLLSYEPIVRTFYRQLFARLVDDGVNWVEIRAGGVRKKLIRSGEQDADPDLDVWWEVMQDEIRRFKGTEKGKRFWGARVIWSDHRGRDRALLRQSMKMALERKVKFPQLFSGYDVVSQEDRGRSLADMTPELLWFQHEAAELNVSVPFFFHAGETLGDGNATDSNLFDALLLGTRRIGHGFSLYKHPKLIEFAVANRVMVEVCPISNEVLRLATDILHHPLPALVAHGVPTSISNDDPAMLGQDAAGLSFDFYQVIQAFDNIGLAGLGALARNSLRWSHFEDQSDAEWKRDIDLAEQGPGVKAMRLREWDRQWDEYCHWVVTEYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1T5</accession>
    <name>A0A367L1T5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPN-loop GTPase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_8959</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1T5"/>
    <dbReference type="STRING" id="1330021.A0A367L1T5"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF3">
        <property type="entry name" value="GPN-LOOP GTPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="260"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI08403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="305" mass="34108" checksum="692057DED87FFA7B" modified="2018-11-07" version="1">MPFAQLVLGSPGSGKSTYCDGMHQFMGAIGRASSVVNLDPANLQTNYPCALDIRDLVKLEHVMREDRLGPNGGILYALEELEHNFEWLRDGLAEFIGDYVLFDCPGQFVCVHLSDSICVTQPSLYISNVLLSLRAMLQMDMPHVNVLSKIDKVSSYDALPMNLDFYTDVDDLSYLTPYLEAESPVMRSEKFGRLNEAIANMIESYGLVRYVALAVENKQSMTQLLRIIDRAGGYVFGSAEGANDTIWAVAMRNEASMMEVQDIQERWIDQKDEYDRLEREADEAQAMELELSQAAAPSSGEMDRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1W6</accession>
    <name>A0A367L1W6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SRP54-type proteins GTP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_8904</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1W6"/>
    <dbReference type="STRING" id="1330021.A0A367L1W6"/>
    <dbReference type="OrthoDB" id="347435at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI08430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="32376" checksum="ABB95708DF2550EC" modified="2018-11-07" version="1">MDDKSSVCLPFLLELLDAHPSPQPLIVGLNGLQGVGKTTLAAALVASLEARGIAAVACSIDDFYLRREDQVALAHRHADNALLQHRGEPGDMSLCAAPLARAVFASLARGLPTKIPRYDKAAYNGRGDRLPESCWRPVNQPDQAPVRVVILEGWCVGFRALSNSDVEARWRAPSRTLLNHRLEHLLLVNDMLRSYDGLTDLLDVMIHVDAEHIECVYTWRQQQEDALRVERRDPNAGMTPDQVLDFVDGYFPAYELYTQGIRSGVLPDRPGCQLRLVVDRDRNVKQVLRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1Y0</accession>
    <name>A0A367L1Y0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_8977</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1Y0"/>
    <dbReference type="STRING" id="1330021.A0A367L1Y0"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12432">
        <property type="entry name" value="RRM_ACINU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034257">
        <property type="entry name" value="Acinus_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47031">
        <property type="entry name" value="SAP DNA-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47031:SF3">
        <property type="entry name" value="SAP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="5"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="586"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="626"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI08416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="678" mass="74682" checksum="E2217F8EE22185C5" modified="2018-11-07" version="1">MSSDWTKLKVTELKAELKNRGLPQGGLKAELVARLRAADEEAAPSPGKDQFVEPEAVDEASDEPIELVPEPSLHGEGEEEENDGGGDDGVNVKPAIAEVVQQPPPVPSPTSRSPPGPPTEADGAAQESRNGEHVVEATLPLEGATDALKRKRRSASPPPQEESVKRRRSEEEEKDLEEEEDLEEEKDAKTWPRMGAGQDQDQAQPEKPDTAEVMQSERPKSMINLAVPTTQEPEHDEEESSPPSGPVDPPTHPCTSAIYINNLMRPLREADLRAHLVHLAKVSADNKEGCEDDVVMERFFVDAIRTHAFVVFGSTSTAARVRNCLHGRVWPRESNRKALFVDFVPADKIGPWIEMEEEHMGDRKTSVRWEISYRVTDDDEVEATLRPNAAIAHVGSRNSVPAAPVGVEGAPTGPRGYRSSAAPPAPRDYHGHMAGPDAAGYDDFRRGPSPPLPPPPPRAQGGPDDGGGELTITQPFISYRTVPVVLARRRLHNLRGLYTRDLGRPLGREINRYSFQDDDHFVDRGKEVFEGIRPPRRQHAIDRERMAANSANGPPPRGIYRGGGNRFFSSQGGGGGGGGGGGGGMAPPPPPPPPPPPSYGHGSRGDRHYHSGPAFDDDDGDYYRDRSRHYHHHQQQQHHHHHHHDHREHQHQPQYDRQPRYGHSHGGGPEDGFDNRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2A2</accession>
    <name>A0A367L2A2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_8834</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2A2"/>
    <dbReference type="STRING" id="1330021.A0A367L2A2"/>
    <dbReference type="OrthoDB" id="3445164at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="9"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI08560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="272" mass="30865" checksum="BE6337107B55779C" modified="2018-11-07" version="1">MVRFLAEAAALSPQKAGGYDSGGPELALKRGLMRAPTRRGRSMTTDSGDEQHQQRRIVDRQASIPEDGLPNNYHHPAPSRPRLPPPRRSYSATDKEPEPTSCSQWRTTTTTTTTTTTKMTLLDLPSEVLYQLFDHLDPLDGVCFGLAHPRLYAIQRRKHGTVSLDSRYAGPNDMEWAWRGAGPPLLRRSSWLRGQVYCRKCGVSRCELHRHLKGWMGEGYEYCEIRRMFGRPAGGDARSYCFMSSPKKPDRCGRHHVDVKRGVKEKPDFVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2P5</accession>
    <name>A0A367L2P5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Fumarylacetoacetase</fullName>
            <ecNumber evidence="3 13">3.7.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Fumarylacetoacetate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L249_4626</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10244"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18034"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="3.7.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.2" evidence="3 13"/>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2P5"/>
    <dbReference type="STRING" id="1330021.A0A367L2P5"/>
    <dbReference type="OrthoDB" id="9971669at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004334">
        <property type="term" value="F:fumarylacetoacetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902000">
        <property type="term" value="P:homogentisate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000009">
        <property type="entry name" value="Fumarylacetoacetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.230">
        <property type="entry name" value="Fumarylacetoacetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005959">
        <property type="entry name" value="Fumarylacetoacetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015377">
        <property type="entry name" value="Fumarylacetoacetase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036462">
        <property type="entry name" value="Fumarylacetoacetase_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01266">
        <property type="entry name" value="fum_ac_acetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069:SF2">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09298">
        <property type="entry name" value="FAA_hydrolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63433">
        <property type="entry name" value="Fumarylacetoacetate hydrolase, FAH, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Fumarylacetoacetase N-terminal" evidence="16">
        <location>
            <begin position="16"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="15">
        <location>
            <begin position="133"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="141"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="376"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU366008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF09298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCI08694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="445" mass="48333" checksum="791F95FC8137FCCD" modified="2018-11-07" version="1">MSWLPIPRDSHFSLSNIPFGIISTAKDPSPRPAIAIGDHVLDLRAFTSADGFSAAPPELRDDPLLRTVLAEASTLNPFAARGRHFHRLVRRYLQHVLASDTTVLRDDEPLRRAALLSRAEVRNHLPMTVGDYTDFYAGKHHAFNVGSLFRGPAAALQPNYLHLPVAYHGRASSVVVSGTPVRRPWGQILEDPAAEPKMPALSPSQRLDLELEMGMFVCGENELGRPVPVDEADDYIFGYVLVNDWSARDLQAWEYIPLGPFTSKNLATSISPWVVLADALADAKGPGIANDTPLLPYLREKVPDQVLQVELEVDLTTAAAADMGTDSDVEKAAEGDTTTISRSNSRFLLWSWPQMMAHHTISGCNLRPGDLFGSGTISGEDPASTGSLLERTGGGKTAMRLQGGGERRFLLDGDTVVIRGWAGKEGARVGFGEVSGKILPAEQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2T3</accession>
    <name>A0A367L2T3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_4747</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367L2T3"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF29">
        <property type="entry name" value="ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="9">
        <location>
            <begin position="2"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="10">
        <location>
            <begin position="925"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="2239"/>
            <end position="2313"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="6">
        <location>
            <begin position="925"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="6">
        <location>
            <begin position="1074"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1335"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1889"/>
            <end position="1912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2199"/>
            <end position="2224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1339"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1889"/>
            <end position="1900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="2199"/>
            <end position="2218"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="6">
        <location>
            <position position="957"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="6">
        <location>
            <position position="1139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI08739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="2315" mass="250485" checksum="168014EA59906D0E" modified="2018-11-07" version="1">MDDDIAVVGIGLRFPGDASSPEELWKVLERGESQWSEFPQDRLNIDGYYHPSGDRQGSISFRGAHFLKGDIAAFDSPFFFIAAEDAKAIDPQQRMLLEVSYEALENAGFRKEDLDGSDTAVYVGSFVKDYEQICLRDPDWQPRYAATGNGIAIMANRISHFFNFHGPSMTIDTGCSGSLVSVHLAVQSLQSHESSLALAAGSGLILTPNTIMPMTALNFLSPDGKCFTFDERANGYGRGEGIGVVVMKRLSDAIRDNDTIRAVIRASSVNQDGRTPGITLPSKEAQVANIRAAYASAGLSFEQTAYVECHGTGTQAGDWRELRAVSETLGSVRGKGNPVVVGSIKPNIGHLEGAAGVAGIIKSVLMLERAKIPPNINFERGNTGIDFEEWKVTVPTTVMEWPKKDGIRRVSVNCFGFGGTNAHVILDEAPGYLAARGMFGQHSSVVDRMRAVSGRQVEAHQSELLFCYSSHEKSGVGRIVESHLDFLESRERTGSAICLRDYAYTLGCRRSALEWRGFVVANKREDVASKAEQMIREGVVRAGGRDQTPRIGFIFCGQGSQWAQMGKDLLVFEAFRCGICDASRYMALALGACFNLTEELLRTDRDSRINQVMLAQPATTAVQVALVDLLASIGIHPRQVVGHSSGEIAAAYAAGALTREQAWEVAYYRGMAAASLGERAPKLRGAMMAVGLSEREAEAYLAGQSAQVACINSPKSVTVSGQASTISSLERTLRARGVFCRVLNVGVAYHSSHMRLVEHDYRDALAGLEASSCEPSIRMFSSVTGAAVDGSELEASYWAANMVSPVRYATALEAMMRDEDGPDLLIEVSPRPSLRSPTLDVLAGSNGDDQRTEYRPVMEKGGTAGPLLRLVGELWTRGCALDMEPLTARAKCLSDLPPYRWNHGRRYWHESHLSLANRFRAYGRRDLIGAPTADSTPMEPRWRGFIRVSENPWIQDHQVQKTMVYPASGMVSMVLEAASQTRPDVFGYEVVNTRIEKAMVIPNSTHGLEVALNMKMGDDDDDAPASFSIYSKPLGREWERNASGGLYFRTRPHVWAAVFSAHDDRLEALDERCDGPVDTRQLYEALDTVGINYGPLFRNVVEVRRGEASVVGRVRVPDTRSKMPAKFEYPHVLHPATLDGMFQTLFAVDSSPMVPTFIRSVFVSVGSSSSSSSSSSSCFTGYATVERAGVRGAEATIAMRRDDDDDDDDTRVIVDGLLLTALSSPADGGFLPNHRGLCSEIVWDEDSASASPAQYADLVALLAHKFPALAVLQCGGGFMAARETLTAVMGGEVEGGRDETPRLARYTLLERRGEEVDKILDWAGHTPLRPLIEVRPRVDDDDDEEEDEEDEEDEEISTHLYHVIVVFADADVDVNKLRKQLRPGGVFLSQHRRDGQANGNVDQIAFGAVALDVYRQPAAARAEMDIVLLLPDEPSAEARAFTETFKQLTGTVVVVSAAEVERDKASRSLAGKVVISLVDFSLKEDGEACSVFEWNKSDFDVFNAVQTSARGILWITRSAHMKPTNPKGAPIVALARTLMSEDPLKTIVSLDVGFETRLGSSSLSRNVLDILGRTWQQKPDDANPLEMEYGEEDGRLYIPRLRPLASLNRLLLLHENDDDGGGGGGKLIQRPFSYDECPRELRLVLARPGLGEGAQYWTECGDCCCDEELRPDEVEVEVTEVPLTHLDLETVMGRSCETVLGMDAVGRAGASAHGLAAVKVARRIGADDVFVSIFGPDAERQRESLRRCGVEDGSMVDVVDESCLVAFVRARTGWKGVDVVFNPTGEHIGAGFRCVRRGGTVVQFADGCWRTLPSIQGPAATVVSHHLGQLMRDDPTLVAEMLESVVRLVGDEDGEEADSLDIDRVPDALGRLQAAPYSGPVRLVVNGRESRVKAAQARDEKKKKKKKTRSDSIAAEAIDPNATYLVVGGLGGLGRSIADLLVSSGARHLALLSRSAASSASSASSSASSWLAGLRSRGVNGRALAADICDADQLSSALDTIATQMPPIRGVFHCAAVVRDAVFHNMVFSDWTEATRPKTKGTLNLVRAVPEEAFFVFLASAAGVIGSRGQANYAAGNGFQDAMARSLRLGSRRRRAVSIDLGPVLGAGMLAGSDPSTLTTLRASGFYAIRHQDFLRIVAYALSSLDLVPAQIVVGVGTGGLMRQNRPADPYWCRTALYQHMNLVDVPSTDLLLLSSSSSSSSSSSSSLSSSSSPSSSSNARGRTTTNLSHCVDVSSAAEVVCTALVSMLAQAMTMLPDELDANRPPSAYAVDSLVAVGVRSFILATFAVEVSVFDVLGDGTIAELARGVAERARC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2X5</accession>
    <name>A0A367L2X5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_4805</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2X5"/>
    <dbReference type="OrthoDB" id="3437016at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF191">
        <property type="entry name" value="VACUOLAR BASIC AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="379"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="411"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="442"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="515"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="56"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI08783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="550" mass="58964" checksum="74E853F604AA1CE2" modified="2018-11-07" version="1">MAIRPPKTLHTMPRNNSNDDTATTALLLPPKHDDDDDDDERTVIAKQVSFTKLALIMTTAWSGVFLSALDSTIIATLSAPIASEFRSLSLFSWLATGYFIATAACQPLSGRLTDIFGRGPGLVFCNVVFAGGNLVCGLASNQYVMIVGRVVAGVGGGGLLSIATFVASDLVPLRQRGLVGGIGNLWFGTGCMLGGVLGGLLNDYTSLGWRLAFLIQVPPSILSAMAVPLLVQVPPKQSDRSHLARIDFLGVFLTSSFLLLLVFGLNAGGNLTPWAHPLPISCLLLSLVLFITFLWWESRARQPMLPVKLLLHRTVFFASITSLLVAMLANTAIFYVPLYLQMIMGETATSAGLRTLSSPVGMVCGALCGGYLMRRTGKFVGLAIASVVMLVVGAFLLCLQSRHTPAALTTAAFFFIGGGYSAVLSTTQIACIAAVDHSQQAVVTSITFLARSLGSTAGITIVSALYQNTLDTQLWSRFRHEPDAAAIISRLRDDITQLRNVPPAWRSGVVASFSAAFRCVWLTVFAWALLALVFVSLIKQHKLHSSLDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2X8</accession>
    <name>A0A367L2X8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">EXPERA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_4897</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2X8"/>
    <dbReference type="STRING" id="1330021.A0A367L2X8"/>
    <dbReference type="OrthoDB" id="5415655at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047750">
        <property type="term" value="F:cholestenol delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007905">
        <property type="entry name" value="EBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207:SF1">
        <property type="entry name" value="EMOPAMIL-BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207">
        <property type="entry name" value="STEROL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="15"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="8">
        <location>
            <begin position="43"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI08774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="248" mass="27302" checksum="68353DCC3AFC7A05" modified="2018-11-07" version="1">MEATTPPDLLDRTTLLSLLSTVAMAATAYWTSRRAVSASTSTSVRFLFAWHMADALCHFILEGSFLYHCFFSARKVSSFEGGGGGIFFPTAENFLGYGSARGDGDGMGVVVGPQAGGGNPFALLWMVYARADRRWAGADLGVVSLELLTVFVDGPLACYVCYLLSKGDPRASFWMVVLATCELYGGFMTFCPEWLTGNLNLDGSNFMYMWVYLVFFNMLWVFIPVYAIWYSFTDICNAFAVRAAKKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L422</accession>
    <name>A0A367L422_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dystroglycan-type cadherin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_1504</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L422"/>
    <dbReference type="STRING" id="1330021.A0A367L422"/>
    <dbReference type="OrthoDB" id="41532at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006644">
        <property type="entry name" value="Cadg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05345">
        <property type="entry name" value="He_PIG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00736">
        <property type="entry name" value="CADG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="455"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Dystroglycan-type cadherin-like" evidence="3">
        <location>
            <begin position="107"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="535"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="646"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="709"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="428"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="665"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="723"/>
            <end position="744"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI09167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="801" mass="85827" checksum="88E00E0EE643A9D2" modified="2018-11-07" version="1">MERDLLSICLLPPVARIGKFFSYAVSSLTFTSLDSNHISYALGEHPDWLSLGTDGSSLYGTPRDTSVPRGRVVGQPLEIIASDGKGTTTMKATVVVSRNPPPSIAIPLADQIADFGDISAPSSVLSYPDTSFKFSFDRNTFGGEPLNHYATSGDGSPLPAWVSFDNGSMTFSGKTPPFKSLVQPPQAFDLRLVASDIVGFAAVSIDFSIIVGSHNLTADQPMVSLRASWGSKLLYDGFEHGIRLDDKPISPSDLSITTKRLPPWLTIDPTTGKLEGTPGPGDHSTSFTVSFHDPFSDTLDVEVTVQVDTSLFETTVEDMEARPDSRIDVDLAKNLRHPDEIEVELTTSPEQDWLRVHGLRISGHVPKSAKGDFQVSIRAKSKKSGLQETEKFGVAVLALDGSTTVPVGPTAPSTPTGTQHNANPTSPPTTTTTTTTTTANGGAESEPNRLSTGEIMLATIIPVIFISVLLMLLVCCVRRRRARQAYMSGGKGGKDMISHPMAISHDPTDSDSTTIDNTAVIGGARAEKLQHYKPTRGAGVVKKPAPRRRSSDTLGPGDESDSGFSAGTEAYDGRRSMTARSVDSAERDRRSWITIEGDDAASIAPGSAGSHMSDTTFSESTHQLLPAVDSLHEPIVHDFRSGLDMTIPTMEPDQPTPLNIYKRSGQPSTRQSVGAHSIQTSSSVALPSTLGRNWGTQRSMSNWETIAESDVGDSASEAAAPPRRPDRALMGDDLRRRQWYDDSPRIGGGGVDDDRGTDDSFSSSENWRVIGPRTGRQSMSGTLAGGEDDDDDGDGSFKVFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L430</accession>
    <name>A0A367L430_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1484</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L430"/>
    <dbReference type="OrthoDB" id="5143322at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="534"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="590" mass="64019" checksum="2F2FD9C38527B65D" modified="2018-11-07" version="1">MSSAAVDDDQIRRAMLDDLGRSRLDILPLSNRECNGSSFRPSRDGGERKFAQEFRVQLKSKWNNVSFEDEEARQMEGLANDDARPWAKKAIDIPVKSAPPRPAKSQAQPIKKQASPPAKKQAQPAKPQPKTKPAKTQPAKPQSVKVQPVKAQAAKTQPSTIQPSKASSNNPPPAKTLPSEAQSRKVRRSKARRSKSSKKAKQKQSEPEAAQSTNSNEDVLCSGICYLPTSNGASEIRVVYALLIDINADSAFLALTLPGSERKVHNVIDLETTIQHDDTCVVTARPGKGSYRYCLRLDERGRNVQLKRYLDALRKHADYVPPQQVADVRPPQQAEVQSSALMDLIDLEISPPATSELPNEVCGSASTVTDAADQLSEFLQRISRELGGCGPGSCEDKAQELEQRATDFWANMGFTESEAEDLLASLRALTRVQKKVRLRQTANSRAGDAACEVSSTIRYSATELESLVGRAAPCPRVRDIVGFGASGTLPTMPANASREKSGLPSMSKCREWLLRSPSESKNPSDAKEAVAWPDHVDPMEIGAVQPVSSTMDVTGKSDTTSEPVLPAAPTSRLTSPVGGPGLETSRWASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L476</accession>
    <name>A0A367L476_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_1534</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L476"/>
    <dbReference type="OrthoDB" id="4927092at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016950450" evidence="2">
        <location>
            <begin position="18"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI09243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="252" mass="28380" checksum="BF734C94C0D2A0A5" modified="2018-11-07" version="1">MRATLAILAALAGTAIATPVAEPTSFIKPQVLDKCPPHLSCMEFCQDKEFVSSDRKVDFGSCFVADDKVYCSQYNATNNEKMRSRHFDCTSENLVDAANNQASLGSSAHNVSDHGLSRPARSVENSVRDHATNERPPEDRERQKRAIEEIEARFKSSVDDHIKGLGAPCDKKTGMCDVRINASVLRDIMKNCDDKVGVFGYQKCFLDPKDMKKKKKKKNKKKKMMLEEKKKKKKMLEEKKEEEVPTEDGMSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L479</accession>
    <name>A0A367L479_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1396</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L479"/>
    <dbReference type="OrthoDB" id="529367at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="71" mass="7899" checksum="D3C2B500EAAEECA3" modified="2018-11-07" version="1">MDYAMFGIYFWCAEMIALYHLMLSHSHRVLTTGTVTGILLSNPVLKTSRWRESQGSPVVPNTMPPTGPSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4U0</accession>
    <name>A0A367L4U0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Carbon catabolite repressor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L249_3712</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Involved in carbon catabolite repression. Represses the transcription of a number of genes by binding to a GC-rich region in their promoter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the creA/MIG C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000015">
        <property type="protein sequence ID" value="RCI09440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4U0"/>
    <dbReference type="STRING" id="1330021.A0A367L4U0"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000433">
        <property type="term" value="P:carbon catabolite repression of transcription from RNA polymerase II promoter by glucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043609">
        <property type="term" value="P:regulation of carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000089">
        <property type="entry name" value="DNA-binding protein creA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000152">
        <property type="entry name" value="DNA-binding protein creA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051007">
        <property type="entry name" value="creA/MIG_C2H2-ZnF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47428:SF1">
        <property type="entry name" value="REGULATORY PROTEIN MIG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="76"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="67"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="206"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="387"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="107"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="271"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="393"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="403"/>
            <end position="412"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00077756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCI09440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="412" mass="44860" checksum="90509D1D2596DC38" modified="2018-11-07" version="1">MPSATTFDFSNLLQDKTTMASAVLKPNGPLPGSQPPSSEQSTELPRPYKCPLCDKAFHRLEHQTRHIRTHTGEKPHACQFPGCSKKFSRSDELTRHSRIHSNPNSRRGNKGQHHHHHHHHHHHQPPPPPHHHHHHHQGLPPHMHPEAMMGPPSAPKTIRSAPPSALGSPNVSPPHSYSSFAHHAPMPGHGYGSALAKAISQANGESLTAPPTHLAPHHHAHHHGTRPHPYHGVRSHPAGLSSYHMMRSHSTEDHHDDHYNGSLRHAKRSRPNSPNSTAPSSPTFSHDSLSPTPDHTPIATPAHSPRLRPYGGYELPSLRNLTLQHNTTPALAPMEPHLDAPSFPPTLGKPTRATGMSLTDILSRTDGSQRKLPIPVHKVTVQDLLSDGGGLTSSGRSSATGSLAGGDLGERY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4U2</accession>
    <name>A0A367L4U2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_3663</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000015">
        <property type="protein sequence ID" value="RCI09431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4U2"/>
    <dbReference type="STRING" id="1330021.A0A367L4U2"/>
    <dbReference type="OrthoDB" id="10249309at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1070">
        <property type="entry name" value="Translation initiation factor eIF-2B, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051501">
        <property type="entry name" value="eIF2B_alpha/beta/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042528">
        <property type="entry name" value="elF-2B_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI09431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="345" mass="37541" checksum="3BC49F7E625F5CB0" modified="2018-11-07" version="1">MTPIGPAAAGEASDLPIRRPSTPSANFDIVSTYRNLLASDPDLTKPVAAIESLILLLNNVPSKTVYETVDTVKHHSEKLKASVANPVPLTAGTDLFLQYLVSSLKQQQQQQGQGQDDGRSSFEAVRQHLLRNGRLFASRAVAARSRVAESGWRFVGDGKSVLTHGASRSVACLLARAARSRPGRFKVVYVHSETRLRESDRVVAGLRDLAIPVAEIPESAVAHVMGLLRSVDMVFVGAEAVTQNGGIISRMGTFQIAQLASRAGIPFYVAVETHKFSRKFPLDQRDIGFHQDMLHFTTDGPSRRTDDAVDYTPPELITNLVTEDGVHLPGYAFEQLLDIYGSLNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4Z7</accession>
    <name>A0A367L4Z7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1479</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4Z7"/>
    <dbReference type="STRING" id="1330021.A0A367L4Z7"/>
    <dbReference type="OrthoDB" id="5355007at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="177" mass="18521" checksum="E60F80324CD560B3" modified="2018-11-07" version="1">MAQQSSPTPSTPVKVSSSAANYSAATMEPDLRSQVNDALLRDGHITRIHEALLHALHSDPSNWPTAIQSRALSLMRSGQAPTFPKLLQRVIQEVRESTKPPPPSATATAATASASNNSSSSSNSVALNGETKTANGGGGNTPAPELCLALPESVVEEALRVTMECLDAICEMECPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L598</accession>
    <name>A0A367L598_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L598"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="121" mass="13072" checksum="FE08E5792935775D" modified="2018-11-07" version="1" fragment="single">ERTWVHRVVVFASDGVQVEIQRKHSANDGSYYLRTARGLDETGEMDSVASEDDPLGNKGMIKAMPHPAVHAVDGTSSDQRKKRTARHPALASFGTSAGSSSSRTEPSSRLQPHVCGQSRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5C9</accession>
    <name>A0A367L5C9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4167</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5C9"/>
    <dbReference type="OrthoDB" id="4941431at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017033546" evidence="1">
        <location>
            <begin position="19"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="162" mass="17061" checksum="37E1BD9D35478248" modified="2018-11-07" version="1">MKVWSFVITAFASTLALAAPTSSSSSTNSLEPRSSFDASGLNGLVFNQRDLNYLQSINSFNLNAFQQLSLNNQLNLAVFSNVFGGNVFDINALLALQTMNTLVQVANVVPFGNVNLAGVQFAPLELASLGSIGGVGLGQFVDERQLGVIQGVVSQIPAPVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5G3</accession>
    <name>A0A367L5G3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial K+-H+ exchange-related-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_3826</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5G3"/>
    <dbReference type="STRING" id="1330021.A0A367L5G3"/>
    <dbReference type="OrthoDB" id="5562676at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902600">
        <property type="term" value="P:proton transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018786">
        <property type="entry name" value="Mit_KHE1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28062">
        <property type="entry name" value="K+-H+ EXCHANGE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28062:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10173">
        <property type="entry name" value="Mit_KHE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI09670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="32075" checksum="37A918C04232F668" modified="2018-11-07" version="1">MRIFLLPVSTRRSLLYAQRLEPSPSTGSDKASPRPRLVDRGAAWAAAKWAQWEKKPAGWQRRVVDYGNQALRRIPFEEWGLRSVPPLSVRRSREEGQAGTDGVELVFPGGAFGPDEARSMVLRLATERLGLHRQRFIWCFAAMPLTLPFALVPIIPNLPFFYLVYRAWSHWRAIAGGRHVQWLVENKLLRSAPSAKLSQLYASGRPPTRNNDQETMLLTQNQVRSFCDALAAPALEVELERAVWQVRKALEERRSEAEMQPNAGQRSSKPQGSIVRERDKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5G4</accession>
    <name>A0A367L5G4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3809</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5G4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="209" mass="23171" checksum="D7AAED28831E1831" modified="2018-11-07" version="1">MSISLVYLVPPSLQRRKSKRPDLIEMIENKTRENAQDVSHSRWTELLRHLLTESPMLARLAVLDAPGTTSGARDAQLLVSRVHVSLCQAVSLALAAVTPPFGQLRVVPASTTGPSSHLLLLRRATETRAGAGSKLRPQGISPSSSSCPPWHWRKRSTRTFPRKKKDESEEGEGAYSWPKAAPYPPRRLLHQKTVINQSARAEMARLEGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5G7</accession>
    <name>A0A367L5G7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_3844</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent RNA polymerase which catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5G7"/>
    <dbReference type="STRING" id="1330021.A0A367L5G7"/>
    <dbReference type="OrthoDB" id="10256606at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04330">
        <property type="entry name" value="RNAP_III_Rpc25_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000221">
        <property type="entry name" value="DNA-directed RNA polymerase III subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013238">
        <property type="entry name" value="RNA_pol_III_Rbc25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08292">
        <property type="entry name" value="RNA_pol_Rbc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb7-like N-terminal" evidence="7">
        <location>
            <begin position="8"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase III subunit Rpc25" evidence="8">
        <location>
            <begin position="83"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI09673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="192" mass="22005" checksum="096D1F5C098C242E" modified="2018-11-07" version="1">MFILTKITDLVQIAPEDFSKHSIVAIEDNINAKYSNKVIQKIGLCICLYDLLWASEGLIGHGTGLVNVNVEFRIIVFRPFKGEVMLGRIRSSTPAGINLRTDFFDDIFVPYKELPPGAEYNHSEQLWIWNLEGTHMFYDKNEMVRFQVIDEEWHDQTPVGPTQSEDVPAKTPYKIKGTMAYDGLGCCLWWDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5T3</accession>
    <name>A0A367L5T3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_4159</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5T3"/>
    <dbReference type="STRING" id="1330021.A0A367L5T3"/>
    <dbReference type="OrthoDB" id="4505928at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42070">
        <property type="entry name" value="FILAMENT ASSOCIATED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G06630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42070:SF1">
        <property type="entry name" value="FILAMENT ASSOCIATED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G06630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="116"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="186"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="20"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="129"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI09790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="26863" checksum="8164F0AEE27B00E0" modified="2018-11-07" version="1">MSTPAKDNLARIRDNQRRSRARRREYLQELEQRLRVYELQGIEASTEVQMAARRVAEENRQLRELLNRHGVDDNHIALYLQSGLVVSPGAGAVQQPFRSDPGSTVPALQHVMVPRPVAGLDPGLGAGGPSSLPGRSSREPSSASGSTATSSIWSPTQQQQQQQQQQQPAMSSYNRQHVNSVMGSHHTAFQPNASFGPGGRQDVFAESSSSMVSNPPAGRPPIELHYPLSAYQDPTGQQHYGHPGSGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L626</accession>
    <name>A0A367L626_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_3988</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L626"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI09886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="181" mass="20869" checksum="CFB9DBC7DB4C8665" modified="2018-11-07" version="1">MSLMERVFLPQRQLMNLFFIKVILILTLLSHKWPLLTASAALYRRLAVSRFLSIIASHRNFVRLSRLPRPCLPSTTLGGSLSLLLRLENYFSGALEVSNDHWIVRIVRQAVSVRVVVRCARLPNHRCILASNSRTHINVDEVNYKIVVGVRRAVERMNLSFFEDDVDAEFGKNVLQCRKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L661</accession>
    <name>A0A367L661_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF3328 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_8399</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI09913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L661"/>
    <dbReference type="STRING" id="1330021.A0A367L661"/>
    <dbReference type="OrthoDB" id="4906116at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF7">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI09913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="31283" checksum="9606BCC2F079A979" modified="2018-11-07" version="1">MMPQFRDKHQTSEQDTISEEQLQLNFQPKKRKGRCSPIARQVTLHLFIVAIYLTAFFAFWDYKGCGCRSRHKTGLLAYSPAWEALKWEARVLENEIEIKSPFKGLPRPELDEAWNKLLAPTAVRVSKEDLERINRTSVPLQDGSGYMAGLDVYHQRYVRRYLHKDYYNMTQEKNMGQHIDHCLDSLRQYIMCNADLSIQTFDWIPNFHRPWPNFRIVHECANWEAIEEWAWAHHFDGFDPSLLRHPNFHPELPGPFDYSESGNDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6I1</accession>
    <name>A0A367L6I1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6I1"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="516" mass="56635" checksum="F34DE63C6046E38F" modified="2018-11-07" version="1">MASGQPDLGDGMYHRHSRISDIGLEIYFLSFTSLFFFSLFSLLPLQHISKMKSTATVVTIASAGLASSTLAATLQPRACGLSRGSITMLSRHDLHAEDGCIGAGGKYRYDDEHLDQGAELHDAGDLVGNENEMLKISTTMLKKRRRCKEQLSKSEGSSLLQSRQVLTKAARRSSSLVYTPSFLWKRSSRFPSLSLSWNTMKLSSVLALAATAVAAPSEANRFCCDNDFYVLGSYSKGYDSCDGGSWVCCDGGSYSVSCDLPPPRTARLTSMCLLKGNYLDYYGGNCYPDYYKRRSRCMSIFCKNLHIKVQLGIFLGHFYFALTPSRMCYDPSAAGSPFLVSPWHKSSLVYVLCFLSASSSWSRLLSTTKTMKIGLVTACLALLGYRVMAVPRADVAVVESYNNESVVANKTIESRGLFLAGTLSLTVGGAIGGLLVDVISSICAEDDLSSDAAAMIVDKDGIRVYEKETNNYIQIGQDQRLAFDLIMEMLAKPRRETFWAAIQGHWLGEFSVEEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6L0</accession>
    <name>A0A367L6L0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mannosyltransferase</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_8414</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyltransferase 22 family. PIGZ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6L0"/>
    <dbReference type="STRING" id="1330021.A0A367L6L0"/>
    <dbReference type="OrthoDB" id="10066429at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF3">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016645780" description="Mannosyltransferase" evidence="12">
        <location>
            <begin position="18"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI10063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="522" mass="60076" checksum="2D9D1D73F4C50BDB" modified="2018-11-07" version="1">MWRRTYLFLVFVRLWFALSPSYLHPDENFQGPEIIAGEIFSYPIRRTWEFTSDHPIRSVFPLWPVYGLPMMLLRWLWIGNGQDGEIPPIVVFWTLRILMFLISFVLEDWALHELIPSPRHRRVAVLLVASSYVTWTYQTHTFSNSVETLVVAWSLVLIQRIVDSRHKSSLLSSAVLGLVVVFGLFNRITFPAFLLIPSLRLIPHFLNNPLSLLALTSVFLVTTAVAVALDTSFYTPETLTWAQLITKPVITPLNNFWYNSSTDNLAQHGLHPWHQHLLANIPQLLGPAAILLFTQPHLSIRLYSAISGLAMLSMFQHQEARFLLPTVPLILSSVRLPRNKLVLRVWVVLWVAFNLIMGVLMGTYHQGGIIPGQVFMSNQPDATHAFWWKTYTPPIWLLDGKNNVMQTRDVMGIDGETLFGQLTDLATCDAPADRRNKEYLKEKNGTYLIAPASADWLDQYLPNRGVQGLRFREVWRHRRHLNLDDLDFTHGIWETLSRVVGRRGLVAWRVTKSCQRIDMQNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6M6</accession>
    <name>A0A367L6M6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_8712</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6M6"/>
    <dbReference type="OrthoDB" id="10294209at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI10059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="117" mass="13149" checksum="A38C245A58E1C585" modified="2018-11-07" version="1">MAVFMKEKTVVAAEKSRHGPDDPRLNASLDAVGIGVVQLVVTDHGRYGGEIDEIGSPQKNEHILGDAAPRRVADTEEGRLCRDGWEDCQRQREAAWKTYRRCSRREIYSRIVPCLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6S6</accession>
    <name>A0A367L6S6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_8608</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6S6"/>
    <dbReference type="STRING" id="1330021.A0A367L6S6"/>
    <dbReference type="OrthoDB" id="360327at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF2">
        <property type="entry name" value="SPLICING FACTOR YJU2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="242"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI10127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="382" mass="42315" checksum="50C6A2585D181160" modified="2018-11-07" version="1">MQGFNMGRYMPPDQEASSSSSHCKKKKKTSGKDGSSCPPPPPTVRFEMPFAVWCGSCPKPTLIGQGVRFNAEKTRVGSYLTTPLWSFRFRHADCGGSLEIRTDPRNTAYVVASGGTKRSVHDAPSEHDLLRDEKRSNAFSALERTIEHRHQLRRADERIHGLLHSSARYWNDPYAQNQRLRDAFRPGRLRRQQDAASADRIRNAMSLELDILPAHQDDARLASLVSFNRDDDDADALEKPLFTPAVAPKRPVNHSASASSSSSSSSSSTTTTTKNNKNNDDKNNTHPITSSSSAAATRASLVSELAAKTRLAQDPFLQARTQPRLPSLVSELAAKTRLAQDPFLQARTQPRLRGVKRKRLDSRPPTAKQAFILSALVQYDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L813</accession>
    <name>A0A367L813_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">O-methyltransferase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_4323</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L813"/>
    <dbReference type="STRING" id="1330021.A0A367L813"/>
    <dbReference type="OrthoDB" id="1535081at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF2">
        <property type="entry name" value="O-METHYLTRANSFERASE CICE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="80"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI10559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="309" mass="34293" checksum="C584144CD4DF4B08" modified="2018-11-07" version="1">MSGFLEQTDGGEYRHSKFSRAYRLDEPGPGHMFLACYDHVLSPFHNFVEYLSQRGQLPSNAREPDDPLHSPMTHHYNQDGVSPWSTMEQNPERMRDFQFAMDTLGEALPVVGTFDFRLLRNEGLDESRGRVQLVDVGGGHGTVLGGVLAAYGGSSLRPETCVLQDRPGVVELSRRNRALPDAVQRMNHDFFTDQPVKGAKAYLMRAIIHDWPDAACVKILTHLAAAMAPDSRVLICDPVLPPRLGEDNFFIAIVDHAVMALAGKERTEKAFSDLLDQAGLELVRVWRVSGGAQIGACVEGRLKRQSSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8I4</accession>
    <name>A0A367L8I4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5177</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8I4"/>
    <dbReference type="OrthoDB" id="3599317at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="99" mass="11424" checksum="EC7C9F8EA22EE676" modified="2018-11-07" version="1">MAERGNFFKKSIPSQRAEPGLITSKGYTSKKKKRNHVIKVRKADADDSSKYFSRYFKVPTCSTLTYLYKIGDLEEDLYVPYPAVSAVLRGVWVRIRPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8L7</accession>
    <name>A0A367L8L7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8L7"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="105" mass="11939" checksum="6C105B8A765C556B" modified="2018-11-07" version="1">MRVPANLTLSMHPIRTHGRDLLSCYYYPCNPEIRQIGRIEGSTTLYNRVETVLGRRTRCPRYRTTLGTTSRPTSTSSIGTRDAYLGSGRPGYQGGSLPYSYRDRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8V0</accession>
    <name>A0A367L8V0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8V0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="239" mass="26342" checksum="58B9261C2101B994" modified="2018-11-07" version="1">MSVTDSIVYSNQREVVVALCIKPAKRFSVLHHSHRSSKTISMKASLTASLTAMLTMENLSWASPFNPTPTVDPHATPQSTASTGADNRIPPSIHAQGSFHYPKDKIVLNISTYHRQLNDVGQSWHRLVEQTQNGLASVALIPLPGPPGINPPSSSVPVRALRGPIEPLRRGKLIRGQSPFQLKVVLLPVMAFMRALETPYYSLIRLAELMSVRPSVFRSVSAGRFLLYPLHPGEAYYET</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8Y7</accession>
    <name>A0A367L8Y7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal RNA-processing protein 41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_5200</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">Component of the RNA exosome complex. Specifically part of the catalytically inactive RNA exosome core complex (Exo-9) which may associate with the catalytic subunits RRP6 and DIS3 in cytoplasmic- and nuclear-specific RNA exosome complex forms. Exo-9 is formed by a hexameric base ring of RNase PH domain-containing subunits and a cap ring consisting of CSL4, RRP4 and RRP40.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8Y7"/>
    <dbReference type="STRING" id="1330021.A0A367L8Y7"/>
    <dbReference type="OrthoDB" id="437922at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.70:FF:000004">
        <property type="entry name" value="Exosome complex component Rrp41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF0">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="8">
        <location>
            <begin position="23"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00063066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00077929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI10888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="277" mass="29514" checksum="2966A73FED485D85" modified="2018-11-07" version="1">MPLDTSAYGLGLLRVDGRRWNDLRRVQARLRTQDAADGSSYLEMGHTKIMGTVSGPEELLTRRGEKGGGASLLEASASVVVRIVVAGFAGVERKRRGRNDRRIQEMETTIARTFSSVIHTHLFPHSTITISLHVLSTDGSLLAALFNTATLALIDAGVPMADYVSACTAGSTSPSNESDISSSASSETDPVLDLNAQEELELPFLTLAAVGEGDKVAALVSESRLHVSLLEPLIVVGLDGCRQVRALLDGVVGERGRRLIREGVAPRGDVLFAEVEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L931</accession>
    <name>A0A367L931_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_5168</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L931"/>
    <dbReference type="STRING" id="1330021.A0A367L931"/>
    <dbReference type="OrthoDB" id="2351791at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF9">
        <property type="entry name" value="TAH-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="559"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="53"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="84"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="625"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="647"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="661"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI10927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="745" mass="80944" checksum="020B037596D5B9EF" modified="2018-11-07" version="1" fragment="single">GSGDDLVISAPPPHPFTRGKTVAQWQYRAPQPPSDQSQPQMQRAEVRSRISNACDGCKARKVKCDGRLPCGYCAARPRSGLCRYSSQRRRQRARPRTTEPEAQPEPRLGPEPGPDGADGIPPSSSPSTAVVVEDETEVPREARLLCDTQGKLVFIGDCAPLSFFQSVRRLVTNRVGRDAFAPGSSRFSLLENAAAAMTSSTAISVPPVLSPTDVASAVANYLAMTTGLVDLFDHRRQLLDGLTLWASGRQRPVNDDGDDNCSSAVNFLVLAIGRLLDDEHLSHVYFDHGRDLATASLDGSLGVATVQAFALVAVYMLCSCRINGAFLFFGIAVRAAYSLGVHRSEVNARFGPDGHRRRDRLWQSLRVVDLCLSTAMGRPPATSDIDCTVSYCREEVDESHVDLLGASVQILLITESIVLEIYSRRKISLQLTEGISLQLRDWAFRWMPHVRRVLLCRDDDDDDDDDDGHVHAQAVGACQVLASYHYAVMLVCRPFLMCELCHRLTDAPLSSSASAFSSSSSFSGRTRLADACIDAAGLMVEPVLDLIDRGVLNVRVPLLISWLFASSLVLGVGLLGGFGRNLEKTCRMSIRAMDHFSKIDGHATQYSLIAQSLLETTLAYLERRDVEERQRRTQSSTQLFGLMPSEMPTSNSPLQPQHPTDNPERRAGEGDPAKGPVGRSDQRSPASFADAGFLGLSESSLQTPDTDFWSVGSLLGAEADAAAASALNLFPLLDAGGSIDLAHHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L956</accession>
    <name>A0A367L956_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5372</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L956"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI10960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="67" mass="7864" checksum="20730E7C34F5592B" modified="2018-11-07" version="1" fragment="single">MLIILPSTSRDTLKYFSRYFKVPTYSTLTYLYRKTCSNLTDLIDLINPIDPIDLTRYNRYNVPAIAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9B8</accession>
    <name>A0A367L9B8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutathione S-transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_5256</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI11017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9B8"/>
    <dbReference type="STRING" id="1330021.A0A367L9B8"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03192">
        <property type="entry name" value="GST_C_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03039">
        <property type="entry name" value="GST_N_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF263">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="6"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="101"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI11017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="28160" checksum="96FAECD642BBE253" modified="2018-11-07" version="1">MPSSSEYRLIYWPGIPGRGELIRLLFEEAGVAYTDTAKGPPDDAVAAVTSRLDDNTPPLLAPPILQHGSVTLSQTANILLYLAPRLGLAPAAGDDGMYHLNGIVLTLLDGFVNEVHETHHPVATMDYYESQKPEARRRSKAYRQERLPKFLAYAQELLTTGDWLYGGELSYADLVLFQGIDGSSYAFPKTMKKMKDSNRYNDVFRLYEAVKQRPRIKAYLDSRRRAPYSTGIWRHYPELEEEEEEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2024-01-24" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9F3</accession>
    <name>A0A367L9F3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7452</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9F3"/>
    <dbReference type="STRING" id="1330021.A0A367L9F3"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI11061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="163" mass="18871" checksum="F3B8A2FE464DF803" modified="2018-11-07" version="1" fragment="single">TRCKDIRTFSRKKGEFSAFLTNLKDKIRTDKATFRDEEDRIGFLFRSLKGKARKTLETRYDSIEQPFSGLAEIIYLLTKTKDDSLSYEDFCGYVKDSVYCRKRDAAVKRLDAKLVLLAEKKLLLDYAARKLIWPNDLPALAKYSLLILLPKTPLLNRQIDPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9P6</accession>
    <name>A0A367L9P6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7446</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9P6"/>
    <dbReference type="OrthoDB" id="5001282at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI11134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="84" mass="9949" checksum="F9F4DA74C815203D" modified="2018-11-07" version="1" fragment="single">KEEILDTTPLEYFVSWFLGPREQSTIAIKLKVPRVTYILAKLAYPQGYFFKQLIEVYRPKYYRAIIIAREVPSYADSKEDREAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LA17</accession>
    <name>A0A367LA17_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LA17"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017026728" evidence="1">
        <location>
            <begin position="17"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="104" mass="11685" checksum="FFE9E3F5FC9C9878" modified="2018-11-07" version="1">MKVFLFVAALAGVTLADPFLPDNAKARYRVRIRIPDWTDDMSKTKVNRIVTEDDSDMMCMYIGGITCFSDLTYPAIAWLNAIDGVEPVYITKKDDKRTCSLGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAG7</accession>
    <name>A0A367LAG7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_7547</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAG7"/>
    <dbReference type="STRING" id="1330021.A0A367LAG7"/>
    <dbReference type="OrthoDB" id="5421757at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI11411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="347" mass="39833" checksum="8880DF514CDEF0D4" modified="2018-11-07" version="1">MAPSKRPIKAKSKGISDEPPPPFKRPPQVLRPFVDGLVERHVYVTHIDSHPAAFKRKIFLVPVAMNLCISLLFVWRMYSILPWYWQLVLSALGHTSEATFATSQSSWAELTREIGRRGLTMFIDFVLFVFVWPWPVDFAASRRHGNPMLWRRCVGFRDKEIYVRRSRSWDEAVGDVLAESESRDIVTAYIRQATSPLLQDQKTGYLLMDGAWDLDWEAMVFAHALVDKKHIALEAFRSVALLHHRHYGWLCYDLKAGAEADSEDKRRQVFAFRDALTSMGKEDLFYRWVETVQFETTQPGGFDAAQQEATAKKIRGMFEAEDINFDELWMEATGGKQAFSNGTDSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAS8</accession>
    <name>A0A367LAS8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7718</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAS8"/>
    <dbReference type="OrthoDB" id="21502at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI11514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="484" mass="54903" checksum="B31A89B361B9449A" modified="2018-11-07" version="1">MAEDDDDGDDVYPLHAFDDTQYNRKLLSWLMRFNDVLDPGRLHGALARLLDIGDWRKLGGRLKLKPSGKLEVHAPKHFSPDRPAVSFTHQDFSGLPIEEHPIARRFPEPTDGPSIQPISDFRPFLAPRDYPKTLQDMISRDLPQLSLHITSFRNATLVAIAWPHTLMDAIGQQALLRSWSLVLAGREQDVPPILGAREDFLKELEDDESEEEREPLALERNRLGMLGSFAMIARFVWDRFWSPPLELRAIYLPGKTLSRLRAQAQKQIGELPENPGHDDRFVSEGDVLTAWIARAVSLPRRPLTLVSFFNPRYRLPRLRDETTGVYAQNMTQLSFTFCSPHLAGGDLGHLALQHRRQMAEQTSGRQTLSLMRTMRRGIEAGKFDVFFGEANALPIFYNNLTRVDLLKAVDFGPAVLSRGDSKPKNPPGTMVMYYNQPVDGSLRGPSSFYMLGKDYADNHWLMGDLLPQAWTRIEDELRALEDGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAV6</accession>
    <name>A0A367LAV6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L249_7345</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LAV6"/>
    <dbReference type="OrthoDB" id="162894at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901992">
        <property type="term" value="P:positive regulation of mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05611">
        <property type="entry name" value="STKc_Rim15_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000340">
        <property type="entry name" value="Serine threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000664">
        <property type="entry name" value="Serine threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000139">
        <property type="entry name" value="Serine threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:001008">
        <property type="entry name" value="Serine/threonine-protein kinase cek1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE GREATWALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="730"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="14">
        <location>
            <begin position="1156"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="13">
        <location>
            <begin position="1522"/>
            <end position="1636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="278"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="357"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="456"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="527"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="708"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="888"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1003"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1196"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1290"/>
            <end position="1462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1670"/>
            <end position="1702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1765"/>
            <end position="1916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="301"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="491"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="535"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="590"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="617"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="631"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="906"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="925"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="954"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1290"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1336"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1376"/>
            <end position="1389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1440"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="1784"/>
            <end position="1793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1831"/>
            <end position="1852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1874"/>
            <end position="1890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1904"/>
            <end position="1916"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCI11549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1916" mass="207926" checksum="D7D07B6B4A3E46E6" modified="2018-11-07" version="1">MAENPPLLAPPAVVSLRAQQAGPMERSLSQDIRDERDELREAAEQTLNVIVDLNLDGTIRWVSPSWTDVVGSPADTVNGTPISDLIVSKNKSVFSDVVESMKRDDSRSYRVTFSIHLGPLSKLRPMPIVDHIQAPLSDAAEPLTADLEAQGIVVYDSVSGGESHTMWMIRPWSGPHEIKIDLPDVIVDSLGSGAEVLASYLTQLAESGGEDTQEREPPPSVLCRICERQIHPWWFEKHTELCLQEHRAEMDVQMTQESLTEHRHAIVRVLDVLEARKSRSMTGEQTAGPAAEYKGMPIGPSPSSQTSPATSAAPSRDRAGGFGHARARSFAVRRPLARIVELLMDLCDTAIEISSPAIKESSSQQDDGDFRAQSPQSESRISQVLQWQSPSTNTLEQEQGLALLCADTEKVARAKVEAVFRHRRIIEYAERIRIELAVLVQDCIARALRKAARLAAGRLSDSTEDEEDAGMECIPENTSGAGVLANLTGEAPRDEEPRGRSEQGLARQSLDSPSVLAAALRQMDLSAASSRSRSQPASFVASTRSSSPKECPTPRSHVEGGLSAQLQPRDARRSSSLVFETDPTDAEGSMRSSSGASRNVLRTESPIPEFGDLRRAASARHHHRRSLVIPGTSSPRRQESPSRAVQPSSPLRIKPRVLPVSQEGAASPEASPMFPCSEFSSPVSHPSRHHRRQSSAAISDLVMRAPSSPRLNASQAPPQPRPAPPSIKDFEIIKPISKGAFGSVYLSKKKSTGEYFAIKVLKKADMVAKNQVGNVKAERAIMMWQGQSEFVAKLYWTFSSKEYLYLVMEYLNGGDCASLIKVLGGLPEDWVKKYLGEVVLGVEDIHGRNVIHRDLKPDNLLIDQKGHLKLTDFGLSRMGLVGRQKRALNSEAADSTPDLLKQGPFARSTSMASSRSTSLDLHGHTQSPSTTPQTTPDASSAAQPSFFSLAPLSHEPRRISSSHRSDSGGSEAMTHMLSSFTLNDADHLSQPSSAKLVTEDEAVPYGSPDLPARASADGHARNSLPQSNMMPPRMALFDPQDTNRRFVGTPDYLAPETIKGDVQDETSDWWSVGCIMFEFLYGTPPFHAGEAEQVFENILARKIQWPEDGMCEPVSEEAKDLINKLLCVNPKQRLGANKDEKFASGGEEIRCHPWFHGINWDTLFEDEAQFVPHPENPEDTEYFDARGAVLQSFAEEMEDQMSPHSSTAGSDYPDRPHDALSRVRSQVNSMNRKLIPLHIPPHVRDLKTRRLSEPVATDDFGSFTFKNLPVLEKANKDVIQKLRADALAAQSKQSSGSPCAGTTNVTTSPAPSLDASPVLSSHLHRTISGAKAGNRPQSPSGFSHSNSSPSRASQPSSPLLVSFIAGQGAEGRRKASSNSSSLSHHSASLQPPTSFEIPKVPPSLQKAATSAAASPVKGRGSTPAPLALSPQKLMATPRQGSASSTSRSRSLTLGSQEASPVTSEILSYHRNRRSQVFDMSPSSSDNEGDKHNALLRVQRRRQSSRRLSQVNFDSGPTFRPLDVLICEDHPVARMVMEKLLEKLHCRTIAVANGSQAVRYSMSEIQFDVIFLEFKLPQISGADVARMIRETKNSNSHTPIVALTAYLKELQAPHYFDSLIEKPISSSKLIEVLRSLCQWQPESPQRATSFPQPHPALASLRKAAAARADDSLESSASALTGRQGSGLGSSRDDSMTSSMFGDGESVAVDDTAVATISRNKASSGDWGEGGGLGIADTEAAGVECSVRGAPSLTWQHSAPCQMEHHLLRPHPQRKTGKCEVAEGTESADDEDEETESAKDKQPGRGSKPMTGKSALPSSKLGIEMMRADSHESVAQCSESTPEAVTQVVTTPSQEMKPPILGAGSEDAAPGRQKGGKTEADGPAERGDEQLRSVDATPRPTLSYRGVDDEATPRPADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBC9</accession>
    <name>A0A367LBC9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7616</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBC9"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI11738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="69" mass="7576" checksum="F856312F261BB383" modified="2018-11-07" version="1">MLRSTARKDAYTEANYIAKEGTPCLTCSKEAAVRRSRAVAASYVIMPFLPLLCNVRRPRAGYGRPGVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBJ4</accession>
    <name>A0A367LBJ4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7428</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBJ4"/>
    <dbReference type="OrthoDB" id="3599317at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI11784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="135" mass="15177" checksum="FA2DBC14A5966923" modified="2018-11-07" version="1" fragment="single">MGIISISFSHLLNTNTSPASNSSLIASFRLLPRAQLSDSGYLYTFNLFFTAFLFTFRPTNYLIRTALRIDSLLIREKLQGALGSIAYNKSEDALALIRLQLEDGPLTQIMHLRSAKEAWDKLKDLYNPVSQGYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBM7</accession>
    <name>A0A367LBM7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rgp1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBM7"/>
    <dbReference type="STRING" id="1330021.A0A367LBM7"/>
    <dbReference type="OrthoDB" id="1918at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014848">
        <property type="entry name" value="Rgp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12507">
        <property type="entry name" value="REDUCED GROWTH PHENOTYPE 1 RGP1, YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08737">
        <property type="entry name" value="Rgp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="269"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="849" mass="90855" checksum="CF8C22D08D4511B3" modified="2018-11-07" version="1" fragment="single">ASEDQQTALRRPHLCPVDTEFRSRRNAPAWPFASRRLPPAMSPAVAPGHVRVFVGWRDQTVFAGEEVKCTITFKNVASDRLRRRPRYQQQQLQQQQLQQQQQQQQQQQQLNSPLCTRGHGPTSPRSVRGHRRSALSLSGPPSNSLGQPGSMQWPQTASGGDWSRGHTHKRSLSIVSIGSAAGADDHGSLHDVGAKPQRGHGRAASLQILPRGPTSCPPSDRFGRMTVPNTPSGAGPRRSPLGSPSLLSDFRFPTEASSSAEAVEGSTTNSAPGTHGSPTGSHEHGVATRSKEHAQPPPDRSTARVLSSSSAPGGTPRSSGEFYSLSNNSSETLASEYVHHKLMRGHGRQRGPPRRSLGTTPSQARAPESLMMAYAQIQGSFCLDGSLISLGPFEHVKKAAVGGRGGGVVGLEPSKRESGLLRSFGWANISSSLGELLGGGELSSIKEMRGAANSKSVPLLSTPQSILFVDLQLAPGESQAFEYSFKLPKGLPPTHKGKSVKFSYSLVIGTQRAGGAKEHQVRSVEVPFRVLGSVNSQGELLGHDLMNPYVLLRDEAKVSSLGRGSSSKPRVQRPAMEGPGAKADFVSYVDGLLARRRDGQGGTLQSPTEAVASRRPSALEETTRAKDAIDLAIMRSNVTGEGQQSPNRFEISRNGRRVGVVMLTRPAYRLGEVINMAIDFGDADVACYAVHVTLETSERVDGSLAVRSESSMQRVTRKVYVAASEATLFARRVTFSPTIPVSATPEFVTSGISLEWKMRLEFVVPYQGGEAAAAAATTTTTTTTSEMPMAHPLLEPVSHDSKGGLVLVAVEKVACESFDVSLPLRVYGAVGSGLERLERDEASEEGLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBR8</accession>
    <name>A0A367LBR8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_4218</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000009">
        <property type="protein sequence ID" value="RCI11870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBR8"/>
    <dbReference type="STRING" id="1330021.A0A367LBR8"/>
    <dbReference type="OrthoDB" id="5382468at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12418">
        <property type="entry name" value="RRM_Aly_REF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051229">
        <property type="entry name" value="ALYREF_mRNA_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025715">
        <property type="entry name" value="FoP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965">
        <property type="entry name" value="RNA AND EXPORT FACTOR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965:SF82">
        <property type="entry name" value="THO COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13865">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1136"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="37"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="139"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="397"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="785"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1050"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="151"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="408"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="790"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="877"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="917"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1077"/>
            <end position="1099"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI11870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1159" mass="128532" checksum="7BF82F2F499011E4" modified="2018-11-07" version="1">MIHETSIANGFTIASRSAALAEVTPLDADADPRPASSKIRVDNVHYDLGEDDLDELFTRIGPIVRLDLRYDRAGRSEGTAFVTYERADDAQEAIRQFHGANANGQPIRLSLVPGGPSRNPFDTAVMPGRSLADRITVPGARSRSLSPRRRRYDDEDAARKGIDRYIPEDDGRARSPLGQRRGGRRPGIRREDNHNNRGRGNVRSSVRTKKTQDELDAEMEDYFGSNNGDLIESLDISVAGSIKNGDFVNVGTKGTFAKKDTACCSSPFSPPLFLKLTPCPKFDASTYVFLVVADVRRQPAVNRHYKFQWKPTANPHLVYGDRFISGFIEGGALFAKVSITVKDESHKRDIGASLNVAFKMFGRGVDVSTSVQHHLKNIKKKSTVAIDYHWVGAPPDFSPKVPVPPPDNKGRRLQSPERYYKRDSDDDSSSGFGEEPDELIKLKDIADRFINQAKAHSWKRLAILDQYPNSDEWKDEFTIPNYSSAIDRSWSVFKDFGDLKHVIETIKRVPEEYWLRGSRVANTLIQEGTKYAEDFRQWVDKVALQPKEAENLPDIDVLRFRRKVLYEIQTQRYYAHHWNYTTKPYFSVDVFTKTSASDVLFEAQVYEFPLFGSVRIAFGTQPYIQRADNEDSYLCVIGDDDFPPGYHKFAEFWAFPRYIPGVTNGLVRVDVKRASYSTIRLTVVDKALDRRDFESGGGEWQAYGQFYLANVSYPRPVPEEEVVSSKRRAVRLSSFLGPKVYRNETSPAVLSAATSFVFFGGGDGEGMPPPHDEVLWKNTTTALLPDAGSSDVQPDTTNNSTLHPQLAGNSSVYLRPTGNSTLLQPGVNSSLHLQPTGNPSLQHLQPTTNSLQFDKSSLHRQPSGGSSFSSHRAETIGSSSSHGHLTSSSAEISSSSSSSSSSSFTDDLLNSWNNNNNDDDDDDDDDDDDDTTKPPYPNGHVSTVDVEMKCYGTVCLPSCVDCGNFRVACGQDACRVERCALSERNRLVVEDGSTLYTDMTTTCARGSCSSRRCGEGGECDKNLLCGDETCSWEPCSAAVCRQIVMRDEAATSSTRPSMRRPTQEDDDGSSCSAGLAETEHQSALDHEQEKKKPAVEFRVEPSNAEPRPGVTREPGPRTDRPGTAGKMAGSASKPCFSFGSVVVAWSMVFIFRLLADYAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LC88</accession>
    <name>A0A367LC88_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_0678</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LC88"/>
    <dbReference type="STRING" id="1330021.A0A367LC88"/>
    <dbReference type="OrthoDB" id="5241662at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451">
        <property type="entry name" value="MARVEL DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37451:SF1">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="7">
        <location>
            <begin position="20"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="155"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="225"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI12021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="272" mass="28990" checksum="7F0A5CE669D7FE1C" modified="2018-11-07" version="1">MSQLRVEEDRHVLRTPMWVLIIRSAQSVLSLLILALAAAIATRNYADEAGLALAVALLTWLAITYMTLTERLPSLRAGYHVLAVLALDGLLVVLWLAAFAALAARRALLSGYTGIEGLTSATAGLGSLQWILFIVTLVWGLVSFFKGRKQGRFPLGALEPSPSTTEECQMETKPSGPPTRQGAETMPAPSPYPTAPRSSPSPCPTPQPTCGDGQAVTTHGPDCGFQTQQQALSTSELPAQELAYNSPSPVVGSPTPPTPLLVGNHHDHHYHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCI6</accession>
    <name>A0A367LCI6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_0577</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCI6"/>
    <dbReference type="OrthoDB" id="5417811at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI12134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="332" mass="36288" checksum="13A4F7D8C6FCCB88" modified="2018-11-07" version="1">MASGPRSVNLMRATREARAANQTTTDSRTGRSDLGVFARLGHLAQSLGLTRHDDDGAKPPTPGLAPPSQSQPAAPMPSSPGRVAIPLDRVPYEVSAPMRMRIVDAPEEAPRASSSGGRLDRIRSNRTQDSIERSCFCIPTTKSRRVRSQIASCVVSGIVFIVVLGVYVGLSVSNSIRQSELTIVVILIILAAGIFFCFCLIRLWLFVNRPERIDGRRALVPDLAHQYLVPPKPIPVVLAQDEEAVGIRGEAATSKPPAYGRWMETVRVDPNRLFWQRNEESTEEAEPDAGPRPPSYASENGVDYVLEAQPRSVAPPSTAVYRNERSSVSRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LD46</accession>
    <name>A0A367LD46_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SGF29 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_1103</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LD46"/>
    <dbReference type="STRING" id="1330021.A0A367LD46"/>
    <dbReference type="OrthoDB" id="10265994at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20393">
        <property type="entry name" value="Tudor_SGF29_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037802">
        <property type="entry name" value="SGF29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010750">
        <property type="entry name" value="SGF29_tudor-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047288">
        <property type="entry name" value="Tudor_SGF29_rpt1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21539:SF0">
        <property type="entry name" value="SAGA-ASSOCIATED FACTOR 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07039">
        <property type="entry name" value="SGF29_Tudor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51518">
        <property type="entry name" value="SGF29_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGF29 C-terminal" evidence="2">
        <location>
            <begin position="222"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI12340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="358" mass="37261" checksum="5CF8C3070F145F98" modified="2018-11-07" version="1">MSQRNRSGRGSNRNNGNNTHGEEAQIWEACKSQMADIVTGINAENDSLRELVALDKQVGAADPDQVPTDSLKQMEQLCRKGVKFSESNVSSLKGVVEQLKILRAVVVAKEQAEAASSSSGTGKRAARDSAAAATAATTSLYEFDGAGDSPVPSPMAGGSGGGGGGGGGGGGGSSASTRKHGDRSSNRDSMPPKADSVEPQGPGGSGGGGGGSGSNNNNNNRSRIVFSKGDAVAFKPKAASGEPTSDWILGEVAQVLGEGKSRRYKVLDIEPDDQSKQKEYRSSASNMIAITAESQAGTLRDWEAGKVVLALYPNTTTFYKAAVHSMDGGGRVNLKFEGENDSTTLQQVERRFVIEYRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDB8</accession>
    <name>A0A367LDB8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_0453</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NGG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDB8"/>
    <dbReference type="STRING" id="1330021.A0A367LDB8"/>
    <dbReference type="OrthoDB" id="1232at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019340">
        <property type="entry name" value="Histone_AcTrfase_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13556:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13556">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10198">
        <property type="entry name" value="Ada3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="100"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="325"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="377"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="100"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="159"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="377"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="395"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI12410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="638" mass="70673" checksum="97D0A55DDABDBBE6" modified="2018-11-07" version="1">MPPGSSQAGPGKKNAAVPKQSRNSTPPPSSLPPQEFYDPDYLNTRVILFNNLTYDDLVDQGAYNATVPDSKSVDAMLEKLKSLISIMEKRSTFYDRGMRHLADERKKRPDDYEQARHETEPDGKKSKHKRKKGSESLAPGDYDQSSPLREAKRRHSRDGSASSSLSPVATTSPSAMDVDKKPKEGDKEEKTSSEDEGAPPRRELPQSQTFGEDPSTFPDPTVYEIRGIQSGMSVEEKKVIYSVASYPKSDLADVIAGDPPDKDFSIAKPSSQINFTTFSSYLEPYFRPFSEEDLAFLRERGDRVTPFAMPKRGKKHYTEIWAEEDGAMSIDSPQQGRDTLPPNQPRGSIESMGDSIGETDSLSIGPLASRLLQMLRPERRSQPAEDRPMTNGIPNGEVAANGDANGDDQAGGSGDDKAGRLPPATFMAESSTEAWKKATHPKLEYAQVDERLKQELRHIGFLPQDDFEHDYDGHYDDEVAGRLRLLQSRLREQMLINGARKARLTELVRERMAHQEYQTILEDLDSQVQAAYLKRTRTMGKSKKTKRPGGAGGGSHFVGASAAAAAAAGTARPGIGDLTRTLMERRRRWIDTIGSVFDDESLGRVPRSADADSSIFKKEEMAALVKREKAAWDDEAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDQ7</accession>
    <name>A0A367LDQ7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_0835</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Mitochondrial ribosome (mitoribosome) assembly factor. Binds at the interface of the head and body domains of the mitochondrial small ribosomal subunit (mt-SSU), occluding the mRNA channel and preventing compaction of the head domain towards the body. Probable inactive methyltransferase: retains the characteristic folding and ability to bind S-adenosyl-L-methionine, but it probably lost its methyltransferase activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDQ7"/>
    <dbReference type="STRING" id="1330021.A0A367LDQ7"/>
    <dbReference type="OrthoDB" id="421327at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052571">
        <property type="entry name" value="Mt_RNA_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015324">
        <property type="entry name" value="Ribosomal_Rsm22-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13184:SF5">
        <property type="entry name" value="METHYLTRANSFERASE-LIKE PROTEIN 17, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09243">
        <property type="entry name" value="Rsm22"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="116"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="223"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="805"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="805"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="821"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="842"/>
            <end position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00045681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI12558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="891" mass="100027" checksum="CBB97F1B81670310" modified="2018-11-07" version="1">MLPLATRARRACQCRCSSLAAFSSASVGHGRRLSSRSFGTSKCMPAEKDDGGGEKARHMETVVREAAQRFRGTLPKGYLSDQEYALYKRLYGPPQRETEPEDVGIPTHADLGSWEEVKGDEAESDAHSSLDPKEEEEEQADDDVSSTTSTDVARQNMEAIEQTADGYVNAVARNEREHKALLRLAEDFKATRRELHRKIEEQSALQKEVAKKEEAELALLQGLEEDLEENPDEDLKDRLDDRLSNPKQEAKATDGAPDGAPDGTPAKKGRKVRVIQKSRKALLRLEREAEDEHEDPPDRYHPWTLLGRFHDRPMALTIPPKDLDGPVRQLLSRTHIDHVKKAADLIYRDKSFANSPATIPGSKSSPMEGVALPPDQRSMSSIEADAFLAVFMPPAYASILRILSEVRKRIGTEWLQSRLKQGARGQLSILDAGAGGAALVAWDQIVKAEWGVLKEKGKVRRGDEPPPSKKAAIVGSSRLRERVVTFLPDATLLTRLPDYLHSGQTKGEHLEAGDQQQQQKQYDIVVASHLFLKEDAGHRRQTLLNKLWTLVSSNGGILVILEKGHPRGFEAMAHARDVILNQFLLPQSGFPLMDVRNGVNDDEVMYGSTDDAKTPMGGEREPGYVIAPCSNQGTCPMYEASGLGQGRKDYCHFDQKFLAPPYYRSVTAVKGSGNNQGRVEFSYVAIRRGVDRGKKLGGLQETRNAFDGYFDTEGGPPDMQMLPRQINRPLKKKHHVIMDMCTPEGKLERWTVPKSYDPLTYHDARKSRWGDLWALGAKTRIRRRVRDGEIETTKKMREKFRKQLRTQLSGKKSHNRQVVESSEKREKQEDSVDSSESSAGLTKRKLTKTQKKLLGKEKRRVKKEMKRQALRDKKRKAMATRGEGKDDEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEE0</accession>
    <name>A0A367LEE0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_0095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEE0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI12793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="282" mass="30699" checksum="C71823D251E300B7" modified="2018-11-07" version="1">MGCLASSARPEASSPAVESAMILSTAAMKEAGTARCPLFTSSAAADPATQTFSFFLLLTSDRADASSNGRPDRTSSRALDDEAGHVTGNDTGGAQKESLAAVAGEPVLNKCEKVAGPGGKKMLLLPRRRKLNQPLHQTGARLAAGELQLLAPGLAVDVFDEEVAVLDGGELVQLQHLVCAAKVLLLLVREHAEEEDGLFVVVVIFLRAGRPRPFRISFFGLLLMFTLALFAHRVTSHNRQTLERKFVRQKRAAANLELITHKKHTDRRTILRFRRLRMLQDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEI9</accession>
    <name>A0A367LEI9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_0970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEI9"/>
    <dbReference type="STRING" id="1330021.A0A367LEI9"/>
    <dbReference type="OrthoDB" id="3757673at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI12839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="238" mass="26602" checksum="EE882C6E9C9001A8" modified="2018-11-07" version="1">MAELQWTVILVPTALCLSLVVIAQVVVIYSSAYLAAPHEVAVLVDAVDFSIQENESYDRDVAKVQRLEDKIRLGRLLREIQRGGDDLREHLGRLLLDEGATTMNPISRLLWASHRVELREKLRTLDLLRMRFLVVYMGIIASAAAAASRSPPPPPSPPEEKTSTLPSPVTPTLHTSLAETIARRPPLRRLTTQAIGHQETVARPHRKGWAGVVEELQTSPRMQRRHASIEQAMMTRPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEP8</accession>
    <name>A0A367LEP8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_1347</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEP8"/>
    <dbReference type="STRING" id="1330021.A0A367LEP8"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1300.10:FF:000003">
        <property type="entry name" value="Amidase signature enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013536">
        <property type="entry name" value="WLM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF10">
        <property type="entry name" value="ACETAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08325">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51397">
        <property type="entry name" value="WLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="WLM" evidence="11">
        <location>
            <begin position="582"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="10">
        <location>
            <begin position="860"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="550"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="740"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="891"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="899"/>
            <end position="911"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI12899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="974" mass="107750" checksum="7C5147006D51F73C" modified="2018-11-07" version="1">MDGSINLKGALAGIPVSLKDTIDVKGYDSTVGMSCYVDKPKSDDGPMVRMLKDLGAVPYVKTNIPITLLSFESANDVWGRSTNPYNRNYTPGGSTGGEGALLALGGRIGIGSDVAGSVRCPAHFSGIYSLKCSIGRWPKLGATTSIPGQDGVPAVYSPMARTLNDLIYFTRAVIENGPWNYDPSCHPMPWRPDVVNEYRDKKTLRVGVFRTDGVIDPSPACKRALEMTEAALRKAGHRIIEIEPPSPYDGLRLASRLLCADGLGTVMSYLRTGERNDCGAAQLRFYARLPRFIQYLHYLWVRYVRRDPLWAGMLRDWQPRTTREYSALISQREAYKRRWFDMWEDAELDFIIAPPNATPAVPHNGMHDAVSSCAYTFLFNLVSYQVCLARSRYLHTDGRTQIDYSAGVIPVTHVDRFKDKLPSNFKLRDLNGLARGAYKFYDPDAMHGLPVGVQVISRRLEEEKVLMLMERVEDALGANKFEPLALADVHCELLLVKQSFHVAAIQGPGSVLSSHSGLAIFVVAHFSIRSMSLIRSRRGDVDLNLIHPRRAANRRSQEPSGSIASQSPGAAARAPAGSRCVTGMLEHEPLVRSYVHLDKEPRADEALHTLRKVASLVKPIMRVRGWKVGQLAEFYPSDPSLLGLNVNGGSKICLRLRYPGDRAQFMPMENVTDTMLHELCHIVHGPHNQQFHALWDQLRDELQGLMMKGYTGEGFLSQGRRLGGWRMPEHEARRLAREAAERHRRSHQPPVAAPGRRLGGTAPRPGQDIRNVIVDAVQRRNKVLRGCATERLTAREMQEVADSATSNGFRTQAEEDEANDVAIAQALWELVQEDEKKRLGSEYVFPGEASGRETAGGGNAAGTWTCEACTLQNPEQYLCCDACGGERSRSLSASEAARRPPPPPPPPPPTRPGTLPRVGPHHPPTAVGRGRGRGDKGPMVVDLTQGQGETEPRSLPPTWTCSFCGTVMERQWWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEV1</accession>
    <name>A0A367LEV1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_1323</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEV1"/>
    <dbReference type="STRING" id="1330021.A0A367LEV1"/>
    <dbReference type="OrthoDB" id="5584247at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052246">
        <property type="entry name" value="Cell_Polariz_PKAAnc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13155:SF1">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13155">
        <property type="entry name" value="A-KINASE ANCHOR PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="251"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="RGS" evidence="3">
        <location>
            <begin position="171"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI12946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="362" mass="40785" checksum="4801DE22E124A4FA" modified="2018-11-07" version="1">MATPMAPPSPSPQPDLSRNRLPTLFEVLSRRTLPPVDLFSFYIYMRDQQRSVDYLDFWLDVAQHMSLCRHYVRELRRSVLVATPDVDKAGSKRSSAILESLGDLEPRTAGPSMYTSEKERDQDAQMSAFLREDQPLDSPHSGSGVARPSPQYSTPQNVTDSNSPSHTVARQDIRASAEKILYTFLLPGAEREITLPGSITQDVTVAIEDEGRDDPEVFDVAKDYVFQAMERDAFPGFLRMKALGNLIPPTLVMRLIIGLVSMFGGFWAGFVLIFLDSWRATRCWLILPFTVGVYFLASYQYSLDPIMALVGFSEYTPFNFSRIREPYVRRLLAKRALMVLAVTLLVDAALCVLFILVPGKRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LG23</accession>
    <name>A0A367LG23_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7492 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_0303</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LG23"/>
    <dbReference type="OrthoDB" id="64281at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055915">
        <property type="entry name" value="DUF7492"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24320">
        <property type="entry name" value="DUF7492"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00049">
        <property type="entry name" value="WILMSTUMOUR"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017049631" description="DUF7492 domain-containing protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7492" evidence="3">
        <location>
            <begin position="22"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI13384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="461" mass="48759" checksum="0DD0CF0F93F62E2A" modified="2018-11-07" version="1">MKLPFANNGLFGLLALVVGFAKSHSWIESAFVIAPNGSFIGAEGFPRGYIPRSDPSFNDKQAQHLIPDGAFYSGNEVLNKFPASAYNPQFPMLQAAPGQRVAITHLENGHVTLPQNQANKPLNRGTVFLYGTTQPRDQEKLFDVHLRWNQAGSGGDGRGRLLATRNYDDGQCYQDNKQPIAQERVGRLAADGASLDRELRCQSIITIPTDLKPGSVYTVYWYWDWPTLNPAKINMQDTQAGRFPWAGSFMRGDNVPDGWTINAISINESYSSVMDIKIVQPLPGLVAKQGDVSQWITSQNVYGAGVQSQGANNGFDVKVDDYIGGGGGGAVPLASAAAAAPVPSQSGAVSPPLAPPPPPPPPPPPPLPPPSSPVPSSAPAAISTVSAAARSVSAPNQEPCPAAATTLVTTTTVYVKGQTPSSTTPVVVAAALEPSTVMVTVTTHVPAPSKRALRPRYGARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGY2</accession>
    <name>A0A367LGY2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5646</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGY2"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI13659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="104" mass="10752" checksum="A8E0C8C8E3C73A04" modified="2018-11-07" version="1" fragment="single">SLTYPTFLPSYGPYGPYGRSRCSLTYPTFLPSYGPYGPYGRSRSAVTYGGLGPAAAGPASRSLTYPTFLPSYGPYGPYGRSRSAVTYGGLGPAAAGPASPLPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LH00</accession>
    <name>A0A367LH00_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_8211</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LH00"/>
    <dbReference type="STRING" id="1330021.A0A367LH00"/>
    <dbReference type="OrthoDB" id="4500315at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000396">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000009">
        <property type="entry name" value="MFS multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF4">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="508"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="552"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="597"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="624"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="669"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="691"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="153"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="25"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="81"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="357"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI13698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="730" mass="79778" checksum="0B85A581D0A9A258" modified="2018-11-07" version="1">MSSEEDLKPPPSRWKSPRALARHLSSVWSGQNGSSTEKPARSKWSMGVLNDKQTDEVPGSVLLLASDRNEPLGLRNMHARTSHSSLPTGLSPSPGPNSRPQSGPALPRLPSQRQLEPIDEKKTTSDGAIILEPQPDDSANDPLNWPAWRRDTALLSLGFYCMIGGGITPLIAAGFTDVAADFHVDVEIVSLTTGLYMMGLGLGSVLASPTAILFGKRPVYLGSAIVFIVTCLWAAWSPSFSSLLAARVFQGVAISPVECLPSATIAEIFFLHERAYRIGIYTLLLLGGKNLVPLVSAAIISRFGWRWVFWIVAIVVGFGFVLLFLFVPETFWDRTPTKRTSTRGSLLRRLSSRLGVHKPDAPSVAGGKAVTRPSSPGAAARQSELRVGFSPDMRGPSEGGSGVQSPKTPDWVVPPPSTRPDESPQMPPASPYTHVSARGSALNVEYAAGGPNLDTEKIPASALKAPPKVQAYTYNLRRQPAQTFVQQLKPFHGRLNNDKWLKVMLRPFVLYAYPPVLWSAAVYSCSIGWLIVISETMAIIYRDPSIYNFSALQTGLVYISPFVGGILGTGVAGKVSDVIVRAMSRRNGGLYEPEFRLIMVIPVLVTTCIGLMGFGWSAQDKDPWIVPTVFFGVLSFGCSLGSTTSITYCVDSYRQYAGEALVTLNFSKNIFHGLIFSLFVANWMAKDGPRLVFIWLGVIQLLVLLTTIPMYIYGKRARMWTARRNLMERF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LH03</accession>
    <name>A0A367LH03_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7978</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LH03"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI13679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="164" mass="19143" checksum="F985C87CD9D21F47" modified="2018-11-07" version="1">MECWNALIDDAKAPPAPFRVGTLRARGKQLWVHIKALRHHSGGSFIRWKNRIKQTVASRRLEPWRASKLAPRRMFVARQRRIEARYACTKGRETCKDFKFIVLMVDWGRLGRRTTNPSFESFLRLTLLAMFVQHMCLPDESGCYLDKQSDTVQCNSPWAMGFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LH14</accession>
    <name>A0A367LH14_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anaphase-promoting complex subunit 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cyclosome subunit 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_8218</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LH14"/>
    <dbReference type="STRING" id="1330021.A0A367LH14"/>
    <dbReference type="OrthoDB" id="2504561at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037679">
        <property type="entry name" value="Apc5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026000">
        <property type="entry name" value="Apc5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12830">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12830:SF9">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12862">
        <property type="entry name" value="ANAPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 5" evidence="10">
        <location>
            <begin position="317"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="127"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI13689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="821" mass="91797" checksum="5886DBBF9D92DDAA" modified="2018-11-07" version="1">MARYLNPAKIGLLALVELYAEEAIPSDAILPVLSFLTAHTLHQSPSSSSSSSSSVTTPRWNKAERTANLVVSIKDFERLLSEYPVVKGMPGRKLWDQFLAKLWGIDSLDALHSFFASIPALLKKTREESSKERGGDEQEEAEAAAAAAAEEEDGKTKIKLSRNSPLGAFVRRSKTEFHRLTFEQSTQLWKSLIRYRQPTSQSYLRHRQPTAQPYVQRGTPSLEKLTFDNVLVRAAASGEWDADGVERLVAVAYGTHVLAGDDEGEGGTVPVSTDDVEALVEFQIQRMQKYGDRVPVEIQQQFEHLLRDSFLIPSLTHYLSFLNAWRAGDYTTAFDYLHRYFDYTMQYRDRLFYQYALMNLAVLQADFGCYREAVSAMLETVSTARENRDMTCLNFALNWLFHFGRAHPELVHDLESHSMLGAGKESLAFLRVKAKESAMWTLWSSVLLAESKMALVNGDSVAKSVENMVRSSQIIVERNLKSMFGSQLSLQAALWTRLGLGHLSSCASETFLRCHARNSVFDDELKHTCRIAFALAQRGKYDDALHRLDSLDENSLRSWKPSQYWLKHRAIVKLKRDLCHNNLDAAGRLLDQLLQSKADDLEPDMALVVDSLHIDYLERKGDLQAALAEIDALMVRLRDDGRDVAMGIKLLLLKTALLDRCGRPLRAFSAAVRATNMAWRARLLSCLWQAVGALSTMLVSLAEFDAAVRLLTAVVPRALECDAAAPAAQLYSVLADAHMGSAGNMEPKSSRRTECLKRALRAVQKALDHYSAVEDVERQCETMAKKAMIMKLTGEATLAANYAAAYVELRKRAEALSLDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHT3</accession>
    <name>A0A367LHT3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal RNA-processing protein 40</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_8304</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHT3"/>
    <dbReference type="STRING" id="1330021.A0A367LHT3"/>
    <dbReference type="OrthoDB" id="340500at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22526">
        <property type="entry name" value="KH-I_Rrp40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000127">
        <property type="entry name" value="Exosome complex component RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000073">
        <property type="entry name" value="Putative Exosome complex component RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049469">
        <property type="entry name" value="RRP40_KH-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041054">
        <property type="entry name" value="Rrp40_N_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15985">
        <property type="entry name" value="KH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18311">
        <property type="entry name" value="Rrp40_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21262">
        <property type="entry name" value="RRP40_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Exosome complex exonuclease Rrp40 N-terminal" evidence="6">
        <location>
            <begin position="27"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="5">
        <location>
            <begin position="156"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF15985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI13970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="26524" checksum="7EE181A47697ACEB" modified="2018-11-07" version="1">MATDSVFVLPGDKIDNSLIPTHPKKQLRLGPGLRHVPPNAILPSLAGRLVTDQRKNAMHVETSAGRYLPRAGELVIGTILKTSADLYHVLLTEYTAPTLLPQLSFEGASRKTRPILAPGALVYARVSLAEKHMDPELECVSATTGKSDGLGPLVGGMLFHISLGMARRLMMPKPAADGKLVVLEELAALGLQFETATGRNGRLWVDSEDVKTVIAVGRAVQETDENRLSIADQKKLVKRITKPWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIC9</accession>
    <name>A0A367LIC9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIC9"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="78" mass="8866" checksum="1811AC52B230A60B" modified="2018-11-07" version="1">MEACRTWASHEMWAINEALHRGMTAGKKLPCYCRHPGFSSLARRSGGLHSAAIEDEEEEEEEEENEPTRAHGQQRGRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIH4</accession>
    <name>A0A367LIH4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_6191</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIH4"/>
    <dbReference type="OrthoDB" id="4495335at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42041">
        <property type="entry name" value="DNA ENDONUCLEASE ACTIVATOR CTP1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42041:SF1">
        <property type="entry name" value="DNA ENDONUCLEASE ACTIVATOR CTP1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="227"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="326"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="390"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="472"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="56"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="253"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="328"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="392"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="493"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI14228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="503" mass="56265" checksum="5C3946CB9B6BA183" modified="2018-11-07" version="1">MDPKASFPNGVPLQTTTAERMNRSDGSVHDKISQFNSLSIAFQSKQLERKTADAALKRALVGREEAEAEMRRLREETAELHRALDEGRERERKVGERLETVMENYGRAKETHAHTQALWEKEIRRARKENFKCQSAMVKLQEELKSTRWTTKSLEEAVEAERCRVQAREEEAFSTRYQLVGTQEKLDEALCRIKLVEQERDAFKLASHHEQLARVAAEGRIPLPKVASADYDEGDDEFASPVKNNRKRRRAASSSSSSSSLLPTSSSAVGETEREELLLWREWERHRADRATELVEFLEVECRLGCCSSSSSSSSSSSAAAAAAVKKTRLESRQTQTEARDVKEEQESRRKRRQPVEPPSFALQRSSLESLLEAPQQPALIRCVSPILRPHTSTTTTTTTTKIPLRDDHAKRPSSSLLPLGPRTPSSSSNPNFTTAATFDRENPALTPTMTREQALATIRERRGRVRSAAAAAAAGAATPKRIGAERRYMSAPTPTSVARSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIJ4</accession>
    <name>A0A367LIJ4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIJ4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="65" mass="7418" checksum="402F2DC7EED749F5" modified="2018-11-07" version="1" fragment="single">LSDSGYLYTFNLFFTAFLFTFCPTNYLIRTQTDLLFPTKFPLSATIGNVKKYSFAKLSGSGNYTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIK9</accession>
    <name>A0A367LIK9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Diterpenoid pyrone biosynthesis cluster protein C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_5999</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite biosynthesis; terpenoid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIK9"/>
    <dbReference type="STRING" id="1330021.A0A367LIK9"/>
    <dbReference type="OrthoDB" id="18170at2759"/>
    <dbReference type="UniPathway" id="UPA00213"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008412">
        <property type="term" value="F:4-hydroxybenzoate polyprenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016114">
        <property type="term" value="P:terpenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13959">
        <property type="entry name" value="PT_UbiA_COQ2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.357.140:FF:000008">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1780:FF:000001">
        <property type="entry name" value="4-hydroxybenzoate octaprenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1780">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030470">
        <property type="entry name" value="UbiA_prenylTrfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048:SF28">
        <property type="entry name" value="4-HYDROXYBENZOATE POLYPRENYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PRENYLTRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00943">
        <property type="entry name" value="UBIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="80"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00075214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI14249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="279" mass="29644" checksum="693A787500F0E8C4" modified="2018-11-07" version="1">MLTPVAPVSSVISYSCLFLAGALIMRGAGCTINDLWDRNLDSNVRRTRLRPLARGAVKPFSGVVFTGAQLLAGFAILLQFPLPCVVCGALSLPLVAIYPLAKRVTYYPQFVLGLTFSWGAILGFPALGLDLIENGAAVTAASCLYASNVAWTVLYDIIYAHMDKYDDAQAGIKSIALKHGAESKKILAGLAMAQVSLLAASGLASGAGPVFFIGSCGGALLSLAVMIHRVNLRSVQNCWWWFVKGCWITGGTISAGLAVDYMICIGKEIECDRETSTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIP7</accession>
    <name>A0A367LIP7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_8058</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI14132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIP7"/>
    <dbReference type="STRING" id="1330021.A0A367LIP7"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000011">
        <property type="entry name" value="Vacuolar calcium ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF20">
        <property type="entry name" value="CA(2+)_H(+) EXCHANGER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="224"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="475"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="513"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="537"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="164"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="411"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="49"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI14132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="567" mass="61504" checksum="330623CA189E6A29" modified="2018-11-07" version="1">MASNVPFNHFRNKRQAHAVSRASSEAWNPFRHVWGRERRVQTWAALEEEQQHHGMTYSATAPTARRQRSEDDEASQAKTPSSVDAEATAAGLRNRKPDDAATDEKKSEAGDDKKGRFLRRVEPKTPFTLSNQLQRTFLNSWINVLLFAAPVGIAINYVPSIPRVAVFVVNFIAIIPLAALLSFATEEIALRTGETLGGLLNATFGNAVEVIVSIIALIDGKIQIVKTSLIGSILSNLLLVMGCCFFFGGLRRQEQHFNTVVAQTAASLLALAAASVIVPTVFDAAQNTPVSKVAALSRGTAVILLVVYAAYLFFQLKTHQTVFSEESQKVPAKPWGIRSSSSPPPGAIHQALAIPGSLMGQGVQEPSANERLSRMLLNPLRYSKKGDLLDGTVDDDEDEEEEEAQLHFGVALATLTISTAIIALCAEFMVDSIDAVTRNGALSEEFLGLILLPIVGNAAEHATAVTVAMKDKMDLAIGVAVGSSMQIALFVIPFIVLVGWGMHVDPMNLSFDFFQTATMFMAVLLVNYLIGDGKSHWLEGFLLICLYAIVGVCAFYYPNSAAEREGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJ60</accession>
    <name>A0A367LJ60_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">YAG7-like dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_6102</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LJ60"/>
    <dbReference type="OrthoDB" id="10262720at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034663">
        <property type="term" value="C:endoplasmic reticulum chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10230">
        <property type="entry name" value="ASKHA_NBD_HSP70_HYOU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058602">
        <property type="entry name" value="YAG7_dimerisation_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF3">
        <property type="entry name" value="HYPOXIA UP-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26434">
        <property type="entry name" value="YAG7_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YAG7-like dimerisation" evidence="6">
        <location>
            <begin position="164"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="256"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1042"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1187"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1261"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1379"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1408"/>
            <end position="1441"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="108"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1069"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1079"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1098"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1191"/>
            <end position="1203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1276"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1303"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1408"/>
            <end position="1425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF26434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI14468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1441" mass="155354" checksum="6F8DB2D190D5AAFD" modified="2018-11-07" version="1">MAVQAAASKKKVAKATESAKAPELAKAPEPAHSPTPSTASGVGDKSQDDGNEMPIIKDLQKNIRNLTKKITNASKTDSLLAQHSNKSLDDLVASKVINTDQKAQILKKPALQEQLAQTEEKLAQFRQLNDHYRLRAKMDKAEWEKSLEKAKDEAMAETRQNFDKSLRDHLLVLSQFLRLAAYRREEAKDLNSDESQAIEGVLLAIYSGDESAVGAMLKLIEGSKDSILSVPGQPLETTFASVKALAQDYKTPFYSETAPAVEPEPEKEVASVDPPAAADSPPVANAAAAEKDATESASVNGQDKTEPLANGTAHDSTSDDAVNAVTTAHSEGTHDESSVHDWVNLDHPRDSPEKEEEAAAASQESPVMANNTRSWADEQPDAVVEPTTDFTKFSATEADRSANPARGGEAALRAGAGAEEKAGVGGEGAAAAAMAECPVLVSSSSLSSRVRDTMAVSPRRWRPAMALLLGAMLMLSSGVAGAVLGVDLGTEYIKAALVKPGIPLDIVLTKDSRRKETSAVAFKPPRSGVKEGVFPERVYGADAMAIAARFPGEVYPNLKTLLGLPMEDEIVRDYATRHPALQMTPHPSRRTAVFRSKTVPETQDAWTVEELLAMELQSVQKNAEAAAGDGTSVRSVVLTVPPFYTVEEKRAVQTAAELAGLKVLGLMSDGLAVGLNYATSRQFPNINEGAKPEYHLVFDMGAGSTSATVMRFQGRTVKDLGKFNKTVQEVQVLGAGWDRTLGGDALNYLIMDDMISRFAAASGGSVTAEAVRSHGRAMASLAREAERARQVLSANQETSSSFEGLYDDRDFRYKLTRAEFEDMAEAYGQRVGQVIRNAVDTSKIALEDLTSVILHGGATRTPFVQRALEQAFGSADKLRSNVNADEAAVFGAGFRAAELSPSFRVKEIRISEGPMYPVGIKWTANSGKELRQRLWTATSPMGGPAKEMTLTEQKDVEIGFYQQVASEAMDTKTMKTKNLTATVAAMKEQYPSCIETDVAFRLALGLSSENGEVQVVKAAVECEAEVPEKGFVDGVKNLLGLGKKDQKDQQPLTEGGENMESQSTEGSEEDMKTDKDESTSTGTETAESASSAAAAEAAEAKSSDEVKPEGKAEVKKRREVVSIPVAFTLENAGPPSLTKADLTKIKDRLKAFAASDKARMQREETLNQLEGYTYKVRDLLEGEAFTSMSTEQERSKLADKASETSDWLYDGGSDATKEELKAKLKMLQDLVAPIQTRVDEAEKRPTVVSLLRASLNQTGQMVSGLRKQLSEHEQQSSSASASATPSSGFDGLEDSDSAPASKDSADKPLFKKEDVDEVEALRDSTAKWLDDMESRQAALPPTADPVLLTREMTEKKLKLDKAGMDLALKGVRSFESKAKKAGKGKVKFSDGSGKMSDEELERMMEKIKTEATDKLKRGKDGGGERRRMKGRGRRTIEGMDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJA5</accession>
    <name>A0A367LJA5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Small ribosomal subunit protein mS37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the mitochondrial small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the mitochondrion-specific ribosomal protein mS37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJA5"/>
    <dbReference type="STRING" id="1330021.A0A367LJA5"/>
    <dbReference type="OrthoDB" id="2210at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017264">
        <property type="entry name" value="Ribosomal_mS37_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28066">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN MRP10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28066:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037706">
        <property type="entry name" value="MRP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="92" mass="10207" checksum="0B6B31E40218799D" modified="2018-11-07" version="1">MVSRKKPMRLPPLKVLRVHSPKRSTENPCLSLMTAVLACWASVGFNSDGCAAIETQLRLCMDGPPPPPAPTNTINYHLGRMKKYLINPGRHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJD5</accession>
    <name>A0A367LJD5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Abnormal eversion of vulva protein 20</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">L249_6588</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">GTP-binding protein that functions in embryogenesis, cytokinesis, germline development and microtubulule cytoskeleton dynamics.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJD5"/>
    <dbReference type="STRING" id="1330021.A0A367LJD5"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04154">
        <property type="entry name" value="Arl2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000981">
        <property type="entry name" value="ADP-ribosylation factor-like 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045873">
        <property type="entry name" value="Arl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044612">
        <property type="entry name" value="ARL2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45697">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0217">Developmental protein</keyword>
    <keyword evidence="9 15 17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0519">Myristate</keyword>
    <keyword evidence="8 15 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="21"/>
            <end position="28"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="28"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="123"/>
            <end position="126"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00055307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RCI14534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="181" mass="20627" checksum="F46F2EA5842B6187" modified="2018-11-07" version="1">MLSILRKARLRDKEMRILMLGLDNAGKTTIVKSIMGEDVHSVSPTLGFIIKTIDYDGYKLNIWDVGGQKTLRSYWRNYFEKTDALIWVVDATDRQRAEDCRTELEGLLQEERLAGASLLVFANKTDVEGSMDEGEICEALQLDKIRTHQWHVVRCSAVMGTNLDEGIAWVVAEAKKQLFLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJN7</accession>
    <name>A0A367LJN7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6976</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJN7"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="72" mass="7942" checksum="A0F2B66074BA789A" modified="2018-11-07" version="1">MAGKCKKLFFLPSLPARLPSHSNTINPPLQSVPHKQKQQGWIDKPIIKPVRLTPQVPASSCNAGCEEVLLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LK08</accession>
    <name>A0A367LK08_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LK08"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="106" mass="12499" checksum="09A5AEB406A37576" modified="2018-11-07" version="1">MSNQGVDYVIEKKKTNHVIVVLSNKVEADNELEVVLYYSTMTWLYVTPFRSTTIEVGRYDRYWYSASIARADRCIARRSLPTVGKPSFFYRQFLRNKDLYVSIRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKD2</accession>
    <name>A0A367LKD2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_6700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LKD2"/>
    <dbReference type="OrthoDB" id="4925214at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000845">
        <property type="entry name" value="Nucleoside_phosphorylase_d"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF10">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01048">
        <property type="entry name" value="PNP_UDP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="3">
        <location>
            <begin position="657"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="348"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="356"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI14837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1363" mass="153191" checksum="302B2428BDC0EDD8" modified="2018-11-07" version="1">MDHVKPTRRVFRRPSHRRDFQIAIICALTLEYDAASLLVDEFWDQDDAEYGRASGDTNLYRNGRIGTHDVVLMVLPSMGKALVAGSAASLRTSYPSLKLVFLVGICGGVPSSGSHYALLGDVVIGEAIIQYDFGRQYPGEFLPKEAMERSPNKDIRTLMAYCKSRYGREDVRTNAAICLKAIQDAALNKYYRTDYLYPGLADDKLYRATYRHKHRQPSCDICSGETDRVCSEAAKASCADLGCEEKELVHRKQKRHHPCPDILIGRLASGDTVMKSGQHRDQIAKQHDIIAFEMEGAGAWDELPCVVVKGICDYADSHKSKEWQPYAAATASAVVKAILMRYTVTENPHLQPLPDNDEKLAETEAPDHGNSSLSSMVHRSAGQTLNDAILDFQDILTPAERRHLRTMEAVPGHDAVLVFTAQLDLRNRNRRGPSIASRLYSILQSVRDFADVAENSGKNTSWQPGTAARVWGIVKLTMLTVFDSVVYYGLLSKVLMNVGRFCPQVAEYRVWYSTSARIQKALCNFYASLIFLDALWETLELEFHPDIEDIRRQSSDVQEELSLARARAKYQDQQLNKTRGTWKLGTLFSTTRKEQAAQVRTSERQAGQRRQQLMDSLSTHDYLTPLKQSRRKRYSGTAHWLSRTRQFSRWMDGVDSPLFWCSGKIGSGKTVLTASVIDEILTERHNTGIMIAFFFVKFDDRQSTRAETIVKSVLRQVLEQFALTNEVEDVLEKAQTPLAELGKLTNVFQHALTPLNRLYIIIDGLDECEKPDRRELLETLSSLAALGSKISIFLAGRDSITTEINKVFPAHHHVTMSSSLAQPDIARYIEGAVQDKLESEELIVRDPSLVDEIKLALKRGAEGMFLWVAFQLFELCSKHCDDDIRRTIGNLPRDLTETFDRALERIVSQGNAKVARQAFLWIAAAKQPLSLEELGEAMFIEIGQQFSQPERFSNDIYRISSWCENLAHVDEERQIVQFPHETVRQFFVSRFSDFHIDLSEADHYIGEICVTYLNFSNFKTTLARRFQPLMPFPPKAIAQAALGRGWASLAVKDRRSSHSQKDRDCIDINLASFQRDNGQTTREKLQGNFPFLRYATVHWILHTTGFRRNKSITYPLWEKIITQGHDLVQVPWGSEPFRADSETISTWSYEARHYAMMQLLDSRRGLSDSRKTTMLMDSAGRGDLTMIDILLGDGQLPAARLRGVCQVAARSGLFHVVERLIAAGASANDALNEAARIGNVEIVQELLHAGFDTSSALEAAARNGHVEIVDKFLNAGVAPYSALCEAALNGHLHVVERILVAEEELRSGLGGEDEGRDIERLLASGSCLRQASEAAWKRGYLEIVDVLQAAEVNVEVQMQALLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKY4</accession>
    <name>A0A367LKY4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_6828</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKY4"/>
    <dbReference type="STRING" id="1330021.A0A367LKY4"/>
    <dbReference type="OrthoDB" id="3214149at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000201">
        <property type="entry name" value="C2H2 finger domain protein (Gli3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000031">
        <property type="entry name" value="GLI family zinc finger 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043359">
        <property type="entry name" value="GLI-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45718:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR CUBITUS INTERRUPTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="183"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="361"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="88"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="378"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI15095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="392" mass="43220" checksum="0EAE84EB415A1FC2" modified="2018-11-07" version="1">MPRHHHPYPPPDSPLSSIGSAEPYEYGETEEEHDDDYDEAASLRPSKRQKVKAGSTTTSSAAAVAVVVPDVVEPETVPEPDALEGMSDVSSDTSGDIPSSPINARLDEEDFQEQVTVCDWDGCPVGDLSNMDRLVEHIHNSHIENRQKKYTCEWKSCNRKGLPHASGYALKAHMRSHTREKPFYCYLPECDRSFTRSDALAKHMRTVHETEALRPSDPVPKSMQPTTKASKLKIIIKTPQSHGAAAAAAAAAADDGADGSANGEVFNAEFFTVLTADLFSAEELAHPVDKLYRKCYWEAKWADEVGEALRKECKEWEERYYKEWLEKEALLSQVIQSEVDWHERRQAVLSGTADVDLSTIVDEPEPEPVQANGVEGDAASSPVASAAQVTDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LL67</accession>
    <name>A0A367LL67_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">14-3-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_6967</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 14-3-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LL67"/>
    <dbReference type="STRING" id="1330021.A0A367LL67"/>
    <dbReference type="OrthoDB" id="10260625at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11309">
        <property type="entry name" value="14-3-3_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.190.20:FF:000002">
        <property type="entry name" value="14-3-3 protein epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023409">
        <property type="entry name" value="14-3-3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000868">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00305">
        <property type="entry name" value="1433ZETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00101">
        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00796">
        <property type="entry name" value="1433_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00797">
        <property type="entry name" value="1433_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="5">
        <location>
            <begin position="3"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="259"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000868-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI15140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="288" mass="31659" checksum="067D33DFF6137200" modified="2018-11-07" version="1">MGHEDAVYLAKLAEQAERYEEMVENMKIVASEDRDLTVEERNLLSVAYKNVIGARRASWRIVTSIEQKEESKGNSSQVTLIKEYRQKIEAELAKICDDILDVLDQHLIPSASTGESKVFYHKMKGDYHRYLAEFAIGDRRKESADKSLEAYKAATEVAQTELPPTHPIRLGLALNFSVFYYEILNAPDQACHLAKQAFDDAIAGMLAVDVSSLTVSDKSTAIELDTLSEESYKDSTLIMQLLRDNLTLWTSSEAEAGAAAAGQADSTAKEDTTAAAAPAAADETKAAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LM22</accession>
    <name>A0A367LM22_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PDZ GRASP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_3595</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LM22"/>
    <dbReference type="STRING" id="1330021.A0A367LM22"/>
    <dbReference type="OrthoDB" id="3318at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.42.10:FF:000026">
        <property type="entry name" value="Golgi reassembly stacking protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007583">
        <property type="entry name" value="GRASP55_65"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024958">
        <property type="entry name" value="GRASP_PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12893">
        <property type="entry name" value="GOLGI REASSEMBLY STACKING PROTEIN GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12893:SF0">
        <property type="entry name" value="GRASP65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04495">
        <property type="entry name" value="GRASP55_65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51865">
        <property type="entry name" value="PDZ_GRASP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ GRASP-type" evidence="6">
        <location>
            <begin position="27"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="PDZ GRASP-type" evidence="6">
        <location>
            <begin position="116"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="256"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="267"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="308"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI15485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="328" mass="35480" checksum="CBF705D22B2BD79B" modified="2018-11-07" version="1">MFNALNRFMSRLDGGDSNARQHERGSFGFQVLRNTNLDLSVEPWFDFIVGINGRPLDDPNPSLFAREIQNCAGATVTLGLWNAKGQRTREMHIAVPAESASIGLSLQYAPLALAANVWHVLDVAANSPADHAALLPYSDYILGSPEGALHGEAALGELVEDHIARPLRLYVYNNEYDVTREVTIQPSRDWGGEGALGCVLGYGALHRLPAPLSEPVHAPGETLFDGDVSEKTKVVESTVPPPPAGGDYLIPAQMVDSSSAGAPQRKGAAKKKERHGQGHNRLMDDYFKEEEEKSRELDNAPKSKGTSVPPPPKTPRAPPEPVQEGGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMR9</accession>
    <name>A0A367LMR9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_3233</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMR9"/>
    <dbReference type="STRING" id="1330021.A0A367LMR9"/>
    <dbReference type="OrthoDB" id="5571888at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14810">
        <property type="entry name" value="bZIP_u1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000031">
        <property type="entry name" value="BZIP transcription factor (MeaB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37616:SF2">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37616">
        <property type="entry name" value="BZIP TRANSCRIPTION FACTOR 60-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="252"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="326"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI15743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="525" mass="57473" checksum="99BA826401E0D85A" modified="2018-11-07" version="1">MTGGDDDDKPFSMSESASISTVDFDALLDLSEFDNNYTSSSLSPTPTAKAAFSSPISIPVTTPGLPASTQQSLSGPSHKYGLYRQQTGFVPGAIANTMAVNQSANAGYQDYYISSLTPDTQPFMFNTSPSLLAMDIDPDPLSTVNPNNIENDGLASPASTSSNVGRLYPGAHSQAALAKANAQQKQRVKDPQPADSLVEQKIAQVLNSMRATPAAPESSGRAAHTSLPRSRKDEDDMDEDERLLASEEGKKLSSKERRQLRNKVSARAFRSRRKEYISQLEAEIATKVNDNNHLRAQNRMLFEENKRLSDLTRMLLSSPSFSNFLDHLSTNPQVKSEPQQEEQLPADAPKDSNPRNGQQSHQEQIGMVMVPEHTVDLPQLSLDNYNFQPQVFVVVDTPQVDISVLSGKTGDFVDDPVQEGDCKVSMPAIERPDESLKVTQSGASDDDEFERDPEYALFNSEPVRETNDDDGSGIVSGIESNTLSSDPHVDTEPEEVAAQAMARVKRIRAELEPLVSRLELLTRDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNI2</accession>
    <name>A0A367LNI2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_1950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNI2"/>
    <dbReference type="OrthoDB" id="4779840at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI15951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="91" mass="10594" checksum="AB05522D32E2BA95" modified="2018-11-07" version="1">MLRKDLLLPNLILKNRLRGCILNLSVAIRDCLVKLFRIETLSLFRNSGNHSTPAERLGLEPNTENYKVDRILNIRKIKRSKGIARTEYLVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNJ6</accession>
    <name>A0A367LNJ6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_2991</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNJ6"/>
    <dbReference type="STRING" id="1330021.A0A367LNJ6"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="36"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="148"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="464"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="464"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="508"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI15990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="574" mass="65842" checksum="CA1ED1B15D2974FE" modified="2018-11-07" version="1">MAIPGQEKPERYLILRDRLAGDQDQKLVPIWDDEVLNIGRHPQSNPRIGDGYNTLVSRKHCEVYVVVYDEFNSSVYVRDRNTRNGTFVNNVRIATGSGISPSHLLQDGDMIEIHPNWSMTFHDRKDFKSTSTTEIQDKECKLFQEKYTISQRCLGQGAEGAVYLASEVETRKQLVCKIVDLSKIKGKDAVDSIRRKLQEADVLRQLHHPNILRYVDAVVSPHSLHVNTARKSQVFNQLLTWLQIHIHRAGYRSEFEARVIIRQLVQALDFIHKKGVIHRDLKPENILLAYSPNVTCHRILLSDFGACAVPRRSRMLTHVGTTNYQAPEIQDKYEPHTASVDMWSLGIVTLTLITHGMDVSLKGLDRMAQPEIQQFLKDDALQPGYFSQHCEDFVIRCLQTRPSSRMTAAQARHHKWLCRPVKHLEHFRELERIARSNWTTSHKVRPMPLQLPDVTDEHFVPSEGRHLVGTRPKDTDENSQFFDRSARSDDAPLPPQNAADKSSWDPKCNSSVATIPPVQQSERKSERAVVDKRGLIIEQLRRANVKFLPEIPTRRATLSTVSTSDGRQKRQRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNV6</accession>
    <name>A0A367LNV6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CUE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_3262</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNV6"/>
    <dbReference type="STRING" id="1330021.A0A367LNV6"/>
    <dbReference type="OrthoDB" id="9942608at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14372">
        <property type="entry name" value="CUE_Cue5p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000064">
        <property type="entry name" value="Similar to CUE domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041807">
        <property type="entry name" value="Cue5/Don1_CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16461">
        <property type="entry name" value="TOLL-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16461:SF5">
        <property type="entry name" value="TOLL-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="83"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI16124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="429" mass="45994" checksum="22794A431110FCDA" modified="2018-11-07" version="1">MSAAAGTASNAKAATADSGAESPTTARPLEMDDDDVQETTGIVGEDGNVTTASRQKTTAPTAAHSTPLDAASPPQPPPKPVSQTEQNVVTLKEAFPTVEDAVIRAVLRASGGHVEPAFHALLEMTDPEAAKNEPRDDTPTPQQPPPQVHGRGGMSQVEADERYARQLAEHYDNVGSYEARTSNRSRAAPPHLSPSMNDDDREHSFIDDDLPVIRENLRKGFLDTQTKVNGWITNLKKRIEEGFDEYDGTTTGPSLPPRRQGEASRDATRRSGDYHRYDADPEVLSDDFAGMGFAADGTSSTGPAKKTTSPQTADGRRVGFKPDAEEINMYDASPTTTAKDPMSAAAAKASKWQPLSNVEPKPMADNDPFSLGDSEDEKETKDKPKEAKDNKPMDAKADDGDRVKTAAAEAMADSLVDAPKIGEPEDKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNV8</accession>
    <name>A0A367LNV8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_1838</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNV8"/>
    <dbReference type="STRING" id="1330021.A0A367LNV8"/>
    <dbReference type="OrthoDB" id="189226at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036149">
        <property type="term" value="P:phosphatidylinositol acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07990">
        <property type="entry name" value="LPLAT_LCLAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032098">
        <property type="entry name" value="Acyltransf_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983">
        <property type="entry name" value="1-ACYLGLYCEROL-3-PHOSPHATE ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10983:SF16">
        <property type="entry name" value="LYSOCARDIOLIPIN ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16076">
        <property type="entry name" value="Acyltransf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="393"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="6">
        <location>
            <begin position="137"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="7"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI16089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="419" mass="47329" checksum="B75257F4DBA69B56" modified="2018-11-07" version="1">MELSDPSEPPVPTPPPPPLLSTDADANRSPITSHPSGKEAYSRLVQVMRGIGLAAYFLLCSGAIIFAQVVGLPLYWIDRDWFYAYVAYTKRSFALLAASVTRIWGPTTMRISGDASVAGQIKATADGGVEFAFPERLVLMANHQGTWAQIYTDWIYLWWIAYANRPGMAGHIYIILKESLKYIPFIGPSMMFYGFIFMSRKMATDQPRLAYRINKLKKKKTGADGRPYLDPMWLLLFPEGTNLSTNGRNKSAQWAAKQGLEDPEHVLLPRSTGIFFCLNQLKGTVDSVYDCTVAYEGVPRGKYGEQLFGLASTYFQGRSPKSVNLYWRRFRLAEMPLHDAGEFDVWLRDQWYRKNELMEAYLGTGRFPALTEGPVEYVEAPVRTRRRLEMLTIFAVPGTVLLLLGMVARVVMVVVMVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPC9</accession>
    <name>A0A367LPC9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPC9"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="121" mass="12747" checksum="4475054DBF0D80B9" modified="2018-11-07" version="1" fragment="single">MGKGERRHVMLPAADAHRPIQPRLPTNPTSGAAVGVEGDRGCASLLLSSMYGHLHLHLNLHLLSSLFPNSIKEIAGPDGAPSVSSSGQFNSCPCPLTLVPRAQEASSTDGTASNEEHTTKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPD0</accession>
    <name>A0A367LPD0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_1858</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPD0"/>
    <dbReference type="OrthoDB" id="4928085at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI16293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="194" mass="21275" checksum="E2732B93F5C389EE" modified="2018-11-07" version="1">MNLHQPMWANDFAWPRVFHADGSDKSLGRNWEFFASKATKHPLLTRSETTTAIEIQQLFVLRYKTWADALTLHLPFPSRNMKLLNNLLLMGALATSVLSTAIPEMAEEAAVEEGVSTLEDAPGGVFAEARAVRSIHHHSRIYEDAVASVDLTAAIARDPCVFVLAEALDVSALADKGRNTSKCGPNLKALIHDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPH4</accession>
    <name>A0A367LPH4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_1854</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPH4"/>
    <dbReference type="OrthoDB" id="3364175at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="38"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="175"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI16291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="718" mass="79260" checksum="DF0D456DF418883A" modified="2018-11-07" version="1">MPSIVFTCLDEASTKTKTTTTMDRTDRPLTKRLRASLACNGCRQTKSKCDGARPICERCTRNGASCVYSQSGQDKRMQRQDERRANLALMSRVKELEAKLAALSPSCDEIHVDKASVTNSEGSADAIATGLFDHPPANDTGYFGSSSNHAFFFSLSTSIENVSRRDGLGQEPARHMPPPDPPLALAPPPMTDRPGDDSFPELKVAVAWVMRFFHTVGAVVIYLDESDILAEIDAIGPRGWQSRSPSSQALLSIIFAHALNTLEERSPEPFYRRALSLLDDKAVHNPTICALQALLLTSRFQQNTQRSMESWAPHYLAVRVSYQLGIHAPASYKHLSIHDKELRSRLWYAVVNQDRILTASLARPCLIPLQHVQGEISDFLDAARPGKSTEMNCSEESVAFFRRNISLHQILGATVDSIYSSNINMTSRLPLGDLLAKTMDLVWKLDEWRQNKAPAEAFVSAVDMGQWPAEAFQTQRFNIVTTIFFSRTQMLIHGGLLMRVLERVSGTPDQDASSTAVHDASLSLLRNYLRDLQQWLSFIEVILNHERSFLTCNAVWWTSNYMMVSTCIHAFAFWLLADEMRSSSLELEQFLRSALDTLKRVGGSSIMSRKAHRCMERYLHCLKSIRASGTDCASVHSSVAMSDQTEGAAAAAVAAAAAALPPMPVVTPQWNAGVAPEVFATGGGQMDVFGGMGQVDLMYTGFLGMEQAISDYDAAGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPW6</accession>
    <name>A0A367LPW6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_2292</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPW6"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI16441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="197" mass="23037" checksum="BAC45F1B09012ABA" modified="2018-11-07" version="1">MVDPYSVRDAQHHIYLYTCMGWECRRQLTKEQRPGFGLRIYRLAFFPPRLCVNQAKRTKRGFCGAHQHDMQAMCIRLKLELLPPSSYILSKGRFDGHAGIHNRHETPRQPQLIIVVVDVVDPSSLVKAWTNSRRRPSSSLSRHYYQLRIRNRTRKTKNKGRKGREEEMYIDKRLAIRSPMPGRFGPLPASVLVSRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQ16</accession>
    <name>A0A367LQ16_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">assimilatory sulfite reductase (NADPH)</fullName>
            <ecNumber evidence="4">1.8.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">L249_2660</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">This enzyme catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>hydrogen sulfide + 3 NADP(+) + 3 H2O = sulfite + 3 NADPH + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13801"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17359"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.8.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Sulfur metabolism; hydrogen sulfide biosynthesis; hydrogen sulfide from sulfite (NADPH route): step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.2" evidence="4"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQ16"/>
    <dbReference type="STRING" id="1330021.A0A367LQ16"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016903">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004783">
        <property type="term" value="F:sulfite reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06207">
        <property type="entry name" value="CyPoR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000007">
        <property type="entry name" value="Pyruvate:ferredoxin (Flavodoxin) oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000010">
        <property type="entry name" value="Sulfite reductase [NADPH] flavoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000052">
        <property type="entry name" value="Sulfite reductase [NADPH] flavoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000011">
        <property type="entry name" value="Sulfite reductase flavoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="entry name" value="Pyruvate-ferredoxin oxidoreductase, PFOR, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF109">
        <property type="entry name" value="SULFITE REDUCTASE [NADPH] FLAVOPROTEIN COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="Pyruvate-ferredoxin oxidoreductase, PFOR, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="12" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="14" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="19">
        <location>
            <begin position="697"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00059320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RCI16460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1084" mass="118518" checksum="8CA43A3C1D2FD98E" modified="2018-11-07" version="1">MSSSDPASRRRIAANDDYEDDDDDNPLFFSSSLPFGRLPASLASVSCGPAYVTAQLLVQQVAYRLSDNIYSYSPETFDLDLAVRRWSLDAEPNIHGRLPAVLPLQTRTGAGALALGYVFSPDFPVGRRHVPQTLLAPSGSLQHLRSTLDQLSLLYGLSSPFVAHVAAADYVSGGRLVSDYDTVLRLAEDLGLGLVATSSAYEAQHMSLFSTLLATLIPTVHVYDGIRVARETLRVVDALNESGLADLYGPLATQAQKLNPRLDTAGKVLELLRLFNDQLGTVYAPFEYHGHETPDVVVVAFGSVETQVAKQTLSRLAADGTKVGVVNVRLYRPFIDEAFLDAVPSSTRTLAVLGQVCDEAAVNDGAVRSALHADVLTAVTLSMAFEREPHVVDVKYAPAQAVTPRWLVETLRDVSGGESLLPTNKLSSLVAARQYIFWDVDDSATTHAPDTIGKILSRESTTNVYAHKAYDNLIQGGVVRTDLRASRIALEAPYEVDEADVAVVGDERLLKEVDVLESVAQGGKLLLRLPGFRPDDVEKRLPAGFRRSAHAKGVDLFVVDTSHSPALDKEPLAAKLLLELSFLKTALPSLSAVDVGQRLGDDGHHDLTFLPECVDAVEKCLSKLEVPEAWADCAVAVDGGSQQPALRTCIETNSFVPFQKLEIEPEPALDSWRAAARGLIFKEAYQTQTSLRPDLSVKTATIHVKENRRLTPVEYDRNIFHLEFDLGDSGLTYDIGEALGIHADNDEELVDDFIRSYGVDADALVQVPSREDPAVVEVRTARQALVRSVDILGKPPKRFYEALSEHATDEAERRKLAALGGSEGAAEFKRRSEEDTLTYVDVLDEFRSARPALGSLMRMVGPLKRREYSIASAQAVTPNSVALMIVVVSWVDSKGRTRHGQATRYLSRLQPGAAVTVSVKASVMKLPAADTSPLIMAGLGTGLAPFRAFVQYRAMQKAQGKEIGAILLYLGSRHQREEYLYGEEWEAYLAAGVVTLLGSAFSRDQPHKIYIQDRMRQTLDDIVQAYVRDQGSFYLCGPTWPVPDVTEVLQEAIAAEATAGGRRLDPKKEIEKLKEEGRYVLEVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQ81</accession>
    <name>A0A367LQ81_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Insulin-induced protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_2955</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the INSIG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQ81"/>
    <dbReference type="STRING" id="1330021.A0A367LQ81"/>
    <dbReference type="OrthoDB" id="205546at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025929">
        <property type="entry name" value="INSIG_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15301">
        <property type="entry name" value="INSULIN-INDUCED GENE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15301:SF3">
        <property type="entry name" value="PROTEIN NSG1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07281">
        <property type="entry name" value="INSIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="277"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI16596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="395" mass="42453" checksum="B8369709B65BDE48" modified="2018-11-07" version="1">MAEHGPTIQRPIPRRPFRLDFISATPPPEQGDDVNAENGPTILRQIPRRSFSLDFVSATPPPEDDYSPPTDASLQDLAAACVLDPDAESLSRQKSLLNLTSPTLMGIYASGEVDDTPWHTTPVKPRSLDDATYQLMRHRSRPSNSSSWMEKTPTSTTSAFALTARVALLFLLGSGYGVLVTRLHGGERYGAAHLTDGLVKPGLSCNYIACWGAFGVILGSLLPWFDKMWDDTFGGEADVGEPCGENLGPGTDWALVMRAIAAFAGIVFAIRKLSWVSTLQISATLALANPLLWWLIDRSKAGLFLSAGVGLAGSAVLLSVKPDMMPAPCRALPHVLAGRNMPSAVLGGLASRETVETGIWLLSVLFNSCVCFGNVGRRLVWNGKAGIRGRWGGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQF0</accession>
    <name>A0A367LQF0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_2573</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQF0"/>
    <dbReference type="OrthoDB" id="2142503at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36854">
        <property type="entry name" value="CHROMOSOME 9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36854:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016852630" evidence="3">
        <location>
            <begin position="20"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI16639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="376" mass="40534" checksum="C296C0DBD956B7B5" modified="2018-11-07" version="1">MMMRFSVFALAALIATVSAASGPTFCKCTCFKNSTIIPLGPASQFKTSAPSSPSFLKRSDDPSLSPPAPLDRRSASTSCSECTKAFCLSQGIDFCKEAKEENVVTLCFQRVSNKDRFIVWGFILVTLGLLGWAALKRVVEWRDGRALQRQVDYSRIEDPVLESAVAAAVAYIQSQKSTTSREWRKLSLEVREALRAARARTGRAPAPTPPVCPAAAPPVRPAPAAAPTAEPTATTSTGANPTNEIKKMADKILQEQQTTRLEIQRLAQAVEKIQKHLRDLEPRNEKNGRRDAAPVGAHGGGEKRGEEPGAQRSIVVSRKTDSDVILAGARNVARKRVCNNDEADDSADELAGGAEAAVGRMNKKQKASTVINIVIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQL3</accession>
    <name>A0A367LQL3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_2497</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQL3"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI16743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="112" mass="12529" checksum="822D27D881EB1FBE" modified="2018-11-07" version="1" fragment="single">MGFKLCNGERRGRTHGSLFNNYYPSRGQSNPSLVGIYPPSLETITNPLGQSCWPANRHPSPYHLRPEINLRKGITTKHPTVGESDHIANFWDADPASSPLLFLFFCFSRPGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQW4</accession>
    <name>A0A367LQW4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">4-dimethylallyltryptophan N-methyltransferase</fullName>
            <ecNumber evidence="8">2.1.1.261</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_2701</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>4-(3-methylbut-2-enyl)-L-tryptophan + S-adenosyl-L-methionine = 4-(3-methylbut-2-enyl)-L-abrine + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:34435"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58209"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:67248"/>
            <dbReference type="EC" id="2.1.1.261"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Alkaloid biosynthesis; ergot alkaloid biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.261" evidence="8"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQW4"/>
    <dbReference type="STRING" id="1330021.A0A367LQW4"/>
    <dbReference type="OrthoDB" id="659at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009820">
        <property type="term" value="P:alkaloid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051128">
        <property type="entry name" value="EgtD_Methyltrsf_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019257">
        <property type="entry name" value="MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017804">
        <property type="entry name" value="MeTrfase_EgtD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017805">
        <property type="entry name" value="SAM_MeTrfase_EasF-type_put"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03439">
        <property type="entry name" value="methyl_EasF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43397:SF1">
        <property type="entry name" value="ERGOTHIONEINE BIOSYNTHESIS PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10017">
        <property type="entry name" value="Methyltransf_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018005">
        <property type="entry name" value="UCP018005"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0017">Alkaloid metabolism</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine-specific methyltransferase SAM-dependent" evidence="10">
        <location>
            <begin position="42"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI16836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="358" mass="40782" checksum="3BF0A36461127EBB" modified="2018-11-07" version="1">MGSRALTSPCVGRVLDIGGSEMHEQINDRLRRVLKATYSPQAKPTLPDELLYDDVGLPIWNEIIFTPEFYQTHDEMALLDAHGADIVSRLKPGVTVIDLGAGDTRKVERLLVAFEKVQLPAKYLALDISRASLELNIAYLHRQHSSPKSVVDCAGLWGTFRDGKDYVKGIATPRLFLSLGSVLCNDPWVEALNHLKFWVEIMRPDDLLLIGMDAHTDPVDADKIWAAYHSRGDLYRRFFLNGFKHANRLVGEEWFREEDWAFGAQLESKPTTRHRFFFRAKRDVKLGKIDRVIPEGQELDWFDSHKYNEENVQLMCSKAGLSVLDVWQAPNSQFRQYLLKIKDRDQPEDADSAVAGVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQZ7</accession>
    <name>A0A367LQZ7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQZ7"/>
    <dbReference type="STRING" id="1330021.A0A367LQZ7"/>
    <dbReference type="OrthoDB" id="3941134at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="161"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="470"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="538"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="587" mass="63005" checksum="B0DF24E30CB0E509" modified="2018-11-07" version="1">MEDPWGDPWSTDVPATTTTIDLPAASSAADGYSPRPVTDPWSTEADGWTGWDQSPDPDLRAGPSSPDPWAGVERKSFVEEKHDQGQLDDRVWEPDGADKEPTRRHGTDRDTGRQPSKVAELVDMYDGMARHSSRSSSTKTPVARDDVAVSGTDDAPTHLPELGEEKLTVEAAVRIRDDEDGSASKNGEECERENGFLEVETDLVESVSKSSGEDHLTEEVDDAASRALEDSRSRTSSGECGQNDVPLTEETDDATAKTTPTTSHDNESPAKVAYAIDVSGHLDSIFPSTSGSPSPERTTMSPVDDTFSTVSERKAWYRISRPGSMRRHNLGDEEGYTRVGWAKSRTRERTLKIVRRWMEEDSSGGGLNLLGRRLGSGRSTSFNWDSPASTTPVPIEELLRSRERGVERLGGPARAVAAFDWSGRVDVVAVASQPAEASMVGVPLKGPQALQPADQAFSLKAPHPSSTAVAPSRQTASSPSPAAAGDGNNEEEEEGEEEDEDDWGEMVSAPASTRKAAAWSGFGGDMEESPAREATSRLLLPGSPAAGSAASRPLMSGESPMSRGPTEDDDVVKRILGAIPDLSYMVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRL2</accession>
    <name>A0A367LRL2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRL2"/>
    <dbReference type="STRING" id="1330021.A0A367LRL2"/>
    <dbReference type="OrthoDB" id="4940504at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI17086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="458" mass="46855" checksum="C0B5316C94F9E45B" modified="2018-11-07" version="1">MKNEERGEADVTVQQAPVVDSVVAPVPQKKAKGDTFVRVTKSIGSVLMGITFLAMIAAVIFLVTRCENSTKASGSELIHAENVVSKAAHQLILRNDAAANPMAVVGPSGTGLVTFVTPTVTVGNLGEATTSSTTVTPVVGVSVPISTQTALSTIYSFWTSDVTDFVTMTTTSTTTVTRPVSKNPEEDAVCVATTATMTVSVYLTLSPVPDETVTGDASTVTDVSTDLYLTHSLPDVTLSGNPSTQTEVQTQVSLTTGLPDATVSGDGETKTAVQTDLSLTSGLPDATVTGSPSTVSNVISSTISQSVVSIFTTVVITDFWGTFNPSSQTSTTTATASSEATLTLTVTVSDLEQKDITSAPASASSSILADLTSESSSNYGGTKTVTMTWTGGAPLATSLYTTIRYPPVTNATTGGGAAWTSAAGEPVVVSDGATKPKPKGSGTLSCTVMLMAIIMLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LSB5</accession>
    <name>A0A367LSB5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1997</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LSB5"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI17333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="224" mass="22516" checksum="0A8CABB488F4CE0B" modified="2018-11-07" version="1">MPLALSEQGGSGSSSRSNSSRSSSRSNAWPRGEGGRASPPPAIRGEEGGKRAKLAQKAAAAAALIAATASTDNFARNKAELGKLATLEPNAAANNNDDYYTKAAAKVDNYADGAVNAGRVEAVAAAAIAIADAAAARKAKKAIFIAATRAKRREEACRAAKRAAAPALAQAALAALDKELAVAGNKGDNNNADNEEEEGAAGRSASNADKAPPQPGNAQPQGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LSL7</accession>
    <name>A0A367LSL7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">methylcrotonoyl-CoA carboxylase</fullName>
            <ecNumber evidence="3">6.4.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-methylcrotonyl-CoA carboxylase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_2895</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-methylbut-2-enoyl-CoA + hydrogencarbonate + ATP = 3-methyl-(2E)-glutaconyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13589"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57344"/>
            <dbReference type="ChEBI" id="CHEBI:57346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AccD/PCCB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.4" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LSL7"/>
    <dbReference type="STRING" id="1330021.A0A367LSL7"/>
    <dbReference type="OrthoDB" id="439921at2759"/>
    <dbReference type="UniPathway" id="UPA00363">
        <property type="reaction ID" value="UER00861"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905202">
        <property type="term" value="C:methylcrotonoyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004485">
        <property type="term" value="F:methylcrotonoyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000004">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000007">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045190">
        <property type="entry name" value="MCCB/AccD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855">
        <property type="entry name" value="ACETYL, PROPIONYL, PYRUVATE, AND GLUTACONYL CARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855:SF13">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="8">
        <location>
            <begin position="105"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="9">
        <location>
            <begin position="372"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="79"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI17411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="614" mass="65332" checksum="2301650D24331B37" modified="2018-11-07" version="1" fragment="single">TTPNLIITSSSSSSSSSSSSSSSSSSSSSLLLPVSIQTPPKMLLRPSPPRTTTPKSIPSLLPLLLLLPRRSASRLTPSHQATTATRLPSTIDPSSPEFRHNAQQMTQLMDRMQDLTRKAQLGGSDASRARHVGRNRMLPRDRVAALLDPGSSFLELSPLAAHELYPEAHVPAAGIITGVGQVEGVTCMVVANDSTVKGGSYYPITVKKHLRAQTVAQENHLPCIYLVDSGGANLPHQADVFPDQNHFGRIFYNQARMSAAGIPQISVVMGPCTAGGAYVPAMSDEAIIVRNQGHIFLAGPPLVKAATGEVVSPEDLGGGQMHSSVSGVTDYLAVDDAHALVLARRCVSNLNWPRNNSRSSTAAGDEQVDDDPPLYDQQDLLGIASPNLRKPIPTRDVIARIVDGSRFSEFKASFGTTLVTGFASIHHHPVGIVANEGILFAASAVKGAHFVQLCAQRGLPLVFLQNISGFMVGSAAERDGIAKHGAKLVTAVACADVPKFTVVVGGSYGAGNYGMCGRAYGPRFLWMWPNARIGVMGGEQLAAVMETVGKKVDPELRARIEAESDATYSSARLWDDGIIPPQHSRRYLALALDAAMGGRNKVVPNDTRYGVFRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0C2</accession>
    <name>A0A367L0C2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5872</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000023">
        <property type="protein sequence ID" value="RCI07878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0C2"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI07878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="67" mass="7243" checksum="4886CB59E1F24333" modified="2018-11-07" version="1">MQNVEAPAVVPSEYLKTSGSDIPSVWSLRRRRYLAQDGGGDNLGVTQKLVSSSFSSALHLCLCLEFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0D6</accession>
    <name>A0A367L0D6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PhoD-like phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000023">
        <property type="protein sequence ID" value="RCI07895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0D6"/>
    <dbReference type="STRING" id="1330021.A0A367L0D6"/>
    <dbReference type="OrthoDB" id="9999821at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043904">
        <property type="entry name" value="PhoD_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689:SF3">
        <property type="entry name" value="PHOD-LIKE PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19050">
        <property type="entry name" value="PhoD_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoD-like phosphatase" evidence="1">
        <location>
            <begin position="165"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase" evidence="1">
        <location>
            <begin position="375"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase" evidence="1">
        <location>
            <begin position="462"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI07895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="707" mass="78901" checksum="A9A427E522044D39" modified="2018-11-07" version="1">MTPHEAAAVVDGNPYASASRWRHQESTSFYRHAGSIHSSSSEGAAVVADGPEQADDGKEILCGPLLNYRRMDEDRWYGSVLVVVKGGGKDRIPHQPALILSRAGREDGDVILPRRLYSDHRVTFWAFDLAIPLESDEIKYEYRLPEMRFGNDYKPRVNGFFVPAVDESMRIMFHSCNGFSVGTDEAAFSGAPLWKDVLRKHAHAPFHVMVGGGDQIYNDGIRVDGPLRRWTDIGNPKKRAEFPFTEELRAECDDYYLENYLGWYDAEPFAIANGQIPQINIWDDHDIIDGFGSYVDHFMRCPVFRGIGGTAHKYYLLFQHHVSPPASTYTTDCDQDPDPAQLVDTFVAPPKPGDEYIIGKEPGPYVAEHSYNLYCRLGARVALVGIDARTERTRHQINYPETYDLIFQRLRDELRMSAASSRPIKHLIVLLGIPIAYPRLTWLENIFRSPIIGPIKFLNRRFGLGGGLFNHFDGSVDLLDDLDDHYTARTHKRERAELIFQLQALAAAFSVRVTILGGDVHLAALGRFYANPKLGLAVEEDNRYMANIISSAIVNKPPPQAVANLLARRNKIHHLDGETDETLLHLFERDPTGSNKTASFNHCTMPSRNFAVLTENSPNNEAQPNGVVSESFAGRDGHSPLHQGEVGAGSKHKAALMETHGRGSDGGLDVCINVEMDQHDPEGKTQGYGLTIPLLRFETPPTTASES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0J7</accession>
    <name>A0A367L0J7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RWD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_5866</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000023">
        <property type="protein sequence ID" value="RCI07927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0J7"/>
    <dbReference type="STRING" id="1330021.A0A367L0J7"/>
    <dbReference type="OrthoDB" id="277175at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040213">
        <property type="entry name" value="GIR2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032378">
        <property type="entry name" value="ZC3H15/TMA46_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12292">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16543">
        <property type="entry name" value="DFRP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RWD" evidence="2">
        <location>
            <begin position="8"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI07927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="237" mass="27128" checksum="CB2F8710B55C8454" modified="2018-11-07" version="1">MPREAQLEEREVLESIFPDEITHMSETDFRITVSLDAPDPSPPPPRLLLHVRYPEDYPDVAPQLDLLAHPDDDSHHPYLSVANDRQQLLAGLEPIIQESIGIAMVFTLVSSLREAAEALVQKRIDDEADIRQEALLAAEREENNKFHGTPVTPDTFHQWRRAFRTEMEEQHRRDEEDRLAELKRAKIKEPVKLLTGRQLWERGLAGKGDDDEDDNDNGDSHSAVPTKRLEKLQVEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0M2</accession>
    <name>A0A367L0M2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_7856</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G. eIF4E is also known to interact with other partners.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000022">
        <property type="protein sequence ID" value="RCI07961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0M2"/>
    <dbReference type="STRING" id="1330021.A0A367L0M2"/>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.760.10:FF:000004">
        <property type="entry name" value="Eukaryotic translation initiation factor 4E-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019770">
        <property type="entry name" value="TIF_eIF_4E_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF8">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00813">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0810">Translation regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="231"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00062860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI07961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="256" mass="28706" checksum="886D27B6F89AAE28" modified="2018-11-07" version="1">MATIATPISNSDQQVDLSTIPISPGGKEDSAEERTGDKPVTVFHDKDNFNVKHPLQNKWTLWFTKPPTGKGDNWNDLLKEVITFNSVEEFWGVYNNVAPVSELPQKADYHLFKAGVRPEWEDPQNKHGGKWSYQYKEKRTIDIDRLWLQVMMGAIGETLENEDDGEVMGVVVNVRKAFYRIGIWTRTLGQRVVGRGDGDVSGGKGRPLEKGKDILMSIGRRFKGVLELPSSEQVEFSGHTESAQTGSSRAKPKYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L110</accession>
    <name>A0A367L110_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAM192A/Fyv6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_5783</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000023">
        <property type="protein sequence ID" value="RCI07902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L110"/>
    <dbReference type="STRING" id="1330021.A0A367L110"/>
    <dbReference type="OrthoDB" id="75807at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039845">
        <property type="entry name" value="FAM192A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019331">
        <property type="entry name" value="FAM192A/Fyv6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13495">
        <property type="entry name" value="NEFA-INTERACTING NUCLEAR PROTEIN NIP30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13495:SF0">
        <property type="entry name" value="PSME3-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10187">
        <property type="entry name" value="FAM192A_Fyv6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM192A/Fyv6 N-terminal" evidence="4">
        <location>
            <begin position="37"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="16"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="103"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="212"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI07902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="311" mass="34221" checksum="9E5A4C755F54DB48" modified="2018-11-07" version="1">MASGFVSGGTIGEKAAAAAAAADEADQQRPPLTAAGSHKAEWEVVQQELAAERKRREEARLKAASGEEKTLYDILQANKAAKQAAFEEKFRLKNQFRALDDDEAEFLDEIREREREEEERVRRETEERVRAFRRARQNSGGGDEDVDDEETKDDDGEGKKKAEAEGEGELDGAEWTVAPVGRKRKRGLKGGRSLVRPKTVVVDAEPVVEPLKGRLEKGKGGREEKRKKKVSTLRQRPLKLPLIQPSTCSSGTTMEAARRSSSGLMWKRLMRSAKRASTTIGEAQMSSLVVAYGGDLASDVVCQLAPVEEAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L199</accession>
    <name>A0A367L199_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6365</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L199"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="66" mass="7799" checksum="75CF70A795606439" modified="2018-11-07" version="1" fragment="single">MENKKNNKKKEKQKRGGKKRGPLRLRRRKKKKETILPTSRITRLDPNNTRVTASFASIILRSPFRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1K4</accession>
    <name>A0A367L1K4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8346</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000020">
        <property type="protein sequence ID" value="RCI08301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1K4"/>
    <dbReference type="STRING" id="1330021.A0A367L1K4"/>
    <dbReference type="OrthoDB" id="3180714at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF4">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="47"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="214" mass="24494" checksum="A2FD9720CC9165CA" modified="2018-11-07" version="1" fragment="single">MSPRCLTDSGYVPIDDIYSGEEDTNTLKHWEPVQKHNTEPQFQNRFFKIQRSETAGWGAFAVCNLRRDDLILMEKSLFVADQSSLFRAFETLDSDSKNIALSLHVNELVKPGTPPIQAIWATNCFTRAGLFPIAARFNHACYPAHNVRFYFDHESDCLVLRVRAERVAAGEELRISYGRDRTVAELYMTYGFRCRCGACPGLSDRDVQRLTSQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1N9</accession>
    <name>A0A367L1N9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF4536 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8801</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1N9"/>
    <dbReference type="STRING" id="1330021.A0A367L1N9"/>
    <dbReference type="OrthoDB" id="6604875at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053092">
        <property type="entry name" value="Mitochondrial_unc_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28048">
        <property type="entry name" value="ACR195WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28048:SF1">
        <property type="entry name" value="ACR195WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="103" mass="11587" checksum="84C780FB6E197B8D" modified="2018-11-07" version="1">MAGDKMPSLYALEKPQDVQQLVRQDRDDDCLSCRIVGKRHRLSSIPALLGLAAYGYLSGMSQLNRRRASIMQSKSVFGFRSRQMGVVGISIALTWMGLWRALR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1T8</accession>
    <name>A0A367L1T8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AVL9/DENND6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_8893</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1T8"/>
    <dbReference type="OrthoDB" id="26278at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018307">
        <property type="entry name" value="ABL9/DENND6_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051731">
        <property type="entry name" value="DENND11/AVL9_GEFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017:SF1">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31017">
        <property type="entry name" value="LATE SECRETORY PATHWAY PROTEIN AVL9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09794">
        <property type="entry name" value="Avl9"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AVL9/DENND6" evidence="2">
        <location>
            <begin position="26"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="AVL9/DENND6" evidence="2">
        <location>
            <begin position="235"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="601"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="699"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="623"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="647"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="705"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="769"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="781"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="813"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="827"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="860"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="877"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="899"/>
            <end position="938"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI08376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="938" mass="103142" checksum="69030C8FB2F3E823" modified="2018-11-07" version="1">MSGSDDNSSLDGARSLSISPSPFAPLVTVVGFHHARGPEVETWFGVDQGADPCIDFAWSLLPFMALSDGAHASEEDFSYFTLLRPATDSEPATSLFGISCTRQLDASQLLNRPADVTRSTVQKAVVVIADTPQFFGMLRERLSVVTQAWFAQRDFSDMEILRRFQESLADEKARGALEAEPNRDQYLGMSLRELIHEFKWQTLVLFKCCLLQPKVRPVPEPSQRPSWQADPTTGQMLFFGSRCDRLCMVQFSLISLIPGLLHSLQDCADPDLDNYNKTLSRPSSLQSSNRSSLLSFMGLPLQIFGKGGFFGPYTPLQQLDILADFGTKSYLVGSTNSLLLQQRDRYSDILINLDEDTVSITSPSLRSALALTAADRRWIDFLTLEVNDTWDEANPSRPKTMQYIGSEEFIRSQFEAYILGLISSVKYHNFLASNPDGSKGAEDPAVDYGLDWIEAWERTENYRIWNSHTDANLFAVSEPKHPCAGGLTIDDVQRRISEQVKELHLDERFAQGREMLGRNLAVGREKASTMLNRLYADVEYLRESQRRRSDDAKSQDSKSPTEKSQAQYSVDLAKAQQTMQSVGVKASAYMSSWATWAGEKRKGGGWGAAWGRKSKTAAAPGSPDNQAMSPPSSRTPSMDDHAKRPPTQASFSESILSAASGSQDERPLSKSSDAELVPHPIVGDILVTRMEANPEIHEEEQLVKAVPTTEQETAAAAAAAKAPAATDVQDKHMPEEGSSVRSEEEESAPDEMGALKEESNAWREQQAAADDDDDDDDDDDVIKSDNKSEQEPTTIANDMKSLEEESNPWREQQPAEEKNETPETHHPPTQSPSITQDNKTADAEMPSPQATNDDDDDDTPSPKEDANSKPHKDEETTTTPTTITETPAVQEVTKEADDASSSSPIPAEKVPVSSEKVVVADQASSPAAEAAALSPSLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1U4</accession>
    <name>A0A367L1U4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_6283</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1U4"/>
    <dbReference type="STRING" id="1330021.A0A367L1U4"/>
    <dbReference type="OrthoDB" id="272141at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14137">
        <property type="entry name" value="STKc_GSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000055">
        <property type="entry name" value="Glycogen synthase kinase-3 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000009">
        <property type="entry name" value="Glycogen synthase kinase-3 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050591">
        <property type="entry name" value="GSK-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039192">
        <property type="entry name" value="STKc_GSK3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057">
        <property type="entry name" value="GLYCOGEN SYNTHASE KINASE-3 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057:SF0">
        <property type="entry name" value="PROTEIN KINASE SHAGGY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="35"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI08192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="394" mass="45226" checksum="0737B5D4267E4FEA" modified="2018-11-07" version="1">MSSHRPNAFNSLRMGEVIREKVQDGITGETRDLQYTQCKIVGNGSFGVVFQTKLSPSGEDAAIKRVLQDKRFKNRELQIMRIVRHPNIVQLKAFYYSNGDRKDEVYLNLVQEFVPETVYRASRFFNKMKTTMPILEVKLYIYQLFRALAYIHSQGICHRDIKPQNLLLDPNSGILKLCDFGSAKILVENEPNVSYICSRYYRAPELIFGATNYTTKIDVWSTGCVMAELMLGQPLFPGESGIDQLVEIIKVLGTPTREQIRTMNPNYMEHKFPQIKPHPFSKVFRRADANAIDLIARLLEYTPTERQSAIDAMVHPFFDELRDPATRLPDSRHGSGQIRDLPDLFDFSRHELSIAPNLNQKLVPPHARPELASRGLNIDDFMPMTKQEMMAKLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1V3</accession>
    <name>A0A367L1V3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Heat-labile enterotoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_8860</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1V3"/>
    <dbReference type="STRING" id="1330021.A0A367L1V3"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090729">
        <property type="term" value="F:toxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.210.10">
        <property type="entry name" value="Heat-Labile Enterotoxin, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001144">
        <property type="entry name" value="Enterotoxin_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008253">
        <property type="entry name" value="Marvel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39608">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G08640)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39608:SF2">
        <property type="entry name" value="MARVEL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01375">
        <property type="entry name" value="Enterotoxin_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01284">
        <property type="entry name" value="MARVEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00771">
        <property type="entry name" value="ENTEROTOXINA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0800">Toxin</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016768395" evidence="11">
        <location>
            <begin position="19"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="744"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="779"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="813"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="851"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="domain" description="MARVEL" evidence="12">
        <location>
            <begin position="752"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="624"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI08395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="899" mass="101871" checksum="36D3363FA310E9C9" modified="2018-11-07" version="1">MRCQHLLHLSLLTTFGSAYKPPRTVYRADRIHPMDLELQGGFIPRGMDGSGHNRLSLDFSLYNHVLGTGTGSSKSNSAFVATSKTERAARRMLSLTSNGVGFIYTIHVTSNFYDVEGTLGFYYMHTTEQEVAALGRVQFSQVVGWTEFRQGVEQPFVKNQKYDHKLFDTEEWAGTEYRIAGFPDNHVAWKQEPWKSARESGPSLDLPCSSPPTSRKRQMMKCDFLLQPQPKPEARALLGWEWEVDAEAEKLFAEFASKFGLMTRAAVSWHMTLPELRERFRRSSHRVSSLKSHRVRWWSRGMAAVNAAVSGQSIFEVAASGTKMMSVLDRASIIMSILPGIGCSFQAWADEAHGKVDPSDIMLCVAADLLMVNGLGLPLIALMSLRSIRTKYLDSKMPTPAEMRQLRDKGWESYQESMMNFLKSPDFIAMSRNHFMAEMAGVMFEAAEALSRLRLMKREALSKPRRSFEEKRETRAAFDQSESALRSNLSAQAWERHDRLKSELPLIIKTSLRRQASEFNEIFIGKFEDDVEDNRYEPWANWGLTTVDLEMHAQAMVWHLRRSLPATPELGEIQHRVHEALTYLETPSLCTEYRPNGAIVFHCGDPSDGDNYGRGRVRSGDEAVYRPPKYQSGCNDTRERKGHHHLSSLHSVEQSPPPCTERRGDGGVNFNCGGPSDGESYRANDATMRPLVDGRHACGKIRGPPPPNVIRWIDIEPPPSVEHNWLQLYFTASLKKTTMGMLRFLVMGNHFAIFISSLIVTGILSYFIHRSSYRDTHIIFQEVIAVITFVLWLFGMLLPLVDRYKGHLMPVNLVLSYLWLTAFIFAAQDWSGDRCYDGPPMLENCGKKHTAEAFMFLTFFFLICNTVSEAMLWRSIPRDADFSKTGTARGVDNSATARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1X1</accession>
    <name>A0A367L1X1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_8971</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1X1"/>
    <dbReference type="STRING" id="1330021.A0A367L1X1"/>
    <dbReference type="OrthoDB" id="5394411at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024624">
        <property type="entry name" value="Pyridox_Oxase_Alr4036_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28243">
        <property type="entry name" value="AGL049CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28243:SF1">
        <property type="entry name" value="PYRIDOXAMINE 5'-PHOSPHATE OXIDASE ALR4036 FAMILY FMN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12766">
        <property type="entry name" value="Pyridox_oxase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding" evidence="2">
        <location>
            <begin position="14"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI08421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="261" mass="28841" checksum="DEA4DE18233EB6B7" modified="2018-11-07" version="1">MATPSKASSALIEAPWRAAFLSHVQQLEPPTFVLCTLGAQHSGVRGRTVIFRGMWADLPVHPQNTARLNPDIYQTHLPTITTDARMEKASELMAKDPANAQSGGGGPVEAVFWMPEVQTQWRLRGRGYLIGPDIDTDAGASVRAALTPHMRRIAECSSDYSWSWSREVTAHFGNVGPLMRGSFRNPPPGTPLDDDDQSPAEPLGLGQKVDDLDDDVARSNFRVVVIVPDEVDKLDLSDPQRGRRWNYKDCGGSWKETELWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2F2</accession>
    <name>A0A367L2F2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Swim zinc finger domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_4695</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2F2"/>
    <dbReference type="STRING" id="1330021.A0A367L2F2"/>
    <dbReference type="OrthoDB" id="5291055at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022025">
        <property type="entry name" value="Amidoligase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847:SF1">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12224">
        <property type="entry name" value="Amidoligase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI08588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="36386" checksum="6A1B274B0D8C8AD0" modified="2018-11-07" version="1">MVRHYNFGIEIEAVGRPYGGGQTFSNVDWYRQLAQKLENRGVSAAYDNCSQYSKHPEYYGGKWFVTRDGSLKRPRPLVCMEVVSPRLDTKQKTSRILSDFWEAMRVHFSPQRDLSCGGHVHVTPVSARNRFSLASLKSIAFATVAYDQFVAHVLAPARRDNRYCVPNGQSPGSGLCAALGGDGPRTMAVLTRVAAGIRACVDETALYMYMQGNRYVLWNFQNIFPHPRTGRCSGTVEFRGGNQFLNTRGTLAWVAFVLGFITLAIKENLLHNLTTVIVVSPHEPNFPHRLAEWWTRIRRAAKKSKMQRHLPDEYWQMRTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2R3</accession>
    <name>A0A367L2R3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Mpv17/PMP22 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_4764</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the peroxisomal membrane protein PXMP2/4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2R3"/>
    <dbReference type="STRING" id="1330021.A0A367L2R3"/>
    <dbReference type="OrthoDB" id="10267969at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007248">
        <property type="entry name" value="Mpv17_PMP22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266:SF80">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11266">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04117">
        <property type="entry name" value="Mpv17_PMP22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016819041" description="Mpv17/PMP22 family protein" evidence="7">
        <location>
            <begin position="25"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI08721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="198" mass="21570" checksum="C32193503AEC3146" modified="2018-11-07" version="1">MTPRPLVTATVQAALLGALSNVLAQLLTADESTESIDWIPVLQFLLFNIVSTPPNFLWQEFLESTYPRKNNGSLSIYNTMVKFALDQTIGALVNTLLFSIFIHALQDAMAHAPHMESLPAAAAYFMKPGAVNLTRVDALAILDAAKRDFWPVVVTGLKFWPAVSLINFSFVKTVATRNLVGASAGVVWGIYMSTVAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3N0</accession>
    <name>A0A367L3N0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial</fullName>
            <ecNumber evidence="3">2.3.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_4936</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.12" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI09035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3N0"/>
    <dbReference type="STRING" id="1330021.A0A367L3N0"/>
    <dbReference type="OrthoDB" id="537444at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000010">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000003">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006257">
        <property type="entry name" value="LAT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01349">
        <property type="entry name" value="PDHac_trf_mito"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF90">
        <property type="entry name" value="DIHYDROLIPOYLLYSINE-RESIDUE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="9">
        <location>
            <begin position="165"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="108"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="115"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI09035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="445" mass="46569" checksum="7AD0C79E5001E3E8" modified="2018-11-07" version="1">MLSAALGRRALAPTRRALLVRMPALSPTMQAGNIGAWQKKPGDAIAPGDVLVEIETDKAQMDFEFQERILKESGEKDVPVGSPIAVLIEEGTDVSAFEKFTIQDAGGDAKSEAASGSSSSSSSSSSSSPSSSSSDSSSTSSSSAPPEQYASSGSRLQPALDREPKAEVAAKRLAREKGVNLDGVKGTGKGGNITVDDVNKLVSSSGHAGTGAPAAAAYEDQPISSMRKTIAKRLQESVHDNPHFYVSSTISVTKLLKLRQALNSSGEGKYKLSVNDFLIKAMAAACRKVPAVNSSWRDGNIRQFKTVDVSVAVSTPSGLITPIVTGADGRGLESISAAVKELAKKARDGKLKPEEYQGGTISISNMGMNEAVSNFTAVINPPQAAILSVGTTRKVAVPGSEGGVEWDDQMTVTGSFDHKVVDGAVGAEWIRELKRIIENPLNLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3X8</accession>
    <name>A0A367L3X8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycine zipper 2TM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5021</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI09124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3X8"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053019">
        <property type="entry name" value="GATA_zinc_finger"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23353:SF23">
        <property type="entry name" value="PROTEIN HAIRLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23353">
        <property type="entry name" value="RAB-GAP/TBC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="127"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="22329" checksum="2E503021F17C609A" modified="2018-11-07" version="1">MSNQGYYGGGGGNDNNNGGFNSGSQQGNYSHDSKGNNGGGDGDRGLGTAILGGGAAGFAAHHAGHTGALGTIGAAAAGAIGANMLKHHHDKGKHDKDEDEGKHGKHGKHHGSDDKYNDNSSGGYGGNNNNNNNNNSGGYGGNSSSYGGNNNNNYGDNKHGGYGDDKHGHNQQGSGGGHHGLLGGLMGHHGSGHNNSNQGYGGNNNSGYGGNNNNNNNNNHGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3Y5</accession>
    <name>A0A367L3Y5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Replication protein A subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_1566</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">As part of the replication protein A (RPA/RP-A), a single-stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the heterotrimeric canonical replication protein A complex (RPA).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the replication factor A protein 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3Y5"/>
    <dbReference type="STRING" id="1330021.A0A367L3Y5"/>
    <dbReference type="OrthoDB" id="1751331at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04474">
        <property type="entry name" value="RPA1_DBD_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04475">
        <property type="entry name" value="RPA1_DBD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04476">
        <property type="entry name" value="RPA1_DBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04477">
        <property type="entry name" value="RPA1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000041">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000064">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000090">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000117">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047192">
        <property type="entry name" value="Euk_RPA1_DBD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013955">
        <property type="entry name" value="Rep_factor-A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007199">
        <property type="entry name" value="Rep_factor-A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031657">
        <property type="entry name" value="REPA_OB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004591">
        <property type="entry name" value="Rfa1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00617">
        <property type="entry name" value="rpa1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165:SF4">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04057">
        <property type="entry name" value="Rep-A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08646">
        <property type="entry name" value="Rep_fac-A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16900">
        <property type="entry name" value="REPA_OB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Replication factor-A protein 1 N-terminal" evidence="11">
        <location>
            <begin position="9"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="OB" evidence="10">
        <location>
            <begin position="187"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Replication protein A OB" evidence="13">
        <location>
            <begin position="296"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Replication factor A C-terminal" evidence="12">
        <location>
            <begin position="450"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI09145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="606" mass="66507" checksum="45012A7356A5AFA9" modified="2018-11-07" version="1">MAANASALLSRGALDAIFNDADKAARQFPVPVMQCLQIKKMAPSAQGGDRYRLVMSDGVHYVQTMLATQANHVVQDGKLDRGSLARVKQCTPNNLKGKNILIILDIEVIESAGVHDKIGEPVAVETRPAPDAAIIAGSEFYGAKKEDAASKAAAPAKSIPSRPAGATHAGAANIYPIEGLSPFAHKWTIKARVTVKSDIKTWHKPTGEGKLFSVNLLDESGEIRATGFNDQCDAFYDLLQEGSVYYVSSPCRVSLAKKQFSNLPNDYELTFERDTVIEKATDQADVPQVRFNFCTIQELQAVDKDSTVDVIGVLKDVGDVGEITSKKDGRPFQKRELTLVDDTGYSVRVTVWGKTASSFDVRPESVVAFKGTKVSDFGGKSLSLLSSGTMTVDPDIADAHRLKGWYDSAGRTDKFATHQSNLGGATGRKDEAKTIAQVKDENLGVDDQAYYSIKATIVFVKQDNFCYPACSSQGCNKKVTPLGDGTWQCEKCNVSHEKPNYRYIMSINVADHTSHQWLSCFDETGCLIMGRSANELMEMKENDEAAFMAAFDAVNCKKLAFRCRAKMDNYGDTQRIRYQVMSASMLDYKVEAERLVELIKQYDMKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3Z9</accession>
    <name>A0A367L3Z9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1561</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3Z9"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="132" mass="14226" checksum="63809CBA67F1A807" modified="2018-11-07" version="1" fragment="single">MRLPRGAFPADGVDGGCGEEQASSAHHCGTSPSLLTSVTKPRGVDRGGAKEDEELDVSRRLGGYRGTCWPDARGELVLLAAGGVRRRASPRGQRAYLGLDAAWVQTQRLVTPPSAPLDDCTQYRYLAGWYRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4P6</accession>
    <name>A0A367L4P6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000015">
        <property type="protein sequence ID" value="RCI09406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4P6"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="176" mass="20439" checksum="3772773CA1B1A367" modified="2018-11-07" version="1">MLVRRDVEEKKEKKKRRSVVSTASTDRRKERKERRRREGESTMMRDDDGRQRRSSSVLHSDTTTERSYNQRVSKKKKKKKKNLTKEREGQQAKDDFVLLVRDRERERELIGGLRVGFLCDLQRRLRRGEQGASSVYAVKMQSGSPHPSDNSPRVSNEMVMKGGATCLWGVSSEKSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4Q2</accession>
    <name>A0A367L4Q2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L249_3725</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="12">Forms a heterodimer with SLX4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3A3 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the SLX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000015">
        <property type="protein sequence ID" value="RCI09391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4Q2"/>
    <dbReference type="STRING" id="1330021.A0A367L4Q2"/>
    <dbReference type="OrthoDB" id="2160351at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033557">
        <property type="term" value="C:Slx1-Slx4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10455">
        <property type="entry name" value="GIY-YIG_SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03100">
        <property type="entry name" value="Endonuc_su_Slx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051421">
        <property type="entry name" value="RNA_Proc_DNA_Dmg_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031774">
        <property type="entry name" value="SF3A3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024598">
        <property type="entry name" value="SF3a60/Prp9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021966">
        <property type="entry name" value="SF3a60_bindingd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027520">
        <property type="entry name" value="Slx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048749">
        <property type="entry name" value="SLX1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786:SF2">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786">
        <property type="entry name" value="SPLICING FACTOR SF3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16837">
        <property type="entry name" value="SF3A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12108">
        <property type="entry name" value="SF3a60_bindingd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11931">
        <property type="entry name" value="SF3a60_Prp9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21202">
        <property type="entry name" value="SLX1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82771">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 12" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 12" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="15">
        <location>
            <begin position="408"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="GIY-YIG" evidence="14">
        <location>
            <begin position="493"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="320"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="515"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="791"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="106"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="796"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="819"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="873"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCI09391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="911" mass="105267" checksum="062E430E35DB401E" modified="2018-11-07" version="1">MLTILEDERYIHEDLERLEQGIADRVRDDPNHIRNRLNRDHEVAQLLKQMQLQLQHLISSHDDPARSAAKELQKLDTADPFGQFYEHFEELREHHSRYPNEQAENSEQRYKPKHHGDSDGLMHCIVDTIFSGEEAYGRFFDLNTCHEAFLNLPNAKRLTYLQYLENFDNFTPGHGGIRRAEKLSDQYLQYVSQLVDYLTSFRKRTRPLDDTEKVLREFDQEFDKAWEADSVQGWTLDKPADASITTDEAAVWCDDCEKEFKNRNVYNGHLNGRKHIKAAELRKQRKADDGEQVPTRKGGAVSTTRIKERVIAEREHRVKRLASSMSTERSDTRVNTERKQGMTERERQQELENLLNVSEAPRSSAEEGGERGEDGEEKIYNPLKLPLAWDGKPIPFWLYRLHGLGVEFHCEICGNFVYMGRRAFDKHFGEPRHIYGLKCLGITNVTLFRDITKIEEALKLWDRLQQEQKKSKIDEGSIVQMEDGEGVYRPLPALYTVYVLRSSVRKASLYIGSTPNPQRRLKQHNGDSKGGARRTSSLRPWEMVALVSGFPSMISALKFEWALNNPHLSLHIPDESRLTVVKRKRWTRRRKLKRPSHTLLSVVSNLHLLIGVPSFVRWPLDLRFFAPDVHAAWEGWMAAPKSRDGSATKCPSPCRRGLRILTDFAQDAAPDQRTGAQALPLNYRPMRDYVQKAHDVVASNRQISCVHCGEMLKEGRGMHAMCPLDGCTAMGHLDCWSRHGLADDAEGNLIPDMFCCVSCGGEIRWSDMVRELSLRIRGQKEVERLLREAARKRKKEEKEKEKAERQSTKRTRRKKAEAAETEEEEEEGEVEVKVDEKGKRKRKKKVAVVETEDEEEDGESKAMRQPTKRTRKKEAAPLKTEVEEVEDSVFRSLPKKRQRKRKAEDTEVVSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L525</accession>
    <name>A0A367L525_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_4066</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L525"/>
    <dbReference type="STRING" id="1330021.A0A367L525"/>
    <dbReference type="OrthoDB" id="72053at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052250">
        <property type="entry name" value="PDI_TMX3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426:SF1">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016687694" description="Thioredoxin domain-containing protein" evidence="7">
        <location>
            <begin position="19"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="620"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="8"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="195"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="158"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI09530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="673" mass="76260" checksum="748438718EB2AA5F" modified="2018-11-07" version="1">MRLLALALILGAAAPGWADDTDAQPEATIFNSITVPPLVELTPANWKDEVAKSRWLAVKHYSPYCHHCQRFAPTYQTLYEFYYTSKTDDGAPVAESYDLRFGIINCIRYSDFCEEHGVQRYPTTVVFDGGEKFDSIEGNQKMPAVSKIIEAALDKTKPGTRPKKLALPDPGAKESPPPAETPPANKAVEGKESEEKPAQTTVEKPLSTANPDGVSIPLTAESFQKMVTMTQDPWFIKLYAPWCHHCQALAPTWQQLAKSMRGKLHIGEVNCEKESVLCKKDLNVRAYPTIIFFKGGERIEYNGLRGLGDFVQYAEEAMELAGGVPDVDAQELKKVEEKHDVVFIYFYDHATTSEDFKALERLPLSLIGHAKLVKTKDPKLYDRFKITTWPRLLVSREGRPTYYPPLTPDEMRDARGVLGWMKSVWLPLVPELSPSNARQIMDGKLVVLGVLNHDDHDAFQASLREMKSAANEWMDRQLQEFQLERKKLRDSKQMRIEEAEDRNDERALRAAKAIRVNMDSSGRKEVMFAWVDGVYWQRWIRTTYGIDVKDGERIIINDEDNRRYWDQTVTGNHMLVSRTSIMETLDKIVYGPSVIKPKMTISAPEKMLLDIRVTLMEHPLLTLGCVVGIGFGVISFIRGRNRRRGGHFRLDDTMGIRELKDGLLGGNGNHKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5B1</accession>
    <name>A0A367L5B1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_4001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5B1"/>
    <dbReference type="STRING" id="1330021.A0A367L5B1"/>
    <dbReference type="OrthoDB" id="431825at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039754">
        <property type="entry name" value="Esf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012580">
        <property type="entry name" value="NUC153"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056750">
        <property type="entry name" value="RRM_ESF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12202">
        <property type="entry name" value="ESF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12202:SF0">
        <property type="entry name" value="ESF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08159">
        <property type="entry name" value="NUC153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25121">
        <property type="entry name" value="RRM_ESF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ESF1 RRM" evidence="7">
        <location>
            <begin position="172"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="NUC153" evidence="6">
        <location>
            <begin position="608"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="80"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="217"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="392"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="640"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="134"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="396"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="410"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="429"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="464"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="491"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="533"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="559"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="576"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="588"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="653"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI09609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="670" mass="75847" checksum="4786DDA0729D8C4C" modified="2018-11-07" version="1">MKLPKNDGHPSTGRIADARFASFETDARYRLPSKKHAKTTIDKRFSAMLVEEDFISNAKVDRYGRRIKSDSKKKALERLYRIESEGEDDETGDQGDMDEDEVVQRELRAAHALDLRKKRDPARDGGFSCSESDSSSDDDSGDEGEEAGGVDSHDGMQRFQDEQTEVESGQVTKRIAIVNLDWDHIKSTDLMALFSSFVPPDSGRIVNISIYPSEFGKERMQQEETEGPPKALFKDEPKPGASSDDDDDSDSDEAIKKELIEEGDDQDFNSDALRSYQLDRLRYYYAVMVCSDAETAHAIYEATDGTEYQASSNLIDLRFVPDDVAFDEEARDQCSEVPDSYTPVEFVTNALQSSKVKLTWDLHPEEASRKKSIQKAFSQSRAELEENDLRTYLASDSEDEVQDEGGDEAITTRRDRNTMREALGMTDDATAKRSKDGPVGEMQITFAPALGGGKAEGTAQEETTIEKYRRKERERKEKKRQGSSKVKAEAEGEEKDDDEDLGFDDPFFMTDEPLAVAGSKSAMRKEERRKRREEREAAEAEAAEQKAKLSGIMTEEADGLEHFDMKEIVRAEKDKGKGRKKKKKTREKTREKTREGLMQEGFEMDLGDDRFQAVFDSHEFAIDPSNAKFKATSGMKKLLEEVREKKRKKKRKAGGDGTKEEREAKREKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5F3</accession>
    <name>A0A367L5F3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5F3"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="398" mass="43795" checksum="89465C2B4C0E19BD" modified="2018-11-07" version="1">MGPPRESKQGRSEAGEYEDPGPPSHLRHSIREASPIQGLVEVSGVGRCMRGEEMRDRTDNSREQHDNDTTALSTLLGQDDREFFSLGEMKMKKMIMKSTLHRQLREGRYLVGENVWKRWWKRARHETDSLTQGQQPVSAKSHLDVLHLSPQVTEYSLEAVHVLQQAASDCDFYSGSALARTVAPKSPDGDERHCPIRSLQVPRQVAGTPLSHTLPTSSRLHCARERGFFSPLLSRSDVFVPQRTATDFIGSPVSPAKHLTVVHDVPDAFPVFFLDSPPRLSSPSYLVQDLKSCLTAPAMASPCALVLQSADTESWGERDSLFDQIESRAALTLAPTLLASTVLPDLIVNPLASPFCGAKHSSGSPFTPPLPFIPVDPKSYRQASAALSLHRGNTMTCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5L8</accession>
    <name>A0A367L5L8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3956</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5L8"/>
    <dbReference type="STRING" id="1330021.A0A367L5L8"/>
    <dbReference type="OrthoDB" id="2688021at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="268"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="442"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="527" mass="59348" checksum="BE346EFFB4A0F97F" modified="2018-11-07" version="1">MKQCLPVLRRRYLGKIRTLRIIWDVSYSSSSRHQMTKMHQNPNFDTASRTRIYCFLSLLIGVTLALLCLSSGLYIIATEPKTLGLPLDISPLTQELVILIVNVTLTLCIDGMMFTHSVSLRWALHHENGLQFNTNIRLLTSSSRSGPNRWYSNAATLFFLVLSYGSSSTLLPQTLTTPLLNATSLIGLGMALAGQAVIAAWCLLSNRRLIPTWSSNPLNATLAAIKMGTITRRPGRSLLSVHHQKHKLLPEPVCPAKRQRPMIIAHRAVPYIVIIVWSLAFLATAWVISIVLVSRTISPTCWNFTMMWNIGGYCFYNSAEFRFGSSDTYGPLYTYGQYTILCLLFVCAIQGLQTIGLHCVELLVNMSRDEAVWRRAYSETEKQAPGLQLTQSPLVAAVTSWENVILLFAKAVSHWALSQAMLPVFFPWDMKTVSIVFVYSRLALYALLAILLALFTTYLALRRPSGCQPTTLGHLQTIADLVDDWETDDHGRMWWGEKTWSSEQIRHAGTSCHRRLLSRIDVEAKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5Q6</accession>
    <name>A0A367L5Q6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5Q6"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="632" mass="72199" checksum="B7BAA63568C7653D" modified="2018-11-07" version="1">MGSTSSPPSCPTLLLIHDSAFLSNVLCPCLPMDYLCEGNHHHPPLRLHPTLDMCLTRLILLLSEEKETCSRQREKGNESFTLFLSPFLDISSRFFFPPFHDLMFSFDAIFIPFFLCSTTIIHCHDQPSTTLYSTSQMGSILPTASFSSTWIKHKSHLKLRISERDQLFPGQTTLCMRDIRVTPDWAPVHFVPPSMSNHSIAVVKAAELYGEEFWQGRRRQSQLEHTSTPRDTEIAADNAVLRHPIKEQQKRDRDDGVIREEIRARTSTSPWSNFFTGIGDLRKERGESKAPVEWTAHETYSYEKAAFRLVKDKAFNITSVDSSTFGPDLMVPNRMKTLNSIDLGRDDGSGGRVSSRHTASEEISLPIQWDWQDTAWDEMTEMEDGFPPVIRHRKRFLFQYSGTGKTRLGTPTRIQLSIFFSPYFSRSYTSLEAILYLSPGIVEYSERPRIGSKSTVFFDRRMRAMTMSLINSERQTTHHPKFHAVTLRNQPLNNYIVDRDSSVVPIGTGHTLIAGPRTMVFIFRFDMNDAVSTPLDSAFQHSVLCGQHQLYITASEALLYLRLGTTEVRRQTRKPSPLLSGRRVRTRESSQQSILKEVDSGSLLRQMANLFLKDLQPETFYRYMVSSPLKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L600</accession>
    <name>A0A367L600_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SPT2 chromatin protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_3839</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L600"/>
    <dbReference type="STRING" id="1330021.A0A367L600"/>
    <dbReference type="OrthoDB" id="5430658at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013256">
        <property type="entry name" value="Chromatin_SPT2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08243">
        <property type="entry name" value="SPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00784">
        <property type="entry name" value="SPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="311"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="34"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="162"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI09853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="38274" checksum="72999FEC857D2DA2" modified="2018-11-07" version="1">MPIGDLLAQISGENSPSASTFPRSTTSSSLPAKRKPENDLRHDIAKSPRPNPSRPAVARDKWPPPPRLSQQSPRSAAVPKPSAPPKTLKPAVPARPGPSPTTPSSATAKQSLKRGSFAEILARGQRAQAVMGQVGKIQHKKVEKGPAKTKDEAKPQPPKGKAAAAAAASSASASYKGTSKPVANNHPTANGSRSKPAPAGKRQEPAVNNSNGMKKPSQPVTGYTGTARPKQGLPSKKRDAPRGGALLNPPSVRHGSSKRSRYDDDDDDDDAEDLDDFIEYDDDEDEAAQPGPRYNYAASDASSDMEAGLDELDVEERRAELLARREDIQEERLERSLKAAKEDRKRRAMDAFRAGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L633</accession>
    <name>A0A367L633_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein S21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_3876</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bS21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L633"/>
    <dbReference type="STRING" id="1330021.A0A367L633"/>
    <dbReference type="OrthoDB" id="2501249at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070124">
        <property type="term" value="P:mitochondrial translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052837">
        <property type="entry name" value="Mitoribosomal_bS21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001911">
        <property type="entry name" value="Ribosomal_bS21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41237">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN MRP21, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41237:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN BS21M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01165">
        <property type="entry name" value="Ribosomal_S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="15"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI09881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="26578" checksum="9C70FB787D4CCC75" modified="2018-11-07" version="1" fragment="single">QLIPRCSLALLSKASTSLLRPPTTSRALSISRSSPRSEARSDDQQAAKPSPSTYNPNQQFWSNSEPSSKPPVAADPLSTWRRKNLPPPPPPPSPATDASSDRQESSSFATTPHHAYDTNHINVHHAVEEIYRESVSVVVDPRQMPKIHTKAVTGRTIFIIPRRSGPNTAPTVSSAFRAMNRLVREQKLRQKFHSQKVHLRPGMKRKILKSKRWRARFMEGFRAVASRAQELKRQGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L750</accession>
    <name>A0A367L750_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GRAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L750"/>
    <dbReference type="STRING" id="1330021.A0A367L750"/>
    <dbReference type="OrthoDB" id="1259151at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13214">
        <property type="entry name" value="PH-GRAM_WBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044852">
        <property type="entry name" value="WBP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606:SF1">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="257" mass="28984" checksum="DDDED1F0ACE5BF23" modified="2018-11-07" version="1">MDNPHDYLITSRAPPRRPANPDNADSWVMLNQSGFVKLGNERVLQKLESRISCELSVPQELRARCTQFLRKSDKGTLFLTNKRIVYLPLKPSQEPKFESFNAPILKFQDSSTSSSMLWGWVWKSDCLPVSGGGIPPDIPRIEVKFTFSDGGMTDFNEAYIRLRERLFQFQELRRETGGGADIPDEPLPAYEAQGASQPDASSVSHNPPRNIIRSDSSASRRAPNEPPPGYDEAQAQQISMRLEDHIREGVDRGEPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L771</accession>
    <name>A0A367L771_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_8542</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L771"/>
    <dbReference type="STRING" id="1330021.A0A367L771"/>
    <dbReference type="OrthoDB" id="4080456at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052772">
        <property type="entry name" value="Endo/PolyKinase_Domain-Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058864">
        <property type="entry name" value="UBA_10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535:SF1">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26286">
        <property type="entry name" value="UBA_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="3">
        <location>
            <begin position="125"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="domain" description="Smr" evidence="2">
        <location>
            <begin position="437"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="634"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI10072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="649" mass="71351" checksum="BDD5655FE298FC37" modified="2018-11-07" version="1">MAEPDLVQRLVGSFHALLDEALIVAIVGDYDLNHPASFDAAHSTLQRLAHNVPSEEATGFNPSGIPVPRDEVRDEAGEASTTSASLSRPTSQTIATDLSSVGSSSPAAEPLDIAKPRITSFDDDSEETKARLLQSMFCELREFDIKYSLKKANGDFQSALDDLLDMQYLQSTGQQVKGVDGFFDHEDDPSFNKKRRRKQKKRGASASDPTPSSQNEFIVPSNDEIDYIAERFNIRSDEVSGIYNKNQRSSGATVVELLDSYISHGVESQDDAGRQQADVLTRKYRNVPEKYLLTVVQVAGSISQFADDLAALLNKHFSRKPKSQKLDLGYRLTPLPRDDIEGGGDVVATVRELPARSSAAPGDFNHAVRLAHSHRQAERDAVASAARLHRSGASKPLYRQAASVYTEKARDQAKQAQQAASLAADLLVAQHSTDCSVDLHGVPVHDGVRIALQKTRDWWDDLGEFRAKKAKDQGFTVITGLGRHCAGGVSRMRQAVAAALLQDRWKLQVLTGMFVRAADHGDANETIVNRDVANARSRDERIEQICDEPGEEMDRNRRAQVKASAQRPTSHRTCASRSNLQASSAPQMATPSTPTRSNSVTDSTRPKMPSADCANTPSQPSDEERATPASKLPRNQKRRRVLRLRFSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7H2</accession>
    <name>A0A367L7H2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_4250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7H2"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI10377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="150" mass="17236" checksum="27D1DF3208B32BEC" modified="2018-11-07" version="1" fragment="single">LEQQAIAQSSRLKRKLLPPRSPFDSDKILFLARNIPYNDYARAVTRIRSIAINIKAFRLKARSNAKGAPLTTRALPLNLLPAIRDSLIPAAKQYRHFLKSCNLYLAHRLFISRMRFIDILTRYNVLVRASRRELIIYSADNLVIYGSAAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7N4</accession>
    <name>A0A367L7N4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_4277</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7N4"/>
    <dbReference type="STRING" id="1330021.A0A367L7N4"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008892">
        <property type="term" value="F:guanine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046098">
        <property type="term" value="P:guanine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051607">
        <property type="entry name" value="Metallo-dep_hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11271:SF6">
        <property type="entry name" value="GUANINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="6">
        <location>
            <begin position="82"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="425"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="489"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="428"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="491"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI10430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="511" mass="56539" checksum="33BA19E8C48513A9" modified="2018-11-07" version="1">MASPWELDKFQVFLGTFVHSKTREELEFLHDSAVAVDRQGQIVGIKSGFGSVTEAKEKLLESLGLQEKDVEVCECGKGKFFFPGFIGQHTHVHAPQYPNVGIFGKSTLLDWLQKYTFPLEASLKDLKKARRVYGACVRRMLAHGTTMAAYFATIDVAATNLLADLCLALGQRALIGRVCMDAPAINPDYYRDESAEESLRSTRQTVEHVRRVDGGRGIVTPILTPRFAPSCSSEAMNGLASMQRELDLPVQTHISELVDDVKLATSLFPHAGSYAKIYDDHGLLTDRTILAHAVRLTDGEAMLVAARRSKVSHCPCSNGCLTSGKARVRWLWDCGIDVGLGTDMSGGFSPSMLEAARQAALASRYVAMDIVAGEEACERSKLTVEEVLYLATRGGAEVVGLADCLGRFEVGMQWDAQLVRLRLVGEGGSEEEEEEEEEEEEEEEEEEEAEDDGNNVDIFGWETWEDIMAKWLYNGDDRNTEKVWVRGRLVKTTTTKTTTTTTTKTKTKTTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7Y0</accession>
    <name>A0A367L7Y0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fatty acid synthase subunit alpha</fullName>
            <ecNumber evidence="3">1.1.1.100</ecNumber>
            <ecNumber evidence="4">2.3.1.41</ecNumber>
            <ecNumber evidence="2">2.3.1.86</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">L249_4284</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29 30">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a fatty acyl-[ACP] + malonyl-[ACP] + H(+) = a 3-oxoacyl-[ACP] + holo-[ACP] + CO2</text>
            <dbReference type="Rhea" id="RHEA:22836"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:14125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:138651"/>
            <dbReference type="EC" id="2.3.1.41"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H(+) = a long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.86"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 22">Belongs to the thiolase-like superfamily. Fungal fatty acid synthetase subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="29">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="3"/>
    <dbReference type="EC" id="2.3.1.41" evidence="4"/>
    <dbReference type="EC" id="2.3.1.86" evidence="2"/>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367L7Y0"/>
    <dbReference type="OrthoDB" id="4251012at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004321">
        <property type="term" value="F:fatty-acyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042759">
        <property type="term" value="P:long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00828">
        <property type="entry name" value="elong_cond_enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08950">
        <property type="entry name" value="KR_fFAS_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.20:FF:000005">
        <property type="entry name" value="Fatty acid synthase alpha subunit FasA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2490:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.25.70:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1930">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00101">
        <property type="entry name" value="AcpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002582">
        <property type="entry name" value="ACPS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040899">
        <property type="entry name" value="Fas_alpha_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047224">
        <property type="entry name" value="FAS_alpha_su_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026025">
        <property type="entry name" value="FAS_alpha_yeast"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041550">
        <property type="entry name" value="FASI_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004568">
        <property type="entry name" value="Ppantetheine-prot_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00556">
        <property type="entry name" value="pantethn_trn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18325">
        <property type="entry name" value="Fas_alpha_ACP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18314">
        <property type="entry name" value="FAS_I_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000454">
        <property type="entry name" value="FAS_yeast_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 24" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 24" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-0521">NADP</keyword>
    <keyword evidence="14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6 22 25" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 22" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="27">
        <location>
            <begin position="138"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="28">
        <location>
            <begin position="1091"/>
            <end position="1628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="97"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="578"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="26">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="active site" description="For beta-ketoacyl synthase activity" evidence="23">
        <location>
            <position position="1274"/>
        </location>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1745"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1746"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1747"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1845"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="1846"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="O-(pantetheine 4'-phosphoryl)serine" evidence="25">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00049541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRNR" id="PIRNR000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="PIRSR" id="PIRSR000454-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PIRSR" id="PIRSR000454-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PIRSR" id="PIRSR000454-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="RCI10537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1859" mass="204542" checksum="08F141141526D555" modified="2018-11-07" version="1">MRPEVEQELAHTLLIELLAYQFASPVRWIETQDVFLAERTAERIVEVGPADTLGVMAKRTLASKYEAYDAAKSVQRQILCYNKDAKEIYYDVDPVEEEPEPAAASSGGSAPASASAPAPVTAAAPPPPSSGPAAQVPDQPVQAIDIIRALIAQKLKKPLLEVPLSKAIKDLVGGKSTLQNEILGDLGKEFGSTPEKPEDTPLDELSASMQATFDGNLGKQSQSLIARLISSKMPGGFNITATRKYLESRWGLGPGRQDGALLMALTMEPPARLSSDGDAKGFLDEVTQKYAANAAITLSTASAGGAPGASGEGMMMDPAAIDALTKDQRALFKQQLELFARYLKMDLRSGDKAFVGSQKSEKLLQAQLDLWAAEHGEFYASGIEPVFSPPKARTYDSSWNWARQDALSMYFDVIFGRLQAVDREIVSQCIRIMNRSNPKLLDFMQYHIDNCPTDRGETYKLAKELGVQLIENCRDVLNVSPVYKDVAVPTGPRTTVDARGNLNYEEVPRASCRKLEHYVQQMAEGGKISEYGNRTKVQSDLQRIYRLIKQQHKMSKTSQLEIKNLYGDVLRSLAMNQSQILPKENGKNKRSSVKGPPNHTKGNVETIPFLHLKRKSLHGWDYSKKLTAIYINCLEDAAKSGVTFQGKHVLMTGAGAGSIGAEVLQGLISGGARVVVTTSRFSKEVTEYYQSMYSRYGSRGSQIVVVPFNQGSKQDVEALVEYIYDTKNGLGWDLDFIVPFAAISENGRQIDSIDSRSELAHRIMLTNLVRLLGCVKTQKADRGFETRPAQVVLPLSPNHGTFGNDGLYSESKLALETLFNRWYSENWANYLTVCGAVIGWTRGTGLMSGNNIVAEGVEAFGVRTFSQQEMAFNLLGLMSPIIVDLCQAEPVFADLNGGLQFIPNLNEAMTKLRKDLMETSEIRRAVAKESAIENTIVNGAESEALYKKKTVAPRANIKFDFPPLPEWKSDIEPLNATLKGMVDLDKVVVVTGFAEVGPWGNSRTRWEMEAYGEFSLEGCVEMAWIMGLIKNHNGPLKGKPYAGWVDAKSGDPVDDKDVKSKYEKHILDHSGIRLIEPELFSGYDPNKKQILHEVVIEEDLEPFEASKETAEEFKRQHDDKVEIFEVPDSGEYIVRLKKGASLWIPKALRFDRLVAGQIPTGWDPKRYGIPDDIISQVDPVTLYLLVSTAEALLSCGITDPYEFYKYVHVSEVGNCVGSGMGGAAALRGMHKDRFLDKPLQNDILQESFINTMAAWVNMLLISSSGPIKTPVGACATAVESVDIGYETIMEGKARVCFVGGFDDFGEEGSYEFANMKATSNTVDEFAHGRTPQEMSRPTTTTRNGFMESQGCGIQIIMTAKLALDMGVPIYGVLALTTTASDKIGRSVPAPGQGVLTTAREHAGRFPSPLLDINYRRRQIERRKKQIKQWQESELEFIQDEIEAMKVQDASFNQDLYAQERMEHIRREAARQERELLRSMGNNFWKNDPSIAPLRGALATWGLTIDDLSVASFHGTSTKANDKNESSVICQQLRHLGRKKGNAVLGIFQKYLTGHPKGAAGAWMMNGCLQVLNTGLVPGNRNADNVDPVMEDFDLIVYPSRSIQTDGVKAFSVTSFGFGQKGAQAIGIHPKYLFATLDEAVYGDYCAKVAARQKKAYRFFHNGLINNSLFVAKANAPYTEDQLRNVLLNPDARVTEDDKTSELKYAENFMKQSEKTMPASRASETQKMMEALALKVASKSSKIGVDVEDIAAINIDNDTFLQRNFTAEEMKYCQSAPSPRSSFTGRWSAKEAVFKSLGVASKGAGAAMKDIEVLKDDNGAPKVKLHGEAAAAARKAGVKDITLSISHSDTQAIAVAVANF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L800</accession>
    <name>A0A367L800_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_4485</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L800"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI10545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="100" mass="11461" checksum="16B54BB2DA8288D5" modified="2018-11-07" version="1">MPAAKRYNRVEDINSSLATQFKEIKRDINTAPLLFPILINSTTFIDAQADYSYNCYAAISKSLLMRYNVLVRASRRKLIVYSANDLPARDLISALYYPYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-05-03" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8H7</accession>
    <name>A0A367L8H7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_4281</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8H7"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI10532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="131" mass="15205" checksum="ECCE9E7757E181DE" modified="2018-11-07" version="1">MEGKEKKSKENLISELVHASFRGKEIRVPFFFSPRDALSRWVRLVKAEMCKEGGRWVRFRYLTGYISARTEMIRLQEGISRAAHPSPIDERNNQTDAFSAFITQRSKASCNERRYSYTATTQPESKCQPHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8P1</accession>
    <name>A0A367L8P1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5426</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8P1"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI10793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="54" mass="6501" checksum="53A326A898440298" modified="2018-11-07" version="1">MDKELTNREEAIKEELEAGEVFVLRRYFSRYFKVPTCSTLTYLYRKTCTYPTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L983</accession>
    <name>A0A367L983_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Lysophospholipid acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_5351</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L983"/>
    <dbReference type="STRING" id="1330021.A0A367L983"/>
    <dbReference type="OrthoDB" id="286734at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046474">
        <property type="term" value="P:glycerophospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030258">
        <property type="term" value="P:lipid modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049941">
        <property type="entry name" value="LPLAT_7/PORCN-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906:SF4">
        <property type="entry name" value="LYSOPHOSPHOLIPID ACYLTRANSFERASE 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13906">
        <property type="entry name" value="PORCUPINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="474"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI10979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="563" mass="63753" checksum="8DCCADA963966D0E" modified="2018-11-07" version="1">MLQFLHRPFEGLAASFGASPDEGESHLPSRYNRTWLLTKDGSIWGLPVKIIVSFLLSYPLAGVLKRIPDSKPQYKNLFIIGMSIFYMVGLFDLWRGLATLFFSAAGAFCIAKYLQKSSYMPWVGFVFLMGHMSFSHIRRQIANNPSAVDITGAQMVMVMKLSAFCWNVADGQLPSDGLSEHQKDRALSALPSPLDYAAYVLFFPSLFAGPAFDYVEYRRWIDTSMFDVPAEVDSAKRPPVRKKRKIPRSGTPATFKAIQGLCWIGLFVALSARFGYEQLVDESYMQYGFLRRVWIMYMANVVARLKYYGVWSLTEGSCILAGLGYNGVDPVTGKVSWNRLQNINPWMVETAQNPREYLAGWNMNTNNWLRNYVYLRVTPRGKKPGFRASMTTFATSALWHGFHPGYYLSFVLASLVQTAAKNFRRLVRPFFLDPVSGDPRPGKKYYDAVSYVATQSTFAFVTTPFLLLTLKSSIHAWSCVYFYALVWTLACMLFFASPGKGILKRELEKNSGQPRPKLVRSISVESLKGKEPILGISKDLEQDMTEAVEEIRAEVQARQRKMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9B0</accession>
    <name>A0A367L9B0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_5252</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Fluoride channel required for the rapid expulsion of cytoplasmic fluoride.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>fluoride(in) = fluoride(out)</text>
            <dbReference type="Rhea" id="RHEA:76159"/>
            <dbReference type="ChEBI" id="CHEBI:17051"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:76160"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI11013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9B0"/>
    <dbReference type="STRING" id="1330021.A0A367L9B0"/>
    <dbReference type="OrthoDB" id="409792at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="FluC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="FLUORIDE EXPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259:SF1">
        <property type="entry name" value="FLUORIDE EXPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="74"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="219"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="322"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI11013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="420" mass="45085" checksum="7A321E7465AD171C" modified="2018-11-07" version="1">MGLARGSGELASHGTQCAPSDETWATVDGTLAASRPVEASPTRTDSLEATRRRRRSRSSGRASPRRREVVVSRLVTQLYTLSHLVSFSLFGTLARLGLSSLTRFPGAPVIFSSVWSNFAGCVVMGFLAEDRRLFRHEWGEASSSSASSSSPGPEAAKAHLAAKKTIPLYIGLTTGFCGSFTSFSSFIRDVFLAMTDDLYWPVTAEVRIPGEGGRSSGRAFMALMAVVIATVSLSLSGLFMGAHLALATEQILPSLPQPGTRRYVDPIGAVLGWGCWLGAVLLCALPPRDEWRGVLFALVFAPLGTLLRFYLALWLNGRQPAFPLGTWTANMLGTAVLAMAWDVAHVPIGGVVGCQVLTGVGDGFCGCLTTISTWAVELNSLRRRHAWVYGVVSVVVAFALLVLIMGAFRWTHGFAMLECH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9B9</accession>
    <name>A0A367L9B9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LDB19 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_5259</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI11018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9B9"/>
    <dbReference type="STRING" id="1330021.A0A367L9B9"/>
    <dbReference type="OrthoDB" id="3832628at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024391">
        <property type="entry name" value="LDB19_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13002">
        <property type="entry name" value="LDB19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LDB19 N-terminal" evidence="2">
        <location>
            <begin position="134"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI11018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="539" mass="60041" checksum="0F8593F893391930" modified="2018-11-07" version="1">MPHRVTNFLPSSASSASASASASSPKSDSDKRNNIAFIMPRNHLNHHHILSLPFSLLTKDHHHHHHHHHHPHYHRPHLSPHHSPVRLDWSIESPPIVFHGSPEESTGALISGQMLMDVSEDSVQVQGFSASLSLRLTQKRPYQGHCCDCQHQTRELKSWRLLTKPATLTRGRHLFPFSALLDGRLPACLDTSVVVIEYVFKAQAILGRPHGRPPVCIGFSRFLDVKRSLPEPLYPHHSVRVFPPTNIKASAHYSSVIHPTSSNPMTLKLDGLMSRNVKTGTVDIWRLKKVTWRLEETIKTYAPACQRHAPPSSSSSSRSSTSASSASASSSSAHADDDDDDDADDDDDEEEEEEEDDDDDDEDDDDDDDDDMDDDEHSSDASTSSNDGGKKRICRVSTRTLREKQLHNGWKSDFSGCDGTVDMEFNFGVPVSKPHSREPTYACDTKTRDGTEVTHSLLIELIVSKEFAPEGKPQLATQTGTGRILRMHFAVVMTEFPGLGVSWDNEAPPVYQDVPPRPPGYPYEPPIEYDQLEALDARA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9G3</accession>
    <name>A0A367L9G3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycosyltransferase family 25 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_7386</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9G3"/>
    <dbReference type="OrthoDB" id="47375at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050757">
        <property type="entry name" value="Collagen_mod_GT25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730:SF53">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730">
        <property type="entry name" value="PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE/GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI11071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="404" mass="44852" checksum="A7BC8BF19B4AE3C6" modified="2018-11-07" version="1">MKISISYAWPTARCVRLTALALSAVLGLIIISWIGGENFTSSSAFNRSGIREPSRSSMRKPNWEENWERRVMDLSALTDLGRVANRTLGFEKVIAIGLPERSDKRDALDLMAALSGFDLDWVDGVKSSDISKKAIPFGIDLKTVHDNFLGGWRGHMNAIRRVVNSGVSSALIMEDDMDWDVHLKLQLNEIAQGVRQVLGEFSPHLPKSPYGDSWDVLWLGHCGEPFPETLEENVGLEDEAKARMSVKHTIIEDNTVPPYSEVSHLVDWSAFSARTRLVHLSAAPICSFAYAISQSAARKILFALSVDGLQMAFDNSLAQLCRDSIHDLGLQKEDGYRLRCLSVNPTMMFHHRAKGLLLGDSDVQSSGQDGSAREQGISESIKWSMRLNLRNILTGQPLDPQFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LA35</accession>
    <name>A0A367LA35_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7223</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LA35"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI11273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="166" mass="18354" checksum="93A623D564DA3CB6" modified="2018-11-07" version="1">MGGDGIADDEKMGRKSVVSICNDITDGSRLYVCTYIDKHQALDERTNARFQLLVPIHEASLHQLSCHRASHGIRISRSPKLKQAASGRYHRGGKQTQDKMFVRSSLAGLTPCDLQKQSPGPACLPLPEESCYQAHPNMGVREAWDDWFQEAAPSPNPRLSMGKSAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAU9</accession>
    <name>A0A367LAU9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7787</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAU9"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI11372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="68" mass="8151" checksum="9057C937B7C3A8A1" modified="2018-11-07" version="1" fragment="single">KIRYKDIRTFSKKKGEFNAFLTNLKDKIRTNKATFRDKEDRIGFLFRSLKGKACKTLKTYYIKDSVYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LB13</accession>
    <name>A0A367LB13_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Anaphase-promoting complex subunit 4 WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_7516</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LB13"/>
    <dbReference type="STRING" id="1330021.A0A367LB13"/>
    <dbReference type="OrthoDB" id="1930760at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061685">
        <property type="term" value="F:diphthine methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052415">
        <property type="entry name" value="Diphthine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042:SF1">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI11605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="388" mass="42013" checksum="C737D6B84F9765F1" modified="2018-11-07" version="1">MATISPKTSLTLHLPPSCLQTCPFDPAYFVVGTYNLHQAAESEMAQSRDGSLVLFRIGDDDGITEAQTVPQPSAVLDVRFHPRQGDHQGILAAVSSTSTLAIFRLDSTRRLRQVATSRVRGMANDVLFLQCVWHPVLDHVIAVTDSRGAARLLHLDGGWNITACTDLDIGNSLEAWSIAMSPPLEMDDHDQAVIVYCGGDDCSLRHTLCSPDLQIPYAPVTIKGQHDAGVTAILPLPLHAADGGRLVVTGSYDDRMRVFAVDDLGRQHTVKRPRLVCDTNLEGGVWRLSLVDTQLRIDGLRRARILASCMHAGPKLVELTGEADGLRWVCKASARFDGHNSMNYASDCVVAEGGESLRCVSTSFYDKLLCLWVVGGGDDKADGVSSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LB56</accession>
    <name>A0A367LB56_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7217</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LB56"/>
    <dbReference type="OrthoDB" id="4903230at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI11660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="207" mass="23697" checksum="896517FD0CB470B4" modified="2018-11-07" version="1">MEAFIQRNNFVEVSLPLFVKPGEPMKPPLLVSFREQRSEGNQPHMYQARLILSSIDGKPQDPRAPPPLAQIIEGEFTTALTVKMTDKLWFLFGDLTFKPETAGHSYRFAVQLWTCWYDRPNKSWEPAMYQCEIETGTIVSCDKTVWTEDPETTKWDEAQAQAIRELAVKQPLATVAEMTNKFPRTTLHEDLLKGPWASPDRPSKRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LBI6</accession>
    <name>A0A367LBI6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF4219 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2017-10" db="EMBL/GenBank/DDBJ databases">
            <title>A genome scan of diversifying selection in the zombie-ant fungus Ophiocordyceps unilateralis complex supports a role of enterotoxins in coevolution and host-specificity.</title>
            <authorList>
                <person name="Kobmoo N."/>
                <person name="Wichadakul D."/>
                <person name="Arnamnart N."/>
                <person name="Rodriguez De La Vega R.C."/>
                <person name="Luangsa-Ard J.-J."/>
                <person name="Giraud T."/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LBI6"/>
    <dbReference type="OrthoDB" id="3599317at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14223">
        <property type="entry name" value="Retrotran_gag_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI11771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="87" mass="10079" checksum="A7A8FC36522D49C7" modified="2018-11-07" version="1" fragment="single">MPNTEKITFAKLSGGDNYTYWALRMDSLLIRETEEALALIRLQLEDGPLTQIMHIKTASEAWNRLKELYNPVSFTSNFLLTKELLEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LC89</accession>
    <name>A0A367LC89_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_0535</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LC89"/>
    <dbReference type="STRING" id="1330021.A0A367LC89"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF28">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE MINIBRAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="18"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI12035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="277" mass="31115" checksum="1E3B098689B5966A" modified="2018-11-07" version="1">MYAFQKTPPSKTNSCISFQVPNEADDTSYQAVSIRARAGDLPHTADRLWKRLYIRGIDDDLERLHGYRPGGYFPIHIDDELHDGQYRIVHKLGHGGSTRRHTSPSRFLSPARRETNLKDQAKAKQFVSQSPNGTHLCLVFPAVRLQIAQEVSRQTVENLALLHSRGICHGDLRPSNALLELQASDGLIIDFGQSFDTSQCLWHSGQLRGTRGRHRSFSCHDCAGLNCAHQRFQLISEAEAAALADLLEKLLRYQPEDRLAAQDVLKHAWFHTTSTAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCI9</accession>
    <name>A0A367LCI9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Proteasome alpha-type subunits domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_0388</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCI9"/>
    <dbReference type="STRING" id="1330021.A0A367LCI9"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03750">
        <property type="entry name" value="proteasome_alpha_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000048">
        <property type="entry name" value="Proteasome subunit alpha type-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4 7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="162"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI12148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="32029" checksum="C60E50DDBE5BF8E9" modified="2018-11-07" version="1">MADRYSFSLTTFSPSADRYAYSCLYTNHADAILTRIRTEYALNAVNQGITALGIKATNGIVLATEKKSSSPLADQSSVDKISIINPNIGAVYSGMGPDYRVLVDRARKVSHTGYKRIYNEYPPTRILVQDVARVMQEATQSAGVRPYGVSMLIAGWDEGIEPEGKEEKPTEGEKTSSSKKTGGILKGGPMLYQVDPTGSFFPWKATAIGKSATKAKTFLEKRYSEELELEDAIHIALLTLKDNIEGEMNGDSIEIGIVGPPADHLLGIEGVEGATGPRFRKLTPQEIEDYLTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCR6</accession>
    <name>A0A367LCR6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">RNA cytidine acetyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">18S rRNA cytosine acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">NAT10</name>
        <name evidence="17" type="ORF">L249_1351</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein TAN1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in 18S rRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51424"/>
            <dbReference type="Rhea" id="RHEA-COMP:13575"/>
            <dbReference type="Rhea" id="RHEA-COMP:13576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a cytidine in tRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in tRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53876"/>
            <dbReference type="Rhea" id="RHEA-COMP:13670"/>
            <dbReference type="Rhea" id="RHEA-COMP:13671"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with TAN1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
            <location evidence="1 11">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="11"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCR6"/>
    <dbReference type="STRING" id="1330021.A0A367LCR6"/>
    <dbReference type="OrthoDB" id="10067491at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990883">
        <property type="term" value="F:18S rRNA cytidine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051392">
        <property type="term" value="F:tRNA cytidine N4-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904812">
        <property type="term" value="P:rRNA acetylation involved in maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051391">
        <property type="term" value="P:tRNA acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11040:FF:000002">
        <property type="entry name" value="RNA cytidine acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002218">
        <property type="entry name" value="tRNA(Met) cytidine acetyltransferase TmcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03211">
        <property type="entry name" value="RNA_acetyltr_Nat10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033688">
        <property type="entry name" value="NAT10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007807">
        <property type="entry name" value="TcmA/NAT10_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032672">
        <property type="entry name" value="TmcA/NAT10/Kre33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013562">
        <property type="entry name" value="TmcA/NAT10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027992">
        <property type="entry name" value="tRNA_bind_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925">
        <property type="entry name" value="N-ACETYLTRANSFERASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925:SF5">
        <property type="entry name" value="RNA CYTIDINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13718">
        <property type="entry name" value="GNAT_acetyltr_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05127">
        <property type="entry name" value="NAT10_TcmA_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08351">
        <property type="entry name" value="TmcA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13725">
        <property type="entry name" value="tRNA_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TmcA/NAT10 N-terminal" evidence="14">
        <location>
            <begin position="5"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="TcmA/NAT10 helicase" evidence="13">
        <location>
            <begin position="282"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="15">
        <location>
            <begin position="537"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="Possible tRNA binding" evidence="16">
        <location>
            <begin position="775"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="436"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1053"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1066"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="638"/>
            <end position="640"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="645"/>
            <end position="651"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="740"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00052133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00068357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF05127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF13718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF13725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCI12214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1077" mass="120004" checksum="1229BBE6906A0566" modified="2018-11-07" version="1">MTRKQLDQRIQTLIRNGVQEKKRSFFLVVGDRSKDVIVYLHHIMSSMDVRQNKSVLWAYKKKLLGFTSHRKKREQKIKKEIKRGIREVNSEDPFELFVSLHNIRYTYYKETDKILGNTFGMCVLQDFEALTPNILARTIETVEGGGLVIMLLKGMNSLRQLYNLTMDVHSRYRTEAHNDVVARFNERFLLSLGRCESCLVIDDELNVLPISGAKDVQALPPPDLDQPKTPQQMELESIKDEYRETEPVGSLISLAKTVDQAKALLTFTEAIAEKTLRSTVALTAARGRGKSAAMGIAVAAAVAHGYSNIFITSPSPENLKTLFEFVFKGFDALGYADHADYSIIQSTNPDFNKAIVRVNVHRQHRQTIQYVRPQDAHVLGQAELVVIDEAAAIPLPLVRKLMGPYLVLMASTINGYEGTGRSLSLKLIKELREQSRAGSTAEGDSRLADRSTGRTAKAGEYQAARRLREIALTEPIRYAPDDAVEKWLNKLLCLDATLPKSKSKIHGCPDPSLCELLAVNRDTLFSFHPVSEAFLQQMVALYVASHYKNSPDDLQLMSDAPAHSLFVLVPPNVEDSGKLPEPLCVVQVALEGKISRQSVLNSLSRGERPSGDLIPWLVSQQFQDEGFASLSGARVVRIATNPEYVSMGYGSKALELLVDYYEGRFASISEHDDQGEEEKVHRATDAELAQTSLLEEEIAVRDQAKMPPLFAKLRERKAEALDYMGVSYGLTAPLLKFWKRGNFSPVYLRQTANNLTGEHTCVMLRPMENSADMGWVGAFARDFQKRFLTLLSYQFRVFTAATALSIDEAANKGAKLDAVDVGPLDKTELDRQFSPFDLKRLESYANNMLDYHVILDMMPAIATLYFTGRLKGNIKLGGVQQCILLAIGLQRKDIDAVGQELGLPSNQLLAMFIKMVRKVTTHLGCLVSAAVDAEMPRAEPVGVSRANASGAHDDERVDDGFNALEKPLEEELEEGGNEALQALRQKQRELVDSLPLDQFEIEGDATGWEAAEKQVRSATLEGRAEPVVSVRSSKLKRKAGGSTAAEVYQEVLGADERRRKTKRGRSSREGIEERRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCS7</accession>
    <name>A0A367LCS7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_1354</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCS7"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI12217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="313" mass="35486" checksum="2381D28D02ED7FCD" modified="2018-11-07" version="1" fragment="single">STKRTISVANRHGRDKSRSPWLLLAIPEKPSHQQVNAKTLVSSASNVVKERDDMGSGRRKVAGQGDARFLRLFDISPRIGILLESFPQMTTCGTAGLQRGGFFSAATRGYARIQPQRRTSAEAQKSNTTDGAVGDVNFDRMYFFLYQYHLSYCRKFRISNAYMAFACRDRNSPLLSIYDFSSLFRASSQTRIQRRIFCFFHSPSDITRISILPSIPFFKAVPKHNQPSHPVSPHPTRIINDPQLRLKMRANWPVSFLPKLKHTINSSPASPALFILPFASLLFYEIHSPPKLLAFQLPFFLFFPASFNLHVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LD55</accession>
    <name>A0A367LD55_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_1102</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LD55"/>
    <dbReference type="OrthoDB" id="4927619at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017042490" evidence="2">
        <location>
            <begin position="17"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI12341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="166" mass="16667" checksum="F128D8BB7E6BD271" modified="2018-11-07" version="1">MKLQIVALILASTCLAEFTSNDELRQIEAVTRDLETIAEAPGKGHLTKRAAACSLLCCHKKSFEGICAKCAGVCNGGGKTDDDDDDESPGQASSPVLIGVNKQNKGGQPSPGGFGGGRGTGSWGGGRPSGSWGGGGWGGGGWGGDGGNKDAWGQNSRDGGGWSGGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDE2</accession>
    <name>A0A367LDE2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L249_0987</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDE2"/>
    <dbReference type="STRING" id="1330021.A0A367LDE2"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12122">
        <property type="entry name" value="AMPKA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14079">
        <property type="entry name" value="STKc_AMPK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14334">
        <property type="entry name" value="UBA_SNF1_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000407">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000069">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000236">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032270">
        <property type="entry name" value="AMPK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013896">
        <property type="entry name" value="SNF1_UBA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16579">
        <property type="entry name" value="AdenylateSensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08587">
        <property type="entry name" value="UBA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="58"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="19"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="461"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="560"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="480"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="566"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCI12431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="709" mass="78559" checksum="909A2B475293DC80" modified="2018-11-07" version="1">MAPRGGFDDEELTISLSLSHVRRPRQHASSKPPASIRAGAMEAPLRDRSKAEQRIGAYKIVRTLGEGSFGKVKLAIHNGTGQQVALKIIARKKLISRDMAGRVEREIEYLQLLRHPHIIKLYTVIKTHTEIIMVLEYAGGELFDHIVQHGRMSESKARRFFQQMLCAVEYCHRHKIVHRDLKPENLLLDDHLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVIGGKLYAGPEVDVWSCGVILYVLLVGRLPFDDEHIPSLFAKIARGTYSIPPWMPAGAASLIKKMLVVNPVQRATIEEIRQDAWFVTELPAYLQPPVEEFLNTGVDPNKAIEKRDIAPNAPVQVQEKLHNEVTDKISKTMGYGKNDVEEALQSEEPSAIKDAYMIVRENKMMQVNQNADSQAVESAEASSPMMSMSSARSALSQSGVVPRLHVSKVGILPSSLPAYHKDFMERKMAEGDGEAATAADPDEPTSARTDAEKEEAVRRLRPHARSQLRLEDGAKRPSGMTPMNPTKKPKPVRWQFGIRSRNAPWEALLCIHKALYKLGATYTPDEDYAQKGSEAAGGGGGGGDDFGDDYDEGAPLQRGESAAEMDPAKRYKLPADPWHIRVRWESSGIDGAQVAGRLGHAGELPRVLAPSWRQQKSFVALHLDIQIYEMEQGVYLVDFKCSGYETADGMLLDEKEVTSPFPFLDMAAKLIMQLAEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDE3</accession>
    <name>A0A367LDE3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_1142</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDE3"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI12448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="66" mass="7900" checksum="F5C5386A61A5D063" modified="2018-11-07" version="1">MYVDCSINSLTWNAVAKLKRVVKKGWPKLRSRQESPELDLRSSISFFFFEHLFFTWMAYPARIVEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDL1</accession>
    <name>A0A367LDL1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_0605</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDL1"/>
    <dbReference type="OrthoDB" id="4920915at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI12506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="194" mass="22296" checksum="7F8193EC62A6AECD" modified="2018-11-07" version="1">MYKKRVPATYHLSVTSERYSSVFPWPIGNRFPLPLLLPTMKLLRMQTFLLLVLTTTTVAYQNDDEYIRCKQLLPRNSCLAELYYVFKTQGRSLTRACQPGGILGSNEPFVFSRIEMRGLGRHPVCAHFTWEFGRSRPIVGNDYFIRAEEYGVICDDSVNGLKLLLTVGGKVLLGFDEVFMHLYRSFPFTNPPIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDL5</accession>
    <name>A0A367LDL5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAM86 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0352</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDL5"/>
    <dbReference type="STRING" id="1330021.A0A367LDL5"/>
    <dbReference type="OrthoDB" id="433955at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF156">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EFM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="434" mass="48129" checksum="FAFC106C9644A1EF" modified="2018-11-07" version="1" fragment="single">IAPIWQRPSLSTLVETLEALELRPPSWDEHRRRRRRRRRQRRRSSSSPSSSSSSSSSSSASPVRGAMEKETRYLATIIKSPLGWISDDEGDRERVWELASKRMAERCGRTAMGDVVRPWVVGDTVELVIGEPGLTGDEALGFKTWASSFVLARHLTRLADVIGIGKELGTRPRVLELGAGTGLLGLSAAALWRTEVVVSDLPRIVPNLGKNVQQNGPLIRARGGSVAVGSLTWGGGADDDEALFGEPFQFDVVLAADALYDDHHPRLLASAIDGHLAARQDRDAARAVVIVPKRDVATMKLVDDFRTEMAGLDLFCCREEELLGRDDWGGVEDWEVGDEDEDEDEGKDAVRCWLAFLTRPVRANLNPNQAPRRLPLQAATSIIRPSRMPNAPNSRTYSRLDSRSYSHSYSRLDNSPYSRTYSRTRGVSHELAHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LE43</accession>
    <name>A0A367LE43_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Letm1 RBD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_0667</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LE43"/>
    <dbReference type="STRING" id="1330021.A0A367LE43"/>
    <dbReference type="OrthoDB" id="275278at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033122">
        <property type="entry name" value="LETM1-like_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044202">
        <property type="entry name" value="LETM1/MDM38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009">
        <property type="entry name" value="LEUCINE ZIPPER-EF-HAND CONTAINING TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009:SF1">
        <property type="entry name" value="MITOCHONDRIAL PROTON_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07766">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51758">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Letm1 RBD" evidence="10">
        <location>
            <begin position="242"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="40"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="470"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="507"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI12693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="528" mass="59208" checksum="287B70350B214C6A" modified="2018-11-07" version="1">MSVSSAVARRAAAASARNPLPMVGSASGVFAPRWLARRDALFESPPPPGFNVEQAKKPLAREGANGDISSQQQQQQQPQQQPQQNLPNHQQSQHQLQQAKNQHEQAGATKTEATVVKMAANKGDGAEKQELVKADQEDKKLTLWQKVKREAQHYWDGSKLLAVEVRISWKLALKMAAGYDLSRRENKQLQRTVRDLGRLVPFSVFIIVPLGEALLPLALKLFPNMLPSTFEGQKSKDAKASLLRSTRNEVSAFLKQTLKETGLPLSAATAHKEEFANFFRKVRSTGETPTRDDVIRVCKVFRDDVTLDNLSRPQLVSMCRYMNLNTFGTDMMLRYQVRHRMRQIKRDDKAISFEGVDSLTVSELQTACAARGIRTHSVSPARMRTDLQTWLDLRLREGVPSTLLVLSNAYMYGQGSESEWNQVDALIGVLSSIPEELFHEMELEVHNAEGAATNKQRLEVLKEQQELIEDENEQNEESQSTGMATPRDVDDIDEKEERQLSAQAAGLEKKPAAEMVDAEREVCKPDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LE71</accession>
    <name>A0A367LE71_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LE71"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="186" mass="19593" checksum="2D6E0072BEC052C3" modified="2018-11-07" version="1">MSSKARLKQDEFPKMQAHDENEMKPKPDEDGMEVRFKRSFKNPASNGEKQVSVFLQKGKGQQSSETRQGEGLGIQRAGGADHLGGGEGSGGGGKPVGGGVGDDGLAIVVGLTRERKMVLTRRVVDVCVVVEGGAVPTAALPAGAAYWAMLKAGMATAKAERRMSTAVGEQVFEQRASCSSEQRKGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEF5</accession>
    <name>A0A367LEF5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Btz domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L249_1025</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CASC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEF5"/>
    <dbReference type="STRING" id="1330021.A0A367LEF5"/>
    <dbReference type="OrthoDB" id="5413466at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018545">
        <property type="entry name" value="Btz_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09405">
        <property type="entry name" value="Btz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01044">
        <property type="entry name" value="Btz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="10" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Btz" evidence="14">
        <location>
            <begin position="133"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="474"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="579"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="82"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="153"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="586"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="597"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCI12612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="728" mass="78288" checksum="DB6C9A26F3948252" modified="2018-11-07" version="1">MAAVAAAAATAAPRRRRIGRRRRVEDEGDDDGRAEPLDLDDESLSDGSFLTDDDDAGEDSDTSNIDEASPTSPAVRKSANGAPKSASAACPQPPAAASDTDMMLHGLSVADRPGPAQNIHFDDAVVSPPRSPSAPVVVSSSSAARQPPPASQGDRRRQEHEDYKRRRDVDPAFVPNRGSFFMHDHRHAGPSSNGFRPFGRGRARGGRGGIGGPFSPFSHVPNPSDPTTSSPWTHDMHDIVADPTPRHPRHMQQQCEGPPNGNGFIPTCEPSSTPINRTLSTEKHVGNAQVRVYLPHLTKGPTAFPGIPIKQYTKLPDHRPPLRRDKPVRISLPDHPPRYVFPASDRSFTFIPRAMRPNQQRMRGKPRSAWGSAGGFSRRTSILGGGSYYGSVYTPSIALSRRSSVVAHDRDVVFSPTGSAISRPAMPVDVARPVVRLPPASRPPVMVMPEAVMEPATHPFDMPMAVHEASSINDLPQPQMHPLPQKPAVQENRPGSLPMYQPRPQKNISVADIESPSLAQGPQAFHQPFHQQVPVPLQVPNGLAEAEVHTRGPASYTSQHSKGTPLSQIPERAIHAAPFQPNTSFGQPAYYAGQPQAYPPPPPPQAPPTQQGFYYPQAFAGPVHSMGPSAAAAPPFVPGGQHGFAGQAEQQVNVTQTASASATSSNLVAQEVNGMVYYYDTSQMQTFPPYAGHHGFQPGVISMGGMVTPSPDGFFYPQHAPGVVYYSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LF44</accession>
    <name>A0A367LF44_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Repressor of RNA polymerase III transcription MAF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_0992</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mediator of diverse signals that repress RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LF44"/>
    <dbReference type="STRING" id="1330021.A0A367LF44"/>
    <dbReference type="OrthoDB" id="277029at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000994">
        <property type="term" value="F:RNA polymerase III core binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016480">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1000.50:FF:000004">
        <property type="entry name" value="Repressor of RNA polymerase III transcription MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.50">
        <property type="entry name" value="Repressor of RNA polymerase III transcription Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015257">
        <property type="entry name" value="Maf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038564">
        <property type="entry name" value="Maf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504:SF0">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09174">
        <property type="entry name" value="Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037240">
        <property type="entry name" value="RNA_polIII_Trep_MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="322"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="327"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI13043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="385" mass="43287" checksum="F1669D72BD4E716F" modified="2018-11-07" version="1">MKYLPVRDFEAVTGALNFNTPDCNVTGGCDLYTTKSAGSDKKLYKNIDQDLNSQHAALLKLGASLSPPDREHMLATSPSIQLFSTSSAFGPLSELSSRRTFAYLIATLNASHPHYDFSHVLRPGDFKRERNLRRVMVNLDSILQNVRPASDASSSVDYSSLAADAAPVWGARCWSLIDKEMRLNECTIFSYRPDPDPFEEDESAIWAVHYFFFNRALKRVAYLYVRVVPVISSTSPTQRPAMTTSLAGGSQQNKRHLVEFGGDAYEGANKRARYWLGDRNAQLVPPYEDDDDGLIWNRGVDGDIVPFSDDDYFKDLDYELQLGQGGQDDDEEEEEEEEEEEEEEEEDGGGGEEGEEERYEDDEGHVLDKGHDRSMSEDIAGRMEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFA8</accession>
    <name>A0A367LFA8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Urease</fullName>
            <ecNumber evidence="2 9">3.5.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 9">Urea amidohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L249_0448</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>urea + 2 H2O + H(+) = hydrogencarbonate + 2 NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:20557"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Ni cation</name>
            <dbReference type="ChEBI" id="CHEBI:25516"/>
        </cofactor>
        <text evidence="11">Binds 2 nickel ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10">Carbamylation allows a single lysine to coordinate two nickel ions.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.5" evidence="2 9"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFA8"/>
    <dbReference type="STRING" id="1330021.A0A367LFA8"/>
    <dbReference type="OrthoDB" id="1708534at2759"/>
    <dbReference type="UniPathway" id="UPA00258">
        <property type="reaction ID" value="UER00370"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035550">
        <property type="term" value="C:urease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009039">
        <property type="term" value="F:urease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00375">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00407">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00390">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.280.10:FF:000001">
        <property type="entry name" value="Urease subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.150.10">
        <property type="entry name" value="Urease, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.280.10">
        <property type="entry name" value="Urease, gamma-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01953">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008221">
        <property type="entry name" value="Urease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011612">
        <property type="entry name" value="Urease_alpha_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050112">
        <property type="entry name" value="Urease_alpha_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017950">
        <property type="entry name" value="Urease_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005848">
        <property type="entry name" value="Urease_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017951">
        <property type="entry name" value="Urease_asu_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002019">
        <property type="entry name" value="Urease_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036461">
        <property type="entry name" value="Urease_betasu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002026">
        <property type="entry name" value="Urease_gamma/gamma-beta_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036463">
        <property type="entry name" value="Urease_gamma_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009671">
        <property type="entry name" value="PRK13192.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009686">
        <property type="entry name" value="PRK13207.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01792">
        <property type="entry name" value="urease_alph"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00192">
        <property type="entry name" value="urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00193">
        <property type="entry name" value="urease_gam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43440">
        <property type="entry name" value="UREASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43440:SF1">
        <property type="entry name" value="UREASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00449">
        <property type="entry name" value="Urease_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00699">
        <property type="entry name" value="Urease_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00547">
        <property type="entry name" value="Urease_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001222">
        <property type="entry name" value="Urease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01752">
        <property type="entry name" value="UREASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51278">
        <property type="entry name" value="Urease, beta-subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54111">
        <property type="entry name" value="Urease, gamma-subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00145">
        <property type="entry name" value="UREASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51368">
        <property type="entry name" value="UREASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9 11" id="KW-0533">Nickel</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Urease" evidence="15">
        <location>
            <begin position="399"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="14">
        <location>
            <begin position="719"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="12 13">
        <location>
            <position position="590"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="11">
        <location>
            <position position="487"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" description="via carbamate group" evidence="11">
        <location>
            <position position="487"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="489"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="516"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="542"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="630"/>
        </location>
        <ligand>
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="10">
        <location>
            <position position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR001222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001222-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001222-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR611612-52"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCI13091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="836" mass="89238" checksum="F40DA9DC23EB9CF0" modified="2018-11-07" version="1">MHLVPKELDKLLVSQLGFLAQRRLARGVRLNHTEATALIANNLHELIRDGNHSVADLMALGATMLGRRHVLPAVCATLREIQVEGTFPTGTYLVTVHNPISSDDGDLRRALYGSFLPVPDNEAFPLPADAEYLPHLRPGAVVAVKGRIAINGNRRRIRLRVTSRGDRPVQVGSHYHFVEVNAQLEFDRARAYGFRLDIAAGTSVRFEPGDTKTVTLVEIGGAKVIRGGNGLASGPVDELRAADIVERLQAAGFAHRPEPIGDAAHIDVFQMDRAAYAAMFGPTTGDLVRLGNTNLVVRVEHDLTWYGDECKFGGGKTLREGMGQASGRTDADSLDLVITNALIVDWSGIYKADIGVKKGVIVGIGKAGSPDVMDGVTPGMVVGSCTDVVAGEGKIVTTGGIDTHVHCICPQQVDEALASGITTMLGGGTGPSAGSNATTCTPGRHYMRAMLRAADALPVNIGFTGKGCDSSPEALREQIEAGACGLKIHEDWGATPAAVDACLRVCDEYDVQCCIHTDTLNESGFVETTLAAIAGRTIHTYHTEGAGGGHAPDIISVVEHANVLPASTNPTRPFTRNTLDEHLDMLMVCHHLSRNIPEDVAFAESRIRAETIAAEDVLQDAGAISIMSSDSQAMGRCGEVILRTWNTAHKNKAQRGPLEGDDAATGADNIRVRRYVSKYTINPALAQGMAHVVGSVEVGKLADLVVWDPAWFGTKPSLVLKGGFIAWAQMGDPNASIPTVQPIIGRPMYAPLVPESKILFVSGSCISSGTADSYQLRSKVEAVRGCRNVSKRDMRFNDAMPRMRVDPESYAVEADGLPCVAAPAESLPLSQAWYAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFL9</accession>
    <name>A0A367LFL9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="6">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_0176</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="6"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFL9"/>
    <dbReference type="STRING" id="1330021.A0A367LFL9"/>
    <dbReference type="OrthoDB" id="333239at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02657">
        <property type="entry name" value="Peptidase_C19A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16104">
        <property type="entry name" value="Ubl_USP14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044635">
        <property type="entry name" value="UBP14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982:SF1">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="4"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="9">
        <location>
            <begin position="109"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="379"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="406"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI13211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="559" mass="61526" checksum="CC548DED1022A1C1" modified="2018-11-07" version="1">MATVKIVVKHQGKKHDVEVDPASTGEDFKLQLFSLTSVEPARQKILIKGAQLKDDADMGKMGLKAGQVIMMMGTSSSGDGTLVRPKDPVKFIEDMTEAEKAQQMDATPAGLVNLGNTCYLNSTLQALRSLPEMSNALIKYKPDASDITSVPNDVNLAFHLSRLYARMGRTQAAFPPVEFLNALRTAFPQFAEKSKSDNGFAQQDAEEAWSQIVQNMRSRLKANNAAGTSSVPLIDTYMSGQLTSTIECQDEEARQAGEEAVVQKEDFLKLSCHIDGTTNHLRDGILAALSETIEKKSAVLDRQAEYKKTSAISRAPKYLTVHFVRFFWKRQTQKKAKIMRKVTFPQELDIVEFCSDELKKALIPVRDKVREIRKDEEDIERARKRRKRNHEQDVGDIPGGSGLAPSKKDSKKDGKTDKAKEADDGTAGETFKTDAEIDAEKDAAVLAAKKELHAMIDPSLRDEGANQSGLYELRCVVTHQGGSADSGHYTAYVKKPAAVDPKTGKTGEEDGMWWWFNDDKVTEVKVDKIEGLAGGGESHSALILLYAAIPLPTADGTME</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFV7</accession>
    <name>A0A367LFV7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_0800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFV7"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI13298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="80" mass="9167" checksum="843E1CA28AAB0A7D" modified="2018-11-07" version="1" fragment="single">MDGCEGFIAESTADRDSIVLFIAHALKNDDDNQSCLRAERLSDAVKPRMSKWTMKIERINKHICALPNNRLASRFSFPWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFZ9</accession>
    <name>A0A367LFZ9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_1207</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFZ9"/>
    <dbReference type="STRING" id="1330021.A0A367LFZ9"/>
    <dbReference type="OrthoDB" id="10254877at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006089">
        <property type="entry name" value="Acyl-CoA_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF28">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00072">
        <property type="entry name" value="ACYL_COA_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="10">
        <location>
            <begin position="290"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="9">
        <location>
            <begin position="762"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="8">
        <location>
            <begin position="888"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="7">
        <location>
            <begin position="1000"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="713"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI13341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1187" mass="132105" checksum="B9C12DCFDD2D3059" modified="2018-11-07" version="1">MFRRASQGEGIEVSTWMDLLSGADGANKSQSHTKRSRRLSSACMTLTAATISFGPGSAGLLLKMAESSEFLSGGFIRIYTELQIEDEKVLGFGVERDRCSESQTGETETSYSLYAVEMGNCRGPPFIVRRRLDDVSMHRTRAEGLPLQAARAEGYPIHQLRRNILPPCLSHQSHPTAARKCPPVMLPALTARLASACRPAGLSSRFSRMSSSLFRQLQHTVNAAHTREYLGGTVGGDDDRPLLSVKQYVPLDNPDPQPGDVTIIGAHANGFSKVRSLRLLFCSELYEPLWDEVYQLLAHRGVRVRSVWIADMWNQGQSGVLNEKMLGNDPSWFDHARDLMSLINQKLDDIRHPIVGIGHSMGATQLSLLSLSHPRLLDALVLIDPVIQLGNVGIVPAVLSTRRRDVWPSMKAASEKFKKSEFYKSWDARVLERWTEYGLRPLPTELHPAQAEDDEGVTLTTTKHQELFTFLRPTYDRNSKVDMDPDQAAKMADYPFYRPEPAYVYKHLPNLRPSTLYVFGEKSDVSTPELREEKMAMTGTGVGGSGGVVEGRVQQITLNCGHLVPMEKVEECALAITDFLDAELARQRREAMDHQAQLAQLSRREQMAIDDRWARLVKPEEKLDDDEHFENILDIWREMRLVRWHATLDARIISKWQNDKDGGSLGPRLLLAPSGPSLVYLYMHACMSYEHAYVELCIYIHISYITRQERPRRWKRKKRTKQSSPSPPCMSMPPDAKLQLSEQIPWSEPAWHHTLSSPYYNESHRRLRDSIRRYIDAHVLPFSPGWEEAGCAPRAEAVRFSASGIPFQDVPDAYRPAHIPRLAGLPHDQLDAFHFLVAADETARVEGGVVIALAGASAIGVPPILHHASDEQKARWLPGLFSAETSFCLGVTEPLAGSDVAGLTTTAELASGQGGGRQHYVVNGAKKWISGAPWATHMTTAVRTGGGKGKGGISVLVIPLSLPGISMERIENSGQKAGGSCLIHLDDVRVPAANLVGRENEGFPILMTNFNKERFLLAVACNRKSRTCLAMALWYATRRETFGRPLLENQVIRRKIAEVAHRVEAHWAWLEQVAFHVQNGPLGWQGPDLAARIALLKVQGGQMLELAAREAQQVFGGAGYQKAGPGATVEQISRDLRMMVVGGGSEEVITDLAIRQELLMAKLIIILGRKVFSAGKDREERQSFEFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGS5</accession>
    <name>A0A367LGS5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Small acidic protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_5463</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGS5"/>
    <dbReference type="STRING" id="1330021.A0A367LGS5"/>
    <dbReference type="OrthoDB" id="10066125at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026714">
        <property type="entry name" value="SMAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028124">
        <property type="entry name" value="SMAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22175:SF0">
        <property type="entry name" value="SMALL ACIDIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22175">
        <property type="entry name" value="SMALL ACIDIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15477">
        <property type="entry name" value="SMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small acidic protein-like" evidence="4">
        <location>
            <begin position="505"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="52"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="127"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="161"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="225"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="291"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="322"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="354"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="376"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="410"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="436"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="479"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="529"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="553"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI13611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="580" mass="63481" checksum="E90FEA4AAA29BF0E" modified="2018-11-07" version="1">MHIVSSQDVIARASAKLTAKSICIRDDEDELDGCHVLCRQLKILSFDTRQPLSTDPEAKKLSRESKDGAKLSMEERKAKTAVNLAKKQERKRSRYLAKKQKLEKQAHKLLDQARRAGKIHEAIMRAHEEKQNEESGEKAENVKTDVPAYDLLIGDSNESSNGDDEAPTDEAVPEAPNESDVPASSAVEQDTTTEENVATEAAKKKKKRSKNKDEQDAMTGGSDSTGKRKRDEAADETKEEEEPIAKKDKKDKKGKKKEKEEETKKKDDEVEVDGVVQNGNDADADDDDKGENESKAKEDEVMTTTPKEDERQEGEGEGAGAGDKKVKGKKDIKDKKKKSKTKDDKDTVVTAKNEGGDEGDKTRQAKVDKKKKKSKTKDDKDYSVTAKDDVDEGNATDQAKAEKKKSKSKKDKDVVETTKDEGEGGEGNASDQVKADKKKSRSKKDKKSRFKEELGGEDDGSVDVPKVDDAGKTKKQKSKKEGKDKKDKKQREAANGQDSAAAERWNVGELTGGTSRQDKFLRLMGGGKKASSSSPAAATAKANSKDLSTASKAEAEIQRQFEAGMKMKAESGGQKRGLGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LH07</accession>
    <name>A0A367LH07_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_8157</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LH07"/>
    <dbReference type="STRING" id="1330021.A0A367LH07"/>
    <dbReference type="OrthoDB" id="10251371at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15845">
        <property type="entry name" value="SNARE_syntaxin16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.70:FF:000021">
        <property type="entry name" value="SNARE complex subunit (Tlg2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF83">
        <property type="entry name" value="SYNTAXIN-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="12">
        <location>
            <begin position="249"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="197"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI13724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="346" mass="39051" checksum="75613007120DE8AF" modified="2018-11-07" version="1">MWRDRTNLYLSYRQSYAHHPTQRKRAGAGGASGAFSDVYPGAGSGYGDEDRRRLLSAGGFDDDGDAVIEMDLLPPRWADVSDEVTDLLADIAKKSQRLEKLHQKHVLPRFEDDAAKKLEEAQIEKLTQEITKGFHECHRCVQRVEQMVREARESGVLSGAEDTMARNIQISLATRVQETSAEFRKKQSAYLKKLRDMGGLGTFTPTERSPTPQPGSHLRPSLQESDADRVFSQSTLLAASEQKMLHSNDAVIAQREREIEDIAQGIIELSDLFQDLQTMVIDQGTMLDRIDYNVERMNEDVKGADKELKIASGYQRRTTKRKIILLLMLLVAGLFILLLIKPKKHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LH32</accession>
    <name>A0A367LH32_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_8210</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LH32"/>
    <dbReference type="STRING" id="1330021.A0A367LH32"/>
    <dbReference type="OrthoDB" id="6247875at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000041">
        <property type="entry name" value="HMG box family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF161">
        <property type="entry name" value="SEX-DETERMINING REGION Y PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63825">
        <property type="entry name" value="YWTD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="128"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="4">
        <location>
            <begin position="128"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="191"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI13697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="219" mass="25196" checksum="9F62F29C8F513258" modified="2018-11-07" version="1">MSAPSNANNPGGLVTTANNRHLWFSLRDQIHPFAQVLSIDGHLFNTMDNNAKQYIAMKFMNHVQENVIYVHDGNGPNRIYLGAPRHFVTGGGMVIDPNGRDLYWIRRGQSNVVTATMMAPPQPKNVKIPRPPNAYILYRKERHQLVKRANPGITNNEISQLLGKAWNMETPAIRAKYKQMSDEIKEALMKKHPDYVYRPRRPGERRRRRRQEDGEDDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LH44</accession>
    <name>A0A367LH44_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_8080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LH44"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI13756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="79" mass="9171" checksum="2BE5E0C3BDDC5106" modified="2018-11-07" version="1">MGKATKIGTLRNRTDRRIQAFVQLSYNRGYAEGMSSMLYDVKHLSYYLSDRDFRRQGGKEGGWQQIKINRLSIGPCHLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHY4</accession>
    <name>A0A367LHY4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_8033</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI14043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHY4"/>
    <dbReference type="OrthoDB" id="10428481at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16148:SF23">
        <property type="entry name" value="B BOX-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16148">
        <property type="entry name" value="NF-KAPPA-B-REPRESSING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016885715" evidence="2">
        <location>
            <begin position="19"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="285"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="463"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI14043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="538" mass="58273" checksum="2AAEEE873362627E" modified="2018-11-07" version="1">MNKTAILQILSFLGRTSASHISPQEIINQARQYCGPYWNLETLWQRPPEACHAARFSHPTNKTCEYDQQAYGQLLDQECTLIGICSADFDKLGRDSTQETRSSIGFCLTNAFRRLQDVSCCQPPPLQGDPRDFDGSRNEPAESAAQALSKMSAFIQTICGDTSWTRPRRGCPVADSGFMSHVPACPADKAATYRGELKDACETWFDQRRKSIQWDQRSFSRIFLDVITFKSVPNEIAAWFRIKKAACCKSVVDDEDQKSKESPSAASPASHNLQQQRQKQHSVVNNNNNNNHNNNNHNNNNNNNNHNNNHNNNNNNNKGRSFQKIEWECSCHETGHERDARERRKRIGAGAGGAGAIIVPGMGGGGGGGGGEEVGAIIELLGEEVVIVDAIQPPVSGAAAGSFFGVLAKTAGGTYIWFHGIAAAFGTVQMAWKTADGIWLMVPTTASATASVQDQDEDQADGSSSIAASSDSSSPSSPSLSPSPSPSPIPSPVPSSGFGILLEGIEVEAEPKWNVSVTRPPTYDVHPWAMKIPEGRSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHZ6</accession>
    <name>A0A367LHZ6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI14048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHZ6"/>
    <dbReference type="OrthoDB" id="2349272at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="167" mass="18358" checksum="C6D237D8C52A3FAB" modified="2018-11-07" version="1">MPLRPPGKPPADGVVPQPRRQVQAGSGLSDKPHAPRNSRPEIPAQHLARTPGTRNGKHAALPLQHRCTTALDCILKRDDKSFDTPAWFLQKMCDKPLVRHQLREGGIAGCRAYLRDCVGVDPADAQREALNEMAYHVFGVTQATACVPLDDDRIQQSTDDSKKPPKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LI43</accession>
    <name>A0A367LI43_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH TFE/IIEalpha-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_8140</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LI43"/>
    <dbReference type="STRING" id="1330021.A0A367LI43"/>
    <dbReference type="OrthoDB" id="361102at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039997">
        <property type="entry name" value="TFE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017919">
        <property type="entry name" value="TFIIE/TFIIEa_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002853">
        <property type="entry name" value="TFIIE_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024550">
        <property type="entry name" value="TFIIEa/SarR/Rpc3_HTH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097:SF7">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02002">
        <property type="entry name" value="TFIIE_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00531">
        <property type="entry name" value="TFIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51344">
        <property type="entry name" value="HTH_TFE_IIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH TFE/IIEalpha-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="237"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="329"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="367"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="248"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="335"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="380"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="413"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI13922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="429" mass="47292" checksum="4CDEA108191A6808" modified="2018-11-07" version="1">MDLAVMLIKSVMRAFYPTRDILVVDALMLHEALRDDDLAYLMAINTKDLHKICGKLREDRFLDVHTRQEMRPGNPRPSNRTWYYINYRHTIDAIKWRVYTIDKDIQGNTVPANEKKEYFCTVCKAEWTTMDVIDNSGPDGFLCHRCNHTLTFEVDRNSGGHEQSTRLNNQLKFISELLPKIDAVHIPECDFDRALAKARPVVRDVTHQRAATIPVDMGTNRPMAVKGLMNTGPQSIAINISASDGPSEAEKEAERSRKERIAKQNALPSWMSNSTVTGESFSAAADISTVAVAKVEARHVGFNKDVDNTTSAEIDDIFEKLKAEQAALSKSAGAENEDLGSEEDEGEFEDVPAAAAAAAAAAAAAASKPILSMPTAGPDSRNTVTYDDAHASSSRANKRVRLGIEDAAGGIGEQDDDYDDEDELEFEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIG3</accession>
    <name>A0A367LIG3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIG3"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="91" mass="9691" checksum="57BE627839F59C47" modified="2018-11-07" version="1">MLIRRLIILLKKARLAYLILKRPPPTLLCRSYLSSVTYGGLGPAVAGPASPASYVVVPFLPLLCDVRRPRAGRSRPGVTVSGAPAKLLPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIH5</accession>
    <name>A0A367LIH5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">JmjC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_5992</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LIH5"/>
    <dbReference type="OrthoDB" id="298344at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.650">
        <property type="entry name" value="Cupin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017956">
        <property type="entry name" value="AT_hook_DNA-bd_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003347">
        <property type="entry name" value="JmjC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018866">
        <property type="entry name" value="Znf-4CXXC_R1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02373">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10497">
        <property type="entry name" value="zf-4CXXC_R1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00384">
        <property type="entry name" value="AT_hook"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00558">
        <property type="entry name" value="JmjC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51184">
        <property type="entry name" value="JMJC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="JmjC" evidence="6">
        <location>
            <begin position="171"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="164"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="549"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="696"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="906"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1053"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1304"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="696"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1053"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1098"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1149"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1338"/>
            <end position="1358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI14243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1375" mass="154832" checksum="330C5BCC7C645B52" modified="2018-11-07" version="1">MPTSLHPQAKFDPLPPDIDVRALVDRTPNFRWVQRVSRSQIRNLGPQEFERLVQIHVIAGGKPLVIDGWDAVLPKWLFNVDWLEKTYDKKRENVRDIPTATDIPMTTGHYLRSMRQLANQWTPHTYRDDRRQRLYLKDIDCPLEWRDALQKVIHPGLFYLNENVNTPGTGGQSQEDDDFRSGASAAPSGDLMSSLPETMRAENLMCYIGHEGTYTPAHREMCASLGQNIMVETSGDNEGDKPGSSIWFMTESKDREVVREYFLSMLGHDIEIERHFAQVNAWKKAPFDVYIVEQRAGDFILVPPLAAHQVWNRGTRTMKVAWNRTTVETLDLALHEALPKARLVCRDEQYKNKAIVYFTLQKYFNELQQLEKNAETTRTSLVGIGHEIARKSSRARQLAVDFKRLFALFTEILMDEAFAYKEKEIDYLPFDSCVTCSYCRSNIFNRFLTCKNCIRTLDTGDEDAYDVCMECYAMGRSCACLSRLKWCEQWSWPGLVERFETWRATVISNDGYVDMQASPQSFEVARLKSGKKSVAQICQEALRRRPWKDITKQEDPVKSPSDSDPVEGDERSKKKPKRKKKKGEVRRCHVCCHKDYSYRVHECSNANCTEAYCYGVLYRAFDLMPQRVLEDEYWQCPKCLGICSCGSCRRSGNTNAYTPKNTLLGHDTRPIADDRSVEALVDFRVHNLSWLKAVGEESRSKDSRRMQRLREQANNAKAQDRTHQAQQAIPHDAGAVASAGINAPEKLKEASHGEHCTALESNSSALAGQDGCEKAGFVADETTPFLDMASPVEMNGDTPNDPTYPDPSVFMLQRIGMGYYEQDDTPDKILFDPYQAPSADAVGLPEASVPDFVKKSIRAAKRKARRENEDPDFVVGRSYHKRSRFAQRSDMLDSMDPALFEVRGGQEADDGAPVDHFDAQSRQPSETLQRMSEASLQRRHVAPRFDANEPALRHAKPLASYVELEDADMEEFEEVDQGYLNIPKTETHATVVHENVVDDTTKEDFSMPDCPASRGESAIAQPAGEDATLIIVRKRRGRPSRHMSLTTAHETQLSTPVNSATSVEKTVGKRVSGRPRKSMNLDASVHGEEETQALTETATERMMKDRPQAQHPRETAARPKNYQLPKAVSLRPTRGRRVTRIGAATADEELSHEGESDPDPLSKADVQRGPPPSHDTPLQPKRGRGRPRKSDIRRSGTPMGEEDELASPTFMSLAERMALRGKRFKIRRKLKRGLSGLTSETSTHQEDGEAIADAPASGALLNIEKAQSPIPIGEVDRSPSEIVSDARNGDASFAAESELKREPTVVRLADVESDEDAGSQVSSSSTDEDDIPLNFGTHRGRGSFRGRRGYRGRARARGVRTLSSPSRHLRRGTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIR1</accession>
    <name>A0A367LIR1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_6041</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIR1"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="60" mass="6948" checksum="0DD7966FA6BEC254" modified="2018-11-07" version="1" fragment="single">SNEEDIRRIAAIGYKEAIKFFPEEKRPTSPERIYKKSFNKANKKTIAPNPVLTKVDDLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJD9</accession>
    <name>A0A367LJD9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJD9"/>
    <dbReference type="OrthoDB" id="6079484at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="159" mass="18566" checksum="F20EE5F64BB04AA7" modified="2018-11-07" version="1">MPRRKSKKSTALEQGQQEQGQQQQEQQQQQQQQQEQQQQQQQQQQSAVLQQQRELAQRQHELEIQQLLQQQLEKKPLHQRPPYYYHQYRAAYVAATTDAAFTPPPPAADPAPFTPFVAGPLGGGFYKYRCKYWFSHGCGNWVLVNREPCALCMANGRYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJL7</accession>
    <name>A0A367LJL7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Only prolin and serin are matching in the corresponding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJL7"/>
    <dbReference type="OrthoDB" id="3882058at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="282"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="328"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="555" mass="60504" checksum="F14F9DCE8A00D9D2" modified="2018-11-07" version="1">MSSLKLKPLLLPQLVEERRKLDGQQCPPASPDVVVEISHVLSAANSSESDAESPVTPVVSPCGLLQQNMSSSPPELPSPETPSSPTVQLFDKRLLPDVKEDPMERFEEDASSFSSASSDHNDLYSCLCDTPCQHCSSSEGLSPDDFDLDYDMGCFSDGDSAADSQYKKRAVDSSSPLAGLTSRIGSRLPTIKRWRSSRRANTVSSPLTDLSLENVFSRGPSSRSSSLSASNQQTTPERLSEMPSCSTVSCYDSSDNLTGSTHVDMTPEEHSSLERNRSMATTPLLPPLLTDPLGKPPQESPLLAAPPPAPPAVAPAPVGLPPPPPLSSRPSLTSLRQVSSSSTAAELPLPLPAIMQEHDDWSDRLGHANFTITPIPYELETLSAETVGRFRDDWDAARVNYTKHLVRTGEHYGQTSKTYALTEAKWAETERRWKGFYDDLIRQSSRPPPDSGNPSRSHSRGRGRGRSSSSVPVMGRLHSSDDVLADLDWRRMDDCLPSAVPRMLESPDAQGKFPCRGDEDIVGPMQRAAVMARARSEDAKGHFWRSIADKVGFRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJR2</accession>
    <name>A0A367LJR2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome assembly factor mrt4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_6416</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 6">Associates with the pre-60S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJR2"/>
    <dbReference type="STRING" id="1330021.A0A367LJR2"/>
    <dbReference type="OrthoDB" id="10262308at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05796">
        <property type="entry name" value="Ribosomal_P0_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000003">
        <property type="entry name" value="Ribosome assembly factor mrt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033867">
        <property type="entry name" value="Mrt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051742">
        <property type="entry name" value="Ribosome_Assembly_uL10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841:SF1">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 MRTO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="7">
        <location>
            <begin position="79"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI14639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="201" mass="22012" checksum="CDA5F5B8904F368C" modified="2018-11-07" version="1">MRNSHLKTVRRELREDSRLFFGKTKLTAKALGQTAEEELAPGIHRLTPFLTGSVGLLLTNRPPHAVVDFFAGLTKVDFARAGAVAPRSFTIPPGVVYSTAGEVPAENDVPLEHTIEPELRKLGVPTRMRKGKVVLGDDDGEGDGYLICKEGDVLDSRQTRLLKLFSICMSEFRVKVVAYWSAASGEVTEIKASSMEGIEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJT0</accession>
    <name>A0A367LJT0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">S-formylglutathione hydrolase</fullName>
            <ecNumber evidence="2 7">3.1.2.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_6661</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Serine hydrolase involved in the detoxification of formaldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>S-formylglutathione + H2O = formate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14961"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:57688"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="EC" id="3.1.2.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the esterase D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.12" evidence="2 7"/>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJT0"/>
    <dbReference type="STRING" id="1330021.A0A367LJT0"/>
    <dbReference type="OrthoDB" id="420518at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018738">
        <property type="term" value="F:S-formylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046294">
        <property type="term" value="P:formaldehyde catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000002">
        <property type="entry name" value="S-formylglutathione hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000801">
        <property type="entry name" value="Esterase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014186">
        <property type="entry name" value="S-formylglutathione_hydrol"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02821">
        <property type="entry name" value="fghA_ester_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10061:SF0">
        <property type="entry name" value="S-FORMYLGLUTATHIONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00756">
        <property type="entry name" value="Esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0719">Serine esterase</keyword>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="151"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR614186-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI14522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="282" mass="30771" checksum="3E5FE9CF47DC850E" modified="2018-11-07" version="1">MAFTIDASVPTCGGILLKLSHQSTSTSTKMSLNLFLPPAATESHPAPLLIYLAGLTCTPDNGAEKAFLQSHASPLGLALLFPDTSPRGSEIAGEKDDYDFGEAASFYLDATAHPWSSTYKMETYLTRELPSLLFDSFPLLSRTHVSIAGHSMGGHGALTLFLRHPTLYRSVSAWAPIANPSQCPWGEKAFRGYLGQDRESWKEHDATELVKTWNKARPISCLIDVGTGDNFYKQGQLLPENFEKAVKEAGIDGVKGYDHSYYFVSSFGEDHIKHAAKALGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJT2</accession>
    <name>A0A367LJT2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_6951</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJT2"/>
    <dbReference type="STRING" id="1330021.A0A367LJT2"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032889">
        <property type="term" value="P:regulation of vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052239">
        <property type="entry name" value="Ser/Thr-specific_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45998">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45998:SF2">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="58"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="194"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="394"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="202"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="231"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="258"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="410"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI14659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="469" mass="51493" checksum="759A1CDD663B662C" modified="2018-11-07" version="1">MAQLMLDLLSSVGNCLNCFPGSPTLRINGRSFKMLRLLGEACIVIVYQTLSCYRLDNLTLISFHLQGGFSYVYLVEDTTTHQLLALKKIRCPFGAESVEQAMREVEAYRLFAHVPTIISAVDHVVATERGSSDESSKTVYILLPYYRRGNLQDMINSNLVNRSAFAERHLMMLFLGVCKALAAMHRYRPPSAVERMRVVGDGDGDGDEDEDDDDEERNRPDDLQHRPLMAPHPFSSSPSSSIHQHHQHQPPSPPSPSPTRKQQQQQQQQPPSKQPRAYAHRDIKPGNIMINDQGTTPILMDLGSVAPSPIQVTSQSIALQLQDTAAEHSTMPYRAPELFDVRPGSVVDSKSDIWSMGCTLFACLVGKSPFEMRSDETGGSLSLCVLGADWRFPDESPGGAKRPPQKQTNSADDSSGAAAAAAASISEPVRDIVRRCLKAEPAERPDITELIALVEAVIEGLPDDSSSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-09-13" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJZ5</accession>
    <name>A0A367LJZ5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6683</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJZ5"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016935831" description="Reverse transcriptase RNase H-like domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="119" mass="13459" checksum="AA3525CF0FBD0837" modified="2018-11-07" version="1">MLAISSALLALLPRSLDLCNPKDKVAAFRISYKILLDILDMLVNEGDLTTSSKAILSSIRHSRLSLLISLKRYCLRHISGKKNLIANALSRKLTIEIDWIKREKDSDSEDFIDLYLNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="5" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKG0</accession>
    <name>A0A367LKG0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_6991</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKG0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="68" mass="7444" checksum="133C3E6B7F961052" modified="2018-11-07" version="1" fragment="single">AIGGRRRSELIRCDLRKTYSAEARSRHIPLPHGDSGLPGWSWLSAGGHQTMRLVMTTTATLSAPWLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKS0</accession>
    <name>A0A367LKS0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_6867</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKS0"/>
    <dbReference type="STRING" id="1330021.A0A367LKS0"/>
    <dbReference type="OrthoDB" id="644067at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47416:SF8">
        <property type="entry name" value="BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTOR E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47416">
        <property type="entry name" value="BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTOR F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="9">
        <location>
            <begin position="253"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="175"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="251"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="187"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI15023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="615" mass="67468" checksum="28A288B2D9767E23" modified="2018-11-07" version="1">MVLQFPAQPFYRAANLTVHTSHAQQKYGPEDEDKSVLEDGIIDPGAVDSGLELSPPMVSSRRESFAVGSALFSPKSEGWHSVDMQSLPSNNPFVDQASTGNDNSPFTRLDNTQQQQVFGAQQQQQTGAWLVGHGHDSGSGPGSGAATPFPAFDHVEYDSGVSIFHRQMQGQTSFGASNIFGPLDPSMPTSPQKDWSVNKQRRAGSPPIRSHNDMRRGDGIRKKNARFEIPAERNLNNIDQLIAQSTDDQEVKELKQQKRLLRNRQAALDSRQRKKQHTERLEDEKKQFTLLVTEMEEEINSLKAKMDQLLCEKQTYSNYVESLRAEKDEMIRAHTIETGQLRKRLGVVTEHVQRLQGGSMGPTISGHSFADEYDGMDDVAMTGGWDHAGLFDSYPPVEPPSVKQQQQQQHQQNMAVVPVNKKMESDGDKSPVSQGGLLFMLFLVGAFVLSNRSTPAIPQVSEDVRAASATLLDNVLKDAGVSSQPHASGVGWAHPAPSGMSVGPSMLDELGDSLTQPTEEQTHDQIFSLTAAEYSGVSDQDYARHSPTQPAGLGRRNLADALASMRAASKQTGAAEVYTRSLLWDQIPSEVVRNFAKMVAECSSAQNEQPCNDTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKZ0</accession>
    <name>A0A367LKZ0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKZ0"/>
    <dbReference type="STRING" id="1330021.A0A367LKZ0"/>
    <dbReference type="OrthoDB" id="5385910at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="240" mass="24150" checksum="747099F607ED7BB7" modified="2018-11-07" version="1">MAPIPVYSASPINTATETPTPTDKNQDKTKTTATAGPGLEGRQHAQPGAAPTLPTATGVPQPAPAAAIPSRVLPASPPAPQPGAAPPPPGLPPPPKAGEAAAAAAVAVAAKQNSQAPAQTSTPPQMPPQLSYQAPTVAQPFQGRSSTTADPHGYMGGRGPYPAPVHGTGVNSSSAGYINQASGYPHQQSLSGPQNSITTSSAELDDQSPGMWDTARKWASAAGESLAAAESEVWKRINKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLN0</accession>
    <name>A0A367LLN0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phosphoglucomutase</fullName>
            <ecNumber evidence="4">5.4.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Glucose phosphomutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">L249_6738</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Catalyzes the reversible isomerization of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate. The mechanism proceeds via the intermediate compound alpha-D-glucose 1,6-bisphosphate. Key enzyme in hexose metabolism. The reverse reaction is an essential step for biosynthesis because glucose 1-phosphate is the starting point for the synthesis of UDP-glucose, which acts as a precursor for the synthesis of oligosaccharides and trehalose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>O-phospho-L-seryl-[protein] + alpha-D-glucose 1-phosphate = alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:68748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:58392"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>alpha-D-glucose 1,6-bisphosphate + L-seryl-[protein] = O-phospho-L-seryl-[protein] + alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:68752"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58392"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23536"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="5.4.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="4"/>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLN0"/>
    <dbReference type="STRING" id="1330021.A0A367LLN0"/>
    <dbReference type="OrthoDB" id="2291at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06135">
        <property type="entry name" value="Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03085">
        <property type="entry name" value="PGM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000002">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000004">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000005">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000006">
        <property type="entry name" value="Phosphoglucomutase PgmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022894">
        <property type="entry name" value="Oligoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045244">
        <property type="entry name" value="PGM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003765">
        <property type="entry name" value="PRK05359.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005737">
        <property type="entry name" value="PRK07564.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573:SF2">
        <property type="entry name" value="PHOSPHOGLUCOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573">
        <property type="entry name" value="PHOSPHOHEXOMUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24947">
        <property type="entry name" value="PGM1_C_vert_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0313">Glucose metabolism</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="19">
        <location>
            <begin position="6"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00039995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00041398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00056382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RCI15345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="738" mass="79799" checksum="0295B68253654C2B" modified="2018-11-07" version="1">MADEEPLVWIDCEMTGLDPDTDEILEIYCLVTTGQLEPLDGGNGDDTGFHAIVHWPLSRLDQMDDWCTKTHRASGLTAAVTASTTTPAQAAAGLLAYITKRVPEPGRALLAGNSVHADRAFLRREPYAAVVGHLHYRLLDVSAIKEAARRWCPAGLLEGAPRKRLRHLARDDVLESIAEARFYRDAIFGTVSLEPFQDQKPGTSGLRKKVSVFQQPNYSESFIASIFLSIPEGVNGSFLVIGGDGRFWNPQVIQVIAKMAAAYGVKKLLIGQHGILSTPAASHVIRLRRATGGILLTASHNPGGPKNDFGIKYNLANGGPAPESVTDKIYQTSKTLTSYKLASIPDIDISALGSKTYGSLEVDVIDSTADYVAMLKDIFDFPTIKTFFSNHPDFRVLFDGLHGVTGPYGKAIFETELGLSNATQNCIPSPDFSGGHPDPNLTYARSLVDAVDAGKIPFGAASDGDGDRNMIYGANAFVSPGDSLAIIAHHARLIPYFRRNGVHGLARSMPTSGAVDLVAKAQGLACYEVPTGWKFFCALFDANKLSICGEESFGTGSDHIREKDGLWAIVAWLNIIAALGVEKPAVVPSIKQIQADFWKQYGRTFFTRYDYEDVSSDGASKVVGELKKLVADPGFVGSKIGDRTVTRAGNFSYTDLDGSVASNQGLYACFSSGSRIVVRLSGTGSSGATIRLYIEQHSSDPATYDMDAQQFLRPEISFATGLLKFKEHLGRDEPDVRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLR5</accession>
    <name>A0A367LLR5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_7038</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase gamma chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLR5"/>
    <dbReference type="STRING" id="1330021.A0A367LLR5"/>
    <dbReference type="OrthoDB" id="239812at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12151">
        <property type="entry name" value="F1-ATPase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.80:FF:000001">
        <property type="entry name" value="ATP synthase gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1380.10:FF:000003">
        <property type="entry name" value="ATP synthase subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.80">
        <property type="entry name" value="ATP synthase, gamma subunit, helix hairpin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035968">
        <property type="entry name" value="ATP_synth_F1_ATPase_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000131">
        <property type="entry name" value="ATP_synth_F1_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023632">
        <property type="entry name" value="ATP_synth_F1_gsu_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01146">
        <property type="entry name" value="ATPsyn_F1gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693">
        <property type="entry name" value="ATP SYNTHASE GAMMA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11693:SF22">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT GAMMA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00231">
        <property type="entry name" value="ATP-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039089">
        <property type="entry name" value="ATP_synthase_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00126">
        <property type="entry name" value="ATPASEGAMMA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52943">
        <property type="entry name" value="ATP synthase (F1-ATPase), gamma subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00153">
        <property type="entry name" value="ATPASE_GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="9 11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="4 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI15374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="307" mass="33273" checksum="34BFD6CC355E8ECC" modified="2018-11-07" version="1">MLSRAVRPALRGAAPTRAASAVTAAAAAGAPAAGYATLREIEGRLKSIRNIEKITNTMKIVASTKLNRAQRTMLESRKYGQTSNEVFEAAETAPLKDEGSDKKLVIVCSSDKGLCGGIHSGMSRKIRAMSASEPPFDLVIIGEKCKSQLQRTNANNIRLSFSGVGKDVPTFADAQSIADQIVMLPTDYSEVQIMYNKFLNAQSYEPTFIEAYSEEAIIQSPNIAAFEIEDDVLSNLREYSLANSLYWALAEGHACEQSARRNAMDNASKNAGEMIGKYQILYNRTRQAVITGELVEIITGATASADM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LM34</accession>
    <name>A0A367LM34_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_3363</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LM34"/>
    <dbReference type="STRING" id="1330021.A0A367LM34"/>
    <dbReference type="OrthoDB" id="671439at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01838">
        <property type="entry name" value="Isoamyl_acetate_hydrolase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045136">
        <property type="entry name" value="Iah1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209:SF19">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="2">
        <location>
            <begin position="42"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="206"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI15460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="318" mass="34534" checksum="A24EA0654A23FFBD" modified="2018-11-07" version="1">MQAVLVGDTSDRASNPTTITKNTIKKKGGGRDMAASYPQVVLFGDSLLQHAVDIQLGFSFQAALQSHCNRRLDVVNRGLSGYNTSNALRFLEDIFPPMGEGTPEMKYIIVLFGANDAVLPLPTTSQHVPIDEYTKNLEAIIHHPRIAAHKPKVLLVTPPPINEMKLAELDLAAGHPSVTRNFDTTAAYSERARTVARRAWEMKKKKMMMKKKGGGGGGGGQQHGGEEEEAVAVVLIDLWKALMDRAIAMAPQDQRPGGPWVGSRENGKAGGLESLLPDGLHLGGEGYRILFDLVRPHVGQGWEAVEGDGFVFPGWKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LML9</accession>
    <name>A0A367LML9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_3448</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10256089at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031991">
        <property type="term" value="P:regulation of actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032955">
        <property type="term" value="P:regulation of division septum assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07589">
        <property type="entry name" value="BAR_DNMBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
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        <property type="entry name" value="Dynamin-Rho_GEF"/>
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        <property type="entry name" value="MFS_trans_sf"/>
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    <dbReference type="PANTHER" id="PTHR22834">
        <property type="entry name" value="NUCLEAR FUSION PROTEIN FUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22834:SF20">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
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        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1801"/>
            <end position="1821"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1833"/>
            <end position="1851"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1857"/>
            <end position="1881"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1917"/>
            <end position="1935"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1947"/>
            <end position="1969"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1996"/>
            <end position="2016"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="2049"/>
            <end position="2072"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="2102"/>
            <end position="2122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="2128"/>
            <end position="2151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="2213"/>
            <end position="2240"/>
        </location>
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    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="2265"/>
            <end position="2284"/>
        </location>
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            <begin position="1115"/>
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            <begin position="21"/>
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    </feature>
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        <location>
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        <location>
            <begin position="2176"/>
            <end position="2204"/>
        </location>
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        <location>
            <begin position="21"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
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            <begin position="118"/>
            <end position="127"/>
        </location>
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        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
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            <begin position="169"/>
            <end position="182"/>
        </location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="2">
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            <begin position="190"/>
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            <begin position="447"/>
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            <begin position="565"/>
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    </feature>
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        <location>
            <begin position="881"/>
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        <location>
            <begin position="908"/>
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            <begin position="1201"/>
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            <begin position="1679"/>
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        <location>
            <begin position="2179"/>
            <end position="2193"/>
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    </feature>
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            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI15686.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="2290" mass="248267" checksum="07178ED99EC52A08" modified="2018-11-07" version="1">MSPDLDGAACIDLDRDSRHLLHQDSDESNHDVSDSTLHHPHHVASPDDFYSSQQRALKLETHMASSSPAYHSSLIPLAANMKSPADGGPRAAARSASNPLDGKSSGPTLTKAPTGKPSVKDLKKRFDQNGSASPSLPRAPLRPGAPPPIRTTRPLAANGTPKLRAGSLLDSTTTTPFASDSPSAARVQRQKSIALTSSSQSFASRIGRPRNSINGKPTTSKSMTQLQHRTLPGQPPSPPAVTSRSTALLFGEIGPDHCGASIAGFGVQHSRPRKASDSNVPAPRRRFSGPDSDSSSPSSCYRQVDALQGASLVPPGVRSRFHARSRSDASAPLTCVGFSCKPLPRTPSTAGLGHSSSASRLPVSVRLLTSPVESTSPASTRSNSPTALKCSLANGRISAIGAIATPSTAHASTRTRTPTQVRKPSPHALVTPDSLARIHSAAPPTKSLPLRSSRPRLPVSVAGSRKQEMDAQPSRLGPFPNGPSRTNEETARRRKISIGPIDFEQRREHIRLAYSKSIRESEALEARQIAAAEKKRRDLEAAAAAKAKSRVDADVAPRALSEVPDAYKEKTSERRSRQTAAQPAEFFEAQLSADAAAQPLPQTLADSLTRPPLAVCTTLEPDHVVATPQPADEVDSPTLGVPGSFPVFSSPSETGNLPLSAVSGVSDTTEFDVDPQTNPPIQGQSPLNIHITIAEPSSPQHATSTQAQAAYQYPFDEESDTSEQVSQNARALQDAERPDEAQDATFQPEANDGVESKPVSLEKTLSAHQTLGAVVSVLPATEEETEEVESSATIPFPRLELLHDEHDLSDCESDLEVASRGDCYARQGDDDVTDACTEETDEHEDARLGQTNFGPDEPPSERASTCTSSDAGAVDNGEDSVVQSQPRDTANPSGLVVPPRLLQDDRLSQQSTWTDFSIDSTDPSDPTKSLAMHSRPDSPSFGHVTIFESNTRGRDSRTSLADTNHTPSTRGLDDSKTSSSSSSSAHATRSRLPEVDTGDGFFVPNLSSVASVSLSFLPPPEHEPSPIPNSVSGSALDSRTSSIFYDQSYYGSTVVSSEKEIDECASPLQTPQSLDMALPTTEAPDVRFSNGSMTDGDTKPAVQESDSKERHRLVQRRNVIKELIDTEAVFVRDMNIVEEIYKGTAEACPELDSKTVKLIFRNSDEIIHFHTQFLRELKAAVASVYVPVGGRGSLARGDSQASERGHGDNPQDSRDRATCLGPVFQSNVESMRLAHEGFLRNSDHAAKRLIQIQQDATVKVWLNECNEVAKDLTAAWDLDSLLIKPMQRITKYPNLIVTLLQHTPSDHPDREALLAAKDSLETAIIEINRTKKNFELVGQIVGRKRKESDVKAGFARAFGKRVDKLQASTNRPREDQEYVKLNEKFGDDYLRLQVVLRDVEYYTRQVAAYVHEFLQYLSSIELVMRFQPGNYPELESKWVQFNISVRDLEKVALEEHLAQVRKHVIEPFELVIKAYGNPSLAMKKRQKRRLDYERMEQLKRSGKTADPKLRELVEQYEALNDTLKKELPVLSALTEKVGNICLRNFVNIQANWYVIWKEKMKTVVGDCGEMPDLKEVVSTFQRDHPFVRDQLSGIGMLNPASRGRLSHSASANLEDSAVRARGRVLSINGDAAPMLPPPDFGERRSGSLTMSPSAGSPGLGGGMPHQYYYKDYYSGIHTQQASPRSPDMVSSSRTGATSTRPSTSRSIDSTGLPPRRSLEVLWLAASLFEFNISTTKHEAGYPYLTYQAGEIFDVVAEKGELWLAKNQDDATNRSNNNLTNDKKDCTPYLLKLGLSKSNTSLIWIAGPLSGLVVQPIIGVVADENSSRWGRRRPLMVVGAVVVATGLLVLGFTREIVAWASGGLGLTIGLAVVTIYVVDFALNVVQSCARSLVVDTLPLEQQQTGAAWWSRMAAIGHVIGYAAGSVDLVSLLGTALGDAQFQQLTVMAAWAMLASTALTCWAVTEPVLVLPAGARRKSIADVLHQVFRTLRRLSPRIQAICWAQFWAWIGWFPFLFYSTTWVGETYFRYDAPAEETQADDGDRVGDMGRIGSISLFIYSFITFVGAFVLPILIRSPEDDRFTPRPSPAVARLLGAVGDRRPDLVTAWMCGHVVFAASMVFAPLATSFRFATVLMCLCALPWTMATWAPPALLGVEVNKMSGSAYRPLPDDMELRNVSGARDYDNHDDGGDDNGRLETAPAAAGGKSSTAELSGIYLGILNVYTTMPQFVGAFIASIVFAVLEPGGSSSSSKPNVEDGSGRRRGPSAISVCLFIGACSAVVAAFATRKLKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMW9</accession>
    <name>A0A367LMW9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF4048 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_2053</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="4097086at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
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        <location>
            <begin position="97"/>
            <end position="163"/>
        </location>
    </feature>
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        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
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            <begin position="252"/>
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        </location>
    </feature>
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        <location>
            <begin position="403"/>
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        </location>
    </feature>
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        <location>
            <begin position="488"/>
            <end position="536"/>
        </location>
    </feature>
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        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
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        <location>
            <begin position="296"/>
            <end position="308"/>
        </location>
    </feature>
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        <location>
            <begin position="432"/>
            <end position="441"/>
        </location>
    </feature>
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        <location>
            <begin position="488"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="518"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI15759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="585" mass="63435" checksum="B89EDC2ADD20334B" modified="2018-11-07" version="1">MTAFLLRLCFINKLSHSLPDDYRHFTQAHYKTLAARAARQRLRRAIRASSTRSLHTRRRRHGSQSFQSPLRIRGLIQHSPGPSSSAITTAVGAIEPSPSAIMNSSSHDTHCSSTDQCQPESAPDTPQACHRKQQPADDATSKTDGTARLSPTEPGRCLHRSRPVSVASRAFNRLSLTIPIAPPTSGPSRPTPASGAPPPIPPAAVETPKLPLSSDANDFIIAVAAQERRVLELREELARAEAELALLKSRWSEEPRATKGPAQAPDMPGSATSDMADEVSLASRRSAELDRRKFLLQSQSVTHDTPQGNRRKVIRGGHARTLSLLSPSRLSSEISLPGNNVLGATDPRPVQAAAHPAQLKRASWQPRSVQSSPTVPQIVEDFKLGLRAFVDDLRQITVGDEPVRVTPTSRGPALASRRGSAGGPERLRSGLASVSQTNTPSPAMASPMPDNRILAAARIERPKPVKSKPFSWTPLGFDSMDDSDWSNWESPSVSKTTRWSGSTVNSGGGSEEIGSIPEVREDGLSPEKSRAGSKVRLEEMLPDMVNRVSSNNFKRRTSGWMDEWEKSLVVPDPDDQENQGPATTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LN39</accession>
    <name>A0A367LN39_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme E2C-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_3524</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LN39"/>
    <dbReference type="STRING" id="1330021.A0A367LN39"/>
    <dbReference type="OrthoDB" id="66510at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051865">
        <property type="term" value="P:protein autoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019193">
        <property type="entry name" value="UBQ-conj_enz_E2-bd_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31531:SF2">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE E3D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31531">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE E3D FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09814">
        <property type="entry name" value="HECT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI15662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="403" mass="43620" checksum="A50162B8C348E81D" modified="2018-11-07" version="1">MLQVVNEAPGPEPAMAIYAELLPNIQQVSVAAALSSPSDASTSAEVVDAGRRIRIRHRGHALAVELPAAVAASTALPLPRTSCSYLTWRLSAAALDARALPSTPENQAIPWASPDLQLGSVVSCRTCGNEIVPRDQIKVWKDLPSENWAEMMEFWHCHKPNDSGKPDDEALADRAYGANSAIAARPGVGFVDVTSFMFCEPDCHHLLFSPSPSETMFRSSSLALDQITTSGPGHVFCGECRTQVGLFATSCTSISLFKWQITCETLSPGRIPDLVECLAATLLAAISRSACAKSVVAPYVSEGGKGSKALHLWVLNANMVYTSSARQGKRAAMKMLYREISLDEGHDLVDSLTSNVQDISLPKRAIEAVRRALEASTALMPERERSFKDWRAGLLDRWATEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LN43</accession>
    <name>A0A367LN43_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_2018</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LN43"/>
    <dbReference type="OrthoDB" id="3431704at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000010">
        <property type="entry name" value="Fungal transcriptional regulatory protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF28">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="34"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="90"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI15865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="300" mass="32438" checksum="1BABFD978C231093" modified="2018-11-07" version="1">MTVPLAQPPAVPVKDAATTRKRRRRAPAGGASDDCFTCSKRNIKCDRRRPYCSQCLQIGNECSGYKTQLTWGVGVASRGKLRGLSLPIAKAPPVSREPKKSPARRSRANSAVSTTTTTTTSQWTEREGVIGSTQCGPIDIPTVSDLATGPFSTYDYGMSMSQPEGAACLSHAGWGYSPDMMHHHHSPAKFSLPLMTDSLSSSTDSVSDVDYLSPLSQSYSRDDMPFGGGQAAIYDSYSASQSPPSTLVLDYSRAPTSCPGLIYAHSEPSSSLPSHHQLNAYRMMRECEENHVVTCPGFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNJ0</accession>
    <name>A0A367LNJ0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_3024</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNJ0"/>
    <dbReference type="STRING" id="1330021.A0A367LNJ0"/>
    <dbReference type="OrthoDB" id="5561659at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11041">
        <property type="entry name" value="CYP503A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011084">
        <property type="entry name" value="DRMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46206:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07522">
        <property type="entry name" value="DRMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="13">
        <location>
            <begin position="27"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="DNA repair metallo-beta-lactamase" evidence="12">
        <location>
            <begin position="422"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="513"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1101"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="531"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI15979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1227" mass="136413" checksum="637E51614CD233FA" modified="2018-11-07" version="1">MSTFNGIVPEFPEIRIDFFRNRATALACFLSHIHSDHLAGLESLRSPFSVYCSAATREMLLRLERYPCRINYAKGILETRQQTYRHLARVLKPLPLETPTTIELRPGRSIRVTLFDANHCPGAVMFCRLVMEGDGKSILYTGDVRSEPWFLSGLARNPILIEYSCGLKTLDTIYLDTSFIADVPFPSKAAGIGQLLRAVARYPGDTVFHIKAWTYGYEDVWIALSRALDSPVCGPARLASGFLLLSCLTPGPQIHVDDYKLRVYGALRTSNDQHLASCAAALMGHMCANTPHPGCLTSDPHVRLHSCEKGTMCAVATGPNVVSIQPIVARLPNGEALAEQARLRMVHLNRVRHTDHFGQDFTKTIVDVKEKGRGLLPLNVAASALGEGDRAQVETALSRLIPGSERREAAASDDERTACGMPSVIRFPYSRHSSYAELCQLVDMFRPHDVWPCTVNMERWKTQGLGLSVVFLDETDLKHTDISIQSLFGRFCSEKQVFQHDVLMMMATKPSSSTWAQSCKPEDNDDGPVVDSQQTNASSSYEPSRKEAYRYMMANAAAEDDVWRPISLLSTDGGHGVADEELGPSLARHRCASHTKTVLSSPPLDGASLTASLSNEPDRRRLFRPSSFPSFVPPPSSSCIMTVLGYQVADGLTWVHVTVFCALFFLAAYVIDFLTLAHSPKDIPSFSVGNGLIAHVRNSFAHLTRHRVWMNEGHAEYGSKGLPFAIPAFLSEPAEVVLPRSMIGWLMEQPENVVSSKVAIDSIIFSHYNFLSPRLIREDVATRIVTRFLPRHLAALIPAIDAEVQKSVGRALRRVHERDDEWTSVNVWQLWLDIVPQVTNRILVGEELCRDQAFLDSMVGFTNAVNRNCLILRMFPRVLHPLLGRLLSIPNWLHWRSAHKKLAPLIERRLAEMKEDTSLSSSSPSSSPCSPSPPPPEDFITWIIRLAKREDKAWLLDASTISTCLLPLEFASIHTTVLTGQGWMLDLLSLPADEVSTAIDTLTTEIKDQAPPPGVPWTKAALQSLRRVDSSVRESQRLSNFSDGLVHRAVVAPEGLRHPDFEWTIPKGVVLTANVESTHHDEVLYVDPLVYQPFRYARMREEGGEDGKRKPSVATMDEKAPPPPPRGTATNTSSNSNPLTLGMVSTSSHHLAFGHGRHACPGRFFVAHEMKLILAQLLLKYEFRPLPERPRPGWIGPIAVPPMGACVEMRRKKVEDEMKLSSSWTEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNL3</accession>
    <name>A0A367LNL3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNL3"/>
    <dbReference type="STRING" id="1330021.A0A367LNL3"/>
    <dbReference type="OrthoDB" id="5402307at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="441"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="488" mass="52875" checksum="1DC1674664D628F5" modified="2018-11-07" version="1">MPLQQTVTIVNNSGKIISSGKKLFSIFKEAKGAYDEKKAELQSVKRSQTFDASRSIAAASRSKYEVDDDDDDDDDDDDDETVRRHHGRHHRRRRHHDRPALTESNLKTHSETSSVVSTPSPRRFSAPTMRQDAIDMDLAYGNVPPDLADRVDLDPRHGDDDGGQQRAQRLVGRVEKLLDEAHCLQHSAGTIIRNLQEKPDTAAEVALTLADLSSAVANMSPAFVGLLKSGSPAVFALLASPQFLIGTTIAVGVTVVMFGGWKIVKRIHEGQPLLPSGVPAPDRIKGGDDDDKERMDEALVVDHQLGSIDHWRRGIMSSDESADLELITPEADRATRVGRYYAKDDMDVRSYRSGRASSSSSSRHRRRGEKIAGVDNRDGLRSSSSSRSSSRRSSRAGSRAIEEGAGNGNSVDLVLRPKAQRQGDNMLKAIFRNKEKEAREGSGSSRPRSNSGNSSISGRSGGGGGGGSGGSGGSSRKRELVLAKPLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNZ0</accession>
    <name>A0A367LNZ0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_2138</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNZ0"/>
    <dbReference type="STRING" id="1330021.A0A367LNZ0"/>
    <dbReference type="OrthoDB" id="272624at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001156">
        <property type="term" value="F:TFIIIC-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070898">
        <property type="term" value="P:RNA polymerase III preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039467">
        <property type="entry name" value="TFIIIB_B''_Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929:SF0">
        <property type="entry name" value="TRANSCRIPTION FACTOR TFIIIB COMPONENT B'' HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15963">
        <property type="entry name" value="Myb_DNA-bind_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="458"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="570"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="365"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="585"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI16148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="612" mass="66341" checksum="3962A96549271C98" modified="2018-11-07" version="1">MSSMLKKKAGGLAFKPKIPSARSRPANVPSAPAPKNVESQPLVDSTREAASTGAPADPGKDFPGAGNTRSIKAPTEQPSQRDLLEPGQSTAEPKPSQDLSPPASSVAQNVSEPSSSLIPEISNITNDSIAAQADTSTQSTAGKEAATAPTLEPATKSSSSVPLPEPLSLSPAESIPVQAPVQAPVQASQPTADEAIPPAPDQSVPDQPVPDHSAPEPANTAKTTADAPPSKEKTIKKPRQAKKSGQSKEPPQKRQRKKPAKEGEEAAPRPRKRTRKADADADESPKVKKRRGRARSPTPEDAESQTVDLQQLRMADLTKDLRIGKKFSRHDELRDRERKKARSRTKASQQDDNPTTTGDAASTPQQDGSQDASDKSSSNNNNASNSSSAPTTGSQPSTTSGPQFRIIDGQIVVDQNSLVMDRHARAAQARGDLETVEENDFTRHITSSSFMTTSKLKGPNIWTADETELFYRGLRMFGTEFEMISKMFPGKQRRHVKLKFNREERHNARLIDAALTGEKTTKMDIDEYRAFTGAEFESVETIEAEQRAIGQRYELERQRIADEQAETMRKKREALFADDDDEARRKRSGNRRKGGGQAVAYGLNGEPINAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQ72</accession>
    <name>A0A367LQ72_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ras-GEF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_2234</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LQ72"/>
    <dbReference type="OrthoDB" id="28357at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF348">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR RASGEF, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="420"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="647"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="274"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1066"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1252"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="28"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="369"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="405"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1069"/>
            <end position="1078"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI16604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1425" mass="156041" checksum="D3DADD45D53235D1" modified="2018-11-07" version="1">MRSKATAGRTAHKSSVADAQLQDDSRARASSSSARRRGSALSNTTTTASVFSSSSSSTGLTVPDRIPSSSSHDHVPVLSEPFLRRFNRNPDDSHGSSTSQSRPPPARRHDLTCSQPHWSPPTPVMESLTIAVIGSSSAGKSTFIQTVLGLPRRPISDTSTVRIAVDDAHYPITLLELDAASFDLNGPRPVTWPKQVNGHILPRADAALLLYDVTNKESIRGFDKILAAFTRACLPTILIACKCDCPEDDLEIDADKVESHATFKPCVARYQTARDRPNMSREGLRAAVRSAVAHRRDEASDATLRRRAQSATNLEAPDATASRPLSRQSRHSRASSDASAPRAFPDAQPAKGQRPAGARGGNPVSDPFIEVDEEDEDEDEDEDEDEESDDDSDDGDEIPILQRGEDDDDDDDDDDDIVNKKSKPVGVTFSELVDRLLALPLSKADNNFSDIFLCLYRKLAAPAQLFSDVLVRLDRLGDDKESHYLSKMATQFRIVEVVAKWVSLYPGDFARPATRRNLEDFITNLSTEPALSMASQQMRRNLRFNVMVDDDTGWAHADDAGDAVASKLLSKDLSQLSDGISALHFSGEADGRPSHSSDASAPEMGSIASSQFMFNSHDDYEREAAMLEPRDHQPMNKFRYRIFMDISDDDIADELTRIDWIMFSSIRIRDFVRHVSLSAAEKEKCTSMRNISRMIRHFNHVAKWVANMILLRDKAKHRAQVLEKFMSIALKLRQLNNYNGLAAVLAGINGTAIHRLTQTRALVPAEVQKRFAGLVILMGTQKSHFAYRLAWENSPLPRIPLMPLHRRDLVSAEEGSKTFVGPDGDRINWKKFEVLGEVLLPIMKSQGTAYPNLTKHDTARDLILCCRMPTDDEMHEKKRSLMMVGMMQEIYQRSVQVESGTSGPVDSMAHATVSLPTTRVAGRASNVHVSVDGSLLLRLPEDSAGLTTADDLLELVETRHAWICRTGACHVGVTVCMDGEPVALADETPLAAWFGECELWQRLGLRLQYCGVERTGASDEMIFSLQHPDLSSSLVAPKGAMSAEFVAWTCRVYVCFEKPSNKSREQIRCSPSTTTAGGQNKEKKKKKMRAKIGPAILSTDDDYLYRCLTPSDRKAVDDFLSSMSFEAGGDVVGRLVASGTVRDAVQVAIGAVVCGRRKSLGGVAILKSSRSHCLVRLAPAVFHIAYLKASVTRRLATAWGLAVSDRAELLPTIATSLARMMNAESPGLRQAVEAVGGSTGMERAEVLLSSIRTPSLPRKPAEEGEVGADSHYSDEPDTLPTVVSHFGPADRIMLSTQSQSWDFGRLASQSSYSSEACSSPTPYAYAGHYHLPLAGNNESGAEGWRDAIYNQAVDGVLTFRSNLPGESCDSPMPYEYAGHSLPGEASGGVRTEGSVFTADAVQNNSETLALDPAMQRSFEDWLSAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQX0</accession>
    <name>A0A367LQX0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_1941</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQX0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI16818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="65" mass="7063" checksum="AD68B0888C5AD20F" modified="2018-11-07" version="1">MLYFKREEEDESRDSGFVRIEEELKAGEVIYSAPIDITAALYSAPIAVTIAVTSRSGAITAIALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LR71</accession>
    <name>A0A367LR71_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein L37ae</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_2183</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LR71"/>
    <dbReference type="STRING" id="1330021.A0A367LR71"/>
    <dbReference type="OrthoDB" id="10258345at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002674">
        <property type="entry name" value="Ribosomal_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050522">
        <property type="entry name" value="Ribosomal_protein_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01780">
        <property type="entry name" value="Ribosomal_L37ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="19"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI16911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="13077" checksum="3E2E4641153006D2" modified="2018-11-07" version="1">MTKRTKKVGVTGKYGTRISFDHDKRGNSRKTDKIDTDTHPDSYGASLRKQVKKMEVTQHAKYVCTFCGKTTVRRHSVGIWNCKSCKRSIAGGAYIVATPAAAAMRSTLRRLREIAEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LR83</accession>
    <name>A0A367LR83_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_1775</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LR83"/>
    <dbReference type="STRING" id="1330021.A0A367LR83"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="324" mass="33703" checksum="A891BFCA6BB3A49D" modified="2018-11-07" version="1">MASEKHSNTAGDTKQQQPGSEEPSSSKQPPNPPAYEEAVPTLSNPFQFPSNANGLLPAYDDAALGGDGSSSCSSFSPIADARPIAIPQLCPGSTAPFLSAYAPALLRHGVTVASWRSFVDTVSAFLTARVSDRAVNYAADVARQVSQGPKTFGKGVASHARAVSRDIVRNAKRGSVIGTTLAVLEGVIAIPVSTAIGAAGAALRLPGSAMDAVITAPQTPLQRANAYAAVANRDWLHARGLQAVLVTTIGLAAVLETTVAELLTRTGPVKGEDAAAQLRALEPLTAPLEVDEKAALTLSPETLWLILLPVRPRRVRSSTTSMWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LR98</accession>
    <name>A0A367LR98_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Alpha-1,2 mannosyltransferase KTR1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_3073</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LR98"/>
    <dbReference type="STRING" id="1330021.A0A367LR98"/>
    <dbReference type="OrthoDB" id="202470at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF7">
        <property type="entry name" value="MANNOSYLTRANSFERASE KTR4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017041897" description="Alpha-1,2 mannosyltransferase KTR1" evidence="4">
        <location>
            <begin position="29"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI16976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="438" mass="48743" checksum="D0A6BF95EADA7C33" modified="2018-11-07" version="1">MNGGRGVNSVPGLFLALWAWCFMWYCYCLSPAAATSTDHPPRAVLVSFARETDLPAVLSSVSQLEETFNNRYRYDWVFFSTSPLSEDFRRLTSNATAAACVYEVINDELWSVPEGASDSTLQTVELEMEPESSSAFARQMRRWKSGRFAKESRLKSYDWFWTIEPGVSISPAQFIHDIDFDVFRVMRDHGIAYGSHDSGLNEAYMRRLSQHVKSFVDDNPDLTHEEADVSWLLEAAESVSPHGQGGATDDALVVRGDGMTLDDADGGWLDDGEDEEDVGSPIEVLASRLGGIYRSSLWPTFEVGSLVFLRSQSHQSLLEHLDRSDALLDSGGTPTLSASLFLPQKSVLHFRKRENHGADEPQSTAKPKFSLVRVVGSDVNRSDSLQRRRVKAFTAERWELMAEDFGRQGGMPGLRSGNTVFDGRGFTMLGFKHGVVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRP4</accession>
    <name>A0A367LRP4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_2125</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRP4"/>
    <dbReference type="STRING" id="1330021.A0A367LRP4"/>
    <dbReference type="OrthoDB" id="550575at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318:SF95">
        <property type="entry name" value="F-BOX PROTEIN YLR352W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="139"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="610"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI17089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="661" mass="72847" checksum="0AEFA10204BE6869" modified="2018-11-07" version="1">MARLDDHGDPSPPAGQDPMPVKSKGRRRLLRGLQRISSSPSLHGLRRSRSASSPYSTRSALSCVSLVAGPSISPQPSLPTGSTSIIDLPLIEAIDGQLAVRKVDHATIPAASPTTASLPLELRCRHDGLASRAHPKARSCRWDKLPYEICIHVLSFLRPKELVRASRVSKSFYRFCFDGQLWTSFDASEFYQEIPADSLARIVVAAGPFVNHLNLRGCIQVEHYKRAEVVVKACKNLINATLEGCRNIQKHTLHTLLRTNDQLVHLNLTGLAAVTNVSCKIISESCPRLEFFNVSWCEKVEARGIKAIIDQCTMLKDLRAGEVRGFDSIATAESMFKTNRLERLVLCGCMELTDEALKVMMHGTDPELDILTDRPVVPPRKLRHLDLSRCSRLSSVGVRAMGHLVPDLEGLQLSGCKALTDAALEPILATTPRLTHLELEDVEDLTNSLLSEHLARAPCAAGLKHLSLSYCEKMSDVGVLPVMQHCVGLESIDLDNTRISDLVLAEAASMVATRSRRSTAMDEGTNKPRVTLQMVVYDCANVTWTGIREILFRNAQMVAGARRSGCAAEMIGLKCFYGFQMTVDEHQKRLLRGEAEAARRLESKWAEFMQANEEAGTDGPGHRRRRRRARETQGLNLLDEDGGGVGGGRRRARTMGACIVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LS26</accession>
    <name>A0A367LS26_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LS26"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI17255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="249" mass="27879" checksum="AA69EB3F658B3483" modified="2018-11-07" version="1">MAAKGVKVPTNVTKGEASWSLERYAEDKQDPWRPPITGNILGGKTAGGARAAAARGARSRTTDRRRRRRRRRARPDSVNNRQCRLRHGPKGKKPQRGRGVLMKGMDWVSQQLLQQAKAREARNNTLARATSGGEDGCGEMMDTKSMGCYCKSPRRSKKQKDDQKIRAARGSVIGFFARKRHTARPLISGEILSESEGHVEGNVRRRELFIYMRSEEISSENIRWLVFCQDDYSEVGEAAQIAAEPVGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LSA5</accession>
    <name>A0A367LSA5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_2513</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LSA5"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23330">
        <property type="entry name" value="P300 TRANSCRIPTIONAL COFACTOR JMY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23330:SF9">
        <property type="entry name" value="PROLINE-RICH PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016603194" evidence="3">
        <location>
            <begin position="22"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI17336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="498" mass="54355" checksum="2D81CA9F4FF7F91E" modified="2018-11-07" version="1" fragment="single">RDVFVFCFFFFFVIFSSPSASFSVTGDDGASVRSSLRFISDVVFRNRLMRRKRFCMTSAGNVRAERQTRLFLLVVFITIYLFKNSLRVFIKVHVIIIILFKPSTFTPQESQSKVKKKKNLPEMRPPLLAFTATAYIRFISLAACLPFVGASPLISPPTYPVPDKLPGFVSGSDEMGVLHQQLRNSARAKAQAQASKASCVATGVAQAHPPPPPPPPPPAAAPSSTAATTTTASCCCSVASTGFLCPISISSASSASASTFTSGSRLLSKSPSAGRSPSSSAFGPAAAASTLSGRHLHRGGMTSYGSSHIFADSDLAIILRRKSLVRRRRFSVKEAIARRHVLLCTLYRPVYSFSAFLSFPFISCRSFMCLPIQATQSKGPTLENQKQEVNAFNIHIIVIVYFDFFFLLLLLLLLLIIIPWSKHIGIVPPLYPPPPPPCNKPPASTLWLPPAPPVPAVTVPNLQRRLKTPDPFSHSAPLPSHLLYLDMLSRSMVKPAYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LSN5</accession>
    <name>A0A367LSN5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">MADS-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_2933</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LSN5"/>
    <dbReference type="STRING" id="1330021.A0A367LSN5"/>
    <dbReference type="OrthoDB" id="2284405at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00266">
        <property type="entry name" value="MADS_SRF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1810.10:FF:000002">
        <property type="entry name" value="Serum response factor b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050142">
        <property type="entry name" value="MADS-box/MEF2_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033897">
        <property type="entry name" value="SRF-like_MADS-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48019">
        <property type="entry name" value="SERUM RESPONSE FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00350">
        <property type="entry name" value="MADS_BOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="7">
        <location>
            <begin position="54"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="143"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI17453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="233" mass="25166" checksum="E1B14D7EC4821F96" modified="2018-11-07" version="1">MADITDQHDQTSPADLDDSHAAGNGNPAAESRGIKRQRPATADDDDDDDEKGGRERRKIEIKFISDKSRRHITFSKRKAGIMKKAYELSVLTGTQVLLLVVSETGLVYTFTTPKLQPLVTKPEGKNLIQVCDRHGLLACLNAPEPAPGNENGVDGGDQVESPEESAGPHIPPPGGRPGMPQNPHMPPGNYMPNMPIDPSQALAYQNYVQHRSQGYGSGMPPQAGMPPANHHQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LSX7</accession>
    <name>A0A367LSX7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_2423</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LSX7"/>
    <dbReference type="STRING" id="1330021.A0A367LSX7"/>
    <dbReference type="OrthoDB" id="1418352at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000010">
        <property type="entry name" value="26S proteasome regulatory subunit RPN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040780">
        <property type="entry name" value="Rpn6_C_helix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040773">
        <property type="entry name" value="Rpn6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18503">
        <property type="entry name" value="RPN6_C_helix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18055">
        <property type="entry name" value="RPN6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="223"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI17440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="423" mass="47841" checksum="DF2F555B866D2F59" modified="2018-11-07" version="1">MAAGESSRLQEAQKLVKTDPRKAEAIYRDITAKAPQATSDTATREYEAALISLGELYRDERKTQELVDLVRESRTVFSSFAKAKSSKLVRQLLDLFKDMPNSTDTEAYITKDCIAWATAERRAFQRQDLQVRLVALYMAKQSYYEALTLINGLLRELKRLDDKLKLVEVQLLESRVYHALGNIPKARAALTTARTSAASVYTPPLLQANLDMQSGMLHAEDKDFNTAYSYFIEALDGYNSLDESVKAQAALQYMLLCKIMLNLVEDVNQLMASKQAVKYGGKNLEAMKAIARAHSNRSLDEYERALSLYRYELGSDAFIRNHLRRLYDAMLEQNLIKVIEPFSRVEMDHIAKMVGLDTQQVERKLSQMILDKVIIGVLDQGAGCLIIFDETQRDESYDAALATIEKLSNVVDVLYTNQASLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZD3</accession>
    <name>A0A367KZD3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_8322</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000027">
        <property type="protein sequence ID" value="RCI07527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZD3"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI07527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="61" mass="7042" checksum="E3BFE67800E85C39" modified="2018-11-07" version="1">MNFIQNPCNSEYYSVKPRRSFIRETAPVKPRRRNHAAGLTFYEFFGGGRQGGTRDGVFWGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367KZX0</accession>
    <name>A0A367KZX0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cleft lip and palate transmembrane protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_5719</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLPTM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000024">
        <property type="protein sequence ID" value="RCI07716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367KZX0"/>
    <dbReference type="STRING" id="1330021.A0A367KZX0"/>
    <dbReference type="OrthoDB" id="378564at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008429">
        <property type="entry name" value="CLPTM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347">
        <property type="entry name" value="CLEFT LIP AND PALATE ASSOCIATED TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347:SF0">
        <property type="entry name" value="LIPID SCRAMBLASE CLPTM1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05602">
        <property type="entry name" value="CLPTM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="498"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="523"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="619"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="626"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="645"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="666"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI07716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="676" mass="76152" checksum="8B5EAF18463F26E8" modified="2018-11-07" version="1">MASSSVGKRQPETQPPVPVPQEQQQKKNGGFSLNRLVFGVAIYLALNLIISLVMRKDQRSVSVTDPETGQPVAVAANMDGIPPFQLRPKTLNEGAQYRPIPRRVAPIWPQDSLVDMVVTLSPSFNPRPIAQTPAEYMVLRENGFRMDDRSDVRTVDTKFTVPPAVQNNGTLWGHFYIGLAGSELDPHEAGFDSDKAYHFVHPLTQYLAKKRVAKTRNLLDARPDKEPEEPVPAGPVIASHYHANASFAFVPGMGVKDLSQLHPGLGQFVRLETTGARDGSGENGWYYPLLFVNTFWQLTSHMTVLNETVKELPLHIELKNMPFWQFQLLASIETNSKENARQAAFGASLPGGGDGTEIEMVKEIFMDTNPILLAITAVVTVAHLVLETLAFGSDIAHYRKKKDNVGISVRSILANVVMQAIIFLYLLDNSQNTSWMILGTQGVGIVIELWKITTVVNVRLRAAAPGSMMPWRLVMEDKHKLTETEAKTKEYDEVAFRYMYVVAVPLLAAYGVYSLVYDTHKSWYSFVITTLVGSVYAYGFLMMVPSLYINYRLKSVAHMPGKAMMYKFLNTFIDDLFAFTIKMPVLHRLATFRDDVIFFVYLYQRWAYKTDYTRVNEFGQGGEDGEEKKKEKKKEEEEEADERDDAVKRAKEEEEKEEEKVRATGRDGGGNSARRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0H5</accession>
    <name>A0A367L0H5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5694</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000024">
        <property type="protein sequence ID" value="RCI07722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0H5"/>
    <dbReference type="STRING" id="1330021.A0A367L0H5"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009691">
        <property type="term" value="P:cytokinin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.450:FF:000018">
        <property type="entry name" value="Lysine decarboxylase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005269">
        <property type="entry name" value="LOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00730">
        <property type="entry name" value="Rossman fold protein, TIGR00730 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31223">
        <property type="entry name" value="LOG FAMILY PROTEIN YJL055W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31223:SF70">
        <property type="entry name" value="LOG FAMILY PROTEIN YJL055W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102405">
        <property type="entry name" value="MCP/YpsA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI07722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="233" mass="25031" checksum="D045285391CBC9BF" modified="2018-11-07" version="1">MTSENIPNGTASNGTTPPTKICVYCGASAGTSPAHLEMARQLGTAMAARNVQLVYGGGTVGLMGEVAKTLCELSGPDSVHGIIPEALVKYERDSTYQTTNSDNQVVPELARYGRTTVVPDMHTRKKLMAEEVFSGGPGSGFIALSGGYGTLEEIFETITWNQLGIHKNGICLLSVEGYWDGIVQWINKAVEHGFVKEANKDIVVTATSAEDAIIALRDYKVSEDIFKLKWGTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1A1</accession>
    <name>A0A367L1A1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_6248</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1A1"/>
    <dbReference type="STRING" id="1330021.A0A367L1A1"/>
    <dbReference type="OrthoDB" id="5428863at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF1">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="245"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI08177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="692" mass="75391" checksum="0A4EC9727C961CE8" modified="2018-11-07" version="1">MRRKLSKMLLLPTRRPESEPGLRRRSTAAALPELHQLPPRPSATGDDGATASGCIVVDECSELCDRCAALDFPRILDWEAGQPRAWIPLSHVLQPLTTNCPFCLFFRAMLGPDAAAAGLGGKFTPYLRMRLAFERLAGLGEKHEIARCVLAEVVTRNRALPRGFIVKTDDVGERRRRLRGRIVPRLLDLSLLKGWMDHCREAHAATCCRPSEGAMVSGLRLIDCAERTVVCADGLVLDDGDDCGYVTLSYVWGDGTDDDDDDDDDDISDGSRLPDAIPAVFADAMTLTTSLGMRYLWIDRFCLAPLTADERRRQNRLMDDILSAASLTIIAASGTSRHQGLSGVSVPRDAQLSLKTDTGLYTTTLLRPDLDTAASPWGNRAWTLQEGLLARRRLVLGRGQAYFQCRALHCVESVALPLDLDPAVDLGRVFPDLLDPGRLCTHIGAFMERSLARVGDRLDAFGGLLRTWSRDGRRPVQHLLGLPLFHPEAFVNASAGVVSQTDRLAVALGWMPDRTALVGGSFPSWTWLSWTMDPGQGRGFNLGLVVGGVVQDGVCAPPGMEMSVGFVTGAVLSWEIDGDAVVRKSDAVSFLRLYTFCTHLCLRASSSSQDWTLEAPALPPHGQDQGGAATALVCRHDGWDPTRRLIRLGAVSFDHLGLRMGTDDAGLACGLLRGVGGEGEHLRLHMSEVDLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L1T3</accession>
    <name>A0A367L1T3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_8955</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L1T3"/>
    <dbReference type="STRING" id="1330021.A0A367L1T3"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001113">
        <property type="entry name" value="RNP domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050502">
        <property type="entry name" value="Euk_RNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025">
        <property type="entry name" value="OS02G0815200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="172"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="41"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="260"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="263"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI08381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="291" mass="31589" checksum="9A37DAF56A5523A5" modified="2018-11-07" version="1">MHLPPPPTNPRTDRPVGYAFVDLSTPTEAQRAIDELSGKEILGRKVSVQLARKPESPGEKGEVSNGDVSGTDVSRRRPSGRGRGRGRGRLARTTRGGRFGDGGDDKRDDENADIAATDAHAAADGTHEVQPLKDITNKNQTDDNAKNLKAHARPQRERRERGPPADGIPSKNKVMVANLSYDCTEEKLKNLFEGYGCSSAKIALRPIPRFMIKKLHARGEPRKGRGFGFVTLASEEEQQRAVAEMNGKEVDGREIAVKVAIDSPDKTDEDANAHQGEEADNNGCDAPLIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L237</accession>
    <name>A0A367L237_9HYPO</name>
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        <recommendedName>
            <fullName evidence="4">ORP1 like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L237"/>
    <dbReference type="STRING" id="1330021.A0A367L237"/>
    <dbReference type="OrthoDB" id="4161595at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051647">
        <property type="entry name" value="Mediator_comp_sub12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46007:SF12">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46007">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="13"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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    </feature>
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            <begin position="831"/>
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        </location>
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            <begin position="32"/>
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        </location>
    </feature>
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            <end position="806"/>
        </location>
    </feature>
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        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RCI08467.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="855" mass="94679" checksum="A2E21E15FB5CACB2" modified="2018-11-07" version="1">MDVTLLLNQSASFANRDAASRESTPPYAAAGLSTAPSTALPTPSPERSLAQRESEPRQTRGRTPWNAGGYSLPLQSDAKMRSASTFSYRSARDHHHHQPDSAQTASLHSRHMSVDSDVSVSRGGEAICGRSRPQQQQREQQQQQQQQQQQQARLDEQSTTTPRHRLSDSYSSLSSYSSRQSMPHSRISSITTISGGYPSLAELPIFESSVVDGHDHHHQHFGDDDDDDHVKRLLHLPPPSSSRDDGSPPPPAEAFSSPCSRYPDGPRPSLSRASHLFLSPKLHKRAISAPDFASLSGSRFPRPPPYNLLPPPHHHHHHHHQQQQQQQQQQQQQQQQQQRQQQQQQQQQRQQQQQQQTMGGGARGQASTSRAREMVDLMSSVEDSSPELAAKDDGSNNEGEPRCMFVANCDTGSQLRKAISHLFGRNKSCTLKIPKEVWVYYCRKHYQRIRYRNARTYPSNQMELVKVQILRLQTWSEANQAKASGPYIKQWTLSLRKREQNRLDSGKGNDDVVAAAGDDDHGGSVVPDWIIQLVGDGYTTDKMLQVAERLHKDIVDGVLSQVPEIEFLPDIVDDNNDCSKPSRSRRSNNCSKNPKRKANDTSRQNSVVGGGDVCSPVMREEDEPMMTSPSGKRARLNIERGPPYYNNNNNNNNNNNHNNNSSSNNNNSSSLSSSSSSSTNMPPYSIYGGPPPIARAPHVVPKFRTLDFGGARAAREGEEQSPPTRFNGFEDLASFGPRFNGGMTLPSIRTQMLPGAPRSMHQRSASAYTLASRPASSFPRPSSSGDEGAVYELGCSSSSSSTVSSSRYPLPHQHYRHWTAAEIQSQDQGWAEGGYAQSGGGHDMLSPCSGLNHRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L278</accession>
    <name>A0A367L278_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_8968</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L278"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI08524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="31" mass="3166" checksum="39C1D972F4E80B27" modified="2018-11-07" version="1">MTAISTARRSLYSAPIAVTSRSGAMTAIAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L279</accession>
    <name>A0A367L279_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_8889</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1330021.A0A367L279"/>
    <dbReference type="OrthoDB" id="3197614at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40130">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40130:SF1">
        <property type="entry name" value="SPINDLE POLE BODY-ASSOCIATED PROTEIN CUT12 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="75"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="259"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="440"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="501"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="393"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="463"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="101"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="194"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="265"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="454"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI08518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="523" mass="56827" checksum="8537C10B4CBDDB69" modified="2018-11-07" version="1">MDMSPLVKAHDHARAAAVATRQASDTTVAISEHTQAAGEFANAAGHTTSLEALRTLKLLEEHHTRLAALLKLPPSSSSAVGIHPAEDELSSENYPPPPSPEKARPVVEGAARKDATPPRGPHASPRFPSRDMSSSIASNLATARGIRSKHRGRPLSPSVSNDQAPGNVDPHPRRDGSSVKMQTIMNHQAGKPIWVPPMPSSPPQKPPAPTTVAPLPRPDDDTAEDGGYARFYNTFGSLINKISAPLAFAGLPLIQEESSLASKPAEASQHSSASAVASTSPLVVKRNPPRPQSSGTLEPDLSKIYSKATMRALARDGHSASDSFYVVPTSGHTMSYANILTYAEKEKRRLEASTQGELVAAGDEDDEDFVDARETLIPPSSGTRRKVQRFQSEKELRNINEELSLENKSLKDMLDNVSKRLHAFEASSQHSAMALAESYRVMRPGSPSSGGGRQADDVMRRRAQDAEEQLVVVMKQLDRLERDNRKMQRTLDKYRDKWEKLKAGAKARREAQVGESIEDARQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2K0</accession>
    <name>A0A367L2K0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_4645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2K0"/>
    <dbReference type="OrthoDB" id="5304511at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI08659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="423" mass="48103" checksum="EF9130830294CDAF" modified="2018-11-07" version="1">MSLPSALNLVTVGDDIHRLILDKLPTVSSLVNTLEASAAIRRSFEPYSRSIATRVIENELPPCIWRHAVVCQMLANGTIRTPTLDGTWEFGIESCIQKIRRVTDAASQQTVSLDDAVAMSEFGIKAMYLAVQFAGGCFRGKDHVHQPLEESLSSTPMSAQEAGRILQSVYLFDMLASLCKNMTMEKKRGESTTRFARRCTKRVRHIQRCIVREMMSPWEFYQVIGMQAFFRRVVHGLGCSPSYMERVMPGILVGGVRLMHDILEKQHEPEKMHAFVGRLQEEALGRPTNAFGLIVSRGESWTWTRTKGRSLNEYRQLGRWWDVEGWKTWKLLEDVQDRLSGSGDEVMQAVLSDNLADFENRTDLWSVALWDSTRWGDVVRHCLGDSPPRLSHWSAADVGIGLLYNPRLATMGREWMVRRERAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2N9</accession>
    <name>A0A367L2N9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Smr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_8804</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2N9"/>
    <dbReference type="STRING" id="1330021.A0A367L2N9"/>
    <dbReference type="OrthoDB" id="3231855at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013899">
        <property type="entry name" value="DUF1771"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053020">
        <property type="entry name" value="Smr_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47417">
        <property type="entry name" value="SMR DOMAIN-CONTAINING PROTEIN YPL199C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47417:SF1">
        <property type="entry name" value="SMR DOMAIN-CONTAINING PROTEIN YPL199C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08590">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01162">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="2">
        <location>
            <begin position="98"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI08482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="238" mass="26985" checksum="491A1278645E53DC" modified="2018-11-07" version="1">MAIPMTRLGGRALHAGDNDDVEREFDHLRGLARAEADKRNACFDRSRQAYKSGDGAAAKELSNQGKMHDSKMDEYNRQASDYIFRENNAPGRVEADAIDLHGQFVEEAERILEQRIRADQARGQTHLHAIVGKGNHSAGHVQKLKPKVEELCRELGLRYQTEENAGRIYINLQGGEPVPPQQPPHHHHQEPHHPPPPQHHQPPPPSQQQPQQQQQQQQEVDIVQRIIQKLEKACCVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2T7</accession>
    <name>A0A367L2T7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2T7"/>
    <dbReference type="OrthoDB" id="4864073at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="362" mass="41012" checksum="AAD0F6FBB82BBFA8" modified="2018-11-07" version="1">MPCPGRCFAFIGNKPEHVDHDKHAEPVRTWYFCPVHRKFHAMLVCVRGPQPRCGECAVVFFAGNSHACWFLNDDLAAVMTDSETRMRDSFDDMDALLREIEEARGRRLSLGDATMDDFVVDDTALLDEIPREDETYIKLGSELLPHTRAGIKNLYLFPFLTFEGFPAYQPCSVNIDFLGLFTPLDCLETDADPVFRQARTWSCIVQARHRLPKPLRWVLATIYNFSYEMMRSEVDEPTLWKMRAWLLHWYSVADRLLVAFDIPASTPGPDWFSSPKPAQARARLTQRAPARKSGSRPSSSADGTVIHRPMPRRRSSESPVLSSDILVWLRSLQCAEGCSATDRSTFPSRGHELNPSSTAIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3A1</accession>
    <name>A0A367L3A1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitin synthase</fullName>
            <ecNumber evidence="2">2.4.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_4909</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n) + UDP-N-acetyl-alpha-D-glucosamine = [(1-&gt;4)-N-acetyl-beta-D-glucosaminyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16637"/>
            <dbReference type="Rhea" id="RHEA-COMP:9593"/>
            <dbReference type="Rhea" id="RHEA-COMP:9595"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17029"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="EC" id="2.4.1.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:16638"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.16" evidence="2"/>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI08906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3A1"/>
    <dbReference type="STRING" id="1330021.A0A367L3A1"/>
    <dbReference type="OrthoDB" id="26569at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030428">
        <property type="term" value="C:cell septum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004100">
        <property type="term" value="F:chitin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006031">
        <property type="term" value="P:chitin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04190">
        <property type="entry name" value="Chitin_synth_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004835">
        <property type="entry name" value="Chitin_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013616">
        <property type="entry name" value="Chitin_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914">
        <property type="entry name" value="CHITIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22914:SF38">
        <property type="entry name" value="CHITIN SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01644">
        <property type="entry name" value="Chitin_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08407">
        <property type="entry name" value="Chitin_synth_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="689"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="728"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="759"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="803"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="935"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="968"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin synthase N-terminal" evidence="13">
        <location>
            <begin position="267"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="52"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI08906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1031" mass="114199" checksum="F562F2CEABB17076" modified="2018-11-07" version="1">MHRPKTPPARPPDYSYGDGQGYSYGYGDDQGHQTPTTTAAAAAAAVRLLGESPECSPSVAYASSDNLTGNNRPLMSPSRPSSSAGGRRLYQPASSASFRDSAPSMPPPDSKYVPFAGRDRPWTPSPDRGTRPPPPAVSFEPPDLNGGPRPGTPSSRYGGSPRRPLPPAPLFSSVSARSSRTMADEMDDADDDAAVTIPLDAGGCAVDDDDGDDGDVFSPIKERGSYSSLSQETLNEEPVPQDVKIEHYGPAPNGAQERRGVRAPQMSRKEVQLINGELVLECKIPTILHSFLPRRSEVEFTHMRYTAVTCDPDDFVARGYKLRQSIGRTTRETELFICITMYNEDEICFTRTMHAVMKNIAHFCSRSRSRTWGEAGWQKIVVCIISDGRDKINARTLDALAAMGVYQHGIAKNYVNNRAVQAHVYEYTTQVSLDADLRFKGAEKGIVPCQIIFCLKEKNQRKLNSHRWFFNAFGKALNPNVCILLDVGTRPGSNSLYHLWKAFDTDSNVAGACGEIKAMKGKLGSNLLNPLVASQNFEYKMSNILDKPLESVFGYITVLPGALSAYRYHALQNDETGHGPLSQYFKGETLHGQRADVFTANMYLAEDRILCWELVAKRGERWVLKYVKGCTGETDVPDSVPEFISQRRRWLNGAFFAAVYSLFQCRQILATDHTIARKVLLFIEFTYQLLQLLFTYFSLANFYLTFYFVAGGLADPQTDPFGHNMGSVIFTVLRYTCVLLVGTQFVLSLGNRPQGARRLYLTSMVLYGIIMLYTSFACIYIIVRQLTSRHRDGEGLLSMGNNVFTNLVVSMASTIGLYFLMSFLYLEPWHMLTSSLQYFLLLPSYICTLQVYAFCNTHDVTWGTKGDNVLKTDLGTAVGHAGGQTVELDMPSEQLDIDSGYDEALRNLRDRLAVPPAPVPEAQLQEDYYKSVRTYMVVSWMVANGILAMAVSDVYSSRGLGDNMYLRFILWSVAALAIFRAVGSTAFAVINVVNVLVEGRLRLSVKVPRWLGGLGGRLSDTVSSVGSKLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3I7</accession>
    <name>A0A367L3I7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_4997</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI08996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3I7"/>
    <dbReference type="STRING" id="1330021.A0A367L3I7"/>
    <dbReference type="OrthoDB" id="2123952at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="16"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="53"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="546"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="546"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="586"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="607"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="630"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="666"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI08996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="728" mass="76347" checksum="08AF184CB197F001" modified="2018-11-07" version="1">MSSAVVRSTALRAGGACVRCRKGKTKCVYENGRAPCKNCAKGMHECYLPSESMAHHHGQSPARHSSSTHHRPARDNAPSSGAGGSESRQQASGSTSSRHVQAASEKLTPELIAECERVVSKTFPACVAFHKPSFVQQLKNASLESTLVYGLLTCAARSSPGLIRRYGSPTQAAETFAAKAIALVNQNLDHPNLADIQALCLLIIHEWGTRNAVRAYIYLGQASRMLQMYRILNSHHASDNADQFLRDESFRRTLWLVYVLDCLLTSTPGRFSALAAQDTADIALPCSDINFAFGNAVHVKTLAHHLAVSPVPSPSPSPIPTGDVGEFGHIVLAASIWRDVVSMLTVSPLQDFNEESCTSLIAKIEGLRASLPMQFVDKPGQINLHMTMGSGYTFAVLHCLLHCATVFVQRRRLLQEVTAPGFTLESLRASPRCHDIVDRLFTSCHGTISLLTAVEAGVEKDQATCFPIFMLFSSFTASATVAYLSLKGLTPPNTAETAAQIVKDGLRFMHDGTENWPLMTSWLRHLTVMQRVLNNDAAAAAAATAGSGGSVSSRHGSNSHQGGIKDEAESEADTNPDGMDYEHGSASGGAGGGGGGGGGGGAGGASSGQNEAAAAAARSVSESGREDSEPPAAAAPRRPGVTTINGGSGGASTPATANSPPPAAGQASSMQGGQEAKQSSPDAVSNGMAPNQEGQTTSQDMTAPELCQAFERQLLDLDDLAAFMGGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3M8</accession>
    <name>A0A367L3M8_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_4913</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI09029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3M8"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF43">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="305"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="447"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="482"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="550"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="76"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI09029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="593" mass="62920" checksum="5CB4C0402DAFB785" modified="2018-11-07" version="1">MEEKALTFPASSSRAEDVAQSLGCPATGDAIINDPASGDKRSAINEIVIAGREDPGSDGFSNNSSPVISTRRFWLLSFGVCLGLFLSLVDSSIVATSLYSIGADFQTVEKVNWVALAYTLAYVGCAVTFANLSDLIGMHDAFLVAYAIFFIFSMACGFASSLTQLIAFRALQGIGGSGLYSLSMIILTDICPKDSRASVGIMIGITIACSGVLGPALGGILTHFARPRLLLRYPSKRLMKCSGPIGFVSLSICLTTWPKGGHFGMKRRSSRPGFDFVGSALVIASSGLIVFAFQKAGESPNGRVWGEAIFIAPLAAGLFSLTALLTWEFRVEKRSGDSFSPAFPLRLFQNRTYRAGAVSTLLLGYPYLLIMYSFPLRAQVVSQKTALMAGFMLLPMLGMSAVGSVISSKINNKRNFFRETLLAGACCMTVGTALLTTVSGAQDDKKALGFLSFSGLGFGLSAAAATNLVIDEASDSDQAPAHGILALLRIFGGSLGISTSTILVHTEARKYLVGILTEEERAAKGRLGNKLSEFQWKAIRHVHTSAFSRGMVAASTVSGAAVLLALIAVRPRKKSSGRERRTDDSNGADARNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3T9</accession>
    <name>A0A367L3T9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminotransferase class V domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_5060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI09089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3T9"/>
    <dbReference type="STRING" id="1330021.A0A367L3T9"/>
    <dbReference type="OrthoDB" id="5978656at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43092:SF2">
        <property type="entry name" value="HERCYNYLCYSTEINE SULFOXIDE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43092">
        <property type="entry name" value="L-CYSTEINE DESULFHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="3">
        <location>
            <begin position="41"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI09089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="446" mass="49703" checksum="1EABD0BA926AFC61" modified="2018-11-07" version="1">MAQPQPRQPKQGSYGATPRTIHSRHLEYQQRSESAPDSYMRYHFPTLLDGSRRAVAKHLKAPPETIVLVTNATTAVNVVLRNLTWSEDGKDEIISFSTIYGGCGKTIDYITDTNDLVASRVVQVAYPDDEDEAIVSRFRDAVSASREQGRRPRIAVFDMVSSQPGVRFPFELVVAACRELDVLSLVDGAQGIGMLPLDLSALDADFFLSNCHKWLFVPKACAVLYVPLRHQHLITSTLPTSHGYVSTRAAVRHNPLPRDETKSQFVANFQSAGTVDNTAFACVADALQWRDKELGGEDRIVRYLWWLAKAGGRKVAHLLGTAVIDNKKGTLTDCAMVNVWLPVRTASSSSSSSSSSSVEFHHDLLLPEGESPVAIAWATSTLVTQYKTFIPITVHRGRWFIRLSAQLYLDLDDFEWAARTVKEVVDRLRRDEHKQPEEKASEKPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3X1</accession>
    <name>A0A367L3X1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_5022</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI09121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3X1"/>
    <dbReference type="STRING" id="1330021.A0A367L3X1"/>
    <dbReference type="OrthoDB" id="2988756at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF2">
        <property type="entry name" value="SRPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="13"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="27"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="285"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="334"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI09121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="349" mass="38987" checksum="CFB2744CD940295E" modified="2018-11-07" version="1">MSSYHEEGVPAEFWVNLSLGTVLILTRIVVRWKTQTFRGLAVDDFLMVAIAPLSLAGAAAGYIVEAETHGLSNSGMTPEERKALDPNSSEFRLRKQGSKAHLFGWILYAVLLWTLKLSLLFYYRRLGDRVDNMKLKVNLGFAFLALTFMAVIGSIVFGCMPLSKNWQINPDPGDFCHPSESNLLAWVVLWTDMTTDLFIIWIPLPMIWRTRISTRKKIGLIIMFSAGILTIIMGILRCGFILLEGDVVGNIAARWSDREVLVALILTNVPVLLPLIRRRFWPRSKVSNGRSRSGSATTETATSDGKKNHVSPLSVEDGENFTLPIMSNSTTPLDGEKGNYHSTRVEEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L497</accession>
    <name>A0A367L497_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_1533</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L497"/>
    <dbReference type="STRING" id="1330021.A0A367L497"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17963">
        <property type="entry name" value="DEADc_DDX19_DDX25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="12">
        <location>
            <begin position="94"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="127"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="324"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="7">
        <location>
            <begin position="94"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI09249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="505" mass="54830" checksum="D443C6DE934061C2" modified="2018-11-07" version="1">MADLASRITDPKEDAAETPAVVETAADTAKDTAADSAAESTADAATDSASVANAQVDGTLEGLGGSGLQEPEFEVEISLSELQKDANTPFHSATTWQELGLNESILKGLLSLNYYKPSKVQGKSLPLMLSDPPRNMLAQSQSGTGKTAAFVVAILSRVDFTQPLQPQALVLAPSRELARQIEGVITVIGRFIENLKVATAVPGALPRGEPVRASVIVGTPGTVTDIIRRRQFDVSKLKVLVLDEADNMLDQQGLGDQCMRAKTLLPKQIQVLLFSATFPDKVNSYASKFAPDAHTLKLQRSELTVKGISQMFIDCPDNSTRYEILCKLYGLMTIGQSVIFVKTRESANEIQRRMVNDGHKVSALHAAFDGNERDELLAKFRNGENKVLITTNVLARGIDVSSVSMVINYDIPMKGRGDMEPDTETYLHRIGRTGRFGRIGVSISFVYDKRSFDALSKIADNFGIDLVRLDTEDWDDAEAKVKEVIKRNRAQASYAPSATDAPVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4A0</accession>
    <name>A0A367L4A0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16 17">Ketol-acid reductoisomerase, mitochondrial</fullName>
            <ecNumber evidence="5 17">1.1.1.86</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15 17">Acetohydroxy-acid reductoisomerase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14 17">Alpha-keto-beta-hydroxylacyl reductoisomerase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">L249_1571</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate + NADP(+) = (2S)-2-acetolactate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22068"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58476"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP(+) = (S)-2-ethyl-2-hydroxy-3-oxobutanoate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13493"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:49256"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.86"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="17">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 17">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 17 18">Belongs to the ketol-acid reductoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.86" evidence="5 17"/>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4A0"/>
    <dbReference type="STRING" id="1330021.A0A367L4A0"/>
    <dbReference type="OrthoDB" id="10255643at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00056"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00060"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004455">
        <property type="term" value="F:ketol-acid reductoisomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000003">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000005">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000013">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000167">
        <property type="entry name" value="Ketol-acid reductoisomerase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013023">
        <property type="entry name" value="KARI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000506">
        <property type="entry name" value="KARI_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013116">
        <property type="entry name" value="KARI_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016207">
        <property type="entry name" value="KetolA_reductoisomerase_fun"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00465">
        <property type="entry name" value="ilvC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371">
        <property type="entry name" value="KETOL-ACID REDUCTOISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21371:SF1">
        <property type="entry name" value="KETOL-ACID REDUCTOISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01450">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07991">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000119">
        <property type="entry name" value="Ilv5_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51851">
        <property type="entry name" value="KARI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51850">
        <property type="entry name" value="KARI_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 17 18" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="13 17 18" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="8 17 18" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 17 18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 17" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 17" id="KW-0521">NADP</keyword>
    <keyword evidence="11 17 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="KARI N-terminal Rossmann" evidence="20">
        <location>
            <begin position="75"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="KARI C-terminal knotted" evidence="21">
        <location>
            <begin position="282"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00072637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRNR" id="PIRNR000119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="RCI09256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="431" mass="47996" checksum="C2BA0B3D6EB8F3E5" modified="2018-11-07" version="1">MMASKSLSRALRAPTTTTATTARQLAPSPRLHHSLLSTLATTSRGRLLRASSPAAAATRPMMQTRGVKTIDFAGVKEDVYERSDWPQDKLRQYFKNDTLALIGYGSQGYGQGLNLRDNGLNVIIGVRKNGKSWNDAVNDGWVPGKTLFEVDEAISRGTVVMNLLSDAAQSETWPAIKPQLTKDSKPPFEPTFVDADSPWQTLYFSHGFSPVFKDLTKVDVPEDIDVILCAPKGSGRTVRSLFREGRGINSSFAVFQDVTGKAEEKVIALGVAIGSGYLYKTTFQKEVYSDLYGERGCLMGGIHGMFLAQYQVLRERGHSPSEAFNETVEEATQSLYPLIGAKGMDWMYEACSTTARRGAIDWTPKFKKALLPVFRDLYDSVVDGTETKRSLEYNGQKDYREQFAKEMKEIRDLEIWRAGQAVRSLRPENQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4E3</accession>
    <name>A0A367L4E3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Heavy metal tolerance protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_1497</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4E3"/>
    <dbReference type="STRING" id="1330021.A0A367L4E3"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000041">
        <property type="term" value="P:transition metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18583">
        <property type="entry name" value="ABC_6TM_HMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000186">
        <property type="entry name" value="ATP-binding cassette sub-family B member 7, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF651">
        <property type="entry name" value="HEAVY METAL TOLERANCE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="363"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="692"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="262"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="947"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="268"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="970"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="991"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1011"/>
            <end position="1034"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI09281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1034" mass="115887" checksum="83AE5BA08BFBDE90" modified="2018-11-07" version="1">MVADDENLSSRRGSDHGRPDTLVDVILRETQYFYALLLLVTFLTGAAWYSVYNVKKQELLAQPKAKGPGGKPLPATKRKKRDNNGERKLGPSFGPAAKIVFRYLAFVVFATYVASAVALLNHAFWHENPYEWSKQGLPWAGEWTVVHVMGSTFFYLYLLFSLFDWRKGPNVVHLTVWILGLVGESVMFAATLIAAAQCHFMPRLASDSSDGCVDYWAKVDLLLYFLRALHLLALICLFCMAWVCKLRHHDVRVEDGRVTESTPLLNRASRDEPGLDDHRPDHQTTTGRHSTSSPPDAADNDNANDDGGSRPPGKGFPGKDEPAAFYRPDKLPHRTWWEYLRGYSLFFPYLWPKDTLVLQLHVLVCFALVILQRLVNMAVPYQIGRVVNKLETAIKDVRNGQPLTTQNFPLADCAILGGLWILQGQSGLLGSLRSLLWIPVSQYSYRGLTTAAFNHVHSLSLDFHLSKRTGEVLSALNKGSAINQFLEQVTFQVVPMLFDLFLSISVFYFQYGPLYAEINLVDTCWYLYMTIKMASTRADQRREMTNADREEEAVKNDSISSYETVKYFNAEEYEANRYRDRVAVFQAAEAKVQMGMVMMNICQTLVFNLGRILAAVVCGWQVAVGMRRTGDWFTVVSYLTQLQGPLNFFGTFYRTVQQAMISGERLLELFKIEPGVVDAPHAVPLENFTGHIRWKNVSFAYDKRRPALRNVSFECLPGTTTAFVGESGGGKSTLFRHMFRYYDCHKGCIELDGKNVKDLTISSVRSHIGVVPQDTSLFNESLMYNLKYANPQATTEQVHAACAAASIHERIMSFPDQYETQVGERGLRLSGGEKQRVAIARTILKNPRIIMLDEATSALDTHTEQEIQNNVWEVGQGRTLLVIAHRLSTITHADQIIVLHAGEIVERGTHQELLAAQGRYASMWEKQIRAERALDKAREATMKANKAMKRANMNTNSEVAEEQAEEYHTLGSSGILTDNDTSKSKADEACSSSSSSSDSSSSSSSSSSDGDSSHEADRLAKRHSDAGSGHESRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L589</accession>
    <name>A0A367L589_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_4140</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6"/>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L589"/>
    <dbReference type="STRING" id="1330021.A0A367L589"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033096">
        <property type="entry name" value="PPPtase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="8">
        <location>
            <begin position="108"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="197"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="197"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="222"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="379"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR033096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI09603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="421" mass="45862" checksum="DFCAF2DBD6CBF452" modified="2018-11-07" version="1">MSDLDKAIAQLRACRPIPETQVRELCHRARELLIEEGNVVTVTAPVTICGDIHGQFHDLMELFRVGGDVPETNYLFMGDFVDRGFYSLESFLLLLCLKVRYPDRMTLIRGNHESRQITTVYGFYDECLRKYGSANVWRYCCDVFDYLALGAIVLGASNALSGGDDDDGDEIDVDDTEIEVCDQSGAVISRFSRQHSDHPLLDGMSDPRPKANGAAAERTGPPGSGASGDGDGSIGNPAGAVLCVHGGLSPLVDTVDKIRLIDRKQEVPHEGAMCDLLWSDPDDIDGWGLSPRGAGFLFGADIVKVFNHRNDLSLIARAHQLVMEGFKEMFDASIVTVWSAPNYCYRCGNVAAVLELCEDPSGMGVFARSNGDAGRDYVPPVPGAPPPTPKNGPARRYRVFQAAPQDSRGMPAKKPVADYFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5K3</accession>
    <name>A0A367L5K3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_3970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5K3"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI09697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="182" mass="20115" checksum="21D1BC1D8FFED319" modified="2018-11-07" version="1">MFNAANTMNKSPRLPPLPSSPFPCPALPCPALPLSIPIDGRTLGIPFLLRRRATCLSSSLFLPSSLGLVFFIPSLQLREQKKKKTPMPHHPFPSSSPLLPEGALGSGTSRRKEAGGGKCKDNPVHREGRDVNQDPRVEGEREQRRHDDNGWIETNNVVAIEKKKTRDRKKKGGGIHDSIMTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5Q0</accession>
    <name>A0A367L5Q0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5Q0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="201" mass="21349" checksum="A1D21E78EC930841" modified="2018-11-07" version="1" fragment="single">MAGKGRSVQMGLFLSWVFQRGEHLARVPRVLVFPLFAPPPSPFLSFYPRPLFGCSCLNPLDAGALGNCSITAVGSLLGHSGEPHAKRGREKNKDAEIQTRAAATKITARSKGSGNKEGDGGEGGGKAEGLNRRQGLGWAWKDCIASGGDGKKKKNHGKCHPKKAASQCVGRPSGKGNDGWKRVDVDGWREVKGGTSAMLHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L617</accession>
    <name>A0A367L617_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_3828</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L617"/>
    <dbReference type="STRING" id="1330021.A0A367L617"/>
    <dbReference type="OrthoDB" id="2140489at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36986">
        <property type="entry name" value="UPF0643 PROTEIN PB2B2.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36986:SF1">
        <property type="entry name" value="UPF0643 PROTEIN PB2B2.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI09662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="203" mass="22582" checksum="C164F17D925FB5E2" modified="2018-11-07" version="1">MATPATQTAVPVDVLSSASQGRFIVQSPYVEPAHQLDLDTLDHENEALAKALGGLRAVRDDYATAPYTDSFNWSEVMSEVRRLANASERAFRETSFYIVAFRSQIKPSTEYSQLGELDKAAHAEAVASGGFLKYWFGMPDAELRNLATCVWRSRQDAMDGGRGPAHRKAAGSTRSLYAFWKIDQYRLTIREGAAGWVIEPWTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6U3</accession>
    <name>A0A367L6U3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flavoprotein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_8600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L6U3"/>
    <dbReference type="STRING" id="1330021.A0A367L6U3"/>
    <dbReference type="OrthoDB" id="70387at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071513">
        <property type="term" value="C:phosphopantothenoylcysteine decarboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359:SF21">
        <property type="entry name" value="FLAVOPROTEIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359">
        <property type="entry name" value="HOMO-OLIGOMERIC FLAVIN CONTAINING CYS DECARBOXYLASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140860">
        <property type="entry name" value="Pseudo ankyrin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="2">
        <location>
            <begin position="28"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI10129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="590" mass="67437" checksum="F77024B815D2AEEB" modified="2018-11-07" version="1">MAYFPSYASRLSSSTSLNDMRSQHRRLHLLVAATGPRDTSWAQALVVRLSKSPEIEARAIVDDVVPRLTQTIIVMENRNLVLGQGERADDIDFYRQQAYELVEWADLMVCVPLDADGIAKMLAGIADTLLGAVLRGWKPHKSVVLVPGMSTHMWTNPTTKRQLSKLHRKWSWVRVMTPILWHYEGTPTPKRVPNWNGFNEVLGLIKNQADLLSLGRDVEVATDSATVLNAGVGSSTKVKAKLPPEIWTVVLDFAGDWEMAKALGIYTNLPMPQPWRLEPKDASDALQVYEHELEWTVLTCSSAAICKKLSQSPPNFKDLPALVVKLVIRFALIQVLEYMEINRPELFRAFDGTTLPTNASAYYPRTDVLDYWKQSMWFRDKHVYDAEAVDGASKNGHVRVLDWWWRRSGLPLRYTETALEQASGQGHLLVLEWWRDAAAQDESIVLRPGRSLLWATQHGQAEVLRWWDASGIPVAHGDSVAKVASRWGRVEVLETWRRLKGDGKLIFDTEVLISSTMHQHVDVLEWWRQFAHGELEGMDGRKQPVEFRTCNIEEALEDGIGDQRKARRWWTQYGLDLRMRNQEWLQTRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L6Y8</accession>
    <name>A0A367L6Y8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_8655</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367L6Y8"/>
    <dbReference type="OrthoDB" id="5370537at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125:SF12">
        <property type="entry name" value="AT HOOK TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125">
        <property type="entry name" value="LP07818P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="191"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="966"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1055"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1168"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1266"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1339"/>
            <end position="1532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="627"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="666"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="697"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="734"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="807"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="841"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
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            <begin position="1055"/>
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        </location>
    </feature>
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            <begin position="1072"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1126"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1189"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1272"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1289"/>
            <end position="1298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1302"/>
            <end position="1314"/>
        </location>
    </feature>
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        <location>
            <begin position="1352"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1368"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1394"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1494"/>
            <end position="1511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI10196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1532" mass="164299" checksum="3CB34CE2EAD5D8CA" modified="2018-11-07" version="1">MDCCAYYRRRTVRPGRPDHWLPSCTSLSSFLGPPAIDTTYTFNLEASRSKLQDPSLIVCLLIWSAGLLMALATMAFLPLLSLVMANLDNGQAVAAAIFFALVVVAAVVTILLYLREVHTPLYRDGPRLVLVGYLVASLAWALVGFIAIVAINGDISGCQVAVTLFAIFDQLARFLLEQFIFWAIKSDAKISLALAMSQAVFAVRFILGAVFVGVQRPQVKPVCVTKTAVLALAIVVLIADAVVVILLLCRAYSAGSLRDLPEKTLSGSRSRALLLLVVGLVVWTALSVPMILGDETIALAVRTVLPAIGSLFVIGLLAALRRSLRSNQPDPSPSTGYLNGPFSRELPSRDISTAQSAKVFSNDASSSDQSMPKKGKNGLPYISQPMPQAQSLSAKSFEAPRSNKTLGLRGGRLHISNPIVQTEGDLAFVARMPTIDLATAAKNEKERREQYLRASTAASSSNPIMPEAPLPDGMRGNAQDVERKELVPTGQDADQSPDSSRGDTSSAQPSPSAGTMRRRSPGGDSEGSVDGWPLTAISAMNFLEAPRPAPPSPKQSTADTPRPSFQESLRRSLTESEVYTDSNPPPSIPRKFSYPRETVDVLVSSARPLSPMKSRKPDPVLPKATMSIKSPSSSASSRQVLQSPESPASSARAPTSPSPRTVSSNVPPPSSTPPKSPPPPMPKPKQPTRKSALSGPPSLPPPVPQPAPPPAPPPTHGASNDTDRSRAALVALSRNGSAKSTIRPSRKLASPPPVSPVKDKTKAPVLLRSMNGIPSNPRAKKLAGGPLKSKDASSVSAGASRFPTDRVQSSVSSNSSVSAKSGGSVVNRPRPVPRKKRVEDIVVDDELQESDEAETSPEEDEKQAGPSVTGNVKRPVPTQTATSGDASARASEESRRADGSSLSRNRYADSTLLTDEDDGKEIVMVMLDQSAEHENKIDGQQISMQRKTVSWHRRVGEECPTFSDRRATRSKLLSKPPPLPLGAPVKPVIAAAPELPPPESPTQALDKIEEQLKRLENVGLSTEQQRLNPIIEDEKEDDERGLNLLADIELEMGRQEDRWQEMRRDYPQTPNSTSSSTLDLDTPSPKDTRLAELVNDVAYAGLHHGDDAGEDMSLAERDDSTDRMFLSQLPSAPLASLEDEEVTAQSLDSESWPLESHDYYGIDNSLEPVMEEDLDVSQAPVASRGSSRPQPPVVRPPTIRPPRRTKRITALPDIVENPEPLADDKDSLGIFQFPWGERSDSASVPFQGQMQATAMPFALPTYPPLLGDDPVQAQDYSSSFFDDYDEEAAASVSSSDSSSDYDRDDEDDEGDDVDGGGGGDSFDETTLWEIASLLKSDKVPSRASLFPDEIDSMSTSTGQPSSMEAFPVVLDGGVGSSSSMQSSLSHLWVDKAAQQQQQQQQQQQQHQQQQQQQQQQLTIVGLPQPEEEEWQTNYVLPADMGAEPKKTRSTTLPKPSEIESSGGLWPPPANGPSSLGHDWISVSSSSMRSGTPGGASSSSSRQSPVSDSASPKSGLTGPSTGGSVLPSDAKPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L726</accession>
    <name>A0A367L726_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8721</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="200" mass="19345" checksum="3EB110A1966297F0" modified="2018-11-07" version="1">MSSDIAVRCGGMIAAAADERYRGLAAIKASPAAAINTSLAAAAAAINTSPSAAAAAINTSPAFPAAAINICAATSGIAGRQEGVSRYTSRGEASSAYAAASLAPASISTNAFLAASHAAGVIEAAAIGPCRQALSTTIAAALVPLASFKAAAAASASEATAASGAAKEEETAEGLQPRLGRPALDAFSQGTPATTRNQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L786</accession>
    <name>A0A367L786_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8457</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="STRING" id="1330021.A0A367L786"/>
    <dbReference type="OrthoDB" id="4463286at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="436" mass="46489" checksum="745C4C126FDC066E" modified="2018-11-07" version="1">MSAAVAMAPSPAPHERQSFSSDLRPTPMAAQQSPSSGQKTPATLSGPGNGSTPRRVANSPKAPKSSPSTAPRSDPKPPKIVVKKEPGSPTLSTTRPRPRKLDLSKSTGSSSNMPASAVPLSARDNLGIQEVGIACLSPGFVTQDPVMKEQLQRSMTVREQQRHIIEARLQQQSAKGDGPADKDGSQQFAAKTPGMSRRNKAPPGLSIVAPSHEQFADERVIQSAPLGHSFSGRQHLASLSRHVVNQPSHLSSTSQIHHVPATQTNNRLPPLSDVFGQSVSAHPDNAPSSLYPGNPSRGPLKSPSHPPPPPPPPPPPQQQIPTSGRPREFKSAEEAQHELAGGRPELLPKIVHYGGHQPPTPPSPAPGSRQPEGSRSASKRRTRTEYEEGTSPPLGHGPAATRRGPFGEGRDSPDAQRQKKDEFLRLCARAWDLFHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7Q1</accession>
    <name>A0A367L7Q1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">LSM complex subunit LSM4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LSM4</name>
        <name evidence="12" type="ORF">L249_4279</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7Q1"/>
    <dbReference type="STRING" id="1330021.A0A367L7Q1"/>
    <dbReference type="OrthoDB" id="747253at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="project" value="UniProtKB-UniRule"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="InterPro"/>
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    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
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        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm4"/>
        <property type="match status" value="1"/>
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            <begin position="39"/>
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            <position position="162"/>
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        </source>
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        <source>
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        <source>
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        <source>
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        </source>
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        </source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="RCI10449.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="162" mass="17700" checksum="78B001642F30ADFC" modified="2018-11-07" version="1" fragment="single">SIIQHPHSHLLLDPPTSWSVHRNTNPKRKTLTSTHTTQLPLGLLNAAQGQPMLVELKNGETLNGHLVACDTWMNLTLRDVVQTSPEGDKFLKLKEAYVKGNNIKYLRVPDEIMELVSESQKAHPSGFRGGRGGQSRGDHGGRGGDRGRSRGGGRGRGRGRGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8M2</accession>
    <name>A0A367L8M2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="77"/>
            <end position="118"/>
        </location>
    </feature>
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            <begin position="83"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="118" mass="13296" checksum="0570D5D6D85E35D1" modified="2018-11-07" version="1">MTVFAGFVGPVVIMGSWPEGAASRFPSFLSLAVDAIEFLQSNASLPAAYRLGFNRRQIRLVPSPWFPSVEKNKASHGVVRKKSYADSDREQLSKGGRRRTKVKFMRRDEEVEKASRLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8P0</accession>
    <name>A0A367L8P0_9HYPO</name>
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        <recommendedName>
            <fullName evidence="8">FMP27 GFWDK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_5280</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
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        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367L8P0"/>
    <dbReference type="OrthoDB" id="1562405at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019441">
        <property type="entry name" value="FMP27/BLTP2/Hobbit_GFWDK_RBG"/>
    </dbReference>
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        <property type="entry name" value="FMP27_SW_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019449">
        <property type="entry name" value="FMP27_WPPW_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045167">
        <property type="entry name" value="Hobbit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678">
        <property type="entry name" value="ANTIGEN MLAA-22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678:SF6">
        <property type="entry name" value="BRIDGE-LIKE LIPID TRANSFER PROTEIN FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10344">
        <property type="entry name" value="Hobbit"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01214">
        <property type="entry name" value="Fmp27_GFWDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01215">
        <property type="entry name" value="Fmp27_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01216">
        <property type="entry name" value="Fmp27_WPPW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27 SW motif-containing RBG unit" evidence="4">
        <location>
            <begin position="1185"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27/BLTP2/Hobbit GFWDK motif-containing RBG unit" evidence="3">
        <location>
            <begin position="1305"/>
            <end position="1466"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27 WPPW motif-containing RBG unit" evidence="5">
        <location>
            <begin position="1723"/>
            <end position="2178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="732"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="866"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1101"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1965"/>
            <end position="2033"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2433"/>
            <end position="2454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2513"/>
            <end position="2578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2714"/>
            <end position="2842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="751"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="873"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1107"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1127"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1973"/>
            <end position="2017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="2531"/>
            <end position="2550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2553"/>
            <end position="2567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="2744"/>
            <end position="2764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2777"/>
            <end position="2786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2810"/>
            <end position="2825"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI10784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2842" mass="313345" checksum="872F1F058635830E" modified="2018-11-07" version="1">MFCEATARLSSALLMFAALLSETAFAGPLLALGATAMALLNPTFFLGLIVLLYLSSFVLFAVIRIVTGVSIQRIGYLSLRRLAYTPRDGLVIEIRGLGLNVHRPTFAQPTWVSLVLNELVVTVDASEQKPTKAGVDRGRTPDKKSRAPHTQSASASSSPASNIWSKAAKFRQAIKKLHRHIGWLHMIDVVASHTTVNVVGVGHIQLGSLTLAVDTRRRRVGHSQKLHLGDEKKRQAEWIVTLRSLLFTADGGESLEVLDHALFNVHGFLHESRDGLRDVTIAIKLGRVSVPYDDVMLCAAKLRTPTSTTTTTTTTTTDFVVPQTDPTTPPAGDDNDHKSGDGQDNEELMQTVTDSREFFSAILRNIKEVQFAVSFAGLTKKVTSIKPSANPILLNASMKEVGIDFHRLDPKSPAHRMYFSPKDIAHEALAAALSISIDLDDGQRGPERIVYVPMATTTARTTLPSKTVQLAQESALEERNANILFANSVVTSPSVDLDPCHLPLLIALLQPKPRPPKAHHGGRQQLISHLLPKANIKLSMHEPVVRIRLKPLQRTADPDDFDLIISSISSVSLDAESSHSPVEDLHYFLDGSIRLQSHSLYYQTCAGEIFNLITTDSLDIKTHLAATPDVCVDITGNIQSFSISMARQEITDGLRQIVRQLRIDVEPDKRAASKSPNRQNFLRAVPEWLTSYHFEASDFNVEVAGVDEDIADDTRGVSLHLDSFSAEYRAHKLDEPQRRLGGGRRRAHSRLVNQSDSDMAPSTPTSPRLRNKKPQTAGDGRRLVLQARGLEAHIVEAADQLEIEPFLRMPRLELVLSAASDNLGPMFHVQATVRTILVQYSLYRHYAVGVAVMTLRKALMRTGRDLPRPRQLGTYSNPDACPTSPSVPAGTASSTVVSELVTVDVRASLLQVKANMPNDPAMMLHVYGVEAGRHRWSTPYLATKLVRLFVEPPRMRNVWARLLSVHSGRVDLRESRHKTALGGYAEEKMFDVATEAVRLAVPHEVVVDRVTDNVINTLKAVQQLHHRFKTGTNEYILEKKPESAKLLPKTSIRSRNVLLELEDGAFEWKLGIIYRTGRAEQAQRLVREEAFRVKANKVREEASVRKGSNVRSRSVMSRGRGSGAAAGAGAQPSSSSSSAAAPAGSWFRSRSVDGRPDTPRTSLPRYDPDGDSLHVPGQAKVSEDEARTFLDAYNAQAWQKRIDRAYEASRTAACEMRESFWGDSQMPEDLEVTEKILEVPPRPALMAAVLSDFHAVVDKPSFAMRDLPGFIHKVGKGMPLDMRYGLLLPMNLTMGMGEVRVSLRDYPLPILHIPSLKPGQSMRAQSLTLKGNLVVAEEFQGVESQRRVRVNVIPARDPGSGASANEGSFAIEVIRTVSAVKSYSDLYMDINTALPTRITWGPSYQPAVQDMMMVVESFTKPQLDPSELVGFWDKLRLNTHSHLHVAWKGDGDMHLSLKGTRDPYQVTGNGAGFLMCWRGDVRWNINVEEDPKRFMTVDSGEYILAVPDYSHLVREAARAGGGGGGGDLVDGGSSGVGVGVGVIKAGAIFKKVAMKLSGKVQWMAGLVFERAIVDGKRNFHSKPHYEVVLKNPLYAKPDHGLPYDAFRGFRSRHIHLSIGVRAPADRQWTPDRPEPSGSYNSVHLTPRVFTHFFEWWGLFSGPMSLPIRQGALFPGQEKNSKKFGRHLATVKYSLLLAPLFLSHIYKHKEAAEDHSESAVSTTGLKVRFENFMLDLHQRREEFNAPGKSKGKKDTPSRISGIKVHEGQLDLAKADVRAVSASLKGTTTEAIRNGTMGPLMADQDEKPDLSRFKIPDHDTSWIDMDDFVELDWILPTEPNPETKILPLAFSPRLTYFRQTDICGTIAGDPTRTSPFGNEPTHFCYMTHDDDPKRVQARLIQGRLDQLEGQMLSHSRNVGEAELKAWNNVLRNIVLRYIHQVSQRRGFVYYLSRPAVKFLLDIVEEQHKGRTQQRPASPTGTSSPSQTGAESVAETGGTTASASAAAAAATTTSTAPTVANQPPVTAAAAEREEANDLEERIRRMISDGRGNWRANGDGSCSAICDLESGISRDYTPQHGYHVRLIGPQIQLQSERNKGNVVLVTAKGMELKVLEVMDRERISDPVSGLVQRRMLLNMDSTQFFVARRQWFSSSTVSMYAGSRYGTPKGSMWPPWAPMEIMFNFAADCVGFKRVVRKTSAMLRYDKFNNLRLNSSLSSSSPPADSGESLRSDSLWVDFPQVRAICNSSEYYAIYVIVLDLLMYSEPLEKTRSERLEKIMLASDFSDLSGAPLMVQRLQSRIKQMEEIKNQFQVYSKHLDRRGWEDRLTLERDLASSEDELFFVMKAITTAQQKHEANSDTKALLKWIISGRDIVWHLIQDSNEPLVELQLRDVEYDRTDNADGSHTNLVRVGKVLGLNLLPDATYPEMIGPYHSVGDEKGSSYRGRSRHGRGGGGGADDWHKRDMIRVYWHMLEAIAGITVMDGFEVSLYPTRLQLEREAGKRIFDYVFPGMGGDKASATGKNGGGTTTTTTTYEDDDGGGHDDDDADMDDVGESPASSSGRLDNNNHATMTGADVNGGGGFSTKAGSLELRLRPTLASHATHERASKKAWGGATMLAKKSSYDSLRSTGPVGKTAGRSSSRNFEDVHDFVFRMPTMEWQNKTWSNLDLALALKKAVMKVLISHTGAIIGNKFSKKRPNAEQRVRLRELANSSVVISSNSGGGVPASLAMTPMDGHEGEGGGGIGGGEEEEEEEGEGEGKEEDDDEGEGKAPSSSSHGQQHQHQHHRWRAGSSARQSDGRPETRAGGSGGQQEAERKKGTTGGLRERISALTHRRGHREGGGGKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9C2</accession>
    <name>A0A367L9C2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5258</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI11019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9C2"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI11019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="189" mass="21322" checksum="C41AE4E87456CAAB" modified="2018-11-07" version="1">MMMSLFRSRCLTSHRAANPRGDYPCGRFPRHEGGESPSIAIKRSGIDADILYLSGWNSNGIRPILANGPPESRGKCLCRYRSLSLYADDERYTNESYSYTGIRNIMVPMFNLQGCLQPGGMRRLQQTMSIRSRSRLQQRTNNSIKKIPNSQSSSLYRCVNAPLQTMPRISSPPFLKALSDFHDAESPNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L9D7</accession>
    <name>A0A367L9D7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein disulfide-isomerase</fullName>
            <ecNumber evidence="3">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_5186</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI11037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L9D7"/>
    <dbReference type="STRING" id="1330021.A0A367L9D7"/>
    <dbReference type="OrthoDB" id="10264505at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03002">
        <property type="entry name" value="PDI_a_MPD1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057305">
        <property type="entry name" value="Thioredox_PDIA6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815:SF3">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24541">
        <property type="entry name" value="Thioredox_PDIA6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017000715" description="protein disulfide-isomerase" evidence="8">
        <location>
            <begin position="18"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="9">
        <location>
            <begin position="6"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="245"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="435"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="262"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="445"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI11037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="489" mass="53434" checksum="FD4A39A9259A8923" modified="2018-11-07" version="1">MHTAAAVVAALLPAVQAMYPKSSPVLQVDAGSYNRLIARSNYTSLVEFYAPWCGHCQNLKPAYEKAAKNLDGLAKVAAIDCDADTNKEFCASMGVQGFPTLKTVRPSIKRGGKPVVEDYQGQRTAGAMVQAVVDKINNHVTRLTDDNLEAFLAGDKPKAVLFTDKGTTSALLRSIAIDYLDQVSVGQVRDREKATVEKYGIDKFPTFVLIPGKAASSDDAEKEEAPIKFELELNKKNLVEFLSKVAQPNPDPAPMDSKKKKSKDDKKKKDSKETKDSKDSTSGDKAADAKEPSAETTTGKETAKPAMEIVSITAIKEKDVLVQKCLQPKAYTCVLALIPSDASGPGDKVVASLSQLNSKYLHGKRHLFPFFSVASDVDGTTALRDALKLGSGVELVVVNARRGWWRRFEGDDFGVESVERWIDAIRMGEGKKKTLPEGVVVEAPAAEKEETKEAPKEESKEAGTDKKEKEKKEKKEEEENESKVKHEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LA07</accession>
    <name>A0A367LA07_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_7533</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LA07"/>
    <dbReference type="STRING" id="1330021.A0A367LA07"/>
    <dbReference type="OrthoDB" id="1913277at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039205">
        <property type="entry name" value="NDUFA11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21382:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21382">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI11246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="204" mass="22066" checksum="697AC162BEB9E3F5" modified="2018-11-07" version="1">MPDRADAETHFVPHDVIGVTTKTAFVGGVAGLFIASIRNALARENVGALSVFTRGRGIIGMAAAGPAAFAFVYTATSNLRQKTDTLAVTLGGFVGGSVIGLPLIYLVARSFPTVLGCGAFVAVLQGGFFFLGNRLDSFYDEDDEFERKEIIRRTTRIPVQQTIAEVGEGRGIKPPGYEERRRQRIKEKYGWDINPVPVTVDGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LA19</accession>
    <name>A0A367LA19_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7225</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LA19"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI11271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="92" mass="10278" checksum="D487A08DD914B98D" modified="2018-11-07" version="1" fragment="single">MIIRRLQPKMEQKCAYYEKPVYSSAWFPNLLRRTVTSEIFGVDATVDLLWIAQPTTSFICEVNKSLGPTGRLVSSQATGNYGKNGEVAHLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LA76</accession>
    <name>A0A367LA76_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_7770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LA76"/>
    <dbReference type="OrthoDB" id="5214669at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI11316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="161" mass="17655" checksum="A17D347B1F812C54" modified="2018-11-07" version="1">MPLADSTDQDPQKAGIQVQTTIATLEKAALPTTTVTAYPNSFERSLCPSGHTSPGTDRSQNPFDTDVEAMMTNGSTDKHPRPSVVLNRQNDAQVWPGKDHWKQRAKAAKRQRSCTYMSRLDRRTRIAVKILVIVLVIGIGFAVGFGISKPLNAPIWGKNTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAV0</accession>
    <name>A0A367LAV0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_7738</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-lysyl-[histone] + acetyl-CoA = N(6)-acetyl-L-lysyl-[histone] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21992"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:21993"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="2"/>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAV0"/>
    <dbReference type="STRING" id="1330021.A0A367LAV0"/>
    <dbReference type="OrthoDB" id="3361892at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032931">
        <property type="term" value="F:histone H3K56 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051236">
        <property type="entry name" value="HAT_RTT109-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013178">
        <property type="entry name" value="Histone_AcTrfase_Rtt109/CBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016849">
        <property type="entry name" value="Rtt109"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31571:SF2">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE RTT109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08214">
        <property type="entry name" value="HAT_KAT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01250">
        <property type="entry name" value="KAT11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51728">
        <property type="entry name" value="RTT109_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="308"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="446"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="359"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI11543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="483" mass="54432" checksum="CBD86E91E161BDDE" modified="2018-11-07" version="1">MAATKPAAEPSGLLCRLAAVLPKNHQFVVYHLSTPPVKTDALCSAPPNERPDRTYCEKHFLAVSVAAPNPVLVLGLEIFIYTTAHATTLFVSKADSTGCLSLLDLPSKGPSPIREICTAFIAYLVENRRRSAIQLIVSLFARSQDQYLFPGSVKQAGKHVLDDRGLVKWWCRVLDPLLDCAKWTRVQGYLVVPGLEPAETRVFLPRTRAGSDWQIGHPLERISHYWREFDWVPPRCLIPRFPDDPKSRFRDELDEEAANSGIMRNLGSWKSVRTLDTFWEVMGFRQECSSGRMTGFIWVVFDDADHNNNNNNNNNNADPRTPEPEPDGLPKTTPKKLPQSQGDGAPADEPHQGKDEKKKKWRKKRLKGQIKPRQPRIKTSQRNYLADMPSSSKYYSWPPQGRGEHVVDEAVYKRIVDHLLHLDFATPDKAAGSSKRWIGEAGMGRPWGLEVTGQREPAASAASHDERKPEQINNLSGLVKRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LB34</accession>
    <name>A0A367LB34_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial import protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7654</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LB34"/>
    <dbReference type="STRING" id="1330021.A0A367LB34"/>
    <dbReference type="OrthoDB" id="5529571at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070096">
        <property type="term" value="P:mitochondrial outer membrane translocase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013262">
        <property type="entry name" value="OMP_MIM1/TOM13_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28241">
        <property type="entry name" value="MITOCHONDRIAL IMPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28241:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08219">
        <property type="entry name" value="TOM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="14296" checksum="ABC1D18B9A28D52C" modified="2018-11-07" version="1">MASDEAPASQSQHPLAESGVTMHSDSEQYSPGGEDLSTSPPSSGEPVILYRPPTMWSLVRGAAINLVLPFINGMMLGFGELFAHEAAFRLGWGGTKVFPLSRRRAHPIGPGIEVRERPPRPPGVSLDDYASLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCI5</accession>
    <name>A0A367LCI5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_0570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCI5"/>
    <dbReference type="STRING" id="1330021.A0A367LCI5"/>
    <dbReference type="OrthoDB" id="4917004at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016975409" evidence="2">
        <location>
            <begin position="20"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI12133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="835" mass="91640" checksum="483E86C5A6773F77" modified="2018-11-07" version="1">MNSTALSILLLSFFSPVSARASSGSYDLRQQPPTEEEAHRLPPPDTGPKPEPARPPPYFHHLPPPTWRMEAGAETANEDHRRNVNRASRRKENCIRSRIATATTKPGTGAEVEIKPKRVKGARPKVEAAAETTALQAKDQKQAPKPLTALAKDIADKEFSDMARKAGHAAVVERRWGKSLPEIRSMALSYLGLSPTSPKSAALRVQSTGLTAIGYVVWIEQMVVAFTTETSRLEKAVAVTMIIPFVGCGVSTYAKVEKKGRLGEMLVIDASLCLLGDVLLLGGTTAPAGIIVHIVRFLIQVFEPPPRLPSLQEIVAMRDRPWHVFLDHHLTGFLCSKTWRDKLEGAIAIEALAIWSEAADVVGLLEASRHFVLNESLPTVRKRAEQDEKPRPDPGAAIVEVRNRAAAEVLRRHRQNLLDLPGLLRDSFAASIKATAEHYNREFMRKLVSDETVRKYPSEAPIAAWTRGDALYEPANQYFLAAARHLWDRPPRLPSLFTLAYFVGVSAGVDDPPPARVVHGDMPGFAKYAAAEKEEWTSAVDAAVIDPVGYYRQKTGKGGLDQGWAVLARHTLAVVRHLQGKMPESHLPQDAPQGLSDVREFQMLLAMHVGRTFADWKEARGSDVGYVHEDFEKDEAGLINRLYPDTRLEVKRLIDANSSMAIPYSAPSAGCRDALKLLAMAIGTDKTDAGGPVISLSVRPTTGTCPQIQGLTSRPVRRSGQWPVCRYGTLPPTKPVVRKWWTELVRSMPSAYSKIRRGGLDLDVLKGCHDLREAFISGRVAGVNVDEAGWYALDLYGSGPLSLRWCRDSRASAGSGRGNWYCTAKSLTDDLPGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDD4</accession>
    <name>A0A367LDD4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyl transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_0183</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDD4"/>
    <dbReference type="STRING" id="1330021.A0A367LDD4"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901135">
        <property type="term" value="P:carbohydrate derivative metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46830:SF2">
        <property type="entry name" value="ALPHA-1,4-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46830">
        <property type="entry name" value="TRANSFERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI12421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="44189" checksum="13BC0EFB7DDBD0AB" modified="2018-11-07" version="1">MAFHCTRRKFRLFVVAKVLLFIGFLGGYLDEDFRSNVIRAAGPTWFYLSGLTRYDFRPTLEEQACLNGSAVRINAPGMTPGIPKMVHFVTGVDRPNPITFINWLAIRAAAANLGPDVEIRLHYVHLSEEGPWWPDVRERVRLVKHRPTFLNPFSHIMPPPAEWHPAHKADILRLQILLEHGGIYLDGDVILLRSLDALLAGRRDVVMGYEGGHRKGSCNAVILAKKGAPFLQRWYRLYDDFDPTDWNYHSVQLPAKLAAAYPHDICPLSPTAFFWPLWTNDQVAWMHKPLNRQEAAGVAAAIKRNGGALFPGQLAYHATGAGSHMGASTTQELLARDTRFNMLEGHGRKRICELHKPRPCLPTVQEDTVDMRRFWDQMVVLSTDQFIRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDM7</accession>
    <name>A0A367LDM7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Cysteine synthase 2</fullName>
            <ecNumber evidence="4">2.5.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Cysteine synthase-like protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">O-acetylserine (thiol)-lyase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">O-acetylserine sulfhydrylase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L249_1300</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion outer membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="4"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDM7"/>
    <dbReference type="STRING" id="1330021.A0A367LDM7"/>
    <dbReference type="OrthoDB" id="10259545at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000096">
        <property type="entry name" value="Related to cysteine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="16">
        <location>
            <begin position="79"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00078263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00078545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00079149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCI12520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="434" mass="46508" checksum="4310416C72338BF6" modified="2018-11-07" version="1">MSLSQHPKAAYGTALVAAAAAAAAAFVAVVALGLTDRYLEVETRLQRKASRSLRRQSSFFSVRLEDRDPGADDAQGVEACIGNTPLLDITSLSEATGRTILAKAEFLNGAGNSPKDRVALSIIQDAERRGLLVPGRGDSIYEGSVGSTGISLAALARARGYRAHVCMPDDQGVEKSDLLRHLGATVERVPVEPISSEHHFVNLARRRAEEHAQKVRDGSRGFFADQFESDANWRAHFDTTGPEIFVQTGGGDLDAFVAGAGTAGTISGVARYLKLEAGLASLRVVIADPHGSGLYNKIKYGVMYSPTEREGTRRRQQVDSLVEGIGINRVTHNLDIGYHLIDDAVRVSDDQACRMARWLVSHDGLFVGSSSAVNCAAAVAVAMTLPPGSRVVTVLCDSGTRHLSKFWSRIKEMGLEDTETTDLFAELGMSQSQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDR4</accession>
    <name>A0A367LDR4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Lipoyl synthase, mitochondrial</fullName>
            <ecNumber evidence="10">2.8.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Lipoate synthase</fullName>
            <shortName evidence="10">LS</shortName>
            <shortName evidence="10">Lip-syn</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Lipoic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_0837</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine + 4 H(+) = [[Fe-S] cluster scaffold protein] + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 5'-deoxyadenosine + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="10">Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the radical SAM superfamily. Lipoyl synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="10"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDR4"/>
    <dbReference type="STRING" id="1330021.A0A367LDR4"/>
    <dbReference type="OrthoDB" id="3231at2759"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016992">
        <property type="term" value="F:lipoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000036">
        <property type="entry name" value="Lipoyl synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031691">
        <property type="entry name" value="LIAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00510">
        <property type="entry name" value="lipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004019">
        <property type="entry name" value="PRK05481.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009544">
        <property type="entry name" value="PRK12928.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="LIPOYL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949:SF0">
        <property type="entry name" value="LIPOYL SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16881">
        <property type="entry name" value="LIAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00271">
        <property type="entry name" value="lipoyl_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01058">
        <property type="entry name" value="lipoyl_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="11">
        <location>
            <begin position="144"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI12556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="421" mass="46017" checksum="4545EAD6CE80EE92" modified="2018-11-07" version="1">MAASSIRCASSIRCASSTPVHRAPAVIFRSFATVPETDDGAAAQQRPRRKTYFKDRTVAPFSDFLASSSAAASELPPSDAYELRTAEVGPEGRRRTITRLPEWLKTPIANGSNFKKIKSDLRGLGLHTVCEEARCPNISECWGGSDKSAATATIMLMGDTCTRGCRFCSVKTSRAPPPLDPHEPEHTAEALARWGLGYVVLTSVDRDDLPDGGAAHFAETIRKIKMKKPSLLVEALTGDFAGNLDMVRLVADSGLDVYAHNVETVEGLTPYVRDRRATFRQSLDVLRHVKEVRGDQGIITKTSIMLGLGEQEAEVTETLQELRKAGVDVVTFGQYMRPTKRHLKVERYVTPAEFEIWRQRALDMGFLYCASGPLVRSSYKAGEAFIENVLRKRAVSKVSPNAGEGLTDAVLLGSGVDLPGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LE83</accession>
    <name>A0A367LE83_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0297</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LE83"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="295" mass="33352" checksum="55AB6E32D8CB4C62" modified="2018-11-07" version="1" fragment="single">GTGYRHRQGITRRWASVWQEPGGRFGTRLRRRPVGVVVDGHLSVVSSLSGHVIVRKVCTYTAVKSRVYFWFQPHFLFGCGGAELNLLSSSRNRRGGRKNTKKLKNLLPRIQEIKSAYSVIVGASQNCFDSMSDSRGRTVPDAGTRPFPSPFSFFMIKAPLWQFFLFFFGLTFWILGVLNLLVRERAGEDGLLVWDSQSSVESSRRSCIPEVHIYLSAGRVHEDAANKTALVPWVLEKGDHRLCQRFRRADKTPASSHRRRLGFGSEGIPDASLWRRSGLSAHPTDEAKEKRKECC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEA6</accession>
    <name>A0A367LEA6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RNA polymerase II subunit A C-terminal domain phosphatase SSU72</fullName>
            <shortName evidence="10">CTD phosphatase SSU72</shortName>
            <ecNumber evidence="10">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_1278</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. SSU72 is required for 3'-end formation of snoRNAs.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Processively dephosphorylates Ser-5 of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Component of the cleavage and polyadenylation factor (CPF) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the SSU72 phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="10"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEA6"/>
    <dbReference type="STRING" id="1330021.A0A367LEA6"/>
    <dbReference type="OrthoDB" id="57957at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000039">
        <property type="entry name" value="RNA polymerase II subunit A C-terminal domain phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000189">
        <property type="entry name" value="SSU72p Phosphatase and transcription/RNA-processing factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006811">
        <property type="entry name" value="RNA_pol_II_suA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20383">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04722">
        <property type="entry name" value="Ssu72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI12746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="248" mass="27841" checksum="DCF62DC35F7C3ED3" modified="2018-11-07" version="1">MEAVNGSVPNGSEETQGPFKLKFCTVCASNQNRSMEAHLRLSQANYPVISFGTGSLVRLPGPTITQPNVYQFNKTSYDSMYKELEAKDPRLYRNNGILNMLDRNREVKWGPERWQDWAVGLPRLQHAKDRGFEGTEGGVVDVVFTCEERCWDAVVDDLLNRGSPLNRPVHVINVDIKDNHEEAHVGGQGILDLANSLNAAAVEEREAMGSATFDSGNRASFDERVPEIIGAWQERWPHLPATWTLAWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEF2</accession>
    <name>A0A367LEF2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_0893</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEF2"/>
    <dbReference type="OrthoDB" id="3691706at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI12805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="65" mass="7809" checksum="F8C5297AC79506DA" modified="2018-11-07" version="1">MRRLRLYLYRVSYIFLFDFTVQYISGKKNLIADALSRKPTIDIDQIKRKKDSDSKDFVDLYLNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LF75</accession>
    <name>A0A367LF75_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GPI-anchored wall transfer protein</fullName>
            <ecNumber evidence="9">2.3.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_0195</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">A acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Endoplasmic reticulum membrane</location>
            <topology evidence="2 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the PIGW family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.-.-" evidence="9"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LF75"/>
    <dbReference type="STRING" id="1330021.A0A367LF75"/>
    <dbReference type="OrthoDB" id="15270at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032216">
        <property type="term" value="F:glucosaminyl-phosphatidylinositol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009447">
        <property type="entry name" value="PIGW/GWT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06423">
        <property type="entry name" value="GWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017321">
        <property type="entry name" value="GWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 9" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="402"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="447"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="481"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU280819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI13078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="506" mass="54525" checksum="65BD5E50E914E023" modified="2018-11-07" version="1">MASYKQRKEAFVSNLSGGSVAEVGLVTSVAPARGWATAADVFFSLPNQVAVLLWSVLQARHSFFRPYTTLGLAVDYALNAGAILLATTVYAGTPVLLDGLLIAPAVLVYVMSVNNASSRRKKARVPPPPAEQQQQQQQQSKARLDTLPLKPFLTTYRGCMMVVTCVAILAVDFHLFPRRFAKVETWGTSLMDMGVGSFVFAGGVVAARPVLAERMAGRTTPLLRRLAYSARHSVPLLALGGVRLASVKGLDYAEHVSEYGVHWNFFFTLGCLAPLVAVFHSALSIVPSYAALALLVAGLYQVLLDRTALAAYILSAPRTGLISMNREGIFSFLGYLAIFLAGQDTGMAVIPRDATRRPPLKATAVRGLAWSGLYWLCTSYSYGFGLGVSRRLANLPYVTWVAAFNSLQLLAFCCIDAVFFPAFYSAVDGKAEMEAYKAATSWVLRAYNRNGLAIFLAANLLTGLVNLTVRTLDAGPFKTMGVLLAYTATVTGLAVGLDAYNISIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFC0</accession>
    <name>A0A367LFC0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Uracil-DNA glycosylase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_1289</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFC0"/>
    <dbReference type="STRING" id="1330021.A0A367LFC0"/>
    <dbReference type="OrthoDB" id="10031947at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097510">
        <property type="term" value="P:base-excision repair, AP site formation via deaminated base removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.470.10:FF:000007">
        <property type="entry name" value="Uracil-DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003588">
        <property type="entry name" value="PRK05254.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003589">
        <property type="entry name" value="PRK05254.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003592">
        <property type="entry name" value="PRK05254.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00628">
        <property type="entry name" value="ung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264:SF0">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00987">
        <property type="entry name" value="UreE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="10">
        <location>
            <begin position="171"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="366"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI13123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="386" mass="42850" checksum="7D4E11F48DAC6EFA" modified="2018-11-07" version="1" fragment="single">AQLSSYTVEIFFFFPSVTSSAIELAVILSSIGCRIASAGRQLASRPRLGLDNMSMLKRKSGSSLPVEAEAKKLKVNGNIASFFEAPKPKPGTESSTTAVKFDKQAWIAGLSTEHRELLELEIETLDDSWLAHLKDEVTTKEFLELKRFLERETAAGKKWFPPKEDVYSWSRHTPFGNVKVVIVGQDPYHNDNQAHGMAFSVRPPTPAPPSLKNMYKALSKDYPSFVPPPNKGGLLIPWADRGVLMLNTCLTVRAHEANSHANRGWERFTQRVIDLVAQKRTRGVVFMAWGTPAGKRVQKVDKQRHLVLQSVHPSPLSAARGFFDCGHFKKANEWLVTRYGADGEIDWALMSGTTTKKSEIKADAPSDMDSDDEAALEEALKLAEAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LG49</accession>
    <name>A0A367LG49_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-lactamase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_1223</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-A beta-lactamase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LG49"/>
    <dbReference type="STRING" id="1330021.A0A367LG49"/>
    <dbReference type="OrthoDB" id="428260at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050789">
        <property type="entry name" value="Diverse_Enzym_Activities"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283:SF17">
        <property type="entry name" value="(LOVD), PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="23"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI13391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="401" mass="44316" checksum="D511F377CD71B719" modified="2018-11-07" version="1">MDKLDEILNSHVLAPSSTEQDTRDKLLGAAFIVVDQDGIVYKGAAGRCSLESGAPPFTVSSFTWLASLTKLVTTTCVMQLCERAVLDLDLDVVSLVPELGALKVLRGFDQGGEALLEEHSRTITLRQVILMLLTHTLGSPYVPMIPDLVKWSKRIGRPVRPTDWSIEGLTVPLIFPPGDSWVYGTSLDWAGLVLERVTGQSLGQYMESHIFRPLGMTDTGFWPEKLPQTASRTVAWTRRTPSQTLEPAENFTPAEHEIESGGAGLYSTADDYARFLRGLLQGKLVSEDSLRLMFSPQLTDGQKKAFNDMINQPDLHRAMASEFPLGLELDHSVAGVINLQHVPGKRRKGSLMWSGMLCSHWWIDRETGIAAVLIVNVQDAGDAVVERLYDELERAVYAGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LH54</accession>
    <name>A0A367LH54_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_8159</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LH54"/>
    <dbReference type="STRING" id="1330021.A0A367LH54"/>
    <dbReference type="OrthoDB" id="6159137at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="76"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="132"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="12"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="189"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="212"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="291"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI13717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="343" mass="39181" checksum="DC4E892456566CCA" modified="2018-11-07" version="1">MATTAMDYEAVGGDRYDDEPPRYDRDNRSASPRPIRDENDGGRRRSASPNGNVDGPSKDHSGMKDDDDDGAVNPGSNLFVTGIHPRLSEAEVSKMFEKYGDVEKCQIMRDPHTKESRGFGFVKMVTSEQAEAAREGLQGEQIEGRTLSIEKARRARPRTPTPGKYFGPPKRGKASRCMIEAVMATNDSAEPRGRFDDRRRGGYGGSASGYGGRDDYRYRGYDRGYGNDRRYDDRGYDRNYREERRYDDRGYGRDYDRGYDRRDRDDYYGRERHGGRDDRDRYSQRGNPSSYDRDRYDRQGERESTRARETAGSGYGDSGTRSDVREPYGGLICSDLPILKFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHN2</accession>
    <name>A0A367LHN2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_8148</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasmic vesicle membrane</location>
            <topology evidence="1 6">Peripheral membrane protein</topology>
            <orientation evidence="1 6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="6">Cytoplasmic face of coated pits and vesicles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the clathrin light chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHN2"/>
    <dbReference type="STRING" id="1330021.A0A367LHN2"/>
    <dbReference type="OrthoDB" id="5512at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000996">
        <property type="entry name" value="Clathrin_L-chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639:SF7">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01086">
        <property type="entry name" value="Clathrin_lg_ch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="133"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI13920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="238" mass="25901" checksum="6B87A3401728BD4B" modified="2018-11-07" version="1">MADRFPSLEDFDSGAQTDIKDPTDDIVGDDFLAREKAILGADADQFATVEDATAFAEPGGDLLGDVTAAQSSFESQFPDLTSPSAGVVGGLPGVSSVTGPSVSYNSGYQTYVEEEEEPQVIKEWRERRNEQIAKRAEQFAAQREETIKEAQQNIDDFYENYNTKKEKGITQTRKDAEQFLANQEDTVSGGTSWDRIAKLVDVSGKGMKGGAAGSGKERFREMLTSLRKDEKAPGATGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHX6</accession>
    <name>A0A367LHX6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHX6"/>
    <dbReference type="OrthoDB" id="5409477at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="200"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="252" mass="27918" checksum="904B67594581C11A" modified="2018-11-07" version="1">MDPNCAICSAPATLACDCEAKGLELAVRQAEDRMMRSIYSDIRAHAQDYVLEYFRLLAERRKTAHTVHLDQMAAHAFYHYNAPPHPNQIADAQAALKRGIDEDWQASVQRYPEVLEYYFGLVELTLPADDEQAVKDPPLSALNGHHHRKAARRSINTTNNNNNNNSSSSSSNNNNNNNNNNNPPAPPPPPPPPLPEAVVSSSSGSNPSSQTSPFAPLLPPDRDMPMERRAALPLRRDRRARIPATSSYAHFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LI04</accession>
    <name>A0A367LI04_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Plasma membrane channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_8052</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI14066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LI04"/>
    <dbReference type="OrthoDB" id="296386at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049456">
        <property type="entry name" value="Anoctamin_N_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF73">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20877">
        <property type="entry name" value="Anoctamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="320"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="533"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="583"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="627"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin alpha-beta plait" evidence="7">
        <location>
            <begin position="14"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="6">
        <location>
            <begin position="169"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="6">
        <location>
            <begin position="535"/>
            <end position="665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI14066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="757" mass="85606" checksum="56859B6FD59B9519" modified="2018-11-07" version="1">MASLKIGSDQHNLGVDYVILFKVPPQGRAHAEAAFVQAIEALSRVGLSTTVRRGGDSDSLLIFVRAASARRLGQQVRRSRMQDWLHGVRTAGTEADAARALEEDPVTEAERLRIVHQLITQPVNEGGAGVATSSFVQSVFPLRDQAFNRAWIQEWSQKQLLEQRDIDEIRNKFGESVALYFAFLRSYSTFIVFPAALGFSAWLLLGQFSYTYALGCGLWSVVFIEYWKKKEVDLAVQWGVRGVSSIQHQRPGFKWEFETEDLVTGEPRKVYPYIKRLQTQLLQIPFALASIVVLGGLVVFCNSLEIFINEVYDGPFKQYLAFLPTVFLVVLTPTFSSILMRAATVLTERENYETVDAYHAALVQKQFVLNFFTSYMALLFTTFVYIPFGETLLPLLEFWRRIAQAVVSMGGKTLSTQRFQINPQRIGSQMFYLTVTAQIVNFATEVIVPYVTHKAVVKAHEFQVRGPRMQEQDDEEEAEFLKRVREECLLEEYDVTADYREMVMQYGRFFLVSCFVQNPAASWLDVGATPLTIWHLGYLSLFSVAWPLAACCFLVNNWVELRSDALKIASSCKRPIPWRSDSIGPWLTALGFLSWLGSITSGAIVYLCSHRSQHGTEAAATTTLTAWGGLVSVALAEHLYLLAQLAVRYVMSKMDSPGLQRERRERYQMKRKLLEESVLAEDGDDDDQKKTEKVTRQMLEEEARKASIVGERSAEDMFWQRQRGAEDVIVIGRRLIEKGAASDKVKTKPQPSPRSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LID2</accession>
    <name>A0A367LID2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RAVE complex protein Rav1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_6050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LID2"/>
    <dbReference type="OrthoDB" id="342131at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043291">
        <property type="term" value="C:RAVE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052208">
        <property type="entry name" value="DmX-like/RAVE_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022033">
        <property type="entry name" value="Rav1p_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950:SF9">
        <property type="entry name" value="RABCONNECTIN-3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950">
        <property type="entry name" value="RABCONNECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12234">
        <property type="entry name" value="Rav1p_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RAVE complex protein Rav1 C-terminal" evidence="2">
        <location>
            <begin position="626"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1300"/>
            <end position="1319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI14137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1333" mass="149889" checksum="3471C3471E69822D" modified="2018-11-07" version="1">MITVLPGQPESRLQGLSSGFWNNRHYNAYISGNAFTILEEAHTLVQTIYDDNADNLLVAIALNENSGTIATCSAREIRLYQPLERGHNEVKVVHHPFHVIFMQLIHLQWSLQACFGNPNPSPRTAPSLSWGCTEELLVASTHLSLFSTRKQPVCFWEMKLPSPARLALVSHDSSYIVCVGYFDQLPKVWRRLTYGYDEVRFDVTYLEHPDLVISARWRKLHRTGNTFDNVLYTLCQDNIVRIWIPTDTSDGRHWQVWGSVSLISPGLTKELPGTSRLVCFIDGCSLMSPVKQVEVHPVADHQKSGHDSKNHVVAVVHQTTSDICLSIDRRGRLSAWVFENLGCGDNGSPRALNVAQLSSREFETLGGFLQTNGFPHIQIQCFYTACDETLHFLFHDFDGRIGIFKSKIADLLNPVADGRRLSLQALWTGHSAPIRKIIRNYSGRAVMSRTSNGECILWQHSSRSSNTKDLPLRRRSFTSLGKSVRFICILQQGDLAAFLCDDAIDLWDCRHNTTSRLAGLPMNVSGKPLCLIKLPRSEPGDFKAAHVATITSDRQGVVWEINLSQRPDDTRQSCKAVIRQFCRFNLGIAEDLKHVLPVDPAGSLPILSSFLDIFARDVAISYTHTGRVDFWTARLDPARRGVDWLSTCSTETGISDPALASGSVLKKAALVDSTRSEITIWDIGSSRLEFQQDYNANAIQDLDWTSTPDGQSILAVGFQHRVVLLSQMRFDYLNQGPAWAPIRELSIRHLTPYPIGDSTWLGDGHLIVGAGNQLFVFDRRSGSGESLMADVRLAHRQDGTWDLFEAVRKFNGPLPVFHPQFLSQCVLAGKATLVRQILAALNKILKYLVPGESVDDYLGLDIEKFYTACATQTRTSQRAMGHLREGLSDEDDEEFSAHTASSINEKLLRVGIPQLSGHEQIQLADMVECVTVVERHRRSLDENGARFILFCRQNALRKGRTSEMQLSWREINWAFHSNSQELLVDFVSRQAHGSMLWEHARESGMFMWLSDLNAVKLQFEAIARNIYTEPEVKDPVGCSLFYLALRKKGVLQGLWRTASWNKEQAATRRLLANNFEDSRWRTAALKNAYALLSKRRFEYAAAFFLLADQLEDAVEVCLRQLRDMQLGIAIIRVFEGDGGPVLRKVLGEEVLPMAAQQGNRWLASWAFWMLGRKDMAVRALIMPVHSLLETPCSPNLRSRFFLTDDPALVVLYSQLRQQTLQTLRGASKVTPKLEWEFVLHSAKLYDRMGCDLLGLDLVRNWEFQRQAAAGFGGDVNPLKILRRRSSLIVDDMPAVNWGIAAPTGRDDTRPPPATLSPSFQEPDAASLLDSFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIL5</accession>
    <name>A0A367LIL5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_6130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIL5"/>
    <dbReference type="OrthoDB" id="5312133at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42055">
        <property type="entry name" value="YALI0E03476P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42055:SF1">
        <property type="entry name" value="YALI0E03476P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI14283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="626" mass="69476" checksum="641038D5E0BB3E50" modified="2018-11-07" version="1" fragment="single">PWVPTTLRVPVNCSVDYGRGVLPLAVTRLWAGRGLIHLPRRLSFVRSHSRLSSHLTVVMPPVRFPPRRLSSLLLALVLLALTCVLLLASAVPSSPLTIVAATDGTMSRVMHKSQQIMADNHWLSTPFSGDQAALLPPPLQRRPVYCYHEVTPGSARDDRQAERRLLMTWRRAWWAQGFHPIVLHIAEAKKNPRYASLRRLGLPPAAFKDLSRWLAWETVGAGILTHHTLLPMLPNDATLTYLARGEYSSSLKRWEGLADALLVGTREGVSAALDYAMAHHSSDLLIDSLPEDVIETDTKPPTGLAWYSRAAVESKYRAVAAAFRQSRANGLGALNKLVNTHLHISWQNQFSDGIDALKPYPEHTTTMVSGALKLARQLASCSESPIPSSCPPNLPDCTPCVATAPMRVSTPARYRNSSHVFSIGTVPHPWTLALLHNQRSSLNISWIRRESSRDPWLTTVTRALLGSGVSGNRRVLSLKEAAATAKNSFWLPAEDTMPTDLSWHFGFNVPEHGMDDGRSLSPVPAQRLSHNSESSSDEGDAKETPLLERAKQVVMQTKPTLEAGLRASLEAWNMADTEAWRFVRALHARRLMEMEAARQEAEISSKDEATDEGRLSWSRWRHRLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2024-05-29" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LIV5</accession>
    <name>A0A367LIV5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_6069</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LIV5"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI14349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="70" mass="7939" checksum="84CA882EAE458856" modified="2018-11-07" version="1">MYLCPEKETNFLTVAHGLHIQEYYTIHIFLPRISSNGQIHRLDAMPVRVTTYYCSSSSSSLPVLVVLLPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJ83</accession>
    <name>A0A367LJ83_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Charged multivesicular body protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_6084</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000004">
        <property type="protein sequence ID" value="RCI14437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJ83"/>
    <dbReference type="STRING" id="1330021.A0A367LJ83"/>
    <dbReference type="OrthoDB" id="441172at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF5">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0967">Endosome</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="170"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI14437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="208" mass="23188" checksum="1A583C2BFCFDD9DD" modified="2018-11-07" version="1">MGGKPSKVTAQDKYLLYSAILDLKSQRDKLHQYQRRITLLTDKETDVARKLLARGDKKGALLALRRKKYQESLLSKTDAQLEQLEKLTANVEFARIQKDVVFGLQQGTKVLKEIHAEMGGIEHVEKLMGETADAIAYQQEVSDMLGGRISNQDEQEVEDELAALQADVEGEHKELPSVPIARLPGRQTDAAQESVQPTEPERPAMLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJD1</accession>
    <name>A0A367LJD1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7111</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJD1"/>
    <dbReference type="STRING" id="1330021.A0A367LJD1"/>
    <dbReference type="OrthoDB" id="10261522at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044715">
        <property type="term" value="F:8-oxo-dGDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03676">
        <property type="entry name" value="NUDIX_Tnr3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000019">
        <property type="entry name" value="Thiamin pyrophosphokinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031804">
        <property type="entry name" value="DUF4743"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF8">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15916">
        <property type="entry name" value="DUF4743"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="141"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI14510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="485" mass="54777" checksum="28620EFB675F66B9" modified="2018-11-07" version="1">MLLNIDVVNAVDKSVSLLISIVELPYGQDQAIISTISELAYNNLHMLLWEDDEGRYPIGYILDRVVRELLRVPVVVRGHMDFDENKRTVLLFQLNTEPERTRAVAGLVHYWRDHDTFKLLQRWRGEVCPIYGRKGEILFSVERAAVGLFGTVQFGAHLTAYVTDASAPYRIKLWVAKRAANKTTFPGMLDNTVAGGLATGENPFDCILREADEEASLSVDLVSRFIRSVGTVTYIYITDEAQVGEDGFIYPECQWVYDLNLPANIIPQPKDGEAEQFFLCDVDQIGADMADGRYKPNSAIVLLDFFIRHGIIKDADNSRLDVIKQRIHRNLPFPGPHEKDWYQVKNRKTNKTCNVTTYISCEISSFDQEIYVINSQWSSYKASSRMIIMQLTLSAMVAGRSPPLPVSRQPFSSSFVPSGDSVVVRTTCRESDTAHGKSSILISRVMIVCVSLEVHEIRATRSYFDWSYRVATASTCHYERAGFNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJK9</accession>
    <name>A0A367LJK9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_6377</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the sal C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJK9"/>
    <dbReference type="STRING" id="1330021.A0A367LJK9"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000793">
        <property type="entry name" value="C2H2 finger domain protein FlbC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001102">
        <property type="entry name" value="Transcription factor IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051565">
        <property type="entry name" value="Sal_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23233:SF84">
        <property type="entry name" value="FI23031P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23233">
        <property type="entry name" value="SAL-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="311"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="185"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="60"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="185"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="336"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI14616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="351" mass="37890" checksum="F326DFABC80722F1" modified="2018-11-07" version="1">MTMTLPTSQQQRFGPPLNFDYAQQPPPAFSNPWSTTTASSTQHSAPYVQQEPHNLMAAKPQQPASRTSSASAPSMAPFASLPVAPAAPADLLSLQNRLHSTPAAYTDATYPATASPVTGPFTATSTAPYDALAYTSAQSRPSSTFAINAEAERRYSQQQAMQSQADERRSFADALDASHGMLAMSQETPRNIYGTRSNRSSVDSYGFPSTHSTSSSISSSGNFSSYYGDSVSDYSTAGSDIESVNSRTLPRPQGLITSQIPPAPQSMMGQFSSKVSSSSQKKHKCKVCDKRFTRPSSLQTHMYSHTGEKPFACEVEGCGRHFSVVSNLRRHRKVHRGDARSEAGSEDHHSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJT9</accession>
    <name>A0A367LJT9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cwf19-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_6939</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJT9"/>
    <dbReference type="STRING" id="1330021.A0A367LJT9"/>
    <dbReference type="OrthoDB" id="444325at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061632">
        <property type="term" value="F:RNA lariat debranching enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07380">
        <property type="entry name" value="MPP_CWF19_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040194">
        <property type="entry name" value="Cwf19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006768">
        <property type="entry name" value="Cwf19-like_C_dom-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006767">
        <property type="entry name" value="Cwf19-like_C_dom-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072">
        <property type="entry name" value="CWF19, CELL CYCLE CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072:SF4">
        <property type="entry name" value="CWF19-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04677">
        <property type="entry name" value="CwfJ_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04676">
        <property type="entry name" value="CwfJ_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cwf19-like C-terminal" evidence="3">
        <location>
            <begin position="292"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="Cwf19-like protein C-terminal" evidence="2">
        <location>
            <begin position="485"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI14705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="537" mass="59311" checksum="2AA5ACE192492C87" modified="2018-11-07" version="1">MANPKIIVLGSLDGELESAAQKLATLQAKNGFSMAILTGNAFAPTLEANVYEALANGKLTFPLPTYFTVGTHPLPEQIAAKVEADEEIGQNLYFLAKRSITTTADGVRIAVLGGFPGSAQADADAKNFFHTDDDAKALRGGTSRIDILLTSIWPADIWRGTSIVLEPAHQAVVKSTQTIANVCAGLKPRYHLAPSAGAFFFEREPFEHPSTTDSEADTKVFTRFISLAPYGNSAKAKSMYAFSLNKSDAVPAGATTSPFLVHSKKRTRDEEAYGRFGRYHDDDGRRGRGRRPRERPGPNRCYFCLSNPDVSTHMCCSIGDESYISTAKGPLPTPTTFSEHELTFPGHFIIIPLPHAATSTAMGTAEEAKRTYDEMSRFRNALQAMLSTVSSHKLGAVTWEISRERNVHLIWQLIALPAEMIQSGVAEAAFRVEAENHGYPTLIADDLTLEKQATCGDFFRIWLWADNGEDKITGKSLVMPLFQGLPFDLQFGRRVVAKLLGLDARFIWQQCQQTVEEEKRDVEAFRRTFKDWDFTLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LJW2</accession>
    <name>A0A367LJW2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 7 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_6897</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LJW2"/>
    <dbReference type="STRING" id="1330021.A0A367LJW2"/>
    <dbReference type="OrthoDB" id="1937997at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000005">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000037">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000027">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048723">
        <property type="entry name" value="OB_PRS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21236">
        <property type="entry name" value="OB_PRS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="215"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI14689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="440" mass="49175" checksum="340354284731A574" modified="2018-11-07" version="1">MPSATGQNWEKYQKTFADDEIEEKKITPLTDEDIQVLKTYGAAPYGASIKKLEKQIKEKQQSVDEKIGVKESDTGLAPPHLWDVAADRQRMAEEQPFQVARCTKIIEDEKGDESKKKYVINVKQIAKFVVQLGDRVSPTDIEEGMRVGVDRNKYQIMLPLPPKIDASVTMMTVEEKPDVTYGDVGGCKEQVEKLREVVEMPLLSPERFVNLGIDPPKGALLYGPPGTGKTLCARAVANRTDATFIRVIGSELVQKYVGEGARMVRELFEMARTKKACIIFFDEIDAVGGARFDDGAGGDNEVQRTMLELITQLDGFDARGNIKVMFATNRPSTLDPALMRPGRIDRKIEFSLPDLEGRANILRIHAKSMSVERDIRWELISRLCPNATGAELRSVCTEAGMFAIRARRKVASEKDFLSAVDKVIKGNLKFNSTATYMQYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LKN4</accession>
    <name>A0A367LKN4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Golgi apparatus membrane protein TVP23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_6769</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Golgi membrane protein involved in vesicular trafficking.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Golgi apparatus membrane</location>
            <topology evidence="2 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TVP23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI14960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LKN4"/>
    <dbReference type="STRING" id="1330021.A0A367LKN4"/>
    <dbReference type="OrthoDB" id="2151161at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008564">
        <property type="entry name" value="TVP23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13019">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13019:SF7">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05832">
        <property type="entry name" value="DUF846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI14960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="198" mass="22276" checksum="0DA5FDABC79B11C7" modified="2018-11-07" version="1">MDSSTATTAHHPASGSLSWRLSSHPITLLTFLIFRTSSVVIYFLGLWIIKSMIMIFIITILLLAADFYYLKNIAGRRLVGLRWWNEVDAQTGDSKWVFESSDPSSRVINATDSRFFWLALYVQPLLWFVMAILALVRLQFLWLPLVVIALILTIMNSLAFSRCDKFSQASNMAGSALGTTNLAGSIASNMVGRWFSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LL77</accession>
    <name>A0A367LL77_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LL77"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="248" mass="27891" checksum="E384861002AF4A62" modified="2018-11-07" version="1">MLMRAAATRRRSEESSVVYILERQASTLDNVYSRRQQPRPREMLDIVSRKPPNETGSYKQNDQDSSLSISGVKHSLDLMPSVCVVLGGGGEKCAMPNGEPDEQKGHLAILELLATRISRPNIGCNGQNSDTSRLSSVHIIPRRDGMVNIPIDLDFIPSLYIGKHVFLSLLRAQSSHGVYVFFFSPSPVDLPTDVWALLTCPWAAPQLNKFGYDEDGCVVFVKAHLINLKWENHVFEYYLMHIMADYQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLB0</accession>
    <name>A0A367LLB0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Steroid 5-alpha reductase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6443</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLB0"/>
    <dbReference type="OrthoDB" id="201504at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251:SF23">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE (DUF1295)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="148"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="353" mass="40290" checksum="D5AB1E9F397337D0" modified="2018-11-07" version="1">MFLPVLKSVRDCADFTLTVKPFIGQLYALPQRLADVRSLDGLSQVYVETNPLMTAFAASILLGGIFLVASEVNRNYSQVDRFWSLLPNLYVIHLAVWARLAGVPHGRVDLIAIFTTAWSCRLTFNYWRRGGYEIGSEDYRWEIVKSRMHPIAFFVLNLTFISFFQSVLLFSISCLPAYVILLSSRVEPHVSAIDIAYLTVETLLVFSEWISDGQQWTYQTAKRQYQKDAKLPKGWDQADLDRGFITSGLWAYSRHPNFLAEQAIWFVLYNWACQATETLYNWSFVGSASLVLLFQGSTMLTESITSGKYPEYADYKKQIGMFMPTSLRGYQPPASNYTVIKSTGPARESRKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLG7</accession>
    <name>A0A367LLG7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FMN hydroxy acid dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_6825</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLG7"/>
    <dbReference type="STRING" id="1330021.A0A367LLG7"/>
    <dbReference type="OrthoDB" id="25826at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000029">
        <property type="entry name" value="L-lactate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF86">
        <property type="entry name" value="DEPENDENT DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G02720)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 7" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="8">
        <location>
            <begin position="32"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="111"/>
            <end position="113"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="294"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="325"/>
            <end position="329"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="348"/>
            <end position="349"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI15102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="407" mass="43827" checksum="6A516AA0745E63DE" modified="2018-11-07" version="1">MAADHQDDDEPVPISYAAHLDHVMRKAAADGQLSVVPKNPVLLEDQAQRLMSQRGFDYVNGGAGELVTLNANRLAFRRWSIIPRVLRPTSPRDLSVTLFGHKYDTPVLMAPVGIQSVYHPDREIGSARACAALRVPFTLSTAASTGIEELVEESPEGAKWYQLYWPADDDITASLLSRARAAGYSVLVVTLDIWTLKGWRPRGIDTANVGFEDPVFRAKFAKQTADGRPPEADKEAAVAFWLGQCFPGISRSWDQLAILRKHWDGPIVLKGILSVEDAKLAVQHGIDGIIVSNHGGRQVDGAVATLDVLPHIVDAVGSDTTVMLDSGIRTGADMVKALALGAKAVFVGRPILYGLGIDGTAGAQAVLAGLLTDLDLTMGYAGVENVPELDRTVLREAELPGHGRPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLL9</accession>
    <name>A0A367LLL9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_6796</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLL9"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI15152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="97" mass="10653" checksum="7D08EF6259D29138" modified="2018-11-07" version="1">MGREDRRRYLYGVSVLFKVLAGGWGGGIRWCGGSKTKHVPPLEAGANLRLRIKRAGINSDTRKSQYVSGCFASLPSHPPSPFVWKAPRASGRAKKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLT0</accession>
    <name>A0A367LLT0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_6616</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLT0"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI15395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="267" mass="29124" checksum="FFE215B1A2BC5129" modified="2018-11-07" version="1">MRPSASRAVFSPARAKQGPPLDNLINGLRSVEAGKMSIYQLQSWNNSLERGQRHRPCQQLPHARAVEASRLQLGAHANAQKFAVVQEADMESWPEFSSHGEASSVRGRQVTPTHTSRWRGRIGLSIGLIECPTADERLRAMLTSSRWANVEDGPAGFILVAAVSGFSNVKLPAKVSAMRHRGLEGIFPRQTAGATRLLLMAVGCLKSVSPGECVEQSGMLRVTSVTRLRTENPDGTVRSKARRFTGFPCPPPSLLNDDWIDVATTCM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LLX0</accession>
    <name>A0A367LLX0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3461</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LLX0"/>
    <dbReference type="STRING" id="1330021.A0A367LLX0"/>
    <dbReference type="OrthoDB" id="10039566at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022185">
        <property type="entry name" value="DUF3712"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046368">
        <property type="entry name" value="Tag1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895:SF1">
        <property type="entry name" value="LIPID-BINDING SERUM GLYCOPROTEIN C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12505">
        <property type="entry name" value="DUF3712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="352" mass="38715" checksum="1ED0EC8C835787D4" modified="2018-11-07" version="1">MSSDAKNMTSETQHDAQVGRNRKRGCVNHCKRFWWAYLLFLCAIVVLVVCLISQVFSGHSIFVAVPKIAQHKMDDSKLEIQGVHVLETRPNSYLMEINSTITTDGSIHADIDGFQGNLYIDSDENSVPFATLDFPPTVSDKLVLVNISQTVQIRDRAAFTRFNTLFYQNKAVRVRLSGKTKVKPSGLSRKYDVDFSKILEFDGLDAFGGTKVDGSVDIGAPAGSPNFRGTADIPNRSHFTLDVGNASFTNFADGQNIGSMTINNLVIRPGINKVNVEAELDQLKVLQIIGKKPYCDNGIVPFELLATDVVRNGEKLDYFATALASRNQTVDIDIGSILRKTIPGFSLSCSRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LM19</accession>
    <name>A0A367LM19_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_6602</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WHI5/NRM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000003">
        <property type="protein sequence ID" value="RCI15302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LM19"/>
    <dbReference type="OrthoDB" id="5345625at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013734">
        <property type="entry name" value="TF_Nrm1/Whi5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08528">
        <property type="entry name" value="Whi5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="85"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RCI15302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="201" mass="22468" checksum="3C07A816252F8C1F" modified="2018-11-07" version="1">MMESRLRRTLEGGDRDREQATPSPTRQRQGAMTSSPTSRKKNRQRQTKTTSSPTTKTDDALTRLDVNVRASTSTTAEEKKKELMVNDDDEEEEEEEEEEERLDGRDEGSSSPEASSVFDTSVADASWATAATHEVEAATEPLLLPHQLPTRLTREQMREVEVLRLRLGLASYKVRTGQTGIALRDLQARPLRRGGGSAWVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LM97</accession>
    <name>A0A367LM97_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fibroin-3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_3613</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LM97"/>
    <dbReference type="STRING" id="1330021.A0A367LM97"/>
    <dbReference type="OrthoDB" id="5401332at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005935">
        <property type="term" value="C:cellular bud neck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037504">
        <property type="entry name" value="PSI_induc_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40018">
        <property type="entry name" value="[PSI+] INDUCTION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40018:SF1">
        <property type="entry name" value="[PSI+] INDUCTION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI15548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="354" mass="38706" checksum="11993A4DA1E1B533" modified="2018-11-07" version="1">MSPVDVAVVGRDLGMSAKRDLLIDAADRVGDVKTAFSSWDNCMKVGYCKWPVIAVIAVGSLILLSVVWCICFRCCGNCCGCCDAPNRRQQNYLEEPYIPPGHGYQTQPPMLASGAFPPQYAQFDVPRKGGADALPEMPSWESGNSKKVMVEDDEVEMNQLNNNNNKRVSSPLAQAPMAPSTISSTLVYTPGYSHQSPDVSYERGYFDHEPNNNAYGLAQPTPRSPSRPYNLMHQDTGDSFTRMGRQGPSPYPAARADYQYPPNSTPAPREPQDYASPGYGYDYPRAHSTSPPAEAWPASHQSPITNNAGFDFTSGYARPTNADADVNPRYPSPPTSSTPVYPGYKPYQPPSQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMD7</accession>
    <name>A0A367LMD7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">L249_3429</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMD7"/>
    <dbReference type="STRING" id="1330021.A0A367LMD7"/>
    <dbReference type="OrthoDB" id="3638488at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF400">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CBK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="296"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="12">
        <location>
            <begin position="644"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="125"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="129"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="332"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RCI15578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="796" mass="90700" checksum="8EE375AA7AF1E0E0" modified="2018-11-07" version="1">MGPGLLQKRNCPAVDASSLDLRLGSVDSNTSRAGSKVWSEIRGAIRALGKSGRNDSESSTVLTWRPDGTQTTRDKGKAVVLGQGREPVRRTKGLMPKDLVRKLGLHEASTVVQRDSPLKARVSLQLHASSGSSSTVSSDSSSKMSTPGNESTRKTSVDSRFSDLTQMKDTPKRRRSRRRPWSRSSPDGGTLQTIEESSQSVQPTILTVERAAAAKIYLELYFNELLNKPSARCLRRQLLESQLYCAHHLTGDQKEAIRRSFQLQETCHVRETRVLGSRSVSSLTAPDRPVSHIERYQPVKVLGRGSFGVVKLVRDTSESSGNQVLAMKVIRKSDMLRSNQEGHLRAERDFLVASEGSDWIVPLVASFQDPKNLYLVMEYMPGGDFLGLLIRENVLHESVARFYIAEMILAVEEAHRHRMIHRDIKPDNFLISASGHLKIADFGLAFDGHWSHDASYYSCQRYSLLQRFGIKVDGDSEDQKKCEGIATQLPWLQSMREVLQRHEKPSETRDLPRLLGWRNRCGNRATAHSVVGTSQYMAPESIGIILYECIYGCTPFFDEDGRKQIKSNILDHRNLFSFPHRPMVSDRCKDLMYHLIQDKEFRLCSKRYKMKDRTELDQGRKTDCFGRFVFPDDADEIKAHRWFRNLPWDRISTMRPPFVPHIANDEDTRYFEGSDPMDTSTGSSRRDMELTPDQVRATLHEFRPYVQNLAVDLMAAPFDSARLRSADDGIDSTARLTASERMMLKQFIRIYGRKEQKRPRDILLRDESIKDVVMDVRKKTAFIGYTWARRRPCGYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMH7</accession>
    <name>A0A367LMH7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_3471</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrion-specific ribosomal protein mL54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMH7"/>
    <dbReference type="STRING" id="1330021.A0A367LMH7"/>
    <dbReference type="OrthoDB" id="10252718at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013870">
        <property type="entry name" value="Ribosomal_mL54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28595">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L54, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28595:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08561">
        <property type="entry name" value="Ribosomal_L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="68"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI15587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="213" mass="23784" checksum="AA9108107BD23CF2" modified="2018-11-07" version="1">MRRKELRPCMLRQLTIDGYPRLASSKTMTMLCTRCLRAVRQQLRRFSTYPPLLSSAPVLSTPITKPGEAPPPTEPPPARSICVAGTVLTGLNFTKGGKDPVAMKDEDYPEWLWSCLDVIKTKSDKGNHDAGDEFSKSKKTRREAAKRARALEAAGGLTAPKIPVQRQSINLPGEEGGSVEDNIDAIYKREELRKAMRKERKAKIKETNFLKSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMS0</accession>
    <name>A0A367LMS0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_3324</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LMS0"/>
    <dbReference type="OrthoDB" id="1893551at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051625">
        <property type="entry name" value="Signaling_Regulatory_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872">
        <property type="entry name" value="BTK-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872:SF2">
        <property type="entry name" value="INHIBITOR OF BRUTON TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="436"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="489"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="1005"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="148"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1248"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1328"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1393"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1495"/>
            <end position="1570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1602"/>
            <end position="1668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1273"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1506"/>
            <end position="1517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1520"/>
            <end position="1532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1645"/>
            <end position="1657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1658"/>
            <end position="1668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI15745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1668" mass="183319" checksum="9489F99D55FCF890" modified="2018-11-07" version="1">MTFETFVNYLDESRTKALGNQMMPSVRRQCTLRIVLVVMGSSTVEPRNQRVTLLPATSLQTVFTNFIHEVLRQKMESRVVRLLSSHISFVKVSSSQSLQPHQQPVNNGLRYRPMSHLLWKYYWENDVDRFRRLLAPGGFTSHASAAKSTAIGSGGSSPGGLGTSPRNAYKNRRPQAFSSASTRSRDGGSSLGRSDVNSRDHAGLTLLLRAASSTDTRAIEFVQALAEHPSIDLYVQDPESGWNALHRALYSGNASIARLLLASERGALVNCAPQSLVKVGQLFKMKDHEGNSPFDLYNLTVSKTVCETVLESLRLCPRPEDSDSNDEVMQIGIKPSGSMKPSAEGGELYVFGSNKNVSLGLLDDDYKVPKRIPLQRPNGLLHHLHKLSIDGQVTDCSSSSPDIDSIPNLVRDKPIVIQEVAMSKLHSAVLTTDPVSNLYMCGVGRGGRLGLGHENTQFKFLPVQGPFADRKILKVALGQNHTLFLTDNGELWTCGLNSDAQLGYALPPPARTDEEPVSLTPRQVFGALKKEVVIGVAASAIHSVAHTGSSLYCWGRNAGQLAVVDSDSRSLDLQQTPRRVAASLLSAPIEMVSAIDKATTCLLSNYTVWVFTNYGYNLVKFPIPVILRNHDLVARSFSSRLNPGWKKIRYITSGGETIAAVTSRGDLFTMQINHQKDDSQPAGSTTNPVKMRSAVTQPKCIWNSRKDGVSSVSVGENGSVILCTKSGAVWKRVKRQSVQVAGFSSSGIEKNDFKFERVPYLTDCVNVRSSVFGAFAAVRRDKSNMSDSIGIENPSLWADMACLCCLHDFKPSEPFSDMDQPDMWNASDMRGRIGCLSFEILRSLDVERDISPYCFQRGDLDVGIRTTAAPNIMIPVHGFVLASRSRVLREAFCAFRRGTISTSHSDTFQLESDNDKLVVTFSGVDIYTILNVVVFAYQDDILAGWLYARSARNRFRQVRSEVMKLATKLQMPQLEAVARLQTGRKRSLGADMLEAISDPAFFDDGDVSVQLRDGDVIVHSQLMCQRCPFFKGMFQGRSQGQWLSQRRSESPASEPVRINLEHIDLDTFHYVLRYLYADVGEEMFDEVTMPTIDDFSEIVLNVMSAANELMLDRLSQICQSVIGRFVNTRNICNLLNEISPCSVTEFKDAGLKFITFQLECMLENQLLDCLDEELLRDLDQVVRHAQLERCPVPRSGRAELLLHKNYPDLVMDIDEERRRRVREMAFKLTHKDEEKRLSSLHKARVGSLDDVLSAPPPAERICTTPKASRSEQDSPTLRSKQSQGDMIFSMDEEVTFGATSPLSSMPSVSGSRQHIDLENMQQLPEAWRSGTGKEPAEKGKTSSLSPCWTHGTERVSGEVALETNVPSRKPSGPWASPALSGSRVDLRDIMSEASSKPGLRSGLATRISKSPSFSRPPVKMSQKERKKHLQMQAEAATQVGAPLQASGDPELAAGSRSQPWKVVGVASKASLSETTLSAEPVAAVVKKPTAVAAEARPYLNPRRTGSPDTRFSGQGRMSCSAASAAVPGPVGPSKKETLVPHSRSYMTAAPKASPSFGASMADIIGQQKREQELAKEAVAKRSLQEIQQEQAFQEWWDLESRRAQEDEAKRQAKLQDPGSETTHRSGRRDKARATEATGTGGGGESSRHGGKGQERGKGKGKGAKGGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LMT9</accession>
    <name>A0A367LMT9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="14">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">L249_2220</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 14">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="14"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LMT9"/>
    <dbReference type="STRING" id="1330021.A0A367LMT9"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000020">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 14" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="18">
        <location>
            <begin position="61"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="17">
        <location>
            <begin position="207"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="19">
        <location>
            <begin position="469"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="20">
        <location>
            <begin position="571"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="21">
        <location>
            <begin position="653"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="15">
        <location>
            <begin position="700"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="16">
        <location>
            <begin position="1078"/>
            <end position="1163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00053978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="RCI15728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1171" mass="132297" checksum="5055E3910BF6343F" modified="2018-11-07" version="1">MADDAFEALLEPFYNGKKLTDPISTKEDKFQLLPAFLKVKVRTTSLVLELLAAFTDPGICRHIDSYNFFAEEEIKNIVRANRTIRSDVDSNFWLEFTDIRVDRPRRQNYNDAKSRTEVTPMECRLRDMTYAAPILVDIAYIRDRQRIVRKDVPLGRMPVMLKSSKCRLSGANNSQMEAMNECPLDPGGYFIINGTEKVILIQEQLSKNRVIVEADDKNNVISASVTSSTHERKSKTYVTLKKDRILLTHNVLVEGIPIVIVLKALGGLSDYEIIQLVAGSDGRYQDEFLLNFHEATKVGVFTQHQALEYIGARVKMGSRKAQFGPQVRRNSIEEGLDALANLVIAHVPIEGLDFYPKAIYVAMMTRRVLMASQDRKLVDDRDFVGNKRLELAGQLLSLLFEDLFKRFMVEVKMNIDKFLKKNNRAVPLDAVHMISNYANNIGLGINRAIQTGNWSVKRFNMNRAGVTHVLSRLSYISALGMMTRINSQFEKTRKVSGPRALHLSQWGMLCPSDTPEGEACGLIKNLAMMTHITTNIEEGPIKKWILTLDIGVEPIRNFSGAEIHRAGTYTIHVNGTPFALTRYPKRFASRLRTMRRRGWISPFVSININSYFNAVYIATDEGRICRPCIIVKNGKQKLKPEYLRLLQQGKASFDDFLRHGIVEYLDVNEENDALICIYEDEITHSTTHLEIEPFTILGAVAGLIPFPHHNQSPRNTYQCAMGKQAIGAIAYNQFNRIDTLLYTLVYPQRPMVTTKTIELIHYDKLPAGQNATVAVMSFSGYDIEDALVLNKASIDRGFGRCQVFRKYTTELQKYPNGRRERIGDPANEMAGGSWQRIEKHRALDDDGLATVGYRVKAGDVMVKKETPLDQATTGIGMDRGPSEYIDSVVSYRVPDPAYIDKVMISQTEKDTTLIKVQTRQTRRPELGDKFSSRHGQKGVVGIIVDQEDLPFADNGLTPDIIMNPHGFPSRMTVGKLLECLTGKASVVAGRKDYGYGDAFRSHPVDEMSKVLLDHGFSWEGKDYFTSGMTGEPLEAYIFNGPIYYQRLKHMVQDKMHSRSRGPMAILTRQPTEGRSRDGGLRLGEMERDCLIAYGSSQLLLERLMHSSDGVEIDICQQCGLFGYGGYCHTCKSTRQVTTMRMPYAAKLLVQELISMNVGVRLQLEDEFPHPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LN05</accession>
    <name>A0A367LN05_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2485</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LN05"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="152" mass="17328" checksum="110D3ED04211C074" modified="2018-11-07" version="1">MGDGRGGVAINLSLSLSRYRVRRWARRRTRDGDGSTGHVRVENKRRHSRMSSGRRSLVWEKRANRQRELQAEVMSGWVVWEVRVSPATTKLRYRQGPARFPPALEPSGVGGRGGPARAAWFPKQRGQRVQCWSASLRTELCLGLRTVDWGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LN59</accession>
    <name>A0A367LN59_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar protein sorting/targeting protein 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Carboxypeptidase Y receptor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15 17">Sortilin VPS10</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18 19">Vacuolar carboxypeptidase Sorting receptor VPS10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">L249_3509</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes multiple rounds of sorting by cycling between the late Golgi and a prevacuolar endosome-like compartment.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Prevacuolar compartment membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000002">
        <property type="protein sequence ID" value="RCI15682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LN59"/>
    <dbReference type="OrthoDB" id="443634at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.270:FF:000005">
        <property type="entry name" value="Sortilin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.70.80:FF:000001">
        <property type="entry name" value="Sortilin-related VPS10 domain-containing receptor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.80">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031777">
        <property type="entry name" value="Sortilin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031778">
        <property type="entry name" value="Sortilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006581">
        <property type="entry name" value="VPS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050310">
        <property type="entry name" value="VPS10-sortilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106">
        <property type="entry name" value="SORTILIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106:SF27">
        <property type="entry name" value="SORTILIN-RELATED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15902">
        <property type="entry name" value="Sortilin-Vps10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15901">
        <property type="entry name" value="Sortilin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00602">
        <property type="entry name" value="VPS10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110296">
        <property type="entry name" value="Oligoxyloglucan reducing end-specific cellobiohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-0675">Receptor</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 22" id="KW-0732">Signal</keyword>
    <keyword evidence="5 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="22">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016794916" description="Vacuolar protein sorting/targeting protein 10" evidence="22">
        <location>
            <begin position="23"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1378"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1429"/>
            <end position="1450"/>
        </location>
    </feature>
    <feature type="domain" description="VPS10" evidence="23">
        <location>
            <begin position="48"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="domain" description="VPS10" evidence="23">
        <location>
            <begin position="731"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="657"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="667"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00031902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00032705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00032910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="SMART" id="SM00602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="RCI15682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1512" mass="168410" checksum="2BBA5E9FF3A477DA" modified="2018-11-07" version="1">MKLGGSAWRILLASLLWTLALAKDAPDMAVNKFNHPPLSLHYFEDSDVVVFHDVHERNVYRSKDAGASWSRVDAVPEGKTIALVMHANDHKSAFVLTASGDHYKTDNRGEAWTKFRTKSIPSKFQPEILIFHADDPNRIIFNGMDCEGIFCDEQALYTTDGFKSVKLLRSFTVGCWWARSTKAFTTGDADLDKSRVLCVVKDPFSFFRQDQRLLVSDSYFAVAGSTIQEFEPNIDGNKGASGVMNFAPINKFILVATSSARSDEMALFVTQDTIKWHRAMFPTDSNHGHSHRVHQEAYTVLEGTNYSIQIDVMTARPSNPMGVLFTSNSNGTHFTENIPYTNRNTKGHVDFEKISGIQGIFLVNVVDNGAEVNNKGAKKTIVTKITFDDGRTFHDVKVGRDRLHLHSVTELDNVGRVFSSPAPGLVMGNGNVGKSLTKLTEANLHVSDDAGLTWSKALDGPHKFEFGDSGSVLVAIKDSAKEDVKDYSYSLDHGQSWKSVPLPDDISIKPEMLTTTQDSTSLKFLLVGQNKKIYHMIAINFEGLHERTCGDGDMEDWHARVDEDGKPTCIMGHKQTYRRRKKSADCFVKHEFKDPEPKTEDCECADIDFECDYNFQRDADDSSKCVKAGPIPVPDGECAGNADGSFKGSSGWRLIPGNTCKRTGGSQKDDKVDRKCSDSVPAPAPPASDKVTSKKVEFESKLKDFDKIYLERSDASSSTDETIIFRPAEYDGDGRMKVENKLWISHDHGKGWERILKGEDVEGVYPHQYFKDVVFFTTTSKTVLYTMDRGQSFHKIEAPTKSLAKEINLSFHADKKDWLIWLGQKCEKVGDSESCYKEASLSTDRGDNWRTIQRYVERCEFTGNSAYNFRQSKQIVCLVRKGEKKAGPMTVVSSDDFFFEDKTTLEGDVINFATMSEFIVLAAKDEKTKDMLALASLDGKHYDKAHYPHNFREGHENQYTLLDSSTHAINLFVRTEAGVDRQYGSIIKSNSNGTSYVLSASNVNCDESSYVDFEKVAGLEGVVLINVVTNTDKKERNKVLQTKISHNDGSEWGYLAPPAKDADGKAYRCSSSKGDASCALHLHHFTERDDRRRTFAADTAVGLLFGIGNVGSSLGDVKDADTFLSTDGGMRWKCVKKGEWTWQYGDQGSIIVLVQRATRAKPVKTKMVTYSLDEGQTWTDHQFSDSDVSVLDITTLKSGTSRNFLLWCRAGGKAFTVNLDFSGLTSRACKFDKDAVSDSSDYYLWSPKHPLQDDDCLFGHVARYLRKKTDRKCYNDQSLHRLFDHKDCPCSRRDYECAYNYELDKHGQCTLVAGLKPLTGEEWCAKNANASSWFEPTGYRKVPLSTCQGGNELDKTSTEHACSGHEEEFEKKHRTSGAVILLALTVPFALAGAVGWYVYRNWDGKLGQIRLGEQTSTFDSDRVWIKYPVMAVSAAAALVAALPLIASGLWRSATGTYGRVRGESHGAWFSGGGGGGGTRRFTTRDSFARGRGDYAMVDDEGELLGQESDEDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LN71</accession>
    <name>A0A367LN71_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">dihydroxy-acid dehydratase</fullName>
            <ecNumber evidence="14">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">L249_2489</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:27695"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="14"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LN71"/>
    <dbReference type="STRING" id="1330021.A0A367LN71"/>
    <dbReference type="OrthoDB" id="3851628at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00057"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.80:FF:000001">
        <property type="entry name" value="Dihydroxy-acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="entry name" value="IlvD/EDD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050165">
        <property type="entry name" value="DHAD_IlvD/Edd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004404">
        <property type="entry name" value="DihydroxyA_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056740">
        <property type="entry name" value="ILV_EDD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="ILV_EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00110">
        <property type="entry name" value="ilvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002068">
        <property type="entry name" value="PRK00911.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000:SF13">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24877">
        <property type="entry name" value="ILV_EDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="IlvD/EDD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00887">
        <property type="entry name" value="ILVD_EDD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase N-terminal" evidence="17">
        <location>
            <begin position="87"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase C-terminal" evidence="18">
        <location>
            <begin position="410"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF24877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RCI15831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="606" mass="64396" checksum="574F3A1CA27C74EA" modified="2018-11-07" version="1">MATQPSPLPDPKAPPDYLQFKCLPSENPTRLNRWSTNLTREHDLPGAQAMLYGAGVPDEKTMRTAPHVALSLRSDPVNSSLLRLVLDLGNIVKAAVEKNGMLGWQFNTVGVSDAITMGGDGMRYSLQTRELIADSIETLTAAQHHDANISIPGCDKNMPGVVMAAARHNRPFLMIYGGSTRKGYSALLGREVNVTSCFEASGAFAYGNLRAETDADLPGREPVDVLDDIVRHACPGPGACGGMYTANTMATAIEAMGLTLPGSSSFPAQSPEKARECQRAAAVIRVAMERDIRPRDIMTRAAFENALVLLMILGGSTNGVLHLLAMAHTADVPLSLDDVARASDRTPLLADLAPSGRHLMEDLHRVGGTPSVLKLLIARRLVDGSIMTVSGLTLAESVADWPSLEPGQTIIRPLDAPIKPSGHIRILRGSLAPDGAVAKITGKEGLQFKGEAAVFDCERDLNEALTAGSVRPSAARPLVLVVRYEGPRGGPGMPEQLRASAAIKGANLTHIALVTDGRYSGASHGFIIGHVVPEAAVGGPIALVRDGDTITIDAVANEIHLEVEDDELQRRRAEWVAPPPRVKRGVLAKYARLVGDASHGAVTDAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LN97</accession>
    <name>A0A367LN97_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI15888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LN97"/>
    <dbReference type="STRING" id="1330021.A0A367LN97"/>
    <dbReference type="OrthoDB" id="4174112at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022190">
        <property type="entry name" value="DUF3716"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12511">
        <property type="entry name" value="DUF3716"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI15888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="462" mass="48058" checksum="911B81713C5A1C3F" modified="2018-11-07" version="1">MAGQGGEIVESSGSAGRRSSSLSPSMESQMLQLYNAVHNPQVPAVQDAAFASQQQLGFQMSGGSPRAGPVGDDIVDSSAGSAGYADNSGFVHEQGQFSPDTSGGLMPSPAGNYGVDPTLFGNIDPQLLAYQAQEIERQNLAAANAQAAGGPPHGVESRHELSVKLANLPVVRLPVQRRATQGLNMNRRCNVEAALAYISGQQPTKSCSCCAKTFGPWNDCVVYEGQMLGACSNCWFNASGSRCTFQGDKHPKPEPDQEGQESQQGSPSPSAAAQSSSPQPPVAQAAAAPGTQPTSGSRRNSPSGAAASPSRSARNRTSTPASRRGSPGRAAATASSRSPSASVGGIDPPANVTDHDMAHWRLADSTRRALERGLNDPARMSDPAAGASIRRRLVARIESAAEELGVRMAEFDEFSRSPAGMAAERVHREARREAAATRRDAREGGNNGGGGGDENNNNNNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNT5</accession>
    <name>A0A367LNT5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_3172</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNT5"/>
    <dbReference type="STRING" id="1330021.A0A367LNT5"/>
    <dbReference type="OrthoDB" id="9972683at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004414">
        <property type="term" value="F:homoserine O-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009092">
        <property type="term" value="P:homoserine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005071">
        <property type="entry name" value="PRK06489.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF11">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016942513" description="AB hydrolase-1 domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="169"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI16047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="456" mass="51207" checksum="E57CE07434476FC7" modified="2018-11-07" version="1">MRTLFGLVFSTLVGSVSLAQEEAGRHHACPTVTSTLSICSTCIRPMCIVAKTVTCPHGCHTPLPTVYTNYPCGMRCPGGCGTFYTYRGWGAMLGRNLLLPFLAGAFGWMPEMPPLSPAVFAIYSEFRLHRGIFEIKGFEFIDGETSDLRLHYWTMGTLRRDYNTRKTTNAVLLLHGTAESGQDFVTENFAHELFAKYKALDARKYFIVIPDAIGHGRSSKPSDGLGTEFPRYRHEDTVNAVRHLLFARLGVNRLRLVLGASGGGLQAWNYATVYAGEVAAVMTLAATPVALSGRDRMWRKTMVAALKSDPAYNNGDYDGQPRKGLRLAISMCLMMTLSPGWFQERARTEQAADSLLKNLVDEELRKVDANDMLYQWESSWRYDIVNSYRKIRAHVNAINTEDDFINPYAARLLDRIMPEVPGATWYTIPVDRGTFGHRSYRNATIWQGHLWDVMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LNX4</accession>
    <name>A0A367LNX4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_2137</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LNX4"/>
    <dbReference type="STRING" id="1330021.A0A367LNX4"/>
    <dbReference type="OrthoDB" id="426001at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033550">
        <property type="term" value="F:MAP kinase tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017017">
        <property type="term" value="F:MAP kinase tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008330">
        <property type="term" value="F:protein tyrosine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043409">
        <property type="term" value="P:negative regulation of MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14521">
        <property type="entry name" value="DSP_fungal_SDP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10159:SF519">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE MPK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="325"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="430"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="65"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="142"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="596"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="726"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="77"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="179"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="608"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI16145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="758" mass="81787" checksum="5077D80682358B5C" modified="2018-11-07" version="1">MPSAAGRRMYEDQIPPLMSVYDIGAETIVHGDTVTLVDTTLVDLRSRVPILAKMTQPGIDVAMIPSGTAHSHHDSTSTHIFESTDSSPTTTMSTTDSSPLTDSSASSSPDSPIHLITLNNFPSTSFGRQPSYSAMHSIPELGALDRPMTSPAPRRPRNTKGLSIQPPAVLSKSVANTEPSSPSFIKPKIPTMRRKPSQLSLKTSTSDLGSKSSSEMPASPAMPPILRRRALKHSTSSPQMAALRSPAFGPPGGMTFSRVLERNESGLSEVLRPMKSDISMASGSDSSPPQNDSPIKTQLADRSDLECFKECANNEDQKSPGYPDGPMAIYDNVFLYSEPTMSEASQFDVVINVAKEVKNPFDAHTHARQSSCGSHVPETATSTASFATAFEFQPYDDTRSPSTPCTPTATALKRPEYLHVPWDHNTDIASDLTRLCEVIDSRTRQGKKVLVHCQQGASRSASLIIAYGLYRNPELSVNDAYYAAQAKSRWISPNMKLMYSLQDFHKQLTMKRLSPPSAYRQKAGRSPTKHRLTLSVDAIDVSKEPRTAPLPGEGDIMGDGYCPARRSCSISGSQTVPPGPASAPLTCSWSNGVEASPSLDDSTLDMLPRPDGKARNGSEAVRDESLGQLAATTASLPSRCRQPGSLAEMPAHREAFVGRHLIGAPSYPADEALMSPRAEAMTGNPIHSFSDVVDVRFMGCPATPVASLFSPRQAFFSTNPLSLFGRPTTFSRPSRRTDPRSPPARGETAITRSIDDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPD5</accession>
    <name>A0A367LPD5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2392</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPD5"/>
    <dbReference type="STRING" id="1330021.A0A367LPD5"/>
    <dbReference type="OrthoDB" id="1696305at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050896">
        <property type="entry name" value="Mito_lipid_metab_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46434">
        <property type="entry name" value="GENETIC INTERACTOR OF PROHIBITINS 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46434:SF1">
        <property type="entry name" value="GENETIC INTERACTOR OF PROHIBITINS 3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="635"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="641"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="697"/>
            <end position="709"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="852" mass="96591" checksum="D2F83FDA94EF0DF2" modified="2018-11-07" version="1">MSARAWKAQSRNSPEHEHITHAEESARQSRHVPVTCSGCGAFSQTTDPGRLGYFDVQSRRVRFWLHRNGGYGGAGEEDGNVSCDDASQQGLEEDVALDSNKKKRRSSKFEADKLVQQVLSSSSLGDDKLTALGLTPATMLSIADTQALYLNQIDSDRPPVCERCHDLKHYGASKDSAKLTVPCPSIDILEDTMAESPHRNHVIYHVIDAADFPMSMIPQLHTMLDGVYMRTRNRRSETSKYRRGRSIKMCFVVTRADLLAPKKEMVDRMMPYFRQVIRDALGDTACYLRLDVVCVSPMASWWVDMFRERLWNYRGASWLFGRVNVGKSRLFHEILPKHRNDVPVRCQEWSEPWSQVDKLLPPLQPERDWPELPLASPHRGTTVLPIRVPYGTTRFGHKSELIDMPGLERGDLAEFVKEEYRDSLLMRKRIVPEQFSLKSKNALILGGGLIRIVPRTDDLDFLLYNFTPMPPHLTSAEKAAEFQSEQRQARTVQNWMMPGTGEKIQHAGTFKLTFDVTKKRAGPLTRRGAVGLRVEKLAFRVLSIDILIEGVGYVEVVAQVREKHVRRYPLLEPDKFGKSSSGSGSGVGYDMMASRVEQKLGLSPWVGPHMRGSSRPLVPQKLGSVPWIEPRFGSRPPVKSHITENKAGEELCPRPSAKSSWVTEIKSGRELSPLATSWTTEIDSEKQTEPGSSDKSWVTERRSDEDVGSERPPGLTPTSNELFQKMGLEPPPEPVPKPPPGPITPMEFRQEMGFDDPEIAEEVPPWEHNHLVDWPAIDVYSPGGRFIGSRRPIHGWENNKPSRLLKPATARPRQSMKGRKCKSLHRFKTKMRHRYQDFKNADHIRHEGRIMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPH6</accession>
    <name>A0A367LPH6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Capsule polysaccharide biosynthesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_2820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPH6"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008441">
        <property type="entry name" value="AfumC-like_glycosyl_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05704">
        <property type="entry name" value="Caps_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI16310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="408" mass="45926" checksum="7B7D166AAE026D05" modified="2018-11-07" version="1">MSTMTYPLPEGVCAVAPERLDLRPDADIDTTLTTPQLVRDEKNIWFFWHDGFAQMHPYTQRTVRAWHRRFARQGWVVRVVNRKPGSPLNVAEFLDVEDPQTFPRAFTDGTIDGTYAAQHTSDLVRWPLLLRYGGVYADVGLMQIGDLDRLWNETVGDRSSPFEVLSYNAGGANDRNLTNYFLASGRDNPLFARSHRLLLALWADRTNTEGLHASPLLKGVPLMDASGMSFVEGGKTYGPDEISRMLGDYIVQGQAMSLVMGLVDEDDGWHGPKYVAEHVFAIDYKPGSQLINEMTAWNGPRQFELMSLTLPPAGQQESDDQKLARQIVEACLRRSFGFKLAHGLILRVMGDTLGSLWRKHQSADDVPGTYGHWLRHGIVYWCPKELPPRLEFQEIAPFKKGPLLGEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPM0</accession>
    <name>A0A367LPM0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BPL/LPL catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_2609</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the biotin--protein ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPM0"/>
    <dbReference type="STRING" id="1330021.A0A367LPM0"/>
    <dbReference type="OrthoDB" id="10250105at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin--[biotin carboxyl-carrier protein] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16442">
        <property type="entry name" value="BPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03144">
        <property type="entry name" value="GATase1_ScBLP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019197">
        <property type="entry name" value="Biotin-prot_ligase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00121">
        <property type="entry name" value="birA_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12835">
        <property type="entry name" value="BIOTIN PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12835:SF5">
        <property type="entry name" value="BIOTIN--PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09825">
        <property type="entry name" value="BPL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="3">
        <location>
            <begin position="388"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI16394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="676" mass="73304" checksum="2C0D42C05EA7358E" modified="2018-11-07" version="1">MAPRRLNVLVFTGKFPPSPFTSTGTSAESVRQCLYSLRRLLSADYAVTAVGDNALLKEPWPSTCALLVFPGGADLGYCRVFNGAGNRRIEDYVRRGGAYLGLCAGGYYGSARCEFEVGNPPLDVVGPRELAFFPSTCRGAAFRGFQYGSERGARAVRLRVNTALLDDASVPESFASYYNGGGVFVDAAADRSVHVLASYTDRLDVDGGSAAVVLCSVGDGNAILCGPHPEFAAVNLYPQPDIPGYADLINKLLADDASRVRFLRACLIKLGLQVSPQSASVPPLSHLHLSSSCNGSKVTDILGGWDDILIKEHGQDDVIRGEADTFLVRSRRRDSFSGDTLPELTIADDGHVDFSAVPKSIIAHEHDRPSPKSTPHFDHDFYYASLARFQAIEPDATDWGSVLLYGEVVTSTNSILEKSNSSLTSRLPTGFTFSASTQLAGRGRGTNAWIAPPGALMFSTVINHPGHLAVSRPPIFLQYIAAIAVVEAVQSLGTAYESLPVKLKWPNDIYALDPTKPASQRQYVKIGGVLSHCGYCDGQYQVVLGIGINATNPRPTTSLSDLLGAHTTAATAPLRLEVLLARILTRLEAVHAQFLRYGFSDDLEKRYYRHWLHTGQAVSLEAEGGVRARILGITRDWGMLRAEETDVEGRGTGKIWTLQSDENSFDFWKGLVRRKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPM2</accession>
    <name>A0A367LPM2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">L249_2454</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPM2"/>
    <dbReference type="STRING" id="1330021.A0A367LPM2"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45977:SF4">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45977">
        <property type="entry name" value="TARGET OF ERK KINASE MPK-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017009372" description="RING-type E3 ubiquitin transferase" evidence="15">
        <location>
            <begin position="33"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="16">
        <location>
            <begin position="393"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="343"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="374"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RCI16378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="546" mass="58454" checksum="5AD9A5D797D19554" modified="2018-11-07" version="1" fragment="single">MTVFVVFRRAFSSSAPLLIALVFFLCASLAAAAATTSAEKDVPLWASNNALQLTLSTKPGLQFTTIPLTENLGLNESDHVRGVVRIYGALKPANVSNYNQINGQDDIAYLSCDKPAGDNLINPDKMLNDLMAQRPKAILLYSTNRNWCSIDSTQPLAYTSILTMADAGEAGNVQGYLGGNNAAAAAVVNAIIQGNATEEQTVNNDSGAAGGGGNNSAVAMSILYSITGLITLLFLIIIATGAIRAHRYPERYGPRGAFGGRPRQSRAKGLARAVLDTIPIVKFGNQEPSKPDPQLELETTTTHMSSGAVKPQTKTLSRLPEIRPAAADTTGATTATTAIATTTTTTTTTTPPTAPRPRRYSQDSQVSALTVSDIEPEAAREEEDGVDNGNLGCSICTEDFCVGEDVRVLPCNHQFHPNCVDPWLVNVSGTCPLRLDLRPGHDSAGNGSPADDGEFLAPPLALEAEDGGGGGVRNSHGNRFSRLLDVNRLRQASVEERMEALRQMRTRNDEDWAAGRRAQGQSLTEKLKDRFRVRTRPQAAAERRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LPQ4</accession>
    <name>A0A367LPQ4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_3125</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LPQ4"/>
    <dbReference type="STRING" id="1330021.A0A367LPQ4"/>
    <dbReference type="OrthoDB" id="2043at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="entry name" value="30s Ribosomal Protein S19, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_uS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_uS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_uS19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_uS19_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="RIBOSOMAL PROTEIN S19P FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880:SF8">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US19M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="Ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="F-box" evidence="5">
        <location>
            <begin position="36"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI16423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="465" mass="52985" checksum="634E9BF4A189C6DC" modified="2018-11-07" version="1">MARKASIDKFLTSLSPWEIIYVRDALRSGKVSVQGLASFDDLPDELADPILCHLRLEDIFNCLLVSRGWWSKIKNEDVSRSLCKRFFPGLLNTETKPAPVLFLEAVRRYRQRRPHKAKRKRFIGWNTGWSTKTFSNPVQPVDDSSVRRDPSFDEERLIIRYKDGNLAWQPNPTTVIIDNLRTLNRLHCPLGRFIVSGQALRLIAVTRSLVVLGHSAMPNNHVFVFYTVSIWHMIDKKWETLSLPGDCWECFATDDRAAFATSEGEVFVWSWGSKTFSERIFTHSIVGNPSSDEMIVPFEGKLFKANNGLAWDDHLIISDRATSCYSRIFSAQYQAEDEFSNIANEVKVHACQFEVDAAGSSHDFTEGNDQPDSPSHICNTIRCIYDFSQRGTYHGTTGDAEYQGEKVPAVRTQARSATILPNFVGLRFEIHNGKDYESVLITENMVGHKLGEFSPTRKQHIWRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQ75</accession>
    <name>A0A367LQ75_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_2788</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQ75"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016586774" description="Secreted protein" evidence="2">
        <location>
            <begin position="27"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI16561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="79" mass="7940" checksum="A1300ED9537C3C6C" modified="2018-11-07" version="1">MTMTRPIVAVVAVVAVVAVVVVPCAAGRLPTYDRVINRREGGGAGAGAARRTGSLSPSSLPLPIRTVPVGGFTVPKAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQC6</accession>
    <name>A0A367LQC6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protamine P1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3298</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQC6"/>
    <dbReference type="STRING" id="1330021.A0A367LQC6"/>
    <dbReference type="OrthoDB" id="5419922at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="251"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="734"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="860"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="990"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1044"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="202"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="573"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="743"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="757"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="894"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="990"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1044"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1055"/>
            <end position="1065"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1065" mass="115063" checksum="EAFFCF7576FB266B" modified="2018-11-07" version="1">MALPMGNVIGDDEIFYHGSDDEDYPDPQTRQLRYRSAGERYLDNDIPFLLSASLRGPFDQLSGWDNPWKSRRRCEPCSIISTTLNSSKEKPKTDSVSRSGGKSTADSLQCHLPSPESLRQASVSEPHLFLQGQGLYMVQRWRQGIQPPSLTQDSFWASTNAQKNSSAKKRRAVESAWLKRRTNKKRKPNLIGRQISKKPALSSGDAGDSSPSSESCSSAFEASSPCRPRLVDSDDLIDQVELPTSTVNASFDGISTQVTPNKKPTSSSHCVSSSANGHLHGAAGEPPRQSEANVVTVSSPISRQSKMSAYVLGINKRKKRSPTPVTTKASLSPEEPSSGETTASDGDGWRQDARSIASKGTCRLQTQHDQSFCFKIRSAAEDAPEDQMLTSEPTQQPESPALAESGNQCRPPAIGLPDDVHSLEQRMTQSMSYEYLVRADKDGLRIKEAERPERHRMQSPQESTYGLLEHDGLAGDGSEAKKASSTISVEDKPLFTAPSGSSRAREESVTRCECRDGEETGPANNITSPPATAQHNMAANQQKDHDSELTPGPQEALESGPWLSGSRSALLPNHQSNTPTRPRQTCPMSPTDGTPQRYTLKLLLNHLVPASPWAKLSHLARSSGSTATWRGSQKINMGETEAVDESTQALISASQQSPWVGRTPVTNKTIVSFPEQIKDDADTEMSGCKAVDKDDVWVTGSQQSPWTALPPSTSLGQQQAAVESVLHEGLELNEGQGGELQDSKTTASQQSPWTETQSREPIDRVAARRSSPAGLSNQRCSGDDQRSCCYVGTENASMPALGLASSSPSIVVTSSQLQISRPHTPEPQFAVKPFASFITPSPERHPRALRSRACTMGGLASALKNPWSGNTSRPDRRVSWAPPPLQGDEERARTSSSLPSSTTSTPLPLPSAARSKARPVSPPPPLNNDSLPPSTKFSRHFAIAASRRRSLPSLASSPVLPCSTSKLRLIPTASQQGQTPGPRAMAEAFLAADDAATSEQQNQPQEPQQEAPLDGKDGVGVVDDLLRDMGDFFLAMDADAELDQAREDARASDPEFQTSAYQSPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQC7</accession>
    <name>A0A367LQC7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQC7"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="128" mass="14562" checksum="DA78F7B9017AEA41" modified="2018-11-07" version="1" fragment="single">MGGSRPAGRMGACGQASLGHDETDRAEKREPEPKPSGGKRQKEDEEEEENEEEEEEEEEEPNRDYYPYELDVSVQTQANQVKSKARQREATGHSMAWHGMAWRHGKEAKRNDRDVSSLAQTRRTETGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQD7</accession>
    <name>A0A367LQD7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2966</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQD7"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="231" mass="24787" checksum="8D0DD98159B39B1E" modified="2018-11-07" version="1" fragment="single">YNADSLYRSETRSLTLSLLSHSPTHDRQGEAKEKKGSPPLARPTQTQTHTHPFPAAAAPLPGQVGGLAKAEGVGEWVIVSSPSICLPPKLSLCAGRSGFHLPRTGYGGSLYHPISTCYLWLTPSYRPVGAADRCHVDRGKISLSSIHDPIHHIHIYSYTDGYPTTPSDAPILEPFIAILPPSHAIAVKLHVRPTHLIIIMPLTPNKAEIPNPILASPSPNPTDPCSVGHVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQF4</accession>
    <name>A0A367LQF4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_2575</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQF4"/>
    <dbReference type="STRING" id="1330021.A0A367LQF4"/>
    <dbReference type="OrthoDB" id="8120565at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF14">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="351"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="417"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="483"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="47"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI16641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="549" mass="60643" checksum="86AFC7AAF5E67182" modified="2018-11-07" version="1">MEKSKSSLSNDVNVEHQESSLIAETEQEPYGPSGIKGIFSSQYVAACACFSAIGGLLFGYDQGVVSVILIMDEFVARFPQVSEQAEGGGLMKGLVTAMITFGAFIGALNQGWIADAYSRKYSIILAVLIFTIGSIIQVSAVNYSMLVFARFVGGIGIGQLSMVVPLYISEISPPEIRGTLLVLEELSIVVGIVVAFWITYGTQFIESDWSWQLPFLLQIFPGILLGVGAFFLPFSPRWLASKDRQQDALTNLAKLRGLPTTDAKVQREWLEIVTEAKFQASILAERHPDLVGGTRTMKLKLEVASWIDCFKKGCWRRTHVGAGLMFFQQFVGINALIYYSPTLFGTMGLNVNMQLIMSGVLNVVQLVGVVSSLWTLDNFGRRKMLLAGSVGMFISHFVIAILVGLYSTNWPAHMDKAWTSVVSLLFYMLVFGATWGPVPWAMPSEIFPSSLRAKGVAISTCSNWINNFIVGLITPPLVQETGFGAYAFFAAFCFASFLWVFYCVPETSGKTLEQMDEVFKDYRTGDEQARRRRLMSETARDLSIRNGFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LQZ5</accession>
    <name>A0A367LQZ5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Heme peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L249_3299</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LQZ5"/>
    <dbReference type="STRING" id="1330021.A0A367LQZ5"/>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016702">
        <property type="term" value="F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031408">
        <property type="term" value="P:oxylipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09818">
        <property type="entry name" value="PIOX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034815">
        <property type="entry name" value="A_dioxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050783">
        <property type="entry name" value="Oxylipin_biosynth_metab"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903:SF11">
        <property type="entry name" value="ALPHA-DIOXYGENASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903">
        <property type="entry name" value="PROSTAGLANDIN G/H SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="13" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0925">Oxylipin biosynthesis</keyword>
    <keyword evidence="3" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7" id="KW-0611">Plant defense</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCI16652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="623" mass="70499" checksum="E0EAD8B8866FE1EB" modified="2018-11-07" version="1">MTDPLPKYRPSLLDRAISKAFSILNKVVPWYKLPSLLGAFNLAAIRNTMRENNLHDGYPPGRSPATASTEAEPMDERFINARNSDGKYNSLDMPRMGCAGMRFGRQFPREYCRKPTEEELWNPSPRLISERFMKRREKGFIPATTLNLLAAVWIQFQTHDWMDHEKVKCLYSWDIPLPKGDSWPGGRMELLKTKPDDVLDPSDEQTPGYKNINTAWWDASQIYGSDEKTTRALRAMDGDGKLAQMPGSGPISYDAAGVPRTGFVDNWWFGLHMLHSIWVLEHNAVCDRLREAYPEWEGTRIFDVARLVNCALMAKIHTVEWTPAVLGHPALQIGMNANWWGLAGETLTKMVGRLAKGETVSGIPGSKTELFGVPYSLTEEFVSVYRMHSLCPDNVALFNASTGKHHSTVPISDLLFDRAHEPFKKGVSLSDAFYSFGINYAGAITNNNYPKFMQALRTPDGQFRDLGTVDILRDRERGVPRYCQFRRLLNMSAPKTFEELTGDNRALAQELREVYGDIELVDVLVGSHSEPLIKGFGFSETAFRVFLIMASNRLKCDRFFADDWNEETYTPEGLHWVQNTTMKDVLLRHCPELGLALQHSKNVFAPWAKLPQSKAYGGVETNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LR09</accession>
    <name>A0A367LR09_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LR09"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI16827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="161" mass="17267" checksum="4DD4A9B4A4DB0EEE" modified="2018-11-07" version="1" fragment="single">MIAEDESWSEGDLFIVEALARARARAQAGGGEADGEAWVRAGLMRQTNGERAAVIDGTKNDEGGSGAGSAPSERPTWRRCATGESHATAALGRIIHARVLSGGGSVICRFAIASRSRPVEVISYEMGFDAADVGEGGGGRRRTRRRRKRRKKKKDKEKEKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRF9</accession>
    <name>A0A367LRF9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRF9"/>
    <dbReference type="STRING" id="1330021.A0A367LRF9"/>
    <dbReference type="OrthoDB" id="5146350at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="565"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI17033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="596" mass="67517" checksum="CEE6625FB26CA478" modified="2018-11-07" version="1">MSRLPALAGHVFLRGRNTFMGRGEEATDHEQLPQFLPRTEWPYHELANDMLRYTSSLESAINFQDEAEVRDLVARATPIYSQLVPMPPYHSVAYQLHDNVPWLAHVAILHDLIHRTMASHKPLSKDEMFALMRIVSYGMYHSVAWLYPWHIDLDSTGIPVGEWSQVFNMHMSAGDFRPTSMDHDAHIRRVYGRRWVVVPIRCGEAQWNMAMFDRSRGLLYVLDCGAAAARSDRIKACVELWVRFWNWMHLPYDFQYLAPAATGHASAMDSGLIAITWLMSSLRDQVGDVTAEDDDDDDDENKSPTRADFVFTRGDPNVGLEGGDLHPRDWLPDGCRLSSGGLMAVRRIVKVMICNELGLAYHETMTKKYRNHRGRQPAVLPSALMMIRHTVKKLKLRNGRLRTGRFWTAQGGPQFALPQRMMAGDYKEGAPRRHKRRPQQEFCLVETSTEGLTYRNRFVIHWPAAVPYTDEFPLSRPAHGVELETESLSAREDLDDAQTRHFEVTLANRAAEAAFRRMGQVQRVVLGKMRRDRSGGLLKLTLGVGFADEAVGHEVEMDVEMTIPADQTPTPPPPPPAGGDQGLATIGVYREGWGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRP2</accession>
    <name>A0A367LRP2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">VHS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_2727</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI16902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRP2"/>
    <dbReference type="STRING" id="1330021.A0A367LRP2"/>
    <dbReference type="OrthoDB" id="10068368at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14232">
        <property type="entry name" value="GAT_LSB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16980">
        <property type="entry name" value="VHS_Lsb5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044103">
        <property type="entry name" value="GAT_LSB5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038425">
        <property type="entry name" value="GAT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045007">
        <property type="entry name" value="LSB5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47789:SF1">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89009">
        <property type="entry name" value="GAT-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50909">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="5">
        <location>
            <begin position="18"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="GAT" evidence="6">
        <location>
            <begin position="214"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="145"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="324"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="191"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="354"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI16902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="413" mass="46422" checksum="664354F5FA527A5A" modified="2018-11-07" version="1">MFSQKKPYSAITVTVENLTSESYSVDDFSGIPDLVEVIKLQATGPTEAARAIRKKLKYGNVHRQLRALVILDGLIQNAGSNFQRTFADEPLLERLRVCGTSGLSDPAVRKKATELFREWSQYAATPGLERVARLYKELPKRKVTVTQDRSKAVKETENPFGDDEEREAEHGSEAPKAGPSASTQPLDFDKTKKKKKKEKHHRFGSSRKSFSIEAEKETMKSIIAEASIETTNLMNSLQSINRERQRISENRVAVQHFEACKQLRRRILRYIHLVDSEQWLGSLLHANDELVHALMSFEQLDRSVDADSDSDDELAEQAHLYRMHTGSHKSSSSYGGHTAPPPRALDLAGLTLNPPAKKPAAPSIPRPSDSTTGLRRPRVDQLKASEQEEDDDDPFSDNNVVGTPPFEREQPRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRT7</accession>
    <name>A0A367LRT7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_3244</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRT7"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI17070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="155" mass="16859" checksum="DCED068371A74CF5" modified="2018-11-07" version="1" fragment="single">METSQNRLPVACLSGLVPGHVPMATQPAHVGTTTDFAFFFCSTPCFDISRLHCFFLFVLLVSVPGAMFKSPGVEDAAVAVPFMCARCLLPEGEHGGKPKTGGRVEGGNTSFGIIKPHSRLHVAPDVDIDSDGYVRCILMEMPFIHPRRRRSEKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRT9</accession>
    <name>A0A367LRT9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NADH:ubiquinone oxidoreductase intermediate-associated protein 30 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_2814</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CIA30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRT9"/>
    <dbReference type="STRING" id="1330021.A0A367LRT9"/>
    <dbReference type="OrthoDB" id="426386at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010257">
        <property type="term" value="P:NADH dehydrogenase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013857">
        <property type="entry name" value="NADH-UbQ_OxRdtase-assoc_prot30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039131">
        <property type="entry name" value="NDUFAF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194:SF19">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08547">
        <property type="entry name" value="CIA30"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase intermediate-associated protein 30" evidence="3">
        <location>
            <begin position="22"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase intermediate-associated protein 30" evidence="3">
        <location>
            <begin position="152"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI17164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="287" mass="31297" checksum="BCC1967BF6842793" modified="2018-11-07" version="1" fragment="single">IWVLHHKHVYITRLTQKTLNRPWKATDWRASDDRVRKGKSHSYLTISPDGKTASFNGTLDTQTLGGAGFASQRTADEDLCLDLTAYDGIVVSVLAGDEQEPKPKTKKFALTLSDVKAEKSKAKKAADDDDDREEGSSDLATSRSASVQRDAAVLSWEAVFCAPVDDDKVVRLAWADFVPTYRGREVKGAKPLDLSRVRRVALMMRSFFGEQSGEFQLEIRSIAAYQTAVSPSRLGPAVTGNGRCGCDVDDALSLGDVAAGPRPSCRGRAGRLCCVMHVCLSFGEGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LRU6</accession>
    <name>A0A367LRU6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phospholipase C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_1867</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LRU6"/>
    <dbReference type="STRING" id="1330021.A0A367LRU6"/>
    <dbReference type="OrthoDB" id="5135119at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042578">
        <property type="term" value="F:phosphoric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16014">
        <property type="entry name" value="PLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007312">
        <property type="entry name" value="Phosphoesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956:SF1">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31956">
        <property type="entry name" value="NON-SPECIFIC PHOSPHOLIPASE C4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04185">
        <property type="entry name" value="Phosphoesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016578677" description="Phospholipase C" evidence="2">
        <location>
            <begin position="24"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI17139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="624" mass="69948" checksum="B24FF6D07F17553F" modified="2018-11-07" version="1">MATFSFTTHILFLALGALRPCSAGLADIDHVVLFMQENRAFDHYFGTMAGVRGFDDANLLTTNGVPVWKQLTSPKLTNDTHHLSPWYLNYLGGNWSEATQCMISGSNGWYENHAAWNEGSNDHWALNNTPWSIGYYKRHDVPVQWALADEWIVADMYQESVIASTSPNRVTWISGSINVPGSPQMPDQGGNPYIDNNETPGCESRGINCYPLKWKTAAEHYEEASVSWQVYQDADNFDDNPFAWFKQFQDAKPGSSLHSRGVKGLSLDTFYAQAANGTLPEVSYIIGPTELSEHAPYSPHDGAWLERKMVEAVIKSPRYAKTVLIVSFDETGGWFDHVDPFRAPRGTPAEWLDDPYGQVGHTFAGPGFRVPMYIISPWTRNGGVYTDHADHNSQLLFIEKWQASKGRNVTTNEMVPWRRRNMADLVAAFDFQNPDYTVPELPPAPEPHRNKNDVYDGSSHCQSLFSHPQPPVPYREEDSRPEMSSLVEPGFKPMRGRLTEGRFLVLEMDGYALTAIPSVKRAFLTRSTKSHSEPRHRWVAHALKQGGHLFTLRSSSSGPFLCCGDEAELCADPKKATVFVVDFEPSKGYSLRVEKTGLYVTAARGAVSLVEDVGHWKFYAVSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LS35</accession>
    <name>A0A367LS35_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Subtilisin-like protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_3198</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LS35"/>
    <dbReference type="STRING" id="1330021.A0A367LS35"/>
    <dbReference type="OrthoDB" id="19448at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF58">
        <property type="entry name" value="ALKALINE PROTEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016958692" description="Subtilisin-like protease" evidence="8">
        <location>
            <begin position="17"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="10">
        <location>
            <begin position="44"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="9">
        <location>
            <begin position="146"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="155"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI17170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="839" mass="92274" checksum="F5A158FDBC7FF6B8" modified="2018-11-07" version="1">MHFSLLLRSLPLTAAAGLSFPPSKHHVPASLHRSVRSSSTIPGKYIVKFKRDADPSMCHNDTHIKLSGETDHVYQGQFSGFARSLDEQQLDYIRHHHCVEYVAEDQYMTASSVVENPALSWGLVLLSHNTSDYQNYNTYVTDDTAGEGTCVYVLDSGVDDSHPEFEGRAKQIKSFIPEAKRDVCGHGTHVAGIIGSKTYGVAKKTNIYGVKILNDTTSAAEKSPVSAAIAAFDFVAKDRASRKCPKGVLVNLSAGCNGAVVKALDDAAAALVDQGVFVAVAAGDQRMDAAETSPGSEPSVCVVGAVYPLNRIDSSNHGPRVDVFAPGVSFSLKPGGGIELMSGTSVAAPFVTGLAAYLAALEGLSGTAALCRRIRELSNKDAIRHLPSGTGNRVVFNGAKPEEKIKLPTRHDRDGEVSPIKKGLLHLRLMEFYIASLTSSVFVCENEGFRQPCAWVEAPEKQCVALPDQFLNKVSSLDSTWFAGTCRFYDEAGCQGGSFQAAYSAYSDQGVNLTSEDSRGLGIFNNRLKSLQCDGEPITYSEDPHSLDGWVWSPQTQKNTCSRLDRLYVDFRASSGSDDGTLDTLRLEFVGIGERPHVMIEAPAAGFHGWQPVDLKSVFGYETIDVGRIRQLRINATQTTWRGGDPWGLSSIGLIGQCDESKVLVNNHRFASINRRLSFHHAVRHLAWNRYTAWEGYTGPEDWAPDLPCSHFEPLEVYLETANEYSAGTDNAIYVKMGKIRRRIAERLWLGQTYNLTIQSEDGRPPKPIPVALKDVDYVEFESDGGYDQVKLASELAKMIRMCAGIERKFRVEREIDEWIADKGKWGFRLNSSDWREYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LS81</accession>
    <name>A0A367LS81_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit gamma</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_3234</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LS81"/>
    <dbReference type="STRING" id="1330021.A0A367LS81"/>
    <dbReference type="OrthoDB" id="10250549at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04652">
        <property type="entry name" value="LbH_eIF2B_gamma_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051960">
        <property type="entry name" value="eIF2B_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056764">
        <property type="entry name" value="LbH_EIF2B3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25084">
        <property type="entry name" value="LbH_EIF2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EIF2B subunit epsilon/gamma LbH" evidence="10">
        <location>
            <begin position="432"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="308"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="310"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI17303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="561" mass="60771" checksum="BF8B56885FA89B31" modified="2018-11-07" version="1">MPHALSMPATGLQAIILCGPGSSLSTFTSNPDENPKALLPIANRPMVWYPIDFSLRMGVTAITLICPPSASLALTTAFNTNPFLTGLPLPRPDILAPVSLDQNTGTADILRMPEVRELVKSDFIVLPCDLVCELPGEKLLQAWMVKAASLTQLLGIVNFSSGGHARHSGGLGVWFNTKAASTTRVKGEETDFIATAPLPRPPTAAAKESVFPNLSKLVYSVPTDSLNDITEEKKAVPIRKSLVRKHPRIRVYATHRDAHIYIFPRWILDFVEENDRLHSIGEDVVGWLAKAGWQRGLAGKLHLDTLLRDQPTNGDSSSTPDKAATSREASPVSDERPARWALVRTVTAEVRRAEAKRNASSECPVPPMVAYVHPSEGKQSELLIRRVDTPQLLLATSLQLAKLPSVEESGMDGASPFAHARKVAYPEGVKPRTTITKQDSVIGDNVTVEEKTSIKETVVGANCQIQEGAKLWQCLLMEGVVVGKGCKLSKCILGRRCIIGEGTVLTDCEVQDNLLVEAGTEDKNNKLMSSEGLEATEDEVNELLQQEGEEIAVATDEAAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LS87</accession>
    <name>A0A367LS87_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_1806</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LS87"/>
    <dbReference type="STRING" id="1330021.A0A367LS87"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="18"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="4">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI17102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="310" mass="34040" checksum="C5B1F1E53CAA1643" modified="2018-11-07" version="1">MPAITSFKLNTKADIPAVGLGTWQSKPGEVQSAVSYALQNGYRLVDCAYCYGNEDEVGEGLKTAFSAGVDRRDVFVMTKVWATYNNRVAEGLEKSLKSLGLEYVDLYLIHWPVLMNPNGNDEKFPTLPDGSRDIIRGWNHVEAWKQMEALLATGKVKAIGVCNYSKKYMEELLAQCTVVPAINQIENHPSLPQQDVVDFCKSKGIHIVAYSPLGSTGSPLMSAEPVVEIARKKGVSAGTVLLSYHVARGSTVLAKSVTPARIKANLDIVDLDAGDMKLMDDYSAELVKKGELKRYVKPAFNVDFGFADKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LSA2</accession>
    <name>A0A367LSA2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_2633</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LSA2"/>
    <dbReference type="OrthoDB" id="4914334at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.15.10">
        <property type="entry name" value="Proaerolysin, chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI17240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="466" mass="51648" checksum="D35088CDAAD6FF28" modified="2018-11-07" version="1" fragment="single">MYDSSAADETLGQGTHSLTCSLFPASIYNYGPSLALVPLHMSSRLFLLVIPYAQVGIEPRQSRSVDITEMIRGTPQGNRGVDGWKDMAAGRHIPYSEAALTSAEGARDFMKLVPEAGRKCFHLRYTLLGEGQTELDIGKAYLDHDFGGPATVSISTSHSHIDSSRVGWNREDASEMGSTMSASLSANLLGLVSAATAWTVSGSHRWSSAESGDKTTTQEETKTVAYQVTCPDDSSCKVVTWTYIKTTRGRCGRIPLVELDCITSSHSGWPNASVLALASLDGYHFPWALPIAQKYWHLPKLWPAHGLPQKGDVIMHQDHPDLLNKFDAPCSFSYPLYTASGKPVSTQDMLVYKRGYDNSPPPTPSRRFTARGWNYDENVCELEHDWVFTVSREGAFYGRAEPKEWFLQKRRPNWPLFPDGLYDKCRFLAEAVDNITKAVSRRSDDDMYLDKVVVLDDDLGNMPGTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LT10</accession>
    <name>A0A367LT10_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_2937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000001">
        <property type="protein sequence ID" value="RCI17460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LT10"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="421"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI17460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="456" mass="50781" checksum="71BF71676DF87039" modified="2018-11-07" version="1">MKKKKGFLVWTAGGHARVFFFFNPRDGVLPVVNELVTKERASGLILLLLRPVGSSNESSLTLVLSVGGKVCRVEGEKGCNYLLNNPVPGLGWGGEGLGSTYKVVPHLRPTLELRHLTHLLQEDEAKSVFETPISSFPLPSSSSSLHSLGRCSSDHRTRLWTLTPLKKKIPDSSGLRIHPASGRWRDVADLCQASHSILFQHFFFFFRFFPADGKQKAREERAERAPAVAETAIPLCLSLGTARCRSPAVGGQRWFVTCRPQQERRKQNKQNITKQNKMEDKVSIGQESAVGLVGGTTVDFSHLSGSWKLSLALAPANLPRQQPVWYDLWSIHCERGVLIRQGTNSCSISCEITIGERQKDHIHIHTYLRTVEADLYARYEQVQPLSYTYIRKAPIDKSTMNPICKARTYQSKTARLFFPKATGSIARHKPPPPSTRRRGRDTPTGQAAVSLDVAPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L058</accession>
    <name>A0A367L058_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_5793</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000023">
        <property type="protein sequence ID" value="RCI07815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L058"/>
    <dbReference type="STRING" id="1330021.A0A367L058"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="3">
        <location>
            <begin position="239"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="1">
        <location>
            <begin position="239"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="40"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="313"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="69"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI07815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="337" mass="38146" checksum="3B4B8D461BFA30ED" modified="2018-11-07" version="1">MFVASLHRVVARRALPSGLNSIAARRLVLARRAFSGSSWLRDPTTATAKKEPATKKATKKATASSSAKAKAKAKPAAKKKKAPAKAKKAAAAPKKKKKKAAPVKKKKKPTRKPRKPLTPEQREKIKLRYLKMVSLYKGPDTRAPQPWPLYVAENISTVSNPDRRVKLNDLFARYSKLPAAEKQSLEARANANREWNKREAVRWAKSYPIEVIYLANIARRRLIRITNKVRNYIHDDRQPKRPAGAMARFVRDRHDKTSGADQREVLKNVVNVWKGMSEAEKKPWLDQAEAEKARCKGQFDNFLAKAKQYWFNNKPKRRPTVPKIHSPSVTAKAKQAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0J3</accession>
    <name>A0A367L0J3_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_7806</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000022">
        <property type="protein sequence ID" value="RCI07950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0J3"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI07950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="86" mass="9577" checksum="58E8F17FED007C7E" modified="2018-11-07" version="1">MPAAISLFDTPKIIQDLPRMQVRVSSLKSPIMLALLDTSAKTNILTASIARDLNLEYRPIQTTTSNLYARYLFGSTRIVTLVARPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0P6</accession>
    <name>A0A367L0P6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000022">
        <property type="protein sequence ID" value="RCI08005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0P6"/>
    <dbReference type="STRING" id="1330021.A0A367L0P6"/>
    <dbReference type="OrthoDB" id="5336357at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="187" mass="20623" checksum="91BF7CDD318A7849" modified="2018-11-07" version="1">MVKRKRSIPTLRSTESPTGHDVELRTALNSRTLKRVRDGRPSDDEVHQRTLAILYSAQQREQHSVQESEMQITTMNTTTTTTPPPPDADHDRQRTLHRYWNIASSPSSCASSSPPQLDRSMKRIELCCVDCGAGLTDKAGETTMQPACLACGKHVCLGCSYSQLGENRHCLQCVGGACSNDTSVMVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L0W5</accession>
    <name>A0A367L0W5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptide hydrolase</fullName>
            <ecNumber evidence="3">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_7845</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000022">
        <property type="protein sequence ID" value="RCI08051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L0W5"/>
    <dbReference type="STRING" id="1330021.A0A367L0W5"/>
    <dbReference type="OrthoDB" id="3907302at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016603">
        <property type="term" value="F:glutaminyl-peptide cyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03880">
        <property type="entry name" value="M28_QC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037457">
        <property type="entry name" value="M28_QC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040234">
        <property type="entry name" value="QC/QCL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056790">
        <property type="entry name" value="Ribophorin_II_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12283">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12283:SF6">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25147">
        <property type="entry name" value="Ribophorin_II_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016487825" description="Peptide hydrolase" evidence="3">
        <location>
            <begin position="22"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="542"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="577"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="610"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="5">
        <location>
            <begin position="113"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="domain" description="Ribophorin II C-terminal" evidence="6">
        <location>
            <begin position="532"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI08051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="640" mass="70290" checksum="CCF0A2D965B83251" modified="2018-11-07" version="1">MLLRRALLTPVALSLARMAQLADDDLRRVPGPGDDFDSKLLGPILIPRVSGTDGSEKVQRHFVDFFAANLPDWKLVWQNSTSKTPVTGDRDVPFSNLIFRRDPPGATVGRFSRLTLVAHYDSKYKPDNFIGATDSAAPCAMLLHVARAIDAALTKKWASDDVGNEQGVQIILLDGEEAFLTWSDNDSLYGARALSAEWESTLNPPLSVFRSWLDSISLMVLLDLLGSKDPRVPSYFSPTHWAYQMMANVEMRMRSLGLLESNTSQPFLPDNDTMSAGHGGISDDHLPFMHRGVPILHIIPSPFPTVWHTMADDGEHLDMATVRDWAKIVTAVDLIVEPPSKRTVPEFKFILPSMIGATISHSATSTTYYFSRAAKYHLWITDSFIQLASTSSLPALYDAFSSSKKASDAITLGPKDTIKVSLKILDQEAKAKRPAQALLIVRESSGLEVDFPLTVKQSGKGTVQFSHKDLPTQMLHVKRPLQASLVLGSSGTTPGSVTPVFDVNLMLDPASTTPSHEATLRYLQLPDIVHTFRADPKSPPRIVSLAFALAVIASVPTLLVTWFLFEANIRHAVKAISRAPLSHVIFFGSVVGMEFVFYRYHSGWNLFQTLPMAGLVGVSAFLSGTKALGEVQGRRMAGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L121</accession>
    <name>A0A367L121_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000023">
        <property type="protein sequence ID" value="RCI07912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L121"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI07912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="112" mass="12127" checksum="4482D2D56F298BAB" modified="2018-11-07" version="1" fragment="single">MFVRPATTSRVLSLHVSGTPSRTCFANNRRGRLAPWSGTSRGVSRYPAGIATLTPLPSNPSPPFPPDPVRRPGSILAQSTTSVSQSLSTLYGYISTSLRLDTWYPAQGRLPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L149</accession>
    <name>A0A367L149_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_6229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000021">
        <property type="protein sequence ID" value="RCI08148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L149"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="119" mass="13497" checksum="CE5DC812CAC895F3" modified="2018-11-07" version="1">MRTKKDYIHCYTAYSGVGSIGLTRTSLPPNHQSSKYVRVLQVGTLKYLEKIISISFSHLLNTNTSPASNSSSIASFRLSPRVQLSDSGYLYTFNLFFTAFLFTFRPTNYLIRTLFSDAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L271</accession>
    <name>A0A367L271_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cullin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_8903</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11 12">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L271"/>
    <dbReference type="STRING" id="1330021.A0A367L271"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000014">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000007">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000011">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000026">
        <property type="entry name" value="Cullin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.130:FF:000003">
        <property type="entry name" value="Cullin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000029">
        <property type="entry name" value="Cullin homolog 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016157">
        <property type="entry name" value="Cullin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01256">
        <property type="entry name" value="CULLIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0832">Ubl conjugation</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cullin family profile" evidence="13">
        <location>
            <begin position="417"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00069612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI08529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="772" mass="88996" checksum="218E5DFF769F4A90" modified="2018-11-07" version="1">MAARMASPSQMPQVPNREDIRATWNYLQAGITHIMIDLERGIDMQMYMGVYTSVYSAVHNFCTSQKSVGLTGGPAMHSGHRGAHLLGEELYNNLINYLRVHLEHLVDESRLHTEEALLTYYIKEWQRYTTAAKYIHHLFRYLNRHWVKREIDEGKKNIYDVYTLHLVQWRKVLFDRVSSKVMDAVLKLVEKERNGETIEHGQIKSVVDSFVSLGLDEADPSKSTLDVYRYHFERPFLAATKEFYQAESKQFVAENSVVEYMKKADARLAEEDERVNVYLHQDIAVSLKRTCNVALIADHATLLREEFQVLLDSDREDDMARMYRLLSRIPEGLEPLRAKFETHVRKAGLAAVQKVESCEGDKLEPKVYVDALLEVHSQYQLLVKRAFNDEAEFTRSLDNACREFVNRNVVCKSSSSKSPELLAKYTDVLLRKSSTSIEEADLERTLSQIMIVFRYIEDKDVFQKFYSRMLARRLVHSNSSSDDAETSMISKLKEACGFEYTNKLQRMFQDMQISKDLNKEFSDHLAGIGSAPSIDSTFSILGTGFWPLTPPSTRFHPPAEIATEINRFARFYKHKHDGRKLTWLWHLCKGEMRTSYCKSNKTPYTLQVSIYQMAILVLFNEKDTQTYEDVASATQLSSEVLDQALAFLLKAKVLLLSGDRPGPGKTLSLNYDFKSKKIRVNLNIGGVKETKQEEAETNKTIEEDRKLVLQSAIVRIMKARKRMKHTNLVSETINQIRARFVPKVGDIKKCIEILLDKEYLERLDDDELGYLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L289</accession>
    <name>A0A367L289_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="19">Peroxisomal hydratase-dehydrogenase-epimerase</fullName>
            <ecNumber evidence="5">1.1.1.n12</ecNumber>
            <ecNumber evidence="6">4.2.1.119</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Multifunctional beta-oxidation protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">L249_8902</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Second trifunctional enzyme acting on the beta-oxidation pathway for fatty acids, possessing hydratase-dehydrogenase-epimerase activities. Converts trans-2-enoyl-CoA via D-3-hydroxyacyl-CoA to 3-ketoacyl-CoA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a (3R)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32711"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="1.1.1.n12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:26526"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:57319"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="EC" id="4.2.1.119"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.n12" evidence="5"/>
    <dbReference type="EC" id="4.2.1.119" evidence="6"/>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L289"/>
    <dbReference type="STRING" id="1330021.A0A367L289"/>
    <dbReference type="OrthoDB" id="3592703at2759"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018812">
        <property type="term" value="F:3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03448">
        <property type="entry name" value="HDE_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05353">
        <property type="entry name" value="hydroxyacyl-CoA-like_DH_SDR_c-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000410">
        <property type="entry name" value="Peroxisomal multifunctional beta-oxidation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000013">
        <property type="entry name" value="Peroxisomal multifunctional enzyme type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000185">
        <property type="entry name" value="peroxisomal multifunctional enzyme type 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054357">
        <property type="entry name" value="MFE-2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051687">
        <property type="entry name" value="Peroxisomal_Beta-Oxidation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45024">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45024:SF2">
        <property type="entry name" value="SCP2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22622">
        <property type="entry name" value="MFE-2_hydrat-2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14" id="KW-0456">Lyase</keyword>
    <keyword evidence="15" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ketoreductase" evidence="22">
        <location>
            <begin position="315"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="594"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="21">
        <location>
            <begin position="600"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00052025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00055743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00073871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00081853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="RCI08528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="921" mass="98121" checksum="E15DAF6484A85628" modified="2018-11-07" version="1">MVEQLRYDGQVVVVTGAGGGLGKAYALFFASRGASVVVNDLGGSFKGEGNSSKAADVVVDEIKAAGGKAVANYDSVENGERIIDTAIKAFGRIDVLLNNAGILRDISFKNIKDQDWDLINKVHVRGSYKCARAAWPHFRKQKYGRVINTASAAGLYGSFGQTNYSAAKLAMVGFTETLAKEGAKYNILCNVIAPMAASRMTETVLPPDVLENLKPDWVVPLVAVLVHKSNTTETGGIFEVGGGFAAKLRWERSGGLLLKADDSYMPGAILDKWNKVVDFSNPQYPSGPNDFMTLLEESMKMSPSPKAAKLDFSGRVALVTGGGAGIGRAYCLAFARHGASIVVNDLADPYKVVAEIKGMGGKAVGVKASAEDGEAVVKAAVDAFGRIDIVVNNAGILRDKAFNNMDDNLWDPVMNVHLRGTYKVTKAAWPYFLKQKYGRVLNTTSTSGIYGNFGQANYAAAKCGILGFSRALALEGFKYNIYVNTIAPNAGTAMTATIMPEEMIQAFKPDYIAPLVLALCSDKCPDPTGGLYEVGSGWCGRTRWQRAGGHGFPVDVALTPEEVVKNWREIVDFDDGRADHPEKTQEAMGKIMANMDNRRGGGGGGGGGGGGGGGGSSSSSSSKAVNRHLEAIADAVGKEGNPCEFKYEEKDAILYNLGVGAKSSELKYVFEGHDDFQVLPTFGVIPPFSTELAFDYDAIVPNFSPMMLLHGEQYLEVRTWPIPTSARLVSRGKLVEVVDKGAAAVVRNAITTVDAHSGRDVFYNEMTVFLRGCGGFDGQSKAKDRGAATAANSPPDRAPDAVVEEKTSVDQAAIYRLSGDYNPLHIDPSFAKMGGFKAPILHGLCTFGIAAKAVYDRFGPFRNIKVRFAGPVIPGQTVVTEMWRHRDRVVFRSAVKETGKPAIAGAAAELMPGSGGGSSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2A0</accession>
    <name>A0A367L2A0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Longin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_8830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2A0"/>
    <dbReference type="STRING" id="1330021.A0A367L2A0"/>
    <dbReference type="OrthoDB" id="18320at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006722">
        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12403">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI08559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="19542" checksum="C190815F5824E1B8" modified="2018-11-07" version="1">MTTAIPSIACLGVLGRNNNPLHISIFPSHDPATDRFEPIRTPLQFSLLLSSTVDVLELRAKRNAAANVGLSGDVGLLHAVDDRLAAYGFETNTGVRMVCVVDMRGRRVTGGVDGGGLRDGELKPVFRAMQAAYVKLLQNPFYDPDEHAPLGGKGGRQISSRRFVEDMRKIGEGWTPGVTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2H8</accession>
    <name>A0A367L2H8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_8970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000019">
        <property type="protein sequence ID" value="RCI08422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2H8"/>
    <dbReference type="OrthoDB" id="3886346at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="399" mass="44396" checksum="5532D2B1A4D0CD34" modified="2018-11-07" version="1">MPARCLCAATTETAISREDDYRDTAMDALVFLVSNIPDWLRQLDDLSGQIDRRQAELAAFNAQQPPGSRAVSLRNKGSAESLKPKDDGPLHMDVEIAQQSQEFEAIPSEHEGADLLALQKKAREAVAAAHPRARPLARNRPMPVSAVSAEGAPSTYPMRSMVLVYYDSYVQGFFDSLVRFVSSSRNHLRKARMTAKVAHIKRMAEREMRDDDQADGEDKTAPGSLPSLRYIATTRRASAMSAARKSESDNQPPDIFETLDKGLELVQSTCEHGAHQFLREANCEAEIRKIQARMSEVVAAAEKEIERIRHQGPDETGDAARASRTRRPISIRKDTSKSEMESEKEAHVASETLDQTVESVVEAVNPLEVDTSEDPDEGVDVMLPKLQYRSTRYMRTRAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2N5</accession>
    <name>A0A367L2N5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8035 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_4664</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2N5"/>
    <dbReference type="STRING" id="1330021.A0A367L2N5"/>
    <dbReference type="OrthoDB" id="5410752at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058348">
        <property type="entry name" value="DUF8035"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26118">
        <property type="entry name" value="DUF8035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8035" evidence="2">
        <location>
            <begin position="445"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="138"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI08667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="557" mass="65435" checksum="BBE1F35755469110" modified="2018-11-07" version="1">MAHRNSRATDFEERDYYSAPRRQPPADLDERDYRPRAAPRSRVAQSEYDEVDIRLRDREMDRTPGFLRDDGRRPEAGPMVLRQREVETIDRHARSPSPVRRREMARRPKSISPPTMRGTEREHSHTRIVERERDRVRSPSVVRCRSPSPLPVRFVERRRRSPSPVSQHEHIRIVERDRQRIPSPSPSPSPPPPVIRAPTIEREVITHWTNIDHGKHRGPPTASDLTDLLEGVVRVKPPSPPPPPRSRPKERETDIDISLSKNRTEVDVHQSTSRPRSKSRERRSRYHDDELVVRRDGDRLRVEEYSGPRRRAHSAAPACSPAEEEAEYLTSKIDSRGRMGEAWGGATREWGIVDVPPGTERVRMEGVGGATTDTTWSRYSGVRRTQFNPERDGTLVPREPSPAPSRGDRGSAGVYDREREIDVDIDRRVTRTPQPPPPPAPPARDLWTEITKDLVVREAIEQLGYEYEETKVHFYIPDYLQYEDVVRLTNLSEDIRRARKERVREIQWERDEWERPFRRHMNDHYDHWRSREEWDDERVRERDVVYDSHRPNRGYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2Q2</accession>
    <name>A0A367L2Q2_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Elongation factor Tu</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_4810</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2Q2"/>
    <dbReference type="STRING" id="1330021.A0A367L2Q2"/>
    <dbReference type="OrthoDB" id="2067at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01884">
        <property type="entry name" value="EF_Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03697">
        <property type="entry name" value="EFTU_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03707">
        <property type="entry name" value="EFTU_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000001">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000003">
        <property type="entry name" value="Elongation factor Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_B">
        <property type="entry name" value="EF_Tu_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041709">
        <property type="entry name" value="EF-Tu_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050055">
        <property type="entry name" value="EF-Tu_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033720">
        <property type="entry name" value="EFTU_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004541">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_bac/org"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004160">
        <property type="entry name" value="Transl_elong_EFTu/EF1A_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00485">
        <property type="entry name" value="EF-Tu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000766">
        <property type="entry name" value="PRK00049.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009372">
        <property type="entry name" value="PRK12735.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009373">
        <property type="entry name" value="PRK12736.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721:SF36">
        <property type="entry name" value="ELONGATION FACTOR TU, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43721">
        <property type="entry name" value="ELONGATION FACTOR TU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03143">
        <property type="entry name" value="GTP_EFTU_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="53"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI08711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="445" mass="49216" checksum="7583867D4D3E6A9A" modified="2018-11-07" version="1">MSRSIRTVAPLLRTARHCLANGRTDPFCSTVGKHNATGILNILRTYAVYERTKPHVNIGTIGHVDHGKTTLSAAITKRQAEKGFANFLEYGAIDKAPEERKRGITISTAHIEYSTENRHYSHVDCPGHADYIKNMITGAANMDGAIIVVAASDGQMPQTREHLLLARQVGVQKIVVFVNKIDALDDPEMLELVEMEMRELLTTYGFEGDETPVIMGSALMALNGQKPDIGEKKIDELLKAVDEWIPTPERDLDKPFLMSVEDVFSIAGRGTVVSGRVERGVLKRDEDVDIVGKGTDIIKTKVTDIETFKKSCDQSQAGDNSGLLIRGIRREDIRRGMVICKPGTVKSHKKFLASLYVLSKEEGGRHTGFRQNYQPQIYLRTSDESVTLNFPDGTEEVHSKMVMPGDNVELVGTLVYPNAIEVGQRFNIREGGKTVATGLITRIVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2R5</accession>
    <name>A0A367L2R5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">O-methyltransferase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">L249_4763</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2R5"/>
    <dbReference type="STRING" id="1330021.A0A367L2R5"/>
    <dbReference type="OrthoDB" id="2410195at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF16">
        <property type="entry name" value="O-METHYLTRANSFERASE ELCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="5">
        <location>
            <begin position="307"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RCI08716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="502" mass="56242" checksum="41358D6B599CB5B3" modified="2018-11-07" version="1">MGKFKVPSWLLPMSSSNKDKQNRRSFSGFSHRRVKSDDNNNKPSRMMELAAKITVETEKLNRYVRDNGLPEPGFDVDAPDSFPPLPAELQTSRLEVVCAAQELESLVRGPRENVRWAVWSVRFQSISGLDFTETNKYLNTLSLQIINKYGIAKLVPVDGSSAVSLSQLQAKTKLDPTNLARVLRHAMTNHIFCESSEGEISHTAASRLLAQDESLQDWVGFNSEEVFPSAAQVLKALEAHPEATSLTMTGFNFAFDTVGTEPMFVTLGRDPTRAKRMGGAMASLSAGEGYEPRHFVDGYDLSDVDRRGGGVFVDVGGSHGFVCVELARRWKGMTFVVQDLPQTVDSAPVPICEDPSVAARIRMQKHDFFEEQPVKGADVYYYRWILHNYSTPYAVKLLRNLIPALKPGARVVVNEHCLRAPGAEKPWDERLIRGMDLVMMIACNAQERDEEQFRQLFREADERFVFKGVTRSDDCRMSVVEAVWEPGLVRMNGRGEDEDVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L2S3</accession>
    <name>A0A367L2S3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_4682</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.9" evidence="1"/>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L2S3"/>
    <dbReference type="STRING" id="1330021.A0A367L2S3"/>
    <dbReference type="OrthoDB" id="4755094at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003839">
        <property type="term" value="F:gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009288">
        <property type="entry name" value="AIG2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017939">
        <property type="entry name" value="G-Glutamylcylcotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935:SF0">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06094">
        <property type="entry name" value="GGACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-glutamylcyclotransferase AIG2-like" evidence="6">
        <location>
            <begin position="12"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="236"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI08731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="267" mass="29353" checksum="37022949567EAE35" modified="2018-11-07" version="1">MASSSSSSSRYYFAYGSNLHMEQMKRRCPNSRYVGRAELPDHRWQINDRGYANIVAAQGHHVQGLVYEIDAADEARLDLCEGVATSAYQKRHLPVLLHRALGPLYRRPVSWIVAKGGPDAVCRAAASVAASPPPRQLPVPDVLVYVSFHHVQDSAPRHEYVRRINLGIADARILGIDDDYIQKSIRPFIPEPPAGDGPATSVGALVFVARPSSTVKDLLVDRLGVEIVHLNAIATPCVSQPPPPPPRPQIYYGPSPPPPRRKLSRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L308</accession>
    <name>A0A367L308_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L308"/>
    <dbReference type="STRING" id="1330021.A0A367L308"/>
    <dbReference type="OrthoDB" id="4775454at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="255"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI08813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="413" mass="46011" checksum="9F1DD02710C61924" modified="2018-11-07" version="1">MHHMGKPVLVLATTNYHHPTTSRHHHNYSYPRHDAGGVGSGGAAAAAGGGRGIGIGPPPRSLPLSDDRSSLGSATDDDEASDDDYRYHAHAAELWDSFWKRKEEDTMQLLQQQRLYHHHPLPCLPPPPSLPRKKYPALISSPRRSAVYQTTTSSWPLADSRSRKPAASYVQPASPPSPAAYSIFPPSPPQPSFSPVSAPAKVFPSRRPWDEVVTPCIRVVTPSSSCSSSPPGYKPPPATTPTMNWHPFPPRTSSNNNNNNNNINRPRTSHGTPSSSPHPFHQPTHQQQREPRHHKSMAHFPTPPPRPAPPPPREPEPHSVFESDSDDSDSDHGRSFFRFHRRNDSDHHHHHHHHHHHHHHHRRSAKHPSPPVPPSPAKSSRPMTAPSFADISNSSRLAKQQRKLGRMLGRRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L312</accession>
    <name>A0A367L312_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Myosin type II heavy chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_4679</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Binds to cdc4 and rlc1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367L312"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120104">
        <property type="term" value="C:mitotic actomyosin contractile ring, proximal layer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902404">
        <property type="term" value="P:mitotic actomyosin contractile ring contraction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01377">
        <property type="entry name" value="MYSc_class_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.530:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.720:FF:000001">
        <property type="entry name" value="Myosin heavy chain, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000101">
        <property type="entry name" value="Slow myosin heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.360">
        <property type="entry name" value="Myosin S1 fragment, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.270.10">
        <property type="entry name" value="Myosin, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055914">
        <property type="entry name" value="DUF7491"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008989">
        <property type="entry name" value="Myosin_S1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF857">
        <property type="entry name" value="MYOSIN-11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24319">
        <property type="entry name" value="DUF7491"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02736">
        <property type="entry name" value="Myosin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5 9" id="KW-0518">Myosin</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="13">
        <location>
            <begin position="108"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="12">
        <location>
            <begin position="162"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="9">
        <location>
            <begin position="733"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1113"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1343"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1551"/>
            <end position="1570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1614"/>
            <end position="1634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1661"/>
            <end position="1739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1762"/>
            <end position="1790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2285"/>
            <end position="2304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="2381"/>
            <end position="2432"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1230"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1871"/>
            <end position="1898"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1976"/>
            <end position="2095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="11"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1113"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1672"/>
            <end position="1686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1711"/>
            <end position="1720"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="255"/>
            <end position="262"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00064372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI08816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="16">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2432" mass="277471" checksum="9145BECD5FDB208C" modified="2018-11-07" version="1">MSSNAGGGSSPRRNNPFSRAASPSTTPTPHGRSNSTILSTPASHGRSQSSSSIGNVFGGAPRNYRSDSRSGTPTSSSTFAPPFIKTEEDVRRQSQGAVEGIEGENDFSGRRYVWLKDPQQAFIRGWVIEELPDNRLQVQTDDGTQRQVDAESVDKVNPAKFDKANDMAELTHLNEASVVHNLHMRYQADLIYTYSGLFLVAVNPYCPLPIYNNEYIKMYKGRSREDTKPHIFAVADEAFRNLVEEGRNQSILVTGESGAGKTENTKKVIHYLAAVAQSETANRRQSQPSTLSQQILRANPILESFGNAQTLRNNNSSRFGKFIRIEFSRNGVITGAFIDWYLLEKSRVVRINAHERNYHVFYQILKGADHQIKSDLLLDGLGVEDFAYTRNGHDSIVGVSDTDEWDLLMEAFDIMGLSGDERLSIFRTVSAVLHLGNIDVVKESRAADQARLAPEGKEQAARVCKLLGVSLDSFLQSLLHPKVKAGREWVEKVQTPDQVRLSLDALSKGIYERSFGDLVARINRQLDRSGMGLDDSYFIGVLDIAGFEIFEENSFEQLCINYTNEKLQQFFNHHMFVLEQEEYAREQIEWQFIDFGCDLQPTIDLIELSNPIGVFSCLDEDCVMPKATDASFTEKLNSLWDKKSTKYRPSRLGHGFILTHYAAEVEYSTEGWLEKNKDPMNDNITRLLASSTDKHIATLFADCADADEEVNGGRSRVKKGLFRTVAQRHKEQLHSLMTQLHSTHPHFVRCILPNHKKRPKQFNNLLVLDQLRCNGVLEGIRIARTGFPNRLPFTEFRQRYEVLCSNMPKGYLEGQAAAILMLEKLSLDKALYRVGLSKVFFRAGVLAELEEKRDALITEIMARFQSVARGFIQRRSAYKKLFRTEATHIIQRNFHVYLDLVENPWWQLIVKMKPLLGATRTATEVKRRDAMIKQLNDKMRLETETRQKLEDERRNCQSEMMRIQQTLESERALALDKEEIFKRLQNREAELEEKLAGAIEDQERLEDQLDDLMEAKNRAERDVEKIRSQLEQAAALITKLEEEKKQLYAKSISLEQAVEDISQKQSERSEQEAALEDEMKLLQSQLALREKKTQDLESKLLQADQDFEVRLRAAQKESESTKKRSAQLSQENDKIQQQLTQLSKTSTDWEDLVRSKESELALLRSDKRKFDNERRSLEDQKKALMDEKEKISAKFRDVQAELAATKSKQSQLGREADEAKKLLEARLSEDAQADENRSLLESQINDLKEELYKTQKDLSRERQSRDDVLLLGEHKYQSLKDEFDTLNESKIIIEKELYAQQDTLRRTIEARTSVEKERDEARDEIRRLRVAKTQAEEARLEAEVAGERQASKAAREREESLRKDLEAAQQRLQWFEDECGKLNRQIEDLNKLILSSGEFGLKNDQAKERMERELSTDECGKLNRQIEDLNKLILSSGEFGLKNDQAKERMERELSTVKSRLAASENDNRALLNKLQQKGLEIARSTSRAVDASRTQLLSLQREKTRLEEQNIKLNKQLGDSQVTIASLEKKAEKLQLSLEDLNHEVAREVKTSRNAEKASSNSSVQLAEANRTIESERQLRTQAQATVRSLQASLDSREKELEELRGQMLSALKTADPEMEMPATSSSSDVSGDKSLLKNFDLVRKVEALQQSLRAQTAARTNAENQLAEMRSARNDTPSRAKLEELSLNEAPYSPSPTQRKGARMESRRSSNTSTPTRRLVPDYELQGSTRSDKTVDTVSLKKRMDLKSEVEELQNQLQLAQMQNRHLQSQLERGSPAPDSYDEQSPSVRRMQKLEKVNSRLHDMLDDSAKKVSTLEKNIRTGELSLRDVQARSHEEILDVLNSQEESRRSLLHSHKDAVAELTDVKSHFDKMRHERAKLEVELRDTKSDLQEMTVAREQESQSRSQLLQEYTDVQIRLDAESSKLADVMSSLEVYKARADEYFGKLEQAEITVLKASRAEQFAKSQAKEADDTYAEVMAERQKMESSMDDLQRQNQRLEERVEDLSTDLESITQAKKRLQHELEDYRNQRAIDIEDKESSMEQTRKKYQAEFATLTKELDLAREEKLYKQAEIARLREELDELRSKWDDEVLNSSTWAKEKARLESTLADVASSREEAVNAHNEAQGKVVSLLSQVRTLRSSVDEMTSERDLLLREKRSVEACLAEAKAGLEGLTKGESPSLRDAAAMDRELLELRSNLAHQEDVAAAAVERMRRAEALVSEIQKDIAAERESGTDLQRQKASLEKSLNEAQLKLVDLETKGYSSASQDIKFLHKRIQELESQLESKESERSKSQRSARNVDRVVKDLQSQIERKEKQNTQLSEDIGRMRDKVDKLLKTIDDLQASESTNQLSARRAERELREEKEKATRLERELLGWKGLKGHNASSTSAAGSLRGRIAPPSWAESDDGPASVADGRSRRRPSLTKGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L350</accession>
    <name>A0A367L350_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_4821</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000018">
        <property type="protein sequence ID" value="RCI08828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L350"/>
    <dbReference type="OrthoDB" id="5986190at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="161"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="365"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI08828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="901" mass="101461" checksum="9AE495D3BFFC0985" modified="2018-11-07" version="1">MAPDDYGQTCEDLYRQICQKLEGGPKEHLRFAPRGTSSTVLQDDQLRRFMRSLNLNDPPLTEAQFADRVNERELHDFLATLILGCCSAKAAQAFVTKLAAAPDFDEAIGRLPASEDQLEELFGKTVDVLKFHGNQAYFCTVVLRKGDEVCVEDDGFQRLPYLENHSLRKGSFGEVFKVVIAPGHFHNAHSDDGFYFNTGPLELARKDYILDKEALAKSEFQAMKIMQRGRCDNIVECWGCLRIESTYSLFMPLAICDLSDYIKVTHKAKPQTREAKADIIRCAAGLAAGLHFLHEELMTPELEQLVCYHMDLKPNNVLVYQDKENLQKKVWKLSDFGLSRVKIRPNIDRNFDSLFVQRDQVRDPSASATLNKRGEGTYLAPESKSDGRSMRASSDVWSLGCIMSIIFTYLEEGSEGVDRYSTQRAEYPNADDLDRFFLPRTTWAKSKVHPLVKSWHTELIDKATKRDPKEGQAVAFVLRNLESKVLKLDCKSRWPSSKVNKMLVEAYQKYRGLGGEGSASADHKPPSRASMLRRVESSPGAGVCVRQVAPSDDFKGSVISPDAALVVYWTDTKIVLYMSKSLEQMSGPLMPSDEFILPKLGCLWKSVCLSKKRLIACTTGSNDWYLFDFYGPTAVEGKLKPPEQKVLQVPEVHRLAISPDGSKLVCVAQNEEGGRKLGSLFYAAVSDLFRAGKDREPEANRGWKRMGLEWPAADVVHLSVSDANDVHLVVRPQRTTGKREHKIPMMHVSLRKLTADTLSIKSVGYDGSRTGSFFTTFCPFRHGATCAVVTHDKRLHIQKFDQSDGKGDVEKVIPKYRVRRLLIGDDNRIYALGTTEVSSRMLLLELKVQHLEEELAVLEMGNLPGLTNDEDFSEMLCDEEEYDKYILVAALTRTIYKVAIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3N1</accession>
    <name>A0A367L3N1_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI09017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3N1"/>
    <dbReference type="OrthoDB" id="4922812at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="326" mass="36016" checksum="47C8D9C6E7C64279" modified="2018-11-07" version="1">MDPTVGIDSIANLSSRLWNRSVVELIGYCILYSSVFGFHTRRTVATYNGKFRKSTSYALPVHIATGLFEIFRYQIRAALYGEDFVTAKGGDVIVCFIWAWTSLALVRSLQRGDPSTTRPAYQAGTLLRPVAAVAAYAMQSPALYRVCAKAINSFIYARVGIFIMHKSGFLRRHQDSAVYAVCIPVSAILSIHEGRVAGAVPLYLAAMFAVGWLNHWVSAAIKDRPAGAQKKTIKDRFVDAMLSLGFAELDDLKKFFQKKRRPTSLCPDIMDEYIRQQAAAFNPSRLSSIDSNFTGEMQPSSWDALTGTSPKSSWEALTGEGGEEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L3R4</accession>
    <name>A0A367L3R4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidase M50B-like-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000017">
        <property type="protein sequence ID" value="RCI09057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L3R4"/>
    <dbReference type="STRING" id="1330021.A0A367L3R4"/>
    <dbReference type="OrthoDB" id="40823at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049500">
        <property type="entry name" value="Peptidase_M50B-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33979">
        <property type="entry name" value="OS02G0221600 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33979:SF2">
        <property type="entry name" value="PEPTIDASE M50B-LIKE-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13398">
        <property type="entry name" value="Peptidase_M50B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="30544" checksum="EC516228F730E2BD" modified="2018-11-07" version="1">MAPQLVVPDVSIDEIAPFLSSLDKNASQTTHHLSPRDMQHPTPSQQLTLGIIAVYVFGIAVLWNVPYLRMVLWPFKMLVIAFHEFGHAITAILTGGRVDSITLDPREGGVTQLRGGISFITLPAGYLGSSIIGALLIFCGFNVVASKIASIALGLCFLLTLWWGKRDWLTIVTVLMAVGLLVGCWFINHAEPLRYVVLFIGVMSSLYSVWDICDDLILRKVNSSDASVFAKRYGGSSICWGFIWAFVSVLIMAGGVVAGLATFSQSAEQQQMESKAFMPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L432</accession>
    <name>A0A367L432_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_1488</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L432"/>
    <dbReference type="STRING" id="1330021.A0A367L432"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF23">
        <property type="entry name" value="PENTACOTRIPEPTIDE-REPEAT REGION OF PRORP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="614"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="872"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="876"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="897"/>
            <end position="917"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI09177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="965" mass="109894" checksum="6A63195DBB77B559" modified="2018-11-07" version="1">MSSSSSSSSSSSSSSSGPRFSINHRSTNQRCAADDQSLTNRITMVEVVVFFTGLISYPDSAASTTTIATATTAIITIITIITIITTPVHNNNNNNNKRKQQRRKVENSRIRNAFTVDTPAIQAAVQRNLLKWPYIPSPRRYPTRRGSSVGHWRRVKAARVQVGFNVVALRGLGFRAPNWRKTLRLLENLTPARAEMPLMSALRIVLPEAVDLNLPSPPGKIEVLDSTTLLINRVIAVVESRNHAATVVEKHNRTTVVIRGRRDILAQAADDLIAACKDVRIYHLGHVSATDYETRCLWPVPDDDGETRPSSSIWPRSTDDDRIWVHREAPETIWIDTRYEDIPKPKSWTADGDSSFESYITTLVRSRIPSHLVTSLYRDPTTKKPASKLIDAEAFKTRLILKAFKHPTSTPFVTPRALKTALSYMIYRGGHRSEANHLFRRAQAKGLPIDTDLFNIMMVGYVDKYDVASFHGLLRQMEKHYQHPDATTWLLFLKLLQRDEEQLLAMSSMFRYGFFDAPCIRRCVAAIRADRDAYEFLKDHGGGRRAAGGRNLYDFMNAQASRYGRDWLTTPALNNVLQEAFLFDRGRDDDVIDVDRLLDTTDDNNSPLKGFSLQTSTFNLLLDHYARQRNWVKVLKTLSQMHRHGCPPDDKTYRILVPLAIKSRAPFALGAIFFYAALGRNLRRSARKTFLHVFLGRHEDHPFWSVHPPRIFSKPMARAVRSNPVVHGDSAVAAAEWAVLRRCQGYKPDQPLHEALAACWRTMDIPLHRIYNGGPPPHRPLRYFSVRLRDPARIRPKMVVHLDAWFSYKDMVHEHARQKPSSSLLADVDDDPSTAWSWKDFNPKPLGPYLEQVVSGGRPSAEDVYRRMLQQEKDTTQTTTNQQPHRLSTTATDRAISSRRSRSRSRSRNRRPRRVHHFMVGTKLRLWRMRGSRPVFWTAEKQDEAIIRSLTAPSPPDPARTKTPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4B1</accession>
    <name>A0A367L4B1_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Vacuolar-sorting protein SNF7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Vacuolar protein-sorting-associated protein 32</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_1519</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4B1"/>
    <dbReference type="STRING" id="1330021.A0A367L4B1"/>
    <dbReference type="OrthoDB" id="5592979at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1060">
        <property type="entry name" value="ESAT-6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF10">
        <property type="entry name" value="GH13992P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="180"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI09264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="199" mass="22090" checksum="FF86EB76CFAA73A9" modified="2018-11-07" version="1">MWSWFSGAAAQRKDAPKDAILGLRSHLDMLQKREKHLQNQIDEQQAIARKNANTNKNAAKAALRRKKTHEHALEQTVAQIGTLEQQINSIESANINRETLAAMEKAGQAMKQIHGKLTPEKVDETMERLRDQNALSEEIVTAITGASITDPIDDVELDEELEELQQEQLDEAMIKTGTVPVSDAVHKMPTPAATNAEPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4G7</accession>
    <name>A0A367L4G7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">U3 small nucleolar RNA-associated protein 25</fullName>
            <shortName evidence="10">U3 snoRNA-associated protein 25</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_1430</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
            <location evidence="2 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the UTP25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000016">
        <property type="protein sequence ID" value="RCI09319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4G7"/>
    <dbReference type="STRING" id="1330021.A0A367L4G7"/>
    <dbReference type="OrthoDB" id="10264378at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002356">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010678">
        <property type="entry name" value="UTP25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053939">
        <property type="entry name" value="UTP25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053940">
        <property type="entry name" value="UTP25_NTPase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933">
        <property type="entry name" value="ORF PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06862">
        <property type="entry name" value="Utp25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22916">
        <property type="entry name" value="UTP25_NTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7 10" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="UTP25 NTP hydrolase-like" evidence="13">
        <location>
            <begin position="249"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="UTP25 C-terminal" evidence="12">
        <location>
            <begin position="518"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF06862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI09319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="709" mass="80737" checksum="416F76B853A58506" modified="2018-11-07" version="1">MNPRGRGGKPRGRGFRGRGRSRGSSRFGPSRQFHGGRLADKEVPEEPDVRNESEGAIDDEAESIASDEEEDTQLSHPYQALLRSFHDAAAPEAKRRKLDHDVPTEKTSDPLPPRDEEPSAEENDDVDRVGEEEDEEEGIDDHPYDVSDSENEDDSPDPFDVHFAHPDEASVQKAIEDVVQGRWATKRALIQPLRATLLSPGSEASFSAPHPASRIDSFRLKQKLKQIAAKQLGELDESQRVLAPLLFDYRDVLHCHRTVANSDGLRRLVCLHALNHLFKTRDRVLKNNSRLAKEGEDTELELRDQGFTRPKVLFLLPTRNSCARMMYAIQGLCEAEQLENRKRFEASYVDKSSSFRDDRPTDFVDLFGGNDDDMFRIGVKFTRKTIKYFSPFYGSDILLASPLGLRMAMGSEGDKKKPDSDFLSSIEMIIVDQADALLMQNWDHVEHIFEHLNRQPADAHGCDFSRLRSWYLDDQAKFYRQTVVLSAFNTPELSELLRQHCHNWAGKARLQPEYSGVMQQLGIKAKQTFSRFLPASVEQEPDARFEYFVSAVVPRLVRLAKYSSGTLLFIPSYLDFVRVRNYFANSTAVSSVTFGAISEYSEVPDASRACSHFASGRHRLLLYTERAHHFRRYRIRGVQGVVFYGLPDNPVFYREVAGEFLSRSQQELGVEATVRVMFSRFDAMKLERVVGSSRVAKMLQERGDTFDFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4L9</accession>
    <name>A0A367L4L9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Ubiquitin-conjugating enzyme E2 2</fullName>
            <ecNumber evidence="3">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">L249_3706</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="21">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="3"/>
    <dbReference type="EMBL" id="LKCN02000015">
        <property type="protein sequence ID" value="RCI09375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4L9"/>
    <dbReference type="STRING" id="1330021.A0A367L4L9"/>
    <dbReference type="OrthoDB" id="9984419at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23790">
        <property type="entry name" value="UBCc_UBE2A_2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000007">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0749">Sporulation</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 21" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="23">
        <location>
            <begin position="4"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="22">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="20">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="RCI09375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="151" mass="17271" checksum="DEAF6F476558A031" modified="2018-11-07" version="1">MSTAARRRLMRDFKRMQTDPPAGVSASPTPDNVMIWNAVIIGPTDTPFEDGTFRLIMQFEEQYPNRPPQVKFISQMFHPNVYATGELCLDILQNRWSPTYDVAAVLTSIQSLLNDPNTGSPANVEASNLYKDNQREYTKRVRETVENSWED</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L4V0</accession>
    <name>A0A367L4V0_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_3713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000015">
        <property type="protein sequence ID" value="RCI09441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L4V0"/>
    <dbReference type="OrthoDB" id="4911976at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016925807" evidence="1">
        <location>
            <begin position="24"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="347" mass="39605" checksum="589C357E3EAC8D9A" modified="2018-11-07" version="1">MIFSPATMRRQLVMLALAANVNGEMVNDARAIARNKTEALARMTVIDWNSPPSYTYTRIESSCDAYHLPFQCHQSAFTTSEKLTPNLIPMGKRPFTIQYDVVRQPDFLNINSDGAEMIMVETDWESKSDHFWIASASVTGLGTITVARRSQDEARPSIKAKIRSFGLKATCPGGHECHFETWIFHSAFEGPCRREAKIDKCVGSKPPMYLDNVCFYVNQHPDRYRDGFESEYDYSPDLAGLGQNVELPAHLKRPWPSQLRCSQYYKWAWKTCRDPQGPRFKDDAYCRFRIPVMRDGEPLSTSVFIKQNRRSKRELESTGGDVTVDVIWGFMGVDEKGNMIIRGADQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L5V9</accession>
    <name>A0A367L5V9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4178</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L5V9"/>
    <dbReference type="OrthoDB" id="5410040at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40020">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40020:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI09813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="123" mass="13904" checksum="F6D96B3DCD236447" modified="2018-11-07" version="1">MSIQTLFIRKASSNFVRCFIFINTNSNAPPSDQLRKNATTPAMPPHLHPRSRMTSSLFASTLVASFFVVALPHVLPCPVPRTKYADGEIMVDEQGRRKRWRKTEATRTDQGMVQFDQPAGEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L607</accession>
    <name>A0A367L607_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_3805</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000014">
        <property type="protein sequence ID" value="RCI09652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L607"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI09652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="89" mass="10389" checksum="7319A620BE07AE50" modified="2018-11-07" version="1" fragment="single">ENRSFSCKLLQKVIQAVDEKLTNREEAIEEELEAGEVFVLRRYFSRYFKVPTCSTLTYLYTCTCQSDRSDRSDPITPAMTAMTRPLWPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L663</accession>
    <name>A0A367L663_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA/RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">L249_8481</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI09909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L663"/>
    <dbReference type="STRING" id="1330021.A0A367L663"/>
    <dbReference type="OrthoDB" id="69928at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018834">
        <property type="entry name" value="DNA/RNA-bd_Est1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019458">
        <property type="entry name" value="Est1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045153">
        <property type="entry name" value="Est1/Ebs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696:SF36">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696">
        <property type="entry name" value="SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10374">
        <property type="entry name" value="EST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10373">
        <property type="entry name" value="EST1_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Telomerase activating protein Est1-like N-terminal" evidence="3">
        <location>
            <begin position="72"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="domain" description="DNA/RNA-binding" evidence="2">
        <location>
            <begin position="197"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="547"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="607"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="798"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="634"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="686"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="711"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="741"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="807"/>
            <end position="816"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RCI09909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="832" mass="91869" checksum="375A074E7F426391" modified="2018-11-07" version="1">MASTLTQASQQWHNALKLRKALLKQLDGRRVDHAHSLDTTWFEAFDGLLQRYRLACVQTIFLDFQYAAKENTEDALWELHTSINHEYRQIVRRLRSNSHPVERRKAEKMYNNFLRIALKFYKGYIQRLSARYDIQELKRVVMGIEVEQIDAEDTISPVPGSLSSLVLESCHSTLLHLGDLCRYRSQAKNKSSSVDFALTYFSLARHLMPHSGFAFHQMGILNAAQGNHLDAVYHFYRAWAVEVPHPNVKANLEAKFNSLRAPNAIRPRVNPSAPAEAFSIWFVKLHAYFYAGEAFSQQRELEEEVMHRMEMACRDGRSGDTLLKMALVNMSAHAIASSASTEKGMMTNSNFWKFTLKFNALFISTLCRVIHLELEKVGATNSPDKPIEIPAVVASLLPVLRVYCVWFVAHRSELVAAYDAFGAALPMMMKGIVNVFTSFFAVACTHDELPSCSYLLPEDLELRGHQLLAGDDIPSQCRVDCKDDSVKPYLSDPQQCLPGAQENLARTFDVLRCAYFLHSDEMTPISIRNGEKRRVFFEYQPDMAPVVSESGGAKAPEVFSNQSPAMTPHEPSEQRQQDTSAEVEMAMATSADDDDDDAEKRVMSMLTPFLKPPTPSPQNHVRSPSDAAPGVESTPANGSGALNQNHWSPAATGRLSGPITPLPWAWDNTPKPDSEQAAGREAFTRGSRNNSPRDSMTGSIDDPFATPGRNDGARAHAPTDRRASKTASEEAHRQHMLQTLLGDNSARTSSPAQPRGSRAGASSMIGTQRSLLAADSTGFSHPSSLYMGTPAYGIGLGVTGLRGLGLQSPTQGSGSSARRVGIGDSLGHESAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L706</accession>
    <name>A0A367L706_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HIT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_8687</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000013">
        <property type="protein sequence ID" value="RCI10204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L706"/>
    <dbReference type="STRING" id="1330021.A0A367L706"/>
    <dbReference type="OrthoDB" id="1915375at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648:SF2">
        <property type="entry name" value="HIT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46648">
        <property type="entry name" value="HIT FAMILY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="4">
        <location>
            <begin position="26"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="2 3">
        <location>
            <begin position="118"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="1">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI10204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="187" mass="20247" checksum="956804FEE4D98938" modified="2018-11-07" version="1">MSADPTCPFCAIAAVYAPWDALQPPPTVSTTLTSPASYVVLSTTALVAFLDIMPLSRGHLLVCPRVHRPKLTDASPSEARELGAYVRVLSAALARATGVADWNVVQNNGAAAAQVVPHMHFHLIPRPEIRASGRVCESFTMFGKGMREELDDDDAEVLAAALRRHVSDVLAEERPLLLRREKAEAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7Y3</accession>
    <name>A0A367L7Y3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">OPT family small oligopeptide transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_4318</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7Y3"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="409"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="473"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="510"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="540"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="699"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="726"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="756"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="810"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="875"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="905"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="927"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="955"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="202"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="36"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="152"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="203"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="329"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI10521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1019" mass="112889" checksum="09BC99A396DFE436" modified="2018-11-07" version="1">MPRSVPSYPGAVPLQTLTLPDGNVSGDCSPRSNQAPPLRRPLQSSSPPSASLPSPLSESSSSSYHSHSHSPSTNTPSAQPVILNTRSPPSRHDGDSQPAMPLPRKTPSFLLADGNGRNAYAYGSVNSARRNSSRTEREAEDGQDFQPLRNSFRSRRSMSSRRSHLSRQSSSRLSEDLDGAALTSGLEGRFGLVEAPLLGEILDHDDDDDDDDDDDVCESDDVDDDDSFSSHSDESRFDSPPEAVRASVPPTDDTTLSINTPRMWCLSVLFSILGSSTNLFFSLRYPSVAITPVIALLLVHPLGHLWDLILKRPYDAQDEFVDGVRVASSSSSSSSSSSSPAVLNGDSAAAVTPRPKKKLNSWRLWLAQGRWNEKEHTCVYVSSNVAFGFAFATDVIVEQTRFYKQEAPIVYQLLLTVSTQILGYGFAGMARRLLVRPSGMIWPGTLMSAAMFSTLHRQDNKPANGWTMSRWNFFYIVWGASFAFYFLPGLLFPALSYFNVLTWFAPDNVIVANLFGVSSGLGLFPVTFDWAQITYVGSPLLVPFWAAMNVIGGLVIVMWITAPVLYYSNVLYSSYMPMLSSAVFDNTGSVYNVTKILTPDFLFDRQAYARYSRVFLPITYVLSYGVQFAGLAALLTHTLCWHGHDIWRTIRRSLAEARRDANPAYRPVESSTSLPGEDGLLSREDVHCRLMNRYRDAPLSWYLLTFVSMAAIGMFVVEYYPVHLPWYGLLLALAIGAIFFIPNGIIMAITNQHSSIYLICQLICGVVFPGRPIANMVFVTYGYISSAQGIKFAADLKLGHYMKIPPRIMFLVQVVATLVSSVTQIGVLNWMFANVAGLCTTEAVNGFTCPIARVHFNGSILWGVVGPAEFFGGKAIYRALVWCFPLGALLPLPLWLYARRRRTSLVRKVNLPVLLGSMSWIPPATGLNFSVWALVCFIFNFLLRRRANAWWAKYTMTLSAALDSGLAFGILVVFFAFVYPGWMTGFHWWGTDVYKQGCDWKACSFKTVADGETFGPHTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L7Z9</accession>
    <name>A0A367L7Z9_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_4484</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L7Z9"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI10546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="126" mass="14092" checksum="7265AEB6BB1D35D4" modified="2018-11-07" version="1" fragment="single">HNNVGGGYGYGYSTATLYSGYGCTGPGPTTYRDDRNRVRIRVRIRIRIRIRNKIDSGIRRLRPYGPYGPYEGRNVGYGYGYGYSKRPRCYGTRPEGLGGLRNAGPAIAGPRPPYVIEAIRYSSYTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L898</accession>
    <name>A0A367L898_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_4445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000012">
        <property type="protein sequence ID" value="RCI10647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L898"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI10647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="122" mass="13681" checksum="5A529941E618B406" modified="2018-11-07" version="1">MVEQVTCLSVLSSIFALPTGHRSPAWVQDQEKTMKKEAMEKGKKRPPDSRLRPDFPSFPLLPREAKASVLGIIPRAIILYRSLLYIPFMSNRLAYSPCSYSAPAWSSLCVTRHIASPNAYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8E6</accession>
    <name>A0A367L8E6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5381</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8E6"/>
    <dbReference type="STRING" id="1330021.A0A367L8E6"/>
    <dbReference type="OrthoDB" id="4930473at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI10695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="130" mass="15179" checksum="FACD2A3E1A45C3D8" modified="2018-11-07" version="1" fragment="single">TRCKDIRTFSRKKGEFSAFLTNLKDKIRTDKATFRDEEDRIGFLFRSLEGKARKTLETYLLTKTKDDSLSYEDFYGYVKDSVYYRKRDAAIKRLDTKLVLPNNLPALAKYSLSILLPKTPLLNRQIDLAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367L8H5</accession>
    <name>A0A367L8H5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase S8/S53 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_5172</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000011">
        <property type="protein sequence ID" value="RCI10730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367L8H5"/>
    <dbReference type="STRING" id="1330021.A0A367L8H5"/>
    <dbReference type="OrthoDB" id="19448at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF58">
        <property type="entry name" value="ALKALINE PROTEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016902392" description="Peptidase S8/S53 domain-containing protein" evidence="6">
        <location>
            <begin position="16"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="7">
        <location>
            <begin position="159"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="197"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI10730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="792" mass="87294" checksum="49EE611A40CDF252" modified="2018-11-07" version="1">MRFTFLFGVFPLSLALNPSSVDDELAPRAGSAKPAPLHKAVKGDDVLPGKYIVKLKRDTNSSHLEAILSRFSGETDHVYGGRFHGFSRSLSEQELDAMLNHEHVGVHRVEYVAEDSMAVTSSLVQNFDSTWGLSNISHYDEWLGPEGYTYIYDDSGGQGTCTYVIDSGIESQHPGFGGRAEQIKSFVPGQTRDDTGHGTHVAGIIGSYQFGVAKQTKLYGVKVFDKKNTAPVSRVIEAVEFVTRDMAKRDCPKGVFVNLAFEVSLSQALNDAVSNLINMGTFVGVSTGNSHLPADKVSPASEPAVCVVGAIDEAHRPLGYSPHGPDGKPLVSEYGPRVDVFAPGENIRSLGLGGSEGQMSGSSQATGFVVGIAAYLATLEAVTGTKLLCERIKSLAVIGAIGNLPKGTPGRFAFNGAHMETKMVSDVSMEIRGHNVFMCNNDDFKPPCKYVDAPAGTCVDMYAADMVRVSSLRPSRNAGTCRFYRQFKCTGRDSFETNYDFGGEKLDQPADKSLELPSEPLHWVRVTLGSGITEGTYDNLELNFAGQGGPNHVVARSPDSGFNDREEVDLKTVFKHDKISLRRIRHIQLTATKTKWAGGDEWFLQGIHFRAFCGGQMQRWVENRKFATIGRKVSQGRSGRGIGHIHVAWQGFTGPEDWAPEVPCSHFSNLWVYIQIAYWPRAGTDDKVGVEFMHKKFDLSRNVQSGTLIKKKIDVREVFPYQGILHWGSINYLKVYNEGGSDDVKIDRQCSGIQTFAEFRWDINNWIAGNDLRQTELDISKWYTIRDKHFTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LA22</accession>
    <name>A0A367LA22_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_7226</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LA22"/>
    <dbReference type="OrthoDB" id="2020972at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044574">
        <property type="entry name" value="ARIP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056026">
        <property type="entry name" value="DUF7607"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797:SF1">
        <property type="entry name" value="HELICASE ARIP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797">
        <property type="entry name" value="RAD54-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24580">
        <property type="entry name" value="DUF7607"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="855"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="1200"/>
            <end position="1362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="435"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="557"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="728"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1478"/>
            <end position="1511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="442"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="494"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="557"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="739"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="773"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI11269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1668" mass="188117" checksum="12FC77359A6F4ACC" modified="2018-11-07" version="1">MDEDCHDDPFLWDVDAVARHLCSLKRPCAKEPVALAAKVAEQGLDGHTLLSFEFVCSRVELFDCLGVTVGSHKASLQRAILSLRSASSAFRRWKIDFLREQSDESPPPEPALIPSNGISNAAANGQQYLEATKKHKLDASEAPSGVSLTSSVVGQDITPAPPTDNAALHFAAEAERPLKRKRVAPVQLTDGFANRAEDSPAWEYQSQHAYLGRGAISITDITAPDRLHTTRLVETAKTFATPFPFKVPPGLRSTIGRIMKLHLRATGHREALLRQGLISRLPSPSQESDEILNLSDLPDSFDEETLREIDLEEAETKMAQSLSRAIEPERVLALLQEVDTKIRTAWRENKLPRYQRKAYKLWTDATKRGTKTKQINQARVTAKTIGHRLQALKAEIAQQPYAKESEVREQARSFEQSLEDRLYNEWLAGVLESRAEPPKPKSLPRPKRRAAPKSRFPDGDEILTSSDEDDFIVPDDDDQSVQADDLDAPVEPLNESRLRSSDSKDDLAESSARSKKNEASDFELRTPIKAEYFLDLTQAETPESLRRQSWRGTSVIDLTTPTKPKSRLAQPSVSANDEDDLFVRDEEDANDESLADVEQIGKARPQHWAKEKNGPKLVICLLWRLPHFRRSRVLEAARRQDDDDLYEVTVTKQLSEPLENPTLLDKAGPETTAFDLTRIFLSFVKLKNCKEPRIMSMSAADRKRLESGKEERWGEFLKLLRENAHRFPEDSQIYRPDTLDDGIDDLEEGQDDELPESQESPSQSRKNMPKEIVQNKEAVDLRQREQRRLQEQEARRLKLRAELDLSGSMSQDKSRLIINESKTEDQPFIYVNERVGMRIKHHQIEGVRFMWNQIVTDAHTSQGCLLAHSMGLGKTMQVITLLLAIQESVKSSDPDVRSQIPEHLWSSKTLVLCPAGLVDNWMDELLLWAPDQILGPMRKVESRQSLEDRRSTVLSWADHGGILVTGYPMLQKLMAGDGEIETKLTQRPNIVVADEAHTIKNPESKAHQACSRFTTKCRIALTGSPLANNIEEYYYMIDWVAPNFLGPLKEFQQIYAKPIQQGTYQDSSRWEKRTGLRQLKVLEITVAPKVNRRTTKTCAKDDLPPKQEFVLCVPPTAMQRRLYDLYLTSLQNPCEGEMRSLDDRIFAILSNLALVVNHPSCLRKKAEMVRDKKVHAQAQEGNVLPDSLVSSILKETKVPDLSNSLMSVKTELLLIILDKARELGDKVLVFSQSLLTLNYLETVLKWQKRQVYRLDGQTPIGERQELVKRFNSGNQEVYLISTNAGGVGLNIQGANRVVIFDFKWNPVQEQQAVGRAYRIGQVKPVVVYRFVTAGTFEEDLQNRAVFKTQLASRVVDKKNPLSWSKKDAKILHRILDVPAKSLDEFVGKDSILDALILHKSNGEAIRWIMSTDTFEEEDPEEGLTAQEQRHAEDMAKMNHLRLSNPDEFERLKRETELREVERYKTGGIFVEQGTIDRSSSSAVNGAGASGATTTTGPAAETTAAGPQAAGPLPMTGINTYFGGMEREETRWNLVDSRPRPRASLFTAPLKSKAQDNFEVALRQSMEKSGYEQQEQQKATKVTLAIKQVRKEKGEGFLPDDQHWRLLTGFLQSPRFALSVASGHLSPSYLARTSKTELERRVTVLNTLSETEFDKQMKASPDKAPDPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LA25</accession>
    <name>A0A367LA25_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_7507</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LA25"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI11263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="70" mass="8008" checksum="A26C18C0A3CFEFEB" modified="2018-11-07" version="1" fragment="single">RRDKKNKWEKKKTSRTKADRAHKRSAAEVGGRRWPSVTGIIIIIIIIIIIICGRVGTSVHMRTDAVHTYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAP5</accession>
    <name>A0A367LAP5_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Protoporphyrinogen oxidase</fullName>
            <ecNumber evidence="4 11">1.3.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_7297</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 11">Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>protoporphyrinogen IX + 3 O2 = protoporphyrin IX + 3 H2O2</text>
            <dbReference type="Rhea" id="RHEA:25576"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:57307"/>
            <dbReference type="EC" id="1.3.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="11">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; protoporphyrin-IX from protoporphyrinogen-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.3.4" evidence="4 11"/>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAP5"/>
    <dbReference type="STRING" id="1330021.A0A367LAP5"/>
    <dbReference type="OrthoDB" id="438553at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00324"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004729">
        <property type="term" value="F:oxygen-dependent protoporphyrinogen oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004572">
        <property type="entry name" value="Protoporphyrinogen_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00562">
        <property type="entry name" value="proto_IX_ox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF3">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0274">FAD</keyword>
    <keyword evidence="5 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 11" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 11" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="13">
        <location>
            <begin position="71"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="352"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="370"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI11489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="630" mass="67799" checksum="2975AA82979EBD38" modified="2018-11-07" version="1">MPSEVGDPPTTTNEALDSMGGLRRATDGRPRRLGCLWKETSVGGRSGGWRWTTTAAGGDKGRRIAVIGGGLTGLTTAYRLAKQQPRSTKITLYEASSRLGGWIQTDYAEVDVGGVRGRISLERGARTMSSLHTSTWRFDDLALYDLANDLGLEIVSPQDAPRFILHADQKLEALPTTAWQMVRSRTVRKCLWAGPGYALRRLLTARGSGSVPSEDVSVAEWIRKVTMSRAVVDTASALMHGVYGGDVEQLSARTVLGAMYWRYHLPSPPSGHVLMPKAESVFLRQLSADAAVRSLALGCKGALLHFGTLGMEGLVRALEEALRERVNVVVRTGCSVEGIRYNAESSTVTVRTASSSSSSSSPPSSPPTPSSSSPSPSSSTYDKVIATVPPSTLSRLTSPSLPSLLPFESVSVMTVTLWYPRRQPHKPARGFGYLIPRGVPNPELALGVFFDSDVSVVGPGEPCSSHPPHQEQQGTTTTKLFVLLGGHHYNRGRLDDDDGPPSETRAVQQAKSVVHRHLAIPLDEPCFAQARFATDCIPQPLTGHEARLARADDELRSLFQGSLVVAGGFYSRVGALAAIRAGYDTAARLASDDDDDDRLYTGIETGLECVEVAERDITVRNLASQRGGDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LAP9</accession>
    <name>A0A367LAP9_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_7270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LAP9"/>
    <dbReference type="STRING" id="1330021.A0A367LAP9"/>
    <dbReference type="OrthoDB" id="8059989at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45818">
        <property type="entry name" value="PROTEIN VAV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45818:SF3">
        <property type="entry name" value="PROTEIN VAV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="2">
        <location>
            <begin position="200"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="740"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="754"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="833"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI11507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="875" mass="96516" checksum="4816A7D6FB1DDB4E" modified="2018-11-07" version="1">MSVGSPSPFPDSSGTEDESTEERDVVVQLHSHSSQDEKPHIQGIETLETSPSIENIGDTLRYAAPLPLASVEECSQEPQDQEPRLTRPFHRWVRSFHRKAKRRPSLWTADGAVLSPPPSRMSSSSGSSFRFVSAVRSASVSLASVSIVTRSRRNTALSRCVSRTERSSRASASGPRASEDSAVFDKTDVIDVAAVERSMQRRRILEELISTEEGYIGDVRFLMNVYVTILASLPAMCMGLRSSINKNLADIVELHEEILGELHRAVPHSEYTQPQGSYNVASLAIAETPGHRRWASVDGALERRRRVSWLQKTPGMLADPQVVAEVSKIFAKKMNRFFIYKEYGAKYELMIKDVASANQAMPQWETYQKGLETLASVLGSAKNSQDQSKKALKMADLLVKPIQRICRYPLLFAELLKYTPVSDCPNSHMEVDSVLTRLREANAEINRATDDSTIKATLERTWLLQDRLMFPNRKLDAASKIRLRSFGHIRLCGTLHVCWQSLNGGVEGQYLICLLYRDVLCLASAVKADPLYMVQACINLNGVSVEDVDNGRGLQCHTAPFSWKLVFECDHQLYEMIMTACTPKEETEWRTRLTRTANDNAEPCIFSSLYLDMKSLGTVFSKPGTVARRISIHRATTVGPKSALCQVVLKNTSVVRDAGSSASAALTINRSQSVLMTQSRMTVLAPSRSERARLEALLADVWTRETLPFPGITTRARSEHLVRTSASTVMRKLSVTSIASSFARRSSSLTQKAKPCEEPSGKGEVKRRGPKTSTDEVSGVEKPAEADPHRSPKRPRTGGGQGKAKEGRKARALRTSSANGQRLAPAGKTGSQEGHKSGDDETQRKGKTVNGKTVNGKAVNGKADEGGFGLKSYFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LB15</accession>
    <name>A0A367LB15_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Subtilisin-like protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">L249_7756</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6 7">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LB15"/>
    <dbReference type="STRING" id="1330021.A0A367LB15"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000014">
        <property type="entry name" value="Proteinase K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.80">
        <property type="entry name" value="Peptidase S8 propeptide/proteinase inhibitor I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010259">
        <property type="entry name" value="S8pro/Inhibitor_I9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037045">
        <property type="entry name" value="S8pro/Inhibitor_I9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF58">
        <property type="entry name" value="ALKALINE PROTEASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05922">
        <property type="entry name" value="Inhibitor_I9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016613455" evidence="8">
        <location>
            <begin position="17"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="domain" description="Inhibitor I9" evidence="10">
        <location>
            <begin position="40"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="9">
        <location>
            <begin position="142"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RCI11606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="386" mass="39525" checksum="090C2C035E4EF8B8" modified="2018-11-07" version="1">MLSAGLLLLFLPLVLSAPAQRSELAPLLVPRNGPPVEGMFIVRMKKSAAKGASVASAVSSIASDAHFTYSHAFSGFAASLKPDEVEKLRANPDVDYIEQDAVVTIFETQNDADWGLARLSNKKPNATTYNYDDTAGEGTCAYVIDTGIDAKNSEFEGRAKFVANYADKEDGDGHGHGTHVAGTIGSKTYGVAKKTTLLGVKVLDANGSGRNSAVIAGMDFVAKDAAKQKCPKGIVVNMSLGGSFSKAVNSAAANIVKAGLFLAVAAGNDGADASGYSPASEPSACTVGATTRVDALASYSNIGSIVDVLAPGSNITSTWVGGKTKSISGTSMASPHVAGIGAYFLGAGEKVDGLCQHIAKQALEGAVSGVPGDTKNLLINNGYRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LB17</accession>
    <name>A0A367LB17_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CBS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">L249_7579</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LB17"/>
    <dbReference type="STRING" id="1330021.A0A367LB17"/>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17781">
        <property type="entry name" value="CBS_pair_MUG70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17782">
        <property type="entry name" value="CBS_pair_MUG70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06409">
        <property type="entry name" value="PB1_MUG70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00291_B">
        <property type="entry name" value="Ribosomal_uS2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051462">
        <property type="entry name" value="CBS_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000270">
        <property type="entry name" value="PB1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005706">
        <property type="entry name" value="Ribosomal_uS2_bac/mit/plastid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_uS2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48108">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN CBSX2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48108:SF26">
        <property type="entry name" value="CBS DOMAIN-CONTAINING PROTEIN DDB_G0289609"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00564">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00666">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0129">CBS domain</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="CBS" evidence="8">
        <location>
            <begin position="94"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="8">
        <location>
            <begin position="161"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="8">
        <location>
            <begin position="264"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="8">
        <location>
            <begin position="330"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="411"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="599"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1098"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1026"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="72"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="416"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="615"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="635"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1111"/>
            <end position="1146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RCI11620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1146" mass="123980" checksum="9C179332162CD50B" modified="2018-11-07" version="1">MSGNTMRSTPNRTQGRGAIPFGNSPAGGASGIPRPVFESQPSETTSSVSASRQKQSKRDEAIRRKMESDLSKKKHLTNRARHTRKAPPGTVLALKPSPALQIKPATTVSEAAQLMAAKREDCVLVTDDDDRIAGIFTAKDLAFRVVGAGHKAANITIAEIMTKNPLCARTDTSATDALDLMVRKGFRHLPVMDENQDISGVLDITKCFYDAMEKLERAYASSRKLYDALEGVQSELGATQPQQIIQYVEALRSKMSGPTLESVLNGIPPTTVSVRTSVKEAAAMMKEHHTTAVLVQDQGAITGIFTSKDVVLRVIAPGLDPANCSVVRVMTPHPDFAPMDMTIQAALRKMHDGHYLNLPVMNDGGEIVGMVDVLKLTYATLEQINTMSSGDSEGPAWNKFWLSIDNETESMVSGEGSHSQRPTNLSSRLMSPEAARERVGNDSVLPGDSASHVGADSPCRSLIPETPEPANPADAPFPFKFKAPSGRVHRLQVTASHGLDALVSSVAAKLRHEVDAIGGVPVVEEGKMSDTGFALSYMDDEGDTVSITTDHDLVEAIVLARQRLREKVDLFVHDPEEPPVAAAAAAAAVETTPVIPTPLASSASLARERRRTLEDDYDDDDDEGADADADEKGSAIRRARRTRPARAQEQLVAGVPNDLLLPGAIVTLAAVIVGVFAANSDTNGSSEGSELKPAALAGNRRIGQAPKPSQTRKNNRQMAAQQAFVSLAAGELRSHQGLPWTRSRKVGDMIVTPAQQYAEFQRIRWQSRGLGSELKKRFVPSDLINDPPAAEDVTLELLMASQTHMGHHTSLWNPANSRYIHGVREGIHIISLETTAAHLRRAARVVEEVLYGGGLVLFAGTRLGHMEIVVKAAEMAGACYLFTKWTPGSITNRDVILKTHPVKVVDHNDKEIHGFRDFVASARPLMPSLVVCLNPLENYTLLYECSLKNIPTIGVIDTDADPSWVTYTIPSNDDSLRAMAVIGGVLGRAGQRGTERRLYEAAKGQITWTTPPELTRHMNAEVNEAKKKQKEVMKMMQDDLEEFNAEELRLLQQKREAEARGQVDEKAVFGLLGGKADEREASAVAAALVVDGGLPMATAVVDEGPPNATTEDEKRKASTDDDGPSKKATVEDEGREGVVDKAHEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LB98</accession>
    <name>A0A367LB98_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000010">
        <property type="protein sequence ID" value="RCI11699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LB98"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI11699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="164" mass="17799" checksum="CADA00CFF89E0C4D" modified="2018-11-07" version="1">MEASCYHGGGESKAKQSKAKLYNVARQPQSTGLSAQLLGNHTEHSSGYTSRVSMPIRRQEDGDTASVGGSQLIDLVCSGRTDGRTDGAGRGNGRPITAGLPAHVCNFYSFILSRSHVITLDVTLRREEEDKYKRRSFGSRSVRSGKAAEKNASRLKPTEAVEWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCJ7</accession>
    <name>A0A367LCJ7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_4596</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000008">
        <property type="protein sequence ID" value="RCI11952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCJ7"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI11952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="92" mass="10536" checksum="6ACA2283AA54B185" modified="2018-11-07" version="1">MIPIIDTKRTPLPFDASYSRRKNLQRRLTPRDASPAEGKCEELDLFGLALLVDFPSLPRRVTFWPLYESCLHGSSIQRLHNTVGKKKIDIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCN2</accession>
    <name>A0A367LCN2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCN2"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="240" mass="26024" checksum="761D43C860D0E162" modified="2018-11-07" version="1" fragment="single">ESPPERKLPVFSSSKVSIGPWELDGHEANHRDIRSETSHYGQTWQDVSGIQFPPPPQPPPTMLSLSTSHVFDHAIFLCFSTNNEGPPSHNNPHLHHRRPRRANDGDERGYSMPAPSLSQARLDSEAADPPPGPPPPPHRKPDMPPSPPVPQPPPPPPQGKPRMPSSPPHPKAPSPPPHPKAPSPPSPPHPLRKPHMPSYPSPPHPPRLSYPSPPPPPPLPLPPTLSGTDCGCNEEKPAVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCT5</accession>
    <name>A0A367LCT5_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_1063</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LCT5"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05274">
        <property type="entry name" value="KR_FAS_SDR_x"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF50">
        <property type="entry name" value="HIGHLY REDUCING POLYKETIDE SYNTHASE SRDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="10">
        <location>
            <begin position="55"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="11">
        <location>
            <begin position="974"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="2354"/>
            <end position="2432"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="974"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1131"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="8">
        <location>
            <position position="1006"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="8">
        <location>
            <position position="1197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI12248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="2438" mass="264080" checksum="4FC20E3A1F964880" modified="2018-11-07" version="1">MTQTLTLPTPEPALAQSSDDLVRSRAKAEALDLATTYINGFQKSTVPSTATAVEDNAVCIVGMACHLPGGISSPSGLWNFLHEIKSAKCLVPPDRFKIDGFYHEDGSRAGVMNVKGGYFLQEDVRHFDNSFFGINNLEASYMDPQQRKLLEVVFECFENAGLSMEDISGTNTAVYVGNFTVDYQSMQSRDPDYLHRYSATGGGTSIMSNRISHVFNLQGPSLTLDTACSSSIYALHHAVTAIKNGDCDGAIVAGANLITSPEQHLGTAQGGFLSPTSDCKPFDSSADGYARAEGVNAIYLKRFTSAVKNGERVHAVIRGTAINANGKTPGITLPNAKMQEAVVRKAYRNAGLDFADTDYIECHGTGTAVGDPIEVEGLASCFAGRHGDAVMIGSVKSNLGHSEAASGLTSVIKVALAFEHGMIPPTYGVKNLNPKLKLDVRNMRVLTEVEKWPRALRRASINSFGYGGANGHVILESVESYLDNSPSPSNGHLTNGHTTHKDQVLVLPFSAASGKSLETRRQQVGELAHQADAEELEGLANSLSRRHTKLRLRDFVLATADPKQLSLKTTGGRDEPVLGATPLPFAFVFTGQGAQYAGMARELLEKNAVFLASVRELDQVLQSLPADQAPSWTLEETILAPAATSKVNDVTRSQPLCTAVQIALVDLLRSWGVSPSAVIGHSSGEIAASYSAGLLTAPQAILAAYFRGFAVGQMKTRGAMMAAGLTNAAADDLIRDLGLTEVRVACVNAPESVTFSGNEAEVDKLQAELQKQNKFARKLETGGRAYHSRMMVQVGDLYEQLVAPYFGDSTGLGPQTATMFSTVGHSGENLCYVDSLTDMAVYFRQNLEKPVQFGSAMEALLTSSKFHLVEIGPHSALKGPIQQIRSRAKRDNVSAPYAATLIRKEDADIRLKKLAGALFSHGHDLNWNAVNSIPKCRSLPIKDLPPYPWDYSKALPWHEPRASVDIRNRKHIRHELLGTRTAAGNGIDWSWRNILRLSEMPWLRDHKLGPQAVLPGSAYVAIAIEALTQIRDLKYKLAAGEAMSFECQSINISAPFLVRDDNDAEAEHTELHTIMCQRKISTANASGDWYEFSVSSWASGHITLHCTGSIRLAQASTKANEGSVQIAGQGYEAWSMGRWYDKSREEGLNFGPHFESLTSLHTDGNRTCADAIASTHLEPPSARSAAMPYAVHPITIDACFQAAIMGGTAGNLSSLRAYVPVFIDECHIQVPKGGCASLGNEECKIHTRMERTGFSTRKVDCTLRQPNSVPVIDMKNVRMSLYTGKAPVQSENSMYLQRQPCLRILWKPDILRVHSGCADELRQYVDTFAAEQSADMKDNESLLVLGALLDLSGHKMPRMRVLELGQDCQCIAQQCLGLLGHGTAFPRCRSWSGAHVDEDGKLALEDSTSSEPYDVVVIPHHSISRKVWSQAAEHLLSVVSPQGIVMTRKTNEAVASLTLAGFITLELPRETLLAVRSHEATSLRGKQVIIVRQTPDKSSPKIDALSSALVSHFEKNIGVLKSSRISLSKIENLEFSKEVICVSLLEMEHEFLATMSEADMNRLRGITDNVAGIIWLTGANMLAAPVPDLTLSSGLSRALMLEQPALRFTILDIGVADMTKPDTAALTCNSVSSALTTSCTMDDTEFIQLGGLLYVSRFAPALDLNSLFRQRLEQDEPVKTATLAEIAPAKLSIGQVGMTDTMHFQQVAEPPTKPSAGFVDVDLRTISLNAKDVYAMNGRVETRAATTALDFGGIVSAVGPDVTHLQPGDRVVGLAPNHFGTTERVPAASVHKLLPGEEFTALATLLTVYSTALFALRDRAHLRAGESILIHGGAGAFGLAAIAMAQSMGATVYTTVGSKTKRDYLVEEMGVPAENIFNSRDASFVDGIKAATGHGVDVIINSLVGDLMHASWSSIAPFGRFVEIGKRELIDAGKLDLQVFLKNTTFTAFDLSEFFYAKDAYYRNIFYGLIAEVMTLYRAGKIKPPPVATFDVADIAQAYRYFTNKDRIGKVAISMENPQSRVPTTPAHYKTVFDAEKTYLLVGCLGGLGRSLSRWMMSRGARRFVFLGRSGCDKPTARQLVTRLQDAGASVTVVRGDVSDAKHVREAVAACVANGPIGGVVQAAMGLKEALFTTMTNDAWHIGIQPKWKGTWNLHHALEGHDKNLDFFLMTSSLSGSCGTATESNYCAANGFLDAFARWRRAKGKPAISLGLGMISEVGYLHENPEIEALLLRKGIQPLNEDEFLQVVDFGLAGPGGESDFIRQTPGVDEGAHILTGLEPYGIRKLMERGFDVNNGIMEDSRTSLLAASLLAERDTQGAGQGADAGQLTEASEWVKAVPSSAVPMIASEASAPTLRDAVLRLTKKRFGNLILMPADQVDDGSPLASFGVDSMLAAEFRTWFWNTFKLDVPFLDIVSPQKTLRNLAEFVEEKLVESWAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCW4</accession>
    <name>A0A367LCW4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Anaphase-promoting complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">L249_1330</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BCC 54312</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RING-box family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCW4"/>
    <dbReference type="STRING" id="1330021.A0A367LCW4"/>
    <dbReference type="OrthoDB" id="1681166at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16456">
        <property type="entry name" value="RING-H2_APC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000111">
        <property type="entry name" value="Anaphase-promoting complex subunit 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024991">
        <property type="entry name" value="RING-H2_APC11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12861">
        <property type="entry name" value="zf-ANAPC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="48"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RCI12255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="109" mass="12316" checksum="F6B8B585D6D97ED5" modified="2018-11-07" version="1" fragment="single">SVFSFQHDFTANAMKVTITEWNAVAIWRWDIPEDDVCGICQVHFDGTCPSCKYPGDGCSLLSGKCGHNFHMHCIIQWIKQDSARGQCPMCRQPFEWVDQANEACTSPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LCW6</accession>
    <name>A0A367LCW6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LCW6"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="400" mass="42985" checksum="250EF8AB233A9901" modified="2018-11-07" version="1" fragment="single">MPSKFRQLPMDRRALCSPRPHLVDIGHLLDKVLEPAFRPHRFALPQSHSVSPVISASRLVFYRCEEQCNVQDTNQYKTNEAVLLFAVFGIGRFFSLTGLQKSADGGLSIGYHALNLTSLEIAAVLGVLGRVILLSGLQDTEQLSGAGIVRARAEKSVDGIANAGCHVVKLTSLKATTILGGVGAGILGIRVFLSGLEKTTKKATGLLAVLRGILGGVGAGILGIRVFLSGLEKTTKEATGLLGVLRGGSFTAVFLTGLEKATGKAIRLALSAPPLRVLPTTPWTDEVAMSVRIGAAWTAAARRAQALRNFIFADEGRKRNKTDQKLMQDPIMKEDGGVISLSPKTMINDVAKKKNGDPSTDNLTTYVIVRDWGWMPRGLSRASKLRAEYIGRHPDIFPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LD32</accession>
    <name>A0A367LD32_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phytocyanin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LD32"/>
    <dbReference type="STRING" id="1330021.A0A367LD32"/>
    <dbReference type="OrthoDB" id="1921208at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052953">
        <property type="entry name" value="Ser-rich/MCO-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883:SF4">
        <property type="entry name" value="CUPREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34883">
        <property type="entry name" value="SERINE-RICH PROTEIN, PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI12142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="482" mass="46467" checksum="21FB980E1925DB59" modified="2018-11-07" version="1">MKFTTAVAATLALAPESMARLNPGSFLRRRAAQPAVLGSNNPAVLASANRQQVQSGNNNNNNLGAVARAGQVGAGQVGVGQVGVGQVGVGQVGVGQVGVGQVGINAGQGTEIIVGGGGGNQLAVGGAGSAQNVIIIWMNNGGNSPTSTINQQVTATSGGSNNNNAARAQQTQTMTLGGPEGKQFKPNKLNDLNVGDVVVMEFLGEKHSAVQSTFDKPCEKMEGGFDTGLMANPNSSMVPPPRVAMQVMTDKPVWMYCSAPMHCNMSGMTGSWNPTAEKSQEEFQRKAIESGGGGNGTAVAPAPAPAEGGGAAEGGAAEGGAAEGGAAEGGAAEGGAAEGGAVEGGAAEGGGFEGGAESGSNSEGAALTTSARFSSPTSAFNGATGNTSAEIGGATSGEAGGSASEAGTGGEGLSSSNEGPTVSASGSCPCEAACGGDATATGTGTIGPDGACSCAALCEGPALVQGMATAASPSGALRRRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LD52</accession>
    <name>A0A367LD52_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_0244</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="STRING" id="1330021.A0A367LD52"/>
    <dbReference type="OrthoDB" id="4928272at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="432"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="647"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="938"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1020"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1339"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="943"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="962"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1036"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1143"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1192"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1269"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI12162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="1371" mass="147244" checksum="D3B35CF6FCB90BA9" modified="2018-11-07" version="1" fragment="single">QPASFLTAHPRISFFSLVGPSSHRGGWVPPRQLQHPHHLLDSHREAGEKLTFLSGLLAGSPGDISAVVLIVTSFRPASSQLAFSSVSSALLIQALFIDIVLLLLLHLRHGVLARLTMTTFWNVDGLFWLLASLLSELLSSLLSSPSQLAAFFFVNPVGGSLIMGITAMIALFASTRFLLAYLFFSFRAFSLGFVGVEIWTTTGHPVFPTMFLLSLLLLQVDPRDPAPETWIDAAYMLATEIAPALPMVLIPLVATETPPMVERALSPILRSFASLVIRSVRRMFISVPAHAIRSFVNPLFVCVRCVSDQMFPMLDARMPKDKKTGDFIIAEFPDEQLPPSVTTGLRSQLQTNLPGRLQQLIRERDDSRLSPQDQRRLFQLERLVEDHTAEYERILGSAPSRTEPPRRVSPTFDQGSLIWPRALYRLPRRFDNDEGADTEQHSQCRQKDARTSRLAAIRDAAGAVPTVKVSEEPTSSTESESDGEEYQVEANDPESSQEQEGEALEMVAANDPQSSSEQQGEAEVVANDPSDIGGEAVANDPSDFGGEAETTHVQPEYYGDWVSVSSDEASDSSREHGAVEAAAPEPESPRGLEGEGVVDIADHEAQGGSLVGSLIPAATPQTLGAADCVDVPDNTPPAIEGDDLAIGEVARVSRRSERSPDRDGRNAKRQRQLPIVSSPEMTGEYSSAATPQQREVVPAAELLMEWEATGATSAAEEPHIEDPASLFQPPMDFREPMEVEEREDDEMEYSWTQEWEEMDLGGHVGQEEDGALADLTAKLQRLTLWDGEESDVAMVGVPEAVLEVVQDGHHETAPQSSEMTLDELLHAIDVEMADSFAAQQDAQLSLVNSLDDNGWDQGEFDEGQFAALLDEGLQWDTSAPNLVGSAAGPVAPQAWDSLPLDFLGKSPPLSVPEVMVVADSSTTVVPEGPEYDNAALGMGESCVAGPDGQQQPDPVPAPDNQPPMAEEVPEPAAAVQETVVADDSDDEITRALVEALTNLPDTPLLAPTAGAVQFEDSTAPQISTQPEADQPVSSYPSPPQPASPAFQPSPPRDAVSPLPIGLDGEPIVGELFTGPPPGMSDAEVAETGAGDEVVEEEKREPVINTPAEIAQRPKLLPRSRRRGRLEQQEPLAVSPALPDTAAVEDKKKSPDSKGKGKEPAAADTVDSQPGPGDCPIPIDPQLWATYAPTGEEATSSHHQQQYPAPIDMGGGLLIPGGNTKFGPAPEPASIGESSSAVPATPVTLPASQVTGSPAAGGAQSKGDADKTPRRAKALPAKKKPSLFLPKKKTAPSTPYGTRAPGSAEKERQFRSSQTLDGMDRMALDETGEASRPHARELAIAPISFVKQTRPPSEEESEEELRRSIGFFPPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDR3</accession>
    <name>A0A367LDR3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_0331</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDR3"/>
    <dbReference type="STRING" id="1330021.A0A367LDR3"/>
    <dbReference type="OrthoDB" id="5424797at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI12564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="403" mass="43856" checksum="D7FAD49B5505A0FB" modified="2018-11-07" version="1">MSTSKAAGSSSRDIRRYFSAQQQARPTPKMQKQTSSGSADDEDPLLGDSTVLRIPSLRPGVASQNSNLTMTSTSTMSAGGGNLAVVLAASPSRAGSPSSSARVVKKRLDLRRRASGRPLATTAVVKETPVPLPKIAGWNGARSGRTTTTTTAATSTTTTTTPTGLNSRGRPKGWRAGMSYSAMRGRTPPGAKSGQAQAKPALPGISKRRGRPQRLPSPPPREIYLRQRPRFVEFLCEWAGCKAELHNLETLRRHVYVVHGPRSSSCGCCCRWGDCARSVATVDEFREHTEEAHLVPIAWHLGDGPRNSRGGIHDDKRKKKKKKGDDDDDDDDDVDEDGIPAFLKDARGVQVTPSVRDQEVEDVLTWRMNRRKLKELLIRRDENLPDEDSDVAGEEEEGERGGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LDW4</accession>
    <name>A0A367LDW4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transmembrane protein 53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_0314</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus outer membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMEM53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LDW4"/>
    <dbReference type="OrthoDB" id="77878at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005640">
        <property type="term" value="C:nuclear outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008547">
        <property type="entry name" value="DUF829_TMEM53"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12265:SF30">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05705">
        <property type="entry name" value="DUF829"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI12623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="260" mass="29682" checksum="E594DDBDF6331D4E" modified="2018-11-07" version="1">MATLPTMQPLSPTVSYLDPGRLPVDGDPDLILIFSWLDARDRQIAKYLTHHRALFPASPIMLFRIPPWHMLSTWLTKRDLAPVVPMLRALINGPRCRRILVHTFSNGGLSTAVHLRQMVLAHGIKGALPTPVVLLDSCPGYFHWHRSHHTLKIVFPWWFAPLFNLAIALNFLYYALRRLPATADRHAQTLNLCNCRRTYLYGTADDIIDYRDVEDNARKAADAGFAVRMERFDGGMHVALALAHPERYWAAVRRSWKEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LE96</accession>
    <name>A0A367LE96_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_1068</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LE96"/>
    <dbReference type="STRING" id="1330021.A0A367LE96"/>
    <dbReference type="OrthoDB" id="2102561at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF3">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE SRDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI12736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="195" mass="21177" checksum="8BA74D6A049644DF" modified="2018-11-07" version="1">MSTEQKFALVTGCGKGGIGEALVKQYVRHGVHAIATVLPSEGSEHLTQAGITWFPLDVTDEKSVADLKQSILGLTGGSLDILCSLPGYTMTAIDTDVDSAKKMFNVNVFGPMQMVHYFHDMIIRATGTIVNIGSIGGIVPYMYGGERRSEKCTKIYVDTSEASYNASKAALHHWSNTLRLEMSPFRYASSEVMCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-04-02" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEG6</accession>
    <name>A0A367LEG6_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_0546</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEG6"/>
    <dbReference type="STRING" id="1330021.A0A367LEG6"/>
    <dbReference type="OrthoDB" id="5388486at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039970">
        <property type="entry name" value="TF_Grauzone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23225:SF2">
        <property type="entry name" value="AT09679P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23225">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="606"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="634"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="667"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="740"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="813"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="813"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI12810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="853" mass="93206" checksum="E4ECA8691D39F880" modified="2018-11-07" version="1" fragment="single">CLFMEPSSKKRKLAPKVNASPAANVQPAQYARETVRLDGPLCSSADSSQPACPSSNSNLSQQQQQHQQQPPPPPAQQQQQQQPFAPQDTPPSDRQDFESFARHLQDAAMLIERQSERAPYRDVSVLLLSWQDDSAVRDDVAALEQVLHKDYHYDTQRWQIPTVPNPSIKLGVQMASFLEHARPNHLLIIYYSGHGYVGSDGQLYWACNARDDAVKLKWDCVRCLFEDAQSDILLLLDTCAMPDAATAGSHGVKQAIAARSAEHHLPAADSSCSFTSNLTESLRKLAGGGPFSVQRLYDEIISQQLAQAPRVEPNGASVPPLEQSQLPIFFNLAPDKGQNLILVPLSARPLTAVNGGEDHLIDPDSVADVRFGETRTLVCTTFVGDANPDMTFFNQWLQNTPPLAAKIAVEGIFLGPPTILVISMPHSLWNVVQYDKICCFMGHITSHNMVHLYEKLVGPTGIRPSAKEMEDGRILLEARELAAVTPAHARKELDNGHDDGYRAPEPLKSPVEPKEEVEDSVEMQEAAEQLKALSHMRHRGDDAAGQRPRTSLPNAVPRDEAALDAAADPATSATASASAAAAATTAESSKSARVKAPRRFMPKQETRCNHCSHAPFKDSSSLRKHIAAAHTRPFPCAFAFAGCTSTFGSKNEWKRHIASQHLCLQYYRCSECPQGAAEGKGNEFNRKDLFTQHLRRMHAPFHVKRAMSKGDTKLLADWEESVKSMQQSCLVTRRQPPQRSACPKPGCQHEFSGAGSWDEWTEHVGRHMEKGEAQSLGVDALLARWALDEGIIEAKGDGEFRLCAGNGLVSSSSSAVKDSSSMVSAAAAAGAESSRLEDPTASLLDPKPAEHQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-06-18" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LEW4</accession>
    <name>A0A367LEW4_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S20</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_0031</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LEW4"/>
    <dbReference type="STRING" id="1330021.A0A367LEW4"/>
    <dbReference type="OrthoDB" id="10248551at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.600:FF:000004">
        <property type="entry name" value="30S ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_uS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005729">
        <property type="entry name" value="Ribosomal_uS10_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01046">
        <property type="entry name" value="uS10_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="6">
        <location>
            <begin position="20"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI12957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="116" mass="13077" checksum="B01C6E74D7B624C9" modified="2018-11-07" version="1">MSYQKPDKDHGEAPKSHKIRITLTSRKVNILEKVCAEINERAKGKELRVKGPVRLPTQCLKITTRKTPCGEGSKTWDCYEMRIHKRLIDLNAPTEVVKQIIVNIDAGVEVEVTIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LF40</accession>
    <name>A0A367LF40_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">L249_0757</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LF40"/>
    <dbReference type="STRING" id="1330021.A0A367LF40"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051704">
        <property type="entry name" value="FAD_aromatic-hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46865:SF7">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G07040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46865">
        <property type="entry name" value="OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="7"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RCI13036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="420" mass="47251" checksum="A40DB0645A0FC053" modified="2018-11-07" version="1">MPPPPLNILICGGGIAGPAAAFWLSRLGHKCTIIERHPTLRADGQQIDLREQGVTVARKMGLLPEIKSRTVDELGTSFVDSRGRSLAFFGRSGNEEQQSFTSEFEIMRGDLCKILRDAAEERVQWRFGLTVDDYRHVDDGTRVNVRFSDGTEAEYDLLIGADGQGSRVRRRMVTEDKYRPLGVFCCYFNTHRRQDDENIFSFYVAGRRRTVATRWHSPKHGQGYLMTMSHPEEFRSVLRQQDTAAQRALFSRVFAGAGWQADRLITEMNQAEDVYAFEALQVTARQWSRGRVVLLGDAAHAPSFFTGMGTSLALVGAYVLAGELAAHGDDVEAGLDAYHRRLRAFVEDSQKLGPGLPGIAFPETWWGVRIMQFIVTIMGLIRIDYLLGLLFQSLSSKSNKWQVPEYPELYAEKEEEASLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LF62</accession>
    <name>A0A367LF62_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">beta-glucosidase</fullName>
            <ecNumber evidence="13">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">L249_1082</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 13">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="13"/>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI12872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LF62"/>
    <dbReference type="STRING" id="1330021.A0A367LF62"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000002">
        <property type="entry name" value="Probable beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF5">
        <property type="entry name" value="BETA-GLUCOSIDASE M-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5016679753" description="beta-glucosidase" evidence="14">
        <location>
            <begin position="30"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="15">
        <location>
            <begin position="719"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RCI12872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="810" mass="87698" checksum="A42DB2D4CE645FA1" modified="2018-11-07" version="1">MALGDSMLIALPLTLLTLSILSSSARVEAAGPKDDGFFFGQSPPVYPSPPMTGGEEWKDAYLRARSMVDDMTLEEKISLTGGVKLGTGCSGSVTPIPRLGFPGMCLSDAGNGLRGTDLVNAYPSGIHVGASWNKALARRRGMAMAREFRKKGVNVLLGPVVGPAWRVVRGGRNWEGFSVDPYLAGSLVSETVEGIQGEGVQASVKHFIANEQEDYRSSSLFGEAVSSNIDDKTMHELYMWPFQDAVKAGCGNIMCSYNRINNSYGCANSKTLNGLLKTELGFQGFVVSDWGAQHAGVATALAGLDLAMPMGDEFWGQKLVEAVKNGSVPERRVDDMVSRLLTTWFQFKQNDSVPHPGVGMPANVVKPHLLVEGREEGALPILLEGAIEGHVLVKNSKRTLPLKRPRMLSVFGYSAKSADDWGPSHDFIQLNTWMFGLSPLDPASRLASILPTAKRSPIARMGTLIGGGGSGAVTPAVFTSPLESLKVRAARDDTALFYDLSSEKPAVDPLSEACIVLGNAWASEGYDRPSLSDNYTDGLIRTVADQCSRTIVVLHNAGVRLVDGFVHHPNVTAVVFAHLPGRDSGEALVSLLYGEASPSGKLPYTVARREADYGHVLGPDLPRGEYKNFPQSDFGEGTLLDYRRFDREGIEPRYEFGFGLSYTRFELSGLGIRKTTPTTRPLKPYPTGAVVAGGQSDLWEVLAFVEAKVRNTGDVDGAEVAQMYVGFPRGSNNNGDDSNDAVVSIRQLRGFEKTRILRPGEEQRVRFGLTRRDLSEWDVGAQRWRLVGGGYDIFVGNSSRSLPLRGNLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LFT2</accession>
    <name>A0A367LFT2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_0804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LFT2"/>
    <dbReference type="OrthoDB" id="4909005at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017001912" evidence="1">
        <location>
            <begin position="23"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="307" mass="35451" checksum="6C12A0033D59A4A4" modified="2018-11-07" version="1">MRRTSLLAVFLHLLSAGDYADAKSAAPRILKTRKITYSCGKLRHPYGLHFSILTDCLGDWRKKKRNLSRLCTPTIVAEIMVSALPSGLHDMLWTQYRLDNVSVIDEMARSLQTVDYSVSMRRALWLKRMTKKGKNVCWPDEPDFTPDDFQEFGGTLAALLVQPVTPANKTVIRRRYQTLPPGFLARNRIHYIYKAAYDYGAVWSMHEDWRHYGIIGLPSYASLQTMRDEFDTWGGRVGRLLMASMRDQYECDYHRGCVDEPRMGRAYQPWDYRALLDLWLHCVSNISPLAFTFGDVQKAPNTLWISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LG32</accession>
    <name>A0A367LG32_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">L249_0170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BCC 54312</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000007">
        <property type="protein sequence ID" value="RCI13212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LG32"/>
    <dbReference type="STRING" id="1330021.A0A367LG32"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003962">
        <property type="term" value="F:cystathionine gamma-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051750">
        <property type="entry name" value="Trans-sulfuration_enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42699:SF1">
        <property type="entry name" value="CYSTATHIONINE GAMMA-SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RCI13212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="863" mass="92534" checksum="7A4282F456563C35" modified="2018-11-07" version="1">MIHDDGQLAALGLRSELRRGFSTLSMLGLAFAVLNTWTAVAASLPVSLTSGGSISIVWGLFTAGLCNLCIAASLAEFLSAYPTAGGQYHWVAEIPNASLQGPKIMVLCVVIGTVTGAIFLIVLLFVSGDMEAVISSSAGPLLQIFLNATNNAAGAICLLMLPLICIVFALLSVMTTSSRIIFAFARDGGLPASAVFARVHPRLGQPLNALALSSAVVVLFGFVFLASSRTTTNGSAFNAIVSASVVALDLSYAMPIAVRCLRGRKALPEAPWRLPPWLGWTVDLISLAYISLTTFLFLLPPSRPVSGTTMNYCVVAFAIVVVVSVVEWVAISVSLPTWRDTLGWAHRDESVLSQFQTGYPRFFVPRLVRDLADRLVEWAKQPVAASAAVLLPSSTMARSCERYLKKKKKKKTTTTTKKNSSGSCHGHIMSFSVRFNDGLVQALDDDFHSTGPYNHVFVVLHPDSLSREARAFWQHTGFGVSSRFASFWLNSAPFLTDKTINEKEMTDAAELLPVVEARHAALSLGQRIAGLYAVSQDDVFLYHTGMSAIAHAASALRGGGDSDEAFRVAVFGGVHGFDCVLYGHASTAELEADLDSGTRFDLLVTEFPGNPLLQSSDLGRLSALSRKHGFSIIIDDTIGTAVNVDVVSSCDVICTSLTKMFSGACNVMGGSLVLSPYSGRHRSLRATVSHTYQDTYFPLDVIVMKQNSAAFESRVLMASRNAKRLVQRLRSHRSVERVYYPWGDATQRLYDRFRRPEGEYGYLVSIQFAEPAAAVAFFDALDVAKGPSLGTNFTLCCAYTLLAHVSELEWAAEHGVTEHLVRISVGIEEPDFLVALVDAALAATEPYCCGGGGGGGGGGGGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGE6</accession>
    <name>A0A367LGE6_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGE6"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="82" mass="9306" checksum="E360E41DFDB86243" modified="2018-11-07" version="1">MPCLSCSKEGGTKPLYTEIRLPRLTSLPRLFNLPYVPSFPCYSRLLCYYAVPTSITFLPIIITYSRYNVQRPRAGCSRPGVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGI8</accession>
    <name>A0A367LGI8_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGI8"/>
    <dbReference type="OrthoDB" id="4924495at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="588" mass="65944" checksum="83EBED4568D1D065" modified="2018-11-07" version="1">MTHPTTICDRKVQIGQNHVHNLSVFTQSFHPSKRLWLLTPQTLPRIRKPYTVGSQSSNPPLCYSWRKNAIYYPLRKGLVEDHPDISSLIYHPSGRPCHLFSFTCNPMQAPLIGVGVYEETLQLVTSCWTGFTVSGSLRPELLYALKRLGGEPELPWLPWMKQHARAHLQVRVSDHYCGAAVVVLLFHDLIDLDRRGELSLGGIWPTTLTQSNRSKPTLIGEKKKQACDAYGFAMICKSYEFCNFNYEYPLPLPPSSERLKHQTLTEHDGWPRSKSLDAKSPDATAAHRCRPRRQSPKSRHLRLGISKAWRLMVGQNMPLPATRARVSLAAAGLLWTELVVSRPDAWKAMHKMTGVQQESWTWSGPYCKTDVFASDSMLNGYSLFVYGLSFHVVFDFTQRIQPPSRVRGFTNIVFECVRADLKPARISLFDESRLHGTTYTCASAGSSPLSCAFALDYDYSHLGQRGGSGYYRRSDMAVVEASDQTENLDAGFSLQLLCETTVDYQTELRVYFKGVLFYVGHGRYPSFVGDAVGGAAAETPQSWHTVERTTMVMTMVTMLYVGTDQSIPDPDIRPSATAEAAILNSASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGS0</accession>
    <name>A0A367LGS0_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">L249_5464</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGS0"/>
    <dbReference type="STRING" id="1330021.A0A367LGS0"/>
    <dbReference type="OrthoDB" id="3045089at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051425">
        <property type="entry name" value="Formin_Homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054464">
        <property type="entry name" value="ULD_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725:SF1">
        <property type="entry name" value="DISHEVELLED ASSOCIATED ACTIVATOR OF MORPHOGENESIS, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725">
        <property type="entry name" value="FORMIN HOMOLOGY 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22893">
        <property type="entry name" value="ULD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="455"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RCI13610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="624" mass="69640" checksum="3C5DCE27EB1647DA" modified="2018-11-07" version="1">MPPGESSRSTSHRSEEEESSQYEAYTSYTATDEELEDDGDYEHEAVYPCDSASAINELPPSRPRSGRSATRHHRTSRQEAQYDPVQPHALNSPSVDNPEDFAGYYSQAQPFQPLPAHRGGAGYYGGRGHAHPFAHNHANHYIGGYPNGGQMVPYSYAPGQIPFSPMSNNSSGASYFGGEPRPIYDMTPYQPGFYPPQYALAAHLQQFHLTPPAPPATEAPPQPTSPPPPKEPPVDIEKIKRDAEEAAKKEHEDRLRAIDEAQKRDALIRKEAEDNMQRRLDEQRKRDEESLKAIAKAKEEADAAAVKRIEEQKKEDEERKRLQSEEMRRVEENAIRQYEANAKAEAEREKRAMEDRIRIEEAAKAQVHAILKADADAKAAAEKKAAEEADRLKLLQEEAKRKAELDALAKIEADKEAAKKAAEAEAAAKKEHEALKKRIIDEARAKFEEAAKKSDKGSINFKDAFGRKFNFPFSLVCSWQGMEELIKQAFVNVDVIGPHVQEGHYDLTGPNGEIILPSIWEKVIQPDWSISMTMWPVEKRPPLTVPPRPPMRDRGGIPIPPPPPLGMGMGPPPDWAGDRRRRTHIPNFDIIDVGPPPKSKKSAAKRNSAVLGFFAGTGKPVKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2023-02-22" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGS2</accession>
    <name>A0A367LGS2_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5553</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGS2"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI13633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="143" mass="16260" checksum="142487F5A2C8C18B" modified="2018-11-07" version="1" fragment="single">AITSPVLLTNDGSITPSRGEWLNRRDTKKTYKKKCTALSDGMSDTFILQDTALAVLRISYHAAGSSELHYRNLDDNGQITKWMFRNQSRGSGFLGNMARIRMQLLLLIAWQSLRLLPKIVKLQVKGFEKRNPPLDLVKSRSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-02-05" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGS3</accession>
    <name>A0A367LGS3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Purine nucleoside permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_5564</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGS3"/>
    <dbReference type="STRING" id="1330021.A0A367LGS3"/>
    <dbReference type="OrthoDB" id="2331083at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009486">
        <property type="entry name" value="Pur_nuclsid_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38643">
        <property type="entry name" value="PURINE NUCLEOSIDE PERMEASE C285.05-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38643:SF1">
        <property type="entry name" value="PURINE NUCLEOSIDE PERMEASE C285.05-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06516">
        <property type="entry name" value="NUP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="400" mass="43486" checksum="F4B86F45278C8D72" modified="2018-11-07" version="1">MWRRNCASGHDNFHGMRTTPFPPSKEGQRNCPSDTTNQFTPEADSWHARFHESKLGNLSAVAVASPGLSMLFPHVMCTQDGLVCQATVGEGEINAAASMTALALSPYFHLAKTYFLLAGIAGVNPREATLGSVALSRFAVQAALQYEIDPRSLPANWSTGYIPYGRSHPFEYPAILYGTEVFELNVGLRDAAAALASRASLADDDTSRHYRAMYARRDGYYAKAAQPPSVVKCDCITSDVYYSGNMLSQAFENTTRVWTNGTGVYCMTAQEDSAVLEVMVRAAVEGLVDFSRVMLMRTASDFDRPPPGVSDLHHLTRVDQNGFRIATANIYIAGIEIVKGIVADWNSTYLAGVRAPNYMGDIFGTLGGNPDFGPGSRTGGRPVRSAVSRRRSRWLAVPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2022-12-14" version="4" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LGS7</accession>
    <name>A0A367LGS7_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_5574</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000006">
        <property type="protein sequence ID" value="RCI13644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LGS7"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI13644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="64" mass="7358" checksum="738468CF8DEE2CCA" modified="2018-11-07" version="1">MQIKYDLHSIGALHWNRYAPTSPSVRRCRDSFRNGLSCLARKVSCAKNQGSWPESHNRLCARRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LH63</accession>
    <name>A0A367LH63_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">rRNA 2'-O-methyltransferase fibrillarin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Histone-glutamine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">L249_8178</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BCC 54312</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine = N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50904"/>
            <dbReference type="Rhea" id="RHEA-COMP:12837"/>
            <dbReference type="Rhea" id="RHEA-COMP:12839"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Fibrillarin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LH63"/>
    <dbReference type="STRING" id="1330021.A0A367LH63"/>
    <dbReference type="OrthoDB" id="1859733at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990259">
        <property type="term" value="F:histone H2AQ104 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008649">
        <property type="term" value="F:rRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000452">
        <property type="term" value="P:snoRNA guided rRNA 2'-O-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000056">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000001">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00351">
        <property type="entry name" value="RNA_methyltransf_FlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000692">
        <property type="entry name" value="Fibrillarin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003276">
        <property type="entry name" value="PRK04266.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335:SF17">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335">
        <property type="entry name" value="RRNA 2-O-METHYLTRANSFERASE FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01269">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006540">
        <property type="entry name" value="Nop17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00052">
        <property type="entry name" value="FIBRILLARIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01206">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RCI13727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="318" mass="33714" checksum="0D70AA1D2ECCDA93" modified="2018-11-07" version="1">MGIGFRGGPSRGGGGMRGGRGGFGGDRGGRGGRGGFRGGRGGPPRGGSRGGFSRGGARGGRGGRGGGKPGMGKGAKVIIEPHRHPGVFVVRGGKEDGLATRNLVPNESVYGEKRISHDDLVKNDDGTTTTNKVEYRMWNPFRSKLCAAIAGGADEIYMRPGSRVLYLGAASGTSVSHVADLVGPTGYVYAVEFSSRSGRDLIAMASKRTNVVPIVEDARQPTRYRMIVPMVDVIFADIAQPDQARIVGVNAHWFLKAGGGVLISIKANCIDSTAPPAEVFANEVNKMRAEQIKPKFQLTLEPFERDHCLVAGEYQRYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LH79</accession>
    <name>A0A367LH79_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">L249_7982</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BCC 54312</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat MET30/SCONB/SCON-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LH79"/>
    <dbReference type="STRING" id="1330021.A0A367LH79"/>
    <dbReference type="OrthoDB" id="190105at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="6">
        <location>
            <begin position="222"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="403"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="443"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="484"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="524"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="564"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="604"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="108"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="147"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RCI13778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="853" mass="93719" checksum="7B8C74FE826D53E5" modified="2018-11-07" version="1">MPLAATEPTKPPSIPTIVQTLFISLAHVFAARAGRSSMSALRRGSDRDPSPLPPKPRRHATTTSQASRSRLIEDCRALNAMAGYDPPLSFSQRRGSLLNEELALNTTSSVMTQRLDKMPQSRRQIRGPPTPSMPTPATDFDQQLTGSPPPPPTPAASPGPAHCQPDWSDAAADEDFFLSKVRQHFKSCSGPQRTRILADLLNLCTSPQLSFVHQFVSPLLKKDPFTSLPDELCLRILSFIDDPKVLARASQVSKRWRDLLSDDMTWKNLCVKHDYGRRLSELGPRSPLLARSTPHPLANTASEVAAANGLSGSCAPHASHSNVSRAAASAAGRPKVRSYKSHFKQRYLVEAAWRSGGKSVHRHITQEGGVVTSLHLTPKYIIVALDNAKIHVFDTDGNAPRTLQGHVMGVWAMVPWEDTMVSGGCDRDVRVWDLKTGACLHTLRGHTSTVRCLKMADANTAISGSRDTTLRIWDIRTGLCRNVLVGHQSSVRCLEIKGDIVVSGSYDTFARVWSISEGRCLQTLQGHFSQIYAIAFDGKRVVTGSLDTNVRVWDPTSGECLAILQGHTSLVGQLQMRGDTLVTGGSDGSVRVWSLEKMCPIHRLAAHDNSVTSLQFDDTRVVSGGSDGRVKIWDLKTGHLVRELIAQGEAVWRVAFEEEKCVALALRHGRTAHAAMQVWSFSPPEDKLYDHPLSLQQHVLEEDPMRPLSADEQLPDFPAAQDVDMRDAESETPGSRADWLVRNAHVREGVWRQIDGDQCRRPLLCTLGIVSFSSAPQAIDGGDVIARTMGKYCITYYGLRSTMENGGRGGSLRGRPGHWWRPGMPSGDELPFKKKKPFGTFVYSSQHCHSDSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LH90</accession>
    <name>A0A367LH90_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">L249_7980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LH90"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RCI13780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="108" mass="12318" checksum="A3CEB3A0FC2F72CC" modified="2018-11-07" version="1" fragment="single">PPQRPDDRYSDRRARSISRYSSHHSNRHSDRRAVLIAVIAPDLDSRTKVRSSEIMPNTKKITFAKLSGGDNYTYWALRIDSLLIREKLQGALGSKTYNKSEEAGLEQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHD3</accession>
    <name>A0A367LHD3_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Autophagy-related protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Autophagy-related E2-like conjugation enzyme ATG3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">L249_8237</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHD3"/>
    <dbReference type="STRING" id="1330021.A0A367LHD3"/>
    <dbReference type="OrthoDB" id="1584384at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044804">
        <property type="term" value="P:nucleophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007135">
        <property type="entry name" value="Atg3/Atg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866:SF2">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03987">
        <property type="entry name" value="Autophagy_act_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="99"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RCI13846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="342" mass="37965" checksum="ABAC63ED76C3DFA0" modified="2018-11-07" version="1">MNYIKSTVNTLRDRYTPVTHNSTFRQTGQITPEEFLAAGEYLVYKFPTWSWGDADDESRRVSYLPAGKQFLVTRNVPCHRRLDDDFAGDAGHEEALVHEGDDFRSGVGGGAASGRGDDDGWLRTGGLSSSQPLKARDVRTVDDSGNVADTTDIEDDDIPDMEEDDDDDEAIIRDVGSDSRSGRWPPHLHALHNSMMEDIVGDYKDKTVTLEDFPFFANNVKMASVHPCKHASVMKTLLDRADASLRIRRDRLRAARSASSPQSAHNNDDNNKQAVDDLADDLDKLVVQSAQDAADKDGWEEVEGVDADEQEVAIRVDQYLVVFLKFMASVTPGIEHDFTMGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHJ4</accession>
    <name>A0A367LHJ4_9HYPO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">L249_8130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BCC 54312</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHJ4"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RCI13869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000253664"/>
        </source>
    </evidence>
    <sequence length="55" mass="6586" checksum="59C517E8F6A49FD1" modified="2018-11-07" version="1" fragment="single">RNREEEEELRNSLKEEIKEELEAGEVFVLRRWENPPPFIDNFSGIKKIGDLEEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2018-11-07" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A367LHU7</accession>
    <name>A0A367LHU7_9HYPO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">L249_7927</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Ophiocordyceps polyrhachis-furcata BCC 54312</name>
        <dbReference type="NCBI Taxonomy" id="1330021"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Sordariomycetes</taxon>
            <taxon>Hypocreomycetidae</taxon>
            <taxon>Hypocreales</taxon>
            <taxon>Ophiocordycipitaceae</taxon>
            <taxon>Ophiocordyceps</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2015" name="BMC Genomics" volume="16" first="881" last="881">
            <title>Insights from the genome of Ophiocordyceps polyrhachis-furcata to pathogenicity and host specificity in insect fungi.</title>
            <authorList>
                <person name="Wichadakul D."/>
                <person name="Kobmoo N."/>
                <person name="Ingsriswang S."/>
                <person name="Tangphatsornruang S."/>
                <person name="Chantasingh D."/>
                <person name="Luangsa-ard J.J."/>
                <person name="Eurwilaichitr L."/>
            </authorList>
            <dbReference type="PubMed" id="26511477"/>
            <dbReference type="DOI" id="10.1186/s12864-015-2101-4"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BCC 54312</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="LKCN02000005">
        <property type="protein sequence ID" value="RCI13822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A367LHU7"/>
    <dbReference type="STRING" id="1330021.A0A367LHU7"/>
    <dbReference type="OrthoDB" id="9411774at2759"/>
    <dbReference type="Proteomes" id="UP000253664">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000190">
        <property type="entry name" value="C2H2 finger domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF8">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1
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